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Kazuko Omodaka

Section

Tohoku University Hospital

Job title

Assistant Professor

Degree

researchmap

https://researchmap.jp/tohoku_oph

J-GLOBAL ID

201801014671437585

e-Rad No.

80569583

Research Areas 1

Life sciences / Ophthalmology /

Awards 8

第1回北澤克明記念学術研究助成 (北澤賞)

2021/03　日本緑内障学会
第25回 ROHTO AWARD

2019/10
日本眼科学会学術奨励賞

2018/04
須田記念緑内障治療研究症例基金

2017/02
宮城県眼科医会学術奨励賞

2015/01
東北医学会奨学賞B

2015/01
緑内障学会フェローシップグラント

2014/09
宮城県女医会研究助成

2014/07

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Papers 152

High-accuracy retinal age prediction via fundus-based multitask learning reveals the effect of systemic disease. International-journal

Takahiro Ninomiya, Akiko Hanyuda, Naoki Kiyota, Parmanand Sharma, Yukun Zhou, Siegfried K Wagner, Keita Suzuki, Takanari Nozaki, Takehiro Miya, Naoki Takahashi, Kazuko Omodaka, Noriko Himori, Yoichi Ichikawa, Pearse A Keane, Toru Nakazawa

Communications medicine　2026/04/08

DOI： 10.1038/s43856-026-01573-y 　

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BACKGROUND: Accurate estimation of the retinal age, defined as the age predicted from fundus photographs by a deep-learning model trained on chronological age, provides a non-invasive biomarker of biological ageing and disease risk. METHODS: In this study, we trained an ensemble multitask learning model that integrates fundus photographs with glycated haemoglobin using 50,595 quality-controlled fundus photographs from 27,214 disease-free adults and validated it on an independent set of 7288 additional images from disease-free adults. Model performance was evaluated using mean absolute error. Prediction uncertainty was quantified by calculating the standard deviation across ensemble predictions for each eye, and eyes were stratified based on this standard deviation. RESULTS: Here we show that the model achieves mean absolute errors of 2.78 years in internal validation and 3.39 years and 8.63 years in two external cohorts comprising 135 and 4992 eyes, respectively. Eyes with ensemble standard deviations below the median demonstrate improved age-prediction accuracy (mean absolute error: 2.46 years internally; 2.87 years in the primary external cohort). In a systemic disease cohort of 8467 individuals, the retinal age gap (predicted minus chronological age) is significantly higher in participants with diabetes, cardiac disease, or stroke after adjustment for age and sex, indicating older-appearing retinas and supporting the biological relevance of retinal age. CONCLUSIONS: Retinal age derived from a single fundus photograph provides a scalable and clinically deployed biomarker of biological ageing. This approach may enable opportunistic screening for cardiometabolic and other ageing-related diseases in other routine ocular imaging workflows.
The Relationship Between MRI-Measured Structure of the Visual Cortex and Visual Function in Patients With Glaucoma. International-journal

Akio Yamada, Yasuko Tatewaki, Kazuko Omodaka, Izumi Matsudaira, Yasuyuki Taki, Toru Nakazawa

Journal of glaucoma　34　(10)　735-743　2025/10/01

DOI： 10.1097/IJG.0000000000002614 　

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PRCIS: The area corresponding to the peripheral visual field in the primary visual cortex of the brain is associated with ophthalmologic parameters. PURPOSE: Reproducing the relationship of the visual field with the primary visual cortex is known as retinotopic mapping. The primary visual cortex is known to be atrophic in glaucoma patients. However, there are few reports on which areas most reflect glaucomatous changes. In this study, we used magnetic resonance imaging to evaluate the relationship between various ophthalmic parameters and overall and regional structural changes in the primary visual cortex to better understand changes in the brain associated with glaucoma. MATERIALS AND METHODS: Twelve healthy subjects [56.1±9.3 y old, male to female ratio 6:6, mean deviation (MD) 0.6±0.7 dB] and 23 patients with glaucoma (57.8±8.0 y old, male to female ratio 8:15, MD: -10.2±6.4 dB) were enrolled. We acquired 3D-T1-weighed images to measure the overall and regional gray matter density of the visual cortex based on a priori retinotopic projection. Optical coherence tomography and visual field testing were performed, and a weighted count of retinal ganglion cells (wRGC) was calculated from the ophthalmological tests. The Spearman rank correlation coefficient was used for evaluating the correlations between these structural parameters of the visual cortex and the ophthalmological parameters. RESULTS: The overall primary visual cortex was positively correlated with MD ( r =0.40, P =0.02) and wRGC ( r =0.41, P =0.02). Regarding retinotopic projection, the inner area in the visual cortex, which corresponds to the peripheral visual field, was positively correlated with MD and wRGC. CONCLUSION: The inner part of the primary visual cortex, which corresponds to the peripheral visual field, is closely correlated with ophthalmologic parameters commonly used for diagnosing and detecting the progression of glaucoma clinically. This suggests that evaluation of this area with MRI may be of clinical use in glaucoma assessment and monitoring.
Differentiation of acute-phase AQP4-IgG+ optic neuritis from CNS inflammatory diseases using optic nerve head blood flow analysis. International-journal

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Tatsuro Misu, Kimihiko Kaneko, Mizuki Otomo, Airi Takagi, Takahiro Oshima, Ryo Kimura, Kazuko Omodaka, Satoru Tsuda, Masashi Aoki, Toru Nakazawa

Scientific reports　15　(1)　33618-33618　2025/09/29

DOI： 10.1038/s41598-025-19110-7 　

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Early diagnosis of optic neuritis (ON) associated with aquaporin-4 immunoglobulin-G (AQP4-IgG), myelin oligodendrocyte glycoprotein immunoglobulin-G (MOG-IgG), or multiple sclerosis (MS) is challenging due to invasive and time-consuming tests. We investigated whether ophthalmologic assessments, including laser speckle flowgraphy (LSFG) and optical coherence tomography (OCT), are useful for distinguishing among these diseases at ON onset. This retrospective study included 10 AQP4-IgG+ON patients, 20 MOG-IgG+ON patients, 9 MS-ON patients, and 27 idiopathic ON (ION) patients at initial onset, and 66 propensity-score-matched control eyes. We measured mean blur rate (MBR), representing blood flow velocity, using LSFG and assessed optic nerve head (ONH) vessel-area MBR (ONH-MV), tissue-area MBR (ONH-MT), and peripapillary choroidal MBR. Circumpapillary retinal nerve fiber layer (cpRNFL) thickness was measured with OCT. We found that MOG-IgG+ON patients had a significantly thicker cpRNFL than AQP4-IgG+ON patients and controls (P < 0.05). AQP4-IgG+ON and MOG-IgG+ON patients had significantly lower ONH-MV than controls (P ≤ 0.001). AQP4-IgG+ON patients had significantly lower ONH-MT than MOG-IgG+ON, MS-ON, ION patients, or controls, and lower choroidal MBR than controls (P < 0.05). A receiver operating characteristic analysis combining cpRNFL thickness, ONH-MV, ONH-MT, and choroidal MBR achieved an area under the curve of 0.892 in differentiating AQP4-IgG+ON from other diseases (P < 0.001). LSFG and OCT could distinguish AQP4-IgG+ON from other diseases at onset non-invasively.
軽量なディープラーニングモデルを用いた正確で解釈可能な緑内障スクリーニング法(Accurate and Explainable Glaucoma Screening via Lightweight Deep Learning Models)

Sharma Parmanand, 高橋直樹, 二宮高洋, 佐藤正隆, 宮武博, 津田聡, 面高宗子, 檜森紀子, 中澤徹

日本緑内障学会抄録集　36回　140-140　2025/09
Publisher: 日本緑内障学会
Reduced plasma oxytocin levels in patients with open-angle glaucoma.

Yurina Yamada, Kota Sato, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Chiaki Yamaguchi, Kazuko Omodaka, Toru Nakazawa

Japanese journal of ophthalmology　2025/07/14

DOI： 10.1007/s10384-025-01248-6 　

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PURPOSE: We explored the role of oxytocin in glaucoma by measuring the blood levels of oxytocin in glaucoma patients, comparing them to normal control subjects, and examining its association with clinical parameters. STUDY DESIGN: Retrospective cross-sectional study. MATERIAL AND METHODS: After obtaining informed consent from 181 glaucoma patients and 44 age-matched control participants, we collected blood samples in ethylenediaminetetraacetic acid (EDTA) tubes and centrifuged them at 2000 g for 25 minutes at 4 °C. The resulting plasma was assayed for oxytocin concentration with an Enzyme Linked Immunosorbent Assay (ELISA) kit. We compared oxytocin concentrations in the control and glaucoma groups, and within the glaucoma group, we determined whether the oxytocin levels were correlated with mean deviation (MD) and sectoral total deviation (TD). Furthermore, in 33 patients who underwent at least five visual field tests over a two-year period following oxytocin measurements and received no surgical interventions during that time, we determined whether the oxytocin levels were correlated with MD slope and sectoral TD slopes. RESULTS: Oxytocin levels in glaucoma patients were significantly lower than in age- and sex-matched normal controls (723.34 ± 303.44 vs. 557.59 ± 296.04 pg/ml, p=0.002). In glaucoma patients, oxytocin levels were significantly correlated with MD and inferior TD after adjustment for age and sex (β=0.149, p=0.041; β=0.156, p=0.034, respectively). There was a weak negative correlation between oxytocin concentration and MD slope (β=-0.334, p=0.084) and a weak negative correlation with central TD slope (β=-0.405, p=0.039), adjusted for age, sex, and history of additional eye drops. CONCLUSION: Oxytocin concentrations in glaucoma patients were significantly lower than in normal subjects and associated with the severity and progression of visual field defects. Given the wide variety of the pharmacological actions of oxytocin, it may be involved in the pathogenesis of glaucoma. Our results suggest that plasma oxytocin measurements may open a new avenue for glaucoma care.
Evaluation of blood flow in arteritic anterior ischemic optic neuropathy using laser speckle flowgraphy: A case series

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Takahiro Oshima, Takayuki Takeshita, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

American Journal of Ophthalmology Case Reports　38　2025/06

DOI： 10.1016/j.ajoc.2025.102316 　

ISSN： 2451-9936
Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study. International-journal

Akiko Hanyuda, Yoshihiko Raita, Takahiro Ninomiya, Kazuki Hashimoto, Naoko Takada, Kota Sato, Jin Inoue, Seizo Koshiba, Gen Tamiya, Akira Narita, Masato Akiyama, Kazuko Omodaka, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Yasuko Yamamoto, Takazumi Taniguchi, Kazuno Negishi, Toru Nakazawa

