Details of the Researcher

PHOTO

Taichi Tenkumo
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • 博士（歯学）（北海道大学）

Research History 5

  • 2024/04 - Present
    Tohoku University Graduate School of Dentistry　Division of Advanced Prosthetic Dentistry

  • 2019/04 - 2024/03
    Tohoku University hospital　Senior Lecturer

  • 2012 - 2019/03
    Tohoku University　Graduate school of Dentistry　Assistant professor

  • 2011 - 2012
    University of Duisburg-Essen　Institute for Inorganic Chemistry and Center for Nanointegration Duisburg-Essen

  • 2009 - 2011
    Hokkaido University　Graduate school of Dental Medicine　Assistant professor

Education 3

  • University of Duisburg-Essen　Institute for Inorganic Chemistry and Center for Nanointegration Duisburg-Essen

    2011/11 - 2012/08

  • Hokkaido University　Graduate School of Dental Medicine

    2002/04 - 2006/03

  • Tohoku University　Graduate School of Dentistry

    - 2002/03

Committee Memberships 1

  • 日本口腔インプラント学会　総務委員会 委員

    2024/04 -

Professional Memberships 6

  • 日本顎関節症学会

    2025/06 - Present

  • Japan Prosthodontic Society

    2019/04 - Present

  • 日本インプラント学会

    2018/05 - Present

  • 口腔顔面痛学会

    2018/04 - Present

  • JAPANESE SOCIETY OF PERIODONTOLOGY

    2002/05 - Present

  • Nanobiomedecine

︎Show all ︎Show first 5

Research Areas 3

  • Life sciences / Prosthodontics /

  • Life sciences / Regenerative dentistry and dental engineering /

  • Life sciences / Conservative dentistry and endodontics /

Awards 3

  1. 優秀口演賞

    2024/02　第16回日本義歯ケア学会学術大会　医用材料応用へ向けた100％セルロースナノファイバーの生物学的安全性に関する検討,

  2. 第8回日本歯科医学教育学会国際学会研究発表奨励賞.

    2016/07　DENTAL DIAGNOSIS SIMULATION SOFT

  3. 第7回日本歯科医学教育学会国際学会研究発表奨励賞.

    2015/07　CLINICAL SIMULATION TRAINING UTILIZING INTEGRATED DENTAL TRAINING MODEL

Papers 45

  1. Silver ions and bacteria as promoters of UV-A photocatalysis Peer-reviewed

    Taito Iwabuchi, Taichi Tenkumo, Takayuki Mokudai, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda

    Journal of Photochemistry and Photobiology A: Chemistry　463　2025/06/01

    DOI： 10.1016/j.jphotochem.2025.116269 　

    ISSN： 1010-6030

  2. Enhanced peri-implantitis management through purple-LED irradiation coupled with silver ion application and calcium phosphate gene transfection carrier coating Peer-reviewed

    Taito Iwabuchi, Taichi Tenkumo, Takayuki Mokudai, Masatoshi Takahashi, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda

    Scientific Reports　15　(1)　2025/04/21

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-025-96075-7 　

    eISSN： 2045-2322

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    Abstract The aim of this study was to investigate the bactericidal effect and recovery of biocompatibility of contaminated titanium surfaces using a combination treatment involving silver, copper, or iron ion application along with 400 nm purple-LED light irradiation. Additionally, the study sought to develop a functional calcium phosphate (CaP) coating treatment on titanium surfaces following disinfection, to promote re-osseointegration. A purple-LED emitting light at 400 nm was utilized to irradiate Staphylococcus aureus suspensions and biofilms in the presence of various concentrations of silver, copper, and iron solutions for 1 min. The bactericidal effect and electron spin resonance (ESR) spectrum were subsequently evaluated. Additionally, the hydrophilicity of the titanium surface and cell viability of MC3T3-E1 cells after combination treatment with silver ion was evaluated. Furthermore, a titanium surface coating with CaP gene transfection carrier containing plasmid DNA was developed using an electric current. The activity of hard tissue formation was then evaluated both in vitro and in vivo post-treatment. The bactericidal effect of the combination treatment with silver ions was attributed to the generation of hydroxyl radicals, whereas the effects from iron and copper treatments were not radical-mediated. The silver treatment significantly restored the hydrophilicity and cell affinity of the titanium surface. Moreover, CaP coating applied via an electric current (30 µA for 5 min) enhanced hard tissue formation activity on the titanium surface in both in vitro and in vivo settings. The combination treatment utilizing silver ions and purple-LED irradiation significantly enhanced bactericidal effects by generating high levels of hydroxyl radicals. Additionally, coating the titanium surface with functionalized CaP promoted early osseointegration, suggesting a promising strategy for improving implant outcomes.

  3. Three-dimensional in vivo and finite element analyses of peri-implant bone remodeling after superstructure placement Peer-reviewed

    Itt Assoratgoon, Boyang Wan, Taichi Tenkumo, Tomoya Sato, Tetsuo Kawata, Ramadhan Hardani Putra, Chi Wu, Hiroshi Egusa, Qing Li, Keiichi Sasaki, Yoda Nobuhiro

    The Journal of Prosthetic Dentistry　2025/02

    DOI： 10.1016/j.prosdent.2025.01.015 　

  4. Effectiveness of Fully Remote Practical Training in Dental Education: A Case Study Using Video Conferencing and Communication Tools for the Preparation of Removable Partial Dentures Peer-reviewed

    Lin Chih Ting, Taichi Tenkumo, Kenta Shobara, Hirofumi Yamaguchi, Rie Koide, Toru Ogawa, Keiichi Sasaki, Nobuhiro Yoda

    Jordan Journal of Dentistry　2025

    Publisher: Jordan University of Science and Technology

    DOI： 10.14525/jjd.v2i1.02 　

    eISSN： 3007-536X

    More details Close

    Objectives: This study aimed to evaluate the effectiveness of fully remote practical training for the preparation of removable partial dentures, using the video meeting platform Zoom and the communication app. LINE. Materials and Methods: Remote training was applied for one student using Zoom and LINE at the same time as in-person training for the rest of the class. Consumable and instruments needed were delivered to the student subject to remote training in advance. The student’s work was assessed in front of a web camera, at a pre-determined checkpoint during each step. The actual appliances were then mailed to the instructors and reevaluated. The extent of agreement among the assessors for the video-based and direct evaluations, as well as the extent of agreement between the video-based and direct evaluations were calculated. Results: The introduction of Zoom facilitated mutual communication between the student and the instructors. LINE has proven beneficial for practical training. A fully remote practical training class can be conducted smoothly by assigning a dedicated instructor for remote training. The Κ coefficient for agreement between monitor-based and direct evaluations was 0.704 ± 0.12. The survey results indicated that this practical training style was effective in enhancing knowledge and skills. Conclusions: Fully remote blended learning practical training is feasible using Zoom and LINE; however, the tasks to be conducted must be carefully selected. This study is a case report of a single student; thus, future studies should involve fully remote training of small groups to evaluate its educational effectiveness.

