Details of the Researcher

PHOTO

Shunji Mugikura
Section
Tohoku Medical Megabank Organization
Job title
Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
20375017

Research Interests 8

  • neuropsychology

  • traumatic brain injury

  • moyamoya disease

  • MRI

  • stroke

  • functional MRI

  • amnesia

  • memory disturbance

Research Areas 1

  • Life sciences / Radiology /

Papers 205

  1. Post-brachytherapy patient management: the need for integrated health information systems in radiation safety and mortality tracking.

    Naoko Mori, Yuki Wada, Satoshi Kumagai, Yu Mori, Hiroshi Sakamoto, Shunji Mugikura

    Japanese journal of radiology　2025/04/25

    DOI： 10.1007/s11604-025-01793-7 　

  2. Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandic epilepsy surgery. International-journal

    Atsuhiko Ninomiya, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Yoshiteru Shimoda, Kazutaka Jin, Mitsugu Uematsu, Shiho Sato, Shunji Mugikura, Hiroyoshi Suzuki, Hajime Miyata, Shingo Kayano, Nobukazu Nakasato, Hidenori Endo

    Journal of neurosurgery　1-13　2025/02/14

    DOI： 10.3171/2024.10.JNS24878 　

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    OBJECTIVE: Surgery for peri-rolandic epilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. METHODS: Sixteen patients with peri-rolandic epilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data of each case, the authors examined the surgically resected area on high-resolution 3D MR images and the high-intensity area on diffusion-weighted images, which were converted to voxel data. These voxel data were superimposed on a standard brain image for neuroimaging assessment. Postoperative motor deterioration of the orofacial region, upper limb, or lower limb was noted as no, transient, or permanent deterioration and analyzed in relation to the surgically resected area and subcortical damage. Univariate analysis of the clinical factors was conducted between cases with permanent upper- and/or lower-limb motor deterioration and those with no or transient deterioration. RESULTS: The mean follow-up period was 28 months. Ten patients (62.5%) achieved Engel class I. Fourteen patients (87.5%) experienced postoperative motor deteriorations in the following areas (no/transient/permanent): orofacial (11/5/0), upper limb (9/5/2), and lower limb (9/3/4). All cases with orofacial motor deterioration underwent cortical resection of the inferior third of the peri-rolandic cortex. Cortical resection of the precentral gyrus only, in contrast to both the precentral and postcentral gyri, was not associated with permanent upper- and/or lower-limb motor deterioration. Cortical resection involving the postcentral gyrus was significantly associated with permanent upper- and/or lower-limb motor deterioration in 4 cases (25.0%). Surgically related perforating artery injury caused ischemic subcortical damage, which was significantly associated with postoperative transient or permanent motor deterioration by extending to the corticospinal tract (CST). CONCLUSIONS: Postoperative motor deterioration for peri-rolandic epilepsy was related to both the resected cortex and ischemic subcortical damage. In peri-rolandic epilepsy, cortical resection of the precentral gyrus might not necessarily cause permanent upper- and/or lower-limb motor deterioration because of the functional reserve in other peri-rolandic areas outside the epileptic focus. On the other hand, cortical resection of the postcentral gyrus could cause permanent upper- and/or lower-limb motor deterioration because of injury to the vasculature, which is crucial for the descending motor pathway in the CST.

  3. Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.

    Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto

    The Tohoku journal of experimental medicine　2025/01/16

    DOI： 10.1620/tjem.2025.J006 　

  4. The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study. International-journal

    Shigenori Kanno, Junyan Liu, Ai Kawamura, Shoko Ota, Nobuko Kawakami, Chifumi Iseki, Kazuo Kakinuma, Shiho Matsubara, Kazuto Katsuse, Kazushi Sato, Takashi Takeuchi, Yoshitaka Tanaka, Hiroyasu Kodama, Tatsuo Nagasaka, Masahiro Sai, Hayato Odagiri, Mioko Saito, Kentaro Takanami, Shunji Mugikura, Kyoko Suzuki

    Fluids and barriers of the CNS　21　(1)　108-108　2024/12/30

    DOI： 10.1186/s12987-024-00611-y 　

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    BACKGROUND: Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is one of the neuroradiological characteristics of idiopathic normal pressure hydrocephalus (iNPH), which makes statistical analyses of brain images difficult. This study aimed to develop and validate methods of accurate brain segmentation and spatial normalisation in patients with DESH by using the Computational Anatomy Toolbox (CAT12). METHODS: Two hundred ninety-eight iNPH patients with DESH and 25 healthy controls (HCs) who underwent cranial MRI were enrolled in this study. We selected the structural images of 169 patients to create customised tissue probability maps and diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) templates for patients with DESH (DESH-TPM and DESH-Template). The structural images of 38 other patients were used to evaluate the validity of the DESH-TPM and DESH-Template. DESH-TPM and DESH-Template were created using the 114 well-segmented images after the segmentation processing of CAT12. In the validation study, we compared the accuracy of brain segmentation and spatial normalisation among three conditions: customised condition, applying DESH-TPM and DESH-Template to CAT12 and patient images; standard condition, applying the default setting of CAT12 to patient images; and reference condition, applying the default setting of CAT12 to HC images. RESULTS: In the validation study, we identified three error types during segmentation. (1) The proportions of misidentifying the dura and/or extradural structures as brain structures in the customised, standard, and reference conditions were 10.5%, 44.7%, and 13.6%, respectively; (2) the failure rates of white matter hypointensity (WMH) cancellation in the customised, standard, and reference conditions were 18.4%, 44.7%, and 0%, respectively; and (3) the proportions of cerebrospinal fluid (CSF)-image deficits in the customised, standard, and reference conditions were 97.4%, 84.2%, and 28%, respectively. The spatial normalisation accuracy of grey and white matter images in the customised condition was the highest among the three conditions, especially in terms of superior convexity. CONCLUSIONS: Applying the combination of the DESH-TPM and DESH-Template to CAT12 could improve the accuracy of grey and white matter segmentation and spatial normalisation in patients with DESH. However, this combination could not improve the CSF segmentation accuracy. Another approach is needed to overcome this challenge.

  5. Recurring utterances induced by local anesthetic administration to the left frontal lobe. International-journal

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Makoto Ishida, Kazushi Ukishiro, Kazutaka Jin, Shingo Kayano, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Minoru Matsuda, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　183　15-20　2024/11/19

    DOI： 10.1016/j.cortex.2024.10.019 　

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    Recurring utterances (RUs) are a distinct language symptom observed in severe aphasia, known to be associated with global or Broca's aphasia, though their neural basis remains unclear. We present a case of RU induced by selective left frontal suppression using a novel technique named the super-selective Wada test (ssWada), which involves temporary anesthetization of specific brain regions through super-selective catheterization of cerebral arteries. This method allows for precise simulation of localized brain dysfunction. We applied this technique on a 49-year-old right-handed man with drug-resistant epilepsy as a preoperative examination. Propofol administration to the superior branch of the left middle cerebral artery (MCA), supplying the pars triangularis, pars opercularis, middle frontal gyrus, and part of the precentral gyrus, induced Broca's aphasia with RUs. The RU content was the phrase uttered at anesthesia administration. Notably, the anesthetic did not affect the temporal language area or basal ganglia. The patient showed minimal awareness of his abnormal speech despite preserved receptive language function and memory, aligning with previous observations of anosognosia in patients with RU. Contrastingly, anesthetic infusion into the inferior branch of the left MCA resulted in mixed aphasia, while right MCA infusion induced no language impairments. This case demonstrates that RUs can arise without deficits in the posterior language area or basal ganglia. It illustrates the potential of ssWada in investigating neural substrates of neuropsychological symptoms through temporary, localized brain disruption. This approach offers novel insights into brain-behavior relationships in language processing and cognition.

  6. Magnetic Resonance Imaging Texture Analysis Based on Intraosseous and Extraosseous Lesions to Predict Prognosis in Patients with Osteosarcoma

    Yu Mori, Hainan Ren, Naoko Mori, Munenori Watanuki, Shin Hitachi, Mika Watanabe, Shunji Mugikura, Kei Takase

    Diagnostics　2024/11/15

    DOI： 10.3390/diagnostics14222562 　

  7. Residual Pattern of the Hyperintense Area on T2-Weighted Magnetic Resonance Imaging After Initial Treatment Predicts the Pattern and Location of Recurrence in Patients with Newly Diagnosed Glioblastoma. International-journal

    Yoshiteru Shimoda, Masayuki Kanamori, Shota Yamashita, Ichiyo Shibahara, Rei Umezawa, Shunji Mugikura, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Hidenori Endo

    World neurosurgery　193　517-532　2024/11/12

    DOI： 10.1016/j.wneu.2024.10.012 　

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    OBJECTIVE: This study examined the clinical significance of residual hyperintense area on T2-weighted magnetic resonance imaging (T2R) without gadolinium-enhanced lesions at the end of initial treatment (debulking surgery, concomitant radiotherapy, and temozolomide) in patients with glioblastoma. METHODS: Among 150 glioblastoma cases, 77 cases without enhanced lesions at the end of initial treatment and without factors modifying the distribution of residual hyperintense area or pattern of recurrence were included. We retrospectively reviewed the relationship of residual hyperintense area after initial treatment with progression-free survival (PFS), overall survival (OS), and pattern of recurrence. RESULTS: In these 77 cases, the median PFS and OS were 12.4 and 27.4 months, respectively. At the end of initial treatment, 55 (71.4%) cases had residual hyperintense area (T2 residual group, T2R), whereas 22 (28.6%) showed no hyperintense area (T2 disappeared group, disappeared hyperintense area on T2-weighted magnetic resonance imaging [T2D]). Based on univariate and multivariate analyses, the residual hyperintense area after initial treatment was not a prognostic factor for PFS or OS. Distant recurrences occurred more frequently in the T2D group than in the T2R group 50.0% versus 9.5%. In the T2R group, the recurrence site coincided with the residual hyperintense area in 36 (85.7%) of 42 recurrences. CONCLUSIONS: The T2R at the end of initial treatment can predict local recurrence. However, the distant recurrence occurred frequently in T2D group. Thus, attention should be paid to local recurrences in T2R group and distant recurrences in T2D group.

  8. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの最終報告2024

    田代 学, Wu Yingying, 平岡 宏太良, 冨田 尚希, 小林 良太, Tekea Berihu, 原田 龍一, 菊地 飛鳥, 武田 和子, 草場 美津江, 菊池 昭夫, 古川 勝敏, 渡部 浩司, 麦倉 俊司, 川勝 忍, 石井 賢二, 二橋 尚志, 加藤 隆司, 古本 祥三, 岡村 信行

    Dementia Japan　38　(4)　677-677　2024/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  9. Clinical significance of cerebral microbleeds in patients with germinoma who underwent long-term follow-up. International-journal

    Masayuki Kanamori, Shunji Mugikura, Osamu Iizuka, Naoko Mori, Yoshiteru Shimoda, Ichiyo Shibahara, Rei Umezawa, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Kyoko Suzuki, Hidenori Endo

    Journal of neuro-oncology　170　(1)　173-184　2024/10

    DOI： 10.1007/s11060-024-04753-9 　

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    PURPOSE: This study identified the factors affecting cerebral microbleed (CMBs) development. Moreover, their effects on intelligence and memory and association with stroke in patients with germinoma who had long-term follow-up were evaluated. METHODS: This study included 64 patients with germinoma who were histologically and clinically diagnosed with and treated for germinoma. These patients were evaluated cross-sectionally, with a focus on CMBs on susceptibility-weighted magnetic resonance imaging (SWI), brain atrophy assessed through volumetric analysis, and intelligence and memory. RESULTS: The follow-up period was from 32 to 412 (median: 175.5) months. In total, 43 (67%) patients had 509 CMBs and 21 did not have CMBs. Moderate correlations were observed between the number of CMBs and time from initial treatments and recurrence was found to be a risk factor for CMB development. Increased temporal CMBs had a marginal effect on the processing speed and visual memory, whereas brain atrophy had a statistically significant effect on verbal, visual, and general memory and a marginal effect on processing speed. Before SWI acquisition and during the follow-up periods, eight strokes occurred in four patients. All of these patients had ≥ 15 CMBs on SWI before stroke onset. Meanwhile, 33 patients with < 14 CMBs or 21 patients without CMBs did not experience stroke. CONCLUSION: Patients with a longer time from treatment initiation had a higher number of CMBs, and recurrence was a significant risk factor for CMB development. Furthermore, brain atrophy had a stronger effect on memory than CMBs. Increased CMBs predict the stroke onset.

  10. Blake's pouch cyst-like imaging abnormalities in idiopathic normal pressure hydrocephalus

    Yumiko Saito, Toru Baba, Wataru Narita, Shigenori Kanno, Shunji Mugikura, Yasuko Tatewaki, Yoshiyuki Nishio, Osamu Iizuka, Yasuyuki Taki, Teiji Tominaga, Etsuro Mori, Kyoko Suzuki

    Brain Disorders　15　100153-100153　2024/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.dscb.2024.100153 　

    ISSN： 2666-4593

  11. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N. Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Scientific Reports　14　(1)　2024/08/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-69726-4 　

    eISSN： 2045-2322

  12. “Caterpillar sign” in corpus callosum associated with curvilinear pericallosal lipoma in MRI: A case report

    Kazutoshi Konomatsu, Yosuke Kakisaka, Shiho Sato, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Kazutaka Jin, Shunji Mugikura, Masashi Aoki, Nobukazu Nakasato

    Radiology Case Reports　19　(5)　2058-2061　2024/05

    DOI： 10.1016/j.radcr.2024.02.058 　

    eISSN： 1930-0433

  13. Prospects of perfusion contrast-enhanced ultrasound (CE-US) in diagnosing axillary lymph node metastases in breast cancer: a comparison with lymphatic CE-US

    Mori, N., Li, L., Matsuda, M., Mori, Y., Mugikura, S.

    Journal of Medical Ultrasonics　2024/04/20

    DOI： 10.1007/s10396-024-01444-w 　

    ISSN： 1613-2254 1346-4523

  14. The grasp reflex in patients with idiopathic normal pressure hydrocephalus. International-journal

    Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

    Journal of neurology　2024/04/08

    DOI： 10.1007/s00415-024-12341-0 　

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    OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.

  15. Cerebral venous sinus thrombosis detected using diffusion-weighted magnetic resonance imaging during maintenance temozolomide chemotherapy in a patient with glioblastoma: illustrative case. International-journal

    Youhei Takeuchi, Ryuta Saito, Masayuki Kanamori, Kuniyasu Niizuma, Shunji Mugikura, Hidenori Endo

    Journal of neurosurgery. Case lessons　7　(9)　2024/02/26

    DOI： 10.3171/CASE23762 　

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    BACKGROUND: Cerebral venous sinus thrombosis (CVST) sometimes occurs in the background of hypercoagulopathic disorders, including malignancy, chemotherapy, etc. Glioblastoma (GBM) is a malignancy found in the central nervous system, and reports on cases of GBM complicated by CVST are sparse. The authors herein report a case of GBM complicated by CVST during maintenance temozolomide (TMZ) chemotherapy and describe the utility of diffusion-weighted magnetic resonance imaging (MRI) for the detection of CVST. OBSERVATIONS: A 65-year-old male was treated for left temporal GBM. After surgical removal of the lesion, the patient was treated with chemoradiation therapy, which included 60 Gy local radiation with concomitant TMZ chemotherapy. He was subsequently received TMZ maintenance therapy. Routine MRI performed 7 months after surgery revealed no evidence of tumor recurrence. However, diffusion-weighted imaging (DWI) revealed a high-intensity signal at the posterior portion of the superior sagittal sinus, indicating the presence of a thrombus. In addition to the preexisting symptoms, the patient experienced some disorientation. Angiography revealed an obstruction in the superior sagittal sinus, right transverse sinus, right sigmoid sinus, and straight sinus. His symptoms improved with endovascular and anticoagulant therapy. LESSONS: Performing DWI during routine follow-up can help in the early diagnosis of CVST in patients with malignant gliomas.

  16. 当院で経験したlymphomatosis cerebriの画像所見に関する検討

    阿部 未玲, 森下 陽平, 遠藤 成, 山森 瑛子, 加藤 恵里奈, 李 麗, 佐藤 志帆, 梅津 篤司, 麦倉 俊司, 高瀬 圭

    Japanese Journal of Radiology　42　(Suppl.)　9-9　2024/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  17. Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis

    Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

    Journal of Clinical Imaging Science　13　38-38　2023/12/22

    Publisher: Scientific Scholar

    DOI： 10.25259/jcis_77_2023 　

    ISSN： 2156-7514

    eISSN： 2156-5597

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    Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.

  18. Exploring the Variations in Angles Around Basilar Bifurcation Categorized by Aneurysm Locations

    Fangjia Pan, Philippe Bijlenga, Naoko Mori, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    2023 15th Biomedical Engineering International Conference (BMEiCON)　2023/10/28

    Publisher: IEEE

    DOI： 10.1109/bmeicon60347.2023.10322063 　

  19. Simulation of the occipital transtentorial approach incorporating visualization of the cerebellar tentorium using three-dimensional computed tomography angiography and gadolinium-enhanced T1-weighted magnetic resonance imaging: technical note. International-journal

    Yuto Shingai, Masayuki Kanamori, Yoshiteru Shimoda, Shingo Kayano, Hitoshi Nemoto, Shunji Mugikura, Ryuta Saito, Teiji Tominaga

    Neurosurgical review　46　(1)　259-259　2023/09/29

    DOI： 10.1007/s10143-023-02170-6 　

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    The occipital transtentorial approach (OTA) is one of the useful approaches to the lesions of the pineal region, dorsal brainstem, and supracerebellar region. However, a wide operative field is sometimes difficult to obtain due to the tentorial sinus and bridging veins. This study evaluated the usefulness of preoperative simulation of OTA, specifically including the cerebellar tentorium in 9 patients. All patients underwent computed tomography angiography and venography and gadolinium-enhanced three-dimensional T1-weighted magnetic resonance images (Gd-3D-T1WI). The images were fused, and the cerebellar tentorium, vessels, and tumor were manually extracted from Gd-3D-T1WI to obtain the simulation images. Visualization of the cerebellar tentorium could discriminate between bridging veins from the occipital lobe and cerebellum, and recognize the site of bridging to the tentorial sinus and variants which may interfere with the tentorial incision. Simulation of the tentorial incision was also possible based on the relationships between the tumor, tentorial sinus, bridging vein, and cerebellar tentorium. The simulation suggested that safe tentorial incision was difficult in two sides because of the crossed tentorial sinus draining the left basal vein and draining veins from the glioblastoma. The OTA was performed in eight cases, and no difficulty was experienced in the tentorial incision in all cases. The simulation findings of the bridging vein and tentorial sinus were consistent with the intraoperative findings. Preoperative simulation including the cerebellar tentorium is useful for determining the optimum and safe side and required extent of the tentorial incision necessary for tumor resection with the OTA.

  20. Visualization of the lenticulostriate arteries, long insular arteries, and long medullary arteries on intra-arterial computed tomography angiography with ultrahigh resolution in patients with glioma. International-journal

    Yoshinari Osada, Masayuki Kanamori, Shin-Ichiro Osawa, Shingo Kayano, Hiroki Uchida, Yoshiteru Shimoda, Shunji Mugikura, Teiji Tominaga, Hidenori Endo

    Acta neurochirurgica　2023/09/20

    DOI： 10.1007/s00701-023-05794-1 　

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    PURPOSE: The anatomical association between the lesion and the perforating arteries supplying the pyramidal tract in insulo-opercular glioma resection should be evaluated. This study reported a novel method combining the intra-arterial administration of contrast medium and ultrahigh-resolution computed tomography angiography (UHR-IA-CTA) for visualizing the lenticulostriate arteries (LSAs), long insular arteries (LIAs), and long medullary arteries (LMAs) that supply the pyramidal tract in two patients with insulo-opercular glioma. METHODS: This method was performed by introducing a catheter to the cervical segment of the internal carotid artery. The infusion rate was set at 3 mL/s for 3 s, and the delay time from injection to scanning was determined based on the time-to-peak on angiography. On 2- and 20-mm-thick UHR-IA-CTA slab images and fusion with magnetic resonance images, the anatomical associations between the perforating arteries and the tumor and pyramidal tract were evaluated. RESULTS: This novel method clearly showed the relationship between the perforators that supply the pyramidal tract and tumor. It showed that LIAs and LMAs were far from the lesion but that the proximal LSAs were involved in both cases. Based on these results, subtotal resection was achieved without complications caused by injury of perforators. CONCLUSION: UHR-IA-CTA can be used to visualize the LSAs, LIAs, and LMAs clearly and provide useful preoperative information for insulo-opercular glioma resection.

  21. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. International-journal

    Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

    Journal of Alzheimer's disease : JAD　2023/09/11

    DOI： 10.3233/JAD-230318 　

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    BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.

  22. 片側扁桃体腫大を伴う側頭葉てんかん患者における発作時脳波の特徴

    此松 和俊, 神 一敬, 板橋 泉, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 麦倉 俊司, 青木 正志, 中里 信和

    てんかん研究　41　(2)　451-451　2023/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  23. Role of Magnetic Resonance Imaging in the Screening of Closed Spinal Dysraphism. Peer-reviewed

    Hidekazu Aoki, Shunji Mugikura, Reizo Shirane, Toshiaki Hayashi, Tomomi Kimiwada, Kiyohide Sakai, Keiko Ainoya, Hideki Ota, Kei Takase, Yoshihisa Shimanuki

    Neurologia medico-chirurgica　2023/08/30

    DOI： 10.2176/jns-nmc.2023-0002 　

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    Closed spinal dysraphism (CSD) encompasses a heterogeneous group of spinal cord deformities, which can be accompanied by several types of skin stigmata. These skin stigmata may include inconspicuous features, such as sacral dimples and deformed gluteal clefts, but the association between such mild skin stigmata and CSD is uncertain. This study aimed to reevaluate the indication for magnetic resonance imaging (MRI) in patients with skin stigmata while considering the indication for surgery. A retrospective analysis was conducted on magnetic resonance images of 1255 asymptomatic children with skin stigmata between 2003 and 2015. Skin stigmata classification was based on medical chart data. All subtypes of CSDs except for filum terminale lipomas (FTL), FTL thicker than 2 mm or with low conus medullaris, were considered to meet the surgical indication. CSD prevalence was estimated while considering the surgical indications and assessed after excluding all FTL cases. Skin stigmata were classified into seven types, dimple, deformed gluteal cleft, hair, subcutaneous mass, appendage, discoloration, and protruding bone, and included 1056 isolated and 199 complex ones. The prevalence of CSD was 19.5%, 6.8%, and 0.5% among patients with isolated dimples (n = 881) and 13.9%, 5.8%, and 0.7% among those with isolated deformed gluteal clefts (n = 136) for all cases, surgical indications, and patients without FTL, respectively. Dimples and deformed gluteal clefts had a low prevalence of CSD requiring surgical intervention, and cases without FTL were rare. Asymptomatic patients with mild skin stigmata may not require immediate MRI.

  24. Generalized versus Specific Boundary Conditions for CFD in vertebral-basilar artery

    Fangjia Pan, Naoko Mori, Shunji Mugikura, Philippe Bijlenga, Makoto Ohta, Hitomi Anzai

    2023 8th International Conference on Instrumentation, Control, and Automation (ICA)　2023/08/09

    Publisher: IEEE

    DOI： 10.1109/ica58538.2023.10273076 　

  25. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Peer-reviewed

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N. Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

    JMA Journal　6　(3)　246-264　2023/07

    Publisher: Japan Medical Association

    DOI： 10.31662/jmaj.2022-0220 　

    ISSN： 2433-328X

    eISSN： 2433-3298

  26. Letter to the Editor on "Pseudo-Enhancement in Intracranial Aneurysms on Black-Blood MRI: Effects of Flow Rate, Spatial Resolution, and Additional Flow Suppression". International-journal

    Naoko Mori, Hidenori Endo, Shunji Mugikura

    Journal of magnetic resonance imaging : JMRI　57　(3)　964-964　2023/03

    DOI： 10.1002/jmri.28293 　

  27. Principal component analysis of texture features for grading of meningioma: not effective from the peritumoral area but effective from the tumor area. International-journal

    Naoko Mori, Shunji Mugikura, Toshiki Endo, Hidenori Endo, Yo Oguma, Li Li, Akira Ito, Mika Watanabe, Masayuki Kanamori, Teiji Tominaga, Kei Takase

    Neuroradiology　65　(2)　257-274　2023/02

    DOI： 10.1007/s00234-022-03045-1 　

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    PURPOSE: To investigate whether texture features from tumor and peritumoral areas based on sequence combinations can differentiate between low- and non-low-grade meningiomas. METHODS: Consecutive patients diagnosed with meningioma by surgery (77 low-grade and 28 non-low-grade meningiomas) underwent preoperative magnetic resonance imaging including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast-enhanced T1WI (CE-T1WI). Manual segmentation of the tumor area was performed to extract texture features. Segmentation of the peritumoral area was performed for peritumoral high-signal intensity (PHSI) on T2WI. Principal component analysis was performed to fuse the texture features to principal components (PCs), and PCs of each sequence of the tumor and peritumoral areas were compared between low- and non-low-grade meningiomas. Only PCs with statistical significance were used for the model construction using a support vector machine algorithm. k-fold cross-validation with receiver operating characteristic curve analysis was used to evaluate diagnostic performance. RESULTS: Two, one, and three PCs of T1WI, apparent diffusion coefficient (ADC), and CE-T1WI, respectively, for the tumor area, were significantly different between low- and non-low-grade meningiomas, while PCs of T2WI for the tumor area and PCs for the peritumoral area were not. No significant differences were observed in PHSI. Among models of sequence combination, the model with PCs of ADC and CE-T1WI for the tumor area showed the highest area under the curve (0.84). CONCLUSION: The model with PCs of ADC and CE-T1WI for the tumor area showed the highest diagnostic performance for differentiating between low- and non-low-grade meningiomas. Neither PHSI nor PCs in the peritumoral area showed added value.

