Details of the Researcher

PHOTO

Kiyotaka Hao
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • ph.D (Tohoku University)

Professional Memberships 3

  • JAPANESE ASSOCIATION OF CARDIOVASCULAR INTERVENTION AND THERAPEUTICS

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

  • The Japanese Circulation Society

Research Interests 4

  • mitral regurgitation

  • aoritic valve stenosis

  • angina pectoris

  • myocardial infarction

Research Areas 2

  • Life sciences / Cardiology / heart valve disease

  • Life sciences / Cardiology / Ischemic heart disease

Papers 77

  1. Cardiac Allograft Vasculopathy: 5-Year Longitudinal Morphological Changes Assessed by Optical Coherence Tomography. International-journal

    Marina Arai, Kensuke Nishimiya, Jun Takahashi, Kotaro Nochioka, Hideaki Suzuki, Saori Miyamichi-Yamamoto, Hiroyuki Takahama, Hideka Hayashi, Kazuma Ohyama, Tomohiko Shindo, Shigeo Godo, Kiyotaka Hao, Takashi Shiroto, Satoshi Miyata, Yoshikatsu Saiki, Satoshi Yasuda

    JACC. Asia　2026/05/30

    DOI： 10.1016/j.jacasi.2026.04.012 　

  2. 経カテーテル大動脈弁置換術中の経食道心エコーでinfoldingを診断した一例

    船木 崇裕, 羽尾 清貴, 勝田 祐子, 進藤 智彦, 菊池 翼, 後岡 広太郎, 白戸 崇, 鈴木 祐輔, 齋木 佳克, 安田 聡

    超音波医学　52　(Suppl.)　S491-S491　2025/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  3. Clinical Characteristics and Outcome of Patients With Myocardial Infarction With Nonobstructive Coronary Arteries in Japan: Insights From the Miyagi Acute Myocardial Infarction Registry Study. International-journal

    Kiyotaka Hao, Jun Takahashi, Koichi Sato, Kento Fukui, Tomohiko Shindo, Kazuma Oyama, Kensuke Nishimiya, Shigeo Godo, Takashi Shiroto, Hiroaki Shimokawa, Satoshi Yasuda

    Journal of the American Heart Association　14　(5)　e036802　2025/03/04

    DOI： 10.1161/JAHA.124.036802 　

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    BACKGROUND: Clinical characteristics and outcomes of patients with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) are not fully understood, particularly in Japan. METHODS AND RESULTS: We enrolled a total of 8881 patients with acute MI from the Miyagi Acute Myocardial Infarction Registry Study (2012-2020), with a median age of 69 years. Among them, 239 patients (2.7%) were diagnosed with MINOCA. Compared with those with MI with obstructive coronary artery disease (MI-CAD), patients with MINOCA were more often women, had a higher incidence of non-ST-segment-elevation MI and a lower prevalence of dyslipidemia. Compared with patients with MI-CAD, patients with MINOCA in all age groups (<59, 60-69, 70-79, >80 years of age) had a higher incidence of non-ST-segment-elevation MI. Additionally, those ≤59 years of age were more often women and had a lower prevalence of diabetes and dyslipidemia. In-hospital mortality increased with age in patients with MI-CAD (3.9% for <59 years of age, 5.6% for 60-69 years of age, 8.3% for 70-79 years of age, and 15.2% for >80 years of age; P<0.01), but not in patients with MINOCA (4.5%, 7.4%, 6.0%, and 9.6%, respectively; P=0.36). Compared with patients with MI-CAD, patients with MINOCA had lower in-hospital mortality for Killip class IV (40.7% versus 20.0%; adjusted odds ratio [OR], 0.31 [95% CI, 0.10-0.94]; P=0.04) and renal dysfunction (20.0% versus 7.1%; adjusted OR, 0.29 [95% CI, 0.09-0.96]; P=0.04). CONCLUSIONS: Patients with MINOCA exhibit distinct clinical characteristics and outcomes compared with those with MI-CAD, particularly in terms of age, sex, prevalence of comorbidities, and in-hospital mortality. These findings underscore the importance of tailored clinical approaches for patients with MINOCA.

  4. The outcomes of electronic personal health records in patients with heart failure or coronary artery disease International-journal

    Kotaro Nochioka, Satoshi Yasuda, Takashi Shiroto, Saori Yamamoto, Haruka Sato, Yuhi Hasebe, Shigeo Godo, Makoto Nakano, Tomohiko Shindo, Kensuke Nishimiya, Kiyotaka Hao, Jun Takahashi, Keisuke Ido, Yoichi Kakuta, Hiroaki Shimizu, Hiroaki Shimokawa, Masaharu Nakayama

    ESC Heart Failure　12　(2)　1464-1468　2024/11/14

    Publisher: Wiley

    DOI： 10.1002/ehf2.15079 　

    ISSN： 2055-5822

    eISSN： 2055-5822

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    Abstract Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementation of integrated PHRs in patients with heart failure (HF) or coronary artery disease (CAD). Methods This prospective single‐group study evaluated the effects of a PHR system with the capability to capture electronic health records and vital signs in patients with HF or CAD. The outcomes measured were the 6 ‐month changes in blood pressure (BP), body weight (BW), brain natriuretic peptide (BNP) levels, lipid profiles and haemoglobin (Hb) A1c levels. Results Between June 2021 and March 2022, we enrolled 111 patients (median age: 61 years and 47% women) with CAD and/or HF. Over 6 months, the PHR review count distribution was skewed: median 749 times (lowest 2, highest 5724)/180 days, suggesting both low and excessive PHR users. After 3 days, 23% of the patients discontinued inputting their vital signs and medication status. At 6 months, compared with patients who discontinued, those who continued to input their vital signs (N = 86) showed a significant decrease in their systolic BP and LDL‐C levels but not in the diastolic BP, BW, BNP, HDL‐C, triglyceride or HbA1c levels. Conclusions The implementation of smartphone‐based PHRs in daily practice is challenging for patients with HF or CAD. However, we observed positive indications of the benefits of PHR in these patients. Trial registration number UMIN000044369

  5. Characteristics and In-Hospital Outcomes of Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries - Insights From the Real-World JAMIR Database.

    Sho Onuma, Jun Takahashi, Takashi Shiroto, Shigeo Godo, Kiyotaka Hao, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhiko Sakata, Tomonori Itoh, Tetsu Watanabe, Masafumi Watanabe, Morimasa Takayama, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

    Circulation journal : official journal of the Japanese Circulation Society　89　(3)　382-390　2024/10/09

    DOI： 10.1253/circj.CJ-24-0422 　

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    BACKGROUND: Few studies have investigated the clinical characteristics and in-hospital outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) using real-world databases in the coronary intervention era. METHODS AND RESULTS: We conducted a retrospective analysis of 22,236 patients (mean [±SD] age 68±13 years, 23.4% female) enrolled in the Japan Acute Myocardial Infarction Registry (JAMIR) between 2011 and 2016. Based on urgent coronary angiography findings, 286 (1.3%) patients were diagnosed as MINOCA, and the remaining 21,950 (98.7%) as MI with obstructive coronary artery disease (MI-CAD). MINOCA patients were characterized by younger age, fewer coronary risk factors, lower rate of ST-elevation myocardial infarction, lower Killip classification, and lower peak creatinine phosphokinase levels than MI-CAD patients. In-hospital all-cause mortality did not differ between the MINOCA and MI-CAD groups (5.2% vs. 5.7%, respectively; P=0.82). Comparing cause-specific mortality, non-cardiac mortality was higher in the MINOCA than MI-CAD group (4.2% vs. 1.6%; P<0.01). Importantly, non-cardiac death was more prevalent among elderly (≥65 years) than younger (<65 years) patients in the MI-CAD group, whereas this trend was not observed in the MINOCA group. CONCLUSIONS: Analysis of the real-world JAMIR database revealed a relatively high prevalence of non-cardiac death among MINOCA patients, underscoring the need for comprehensive management to improve disease prognosis, particularly in younger patients.

  6. Pathophysiology and diagnostic pathway of myocardial infarction with non-obstructive coronary arteries. International-journal

    Jun Takahashi, Sho Onuma, Kiyotaka Hao, Shigeo Godo, Takashi Shiroto, Satoshi Yasuda

    Journal of cardiology　83　(1)　17-24　2023/07/29

    DOI： 10.1016/j.jjcc.2023.07.014 　

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    Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous and diverse disease entity, which accounts for about 6 % of all acute myocardial infarction (AMI) cases. In patients with chest pain and acute myocardial injury detected by a highly sensitive troponin assay, the absence of epicardial coronary stenosis of 50 % or greater on angiography leads to the working diagnosis of MINOCA. The updated JCS/CVIT/JCC 2023 Guideline described MINOCA as a new disease concept and recommended a multimodality approach to uncovering the underlying causes of MINOCA. Cardiac magnetic resonance (CMR) is useful in not only making a definite diagnosis of MINOCA, but also excluding non-ischemic causes that mimic AMI such as takotsubo cardiomyopathy and myocarditis. Meanwhile, intracoronary imaging, particularly optical coherence tomography (OCT), enables us to evaluate precisely intracoronary morphological alterations including plaque disruption and spontaneous coronary artery dissection which are not revealed by angiographic findings alone. Recent studies have shown that an initial workup with the combination of CMR and OCT could provide a definite diagnosis in a significant percentage of patients suspected of MINOCA. Consecutively, patients with inconclusive results of a series of CMR and OCT implementation are eligible for assessing the potential for coronary functional abnormalities or blood coagulopathy as another factor involved in the development of MINOCA. Although uncovering the pathogenesis of MINOCA might be essential for establishing an individualized treatment approach, significant knowledge gaps in terms of secondary prevention strategies for MINOCA focusing on the improvement of long-term prognosis remain to be overcome. In this review, we summarize our current understanding of MINOCA and highlight contemporary diagnostic approaches for patients with suspected MINOCA.

  7. Calcium-Channel Blockers: An Alternative Therapy to Beta-Blockers for Myocardial Infarction? International-journal

    Kiyotaka Hao, Satoshi Yasuda

    JACC. Asia　3　(3)　455-456　2023/06

    DOI： 10.1016/j.jacasi.2023.04.002 　

  8. Disparity of Performance Measure by Door-to-Balloon Time Between a Rural and Urban Area for Management of Patients With ST-Segment Elevation Myocardial Infarction - Insights From the Nationwide Japan Acute Myocardial Infarction Registry.

    Kento Fukui, Jun Takahashi, Kiyotaka Hao, Satoshi Honda, Kensaku Nishihira, Sunao Kojima, Misa Takegami, Yasuhiko Sakata, Tomonori Itoh, Tetsu Watanabe, Morimasa Takayama, Tetsuya Sumiyoshi, Kazuo Kimura, Satoshi Yasuda

    Circulation journal : official journal of the Japanese Circulation Society　87　(5)　648-656　2023/04/25

    DOI： 10.1253/circj.CJ-22-0454 　

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    BACKGROUND: Although a door-to-balloon (D2B) time ≤90 min is recognized as a key indicator of timely reperfusion for patients with ST-segment elevation myocardial infarction (STEMI), it is unclear whether regional disparities in the prognostic value of D2B remain in contemporary Japan.Methods and Results: We retrospectively analyzed 17,167 STEMI patients (mean [±SD] age 68±13 years, 77.6% male) undergoing primary percutaneous coronary intervention. With reference to the Japanese median population density of 1,147 people/km2, patients were divided into 2 groups: rural (n=6,908) and urban (n=10,259). Compared with the urban group, median D2B time was longer (70 vs. 62 min; P<0.001) and the rate of achieving a D2B time ≤90 min was lower (70.7% vs. 75.4%; P<0.001) in the rural group. In-hospital mortality was lower for patients with a D2B time ≤90 min than >90 min, regardless of residential area, whereas multivariable analysis identified prolonged D2B time as a predictor of in-hospital death only in the rural group (adjusted odds ratio 1.57; 95% confidence interval 1.18-2.09; P=0.002). Importantly, the rural-urban disparity in in-hospital mortality emerged most distinctively among patients with Killip Class IV and a D2B time >90 min. CONCLUSIONS: These data suggest that there is a substantial rural-urban gap in the prognostic significance of D2B time among STEMI patients, especially those with cardiogenic shock and a prolonged D2B time.

  9. MitraClip術中に出現した血栓を経食道心臓超音波検査で確認し塞栓症を回避しえた一例

    粕壁 幸恵, 勝田 祐子, 後岡 広太郎, 千葉 貴彦, 西宮 健介, 神戸 茂雄, 羽尾 清貴, 白戸 崇, 高橋 潤, 安田 聡

    超音波医学　50　(Suppl.)　S613-S613　2023/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  10. The influence of COVID-19 pandemic on management of acute myocardial infarction in Japan; Insight from the Miyagi AMI Registry Study. International-journal

    Kiyotaka Hao, Jun Takahashi, Koichi Sato, Akira Suda, Tomohiko Sindo, Shigeo Godo, Kensuke Nishimiya, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda

    International journal of cardiology. Heart & vasculature　43　101116-101116　2022/12

    DOI： 10.1016/j.ijcha.2022.101116 　

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    Due to the coronavirus disease 2019 (COVID-19) pandemic, the first state of emergency had been declared from April 7 to May 25, 2020, in Japan. This pandemic might affect the management for patients with acute myocardial infarction (AMI). Method and Results: To evaluate the critical care and outcomes of AMI patients during the COVID-19 outbreak, we examined the patients with AMI hospitalized in 2020 (n = 1186) and those in 2017-2019 (n = 4877) using a database of the Miyagi AMI Registry Study. The door-to-device time under the emergency declaration became longer as compared with that of the same period in 2017-2019 [83(65-111) vs 74(54-108) min, p = 0.04]. Importantly, the time delay was noted in only patients with Killip class I on arrival, but not in those with Killip class II-IV. Meanwhile, there were no significant changes in the duration from the symptom onset to hospital arrival, the use rate of ambulance and the performance rate of primary percutaneous coronary intervention before and after the COVID-19 outbreak. Eventually, in-hospital mortality had not deteriorated under the state of emergency (6.7 vs 7.8 %, P = 0.69). Conclusion: The emergence of the COVID-19 outbreak seemed to affect AMI management and highlight understanding the barriers to cardiovascular critical care.

  11. バルーン拡張型TAVI弁留置時にkissing balloon inflationによって左冠動脈から大動脈に突出したステントの変形を回避し得た超高リスク大動脈弁狭窄症の一例

    高橋 亮吉, 西宮 健介, 羽尾 清貴, 菊地 翼, 神戸 茂雄, 勝田 祐子, 進藤 智彦, 白戸 崇, 熊谷 紀一郎, 高橋 潤, 齋木 佳克, 安田 聡

    日本心血管インターベンション治療学会抄録集　30回　[YIA48-8]　2022/07

    Publisher: (一社)日本心血管インターベンション治療学会

  12. 術前フレイルはTAVI後せん妄の最大の予測因子である TAVI半年後の機能予後との関連性

    竹内 雅史, 菊地 翼, 羽尾 清貴, 西宮 健介, 高橋 潤, 安田 聡

    日本心血管インターベンション治療学会抄録集　30回　[CO033]-[CO033]　2022/07

    Publisher: (一社)日本心血管インターベンション治療学会

  13. バルーン拡張型TAVI弁留置時にkissing balloon inflationによって左冠動脈から大動脈に突出したステントの変形を回避し得た超高リスク大動脈弁狭窄症の一例

    高橋 亮吉, 西宮 健介, 羽尾 清貴, 菊地 翼, 神戸 茂雄, 勝田 祐子, 進藤 智彦, 白戸 崇, 熊谷 紀一郎, 高橋 潤, 齋木 佳克, 安田 聡

    日本心血管インターベンション治療学会抄録集　30回　[YIA48-8]　2022/07

    Publisher: (一社)日本心血管インターベンション治療学会

  14. 80歳以上と80歳未満の患者で比較した経カテーテル的大動脈弁置換術の長期死亡率(Comparison of Long-term Mortality of Transcatheter Aortic Valve Implantation between Patients Aged ≧80 Years and those <80 Years)

    菊地 翼, 高橋 潤, 羽尾 清貴, 西宮 健介, 神戸 茂雄, 勝田 祐子, 須田 彬, 進藤 智彦, 白戸 崇, 熊谷 紀一郎, 齋木 佳克, 安田 聡

    日本循環器学会学術集会抄録集　86回　PL10-2　2022/03

    Publisher: (一社)日本循環器学会

  15. Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT. International-journal

    Masashi Takeuchi, Hideaki Suzuki, Yasuharu Matsumoto, Yoku Kikuchi, Kentaro Takanami, Toshihiro Wagatsuma, Jun Sugisawa, Satoshi Tsuchiya, Kensuke Nishimiya, Kiyotaka Hao, Shigeo Godo, Tomohiko Shindo, Takashi Shiroto, Jun Takahashi, Kiichiro Kumagai, Masahiro Kohzuki, Kei Takase, Yoshikatsu Saiki, Satoshi Yasuda, Hiroaki Shimokawa

    PloS one　17　(11)　e0276447　2022

    DOI： 10.1371/journal.pone.0276447 　

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    OBJECTIVES: Delirium is an important prognostic factor in postoperative patients undergoing cardiovascular surgery and intervention, including transcatheter aortic valve implantation (TAVI). However, delirium after transcatheter aortic valve implantation (DAT) is difficult to predict and its pathophysiology is still unclear. We aimed to investigate whether preoperative cerebral blood flow (CBF) is associated with DAT and, if so, whether CBF measurement is useful for predicting DAT. METHODS: We evaluated CBF in 50 consecutive patients before TAVI (84.7±4.5 yrs., 36 females) using 99mTc ethyl cysteinate dimer single-photon emission computed tomography. Preoperative CBF of the DAT group (N = 12) was compared with that of the non-DAT group (N = 38) using whole brain voxel-wise analysis with SPM12 and region of interest-based analysis with the easy-Z score imaging system. Multivariable logistic regression analysis with the presence of DAT was used to create its prediction model. RESULTS: The whole brain analysis showed that preoperative CBF in the insula was lower in the DAT than in the non-DAT group (P<0.05, family-wise error correction). Decrease extent ratio in the insula of the DAT group (17.6±11.5%) was also greater relative to that of the non-DAT group (7.0±11.3%) in the region of interest-based analysis (P = 0.007). A model that included preoperative CBF in the insula and conventional indicators (frailty index, short physical performance battery and mini-mental state examination) showed the best predictive power for DAT (AUC 0.882). CONCLUSIONS: These results suggest that preoperative CBF in the insula is associated with DAT and may be useful for its prediction.