Investigative ophthalmology & visual science　65　(13)　44-44　2024/11/04

DOI： 10.1167/iovs.65.13.44 　

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PURPOSE: The purpose of this study was to investigate biologically meaningful endotypes of open-angle glaucoma (OAG) by applying unsupervised machine learning to plasma metabolites. METHODS: This retrospective longitudinal cohort study enrolled consecutive patients aged ≥20 years with OAG at Tohoku University Hospital from January 2017 to January 2020. OAG was confirmed based on comprehensive ophthalmic examinations. Among the 523 patients with OAG with available clinical metabolomic data, 173 patients were longitudinally followed up for ≥2 years, with available data from ≥5 reliable visual field (VF) tests without glaucoma surgery. We collected fasting blood samples and clinical data at enrollment and nuclear magnetic resonance spectroscopy to profile 45 plasma metabolites in a targeted approach. After computing a distance matrix of preprocessed metabolites with Pearson distance, gap statistics determined the optimal number of OAG endotypes. Its risk factors, clinical presentations, metabolomic profiles, and progression rate of sector-based VF loss were compared across endotypes. RESULTS: Five distinct OAG endotypes were identified. The highest-risk endotype (endotype B) showed a significant faster progression of central VF loss (P = 0.007). Compared with patients with other endotypes, those with endotype B were more likely to have a high prevalence of dyslipidemia, cold extremities, oxidative stress, and low OAG genetic risk scores. Pathway analysis of metabolomic profiles implicated altered fatty acid and ketone body metabolism in this endotype, with 34 differentially enriched pathways (false discovery rate [FDR] < 0.05). CONCLUSIONS: Integrated metabolomic profiles identified five distinct etiologic endotypes of OAG, suggesting pathological mechanisms related with a high-risk group of central vision loss progression in the Japanese population.
Relationship between corneal hysteresis and the site of damage to peripapillary retinal nerve fibre layer thickness in open-angle glaucoma. International-journal

Yoko Takeda, Akiko Hanyuda, Naoki Takahashi, Kazuko Omodaka, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Yu Yokoyama, Noriko Himori, Airi Takagi, Toru Nakazawa

Scientific reports　14　(1)　26329-26329　2024/11/01

DOI： 10.1038/s41598-024-76187-2 　

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Corneal hysteresis (CH) is associated with glaucomatous structural changes. We retrospectively investigated the association between CH and the regional circumpapillary retinal nerve fibre layer thickness (cpRNFLT) in 419 eyes of 419 patients with normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG). CH was used as the explanatory variable, and cpRNFLT (total and quadrant) was used as the dependent variable. Standardized β coefficients were compared both overall and between the NTG and POAG groups. Multiple regression analysis with CH as the explanatory variable and cpRNFLT parameters as the dependent variables suggested that even after adjusting for age, sex, intraocular pressure (IOP), axial length, and central corneal thickness, all areas of the cpRNFLT were significantly associated with CH, except for the nasal quadrant. In the stratified analysis by glaucoma type, a positive relationship between CH and regional cpRNFLT tended to be maintained in the NTG group but not in the POAG group (P = 0.060 for interaction). Additionally, in the NTG group, the CH-inferior cpRNFLT relationship was particularly strong in the less-IOP fluctuation group. These results suggest that CH may be a potential predictor of anatomical vulnerability around the optic nerve, particularly enhancing the inferior regions of NTG.
正常眼圧緑内障における角膜ヒステレシスと視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
開放隅角緑内障における乳頭黄斑神経線維束厚と中心視野との関連に影響する因子

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
眼底写真の緑内障スクリーニングAIを用いた市民イベントでの検証

二宮高洋, 檜森紀子, Parmanand Sharma, 鈴木啓太, 木川勉, 野口祥太郎, 野崎貴成, 藤原啓, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　76-76　2024/09
Publisher: 日本緑内障学会
正常眼圧緑内障における角膜ヒステレシスと視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
開放隅角緑内障における乳頭黄斑神経線維束厚と中心視野との関連に影響する因子

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　70-70　2024/09
Publisher: 日本緑内障学会
眼底写真の緑内障スクリーニングAIを用いた市民イベントでの検証

二宮高洋, 檜森紀子, Parmanand Sharma, 鈴木啓太, 木川勉, 野口祥太郎, 野崎貴成, 藤原啓, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　35回　76-76　2024/09
Publisher: 日本緑内障学会
Differentiating optic neuropathies using laser speckle flowgraphy: Evaluating blood flow patterns in the optic nerve head and peripapillary choroid. International-journal

Chiaki Yamaguchi, Naoki Kiyota, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

Acta ophthalmologica　2024/08/13

DOI： 10.1111/aos.16747 　

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PURPOSE: To compare blood flow (BF) impairment patterns in different optic neuropathies using laser speckle flowgraphy (LSFG). METHODS: This retrospective study enrolled 24 eyes of 24 patients with non-arteritic anterior ischemic optic neuropathy (NAAION), 59 eyes of 59 patients with optic neuritis (ON), 677 eyes of 677 patients with open-angle glaucoma (OAG), and 110 eyes of 110 controls. The patient backgrounds of all groups were compared. Ophthalmologic findings were evaluated, adjusting for age, sex, blood pressure, pulse rate, and underlying systemic diseases with 1:1 optimal propensity score matching. We used LSFG to obtain optic nerve head (ONH) vessel-area mean blur rate (MBR; ONH-MV), ONH tissue-area MBR (ONH-MT), and choroidal MBR. The NAAION and ON groups were compared with the control and OAG groups. RESULTS: Best-corrected visual acuity was worse in the NAAION, ON, and OAG groups than in controls (p < 0.001). Circumpapillary retinal nerve fibre layer thickness was higher in the NAAION and ON groups and lower in the OAG group than in controls (p < 0.001). Compared to controls, the NAAION and OAG groups had significantly lower ONH-MV, ONH-MT, and choroidal MBR (p < 0.05). Additionally, the NAAION group had lower ONH-MV and choroidal MBR than the OAG group (p = 0.003 and p < 0.001, respectively) but no difference in ONH-MT (p = 0.857). The ON group had significantly lower ONH-MV and choroidal MBR compared to the controls (p < 0.001 and p = 0.022, respectively) but no difference in ONH-MT (p = 0.773). CONCLUSION: Optic neuropathies showed different patterns of ocular BF impairment. Therefore, LSFG can be a useful tool for differentiating optic neuropathies.
The relationship between equol production status and normal tension glaucoma. International-journal

Noriko Himori, Keiko Uchida, Takahiro Ninomiya, Masashi Nagai, Kota Sato, Satoru Tsuda, Kazuko Omodaka, Toru Nakazawa

International ophthalmology　44　(1)　287-287　2024/06/27

DOI： 10.1007/s10792-024-03225-3 　

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PURPOSE: Equol is metabolized by intestinal bacteria from soy isoflavones and is chemically similar to estrogen. Dietary habits, such as consumption of soy products, influence equol production. A relationship between glaucoma and estrogen has been identified; here, we investigated the relationship between equol production status and glaucoma in Japan. METHODS: We recruited 68 normal-tension glaucoma (NTG) patients (male to female ratio 26:42, average age 63.0 ± 7.6 years) and 31 controls (male to female ratio 13:18, average age 66.0 ± 6.3 years) from our hospital. All women included were postmenopausal. Urinary equol concentration was quantified with the ELISA method. MD was calculated based on the Humphrey visual field. The association between MD and equol was analyzed with Spearman's rank correlation coefficient. The Mann-Whitney U test was used to compare the equol-producing (> 1 μM) and non-producing (< 1 μM) subjects. We also investigated the association between equol and glaucoma with a logistic regression analysis. RESULTS: There was a significant association between equol and MD (r = 0.36, P < 0.01) in the NTG patients. Glaucoma, represented by MD, was significantly milder in the equol-producing subjects than the non-equol producing subjects (P = 0.03). A multivariate analysis revealed the independent contributions of equol, cpRNFLT, and IOP to MD (P = 0.03, P = 0.04, and P < 0.01, respectively). CONCLUSION: Our results suggest that equol, acting through estrogen receptor-mediated neuroprotective effects, might be involved in suppressing the progression of NTG. This result also adds to evidence that glaucoma may be influenced by lifestyle.
Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma.

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Toru Nakazawa

Japanese journal of ophthalmology　2024/05/30

DOI： 10.1007/s10384-024-01071-5 　

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PURPOSE: This study aimed to investigate differences in microvasculature dropout (MvD) between the superior and inferior hemispheres in glaucoma patients. STUDY DESIGN: Retrospective and cross-sectional. METHODS: Fifty-eight eyes of 58 open-angle glaucoma patients (age 61.12 ± 10.19 years, mean deviation - 7.32 ± 6.36 dB) were included. MvD was detected with en face images from swept-source optical coherence tomography angiography. Blood flow at the optic nerve head was measured with laser speckle flowgraphy, represented as the mean blur rate in tissue (MBRT). Logistic and linear regression models adjusted for age, intraocular pressure, axial length, and circumpapillary retinal nerve fiber layer thickness were used to investigate the relationship between various factors and MvD angle in each hemisphere. RESULTS: The presence of inferior MvD was related to peripapillary atrophy-β area (odds ratio = 14.10 [2.49-234.00], P = 0.019). Superior MvD angle was significantly related to MBRT in the superior quadrant (β = -0.31 [- 0.60 - -0.02], P = 0.037). Inferior MvD angle was significantly related to peripapillary atrophy-β area (β = 0.49 [0.21-0.77], P = 0.001). CONCLUSIONS: Only superior MvD demonstrated a significant relationship with reduced ocular blood flow. In contrast, inferior MvD was associated with mechanical stress. These findings may suggest a potential difference in pathophysiology between superior and inferior MvD.
Sector-specific association of intraocular pressure dynamics in dark-room prone testing and visual field defect progression in glaucoma. International-journal

Masataka Sato, Naoki Kiyota, Takeshi Yabana, Shigeto Maekawa, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