  28. Salvage craniospinal irradiation for recurrent intracranial germinoma: a single institution analysis Peer-reviewed

    Masayuki Kanamori, Yoshiteru Shimoda, Rei Umezawa, Osamu Iizuka, Shunji Mugikura, Kyoko Suzuki, Hisanori Ariga, Keiichi Jingu, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

    Journal of Radiation Research　64　(2)　428-437　2023/01/05

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/jrr/rrac095 　

    ISSN： 0449-3060

    eISSN： 1349-9157

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    Abstract This study investigated the effectiveness and safety of low-dose salvage craniospinal irradiation (CSI) for recurrent germinoma. We retrospectively reviewed long-term tumor control and late adverse effects in 15 recurrent germinoma patients treated at our hospital between 1983 and 2019. Following the first recurrence of germinoma, seven were treated with 24–30 Gy of salvage CSI, three underwent non-CSI, and five were treated with only chemotherapy. CSI achieved a significantly better recurrence-free survival rate after the first recurrence compared to other strategies (100% vs 33%, p &amp;lt; 0.001: log-rank test). To evaluate the safety of salvage CSI, we assessed the outcomes at the final follow-up of seven patients who received salvage CSI at first recurrence and three patients who received salvage CSI at second recurrence. The median follow-up period was 220 months after initial treatment. Five patients who received 40–50 Gy of radiation therapy or underwent multiple radiation therapy before salvage CSI were classified into Group A, whereas five patients treated with platinum-based chemotherapy and 24–32 Gy of radiation therapy to the primary site, whole ventricle, or whole brain were classified into Group B. In Group A, one had endocrine dysfunction and the other had visual dysfunction. None were socially independent. Meanwhile, in Group B, no endocrine or visual dysfunction was found, and three patients were socially independent. Salvage CSI achieved excellent tumor control in recurrent germinoma and was safe in patients initially treated with low-dose radiation therapy and chemotherapy.

  29. 扁桃体肥大を伴う側頭葉てんかん患者における発作間欠期の神経磁場スパイクのECD配向(ECD direction of interictal neuromagnetic spikes in patients with temporal lobe epilepsy with amygdala enlargement)

    Konomatsu Kazutoshi, Jin Kazutaka, Ishida Makoto, Sato Shiho, Morishita Yohei, Soga Temma, Ukishiro Kazushi, Kakisaka Yosuke, Kanno Akitake, Mugikura Shunji, Aoki Masashi, Nakasato Nobukazu

    日本生体磁気学会誌　36　(1)　158-159　2023

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  30. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告2022

    田代 学, 平岡 宏太良, 冨田 尚希, 石木 愛子, 小林 良太, 四月朔日 聖一, メスフィン・ベリフ, 武田 和子, 草場 美津江, 菊池 昭夫, 渡部 浩司, 麦倉 俊司, 古川 勝敏, 加藤 隆司, 石井 賢二, 川勝 忍, 原田 龍一, 古本 祥三, 岡村 信行

    老年精神医学雑誌　33　(増刊II)　341-341　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  31. Letter to the editor on “Second‑opinion reads in prostate MRI: added value of subspecialty interpretation and review at multidisciplinary rounds” Peer-reviewed

    Naoko Mori, Shunji Mugikura, Kei Takase

    Abdominal Radiology　47　(11)　3958-3960　2022/11

    DOI： 10.1007/s00261-022-03653-8 　

    ISSN： 2366-004X

    eISSN： 2366-0058

  32. 脳構造MRI画像を用いた神経疾患の年齢予測の検証

    松島 斗真, 吉永 健二, 高村 恒人, 舞草 伯秀, 麦倉 俊司, 森 菜緒子, 布施 昇男, 関口 敦, 阿部 十也, 花川 隆

    臨床神経生理学　50　(5)　417-417　2022/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  33. Usefulness of maximum intensity projection images of non-enhanced CT for detection of hyperdense middle cerebral artery sign in acute thromboembolic ischemic stroke Peer-reviewed

    Sota Oguro, Shunji Mugikura, Hideki Ota, Seiji Bito, Yuta Asami, Wataru Sotome, Yoshiaki Ito, Hideki Kaneko, Kazuyo Suzuki, Nobuya Higuchi, Kei Takase

    Japanese Journal of Radiology　40　(10)　1046-1052　2022/10

    DOI： 10.1007/s11604-022-01289-8 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  34. Letter to the editor on “The MRI estimations of placental thickness and cervical length correlate with postpartum hemorrhage (PPH) in patients with risk for placenta accreta spectrum (PAS) disorders” Peer-reviewed

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Placenta　128　72　2022/10

    DOI： 10.1016/j.placenta.2022.08.008 　

    ISSN： 0143-4004

    eISSN： 1532-3102

  35. Diffusion kurtosis imaging: An effective method to evaluate the grade of glioma based on the assessment of histological nuclear size and entropy Peer-reviewed

    Naoko Mori, Shunji Mugikura, Kei Takase

    Clinical Neurology and Neurosurgery　221　2022/10

    DOI： 10.1016/j.clineuro.2022.107415 　

    ISSN： 0303-8467

    eISSN： 1872-6968

  36. Letter to the editor to the article, ‘Severe unilateral proprioceptive loss in medullary- rostral spinal cord infarction. A posterior spinal artery syndrome’ by Caplan LR and Chang YM Peer-reviewed

    Shunji Mugikura, Naoko Mori

    Journal of Stroke and Cerebrovascular Diseases　31　(9)　2022/09

    DOI： 10.1016/j.jstrokecerebrovasdis.2022.106620 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  37. Multimodal imaging findings including high-resolution 3D T2-weighted imaging for COVID-19 vaccine-associated axillary lymphadenopathy in a patient with breast cancer

    Hiroaki Shimizu, Naoko Mori, Hainan Ren, Minoru Miyashita, Satoko Sato, Shunji Mugikura, Kei Takase

    Radiology Case Reports　17　(8)　2831-2836　2022/08

    DOI： 10.1016/j.radcr.2022.04.044 　

    eISSN： 1930-0433

  38. Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging Peer-reviewed

    Naoko Mori, Chihiro Inoue, Hajime Tamura, Tatsuo Nagasaka, Hainan Ren, Satoko Sato, Yu Mori, Minoru Miyashita, Shunji Mugikura, Kei Takase

    Magnetic Resonance Imaging　90　53-60　2022/07

    DOI： 10.1016/j.mri.2022.04.003 　

    ISSN： 0730-725X

    eISSN： 1873-5894

  39. The role of magnetic resonance imaging in prostate cancer patients on active surveillance Peer-reviewed

    Naoko Mori, Shunji Mugikura, Kei Takase

    The British Journal of Radiology　96　(1151)　20220140　2022/05/23

    DOI： 10.1259/bjr.20220140 　

    eISSN： 1748-880X

  40. The Role of the Ventromedial Prefrontal Cortex in Preferential Decisions for Own- and Other-Age Faces Peer-reviewed

    Ayahito Ito, Kazuki Yoshida, Ryuta Aoki, Toshikatsu Fujii, Iori Kawasaki, Akiko Hayashi, Aya Ueno, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    Frontiers in Psychology　13　2022/03/11

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyg.2022.822234 　

    eISSN： 1664-1078

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    Own-age bias is a well-known bias reflecting the effects of age, and its role has been demonstrated, particularly, in face recognition. However, it remains unclear whether an own-age bias exists in facial impression formation. In the present study, we used three datasets from two published and one unpublished functional magnetic resonance imaging (fMRI) study that employed the same pleasantness rating task with fMRI scanning and preferential choice task after the fMRI to investigate whether healthy young and older participants showed own-age effects in face preference. Specifically, we employed a drift-diffusion model to elaborate the existence of own-age bias in the processes of preferential choice. The behavioral results showed higher rating scores and higher drift rate for young faces than for older faces, regardless of the ages of participants. We identified a young-age effect, but not an own-age effect. Neuroimaging results from aggregation analysis of the three datasets suggest a possibility that the ventromedial prefrontal cortex (vmPFC) was associated with evidence accumulation of own-age faces; however, no clear evidence was provided. Importantly, we found no age-related decline in the responsiveness of the vmPFC to subjective pleasantness of faces, and both young and older participants showed a contribution of the vmPFC to the parametric representation of the subjective value of face and functional coupling between the vmPFC and ventral visual area, which reflects face preference. These results suggest that the preferential choice of face is less susceptible to the own-age bias across the lifespan of individuals.

  41. Perforators of the posterior communicating artery and memory disturbance. International-journal

    Shunji Mugikura, Naoko Mori

    Acta neurochirurgica　2022/02/27

    DOI： 10.1007/s00701-022-05147-4 　

  42. Grading of placental accrete spectrum using texture analysis of magnetic resonance imaging. International-journal

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Clinical imaging　85　8-9　2022/02/22

    DOI： 10.1016/j.clinimag.2022.02.018 　

  43. Differences in the identification rate of inferior sagittal sinus among imaging modalities.

    Naoko Mori, Shunji Mugikura

    Japanese journal of radiology　2022/02/16

    DOI： 10.1007/s11604-022-01251-8 　

  44. 未破裂動脈瘤の造影MRI vessel wall imaging stableとunstableの分別に有用な定量的パラメータの分析

    森 菜緒子, 麦倉 俊司, 高瀬 圭, 遠藤 英徳

    Japanese Journal of Radiology　40　(Suppl.)　2-2　2022/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  45. 関節リウマチ薬物治療効果判定に有効な手関節ダイナミックMRIのパラメータ検証

    森 菜緒子, 常陸 真, 麦倉 俊司, 高瀬 圭, 森 優, 井上 麻美

    Japanese Journal of Radiology　40　(Suppl.)　5-5　2022/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  46. Vascular supply of the column of fornix. International-journal

    Shunji Mugikura, Naoko Mori, Shoki Takahashi

    Surgical and radiologic anatomy : SRA　44　(2)　307-308　2022/02

    DOI： 10.1007/s00276-021-02846-y 　

  47. Letter to the editor on "High signal intensity on diffusion-weighted magnetic resonance images is a useful finding for detecting early-stage pancreatic cancer". International-journal Peer-reviewed

    Hainan Ren, Naoko Mori, Shunji Mugikura, Kei Takase

    Abdominal radiology (New York)　47　(2)　905-906　2022/02

    DOI： 10.1007/s00261-021-03346-8 　

  48. Extra- or Peritumoral Hyperintensity on T2-weighted Images in Patients with Breast Cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    Radiology　302　(2)　E7-E8　2022/02

    DOI： 10.1148/radiol.2021210939 　

  49. Longitudinal evaluation of apparent diffusion coefficient values as a predictor of Prostate Cancer Research International Active Surveillance reclassification. International-journal Peer-reviewed

    Eri Ota, Naoko Mori, Shinichi Yamashita, Shunji Mugikura, Akihiro Ito, Kei Takase

    Abdominal radiology (New York)　47　(2)　814-826　2022/02

    DOI： 10.1007/s00261-021-03372-6 　

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    PURPOSE: This study aimed to evaluate the effectiveness of apparent diffusion coefficient (ADC) parameters in distinguishing between Prostate Cancer Research International Active Surveillance (PRIAS) non-reclassification and reclassification groups during active surveillance (AS) of prostate cancer. METHODS: We included 55 patients who fulfilled the PRIAS criteria and underwent ≥ 2 magnetic resonance imaging (MRI) including diffusion-weighted imaging with an interval of ≤ 3 years between baseline and second MRI. A mono-exponential fitting model was used to automatically create ADC maps with minimum b-values of 0 and maximum of 2000 s/mm2. For detectable lesions on ADC maps, the lesions were manually segmented on each slice of the ADC maps. For undetectable lesions, the corresponding normal-appearing zone of the lobe on each slice of ADC maps was segmented. The ADC data for each slice were summed to obtain the 25th, 50th, and 75th percentile ADC values of the histogram at baseline and second MRI. These ADC parameters at baseline and second MRI, and the changes of ADC parameters from baseline to second MRI were compared between PRIAS non-reclassification and reclassification groups. RESULTS: The PRIAS reclassification group had significantly lower 25th, 50th, and 75th percentile ADC values at second MRI compared to the non-reclassification group. The non-reclassification group had significantly lower changes in ADC values in these percentiles compared to the reclassification group. CONCLUSION: The ADC parameters at second MRI and the changes from baseline to second MRI may be effective distinguishing factors between PRIAS non-reclassification and reclassification groups.

  50. Application of cumulative summation (CUSUM) method and mathematical model to evaluate the learning effect in central venous catheter port implantation. Peer-reviewed

    Naoko Mori, Hiroaki Shimizu, Shunji Mugikura, Kei Takase

    Japanese journal of radiology　2022/01/22

    DOI： 10.1007/s11604-021-01242-1 　

  51. Quantitative assessment of microstructural evolution of intracranial aneurysm wall by vessel wall imaging. International-journal Peer-reviewed

    Hidenori Endo, Naoko Mori, Shunji Mugikura, Kuniyasu Niizuma, Shunsuke Omodaka, Kei Takase, Teiji Tominaga

    Neuroradiology　64　(7)　1343-1350　2022/01/08

    DOI： 10.1007/s00234-021-02877-7 　

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    PURPOSE: This study aimed to evaluate new quantitative parameters of aneurysm wall enhancement (AWE) on magnetic resonance vessel wall imaging (VWI) in differentiating between the stable and evolving unruptured intracranial aneurysms (UIAs). METHODS: Thirty-eight consecutive patients with UIAs (27 stable and 11 evolving) underwent VWI with contrast-enhanced 3D T1 volume isotropic turbo spin echo acquisition. The voxel-based enhancement maps were created using pre- and post-contrast images. The aneurysmal lumen with signal suppression by black-blood method was segmented. Then, one voxel outer and inner layers of the lumen contour were automatically segmented. The shape features of the aneurysms and AWE of the two layers were compared between stable and evolving groups. RESULTS: The shape features, including aneurysm volume, surface, and compacity were significantly different between the stable and evolving groups (P = 0.024, 0.028, and 0.033, respectively). Stable and evolving groups also differed significantly in the AWE at the union of outer and inner layers of the aneurysm wall (P = 0.0082) but not in that of the outer or inner layer alone. Multivariate logistic regression analysis revealed significant differences in aneurysm volume, surface, and AWE at the union of outer and inner layers between the two groups (P = 0.0029, 0.0092, and 0.0033, respectively). Receiver operating characteristics curve analysis revealed that the area under the curve of the logistic regression model was 0.89. CONCLUSION: Quantitative combined analysis of aneurysm shape features and AWE of the union of outer and inner layers were effective for differentiating between stable and evolving UIAs.

  52. American College of Rheumatology and the European League Against Rheumatism classification criteria for IgG4-related disease: an update for radiologists Peer-reviewed

    Hainan Ren, Naoko Mori, Satoko Sato, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Japanese Journal of Radiology　40　(9)　876-893　2022

    DOI： 10.1007/s11604-022-01282-1 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  53. Vascular supplies to the column of the fornix other than the subcallosal artery: median artery of the corpus callosum and posterior choroidal arteries. International-journal Peer-reviewed

    Shunji Mugikura, Naoko Mori, Shoki Takahashi

    Acta neurochirurgica　164　(1)　167-168　2022/01

    DOI： 10.1007/s00701-021-05063-z 　

  54. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation　8　(1)　44-44　2021/12/10

    DOI： 10.1038/s41439-021-00175-5 　

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    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  55. Prediction of placenta accreta spectrum using texture analysis on coronal and sagittal T2-weighted imaging. International-journal

    Hainan Ren, Naoko Mori, Shunji Mugikura, Hiroaki Shimizu, Sakiko Kageyama, Masatoshi Saito, Kei Takase

    Abdominal radiology (New York)　46　(11)　5344-5352　2021/11

    DOI： 10.1007/s00261-021-03226-1 　

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    PURPOSE: To separately perform visual and texture analyses of the axial, coronal, and sagittal planes of T2-weighted images and identify the optimal method for differentiating between the normal placenta and placenta accreta spectrum (PAS). METHODS: Eighty consecutive patients (normal group, n = 50; PAS group, n = 30) underwent preoperative MRI. A scoring system (0-2) was used to evaluate the degree of abnormality observed in visual analysis (bulging, abnormal vascularity, T2 dark band, placental heterogeneity). The axial, coronal, and sagittal planes were manually segmented separately to obtain texture features, and seven combinations were obtained: axial; coronal; sagittal; axial and coronal; axial and sagittal; coronal and sagittal; and axial, coronal, and sagittal. Feature selection using the least absolute shrinkage and selection operator method and model construction using a support vector machine algorithm with k-fold cross-validation were performed. AUC was used to evaluate diagnostic performance. RESULTS: The AUC of visual analysis was 0.75. The model 'coronal and sagittal' had the highest AUC (0.98) amongst the seven combinations. The fivefold cross-validation for the model 'coronal and sagittal' showed AUCs of 0.85 and 0.97 in training and validation sets, respectively. The AUC of the model 'coronal and sagittal' for all subjects was significantly higher than that of visual analysis (0.98 vs. 0.75; p < 0.0001). CONCLUSION: The model 'coronal and sagittal' can accurately differentiate between the normal placenta and PAS, with a significantly better diagnostic performance than visual analysis. Texture analysis is an optimal method for differentiating between the normal placenta and PAS.

  56. Aphasic status epilepticus after glioma resection: two case reports. International-journal

    Yoshiteru Shimoda, Masayuki Kanamori, Ryuta Saito, Shinichiro Osawa, Shunji Mugikura, Teiji Tominaga

    Acta neurochirurgica　163　(11)　3109-3113　2021/11

    DOI： 10.1007/s00701-021-04984-z 　

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    Aphasic status epilepticus (ASE) is a subtype of focal nonconvulsive status epilepticus, in which language disturbance is the only objective clinical manifestation. We present two cases of patients who experienced delayed onset of temporal aphasia after the removal of glioma at the language-dominant hemisphere. In both cases, arterial spin labeling was useful for diagnosis and antiepileptic drug was effective. ASE should be considered a cause of persistent aphasia after glioma resection at or near the language area.

  57. Importance of ADC parameters from histogram analysis corresponding to histological components in endometrial cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    European journal of radiology　144　110004-110004　2021/11

    DOI： 10.1016/j.ejrad.2021.110004 　

  58. Indication of perfusion contrast-enhanced ultrasound for diagnosing lymph nodes.

    Naoko Mori, Shunji Mugikura, Kei Takase

    Japanese journal of radiology　39　(10)　1017-1018　2021/10

    DOI： 10.1007/s11604-021-01160-2 　

  59. Serial changes of T1-, T2-weighted MR imaging and MR spectroscopy in Tay-Sachs disease with late onset spasms. International-journal Peer-reviewed

    Shunji Mugikura, Naoko Mori, Shoki Takahashi

    Brain & development　43　(9)　975-976　2021/10

    DOI： 10.1016/j.braindev.2021.06.009 　

  60. Utility of histogram analysis for apparent diffusion coefficient values in evaluating the pathological characteristics of endometrial cancer. International-journal

    Naoko Mori, Shunji Mugikura, Kei Takase

    The British journal of radiology　20210928-20210928　2021/09/14

    DOI： 10.1259/bjr.20210928 　

  61. The possible difference ofunderlying pathophysiologies between "ivy sign" on contrast-enhanced mri and flair

    N. Mori, S. Mugikura

    American Journal of Neuroradiology　42　(9)　E69　2021/09/01

    DOI： 10.3174/ajnr.A7176 　

    ISSN： 0195-6108

    eISSN： 1936-959X

  62. The Possible Difference of Underlying Pathophysiologies between “Ivy Sign” on Contrast-Enhanced MRI and FLAIR

    N. Mori, S. Mugikura

    American Journal of Neuroradiology　2021/07/15

    Publisher: American Society of Neuroradiology ({ASNR})

    DOI： 10.3174/ajnr.A7176 　

    ISSN： 1936-959X

  63. Assessment of the sequential time–signal enhancement curve of dynamic contrast-enhanced MRI might be effective in diagnosing growth hormone-producing pituitary adenomas

    Naoko Mori, Shunji Mugikura, Kei Takase

    Japanese Journal of Radiology　2021/06/04

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-021-01146-0 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  64. Discriminating low-grade ductal carcinoma in situ (DCIS) from non-low-grade DCIS or DCIS upgraded to invasive carcinoma: effective texture features on ultrafast dynamic contrast-enhanced magnetic resonance imaging

    Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yo Oguma, Minami Hirasawa, Satoko Sato, Kei Takase

    Breast Cancer　2021/04/26

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12282-021-01257-6 　

    ISSN： 1340-6868

    eISSN： 1880-4233

  65. Value of ultrafast and standard dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the presence and extension of residual disease after neoadjuvant chemotherapy in breast cancer

    Erina Kato, Naoko Mori, Shunji Mugikura, Satoko Sato, Takanori Ishida, Kei Takase

    Japanese Journal of Radiology　2021/03/20

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11604-021-01110-y 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  66. Correction to: Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

    Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

    European radiology　31　(3)　1780-1781　2021/03

    DOI： 10.1007/s00330-020-07144-6 　

  67. Comparison between ultra-high-resolution computed tomographic angiography and conventional computed tomographic angiography in the visualization of the subcallosal artery. International-journal

    Yoshimichi Sato, Toshiki Endo, Shingo Kayano, Hitoshi Nemoto, Kazuki Shimada, Akira Ito, Hidenori Endo, Shunji Mugikura, Kuniyasu Niizuma, Teiji Tominaga

    Surgical neurology international　12　528-528　2021

    DOI： 10.25259/SNI_887_2021 　

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    Background: The subcallosal artery (ScA) is a single dominant artery arising from the anterior communicating artery. Its injury causes amnesia and cognitive disturbance. The conventional computed tomographic angiography (C-CTA) is a common evaluation method of the intracranial artery. However, to image tinny perforating arteries such as the ScA is technically demanding for C-CTA. The purpose of this study is to investigate whether the ultra-high-resolution CTA (UHR-CTA) could image the ScA better than C-CTA. UHR-CTA became available in clinical practice in 2017. Its novel features are the improvement of the detector system and a small X-ray focus. Methods: Between April 2019 and May 2020, 77 and 49 patients who underwent intracranial UHR-CTA and C-CTA, respectively, were enrolled in this study. Two board-certified neurosurgeons participated as observers to identify the ScA based on UHR-CTA and C-CTA images. Results: UHR-CTA and C-CTA detected the ScA in 56-58% and 30-40% of the patients, respectively. In visualization of the ScA, UHR-CTA was better than C-CTA (P < 0.05, Fisher's exact test). Between the two observers, the Cohen's kappa coefficient was 0.77 for UHR-CTA and 0.78 for C-CTA. Conclusions: UHR-CTA is a simple and accessible method to evaluate intracranial vasculature. Visualization of the ScA with UHR-CTA was better than that with C-CTA. The high quality of UHR-CTA could provide useful information in the neurosurgery field.

  68. Abnormal Findings on "T1WI or DWI or MRCP:" An Effective Boolean Interpretation Model in Discriminating Small Pancreatic Ductal Adenocarcinoma from Control Group. International-journal

    Hainan Ren, Naoko Mori, Minami Hirasawa, Shin Hamada, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Journal of clinical imaging science　11　54-54　2021

    DOI： 10.25259/JCIS_158_2021 　

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    Objectives: The objectives of the study was to evaluate the diagnostic performance of findings on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and magnetic resonance cholangiopancreatography (MRCP) separately and to identify an optimal Boolean interpretation model for discriminating patients with small pancreatic ductal adenocarcinoma (PDAC) from control groups in clinical practice. Material and Methods: We retrospectively enrolled 30 patients with surgery confirmed small PDAC (≤20 mm) and 302 patients without pancreatic abnormality between April 2008 and February 2020. The presence of masses was evaluated by T1WI, T2WI, and DWI. Abnormality of the main pancreatic duct (MPD) was evaluated by T2WI and MRCP. Multivariate logistic regression analysis was performed to select significant sequences for discriminating the small PDAC and control groups. Boolean operators "OR" or "AND" were used to construct sequence combinations. Diagnostic performances of these sequences and combinations were evaluated by X 2 tests. Results: The sensitivity of T2WI was lowest (20%) for detecting masses. For evaluating MPD abnormality, sensitivity was higher for MRCP than for T2WI (86.7% vs. 53.3%). Multivariate logistic regression analysis showed that T1WI and DWI for detecting the presence of masses and MRCP for evaluating MPD abnormality were significantly associated with differentiation between the two groups (P = 0.0002, P = 0.0484, and P < 0.0001, respectively). Seven combinations were constructed with T1WI, DWI, and MRCP. The combination of findings on "T1WI or DWI or MRCP" achieved the highest sensitivity of 96.7% and negative predictive value of 99.6%. Conclusion: The combination of findings on "T1WI or DWI or MRCP" might be an optimal interpretation model for discriminating small PDAC from control groups in clinical practice.

  69. 18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies. International-journal

    Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Michiko Kobayashi, Ohito Tano, Shun Ishiyama, Takaaki Nakamura, Ichiro Nakashima, Shunji Mugikura, Ren Iwata, Yasuyuki Taki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki

    Frontiers in aging neuroscience　13　761010-761010　2021

    DOI： 10.3389/fnagi.2021.761010 　

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    Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters. Methods: 18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke's Cognitive Examination-Revised, and Frontal Assessment Battery, Unified Parkinson's Disease Rating Scale Motor Score, and PSP Rating Scale. Results: 18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP. Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.

  70. Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade. International-journal

    Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase

    European radiology　31　(1)　55-64　2021/01

    DOI： 10.1007/s00330-020-07047-6 　

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    OBJECTIVES: The purpose of our study was to perform Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma, and to evaluate the relationship between histological grade and the ratios of the different clusters in each patient. METHODS: This retrospective study enrolled 122 patients (training: n = 63; and validation: n = 59) imaged between May 2015 and February 2020. In the training cohort, manual segmentation was performed on the ADC maps to obtain the ADC data of each patient, and these ADC data were summated to obtain the "All-patient" ADC data. Cluster analysis (three clusters) was performed on this All-patient ADC data, and the ADC ranges of each cluster were defined as follows: cluster 1, 490-699 × 10-6 mm2/s; cluster 2, 700-932 × 10-6 mm2/s; and cluster 3, over 933 × 10-6 mm2/s. In the training and validation cohorts, the ADC data of each patient was classified into three clusters according to these ADC ranges. The cluster ratios of each patient were calculated and compared with histological grade. RESULTS: In the training cohort, a significant positive correlation was found between the cluster 1 ratio and histological grade (ρ = 0.34, p = 0.0059). The cluster 1 ratios of high-grade lesions (grade 3) were significantly higher than those of low-grade lesions (grades 1 and 2) (p = 0.0084). A similar significant positive correlation was found between the cluster 1 ratio and histological grade in the validation cohort (ρ = 0.44, p = 0.0006). CONCLUSIONS: The cluster 1 ratio containing voxels with low ADC was significantly correlated with the histological grade of endometrioid carcinoma. KEY POINTS: • We performed Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma. • The cluster 1 ratio, which included low ADC values, was significantly positive correlated with histological grade in the training and validation cohorts. • The GMM-based cluster analysis of voxel-based ADC data was effective for grading endometrioid carcinoma.