  16. Beneficial effects of exercise training on physical performance in patients with vasospastic angina. International-journal

    Jun Sugisawa, Yasuharu Matsumoto, Masashi Takeuchi, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Ohura, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

    International journal of cardiology　328　14-21　2021/04/01

    DOI： 10.1016/j.ijcard.2020.12.003 　

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    AIMS: In vasospastic angina (VSA), coronary vasomotion abnormalities could develop not only in epicardial coronary arteries but also in coronary microvessels, where calcium channel blockers (CCBs) have limited efficacy. However, efficacy of exercise training for VSA remains to be elucidated. We thus aimed to examine whether vasodilator capacity of coronary microvessels is impaired in VSA patients, and if so, whether exercise exerts beneficial effects on the top of CCBs. METHODS: We performed 2 clinical protocols. In the protocol 1, we measured myocardial blood flow (MBF) using adenosine-stress dynamic computed tomography perfusion (CTP) in 38 consecutive VSA patients and 17 non-VSA controls. In the protocol 2, we conducted randomized controlled trial, where 20 VSA patients were randomly assigned to either 3-month exercise training group (Exercise group) or Non-Exercise group (n= 10 each). RESULTS: In the protocol 1, MBF on CTP was significantly decreased in the VSA group compared with the Non-VSA group (138 ± 6 vs 166 ± 10 ml/100 g/min, P = 0.02). In the protocol 2, exercise capacity was significantly increased in the Exercise group than in the Non-Exercise group (11.5 ± 0.5 to 15.4 ± 1.8 vs 12.6 ± 0.7 to 14.0 ± 0.8 ml/min/kg, P < 0.01). MBF was also significantly improved after 3 months only in the Exercise group (Exercise group, 145 ± 12 to 172 ± 8 ml/100 g/min, P < 0.04; Non-Exercise group, 143 ± 14 to 167 ± 8 ml/100 g/min, P = 0.11), although there were no significant between-group differences. CONCLUSIONS: These results provide the first evidence that, in VSA patients, exercise training on the top of CCBs treatment may be useful to improve physical performance, although its effect on MBF may be minimal.

  17. Prognostic Links Between OCT-Delineated Coronary Morphologies and Coronary Functional Abnormalities in Patients With INOCA. International-journal

    Kensuke Nishimiya, Akira Suda, Kento Fukui, Kiyotaka Hao, Jun Takahashi, Yasuharu Matsumoto, Kiyoto Mitsuishi, Tasuku Watanabe, Kazuma Ohyama, Jun Sugisawa, Satoshi Tsuchiya, Koichi Satoh, Tomohiko Shindo, Shigeo Godo, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa

    JACC. Cardiovascular interventions　14　(6)　606-618　2021/03/22

    DOI： 10.1016/j.jcin.2020.12.025 　

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    OBJECTIVES: Whether there are prognostic links between coronary morphologies and coronary functional abnormalities was examined in ischemia and nonobstructive coronary artery disease (INOCA) patients. BACKGROUND: Although INOCA has attracted much attention, little is known about the prognostic impact of coronary morphologies in this disorder. METHODS: A total of 329 consecutive INOCA patients were enrolled and underwent spasm provocation testing combined with lactate sampling for diagnosis of epicardial and microvascular spasm (MVS). On the basis of the functional tests, the patients were classified into 4 groups: a control group without epicardial spasm or MVS (n = 32), MVS alone (n = 51), diffuse spasm in ≥2 coronary segments (n = 204), and focal spasm in 1 segment (n = 42). In this population, optical coherence tomography imaging of the left anterior descending coronary artery was performed for evaluation of adventitial vasa vasorum (AVV) and intraplaque neovessels (IPN). Index of microcirculatory resistance was also measured. RESULTS: MVS frequently coexisted with diffuse (70%) and focal spasm (68%) with a good correlation between AVV and index of microcirculatory resistance (R = 0.353; p = 0.022). For a median follow-up of 1,043 days, focal spasm showed the worst prognosis (log rank p = 0.005), for which IPN was a significant prognostic factor. By contrast, diffuse spasm showed the greatest AVV with an intermediate prognosis. The prognostic value of INOCA was significantly enhanced by adding AVV and IPN to the physiological indices (area under the curve = 0.88 vs. 0.76; p = 0.048). CONCLUSIONS: These results provide the first evidence that there are important prognostic links between coronary morphologies (evaluated by optical coherence tomography) and coronary functional abnormalities in patients with INOCA, indicating the importance of both evaluations in this population.

  18. Assessment of coronary vasomotor responses to acetylcholine in German and Japanese patients with epicardial coronary spasm-more similarities than differences?

    Akira Suda, Andreas Seitz, Yuji Odaka, Anastasios Athanasiadis, Giancarlo Pirozzolo, Koichi Sato, Kiyotaka Hao, Raffi Bekeredjian, Jun Takahashi, Udo Sechtem, Hiroaki Shimokawa, Peter Ong

    Heart and vessels　36　(3)　337-344　2021/03

    DOI： 10.1007/s00380-020-01707-9 　

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    Coronary spasm is an established cause for angina pectoris. Ethnic differences have been suggested among Asian compared to Caucasian patients regarding prevalence, gender distribution, and angiographic patterns of coronary spasm. The aim of this study was to compare contemporary German and Japanese patients with coronary spasm. Between 2011 and 2015, 149 patients with resting angina and unobstructed coronary arteries with acetylcholine-induced epicardial spasm were enrolled in Stuttgart, Germany (n = 69) and Sendai, Japan (n = 80). All patients underwent intracoronary acetylcholine testing according to a standardized protocol. Comprehensive analysis included type of spasm (focal/diffuse), dose of acetylcholine leading to spasm, and frequency of multivessel spasm. Patients in this study were 61 ± 11 years old, predominantly female (54%), and had normal left ventricular ejection fraction (73 ± 9%). Diffuse spasm was the most prevalent type of spasm (85%) whereas focal spasm was found in the remaining 15% of patients. 31% of patients had multivessel spasm. Comparing the German with the Japanese patients, distribution of spasm type (focal/diffuse, p = 0.19) and frequency of multivessel spasm (p = 0.22) were comparable. Moreover, when Japanese patients were compared with German patients and diffuse spasm with focal spasm patients, respectively, no significant differences were observed regarding the acetylcholine dose required to induce spasm (p = 0.078 and p = 0.46, respectively). In conclusion, diffuse epicardial coronary spasm is the most frequent finding among German and Japanese patients with resting angina, unobstructed coronary arteries, and epicardial spasm on acetylcholine testing. Japanese and German patients share several similarities including comparable types of spasm and frequency of multivessel spasm.

  19. Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease. International-journal

    Kiyotaka Hao, Jun Takahashi, Yoku Kikuchi, Akira Suda, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Tomohiko Shindo, Kensuke Nishimiya, Shohei Ikeda, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

    Journal of the American Heart Association　10　(2)　e017831　2021/01/16

    DOI： 10.1161/JAHA.120.017831 　

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    BACKGROUND Stable coronary artery disease is caused by a variable combination of organic coronary stenosis and functional coronary abnormalities, such as coronary artery spasm. Thus, we examined the clinical importance of comorbid significant coronary stenosis and coronary spasm. METHODS AND RESULTS We enrolled 236 consecutive patients with suspected angina who underwent acetylcholine provocation testing for coronary spasm and fractional flow reserve (FFR) measurement. Among them, 175 patients were diagnosed as having vasospastic angina (VSA), whereas the remaining 61 had no VSA (non-VSA group). The patients with VSA were further divided into the following 3 groups based on angiography and FFR: no organic stenosis (≤50% luminal stenosis; VSA-alone group, n=110), insignificant stenosis of FFR>0.80 (high-FFR group, n=36), and significant stenosis of FFR≤0.80 (low-FFR group, n=29). The incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, urgent percutaneous coronary intervention, and hospitalization attributed to unstable angina was evaluated. All patients with VSA received calcium channel blockers, and 28 patients (95%) in the low-FFR group underwent a planned percutaneous coronary intervention. During a median follow-up period of 656 days, although the incidence of major adverse cardiovascular events was low and comparable among non-VSA, VSA-alone, and high-FFR groups, the low-FFR group had an extremely poor prognosis (non-VSA group, 1.6%; VSA-alone group, 3.6%; high-FFR group, 5.6%; low-FFR group, 27.6%) (P<0.001). Importantly, all 8 patients with major adverse cardiovascular events in the low-FFR group were appropriately treated with percutaneous coronary intervention and calcium channel blockers. CONCLUSIONS These results indicate that patients with VSA with significant coronary stenosis represent a high-risk population despite current guideline-recommended therapies, suggesting the importance of routine coronary functional testing in this population.

  20. Clinical profiles and outcomes in the treatment of acute myocardial infarction in Japan of aging society

    Makoto Suzuki, Kensaku Nishihira, Misa Takegami, Satoshi Honda, Sunao Kojima, Morimasa Takayama, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda, Takashi Takenaka, Daisuke Hotta, Tomonori Itoh, Tetsu Watanabe, Kiyotaka Hao, Kazuomi Kario, Takeshi Yamamoto, Naoki Sato, Atsuo Namiki, Hiroshi Suzuki, Masami Kosuge, Takashi Tanigawa, Yasuhide Asaumi, Kenichi Tsujita, Yoshihiro Miyamaoto

    Heart and Vessels　35　(12)　1681-1688　2020/12/01

    DOI： 10.1007/s00380-020-01654-5 　

    ISSN： 0910-8327

    eISSN： 1615-2573

  21. 生体吸収性ポリマーによる薬剤溶出性ステント留置後冠動脈過収縮反応の抑制効果 光干渉断層撮影法(OCT)を用いた臨床的検討

    光石 清人, 西宮 健介, 松本 泰治, 渡辺 翼, 土屋 聡, 杉澤 潤, 佐藤 公一, 須田 彬, 進藤 智彦, 神戸 茂雄, 池田 尚平, 羽尾 清貴, 菊地 翼, 高橋 潤, 下川 宏明

    脈管学　60　(Suppl.)　S127-S127　2020/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  22. 冠動脈閉塞を伴わない心筋梗塞(MINOCA)患者に関する検討 宮城県AMI登録研究

    羽尾 清貴, 高橋 潤, 佐藤 公一, 須田 彬, 進藤 智彦, 神戸 茂雄, 西宮 健介, 菊地 翼, 白戸 崇, 坂田 泰彦, 下川 宏明

    脈管学　60　(Suppl.)　S128-S128　2020/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  23. TAVIは重症大動脈弁狭窄症患者のBNP値の低下に伴う冠微小血管の拡張機能障害を改善する(TAVI Improves Impaired Vasodilator Capacity of Coronary Microvessels Associated with Decreased BNP Levels in Patients with Severe Aortic Stenosis)

    土屋 聡, 松本 泰治, 杉澤 潤, 佐藤 公一, 須田 彬, 進藤 智彦, 神戸 茂雄, 西宮 健介, 竹内 雅史, 菊地 翼, 羽尾 清貴, 高橋 潤, 熊谷 紀一郎, 齋木 佳克, 下川 宏明

    日本循環器学会学術集会抄録集　84回　PJ18-8　2020/07

    Publisher: (一社)日本循環器学会

  24. Marked Impairment of Endothelium-Dependent Digital Vasodilatations in Patients With Microvascular Angina: Evidence for Systemic Small Artery Disease. International-journal Peer-reviewed

    Shoko Ohura-Kajitani, Takashi Shiroto, Shigeo Godo, Yosuke Ikumi, Akiyo Ito, Shuhei Tanaka, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Kiyotaka Hao, Yoku Kikuchi, Kotaro Nochioka, Yasuharu Matsumoto, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa

    Arteriosclerosis, thrombosis, and vascular biology　40　(5)　ATVBAHA119313704-1412　2020/04/02

    DOI： 10.1161/ATVBAHA.119.313704 　

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    OBJECTIVE: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) and microvascular angina (MVA). We simultaneously examined endothelial functions of peripheral conduit and resistance arteries in patients with coronary functional disorders, with a special reference to NO and endothelium-dependent hyperpolarization factors. Approach and Results: Based on the results of invasive coronary acetylcholine testing and coronary physiological measurements, we divided 43 patients into 3 groups; VSA, MVA, and VSA+MVA. Endothelium-dependent vasodilatations of the brachial artery and fingertip arterioles to intra-arterial infusion of bradykinin were simultaneously evaluated by ultrasonography and peripheral arterial tonometry, respectively. To assess NO and endothelium-dependent hyperpolarization factors, measurements were repeated after oral aspirin and intra-arterial infusion of NG-monomethyl-L-arginine. Additionally, endothelium-independent vasodilatations to sublingual nitroglycerin and plasma levels of biomarkers for endothelial functions were measured. Surprisingly, digital vasodilatations to bradykinin were almost absent in patients with MVA alone and those with VSA+MVA compared with those with VSA alone. Mechanistically, both NO- and endothelium-dependent hyperpolarization-mediated digital vasodilatations were markedly impaired in patients with MVA alone. In contrast, endothelium-independent vasodilatations to nitroglycerin were comparable among the 3 groups. Plasma levels of soluble VCAM (vascular cell adhesion molecule)-1 were significantly higher in patients with MVA alone compared with those with VSA alone. CONCLUSIONS: These results provide the first evidence that both NO- and endothelium-dependent hyperpolarization-mediated digital vasodilatations are markedly impaired in MVA patients, suggesting that MVA is a cardiac manifestation of the systemic small artery disease.

  25. Usefulness of intracoronary administration of fasudil, a selective Rho-kinase inhibitor, for PCI-related refractory myocardial ischemia. International-journal Peer-reviewed

    Yoku Kikuchi, Jun Takahashi, Kiyotaka Hao, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    International journal of cardiology　297　8-13　2019/12/15

    DOI： 10.1016/j.ijcard.2019.09.057 　

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    BACKGROUND: Intra-procedural myocardial ischemia as an iatrogenic complication still remains a critical issue in contemporary interventional cardiology. The aim of this study was to examine the usefulness of fasudil, a selective Rho-kinase inhibitor, for percutaneous coronary intervention (PCI)-related myocardial ischemia. METHODS: Among 448 PCI sessions performed between October 2015 and December 2017, we retrospectively examined 36 patients (69.0 ± 9.1 [SD] yrs., M/F 26/10) who underwent intracoronary administration of fasudil during a procedure to resolve myocardial ischemia that was resistant to intracoronary nitrate administration. RESULTS: The refractory myocardial ischemia was caused by distal embolization (69%), enhanced vasoconstriction at distal site of chronic total occlusion (11%), coronary spasm (11%), and coronary dissection (8%), most of which occurred immediately after balloon or stent dilatation. Intracoronary fasudil significantly improved corrected TIMI frame count (from 37 [30-56] to 24 [12-36]) and TIMI flow grade (from 2 [1-2.5] to 3 [2-3]) (both P < 0.001). Finally, 86% of all subjects successfully obtained TIMI flow grade 3 at the end of the procedure. Intracoronary fasudil tended to be more effective in patients with an attenuated plaque detected by intravascular ultrasound. Importantly, among the 19 elective cases, fasudil successfully prevented 17 patients from developing post-procedure myocardial infarction. Although fasudil-induced transient hypotension requiring a vasopressor was noted in 22% of the subjects, no other adverse effects were noted. CONCLUSIONS: These results indicate that fasudil is a useful and safe therapeutic option for PCI-related myocardial ischemia refractory intracoronary nitrate.