Ophthalmology. Glaucoma　2024/03/28

DOI： 10.1016/j.ogla.2024.03.007 　

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PURPOSE: To investigate sectoral differences in the relationship between intraocular pressure (IOP) dynamics during dark-room prone testing (DRPT) and visual field (VF) defect progression in primary open-angle glaucoma (POAG) patients. DESIGN: Retrospective, longitudinal study PARTICIPANTS: This retrospective study included 116 eyes of 84 POAG patients who underwent DRPT and had at least five reliable VF tests conducted over a more than two-year follow-up period. We excluded eyes with mean deviation worse than -20 dB or a history of intraocular surgery or laser treatment. METHODS: Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 or 30-2 program. During DRPT, IOP was measured in the sitting position, and after 60 minutes in the prone position in a dark room, IOP was measured again. The relationship between IOP change during DRPT, IOP after DRPT, and TD slope in each quadrant was analyzed with a linear mixed-effects model, adjusting for other potential confounding factors. MAIN OUTCOME MEASURES: TD slope in each quadrant, IOP change during DRPT, and IOP after DRPT RESULTS: IOP after DRPT and IOP change during DRPT were 18.16±3.42 mmHg and 4.92±3.12 mmHg, respectively. Superior TD slope was significantly associated with both IOP after DRPT (β=-0.28, p=0.003) and IOP change during DRPT (β=-0.21, p=0.029), while central (β=-0.05, p=0.595; β=-0.05; p=0.622) and inferior (β=0.05, p=0.611; β=0.01, p=0.938) TD slopes were not. CONCLUSION: DRPT might be a useful test to predict the risk of superior VF defect progression in eyes with POAG.
Laser speckle flowgraphyを用いた視神経炎病態別の眼内血流評価について

山口知暁, 檜森紀子, 清田直樹, 大島隆寛, 木村暸, 津田聡, 面高宗子, 三須建郎, 青木正志, 中澤徹

日本眼科学会雑誌　128　(臨増)　193-193　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Laser speckle flowgraphyを用いた視神経炎病態別の眼内血流評価について

山口知暁, 檜森紀子, 清田直樹, 大島隆寛, 木村暸, 津田聡, 面高宗子, 三須建郎, 青木正志, 中澤徹

日本眼科学会雑誌　128　(臨増)　193-193　2024/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Author Correction: Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

npj aging　10　(1)　8-8　2024/01/20

DOI： 10.1038/s41514-024-00137-5 　
The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study. International-journal

Naoki Kiyota, Yukihiro Shiga, Takahiro Ninomiya, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Kyongsun Pak, Toru Nakazawa

Advances in therapy　2024/01/02

DOI： 10.1007/s12325-023-02762-0 　

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INTRODUCTION: Our study was conducted to determine factors associated with the effectiveness of a β-blocker eye drop add-on in altering pulse rate (PR) in glaucoma patients. METHODS: This retrospective study examined 236 eyes of 138 patients who received a β-blocker eye drop add-on during follow-up. Patients were included if at least one PR measurement was available both before and after the add-on was started. We collected data on ophthalmic parameters: longitudinal PR; longitudinal choroidal blood flow, represented by laser speckle flowgraphy-measured mean blur rate (MBR); and diacron-reactive oxygen metabolites (d-ROMs). We used a multivariable linear mixed-effects model to investigate the effectiveness of the β-blocker eye drop add-on in altering PR and examined factors contributing to a larger PR alteration after the add-on was started by analyzing the effect on PR of the interaction term between the add-on and clinical factors. We used the k-means method to classify the patients. RESULTS: The β-blocker eye drop add-on reduced PR (- 7.61 bpm, P < 0.001). Female gender, higher PR when the add-on was started, lower central corneal thickness, and a higher d-ROM level were associated with greater reduction in PR (P < 0.05). In a cluster of patients with these clinical features, choroidal MBR increased by + 3.42% when we adjusted for change over time; MD slope, which represents the speed of glaucoma progression, improved by + 0.64 dB/year (P < 0.05). CONCLUSIONS: We identified a glaucoma subgroup in which PR decreased, choroidal blood flow increased, and glaucoma progression slowed after a β-blocker eye drop add-on was started.
The Relationship Between Artificial Intelligence-Assisted OCT Angiography-Derived Foveal Avascular Zone Parameters and Visual-Field Defect Progression in Eyes with Open-Angle Glaucoma. International-journal

Takahiro Ninomiya, Naoki Kiyota, Parmanand Sharma, Kazuko Omodaka, Noriko Himori, Masayuki Yasuda, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology science　4　(2)　100387-100387　2024

DOI： 10.1016/j.xops.2023.100387 　

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PURPOSE: To investigate clinical factors associated with foveal avascular zone (FAZ) parameters obtained using OCT angiography (OCTA) with assistance from a previously developed artificial intelligence (AI) platform in eyes with open-angle glaucoma (OAG). DESIGN: Retrospective longitudinal. PARTICIPANTS: This study followed up 885 eyes of 558 patients with OAG for ≥ 2 years; all eyes underwent ≥ 5 Humphrey visual-field (VF) tests and had 3.0 × 3.0 mm macular OCTA scans available. METHODS: Average total deviation (TD) in the superior, superocentral, inferocentral, and inferior sectors of the Humphrey 24-2 program was calculated. We collected 3.0 × 3.0 mm macular OCTA images from each patient and used a previously developed AI platform with these images to obtain FAZ parameters, including FAZ area, FAZ circularity index (CI), and FAZ perimeter. Multivariable linear mixed-effects models were used to analyze the relationship between FAZ parameters, TD or TD slope in each quadrant, and systemic factors, adjusting for potential confounding factors, including axial length. MAIN OUTCOME MEASURES: Ophthalmic and systemic variables, FAZ parameters, and TD or TD slope in each quadrant. RESULTS: The multivariable model showed that FAZ parameters were correlated with both TD and TD slope in the inferocentral quadrant (β = -0.244 - 0.168, P < 0.001). Both upper-half and lower-half FAZ parameters were better associated with TD-inferocentral and TD-inferocentral slope than TD-superocentral or TD-superocentral slope in terms of β size and statistical significance, indicating that there was no evident vertical anatomical correspondence between TD in the central quadrant and FAZ parameters. Foveal avascular zone area enlargement was associated with female gender (β = 0.242, P = 0.003). Loss of FAZ circularity was associated with both aging and comorbid sleep apnea syndrome (SAS) (yes: 1, no: 0) (β = -0.188, P < 0.001; β = -0.261, P = 0.031, respectively). Foveal avascular zone perimeter elongation was associated with aging and female gender (β = 0.084, P = 0.040; β = 0.168, P = 0.042, respectively). CONCLUSIONS: Artificial intelligence-assisted OCTA-measured FAZ enlargement and irregular shape might be good markers of ocular hypoperfusion and associated inferocentral VF defect progression in eyes with OAG. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study

Naoki Kiyota, Yukihiro Shiga, Takahiro Ninomiya, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Kyongsun Pak, Toru Nakazawa

Advances in Therapy　2024

DOI： 10.1007/s12325-023-02762-0 　

ISSN： 0741-238X

eISSN： 1865-8652
Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. International-journal

Kota Sato, Daisuke Saigusa, Taiki Kokubun, Amane Fujioka, Qiwei Feng, Ritsumi Saito, Akira Uruno, Naomi Matsukawa, Michiko Ohno-Oishi, Hiroshi Kunikata, Yu Yokoyama, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Satoru Tsuda, Shigeto Maekawa, Masayuki Yamamoto, Toru Nakazawa

npj aging　9　(1)　28-28　2023/11/21

DOI： 10.1038/s41514-023-00124-2 　

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Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to understand physiological and pathological conditions in the eye. In the current study, we used mass spectrometry (MS) to characterize the aqueous humor metabolomic profile and biological features of patients with glaucoma. Aqueous humor samples were collected during trabeculectomy surgery or cataract surgery and analyzed with global metabolomics. We included 40 patients with glaucoma (32 with POAG, 8 with NTG) and 37 control subjects in a discovery study. VIP analysis revealed five metabolites that were elevated and three metabolites that were reduced in the glaucoma patients. The identified metabolomic profile had an area under the receiver operating characteristic curve of 0.953. Among eight selected metabolites, the glutathione level was significantly decreased in association with visual field defects. Moreover, in a validation study to confirm the reproducibility of our findings, the glutathione level was reduced in NTG and POAG patients compared with a cataract control group. Our findings demonstrate that aqueous humor profiling can help to diagnose glaucoma and that various aqueous humor metabolites are correlated with clinical parameters in glaucoma patients. In addition, glutathione is clearly reduced in the aqueous humor of glaucoma patients with both IOP-dependent and IOP-independent disease subtypes. These findings indicate that antioxidant agents in the aqueous humor reflect glaucomatous optic nerve damage and that excessive oxidative stress may be involved in the pathogenesis of glaucoma.
The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury

Kota Sato, Michiko Ohno-Oishi, Masaaki Yoshida, Taimu Sato, Takaharu Aizawa, Yuto Sasaki, Shigeto Maekawa, Makoto Ishikawa, Kazuko Omodaka, Chihiro Kawano, Ryuji Ohue-Kitano, Ikuo Kimura, Toru Nakazawa

GLIA　71　(11)　2609-2622　2023/11

DOI： 10.1002/glia.24442 　

ISSN： 0894-1491

eISSN： 1098-1136
The association between intraocular pressure dynamics during dark-room prone testing and intraocular pressure over a relatively long-term follow-up period in primary open-glaucoma patients. International-journal

Masataka Sato, Naoki Kiyota, Takeshi Yabana, Shigeto Maekawa, Satoru Tsuda, Kazuko Omodaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　2023/10/21

DOI： 10.1007/s00417-023-06257-0 　

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PURPOSE: To investigate the relationship between the dynamics of intraocular pressure (IOP) during dark-room prone testing (DRPT) and IOP over a relatively long-term follow-up period. METHODS: This retrospective study enrolled 84 eyes of 51 primary open-angle glaucoma patients who underwent DRPT for whom at least three IOP measurements made using Goldmann applanation tonometry were available over a maximum follow-up period of two years. We excluded eyes with a history of intraocular surgery or laser treatment and those with changes in topical anti-glaucoma medication during the follow-up period. In DRPT, IOP was measured in the sitting position, and after 60 min in the prone position in a dark room, IOP was measured again. In this study, IOP fluctuation refers to the standard deviation (SD) of IOP, and IOP max indicates the maximum value of IOP during the follow-up. The relationship between these parameters was analyzed with a linear mixed-effects model, adjusting for clinical parameters including age, gender, and axial length. RESULTS: IOP increased after DRPT with a mean of 6.13 ± 3.55 mmHg. IOP max was significantly associated with IOP after DRPT (β = 0.38; p < 0.001). IOP fluctuation was significantly associated with IOP change in DRPT (β = 0.29; p = 0.007). CONCLUSION: Our findings suggest that short-term and relatively long-term IOP dynamics are associated. Long-term IOP dynamics can be predicted by DRPT to some extent.
Factors associated with intrachoroidal cavitation and sinkhole formation in eyes with glaucomatous visual-field defects. International-journal