  71. Distinctive lesions of brain MRI between MOG-antibody-associated and AQP4-antibody-associated diseases. International-journal Peer-reviewed

    Yuki Matsumoto, Tatsuro Misu, Shunji Mugikura, Yoshiki Takai, Shuhei Nishiyama, Hiroshi Kuroda, Toshiyuki Takahashi, Juichi Fujimori, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

    Journal of neurology, neurosurgery, and psychiatry　2020/12/30

    DOI： 10.1136/jnnp-2020-324818 　

  72. Combining MRI and genetic data in the Tohoku Medical Megabank Organization cohort study for innovative Alzheimer’s disease research

    Makiko Taira, Nobuo Fuse, Shunji Mugikura, Kengo Kinoshita, Masayuki Yamamoto

    Alzheimer's &amp; Dementia　16　(S10)　2020/12

    Publisher: Wiley

    DOI： 10.1002/alz.045688 　

    ISSN： 1552-5260

    eISSN： 1552-5279

  73. Diagnostic yield of seizure recordings and neuroimaging in patients with focal epilepsy without interictal epileptiform discharges Peer-reviewed

    Minori Suzuki, Kazutaka Jin, Yu Kitazawa, Mayu Fujikawa, Yosuke Kakisaka, Shiho Sato, Shunji Mugikura, Nobukazu Nakasato

    Epilepsy & Behavior　112　107468-107468　2020/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2020.107468 　

    ISSN： 1525-5050

  74. Effective apparent diffusion coefficient parameters for differentiation between mass-forming autoimmune pancreatitis and pancreatic ductal adenocarcinoma

    Hainan Ren, Naoko Mori, Shin Hamada, Chiaki Takasawa, Shunji Mugikura, Atsushi Masamune, Kei Takase

    Abdominal Radiology　2020/10/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00261-020-02795-x 　

    ISSN： 2366-004X

    eISSN： 2366-0058

  75. Resting state functional connectivity of the pain matrix and default mode network in irritable bowel syndrome: a graph theoretical analysis. International-journal Peer-reviewed

    Michiko Kano, Cecilia Grinsvall, Qian Ran, Patrick Dupont, Joe Morishita, Tomohiko Muratsubaki, Shunji Mugikura, Huynh Giao Ly, Hans Törnblom, Maria Ljungberg, Kei Takase, Magnus Simrén, Lukas Van Oudenhove, Shin Fukudo

    Scientific reports　10　(1)　11015-11015　2020/07/03

    DOI： 10.1038/s41598-020-67048-9 　

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    Irritable bowel syndrome (IBS) is a functional disorder of brain-gut interactions. Differential brain responses to rectal distention between IBS and healthy controls (HCs) have been demonstrated, particularly in the pain matrix and the default mode network. This study aims to compare resting-state functional properties of these networks between IBS patients and HCs using graph analysis in two independent cohorts. We used a weighted graph analysis of the adjacency matrix based on partial correlations between time series in the different regions in each subject to determine subject specific graph measures. These graph measures were normalized by values obtained in equivalent random networks. We did not find any significant differences between IBS patients and controls in global normalized graph measures, hubs, or modularity structure of the pain matrix and the DMN in any of our two independent cohorts. Furthermore, we did not find consistent associations between these global network measures and IBS symptom severity or GI-specific anxiety but we found a significant difference in the relationship between measures of psychological distress (anxiety and/or depressive symptoms) and normalized characteristic path length. The responses of these networks to visceral stimulation rather than their organisation at rest may be primarily disturbed in IBS.

  76. Turbo Spin-echo Diffusion-weighted Imaging Compared with Single-shot Echo-planar Diffusion-weighted Imaging: Image Quality and Diagnostic Performance When Differentiating between Ductal Carcinoma in situ and Invasive Ductal Carcinoma. Peer-reviewed

    Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yu Mori, Yui Maekawa, Tatsuo Nagasaka, Kei Takase

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　20　(1)　60-68　2020/03/06

    DOI： 10.2463/mrms.mp.2019-0195 　

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    PURPOSE: To compare the image quality between turbo spin-echo (TSE)-diffusion weighted imaging (DWI) and single-shot echo-planar imaging (EPI)-DWI, and to verify the diagnostic performance of the apparent diffusion coefficient (ADC) parameters of the two techniques by using histogram analysis in terms of differentiation between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions. METHODS: Ninety-four women with 94 lesions diagnosed as breast cancer by surgery underwent IRB-approved preoperative magnetic resonance imaging, including TSE and EPI-DWI with b-values of 50 and 850 s/mm2. Twenty lesions were identified as DCIS and 74 as IDC. Image quality [signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and geometric distortion] was evaluated quantitatively and compared between the TSE and EPI-DWI. A histogram analysis of the entire tumor voxel-based ADC data was performed, and the 10th, 25th, 50th, 75th, and 90th percentile values of each technique were compared between DCIS and IDC lesions. RESULTS: The SNR and CNR of TSE-DWI were significantly higher than those of EPI-DWI (P < 0.0001 and < 0.0001). The geometric distortion of TSE-DWI was significantly lower than that of EPI-DWI (P < 0.0001). In TSE-DWI, the 10th, 25th, 50th, and 75th percentile values were significantly different between the DCIS and IDC lesions (P = 0.0010, 0.0004, 0.0008, and 0.0044, respectively). In EPI-DWI, the 50th and 75th percentile values were significantly different between the two groups (P = 0.0009 and 0.0093). There was no significant difference in the area under the curve of the receiver operating characteristic analysis of the 10th, 25th, 50th, and 75th percentile values of TSE-DWI, and the 50th and 75th percentile values of EPI-DWI (P = 0.29). CONCLUSION: The image quality of TSE-DWI was better than that of EPI-DWI. DCIS lesions were distinguished from IDC lesions with a wider range of percentile values in TSE-DWI than in EPI-DWI, although diagnostic performance was not significantly different between the techniques.

  77. Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm Peer-reviewed

    Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

    Annals of Nuclear Medicine　34　(3)　220-227　2020/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12149-020-01436-z 　

    ISSN： 0914-7187

    eISSN： 1864-6433

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    <title>Abstract</title><sec> <title>Objective</title> Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. </sec><sec> <title>Methods</title> Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average <italic>Z</italic> score of the voxels with a <italic>Z</italic> score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity &gt; 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). </sec><sec> <title>Results</title> In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (<italic>ρ</italic>= −  0.884, <italic>p</italic> = 0.0007) or general MQ (<italic>ρ</italic> =− 0.853, <italic>p</italic> = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (<italic>ρ</italic> = − 0.769, <italic>p</italic> = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (<italic>ρ</italic> =  −  0.811, <italic>p</italic> = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. </sec><sec> <title>Conclusions</title> The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia. </sec>

  78. Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.

    Shunji Mugikura, Naoko Mori, Hirokazu Kikuchi, Etsuro Mori, Shoki Takahashi, Kei Takase

    Annals of nuclear medicine　34　(3)　220-227　2020/03

    DOI： 10.1007/s12149-020-01436-z 　

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    OBJECTIVE: Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia. METHODS: Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on 123I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. The Severity (average Z score of the voxels with a Z score that exceeds a threshold value of 2) was calculated. The cerebral lobes with rCBF exhibiting Severity > 2 in all patients were identified. In these lobes, we then examined whether there was a gyrus exhibiting Severity that was negatively related to memory quotients (MQs). RESULTS: In the right subcallosal gyrus, there was a significant negative correlation between Severity and visual MQ (ρ= -  0.884, p = 0.0007) or general MQ (ρ =- 0.853, p = 0.0017). In the right anterior cingulate gyrus, there was a significant negative correlation between Severity and verbal MQ (ρ = - 0.769, p = 0.0092). In the right rectal gyrus, there was a significant negative correlation between Severity and general MQ (ρ =  -  0.811, p = 0.0044). No significant correlations were found between Severity in other brain regions and verbal, visual, or general MQ. CONCLUSIONS: The decreased rCBF in the subcallosal gyrus included in the basal forebrain, anterior cingulate gyrus, and the rectal gyrus in the right hemisphere was related to postoperative amnesia.

  79. 大脳表在静脈への還流障害を来したサルコイドーシスの1例

    竹下 翔, 明石 敏昭, 佐藤 志帆, 北見 昌広, 村田 隆紀, 梅津 篤司, 麦倉 俊司, 高瀬 圭

    Japanese Journal of Radiology　38　(Suppl.)　1-1　2020/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  80. 軽傷頭部外傷後の患者の睡眠障害 受傷から1年間の後方視的調査

    八木橋 真央, 中川 敦寛, 佐久間 篤, 麦倉 俊司, 古谷 桂子, 工藤 大介, 刈部 博, 久志本 成樹, 富田 博秋, 冨永 悌二

    日本脳神経外傷学会プログラム・抄録集　43回　89-89　2020/02

    Publisher: (一社)日本脳神経外傷学会

  81. Prediction of Cerebral Hyperperfusion after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis by Three-Dimensional-Time-of-Flight Magnetic Resonance Angiography in Adult Patients with Moyamoya Disease. International-journal

    Taketo Nishizawa, Miki Fujimura, Masahito Katsuki, Shunji Mugikura, Ryosuke Tashiro, Kenichi Sato, Teiji Tominaga

    Cerebrovascular diseases (Basel, Switzerland)　49　(4)　396-403　2020

    DOI： 10.1159/000509740 　

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    INTRODUCTION: Superficial temporal artery (STA)-middle cerebral artery (MCA) anastomosis is an effective surgical procedure for adult patients with moyamoya disease (MMD) and is known to have the potential to prevent cerebral ischemia and/or hemorrhagic stroke. Cerebral hyperperfusion (CHP) syndrome is one of the serious complications of this procedure that can result in deleterious outcomes, such as delayed intracerebral hemorrhage, but the prediction of CHP before revascularization surgery remains challenging. The present study evaluated the diagnostic value of preoperative three-dimensional (3D)-time-of-flight (TOF) magnetic resonance angiography (MRA) for predicting CHP after STA-MCA anastomosis for MMD. MATERIALS AND METHODS: The signal intensity of the peripheral portion of the intracranial major arteries, such as the anterior cerebral artery (ACA), MCA, and posterior cerebral artery (PCA) ipsilateral to STA-MCA anastomosis, on preoperative MRA was graded (0-2 in each vessel) according to the ability to visualize each vessel on 97 affected hemispheres in 83 adult MMD patients. Local cerebral blood flow (CBF) at the site of anastomosis was quantitatively measured by N-isopropyl-p-[123I]-iodoamphetamine single-photon emission computed tomography 1 and 7 days after surgery, in addition to the preoperative CBF value at the corresponding area. Then, we investigated the correlation between the preoperative MRA score and the development of CHP. RESULTS: The CHP phenomenon 1 day after STA-MCA anastomosis (local CBF increase over 150% compared with the preoperative value) was evident in 27 patients (27/97 hemispheres; 28%). Among them, 8 (8 hemispheres) developed CHP syndrome. Multivariate analysis revealed that the hemispheric MRA score (0-6), the summed ACA, MCA, and PCA scores for the affected hemisphere, was significantly associated with the development of CHP syndrome (p = 0.011). The hemispheric MRA score was also significantly correlated with the CHP phenomenon, either symptomatic or asymptomatic (p < 0.001). CONCLUSION: The signal intensity of the intracranial major arteries, including the ACA, MCA, and PCA, on preoperative 3D-TOF MRA may identify adult MMD patients at higher risk for CHP after direct revascularization surgery.

  82. Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Yoji Yamashita, Kenichi Nagamatsu, Takaki Murata, Shunji Mugikura, Toshihiro Kumabe, Eva Wembacher-Schröder, Rowena Thomson, Teiji Tominaga

    Neuro-Oncology Advances　2　(1)　2020/01/01

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/noajnl/vdaa033 　

    eISSN： 2632-2498

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    <title>Abstract</title> <sec> <title>Background</title> Treatment options for patients suffering brainstem gliomas are quite limited as surgery is not an option against intrinsic tumors at brainstem and chemotherapy generally failed to demonstrate its efficacy. Intracerebral convection-enhanced delivery (CED) is a novel approach for administering chemotherapy to patients with brain tumors. We present the results of phase I trial of CED of nimustine hydrochloride (ACNU), designed to determine the maximum tolerable concentration of ACNU, for patients with recurrent brainstem gliomas. </sec> <sec> <title>Methods</title> Sixteen patients, aged 3–81 years old, suffering from recurrent brainstem gliomas, including diffuse intrinsic pontine glioma patients as well as patients with recurrent gliomas that originated from non-brainstem sites, were enrolled in this trial between February 2011 and April 2016. The dose/concentration escalation trial included 3 dose/concentration groups (0.25, 0.5, and 0.75 mg/mL, all at 7 mL) to determine the safety and tolerability of CED of ACNU. Real-time monitoring of drug distribution was performed by mixing gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA) in the infusion solution. CED of ACNU was given in combination with oral or intravenous temozolomide chemotherapy. </sec> <sec> <title>Results</title> CED of ACNU demonstrated antitumor activity, as assessed by radiographic changes and prolonged overall survival. The recommended dosage was 0.75 mg/mL. Drug-associated toxicity was minimal. </sec> <sec> <title>Conclusions</title> Intracerebral CED of ACNU under real-time monitoring of drug distribution, in combination with systemic temozolomide, was well tolerated among patients with recurrent brainstem gliomas. The safety and efficacy observed suggest the clinical benefits of this strategy against this devastating disease. Based on this phase I study, further clinical development of ACNU is warranted. </sec>

  83. Number of MRI T1-hypointensity corrected by T2/FLAIR lesion volume indicates clinical severity in patients with multiple sclerosis. International-journal Peer-reviewed

    Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Shunji Mugikura, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima

    PloS one　15　(4)　e0231225　2020

    DOI： 10.1371/journal.pone.0231225 　

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    INTRODUCTION: Progressive brain atrophy, development of T1-hypointense areas, and T2-fluid-attenuated inversion recovery (FLAIR)-hyperintense lesion formation in multiple sclerosis (MS) are popular volumetric data that are often utilized as clinical outcomes. However, the exact clinical interpretation of these volumetric data has not yet been fully established. METHODS: We enrolled 42 consecutive patients with MS who fulfilled the revised McDonald criteria of 2010. They were followed-up for more than 3 years from onset, and cross-sectional brain volumetry was performed. Patients with no brain lesions were excluded in advance from this study. For the brain volumetric data, we evaluated several parameters including age-adjusted gray-matter volume atrophy, age-adjusted white-matter volume atrophy, and T2-FLAIR lesion volume. The numbers of T1-hypointense and T2-FLAIR-hyperintense areas were also measured along the same timeline. The clinical data pertaining to disease duration, expanded disability status scale (EDSS), and MS severity score (MSSS) at the timing of volumetry were collected. RESULTS: Among the 42 patients with MS and brain lesions, the number of T1-hypointensity (rho = 0.51, p<0.001), gray-matter atrophy (rho = 0.40, p<0.01) and white-matter atrophy (rho = 0.49, p<0.001) correlated with the EDSS. T1-hypointensity count divided by FLAIR lesion volume correlated with the MSSS (rho = 0.60, p<0.001). Meanwhile, counts or volumes of FLAIR-hyperintense lesions were associated only with the times of past relapses, and did not correlate with present neurological disability level or ongoing disease activity. These findings were consistent regardless of the presence of spinal cord lesions. CONCLUSION: Numbers of T1-hypointensities and brain atrophy equally indicated the current neurological disability in MS. The number of T1-hypointensities divided by FLAIR lesion volume represented the clinical severity. The size or number of FLAIR lesions reflected earlier relapses but was not a good indicator of neurological disability or clinical severity.

  84. Significance of Quantitative Cerebral Blood Flow Measurement in the Acute Stage after Revascularization Surgery for Adult Moyamoya Disease: Implication for the Pathological Threshold of Local Cerebral Hyperperfusion. International-journal Peer-reviewed

    Masayuki Kameyama, Miki Fujimura, Ryosuke Tashiro, Kenichi Sato, Hidenori Endo, Kuniyasu Niizuma, Shunji Mugikura, Teiji Tominaga

    Cerebrovascular diseases (Basel, Switzerland)　48　(3-6)　217-225　2020/01

    DOI： 10.1159/000504835 　

    ISSN： 1015-9770

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    OBJECTIVE: Superficial temporal artery (STA)-middle cerebral artery (MCA) anastomosis is a standard surgical procedure for adult patients with moyamoya disease (MMD) and plays a role in preventing ischemic and/or hemorrhagic stroke. Cerebral hyperperfusion (CHP) syndrome is a potential complication of this procedure that can result in deleterious outcomes, such as delayed intracerebral hemorrhage, but the exact threshold of the pathological increase in postoperative cerebral blood flow (CBF) is unclear. Thus, we analyzed local CBF in the acute stage after revascularization surgery for adult MMD to predict CHP syndrome under modern perioperative management. MATERIALS AND METHODS: Fifty-nine consecutive adult MMD patients, aged 17-66 years old (mean 43.1), underwent STA-MCA anastomosis with indirect pial synangiosis for 65 affected hemispheres. All patients were perioperatively managed by strict blood pressure control (systolic pressure of 110-130 mm Hg) to prevent CHP syndrome. Local CBF at the site of anastomosis was quantitatively measured using the autoradiographic method by N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography 1 and 7 days after surgery, in addition to the preoperative CBF value at the corresponding area. We defined CHP phenomenon as a local CBF increase over 150% compared to the preoperative value. Then, we investigated the correlation between local hemodynamic change and the development of CHP syndrome. RESULTS: After 65 surgeries, 5 patients developed CHP syndrome, including 2 patients with delayed intracerebral hemorrhage (3.0%), 1 with symptomatic subarachnoid hemorrhage (1.5%), and 2 with focal neurological deterioration without hemorrhage. The CBF increase ratio was significantly higher in patients with CHP syndrome (270.7%) than in patients without CHP syndrome (135.2%, p = 0.003). Based on receiver operating characteristic analysis, the cutoff value for the pathological postoperative CBF increase ratio was 184.5% for CHP syndrome (sensitivity = 83.3%, specificity =  94.2%, area under the curve [AUC] value  =  0.825) and 241.3% for hemorrhagic CHP syndrome (sensitivity =  75.0%, specificity =  97.2%, AUC value  =  0.742). CONCLUSION: Quantitative measurement of the local CBF value in the early postoperative period provides essential information to predict CHP syndrome after STA-MCA anastomosis in patients with adult MMD. The pathological threshold of hemorrhagic CHP syndrome was as high as 241.3% by the local CBF increase ratio, but 2 patients (3.0%) developed delayed intracerebral hemorrhage in this series that were managed following the intensive perioperative management protocol. Thus, we recommend routine CBF measurement in the acute stage after direct revascularization surgery for adult MMD and satisfactory blood pressure control to avoid the deleterious effects of CHP.

  85. Insula activity to visceral stimulation and endocrine stress responses as associated with alexithymia in patients with irritable bowel syndrome. Peer-reviewed

    Kano M, Muratsubaki T, Yagihashi M, Morishita J, Mugikura S, Dupont P, Takase K, Kanazawa M, Van Oudenhove L, Fukudo S

    Psychosomatic medicine　2019/10

    DOI： 10.1097/PSY.0000000000000729 　

    ISSN： 0033-3174

  86. Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity. Peer-reviewed

    Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　2019/07

    DOI： 10.2463/mrms.mp.2019-0026 　

    ISSN： 1347-3182

  87. Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density Peer-reviewed

    Naoko Mori, Hiroyuki Abe, Shunji Mugikura, Chiaki Takasawa, Satoko Sato, Minoru Miyashita, Yu Mori, Federico D. Pineda, Gregory S. Karczmar, Hajime Tamura, Shoki Takahashi, Kei Takase

    Academic Radiology　26　(7)　e141-e149　2019/07

    DOI： 10.1016/j.acra.2018.08.016 　

    ISSN： 1076-6332

    eISSN： 1878-4046

  88. Parasympathetic activity correlates with subjective and brain responses to rectal distension in healthy subjects but not in non-constipated patients with irritable bowel syndrome. Peer-reviewed

    Kano M, Yoshizawa M, Kono K, Muratsubaki T, Morishita J, Van Oudenhove L, Yagihashi M, Mugikura S, Dupont P, Takase K, Kanazawa M, Fukudo S

    Scientific reports　9　(1)　7358　2019/05

    DOI： 10.1038/s41598-019-43455-5 　

  89. Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer Peer-reviewed

    Naoko Mori, Shunji Mugikura, Minoru Miyashita, Yumiko Kudo, Mikiko Suzuki, Li Li, Yu Mori, Shoki Takahashi, Kei Takase

    Japanese Journal of Radiology　37　(2)　145-153　2019/02/20

    DOI： 10.1007/s11604-018-0792-6 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  90. The relationship between the arterial geometry and wall shear stress in the vertebrobasilar system

    Fangjia Pan, Hitomi Anzai, Shunji Mugikura, Ko Kitamura, Makoto Ohta

    ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)　3　2019

    Publisher: American Society of Mechanical Engineers (ASME)

    DOI： 10.1115/IMECE2019-10866 　

  91. Longitudinal changes in 18F-THK5351 positron emission tomography in corticobasal syndrome

    M. Ezura, A. Kikuchi, A. Ishiki, N. Okamura, T. Hasegawa, R. Harada, S. Watanuki, Y. Funaki, K. Hiraoka, T. Baba, N. Sugeno, R. Oshima, S. Yoshida, J. Kobayashi, M. Kobayashi, O. Tano, I. Nakashima, S. Mugikura, R. Iwata, Y. Taki, K. Furukawa, H. Arai, S. Furumoto, M. Tashiro, K. Yanai, Y. Kudo, A. Takeda, M. Aoki

    European Journal of Neurology　26　(9)　1205-1211　2019

    DOI： 10.1111/ene.13966 　

    ISSN： 1351-5101

    eISSN： 1468-1331

  92. Validating an Empirical Mathematical Model for Dynamic Contrast-enhanced MR Imaging of Hand and Wrist Synovitis in Rheumatoid Arthritis: Correlation of Model Parameters with Clinical Disease Activity Peer-reviewed

    Ochi J, Mori N, Mori Y, Mugikura S, Hitachi S, Itoi E, Takase K

    Magnetic Resonance in Medical Sciences　2019

    DOI： 10.2463/mrms.mp.2019-0026 　

    ISSN： 1880-2206

  93. Atrophy of the ipsilateral mammillary body in unilateral hippocampal sclerosis shown by thin-slice-reconstructed volumetric analysis. Peer-reviewed

    Morishita Y, Mugikura S, Mori N, Tamura H, Sato S, Akashi T, Jin K, Nakasato N, Takase K

    Neuroradiology　61　(5)　515-523　2019/01

    DOI： 10.1007/s00234-019-02158-4 　

    ISSN： 0028-3940

    eISSN： 1432-1920

  94. Incidence and Risk Factors of the Watershed Shift Phenomenon after Superficial Temporal Artery-Middle Cerebral Artery Anastomosis for Adult Moyamoya Disease. International-journal Peer-reviewed

    Ryosuke Tashiro, Miki Fujimura, Masayuki Kameyama, Shunji Mugikura, Hidenori Endo, Yohei Takeuchi, Yasutake Tomata, Kuniyasu Niizuma, Teiji Tominaga

    Cerebrovascular diseases (Basel, Switzerland)　47　(3-4)　178-187　2019

    DOI： 10.1159/000500802 　

    ISSN： 1015-9770

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    OBJECTIVE: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard surgical management for adult moyamoya disease (MMD) patients, but local cerebral hyperperfusion (CHP) and cerebral ischemia are potential complications of this procedure. Recent hemodynamic analysis of the acute stage after revascularization surgery for MMD revealed a more complex and unique pathophysiological condition, the so-called "watershed shift (WS) phenomenon," which is defined as a paradoxical decrease in the cerebral blood flow (CBF) at the adjacent cortex near the site of local CHP. The objective of this study was to clarify the exact incidence, clinical presentation, and risk factors of the WS phenomenon after direct revascularization surgery for adult MMD. PATIENTS AND METHODS: Among 74 patients with MMD undergoing STA-MCA anastomosis for 78 affected hemispheres, 60 adult patients comprising 64 hemispheres underwent serial quantitative CBF analysis by N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography after revascularization surgery. The local CBF was quantitatively measured at the site of anastomosis and the adjacent cortex before surgery, as well as on 1 and 7 days after surgery. Then, we investigated the incidence, clinical presentation, and risk factors of the WS phenomenon. RESULTS: The WS phenomenon was evident in 7 patients (7/64 hemispheres; 10.9%) after STA-MCA anastomosis for adult MMD. None of the patients developed neurological deterioration due to the WS phenomenon, but 1 patient developed reversible ischemic change on diffusion-weighted imaging at the site of the WS phenomenon. Multivariate analysis revealed that a lower preoperative CBF value was significantly associated with the occurrence of the WS phenomenon (20.3 ± 7.70 mL/100 g/min in WS-positive group vs. 31.7 ± 8.81 mL/100 g/min in WS-negative group, p= 1.1 × 10-2). CONCLUSIONS: The incidence of the WS phenomenon was as high as 10.9% after STA-MCA anastomosis for adult MMD. The clinical outcome of the WS phenomenon is generally favorable, but there is a potential risk for perioperative cerebral infarction. Thus, we recommend routine CBF measurement in the acute stage after revascularization surgery for adult MMD to avoid surgical complications, such as local CHP and cerebral ischemia, caused by the WS phenomenon. Concomitant detection of the WS phenomenon with local CHP is clinically important because blood pressure reduction to counteract local CHP may have to be avoided in the presence of the WS phenomenon.