  26. Coronary Functional Abnormalities in Patients With Angina and Nonobstructive Coronary Artery Disease. International-journal Peer-reviewed

    Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    Journal of the American College of Cardiology　74　(19)　2350-2360　2019/11/12

    DOI： 10.1016/j.jacc.2019.08.1056 　

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    BACKGROUND: Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary stenosis, in whom coronary functional abnormalities could be involved. OBJECTIVES: This study examined the significance of coronary functional abnormalities in a comprehensive manner for both epicardial and microvascular coronary arteries in patients with angina and nonobstructive coronary artery disease (CAD). METHODS: This study prospectively enrolled 187 consecutive patients (male/female 113/74, 63.2 ± 12.3 years), who underwent acetylcholine provocation test for coronary spasm and measurement of index of microcirculatory resistance (IMR) to evaluate coronary microvascular function, and followed them for a median of 893 days. RESULTS: Of all subjects, acetylcholine test identified 128 patients with vasospastic angina (VSA) (68%), and cardiac events occurred in 10 patients (5.3%) during the follow-up. Multivariable analysis revealed that IMR correlated with the incidence of cardiac events (hazard ratio: 1.05; 95% confidence interval: 1.02 to 1.09; p = 0.002) and receiver-operating characteristics (ROC) curve analysis identified IMR of 18.0 as the optimal cut-off value. Among the 4 groups based on the cut-off value of IMR and the presence of VSA, the Kaplan-Meier survival analysis showed a significantly worse prognosis in the group with high IMR (≥18.0) and VSA compared with other groups (log rank, p = 0.002). Importantly, intracoronary administration of fasudil, a Rho-kinase inhibitor, significantly ameliorated IMR in the VSA patients with increased IMR (p < 0.0001). CONCLUSIONS: These results indicate that in patients with angina and nonobstructive CAD, coexistence of epicardial coronary spasm and increased microvascular resistance is associated with worse prognosis, for which Rho-kinase activation may be involved.

  27. Temporal trends in the prevalence and outcomes of geriatric patients with acute myocardial infarction in Japan-A report from the Miyagi AMI Registry Study. International-journal Peer-reviewed

    Koichi Sato, Jun Takahashi, Kiyotaka Hao, Satoshi Miyata, Akira Suda, Tomohiko Shindo, Shohei Ikeda, Yoku Kikuchi, Takashi Shiroto, Yasuharu Matsumoto, Yasuhiko Sakata, Hiroaki Shimokawa

    Journal of cardiology　75　(5)　465-472　2019/11/12

    DOI： 10.1016/j.jjcc.2019.10.006 　

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    BACKGROUND: Along with the global aging, the number of geriatric patients with acute myocardial infarction (AMI) has been increasing. However, temporal trends in the prevalence and outcomes of geriatric patients with AMI, with a special reference to heart failure (HF) on admission, remain to be elucidated. METHODS: The Miyagi AMI Registry is a prospective, multicenter, and observational study. This registry was established in 1979 and has been continued for 40 years. We examined a total of 6,596 AMI patients aged ≥70 years (male/female 4,141/2,455) registered in this registry from 2005 to 2016 and divided them into 3 groups according to age [70-79 (n = 3,485), 80-89 (n = 2,601), and ≥90 years (n = 510)]. RESULTS: Of those, 17.6% had HF (Killip class ≥ II) on admission, for which age, female sex, diabetes, and previous MI were identified as independent predictors. Importantly, the prevalence of HF on admission significantly increased in all ages during the study period (all p for trend <0.01). Despite the presence of HF on admission, primary percutaneous coronary intervention (PCI) was performed in about 70% of patients aged in their 80 s and about half of those aged ≥90 years. In each group, performance rate of primary PCI also progressively increased (all p < 0.05) irrespective of concomitant HF. However, in-hospital mortality remained unchanged. Multivariable analysis demonstrated that, even for patients with HF on admission, primary PCI was associated with improved in-hospital mortality in the younger 2 groups [adjusted odds ratios (ORs), 95% confidence intervals (CI) 0.58 (0.36-0.93) for 70s, 0.64 (0.43-0.95) for 80s, and 0.99 (0.44-2.21) for ≥90s], whereas PCI was ineffective to reduce long-term hospitalization ≥30 days in all groups [adjusted ORs (95%CI) 0.90 (0.52-1.54), 0.66 (0.38-1.14), and 0.38 (0.07-2.10)]. CONCLUSIONS: These results demonstrate that increasing prevalence of HF on admission and increasing performance of primary PCI counteract each other with resultant unchanged in-hospital outcomes in geriatric AMI patients in Japan.

  28. 非閉塞性冠動脈疾患における冠動脈機能異常の包括的評価 Peer-reviewed

    須田 彬, 高橋 潤, 羽尾 清貴, 菊地 翼, 進藤 智彦, 佐藤 公一, 杉澤 潤, 松本 泰治, 宮田 敏, 坂田 泰彦, 下川 宏明

    脈管学　59　(Suppl.)　S168-S169　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  29. 高齢大動脈弁狭窄症患者に対する経カテーテル大動脈弁置換術は認知機能を改善する 脳血流改善の意義

    土屋 聡, 松本 泰治, 鈴木 秀明, 杉澤 潤, 須田 彰, 佐藤 公一, 進藤 智彦, 池田 尚平, 菊地 翼, 西宮 健介, 羽尾 清貴, 高橋 潤, 斎木 佳克, 下川 宏明

    日本心血管インターベンション治療学会抄録集　28回　[MO164-004]　2019/09

    Publisher: (一社)日本心血管インターベンション治療学会

  30. PCI時代における冠動脈機能異常の重要性 胸痛を有する非閉塞性冠動脈疾患患者における冠動脈機能異常に関する包括的評価

    須田 彬, 高橋 潤, 羽尾 清貴, 菊地 翼, 進藤 智彦, 池田 尚平, 佐藤 公一, 杉澤 潤, 松本 泰治, 宮田 敏, 坂田 泰彦, 下川 宏明

    日本心血管インターベンション治療学会抄録集　28回　[S28-2]　2019/09

    Publisher: (一社)日本心血管インターベンション治療学会

  31. Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature. Peer-reviewed

    Tsuchiya S, Matsumoto Y, Doman T, Fujiya T, Sugisawa J, Suda A, Sato K, Ikeda S, Shindo T, Kikuchi Y, Hao K, Takahashi J, Hatta W, Koike T, Masamune A, Saiki Y, Horiuchi H, Shimokawa H

    Journal of atherosclerosis and thrombosis　27　(3)　271-277　2019/08

    DOI： 10.5551/jat.49239 　

    ISSN： 1340-3478

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    An 83-year-old woman with severe aortic stenosis was admitted to our hospital due to heart failure with refractory anemia requiring blood transfusions. She had repetitive bleeding episodes from endoscopically proven angiodysplasia in the stomach. Moreover, she repeatedly underwent endoscopic argon plasma coagulation for hemostasis. Importantly, she had a deficiency of the high-molecular-weight (HMW) multimers of von Willebrand factor (VWF), and she was diagnosed with Heyde's syndrome.After she underwent transcatheter aortic valve implantation (TAVI), aortic valve area and mean left ventricular aorta pressure gradient improved. Notably, endoscopy showed cessation of bleeding at 10 days after TAVI and the disappearance of angiodysplasia at 4 months after TAVI. Even at 2 years after TAVI, follow-up endoscopy showed remaining free of angiodysplasia in the stomach. She experienced no episodes of anemia since TAVI procedure. Additionally, analysis of HMW multimers demonstrated immediate and lasting recovery after TAVI.Recovery of HMW multimers of VWF with cessation of gastrointestinal bleeding following aortic valve replacement has been previously reported in a patient diagnosed with Heyde's syndrome. To the best our knowledge, this is the first case to demonstrate that angiodysplasia disappears after TAVI for a long term with endoscopic images in a patient with Heyde's syndrome. Here, we summarized case reports of patients with Heyde's syndrome that required aortic valve intervention. Cessation of gastrointestinal bleeding and anemia after aortic valve intervention for severe aortic stenosis may be attributed not only to recovery of HMW multimers of VWF but also to the disappearance of angiodysplasia.

  32. Prognostic impact of residual stenosis after percutaneous coronary intervention in patients with ischemic heart failure - A report from the CHART-2 study. International-journal Peer-reviewed

    Kiyotaka Hao, Jun Takahashi, Yasuhiko Sakata, Satoshi Miyata, Takashi Shiroto, Kotaro Nochioka, Masanobu Miura, Takuya Oikawa, Ruri Abe, Masayuki Sato, Shintaro Kasahara, Hajime Aoyanagi, Hiroaki Shimokawa

    International journal of cardiology　278　22-27　2019/03/01

    DOI： 10.1016/j.ijcard.2018.10.062 　

    ISSN： 0167-5273

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    BACKGROUND: Complete revascularization with PCI is not always achieved in patients with ischemic HF. Therefore, this study aimed to elucidate the prognostic impact of residual coronary stenosis (RS) after percutaneous coronary intervention (PCI) in patients with ischemic heart failure (HF). METHODS: We analyzed a total of 1307 patients with symptomatic HF and a history of PCI registered in our Chronic Heart Failure Analysis and Registry in the Tohoku District-2 (CHART-2) Study. RS that was defined as the presence of ≥70% luminal stenosis in major coronary arteries at the last coronary angiography. RESULTS: Among the study population, 851 patients (65.1%) had RS. During a median follow-up period of 3.2 years, patients with RS had higher all-cause mortality than those without it even after propensity score matching (21.9 vs. 11.6%, log-rank P = 0.027). Multivariable Cox hazard analysis also showed the negative impact of RS on all-cause death in ischemic HF patients [hazard ratio (HR):1.62, 95% confidence interval (CI): 1.07-2.46, P = 0.024]. Importantly, when divided all subjects into three subgroups by left ventricular ejection fraction (LVEF) [LVEF < 40% (HFrEF), LVEF 40-49% (HFmrEF), and LVEF ≥ 50% (HFpEF)], inverse probability of treatment weighted method provided a similar result that RS after PCI was an independent risk factor for death in the HFpEF [HR(95%CI); 1.94(1.22-3.09), P < 0.01] and HFmrEF [4.47(1.13-14.98), P < 0.01] groups, but not in the HFrEF group [1.20(0.59-2.43), P = 0.62]. CONCLUSIONS: These results indicate that RS after PCI could aggravate long-term prognosis of ischemic HF patients with moderate- to well-preserved EF, but not those with reduced EF.

  33. A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan. Peer-reviewed

    Yoku Kikuchi, Kenta Ito, Tomohiko Shindo, Kiyotaka Hao, Takashi Shiroto, Yasuharu Matsumoto, Jun Takahashi, Takao Matsubara, Akira Yamada, Yukio Ozaki, Michiaki Hiroe, Kazuo Misumi, Hideki Ota, Kentaro Takanami, Tomomichi Hiraide, Kei Takase, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji, Hiroaki Shimokawa

    Heart and vessels　34　(1)　104-113　2019/01

    DOI： 10.1007/s00380-018-1215-4 　

    ISSN： 0910-8327

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    We have previously demonstrated that cardiac shock wave therapy (CSWT) effectively improves myocardial ischemia through coronary neovascularization both in a porcine model of chronic myocardial ischemia and in patients with refractory angina pectoris (AP). In this study, we further addressed the efficacy and safety of CSWT in a single-arm multicenter study approved as a highly advanced medical treatment by the Japanese Ministry of Health, Labour and Welfare. Fifty patients with refractory AP [mean age 70.9 ± 12.6 (SD) years, M/F 38/12] without the indications of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were enrolled in 4 institutes in Japan. Ischemic myocardial regions in the left ventricle (LV) were identified by drug-induced stress myocardial perfusion imaging (MPI). Shock waves (200 shots/spot at 0.09 mJ/mm2) were applied to 40-60 spots in the ischemic myocardium 3 times in the first week. The patients were followed up for 3 months thereafter. Forty-one patients underwent CSWT and completed the follow-up at 3 months. CSWT markedly improved weekly nitroglycerin use [from 3.5 (IQR 2 to 6) to 0 (IQR 0 to 1)] and the symptoms [Canadian Cardiovascular Society functional class score, from 2 (IQR 2 to 3) to 1 (IQR 1 to 2)] (both P < 0.001). CSWT also significantly improved 6-min walking distance (from 384 ± 91 to 435 ± 122 m, P < 0.05). There were no significant changes in LV ejection fraction evaluated by echocardiography and LV stroke volume evaluated by cardiac magnetic resonance imaging (from 56.3 ± 14.7 to 58.8 ± 12.8%, P = 0.10, and from 52.3 ± 17.4 to 55.6 ± 15.7 mL, P = 0.15, respectively). Percent myocardium ischemia assessed by drug-induced stress MPI tended to be improved only in the treated segments (from 16.0 ± 11.1 to 12.1 ± 16.2%, P = 0.06), although no change was noted in the whole LV. No procedural complications or adverse effects related to the CSWT were noted. These results of the multicenter trial further indicate that CSWT is a useful and safe non-invasive strategy for patients with refractory AP with no options of PCI or CABG.

  34. PCI関連心筋虚血に対する選択的Rho-kinase阻害薬ファスジルの冠動脈内投与の有効性

    菊地 翼, 高橋 潤, 佐藤 公一, 杉澤 潤, 土屋 聡, 須田 彬, 進藤 智彦, 池田 尚平, 羽尾 清貴, 白戸 崇, 松本 泰治, 坂田 泰彦, 下川 宏明

    日本心血管インターベンション治療学会抄録集　27回　MO005-MO005　2018/08

    Publisher: (一社)日本心血管インターベンション治療学会

  35. 心不全患者における冠動脈インターベンション後の残存狭窄が予後に及ぼす影響 Peer-reviewed

    羽尾 清貴, 高橋 潤, 坂田 泰彦, 宮田 敏, 白戸 崇, 後岡 広太郎, 三浦 正暢, 下川 宏明

    日本心血管インターベンション治療学会抄録集　27回　MO066-MO066　2018/08

    Publisher: (一社)日本心血管インターベンション治療学会

  36. Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: a first-in-human study. International-journal Peer-reviewed

    Yuta Kagaya, Kenta Ito, Jun Takahashi, Yasuharu Matsumoto, Takashi Shiroto, Ryuji Tsuburaya, Yoku Kikuchi, Kiyotaka Hao, Kensuke Nishimiya, Tomohiko Shindo, Tsuyoshi Ogata, Ryo Kurosawa, Kumiko Eguchi, Yuto Monma, Sadamitsu Ichijo, Kazuaki Hatanaka, Satoshi Miyata, Hiroaki Shimokawa

    Coronary artery disease　29　(4)　294-300　2018/06

    DOI： 10.1097/MCA.0000000000000577 　

    ISSN： 0954-6928

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    OBJECTIVE: Although primary percutaneous coronary intervention (PCI) substantially reduces the mortality of patients with acute myocardial infarction (AMI), left ventricular (LV) remodeling after AMI still remains an important issue in cardiovascular medicine. We have previously demonstrated that low-energy cardiac shockwave (SW) therapy ameliorates LV remodeling after AMI in pigs. In this first-in-human study, we examined the feasibility and the effects of the SW therapy on LV remodeling after AMI in humans. PATIENTS AND METHODS: Seventeen patients with AMI who successfully underwent primary PCI (peak-creatine kinase<4000 U/l) were treated with the SW therapy. Low-energy shock waves were applied to the ischemic border zone around the infarcted area at 2, 4, and 6 days since AMI. Next, we compared these patients with historical AMI controls by propensity score matching (N=25). RESULTS: There were no procedure-related complications or adverse effects. At 6 and 12 months after AMI, LV function as assessed by MRI showed no signs of deleterious LV remodeling. When we compared the SW-treated group with the historical AMI controls at 6 months after AMI, LV ejection fraction was significantly higher in the SW-treated group (N=7) than in the historical control group (N=25) by echocardiography (66±7 vs. 58±12%, P<0.05). LV end-diastolic dimension also tended to be smaller in the SW than in the control group (47.5±4.6 vs. 50.0±5.9 mm, P=0.29). CONCLUSION: These results suggest that low-energy extracorporeal cardiac SW therapy is feasible and may ameliorate postmyocardial infarction LV remodeling in patients with AMI as an adjunctive therapy to primary PCI.

