Details of the Researcher

PHOTO

Masatoshi Suzuki
Section
International Research Institute of Disaster Science
Job title
Specially Appointed Senior Assistant Professor(Research)
Degree

  • M.S. (Nagasaki University)

  • Ph.D. (Nagasaki University)

Professional Memberships 2

  • Radiation Research Society

    2024/01 - Present

  • 日本放射線影響学会

Research Areas 1

  • Life sciences / Radiology /

Papers 78

  1. Development and Performance Evaluation of a Novel Mobile X-ray System for Use in Disaster Situations.

    Masaki Fujisawa, Yohei Inaba, Toshiki Kato, Masatoshi Suzuki, Koichi Chida

    The Tohoku journal of experimental medicine　267　(3)　345-355　2025/12/05

    DOI： 10.1620/tjem.2025.J054 　

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    Mobile radiography is useful for triaging patients during disasters. However, in the face of large-scale disasters, medical equipment, including X-ray systems, may be restricted because of power outages. Therefore, a novel mobile radiography system that can be used in any disaster was developed, and its basic performance was evaluated. This system is designed for use during power outages and can be recharged using both household and solar power sources. The reproducibility of the X-ray output of the system (irradiation dose, tube voltage, radiation quality and irradiation time) was excellent, confirming that radiography could be performed consistently. The entrance surface dose and scattered radiation during chest radiography were measured using a chest phantom. Both results were acceptable, verifying that the system is sufficiently safe from the viewpoint of radiation protection. This novel mobile radiology system is easy to carry and can generate solar power, making it useful during a power outage in the case of a large-scale disaster or when examinations need to be performed outside a hospital, such as at a first-aid station.

  2. 低濃度持続処理によるヒト細胞内へのトリチウムの取り込み・局在とDNA二重鎖切断誘発との関連性 Peer-reviewed

    和泉哉汰, 磯部理央, 佐藤拓, 山下琢磨, 木野康志, 福本学, 鈴木正敏, 千田浩一

    Proceedings of the 26th Workshop on Environmental Radioactivity　2025　(2)　89-94　2025/12

  3. 福島県内の土壌から採取した不溶性セシウム粒子による細胞影響解析 Peer-reviewed

    鈴木正敏, 遠藤暁, 二宮和彦, 真辺健太郎, 佐藤拓, 和泉哉汰, 千田浩一, 福本学

    Proceedings of the 26th Workshop on Environmental Radioactivity　2025　(2)　2025/12

  4. ニホンザル歯中炭酸ラジカルの電子スピン共鳴法測定におけるマイクロ波パワーの最適化 Peer-reviewed

    林哲平, 山下琢磨, 光安優典, 小野健太, 岩見聡音, 岡壽崇, 高橋温, 木野康志, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 佐藤拓, 鈴木正敏, 福本学, 篠田壽

    Proceedings of the 26th Workshop on Environmental Radioactivity　2025　(2)　2025/12

  5. 福島県浜通りで捕獲されたニホンザル臓器中の放射性セシウム濃度の測定 Peer-reviewed

    長原辰弥, 尾田晃平, 林哲平, 木野康志, 山下琢磨, 石川諒椰, 佐藤拓, 和泉哉汰, 鈴木正敏, 千田浩一, 福本学

    Proceedings of the 26th Workshop on Environmental Radioactivity　2025　(2)　48-53　2025/12

  6. 福島第一原発事故に被災した野生ニホンザルの外部被ばく評価と血漿における酸化ストレス状態解析 Peer-reviewed

    佐藤拓, 石川諒椰, 和泉哉汰, 尾田晃平, 林哲平, 長原辰弥, 山下琢磨, 木野康志, 遠藤暁, 鈴木敏彦, 篠田壽, 福本学, 鈴木正敏, 千田浩一

    Proceedings of the 26th Workshop on Environmental Radioactivity　2025　(2)　95-100　2025/12

  7. Evaluation of radiation protection by lead glasses for interventional radiology physicians wearing prescription glasses: considering dose reduction by prescription glasses excluding lead. International-journal

    Ryota Shindo, Keisuke Yamamoto, Saya Ohno, Satoe Konta, Yohei Inaba, Masatoshi Suzuki, Masayuki Zuguchi, Koichi Chida

    Journal of radiation research　66　(5)　486-495　2025/09/23

    DOI： 10.1093/jrr/rraf047 　

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    The International Commission on Radiological Protection has reduced the occupational eye lens dose limit to 20 mSv/year. Interventional radiology (IR) physicians are frequently exposed to high levels of scattered X-rays, and radiation protection tools, including lead glasses, are used for minimizing exposure. However, the effectiveness of lead eyewear for radiation workers who wear prescription glasses (e.g. over-glasses-type eyewear) has not been comprehensively investigated. This study evaluated the shielding effectiveness of over-glasses-type eyewear worn over plastic prescription glasses through phantom experiments. Furthermore, the dose reduction provided by the plastic lenses and front frame of the prescription glasses (excluding lead) was assessed. The over-glasses-type eyewear demonstrated high shielding effectiveness, with average shielding rates of 0.72-0.74 and 0.74-0.80 for the left and right eyes, respectively, against radiation incident from the lower left oblique, as typically encountered in clinical settings. In contrast, the plastic lenses of prescription glasses provided <9% dose reduction when it irradiated with 80- and 120-kV X-rays, indicating minimal contribution to eye protection. The plastic front frame offered a 14% reduction at 80 kV and 11% at 120 kV. These findings suggest that the front frame of the prescription glasses contributes to photon attenuation and improves overall shielding. However, the improper fit of over-glasses-type eyewear may lead to gaps, compromising its shielding effectiveness. To minimize gaps and optimize protection, IR physicians should select over-glasses-type eyewear that fits securely over prescription glasses. Additionally, combining protective tools is essential for effective eye protection.

  8. Optimization of microwave power in ESR dosimetry of tooth enamel in Japanese macaques

    Teppei Hayashi, Takuma Yamashita, Yusuke Mitsuyasu, Kenta Ono, Satone Iwami, Yasushi Kino, Tsutomu Sekine, Toshitaka Oka, Atsushi Takahashi, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Taku Sato, Rio Isobe, Masatoshi Suzuki, Tomisato Miura, Manabu Fukumoto, Hisashi Shinoda

    International Journal of Radiation Biology　1-8　2025/08/08

    Publisher: Informa UK Limited

    DOI： 10.1080/09553002.2025.2534998 　

    ISSN： 0955-3002

    eISSN： 1362-3095

  9. Development of a headgear-based eye protection device for physicians performing fluoroscopy-guided bronchoscopy. International-journal

    Masaki Fujisawa, Yoshihiro Haga, Saki Takahira, Masahiro Sota, Toshiki Kato, Mitsuya Abe, Yuji Kaga, Yohei Inaba, Masatoshi Suzuki, Koichi Chida

    Journal of radiation research　2025/06/18

    DOI： 10.1093/jrr/rraf031 　

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    Fluoroscopy-guided bronchoscopy is an essential tool for diagnosing and treating lung diseases, particularly lung cancer. However, prolonged fluoroscopic exposure raises concerns regarding radiation-induced lens injuries in physicians, such as radiation cataracts. In response to the International Commission on Radiological Protection lowering the occupational lens dose limit to an average of 20 mSv/year over 5 years, there is an increasing need for effective lens protection during such procedures. This study has aimed to develop a novel lens protection device specifically designed for bronchoscopy physicians and evaluate its protective performance through a phantom study. The device consisted of a 0.175 mm lead (Pb) sheet positioned on the left side of the physician's head, secured with headgear to improve stability and comfort during prolonged use. A phantom study was conducted using a trunk phantom to simulate a patient and a head phantom to simulate a physician. The scattered radiation doses were measured at 15 locations on the phantom head using a radiophotoluminescence glass dosimeter, both with and without a protective device. The device demonstrated a protective effect of more than 80% for the left eye across all tested angles, whereas the right eye showed protection ranging from approximately 40% to 75% depending on the angle. This novel lens protection device has the potential to significantly reduce scattered radiation to the left eye while minimizing vision obstruction and discomfort. This offers a practical solution for radiation protection during bronchoscopy and may be applicable to other interventional procedures requiring fluoroscopic guidance.

  10. Development of an electron spin resonance spectroscopy code for measuring carbonate radicals in tooth enamel and verification of its practicality using irradiated Japanese macaque teeth

    Takuma Yamashita, Teppei Hayashi, Yusuke Mitsuyasu, Kenta Ono, Satone Iwami, Yasushi Kino, Tsutomu Sekine, Toshitaka Oka, Atsushi Takahashi, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Taku Sato, Rio Isobe, Masatoshi Suzuki, Tomisato Miura, Manabu Fukumoto, Hisashi Shinoda

    International Journal of Radiation Biology　1-8　2025/06/09

    Publisher: Informa UK Limited

    DOI： 10.1080/09553002.2025.2510676 　

    ISSN： 0955-3002

    eISSN： 1362-3095

  11. Establishment of acquired radioresistant cells to fractionated radiation from hTERT-immortalized normal human epithelial cell

    Masatoshi Suzuki, Rio Isobe, Taku Sato, Ryoya Ishikawa, Keiji Suzuki, Yasushi Kino, Tomisato Miura, Yohei Inaba, Koichi Chida, Manabu Fukumoto

    Radiation Protection Dosimetry　200　(16-18)　1636-1640　2024/11/01

    DOI： 10.1093/rpd/ncae118 　

    ISSN： 0144-8420

    eISSN： 1742-3406

  12. Analysis of cellular effects by continuous exposure AT low concentration of tritium

    Rio Isobe, Masatoshi Suzuki, Satoru Endo, Yasushi Kino, Ryoya Ishikawa, Yohei Inaba, Manabu Fukumoto, Koichi Chida

    Radiation Protection Dosimetry　200　(16-18)　1631-1635　2024/11/01

    DOI： 10.1093/rpd/ncae112 　

    ISSN： 0144-8420

    eISSN： 1742-3406

  13. Improved multicomponent analysis method for electron spin resonance spectra of gamma-irradiated tooth enamel

    山下琢磨, 山下琢磨, 岩見聡音, 光安優典, 小野健太, 岡壽崇, 高橋温, 木野康志, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 佐藤拓, 礒部理央, 鈴木正敏, 福本学, 福本学, 篠田壽

    KEK Proceedings (Web)　(2024-6)　2024

  14. Study on microwave power dependency of electron spin resonance spectrum of carbonate radicals in teeth

    岩見聡音, 山下琢磨, 山下琢磨, 光安優典, 小野健太, 岡壽崇, 高橋温, 木野康志, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 佐藤拓, 礒部理央, 鈴木正敏, 福本学, 福本学, 篠田壽

    KEK Proceedings (Web)　(2024-6)　2024

  15. シンチレータ式簡易測定器の諸特性に関する基礎検討

    礒部 理央, 古川 未来, 大野 紗耶, 進藤 遼太, 山本 啓介, 稲葉 洋平, 鈴木 正敏, 千田 浩一

    日本放射線安全管理学会誌　22　(2)　72-82　2023/11

    Publisher: (一社)日本放射線安全管理学会

    ISSN： 1347-1503

  16. シンチレータ式簡易測定器の諸特性に関する基礎検討

    礒部 理央, 古川 未来, 大野 紗耶, 進藤 遼太, 山本 啓介, 稲葉 洋平, 鈴木 正敏, 千田 浩一

    日本放射線安全管理学会誌　22　(2)　72-82　2023/11

    Publisher: (一社)日本放射線安全管理学会

    ISSN： 1347-1503

  17. Internal organ dose rate conversion coefficients of Japanese macaques to 134Cs,137Cs and 131I†. International-journal

    Yuta Takamura, Tsuyoshi Kajimoto, Kenichi Tanaka, Tomoya Yamamoto, Masatoshi Suzuki, Yohei Inaba, Koichi Chida, Manabu Fukumoto, Chary Rangacharyulu, Satoru Endo

    Journal of radiation research　64　(5)　804-810　2023/09/22

    DOI： 10.1093/jrr/rrad055 　

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    The purpose of this study was to estimate the internal dose of radiation in Japanese macaques (aka Nihonzaru or snow monkey) due to the Fukushima nuclear power plant accident. Images of a male Japanese macaque weighing ~10 kg were acquired using a multi-slice computed tomography (CT) scan with a 64-row segment detector. The CT images were used to create voxel phantoms of the bones, bone marrow, brain, eyes, heart, lungs, stomach, liver, spleen, pancreas, kidneys, intestines, bladder, testes, thyroid and miscellaneous tissue. The Particle and Heavy Ion Transport System (PHITS) Monte Carlo code was used to calculate the internal exposure rate conversion factors for 134Cs, 137Cs and 131I isotopes for the created voxel phantoms with a statistical precision higher than 1%. The PHITS-calculated energy deposits were compared with those for rhesus monkeys. The results showed that the fractions of energy deposits for β-radiation in different organs were almost identical between the two species. For γ-radiation, there was excellent agreement in the self-absorption rate with the approximate curve of the Japanese macaque, with an average deviation of 2%. The maximum deviation of 12% was for the kidney, which has two organs, so the error with the approximate curve is slightly larger due to the energy loss created between organs.