  5. A triple growth factor strategy for optimizing bone augmentation in mice. International-journal Peer-reviewed

    Taichi Tenkumo, Rie Koide, Toru Ogawa, Hirofumi Yamaguchi, Shigeki Suzuki, Makiko Miyashita, Keisuke Nakamura, Han Wang, Nobuhiro Yoda, Keiichi Sasaki

    Journal of biomedical materials research. Part B, Applied biomaterials　112　(7)　e35447　2024/07

    DOI： 10.1002/jbm.b.35447 　

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    With dental implant treatment becoming the gold standard, the need for effective bone augmentation prior to implantation has grown. This study aims to evaluate a bone augmentation strategy integrating three key growth factors: bone morphogenetic protein-2 (BMP-2), insulin-like growth factor 1 (IGF-1), and vascular endothelial growth factor (VEGF). Collagen scaffolds incorporating BMP-2, IGF-1, or VEGF were fabricated and categorized into five groups based on their content: scaffold alone; BMP-2 alone (BMP-2); BMP-2 and IGF-1 (BI); BMP-2, IGF-1, and VEGF (BIV); and BMP-2 and IGF-1 with an earlier release of VEGF (BI + V). The prepared scaffolds were surgically implanted into the calvarias of C57BL/6JJcl mice, and hard tissue formation was assessed after 10 and 28 days through histological, tomographic, and biochemical analyses. The combination of BMP-2 and IGF-1 induced a greater volume of hard tissue augmentation compared with that of BMP-2 alone, regardless of VEGF supplementation, and these groups had increased levels of cartilage compared with others. The volume of hard tissue formation was greatest in the BIV group. In contrast, the BI + V group exhibited a hard tissue volume similar to that of the BI group. While VEGF and CD31 levels were highest in the BIV group at 10 days, there was no correlation at the same time point between hard tissue formation and the quantity of M2 macrophages. In conclusion, the simultaneous release of BMP-2, IGF-1, and VEGF proved to be effective in promoting bone augmentation.

  6. Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis Peer-reviewed

    Jiajun Li, Yukihiko Sakisaka, Eiji Nemoto, Kentaro Maruyama, Shigeki Suzuki, Kaixin Xiong, Hiroyuki Tada, Taichi Tenkumo, Satoru Yamada

    Journal of Dental Sciences　2024/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.jds.2024.02.025 　

    ISSN： 1991-7902

  7. Development of triple-functionalized calcium phosphate nanoparticles as an advanced drug delivery system for bone tissue repair

    Taichi Tenkumo, Benedikt Kruse, Kathrin Kostka, Viktoriya Sokolova, Toru Ogawa, Nobuhiro Yoda, Oleg Prymak, Osamu Suzuki, Keiichi Sasaki, Matthias Epple

    Regenerative Therapy　25　49-60　2024/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.reth.2023.11.010 　

    ISSN： 2352-3204

  8. Introduction of tenomodulin by gene transfection vectors for rat bone tissue regeneration Peer-reviewed

    Han Wang, Taichi Tenkumo, Eiji Nemoto, Yoshiaki Kanda, Toru Ogawa, Keiichi Sasaki

    Regenerative Therapy　22　99-108　2023/03

    DOI： 10.1016/j.reth.2022.12.008 　

    eISSN： 2352-3204

  9. Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis. International-journal Peer-reviewed

    Midori Shirato, Keisuke Nakamura, Taichi Tenkumo, Yoshimi Niwano, Taro Kanno, Keiichi Sasaki, Peter Lingström, Ulf Örtengren

    Clinical oral investigations　27　(2)　739-750　2022/12/09

    DOI： 10.1007/s00784-022-04821-2 　

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    OBJECTIVES: An antimicrobial technique utilizing hydroxyl radicals generated by the photolysis of 3% H2O2 has been developed recently. The present study aimed to evaluate the effect of H2O2 photolysis treatment on tooth demineralization caused by Streptococcus mutans biofilm. MATERIALS AND METHODS: To induce tooth demineralization, S. mutans biofilm was allowed to form on the maxillary first molars collected from Wistar rats via 24-h culturing. The samples were immersed in 3% H2O2 and irradiated with 365-nm LED (H2O2 photolysis treatment). Viable bacterial counts in the biofilm were evaluated immediately after treatment and after an additional 30-h culturing by colony counting. The acidogenicity of the biofilm, re-established 30 h after treatment, was assessed by measuring the pH. The effect of H2O2 photolysis treatment on tooth demineralization was assessed by measuring the depth of the radiolucent layer in micro-CT images. RESULTS: H2O2 photolysis significantly reduced viable bacterial counts in the biofilm to 3.7 log colony forming units (CFU)/sample, while the untreated group had 7.9 log CFU/sample. The pH of the biofilm re-established after treatment (6.6) was higher than that of the untreated group (5.3). In line with the pH measurement, the treatment group had a significantly lower depth of radiolucent layer in dentin than the untreated group. CONCLUSIONS: H2O2 photolysis treatment was effective not only in killing the biofilm-forming S. mutans but also in lowering the acidogenicity of the biofilm. Thus, this technique could inhibit tooth demineralization. CLINICAL RELEVANCE: H2O2 photolysis can be applicable as a new dental caries treatment.

  10. Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapy. International-journal Peer-reviewed

    Chen Xiang, Taichi Tenkumo, Toru Ogawa, Yoshiaki Kanda, Keisuke Nakamura, Midori Shirato, Viktoriya Sokolova, Matthias Epple, Yuya Kamano, Hiroshi Egusa, Keiichi Sasaki

    Acta biomaterialia　119　375-389　2021/01/01

    DOI： 10.1016/j.actbio.2020.11.003 　

    ISSN： 1742-7061

    eISSN： 1878-7568

  11. Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals. International-journal Peer-reviewed

    Taichi Tenkumo, Alkebaier Aobulikasimu, Yoshinori Asou, Midori Shirato, Shunichi Shishido, Taro Kanno, Yoshimi Niwano, Keiichi Sasaki, Keisuke Nakamura

    Scientific reports　10　(1)　8812-8812　2020/06/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-020-65403-4 　

    eISSN： 2045-2322

  12. Bactericidal activity and recovery effect of hydroxyl radicals generated by ultraviolet irradiation and silver ion application on an infected titanium surface. International-journal Peer-reviewed

    Taichi Tenkumo, Kirika Ishiyama, Oleg Prymak, Keisuke Nakamura, Midori Shirato, Toru Ogawa, Makiko Miyashita, Masatoshi Takahashi, Matthias Epple, Taro Kanno, Keiichi Sasaki

    Scientific reports　10　(1)　8553-8553　2020/05/22

    DOI： 10.1038/s41598-020-65411-4 　

    eISSN： 2045-2322

  13. Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste. International-journal Peer-reviewed

    Taichi Tenkumo, Leonardo Rojas-Sánchez, Juan Ramón Vanegas Sáenz, Toru Ogawa, Makiko Miyashita, Nobuhiro Yoda, Oleg Prymak, Viktoriya Sokolova, Keiichi Sasaki, Matthias Epple

    Acta biomaterialia　105　263-279　2020/03/15

    DOI： 10.1016/j.actbio.2020.01.031 　

    ISSN： 1742-7061

    eISSN： 1878-7568

  14. Oral mucosal irritation potential of antimicrobial chemotherapy involving hydrogen peroxide photolysis with high-power laser irradiation for the treatment of periodontitis. International-journal Peer-reviewed

    Midori Shirato, Keisuke Nakamura, Taichi Tenkumo, Yuki Kano, Kirika Ishiyama, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano, Hiroshi Matsuura