Chiaki Yamaguchi, Naoki Kiyota, Naoki Takahashi, Yoko Takeda, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie　2023/10/04

DOI： 10.1007/s00417-023-06247-2 　

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PURPOSE: To investigate factors associated with intrachoroidal cavitation (ICC) and sinkhole formation in eyes with glaucomatous visual-field defects. METHODS: This retrospective, cross-sectional study enrolled a total of 2808 eyes of 1482 patients who were diagnosed/treated for glaucoma and underwent swept-source optical coherence tomography (OCT). We first determined the prevalence of ICCs and sinkholes and their locations. Next, we selected one eye from each patient and compared the clinical characteristics of eyes with and without ICCs. Finally, in eyes with ICCs, we compared the clinical characteristics of eyes with and without sinkholes. Blood flow (BF), represented by laser speckle flowgraphy-measured tissue-area mean blur rate (MBR), was measured in the temporal optic nerve head (ONH), temporal peripapillary chorioretinal atrophy (PPA) zone, and in the ICC zone. ICC area and angle were analyzed in OCT en-face images. Mean deviation and total deviation in the central area (TD-central) were measured with Humphrey visual-field testing. RESULTS: A total of 86 eyes (3.1%) had ICCs and 52 eyes (1.9%) had sinkholes. ICC eyes had a lower spherical equivalent and longer axial length (AL) than non-ICC eyes (P < 0.05). Patients with eyes with sinkholes were more elderly and had worse best-corrected visual acuity, worse TD-central, a larger ICC, and lower tissue-area MBR in the temporal ONH, temporal PPA zone, and ICC zone (P < 0.05). CONCLUSION: In eyes with glaucoma, AL elongation might be linked to ICC formation. Sinkhole formation might be associated with ICC enlargement, impaired ocular BF, and impaired retinal structure and function involving the central area.
Predictive potential of optical coherence tomography parameters for the prognosis of decreased visual acuity after trabeculectomy in open-angle glaucoma patients with good vision. International-journal

Yoko Takeda, Naoki Takahashi, Naoki Kiyota, Taiki Kokubun, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Toru Nakazawa

BMC ophthalmology　23　(1)　399-399　2023/10/04

DOI： 10.1186/s12886-023-03145-3 　

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BACKGROUND: Trabeculectomy (trab) is the most effective surgical procedure for lowering IOP and preventing glaucoma progression. However, decline in best-corrected visual acuity (BCVA) is one of the most serious postoperative complications of trab. Here, we investigated methods to predict decreased BCVA after trab in glaucoma patients with good preoperative BCVA. METHODS: This study included 35 eyes of 35 open-angle glaucoma (OAG) patients (male / female: 21 / 14, age: 64.0 ± 9.7 years old, preoperative intraocular pressure: 15.9 ± 5.4 mmHg, mean deviation: -18.1 ± 5.6 dB) with preoperative BCVA of 0.7 or better who underwent trab and were observed for more than 12 months. As a preoperative analysis, we measured temporal quadrant circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and ganglion cell complex thickness in a central strip between the disc and fovea (csGCCT), an area that corresponds to the location of the papillomacular bundle (PMB) in swept-source optical coherence tomography (OCT). We defined BCVA decline as a loss of more than 3 lines of BCVA after 12 months. Measurement parameters were compared between the BCVA-decline group and the non-BCVA-decline group. RESULTS: BCVA decline was detected in 11 cases (31.4%) 12 months after trab. There was a statistically significant difference in axial length (P = 0.049). A single logistic analysis showed that the BCVA-decline group had significantly lower cpRNFLT than the non-BCVA-decline group (27.7 ± 8.0 μm vs. 45.1 ± 5.3 μm, P < 0.001, cut-off value: 33.4 μm), as well as lower csGCCT (72.4 ± 7.7 μm vs. 87.5 ± 5.1 μm, P = 0.002, cut-off value: 82.3 μm). Multivariable logistic analysis showed that the BCVA-decline group had significantly lower temporal quadrant cpRNFLT (P < 0.001) and lower middle csGCCT (P < 0.001) compared to the non-BCVA-decline group. CONCLUSIONS: Lower temporal quadrant cpRNFLT and middle csGCCT, OCT scan areas that correspond to the location of the PMB, might be biomarkers that predict BCVA decline after trab in OAG patients with good vision.
開放隅角緑内障における角膜ヒステレシスと部位別に見た視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　34回　155-155　2023/09
Publisher: 日本緑内障学会
緑内障眼における暗所うつむき負荷試験前後の眼圧と視野障害進行との関連性における視野セクター別の差異

佐藤正隆, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 檜森紀子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　148-148　2023/09
Publisher: 日本緑内障学会
VBMを用いた緑内障患者における局所脳体積の経時的変化と眼パラメーターの関連

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
緑内障患者における機械学習を用いた睡眠時無呼吸症候群の予測

山崎舞, 檜森紀子, 二宮高洋, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　197-197　2023/09
Publisher: 日本緑内障学会
緑内障眼における暗所うつむき負荷試験前後の眼圧と視野障害進行との関連性における視野セクター別の差異

佐藤正隆, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 檜森紀子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　148-148　2023/09
Publisher: 日本緑内障学会
開放隅角緑内障における角膜ヒステレシスと部位別に見た視神経乳頭周囲網膜神経線維層厚の関連の検討

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本緑内障学会抄録集　34回　155-155　2023/09
Publisher: 日本緑内障学会
VBMを用いた緑内障患者における局所脳体積の経時的変化と眼パラメーターの関連

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
緑内障患者における機械学習を用いた睡眠時無呼吸症候群の予測

山崎舞, 檜森紀子, 二宮高洋, 清田直樹, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　34回　197-197　2023/09
Publisher: 日本緑内障学会
The relationship between Kiritsu-Meijin-derived autonomic function parameters and visual-field defects in eyes with open-angle glaucoma. International-journal

Yurina Yamada, Naoki Kiyota, Mitsuhide Yoshida, Kazuko Omodaka, Toru Nakazawa

Current eye research　1-12　2023/07/05

DOI： 10.1080/02713683.2023.2234105 　

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Purpose: This retrospective cross-sectional study aimed to investigate the association between autonomic parameters measured using the Kiritsu-Meijin device and visual-field defects in patients with open-angle glaucoma (OAG).Methods: A total of 79 eyes of 42 patients with OAG were enrolled in this study. Kiritsu-Meijin testing comprised three phases: sitting, standing, and sitting again (2 minutes, 2 minutes, and 1 minute, respectively). Continuous electrocardiograms were recorded for five minutes. Autonomic parameters were extracted from the resulting data and analyzed, including activity, balance, reaction, switchover, and recovery; these are 5 representative parameters derived from Kiritsu-Meijin testing. Correlations between these parameters and mean deviation (MD) from Humphrey visual field testing were determined. Additionally, we used a linear mixed-effects model to observe sectoral differences in the relationship between TD and the Kiritsu-Meijin parameters. In this study, we focused on superior, central, and inferior TD.Results: Significant positive correlations were observed between activity, balance, and recovery and MD values (β = 0.29-0.38, P < 0.05). The β value between activity and inferior TD was higher than that between activity and superior TD (β = 0.22, P < 0.05). Balance did not show any sectoral differences (P > 0.05). Recovery was more strongly associated with central to inferior TD than superior TD (β = 0.17-0.25, P < 0.05).Conclusion: Our findings suggest that in patients with OAG, lower activity and recovery are associated with more severe central and/or inferior visual field defects in the superior quadrant. These results imply that measurements of autonomic function made with the Kiritsu-Meijin device may have clinical utility in the management of glaucoma.
Factors Associated With Visual Acuity Decline in Glaucoma Patients With Loss of Ganglion Cell Complex Thickness. International-journal

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori, Toru Nakazawa

Translational vision science & technology　12　(7)　2-2　2023/07/03

DOI： 10.1167/tvst.12.7.2 　

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PURPOSE: To investigate the association between ocular/systemic factors and visual acuity decline in glaucoma patients with loss of ganglion cell complex thickness (GCCT). METHODS: In 515 eyes of 515 patients with open-angle glaucoma (mean age, 62.6 ± 12.8 years; mean deviation, -10.95 ± 9.07 dB), we used swept-source optical coherence tomography to measure macular GCCT in sectors classified as corresponding to circumpapillary retinal nerve fiber layer clock-hour sectors from 7 o'clock (inferotemporal) to 11 o'clock (superotemporal). We calculated Spearman's rank correlation coefficient between each sector and best-corrected visual acuity (BCVA), determined cutoff values for BCVA decline (<20/25), and used multivariable linear regression models to determine the correlation between BCVA and biological antioxidant potential (BAP), corneal hysteresis (CH), and temporal-tissue optic nerve head blood flow (represented by temporal mean blur rate, or MBR-T). RESULTS: Macular GCCT corresponding to the 9 o'clock sector had the highest correlation with BCVA (Rs = -0.454; P < 0.001) and a cutoff of 76.17 µm (area under the receiver operating characteristic curve = 0.891; P < 0.001). Subjects below this cutoff (N = 173) showed significant correlations between BCVA and age, BAP, CH, and MBR-T (β = 0.192, P = 0.033; β = -0.186, P = 0.028; β = -0.217, P = 0.011; and β = -0.222, P = 0.010, respectively). CONCLUSIONS: Multiple factors are involved in BCVA decline in patients with glaucoma with decreased macular GCCT. This suggests that evaluating BCVA may require assessing multiple factors. TRANSLATIONAL RELEVANCE: Multiple factors contribute to BCVA decline.
Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma. International-journal

Kota Sato, Naoko Takada, Amane Fujioka, Noriko Himori, Yu Yokoyama, Satoru Tsuda, Kazuko Omodaka, Tomoko Kirihara, Makoto Ishikawa, Hiroshi Kunikata, Toru Nakazawa

Journal of glaucoma　2023/06/19

DOI： 10.1097/IJG.0000000000002257 　

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AIMS: To evaluate differences in systemic BDNF levels between primary open-angle glaucoma (POAG) patients and normal-tension glaucoma (NTG) patients. METHODS: This study collected blood samples from 260 NTG patients, 220 age-matched POAG patients, and 120 age-matched cataract patients (as controls). BDNF levels were measured with an antibody-conjugated bead assay system (Luminex). RESULTS: We found that plasma BDNF levels in the NTG group were significantly lower than in the POAG and cataract control groups. There was no significant difference between the POAG and cataract groups. CONCLUSION: This result suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner.
Deep Learning-Based Noise Reduction Improves Optical Coherence Tomography Angiography Imaging of Radial Peripapillary Capillaries in Advanced Glaucoma. International-journal