  95. Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI. Peer-reviewed

    Shibahara I, Saito R, Osada Y, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Tominaga T

    Journal of neuro-oncology　141　(2)　337-345　2018/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11060-018-03036-4 　

    ISSN： 0167-594X

    eISSN： 1573-7373

  96. Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury. International-journal Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi, Kei Takase

    Journal of neurosurgery　129　(5)　1317-1324　2018/11/01

    DOI： 10.3171/2017.6.JNS17466 　

    ISSN： 0022-3085

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    OBJECTIVEThe objective of this study was to test the hypothesis that midline (interhemispheric or perimesencephalic) traumatic subarachnoid hemorrhage (tSAH) on initial CT may implicate the same shearing mechanism that underlies severe diffuse axonal injury (DAI).METHODSThe authors enrolled 270 consecutive patients (mean age [± SD] 43 ± 23.3 years) with a history of head trauma who had undergone initial CT within 24 hours and brain MRI within 30 days. Six initial CT findings, including intraventricular hemorrhage (IVH) and tSAH, were used as candidate predictors of DAI. The presence of tSAH was determined at the cerebral convexities, sylvian fissures, sylvian vallecula, cerebellar folia, interhemispheric fissure, and perimesencephalic cisterns. Following MRI, patients were divided into negative and positive DAI groups, and were assigned to a DAI stage: 1) stage 0, negative DAI; 2) stage 1, DAI in lobar white matter or cerebellum; 3) stage 2, DAI involving the corpus callosum; and 4) stage 3, DAI involving the brainstem. Glasgow Outcome Scale-Extended (GOSE) scores were obtained in 232 patients.RESULTSOf 270 patients, 77 (28.5%) had DAI; tSAH and IVH were independently associated with DAI (p < 0.05). Of tSAH locations, midline tSAH was independently associated with both overall DAI and DAI stage 2 or 3 (severe DAI; p < 0.05). The midline tSAH on initial CT had sensitivity of 60.8%, specificity of 81.7%, and positive and negative predictive values of 43.7% and 89.9%, respectively, for severe DAI. When adjusted for admission Glasgow Coma Score, the midline tSAH independently predicted poor GOSE score at both hospital discharge and after 6 months.CONCLUSIONSMidline tSAH could implicate the same shearing mechanism that underlies severe DAI, for which midline tSAH on initial CT is a probable surrogate.

  97. Fast Temporal Resolution Dynamic Contrast-Enhanced MRI: Histogram Analysis Versus Visual Analysis for Differentiating Benign and Malignant Breast Lesions. Peer-reviewed

    Mori N, Pineda FD, Tsuchiya K, Mugikura S, Takahashi S, Karczmar GS, Abe H

    AJR. American journal of roentgenology　211　(4)　933-939　2018/10

    DOI： 10.2214/AJR.17.19225 　

    ISSN： 0361-803X

  98. Diagnostic value of electric properties tomography (EPT) for differentiating benign from malignant breast lesions: comparison with standard dynamic contrast-enhanced MRI. Peer-reviewed

    Mori N, Tsuchiya K, Sheth D, Mugikura S, Takase K, Katscher U, Abe H

    European radiology　2018/09

    DOI： 10.1007/s00330-018-5708-4 　

    ISSN： 0938-7994

  99. Paradoxical Association of Symptomatic Local Vasogenic Edema with Global Cerebral Hypoperfusion after Direct Revascularization Surgery for Adult Moyamoya Disease. International-journal Peer-reviewed

    Tashiro R, Fujimura M, Mugikura S, Niizuma K, Endo H, Endo T, Tominaga T

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　27　(8)　e172-e176　2018/08

    DOI： 10.1016/j.jstrokecerebrovasdis.2018.03.002 　

    ISSN： 1052-3057

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    BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres. Eight hours after the operation, the patient developed neurological deterioration of dysarthria and mono-paresis in her right hand. Magnetic resonance (MR) angiography showed apparently patent STA-MCA bypass, whereas MR imaging of fluid-attenuated inversion recovery demonstrated a local high-signal-intensity lesion at the vascular territory supplied by the bypass. The apparent diffusion coefficient value was significantly increased in this lesion, suggesting local vasogenic edema formation. N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography revealed global hypoperfusion in the left hemisphere. The administration of a free-radical scavenger and antiepileptic agent gradually relieved her symptoms, and MR imaging 1 month after surgery confirmed the complete disappearance of local vasogenic edema. CONCLUSIONS: Vasogenic edema may be associated not only with cerebral hyperperfusion but also with hypoperfusion after STA-MCA anastomosis for MMD. Although the exact mechanism of this rare association is unknown, the intrinsic vulnerability of intracranial vascular wall structures and the increased vascular permeability in MMD may partly explain the paradoxical association of hypoperfusion and local vasogenic edema.

  100. Relationship Between Perforator Infarction and Patient Outcomes After Surgical Treatment of Ruptured Anterior Communicating Artery Aneurysms. Peer-reviewed

    Mugikura S, Fujimura M, Takahashi S, Takase K

    World neurosurgery　113　390-391　2018/05

    DOI： 10.1016/j.wneu.2018.01.161 　

    ISSN： 1878-8750

  101. Relationship between ischemic injury and patient outcomes after surgical or endovascular treatment of ruptured anterior communicating artery aneurysms

    S. Mugikura, S. Takahashi, K. Takase

    American Journal of Neuroradiology　39　(4)　E51-E52　2018/04/01

    Publisher: American Society of Neuroradiology

    DOI： 10.3174/ajnr.A5564 　

    ISSN： 1936-959X 0195-6108

  102. Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm: a causal relationship with postoperative amnesia and long-term outcome Peer-reviewed

    Shunji Mugikura, Hirokazu Kikuchi, Miki Fujimura, Etsuro Mori, Shoki Takahashi, Kei Takase

    Japanese Journal of Radiology　36　(2)　81-89　2018/02/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s11604-017-0703-2 　

    ISSN： 1867-108X 1867-1071

  103. Time to Face the Nightmare That Has Plagued Neurosurgeons for Years: Memory Impairment from Postsurgery Subcallosal Artery Infarction for Anterior Communicating Artery Aneurysms International-journal

    Shunji Mugikura, Shoki Takahashi, Kei Takase

    World Neurosurgery　121　280-281　2018/01/01

    DOI： 10.1016/j.wneu.2018.08.224 　

    ISSN： 1878-8750

  104. Letter by Mugikura and Takahashi Regarding Article, "Ischemic Amnesia: Causes and Outcome". Peer-reviewed

    Mugikura S, Takahashi S

    Stroke　49　(1)　e14　2018/01

    DOI： 10.1161/STROKEAHA.117.019366 　

    ISSN： 0039-2499

  105. Primary blast-induced traumatic brain injury: lessons from lithotripsy

    A. Nakagawa, K. Ohtani, R. Armonda, H. Tomita, A. Sakuma, S. Mugikura, K. Takayama, S. Kushimoto, T. Tominaga

    SHOCK WAVES　27　(6)　863-878　2017/11

    DOI： 10.1007/s00193-017-0753-5 　

    ISSN： 0938-1287

    eISSN： 1432-2153

  106. Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients With Irritable Bowel Syndrome Peer-reviewed

    Michiko Kano, Tomohiko Muratsubaki, Joe Morishita, Keiji Kono, Shunji Mugikura, Kei Takase, Huynh Giao Ly, Patrick Dupont, Lukas Van Oudenhove, Shin Fukudo

    PSYCHOSOMATIC MEDICINE　79　(9)　988-999　2017/11

    DOI： 10.1097/PSY.0000000000000484 　

    ISSN： 0033-3174

    eISSN： 1534-7796

  107. Fear of linear gadolinium-based contrast agents and the Japanese radiologist's choice Peer-reviewed

    Shunji Mugikura, Kei Takase

    JAPANESE JOURNAL OF RADIOLOGY　35　(11)　695-696　2017/11

    DOI： 10.1007/s11604-017-0682-3 　

    ISSN： 1867-1071

    eISSN： 1867-108X

  108. Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome Peer-reviewed

    Michiko Kano, Tomohiko Muratsubaki, Lukas Van Oudenhove, Joe Morishita, Makoto Yoshizawa, Keiji Kohno, Mao Yagihashi, Yukari Tanaka, Shunji Mugikura, Patrick Dupont, Huynh Giao Ly, Kei Takase, Motoyori Kanazawa, Shin Fukudo

    SCIENTIFIC REPORTS　7　(1)　12425　2017/09

    DOI： 10.1038/s41598-017-09635-x 　

    ISSN： 2045-2322

  109. Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions Peer-reviewed

    Toshiaki Akashi, Shoki Takahashi, Shunji Mugikura, Shiho Sato, Takaki Murata, Atsushi Umetsu, Kei Takase

    AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W160-W168　2017/08

    DOI： 10.2214/AJR.16.17231 　

    ISSN： 0361-803X

    eISSN： 1546-3141

  110. For Whom Should We Write a Radiology Report, an Attending Physician or a Patient? Peer-reviewed

    Shunji Mugikura, Keisei Fujimori, Kei Takase

    AMERICAN JOURNAL OF ROENTGENOLOGY　209　(3)　W199-W199　2017/08

    DOI： 10.2214/AJR.17.18150 　

    ISSN： 0361-803X

    eISSN： 1546-3141

  111. Further Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan

    Shunji Mugikura, Miki Fujimura, Shoki Takahashi, Kei Takase

    RADIOLOGY　284　(1)　301-302　2017/07

    DOI： 10.1148/radiol.2017170252 　

    ISSN： 0033-8419

  112. Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the 'watershed shift' Peer-reviewed

    Xian-kun Tu, Miki Fujimura, Sherif Rashad, Shunji Mugikura, Hiroyuki Sakata, Kuniyasu Niizuma, Teiji Tominaga

    NEUROSURGICAL REVIEW　40　(3)　507-512　2017/07

    DOI： 10.1007/s10143-017-0845-9 　

    ISSN： 0344-5607

    eISSN： 1437-2320

  113. Whole brain and grey matter volume of Japanese patients with multiple sclerosis Peer-reviewed

    Tetsuya Akaishi, Ichiro Nakashima, Shunji Mugikura, Masashi Aoki, Kazuo Fujihara

    JOURNAL OF NEUROIMMUNOLOGY　306　68-75　2017/05

    DOI： 10.1016/j.jneuroim.2017.03.009 　

    ISSN： 0165-5728

    eISSN： 1872-8421

  114. Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density Peer-reviewed

    Naoko Mori, Shunji Mugikura, Shoki Takahashi, Koichi Ito, Chiaki Takasawa, Li Li, Minoru Miyashita, Atsuko Kasajima, Yu Mori, Takanori Ishida, Tetsuya Kodama, Kei Takase

    Ultrasound in Medicine and Biology　43　(3)　607-614　2017/03/01

    DOI： 10.1016/j.ultrasmedbio.2016.11.009 　

    ISSN： 0301-5629

    eISSN： 1879-291X

  115. Hypoxia-like Tissue Injury and Glial Response Contribute to the Development of Balo's Concentric Demyelination

    Y. Takai, T. Misu, S. Nishiyama, H. Ono, H. Kuroda, I. Nakashima, R. Saito, M. Kanamori, S. Mugikura, M. Watanabe, M. Aoki, K. Fujihara

    MULTIPLE SCLEROSIS JOURNAL　23　(2)　349-350　2017/02

    ISSN： 1352-4585

    eISSN： 1477-0970

  116. Endovascular Treatment of Hepatic Artery Pseudoaneurysm after Pancreaticoduodenectomy: Risk Factors Associated with Mortality and Complications Peer-reviewed

    Tetsuya Hasegawa, Hideki Ota, Tomonori Matsuura, Kazumasa Seiji, Shunji Mugikura, Fuyuhiko Motoi, Michiaki Unno, Kei Takase

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY　28　(1)　50-59　2017/01

    DOI： 10.1016/j.jvir.2016.04.004 　

    ISSN： 1051-0443

    eISSN： 1535-7732

  117. Hypoxia-like tissue injury and glial response contribute to Balo concentric lesion development Peer-reviewed

    Yoshiki Takai, Tatsuro Misu, Shuhei Nishiyama, Hirohiko Ono, Hiroshi Kuroda, Ichiro Nakashima, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Shunji Mugikura, Mika Watanabe, Masashi Aoki, Kazuo Fujihara

    NEUROLOGY　87　(19)　2000-2005　2016/11

    DOI： 10.1212/WNL.0000000000003308 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  118. In vivo visualization of tau deposits in corticobasal syndrome by F-18-THK5351 PET Peer-reviewed

    Akio Kikuchi, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima, Shun Yoshida, Junpei Kobayashi, Michinori Ezura, Michiko Kobayashi, Ohito Tano, Shunji Mugikura, Ren Iwata, Aiko Ishiki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki

    NEUROLOGY　87　(22)　2309-2316　2016/11

    DOI： 10.1212/WNL.0000000000003375 　

    ISSN： 0028-3878

    eISSN： 1526-632X

  119. T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus Peer-reviewed

    Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato

    EPILEPSY RESEARCH　126　1-9　2016/10

    DOI： 10.1016/j.eplepsyres.2016.06.001 　

    ISSN： 0920-1211

    eISSN： 1872-6844

  120. Different etiologies and prognoses of optic neuritis in demyelinating diseases Peer-reviewed

    Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Kimihiko Kaneko, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

    JOURNAL OF NEUROIMMUNOLOGY　299　152-157　2016/10

    DOI： 10.1016/j.jneuroim.2016.09.007 　

    ISSN： 0165-5728

    eISSN： 1872-8421

  121. Ischemic pituitary adenoma apoplexy-Clinical appearance and prognosis after surgical intervention Peer-reviewed

    Yoshikazu Ogawa, Kuniyasu Niizuma, Shunji Mugikura, Teiji Tominaga

    CLINICAL NEUROLOGY AND NEUROSURGERY　148　142-146　2016/09

    DOI： 10.1016/j.clineuro.2016.07.013 　

    ISSN： 0303-8467

    eISSN： 1872-6968

  122. GENDER DIFFERENCES IN VENTROMEDIAL PREFRONTAL CORTEX ACTIVITY ASSOCIATED WITH VALUATION OF FACES Peer-reviewed

    Ayahito Ito, Toshikatsu Fujii, Nobuhito Abe, Iori Kawasaki, Akiko Hayashi, Aya Ueno, Kazuki Yoshida, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    NEUROSCIENCE　328　194-200　2016/07

    DOI： 10.1016/j.neuroscience.2016.04.047 　

    ISSN： 0306-4522

    eISSN： 1873-7544

  123. Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries Peer-reviewed

    Takatsugu Abe, Miki Fujimura, Shunji Mugikura, Hidenori Endo, Teiji Tominaga

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　25　(6)　E79-E82　2016/06

    DOI： 10.1016/j.jstrokecerebrovasdis.2016.03.024 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  124. Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan Peer-reviewed

    Shunji Mugikura, Miki Fujimura, Shoki Takahashi

    RADIOLOGY　279　(2)　652-653　2016/05

    DOI： 10.1148/radiol.2016152305 　

    ISSN： 0033-8419

  125. Lesion length of optic neuritis impacts visual prognosis in neuromyelitis optica Peer-reviewed

    Tetsuya Akaishi, Ichiro Nakashima, Takayuki Takeshita, Shunji Mugikura, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Shuhei Nishiyama, Kazuhiro Kurosawa, Tatsuro Misu, Toru Nakazawa, Masashi Aoki, Kazuo Fujihara

    JOURNAL OF NEUROIMMUNOLOGY　293　28-33　2016/04

    DOI： 10.1016/j.jneuroim.2016.02.004 　

    ISSN： 0165-5728

    eISSN： 1872-8421

  126. Erratum to: Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer [Eur Radiol, DOI 10.1007/s00330-015-3847-4] Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    European Radiology　26　(2)　340-341　2016/02/01

    Publisher: Springer Verlag

    DOI： 10.1007/s00330-015-3888-8 　

    ISSN： 1432-1084 0938-7994

    eISSN： 1432-1084

  127. Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    EUROPEAN RADIOLOGY　26　(2)　331-339　2016/02

    DOI： 10.1007/s00330-015-3847-4 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  128. Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer (vol 26, pg 331, 2016) Peer-reviewed

    Naoko Mori, Shunji Mugikura, Chiaki Takasawa, Minoru Miyashita, Akiko Shimauchi, Hideki Ota, Takanori Ishida, Atsuko Kasajima, Kei Takase, Tetsuya Kodama, Shoki Takahashi

    EUROPEAN RADIOLOGY　26　(2)　340-341　2016/02

    DOI： 10.1007/s00330-015-3888-8 　

    ISSN： 0938-7994

    eISSN： 1432-1084

  129. Differential activation of the ventromedial prefrontal cortex between male and female givers of social reputation Peer-reviewed

    Iori Kawasaki, Ayahito Ito, Toshikatsu Fujii, Aya Ueno, Kazuki Yoshida, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    NEUROSCIENCE RESEARCH　103　27-33　2016/02

    DOI： 10.1016/j.neures.2015.07.010 　

    ISSN： 0168-0102

    eISSN： 1872-8111

  130. Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Kei Takase, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

    SPRINGERPLUS　5　176　2016/02

    DOI： 10.1186/s40064-016-1781-9 　

    ISSN： 2193-1801

  131. Medial temporal lobe activity associated with the successful retrieval of destination memory Peer-reviewed

    Shunji Mugikura, Nobuhito Abe, Ayahito Ito, Iori Kawasaki, Aya Ueno, Shoki Takahashi, Toshikatsu Fujii

    EXPERIMENTAL BRAIN RESEARCH　234　(1)　95-104　2016/01

    DOI： 10.1007/s00221-015-4415-5 　

    ISSN： 0014-4819

    eISSN： 1432-1106

  132. Altered white matter metabolism in delayed neurologic sequelae after carbon monoxide poisoning: A proton magnetic resonance spectroscopic study Peer-reviewed

    Hiroshi Kuroda, Kazuo Fujihara, Shunji Mugikura, Shoki Takahashi, Shigeki Kushimoto, Masashi Aoki

    JOURNAL OF THE NEUROLOGICAL SCIENCES　360　161-169　2016/01

    DOI： 10.1016/j.jns.2015.12.006 　

    ISSN： 0022-510X

    eISSN： 1878-5883

  133. Fornix Infarction due to Involvement of Posterior Circulation Peer-reviewed

    Shunji Mugikura, Shoki Takahashi

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(12)　2883-2885　2015/12

    DOI： 10.1016/j.jstrokecerebrovasdis.2015.07.009 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  134. Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly Peer-reviewed

    Tomomi Oikawa, Yasuko Tatewaki, Takaki Murata, Yumiko Kato, Shunji Mugikura, Kei Takase, Shoki Takahashi

    Neuroradiology Journal　28　(6)　628-633　2015/12/01

    Publisher: SAGE Publications Inc.

    DOI： 10.1177/1971400915609334 　

    ISSN： 1971-4009

  135. A comparative study of the extent of cerebral microvascular injury following whole-brain irradiation versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors Peer-reviewed

    Li Li, Shunji Mugikura, Toshihiro Kumabe, Takaki Murata, Etsuro Mori, Kei Takase, Keiichi Jingu, Shoki Takahashi

    RADIOTHERAPY AND ONCOLOGY　117　(2)　302-307　2015/11

    DOI： 10.1016/j.radonc.2015.09.017 　

    ISSN： 0167-8140

  136. Infarction in the pars libera of the column of fornix including pre (cholinergic)- and post (circuit of Papez fiber tracts)-commissural fibers causes "basal forebrain" amnesia Peer-reviewed

    Shunji Mugikura, Shoki Takahashi

    NEURORADIOLOGY　57　(7)　757-759　2015/07

    DOI： 10.1007/s00234-015-1504-x 　

    ISSN： 0028-3940

    eISSN： 1432-1920

  137. Local Vasogenic Edema without Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease Peer-reviewed

    Hiroyuki Sakata, Miki Fujimura, Shunji Mugikura, Kenichi Sato, Teiji Tominaga

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　24　(7)　E179-E184　2015/07

    DOI： 10.1016/j.jstrokecerebrovasdis.2015.03.050 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  138. [6. Diagnostic imaging for brain tumor]. Invited Peer-reviewed

    Takahashi S, Mugikura S, Kato Y, Takanami K, Higano S, Kurihara N

    Nihon Hoshasen Gijutsu Gakkai zasshi　71　(5)　468-480　2015/05

    DOI： 10.6009/jjrt.2015_JSRT_71.5.468 　

    ISSN： 0369-4305

  139. Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Yumiko Kato, Yasuko Tatewaki, Li Li, Kei Takase, Kiyoshi Ishii, Shigeki Kushimoto, Teiji Tominaga, Shoki Takahashi

    JOURNAL OF NEUROTRAUMA　32　(5)　359-365　2015/03

    DOI： 10.1089/neu.2014.3453 　

    ISSN： 0897-7151

    eISSN： 1557-9042

  140. Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism Peer-reviewed

    Hiroshi Kunikata, Naoko Aizawa, Masataka Kudo, Shunji Mugikura, Fumihiko Nitta, Ryo Morimoto, Yoshitsugu Iwakura, Yoshikiyo Ono, Fumitoshi Satoh, Hidetoshi Takahashi, Sadayoshi Ito, Shoki Takahashi, Toru Nakazawa

    PLOS ONE　10　(2)　e0117452　2015/02

    DOI： 10.1371/journal.pone.0117452 　

    ISSN： 1932-6203

  141. 4. Diseases of the brain 4: imaging in cerebrovascular diseases. Peer-reviewed

    Takahashi S, Mugikura S, Murata T, Kato Y, Tatewaki Y, Higano S, Kurihara N, Kinoshita T

    Nihon Hoshasen Gijutsu Gakkai zasshi　71　(2)　117-131　2015/02

    DOI： 10.6009/jjrt.2015_JSRT_71.2.117 　

    ISSN： 0369-4305

  142. Luminal-Type Breast Cancer: Correlation of Apparent Diffusion Coefficients with the Ki-67 Labeling Index Peer-reviewed

    Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Takanori Ishida, Gou Watanabe, Hiroshi Tada, Mika Watanabe, Kei Takase, Shoki Takahashi

    RADIOLOGY　274　(1)　66-73　2015/01

    DOI： 10.1148/radiol.14140283 　

    ISSN： 0033-8419

  143. Cortical Microvascularization and Leptomeningeal Collaterals in Moyamoya Disease Peer-reviewed

    Shunji Mugikura, Miki Fujimura, Shoki Takahashi

    EUROPEAN NEUROLOGY　73　(5-6)　351-352　2015

    DOI： 10.1159/000430811 　

    ISSN： 0014-3022

    eISSN： 1421-9913

  144. MR Imaging of Subcallosal Artery Infarct Causing Amnesia after Surgery for Anterior Communicating Artery Aneurysm

    S. Mugikura, H. Kikuchi, T. Fujii, T. Murata, K. Takase, E. Mori, S. Marinkovic, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　35　(12)　2293-2301　2014/12

    DOI： 10.3174/ajnr.A4057 　

    ISSN： 0195-6108

    eISSN： 1936-959X

  145. Neural basis of dishonest choices for harmful and helpful stories

    Nobuhito Abe, Toshikatsu Fujii, Ayahito Ito, Aya Ueno, Yuta Koseki, Ryusaku Hashimoto, Akiko Hayashi, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY　94　(2)　252-252　2014/11

    DOI： 10.1016/j.ijpsycho.2014.08.959 　

    ISSN： 0167-8760

    eISSN： 1872-7697

  146. Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) Peer-reviewed

    Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

    JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014/11

    DOI： 10.1111/jon.12076 　

    ISSN： 1051-2284

    eISSN： 1552-6569

  147. The neural basis of dishonest decisions that serve to harm or help the target Peer-reviewed

    Nobuhito Abe, Toshikatsu Fujii, Ayahito Ito, Aya Ueno, Yuta Koseki, Ryusaku Hashimoto, Akiko Hayashi, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    BRAIN AND COGNITION　90　41-49　2014/10

    DOI： 10.1016/j.bandc.2014.06.005 　

    ISSN： 0278-2626

    eISSN： 1090-2147

  148. Posterior cerebral artery involvement and pediatric moyamoya diseaslee Peer-reviewed

    Shunji Mugikura, Shoki Takahashi

    JOURNAL OF NEUROSURGERY-PEDIATRICS　14　(4)　434-435　2014/10

    DOI： 10.3171/2014.4.PEDS14185 　

    ISSN： 1933-0707

    eISSN： 1933-0715

  149. Diagnostic value of capsule-like rim enhancement on magnetic resonance imaging for distinguishing malignant from benign parotid tumours

    M. Sakamoto, M. Iikubo, I. Kojima, T. Sasano, S. Mugikura, T. Murata, M. Watanabe, K. Shiga, T. Ogawa, S. Takahashi

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY　43　(9)　1035-1041　2014/09

    DOI： 10.1016/j.ijom.2014.03.008 　

    ISSN： 0901-5027

    eISSN： 1399-0020

  150. Posterior circulation in moyamoya Peer-reviewed

    Shunji Mugikura, Shoki Takahashi

    JOURNAL OF NEUROSURGERY　120　(5)　1240-1240　2014/05

    DOI： 10.3171/2013.11.JNS132502 　

    ISSN： 0022-3085

    eISSN： 1933-0693

  151. Early CT Findings to Predict Early Death in Patients with Traumatic Brain Injury: Marshall and Rotterdam CT Scoring Systems Compared in the Major Academic Tertiary Care Hospital in Northeastern Japan Peer-reviewed

    Daddy Mata-Mbemba, Shunji Mugikura, Atsuhiro Nakagawa, Takaki Murata, Kiyoshi Ishii, Li Li, Kei Takase, Shigeki Kushimoto, Shoki Takahashi

    ACADEMIC RADIOLOGY　21　(5)　605-611　2014/05

    DOI： 10.1016/j.acra.2014.01.017 　

    ISSN： 1076-6332

    eISSN： 1878-4046

  152. Mechanisms of postoperative progression of steno-occlusive lesions in the posterior cerebral artery in moyamoya disease Peer-reviewed

    Shunji Mugikura, Shoki Takahashi

    CHILDS NERVOUS SYSTEM　30　(4)　557-558　2014/04

    DOI： 10.1007/s00381-014-2380-0 　

    ISSN： 0256-7040

    eISSN： 1433-0350

  153. Letter by Mugikura and Takahashi Regarding Article, "Perfusion Characteristics of Moyamoya Disease: An Anatomically and Clinically Oriented Analysis and Comparison"

    Shunji Mugikura, Shoki Takahashi

    STROKE　45　(3)　E48-E48　2014/03

    DOI： 10.1161/STROKEAHA.113.004348 　

    ISSN： 0039-2499

    eISSN： 1524-4628

  154. Dissociable neural systems for moral judgment of anti- and pro-social lying Peer-reviewed

    Akiko Hayashi, Nobuhito Abe, Toshikatsu Fujii, Ayahito Ito, Aya Ueno, Yuta Koseki, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    BRAIN RESEARCH　1556　46-56　2014/03

    DOI： 10.1016/j.brainres.2014.02.011 　

    ISSN： 0006-8993

    eISSN： 1872-6240

  155. Early response to chemotherapy as an indicator for the management of germinoma-like tumors of the pineal and/or suprasellar regions Peer-reviewed

    Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

    JOURNAL OF CLINICAL NEUROSCIENCE　21　(1)　124-130　2014/01

    DOI： 10.1016/j.jocn.2013.05.014 　

    ISSN： 0967-5868

    eISSN： 1532-2653

  156. Multiple thalamo-cortical disconnections in anterior thalamic infarction: Implications for thalamic mechanisms of memory and language Peer-reviewed

    Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Daisuke Ito, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    NEUROPSYCHOLOGIA　53　264-273　2014/01

    DOI： 10.1016/j.neuropsychologia.2013.11.025 　

    ISSN： 0028-3932

    eISSN： 1873-3514

  157. Developmental venous anomalies (DVAs) associated with hyperintense areas on T2-weighted images within the drainage territory

    Y. Kato, S. Mugikura, T. Murata, S. Takahashi, S. Higano

    Japanese Journal of Clinical Radiology　58　(10)　1325-1330　2013/10/01

    Publisher:

    ISSN： 0009-9252

  158. Detection of invasive components in cases of breast ductal carcinoma in situ on biopsy by using apparent diffusion coefficient MR parameters Peer-reviewed

    Naoko Mori, Hideki Ota, Shunji Mugikura, Chiaki Takasawa, Junya Tominaga, Takanori Ishida, Mika Watanabe, Kei Takase, Shoki Takahashi

    European Radiology　23　(10)　2705-2712　2013/10

    DOI： 10.1007/s00330-013-2902-2 　

    ISSN： 0938-7994 1432-1084

    eISSN： 1432-1084

  159. Medial posterior choroidal artery territory infarction associated with tumor removal in the pineal/tectum/thalamus region through the occipital transtentorial approach Peer-reviewed

    Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

    CLINICAL NEUROLOGY AND NEUROSURGERY　115　(8)　1257-1263　2013/08

    DOI： 10.1016/j.clineuro.2012.11.020 　

    ISSN： 0303-8467

  160. Encoding- and retrieval-related brain activity underlying false recognition Peer-reviewed

    Nobuhito Abe, Toshikatsu Fujii, Maki Suzuki, Aya Ueno, Yayoi Shigemune, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    Neuroscience Research　76　(4)　240-250　2013/08

    DOI： 10.1016/j.neures.2013.05.006 　

    ISSN： 0168-0102 1872-8111

  161. Infarction of the lateral posterior choroidal artery territory after manipulation of the choroid plexus at the atrium: causal association with subependymal artery injury. International-journal Peer-reviewed

    Ryuta Saito, Toshihiro Kumabe, Yukihiko Sonoda, Masayuki Kanamori, Shunji Mugikura, Shoki Takahashi, Teiji Tominaga

    Journal of neurosurgery　119　(1)　158-63　2013/07

    DOI： 10.3171/2013.2.JNS121221 　

    ISSN： 0022-3085

    More details Close

    OBJECT: The atrium of the lateral ventricle is often affected by tumors, and some patients with these tumors suffer neurological deficits, including hemiparesis after surgery. The authors of this study investigated the possible mechanisms causing the relatively high incidences of ischemic complications associated with surgery approaching the atrium of the lateral ventricle. METHODS: Clinical records and radiological images of 28 patients were retrospectively studied. These patients had their lateral ventricles opened at the atrium during the resection of gliomas as well as other nonbenign brain tumors, and were treated for gliomas at our tertiary referral center in the Tohoku district, Japan, between January 2008 and December 2010. RESULTS: Routine postoperative diffusion-weighted MR images obtained within 72 hours after surgery detected infarction in the periatrial/periventricular regions in 7 patients, presumably corresponding to the lateral posterior choroidal artery (LPChA) territory. Five of these 7 patients suffered neurological sequelae with varying severities. The choroid plexus at the atrium was coagulated to achieve hemostasis during the surgery in all of these patients. Detailed analysis of microangiograms revealed ventriculofugal arteries arising from the lateral ventricle. Damage of the subependymal artery that supplies the ventriculofugal arteries caused by coagulation of the choroid plexus at the atrium probably resulted in the infarction in these patients. CONCLUSIONS: Neurosurgeons must be aware of the possibility of LPChA territory infarction during surgery in the atrial or periatrial regions caused by subependymal artery obstruction after manipulating or coagulating the choroid plexus near the atrium.

  162. The contribution of the dorsolateral prefrontal cortex to the preparation for deception and truth-telling Peer-reviewed

    Ayahito Ito, Nobuhito Abe, Toshikatsu Fujii, Akiko Hayashi, Aya Ueno, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    BRAIN RESEARCH　1464　43-52　2012/06

    DOI： 10.1016/j.brainres.2012.05.004 　

    ISSN： 0006-8993

  163. Difficulty of the differential diagnosis of basal cell adenoma and basal cell adenocarcinoma of parotid gland by magnetic resonance imaging: case reports and literature review

    Ikuho Kojima, Maya Sakamoto, Mika Watanabe, Shoki Takahashi, Shunji Mugikura, Kiyoto Shiga, Masahiro Iikubo, Munemasa John Yamamura, Takashi Sasano

    ORAL RADIOLOGY　28　(1)　24-31　2012/03

    DOI： 10.1007/s11282-011-0076-7 　

    ISSN： 0911-6028

  164. Efficacy of Prophylactic Blood Pressure Lowering according to a Standardized Postoperative Management Protocol to Prevent Symptomatic Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease Peer-reviewed

    Miki Fujimura, Takashi Inoue, Hiroaki Shimizu, Atsushi Saito, Shunji Mugikura, Teiji Tominaga

    CEREBROVASCULAR DISEASES　33　(5)　436-445　2012

    DOI： 10.1159/000336765 　

    ISSN： 1015-9770

  165. Significance of Focal Cerebral Hyperperfusion as a Cause of Transient Neurologic Deterioration After Extracranial-Intracranial Bypass for Moyamoya Disease: Comparative Study With Non-Moyamoya Patients Using N-Isopropyl-p-[I-123]Iodoamphetamine Single-Photon Emission Computed Tomography Peer-reviewed

    Miki Fujimura, Hiroaki Shimizu, Takashi Inoue, Shunji Mugikura, Atsushi Saito, Teiji Tominaga

    NEUROSURGERY　68　(4)　957-964　2011/04

    DOI： 10.1227/NEU.0b013e318208f1da 　

    ISSN： 0148-396X

  166. The role of the dorsolateral prefrontal cortex in deception when remembering neutral and emotional events Peer-reviewed

    Ayahito Ito, Nobuhito Abe, Toshikatsu Fujii, Aya Ueno, Yuta Koseki, Ryusaku Hashimoto, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    NEUROSCIENCE RESEARCH　69　(2)　121-128　2011/02

    DOI： 10.1016/j.neures.2010.11.001 　

    ISSN： 0168-0102

    eISSN： 1872-8111

  167. Posterior Circulation and High Prevalence of Ischemic Stroke among Young Pediatric Patients with Moyamoya Disease: Evidence of Angiography-Based Differences by Age at Diagnosis

    S. Mugikura, S. Higano, R. Shirane, M. Fujimura, Y. Shimanuki, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　32　(1)　192-198　2011/01

    DOI： 10.3174/ajnr.A2216 　

    ISSN： 0195-6108

  168. Optimal treatment strategy for intracranial germ cell tumors

    Yukihiko Sonoda, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Syunji Mugikura, Teiji Tominaga

    Japanese Journal of Neurosurgery　20　(5)　372-378　2011

    Publisher: Japanese Congress of Neurological Surgeons

    DOI： 10.7887/jcns.20.372 　

    ISSN： 0917-950X

  169. Intracranial arterial system: The main trunks and major arteries of the cerebrum

    Shoki Takahashi, Shunji Mugikura

    Neurovascular Imaging: MRI and Microangiography　3-51　2011

    Publisher: Springer London

    DOI： 10.1007/978-1-84882-134-7_1 　

  170. Hippocampal activation associated with successful external source monitoring Peer-reviewed

    Shunji Mugikura, Nobuhito Abe, Maki Suzuki, Aya Ueno, Shuichi Higano, Shoki Takahashi, Toshikatsu Fujii

    NEUROPSYCHOLOGIA　48　(6)　1543-1550　2010/05

    DOI： 10.1016/j.neuropsychologia.2010.01.021 　

    ISSN： 0028-3932

  171. Unilateral moyamoya syndrome involving the ipsilateral anterior and posterior circulation associated with paroxysmal nocturnal hemoglobinuria Peer-reviewed

    Shunji Mugikura, Shuichi Higano, Miki Fujimura, Hiroaki Shimizu, Shoki Takahashi

    JAPANESE JOURNAL OF RADIOLOGY　28　(3)　243-246　2010/04

    DOI： 10.1007/s11604-009-0412-6 　

    ISSN： 1867-108X

  172. Unilateral moyamoya syndrome involving the ipsilateral anterior and posterior circulation associated with paroxysmal nocturnal hemoglobinuria Peer-reviewed

    Shunji Mugikura, Shuichi Higano, Miki Fujimura, Hiroaki Shimizu, Shoki Takahashi

    Japanese Journal of Radiology　28　(3)　243-246　2010/04

    DOI： 10.1007/s11604-009-0412-6 　

    ISSN： 1867-1071 1867-108X

    eISSN： 1867-108X

  173. Asymptomatic Moyamoya Disease Subsequently Manifesting as Transient Ischemic Attack, Intra cerebral Hemorrhage, and Subarachnoid Hemorrhage in a Short Period-Case Report Peer-reviewed

    Miki Fujimura, Shunji Mugikura, Hiroaki Shimizu, Teiji Tominaga

    NEUROLOGIA MEDICO-CHIRURGICA　50　(4)　316-319　2010/04

    DOI： 10.2176/nmc.50.316 　

    ISSN： 0470-8105

  174. Memory Repression: Brain Mechanisms underlying Dissociative Amnesia Peer-reviewed

    Hirokazu Kikuchi, Toshikatsu Fujii, Nobuhito Abe, Maki Suzuki, Masahito Takagi, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    JOURNAL OF COGNITIVE NEUROSCIENCE　22　(3)　602-613　2010/03

    DOI： 10.1162/jocn.2009.21212 　

    ISSN： 0898-929X

  175. Disruption of Thalamocortical Interconnections in Neurobehavioral Disturbance after Left Anterior Thalamic Infarction

    Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Daisuke Ito, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    ANNALS OF NEUROLOGY　68　(4)　S67-S68　2010

    ISSN： 0364-5134

  176. Relative Decrease in Signal Intensity of Subcortical White Matter in Spontaneous Intracranial Hypotension on Fluid-Attenuated Inversion Recovery Images

    M. Adachi, S. Mugikura, A. Shibata, E. Kawaguchi, T. Sato, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　30　(5)　906-910　2009/05

    DOI： 10.3174/ajnr.A1498 　

    ISSN： 0195-6108

  177. Usefulness of Contrast-Enhanced T1-Weighted Sampling Perfection with Application-Optimized Contrasts by Using Different Flip Angle Evolutions in Detection of Small Brain Metastasis at 3T MR Imaging: Comparison with Magnetization-Prepared Rapid Acquisition of Gradient Echo Imaging

    Y. Kato, S. Higano, H. Tamura, S. Mugikura, A. Umetsu, T. Murata, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　30　(5)　923-929　2009/05

    DOI： 10.3174/ajnr.A1506 　

    ISSN： 0195-6108

    eISSN： 1936-959X

  178. The Leptomeningeal "Ivy Sign" on Fluid-Attenuated Inversion Recovery MR Imaging in Moyamoya Disease: A Sign of Decreased Cerebral Vascular Reserve?

    N. Mori, S. Mugikura, S. Higano, T. Kaneta, M. Fujimura, A. Umetsu, T. Murata, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　30　(5)　930-935　2009/05

    DOI： 10.3174/ajnr.A1504 　

    ISSN： 0195-6108

  179. Incidence and risk factors for symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease Peer-reviewed

    Miki Fujimura, Shunji Mugikura, Tomohiro Kaneta, Hiroaki Shimizu, Teiji Tominaga

    SURGICAL NEUROLOGY　71　(4)　442-447　2009/04

    DOI： 10.1016/j.surneu.2008.02.031 　

    ISSN： 0090-3019

  180. Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: possible involvement of cerebral hyperperfusion and increased vascular permeability Peer-reviewed

    Miki Fujimura, Hiroaki Shimizu, Shunji Mugikura, Teiji Tominaga

    SURGICAL NEUROLOGY　71　(2)　223-227　2009/02

    DOI： 10.1016/j.surneu.2007.07.077 　

    ISSN： 0090-3019

  181. Temporal change of 3-T magnetic resonance imaging/angiography during symptomatic cerebral hyperperfusion following superficial temporal artery-middle cerebral artery anastomosis in a patient with adult-onset moyamoya disease Peer-reviewed

    Misaki Kohama, Miki Fujimura, Shunji Mugikura, Teiji Tominaga

    NEUROSURGICAL REVIEW　31　(4)　451-455　2008/10

    DOI： 10.1007/s10143-008-0147-3 　

    ISSN： 0344-5607

  182. Pseudo-subarachnoid hemorrhage found in patients with postresuscitation encephalopathy: Characteristics of CT findings and clinical importance

    H. Yuzawa, S. Higano, S. Mugikura, A. Umetsu, T. Murata, A. Nakagawa, A. Koyama, S. Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　29　(8)　1544-1549　2008/09

    DOI： 10.3174/ajnr.A1167 　

    ISSN： 0195-6108

  183. Progressive moyamoya syndrome associated with de novo formation of the ipsilateral venous and contralateral cavernous malformations: case report Peer-reviewed

    Elke Januschek, Miki Fujimura, Shunji Mugikura, Teiji Tominaga

    SURGICAL NEUROLOGY　69　(4)　423-427　2008/04

    DOI： 10.1016/j.sunreu.2007.01.078 　

    ISSN： 0090-3019

  184. Virtually Peeling Off the Skull and Scalp: A Simple Way of Mapping the Superficial Cerebral Veins on the Brain Surface

    X. Y. Gong, S. Higano, S. Mugikura, A. Umetsu, T. Murata, T. Kumabe, S. Takahashi

    STEREOTACTIC AND FUNCTIONAL NEUROSURGERY　86　(6)　345-350　2008

    DOI： 10.1159/000163555 　

    ISSN： 1011-6125

  185. Application of diffusion MR imaging to diagnosis of gliomas

    Shuichi Higano, S. Mugikura, A. Umezu, T. Murata, S. Takahashi, T. Kumabe

    Japanese Journal of Clinical Radiology　52　733-740　2007/07/06

    ISSN： 0009-9252

  186. Involvement of pterygoid venous plexus in patulous eustachian tube symptoms Peer-reviewed

    Takeshi Oshima, Masaki Ogura, Toshiaki Kikuchi, Yoko Hori, Shunji Mugikura, Shuichi Higano, Shoki Takahashi, Tetsuaki Kawase, Toshimitsu Kobayashi

    ACTA OTO-LARYNGOLOGICA　127　(7)　693-699　2007/07

    DOI： 10.1080/00016480600987818 　

    ISSN： 0001-6489

  187. Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease Peer-reviewed

    Miki Fujimura, Tomohiro Kaneta, Shunji Mugikura, Hiroaki Shimizu, Teiji Tominaga

    SURGICAL NEUROLOGY　67　(3)　273-282　2007/03

    DOI： 10.1016/j.surneu.2006.07.017 　

    ISSN： 0090-3019

  188. Malignant astrocytic tumors: Clinical importance of apparent diffusion coefficient in prediction of grade and prognosis Peer-reviewed

    Shuichi Higano, Xia Yun, Toshihiro Kumabe, Mika Watanabe, Shunji Mugikura, Atsushi Umetsu, Akihiro Sato, Takayuki Yamada, Shoki Takahashi

    RADIOLOGY　241　(3)　839-846　2006/12

    DOI： 10.1148/radiol.2413051276 　

    ISSN： 0033-8419

  189. Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease Peer-reviewed

    Miki Fujimura, Shunji Mugikura, Hiroaki Shimizu, Teiji Tominaga

    NEUROLOGICAL SURGERY　34　(8)　801-809　2006/08

    ISSN： 0301-2603

  190. Subcortical calcification on CT in dural arteriovenous fistula with cortical venous reflux

    T Metoki, S Mugikura, S Higano, M Ezura, Y Matsumoto, K Hirayama, S Takahashi

    AMERICAN JOURNAL OF NEURORADIOLOGY　27　(5)　1076-1078　2006/05

    ISSN： 0195-6108

  191. Changes in brain activation associated with use of a memory strategy: a functional MRI study Peer-reviewed

    Y Kondo, M Suzuki, S Mugikura, N Abe, S Takahashi, T Iijima, T Fujii

    NEUROIMAGE　24　(4)　1154-1163　2005/02

    DOI： 10.1016/j.neuroimage.2004.10.033 　

    ISSN： 1053-8119

  192. [Usefulness of MR diffusion imaging for evaluating brain tumors]. Peer-reviewed

    Higano S, Tamura H, Mugikura S, Umetsu A, Takahashi S

    Nihon Hoshasen Gijutsu Gakkai zasshi　60　(10)　1351-1360　2004/10

    ISSN： 0369-4305

  193. Diffusion-weighted MRI abnormalities as an early diagnostic marker for Creutzfeldt-Jakob disease

    Y Shiga, K Miyazawa, S Sato, R Fukushima, S Shibuya, Y Sato, H Konno, K Doh-ura, S Mugikura, H Tamura, S Higano, S Takahashi, Y Itoyama

    NEUROLOGY　63　(3)　443-449　2004/08

    DOI： 10.1212/01.WNL.0000134555.59460.5D 　

    ISSN： 0028-3878

  194. Neural basis of temporal context memory: A functional MRI study Peer-reviewed

    M Suzuki, T Fujii, T Tsukiura, J Okuda, A Umetsu, T Nagasaka, S Mugikura, Yanagawa, I, S Takahashi, A Yamadori

    NEUROIMAGE　17　(4)　1790-1796　2002/12

    DOI： 10.1006/nimg.2002.1303 　

    ISSN： 1053-8119

  195. Color-coded fractional anisotropy images: Differential visualization of white matter tracts

    T Murata, S Higano, S Takahashi, H Tamura, S Mugikura

    RADIOLOGY　225　430-430　2002/11

    ISSN： 0033-8419

  196. Brain activation during the fist-edge-palm test: A functional MRI study

    A Umetsu, J Okuda, T Fujii, T Tsukiura, T Nagasaka, Yanagawa, I, M Sugiura, K Inoue, R Kawashima, K Suzuki, M Tabuchi, T Murata, S Mugikura, S Higano, S Takahashi, H Fukuda, A Yamadori

    NEUROIMAGE　17　(1)　385-392　2002/09

    DOI： 10.1006/nimg.2002.1218 　

    ISSN： 1053-8119

  197. Conspicuity and evolution of lesions in Creutzfeldt-Jakob disease at diffusion-weighted imaging Peer-reviewed

    T Murata, Y Shiga, S Higano, S Takahashi, S Mugikura

    AMERICAN JOURNAL OF NEURORADIOLOGY　23　(7)　1164-1172　2002/08

    ISSN： 0195-6108

  198. Predominant involvement of ipsilateral anterior and posterior circulations in moyamoya disease Peer-reviewed

    S Mugikura, S Takahashi, S Higano, R Shirane, Y Sakurai, S Yamada

    STROKE　33　(6)　1497-1500　2002/06

    DOI： 10.1161/01.STR.0000016828.62708.21 　

    ISSN： 0039-2499

  199. Colour-coded fractional anisotropy images: Differential visualisation of white-matter tracts - Preliminary experience

    T. Murata, S. Higano, H. Tamura, S. Mugikura, S. Takahashi

    Neuroradiology　44　(10)　822-824　2002

    DOI： 10.1007/s00234-002-0868-x 　

    ISSN： 0028-3940

  200. Effectiveness of intra-arterial infusion chemotherapy for solitary bone metastasis from lung cancer with radiotherapy--a case report

    H. Terashima, S. Mugikura, S. Furuta, M. Saito, K. Hirayama

    Japanese Journal of Cancer and Chemotherapy　28　369-372　2001/03/01

    ISSN： 0385-0684

  201. The relationship between cerebral infarction and angiographic characteristics in childhood moyamoya disease

    Shunji Mugikura, Shoki Takahashi, Shuichi Higano, Reizo Shirane, Noriko Kurihara, Susumu Furuta, Masayuki Ezura, Akira Takahashi

    American Journal of Neuroradiology　20　(2)　336-343　1999

    ISSN： 0195-6108

  202. Comparison of ipsilateral activation between right and left handers: a functional MR imaging study

    LN Singh, S Higano, S Takahashi, N Kurihara, S Furuta, H Tamura, Y Shimanuki, S Mugikura, T Fujii, A Yamadori, M Sakamoto, S Yamada

    NEUROREPORT　9　(8)　1861-1866　1998/06

    DOI： 10.1097/00001756-199806010-00036 　

    ISSN： 0959-4965

  203. Hemorrhage in pituitary adenoma: correlation of MR imaging with operative findings

    N Kurihara, S Takahashi, S Higano, H Ikeda, S Mugikura, LN Singh, S Furuta, H Tamura, T Ishibashi, S Maruoka, S Yamada

    EUROPEAN RADIOLOGY　8　(6)　971-976　1998

    DOI： 10.1007/s003300050498 　

    ISSN： 0938-7994

  204. Correlation of lesions in the hippocampal region noted on MR images with clinical features

    S. Takahashi, S. Higano, N. Kurihara, S. Mugikura, K. Sakamoto, H. Nomura, H. Ikeda

    European Radiology　7　(2)　281-286　1997/01/01

    DOI： 10.1007/s003300050151 　

    ISSN： 0938-7994

  205. MR findings in Tay-Sachs disease

    S Mugikura, S Takahashi, S Higano, N Kurihara, K Kon, K Sakamoto

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY　20　(4)　551-555　1996/07

    DOI： 10.1097/00004728-199607000-00009 　

    ISSN： 0363-8715

Show all ︎Show first 5

Misc. 175

  1. 特発性正常圧水頭症患者における脳解剖画像の分離と標準化の精度向上を目的とした研究

    菅野重範, 川村藍, 劉軍艶, 永坂竜男, 麦倉俊司, 鈴木匡子

    Dementia Japan　38　(4)　2024

    ISSN： 1342-646X

  2. Relationship between MRI hippocampus volume and OCTA parameters

    高田菜生子, 橋本和軌, 二宮高洋, 前川重人, 石川誠, 國方彦志, 布施昇男, 麦倉俊司, 中澤徹

    日本眼科学会雑誌　128　2024

    ISSN： 0029-0203

  3. Letter to the Editor Regarding: “Identifying large vessel occlusion using the hyperdense artery sign in patients treated with mechanical thrombectomy”

    Shunji Mugikura, Naoko Mori

    Journal of Stroke and Cerebrovascular Diseases　32　(11)　2023/11

    DOI： 10.1016/j.jstrokecerebrovasdis.2023.107066 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  4. 無症候性の閉鎖性脊椎癒合不全のスクリーニングにおけるMRIの役割

    青木 英和, 麦倉 俊司, 白根 礼造, 林 俊哲, 君和田 友美, 坂井 清英, 相野谷 慶子, 大田 英揮, 高瀬 圭, 島貫 義久

    日本小児放射線学会雑誌　39　(Suppl.)　35-35　2023/05

    Publisher: (一社)日本小児放射線学会

    ISSN： 0918-8487

    eISSN： 2432-4388

  5. 心筋ストレスマーカーNT-proBNPと網膜表層血管密度との関連

    橋本 和軌, 國方 彦志, 高田 菜生子, 前川 重人, 二宮 高洋, Sharma Parmanand, 布施 昇男, 麦倉 俊司, 中澤 徹

    日本眼科学会雑誌　127　(臨増)　240-240　2023/03

    Publisher: (公財)日本眼科学会

    ISSN： 0029-0203

  6. 新規PET薬剤[18F]SMBT-1を用いたAD疾患連続体の進行予後予測に関する早期観察結果

    田代学, 田代学, 平岡宏太郎, 平岡宏太郎, 冨田尚希, 石木愛子, TEKEA Berihu, TEKEA Berihu, WU Yingying, 原田龍一, 菊地飛鳥, 菊地飛鳥, 武田和子, 草場美津江, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 渡部浩司, 麦倉俊司, 小林良太, 川勝忍, 石井賢二, 加藤隆司, 古本祥三, 古本祥三, 岡村信行, 岡村信行

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  7. 前頭側頭葉変性症における[18F]SMBT-1 PET所見

    小林良太, 川勝忍, 森岡大智, 平岡宏太良, 平岡宏太良, 冨田尚希, 四月朔日聖一, 四月朔日聖一, MESFIN Berihu, WU Yingying, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 渡部浩司, 麦倉俊司, 古川勝敏, 石井賢二, 加藤隆司, 原田龍一, 古本祥三, 古本祥三, 岡村信行, 岡村信行, 田代学, 田代学

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  8. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 2023

    田代学, 田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 小林良太, TEKEA Berihu, WU Yingying, 原田龍一, 菊地飛鳥, 菊地飛鳥, 武田和子, 草場美津江, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 渡部浩司, 麦倉俊司, 川勝忍, 石井賢二, 二橋尚志, 加藤隆司, 古本祥三, 古本祥三, 岡村信行, 岡村信行

    Dementia Japan　37　(4)　2023

    ISSN： 1342-646X

  9. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告2022

    田代 学, 平岡 宏太良, 冨田 尚希, 石木 愛子, 小林 良太, 四月朔日 聖一, メスフィン・ベリフ, 武田 和子, 草場 美津江, 菊池 昭夫, 渡部 浩司, 麦倉 俊司, 古川 勝敏, 加藤 隆司, 石井 賢二, 川勝 忍, 原田 龍一, 古本 祥三, 岡村 信行

    老年精神医学雑誌　33　(増刊II)　341-341　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  10. 扁桃体腫大を伴う側頭葉てんかん患者における発作時脳波所見の特徴

    此松 和俊, 神 一敬, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 麦倉 俊司, 青木 正志, 中里 信和

    てんかん研究　40　(2)　398-398　2022/08

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  11. 扁桃体腫大を伴う側頭葉てんかん患者における脳磁図所見の特徴

    此松 和俊, 神 一敬, 石田 誠, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 菅野 彰剛, 麦倉 俊司, 青木 正志, 中里 信和

    日本生体磁気学会誌　35　(1)　120-121　2022

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  12. 認知症疾患の層別化における[18F]SMBT-1の有用性の検討プロジェクトの経過報告 2022

    田代学, 田代学, 平岡宏太良, 平岡宏太良, 冨田尚希, 石木愛子, 石木愛子, 小林良太, 四月朔日聖一, 四月朔日聖一, メスフィン ベリフ, 武田和子, 草場美津江, 菊池昭夫, 渡部浩司, 渡部浩司, 麦倉俊司, 古川勝敏, 古川勝敏, 加藤隆司, 石井賢二, 川勝忍, 原田龍一, 古本祥三, 古本祥三, 岡村信行

    Dementia Japan　36　(4)　2022

    ISSN： 1342-646X

  13. 扁桃体腫大を伴う側頭葉てんかん患者における脳磁図所見の特徴

    此松 和俊, 神 一敬, 石田 誠, 佐藤 志帆, 森下 陽平, 曽我 天馬, 柿坂 庸介, 菅野 彰剛, 麦倉 俊司, 青木 正志, 中里 信和

    日本生体磁気学会誌　35　(1)　120-121　2022

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  14. Evaluation of Normalization Methods in a Cerebral Artery Atlas for Automatic Labeling

    Kazuyoshi Jin, Ko Kitamura, Shunji Mugikura, Naoko Mori, Makoto Ohta, Hitomi Anzai

    Volume 5: Biomedical and Biotechnology　2021/11/01

    Publisher: American Society of Mechanical Engineers

    DOI： 10.1115/imece2021-71097 　

    More details Close

    Abstract An existence probability atlas has been used for automatic labeling of cerebral arteries. However, the number of arteries varies frequently because of image quality and individual variation of the artery structure. To moderate the influence of number imbalance on labeling accuracy, we propose a new normalized atlas for automatic labeling of cerebral artery centerlines. The number of arteries, which was obtained from magnetic resonance angiography, varies from 11 to 46 among the artery sites. Based on the centerline and diameter, the arterial volume was reconstructed into a voxel space for each subject. After superimposing arteries from 46 subjects, three normalization methods were compared: dividing by the number of subjects (N), by N and the arterial length (L), and by N and the arterial volume (V). To compare the labeling accuracy and precision, the summation of probability and labeling method was also used. The accuracy of all normalization methods was &amp;gt; 85% in all arteries. The precision improved in some parts, with the atlas normalized by N-L and by N-V. The use of N-L and N-V changed the relative value of the existence probability among the parts. Consequently, some normalization methods changed the tendency toward misclassification, which changed the precision.