    Journal of photochemistry and photobiology. B, Biology　201　111633-111633　2019/12

    DOI： 10.1016/j.jphotobiol.2019.111633 　

    ISSN： 1011-1344

    eISSN： 1873-2682

  15. Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus. Peer-reviewed

    Shiraishi N, Masumoto H, Takahashi K, Tenkumo T, Anada T, Suzuki O, Ogawa T, Sasaki K

    Dent Mater J.　doi: 10.4012/dmj.2018-376.　(1)　148-153　2019/08

    DOI： 10.4012/dmj.2018-376 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  16. パルスジェットを用いたインプラント周囲炎治療システムの開発 インプラントに付着させた人工歯石の除去効果の検討

    飯久保 正弘, 依田 信裕, 松舘 芳樹, 片岡 良浩, 天雲 太一, 山内 健介, 高橋 哲, 小山 重人

    日本口腔インプラント学会誌　32　(2)　E80-E81　2019/06

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  17. Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation. International-journal Peer-reviewed

    Keisuke Nakamura, Midori Shirato, Taichi Tenkumo, Taro Kanno, Anna Westerlund, Ulf Örtengren, Keiichi Sasaki, Yoshimi Niwano

    Scientific reports　9　(1)　4688-4688　2019/03/18

    DOI： 10.1038/s41598-019-41126-z 　

    eISSN： 2045-2322

  18. Prolonged release of bone morphogenetic protein-2 in vivo by gene transfection with DNA-functionalized calcium phosphate nanoparticle-loaded collagen scaffolds Peer-reviewed

    Taichi Tenkumo, Juan Ramón Vanegas Sáenz, Keisuke Nakamura, Yoshinaka Shimizu, Viktoriya Sokolova, Matthias Epple, Yuya Kamano, Hiroshi Egusa, Tsutomu Sugaya, Keiichi Sasaki

    Materials Science and Engineering C　92　172-183　2018/11/01

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.msec.2018.06.047 　

    ISSN： 0928-4931

  19. Introduction of Integrated Dental Training Jaw Models and Rubric Criteria. Peer-reviewed

    Taichi Tenkumo, Takeshi Fuji, Motohide Ikawa, Shigeru Shoji, Hiromi Sasazaki, Yoko Iwamatsu-Kobayashi, Yayoi Okuyama, Hiroyuki Matsui, Naru Shiraishi, Toshi Furuuchi, Keisuke Higuchi, Wataru Hashimoto, Yasuhisa Takeuchi, Hidetoshi Simauchi, Keiichi Sasaki

    European Journal of Dental Education　2018/10

  20. The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in beagle dogs. Peer-reviewed

    Toru Ogawa, Shuhua Wang, Sheng Zheng, Makiko Miyashita, Taichi Tenkumo, Zhiyuan Gu, Wenhai Lian, Keiichi Sasaki

    Journal of Prosthodontic Research　62　(4)　497-502　2018/10

    DOI： 10.1016/j.jpor.2018.07.004 　

    ISSN： 1883-1958

  21. Potential adverse effects of antimicrobial chemotherapy based on ultraviolet-A irradiation of polyphenols against the oral mucosa in hamsters and wounded skin in rats. International-journal Peer-reviewed

    Keisuke Nakamura, Taichi Tenkumo, Takayuki Mokudai, Midori Shirato, Kirika Ishiyama, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano

    Journal of photochemistry and photobiology. B, Biology　187　96-105　2018/10

    DOI： 10.1016/j.jphotobiol.2018.08.006 　

    ISSN： 1011-1344

    eISSN： 1873-2682

  22. Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles Peer-reviewed

    Juan Ramon Vanegas Saenz, Taichi Tenkumo, Yuya Kamano, Hiroshi Egusa, Keiichi Sasaki

    PLOS ONE　12　(11)　2017/11

    DOI： 10.1371/journal.pone.0188347 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  23. 標準化された病態顎模型を用いた客観的歯科臨床技能評価方法の開発(第4報)

    秋葉 奈美, 天雲 太一, 冨士 岳志, 首藤 崇裕, 小野 和宏, 吉羽 邦彦, 二川 浩樹, 津賀 一弘, 田地 豪, 加藤 功一, 佐々木 啓一, 魚島 勝美, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　36回　118-118　2017/07

    Publisher: (一社)日本歯科医学教育学会

  24. 連携機能を活用した歯学教育高度化プログラム

    竹石 龍右, 加来 咲子, 天雲 太一, 冨士 岳志, 三村 純代, 首藤 崇裕, 石田 陽子, 秋葉 奈美, 魚島 勝美, 小野 和宏, 高橋 信博, 二川 浩樹, 加藤 功一, 佐々木 啓一, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　36回　125-125　2017/07

    Publisher: (一社)日本歯科医学教育学会

  25. 大学間連携共同教育推進事業におけるバイオデンタル教育の実施

    首藤 崇裕, 二川 浩樹, 三村 純代, 木原 琢也, 田地 豪, 菅井 基行, 石田 陽子, 竹石 龍右, 加来 咲子, 天雲 太一, 冨士 岳志, 佐々木 啓一, 前田 健康, 加藤 功一

    広島大学歯学雑誌　49　(1)　74-75　2017/06

    Publisher: 広島大学歯学会

    ISSN： 0046-7472

  26. Gene transfection of human mesenchymal stem cells with anano-hydroxyapatite-collagen scaffold containing DNA-functionalized calcium phosphate nanoparticles Peer-reviewed

    Taichi Tenkumo, Juan Ramon Vanegas Saenz, Yukyo Takada, Masatoshi Takahashi, Olga Rotan, Viktoriya Sokolova, Matthias Epple, Keiichi Sasaki

    GENES TO CELLS　21　(7)　682-695　2016/07

    DOI： 10.1111/gtc.12374 　

    ISSN： 1356-9597

    eISSN： 1365-2443

  27. Cutting efficiency of diamond burs operated with electric high-speed dental handpiece on zirconia Peer-reviewed

    Keisuke Nakamura, Yusuke Katsuda, Shuhei Ankyu, Akio Harada, Taichi Tenkumo, Taro Kanno, Yoshimi Niwano, Hiroshi Egusa, Percy Milleding, Ulf Ortengren

    EUROPEAN JOURNAL OF ORAL SCIENCES　123　(5)　375-380　2015/10

    DOI： 10.1111/eos.12211 　

    ISSN： 0909-8836

    eISSN： 1600-0722

  28. 標準化された病態顎模型を用いた客観的歯科臨床技能評価方法の開発(第2報)

    魚島 勝美, 天雲 太一, 竹内 裕尚, 小野 和宏, 吉羽 邦彦, 秋葉 奈美, 二川 浩樹, 津賀 一弘, 田地 豪, 首藤 崇裕, 三村 純代, 菅井 基行, 佐々木 啓一, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　34回　81-81　2015/07

    Publisher: (一社)日本歯科医学教育学会

  29. 大学間連携共同教育推進事業におけるバイオデンタル教育の実施

    三村 純代, 二川 浩樹, 田地 豪, 石田 陽子, 竹石 龍右, 天雲 太一, 竹内 裕尚, 首藤 崇裕, 佐々木 啓一, 前田 健康, 菅井 基行

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　34回　162-162　2015/07

    Publisher: (一社)日本歯科医学教育学会

  30. 3大学(新潟大学、東北大学、広島大学)合同短期留学における、タイ・コンケン大学の歯学教育との比較検討

    佐藤 新一, 田所 大典, 中村 吉秀, 大槻 里実, 亀山 亜美, 鈴木 麻里恵, 柏 美砂, 根本 恭利, 石田 陽子, 竹石 龍右, 竹内 裕尚, 天雲 太一, 洪 光, 岡 広子, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　34回　165-165　2015/07