  37. Prognostic impacts of Rho-kinase activity in circulating leucocytes in patients with vasospastic angina. International-journal Peer-reviewed

    Taro Nihei, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Yuji Odaka, Ryuji Tsuburaya, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    European heart journal　39　(11)　952-959　2018/03/14

    DOI： 10.1093/eurheartj/ehx657 　

    ISSN： 0195-668X

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    Aims: Rho-kinase activity in circulating leucocytes is a useful biomarker for diagnosis and disease activity assessment of vasospastic angina (VSA). The present study aimed to examine the long-term prognostic impact of Rho-kinase activity in circulating leucocytes in VSA patients. Methods and results: We prospectively enrolled 174 consecutive patients with VSA and 50 non-VSA patients, in whom we measured Rho-kinase activity in circulating leucocytes, and they were followed for a median of 16 months. The primary endpoint was cardiac events including cardiac death, non-fatal myocardial infarction, and hospitalization for unstable angina. During the follow-up period, cardiac events occurred in 10 VSA patients (5.7%) but in none of the non-VSA patients. When we divided VSA patients into two groups by a median value of their Rho-kinase activity, the Kaplan-Meier survival analysis showed a significantly worse prognosis in VSA patients with high Rho-kinase activity compared with those with low activity or non-VSA patients (log-rank; P < 0.05, respectively). Receiver-operating characteristic curve analysis showed that Rho-kinase activity value of 1.24 was the best cut-off level to predict cardiac events in VSA patients, and multivariable analysis showed that a value above the cut-off point had the largest hazard ratio to predict poor outcome in VSA patients [hazard ratio (95% confidence interval) 11.19 (1.41-88.95); P = 0.022]. Importantly, combination of the Japanese Coronary Spasm Association risk score and Rho-kinase activity significantly improved the prognostic impact in VSA patients as compared with either alone. Conclusion: Rho-kinase activity in circulating leucocytes is useful for prognostic stratification of VSA patients.

  38. Coronary Adventitial and Perivascular Adipose Tissue Inflammation in Patients With Vasospastic Angina. International-journal Peer-reviewed

    Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Hiroaki Shimokawa

    Journal of the American College of Cardiology　71　(4)　414-425　2018/01/30

    DOI： 10.1016/j.jacc.2017.11.046 　

    ISSN： 0735-1097

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    BACKGROUND: Recent studies suggested that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play an important role as a source of various inflammatory mediators in cardiovascular disease. OBJECTIVES: The authors tested their hypothesis that coronary artery spasm is associated with perivascular inflammation in patients with vasospastic angina (VSA) using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). METHODS: This study prospectively examined 27 consecutive VSA patients with acetylcholine-induced diffuse spasm in the left anterior descending artery (LAD) and 13 subjects with suspected angina but without organic coronary lesions or coronary spasm. Using CT coronary angiography and electrocardiogram-gated 18F-FDG PET/CT, coronary PVAT volume and coronary perivascular FDG uptake in the LAD were examined. In addition, adventitial VV formation in the LAD was examined with optical coherence tomography, and Rho-kinase activity was measured in circulating leukocytes. RESULTS: Patient characteristics were comparable between the 2 groups. CT coronary angiography and ECG-gated 18F-FDG PET/CT showed that coronary PVAT volume and coronary perivascular FDG uptake significantly increased in the VSA group compared with the non-VSA group. Furthermore, optical coherence tomography showed that adventitial VV formation significantly increased in the VSA group compared with the non-VSA group, as did Rho-kinase activity. Importantly, during the follow-up period with medical treatment, both coronary perivascular FDG uptake and Rho-kinase activity significantly decreased in the VSA group. CONCLUSIONS: These results provide the first evidence that coronary spasm is associated with inflammation of coronary adventitia and PVAT, where 18F-FDG PET/CT could be useful for disease activity assessment. (Morphological and Functional Change of Coronary Perivascular Adipose Tissue in Vasospastic Angina [ADIPO-VSA Trial]; UMIN000016675).

  39. Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study Peer-reviewed

    Kensuke Nishimiya, Yasuharu Matsumoto, Hongxin Wang, Zhonglie Piao, Kazuma Ohyama, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY　250　275-277　2018/01

    DOI： 10.1016/j.ijcard.2017.09.211 　

    ISSN： 0167-5273

    eISSN： 1874-1754

  40. European Society of Cardiology (ESC) Annual Congress Report From Barcelona 2017 Peer-reviewed

    Kimio Satoh, Jun Takahashi, Yasuharu Matsumoto, Shunsuke Tatebe, Tatsuo Aoki, Yoku Kikuchi, Kiyotaka Hao, Kazuma Ohyama, Masamichi Nogi, Akira Suda, Shintaro Kasahara, Koichi Sato, Sadamitsu Ichijo, Hiroaki Shimokawa

    CIRCULATION JOURNAL　81　(12)　1758-1763　2017/12

    DOI： 10.1253/circj.CJ-17-1103 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  41. Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney-Brain-Heart Axis. International-journal Peer-reviewed

    Hironori Uzuka, Yasuharu Matsumoto, Kensuke Nishimiya, Kazuma Ohyama, Hideaki Suzuki, Hirokazu Amamizu, Susumu Morosawa, Michinori Hirano, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Kenta Ito, Jun Takahashi, Koji Fukuda, Satoshi Miyata, Yoshihito Funaki, Hatsue Ishibashi-Ueda, Satoshi Yasuda, Hiroaki Shimokawa

    Arteriosclerosis, thrombosis, and vascular biology　37　(10)　1869-1880　2017/10

    DOI： 10.1161/ATVBAHA.117.309777 　

    ISSN： 1079-5642

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    OBJECTIVE: Drug-eluting stent-induced coronary hyperconstricting responses remain an important issue. The adventitia harbors a variety of components that potently modulate vascular tone, including sympathetic nerve fibers (SNF) and vasa vasorum. Catheter-based renal denervation (RDN) inhibits sympathetic nerve activity. We, thus, examined whether RDN suppresses drug-eluting stent-induced coronary hyperconstricting responses, and if so, what mechanisms are involved. APPROACH AND RESULTS: Protocol 1: pigs implanted with everolimus-eluting stents into the left coronary arteries underwent coronary angiography at 1 month after implantation for assessment of coronary vasomotion and adventitial SNF formation. Drug-eluting stent-induced coronary hyperconstricting responses were significantly enhanced associated with enhanced coronary adventitial SNF and vasa vasorum formation. Protocol 2: pigs implanted with everolimus-eluting stents were randomly assigned to the RDN or sham group. The RDN group underwent renal ablation. At 1 month, RDN significantly caused marked damage of the SNF at the renal arteries without any stenosis, thrombus, or dissections. Notably, RDN significantly upregulated the expression of α2-adrenergic receptor-binding sites in the nucleus tractus solitarius, attenuated muscle sympathetic nerve activity, and decreased systolic blood pressure and plasma renin activity. In addition, RDN attenuated coronary hyperconstricting responses to intracoronary serotonin at the proximal and distal stent edges associated with decreases in SNF and vasa vasorum formation, inflammatory cell infiltration, and Rho-kinase expression/activation. Furthermore, there were significant positive correlations between SNF and vasa vasorum and between SNF and coronary vasoconstricting responses. CONCLUSIONS: These results provide the first evidence that RDN ameliorates drug-eluting stent-induced coronary hyperconstricting responses in pigs in vivo through the kidney-brain-heart axis.

  42. Age-Specific Trends in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction Over 30 Years in Japan - Report From the Miyagi AMI Registry Study. Peer-reviewed

    Yuanji Cui, Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Tomohiko Shindo, Kensuke Nishimiya, Yoku Kikuchi, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　81　(4)　520-528　2017/03/24

    DOI： 10.1253/circj.CJ-16-0799 　

    ISSN： 1346-9843

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    BACKGROUND: We are now facing rapid population aging in Japan, which will affect the actual situation of cardiovascular diseases. However, age-specific trends in the incidence and mortality of acute myocardial infarction (AMI) in Japan remain to be elucidated.Methods and Results:We enrolled a total of 27,220 AMI patients (male/female 19,818/7,402) in our Miyagi AMI Registry during the past 30 years. We divided them into 4 age groups (≤59, 60-69, 70-79 and ≥80 years) and examined the temporal trends in the incidence and in-hospital mortality of AMI during 3 decades (1985-1994, 1995-2004 and 2005-2014). Throughout the entire period, the incidence of AMI steadily increased in the younger group (≤59 years in both sexes), while in the elderly groups (≥70 years in both sexes), the incidence significantly decreased during the last decade (all P<0.01). In-hospital cardiac mortality significantly decreased during the first 2 decades in elderly groups of both sexes (all P<0.01), whereas no further improvement was noted in the last decade irrespective of age or sex, despite improved critical care of AMI. CONCLUSIONS: These results provide the novel findings that the incidence of AMI has been increasing in younger populations and decreasing in the elderly, and that improvement in the in-hospital mortality of AMI may have reached a plateau in all age groups in Japan.

  43. 心臓リハビリテーションにおける心理、認知機能への対応 心不全患者の日常生活における問題点とリハビリ介入のありかたについて

    齊藤 夕貴, 羽尾 清貴, 長谷部 雄飛, 青木 竜男, 杉村 宏一郎, 梶川 アユミ, 明珍 千恵, 黒澤 桂子, 秋月 三奈, 柿花 隆昭, 下川 宏明

    日本循環器学会学術集会抄録集　81回　CS1-3　2017/03

    Publisher: (一社)日本循環器学会

  44. 微小血管性狭心症患者におけるnitrate投与後も持続する心筋虚血(Sustained Myocardial Ischemia in Patients with Microvascular Angina Even after Nitrate Administration) Peer-reviewed

    小鷹 悠二, 高橋 潤, 羽尾 清貴, 菊地 翼, 須田 彬, 小松 真恭, 松本 泰治, 伊藤 健太, 宮田 敏, 坂田 泰彦, 下川 宏明

    日本循環器学会学術集会抄録集　81回　OJ-091　2017/03

    Publisher: (一社)日本循環器学会

  45. 日本の高齢急性心筋梗塞患者における救急治療の経時的な傾向と転帰(Temporal Trends in Emergency Care and Outcomes of Geriatric Patients with Acute Myocardial Infarction in Japan) Peer-reviewed

    崔 元吉, 羽尾 清貴, 高橋 潤, 宮田 敏, 進藤 智彦, 菊地 翼, 松本 泰治, 伊藤 健太, 坂田 泰彦, 下川 宏明

    日本循環器学会学術集会抄録集　81回　PJ-290　2017/03

    Publisher: (一社)日本循環器学会

  46. 血管攣縮性狭心症を有する院外心停止後生存者の長期予後 更新情報(Long-term Prognosis of Out-of-hospital Cardiac Arrest Survivors with Vasospastic Angina: An Update) Peer-reviewed

    小松 真恭, 高橋 潤, 羽尾 清貴, 菊地 翼, 小鷹 悠二, 須田 彬, 松本 泰治, 坂田 泰彦, 宮田 敏, 下川 宏明

    日本循環器学会学術集会抄録集　81回　PJ-673　2017/03

    Publisher: (一社)日本循環器学会

  47. Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries. International-journal Peer-reviewed

    Yuji Odaka, Jun Takahashi, Ryuji Tsuburaya, Kensuke Nishimiya, Kiyotaka Hao, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Satoshi Miyata, Daisuke Manita, Yuji Hirowatari, Hiroaki Shimokawa

    European heart journal　38　(7)　489-496　2017/02/14

    DOI： 10.1093/eurheartj/ehw448 　

    ISSN： 0195-668X

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    Aims: Although the importance of coronary microvascular dysfunction (CMD) has been emerging, reliable biomarkers for CMD remain to be developed. We examined the potential usefulness of plasma concentration of serotonin to diagnose CMD in patients with suspected angina and unobstructive coronary arteries. Methods and results: We enrolled 198 consecutive patients (M/F 116/82, 60.2 ± 13.3 years old) who underwent acetylcholine provocation test and measured plasma serotonin concentration. Coronary microvascular dysfunction was defined as myocardial lactate production without or prior to the occurrence of epicardial coronary spasm during acetylcholine provocation test. Although no statistical difference in plasma concentration of serotonin [median (inter-quartile range) nmol/L] was noted between the vasospastic angina (VSA) and non-VSA groups [6.8 (3.8, 10.9) vs. 5.1 (3.7, 8.4), P = 0.135], it was significantly higher in patients with CMD compared with those without it [7.7 (4.5, 14.2) vs. 5.6 (3.7, 9.3), P = 0.008]. Among the four groups classified according to the presence or absence of VSA and CMD, serotonin concentration was highest in the VSA with CMD group. Importantly, there was a positive correlation between plasma serotonin concentration and baseline thrombolysis in myocardial infarction frame count (P = 0.001), a marker of coronary vascular resistance. The classification and regression trees analysis showed that plasma serotonin concentration of 9.55 nmol/L was the first discriminator to stratify the risk for the presence of CMD. In multivariable analysis, serotonin concentration greater than the cut-off value had the largest odds ratio in the prediction of CMD [odds ratio (95% confidence interval) 2.63 (1.28-5.49), P = 0.009]. Conclusions: Plasma concentration of serotonin may be a novel biomarker for CMD in patients with angina and unobstructive coronary arteries.

  48. 東日本大震災と心血管病 Peer-reviewed

    青木 竜男, 中野 誠, 二瓶 太郎, 羽尾 清貴, 小野瀬 剛生, 杉村 宏一郎, 高橋 潤, 福田 浩二, 宮田 敏, 坂田 泰彦, 下川 宏明

    日本冠疾患学会雑誌　(Suppl.)　173-173　2016/12

    Publisher: (NPO)日本冠疾患学会

    ISSN： 1341-7703

    eISSN： 2187-1949

  49. Multiple sclerosis lesion in the medulla oblongata in a patient with takotsubo cardiomyopathy Peer-reviewed

    Katsuya Kozu, Hideaki Suzuki, Shuhei Nishiyama, Nobuhiro Yaoita, Saori Yamamoto, Shunsuke Tatebe, Masanobu Miura, Tatsuo Aoki, Kiyotaka Hao, Yasuharu Matsumoto, Koichiro Sugimura, Masashi Aoki, Hiroaki Shimokawa

    INTERNATIONAL JOURNAL OF CARDIOLOGY　222　980-981　2016/11

    DOI： 10.1016/j.ijcard.2016.08.128 　

    ISSN： 0167-5273

    eISSN： 1874-1754

  50. Focal Vasa Vasorum Formation in Patients With Focal Coronary Vasospasm - An Optical Frequency Domain Imaging Study Peer-reviewed

    Kensuke Nishimiya, Yasuharu Matsumoto, Hironori Uzuka, Kazuma Ohyama, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION JOURNAL　80　(10)　2252-+　2016/10

    DOI： 10.1253/circj.CJ-16-0580 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  51. 東日本大震災から学んだこと Peer-reviewed

    青木 竜男, 中野 誠, 二瓶 太郎, 羽尾 清貴, 小野瀬 剛生, 杉村 宏一郎, 高橋 潤, 福田 浩二, 宮田 敏, 坂田 泰彦, 下川 宏明

    日本心臓病学会学術集会抄録　64回　SS9-2　2016/09

    Publisher: (一社)日本心臓病学会

  52. Usefulness of Testing for Coronary Artery Spasm and Programmed Ventricular Stimulation in Survivors of Out-of-Hospital Cardiac Arrest. International-journal Peer-reviewed

    Masayasu Komatsu, Jun Takahashi, Koji Fukuda, Yusuke Takagi, Takashi Shiroto, Makoto Nakano, Masateru Kondo, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Satoshi Miyata, Hiroaki Shimokawa

    Circulation. Arrhythmia and electrophysiology　9　(9)　2016/09

    DOI： 10.1161/CIRCEP.115.003798 　

    ISSN： 1941-3149

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    BACKGROUND: Optimal therapy for patients resuscitated from out-of-hospital cardiac arrest (OHCA) who are not found to have structural heart disease remains to be established, especially regarding the use of implantable cardioverter-defibrillators. Coronary artery spasm (CAS) and lethal ventricular arrhythmias are important causes of OHCA. METHODS AND RESULTS: In 47 consecutive OHCA survivors without structural heart disease who had fully recovered (M/F 44/3, 43±13 years.), we performed dual induction tests, including acetylcholine provocation test first followed by programmed ventricular stimulation after 1 to 2 weeks. Patients with CAS were treated with calcium channel blocker-based antianginal medications; implantable cardioverter-defibrillators were implanted in all patients. The results of the dual induction tests defined 4 groups: CAS alone (n=7), inducible ventricular arrhythmias alone (n=13), both positive (n=24), and both negative (n=3). During a median follow-up period of 38 months, ventricular fibrillation recurred in all groups except the both-negative group. Of the 16 patients with a type I Brugada ECG, 2 had CAS alone, 8 had ventricular arrhythmias alone, and 6 had both positive. No ventricular fibrillation episodes were observed in the CAS-alone patients who did not also have Brugada syndrome. Kaplan-Meier analysis showed that the CAS-alone group was at lower risk for OHCA recurrence as compared with the Brugada syndrome group (log-rank test; P=0.036). CONCLUSIONS: Among OHCA survivors without structural heart disease, provokable CAS and ventricular arrhythmias are common and can be seen in Brugada syndrome. CAS alone without Brugada syndrome who are treated for CAS may be a lower-risk group.