  18. Eye Lens Radiation Dose to Nurses during Cardiac Interventional Radiology: An Initial Study. International-journal

    Ayumi Yamada, Yoshihiro Haga, Masahiro Sota, Mitsuya Abe, Yuji Kaga, Yohei Inaba, Masatoshi Suzuki, Norio Tada, Masayuki Zuguchi, Koichi Chida

    Diagnostics (Basel, Switzerland)　13　(18)　2023/09/20

    DOI： 10.3390/diagnostics13183003 　

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    Although interventional radiology (IVR) is preferred over surgical procedures because it is less invasive, it results in increased radiation exposure due to long fluoroscopy times and the need for frequent imaging. Nurses engaged in cardiac IVR receive the highest lens radiation doses among medical workers, after physicians. Hence, it is important to measure the lens exposure of IVR nurses accurately. Very few studies have evaluated IVR nurse lens doses using direct dosimeters. This study was conducted using direct eye dosimeters to determine the occupational eye dose of nurses engaged in cardiac IVR, and to identify simple and accurate methods to evaluate the lens dose received by nurses. Over 6 months, in a catheterization laboratory, we measured the occupational dose to the eyes (3 mm dose equivalent) and neck (0.07 mm dose equivalent) of nurses on the right and left sides. We investigated the relationship between lens and neck doses, and found a significant correlation. Hence, it may be possible to estimate the lens dose from the neck badge dose. We also evaluated the appropriate position (left or right) of eye dosimeters for IVR nurses. Although there was little difference between the mean doses to the right and left eyes, that to the right eye was slightly higher. In addition, we investigated whether it is possible to estimate doses received by IVR nurses from patient dose parameters. There were significant correlations between the measured doses to the neck and lens, and the patient dose parameters (fluoroscopy time and air kerma), implying that these parameters could be used to estimate the lens dose. However, it may be difficult to determine the lens dose of IVR nurses accurately from neck badges or patient dose parameters because of variation in the behaviors of nurses and the procedure type. Therefore, neck doses and patient dose parameters do not correlate well with the radiation eye doses of individual IVR nurses measured by personal eye dosimeters. For IVR nurses with higher eye doses, more accurate measurement of the radiation doses is required. We recommend that a lens dosimeter be worn near the eyes to measure the lens dose to IVR nurses accurately, especially those exposed to relatively high doses.

  19. Estimation of external dose for wild Japanese macaques captured in Fukushima prefecture: decomposition of electron spin resonance spectrum

    Yusuke Mitsuyasu, Toshitaka Oka, Atsushi Takahashi, Yasushi Kino, Kenichi Okutsu, Tsutomu Sekine, Takuma Yamashita, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Masatoshi Suzuki, Manabu Fukumoto, Hisashi Shinoda

    Radiation Protection Dosimetry　199　(14)　1620-1625　2023/09/18

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/rpd/ncad146 　

    ISSN： 0144-8420

    eISSN： 1742-3406

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    Abstract The signal intensities of CO2− radicals in teeth can be utilised as an individual indicator of the cumulative external dose for animals. To accurately determine the external dose, it is desirable to analyse the CO2− radical intensity and improve its detection limit. We recently reported a dose–response in the range of 0–200 mGy and estimated the absorbed dose for seven wild Japanese macaques captured in/around the related areas to the Fukushima Daiichi Nuclear Power Plant accident. Herein, for further improvement of this method, we examined the electron spin resonance spectra of the teeth of these seven and an additional four macaques captured in Fukushima by applying two spectrum-decomposition algorithms.

  20. Evaluation of Lens Doses among Medical Staff Involved in Nuclear Medicine: Current Eye Radiation Exposure among Nuclear-Medicine Staff Peer-reviewed

    Masaki Fujisawa, Yoshihiro Haga, Masahiro Sota, Mitsuya Abe, Yuji Kaga, Yohei Inaba, Masatoshi Suzuki, Taiichiro Meguro, Yoshio Hosoi, Koichi Chida

    Applied Sciences　13　(16)　9182-9182　2023/08/12

    Publisher: MDPI AG

    DOI： 10.3390/app13169182 　

    eISSN： 2076-3417

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    The International Commission on Radiological Protection has lowered the annual equivalent eye-lens dose to 20 mSv. Although occupational exposure can be high in nuclear medicine (NM) departments, few studies have been conducted regarding eye-lens exposure among NM staff. This study aimed to estimate the annual lens doses of staff in an NM department and identify factors contributing to lens exposure. Four nurses and six radiographers performing positron emission tomography (PET) examinations and four radiographers performing radioisotope (RI) examinations (excluding PET) were recruited for this study. A lens dosimeter was attached near the left eye to measure the 3-mm-dose equivalent; a personal dosimeter was attached to the left side of the neck to measure the 1-cm- and 70-µm-dose equivalents. Measurements were acquired over six months, and the cumulative lens dose was doubled to derive the annual dose. Correlations between the lens and personal-dosimeter doses, between the lens dose and the numbers of procedures, and between the lens dose and the amounts of PET drugs (radiopharmaceuticals) injected were examined. Wilcoxon’s signed-rank test was used to compare lens and personal-dosimeter doses. The estimated annual doses were 0.93 ± 0.13 mSv for PET nurses, 0.71 ± 0.41 mSv for PET radiographers, and 1.10 ± 0.53 mSv for RI radiographers. For PET nurses, but not for PET or RI radiographers, there was a positive correlation between the numbers of procedures and lens doses and between amounts injected and lens doses. There was a significant difference between the lens and personal-dosimeter doses of PET nurses. The use of protective measures, such as shielding, should prevent NM staff from receiving lens doses &gt; 20 mSv/year. However, depending on the height of the protective shield, PET nurses may be unable to assess the lens dose accurately using personal dosimeters.

  21. Spatial Scattering Radiation to the Radiological Technologist during Medical Mobile Radiography. International-journal

    Kazuki Otomo, Yohei Inaba, Keisuke Abe, Mana Onodera, Tomohiro Suzuki, Masahiro Sota, Yoshihiro Haga, Masatoshi Suzuki, Masayuki Zuguchi, Koichi Chida

    Bioengineering (Basel, Switzerland)　10　(2)　2023/02/16

    DOI： 10.3390/bioengineering10020259 　

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    Mobile radiography allows for the diagnostic imaging of patients who cannot move to the X-ray examination room. Therefore, mobile X-ray equipment is useful for patients who have difficulty with movement. However, staff are exposed to scattered radiation from the patient, and they can receive potentially harmful radiation doses during radiography. We estimated occupational exposure during mobile radiography using phantom measurements. Scattered radiation distribution during mobile radiography was investigated using a radiation survey meter. The efficacy of radiation-reducing methods for mobile radiography was also evaluated. The dose decreased as the distance from the X-ray center increased. When the distance was more than 150 cm, the dose decreased to less than 1 μSv. It is extremely important for radiological technologists (RTs) to maintain a sufficient distance from the patient to reduce radiation exposure. The spatial dose at eye-lens height increases when the bed height is high, and when the RT is short in stature and abdominal imaging is performed. Maintaining sufficient distance from the patient is also particularly effective in limiting radiation exposure of the eye lens. Our results suggest that the doses of radiation received by staff during mobile radiography are not significant when appropriate radiation protection is used. To reduce exposure, it is important to maintain a sufficient distance from the patient. Therefore, RTs should bear this is mind during mobile radiography.

  22. PET検査に従事する看護師の水晶体被ばく線量に関する基礎検討

    藤沢 昌輝, 芳賀 善裕, 曽田 真宏, 加賀 勇治, 阿部 美津也, 稲葉 洋平, 鈴木 正敏, 細井 義夫, 千田 浩一

    臨床放射線　67　(10)　1075-1083　2022/10

    Publisher: 金原出版(株)

    ISSN： 0009-9252

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    PET検査に従事する看護師4人の水晶体被ばく線量を評価した。水晶体用線量計DOSIRISとガラスバッジによる水晶体被ばく線量、従事した検査数、PET薬剤の投与量を調査した。その結果、左眼水晶体近傍にDOSIRISを装着して測定した3mm線量当量から算出した年間水晶体等価線量は0.93±0.13mSv、ガラスバッジでは0.66±0.17mSvであり、DOSIRISとガラスバッジの線量に十分な相関はなかったが、DOSIRISおよびガラスバッジの線量と、看護師の従事件数、薬剤投与量にはそれぞれ相関がみられた。本研究では年間のPET検査従事件数が推定568件であったことより、看護師が線量限度の20mSv/年を超過する可能性は低いと考えられるが、従事件数や薬剤投与量によっては水晶体の線量が高くなることが予想され、看護師のPET検査従事件数を減らすことが有効な水晶被ばく低減策といえる。

  23. A study on accuracy of analysis of the radiation-induced component in the ESR spectra of teeth

    光安優典, 岡壽崇, 高橋温, 木野康志, 奥津賢一, 関根勉, 山下琢磨, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 鈴木正敏, 福本学, 篠田壽

    KEK Proceedings (Web)　(2022-2)　2022

  24. Radiation exposure and oxidative stress status of wild Japanese macaques in the ex-evacuation zone of the Fukushima Daiichi Nuclear Power Plant accident

    石川諒椰, 鈴木正敏, 鈴木正敏, 木野康志, 遠藤暁, 中島裕夫, 岡壽崇, 高橋温, 清水良央, 鈴木敏彦, 篠田壽, 山下琢磨, 山下琢磨, 奥津賢一, 福本学, 福本学, 千田浩一, 千田浩一

    KEK Proceedings (Web)　(2022-2)　2022

  25. Non-Lead Protective Aprons for the Protection of Interventional Radiology Physicians from Radiation Exposure in Clinical Settings: An Initial Study. International-journal

    Mamoru Kato, Koichi Chida, Masato Munehisa, Tadaya Sato, Yohei Inaba, Masatoshi Suzuki, Masayuki Zuguchi

    Diagnostics (Basel, Switzerland)　11　(9)　2021/09/03

    DOI： 10.3390/diagnostics11091613 　

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    Radiation protection/evaluation during interventional radiology (IVR) poses a very important problem. Although IVR physicians should wear protective aprons, the IVR physician may not tolerate wearing one for long procedures because protective aprons are generally heavy. In fact, orthopedic problems are increasingly reported in IVR physicians due to the strain of wearing heavy protective aprons during IVR. In recent years, non-Pb protective aprons (lighter weight, composite materials) have been developed. Although non-Pb protective aprons are more expensive than Pb protective aprons, the former aprons weigh less. However, whether the protective performance of non-Pb aprons is sufficient in the IVR clinical setting is unclear. This study compared the ability of non-Pb and Pb protective aprons (0.25- and 0.35-mm Pb-equivalents) to protect physicians from scatter radiation in a clinical setting (IVR, cardiac catheterizations, including percutaneous coronary intervention) using an electric personal dosimeter (EPD). For radiation measurements, physicians wore EPDs: One inside a personal protective apron at the chest, and one outside a personal protective apron at the chest. Physician comfort levels in each apron during procedures were also evaluated. As a result, performance (both the shielding effect (98.5%) and comfort (good)) of the non-Pb 0.35-mm-Pb-equivalent protective apron was good in the clinical setting. The radiation-shielding effects of the non-Pb 0.35-mm and Pb 0.35-mm-Pb-equivalent protective aprons were very similar. Therefore, non-Pb 0.35-mm Pb-equivalent protective aprons may be more suitable for providing radiation protection for IVR physicians because the shielding effect and comfort are both good in the clinical IVR setting. As non-Pb protective aprons are nontoxic and weigh less than Pb protective aprons, non-Pb protective aprons will be the preferred type for radiation protection of IVR staff, especially physicians.