    Publisher: (一社)日本歯科医学教育学会

  31. Electrochemical evaluation of the corrosion resistance of cup-yoke-type dental magnetic attachments Peer-reviewed

    Yukyo Takada, Masatoshi Takahashi, Akira Kikuchi, Taichi Tenkumo

    DENTAL MATERIALS JOURNAL　33　(6)　859-864　2014/12

    DOI： 10.4012/dmj.2014-162 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  32. 標準化された病態顎模型を用いた客観的歯科臨床技能評価方法の開発

    天雲 太一, 竹内 裕尚, 島内 英俊, 小野 和宏, 吉羽 邦彦, 藤井 規孝, 石田 陽子, 二川 浩樹, 津賀 一弘, 田地 豪, 菅井 基行, 佐々木 啓一, 前田 健康, 魚島 勝美

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　33回　71-71　2014/07

    Publisher: (一社)日本歯科医学教育学会

  33. 大学間連携共同教育推進事業「連携機能を活用した歯学教育高度化プログラム」

    前田 健康, 佐々木 啓一, 菅井 基行, 石田 陽子, 小川 友里奈, 竹内 裕尚, 天雲 太一, 峯 裕一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　32回　147-147　2013/07

    Publisher: (一社)日本歯科医学教育学会

  34. 磁気シールド材料としてのTiとSUS 447J1のレーザー溶接 Peer-reviewed

    高田雄京, 高橋正敏, 菊地 亮, 佐藤秀樹, 泉田明男, 中村好徳, 田中貴信, 天雲太一

    日磁歯誌　22　(1)　90-95　2013

  35. 海外製歯科用磁性アタッチメントを構成する材料と内部構造， Peer-reviewed

    高田雄京, 高橋正敏, 木内陽介, 中村好徳, 田中貴信, 佐藤秀樹, 泉田明男, 天雲太一

    日磁歯誌　22　(1)　96-102　2013

  36. 東北大学歯学部・歯学研究科における新機軸の教育研究の展開(解説),

    佐々木 啓一, 竹内 裕尚, 天雲 太一, 洪 光, 真柳 弦, 西岡 貴志, 鈴木 治, 高橋 信博, 小坂 健

    みちのく歯学会雑誌　44　(1-2)　17-21　2013

    ISSN： 0385-0099

  37. Protamine increases transfection efficiency and cell viability after transfection with calcium phosphate nanoparticles Peer-reviewed

    Taichi Tenkumo, Olga Rotan, Viktoriya Sokolova, Matthias Epple

    Nano Biomedicine　5　(2)　64-74　2013

    DOI： 10.11344/nano.5.64 　

    ISSN： 1883-5198

    eISSN： 2185-4734

  38. Effect of nano-hydroxyapatite on bone morphogenetic protein-2-induced hard tissue formation and dentin resorption on a dentin surface Peer-reviewed

    Hiroki Tamagawa, Taichi Tenkumo, Tsutomu Sugaya, Masamitsu Kawanami

    APPLIED SURFACE SCIENCE　262　(262)　140-145　2012/12

    DOI： 10.1016/j.apsusc.2012.03.103 　

    ISSN： 0169-4332

  39. BMP-2の担体としてのナノハイドロキシアパタイト-コラーゲン-フィブリン複合体の研究 Peer-reviewed

    天雲 太一, 佐々木 啓一

    東北大学歯誌　31　(2)　95-101　2012

  40. Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end Peer-reviewed

    Kaori Otani, Tsutomu Sugaya, Mahito Tomita, Yukiko Hasegawa, Hirofumi Miyaji, Taichi Tenkumo, Saori Tanaka, Youji Motoki, Yasuhiro Takanawa, Masamitsu Kawanami

    DENTAL MATERIALS JOURNAL　30　(4)　485-492　2011/07

    DOI： 10.4012/dmj.2010-158 　

    ISSN： 0287-4547

  41. ナノハイドロキシアパタイト-コラーゲン複合体のハイドロキシアパタイト含有量がrhBMP-2による異所性骨形成に及ぼす影響

    天雲 太一, 菅谷 勉, 川浪 雅光, 亘理 文夫

    日本歯周病学会会誌　51　(春季特別)　131-131　2009/04

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  42. Effect of calcium phosphate content in nanohydroxyapatite- collagen composite foil with BMP-2 application on ectopic bone formation

    Tenkumo Taichi, Sugaya Tsutomu, Kawanami Masamitu, Watari Fumio

    Program and Abstracts of Annual Meeting of the Japanese Society of Periodontology　2009　(0)　114-114　2009

    Publisher: JAPANESE SOCIETY OF PERIODONTOLOGY

    DOI： 10.14833/amjsp.2009s.0.114.0 　

  43. Effect of crosslinking agent in nanohydroxyapatite-collagen composite on ectopic bone formation with BMP-2 application. Peer-reviewed

    Tenkumo T, Sugaya T, Kawanami M, M Gelinsky, Watari F

    Nano Biomedicine　1　(1)　26-33　2009

    DOI： 10.11344/nano.1.26 　

    ISSN： 1883-5198

    eISSN： 2185-4734

  44. Effects of nanohydroxyapatite content on bone formation in nanohydroxyapatite-collagen composite membrane with BMP-2 application. Peer-reviewed

    Tenkumo T, Sugaya T, Kawanami M, Watari F

    Nano Biomedicine　2　(1)　159-166　2009

    DOI： 10.11344/nano.1.159 　

    ISSN： 1883-5198

    eISSN： 2185-4734

  45. Effect of different dentin conditioings on hard tissue formation and dentin resorption by rhBMP-2 application to the dentin surface. Peer-reviewed

    4　(47)　269-279　2005/10

Show all ︎Show first 5

Misc. 31

  1. 感染チタン表面における銀イオンと青色LED処理のヒドロキシラジカル誘発(発生)作用による新規治療法の検討

    岩渕 太人, 天雲 太一, 小川 徹

    日本歯科理工学会誌　42　(Special Issue WINTER)　8-8　2023/12

    Publisher: (一社)日本歯科理工学会

    ISSN： 1884-4421

  2. Effect of growth factor cocktails for bone augmentation of mouse

    Taichi Tenkumo, Rie Koide, Toru Ogawa, Hirofumi Yamaguchi, Shigeki Suzuki, Makiko Miyashita, Keisuke Nakamura, Han Wang, Nobuhiro Yoda, Keiichi. Sasaki

    Interface Summer Seminar 2023　2023/08

  3. 銀イオンと青色LEDを用いた感染チタンの殺菌と表面性状回復効果に関する基礎的検討

    岩渕 太人, 天雲 太一, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　15　(特別号)　246-246　2023/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  4. セルロースナノファイバーの生物学的安全性および吸水性に関する基礎的検討

    山田 有紀江, 小川 徹, 洪 光, 小出 理絵, 天雲 太一, 橋場 洋美, 稲用 亨, 謝 子き, 濱田 泰三, 佐々木 啓一

    日本補綴歯科学会誌　15　(特別号)　273-273　2023/05

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  5. ビデオ会議システムとコミュニケーションアプリを併用した遠隔実習の試み