  15. Effective Quantitative Parameters of Vessel Wall Imaging in Distinguishing Unstable from Stable Intracranial Aneurysms

    MORI Naoko, MUGIKURA Shunji, ENDO Hidenori, SHIMIZU Hiroaki, HIGUCHI Kenichi, TAKAHASHI Shoki, TAKASE Kei

    日本医学放射線学会総会抄録集　80th　2021

    ISSN： 0048-0428

  16. 神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 抗MOG抗体関連疾患と抗AQP4陽性視神経脊髄炎の頭部MRI画像における病変分布の比較検討

    藤原一男, 松本勇貴, 三須建郎, 麦倉俊司, 高井良樹, 西山修平, 黒田宙, 高橋利幸, 藤盛寿一, 中島一郎, 青木正志

    神経免疫疾患のエビデンスに基づく診断基準・重症度分類・ガイドラインの妥当性と患者QOLの検証 令和2年度 総括・分担研究報告書(Web)　2021

  17. 3D time-of-flight MRAを用いた成人もやもや病に対する頭蓋外内バイパス術後過灌流症候群の予測

    西澤 威人, 藤村 幹, 勝木 将人, 田代 亮介, 佐藤 健一, 麦倉 俊司, 冨永 悌二

    脳循環代謝　32　(1)　112-112　2020/11

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  18. 抗MOG抗体及び抗AQP4抗体陽性疾患の頭部MRI画像における病変分布の比較検討

    松本 勇貴, 三須 建郎, 麦倉 俊司, 高井 良樹, 西山 修平, 黒田 宙, 高橋 利幸, 藤盛 寿一, 中島 一郎, 藤原 一男, 青木 正志

    神経免疫学　25　(1)　104-104　2020/10

    Publisher: 日本神経免疫学会

    ISSN： 0918-936X

  19. Quantitative analysis of high-resolution 3D-T2 weighted images for the diagnosis of lymph node metastasis of breast cancer

    SHIMIZU Hiroaki, MORI Naoko, TAKASAWA Chiaki, MUGIKURA Shunji, TAKASE Kei

    日本医学放射線学会総会抄録集　79th　2020

    ISSN： 0048-0428

  20. 軽症頭部外傷の睡眠障害 東北大学病院TBIクリニックの受傷から1年間の後方視的調査

    佐久間 篤, 八木橋 真央, 中川 敦寛, 麦倉 俊司, 内海 裕介, 古谷 桂子, 工藤 大介, 大沢 伸一郎, 久志本 成樹, 冨永 悌二, 富田 博秋

    総合病院精神医学　31　(Suppl.)　S-195　2019/11

    Publisher: (一社)日本総合病院精神医学会

    ISSN： 0915-5872

  21. 成人もやもや病に対するSTA-MCAバイパス術後の特異な脳循環動態 watershed shift現象の臨床像に関する検討

    田代 亮介, 藤村 幹, 亀山 昌幸, 麦倉 俊司, 遠藤 英徳, 新妻 邦泰, 冨永 悌二

    脳循環代謝　31　(1)　112-112　2019/11

    Publisher: (一社)日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  22. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例 Peer-reviewed

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 佐藤 志帆, 麦倉 俊司, 中里 信和

    臨床神経生理学　47　(5)　436-436　2019/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  23. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 佐藤 志帆, 麦倉 俊司, 中里 信和

    臨床神経生理学　47　(5)　436-436　2019/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  24. 頭部外傷受傷者に対する東北大学病院精神科リエゾンチームの取り組み

    佐久間 篤, 八木橋 真央, 中川 敦寛, 麦倉 俊司, 古谷 桂子, 工藤 大介, 大沢 伸一郎, 久志本 成樹, 冨永 悌二, 富田 博秋

    精神神経学雑誌　(2019特別号)　S764-S764　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  25. 【症候別画像診断プロトコル】疾病診断(症候別) 検査値・健診異常 ホルモン異常 下垂体[MRI]

    森下 陽平, 麦倉 俊司

    臨床画像　35　(4月増刊)　48-49　2019/04

    Publisher: (株)メジカルビュー社

    ISSN： 0911-1069

  26. 頭部外傷後の患者への精神科介入判断に関する考察 質と量的データの関連から

    八木橋 真央, 佐久間 篤, 中川 敦寛, 麦倉 俊司, 古谷 桂子, 工藤 大介, 大沢 伸一郎, 久志本 成樹, 冨永 悌二, 富田 博秋

    日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02

    Publisher: (一社)日本脳神経外傷学会

  27. 側頭葉てんかんにおける乳頭体萎縮の意義

    森下 陽平, 麦倉 俊司, 佐藤 志帆, 明石 敏昭, 高瀬 圭

    Japanese Journal of Radiology　37　(Suppl.)　8-8　2019/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  28. 脳神経外傷の画像診断 びまん性軸索損傷の診断に関する来院時CTの意義

    中川 敦寛, 麦倉 俊司, 今井 啓道, 八木橋 真央, 佐久間 篤, 大沢 伸一郎, 工藤 大介, 刈部 博, 近田 祐介, 冨田 博秋, 久志本 成樹, 冨永 悌二

    日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02

    Publisher: (一社)日本脳神経外傷学会

  29. 頭部外傷後の患者への精神科介入判断に関する考察 質と量的データの関連から

    八木橋 真央, 佐久間 篤, 中川 敦寛, 麦倉 俊司, 古谷 桂子, 工藤 大介, 大沢 伸一郎, 久志本 成樹, 冨永 悌二, 富田 博秋

    日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02

    Publisher: (一社)日本脳神経外傷学会

  30. 脳神経外傷の画像診断 びまん性軸索損傷の診断に関する来院時CTの意義

    中川 敦寛, 麦倉 俊司, 今井 啓道, 八木橋 真央, 佐久間 篤, 大沢 伸一郎, 工藤 大介, 刈部 博, 近田 祐介, 冨田 博秋, 久志本 成樹, 冨永 悌二

    日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02

    Publisher: (一社)日本脳神経外傷学会

  31. Normalization of Basilar Artery Structure with MRA Images

    北村洸, 麦倉俊司, 太田信, 安西眸

    日本機械学会バイオフロンティア講演会講演論文集(CD-ROM)　30th　2019

    ISSN： 1348-2939

  32. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

    菅野彰剛, 神一敬, 大沢伸一郎, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 佐藤志帆, 麦倉俊司, 中里信和, 中里信和

    臨床神経生理学(Web)　47　(5)　2019

    ISSN： 2188-031X

  33. 頭部外傷診療における救急医と脳神経外科医の役割 頭部外傷クリニック 脳振盪に対する対応の変化を踏まえた救急医と脳神経外科医の役割分担

    中川 敦寛, 富田 博秋, 佐久間 篤, 八木橋 真央, 麦倉 俊司, 大沢 伸一郎, 刈部 博, ジェフリー・マンレー, 久志本 成樹, 冨永 悌二

    日本救急医学会雑誌　29　(10)　330-330　2018/10

    Publisher: (一社)日本救急医学会

    ISSN： 0915-924X

    eISSN： 1883-3772

  34. 【押さえておきたい臨床・画像分類】 (第1章)脳脊髄 変性脱髄 多発性硬化症

    麦倉 俊司

    画像診断　38　(11)　A32-A37　2018/09

    Publisher: (株)学研メディカル秀潤社

    ISSN： 0285-0524

  35. 【てんかん診療-すべての医師のための診断・治療のコツ-】 てんかんの検査・診断 てんかんのMRI診断

    麦倉 俊司

    日本臨床　76　(6)　915-925　2018/06

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  36. 副鼻腔に進展したくも膜嚢胞の1例

    大山 翼, 村田 隆起, 麦倉 俊司, 北見 昌広, 明石 敏昭, 佐藤 志帆, 外山 由貴, Mata-Mbemba Daddy, 李 麗, 田村 元, 高橋 昭喜, 高瀬 圭

    Japanese Journal of Radiology　36　(Suppl.)　3-3　2018/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  37. 癌性髄膜炎との鑑別が困難であった静脈洞血栓症の1例

    村田 隆紀, 梅津 篤司, 麦倉 俊司, 北見 昌広, 明石 敏昭, 佐藤 志帆, 樋口 慧, 李 麗, 田村 元, 高橋 昭喜, 高瀬 圭

    Japanese Journal of Radiology　36　(Suppl.)　13-13　2018/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  38. もやもや病を究める もやもや病の脳循環研究 SPECTを用いた術後急性期病態の解明

    藤村 幹, 麦倉 俊司, 遠藤 英徳, 新妻 邦泰, 藤原 悟, 冨永 悌二

    脳循環代謝　29　(1)　144-144　2017/11

    Publisher: 日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  39. 頭蓋外内バイパス術後急性期に低灌流にもかかわらず症候性血管原性浮腫を生じた成人もやもや病の1例

    田代 亮介, 藤村 幹, 麦倉 俊司, 新妻 邦泰, 遠藤 英徳, 冨永 悌二

    脳循環代謝　29　(1)　193-193　2017/11

    Publisher: 日本脳循環代謝学会

    ISSN： 0915-9401

    eISSN： 2188-7519

  40. 様々な撮像法による神経疾患への新たなるアプローチ 臨床functional MRI&おさえておきたいマニアックな脳血管障害

    麦倉 俊司

    日本医学放射線学会秋季臨床大会抄録集　53回　S418-S418　2017/08

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  41. おさえておきたい脳血管障害と関連疾患

    麦倉 俊司

    Japanese Journal of Diagnostic Imaging　35　(1)　74-74　2017/02

    Publisher: 日本画像医学会

    ISSN： 2187-266X

  42. 基底核萎縮と尿崩症で発症したoccult germinomaの1例

    野村 脩子, 明石 敏昭, 麦倉 俊司, 佐藤 志帆, 舘脇 康子, 村田 隆紀, 加藤 裕美子, Mbemba Mata, 李 麗, 高瀬 圭

    Japanese Journal of Radiology　35　(Suppl.)　7-7　2017/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  43. 画像診断 今月の症例

    宮内 隼弥, 柿坂 庸介, 力石 健, 麦倉 俊司, 割田 仁, 小田切 邦雄

    小児科臨床　70　(1)　1-4　2017/01

    Publisher: (株)日本小児医事出版社

    ISSN： 0021-518X

  44. CONVECTION-ENHANCED DELIVERY OF NIMUSTINE HYDROCHLORIDE (ACNU) AGAINST PATIENTS WITH RECURRENT MALIGNANT GLIOMAS: ON-GOING CLINICAL TRIAL

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Jia Wenting, Takuhiro Shoji, Masashi Chonan, Shunji Mugikura, Takaki Murata, Toshihiro Kumabe, Teiji Tominaga

    NEURO-ONCOLOGY　18　10-11　2016/11

    ISSN： 1522-8517

    eISSN： 1523-5866

  45. 【Multi-Organ Disease-臓器からアプローチする全身疾患-】 脳神経 腫瘍性疾患

    麦倉 俊司

    臨床放射線　61　(11)　1319-1322　2016/11

    Publisher: 金原出版(株)

    DOI： 10.18888/J01565.2017052742 　

    ISSN： 0009-9252

  46. 【Multi-Organ Disease-臓器からアプローチする全身疾患-】 脳神経 内分泌疾患

    麦倉 俊司

    臨床放射線　61　(11)　1345-1348　2016/11

    Publisher: 金原出版(株)

    DOI： 10.18888/J01565.2017052747 　

    ISSN： 0009-9252

  47. 【脳腫瘍WHO2016-読影のための実践講座-】 脳室内およびその近傍の腫瘍

    麦倉 俊司, 金森 政之, 斉藤 竜太

    画像診断　36　(13)　1270-1282　2016/10

    Publisher: (株)学研メディカル秀潤社

    DOI： 10.15105/J00235.2017019943 　

    ISSN： 0285-0524

  48. 自作線量管理ソフトウェアを用いたCT検査における線量情報の収集とDRLs2015との比較

    田頭 豊, 志村 浩孝, 坂本 博, 佐藤 和宏, 梁川 功, 千田 浩一, 麦倉 俊司

    日本放射線技術学会雑誌　72　(9)　818-819　2016/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  49. 脳卒中発症後に原発性アルドステロン症の診断に至った症例の臨床的特徴の解明

    工藤 正孝, 森本 玲, 岩倉 芳倫, 小野 美澄, 祢津 昌広, 手塚 雄太, 五十嵐 康宏, 清治 和将, 麦倉 俊司, 高瀬 圭, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　39回　355-355　2016/09

    Publisher: (NPO)日本高血圧学会

  50. 【画像でみかける偶発的所見のマネジメント-あなたならどう書く?-】 脳神経 正常圧水頭症の所見がある場合

    佐藤 志帆, 麦倉 俊司

    画像診断　36　(9)　852-853　2016/07

    Publisher: (株)学研メディカル秀潤社

    DOI： 10.15105/J00235.2016356288 　

    ISSN： 0285-0524

  51. 【よくわかる中枢神経系血管炎】 血管と炎症の基礎 中枢神経系血管炎の画像診断

    麦倉 俊司

    Clinical Neuroscience　34　(5)　522-527　2016/05

    Publisher: (株)中外医学社

    ISSN： 0289-0585

  52. Transient global amnesia due to subcallosal artery infarct

    Michiko Kobayashi, Shun Yoshida, Aya Ishigaki, Juichi Fujimori, Yuko Meguro, Shunji Mugikura

    NEUROLOGY AND CLINICAL NEUROSCIENCE　4　(2)　81-+　2016/03

    DOI： 10.1111/ncn3.12049 　

    ISSN： 2049-4173

  53. 側頭葉てんかんの術前評価における海馬VolumetryとT2 Relaxometryの有用性

    佐藤 志帆, 麦倉 俊司, 舘脇 康子, 加藤 裕美子, 村田 隆紀, 高瀬 圭, 高橋 昭喜, 岩崎 真樹, 冨永 悌二, 神 一敬, 中里 信和, 鈴木 博義

    Japanese Journal of Radiology　34　(Suppl.)　11-11　2016/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  54. 低血糖脳症の予後とMRI所見の検討

    鈴木 美樹子, 加藤 裕美子, 舘脇 康子, 村田 隆紀, 麦倉 俊司, 高瀬 圭, 高橋 昭喜, 栗原 紀子

    Japanese Journal of Radiology　34　(Suppl.)　14-14　2016/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  55. 神経外傷とBiomedical Informatics 頭部外傷の現状 宮城県頭部外傷研究会2013年解析から

    中川 敦寛, 麦倉 俊司, 川口 奉洋, Matas Daddy, 古谷 桂子, 石ヶ森 朝香, 久志本 成樹, 冨永 悌二, 亀山 元信

    日本脳神経外傷学会プログラム・抄録集　39回　64-64　2016/02

    Publisher: (一社)日本脳神経外傷学会

  56. 重症びまん性軸索損傷のマーカーとしての初回CTにおける正中くも膜下出血(Traumatic midline subarachnoid hemorrhages on initial CT as markers of severe diffuse axonal injury)

    マタ・ムメンバ・ダディ, 麦倉 俊司, 中川 敦寛, 村田 隆紀, 石井 清, 久志本 成樹, 冨永 悌二, 高橋 昭喜, 高瀬 圭

    日本脳神経外傷学会プログラム・抄録集　39回　86-86　2016/02

    Publisher: (一社)日本脳神経外傷学会

  57. 部分容積効果補正法を用いたband heterotopia症例における異所性灰白質の血流・代謝評価の試み

    荒井 晃, 森下 陽平, 高浪 健太郎, 麦倉 俊司, 高瀬 圭, 瀧 靖之

    核医学　53　(1)　503-503　2016/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  58. 顔面多発骨折の急性期から慢性期までの至適治療:神経外傷医の観点から

    中川敦寛, 中川敦寛, 今井啓道, 麦倉俊司, 川口奉洋, 川口奉洋, 工藤大介, MATAS Daddy, 佐藤顕光, 館正弘, 久志本成樹, 冨永悌二

    日本形成外科学会総会・学術集会プログラム・抄録集　59th　196　2016

  59. Subcallosal artery梗塞 前交通動脈瘤治療後健忘症のMRI所見

    麦倉 俊司, 村田 隆紀, 高橋 昭喜, 菊池 大一, 藤井 俊勝, 森 悦郎, Marinkovic Slobodan

    東北脳血管障害研究会学術集会記録集　37回　5-31　2015/12

    Publisher: サノフィ(株)仙台オフィス

    ISSN： 1880-9278

  60. てんかん画像診断入門

    麦倉 俊司

    日本医学放射線学会秋季臨床大会抄録集　51回　S461-S461　2015/09

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  61. T2 Relaxometryによる海馬てんかん原性の評価

    岩崎 真樹, 佐藤 志帆, 麦倉 俊司, 大沢 伸一郎, 下田 由輝, 神 一敬, 高橋 昭喜, 中里 信和, 冨永 悌二

    てんかん研究　33　(2)　468-468　2015/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  62. 脳の病気 診断から治療まで 脳腫瘍の画像診断

    高橋 昭喜, 麦倉 俊司, 加藤 裕美子, 高浪 健太郎, 日向野 修一, 栗原 紀子

    日本放射線技術学会雑誌　71　(5)　468-480　2015/05

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  63. 頭蓋顔面骨折と外傷性脳損傷合併例の特徴

    中川 敦寛, 麦倉 俊司, Daddy Matas, 今井 啓道, 川口 奉洋, 工藤 大介, 古谷 桂子, 石ヶ森 朝香, 館 正弘, 久志本 成樹, 冨永 悌二

    日本脳神経外傷学会プログラム・抄録集　38回　100-100　2015/03

    Publisher: (一社)日本脳神経外傷学会

  64. 脳の病気 診断から治療まで 脳の病気 脳血管疾患における画像診断

    高橋 昭喜, 麦倉 俊司, 加藤 裕美子, 舘脇 康子, 日向野 修一, 栗原 紀子, 木下 俊文

    日本放射線技術学会雑誌　71　(2)　117-131　2015/02

    Publisher: (公社)日本放射線技術学会

    DOI： 10.6009/jjrt.2015_JSRT_71.2.117 　

    ISSN： 0369-4305

    eISSN： 1881-4883

  65. 頭蓋骨に発生した傍骨性骨肉腫の1例

    及川 朋美, 常陸 真, 長谷川 哲也, 館脇 康子, 李 麗, 麦倉 俊司, 高澤 千晶, 森 菜緒子, 松浦 智徳, 大田 英揮, 冨永 循哉, 負門 克典, 清治 和将, 田村 亮, 高瀬 圭, 高橋 昭喜, 遠藤 俊毅, 綿貫 宗則, 保坂 正美, 渡邊 みか

    Japanese Journal of Radiology　33　(Suppl.)　1-1　2015/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  66. 4D-MRAによるモヤモヤ病の血流評価

    村田 隆紀, 舘脇 康子, 麦倉 俊司, 李 麗, Mata Mbemba Daddy, 及川 朋美, 田村 元, 高橋 昭喜

    Japanese Journal of Radiology　33　(Suppl.)　8-8　2015/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  67. 片側巨脳症におけるdiffusion tensor imaging(DTI)の検討

    及川 朋美, 村田 隆紀, 舘脇 康子, Mata Daddy, 李 麗, 麦倉 俊司, 高橋 昭喜

    Japanese Journal of Radiology　33　(Suppl.)　9-9　2015/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  68. voxel based morphometry(VBM)を用いた緑内障における脳視路変性の検討

    舘脇 康子, 村田 隆紀, 麦倉 俊司, 高橋 昭喜, 瀧 靖之, 関口 敦, 面高 宗子, 中澤 徹

    Japanese Journal of Radiology　33　(Suppl.)　9-9　2015/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  69. 【頭部画像診断のpitfall:典型的所見の裏を読む】 聴神経鞘腫

    村田 隆紀, 麦倉 俊司

    臨床画像　30　(11)　1237-1245　2014/11

    Publisher: (株)メジカルビュー社

    ISSN： 0911-1069

  70. 【脳動脈瘤とくも膜下出血を究める】 嚢状動脈瘤破裂以外の原因によるくも膜下出血の画像診断

    麦倉 俊司

    画像診断　34　(13)　1449-1460　2014/10

    Publisher: (株)学研メディカル秀潤社

    DOI： 10.15105/J00235.2015043659 　

    ISSN： 0285-0524

  71. 原発性アルドステロン症における眼底血流評価の臨床的意義について

    工藤 正孝, 國方 彦志, 相澤 奈帆子, 麦倉 俊司, 新田 文彦, 小野 美澄, 岩倉 芳倫, 尾股 慧, 森本 玲, 清治 和将, 高瀬 圭, 高橋 秀肇, 中澤 徹, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　37回　368-368　2014/10

    Publisher: (NPO)日本高血圧学会

  72. 脳の病気 診断から治療まで 脳の病気 脳腫瘍

    高橋 昭喜, 麦倉 俊司, 日向野 修一, 栗原 紀子

    日本放射線技術学会雑誌　70　(9)　1095-1105　2014/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

  73. 【わずかな異常も見逃さない!救急での頭部画像の読み方 解剖をふまえた読影の手順からMRI適応の判断まで】 (第1章)総論 頭部画像診断の基本 脳血管解剖の基礎

    麦倉 俊司, 高橋 昭喜

    レジデントノート　16　(8)　1449-1460　2014/08

    Publisher: (株)羊土社

    ISSN： 1344-6746

  74. 脳の病気 診断から治療まで 脳の病気 脳血管障害

    高橋 昭喜, 麦倉 俊司, 日向野 修一

    日本放射線技術学会雑誌　70　(7)　721-728　2014/07

    Publisher: (公社)日本放射線技術学会

    DOI： 10.6009/jjrt.2014_JSRT_70.7.721 　

    ISSN： 0369-4305

  75. 転移性脳腫瘍の画像診断

    加藤 裕美子, 麦倉 俊司, 日向野 修一, 高橋 昭喜

    画像診断　34　(8)　946-960　2014/06

    Publisher: (株)学研メディカル秀潤社

    ISSN： 0285-0524

  76. 性差と加齢がもたらす他者の顔に対する価値表象に関わる神経基盤への影響 Peer-reviewed

    伊藤文人, 藤井俊勝, 阿部修士, 川崎伊織, 林亜希子, 上野彩, 吉田一生, 境信哉, 麦倉俊司, 高橋昭喜, 森悦朗

    第16回日本ヒト脳機能マッピング学会（仙台）　2014/03

  77. 頭部救急画像診断 miscellaneous

    麦倉 俊司

    Japanese Journal of Diagnostic Imaging　32　(1)　54-54　2014/02

    Publisher: 日本画像医学会

    ISSN： 2187-266X

  78. モヤモヤ病におけるMRAによる前方・後方循環病期分類

    麦倉 俊司, 村田 隆紀, 高橋 昭喜, 藤村 幹

    Japanese Journal of Radiology　32　(Suppl.)　8-8　2014/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  79. 緑内障患者における視神経・視放線の拡散テンソル解析の試み

    村田 隆紀, 佐藤 志帆, 舘脇 康子, 麦倉 俊司, 高橋 昭喜, 面高 宗子, 土井 洋, 中澤 徹, 大友 孝昭

    Japanese Journal of Radiology　32　(Suppl.)　9-9　2014/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  80. 頭蓋内胚細胞性腫瘍長期生存例のT2*強調像MRI所見 全脳照射vs全脳室照射

    李 麗, 麦倉 俊司, 村田 隆紀, 高橋 昭喜, 神宮 啓一, 隈部 俊宏, 藤井 俊勝, 森 悦郎

    Japanese Journal of Radiology　32　(Suppl.)　9-9　2014/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  81. Schmorl結節を合併した形質細胞腫の1例

    佐藤 志帆, 常陸 真, 麦倉 俊司, 高澤 千晶, 森 菜緒子, 松浦 智徳, 大田 英揮, 冨永 循哉, 清治 和将, 田村 亮, 高瀬 圭, 高橋 昭喜

    Japanese Journal of Radiology　32　(Suppl.)　15-15　2014/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  82. 低血糖脳症の重症度判定に関してMRI所見が有用であったと考えられた1症例

    岡村 将史, 麦倉 俊司, 坂本 拓矢, 千田 美穂, 奈古 一宏, 玉手 英一, 神宮 啓一, 小川 晋, 伊藤 貞嘉

    糖尿病　57　(2)　142-142　2014/02

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  83. 前頭蓋,前頭蓋底再建と外傷性脳損傷合併例の診断・治療:形成外科医の観点から