  26. Morphological reproductive characteristics of testes and fertilization capacity of cryopreserved sperm after the Fukushima accident in raccoon (Procyon lotor). International-journal

    Kazuki Komatsu, Tsugumi Iwasaki, Kosuke Murata, Hideaki Yamashiro, Valerie Swee Ting Goh, Ryo Nakayama, Yohei Fujishima, Takumi Ono, Yasushi Kino, Yoshinaka Simizu, Atsushi Takahashi, Hisashi Shinoda, Kentaro Ariyoshi, Kosuke Kasai, Masatoshi Suzuki, Maria Grazia Palmerini, Manuel Belli, Guido Macchiarelli, Toshitaka Oka, Manabu Fukumoto, Mitsuaki A Yoshida, Akifumi Nakata, Tomisato Miura

    Reproduction in domestic animals = Zuchthygiene　56　(3)　484-497　2021/03

    DOI： 10.1111/rda.13887 　

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    Since the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, we have established an archive system of livestock and wild animals from the surrounding ex-evacuation zone. Wildlife within the alert zone have been exposed to low-dose-rate (LDR) radiation for a long continuous time. In this study, we analysed the morphological characteristics of the testes and in vitro fertilization (IVF) capacity of cryopreserved sperm of racoons from the ex-evacuation zone of the FDNPP accident. The radioactivity of caesium-137 (137 Cs) was measured by gamma-ray spectrometry, and the measured radioactivity concentration was 300-6,630 Bq/kg in the Fukushima raccoons. Notably, normal spermatogenesis was observed in the seminiferous tubules of the testes, with the germinal epithelium composed of a spermatogenic cell lineage with no evident ultrastructural alterations; freeze-thawing sperm penetration ability was confirmed using the interspecific zona pellucida-free mouse oocytes IVF assays. This study revealed that the chronic and LDR radiation exposure associated with the FDNPP accident had no adverse effect on the reproductive characteristics and functions of male raccoons.

  27. Development of dose estimation method using wild animal teeth for low dose exposure

    光安優典, 岡壽崇, 高橋温, 小荒井一真, 木野康志, 奥津賢一, 関根勉, 山下琢磨, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 漆原佑介, 鈴木正敏, 福本学, 篠田壽

    KEK Proceedings (Web)　(2021-2)　2021

  28. 低線量被ばくをした野生動物の歯を用いた被ばく線量推定

    光安 優典, 岡 壽崇, 高橋 温, 小荒井 一真, 木野 康志, 奥津 賢一, 関根 勉, 山下 琢磨, 清水 良央, 千葉 美麗, 鈴木 敏彦, 小坂 健, 佐々木 啓一, 漆原 佑介, 鈴木 正敏, 福本 学, 篠田 壽

    アイソトープ・放射線研究発表会　1　101　2021

    Publisher: 公益社団法人 日本アイソトープ協会

    DOI： 10.50955/happyokai.1.0_101 　

    eISSN： 2436-4487

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    福島原発事故によっておきた環境汚染による被ばくは、これまで知見の少ない領域である。我々は野生動物を用いて生体への影響調査を行っている。行動履歴の不明な野生動物の被ばく線量を推定するために、被ばく量に依存して歯の中に生成、蓄積されるラジカルを電子スピン共鳴（ESR）測定にて測定する手法に着目した。現在、動物の低線量被ばくに適用させるため改良した新手法を開発しており、現段階での測定精度と実際の推定線量被ばく線量について報告する。

  29. Estimating the exposure dose of wild raccoons for investigation of radiobiological effects after the Fukushima Daiichi accident

    小野拓実, 木野康志, 清水良央, 高橋温, 高橋温, 藤嶋洋平, GOH Varerie Swee Ting, 有吉健太郎, 中田章史, 鈴木正敏, 中川貴美子, 高橋常男, 山田良広, 遠藤暁, 山城秀昭, 関根勉, 関根勉, 篠田壽, 三浦富智

    KEK Proceedings (Web)　(2021-2)　2021

  30. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ 福島県浪江町に生息する野生動物の臓器の放射性セシウム濃度測定と内部被ばく線量推定(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Radioactive cesium concentration measurements and internal exposure dose rates estimation for wild animals in Namie Town, Fukushima)

    小野 拓実, 木野 康志, 高橋 温, 鈴木 敏彦, 清水 良央, 千葉 美麗, 藤嶋 洋平, Goh Valerie, 有吉 健太郎, 中田 章史, 鈴木 正敏, 山城 秀昭, 関根 勉, 篠田 壽, 三浦 富智

    日本放射線影響学会大会講演要旨集　63回　39-39　2020/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  31. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ 福島県の放射線汚染地域に生息する種々の野生動物における染色体解析(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Assessment of chromosome aberrations in wild animals in Fukushima)

    藤嶋 洋平, 中田 章史, Goh Valerie, 葛西 宏介, 有吉 健太郎, 鈴樹 亨純, 山城 秀昭, 篠田 壽, 鈴木 正敏, 吉田 光明, 三浦 富智

    日本放射線影響学会大会講演要旨集　63回　40-40　2020/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  32. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ 被災アライグマにおける生殖機能への影響評価(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Morphological reproductive characteristics of gonad and fertilization capacity of raccoon(Procyon lotor) cryopreserved sperm after the Fukushima accident)

    岩崎 亜美, 村田 康輔, 山城 秀昭, Goh Valerie, 中山 亮, 藤嶋 洋平, 小野 拓実, 木野 康志, 清水 良央, 高橋 温, 篠田 壽, 有吉 健太郎, 葛西 宏介, 鈴木 正敏, 福本 学, 吉田 光明, 中田 章史, 三浦 富智

    日本放射線影響学会大会講演要旨集　63回　40-40　2020/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  33. 福島原発事故による周辺生物への影響調査研究 福島原発事故による動物・環境試料を用いた放射線被ばく影響解析(Radiation effects on non-human biota after the Fukushima nuclear power plant accident Comprehensive analysis of radiation effects using disaster affected animal and environmental samples of Fukushima Dai-ichi nuclear power plant accident)

    鈴木 正敏, 遠藤 暁, 松谷 祐輝, 岡 壽崇, 小野 拓実, 光安 優典, 木野 康志, 高橋 温, 篠田 壽, 漆原 佑介, 中島 裕夫, 二宮 和彦, 三浦 富智, 稲葉 洋平, 千田 浩一, 福本 学

    日本放射線影響学会大会講演要旨集　63回　38-38　2020/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  34. 野生動物と実験動物を用いた放射線生物影響解明のための多元的アプローチ 福島県浪江町に生息する野生動物の臓器の放射性セシウム濃度測定と内部被ばく線量推定(Pluralistic approach to elucidating radiobiological effects using wild and experimental animals Radioactive cesium concentration measurements and internal exposure dose rates estimation for wild animals in Namie Town, Fukushima)

    小野 拓実, 木野 康志, 高橋 温, 鈴木 敏彦, 清水 良央, 千葉 美麗, 藤嶋 洋平, Goh Valerie, 有吉 健太郎, 中田 章史, 鈴木 正敏, 山城 秀昭, 関根 勉, 篠田 壽, 三浦 富智

    日本放射線影響学会大会講演要旨集　63回　39-39　2020/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  35. External exposure dose estimation by electron spin resonance technique for wild Japanese macaque captured in Fukushima Prefecture Peer-reviewed

    Toshitaka Oka, Atsushi Takahashi, Kazuma Koarai, Yusuke Mitsuyasu, Yasushi Kino, Tsutomu Sekine, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Yusuke Urushihara, Satoru Endo, Masatoshi Suzuki, Hisashi Shinoda, Manabu Fukumoto

    Radiation Measurements　134　106315-106315　2020/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.radmeas.2020.106315 　

    ISSN： 1350-4487

  36. Correlation of Radiocesium Activity between Muscle and Peripheral Blood of Live Cattle Depending on Presence or Absence of Radiocontamination in Feed. International-journal Peer-reviewed

    Suzuki M, Suzuki H, Ishiguro H, Saito Y, Watanabe S, Kozutsumi T, Sochi Y, Nishi K, Urushihara Y, Kino Y, Numabe T, Sekine T, Chida K, Fukumoto M

    Radiation Research　192　(6)　589-601　2019/12

    DOI： 10.1667/RR15418.1 　

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    To monitor radiocesium activity in skeletal muscle of live cattle, the animals were given radiocesium-contaminated feed continuously, then switched to contamination-free feed after radiocecium concentration in peripheral blood (PB) reached plateau. Radioactivity in skeletal muscles of neck and rump was measured by attaching the probe of a NaI survey meter closely on the body surface just above the muscle of the live cattle (external measurement). We validated the strong positive correlation between the value of the external measurement and radiocesium activity concentration of dissected muscle (r = 0.89, P < 0.001 for neck; r = 0.80, P < 0.001 for rump). Accumulation of radiocesium both in muscle and PB was proportional to the total amount of radiocesium cattle ingested. However, radioactivity concentration in PB was constant in the cattle that had continuously ingested radiocesium, lower than 2.0 × 105 Bq in total within 67 days from the beginning of radiocesium intake. In addition, the ratio of radiocesium activity in muscle to that in PB was lower during the time when radiocontaminated feed was ingested than that of contamination-free feed ingestion. Using the correlation of radioactivity between muscle and PB, we confirmed that a majority of the cattle in the ex-evacuation zone of the Fukushima Daiichi nuclear power plant accident, from 167 to 365 days after the accident occurred, were in the declining period of radiocesium intake.

  37. 福島県で捕獲したニホンザルの電子スピン共鳴法による外部被ばく線量推定

    岡 壽崇, 高橋 温, 小荒井 一真, 光安 優典, 木野 康志, 関根 勉, 清水 良央, 千葉 美麗, 鈴木 敏彦, 小坂 健, 佐々木 啓一, 漆原 佑介, 鈴木 正敏, 篠田 壽, 福本 学

    日本分析化学会講演要旨集　68年会　268-268　2019/08

    Publisher: (公社)日本分析化学会

  38. MiR-7-5p is a key factor that controls radioresistance via intracellular Fe2+ content in clinically relevant radioresistant cells. International-journal Peer-reviewed

    Kazuo Tomita, Manabu Fukumoto, Katsuhiko Itoh, Yoshikazu Kuwahara, Kento Igarashi, Taisuke Nagasawa, Masatoshi Suzuki, Akihiro Kurimasa, Tomoaki Sata

    Biochemical and Biophysical Research Communications.　in press　(4)　712-718　2019/08

    DOI： 10.1016/j.bbrc.2019.08.117 　

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    MicroRNA (miRNA) is a non-coding RNA involved in regulating both cancer gene promotion and suppression. We investigated the role of miRNA in inducing radiation resistance in cancer cell lines using clinically relevant radioresistant (CRR) cells. Analysis using miRNA arrays and qPCR revealed that miR-7-5p is highly expressed in all examined CRR cells. Additionally, CRR cells lose their radioresistance when daily irradiation is interrupted for over 6 months. MiR-7-5p expression is reduced in these cells, and treating CRR cells with a miR-7-5p inhibitor leads to a loss of resistance to irradiation. Conversely, overexpression of miR-7-5p in CRR cells using a miR-7-5p mimic shows further resistance to radiation. Overexpression of miR-7-5p in parent cells also results in resistance to radiation. These results indicate that miR-7-5p may control radioresistance in various cancer cells at the clinically relevant dose of irradiation. Furthermore, miR-7-5p downregulates mitoferrin and reduces Fe2+, which influences ferroptosis. Our findings have great potential not only for examining radiation resistance prior to treatment but also for providing new therapeutic agents for treatment-resistant cancers.