    林 致廷, 天雲 太一, 庄原 健太, 小出 理絵, 小川 徹, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　40回　74-74　2021/11

    Publisher: (一社)日本歯科医学教育学会

  6. 遺伝子導入剤を含有したナノハイドロキシアパタイトーコラーゲンscaffoldの開発

    天雲 太一, 中村 圭祐, 佐々木 啓一, 菅野 太郎

    日本歯周病学会会誌　60　(春季特別)　130-130　2018/05

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  7. 遺伝子導入剤を含有したナノハイドロキシアパタイトーコラーゲンscaffoldの開発

    天雲 太一, 中村 圭祐, 佐々木 啓一, 菅野 太郎

    日本歯周病学会会誌　60　(春季特別)　130-130　2018/05

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

  8. カフェイン酸に対するUV-A照射で得られる殺菌作用と口腔粘膜刺激性の評価

    中村圭祐, 天雲太一, 目代貴之, 白土翠, 石山希里香, 菅野太郎, 佐々木啓一, 庭野吉己

    日本防菌防黴学会年次大会要旨集　45th　2018

  9. 標準化された病態顎模型を用いた客観的歯科臨床技能評価方法の開発(第4報)

    秋葉 奈美, 天雲 太一, 冨士 岳志, 首藤 崇裕, 小野 和宏, 吉羽 邦彦, 二川 浩樹, 津賀 一弘, 田地 豪, 加藤 功一, 佐々木 啓一, 魚島 勝美, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　36回　118-118　2017/07

    Publisher: 日本歯科医学教育学会

  10. 連携機能を活用した歯学教育高度化プログラム

    竹石 龍右, 加来 咲子, 天雲 太一, 冨士 岳志, 三村 純代, 首藤 崇裕, 石田 陽子, 秋葉 奈美, 魚島 勝美, 小野 和宏, 高橋 信博, 二川 浩樹, 加藤 功一, 佐々木 啓一, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　36回　125-125　2017/07

    Publisher: 日本歯科医学教育学会

  11. アミロライドがオクタアルギニン/リン酸カルシウムを用いた遺伝子導入に及ぼす影響(Amiloride-enhanced gene transfection of octa-arginine functionalized calcium phosphate nanoparticles)

    バネガス・サネンズ・フアンラモン, 天雲 太一, 鎌野 優弥, 江草 宏, 小川 徹, 佐々木 啓一

    日本補綴歯科学会誌　9　(特別号)　276-276　2017/06

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  12. 大学附属病院インプラントセンターにおけるメインテナンスの取り組み

    天雲 太一, 赤塚 亮, 松舘 芳樹, 倉内 美智子, 飯久保 正弘, 小山 重人, 佐々木 啓一

    日本口腔インプラント学会誌　30　(2)　E70-E70　2017/06

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  13. 大学間連携機能を利用した相互乗り入れ講義の取り組み

    加来 咲子, 石田 陽子, 竹石 龍右, 天雲 太一, 竹内 裕尚, 三村 純代, 首藤 崇裕, 小野 和宏, 佐々木 啓一, 菅井 基行, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　100-100　2016/07

    Publisher: 日本歯科医学教育学会

  14. 歯科診断シミュレーションソフトを用いた診断・治療計画立案能力評価システム

    天雲 太一, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　75-75　2016/07

    Publisher: 日本歯科医学教育学会

  15. 標準化された病態顎模型を用いた客観的歯科臨床技能評価方法の開発(第3報)

    田地 豪, 天雲 太一, 竹内 裕尚, 秋葉 奈美, 三村 純代, 首藤 崇裕, 二川 浩樹, 津賀 一弘, 小野 和宏, 吉羽 邦彦, 魚島 勝美, 前田 健康, 佐々木 啓一, 菅井 基行

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　82-82　2016/07

    Publisher: 日本歯科医学教育学会

  16. 日米における歯学部学生の自己評価能力の比較

    大山 弘枝, 天雲 太一, Lee Cliff, 竹内 裕尚, 金高 弘恭, 菊池 雅彦, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　89-89　2016/07

    Publisher: 日本歯科医学教育学会

  17. 連携機能を活用した歯学教育高度化プログラム 平成26〜27年度の実績

    竹石 龍右, 加来 咲子, 天雲 太一, 竹内 裕尚, 三村 純代, 首藤 崇裕, 石田 陽子, 秋葉 奈美, 魚島 勝美, 小野 和宏, 高橋 信博, 二川 浩樹, 佐々木 啓一, 菅井 基行, 前田 健康

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　99-99　2016/07

    Publisher: 日本歯科医学教育学会

  18. 大学間連携機能を活用したバイオデンタル教育の標準化 細胞培養基礎

    首藤 崇裕, 二川 浩樹, 三村 純代, 田地 豪, 石田 陽子, 竹石 龍右, 加来 咲子, 天雲 太一, 竹内 裕尚, 佐々木 啓一, 前田 健康, 菅井 基行

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　102-102　2016/07

    Publisher: 日本歯科医学教育学会

  19. 大学間連携機能を活用したバイオデンタル教育の標準化 ME機器学

    首藤 崇裕, 二川 浩樹, 三村 純代, 田地 豪, 石田 陽子, 竹石 龍右, 加来 咲子, 天雲 太一, 竹内 裕尚, 佐々木 啓一, 前田 健康, 菅井 基行

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　103-103　2016/07

    Publisher: 日本歯科医学教育学会

  20. 大学間連携機能を活用したバイオデンタル教育の標準化 デジタルデンティストリー

    三村 純代, 二川 浩樹, 首藤 崇裕, 田地 豪, 石田 陽子, 竹石 龍右, 加来 咲子, 天雲 太一, 竹内 裕尚, 佐々木 啓一, 前田 健康, 菅井 基行

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　103-103　2016/07

    Publisher: 日本歯科医学教育学会

  21. 統合型病態模型を用いた臨床シミュレーション実習(第3報)

    天雲 太一, 竹内 裕尚, 井川 資英, 小林 洋子, 奥山 弥生, 古内 壽, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　116-116　2016/07

    Publisher: 日本歯科医学教育学会

  22. 海外短期派遣プログラムに参加した学生として東北被災地のために我々ができること

    佐藤 友美, 大内 学, 竹内 裕尚, 天雲 太一, 斎藤 恵一, 洪 光, 岡 広子, 竹石 龍右, 石田 陽子, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　163-163　2016/07

    Publisher: 日本歯科医学教育学会

  23. 統合型病態模型を用いた臨床シミュレーション実習(第2報)

    竹内 裕尚, 天雲 太一, 井川 資英, 奥山 弥生, 古内 壽, 佐々木 啓一

    日本歯科医学教育学会総会・学術大会プログラム・抄録集　34回　109-109　2015/07

    Publisher: 日本歯科医学教育学会

  24. A-15 Development of the nickel free dental magnetic attachment using a magnetic shield composed of a multilayered nitrogen solid-solution phase

    Takada Y, Takahashi M, Kikuchi A, Tenkumo T

    The journal of the Japanese Society for Dental Materials and Devices　34　(2)　118-118　2015/03/25

    Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)

    ISSN： 1884-4421

  25. P-71 Effect of ultrasonic cleaning and storage environment on color difference of titanium specimens in tarnish test

    Takahashi M, Tenkumo T, Takada Y

    The journal of the Japanese Society for Dental Materials and Devices　33　(5)　476-476　2014/09/20

    Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)

    ISSN： 1884-4421

    More details Close

    We performed a tarnish test on titanium and investigated how color difference is affected by the ultrasonic cleaning of the specimens in water and storage environment conditions of a reference specimen. The following results were obtained. 1. Ultrasonic cleaning of titanium specimens in water for 2 minutes after polishing did not affect color difference. 2. Storage environment conditions, especially humidity, affected the color difference of the reference specimens in air. 3. Color difference (ΔE*_<ab>) due to passivation was attributed to ΔL * and Δb*, suggesting that this color difference originates from the difference in the thickness of passivation film.