  53. Overview of the 80th Annual Scientific Meeting of the Japanese Circulation Society - The Past, Present and Future of Cardiovascular Medicine in Japan - The 5th Anniversary of the Great East Japan Earthquake Peer-reviewed

    Jun Takahashi, Kimio Satoh, Koji Fukuda, Koichiro Sugimura, Yasuharu Matsumoto, Ryuji Tsuburaya, Tatsuo Aoki, Kensuke Nishimiya, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION JOURNAL　80　(8)　1689-1694　2016/08

    DOI： 10.1253/circj.CJ-16-0644 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  54. Increased Coronary Perivascular Adipose Tissue Volume in Patients With Vasospastic Angina Peer-reviewed

    Kazuma Ohyama, Yasuharu Matsumoto, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Hideki Ota, Hirokazu Amamizu, Hironori Uzuka, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION JOURNAL　80　(7)　1653-+　2016/07

    DOI： 10.1253/circj.CJ-16-0213 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  55. Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina: Assessment With OFDI. International-journal Peer-reviewed

    Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Hironori Uzuka, Hongxin Wang, Ryuji Tsuburaya, Kiyotaka Hao, Kazuma Ohyama, Yuji Odaka, Satoshi Miyata, Kenta Ito, Hiroaki Shimokawa

    Journal of the American College of Cardiology　67　(5)　598-600　2016/02/09

    DOI： 10.1016/j.jacc.2015.11.031 　

    ISSN： 0735-1097

  56. 震災と心血管病 東日本大震災に関する検討から

    青木 竜男, 杉村 宏一郎, 中野 誠, 羽尾 清貴, 二瓶 太郎, 小野瀬 剛生, 高橋 潤, 福田 浩二, 坂田 泰彦, 下川 宏明

    Japanese Journal of Disaster Medicine　20　(3)　444-444　2016/02

    Publisher: (一社)日本災害医学会

    ISSN： 2189-4035

  57. Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans - a validation study - . Peer-reviewed

    Kensuke Nishimiya, Yasuharu Matsumoto, Hironori Uzuka, Kazuma Oyama, Atsushi Tanaka, Akira Taruya, Tsuyoshi Ogata, Michinori Hirano, Tomohiko Shindo, Kenichiro Hanawa, Yuhi Hasebe, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Satoshi Miyata, Kenta Ito, Takashi Akasaka, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　79　(6)　1323-31　2015

    DOI： 10.1253/circj.CJ-15-0078 　

    ISSN： 1346-9843

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    BACKGROUND: Coronary adventitia harbors a wide variety of components, such as inflammatory cells and vasa vasorum (VV). Adventitial VV initiates the development of coronary artery diseases as an outside-in supply route of inflammation. We have recently demonstrated that drug-eluting stent implantation causes the enhancement of VV formation, with extending to the stent edges in the porcine coronary arteries, and also that optical frequency domain imaging (OFDI) is capable of visualizing VV in humans in vivo. However, it remains to be fully validated whether OFDI enables the precise measurement of VV formation in pigs and humans. METHODS AND RESULTS: In the pig protocol, a total of 6 bare-metal stents and 12 drug-eluting stents were implanted into the coronary arteries, and at 1 month, the stented coronary arteries were imaged by OFDI ex vivo. OFDI data including the measurement of VV area at the stent edge portions were compared with histological data. There was a significant positive correlation between VV area on OFDI and that on histology (R=0.91, P<0.01). In the human protocol, OFDI enabled the measurement of the VV area at the stent edges after coronary stent implantation in vivo. CONCLUSIONS: These results provide the first direct evidence that OFDI enables the precise measurement of the VV area in coronary arteries after stent implantation in pigs and humans.

  58. Clinical Characteristics of Patients With Acute Myocardial Infarction Who Did Not Undergo Primary Percutaneous Coronary Intervention- Report From the MIYAGI-AMI Registry Study. Peer-reviewed

    Kiyotaka Hao, Jun Takahashi, Kenta Ito, Satoshi Miyata, Taro Nihei, Kensuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　79　(9)　2009-16　2015

    DOI： 10.1253/circj.CJ-15-0440 　

    ISSN： 1346-9843

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    BACKGROUND: In the current era of primary percutaneous coronary intervention (PCI), some patients with acute myocardial infarction (AMI) still do not undergo primary PCI. METHODS AND RESULTS: To examine the clinical characteristics of AMI patients who did not undergo primary PCI, we analyzed patients enrolled between 2002 and 2010 in the MIYAGI-AMI Registry Study, in which all AMI patients in the Miyagi prefecture have been prospectively registered. Among a total of 8,640 patients, 1,879 (21.7%) did not undergo primary PCI and their in-hospital mortality was significantly worse compared with those who did (21.4% vs. 6.4%, P<0.01). Multivariate analysis demonstrated that female sex was significantly associated with non-performance of primary PCI [odds ratio (95% confidence interval): 1.40 (1.22-1.61), P<0.001], along with age [1.01 (1.01-1.02), P<0.001] and heart failure on admission [2.69 (2.29-3.16), P<0.001]. When dividing by age, the non-performance rate of primary PCI in females showed a U-shaped prevalence, whereas it simply increased with aging in males. Importantly, female patients aged <80 years had a significantly higher non-performance rate of primary PCI compared with male patients, regardless of the severity of AMI. CONCLUSIONS: These results indicate that in the current PCI era, various factors, including aging, heart failure on admission and sex differences, are associated with non-performance of primary PCI, which remain to be resolved in order to further improve critical care of AMI.

  59. Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake disaster. International-journal Peer-reviewed

    Kiyotaka Hao, Jun Takahashi, Tatsuo Aoki, Satoshi Miyata, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

    International journal of cardiology　177　(2)　569-72　2014/12/15

    DOI： 10.1016/j.ijcard.2014.08.127 　

    ISSN： 0167-5273

  60. In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging - Validation Study Peer-reviewed

    Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Hironori Uzuka, Yuji Odaka, Taro Nihei, Kiyotaka Hao, Ryuji Tsuburaya, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION JOURNAL　78　(10)　2516-2518　2014/10

    DOI： 10.1253/circj.CJ-14-0485 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  61. 循環器診療の最前線と心臓リハビリテーション 大動脈弁硬化症・狭窄症に対する運動療法は有効か禁忌か?

    松本 泰治, 金澤 正範, 竹内 雅史, 羽尾 清貴, 下川 宏明

    日本心臓病学会学術集会抄録　62回　JS4-2　2014/09

    Publisher: (一社)日本心臓病学会

  62. Development of non-invasive regenerative therapy for cardiovascular diseases: Low-energy extracorporeal shock wave therapy Peer-reviewed

    Kenta Ito, Tomohiko Shindo, Tsuyoshi Ogata, Kazuaki Hatanaka, Fukashi Serizawa, Keiichiro Kawamura, Jun Takahashi, Yasuharu Matsumoto, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yuji Odaka, Kenichiro Hanawa, Yuhi Hasebe, Hironori Uzuka, Michinori Hirano, Hitoshi Goto, Hiroaki Shimokawa

    Transactions of Japanese Society for Medical and Biological Engineering　52　68-O-69　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-68 　

    ISSN： 1347-443X 1881-4379

    eISSN： 1347-443X

  63. Extracorporeal low-energy cardiac shock wave therapy exerts beneficial anti-inflammatory effects on left ventricular remodeling after acute myocardial infarction in rats in vivo Peer-reviewed

    Tomohiko Shindo, Kenta Ito, Yuzuru Abe, Tsuyoshi Ogata, Kiyotaka Hao, Kensuke Nishimiya, Satoshi Miyata, Kazuyoshi Kawakami, Hiroaki Shimokawa

    Transactions of Japanese Society for Medical and Biological Engineering　52　80-O-81　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-80 　

    ISSN： 1347-443X 1881-4379

    eISSN： 1347-443X

  64. Emergency care of acute myocardial infarction and the great East Japan earthquake disaster. Peer-reviewed

    Kiyotaka Hao, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yasuhiko Sakata, Taro Nihei, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Satoshi Yasuda, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　78　(3)　634-43　2014

    DOI： 10.1253/circj.CJ-13-1286 　

    ISSN： 1346-9843

    eISSN： 1347-4820

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    BACKGROUND: Although emergency care of acute myocardial infarction (AMI) could theoretically be improved through improved patient delay, this notion remains to be confirmed. Additionally, the influence of large earthquakes on the emergency care of AMI cases remains to be elucidated. The Great East Japan Earthquake (March 11, 2011) has enabled us to address these issues. METHODS AND RESULTS:  We analyzed the data from 2008 to 2011 (n=3,937) in the Miyagi AMI Registry Study. In-hospital mortality was significantly lower in 2011 as compared with the previous 3 years (7.3% vs. 10.5%, P<0.05). This improvement was noted especially during the first 2 months after the Earthquake, associated with shorter elapsing time from onset to admission (120 vs. 240min, P<0.001) and higher performance rate of primary percutaneous coronary intervention (PCI) (86.8% vs. 76.2%, P<0.01). Importantly, after the Earthquake, patients with early admission (≤3h from onset) was significantly increased (59.1% vs. 47.0%, P<0.05) and their prognosis became better (7.9% vs. 11.4%, P=0.02), associated with a lower prevalence of heart failure on admission (6.9% vs. 16.2%, P=0.02) and higher performance rate of primary PCI (89.1% vs. 76.4%, P<0.01). CONCLUSIONS:  Emergency care of AMI improved soon after the Great East Japan Earthquake compared with ordinary times by the contribution of earlier admission from onset and higher performance rate of primary PCI.  (Circ J 2014; 78: 634-643).

  65. Circadian variation of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina. Peer-reviewed

    Taro Nihei, Jun Takahashi, Ryuji Tsuburaya, Yoshitaka Ito, Takashi Shiroto, Kiyotaka Hao, Yusuke Takagi, Yasuharu Matsumoto, Masaharu Nakayama, Satoshi Miyata, Yasuhiko Sakata, Kenta Ito, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　78　(5)　1183-90　2014

    DOI： 10.1253/circj.CJ-13-1458 　

    ISSN： 1346-9843

    eISSN： 1347-4820

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    BACKGROUND: Vasospastic angina (VSA) is known to exhibit circadian variation with an early morning peak. We examined whether Rho-kinase activity in circulating leukocytes, which is a useful biomarker for disease activity assessment of VSA, exhibits circadian variation in patients with VSA. METHODS AND RESULTS: In consecutive 31 VSA patients (M/F 23/8, 57±13 [SD] years) and 18 non-VSA patients (M/F 8/10, 57±14 years), we measured Rho-kinase activity in circulating leukocytes at 6:00, 12:00 and 21:00. We also examined the relationship between the Rho-kinase activity and coronary vasomotor responses during provocation test. Rho-kinase activity was significantly higher in VSA patients than in non-VSA patients at 6:00 (1.17±0.17 vs. 0.92±0.22, P<0.001), and showed a significant circadian variation with a peak at 6:00 (1.00±0.15 at 21:00, 1.17±0.17 at 6:00 and 1.12±0.22 at 12:00, P<0.001) in VSA patients, whereas no such variation was noted in non-VSA patients. Importantly, Rho-kinase activity at spasm provocation test was significantly correlated with basal coronary tone defined by vasodilating responses to intracoronary nitrate (r=0.40, P<0.05) and coronary vasoconstricting responses to acetylcholine (r=0.44, P<0.05) in VSA patients. Furthermore, their Rho-kinase activity at 6:00 was positively correlated with nocturnal parasympathetic activity as evaluated by heart rate variability in Holter monitoring (r=0.48, P<0.05). CONCLUSIONS: Rho-kinase activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses and autonomic activity in VSA patients.

  66. Extracorporeal low-energy shock-wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction. Peer-reviewed

    Yuzuru Abe, Kenta Ito, Kiyotaka Hao, Tomohiko Shindo, Tsuyoshi Ogata, Yuta Kagaya, Ryo Kurosawa, Kensuke Nishimiya, Kimio Satoh, Satoshi Miyata, Kazuyoshi Kawakami, Hiroaki Shimokawa

    Circulation journal : official journal of the Japanese Circulation Society　78　(12)　2915-25　2014

    DOI： 10.1253/circj.CJ-14-0230 　

    ISSN： 1346-9843

    eISSN： 1347-4820

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    BACKGROUND: It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI. METHODS AND RESULTS: AMI was created by ligating the proximal left anterior descending coronary artery in rats. They were randomly assigned to 2 groups: with (SW group) or without (control group) SW therapy (0.1 mJ/mm(2), 200 shots, 1 Hz to the whole heart at 1, 3 and 5 days after AMI). Four weeks after AMI, SW therapy significantly ameliorated LV remodeling and fibrosis. Histological examinations showed that SW therapy significantly suppressed the infiltration of neutrophils and macrophages at days 3 and 6, in addition to enhanced capillary density in the border area. Molecular examinations demonstrated that SW therapy enhanced the expression of endothelial nitric oxide synthase and suppressed the infiltration of transforming growth factor-β1-positive cells early after AMI. SW therapy also upregulated anti-inflammatory cytokines and downregulated pro-inflammatory cytokines in general. CONCLUSIONS: These results suggest that low-energy SW therapy suppressed post-MI LV remodeling in rats in vivo, which was associated with anti-inflammatory effects in addition to its angiogenic effects, and demonstrated a novel aspect of the therapy for AMI.

  67. Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. International-journal Peer-reviewed

    Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S

    Medical gas research　3　(1)　26-26　2013/12

    DOI： 10.1186/2045-9912-3-26 　

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    UNLABELLED: Recent studies have revealed the biological effects of H2 in suppressing organ injuries due to acute inflammation and oxidative stress. Dahl salt-sensitive (SS) rats naturally develop elevated blood pressure (BP) and kidney injury with aging. The present study examined the effect of long-term supplementation of H2 in drinking water on age-related changes.Four-week-old male Dahl SS rats were fed 3 types of water (n = 30 each) for up to 48 weeks: filtered water (FW), water with a high H2 content (492.5 ppb) obtained with water electrolysis (EW), or dehydrogenated EW (DW). Animals were subjected to histological analysis at 16, 24, and 48 weeks.The FW group showed progressive BP elevation and increases in albuminuria and cardiac remodeling during the course of treatment. Histologically, there were significant changes as a function of aging, i.e., glomerular sclerosis with tubulointerstitial fibrosis in the kidney, and increased cardiomyocyte diameter with interstitial fibrosis in the heart at 48 weeks. These changes were related to the enhanced inflammation and oxidative stress in the respective organs. However, there were no striking differences in BP among the groups, despite histological alterations in the EW group being significantly decreased when compared to FW and DW in both organs, with concurrently lower oxidative stress and inflammatory markers at 48 weeks. CONCLUSION: Long-term ad libitum consumption of H2-enriched electrolyzed water can ameliorate the processes of kidney injury and cardiac remodeling with aging in Dahl SS rats by suppressing, at least partly, elevated inflammation and oxidative stress.