  39. Evaluation of exposure dose and distribution of radionuclides in wildlife for investigation of radiation effect of Fukushima nuclear accident

    小野拓実, 小荒井一真, 木野康志, 田巻廣明, 岡壽崇, 岡壽崇, 高橋温, 鈴木敏彦, 鈴木敏彦, 清水良央, 千葉美麗, 藤嶋洋平, TING Valerie Goh Swee, 有吉健太郎, 中田章史, 鈴木正敏, 山城秀昭, 福本学, 関根勉, 関根勉, 篠田壽, 三浦富智, 三浦富智

    KEK Proceedings (Web)　(2019-2)　2019

  40. 福島第一原発事故被災サルの歯・骨へのSr-90の取り込み履歴と骨髄線量の推定

    小荒井 一真, 木野 康志, 西山 純平, 金子 拓, 小野 拓実, 岡 壽崇, 高橋 温, 鈴木 敏彦, 清水 良央, 千葉 美麗, 小坂 健, 佐々木 啓一, 漆原 佑介, 鈴木 正敏, 関根 勉, 篠田 壽, 福本 学

    日本放射線影響学会大会講演要旨集　61回　67-67　2018/11

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  41. ニホンザルの歯の電子スピン共鳴測定による外部被ばく線量推定

    岡 壽崇, 高橋 温, 小荒井 一真, 木野 康志, 関根 勉, 清水 良央, 千葉 美麗, 鈴木 敏彦, 小坂 健, 佐々木 啓一, 鈴木 正敏, 篠田 壽, 福本 学

    日本放射線影響学会大会講演要旨集　61回　100-100　2018/11

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  42. 福島第一原子力事故被災サル硬組織中の放射能濃度

    金子 拓, 小荒井 一真, 木野 康志, 西山 純平, 岡 壽崇, 高橋 温, 鈴木 敏彦, 清水 良央, 千葉 美麗, 小坂 健, 佐々木 啓一, 漆原 佑介, 鈴木 正敏, 関根 勉, 篠田 壽, 福本 学

    Proceedings of the 19th Workshop on Environmental Radioactivity　2018-7　231-236　2018/11

  43. Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident Peer-reviewed

    Yusuke Urushihara, Toshihiko Suzuki, Yoshinaka Shimizu, Megu Ohtaki, Yoshikazu Kuwahara, Masatoshi Suzuki, Takeharu Uno, Shiori Fujita, Akira Saito, Hideaki Yamashiro, Yasushi Kino, Tsutomu Sekine, Hisashi Shinoda, Manabu Fukumoto

    Scientific Reports　8　(1)　16748　2018/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-018-35104-0 　

    eISSN： 2045-2322

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    Several populations of wild Japanese macaques (Macaca fuscata) inhabit the area around Fukushima Daiichi Nuclear Power Plant (FNPP). To measure and control the size of these populations, macaques are captured annually. Between May 2013 and December 2014, we performed a haematological analysis of Japanese macaques captured within a 40-km radius of FNPP, the location of a nuclear disaster two years post-accident. The dose-rate of radiocaesium was estimated using the ERICA Tool. The median internal dose-rate was 7.6 μGy/day (ranging from 1.8 to 219 μGy/day) and the external dose-rate was 13.9 μGy/day (ranging from 6.7 to 35.1 μGy/day). We performed multiple regression analyses to estimate the dose-rate effects on haematological values in peripheral blood and bone marrow. The white blood cell and platelet counts showed an inverse correlation with the internal dose-rate in mature macaques. Furthermore, the myeloid cell, megakaryocyte, and haematopoietic cell counts were inversely correlated and the occupancy of adipose tissue was positively correlated with internal dose-rate in femoral bone marrow of mature macaques. These relationships suggest that persistent whole body exposure to low-dose-rate radiation affects haematopoiesis in Japanese macaques.

  44. ddY Mice Fed 10% Fat Diet Exhibit High p27KIP Expression and Delayed Hepatocyte DNA Synthesis During Liver Regeneration. Peer-reviewed

    Saito Y, Kuwahara Y, Yamamoto Y, Suzuki M, Fukumoto M, Yamamoto F

    Metabolic syndrome and related disorders　16　(6)　305-313　2018/08

    DOI： 10.1089/met.2017.0131 　

    ISSN： 1540-4196

  45. 南相馬市・浪江町野生ニホンザル・アライグマの放射性セシウムの臓器内放射能濃度 Peer-reviewed

    田巻廣明, 小荒井一真, 木野康志, 西山純平, 金子拓, 小野拓実, 岡壽崇, 漆原佑介, 高橋温, 鈴木敏彦, 清水良央, 千葉美麗, 藤嶋洋平, Valerie Goh, See Ting, 有吉健太郎, 鈴木正敏, 三浦富智, 関根勉, 篠田壽, 福本学

    KEK Proceedings of the 19th Workshop on Environmental Radioactivity　2018　237-242　2018/01

  46. The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident Peer-reviewed

    Asako J. Nakamura, Masatoshi Suzuki, Christophe E. Redon, Yoshikazu Kuwahara, Hideaki Yamashiro, Yasuyuki Abe, Shintaro Takahashi, Tomokazu Fukuda, Emiko Isogai, William M. Bonner, Manabu Fukumoto

    RADIATION RESEARCH　187　(5)　630-636　2017/05

    DOI： 10.1667/RR14630.1 　

    ISSN： 0033-7587

    eISSN： 1938-5404

  47. 福島県内野生ニホンザルにおける放射性セシウムの体内分布. Peer-reviewed

    漆原 佑介, 鈴木 敏彦, 清水 良央, 鈴木 正敏, 桑原 義和, 木野 康志, 関根 勉, 林 剛平, 篠田 壽, 山城 秀昭, 磯貝 恵美子, 青野 辰雄, 福本 学

    KEK Proceedings 2017-6.　208-211.　2017/03

  48. Analysis of the Effect of Chronic and Low-Dose Radiation Exposure on Spermatogenic Cells of Male Large Japanese Field Mice (Apodemus speciosus) after the Fukushima Daiichi Nuclear Power Plant Accident Peer-reviewed

    Sachio Takino, Hideaki Yamashiro, Yukou Sugano, Yohei Fujishima, Akifumi Nakata, Kosuke Kasai, Gohei Hayashi, Yusuke Urushihara, Masatoshi Suzuki, Hisashi Shinoda, Tomisato Miura, Manabu Fukumoto

    RADIATION RESEARCH　187　(2)　161-168　2017/02

    DOI： 10.1667/RR14234.1 　

    ISSN： 0033-7587

    eISSN： 1938-5404

  49. Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1 Peer-reviewed

    Motohiro Yamauchi, Atsushi Shibata, Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda

    SCIENTIFIC REPORTS　7　2017/02

    DOI： 10.1038/srep41812 　

    ISSN： 2045-2322

  50. The involvement of mitochondrial membrane potential in cross-resistance between radiation and docetaxel. Peer-reviewed

    Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Masatoshi Suzuki, Yusuke Urushihara, Motoi Fukumoto, Yohei Saito, Manabu Fukumoto

    Journal of Radiation Oncology • Biology • Physics　96　(3)　556-565　2016/11

    DOI： 10.1016/j.ijrobp.2016.07.002 　

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    Purpose To understand the molecular mechanisms underlying cancer cell radioresistance, clinically relevant radioresistant (CRR) cells that continue to proliferate during exposure to 2 Gy/day X-rays for more than 30 days were established. A modified high-density survival assay for anticancer drug screening revealed that CRR cells were resistant to an antimicrotubule agent, docetaxel (DTX). The involvement of reactive oxygen species (ROS) from mitochondria (mtROS) in the cross-resistance to X-rays and DTX was studied.<br /> Methods and Materials Sensitivity to anticancer agents was determined by a modified high-density cell survival or water-soluble tetrazolium salt assay. DTX-induced mtROS generation was determined by MitoSOX red staining. JC-1 staining was used to visualize mitochondrial membrane potential. DTX-induced DNA double-strand breaks were determined by γ-H2AX staining. To obtain mitochondrial DNA-lacking (ρ0) cells, the cells were cultured for 3 to 4 weeks in medium containing ethidium bromide.<br /> Results Treatment with DTX increased mtROS in parental cells but not in CRR cells. DTX induced DNA double-strand breaks in parental cells. The mitochondrial membrane potential of CRR cells was lower in CRR cells than in parental cells. Depletion of mtDNA induced DTX resistance in parental cells. Treatment with dimethyl sulfoxide also induced DTX resistance in parental cells.<br /> Conclusions The mitochondrial dysfunction observed in CRR cells contributes to X-ray and DTX cross-resistance. The activation of oxidative phosphorylation in CRR cells may represent an effective approach to overcome radioresistant cancers. In general, the overexpression of β-tubulin or multidrug efflux pumps is thought to be involved in DTX resistance. In the present study, we discovered another DTX resistant mechanism by investigating CRR cells.

  51. 野生ニホンザルにおける福島原発事故由来放射性物質の影響評価. Peer-reviewed

    漆原 佑介, 鈴木 敏彦, 清水 良央, 藤田 詩織, 桑原 義和, 鈴木 正敏, 林 剛平, 安彦 亮, 鷲尾 亮太, 山城 秀昭, 阿部 靖之, 木野 康志, 関根 勉, 篠田 壽, 磯貝 恵美子, 青野 辰雄, 福本 学

    無菌生物.　46　(1)　19-21　2016/10

    ISSN： 0910-0903

    More details Close

    東京電力福島第一原子力発電所事故により福島県内では多くの野生動物が被災した。我々は福島県内で被災した野生ニホンザルに着目し、2013年より現在までに300頭以上から様々な臓器、筋肉などのサンプリングを行っている。採取した18の主要臓器と抹消血の放射性セシウム濃度を測定した結果、体内における放射性セシウム濃度は骨格筋が最も高く、甲状腺が最も低いことが明らかとなった。筋肉中放射性セシウム濃度と抹消血球像との間に明確な相関はみられなかったが、成獣の骨髄中顆粒球系細胞は筋肉中放射性セシウム濃度と負の相関を示し、脂肪細胞割合は筋肉中放射性セシウム濃度と正の相関を示した。これらの結果は、低線量慢性被ばくによる造血機能の低下を示唆するが、骨髄細胞の解析結果が放射線による影響であるかを結論付けるためには今後も解析を継続して行う必要がある

  52. Analysis of Plasma Protein Concentrations and Enzyme Activities in Cattle within the Ex-Evacuation Zone of the Fukushima Daiichi Nuclear Plant Accident Peer-reviewed

    Yusuke Urushihara, Koh Kawasumi, Satoru Endo, Kenichi Tanaka, Yasuko Hirakawa, Gohei Hayashi, Tsutomu Sekine, Yasushi Kino, Yoshikazu Kuwahara, Masatoshi Suzuki, Motoi Fukumoto, Hideaki Yamashiro, Yasuyuki Abe, Tomokazu Fukuda, Hisashi Shinoda, Emiko Isogai, Toshiro Arai, Manabu Fukumoto

    PLOS ONE　11　(5)　2016/05

    DOI： 10.1371/journal.pone.0155069 　

    ISSN： 1932-6203

  53. Correction: Analysis of Plasma Protein Concentrations and Enzyme Activities in Cattle within the Ex-Evacuation Zone of the Fukushima Daiichi Nuclear Plant Accident. International-journal Peer-reviewed

    Urushihara Y, Kawasumi K, Endo S, Tanaka K, Hirakawa Y, Hayashi G, Sekine T, Kino Y, Kuwahara Y, Suzuki M, Fukumoto M, Yamashiro H, Abe Y, Fukuda T, Shinoda H, Isogai E, Arai T, Fukumoto M

    PloS one　11　(8)　e0159282　2016

    DOI： 10.1371/journal.pone.0159282 　

    More details Close

    [This corrects the article DOI: 10.1371/journal.pone.0155069.].

  54. 被災家畜における生殖器官・機能影響の評価.

    山城 秀昭, 瀧野 祥生, 菅野 有晃, 漆原 佑介, 鈴木 正敏, 桑原 義和, 阿部 靖之, 小林 仁, 福田 智一, 木野 康志, 篠田 壽, 磯貝 恵美子, 福本 学

    京都大学原子炉実験所報告書 (KURレポート).　209.　78-81　2016/01

  55. 肉用牛の血液、及び筋肉における放射性セシウムの生物学的半減期.

    鈴木 正敏, 鈴木 秀彦, 石黒 裕敏, 木野 康志, 漆原 佑介, 齊藤 陽介, 渡邉 智, 小堤 知行, 曽地 雄一郎, 西 清志, 安彦 亮, 鷲尾 亮太, 桑原 義和, 沼辺 孝, 関根 勉, 福本 学

    京都大学原子炉実験所報告書 (KURレポート).　209.　(4)　86-91　2016/01

    ISSN： 2189-7107

  56. 被災ウシの血漿生化学検査による被ばく影響評価.