  26. 窒素固溶ステンレス鋼を用いたNiフリー歯科用磁性アタッチメントの開発

    高田雄京, 高橋正敏, 菊地亮, 天雲太一

    東北大学歯学雑誌　33　(1)　40-40　2014/06/30

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  27. A-26 Corrosion resistance of the magnetic shielding stainless steel composed of solid solution of nitrogen

    Takada Y, Takahashi M, Kikuchi A, Tenkumo T

    The journal of the Japanese Society for Dental Materials and Devices　32　(5)　388-388　2013/09/25

    Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)

    ISSN： 1884-4421

    More details Close

    The magnetic shield material containing no nickel was developed using SUSXM27 stainless steel with absorption of nitrogen gas. After specimens of SUSXM27 were kept at 1200℃ in nitrogen gas at a pressure of 1 atm for 1-10 hours, X-ray diffraction showed nitrogen gas changed an alpha to a gamma phase of the specimens. Anodic polarization curves of the specimens composed of only the alpha and gamma phase respectively were measured in a 0.9%NaCl solution at 37℃. Although pitting corrosion was observed on both specimens, breakdown potentials of the gamma phase were higher than those of the alpha phase.

  28. BMP‐2処理象牙質面における硬組織形成と象牙質吸収のビスフォスフォネート投与による抑制

    本郷哲也, 宮治裕史, 川村直人, 天雲太一, 大谷香織, 得永佳介, 菅谷勉, 川浪雅光

    再生医療　6　279　2007/02/19

    ISSN： 1347-7919

  29. Bisphosphonate投与はBMP‐2処理した象牙質表面へのセメント質様硬組織形成と象牙質吸収を抑制する

    本郷哲也, 宮治裕史, 川村直人, 天雲太一, 大谷香織, 得永佳介, 菅谷勉, 川浪雅光

    日本歯周病学会学術大会プログラムおよび講演抄録集　49th　(秋季特別)　149-149　2006/09/30

    Publisher: (NPO)日本歯周病学会

    DOI： 10.14833/amjsp.2006f.0.75.0 　

    ISSN： 0385-0110

    eISSN： 1880-408X

  30. 象牙質表面処理剤の違いがBMP‐2による硬組織形成と象牙質吸収に及ぼす影響

    天雲太一, 宮治裕史, 川村直人, 伊部敬介, 本郷哲也, 菅谷勉, 川浪雅光

    日本歯周病学会学術大会プログラムおよび講演抄録集　48th　(秋季特別)　78-78　2005/08/20

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  31. 骨髄間質細胞とBMP含有コラーゲンスポンジの併用移植による骨新生

    宮治裕史, 本郷哲也, 天雲太一, 福島千史, 菅谷勉, 川浪雅光

    日本歯周病学会学術大会プログラムおよび講演抄録集　48th　(秋季特別)　101-101　2005/08/20

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

Show all ︎Show first 5

Industrial Property Rights 1

  1. リン酸カルシウム法を用いた遺伝子導入方法、ならびに当該方法に用いる遺伝子導入剤及びキット

    天雲 太一, バネガス サエンズ フアン ラモン, 佐々木 啓一

    特許第6807159号

    Property Type: Patent

Research Projects 21

  1. 感染チタン表面の殺菌・再感染予防・組織再生を有するインプラント周囲炎治療法の開発

    小川 徹, 佐々木 啓一, 日原 大貴, 天雲 太一, 互野 亮, 庄原 健太, 山口 洋史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 国際共同研究加速基金(国際共同研究強化(B))

    Institution: 東北大学

    2022/10/07 - 2027/03/31

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    本研究は、リン酸カルシウムナノ粒子を基材とした遺伝子導入剤を、DefensinやMagaininなど様々な抗菌ペプチドでコーティングすることで口腔内細菌に効果的な抗菌性を示し、かつ歯肉結合組織由来細胞に対して高い遺伝子導入効率を示す組み合わせを検討する。次に遺伝子導入剤内部に抗炎症性を示すsiRNAやBMP-2などの硬組織誘導性細胞賦活因子を発現させるplasmid-DNAなどを複数種搭載させ、骨造成能をin vivoで検証する。これらの結果を基に、インプラント周囲炎に適用し、オステオインテグレーション獲得性を評価する。さらに組織の早期治癒のために高周波振動刺激を行い骨形成促進効果について検討するものである。 R4年度は、可視光・UVC照射装置を購入し、感染チタン表面において銀イオン存在下で青色LEDを照射することで殺菌効果に加え、光触媒活性によるチタン表面性状の回復ができるのではないかという仮説のもと、黄色ブドウ球菌を用いてその検証を行った。 インプラント表面を模倣したチタンディスク（サンドブラスト処理、リン酸エッチング処理後、黄色ブドウ球菌を播種、培養しバイオフィルムを作成）上に、濃度の異なる硝酸銀溶液を加え、青色LEDを1分間照射し、殺菌効果をコロニー形成単位の測定により評価した。また、各処理を行った後のチタン表面の接触角を測定して、表面性状の親水性を評価した。さらに各処理後のチタンディスク上に骨芽細胞様細胞（MC3T3E1）を播種し、培養2日後にMTT試験を行い、細胞親和性の評価を行った。 その結果、銀イオンと可視光領域の青色LED照射の併用法は、浮遊状ならびにバイオフィルムを形成した黄色ブドウ球菌の殺菌作用だけでなく、感染チタン表面の親水性を回復する効果が認められた。

  2. Development of a total therapy for the peri-implantitis made of titanium alloy

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. The influence of loading conditions of dental implants on secondary bone augmentation after mandibular reconstruction with fibula

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  4. Basic study of pure cellulose nanofibers as a bioinert material for clinical application

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  5. 外⼒によって⾻組織再⽣を促す機械刺激 応答型多機能性バイオマテリアルの開発

    Offer Organization: 日本学術振興会

    System: 二国間交流事業

    2023/04 - 2025/03

  6. Mechanistic analysis of bone formation via photobiologic reaction triggered by UVA irradiation

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  7. リン酸カルシウム遺伝子導入剤による機能性抗菌コーティングのインプラント周囲炎応用