  68. 急性心筋梗塞の救急医療と東日本大震災(Emergency Care of Acute Myocardial Infarction and the Great East Japan Earthquake Disaster) Peer-reviewed

    羽尾 清貴, 高橋 潤, 伊藤 健太, 宮田 敏, 坂田 泰彦, 二瓶 太郎, 圓谷 隆治, 白戸 崇, 伊藤 愛剛, 松本 泰治, 中山 雅晴, 安田 聡, 下川 宏明

    日本心臓病学会誌　8　(Suppl.I)　243-243　2013/09

    Publisher: (一社)日本心臓病学会

    ISSN： 1882-4501

  69. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. International-journal Peer-reviewed

    Daisuke Ito, Osamu Ito, Nobuyoshi Mori, Pengyu Cao, Chihiro Suda, Yoshikazu Muroya, Kiyotaka Hao, Hiroaki Shimokawa, Masahiro Kohzuki

    Clinical and experimental pharmacology & physiology　40　(9)　617-25　2013/09

    DOI： 10.1111/1440-1681.12130 　

    ISSN： 0305-1870

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    There is an interaction between heart and kidney diseases, which is a condition termed cardiorenal syndrome. Exercise training has cardioprotective effects, involving upregulation of endothelial (e) nitric oxide synthase (NOS) in the cardiovascular system. However, the effects of exercise training on NOS in the kidney with heart disease are unknown. The aim of the present study was to investigate whether exercise training upregulates NOS in the kidney, left ventricle and aorta of rats with chronic heart failure (CHF). Male Sprague-Dawley rats underwent left coronary artery ligation (LCAL) to induce CHF and were randomly assigned to sedentary or treadmill exercise groups 4 weeks after LCAL. Three days after exercising for 4 weeks, urine samples were collected for 24 h and blood samples were collected following decapitation. Nitric oxide synthase activity and protein expression were examined. Significant interactions between CHF and exercise training were observed on parameters of cardiac and renal function. Exercise training improved cardiac function, decreased plasma B-type natriuretic peptide levels, decreased urinary albumin excretion and increased creatinine clearance in CHF rats. Nitric oxide synthase activity, eNOS expression and neuronal (n) NOS expression were significantly decreased in the left ventricle and kidney of CHF rats. Exercise training significantly increased NOS activity and eNOS and nNOS expression. Upregulation of NOS in the kidney and left ventricle may contribute, in part, to the renal and cardiac protective effects of exercise training in cardiorenal syndrome in CHF rats.

  70. Enhanced Rho-Kinase Activity in Patients With Vasospastic Angina After the Great East Japan Earthquake Peer-reviewed

    Taro Nihei, Jun Takahashi, Yoku Kikuchi, Yusuke Takagi, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

    CIRCULATION JOURNAL　76　(12)　2892-2894　2012/12

    DOI： 10.1253/circj.CJ-12-1238 　

    ISSN： 1346-9843

  71. Urbanization, Life Style Changes and the Incidence/In-Hospital Mortality of Acute Myocardial Infarction in Japan - Report From the MIYAGI-AMI Registry Study Peer-reviewed

    Kiyotaka Hao, Satoshi Yasuda, Tori Takii, Yoshitaka Ito, Jun Takahashi, Kenta Ito, Masaharu Nakayama, Nobuyuki Shiba, Yoshihiro Fukumoto, Hiroaki Shimokawa

    CIRCULATION JOURNAL　76　(5)　1136-1144　2012/05

    DOI： 10.1253/circj.CJ-11-1233 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  72. Long-Term Treatment With Eicosapentaenoic Acid Ameliorates Myocardial Ischemia-Reperfusion Injury in Pigs In Vivo - Involvement of Rho-Kinase Pathway Inhibition Peer-reviewed

    Jun Yi Gao, Satoshi Yasuda, Ryuji Tsuburaya, Yoshitaka Ito, Takashi Shiroto, Kiyotaka Hao, Kentaro Aizawa, Yoku Kikuchi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION JOURNAL　75　(8)　1843-1851　2011/08

    DOI： 10.1253/circj.CJ-11-0209 　

    ISSN： 1346-9843

    eISSN： 1347-4820

  73. 慢性心不全モデルラットの血圧と心・腎Nitric Oxide合成酵素に対する長期的運動の影響

    伊藤 大亮, 伊藤 修, 森 信芳, 須田 千尋, 羽尾 清貴, 曹 鵬宇, 戎 栄, 下川 宏明, 上月 正博

    日本高血圧学会総会プログラム・抄録集　33回　350-350　2010/10

    Publisher: (NPO)日本高血圧学会

  74. 慢性心不全モデルラットの心・腎NO合成酵素に対する長期的運動の影響

    伊藤 大亮, 伊藤 修, 森 信芳, 須田 千尋, 羽尾 清貴, 曹 鵬宇, 戎 栄, 下川 宏明, 上月 正博

    日本運動療法学会大会抄録集　35回　55-55　2010/07

    Publisher: 日本運動療法学会

  75. Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris Peer-reviewed

    Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa

    CIRCULATION JOURNAL　74　(3)　589-591　2010/03

    DOI： 10.1253/circj.CJ-09-1028 　

    ISSN： 1346-9843

  76. 両側高度肺動脈狭窄を伴った大動脈炎症候群の1例

    細田 奈生, 玉田 芳明, 羽尾 清貴, 近江 晃樹, 青木 竜男, 高橋 健太郎, 福井 昭男, 松井 幹之, 矢作 友保, 後藤 敏和, 荒木 隆夫

    Circulation Journal　71　(Suppl.III)　933-933　2007/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

    eISSN： 1347-4820

  77. Genetic testing of glycogen storage disease type Ib in Japan: five novel G6PT1 mutations and a rapid detection method for a prevalent mutation W118R Peer-reviewed

    K Kojima, S Kure, F Kamada, K Hao, A Ichinohe, K Sato, Y Aoki, S Yoichi, M Kubota, R Horikawa, A Utsumi, M Miura, S Ogawa, M Kanazawa, Y Kohno, M Inokuchi, T Hasegawa, K Narisawa, Y Matsubara

    MOLECULAR GENETICS AND METABOLISM　81　(4)　343-346　2004/04

    DOI： 10.1016/j.ymgme.2003.12.004 　

    ISSN： 1096-7192

Show all ︎Show first 5

Misc. 110

  1. 急性心筋梗塞発症率と院内死亡率の40年間の変遷と性差に関する検討;MIYAGI-AMI Registry

    船木崇裕, 羽尾清貴, 進藤智彦, 大山宗馬, 神戸茂雄, 白戸崇, 高橋潤, 安田聡

    日本性差医学・医療学会学術集会プログラム・抄録集　18th　2025

  2. A case of infolding diagnosed by transesophageal echocardiography during transcatheter aortic valve replacement

    船木崇裕, 羽尾清貴, 勝田祐子, 進藤智彦, 菊池翼, 後岡広太郎, 白戸崇, 鈴木祐輔, 齋木佳克, 安田聡

    超音波医学 Supplement　52　2025

    ISSN： 1881-9311

  3. A case of successful bridge to an implantable LVAD in a patient with severe STEMI by choosing the appropriate use of supplemental circulation

    吉町文子, 進藤智彦, 神戸茂雄, 西宮健介, 羽尾清貴, 白戸崇, 高橋潤, 安田聡, 細山勝寛, 鈴木祐輔, 片平晋太郎, 齋木佳克

    東北医学雑誌(Web)　136　(2)　77-80　2024/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  4. Prognostic Significance of Coronary Microvascular Vasodilatory Dysfunction in Patients with Epicardial Coronary Spasm

    高橋潤, 福井健人, 神戸茂雄, 羽尾清貴, 大山宗馬, 西宮健介, 進藤智彦, 白戸崇, 安田聡

    日本循環器学会学術集会(Web)　88th　2024

  5. Gender differences in cardiology

    羽尾清貴, 安田聡

    医学のあゆみ　290　(10)　2024

    ISSN： 0039-2359

  6. 今この研究が面白い![第2章:循環器]虚血性心疾患 マクロとミクロの観点からみた冠動脈機能異常

    羽尾清貴, 安田聡

    内科　134　(3)　2024

    ISSN： 0022-1961

  7. Diagnostic approach to ischemic heart disease

    羽尾清貴, 安田聡

    日本臨床　82　2024

    ISSN： 0047-1852

  8. 急性心筋梗塞に対する医療体制の地域および施設間格差に関する検討-Miyagi AMI Registry Studyからの報告-

    羽尾清貴, 高橋潤, 進藤智彦, 大山宗馬, 神戸茂雄, 白戸崇, 安田聡

    日本心臓病学会学術集会(Web)　72nd　2024

  9. A case in which a thrombus that appeared during MitraClip surgery was confirmed by transesophageal echocardiography and thromboembolism was averted

    粕壁幸恵, 勝田祐子, 後岡広太郎, 千葉貴彦, 西宮健介, 神戸茂雄, 羽尾清貴, 白戸崇, 高橋潤, 安田聡

    超音波医学 Supplement　50　2023

    ISSN： 1881-9311

  10. In-hospital Outcome of Patients with Myocardial Infarction with Non-obstructive Coronary Artery; Insight from the Multi-center Miyagi-AMI Registry Enrolling 8,881 Japanese

    羽尾清貴, 高橋潤, 福井健人, 中田貴史, 進藤智彦, 大山宗馬, 西宮健介, 神戸茂雄, 白戸崇, 下川宏明, 安田聡

    日本循環器学会学術集会(Web)　87th　2023

  11. Comparison of Long-term Mortality of Transcatheter Aortic Valve Implantation between Patients Aged ≧80 Years and those <80 Years(和訳中)

    菊地 翼, 高橋 潤, 羽尾 清貴, 西宮 健介, 神戸 茂雄, 勝田 祐子, 須田 彬, 進藤 智彦, 白戸 崇, 熊谷 紀一郎, 齋木 佳克, 安田 聡

    日本循環器学会学術集会抄録集　86回　PL10-2　2022/03

    Publisher: (一社)日本循環器学会

  12. Novel Therapeutic Application of Low-Intensity Pulsed Ultrasound for Coronary Artery Disease-Clinical Application of Mechano-tranduction Mechanisms-

    進藤智彦, 安田聡, 中田貴史, 神戸茂雄, 西宮健介, 羽尾清貴, 菊地翼, 白戸崇, 高橋潤, 金井浩, 下川宏明

    日本循環器学会学術集会(Web)　86th　2022

  13. Association between Coronary Atherosclerotic and Inflammatory Changes and Magnitude of Myocardial Bridge

    渡辺翼, 西宮健介, 大田英輝, 樋口慧, 山本絵里香, 竹内智, 福井健人, 須田彬, 神戸茂雄, 進藤智彦, 羽尾清貴, 菊地翼, 白戸崇, 高橋潤, 安田聡

    日本循環器学会学術集会(Web)　86th　2022

  14. 宮城県における12誘導心電図伝送システム導入の効果に関する検討

    羽尾清貴, 高橋潤, 富岡智子, 岩渕薫, 安田聡

    ICUとCCU　46　(8)　2022

    ISSN： 0389-1194

  15. TAVI後せん妄の最大の予測因子は術後フレイルでありせん妄との合併は半年後の機能予後と関連する

    竹内雅史, 松本泰治, 西宮健介, 羽尾清貴, 神戸茂雄, 進藤智彦, 大山宗馬, 鈴木秀明, 白戸崇, 高橋潤, 安田聡, 海老原覚, 海老原覚

    日本心不全学会学術集会プログラム・抄録集　26th　2022

  16. Association between Myocardial Bridge and Atherosclerotic and Inflammatory Changes

    渡辺翼, 西宮健介, 大田英輝, 樋口慧, 山本絵里香, 竹内智, 福井健人, 須田彬, 神戸茂雄, 進藤智彦, 羽尾清貴, 菊地翼, 白戸崇, 高橋潤, 安田聡

    血管(Web)　45　(1)　2022

    ISSN： 2759-2286

  17. TAVIは重症大動脈弁狭窄症患者のBNP値の低下に伴う冠微小血管の拡張機能障害を改善する(TAVI Improves Impaired Vasodilator Capacity of Coronary Microvessels Associated with Decreased BNP Levels in Patients with Severe Aortic Stenosis)

    土屋 聡, 松本 泰治, 杉澤 潤, 佐藤 公一, 須田 彬, 進藤 智彦, 神戸 茂雄, 西宮 健介, 竹内 雅史, 菊地 翼, 羽尾 清貴, 高橋 潤, 熊谷 紀一郎, 齋木 佳克, 下川 宏明

    日本循環器学会学術集会抄録集　84回　PJ18-8　2020/07

    Publisher: (一社)日本循環器学会

  18. 冠動脈閉塞を伴わない心筋梗塞(MINOCA)患者に関する検討-宮城県AMI登録研究-

    羽尾清貴, 高橋潤, 佐藤公一, 須田彬, 進藤智彦, 神戸茂雄, 西宮健介, 菊地翼, 白戸崇, 坂田泰彦, 下川宏明

    脈管学(Web)　60　(supplement)　2020

    ISSN： 1880-8840

  19. Exercise Training Ameliorates Vasodilator Capacity of Coronary Microvessels in Patients With Vasospastic Angina -A New Therapeutic Approach for the Coronary Functional Disorder

    Jun Sugisawa, Yasuharu Matsumoto, Akira Suda, Satoshi Tsuchiya, Kazuma Ohyama, Masashi Takeuchi, Kensuke Nishimiya, Mina Akizuki, Koichi Sato, Shoko Kajitani, Hideki Ota, Shohei Ikeda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Kei Takase, Masahiro Kohzuki, Hiroaki Shimokawa

    CIRCULATION　140　2019/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  20. 冠攣縮性狭心症患者における冠血流予備能と運動耐容能の関連

    杉澤 潤, 松本 泰治, 羽尾 清貴, 竹内 雅史, 秋月 三奈, 須田 彬, 左藤 公一, 土屋 聡, 梶谷 翔子, 進藤 智彦, 菊地 翼, 白戸 崇, 高橋 潤, 上月 正博, 下川 宏明

    日本心臓病学会学術集会抄録　67回　O-063　2019/09

    Publisher: (一社)日本心臓病学会

  21. 再開胸手術が困難とされたBentall手術後の左右冠動脈口と人工血管吻合部の高度狭窄にPCIを施行した大動脈炎症候群の一例

    池田 尚平, 高橋 潤, 菊地 翼, 須田 彬, 進藤 智彦, 羽尾 清貴, 松本 泰治, 吉岡 一朗, 齋木 佳克, 下川 宏明

    日本心血管インターベンション治療学会抄録集　28回　[MO61-004]　2019/09

    Publisher: (一社)日本心血管インターベンション治療学会

  22. PCI時代における冠動脈機能異常の重要性 胸痛を有する非閉塞性冠動脈疾患患者における冠動脈機能異常に関する包括的評価

    須田 彬, 高橋 潤, 羽尾 清貴, 菊地 翼, 進藤 智彦, 池田 尚平, 佐藤 公一, 杉澤 潤, 松本 泰治, 宮田 敏, 坂田 泰彦, 下川 宏明

    日本心血管インターベンション治療学会抄録集　28回　[S28-2]　2019/09

    Publisher: (一社)日本心血管インターベンション治療学会

  23. 再開胸手術が困難とされたBentall手術後の左右冠動脈口と人工血管吻合部の高度狭窄にPCIを施行した大動脈炎症候群の一例

    池田 尚平, 高橋 潤, 菊地 翼, 須田 彬, 進藤 智彦, 羽尾 清貴, 松本 泰治, 吉岡 一朗, 齋木 佳克, 下川 宏明

    日本心血管インターベンション治療学会抄録集　28回　[MO61-004]　2019/09

    Publisher: (一社)日本心血管インターベンション治療学会

  24. 高齢大動脈弁狭窄症におけるTAVI術後せん妄はフレイル患者に多く半年後の低身体機能を予測する

    竹内 雅史, 松本 泰治, 土屋 聡, 杉澤 潤, 羽尾 清貴, 菊地 翼, 高橋 潤, 宮田 敏, 上月 正博, 齋木 佳克, 下川 宏明

    日本循環器学会学術集会抄録集　83回　CP14-1　2019/03

    Publisher: (一社)日本循環器学会

  25. 高齢大動脈弁狭窄症におけるTAVI術後せん妄はフレイル患者に多く半年後の低身体機能を予測する

    竹内 雅史, 松本 泰治, 土屋 聡, 杉澤 潤, 羽尾 清貴, 菊地 翼, 高橋 潤, 宮田 敏, 上月 正博, 齋木 佳克, 下川 宏明

    日本循環器学会学術集会抄録集　83回　CP14-1　2019/03

    Publisher: (一社)日本循環器学会

  26. 非ST上昇型心筋梗塞における性差の検討-宮城AMI登録研究からの報告-

    佐藤公一, 高橋潤, 羽尾清貴, 須田彬, 進藤智彦, 菊地翼, 松本泰治, 宮田徹, 坂田泰彦, 下川宏明, 下川宏明

    日本性差医学・医療学会学術集会プログラム・抄録集　12th　2019

  27. 非閉塞性冠動脈疾患における冠動脈機能異常の包括的評価

    須田彬, 高橋潤, 羽尾清貴, 菊地翼, 進藤智彦, 佐藤公一, 杉澤潤, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明