    漆原 佑介, 川角 浩, 平川 泰子, 遠藤 暁, 関根 勉, 木野 康志, 林 剛平, 桑原 義和, 鈴木 正敏, 福本 基, 山城 秀昭, 阿部 靖之, 福田 智一, 小林 仁, 磯貝 恵美子, 篠田 壽, 新井 敏郎, 福本 学

    京都大学原子炉実験所報告書 (KURレポート).　209　82-85　2016/01

  57. A comprehensive dose evaluation project concerning animals affected by the Fukushima Daiichi Nuclear Power Plant accident: its set-up and progress Peer-reviewed

    Shintaro Takahashi, Kazuya Inoue, Masatoshi Suzuki, Yusuke Urushihara, Yoshikazu Kuwahara, Gohei Hayashi, Soichiro Shiga, Motoi Fukumoto, Yasushi Kino, Tsutomu Sekine, Yasuyuki Abe, Tomokazu Fukuda, Emiko Isogai, Hideaki Yamashiro, Manabu Fukumoto

    JOURNAL OF RADIATION RESEARCH　56　I36-I41　2015/12

    DOI： 10.1093/jrr/rrv069 　

    ISSN： 0449-3060

    eISSN： 1349-9157

  58. Electron probe X-ray microanalysis of boar and inobuta testes after the Fukushima accident Peer-reviewed

    Hideaki Yamashiro, Yasuyuki Abe, Gohei Hayashi, Yusuke Urushihara, Yoshikazu Kuwahara, Masatoshi Suzuki, Jin Kobayashi, Yasuyuki Kino, Tomokazu Fukuda, Bin Tong, Sachio Takino, Yukou Sugano, Satoshi Sugimura, Takahisa Yamada, Emiko Isogai, Manabu Fukumoto

    JOURNAL OF RADIATION RESEARCH　56　I42-I47　2015/12

    DOI： 10.1093/jrr/rrv070 　

    ISSN： 0449-3060

    eISSN： 1349-9157

  59. Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance Peer-reviewed

    Motoi Fukumoto, Tatsuya Amanuma, Yoshikazu Kuwahara, Tsutomu Shimura, Masatoshi Suzuki, Shiro Mori, Hiroyuki Kumamoto, Yohei Saito, Yasuhito Ohkubo, Zhenfeng Duan, Kenji Sano, Tomohiro Oguchi, Kazuyuki Kainuma, Shinichi Usami, Kengo Kinoshita, Inchul Lee, Manabu Fukumoto

    CANCER SCIENCE　105　(10)　1351-1359　2014/10

    DOI： 10.1111/cas.12489 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  60. ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence Peer-reviewed

    Xiuquan Luo, Masatoshi Suzuki, Shanaz A. Ghandhi, Sally A. Amundson, David A. Boothman

    PLOS ONE　9　(6)　e99983　2014/06

    DOI： 10.1371/journal.pone.0099983 　

    ISSN： 1932-6203

  61. Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident Peer-reviewed

    Hideaki Yamashiro, Yasuyuki Abe, Tomokazu Fukuda, Yasushi Kino, Isao Kawaguchi, Yoshikazu Kuwahara, Motoi Fukumoto, Shintaro Takahashi, Masatoshi Suzuki, Jin Kobayashi, Emi Uematsu, Bin Tong, Takahisa Yamada, Satoshi Yoshida, Eimei Sato, Hisashi Shinoda, Tsutomu Sekine, Emiko Isogai, Manabu Fukumoto

    SCIENTIFIC REPORTS　3　2013/10

    DOI： 10.1038/srep02850 　

    ISSN： 2045-2322

  62. Live-Cell Imaging Visualizes Frequent Mitotic Skipping During Senescence-Like Growth Arrest in Mammary Carcinoma Cells Exposed to Ionizing Radiation Peer-reviewed

    Masatoshi Suzuki, Motohiro Yamauchi, Yasuyoshi Oka, Keiji Suzuki, Shunichi Yamashita

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　83　(2)　E241-E250　2012/06

    DOI： 10.1016/j.ijrobp.2011.12.003 　

    ISSN： 0360-3016

  63. 警戒区域で何が起こっているか – 牛における放射性物質の動態 Invited

    福本学, 磯貝恵美子, 福田智一, 木野康志, 関根勉, 篠田壽, 千葉美麗, 鈴木敏彦, 清水央, 高橋温, 西村真, 桑原義和, 志村勉, 鈴木正敏, 井上和也, 高橋慎太郎, 福本基, 阿部靖之, 山城秀昭, 小林仁, 森本素子, 三枝新, 小幡裕一

    家畜衛生学雑誌　38　105-106　2012

  64. Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts Peer-reviewed

    Masatoshi Suzuki, Keiji Suzuki, Seiji Kodama, Shunichi Yamashita, Masami Watanabe

    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY　2012

    DOI： 10.1155/2012/310534 　

    ISSN： 1942-0900

  65. Mode of ATM-dependent suppression of chromosome translocation Peer-reviewed

    Motohiro Yamauchi, Keiji Suzuki, Yasuyoshi Oka, Masatoshi Suzuki, Hisayoshi Kondo, Shunichi Yamashita

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　416　(1-2)　111-118　2011/12

    DOI： 10.1016/j.bbrc.2011.11.006 　

    ISSN： 0006-291X

  66. Persistence and Dynamics of DNA Damage Signal Amplification Determined by Microcolony Formation and Live-cell Imaging Peer-reviewed

    Yasuyoshi Oka, Motohiro Yamauchi, Masatoshi Suzuki, Shunichi Yamashita, Keiji Suzuki

    JOURNAL OF RADIATION RESEARCH　52　(6)　766-774　2011/11

    DOI： 10.1269/jrr.10164 　

    ISSN： 0449-3060

  67. Dedifferentiation of Human Primary Thyrocytes into Multilineage Progenitor Cells without Gene Introduction Peer-reviewed

    Keiji Suzuki, Norisato Mitsutake, Vladimir Saenko, Masatoshi Suzuki, Michiko Matsuse, Akira Ohtsuru, Atsushi Kumagai, Tatsuya Uga, Hiroshi Yano, Yuji Nagayama, Shunichi Yamashita

    PLOS ONE　6　(4)　e19354　2011/04

    DOI： 10.1371/journal.pone.0019354 　

    ISSN： 1932-6203

  68. Creating localized DNA double-strand breaks with microirradiation Peer-reviewed

    Keiji Suzuki, Motohiro Yamauchi, Yasuyoshi Oka, Masatoshi Suzuki, Shunichi Yamashita

    NATURE PROTOCOLS　6　(2)　134-139　2011/02

    DOI： 10.1038/nprot.2010.183 　

    ISSN： 1754-2189

  69. A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks Peer-reviewed

    Keiji Suzuki, Motohiro Yamauchi, Yasuyoshi Oka, Masatoshi Suzuki, Shunichi Yamashita

    NUCLEIC ACIDS RESEARCH　38　(12)　e129　2010/07

    DOI： 10.1093/nar/gkq226 　

    ISSN： 0305-1048

  70. Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases Peer-reviewed

    Keiji Suzuki, Maiko Takahashi, Yasuyoshi Oka, Motohiro Yamauchi, Masatoshi Suzuki, Shunichi Yamashita

    Genome Integrity　1　(1)　4　2010/05/26

    DOI： 10.1186/2041-9414-1-4 　

    ISSN： 2041-9414

  71. Acceleration of neural stem cell differentiation into astrocyte by X-irradiation Peer-reviewed

    Ayumi Ozeki, Masatoshi Suzuki, Hiroki Ozawa, Keiji Suzuki, Shunichi Yamashita

    NEUROSCIENCE RESEARCH　68　E131-E131　2010

    DOI： 10.1016/j.neures.2010.07.2150 　

    ISSN： 0168-0102

  72. A Possible Role of Stress-Induced Premature Senescence, SIPS, as a Producer of the Stress-Resistant Microenvironment Peer-reviewed

    Masatoshi Suzuki, Keiji Suzuki, Shunichi Yamashita

    Acta Medica Nagasakiensia　53　2009

    DOI： 10.11343/amn.53.S51 　

    ISSN： 0001-6055

  73. Stress-induced premature senescence (SIPS) - Influence of SIPS on radiotherapy Invited Peer-reviewed

    Masatoshi Suzuki, David A. Boothman

    JOURNAL OF RADIATION RESEARCH　49　(2)　105-112　2008/03

    DOI： 10.1269/jrr.07081 　

    ISSN： 0449-3060

  74. Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation Peer-reviewed

    M Suzuki, K Suzuki, S Kodama, M Watanabe

    RADIATION RESEARCH　165　(3)　269-276　2006/03

    DOI： 10.1667/RR3508.1 　

    ISSN： 0033-7587

  75. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest Peer-reviewed

    M Suzuki, K Suzuki, S Kodama, M Watanabe

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　340　(1)　145-150　2006/02

    DOI： 10.1016/j.bbrc.2005.11.167 　

    ISSN： 0006-291X

  76. Delayed induction of telomere instability in normal human fibroblast cells by ionizing radiation Peer-reviewed

    M Ojima, H Hamano, M Suzuki, K Suzuki, S Kodama, M Watanabe

    JOURNAL OF RADIATION RESEARCH　45　(1)　105-110　2004/03

    DOI： 10.1269/jrr.45.105 　

    ISSN： 0449-3060

  77. Possible role of ATM-dependent pathway in phosphorylation of p53 in senescent normal human diploid cells Peer-reviewed

    M Suzuki, K Suzuki, S Kodama, M Watanabe

    RADIATION AND HOMEOSTASIS, PROCEEDINGS　1236　371-373　2002

    ISSN： 0531-5131

  78. EFFECT OF MULTIPLE RADIATION WITH LOW-DOSES OF GAMMA-RAYS ON GROWTH ABILITY OF HUMAN EMBRYO CELLS-INVITRO Peer-reviewed

    M WATANABE, M SUZUKI, K SUZUKI, K NAKANO

    LOW DOSE IRRADIATION AND BIOLOGICAL DEFENSE MECHANISMS　1013　303-306　1992

    ISSN： 0531-5131

Show all ︎Show first 5

Misc. 35

  1. Cellular effects induced by radioactive particles generated by the accident of Fukushima Daiichi nuclear power plant

    和泉哉汰, 鈴木正敏, 遠藤暁, 佐藤拓, 稲葉洋平, 福本学, 千田浩一, 和泉哉汰, 鈴木正敏, 佐藤拓, 稲葉洋平, 福本学, 千田浩一

    日本診療放射線技師会誌　71　(10)　2024

    ISSN： 2187-2538

  2. Relationship between time-series changes of iodine-129 and cesium-137 in Japanese macaques captured in Fukushima Prefecture and its depth distribution in soil

    長岡壮太, 福本学, 鈴木正敏, 木野康志, 岡部宣章, 大野剛, 深海雄介

    日本地球化学会年会要旨集(Web)　70th　2023

  3. The study of oxidative stress status in the organs of wild Japanese macaque affected by the accident of Fukushima Daiichi nuclear power plant

    鈴木正敏, 鈴木正敏, 石川諒椰, 岡壽崇, 山下琢磨, 木野康志, 遠藤暁, 中島裕夫, 佐藤拓, 礒部理央, 千田浩一, 千田浩一, 福本学, 福本学

    アイソトープ・放射線研究発表会(Web)　60th　2023

    ISSN： 2436-4487

  4. 低線量・低線量率放射線の長期被ばくによる肝臓の酸化ストレス状態の変動

    石川 諒椰, 鈴木 正敏, 木野 康志, 遠藤 暁, 稲葉 洋平, 福本 学, 千田 浩一

    日本放射線技術学会雑誌　78　(9)　1104-1104　2022/09

    Publisher: (公社)日本放射線技術学会

    ISSN： 0369-4305

    eISSN： 1881-4883

  5. 浪江町の野生アライグマの放射性セシウムによる被ばく線量評価

    小野拓実, 小荒井一真, 木野康志, 田巻廣明, 岡壽崇, 岡壽崇, 高橋温, 鈴木敏彦, 鈴木敏彦, 清水良央, 千葉美麗, 藤嶋洋平, TING Valerie Goh Swee, 有吉健太郎, 中田章史, 鈴木正敏, 山城秀昭, 福本学, 関根勉, 関根勉, 篠田壽, 三浦富智, 三浦富智

    アイソトープ・放射線研究発表会要旨集　56th　2019

  6. 放射線汚染地域に生息するアライグマにおける細胞遺伝学的解析

    藤嶋洋平, 有吉健太郎, 中田章史, GOH Valerie, 葛西宏介, 小荒井一真, 鈴木正敏, 山城秀昭, 木野康志, 岡壽崇, 篠田壽, 吉田光明, 三浦富智

    日本放射線影響学会大会抄録(Web)　61st　66 (WEB ONLY)-66　2018/11

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  7. 歯のESR測定によるヒトおよび動物の外部被ばく線量評価

    岡壽崇, 岡壽崇, 高橋温, 小荒井一真, 木野康志, 関根勉, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 漆原佑介, 鈴木正敏, 福本学, 篠田壽

    日本分析化学会年会講演要旨集　67th　133-133　2018/08/29

    Publisher: (公社)日本分析化学会

  8. Measurements of Cs‐137 activity concentration in individual organs of wild raccoons in Namie town.

    小野拓実, 小荒井一真, 木野康志, 田巻廣明, 岡壽崇, 岡壽崇, 高橋温, 鈴木敏彦, 鈴木敏彦, 清水良央, 千葉美麗, 藤嶋洋平, TING Valerie Goh See, 有吉健太郎, 中田章史, 鈴木正敏, 山城秀昭, 三浦富智, 三浦富智, 関根勉, 関根勉, 篠田壽