    天雲 太一, 石山 希里香, 中村 圭祐, 白土 翠

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    インプラント治療は表面性状の発展に伴い治療の成功率が飛躍的に向上することで、世界的に普及する治療方法となった半面、インプラント周囲炎の報告も増加している。しかし、インプラント周囲炎に対する有効な治療方法はまだないことが歯科治療において大きな問題となっている。インプラント治療では、細菌などで汚染した表面の殺菌療法だけでは不十分で、その後に骨の再付着を誘導するようなシステムの確立が重要となる。そこで、本研究ではラジカル殺菌処置後に抗菌性リン酸カルシウム遺伝子導入ナノ粒子によるコーティング層を構築することで、再感染予防と再オステオインテグレーションの獲得をする新しいインプラント周囲組織再生療法を確立することを目的としている。まず、「リン酸カルシウムコーティング層の作製条件」を検証したところ、照射強度や照射時間は一定量を超えると、リン酸カルシウムの粒子の付着量に変化がなくなり、上限があることが明らかにしてきた。また、殺菌効果については、同じ照射強度、照射時間でも対象となる細菌の濃度には適正濃度があること、その適正濃度は細菌の種類によって異なることが明らかとなった。一方、「CaP コーティング層の表面性状、生体親和性」について解析したところ、菌種によってはリン酸カルシウム自体が細菌の増殖を助長していることが確認された。そこで、新たにこれまでと異なる抗菌ペプチドを付与したリン酸カルシウムナノ粒子を製作し、同細菌に対して殺菌試験を行ったところ、リン酸カルシウム自体による細菌増殖効果が抑制されることが明らかとなった。現在は同リン酸カルシウムナノ粒子の遺伝子導入効率や生体親和性をインプラント周囲に存在する歯周組織関連細胞を用いて検証している。

  8. Development of a novel dental caries therapy based on hydrogen peroxide photolysis Competitive

    Nakamura Keisuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/03 - 2022/04

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    The aim of the present study was to evaluate 1) the antimicrobial activity of hydrogen photolysis treatment against multi-species biofilm containing cariogenic bacteria, and 2) reactions of the dental pulp to the treatment. The hydrogen photolysis treatment is a novel antimicrobial technique in which oxidative power of hydroxyl radicals generated by photo-irradiation of hydrogen peroxide is used. The treatment could effectively reduce viable bacteria in the multi-species biofilm as in the case of single-species biofilm. The reactions of the dental pulp were evaluated in an animal study using rats. The treatment generated localized degenerative tissue at pulp horn region, whereas infiltration of inflammatory cells was not observed. The degenerative tissue was repaired within 5 days, and tertiary dentin formation was observed 21 days after treatment.

  9. 高周波振動刺激の骨形成促進効果を利用したインプラント治療支援機器の開発

    宮下 牧子, 佐々木 啓一, 小川 徹, 天雲 太一, 日原 大貴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2022/03/31

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    歯科インプラントは，欠損補綴における標準的な治療オプションとして歯科臨床において広く普及した．しかしながら，日常臨床においては，欠損部の骨量・骨質が不十分な場合や，骨造成を行った場合，さらには骨粗鬆症や糖尿病など骨治癒不全ケースでは，インプラント埋入後の周囲骨形成が充分になされず，オッセオインテグレーションが獲得されない，もしくは治癒期間が大幅に延長してしまう等の症例が依然として多く存在する．これら理由から治療を断念する患者は，歯科インプラントを希望する患者の実に２割以上に及ぶとされる．このような臨床的課題に対して，薬物による副作用や外科的侵襲を伴わず，安全で，簡便に骨形成とオッセオインテグレーション獲得促進をサポートする支援デバイスの開発は非常に意義深い． 本研究は，歯科インプラント治療支援を目的としたインプラント周囲骨形成・オッセオインテグレーション促進効果をもつ低強度・高周波振動刺激デバイスの開発を目指すものである．アカデミア主導型医療機器開発であり，新規口腔デバイス開発（基礎データ収集，技術の知財化，機器開発），トランスレーショナルリサーチ，非臨床POC(Proof of Concept)の取得という２つのステップから構成される． 昨年度は，ヒト口腔内への応用を想定した小型の刺激デバイスの試作機の設計，口腔内に維持・固定する方法および振動刺激の周波数・強度等の条件の検討を行った．

  10. Improvement of implant osseointegration in osteoporosis patients via modification of intestinal microbiota Competitive

    Kanno Taro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04 - 2022/03

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    The present study aimed to evaluate the potential effects of proanthocyanidin-rich grape seed extract (GSE) on the healing of bone defects as well as implant osseointegration in ovariectomized (OVX) rats, a model of osteoporosis in postmenopausal women. Female Wistar rats were used. The animals underwent OVX operation. One week after OVX surgery, the second surgery was performed to create calvarial bone defects. In addition, one week after the second surgery, implant surgery was performed to install titanium mini-screws in tibiae. During the healing period, GSE or vehicle (water) was daily administered by oral gavage. OVX tended to impair healing of the defects. However, GSE counteracted the OVX-induced impairment in bone healing. Similarly, GSE increased the implant removal torque and bone-to-implant contact compared to those of the water-administered animals. These findings suggest that oral administration of GSE may be beneficial in dental implant therapy in osteoporosis patients.

  11. Development of next generation drug delivery system using gene transfection vector Competitive

    Kanda Yoshiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04 - 2022/03

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    Protamine-coated multi-shell calcium phosphate (CaP) was developed as a non-viral vector for tissue regeneration therapy in this study. The antibacterial effects of CaP nanoparticles against Streptococcus mutans and Aggregatibacter actinomycetemcomitans increased with an increase in the protamine dose. In the combination treatment with BMP-2 and IGF-1, the concentration ratio of BMP-2 and IGF-1 is an important factor affecting bone formation activity. During gene transfection treatment, BMP-2 and IGF-1 were released simultaneously after gene transfer; the loaded dose of the plasmid DNA encoding IGF-1 did not impact the BMP-2 or IGF-1 yield or new bone formation ratio in vitro and in vivo. In conclusion, two growth factor-releasing systems were developed using an antibacterial gene transfer vector, and the relationship between the loaded plasmid DNA dose and resultant growth factor yield was determined in vitro and in vivo.

  12. Study of the bacteriostatic mechanism of developed Ti-Ag alloys using microstructure control Competitive

    Takahashi Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04 - 2021/03

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    The aim of this research subject is to study the bacteriostatic mechanism of Ti-Ag alloys. Various titanium alloys were developed and their microstructures and mechanical properties were investigated. The microstructures of Ti-Ag alloys were controlled by the heat treatment. Bacteriostatic action of Ti-Ag alloys whose microstructures were controlled was examined. The bacteriostatic action of massive alpha was superior to that of Ti2Ag. It was found that the bacteriostatic mechanism was different from antibacterial action by Ag ions.

  13. マイクロ波ドライプロセスによるインプラントアバットメントのTiN表面改質法の確立 Competitive

    滝澤 博胤

    Offer Organization: 日本医療研究開発機構（AMED）「橋渡し研究戦略的推進プログラム」

    System: シーズA

    2019/04 - 2020/03

  14. Constructing method for cementoblastic differentiation induced by 1alpha,25-dihydroxy Vitamin D3 Competitive

    Kanaya Sousuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04 - 2020/03

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    100nM 1alpha,25-dihydroxy Vitamin D3 enhanced Cementum protein 1 (CEMP1) and F-spondin gene expressions considered as specific cementoblastic markers in human periodontal ligament cells. 1alpha,25-dihydroxy Vitamin D3 also enhanced Osterix, Runx2, Alkaline phosphatase (ALP), Osteocalcin (OCN) and Bone sialoprotein (BSP) gene expressions which are regarded as important factors for osteoblastic and cementoblastic differentiation and mineralization. These results indicated that 1alpha,25-dihydroxy Vitamin D3 regulates periodontal ligament cells differentiation. Furthermore, Cells strongly expressed CEMP1 protein were appeared with long term 1alpha,25-dihydroxy Vitamin D3 stimulation. 100nM 1alpha,25-dihydroxy Vitamin D3 decreased mineralized nodule formation. 100nM 1alpha,25-dihydroxy Vitamin D3, Ascorbic acid, beta-glycerophosphate and dexamethazone enhanced mineralized nodule formation, however CEMP1 protein expression was decreased compared with 1alpha,25-dihydroxy Vitamin D3 alone.