    脈管学(Web)　59　(supplement)　2019

    ISSN： 1880-8840

  28. Prognostic Impacts of Impaired Coronary Vasodilator Function and Enhanced Vasoconstriction Responses in Patients With Angina and Unobstructive Coronary Arteries

    Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Shohei Ikeda, Koichi Sato, Jun Sugisawa, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　138　2018/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  29. 冠血管反応の制御における心臓リンパ管の重要性―薬剤溶出性ステント留置後のブタモデルを用いた検討―

    天水宏和, 松本泰治, 諸沢薦, 大山宗馬, 宇塚裕紀, 平野道基, 杉澤潤, 土屋聡, 佐藤公一, 須田彬, 進藤智彦, 池田尚平, 西宮健介, 菊地翼, 羽尾清貴, 白戸崇, 高橋潤, 林もゆる, 河合佳子, 下川宏明

    リンパ学　41　(Supplement)　28　2018/05/07

    ISSN： 0910-4186

  30. 胸痛を伴う運動誘発性左脚ブロックの一例

    進藤智彦, 高橋潤, 松本泰治, 白戸崇, 菊地翼, 羽尾清貴, 池田尚平, 須田彬, 杉澤潤, 土屋聡, 梶谷翔子, 佐藤公一, 下川宏明

    日本循環器学会東北地方会(Web)　166th　2018

  31. 急性心筋梗塞後に偽性仮性心室瘤と中隔穿孔を合併し,慢性期にパッチ閉鎖術と左室形成術を施行した一例

    菊地翼, 佐藤公一, 杉澤潤, 土屋聡, 進藤智彦, 池田尚平, 羽尾清貴, 白戸崇, 松本泰治, 高橋潤, 下川宏明, 川本俊輔, 鈴木祐輔, 秋山正年, 齋木佳克, 伊藤愛剛, 井上寛一

    日本循環器学会東北地方会(Web)　166th　2018

  32. 冠攣縮性狭心症患者における冠血流予備能と運動耐容能の関連

    杉澤潤, 松本泰治, 羽尾清貴, 須田彬, 竹内雅史, 土屋聡, 佐藤公一, 進藤智彦, 池田尚平, 菊地翼, 高橋潤, 下川宏明

    日本臨床運動療法学会雑誌　20　(1)　69-69　2018

    Publisher: (NPO)日本臨床運動療法学会

  33. 非閉塞性冠動脈を伴う心筋梗塞(MINOCA)患者の臨床像―宮城県AMI登録研究―

    羽尾清貴, 高橋潤, 佐藤公一, 進藤智彦, 池田尚平, 菊地翼, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明, 下川宏明

    日本性差医学・医療学会学術集会プログラム・抄録集　11th　111　2018

  34. 高齢急性心筋梗塞患者におけるプライマリー冠動脈インターベンション治療効果の性差に関する検討

    佐藤公一, 高橋潤, 羽尾清貴, 進藤智彦, 池田尚平, 菊地翼, 松本泰治, 宮田敏, 坂田泰彦, 下川宏明, 下川宏明

    日本性差医学・医療学会学術集会プログラム・抄録集　11th　104　2018

  35. 冠動脈過収縮反応における心臓リンパ管の重要性 ブタ動物モデルを用いた検討

    天水 宏和, 松本 泰治, 諸沢 薦, 大山 宗馬, 宇塚 裕紀, 平野 道基, 杉澤 潤, 土屋 聡, 佐藤 公一, 須田 彬, 進藤 智彦, 池田 尚平, 西宮 健介, 菊地 翼, 羽尾 清貴, 白戸 崇, 高橋 潤, 下川 宏明

    血管　41　(1)　36-36　2018/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  36. Temporal Trends in Emergency Care and Outcomes of Geriatric Patients With Acute Myocardial Infarction in Japan -A Report From the Miyagi AMI Registry Study

    Koichi Sato, Jun Takahashi, Yuanji Cui, Kiyotaka Hao, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　136　2017/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  37. Evidence for Enhanced Inflammation of Coronary Adventitia and Perivascular Adipose Tissue With Altered Disease Activity in Vasospastic Angina Patients -A Multi-modality Imaging Study

    Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　136　2017/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  38. Sex Differences in Coronary Microvascular Dysfunction in Patients With Vasospastic Angina

    Akira Suda, Jun Takahashi, Kiyotaka Hao, Yoku Kikuchi, Tomohiko Shindo, Yasuharu Matsumoto, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　136　2017/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  39. 急性心不全発症を契機に発見された巨大左室内血栓の1例

    杉澤潤, 菊地翼, 土屋聡, 佐藤公一, 照井洋輔, 青柳肇, 進藤智彦, 池田尚平, 羽尾清貴, 白戸崇, 松本泰治, 高橋潤, 坂田泰彦, 河津聡, 川本俊輔, 齋木佳克, 下川宏明

    日本循環器学会東北地方会(Web)　165th　2017

  40. Valsalva洞径から検討した経カテーテル的大動脈弁置換術(TAVI)deviceの選択-当院における経験-

    土屋聡, 松本泰治, 菊地翼, 杉澤潤, 羽尾清貴, 高橋潤, 川本俊輔, 熊谷紀一郎, 齋木佳克, 下川宏明

    日本循環器学会東北地方会(Web)　164th　2017

  41. Usefulness of Dual Induction Tests for Coronary Artery Spasm and Lethal Ventricular Arrhythmias in Patients Surviving Out-of-Hospital Cardiac Arrest

    Masayasu Komatsu, Jun Takahashi, Makoto Nakano, Masateru Kondo, Ryuji Tsuburaya, Kiyotaka Hao, Kensuke Nishimiya, Taro Nihei, Yasuharu Matsumoto, Kenta Ito, Koji Fukuda, Hiroaki Shimokawa

    CIRCULATION　134　2016/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  42. Prognostic Impact of Residual Coronary Stenosis in Patients With Ischemic Heart Failure After Percutaneous Coronary Intervention

    Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Yasuhiko Sakata, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　22　(9)　S156-S156　2016/09

    DOI： 10.1016/j.cardfail.2016.07.026 　

    ISSN： 1071-9164

    eISSN： 1532-8414

  43. 急性心筋梗塞発症率及び院内死亡率の経年変化に関する検討―Miyagi AMI Registry Study(1985‐2014)からの報告―

    崔元吉, 羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

    日本内科学会雑誌　105　157　2016/02/20

    ISSN： 0021-5384

  44. 低心機能を伴った重症大動脈弁狭窄症に人工心肺サポート下でTAVIを施行した2例

    土屋聡, 松本泰治, 高橋潤, 杉村宏一郎, 菊地翼, 羽尾清貴, 進藤智彦, 須田彬, 杉澤潤, 熊谷紀一郎, 川本俊輔, 齋木佳克, 下川宏明

    日本循環器学会東北地方会(Web)　163rd　2016

  45. 心室細動で発症し冠攣縮性狭心症と肺高血圧症を合併した好酸球性多発血管炎性肉芽腫症(EGPA)の1例

    紺野亮, 建部俊介, 杉村宏一郎, 青木竜男, 山本沙織, 矢尾板信裕, 佐藤遥, 神津克也, 羽尾清貴, 高橋潤, 中野誠, 福田浩二, 白井剛志, 杉浦久敏, 中嶋壮太, 石井智徳, 下川宏明

    日本循環器学会東北地方会(Web)　163rd　TOHOKU163,4 (WEB ONLY)　2016

  46. 心サルコイドーシスに冠攣縮性狭心症を合併した2症例

    崔元吉, 羽尾清貴, 西宮健介, 圓谷隆治, 松本泰治, 高橋潤, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　162nd　TOHOKU162,28 (WEB ONLY)　2016

  47. Hybrid手術室において集約的加療を要した「たこつぼ型心筋症」の一例

    須田彬, 西宮健介, 圓谷隆治, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 佐藤英昭, 森川孝則, 海野倫明, 下川宏明

    日本循環器学会東北地方会(Web)　162nd　TOHOKU162,12 (WEB ONLY)　2016

  48. 血漿セロトニン濃度は冠微小血管障害を反映する

    小鷹悠二, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 須田彬, 小松真恭, 松本泰治, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　162nd　TOHOKU162,9 (WEB ONLY)　2016

  49. 冠微小血管障害と血漿セロトニン濃度

    小鷹悠二, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 須田彬, 小松真恭, 松本泰治, 伊藤健太, 下川宏明

    日本心臓病学会学術集会(Web)　64th　ROMBUNNO.S8‐5 (WEB ONLY)　2016

  50. 情報共有で慢性心不全患者の問題に対応―カンファレンスや勉強会でチーム力をレベルアップ 演題3 東北大学病院における多職種チーム(HEARTチーム)の立ち上げの現状と課題

    梶川アユミ, 田中裕美, 齊藤夕貴, 佐々木百合花, 三浦正暢, 羽尾清貴, 近藤正輝, 杉村宏一郎, 下川宏明, 柿花隆昭, 鈴木寿樹, 庄島和世

    Therapeutic Research　36　(11)　1045‐1048　2015/11/20

    ISSN： 0289-8020

  51. Increased Coronary Perivascular Adipose Tissue Volume on Cardiac Computed Tomography in Patients With Vasospastic Angina-Possible Correlation With Adventitial Vasa Vasorum Formation

    Kazuma Ohyama, Yasuharu Matsumoto, Hirokazu Amamizu, Hironori Uzuka, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　132　2015/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  52. Temporal Trends in Incidence and Mortality of Acute Myocardial Infarction for 30 Years in Japan -A Report From the Miyagi AMI Registry Study

    Yuanji Cui, Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　132　2015/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  53. Clinical Characteristics of Patients With Acute Myocardial Infarction Who Did Not Receive Primary Percutaneous Coronary Intervention in Japan -Report From the Miyagi-AMI Registry Study

    Kiyotaka Hao, Jun Takahashi, Kenta Ito, Yuanji Cui, Satoshi Miyata, Kensuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa

    CIRCULATION　132　2015/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  54. Association of Enhanced Adventitial Vasa Vasorum Formation With Atherosclerotic Changes in the Human Coronary Arteries Adjacent to Myocardial Bridging -An Optical Frequency Domain Imaging Study

    Hongxin Wang, Yasuharu Matsumoto, Kensuke Nishimiya, Jun Takahashi, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Hirokazu Amamizu, Kazuma Ohyama, Masayasu Komatsu, Yuji Odaka, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　132　2015/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  55. 冠微小循環障害と血中セロトニンの関連の検討

    小鷹 悠二, 高橋 潤, 須田 彬, 小松 真恭, 西宮 健介, 羽尾 清貴, 円谷 隆治, 松本 泰治, 伊藤 健太, 下川 宏明

    脈管学　55　(Suppl.)　S137-S137　2015/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

  56. 冠動脈攣縮の成因における外膜の役割

    西宮健介, 松本泰治, 宇塚裕紀, 大山宗馬, 進藤智彦, 平野道基, 小鷹悠二, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)　47th　131 (WEB ONLY)　2015/06/25

  57. たこつぼ型心筋症様の収縮障害を来たした褐色細胞腫の一例

    古知龍三郎, 青木竜男, 杉村宏一郎, 建部俊介, 三浦正暢, 矢尾板信裕, 佐藤遥, 高橋潤, 松本泰治, 羽尾清貴, 佐藤公雄, 下川宏明

    日本循環器学会東北地方会(Web)　160th　TOHOKU160,28 (WEB ONLY)　2015

  58. 多発性硬化症の脳幹病変によるたこつぼ心筋症の一例

    神津克也, 鈴木秀明, 西山修平, 佐藤遥, 矢尾板信裕, 山本沙織, 羽尾清貴, 三浦正暢, 建部俊介, 青木竜男, 松本泰治, 杉村宏一郎, 青木正志, 下川宏明

    日本循環器学会東北地方会(Web)　161st　TOHOKU161,5 (WEB ONLY)　2015

  59. 急性心筋梗塞発症率と院内死亡率の経年変化における性差の検討―MIYAGI‐AMI Registry Studyからの報告―

    羽尾清貴, 高橋潤, 伊藤健太, 崔元吉, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

    日本性差医学・医療学会学術集会プログラム・抄録集　8th　65　2015

  60. 閉塞性肥大型心筋症にたこつぼ型心筋症を併発した肺移植症例

    西宮健介, 羽尾清貴, 圓谷隆治, 松本泰治, 高橋潤, 伊藤健太, 渡邊龍秋, 星川康, 岡田克典, 下川宏明

    日本循環器学会東北地方会(Web)　160th　TOHOKU160,62 (WEB ONLY)　2015

  61. 乳酸アシドーシスを合併した非ST上昇型心筋梗塞の一例

    圓谷隆治, 高橋潤, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　160th　TOHOKU160,52 (WEB ONLY)　2015

  62. 外傷性くも膜下出血と急性心筋梗塞を合併した一例

    須田彬, 高橋潤, 神戸茂雄, 宮川乃理子, 西宮健介, 羽尾清貴, 圓谷隆治, 松本泰治, 久志本成樹, 下川宏明

    日本循環器学会東北地方会(Web)　161st　TOHOKU161,53 (WEB ONLY)　2015

  63. 非心臓手術中に発症した薬剤溶出ステント留置後亜急性ステント血栓症の一例

    深澤恭之朗, 圓谷隆治, 高橋潤, 須田彬, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　161st　TOHOKU161,59 (WEB ONLY)　2015

  64. 急性心筋梗塞発症率及び院内死亡率の年代別経年変化の検討―Miyagi AMI Registry Studyからの報告

    崔元吉, 羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

    日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.P‐247 (WEB ONLY)　2015

  65. 急性心筋梗塞の発症率と院内死亡率の近年における経年変化―MIYAGI‐AMI Registry Studyからの報告―

    羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 崔元吉, 西宮健介, 圓谷隆治, 松本泰治, 坂田泰彦, 下川宏明

    日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.S2‐8 (WEB ONLY)　2015

  66. 急性心筋梗塞後の左室リモデリングに対する低出力体外衝撃波治療の効果

    加賀谷裕太, 伊藤健太, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 進藤智彦, 尾形剛, 黒澤亮, 江口久美子, 畠中和明, 宮田敏, 下川宏明

    日本循環器学会東北地方会(Web)　161st　TOHOKU161,54 (WEB ONLY)　2015

  67. Fabry病に冠攣縮性狭心症を合併した一例

    羽尾清貴, 西宮健介, 山本沙織, 圓谷隆治, 松本泰治, 杉村宏一郎, 高橋潤, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　161st　TOHOKU161,57 (WEB ONLY)　2015

  68. 冠動脈攣縮における冠動脈イメージングの重要性

    西宮健介, 松本泰治, 宇塚裕紀, 大山宗馬, 進藤智彦, 平野道基, 小鷹悠二, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

    日本心臓病学会学術集会(Web)　63rd　ROMBUNNO.S1‐5 (WEB ONLY)　2015

  69. 冠微小循環障害と血中セロトニンの関連の検討

    小鷹悠二, 高橋潤, 須田彬, 小松真恭, 西宮健介, 羽尾清貴, 円谷隆治, 松本泰治, 伊藤健太, 下川宏明

    脈管学(Web)　55　(supplement)　S137(J‐STAGE)　2015

    ISSN： 1880-8840

  70. Enhanced Adventitial Vasa Vasorum Formation in Patients With Vasospastic Angina -Assessment With Optical Frequency Domain Imaging-

    Kensuke Nishimiya, Yasuharu Matsumoto, Jun Takahashi, Takeshi Kato, Kazuma Oyama, Uzuka Hironori, Yuji Odaka, Taro Nihei, Kiyotaka Hao, Ryuji Tsuburaya, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　130　2014/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  71. Factors Influencing the Occurrence of Cardiopulmonary Arrest in the Great East Japan Earthquake Disaster

    Kiyotaka Hao, Jun Takahashi, Tatsuo Aoki, Satoshi Miyata, Taro Nihei, Shunsuke Nishimiya, Ryuji Tsuburaya, Yasuharu Matsumoto, Kenta Ito, Yasuhiko Sakata, Hiroaki Shimokawa

    CIRCULATION　130　2014/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  72. Prognostic Impact of Rho-kinase Activity in Circulating Leukocytes of Patients with Vasospastic Angina

    Taro Nihei, Jun Takahashi, Ryuji Tsuburaya, Kiyotaka Hao, Yuji Odaka, Kensuke Nishimiya, Yasuharu Matsumoto, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　130　2014/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  73. 低出力体外衝撃波治療 心血管疾患に対する新しい非侵襲性血管新生療法

    伊藤 健太, 高橋 潤, 松本 泰治, 圓谷 隆治, 羽尾 清貴, 西宮 健介, 二瓶 太郎, 下川 宏明

    脈管学　54　(Suppl.)　S149-S149　2014/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