    日本放射化学会年会・放射化学討論会研究発表要旨集(Web)　2018-62nd　ROMBUNNO.P26 (WEB ONLY)　2018

  9. 福島第一原発事故被災サルの歯と骨中90Srの相関および骨髄線量の推定

    小荒井 一真, 木野 康志, 西山 純平, 金子 拓, 高橋 温, 鈴木 敏彦, 清水 良央, 千葉 美麗, 小坂 健, 佐々木 啓一, 漆原 佑介, 鈴木 正敏, 福田 智一, 磯貝 恵美子, 岡 壽崇, 関根 勉, 福本 学, 篠田 壽

    日本放射線影響学会大会講演要旨集　60回　109-109　2017/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  10. Electron spin resonance dosimetry by measuring CO2 radicals in monkey teeth and deciduous teeth of Japanese children

    岡壽崇, 岡壽崇, 高橋温, 小荒井一真, 木野康志, 関根勉, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 漆原佑介, 鈴木正敏, 篠田壽, 福本学

    日本放射化学会年会・放射化学討論会研究発表要旨集(Web)　2017-61st　61 (WEB ONLY)　2017/09/01

  11. 東京電力福島第一原子力発電所周辺地域に生息する野生ニホンザルの体内放射性セシウム濃度の経年変化

    漆原 佑介, 鈴木 正敏, 鈴木 敏彦, 清水 良央, 桑原 義和, 宇野 壮春, 篠田 壽, 福本 学, 青野 辰雄

    霊長類研究 Supplement　33　(A11)　2017

    DOI： 10.14907/primate.33.0_38_1 　

  12. 被災アカネズミにおける精巣のEPMA分析

    大平拓也, 伊藤洵, 藤嶋洋平, 山城秀昭, 中田章史, 鈴木正敏, 有吉健太郎, 葛西宏介, 篠田壽, 三浦富智, 福本学

    KURRI-EKR (Web)　(15)　54‐64 (WEB ONLY)　2016/12

    ISSN： 2189-7107

  13. 低線量放射線の健康影響に関する研究と福島被災動物研究

    福本学, 福本学, 鈴木正敏, 漆原佑介, 漆原佑介, 林剛平

    KURRI-EKR (Web)　(15)　1‐12 (WEB ONLY)　2016/12

    ISSN： 2189-7107

  14. 東京電力福島第一原子力発電所事故の被災動物線量評価

    林剛平, 漆原佑介, 漆原佑介, 鈴木正敏, 遠藤暁, 今中哲二, 福本学

    KURRI-EKR (Web)　(15)　195‐203 (WEB ONLY)　2016/12

    ISSN： 2189-7107

  15. 福島県内野生ニホンザルへの被ばく影響評価

    漆原佑介, 鈴木敏彦, 清水良央, 桑原義和, 鈴木正敏, 林剛平, 斉藤彰, 藤田志織, 山城秀昭, 木野康志, 関根勉, 篠田壽, 青野辰雄, 福本学

    KURRI-EKR (Web)　(15)　70‐76 (WEB ONLY)　2016/12

    ISSN： 2189-7107

  16. 生体測定による筋肉中放射性セシウムの体内動態推定の可能性

    鈴木正敏, 木野康志, 鈴木秀彦, 石黒裕敏, 漆原佑介, 渡邉智, 齊藤陽介, 小堤知行, 曽地雄一郎, 西清志, 桑原義和, 沼辺孝, 関根勉, 福本学, 福本学

    KURRI-EKR (Web)　(15)　190‐194 (WEB ONLY)　2016/12

    ISSN： 2189-7107

  17. 福島原発事故のその後、再生を目指して 被災雄牛の継世代影響解析

    山城 秀昭, 高橋 秀和, 藤 晋一, 漆原 佑介, 鈴木 正敏, 桑原 義和, 阿部 靖之, 杉村 智史, 福田 智一, 木野 康志, 篠田 壽, 磯貝 惠美子, 福本 学

    無菌生物　46　(1)　22-23　2016/09

    Publisher: 日本無菌生物ノートバイオロジー学会

    ISSN： 0910-0903

    eISSN： 2436-7362

  18. 電子線マイクロアナライザによる被災アカネズミ精巣の元素分析

    大平拓也, 伊藤洵, 藤嶋洋平, 菅原淳史, 山城秀昭, 中田章史, 鈴木正敏, 有吉健太郎, 葛西宏介, 篠田壽, 三浦富智, 福本学

    日本放射線影響学会大会抄録(Web)　59th　ROMBUNNO.O4‐2 (WEB ONLY)-7　2016

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  19. 福島県内野生ニホンザルにおける東京電力福島第一原子力発電所事故由来放射性セシウムの体内分布および造血機能への影響解析

    漆原佑介, 鈴木敏彦, 清水吉央, 桑原義和, 鈴木正敏, 林剛平, 齋藤彰, 藤田詩織, 山城秀昭, 木野康志, 関根勉, 篠田壽, 青野辰雄, 福本学

    日本放射線影響学会大会抄録(Web)　59th　ROMBUNNO.P093 (WEB ONLY)-34　2016

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  20. 汚染粗飼料の給与による肉用牛の血中,および筋肉中の放射性セシウム濃度の推移

    鈴木正敏, 鈴木秀彦, 石黒裕敏, 木野康志, 漆原佑介, 渡邉智, 齊藤陽介, 小堤知行, 曽地雄一郎, 西清志, 安彦亮, 鷲尾亮太, 桑原義和, 沼辺孝, 関根勉, 福本学

    日本放射化学会年会・放射化学討論会研究発表要旨集　2015-59th　2015

    ISSN： 1345-2762

  21. 福島県内野生ニホンザルにおける福島第一原子力発電所事故由来放射性セシウムの体内分布

    漆原佑介, 漆原佑介, 鈴木敏彦, 清水良央, 藤田詩織, 桑原義和, 鈴木正敏, 福本基, 林剛平, 安彦亮, 鷲尾亮太, 山城秀昭, 阿部靖之, 木野康志, 関根勉, 篠田壽, 福本学

    日本放射化学会年会・放射化学討論会研究発表要旨集　2015-59th　137　2015

    ISSN： 1345-2762

  22. 福島原発事故被災動物の線量評価事業と霊長類動物への影響解析

    漆原佑介, 木野康志, 関根勉, 鈴木敏彦, 清水良央, 篠田壽, 桑原義和, 鈴木正敏, 川角浩, 山城秀昭, 新井敏郎, 福本学

    日本内分泌かく乱化学物質学会研究発表会要旨集　17th　39-39　2014/12/09

    Publisher: 環境ホルモン学会(日本内分泌撹乱化学物質学会)

  23. 震災・原発事故による野生生物への影響 3年半後の中間評価 被災雄牛における生殖器官および継世代影響評価の試み

    山城 秀昭, 阿部 靖之, 林 剛平, 漆原 佑介, 桑原 義和, 鈴木 正敏, 大段 隆史, 高橋 秀和, 藤 晋一, 瀧野 祥生, 菅野 有晃, 木野 康志, 福田 智一, 小林 仁, 磯貝 恵美子, 福本 学

    環境ホルモン学会研究発表会要旨集　17回　38-38　2014/12

    Publisher: 環境ホルモン学会(日本内分泌撹乱化学物質学会)

  24. 福島原発事故被災牛の血漿生化学検査と病理解析による被ばく影響評価

    漆原佑介, 川角浩, 平川泰子, 木野康志, 関根勉, 桑原義和, 鈴木正敏, 井上和也, 高橋慎太郎, 山城秀昭, 阿部靖之, 磯貝恵美子, 篠田壽, 新井敏郎, 福本学

    日本放射線影響学会大会講演要旨集　57th　90　2014/09/17

    ISSN： 1347-8680

  25. 福島第一原発事故旧警戒区域内被災動物中放射能分布

    木野康志, 入澤歩, 小荒井一真, 鈴木正敏, 漆原佑介, 阿部靖之, 山城秀昭, 福田智一, 磯貝恵美子, 小林仁, 岡壽崇, 関根勉, 篠田壽, 福本学

    日本放射化学会年会・放射化学討論会研究発表要旨集　2014-58th　145　2014/09/11

    ISSN： 1345-2762

  26. 東京電力福島第一原子力発電所事故による被災動物から放射線生物影響を考える 福島第一原発事故被災動物とその環境中の放射能測定

    木野 康志, 小荒井 一真, 入澤 歩, 漆原 佑介, 林 剛平, 鈴木 正敏, 阿部 靖之, 山城 秀昭, 福田 智一, 磯貝 恵美子, 小林 仁, 岡 壽崇, 関根 勉, 篠田 壽, 福本 学

    日本放射線影響学会大会講演要旨集　57回　91-91　2014/09

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  27. 東京電力福島第一原子力発電所事故による被災動物から放射線生物影響を考える DNA濃縮技術を用いた被災ウシの経世代的エクソン領域解析

    山城 秀昭, 阿部 靖之, 桑原 義和, 漆原 佑介, 鈴木 正敏, トウ・ビン, 瀧野 祥生, 菅野 有晃, 岩島 玲奈, 大段 隆史, 藤 晋一, 木野 康志, 福田 智一, 磯貝 恵美子, 福本 学

    日本放射線影響学会大会講演要旨集　57回　91-91　2014/09

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  28. 被災動物の包括的線量評価事業に関する事業立ち上げおよびシステム化

    井上 和也, 高橋 慎太郎, 林 剛平, 漆原 佑介, 鈴木 正敏, 桑原 義和, 阿部 靖之, 山城 秀昭, 篠田 壽, 福田 智一, 磯貝 恵美子, 福本 学

    日本放射線影響学会大会講演要旨集　56回　104-104　2013/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  29. 福島第一原子力発電所警戒区域内の豚における体内の放射性物質分布

    漆原 佑介, 木野 康志, 小林 仁, 関根 勉, 森本 素子, 阿部 靖之, 山城 秀昭, 桑原 義和, 鈴木 正敏, 福本 基, 井上 和也, 高橋 慎太郎, 福田 智一, 磯貝 恵美子, 福本 学

    日本放射線影響学会大会講演要旨集　56回　127-127　2013/10

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  30. p53-p21経路に依存した放射線誘発分裂期スキッピングの誘導

    鈴木正敏, 鈴木正敏, 鈴木啓司, 桑原義和, 山下俊一, 福本学

    日本病理学会会誌　102　(1)　2013

    ISSN： 0300-9181

  31. 低線量放射線被ばくによるDNA損傷の誘導と排除

    鈴木 正敏, 鈴木 啓司, 山下 俊一

    長崎醫學會雜誌 : Nagasaki Igakkai zasshi　87　239-242　2012/09/25

    Publisher: 長崎大学

    ISSN： 0369-3228

    More details Close

    放射線被ばくによる健康影響は,放射線により誘発されるDNA障害がその原因となって起こる.一方で,細胞には,こうしたDNA障害を修復する能力が普段から備わっており,生成されたDNA損傷を随時修復して排除している.しかしながら,被ばく線量に直線的に依存してDNA障害の数が増加すると,修復の能力を超えたり,あるいは誤った修復をする可能性が出てくる.最近,特に,100mGy(Sv)程度の低線量放射線被ばくによる健康影響について議論される機会が増えているが,疫学調査ではその技術的限界から,科学的に明確な結論を得ることが困難で,このことが,東京電力福島第一原発事故後の放射線に対する人々の不安にもつながっている.そこで,100mGyを下回るような低線量被ばくによるDNA障害の誘発と修復について,科学的に証明された事実を取得することを目的に本研究を計画した.