    今井啓道, 中川敦寛, 麦倉俊司, 工藤大介, MATAS Daddy, 佐藤顕光, 館正弘, 久志本成樹, 冨永悌二

    日本頭蓋顎顔面外科学会学術集会プログラム・抄録集　32nd　70-71　2014

  84. 前頭蓋,前頭蓋底再建と外傷性脳損傷合併例の診断,治療:神経外傷医の観点から

    中川敦寛, 今井啓道, 麦倉俊司, 工藤大介, MATAS Daddy, 佐藤顕光, 館正弘, 久志本成樹, 冨永悌二

    日本頭蓋顎顔面外科学会学術集会プログラム・抄録集　32nd　68-69　2014

  85. 無症状の小児における腰仙部皮膚異常所見と閉鎖性脊椎癒合不全症の相関

    青木英和, 島貫義久, 白根礼造, 林俊哲, 君和田友美, 坂井清英, 竹本淳, 高瀬圭, 麦倉俊司, 高橋昭喜

    日本神経放射線学会プログラム・抄録集　43rd　143　2014

  86. 【脳神経・頭頸部update 2013】 灌流域にT2強調像で高信号域を伴った静脈性奇形の検討

    加藤 裕美子, 麦倉 俊司, 村田 隆紀, 日向野 修一, 高橋 昭喜

    臨床放射線　58　(10)　1325-1330　2013/10

    Publisher: 金原出版(株)

    ISSN： 0009-9252

  87. 原発性アルドステロン症における非侵襲的眼血流測定法・レーザースペックルフローグラフィによる細動脈血管障害の評価

    工藤 正孝, 新田 文彦, 國方 彦志, 麦倉 俊司, 小野 美澄, 岩倉 芳倫, 松田 謙, 森本 玲, 相澤 奈帆子, 高橋 秀肇, 高橋 昭喜, 中澤 徹, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　36回　286-286　2013/10

    Publisher: (NPO)日本高血圧学会

  88. 辺縁系脳炎 ヘルペス・非ヘルペス

    麦倉 俊司

    日本医学放射線学会秋季臨床大会抄録集　49回　S487-S487　2013/09

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  89. 顔の魅力度に対する化粧品の使用と視線の影響 fMRIによる脳機能画像研究

    村上 優衣, 伊藤 文人, 川崎 伊織, 上野 彩, 河地 庸介, 麦倉 俊司, 松江 克彦, 境 信哉, 高橋 昭喜, 藤井 俊勝

    日本神経心理学会総会プログラム・予稿集　37回　153-153　2013/08

    Publisher: 日本神経心理学会

  90. Effects of cosmetics use and gaze direction on facial attractiveness: an fMRI study Peer-reviewed

    Yui Murakami, Ayahito Ito, Iori Kawasaki, Aya Ueno, Yosuke Kawachi, Shunji Mugikura, Yoshihiko Matsue, Shinya Sakai, Shoki Takahashi, Toshikatsu Fujii

    INS 2013 Mid-Year Meeting (Amsterdam)　2013/07

  91. Gender differences in the patterns of vmPFC activity associated with preference judgments for faces Peer-reviewed

    Ayahito Ito, Toshikatsu Fujii, Nobuhito Abe, Iori Kawasaki, Akiko Hayashi, Aya Ueno, Kazuki Yoshida, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

    INS 2013 Mid-Year Meeting (Amsterdam)　2013/07

  92. 【くも膜下出血-診断と治療のNew Standards】 くも膜下出血をおこすその他の疾患 細菌性脳動脈瘤

    新妻 邦泰, 清水 宏明, 麦倉 俊司, 冨永 悌二

    Clinical Neuroscience　31　(4)　421-423　2013/04

    Publisher: (株)中外医学社

    ISSN： 0289-0585

  93. 白質のびまん性腫脹を呈した間歇型CO中毒の1例

    青木 英和, 麦倉 俊司, 山本 貴也, 明石 敏昭, 舘脇 康子, 村田 隆紀, 高橋 昭喜, 黒田 宙

    Japanese Journal of Radiology　31　(Suppl.I)　5-5　2013/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  94. 造影3D-T1-FFE法による外側線条体動脈の術前評価

    明石 敏昭, 高橋 昭喜, 山本 貴也, 青木 英和, 舘脇 康子, 村田 隆紀, 麦倉 俊司, 隈部 俊宏

    Japanese Journal of Radiology　31　(Suppl.I)　5-5　2013/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  95. QUASAR-ASLにおける再現性、定量性の検討

    舘脇 康子, 日向野 修一, 村田 隆紀, 麦倉 俊司, 高橋 昭喜, 瀧 靖之

    Japanese Journal of Radiology　31　(Suppl.I)　5-5　2013/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  96. 拡散強調像高信号が診断に有用であった上矢状静脈洞血栓症の1例

    李 麗, 麦倉 俊司, 村田 隆紀, Daddy Mata Mbemba, 高橋 昭喜

    Japanese Journal of Radiology　31　(Suppl.I)　13-13　2013/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  97. 前交通動脈瘤破裂後健忘症のMR 3D-TSE T2強調像による検討

    麦倉 俊司, 村田 隆紀, 高橋 昭喜, 菊池 大一, 藤井 俊勝

    Japanese Journal of Radiology　31　(Suppl.I)　13-13　2013/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  98. 組織血液量がみかけの拡散係数(ADC)に与える影響

    根本 整, 豊田 誠, 永坂 竜男, 山中 一臣, 梁川 功, 田村 元, 麦倉 俊司

    日本放射線技術学会総会学術大会予稿集　69回　299-299　2013/02

    Publisher: (公社)日本放射線技術学会

    ISSN： 1884-7846

  99. 虚記憶の記銘と想起に関わる神経基盤

    阿部修士, 藤井俊勝, 鈴木麻希, 上野彩, 重宗弥生, 麦倉俊司, 高橋昭喜, 森悦朗

    日本ヒト脳機能マッピング学会プログラム・抄録集　15th　82　2013

  100. 他者の顔に対する価値表象に関わる神経基盤の性差 Peer-reviewed

    伊藤文人, 藤井俊勝, 阿部修士, 川崎伊織, 林亜希子, 上野彩, 吉田一生, 境 信哉, 麦倉俊司, 高橋昭喜, 森 悦朗

    第２回社会神経科学研究会（東岡崎）　2013/01

  101. CISS及びB-FFE撮影による前交通動脈穿通枝描出の試み

    稲葉 洋平, 永坂 竜男, 山中 一臣, 佐々木 博信, 千葉 陽子, 木村 智圭, 根本 整, 豊田 誠, 小川 千尋, 羽鳥 伸哉, 梁川 功, 麦倉 俊司

    日本放射線技術学会東北部会雑誌　(22)　104-105　2013/01

    Publisher: (公社)日本放射線技術学会-東北支部

  102. 原発性アルドステロン症における無症候性脳梗塞の合併を予測する新たなスコアの設定 CHA2DS2-VAScスコアとの比較検討

    工藤 正孝, 麦倉 俊司, 小野 美澄, 岩倉 芳倫, 松田 謙, 森本 玲, 高瀬 圭, 清治 和将, 高橋 昭喜, 伊藤 貞嘉, 佐藤 文俊

    日本高血圧学会総会プログラム・抄録集　35回　392-392　2012/09

    Publisher: (NPO)日本高血圧学会

  103. 頭部外傷受傷72時間以内における二次侵襲 転帰との関連とquality assurance

    中川 敦寛, 刈部 博, 古谷 桂子, 鷲尾 利克, 麦倉 俊司, 荒船 龍彦, Daddy Mata Mbemba, 宮村 奈美子, 工藤 大介, 久志本 成樹, 冨永 悌二

    Neurosurgical Emergency　17　(1)　67-71　2012/04

    Publisher: (NPO)日本脳神経外科救急学会

    ISSN： 1342-6214

  104. 診断に難渋した感染性脳塞栓症で発症した感染性心内膜炎の1例

    神野 恵子, 中川 敦寛, 麦倉 俊司, 野村 亮介, 古川 宗, 谷内 亜衣, 遠藤 智之, 入野 樹美, 久志本 成樹

    日本臨床救急医学会雑誌　15　(2)　325-325　2012/04

    Publisher: (一社)日本臨床救急医学会

    ISSN： 1345-0581

  105. 再発後14年を経過した副腎癌の一例

    菅原 明, 村上 治, 在原 善英, 鈴木 貴, 麦倉 俊司, 笹野 公伸, 伊藤 貞嘉

    ACTH RELATED PEPTIDES　23　29-31　2012/03

    Publisher: 間脳・下垂体・副腎系研究会

    ISSN： 1340-4512

  106. Cerebral proliferative angiopathyが疑われた一例

    青木 英和, 麦倉 俊司, 金田 朋洋, 佐谷 望, 荒井 晃, 高浪 健太郎, 高橋 昭喜

    核医学　49　(1)　32-33　2012/02

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  107. 亜急性の経過をたどった海綿静脈洞部腫瘍の1例

    三浦 永美子, 水野 秀紀, 佐藤 滋, 大沼 歩, 小川 欣一, 清水 宏明, 麦倉 俊司

    臨床神経学　52　(2)　120-120　2012/02

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  108. 皮質・皮質下病変を呈したosmotic myelinolysisの2症例

    舘脇 康子, 麦倉 俊司, 村田 隆紀, 加藤 裕美子, 高橋 昭喜

    Japanese Journal of Radiology　30　(Suppl.I)　1-1　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  109. 周囲にT2WI高信号域を伴った静脈性奇形の検討

    加藤 裕美子, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    Japanese Journal of Radiology　30　(Suppl.I)　1-1　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  110. GM1ガングリオシドーシスtype 3(成人発症型)の1例

    Daddy Mata, 村田 隆紀, 麦倉 俊司, 加藤 裕美子, 高橋 昭喜

    Japanese Journal of Radiology　30　(Suppl.I)　1-1　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  111. 灌流域にT2WI高信号を伴う静脈性奇形の検討(第2報) T2WI高信号を伴わない静脈性奇形との比較

    加藤 裕美子, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    Japanese Journal of Radiology　30　(Suppl.I)　8-8　2012/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  112. 灌流域にT2WI高信号を伴う静脈性奇形の検討 T2WI高信号を伴わない静脈性奇形との比較

    加藤 裕美子, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    日本医学放射線学会学術集会抄録集　70回　S286-S286　2011/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  113. 皮質・皮質下病変を呈したosmotic myelinolysisの一例

    舘脇 康子, 日向野 修一, 麦倉 俊司, 梅津 篤司, 加藤 裕美子, 高橋 昭喜, 栗原 紀子, 田邊 陽一郎

    Japanese Journal of Radiology　29　(Suppl.I)　4-4　2011/01

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  114. 感染性心内膜炎の頭部MRI所見

    阿部 恵子, 日向野 修一, 麦倉 俊司, 梅津 篤司, 加藤 裕美子, 高橋 昭喜

    Japanese Journal of Radiology　29　(Suppl.I)　7-7　2011/01

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  115. Optimal treatment strategy for intracranial germ cell tumors

    Yukihiko Sonoda, Toshihiro Kumabe, Ryuta Saito, Masayuki Kanamori, Yoji Yamashita, Syunji Mugikura, Teiji Tominaga

    Japanese Journal of Neurosurgery　20　(5)　372-378　2011

    Publisher: Japanese Congress of Neurological Surgeons

    DOI： 10.7887/jcns.20.372 　

    ISSN： 0917-950X

  116. 左視床前部梗塞における認知障害と視床-皮質回路離断

    西尾 慶之, 橋本 衛, 石井 一成, 伊藤 大輔, 麦倉 俊司, 高橋 昭喜, 森 悦朗

    臨床神経学　50　(12)　1150-1150　2010/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  117. 頭蓋内出血を伴ったPRES(posterior renersible encephalopathy syndrome)の2例

    高澤 千晶, 日向野 修一, 麦倉 俊司, 梅津 篤司, 村田 隆起, 加藤 裕美子, 金田 朋洋, 高橋 昭喜

    Japanese Journal of Radiology　28　(Suppl.I)　1-1　2010/07

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  118. 脳転移検出における造影SPACE(3D-fast spin echo)法の有用性

    加藤 裕美子, 日向野 修一, 麦倉 俊司, 梅津 篤司, 村田 隆紀, 高橋 昭喜

    Japanese Journal of Radiology　28　(Suppl.I)　1-1　2010/07

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  119. 3テスラMRI装置を用いたarterial spin labeling法によるregional perfusion imagingの初期経験 脳血管障害を中心に

    村田 隆紀, 日向野 修一, 麦倉 俊司, 梅津 篤司, 高橋 昭喜, 鈴木 由里子

    Japanese Journal of Radiology　28　(Suppl.I)　2-2　2010/07

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  120. Crowned dens syndromeの画像所見

    松本 世津, 日向野 修一, 加藤 裕美子, 村田 隆紀, 梅津 篤司, 麦倉 俊司, 高橋 昭喜

    Japanese Journal of Radiology　28　(Suppl.I)　11-11　2010/07

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  121. 左上側頭回から下頭頂小葉病変例の語音認知、音韻把持、音韻操作能力の検討

    遠藤 佳子, 飯塚 統, 西尾 慶之, 平山 和美, 橋本 竜作, 藤井 俊勝, 森 悦朗, 麦倉 俊司, 松村 邦也, 及川 尚美

    高次脳機能研究　30　(1)　104-104　2010/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

  122. 【CT・MRIアトラス Update 正常解剖と読影のポイント】 脳 大脳皮質

    日向野 修一, 麦倉 俊司, 梅津 篤司, 加藤 裕美子, 高橋 昭喜

    Medicina　46　(12)　73-81　2009/11

    Publisher: (株)医学書院

    ISSN： 0025-7699

  123. もやもや病に対するEC-IC bypass術後急性期3D-TOF MRAを用いた症候性過灌流の診断と予測についての検討

    藤村 幹, 麦倉 俊司, 新妻 邦泰, 清水 宏明, 冨永 悌二

    脳循環代謝　21　(1)　138-138　2009/11

    Publisher: 日本脳循環代謝学会

    ISSN： 0915-9401

  124. 3T時代の造影MRI その適応と限界 1.5Tとの比較も含めて 頭頸部 頭部におけるperfusion MRI

    日向野 修一, 伊藤 大輔, 村田 隆紀, 鈴木 由里子, 麦倉 俊司, 梅津 篤司, 加藤 裕美子, 高橋 昭喜

    INNERVISION　24　(5)　89-96　2009/04

    Publisher: (株)インナービジョン

    ISSN： 0913-8919

  125. 蘇生後脳CTのPseudo-SAH所見 CT値と予後の検当

    湯澤 寛尚, 日向野 修一, 麦倉 俊司, 梅津 篤志, 村田 隆紀, 高橋 昭喜, 中川 敦寛, 小山 敦

    Japanese Journal of Radiology　27　(Suppl.)　4-4　2009/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  126. 造影SPACE(3D-fast spin echo)法が有用だった脳転移の1例

    加藤 裕美子, 日向野 修一, 麦倉 俊司, 梅津 篤司, 村田 隆紀, 高橋 昭喜

    Japanese Journal of Radiology　27　(Suppl.)　10-10　2009/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  127. colloid cystの2例

    李 麗, 麦倉 俊司, 日向野 修一, 梅津 篤司, 村田 隆紀, 高橋 昭喜, 藤村 幹, 冨永 悌二

    Japanese Journal of Radiology　27　(Suppl.)　15-15　2009/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

  128. Medullary streaksを観察し得た急性期脳梗塞の一例

    中川 敦寛, 藤村 幹, 冨永 悌二, 麦倉 俊司, 黒田 宙, 野村 亮介, 篠澤 洋太郎

    東北脳血管障害研究会学術集会記録集　30回　57-60　2008/12

    Publisher: サノフィ(株)仙台オフィス

    ISSN： 1880-9278

  129. 3T MRにおける脳の灌流画像

    日向野 修一, 村田 隆紀, 伊藤 大輔, 鈴木 由里子, 麦倉 俊司, 梅津 篤司, 高橋 昭喜

    日本磁気共鳴医学会雑誌　28　(4)　289-302　2008/10

    Publisher: (一社)日本磁気共鳴医学会

    ISSN： 0914-9457

  130. 【evidence-based radiology】 中枢神経

    梅津 篤司, 麦倉 俊司, 日向野 修一, 高橋 昭喜

    臨床画像　24　(6)　748-760　2008/06

    Publisher: (株)メジカルビュー社

    ISSN： 0911-1069

  131. colloid cystの二例

    李 麗, 麦倉 俊司, 日向野 修一, 梅津 篤司, 村田 隆紀, 高橋 昭喜, 藤村 幹, 冨永 悌二

    核医学　45　(2)　143-143　2008/05

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  132. モヤモヤ病におけるleptomeningeal ivy signの臨床的意義

    森 菜緒子, 麦倉 俊司, 日向野 修一, 梅津 篤司, 高橋 昭喜, 藤村 幹

    Radiation Medicine　26　(Suppl.I)　9-9　2008/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  133. Remote Cerebellar Hemorrhage 当院での4例

    梅津 篤司, 麦倉 俊司, 日向野 修一, 高橋 昭喜

    Radiation Medicine　26　(Suppl.I)　9-9　2008/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  134. もやもや病に対する直接血行再建術後急性期の病態について 3-Tesla MRIを用いた検討

    小濱 みさき, 藤村 幹, 麦倉 俊司, 冨永 悌二

    日本脳神経外科学会総会CD-ROM抄録集　66回　3K-P55　2007/10

    Publisher: (一社)日本脳神経外科学会

    ISSN： 1347-9040

  135. 【脳腫瘍の診断と治療 グリオーマにおける画像診断の役割を中心に】 グリオーマの診断における拡散強調像の利用

    日向野 修一, 隈部 俊宏, 麦倉 俊司, 梅津 篤司, 村田 隆紀, 高橋 昭喜

    臨床放射線　52　(6)　733-740　2007/06

    Publisher: 金原出版(株)

    ISSN： 0009-9252

  136. Refresher Course 脳MRI読影のピットフォール 病変と紛らわしい正常構造・変異

    日向野 修一, 麦倉 俊司, 梅津 篤司, 村田 隆紀, 高橋 昭喜

    画像診断　27　(5)　629-640　2007/04

    Publisher: (株)学研メディカル秀潤社

    ISSN： 0285-0524

  137. 皮質下に特徴的石灰化を呈した脳硬膜動静脈瘻の3例

    目時 隆博, 麦倉 俊司, 梅津 篤司, 日向野 修一, 高橋 昭喜, 江面 正幸, 平山 和美

    Radiation Medicine　25　(Suppl.I)　9-9　2007/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  138. MRIによる耳管とその周囲構造の描出の試み

    湯澤 寛尚, 高橋 昭喜, 日向野 修一, 麦倉 俊司, 梅津 篤司, 小林 俊光, 大島 猛史, 小倉 正樹

    Radiation Medicine　25　(Suppl.I)　15-15　2007/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  139. MRIによる低位穹窿レベル中心溝の同定法

    目時 隆博, 麦倉 俊司, 梅津 篤志, 日向野 修一, 高橋 昭喜

    Radiation Medicine　25　(Suppl.I)　19-19　2007/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  140. 潰瘍性大腸炎に合併した頭蓋内出血の2例

    梅津 篤司, 麦倉 俊司, 日向野 修一, 高橋 昭喜

    Radiation Medicine　25　(Suppl.I)　20-20　2007/04

    Publisher: (公社)日本医学放射線学会

    ISSN： 0288-2043

  141. もやもや病に対する血行再建術後急性期の臨床像と脳循環動態 脳灌流MRIを用いた検討

    藤村 幹, 麦倉 俊司, 清水 宏明, 冨永 悌二

    Neurological Surgery　34　(8)　801-809　2006/08

    Publisher: (株)医学書院

    ISSN： 0301-2603

  142. T2強調像で低信号を呈した多形腺腫の1例

    阪本 真弥, 日向野 修一, 渡辺 みか, 麦倉 俊司, 梅津 篤司, 高橋 昭喜, 志賀 清人, 笹野 高嗣

    歯科放射線　46　(2)　60-61　2006/06

    Publisher: (NPO)日本歯科放射線学会

    DOI： 10.11242/dentalradiology.46.60 　

    ISSN： 0389-9705

    eISSN： 2185-6311

  143. 【RSNA2005】 脳MR画像における臨床的意義に乏しい病変とアーチファクトによる偽病変 正常か異常か?

    日向野 修一, 麦倉 俊司, 梅津 篤司, 高橋 昭喜

    INNERVISION　21　(3)　71-71　2006/02

    Publisher: (株)インナービジョン

    ISSN： 0913-8919

  144. 低位穹隆部の中心溝同定法

    目時 隆博, 麦倉 俊司, 梅津 篤司, 日向野 修一, 高橋 昭喜

    日本医学放射線学会学術集会抄録集　65回　S249-S249　2006/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  145. モヤモヤ病に対する血行再建術前後の脳循環と臨床像:SPECT・PWIと術中赤外線画像装置による検討

    藤村幹, 麦倉俊司, 金田朋洋, 中川敦寛, 清水宏明, 冨永悌二

    日本脳神経外科学会総会抄録集(CD-ROM)　65th　2006

    ISSN： 1347-9040

  146. Sites of intracranial hemorrhage in adult Moyamoya disease and associated angiographic findings

    S Mugikura, S Higano, Y Kusaka, R Shirane, S Takahashi

    STROKE　36　(2)　443-443　2005/02

    ISSN： 0039-2499

  147. 悪性グリオーマのグレーディング予測のためのMRパラメータに関する研究(1)

    雲 霞, 日向野 修一, 隈部 俊宏, 渡辺 みか, 麦倉 俊司, 田村 元, 高橋 明, 高橋 昭喜

    日本医学放射線学会学術集会抄録集　64回　S200-S200　2005/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  148. CJD診断における拡散強調MRIの必要性

    志賀 裕正, 麦倉 俊司, 田村 元, 糸山 泰人

    臨床神経学　44　(12)　1192-1192　2004/12

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

  149. 脳MR灌流画像における動脈通過時間の測定

    田村 元, 麦倉 俊司, 日向野 修一, 高橋 昭喜

    日本医学放射線学会雑誌　64　(8)　577-577　2004/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  150. 第4脳室のMRI 第4脳室および周囲構造同定の試み

    高橋 昭喜, 日向野 修一, 田村 元, 麦倉 俊司, 湯澤 寛尚, 隈部 俊宏, 栗原 紀子

    日本医学放射線学会雑誌　64　(8)　578-578　2004/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  151. 拡散画像って脳腫瘍にも役に立つの?