  15. Basic study of peri-implantitis treatment aimed at reosseointegration using hydroxyl radical

    Shirato Midori, NIWANO yoshimi, NAKAMURA keisuke, TENKUMO taichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    This study aimed to evaluate the capability of treatment based on hydroxyl radical for peri-implantitis. In the study, sandblasted titanium discs were used as specimens. Firstly, treated specimens were observed to investigate the effect of this treatment on a titanium surface. There were not significant differences between treated discs and untreated discs. Then I analysed proliferation of mouse osteoblastic cells (MC3T3-E1) cultured on the treated discs. Compared with intact discs, biofilm (using Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum and Streptococcus mitis) contamination lowered cell proliferation on the specimen surface,whereas this treatment recovered cell proliferation. These findings suggest that treatment based on hydroxyl radical can recover the degraded biocompatibility of biofilm-contaminated titanium surfaces without damage and can potentially be utilised for peri-implantitis treatment.

  16. Development of new dental pulp treatment using gene silencing and synthesis of fluoroapatite. Competitive

    Tenkumo Taichi, Sasaki keiichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04 - 2019/03

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    The aim of this study is that the development of new dental pulp protection treatment with a Anti-inflammatory effect using gene silencing and regeneration by the fluoroapatite synthesis. In this study, a gene transfection vector based on Calcium phosphate(CaP), which is composed of bone, enamel and dentin, was prepared and evaluated the gene transfection efficiency and cell viability of CaP with different peptide. For rat dental pulp derived (DP) cells, CaP nanoparticles with octa-ariginine or Protamine induced high transfection efficiency and cell viability. Furthermore, this reduced the TNF-a mRNA expression of the rat DP cells stimulated by LPS. These results suggested that the gene silencing using CaP with siRNA(anti-TNF-a) reduced inflammation. On the other hand, the synthesis of fluoroapatite having vertical crystal arrangement against dental surface. Furthermore, the application of CaP with siRNA(anti-TNA-a)reduced the inflammation in histological observation.

  17. Development of functionally gradient bacteriostatic alloys by using laser heat treatment: application to orthodontic anchoring screw Competitive

    Takahashi Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04 - 2018/03

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    Aiming to develop functionally gradient bacteriostatic alloys, we prepared experimental Ti-Ag alloys and investigated their machinability. The machinability of Ti-Ag alloys was superior to that of pure titanium. On the other hand, experimental Ti-Nb-Cu ternary alloys were prepared and investigated their properties. The differences in the mechanical properties are attributable to solid-solution strengthening or to precipitation strengthening by the dual-phase (alpha + beta) structure. Additionally, we developed a simplified fixating device for performing intraoral radiography in beagle dogs.

  18. Establishment of peri-implantitis treatment based on radical disinfection technique Competitive

    Sasaki Keiichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04 - 2018/03

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    In this project, in vitro and in vivo tests were performed with an aim of application of radical disinfection technique to treatment for peri-implantitis. In vivo test, where peri-implantitis caused around implants installed in dogs were treated with radical disinfection technique. However, there was no significant difference between the test and control groups. Thus, to find more suitable treatment conditions, in vitro test was additionally performed. The results demonstrated that the radical disinfection technique could recondition the titanium surface that had been previously contaminated by bacteria for subsequent osteoblastic cells. Therefore, future study should focus more on the establishment of treatment condition that enables to acquire re-osseointegration around the implants suffering from peri-implantitis.

  19. Treatment of vertical root fracture using hybrid between TCP resin composits and nanohydroxyapatite collagen Competitive

    SUGAYA Tsutomu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Hokkaido University

    2014/04 - 2017/03

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    Induction of ectopic hard tissue formation and resin-bonding affinity using αTCP-4META/MMA-TBB resin composits and ascorbic acid/copper chloride or EDC crosslinked nanohydroxyapatite/collagen complex (nHAC) impregnated with BMP-2 were examined in vitro and in vivo in order to improve the clinical outcome of vertical root fracture treatent. As results, a hybrid layer was observed at the interface between resin and bone in both optical microscope and SEM observation, and direct resin-bone contact was observed without connective tissue intervention, when nHAC crosslinked with ascorbic acid/copper chloride was adhered to resin and impregnated with BMP-2 and implanted into connective tissue.

  20. Development of the multi-shell nanohydroxyapatite-collagen scaffold with control system of releasing growth factor Competitive

    Tenkumo Taichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2014/04 - 2016/03

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    Fundamental elements of tissue regeneration include cells, growth factors, and a scaffold. This study aimed to fabricate a growth factor releasing biodegradable scaffold for tissue regeneration. We prepared multi-shell calcium phosphate (CaP) nanoparticles functionalised with DNA, polyethyleneimine (PEI), protamine, and octa-arginine (R8), and compared their respective transfection activity and cell viability measures using human mesenchymal stem cells. These experiments demonstrated that the scaffolds were associated with moderate hMSC cell viability and were capable of releasing the BMP-2 protein into hMSCs following gene transfection. In particular, the scaffold loaded with protamine-containing CaP nanoparticles demonstrated the highest cell viability and transfection efficiency in hMSCs; thus, it might be suitable to serve as an efficient growth factor releasing scaffold.

  21. A development of the bonding treatment of vertically fractured roots with cementum regeneration on 4-META/MMA-TBB resin

    TANAKA Saori, SUGAYA Tsutomu, MIYAJI Hirofumi, KATO Akihito, YOSHIMURA Yoshitaka, IBE Yuko, TENKUMO Taichi, OTANI Kaori, NAKATSUKA Megumi, INOUE Kana, FUKUDA Hiroe, HENMI Masaru, KOSEN Yuta, TAMAGAWA Hiroki, HONMA Keishi, YOKOYAMA Hiroyuki, WASHIZU Taro, KANAYAMA Izumi, SUNOSAKI Maki, NAKAZAWA Atsushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Hokkaido University

    2007 - 2009

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    To improve the bonding treatment of vertically fractured roots, we aimed to the newly cementum formation on a compound of resin and dentin powder, which may improve the binding between resin and cementum. In vitro, cytotoxicity and Micro Tensile Bond Strength (MTBS) test were assessed. It had little cytotoxicity and exhibited higher bond strength. In vivo, in some cases, we observed the newly cementum formation on a compound of resin and dentin powder. This experiment might exhibit a possibility of the newly cementum formation on a resin.

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Teaching Experience 7

  1. 部分床義歯技工学講義　東北歯科技工専門学校

  2. 口腔機能回復学１B　東北大学歯学部

  3. 顎口腔機能学講義　東北歯科技工専門学校

  4. 歯周治療学　北海道ハイテクノロジー専門学校歯科衛生士学科

  5. 歯内療法学　北海道ハイテクノロジー専門学校歯科衛生士学科

  6. 顎口腔機能学　仙台歯科技工士専門学校

  7. 歯科補綴学　仙台保健福祉専門学校

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