Kazuko Omodaka, Juun Horie, Hikari Tokairin, Chiho Kato, Junko Ouchi, Takahiro Ninomiya, Sharma Parmanand, Satoru Tsuda, Toru Nakazawa

Current eye research　1-9　2022/09/22

DOI： 10.1080/02713683.2022.2124275 　

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PURPOSE: We applied deep learning-based noise reduction (NR) to optical coherence tomography-angiography (OCTA) images of the radial peripapillary capillaries (RPCs) in eyes with glaucoma and investigated the usefulness of this method as an objective analysis of glaucoma. METHODS: This cross-sectional study included 118 eyes of 94 open-angle glaucoma patients (male/female = 38/56, age: 56.1 ± 10.3 years). We used OCTA (OCT-HS100, Canon) and built-in software (RX software, v. 4.5) to perform NR and calculate RPC vessel area density (VAD) and skeleton vessel length density (VLD). We also examined NR's effect on reproducibility. Finally, we assessed the vascular structure (PRCs)/function relationship at different glaucoma stages with Spearman's correlation. RESULTS: Regardless of NR, RPC parameters had excellent coefficients of variation (1.7-4.1%) in glaucoma patients and controls, and mean deviation (MD) was significantly correlated with VAD (NR: r = 0.835, p < 0.001; non-NR: r = 0.871, p < 0.001) and VLD (NR: r = 0.829, p < 0.001; non-NR: r = 0.837, p < 0.001). For mild, moderate, and advanced glaucoma, the correlation coefficients between MD and VLD were 0.366 (p = 0.028) 0.081 (p = 0.689), and 0.427 (p = 0.017) with NR and 0.405 (p = 0.014), 0.184 (p = 0.360), and 0.339 (p = 0.062) without NR, respectively. CONCLUSION: Denoised RPC images might have the potential for a closer structural/functional relationship, in which the floor effect of retinal nerve fiber layer thickness affects measurements. Deep learning-based NR promises to improve glaucoma assessment.
Clinical characteristics of glaucoma patients with various risk factors. International-journal

Kazuko Omodaka, Tsutomu Kikawa, Sayaka Kabakura, Noriko Himori, Satoru Tsuda, Takahiro Ninomiya, Naoki Takahashi, Kyongsun Pak, Noriyasu Takeda, Masahiro Akiba, Toru Nakazawa

BMC ophthalmology　22　(1)　373-373　2022/09/19

DOI： 10.1186/s12886-022-02587-5 　

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BACKGROUND: Glaucoma is multifactorial, but the interrelationship between risk factors and structural changes remains unclear. Here, we adjusted for confounding factors in glaucoma patients with differing risk factors, and compared differences in structure and susceptible areas in the optic disc and macula. METHODS: In 458 eyes with glaucoma, we determined confounding factors for intraocular pressure (IOP), central corneal thickness (CCT), axial length (AL), LSFG-measured ocular blood flow (OBF), which was assessed with laser speckle flowgraphy-measured mean blur rate in the tissue area (MT) of the optic nerve head, biological antioxidant potential (BAP), and systemic abnormalities in diastolic blood pressure (dBP). To compensate for measurement bias, we also analyzed corrected IOP (cIOP; corrected for CCT) and corrected MT (cMT; corrected for age, weighted retinal ganglion cell count, and AL). Then, we determined the distribution of these parameters in low-, middle-, and high-value subgroups and compared them with the Kruskal-Wallis test. Pairwise comparisons used the Steel-Dwass test. RESULTS: The high-cIOP subgroup had significantly worse mean deviation (MD), temporal, superior, and inferior loss of circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and large cupping. The low-CCT subgroup had temporal cpRNFLT loss; the high-CCT subgroup had low cup volume. The high-AL subgroup had macular ganglion cell complex thickness (GCCT) loss; the low-AL subgroup had temporal cpRNFLT loss. The high-systemic-dBP subgroup had worse MD, total, superior, and inferior cpRNFLT loss and macular GCCT loss. The low-BAP subgroup had more male patients, higher dBP, and cpRNFLT loss in the 10 o'clock area. The high-OBF subgroup had higher total, superior and temporal cpRNFLT and macular GCCT. CONCLUSIONS: Structural changes and local susceptibility to glaucomatous damage show unique variations in patients with different risk factors, which might suggest that specific risk factors induce specific types of pathogenesis and corresponding glaucoma phenotypes. Our study may open new avenues for the development of precision medicine for glaucoma.
The relationship between choroidal blood flow and glaucoma progression in a Japanese study population.

Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Japanese journal of ophthalmology　2022/07/05

DOI： 10.1007/s10384-022-00929-w 　

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PURPOSE: To determine whether choroidal blood flow (BF) is related to visual field (VF) defect severity and progression in eyes with open-angle glaucoma (OAG). STUDY DESIGN: Retrospective and longitudinal. METHODS: This study comprised 443 eyes of 285 OAG patients who underwent laser speckle flowgraphy (LSFG), optical coherence tomography, and visual-field (VF) testing at baseline. The patients were then observed for at least 2 years and at least 5 reliable VF tests were performed. In the LSFG images, we set regions of interest at the optic nerve head (ONH) and the parapapillary choroid to obtain ONH-tissue mean blur rate (MBR) and choroidal MBR, respectively. We used univariable and multivariable linear mixed-effects models to determine clinical factors associated with choroidal MBR at baseline. We also used a linear mixed-effects model to determine the contribution of ONH-tissue MBR and choroidal MBR to baseline mean deviation (MD) and to MD slope during follow-up, adjusting for potential confounding factors, including circumpapillary retinal nerve fiber layer thickness. RESULTS: Choroidal MBR was associated with age, MD slope, and ONH-tissue MBR (β = -0.181, P = 0.001; β = 0.134, P = 0.002; β = 0.096, P = 0.049, respectively). ONH-tissue MBR was associated with both MD and MD slope (β = 0.146, P = 0.004; β = 0.152, P = 0.009, respectively), whereas choroidal MBR was associated only with MD slope (β = 0.147, P = 0.005). CONCLUSION: LSFG-derived choroidal MBR might be a useful biomarker to predict VF defect progression in a Japanese population.
Correlation Between Enlargement of Retinal Nerve Fiber Defect Angle in En Face Imaging and Visual Field Progression. International-journal

Naoki Takahashi, Kazuko Omodaka, Arata Nakazawa, Tsutomu Kikawa, Takahiro Ninomiya, Naoki Kiyota, Satoru Tsuda, Noriko Himori, Masahiro Akiba, Toru Nakazawa

Translational vision science & technology　11　(6)　8-8　2022/06/01

DOI： 10.1167/tvst.11.6.8 　

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Purpose: Retinal nerve fiber layer defects (RNFLDs) become enlarged with glaucoma progression. We measured the RNFLD angle and investigated whether it was correlated with deterioration of the visual field in patients with glaucoma. Methods: This study included 84 eyes of 84 patients with open-angle glaucoma (mean deviation [MD] = -6.51 ± 5.91 dB, follow-up period = 2.82 ± 0.74 years) with the RNFLDs, who underwent en face swept-source optical coherence tomography (SS-OCT) wide scans (12 × 9 mm) at least 6 times. The RNFLD angle was measured as the intersection between the RNFLD and a circle centered on the disc with a radius half the distance between the disc and the fovea. Slopes for the RNFLD angle, macular ganglion cell layer thickness (GCCT), and circumpapillary RNFL thickness (cpRNFLT) were compared with the MD slope, as measured with the Humphrey field analyzer 24-2 program. Results: The correlation coefficients with MD slope were -0.67 for the RNFLD angle slope (P < 0.001), 0.15 for the macular GCCT slope (P = 0.163), and 0.04 for the cpRNFLT slope (P = 0.719). The RNFLD angle tended to increase as the number of disc hemorrhage occurrences increased (rs = 0.31, P = 0.004). The RNFLD angle slope also had good predictive power for glaucoma progression (area under the receiver operating characteristic curve = 0.88, 95% confidence interval = 0.81-0.95). Conclusions: We found that the RNFLD angle slope was more closely associated with the MD slope than were other OCT parameters. This suggests that measurement of the RNFLD angle with en face OCT images could be effective in evaluating glaucoma progression. Translational Relevance: Our study provides a method for monitoring glaucoma progression with SS-OCT.
A lightweight deep learning model for automatic segmentation and analysis of ophthalmic images. International-journal

Parmanand Sharma, Takahiro Ninomiya, Kazuko Omodaka, Naoki Takahashi, Takehiro Miya, Noriko Himori, Takayuki Okatani, Toru Nakazawa

Scientific reports　12　(1)　8508-8508　2022/05/20

DOI： 10.1038/s41598-022-12486-w 　

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Detection, diagnosis, and treatment of ophthalmic diseases depend on extraction of information (features and/or their dimensions) from the images. Deep learning (DL) model are crucial for the automation of it. Here, we report on the development of a lightweight DL model, which can precisely segment/detect the required features automatically. The model utilizes dimensionality reduction of image to extract important features, and channel contraction to allow only the required high-level features necessary for reconstruction of segmented feature image. Performance of present model in detection of glaucoma from optical coherence tomography angiography (OCTA) images of retina is high (area under the receiver-operator characteristic curve AUC ~ 0.81). Bland-Altman analysis gave exceptionally low bias (~ 0.00185), and high Pearson's correlation coefficient (p = 0.9969) between the parameters determined from manual and DL based segmentation. On the same dataset, bias is an order of magnitude higher (~ 0.0694, p = 0.8534) for commercial software. Present model is 10 times lighter than Unet (popular for biomedical image segmentation) and have a better segmentation accuracy and model training reproducibility (based on the analysis of 3670 OCTA images). High dice similarity coefficient (D) for variety of ophthalmic images suggested it's wider scope in precise segmentation of images even from other fields. Our concept of channel narrowing is not only important for the segmentation problems, but it can also reduce number of parameters significantly in object classification models. Enhanced disease diagnostic accuracy can be achieved for the resource limited devices (such as mobile phone, Nvidia's Jetson, Raspberry pi) used in self-monitoring, and tele-screening (memory size of trained model ~ 35 MB).
A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice. International-journal