  74. 重度腎機能障害例における冠動脈インターベンション後の腎機能悪化に対する予防的血液透析の効果に関する検討

    圓谷隆治, 高橋潤, 二瓶太郎, 西宮健介, 羽尾清貴, 白戸崇, 松本泰治, 伊藤健太, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-145　2014/09/02

  75. Optical Frequency Domain Imaging(OFDI)による冠動脈外膜Vasa Vasorumの生体内画像評価

    西宮健介, 松本泰治, 宇塚裕紀, 進藤智彦, 長谷部雄飛, 二瓶太郎, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-058-058　2014/09/02

    Publisher: (一社)日本心臓病学会

  76. 冠微小血管攣縮と血中セロトニンの関連の検討

    小鷹悠二, 円谷隆治, 高橋潤, 二瓶太郎, 西宮健介, 羽尾清貴, 松本泰治, 伊藤健太, 廣渡祐史, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-271　2014/09/02

  77. 冠動脈攣縮に関する画像研究の新知見

    西宮健介, 松本泰治, 宇塚裕紀, 尾形剛, 小鷹悠二, 平野道基, 進藤智彦, 長谷部雄飛, 二瓶太郎, 羽尾清貴, 圓谷隆治, 高橋潤, 伊藤健太, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.S16-1　2014/09/02

  78. 急性心筋梗塞患者における冠動脈インターベンション未施行例の特徴―宮城県心筋梗塞対策協議会からの報告―

    羽尾清貴, 高橋潤, 伊藤健太, 宮田敏, 坂田泰彦, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 安田聡, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-378　2014/09/02

  79. 冠攣縮性狭心症の病態における冠動脈外膜Vasa Vasorumの関与―光干渉断層画像(OFDI)を用いた臨床的検討―

    西宮健介, 松本泰治, 高橋潤, 宇塚裕紀, 小鷹悠二, 二瓶太郎, 羽尾清貴, 圓谷隆治, 伊藤健太, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-059　2014/09/02

  80. 薬剤溶出性ステント留置後にステント離断をきたし冠動脈瘤を形成した若年川崎病後遺症の一例

    二瓶太郎, 高橋潤, 小鷹悠二, 西宮健介, 羽尾清貴, 圓谷隆二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-021　2014/09/02

  81. 冠攣縮性狭心症の長期予後予測におけるRhoキナーゼ活性の有用性

    二瓶太郎, 高橋潤, 小鷹悠二, 西宮健介, 羽尾清貴, 圓谷隆二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-269　2014/09/02

  82. 東日本大震災後に認められた心肺停止症例の増加に関係する因子の検討

    羽尾清貴, 高橋潤, 青木竜男, 宮田敏, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本心臓病学会学術集会抄録(CD-ROM)　62nd　ROMBUNNO.O-137　2014/09/02

  83. 院外で心肺停止となり,蘇生後6日目の急性冠症候群から生還した維持透析患者の一例

    田中祥朗, 佐藤哲哉, 工藤大介, 村田弥栄子, 山本多恵, 羽尾清貴, 宮崎真理子

    東北腎不全研究会プログラム・抄録集　41st　60　2014/08

  84. 長期的運動は慢性心不全モデルラットの心・腎一酸化窒素合成酵素を増強させる

    伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 阿部倫明, 阿部倫明, 清元秀泰, 清元秀泰, 石井正, 石井正, 上月正博

    日本NO学会学術集会プログラム抄録集　14th　2014

  85. 冠攣縮性狭心症の鑑別が有用であった冠動脈インターベンションによる完全血行再建後の1例

    羽尾清貴, 高橋潤, 二瓶太郎, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本循環器学会東北地方会(Web)　158th　TOHOKU158,62 (WEB ONLY)　2014

  86. 冠動脈ステント破損が冠動脈瘤形成に関与した若年川崎病後遺症の一例

    二瓶太郎, 高橋潤, 圓谷隆治, 羽尾清貴, 西宮健介, 小鷹悠二, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本循環器学会東北地方会(Web)　158th　TOHOKU158,63 (WEB ONLY)　2014

  87. 薬剤負荷心筋血流シンチにて陽性所見を呈した冠攣縮性狭心症の一例

    山内悠平, 圓谷隆治, 二瓶太郎, 西宮健介, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 坂田泰彦, 下川宏明

    日本循環器学会東北地方会(Web)　158th　TOHOKU158,64 (WEB ONLY)　2014

  88. ステロイド補充開始後に冠攣縮性狭心症発作を認めたACTH単独欠損症の一例

    小松真恭, 西宮健介, 高橋潤, 圓谷隆治, 二瓶太郎, 羽尾清貴, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本循環器学会東北地方会(Web)　159th　TOHOKU159,48 (WEB ONLY)　2014

  89. 低出力体外衝撃波治療:心血管疾患に対する新しい非侵襲性血管新生療法

    伊藤健太, 高橋潤, 松本泰治, 圓谷隆治, 羽尾清貴, 西宮健介, 二瓶太郎, 下川宏明

    脈管学(Web)　54　(Supplement)　S149(J-STAGE)　2014

    ISSN： 1880-8840

  90. 冠攣縮性狭心症を合併した肥大型心筋症の一例

    金沙織, 羽尾清貴, 大山宗馬, 高橋潤, 西宮健介, 圓谷隆治, 松本泰治, 伊藤健太, 坂田泰彦, 下川宏明

    日本循環器学会東北地方会(Web)　159th　TOHOKU159,49 (WEB ONLY)　2014

  91. 全身性エリテマトーテスによる冠動脈拡張により生じた急性冠症候群の一例

    中嶋優太, 圓谷隆治, 西宮健介, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 下川宏明

    日本循環器学会東北地方会(Web)　159th　TOHOKU159,56 (WEB ONLY)　2014

  92. Emergency Care of Acute Myocardial Infarction during the Great East Japan Earthquake Disaster-Report from the Miyagi AMI Registry Study-

    Kiyotaka Hao, Jun Takahashi, Satoshi Miyata, Yasuharu Sakata, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　19　(10)　S154-S154　2013/10

    DOI： 10.1016/j.cardfail.2013.08.239 　

    ISSN： 1071-9164

    eISSN： 1532-8414

  93. Epidemiology of acute coronary syndrome

    141　(12)　2626-2630　2013/03

    Publisher: 日本医師会

    ISSN： 0021-4493

  94. Enhanced Rho-kinase Activity in Circulating Neutrophils of Patients with Vasospastic Angina after the Great East Japan Earthquake

    Taro Nihei, Jun Takahashi, Yoku Kikuchi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

    CIRCULATION　126　(21)　2012/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  95. Factors Influencing the Higher In-Hospital Mortality of Female Patients with Acute Myocardial Infarction

    Yoshitaka Ito, Jun Takahashi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

    CIRCULATION　126　(21)　2012/11

    ISSN： 0009-7322

    eISSN： 1524-4539

  96. Influence of Coexisting Heart Failure on Non-performance of Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

    Kiyotaka Hao, Jun Takahashi, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　18　(10)　S163-S163　2012/10

    ISSN： 1071-9164

  97. Cessation of Spironolactone Worsens Long-term Prognosis of Heart Failure Patients

    Masaharu Nakayama, Jun Takahashi, Kenta Ito, Yasuharu Matsumoto, Yoshitaka Ito, Ryuji Tsuburaya, Takashi Shiroto, Yusuke Takagi, Kiyotaka Hao, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　18　(10)　S158-S158　2012/10

    ISSN： 1071-9164

  98. 長期的運動が慢性心不全モデルラットの心・腎一酸化窒素合成酵素に及ぼす影響

    伊藤大亮, 伊藤修, 森信芳, 須田千尋, 羽尾清貴, 曹鵬宇, 戒栄, 下川宏明, 上月正博

    日本心臓リハビリテーション学会学術集会プログラム抄録集(Web)　18th　2012

  99. Effect of Exercise Training on Nitric Oxide Synthasesin the Cardiovasculature and Kidney of Rats with Chronic Heart Failure

    Ito, Daisuke, Ito, Osamu, Mori, Nobuyoshi, Suda, Chihiro, Hao, Kiyotaka, Cao, Peng-Yu, Muroya, Yoshikazu, Takashima, Kenta, Shimokawa, Hiroaki, Kohzuki, Masahiro

    J. Card. Fail.　18　(10 1)　S147-S148-S148　2012

    DOI： 10.1016/j.cardfail.2012.08.123 　

    ISSN： 1071-9164

  100. Low-Intensity Pulsed Ultrasound Induces Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Porcine Model of Chronic Myocardial Ischemia

    Kenichiro Hanawa, Satoshi Yasuda, Kentaro Aizawa, Jun-Yi Gao, Ryuji Tsuburaya, Yoku Kikuchi, Kiyotaka Hao, Yoshitaka Ito, Kenta Ito, Hideyuki Hasegawa, Hiroshi Kanai, Hiroaki Shimokawa

    CIRCULATION　124　(21)　2011/11

    ISSN： 0009-7322

  101. Changes in Prevalence and Risk Factors of Acute Myocardial Infarction in the Rural and Urban District in Japan -Report from MIYAGI-AMI Registry Study

    Kiyotaka Hao, Satoshi Yasuda, Toru Takii, Yoshitaka Ito, Akiko Kawana, Jun Takahashi, Morihiko Takeda, Kenta Ito, Hiroaki Shimokawa

    CIRCULATION　124　(21)　2011/11

    ISSN： 0009-7322

  102. Rural and Urban Difference in the Incidence and In-Hospital Mortality of Acute Myocardial Infarction -Report from the MIYAGI-AMI Registry Study-

    Yoshitaka Ito, Satoshi Yasuda, Toru Takii, Kiyotaka Hao, Jun Takahashi, Kenta Ito, Nobuyuki Shiba, Hiroaki Shimokawa

    JOURNAL OF CARDIAC FAILURE　17　(9)　S157-S158　2011/09

    ISSN： 1071-9164

  103. 慢性心不全モデルラットにおける心・腎nitric oxide合成酵素に対する長期的運動の影響

    伊藤 大亮, 伊藤 修, 森 信芳, 須田 千尋, 羽尾 清貴, 曹 鵬宇, 戎 栄, 下川 宏明, 上月 正博

    血管　34　(1)　43-43　2011/01

    Publisher: 日本心脈管作動物質学会

    ISSN： 0911-4637

  104. Exercise Training Increases Nitric Oxide Synthases in the Kidney of Rats with Chronic Heart Failure

    Daisuke Ito, Osamu Ito, Nobuyoshi Mori, Chihiro Suda, Kiyotaka Hao, Peng-yu Cao, Rong Rong, Yoshikazu Muroya, Kenta Takashima, Hiroaki Shimokawa, Masahiro Kohzuki

    HYPERTENSION　58　(5)　E64-E64-E64　2011

    ISSN： 0194-911X

  105. Exercise Training Upregulates Nitric Oxide Synthases in the Kidney of Rats with Chronic Heart Failure

    Daisuke Ito, Osamu Ito, Nobuyoshi Mori, Chihiro Suda, Kiyotaka Hao, Cao Peng-yu, Yoshikazu Muroya, Kenta Takashima, Masahiro Kohzuki

    NITRIC OXIDE-BIOLOGY AND CHEMISTRY　22　(S)　S30-S30-S30　2010

    DOI： 10.1016/j.niox.2010.05.084 　

    ISSN： 1089-8603

  106. PE-361 Prognosis of Extremely Aged Patients (85 years and over) with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

    Aoki Tatsuo, Fukui Akio, Sasaki Shintarou, Hao Kiyotaka, Ohmi Koki, Takahashi Katsuaki, Takahashi Kentaro, Tamada Yoshiaki, Matsui Motoyuki, Yahagi Tomoyasu, Gotoh Toshikazu, Araki Takao

    Circulation journal : official journal of the Japanese Circulation Society　72　450-450　2008/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  107. ペースメーカー植え込みとデノパミン投与を行ったレイノー症状を伴う血管攣縮性狭心症の1例

    羽尾 清貴, 後藤 敏和, 矢作 友保, 松井 幹之, 玉田 芳明, 福井 昭男, 高橋 健太郎, 青木 竜男, 近江 晃樹, 荒木 隆夫, 菅原 重生

    Circulation Journal　71　(Suppl.III)　926-926　2007/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

    eISSN： 1347-4820

  108. 大動脈解離で死亡した若年女性例

    三好 寛明, 高橋 健太郎, 羽尾 清貴, 近江 晃樹, 青木 竜男, 玉田 芳明, 福井 昭男, 松井 幹之, 矢作 友保, 後藤 敏和, 荒木 隆夫

    Circulation Journal　71　(Suppl.III)　927-927　2007/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

    eISSN： 1347-4820

  109. アスペルギルスによる慢性活動性心筋炎の1例

    堀野 智史, 後藤 敏和, 矢作 友保, 松井 幹之, 玉田 芳明, 福井 昭男, 高橋 健太郎, 青木 竜男, 近江 晃樹, 羽尾 清貴, 荒木 隆夫, 笹生 俊一

    Circulation Journal　71　(Suppl.III)　929-929　2007/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

    eISSN： 1347-4820

  110. 心房頻拍と心房粗動を合併し、カテーテルアブレーションを施行した若年WPW症候群の1例

    辻本 雄太, 福井 昭男, 羽尾 清貴, 近江 晃樹, 青木 竜男, 高橋 健太郎, 玉田 芳明, 松井 幹之, 矢作 友保, 後藤 敏和, 荒木 隆夫

    Circulation Journal　71　(Suppl.III)　930-930　2007/10

    Publisher: (一社)日本循環器学会

    ISSN： 1346-9843

    eISSN： 1347-4820

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Research Projects 5

  1. TAVI患者におけるCTと血液オミックス解析による予後予測・個別化治療戦略の構築

    羽尾 清貴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2026/04/01 - 2029/03/31

  2. Clinical characteristics and prognosis of patients with myocardial infarction with non-obstructive coronary artery in Japan

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  3. Clinical impact of 12-lead electrocardigram trasmission system in the management of acute myocardial infarction

    Hao Kiyotaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    To examine the clinical impact of prehospital 12-lead electrocardigram (ECG) transmission system for the management of patients with acute myocardial infarction (AMI), we enrolled the 305 AMI patients in the Osaki and Sennan areas, Miyagi prefecture between 2015 and 2017. Of those, prehospital ECG transmissions were performed in 130 patients (43.3%). In patients with prehospital ECG transmission, as compared with those without it, the prevalence of ST-segment elavation myocardial infarction (STEMI) tended to be higher (80.6% vs. 71.4%, P=0.07). When the patients were divided into STEMI and non-STEMI (NSTEMI) groups, in the STEMI group, door to balloon time (D2BT) was significantly shorter in patients with prehospital ECG compared with those without it [median; 59(47-80) min vs. 73(57-99) min, P<0.01]. In contrast, in the NSTEMI group, there was no significant difference in D2BT between patients with and without prehospital ECG transmission [100(88-180) min vs. 110(75-492) min, P=0.71].

  4. The effect of new generation drug-eluting stent on coronary vasomotion

    Tsuburaya Ryuji, Matsumoto Yasuharu, Hao Kiyotaka, Nishimiya Kensuke, Uzuka Hironori, Ohyama Kazuma, Amamizu Hirokazu, Tuchiya Satoshi, Kikuchi Yoku

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    Although I applied for this research proposal to the ethics committee of our hospital, the ethics committee gave suggestion to start non-randomized observational research. Based on the suggetion, we retrospectively analyzed the vascular response and compared the polymer-absorbable drug-eluting stent (BP-DES) with the non-absorbable drug-eluting stent (DP-DES) for patients who underwent stent deployment in our institution and subsequent coronary spasm provocation testing with acetylcholine after 6-12 months. In the study using OCT, the BP-DES group had a significantly smaller change in Vasa vasorum after placement compared with the DP-DES group. Interestingly, the morphological characters, including lumen and vessel diameter, were similar in the two groups. In addition, we disucussed the protocol about the prospective randomized trial, the ethics comittiee gave us approval in 2018. We have just started patient egistration.

  5. The influence of theThe Great East Japan Earthquake on the emergency care of acute myocardial infarction

    Hao Kiyotaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    We analyzed the data of the Miyagi AMI Registry Study during the period of 2008-2011 (n=3,937) to examine the influence of the Great East Japan Earthquake on the emergency care of acute myocardial infarction. In-hospital mortality of AMI patients was significantly lower in 2011 compared with the previous 3 years (7.3% vs. 10.5%, P<0.05). These results indicate that emergency care of AMI was improved soon after the Earthquake compared with ordinary times, for which improved patient delay and higher performance of primary PCI may be involved.