  32. Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation

    Ayumi Ozeki, Keiji Suzuki, Masatoshi Suzuki, Hiroki Ozawa, Shunichi Yamashita

    NeuroReport　23　(5)　290-293　2012/03/28

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/WNR.0b013e3283509a79 　

    ISSN： 0959-4965

  33. X-rays-induced phosphorylation of H2AX in mitotic cells :

    SUZUKI Masatoshi, SUZUKI Keiji, KODAMA Seiji, WATANABE Masami

    Journal of radiation research　43　(4)　444-444　2002

    Publisher: the Japan Radiation Research Society

    ISSN： 0449-3060

  34. Phosphorylation of p53 caused by radiation and telomere-shortening :

    SUZUKI Masatoshi, SUZUKI Keiji, KODAMA Seiji, WATANABE Masami

    Journal of radiation research　41　(4)　399-399　2000

    Publisher: the Japan Radiation Research Society

    ISSN： 0449-3060

  35. Analysis of Radioactive Elements in Testes of Large Japanese Field Mice Using an Electron Probe Micro-Analyser after the Fukushima Accident Invited Peer-reviewed

    Takuya Ohdaira, Kanna Meguro, Kazuki Komatsu, Rina Syoji, Yohei Fujishima, Valerie Swee, Ting Goh, Kosuke Kasai, Kentaro Ariyoshi, Akifumi Nakata, Yusuke Urushihara, Kazuma Koarai, Yasushi Kino, Tsutomu Sekine, Masatoshi Suzuki, Atsushi Takahasi, Yoshinaka Shimizu, Hisashi Shinoda, Mitsuaki A. Yoshida, Manabu Fukumoto, Hideaki Yamashiro, Tomisato Miura

    Ionizing and Non-ionizing Radiation

    DOI： 10.5772/intechopen.84634 　

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Presentations 30

  1. 福島第一原発事故に関する放射線生命科学研究

    鈴木正敏

    放射線発がん～現在・過去・未来～研究会　2026/03/30

  2. 原子力災害における環境防護の具体化にむけた取り組みについて

    鈴木正敏, 李嘉欣, 佐藤拓, 遠藤暁, 福本学, 千田浩一, 操上広志, 林誠二

    東日本大震災・原子力災害 第４回 学術研究集会　2026/03/19

  3. ESR線量測定法の低線量域適用のためのニホンザル歯試料プロトコルの改良

    林哲平, 山下琢磨, 光安優典, 小野健太, 岩見聡音, 木野康志, 関根勉, 岡壽崇, 高橋温, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 佐藤拓, 鈴木正敏, 福本学, 篠田壽

    第27回環境放射能研究会　2026/03/12

  4. 福島県浜通りで捕獲されたニホンザル臓器中の放射性核種およびsブロック元素濃度の測定

    長原辰弥, 林哲平, 加藤太朗, 木野康志, 山下琢磨, 鈴木正敏, 福本学

    第27回環境放射能研究会　2026/03/12

  5. 遺伝子発現変化から考察する不溶性セシウム粒子の性状と生物応答の関連性

    鈴木正敏, 遠藤暁, 二宮和彦, 千田浩一, 福本学

    第27回環境放射能研究会　2026/03/13

  6. 航空機モニタリングデータを取り入れた野生ニホンザルの外部被ばく線量評価

    佐藤拓, Jiaxin Li, 和泉哉汰, 本宮響太郎, 山下琢磨, 木野康志, 高橋温, 篠田壽, 遠藤暁, 福本学, 鈴木正敏, 千田浩一

    第27回環境放射能研究会　2026/03/12

  7. 環境レベルに近づけた低濃度トリチウム水の持続曝露による細胞影響解析

    和泉哉汰, 佐藤拓, Jiaxin Li, 本宮響太郎, 山下琢磨, 木野康志, 福本学, 鈴木正敏, 千田浩一

    第27回「環境放射能」研究会　2026/03/11

  8. 福島第一原発事故被災動物研究と放射線安全管理研究の接点 Invited

    鈴木正敏

    第3回短寿命 RI 利用研究シンポジウム　2025/11/28

  9. 歯のエナメル質を用いた ESR 線量測定法の低線量領域での実用に向けた線量応答曲線の個体間比較

    林哲平, 山下琢磨, 光安優典, 小野健太, 岩見聡音, 岡壽崇, 高橋温, 木野康志, 関根勉, 清水良央, 千葉美麗, 鈴木敏彦, 小坂健, 佐々木啓一, 佐藤拓, 鈴木正敏, 福本学, 篠田壽

    ESR応用計測研究会 ルミネッセンス年代測定研究会 フィッション・トラック研究会 2025年度合同研究会　2025/11/28

  10. Altered plasma SOD activity in wild Japanese Macaques affected by the Fukushima Dai-ichi nuclear power plant accident

    Jiaxin Li, Taku Sato, Kanata Izumi, Kyotaro Motomiya, Koichi Chida, Manabu Fukumoto, Masatoshi Suzuki, Yuji Owada, Tatsuo Aono

    第10回 福島原発事故による周辺生物への影響に関する勉強会　2025/11/08

  11. 不溶性セシウム粒子による遺伝子発現への影響

    鈴木正敏, 遠藤暁, 二宮和彦, 千田浩一, 福本学

    第10回福島原発事故による周辺生物への影響に関する勉強会　2025/11/08

  12. 航空機モニタリングデータを用いた福島第一原発事故被災野生ニホンザルの外部被ばく評価と体内酸化状態の解析

    佐藤拓, 遠藤暁, Jiaxin Li, 和泉哉汰, 本宮響太郎, 山下琢磨, 木野康志, 鈴木正敏, 福本学, 千田浩一

    第10回福島原発事故による周辺生物への影響に関する勉強会　2025/11/08

  13. 低濃度トリチウム水の持続暴露とDNA二重鎖切断誘発の検討

    和泉哉汰, 佐藤拓, 本宮響太郎, Jiaxin Li, 山下琢磨, 木野康志, 福本学, 鈴木正敏, 千田浩一

    第10回福島原発事故による周辺生物への影響に関する勉強会　2025/11/08

  14. Age-dependent internal exposure dose and carcinogenic effects of intratracheal instillation of insoluble radioactive particles in lung tumor-highly susceptible A/J mice

    Yuataka Yamada, Takamitsu Morioka, Satoru Endo, Kazuhiko Ninomiya, Kentaro Manabe, Masatoshi Suzuki

    The 68th Annual Meeting of the Japanese Radiation Research Society / The 6th Asian Congress of Radiation Research　2025/10/24

  15. Cellular effects induced by insoluble radioactive cesium-bearing microparticles derived from the Fukushima Daiichi nuclear power plant accident

    Masatoshi Suzuki, Satoru Endo, Kazuhiko Ninomiya, Kentaro Manabe, Yutaka Yamada, Koichi Chida, Manabu Fukumoto

    The 68th Annual Meeting of the Japanese Radiation Research Society / The 6th Asian Congress of Radiation Research　2025/10/25

  16. Optimization of the methods for assessing the effects of long-term low dose-rate radiation on animals inhabiting the affected area of nuclear disasters

    Taku Sato, Jiaxin Li, Ryoya Ishikawa, Kanata Izumi, Kyotaro Motomiya, Satoru Endo, Takuma Yamashita, Yasushi Kino, Manabu Fukumoto, Masatoshi Suzuki, Koichi Chida

    The 68th Annual Meeting of the Japanese Radiation Research Society / The 6th Asian Congress of Radiation Research　2025/10/25

  17. A study to improve external dose assessment for Japanese macaques affected by the Fukushima Daiichi nuclear power plant accident

    Jiaxin Li, Taku Sato, Kanata Izumi, Kyotaro Motomiya, Satoru Endo, Koichi Chida, Manabu Fukumoto,Masatoshi Suzuki, Owada Yuji, Tatsuo Aono

    The 68th Annual Meeting of the Japanese Radiation Research Society and the 6th Asian Congress of Radiation Research　2025/10/25

  18. The pathway that ionizing radiation induces tetraploid cells in G1 phase.

    Kyotaro Motomiya, Kanata Izumi, Taku Sato, Jiaxin Li, Manabu Fukumoto, Masatoshi Suzuki, Koichi Chida

    The 68th Annual Meeting of the Japanese Radiation Research Society / The 6th Asian Congress of Radiation Research（JRRS2025/ACRR2025）合同大会　2025/10/25

  19. Dynamics of co-localized foci of phosphorylated H2AX and 53BP1 induced by ionizing radiation

    Kanata Izumi, Taku Sato, Kyotaro Motomiya, Jiaxin Li, Manabu Fukumoto, Megumi Sasatani, Masatoshi Suzuki, Koichi Chida

    The 68th Annual Meeting of the Japanese Radiation Research Society / The 6th Asian Congress of Radiation Research　2025/10/25

  20. ATM機能抑制と放射線被ばく後の正常細胞の運命

    本宮響太郎, 和泉哉汰, 佐藤拓, Jiaxin Li, 福本学, 鈴木正敏, 千田浩一

    第53回日本放射線技術学会秋季学術大会　2025/10/18

  21. トリチウムの生物影響 Invited

    鈴木正敏

    第88回放射線安全フォーラム　2025/10/18

  22. 放射線被ばく後のDNA二重鎖切断マーカーの性状変化

    和泉哉汰, 佐藤拓, 本宮響太郎, Jiaxin Li, 稲葉洋平, 福本学, 鈴木正敏, 千田浩一

    第53回日本放射線技術学会秋季学術大会　2025/10/18

  23. GM管式小型サーベイメータの検出感度差の複数台比較

    本宮響太郎, 佐々木理桜, 山本啓介, 阿部喜弘, 越智隆浩, 稲葉洋平, 鈴木正敏, 千田浩一

    第15回東北放射線医療技術大会　2025/10/12

  24. Dose estimation of wild animals captured in the contaminated area of Fukushima Prefecture

    Toshitaka Oka, Hiroko Ishiniwa, Masatoshi Suzuki, Atsushi Takahashi, Taku Sato, Yusuke Mitsuyasu, Yasushi Kino, Kenichi Okutsu, Tsutomu Sekine, Takuma Yamashita, Yoshinaka Shimizu, Mirei Chiba, Toshihiko Suzuki, Ken Osaka, Keiichi Sasaki, Manabu Fukumoto, Hisashi Shinoda

    33rd Miller Conference on Radiation Chemistry　2025/10/06

  25. IAEA-coordinated research on external dosimetry for terrestrial wildlife

    Alexander Ulanowski, James Beasley, K. Beaugelin-Seiller, Shaofei Cao, Sandrine Frelon, Dmytri Holiaka, A. Hooker, Mathew Johansen, V. Kashparov, Maksim Kudzin, O. C. Lind, Yuichi Onda, N. Rathnaweera, Sedigheh Sina, Heny Suseno, Masatoshi Suzuki, Thiwanka, Lakmali Weerakkody

    8th International Symposium on the System of Radiological Protection　2025/10/08

  26. Modeling biokinetics of insoluble cesium-absorbed particles following intratracheal administration in mice

    Kentaro Manabe, Yutaka Yamada, Takamitsu Morioka, Kazuhiko Ninomiya, Satoru Endo, Masatoshi Suzuki

    7th Asia-Pacific Symposium on Radiochemistry　2025/09/15

  27. Cellular effects induced by radiocesium-bearing microparticles (CsMPs)

    Masatoshi Suzuki, Satoru Endo, Kazuhiko Ninomiya, Koichi Chida, Manabu Fukumoto

    7th Asia-Pacific Symposium on Radiochemistry　2025/09/14

  28. 福島第一原発事故に被災した野生ニホンザルの外部被ばく評価法の構築と血漿および肝臓の酸化ストレス状態解析

    佐藤拓, Jiaxin Li, 石川諒椰, 和泉哉汰, 本宮響太郎, 遠藤暁, 山下琢磨, 木野康志, 福本学, 鈴木正敏, 千田浩一

    第5回若⼿放射線影響研究会　2025/08/22

  29. 細胞系譜解析による放射線誘発老化様増殖停止とマイトティックカタストロフィの交点

    本宮響太郎, 和泉哉汰, 佐藤拓, Jiaxin Li, 福本学, 鈴木正敏, 千田浩一

    第5回若手放射線影響研究会　2025/08/22

  30. 放射線誘発DNA二重鎖切断フォーカスの質的解析

    和泉哉汰, 佐藤拓, 本宮響太郎, Jiaxin Li, 山下琢磨, 木野康志, 福本学, 笹谷めぐみ, 鈴木正敏, 千田浩一

    第5回若手放射線影響研究会　2025/08/22

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Research Projects 17

  1. 高精度計測技術に基づくトリチウムの環境・生物影響の理解とリスク評価法の確立

    赤田 尚史, 田中 将裕, 平尾 茂一, 鈴木 正敏, 笹谷 めぐみ, 田副 博文, 田中 和貴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(A)

    Institution: 弘前大学

    2025/04/01 - 2029/03/31

  2. 低線量・低線量率放射線長期被ばく影響に抗酸化能の抑制が関与するのか?