Shigeto Maekawa, Kota Sato, Taiki Kokubun, Noriko Himori, Takeshi Yabana, Michiko Ohno-Oishi, Ge Shi, Kazuko Omodaka, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　16　823-832　2022

DOI： 10.2147/OPTH.S354958 　

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Purpose: To investigate the effect of plant-derived antioxidant compounds, identified with primary culture screening, on retinal ganglion cell (RGC) survival in mice under excitotoxic conditions. Additionally, to determine the effect of these compounds on the involvement of calpain inactivation. Materials and Methods: Plant-derived antioxidant compounds including hesperidin, crocetin, and Tamarindus indica were administrated orally to C57BL/6J mice. The levels of lipid oxidation and calpain activation were assessed with a TBARS assay and western blotting. RGC survival was evaluated with a TUNEL assay and RBPMS immunostaining after intravitreal injection of NMDA. Results: Plant-derived antioxidant compounds significantly ameliorated the increase in the level of MDA in the retinas after NMDA injury. Cleaved α-fodrin fragments were detected in the NMDA-injured retinas, and these fragments were significantly lower in mice that received the plant-derived antioxidant compounds. The plant-derived antioxidants also ameliorated increases in TUNEL-positive cells and RGC death after NMDA injection. Conclusion: These results indicate that oral administration of plant-derived antioxidant compounds such as hesperidin, crocetin, and Tamarindus indica suppressed RGC death. This oral supplementation decreased lipid oxidation and excessive calpain activation in NMDA-injured retinas. Thus, our newly developed antioxidant supplement has a potential role in neuroprotective treatment for retinal diseases, such as glaucoma.
CHOP deletion and anti-neuroinflammation treatment with hesperidin synergistically attenuate NMDA retinal injury in mice. International-journal

Kota Sato, Taimu Sato, Michiko Ohno-Oishi, Mikako Ozawa, Shigeto Maekawa, Yukihiro Shiga, Takeshi Yabana, Masayuki Yasuda, Noriko Himori, Kazuko Omodaka, Kosuke Fujita, Koji M Nishiguchi, Shi Ge, Toru Nakazawa

Experimental eye research　213　108826-108826　2021/12

DOI： 10.1016/j.exer.2021.108826 　

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Glaucoma is a leading cause of blindness worldwide and is characterized by degeneration associated with the death of retinal ganglion cells (RGCs). It is believed that glaucoma is a group of heterogeneous diseases with multifactorial pathomechanisms. Here, we investigate whether anti-inflammation treatment with an ER stress blockade can selectively promote neuroprotection against NMDA injury in the RGCs. Retinal excitotoxicity was induced with an intravitreal NMDA injection. Microglial activation and neuroinflammation were evaluated with Iba1 immunostaining and cytokine gene expression. A stable HT22 cell line transfected with an NF-kB reporter was used to assess NF-kB activity after hesperidin treatment. CHOP-deficient mice were used as a model of ER stress blockade. Retinal cell death was evaluated with a TUNEL assay. As results, in the NMDA injury group, Iba1-positive microglia increased 6 h after NMDA injection. Also at 6 h, pro-inflammatory cytokines and chemokine increased, including TNFα, IL-1b, IL-6 and MCP-1. In addition, the MCP-1 promoter-driven EGFP signal, which we previously identified as a stress signal in injured RGCs, also increased; hesperidin treatment suppressed this inflammatory response and reduced stressed RGCs. In CHOP-deficient mice that received an NMDA injection, the gene expression of pro-inflammatory cytokines, chemokines, markers of active microglia, and inflammatory regulators was greater than in WT mice. In WT mice, hesperidin treatment partially prevented retinal cell death after NMDA injury; this neuroprotective effect was enhanced in CHOP-deficient mice. These findings demonstrate that ER stress blockade is not enough by itself to prevent RGC loss due to neuroinflammation in the retina, but it has a synergistic neuroprotective effect after NMDA injury when combined with an anti-inflammatory treatment based on hesperidin.
Time-Course Changes in Optic Nerve Head Blood Flow and Retinal Nerve Fiber Layer Thickness in Eyes with Open-angle Glaucoma. International-journal

Naoki Kiyota, Yukihiro Shiga, Kazuko Omodaka, Kyongsun Pak, Toru Nakazawa

Ophthalmology　128　(5)　663-671　2021/05

DOI： 10.1016/j.ophtha.2020.10.010 　

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PURPOSE: To determine whether decreased optic nerve head (ONH) blood flow (BF) precedes or follows decreased circumpapillary retinal nerve fiber layer thickness (cpRNFLT) in eyes with open-angle glaucoma (OAG). DESIGN: Retrospective, longitudinal study. PARTICIPANTS: This study followed up 350 eyes of 225 OAG patients for at least 2 years and collected data from each patient from at least 5 examinations obtained with laser speckle flowgraphy (LSFG) and OCT. METHODS: In the superior, temporal, and inferior ONH quadrants, tissue area mean blur rate (MT), representing ONH tissue BF, was measured with LSFG, whereas cpRNFLT was measured with OCT. A multivariate linear mixed-effects model was used to identify potential predictors of faster MT decrease, adjusting for possible confounding factors. Based on these results, each quadrant of each patient was assigned a risk point if the quadrant was the superior or temporal, if patient age was older than the median (61 years), and if patient pulse rate was higher than median (74 beats per minute). The quadrants were then compared with a mixed-effects Cox model for MT and cpRNFLT changes, defined as a difference between the baseline value and the values from the latest 2 consecutive follow-up visits of more than 1.96 × the corresponding coefficient of variation. MAIN OUTCOME MEASURES: Ophthalmic and systemic variables and MT and cpRNFLT in the superior, temporal, and inferior quadrants. RESULTS: The multivariate model showed that MT decrease was faster in older patients with higher pulse rate and slower in inferior quadrants (P < 0.05). Quadrants with 0 risk points showed primary cpRNFLT decrease (P = 0.048), 1-risk point quadrants showed simultaneous cpRNFLT and MT decrease (P = 0.260), and 2-risk point and 3-risk point quadrants showed primary MT decrease (P < 0.001). CONCLUSIONS: Older patients with higher pulse rate are at greater risk of a primary reduction in ONH tissue BF, that is, preceding cpRNFLT decrease, in the superior and temporal quadrants.
Association between Topographic Features of the Retinal Nerve Fiber Bundle and Good Visual Acuity in Patients with Glaucoma. International-journal

Naoki Takahashi, Kazuko Omodaka, Tsutomu Kikawa, Masahiro Akiba, Toru Nakazawa

Current eye research　1-8　2021/04/16

DOI： 10.1080/02713683.2021.1912782 　

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Purpose: Maintaining visual acuity in glaucoma patients is an important part of preventing the deterioration of quality of vision. We identified specific areas of the papillomacular bundle (PMB) that were strongly associated with visual acuity, based on en-face images derived from optical coherence topography (OCT) wide scans.Methods: The study recruited 23 eyes of 21 glaucoma patients (age: 61.3 ± 13.0 years, M: F = 9:12, Humphrey field analyzer-measured mean deviation: -19.9 ± 6.5 dB) with good best-corrected visual acuity (20/20 or more) and a remaining PMB with a maximum width no more than half that of the vertical disc diameter. En-face images were derived from 12 × 9 mm wide-scan images made with DRI-OCT (Triton, Topcon). Averaged en-face images were created by identifying the disc center and fovea line (DFL) and aligning it between images. We then measured the frequency of remaining PMB at 10 µm intervals along a vertical line intersecting the DFL at its midpoint. Finally, we used a logistic analysis in a much larger group of patients to identify cases of glaucoma with low BCVA (<20/20).Results: In the averaged en-face image, the residual PMB area appeared as a high-intensity region above the DFL. Analysis showed that residual PMB was most common in an area 830-870 µm above the DFL. The correlation coefficient of residual PMB in this area to BCVA was -0.57 (p < .01), and among OCT parameters in this residual PMB area, the AUC to identify decreased BCVA was highest for ganglion cell complex thickness (0.85, p < .01), with a cutoff of 87.5 µm.Conclusions: This study identified specific areas of the PMB that were associated with BCVA in wide-scan, en-face OCT images from glaucoma patients. This suggests that it may be possible to identify visual impairment during glaucoma treatment by measuring this area.
酸化ストレスパラメーターの異常値設定と緑内障患者の割合

前川重人, 檜森紀子, 面高宗子, 中澤徹

日本眼科学会雑誌　125　(臨増)　176-176　2021/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Hierarchical deep learning models using transfer learning for disease detection and classification based on small number of medical images. International-journal

Guangzhou An, Masahiro Akiba, Kazuko Omodaka, Toru Nakazawa, Hideo Yokota

Scientific reports　11　(1)　4250-4250　2021/03/01

DOI： 10.1038/s41598-021-83503-7 　

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Deep learning is being employed in disease detection and classification based on medical images for clinical decision making. It typically requires large amounts of labelled data; however, the sample size of such medical image datasets is generally small. This study proposes a novel training framework for building deep learning models of disease detection and classification with small datasets. Our approach is based on a hierarchical classification method where the healthy/disease information from the first model is effectively utilized to build subsequent models for classifying the disease into its sub-types via a transfer learning method. To improve accuracy, multiple input datasets were used, and a stacking ensembled method was employed for final classification. To demonstrate the method's performance, a labelled dataset extracted from volumetric ophthalmic optical coherence tomography data for 156 healthy and 798 glaucoma eyes was used, in which glaucoma eyes were further labelled into four sub-types. The average weighted accuracy and Cohen's kappa for three randomized test datasets were 0.839 and 0.809, respectively. Our approach outperformed the flat classification method by 9.7% using smaller training datasets. The results suggest that the framework can perform accurate classification with a small number of medical images.
Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc appearances: The Glaucoma Stereo Analysis Study. International-journal

Kazunobu Sugihara, Yasuyuki Takai, Ryo Kawasaki, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Tomoko Naito, Takehiro Yamashita, Shiro Mizoue, Aiko Iwase, Toru Nakazawa, Masaki Tanito