    日向野 修一, 田村 元, 麦倉 俊司, 梅津 篤司, 高橋 昭喜

    日本放射線技術学会雑誌　60　(10)　1351-1360　2004/10

    Publisher: (公社)日本放射線技術学会

    DOI： 10.6009/jjrt.KJ00003326534 　

    ISSN： 0369-4305

  152. 【マルチスライスCTとMRIの臨床応用】 頭部・頭頸部 脳腫瘍

    日向野 修一, 田村 元, 麦倉 俊司, 高橋 昭喜

    診断と治療　92　(9)　1511-1523　2004/09

    Publisher: (株)診断と治療社

    ISSN： 0370-999X

  153. 脳拡散テンソルデータに基づくfiber trackingの試み

    田村 元, 日向野 修一, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    日本医学放射線学会雑誌　63　(9)　596-596　2003/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  154. 脳の拡散テンソル画像(DTI)のStatistical parametric mapping(SPM)による標準化の試み

    日向野 修一, 田村 元, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    日本医学放射線学会雑誌　63　(9)　596-596　2003/11

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  155. 磁気共鳴画像(MRI)による脳機能画像の解剖学的標準化の研究

    日向野 修一, 高橋 昭喜, 田村 元, 麦倉 俊司

    INNERVISION　18　(8)　44-44　2003/07

    Publisher: (株)インナービジョン

    ISSN： 0913-8919

  156. Statistical parametric mapping(SPM)を用いた脳拡散テンソル画像(DTI)の標準化の精度の検討

    日向野 修一, 麦倉 俊司, 田村 元, 村田 隆紀, 高橋 昭喜

    日本医学放射線学会雑誌　63　(2)　S159-S159　2003/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  157. Redundant Nerve Roots MRI所見を中心に

    壺井 匡浩, 日向野 修一, 田村 元, 麦倉 俊司, 松橋 俊夫, 山田 隆之, 佐藤 明弘, 齋藤 春夫, 石橋 忠司, 高橋 昭喜

    日本医学放射線学会雑誌　62　(12)　708-708　2002/10

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  158. ADEMとの鑑別に苦慮したintrarvascular lymphomatosisの1例

    嶋内 亜希子, 村田 隆紀, 麦倉 俊司, 田村 元, 日向野 修一, 高橋 昭喜, 志賀 裕正, 渡辺 みか

    日本医学放射線学会雑誌　62　(12)　708-708　2002/10

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  159. 先天性サイトメガロウィルス感染の白質変化:脳MRI

    菅原 俊幸, 梅津 篤司, 日向野 修一, 田村 元, 麦倉 俊司, 村田 隆紀, 高橋 昭喜

    日本医学放射線学会雑誌　62　(6)　297-297　2002/05

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  160. 小児モヤモヤ病のPosterior CirculationとIschemic Stroke

    麦倉 俊司, 高橋 昭喜, 日向野 修一, 田村 元, 村田 隆紀, 白根 礼造, 櫻井 芳明, 栗原 紀子

    日本医学放射線学会雑誌　62　(6)　298-298　2002/05

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  161. カラーコード化FA画像 白質路の鑑別(Color-coded FA Images: Differential Visualization of White Matter Tracts)

    村田 隆紀, 日向野 修一, 高橋 昭喜, 田村 元, 麦倉 俊司

    日本医学放射線学会雑誌　62　(3)　S289-S289　2002/03

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  162. Idiopathic colonic varicesより大量下部消化管出血をきたした1例

    古田 進, 金田 朋洋, 麦倉 俊司, 齋藤 昌宏, 清水 拓也, 寺島 秀夫, 櫻井 直, 平山 克, 嵯峨 知生, 高橋 廣己

    日本医学放射線学会雑誌　62　(1)　43-43　2002/01

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

    eISSN： 1347-7951

  163. 成人もやもや病の血管撮影所見 出血発症と虚血発症の相違点

    麦倉 俊司, 高橋 昭喜, 日向野 修一, 村田 隆紀, 梅津 篤司, 白根 礼造, 櫻井 芳明

    日本医学放射線学会雑誌　62　(1)　38-38　2002/01

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  164. 内頸動脈ステント留置後のHyperperfusion SPECT&CT所見

    麦倉 俊司, 古田 進, 伏見 進, 米谷 元裕, 高橋 昭喜, 伊藤 浩

    核医学　38　(2)　172-173　2001/03

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

  165. 腸管出血性大腸菌O157感染症による出血性大腸炎のCT所見の検討

    古田 進, 麦倉 俊司, 堀川 洋平, 下田 泉, 高橋 廣巳, 大久保 俊治

    日本医学放射線学会雑誌　61　(4)　183-183　2001/03

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  166. 肺癌術後の孤立性骨転移巣に対して放射線併用動注化学療法が著効を奏した1例

    寺島 秀夫, 麦倉 俊司, 古田 進, 斉藤 昌宏, 平山 克

    癌と化学療法　28　(3)　369-372　2001/03

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  167. CT検査時,ヨード造影投与直後に起こるアレルギー反応及び遅発性副作用の実態 看護の安全性の再点検

    菅原 恵美子, 齊藤 昌宏, 麦倉 俊司, 古田 進, 間島 一浩

    秋田県農村医学会雑誌　46　(1)　57-57　2000/07

    Publisher: (一財)秋田県農村医学会

    ISSN： 0002-368X

  168. 下肢動脈angiographyにおけるstepping DSAの評価

    柴田 信雄, 佐藤 義晴, 佐藤 親生, 高橋 茂, 工藤 裕三, 麦倉 俊司, 間島 一浩

    秋田県農村医学会雑誌　45　(2)　80-80　2000/02

    Publisher: (一財)秋田県農村医学会

    ISSN： 0002-368X

  169. 当院の頭部3D-CTAの検討とその有用性

    田中 義春, 間島 一浩, 麦倉 俊司, 伊藤 幸男

    秋田県農村医学会雑誌　45　(2)　79-80　2000/02

    Publisher: (一財)秋田県農村医学会

    ISSN： 0002-368X

  170. 画像所見と病理学的所見の対比が可能であった狭窄型虚血性腸炎の2例

    間島 一浩, 麦倉 俊司, 斎藤 昌広, 力丸 裕哉, 寺島 秀夫, 島田 友幸

    日本医学放射線学会雑誌　59　(6)　271-271　1999/05

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  171. 糖原病の肝CT所見

    山田 隆之, 田村 亮, 齋藤 春夫, 石橋 忠司, 麦倉 俊司, 高橋 昭喜, 山田 章吾

    日本医学放射線学会雑誌　59　(6)　268-268　1999/05

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  172. 成人発症もやもや病のCT/MR所見

    麦倉 俊司, 間島 一浩, 高橋 昭喜, 古田 進, 白根 礼造, 高橋 明, 江面 正幸

    日本医学放射線学会雑誌　59　(6)　277-277　1999/05

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  173. 糖原病の肝臓CT所見

    山田 隆之, 齋藤 春夫, 石橋 忠司, 田村 亮, 麦倉 俊司, 高橋 昭喜, 山田 章吾

    日本医学放射線学会雑誌　59　(2)　S253-S253　1999/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  174. 成人発症もやもや病の検討

    麦倉 俊司

    日本医学放射線学会雑誌　58　(7)　380-380　1998/06

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

  175. 小児期発症もやもや病の後方循環と脳梗塞

    麦倉 俊司

    日本医学放射線学会雑誌　57　(2)　S41-S41　1997/02

    Publisher: (公社)日本医学放射線学会

    ISSN： 0048-0428

Show all ︎Show first 5

Research Projects 35

  1. 非対面・反復可能論理的記憶と定量MRIによる住民コホート超早期認知症発見プログラム

    麦倉 俊司, 伊藤 文人, 森 菜緒子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2024/04/01 - 2027/03/31

  2. International research using big data for lifestyle disease, brain aging and genetic background

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. 人工知能を用いたもやもや病における病期進行予測モデルの開発

    遠藤 英徳, 中川 敦寛, 新妻 邦泰, 麦倉 俊司, 杉山 慎一郎, 園部 真也, 植田 琢也, 面高 俊介

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

  4. Establishment of a prediction model for aneurysm development by mathematical vascular branching pattern classification and vascular travel standardisation.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  5. Development of radioprotective agent for the central nervous system

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  6. 脳形態画像に基づく3次元血流場推定ネットワークの開発

    安西 眸, 麦倉 俊司, 杉山 慎一郎, 森 菜緒子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  7. A proposal for "anti-dementia dietary habits" based on healthy longevity epigenomics that links dietary habits and cognitive function

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: University of Yamanashi

    2021/04/01 - 2024/03/31

  8. Establishment of ultra-early pancreatic cancer detection algorithm by preclinical pancreatic cancer matching cohort

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  9. Construction of higher-order dysfunction diagnosis system after anterior communicating artery aneurysm by non-contrast perfusion MRI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  10. Visualization of stroke risk using standard model of MRA vascular course and wall stress

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  11. シロスタゾールを用いたもやもや病における内因性幹細胞賦活と血管新生促進療法の開発

    藤村 幹, 冨永 悌二, 新妻 邦泰, 麦倉 俊司, 坂田 洋之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    2020/04/01 - 2023/03/31

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    もやもや病は異常血管網発達ならびに代償的な側副血行路を含めた血管新生能を有する原因不明の疾患である。小児や若年成人に好発し、浅側頭動脈・中大脳動脈吻合術（直接血行再建術）や側頭筋を用いた間接血行再建術を含めた外科治療の有効性が確立しているが、重症例に対する治療は未確立である。間接術は脳損傷を伴う重症例にも安全に行うことが可能であるが、間接術単独の場合は血管新生不良例が見られる点が問題である。血管新生能を高める試みがなされているがその効果は限定的であるのが現状である。今回、内因性多能性幹細胞とその活性化に期待が持てる薬剤に着目し、間接術からの血管新生の機序を解明し、その効果を促進する手法を開発することによりもやもや病の治療成績の向上が期待できると着想した。本研究の目的は、もやもや病患者クモ膜における内因性多能性幹細胞の発現と血行再建術後の血管新生の関連を明らかにし、「もやもや病に対するシロスタゾールを用いた内因性多能性幹細胞の賦活と血行再建術効果促進」の概念実証し、臨床レベルでもやもや病手術例に対するシロスタゾールを用いた内因性多能性幹細胞の賦活による血行再建術効果療法を確立することである。 ２年度目は、血行再建術を行ったもやもや病患者に由来する検体を用いて、患者クモ膜組織における内因性多能性幹細胞を免疫組織学的に検討した。18例の患者より得られたクモ膜について、多能性幹細胞の複数の指標について免疫組織染色を行ったところ多くの検体において多能性幹細胞マーカー陽性所見を認めた。また術後MRAを行い血管新生の程度と術前脳虚血、RNF213遺伝子異常との関連を検証し有意な結果を得た。もやもや病患者クモ膜において内因性多能性幹細胞が存在すること、RNF213遺伝子変異により血管新生が増幅されることが示唆された。

  12. Analysis of latent imaging findings in healthy subjects with moyamoya disease susceptibility gene RNF213 polymorphism using artificial intelligence

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  13. Development of imaging diagnosis support system for emergency patients by artificial intelligence

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2023/03/31

  14. Higher brain dysfunction after traffic accidents: Establishment of a certified support system by Advanced MR.

    Takahashi Shoki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    Higher brain dysfunction following a traffic accident is caused by extensive damage to axons (nerve fibers) (diffuse axonal damage) due to a strong impact. Physical findings are poor and may not be noticed until the chronic phase. Conventional MRI can be used to diagnose diffuse axonal injury in the acute phase, but the detection rate is low in the chronic phase, and effective imaging methods have not been established. In the present study, we examined the possibility of using advanced MRI to diagnose higher brain dysfunction.

  15. metabolome analysis focusing on the malignant transformation of astrocytoma

    Masayuki Kanamori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    We searched for useful metabolites for (1) malignant transformation of astrocytoma and (2) intraoperative differentiation of astrocytoma and oligodendroglioma. Metabolome analysis was performed on the frozen tissue using an ion trap type mass spectrometer. Uric acid was listed as a candidate for (1), and Hypoxanthine, Inosine, and Cystine were listed as candidates for (2). In Validation, (1) Uric acid had AUC 0.75, and (2) Hypoxanthine, Inosine, Proline, and Cystine had AUC 0.74, 0.73, 0.74. It was possible to evaluate the malignancy from the metabolite concentration and distinguish between oligodendroglioma and astrocytoma.

  16. Pathophysiology of schizophrenia and abnormalities of the hippocampal glutamatergic nervous system: an MRS analysis based on the affective pathway hypothesis.

    Ito Fumiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2022/03/31

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    The purpose of this study was to examine the association between brain region (hippocampus), neurological function (glutamate), risk factors (psychological trauma), and clinical stage to provide useful indicators for the pathophysiology and treatment of schizophrenia. However, due to changes in the study members, the study plan needed to be reconsidered. Brain structural imaging analysis was conducted based on data on early psychosis obtained in the past. Abnormalities in brain structures (gray matter volume, white matter volume, and white matter microstructure) related to hallucinations in early psychosis were examined. The results indicated that abnormalities in white matter microstructure of language-related brain networks may be related to hallucinations in early psychosis. These results have implications for the process of hallucinations.

  17. Estimation of human blood oxygenation using IVIM imaging.

    TAMURA Hajime

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2022/03/31

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    We investigated whether blood flow and oxygen metabolism in the body could be evaluated using MRI diffusion-weighted images. As basic research, we designed a 3-dimensional unicursal channel phantom to simulate small vessels and obtained diffusion-weighted images with varying infusion rate of water. The signal intensities were compared with theoretical data by numerical computation. Our model may allow for understanding the behavior of IVIM images under various flow conditions and evaluating performance of MRI platforms. Human studies revealed the nature of the brain and kidney diffusion image data. Although it cannot be said that the oxygen saturation of blood can be surely obtained, suppression of the influence of data noise may be necessary with carefully combining multiple imaging conditions.

  18. Radiation cognitive impairment: Elucidation of onset mechanism by Advanced MR and verification by animal model

    Mugikura Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2021/03/31

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    In this study, we will elucidate the onset mechanism of radiation cognitive impairment using Advanced MRI in long-term survivors of childhood cancer and verify it in post-irradiation cognitive impairment mice. In childhood cancer long-term survivors, microstructural changes and brain activity changes were quantified using Advanced MR including T2 star. In addition, the same subject was subjected to an adult function test and a function test, which are cognitive function tests, and the test results were quantified and analyzed. At the same time, a QOL evaluation was performed on the same subject using a questionnaire. In addition to the above cognitive function test and QOL evaluation, data including basic patient information was organized.

  19. 口腔癌の顎骨浸潤と浮腫・炎症の鑑別に有効な客観的画像診断指標の確立

    村田 隆紀, 阪本 真弥, 麦倉 俊司, 高橋 昭喜, 田村 元

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2017/04/01 - 2021/03/31

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    口腔癌では顎骨への癌の直接浸潤の有無や浸潤の範囲を正確に診断することが治療方針の決定に重要であるが、従来の画像診断ではこれらを正確に評価することが困難で、客観的な指標はなかった。われわれは「口腔癌の顎骨浸潤（腫瘍）」と「骨髄浮腫・炎症 (非腫瘍)」の鑑別に有効な客観的画像指標の確立をめざし、320列面検出器CT、3テスラMRIの特殊撮像であるnon-EPI拡散強調画像によるADC、motion sensitized driven equilibrium（MSDE）法、ダイナミック造影MRIのtime intensity curve (TIC) による検討を行った。320列面検出器CTでは歯科治療後の金属からのアーチファクトを低減する手法を組み合わせることで骨浸潤の診断能は向上したが、腫瘍の進展範囲の評価は十分ではなかった。Non-EPI拡散強調画像に関しては、ゆがみの少ない画像を得ることができ、浮腫や炎症などの非腫瘍に比して腫瘍では低いADCを示す傾向が見られ、両者の鑑別に有用と考えられた。ただし、歯科治療後の金属からのアーチファクトが強い場合にはADC値の信頼性が低下する場合があり、今後の課題と思われた。MSDEでの造影領域は偽陽性の場合もあり、他の撮像法と組み合わせが必要であった。TIC の検討では、viable な腫瘍の多くがrapid-plateau pattern を呈するのに対し、骨髄浮腫・炎症など非腫瘍では rapid-persistent patternを示す傾向が見られ、両者の鑑別に有用と考えられた。 従来の撮像法では難しかった「口腔癌の顎骨浸潤（腫瘍）」と「骨髄浮腫・炎症 (非腫瘍)」の鑑別に関し、本研究で用いた320列面検出器CTでの骨の評価および3テスラMRIによる特殊撮像を組み合わせることで診断能が向上する可能性が示された。

  20. Noninvasive biomarker for the assessment for glioma subtype and the response to treeatment

    KANAMORI MASAYUKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    In this study, we evaluated the metabolic product of tumor by a noninvasive or quick method to help a preoperative or intraoperative diagnosis and early prediction of response to treatment. To this end, we established a rapid method to evaluate the metabolic product in vivo and with 1H-MR spectroscopy and mass spectrometry. We found the metabolic products for prediction of the prognosis and the molecular diagnosis.

  21. Intravoxel-incoherent-motion (IVIM) MRI as a noninvasive method for estimating cerebral blood volume in ischemic brain disease

    Tamura Hajime

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Intravoxel-incoherent-motion (IVIM) MRI is a noninvasive method for investigating vascular as well as extra-vascular component in living tissue by use of diffusion-weighted MRI. We investigated if this noninvasive method is useful for estimating cerebral blood volume in ischemic brain disease. We found that the vascular component was detectable, but observed signals were small in the study of normal volunteers. There were regions where reliable information was difficult to obtain such as parts of the frontal brain region.In clinical study, the vascular component was detectable for ischemic disease because of dilatation of blood vessels in those situations. We also found that blood oxygenation of the vascular components could be estimated.

  22. Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm

    TAKAHASHI Shouki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Postoperative infarctions following surgical repair of anterior communicating artery (ACoA) aneurysms are classified as involvement of the subcallosal artery (the largest unpaired perforator of the ACoA), the recurrent artery of Heubner (RAH), or a combination of both. Postoperative amnesia is most likely caused by an infarction in the territory of the subcallosal artery, particularly in the column of the fornix, a constituent of the Papez neuronal circuit. Infarction in the RAH territory alone is unlikely to cause significant amnesia. Infarcted foci in the RAH territory, when associated with a subcallosal artery infarction, can cause considerable frontal dysfunction due to impaired frontostriatal circuits in patients with postoperative amnesia, with resultant worsening of the long-term outcome or quality of life.

  23. Cognitive impairment and MRI of long-term survivors of pediatric cancer

    MUGIKURA Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2018/03/31

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    We sought to determine effects of radiation field size and dose on the extent of developing cavernous malformations in long-term survivors of pediatric cancer.The study involved 34 patients with a history of intracranial germ cell tumors treated with either whole-brain or reduced-field irradiation and undergoing MRI with a mean follow-up of 18.5 years. A total of 235 cavernous malformation lesions were observed in 32 of 34 patients. The mean number of lesions was 2.3 times as high in the whole-brain group as in the reduced-field group. The number of lesions in high-dose fields was significantly larger than in low-dose or untreated fields. Radiation field size and dose were positively associated with the number of cavernous malformations developed. Cavernous malformations can be used as a surrogate marker for microvascular injury following intracranial irradiation in long-term cancer survivors.

  24. Perfusion imaging of the pancreas using an arterial spin labeling technique on 3.0T MRI; initial experience

    Masashi Tsuda, SYUNJI Mugikura, MATSUURA Tomonori, HIROTA Morihisa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    Magnetic resonance imaging with arterial spin labeling is a non-invasive approach to measure organ perfusion. The purpose of this study was to determine the feasibility of using quantitative magnetic resonance imaging (MRI) with non-invasive flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) technique to assess pancreas perfusion on 3.0 T MRI. Perfusion imaging in two different parts of the pancreas undergone in 6 healthy volunteers (6 male, mean age 39 years, range 28-49 years).ASL perfusion was acquired in all volunteers and assessment of pancreatic tissue perfusion was possible. Mean perfusion values were 216 +/- 56 mL/100g/min in the head/body and 148 +/- 35 mL/100g/min in the tail of the pancreas. The quantitative measurement of pancreas perfusion by MRI with FAIR ASL technique could provide a non-invasive method for monitoring the status of blood flow without requiring the administration of a contrast agent.

  25. MRI examination under virtual reality: neuropsychological analysis and clinical application to clastrophobia and pediatric patients.

    MUGIKURA Shunji, TAKAHASHI Shoki, MATSUMOTO Kazuki, KUMABE Toshihiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2011/04/28 - 2015/03/31

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    We examined whether MRI examination under virtual reality are feasible for claustrophobia and young pediatric patents. We evaluated neuropsychological analysis and clinical application. Our results indicate that non invasive MRI examination under virtual reality are useful for claustrophobia and young pediatric patents.

  26. Usefulness of the 3 tesla MRI in the differential diagnosis between recurrence of glioma and non-tumoral treatment related changes including radiation necrosis.

    TAKAHASHI Shoki, MUGIKURA Shunji, MURATA Takaki, WATANABE Mika, KUMABE Toshihiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2011 - 2013

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    We determined whether 3 tesla MRI is useful in distinguishing recurrence of glioma from post-treatment changes including radiation necrosis. MRI sequences in this study included contrast-enhanced perfusion weighted imaging (PWI), apparent diffusion coefficient (ADC), susceptibility weighted images (SWI) and MR spectroscopy (MRS). PWI with double-dosed contrast agent was robust sequence for evaluation of CBV and is useful for discrimination between recurrence of gliomas and post-treatment changes. However, bevacizumab, a newly introduced drug which reduces tumor neoangiogenesis, may underestimate CBV, leading to misdiagnose viable tumor as treatment related change. Further evaluation is needed for PWI under administration of bevacizumab. As for ADC, one of the hopeful sequences, recurrence of gliomas had a propensity to show lower ADC value than treatment related changes. SWI and MRS revealed considerable overlaps between two entities. Future quantitative analysis may be promising.

  27. Development of clinical marker to predict longitudinal prognosis of early psychosis

    MATSUMOTO Kazunori, MATSUOKA Hiroo, MUGIKURA Syunji, TOMITA Hiroaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2010 - 2012

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    To develop useful and reliable clinical markers to predict the longitudinal prognosis of early psychosis, we investigated clinical variables of at risk mental state (ARMS) and first episode psychosis (FEP) at intake and follow-up. In our sample of 116 patients with ARMS, 14% transited to psychosis. Cognitive performance improved to a greater extent in patients with ARMS than in those with FEP. The present findings indicate the importance of using multiple clinical variables in combination to assess and predict the functionalprognosis of early psychosis.

  28. Neuroanatomical and neurochemical substrates for visual hallucinations

    NISHIO Yoshiyuki, HIRAYAMA Kazumi, IIZUKA Osamu, MUGIKURA Syunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2010 - 2012

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    Visual hallucinations are spontaneous phenomena and hard to detect in experimental settings. Tools to evoke visual hallucinations would enable functional neuroimaging investigations and therapeutic intervention studies. We previously devised a new experimental task to detect and measure hallucination-like illusions in patients with dementia with Lewy bodies (DLB) and Parkinson's disease. In the present study, we developed another task to evoke visual illusions, which is easier to administer and has simpler scoring system. Using this new test, we successfully evoked hallucination-like illusory responses in patients with DLB. The number of illusory responses was dramatically reduced by administration of donepezil, a cholinesterase inhibitor. The result suggests the relationship between visual hallucinations and cholinergic insufficiency in DLB.

  29. Neuroimaging and Neuropsychological studies on neural basis of episodic memory

    FUJII Toshikatsu, ABE Nobuhito, MUGIKURA Shunji, MORI Etsuro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2011

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    The functions of various brain areas on the encoding and retrieval of episodic memory have been studied intensely, yet the specific contribution of each brain area has not been elucidated. The purpose of the present study was to identify neural networks that support event memory itself, temporal context memory, spatial context memory, and source memory. For this purpose, we employed both neuroimaging and neuropsychological studies. The results showed (1)the influence of prefrontal activity on medial temporal lobe activity during the retrieval of episodic memory,(2)the crucial role of the medial temporal lobe in the retrieval of source memory, and (3)the differential roles of subregions within the medial temporal lobe in episodic memory.

  30. Can inhaled oxygen be an MR contrast agent as a metabolic biosensor?

    TAMURA Hajime, MUGIKURA Shunji, MACHIDA Yoshio, KINOSHITA Toshibumi, IBARAKI Masanobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2009 - 2011

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    The effects of arterial pressure of oxygen(PaO2)on MRI T2* signal intensity, R1, and cerebral blood flow(CBF)were investigated to know if inhaled oxygen can be an MR contrast agent as a metabolic biosensor. The result showed that it is possible to measure changes in oxygen partial pressure of arterial blood and brain tissue noninvasively by measuring the change in longitudinal relaxation time. In addition, we found the possibility of estimating the amount of tissue oxygen metabolism by measuring simultaneously the end-tidal partial pressures of expired oxygen, the changes in the cerebral blood flow, and the changes in magnetic susceptibility effect.

  31. Neural basis of memory errors

    FUJII Toshikatsu, MORI Etsuro, SUZUKI Maki, MUGIKURA Shunji, OKUDA Jiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2006 - 2008

  32. Neurovascular compression of the rostral ventrolateral medulla related to essential hypertension, MRI study

    TAKAHASHI Shoki, HIGANO Shuichi, MUGIKURA Syunji, UMETSU Atsushi, ABE Takaaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2006 - 2008

  33. Relationship between cognitive impairment and functional MR imaging findings in long term survivor of child hood cancer

    MUGIKURA Shunji, TAKAHASHI Shoki, HIGANO Shuichi, KUMABE Toshihiro, MORI Etsuro, FUJII Toshikatsu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2005 - 2007

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    Purpose: To show the cognitive impairment and functional MR imaging findings in long term survivor of pediatric childhood cancer Method: 30 patients with intracranial germ cell tumor were analyzed. All included patients showed no tumor recurrence at least 5 years after the radiochemotherapy. Neuropsychological examination included memory test, WAIS-R, Wisconsin card sorting test, trail making test, verbal fluency. Functional MR imaging findings included NAA/Cr ratio by findings of Magnetic resonance spectroscopy, number of lacunar hemorrhages examined by T2 weighted imaging and perfusion magnetic resonance imaging findings, 10 normal volunteer were also examined by the same parameters of functional MR imaging findings. Results: Patients with germ cell tumor showed decreased NAA/Cr ration than normal volunteers. Patients with germ cell tumor showed more lacunar hemorrhages than normal volunteers. Perfusion MR findings did not significant difference between patients and normal volunteers. Neuropsychological examination showed mild cognitive impairment in patients group. Conclusion: Functional MR imaging findings were correlated with cognitive impairment in long term survivor of intracranial germ cell tumor

  34. MRI-ASL perfusion imaging -evaluation in pediatric brain and moyamoya disease-

    TAKAHASHI Shoki, HIGANO Shuichi, TAMURA Hajime, SHIRANE Reizo, HAGINOYA Kazuhiro, MUGIKURA Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2002 - 2004

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    1.Cerebral blood flow in MRI-ASL (FAIR) perfusion imaging 2.SPIO Brain Perfusion Imaging : Intraindividually Controlled Randomized Crossover Comparison Study of SPIO versus Gd Our results showed a clinical equivalence of perfusion imaging using SPIO and Gd. 3.MRI-ASL (FAIR) perfusion imaging : Intraindividually Controlled Randomized Crossover Comparison Study of FAIR versus Gd perfusion Our results indicate that good contrast between the cortex and white matter in both FAIR and Gd perfusion. Good positive relation ship was seen between in FAIR and in the relative blood flow or blood volume in Gd perfusion (r = 0.78 and 0.448, respectively). 4.MRI-ASL (FAIR) perfusion imaging in the developing brain Regional pattern of the cerebral bloofd flow derived from FAIR was similar to the PET data reported in the previous literatures, however low signal to noise ratio in FAIR image paused a problem. 5.Posterior Circulation and Ischemic Stroke in Pediatric Moyamoya Disease Our results indicate that reduced leptomeningeal collaterals from affected posterior cerebral artery are closely related to completed strokes rather than transient ischmic attask and transdural collaterals may not be sufficient to compensate for reduced leptomeningeal collaterals. The early involvement of posterior cerebral artery in hemispheres with the less advanced internal carotid artery lesions might be resposnsible for the high prevalence of completed strokes in young children.

  35. Validation of spatial normalization of the brain diffusion tensor imaging (DTI) calculated by statistical parametric mapping (SPM)

    HIGANO Shuichi, MUGIKURA Shunji, TAMURA Hajime, TAKAHASHI Shoki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2001 - 2002

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    Purpose : To validate the accuracy and reproducibility of the spacial normalization of DTI. Materials and methods Subjects include one healthy volunteer, 9 patients without obvious MR abnormality and 6 cases with chronic cereberovascular disease. DTI was obtained using SE type single shot EPI sequence with 6 different direction of motion probing gradients (MPG, b=1000 sec/mm2). In the volunteer, DTI was performed with 6 different imaging parameters. The DTI data were normalized using SPM 99, followed by calculating apparent diffusion coefficient (ADC) images and fractional anisotropy (FA) images. To validate the accuracy of normalization, mismatch of various anatomical landmarks such as cerebral margins, central sulcus, margin of the corpus callosum, Monro foramen, pineal region, center of the middle cerebellar peduncle was measured among cases. To see whether the quantitativeness of ADC and FA was preserved after normalization, correlation of these values between raw images and normalized images was evaluated by defining regions of interest in various brain structures including middle cerebellar peduncle, cerebral peduncle, basal ganglia, thalamus, internal capsule, corpus callosum and centrum semiovale. Results Mismatch of the landmarks among the same cases with different studies was 1.2 mm in average (maximum 8mm). The mismatch among different cases was 2.8 mm in average (max 15mm). The difference between the same cases and the different cases was statistically significant (Mann-Whitney: p<.0001). There was good correlation of ADC and FA values in various structures between raw images and normalized images (r=0.992 in ADC, r=0.989 in FA). The correlation is almost identical in ADC but slightly underestimated in FA. Conclusion Using SPM 99, DTI was well normalized anatomically with preserving quantitativeness, Application of normalization should provide reliable and subjective results in analysis of DTI data obtained from various size/shape of brain with different scan parameters.

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