    鈴木 正敏, 千田 浩一, 遠藤 暁

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2024/04/01 - 2028/03/31

  3. Establishment and Improvement of External Dosimetry Using the Model of Wild Japanese Macaque and the Large Japanese Field Mice (Apodemus Speciosus) in Fukushima for the Evaluation of Long-Term Low Dose Exposure

    Masatoshi Suzuki, Manabu Fukumoto, Koichi Chida, Satoru Endo, Yasushi Kino, Tomisato Miura, Toshitaka Oka, Hideaki Yamashiro, Yohei Inaba

    Offer Organization: IAEA

    System: Coordinated Research Project

    Institution: IRIDeS, Tohoku University

    2022/12 - 2027/12

  4. 新規解析モデルを活用する正常水晶体細胞の低線量域放射線への応答とp53関与の解析

    千田 浩一, 山本 直樹, 鈴木 正敏

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2023/04/01 - 2027/03/31

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    水晶体の職業被ばくが生じるインターベンショナル・ラジオロジー（IVR）に従事する医療スタッフの水晶体被ばく線量に関するデータをある程度収集することができた。 野生ニホンザルから採取した水晶体中の酸化ストレス解析方法の改良に取り組んだ。本解析では試料中のマロンジアルデヒド（MDA）とチオバルビツール酸の付加体を形成させて波長480から700 nmまでの範囲を1nmずつ吸光度を測定して得られるスペクトルを解析した。535 nm付近でのみ示される吸収のピークとその他の波長範囲の水平なベースラインの2成分が得られるので、535nmのピーク高から検量線を用いてMDA濃度が定量できる。しかしながら、組織試料解析では、ベースライン部分に起伏が生じて平坦なベースラインが得られないため、535nmのピーク高を正確に取得できずにMDAを評価できない課題が生じた。試料調整前に血液を取り除くことで解析可能なスペクトルが得られるようになった。また、血液除去過程が不十分であるとMDA濃度の正確性に影響を及ぼすことも分かった。本年度は組織試料を用いてMDA濃度を解析するためのプロトコールを確立し、従来法では定量が困難であった個体試料の評価できるようになったこと、従来よりも誤差範囲を小さくできるために低線量率被ばくによるわずかな変化を評価できる解析手法を確立した。 p53が機能するヒト水晶体上皮細胞の樹立するために、白内障手術時に切除される前のう片に接着しているヒト水晶体上皮細胞の初代培養を行った。研究分担者が開発した不死化ベクターは、従来の不死化ベクターと異なり遺伝子の特異的な領域に不死化遺伝子を選択的に導入することが可能であるため、水晶体上皮細胞の特徴が保持された不死化ヒト水晶体上皮細胞株（iHLEC-NY1）を作製することに成功した。

  5. 低濃度放射性セシウムへの持続被ばくによる高感度ゲノム変異評価補助事業

    千田浩一、鈴木正敏

    Offer Organization: JKA

    System: 機械振興事業

    Institution: 東北大学災害科学国際研究所

    2025/04 - 2027/03

  6. Is the archive of animals affected by the Fukushima nuclear power plant accident Useful for radiation effects analysis?

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Institute of Physical and Chemical Research

    2023/04/01 - 2026/03/31

  7. 不溶性セシウム粒子の生物影響に関する理解深化を目指す分野横断共同研究

    鈴木正敏, 二宮和彦, 遠藤暁, 山田裕, 真辺健太郎

    Offer Organization: 環境省

    System: 放射線健康管理・健康不安対策事業（放射線の健康影響に係る研究調査事業）

    Institution: 東北大学災害科学国際研究所

    2023/04 - 2026/03

  8. 抗酸化能は放射線晩期障害のインディケーターとなるか

    盛武 敬, 孫 略, 鈴木 正敏

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 国立研究開発法人量子科学技術研究開発機構

    2021/07/09 - 2024/03/31

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    放射線晩発障害の発症リスクを被ばく後の早期に予測できれば、予防的介入(治療)も可能となり、晩発障害の発症を抑えることが可能となるが、晩発障害のほとんどの疾患は酸化ストレス(活性酸素種(ROS)の増加や抗酸化能の低下によって引き起こされる状態のこと)との関連が明らかになっている。本研究では、抗酸化能を指標とした晩発障害リスク予測の妥当性を明らかにすることを目的としている。初年度の研究実績については、 ①低線量低線量率照射装置を用いてマウスに慢性照射(33 μGy/min～12.5 mGy/hr; 1～60日間;総線量0.1~5 Gy)を行い、照射後からマウスが死亡するまで経時的に採血し、抗酸化能関連指標(血液抗酸化能(i-STrap法による測定)、グルタチオン量など)や酸化ストレスの原因となる慢性炎症関連サイトカイン(IL-6、TNF、IL-1β、MCP-1など)の測定を行うことを目標にしており、現在マウス飼育室と照射の準備を完了し、順次購入されたマウスに照射を行い飼育観察を続けている。 ②福島県で害獣として処分された野生ニホンザルから採血し、抗酸化能関連指標(血液抗酸化能、グルタチオン量など)や酸化ストレスの原因となる慢性炎症関連サイトカイン(IL-6、TNF、IL-1β、MCP-1など)の解析を行い、生息地や体内の放射線量からサルの被ばく線量を割り出し、各指標と被ばく線量、年齢、性別などの関係を明らかにすることを目標にしており、現在冬場に捕獲された野生ニホンザルからの血液のストックを行っている。

  9. 有機結合型トリチウムを用いた低濃度トリチウム影響解析

    鈴木 正敏

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

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    本研究は低濃度で持続的なトリチウム曝露による細胞影響を明らかにすることで、トリチウム影響に関して不足している科学的知見を集積するために実施した。特に内部被ばくの長期化と関連する有機結合型トリチウム(OBT)による影響について、トリチウム水による影響との比較を行なっている。本年度は特に、従来よりも低濃度トリチウム処理を行なった際の細胞内取り込みについて検討を行なった。 細胞内への取り込みについては、培地中にトリチウムを添加して24時間後以降から継日的に培地中と細胞中のトリチウムを液体シンチレーションカウンタで測定した。まず、従来よりも低い濃度(7.4 kBq/ml)のトリチウム水を処理したところ、トリチウム添加24時間後までに増加していた細胞内トリチウムは、その後、添加7日後までに著しい変化はみられなかった。OBTとしてトリチウムグルコースやトリチウムチミジンをトリチウム水と同じ濃度で処理したところ、それぞれ添加後2日目と6日目に細胞内トリチウム濃度が最大となった。トリチウム水や今回使用したOBTは添加量の9割以上が培地内に残っており、細胞内への取り込みはトリチウム水とトリチウムグルコースで1%以下、トリチウムチミジンで4 %程度であることがわかった。また、細胞核と細胞質の分画を抽出してそれぞれの分画中のトリチウムを測定すると、トリチウム水では細胞核と細胞質にほぼ同程度のトリチウムが分布していた一方で、OBTではその化学形態に依存して細胞内に局在していることが示された。従来のOBTを用いた細胞影響では処理濃度で細胞影響を比較することが多かったが、本年度得られた結果をもとに線量評価を行なうことで、トリチウム水とOBTによる生物影響を同一の指標を用いて評価するための基礎的知見として利用することが期待される。

  10. Radiopathological analysis of Japanese macaques affected by the Fukushima Daiichi Nuclear Power Plant accident

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Institute of Physical and Chemical Research

    2020/04/01 - 2023/03/31

  11. Integrated study between field work and bench work to investigate radiation effect affected by the accident of Fukushima Nuclear Power Plant

    Suzuki Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    We here investigated if low dose /low dose rate radiation exposure elicits delayed instability as high dose radiation exposure did. We established the immortalized cells from femoral muscle of wild Japanese Macaque living in ex-evacuation zone. Compared with the immortalized cells established from the muscle of control Japanese Macaque, delayed effects shown as induction of DNA double-strand breaks or global methylation did not appear even in the cells made from exposed Japanese Macaque. Based on the system we here established, investigation using tissue other than muscle is necessary to comprehensively discuss radiation effect among different organs.

  12. Is mitochondrial DNA with normal function necessary for cellular radioresistance?

    Fukumoto Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tokyo Medical University

    2016/04/01 - 2018/03/31

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    We analyzed the role of mitochondria (mt) on the phenotype expression of CRR cells that continue to proliferate under fractionated irradiation of 2 Gy/day x-rays. Reactive oxygen species (ROS) derived from mt was detected in the parent cells after acute irradiation with 10 Gy, but was not detected in CRR cells, and the mitDNA copy number and ATP amount were decreased. Using ethidium bromide, mtDNA deleted ρ0 cells could be established from parental ells but was impossible from CRR cells. Only one ρ0 cells could be established from HepG2-CRR to which maintenance irradiation paused. Expression of the antioxidant enzyme group in ρ0 cells showed no specific tendency compared to the parental cells but was rather sensitive to H202. It was suggested that the influx of H 2O2 is accelerated by the decrease in cell membrane potential of ρ0 cells.

  13. Analysis of biokinetics and effects of internally deposited radionuclides in animals by the Fukushima nuclear power plant accident

    Fukumoto Manabu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    2014/04/01 - 2018/03/31

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    We have constructed an archive system of organs affected by the Fukushima Daiichi Nuclear Power Plant accident and obtained the following results. Two years after the accident, almost only radioactive cesium was detected in all organs examined. Oxidative stress related molecules in cattle plasma were correlated with internal dose-rate. DNA double strand breaks in cattle lymphocytes were higher than non-affected controls. Large Japanese field mice were significantly exposed to both gamma- and beta-rays. The turnover of their spermatogenesis was accelerated. However, no abnormalities was detected in mature sperms including cattle. Bone marrow of wild Japanese macaques tended to be hypoplastic, but no abnormality was found in peripheral blood cells. Although no significant changes have been observed, internal dose rate in monkeys is still high. Therefore, it is necessary to continue detailed study to know biological effects of long-term exposure to low dose-rate radiation.

  14. Is the cancer stem cell hypothesis useful to conquer radioresistant cancers?

    Fukumoto Manabu, KUWAHARA YOSHIKAZU, SUZUKI MASATOSHI, URUSHIHARA YUUSUKE

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2014/04/01 - 2016/03/31

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    Recently, the cancer stem cell (CSC) is suggested to be resistant against therapy and recurrence. The fraction of CSCs was higher in clinically relevant radioresistant cells than in their parental cells. However, a long-term low dose fractionated radiation resulted in radioresistance of parental cells but did not increase CSCs fraction. We therefore conclude that the CSC phenotype is not involved in the acquisition of radioresistance of cancer cells.

  15. Analysis of TGF be-ta/EMT axis on the formation of clinically-relevant radioresistant phenotype

    SUZUKI MASATOSHI, FUKUMOTO Manabu, KUWAHARA Yoshikazu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    We investigated the inducible radioresistant mechanism that cancer cells are able to proliferate under 2 Gy/day of fractionated radiation exposure, so called clinically-relevant radioresistant phenotype (CRR). For CRR formation, we revealed that pre-exposure with less than 2 Gy/day of fractionated dose and stepwise dose-escalation was critically required prior to 2 Gy/day of fractionated exposure. Pre-exposure with lower fractionated dose brought radioresistant phenotype (acquired radioresistance, ARR) and dose-escalation gradually enhanced radioresisntace. We also found that the nature of cancer stem cell or epithelial-mesenchymal transition, which is generally known as the factors contributing acquired radioresistance, was not involved in CRR formation. We also found less DNA damage, especially DNA double strand breaks, in radioresistant cells and that suppression of DNA-damage response might be involved in the mechanism of ARR and/or CRR formation.

  16. The mechanism of amplification in DNA-damage signaling for enhancement of radiosensitivity

    SUZUKI Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    2011 - 2012

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    DNA double-strand breaks trigger activation of signal transduction pathways including induction of cell death. Recently, it is suggested that the amplification of DNA damage signaling could be related to the effective cell death induction. In this study, we revealed that the amplification of DNA-damage signaling was suppressed in tumor cell lines.We also demonstrated cell cycle phase-dependency in the amplification of DNA-damage signaling.

  17. Elucidation of pathway and molecular mechanism of radiation-induced non-apoptotic cell death mode in human solid carcinoma cell

    SUZUKI Masatoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Nagasaki University

    2009 - 2010

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    Live-cell imaging of mammary carcinoma cell line revealed prolonged cell cycle arrest as a predominant cell death mode induced by ionizing radiation. Regardless cell cycle phase that exposed to ionizing radiation, prolonged cell cycle arrest was induced in G1 phase. Particularly, direct cell cycle progression from G2 to G1 phase without mitosis was observed by G2-irradiation in presence of p53, suggesting that radiochemotherapy combined with taxane-treatment increases the treatment-sensitivity for p53-depleted carcinoma cells.

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Teaching Experience 7

  1. 放射線安全管理科学トレーニング　東北大学

  2. 放射線安全管理科学特論　東北大学

  3. 被ばく影響学概論　弘前大学

  4. 放射線技術学専攻学生実験　東北大学

  5. 巨大災害に対する健康と社会のレジリエンス　東北大学

  6. 福島の復興・再生　東北大学

  7. 災害から人の健康・ウェルビーイングを守る！　東北大学

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