PloS one　16　(7)　e0250245　2021

DOI： 10.1371/journal.pone.0250245 　

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The Glaucoma Stereo Analysis Study (GSAS) is a multicenter collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. This study evaluated the retinal vessel calibers and correlations using GSAS fundus photographs between retinal vessels and 38 optic nerve head (ONH) morphologic parameters comprehensively. In all 240 eyes, the mean central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were 138.4 and 216.5 μm, respectively; the CRAE correlated with age, visual field scores and 19 ONH parameters and CRVE correlated with age, intraocular pressure, visual field scores and 11 ONH parameters. Among the different optic disc appearances including focal ischemia (FI) (n = 53, 22%), generalized enlargement (GE) (n = 53, 22%), myopic glaucoma (MY) (n = 112, 47%), and senile sclerosis (SS) (n = 22, 9%), the CRAE did not differ significantly; CRVE was significantly narrower in SS than in FI and MY. In FI, GE, MY, and SS disc types, CRAE correlated with 3, 14, 9, and 2 ONH parameters, respectively, and CRVE corelated with 9, 0, 12, and 6 ONH parameters, respectively. We confirmed previous observations on the effect of retinal vessel narrowing on glaucomatous changes in the ONH and visual field. The associations between retinal vessel caliber and ONH morphologic parameters vary among different optic disc appearances, suggesting different effects of vascular changes in each disc type.
The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma. International-journal

Noriko Himori, Maki Inoue Yanagimachi, Kazuko Omodaka, Yukihiro Shiga, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　15　2293-2300　2021

DOI： 10.2147/OPTH.S314288 　

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Purpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma. Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett's test. Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated. Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
Evaluation of Papillomacular Nerve Fiber Bundle Thickness in Glaucoma Patients with Visual Acuity Disturbance

N. Takahashi, K. Omodaka, K. Pak, T. Kikawa, W. Kobayashi, M. Akiba, T. Nakazawa

Current Eye Research　45　(7)　847-853　2020/07/02
Publisher: Taylor and Francis Ltd
DOI： 10.1080/02713683.2019.1703006 　

ISSN： 1460-2202 0271-3683
Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography. International-journal Peer-reviewed

Maiko Abe, Kazuko Omodaka, Tsutomu Kikawa, Toru Nakazawa

BMC ophthalmology　20　(1)　199-199　2020/05/24

DOI： 10.1186/s12886-020-01453-6 　

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BACKGROUND: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). METHODS: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch's t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). RESULTS: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o'clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p = 0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). CONCLUSIONS: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.
Progression in Open-Angle Glaucoma with Myopic Disc and Blood Flow in the Optic Nerve Head and Peripapillary Chorioretinal Atrophy Zone

Naoki Kiyota, Yukihiro Shiga, Nana Takahashi, Masayuki Yasuda, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Ophthalmology Glaucoma　3　(3)　202-209　2020/05/01
Publisher: American Academy of Ophthalmology
DOI： 10.1016/j.ogla.2020.03.005 　

ISSN： 2589-4196 2589-4234
Structural Characterization of Glaucoma Patients with Low Ocular Blood Flow. International-journal Peer-reviewed

Kazuko Omodaka, Shunsuke Fujioka, Guangzhou An, Takuma Udagawa, Satoru Tsuda, Yukihiro Shiga, Soichiro Morishita, Tsutomu Kikawa, Kyongsun Pak, Masahiro Akiba, Hideo Yokota, Toru Nakazawa

Current eye research　45　(10)　1-7　2020/03/12

DOI： 10.1080/02713683.2020.1736306 　

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Purpose: There is an unclear relationship between ocular blood flow (OBF) and the structural characteristics of the optic nerve head (ONH) in glaucoma, a multifactorial disease. This study used laser speckle flowgraphy (LSFG) to identify low-OBF glaucoma patients and investigated the ONH in these patients.Materials and Methods: In 533 eyes with glaucoma, we determined confounding factors for LSFG-measured OBF (tissue-area mean blur rate: MT) and corrected MT with a linear mixed-effects model (LMM). Structural ONH data (from fundus stereo photography), OCT data, and clinical characteristics were then compared in patients with corrected MT in the upper and lower quartiles using the LMM.Results: Single regression showed significant correlations between MT and age, spherical equivalent (SE), central corneal thickness (CCT), and a weighted count of retinal ganglion cells (wRGC), but not axial length or systemic blood pressure. Gender also significantly influenced MT; MT was corrected for these correlated factors and also glaucoma type with the LMM. The lower-quartile MT group had a significantly larger cup area and cup-disc area ratio and lower temporal quadrant circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular ganglion cell complex (GCC) than the upper-quartile group.Conclusions: Low-OBF glaucoma patients were characterized by a larger cup-disc ratio, and higher susceptibility to damage in the temporal disc and the macular area.
A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury. International-journal Peer-reviewed

Kota Sato, Seiya Mochida, Daisuke Tomimoto, Takahiro Konuma, Naoki Kiyota, Satoru Tsuda, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Experimental eye research　193　107997-107997　2020/03/09

DOI： 10.1016/j.exer.2020.107997 　

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We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR injury was induced by applying 150 mmHg of intraocular pressure for 50 min. Nov3r was orally administered (100 mg/kg) 3 h before and 24 h after IR injury. TUNEL-positive cells increased and immunoreactive RBPMS-positive cells decreased in the rat retinas after IR injury. Administration of Nov3r significantly ameliorated the increase in TUNEL-positive cells and prevented the RBPMS-positive cell decrease. Similarly, the number of IR-induced Iba1-positive microglial cells was significantly reduced with Nov3r treatment. Among metabolic parameters, IR damage induced the elevation of lactate and pyruvate, and the reduction of ATP. Oral administration of Nov3r ameliorated these changes. Our data suggest that the Nov3r had a retinal neuroprotective effect in IR injury in rats. This finding suggests that the regulation of pyruvate dehydrogenase (PDH) activity has potential therapeutic value by enabling metabolic reprograming in diseases associated with ischemic retinal damage, such as diabetic retinopathy, retinopathy of prematurity, retinal vein occlusion, ischemic optic neuropathy and glaucoma.
The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open-angle glaucoma, a pilot study. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Kyongsun Pak, Hiroshi Kunikata, Toru Nakazawa

Acta ophthalmologica　98　(6)　e747-e753　2020/02/11

DOI： 10.1111/aos.14361 　

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PURPOSE: To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression. METHODS: This prospective, longitudinal study comprised 28 eyes of 16 patients with open-angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue-area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT-change). Follow-up data were collected for at least 2 years, including at least 5 reliable visual field tests. The average total deviation (TD) was calculated in each sector of the Garway-Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT-change, respectively. MT and MT-change in three sectors per eye were included as explanatory variables in a multivariable linear mixed-effects model, with TD slope set as the response variable. RESULTS: At baseline, lower MT and higher diastolic blood pressure were associated with lower MT-change (p < 0.05). Additionally, MT-change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). CONCLUSIONS: Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid visual field defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.
The Sustained Release of Tafluprost with a Drug Delivery System Prevents the Axonal Injury-induced Loss of Retinal Ganglion Cells in Rats. International-journal Peer-reviewed

Kota Sato, Yurika Nakagawa, Kazuko Omodaka, Hiroyuki Asada, Shinobu Fujii, Kenji Masaki, Toru Nakazawa

Current eye research　1-10　2020/01/29

DOI： 10.1080/02713683.2020.1715446 　

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Purpose: To investigated whether a new drug delivery system (DDS) could enable the controlled release of tafluprost and suppress retinal ganglion cell (RGC) death in rats after optic nerve transection (ONT).Methods: A DDS containing 0.04%, 0.20% or 1.00% tafluprost, or vehicle, was injected intravitreally in 8-12-week-old male Sprague-Dawley rats 7 days before ONT, and the retinas were extracted 7 days after ONT. For comparison, eye drops containing 0.0015% tafluprost or vehicle were used once a day. The extracted retinas were analyzed with liquid chromatography-tandem mass spectrometry, immunohistochemistry and western blotting.Results: The level of tafluprost acid in the groups that received the 0.20% and 1.00% tafluprost DDSs was stable, and higher than the maximum concentration in the eye drop group, even after 14 days. In the retinas treated with the 1.00% tafluprost DDS, the active form of the drug had a high concentration (~50 times higher than eye drops), but no significant IOP difference compared with its vehicle in this study. The 1.00% tafluprost DDS group also had less cleaved α-fodrin and fewer c-Jun-positive cells than the vehicle DDS group.Conclusions: This study found that a newly developed DDS allowed the controlled release of tafluprost and prevented the loss of RGCs after ONT IOP independently. The duration of drug action on the target site was longer with a tafluprost DDS than with topical instillation and should therefore reduce problems related to lack of patient compliance. This system may also enable new treatments to prevent RGC degeneration in diseases such as glaucoma.
The association between oxidative stress and corneal hysteresis in patients with glaucoma. International-journal Peer-reviewed

Uchida K, Himori N, Hashimoto K, Shiga Y, Tsuda S, Omodaka K, Nakazawa T

Scientific reports　10　(1)　545-545　2020/01

DOI： 10.1038/s41598-020-57520-x 　

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Systemic antioxidative status has been implicated in glaucoma pathogenesis. Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. Here, we evaluated the relationship between biological antioxidant potential (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We used a free radical analyzer to measure BAP, and an ocular response analyzer to measure CH and corneal resistance factor (CRF). We evaluated the relationship between systemic oxidative stress and other clinical parameters with Spearman's rank correlation test and a multi-regression analysis. BAP was not correlated to either CH or CRF in the male or female OAG patients. BAP was correlated to both CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 years. Multiple regression analysis revealed that BAP independently contributed to CH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic oxidative stress may significantly affect the viscoelasticity of the cornea in older female OAG patients. Future studies are needed to confirm that low systemic antioxidative status and low corneal hysteresis contribute to glaucoma pathogenesis.
The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery. International-journal Peer-reviewed

Kotaro Yamamoto, Taiki Kokubun, Kota Sato, Takahiro Akaishi, Atsushi Shimazaki, Masatsugu Nakamura, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Hideyuki Saya, Toru Nakazawa

Scientific reports　9　(1)　19288-19288　2019/12/17

DOI： 10.1038/s41598-019-55365-7 　

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Treatments for refractory glaucoma include trabeculectomy, in which a filtering bleb is created to reduce aqueous pressure. Mitomycin C (MMC) is often used as an adjuvant to reduce post-trabeculectomy bleb scarring and consequent failure. However, scarring sometimes still occurs. Thus, we searched for more effective trabeculectomy adjuvants with high-throughput screening (HTS) of a library of 1,165 off-patent drug compounds. This revealed that amsacrine (AMSA), a DNA topoisomerase II (TOP2) inhibitor, was the top candidate. Compared to MMC, rabbits that underwent trabeculectomy with 10% AMSA had lower IOP at 42, 56, and 70 days (P < 0.01 at all measurement points) and a higher bleb score at 28, 42, 56, and 70 days (P = < 0.01, 0.04, 0.04, and < 0.01, respectively). Compared to saline, rabbits that received 1% AMSA also had lower IOP and better bleb score at all time points, without a sharp drop in IOP just after surgery (all P < 0.01). Both effects were milder than MMC at 7 days (P = 0.02 and <0.01, respectively). Thus, this study showed that HTS may help identify new, promising uses for off-patent drugs. Furthermore, trabeculectomy with AMSA at a suitable concentration may improve the prognosis after trabeculectomy compared to MMC.
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. International-journal Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Kazuko Omodaka, Benjamin Thyreau, Izumi Matsudaira, Hiroaki Furukawa, Keiji Yamada, Keiko Kunitoki, Ryuta Kawashima, Toru Nakazawa, Yasuyuki Taki

Scientific reports　9　(1)　15148-15148　2019/10/22

DOI： 10.1038/s41598-019-51611-0 　

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Elongated axial length of the eye increases the morbidity of glaucoma. Myopia also associates with elongated axial length, and such ellipsoid shape of the eyeball strongly contributes its pathogenesis. Morphological features of the eyeballs, which could be important factors for developing glaucoma, have not been well described. The aim of this study was to investigate the three-dimensional (3D) topographic features of glaucomatous eyeballs with/without myopia to evaluate the potential of those features for predicting glaucoma. Using a 3.0-tesla MRI, volume-isotropic turbo-spin-echo acquisition T2-weighted images were obtained from 55 patients with glaucoma and 22 controls to delineate the eyeballs. Eyeball volumes, axial lengths and transverse lengths were semi-automatically calculated and compared between four groups: normal, myopia, glaucoma, and glaucoma with myopia. Both glaucoma and myopia increased the eyeball volume compared to the normal eyes. An increased anisotropy ratio (axial/transversus length) was observed in myopic eyes compared to normal, whereas in the glaucomatous eyes, with or without myopia, no increase in anisotropy ratio was observed. Increasing volume of eyes can be caused by myopia and glaucoma. Myopic eyes were ellipsoid in shape, but there was less anisotropy and a near-spherical shape in glaucomatous eyes, even in glaucomatous myopic eyes.
緑内障性視野障害の評価における深層学習の有用性の検討

二宮高洋, 面高宗子, 橋本和軌, 高田菜生子, 中澤徹

日本緑内障学会抄録集　30回　143-143　2019/09
Publisher: 日本緑内障学会
Retinal Thickness Analysis in High Myopia based on Medial Axis Transforms. International-journal Peer-reviewed

Takashi Michikawa, Satoshi Wada, Hideo Yokota, Guangzhou An, Masahiro Akiba, Kazuko Omodaka, Toru Nakazawa

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2019　2805-2808　2019/07

DOI： 10.1109/EMBC.2019.8857091 　

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This paper presents a retinal thickness analysis method from 3D images acquired by optical coherence tomography (OCT). Given OCT images with segmented boundaries of retinal layers, medial axes of the layers are computed by medial axis transforms (MAT), and thickness is evaluated based on Euclidean distance fields. Since the MAT computes the closest points on the boundary of the layer, it can compute more correct thickness than conventional methods that evaluate Y-axis-aligned thickness. Experimental results show that our method can detect thin-parts around distorted regions, or a clue of high myopia. This is useful for early diagnosis of high myopia and other eye diseases.
Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Investigative ophthalmology & visual science　60　(7)　2650-2658　2019/06/03

DOI： 10.1167/iovs.19-27230 　

ISSN： 0146-0404

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Purpose: To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding visual field defect severity, and future progression. Methods: This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: -9.2 ± 7.0 dB), followed for an average of 4.7 ± 1.1 years; an average 11.7 ± 3.7 visual field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. Results: At baseline, the highest β coefficients were found between MT-superior and TD-inferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (β = 0.38, β = 0.27, β = 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). Conclusions: Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict visual field defect severity and progression.
Effects of Brimonidine and Timolol on the Progression of Visual Field Defects in Open-angle Glaucoma: A Single-center Randomized Trial. International-journal Peer-reviewed

Yokoyama Y, Kawasaki R, Takahashi H, Maekawa S, Tsuda S, Omodaka K, Nakazawa T

Journal of glaucoma　28　(7)　575-583　2019/06

DOI： 10.1097/IJG.0000000000001285 　

ISSN： 1057-0829

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PRéCIS:: Instillation of brimonidine or timolol slowed visual field deterioration in patients with open-angle glaucoma; both brimonidine and timolol might improve the mean deviation (MD) slopes. PURPOSE: The purpose of this study was to investigate and compare the effects of 0.1% brimonidine and 0.5% timolol on the progressing visual field defects in open-angle glaucoma. PATIENTS AND METHODS: We evaluated 1 eye each of 68 glaucoma patients who were treated with at least 1 prostaglandin analog. Their baseline MD slopes were < -0.5 dB/y based on at least 5 Humphrey field analyzer measurements within 3 years. Eligible eyes were randomly assigned to brimonidine or timolol treatment groups and treatments were administered without the wash-out period. Clinical examinations were performed every 4 months for 2 years. We designated the MD slope as the primary endpoint. RESULTS: Ultimately, 56 eyes (brimonidine:timolol=26:30) were included in the present study (mean age=65.2 y). Dropout rates of brimonidine and timolol treatment groups were 27.8% and 6.3%, respectively. There were no significant differences in baseline intraocular pressure or MD slopes between brimonidine and timolol groups (12.7 and 12.9 mm Hg, P=0.77, and -1.22 and -1.08 dB/y, P=0.43, respectively). Intraocular pressure decreased significantly in the brimonidine group at 4, 8, 12, and 16 months, and in the timolol group at 4 months, without significant differences between the drugs (P=0.20). MD slopes significantly improved in both groups (brimonidine: -0.38 dB/y, P<0.001; timolol: -0.52 dB/y, P=0.04). Furthermore, there was no significant difference between groups in the primary endpoint (P=0.59). CONCLUSION: Brimonidine and timolol treatments improved MD slopes in open-angle glaucoma.
Genetic characteristics of retinitis pigmentosa in 1204 Japanese patients. Peer-reviewed

Koyanagi Y, Akiyama M, Nishiguchi KM, Momozawa Y, Kamatani Y, Takata S, Inai C, Iwasaki Y, Kumano M, Murakami Y, Omodaka K, Abe T, Komori S, Gao D, Hirakata T, Kurata K, Hosono K, Ueno S, Hotta Y, Murakami A, Terasaki H, Wada Y, Nakazawa T, Ishibashi T, Ikeda Y, Kubo M, Sonoda KH

Journal of medical genetics　56　(10)　662-670　2019/06
Publisher: BMJ
DOI： 10.1136/jmedgenet-2018-105691 　

ISSN： 0022-2593

eISSN： 1468-6244

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<sec><title>Background</title>The genetic profile of retinitis pigmentosa (RP) in East Asian populations has not been well characterised. Therefore, we conducted a large-scale sequencing study to investigate the genes and variants causing RP in a Japanese population. </sec><sec><title>Methods</title>A total of 1209 Japanese patients diagnosed with typical RP were enrolled. We performed deep resequencing of 83 known causative genes of RP using next-generation sequencing. We defined pathogenic variants as those that were putatively deleterious or registered as pathogenic in the Human Gene Mutation Database or ClinVar database and had a minor allele frequency in any ethnic population of ≤0.5% for recessive genes or ≤0.01% for dominant genes as determined using population-based databases. </sec><sec><title>Results</title>We successfully sequenced 1204 patients with RP and determined 200 pathogenic variants in 38 genes as the cause of RP in 356 patients (29.6%). Variants in six genes (<italic>EYS</italic>, <italic>USH2A</italic>, <italic>RP1L1</italic>, <italic>RHO</italic>, <italic>RP1</italic> and <italic>RPGR</italic>) caused RP in 65.4% (233/356) of those patients. Among autosomal recessive genes, two known founder variants in <italic>EYS</italic> [p.(Ser1653fs) and p.(Tyr2935*)] and four East Asian-specific variants [p.(Gly2752Arg) in <italic>USH2A</italic>, p.(Arg658*) in <italic>RP1L1</italic>, p.(Gly2186Glu) in <italic>EYS</italic> and p.(Ile535Asn) in <italic>PDE6B</italic>] and p.(Cys934Trp) in <italic>USH2A</italic> were found in ≥10 patients. Among autosomal dominant genes, four pathogenic variants [p.(Pro347Leu) in <italic>RHO</italic>, p.(Arg872fs) in <italic>RP1</italic>, p.(Arg41Trp) in <italic>CRX</italic> and p.(Gly381fs) in <italic>PRPF31</italic>] were found in ≥4 patients, while these variants were unreported or extremely rare in both East Asian and non-East Asian population-based databases. </sec><sec><title>Conclusions</title>East Asian-specific variants in causative genes were the major causes of RP in the Japanese population. </sec>
Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Images. International-journal Peer-reviewed

An G, Omodaka K, Hashimoto K, Tsuda S, Shiga Y, Takada N, Kikawa T, Yokota H, Akiba M, Nakazawa T

Journal of healthcare engineering　2019　4061313-4061313　2019

DOI： 10.1155/2019/4061313 　

ISSN： 2040-2295

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This study aimed to develop a machine learning-based algorithm for glaucoma diagnosis in patients with open-angle glaucoma, based on three-dimensional optical coherence tomography (OCT) data and color fundus images. In this study, 208 glaucomatous and 149 healthy eyes were enrolled, and color fundus images and volumetric OCT data from the optic disc and macular area of these eyes were captured with a spectral-domain OCT (3D OCT-2000, Topcon). Thickness and deviation maps were created with a segmentation algorithm. Transfer learning of convolutional neural network (CNN) was used with the following types of input images: (1) fundus image of optic disc in grayscale format, (2) disc retinal nerve fiber layer (RNFL) thickness map, (3) macular ganglion cell complex (GCC) thickness map, (4) disc RNFL deviation map, and (5) macular GCC deviation map. Data augmentation and dropout were performed to train the CNN. For combining the results from each CNN model, a random forest (RF) was trained to classify the disc fundus images of healthy and glaucomatous eyes using feature vector representation of each input image, removing the second fully connected layer. The area under receiver operating characteristic curve (AUC) of a 10-fold cross validation (CV) was used to evaluate the models. The 10-fold CV AUCs of the CNNs were 0.940 for color fundus images, 0.942 for RNFL thickness maps, 0.944 for macular GCC thickness maps, 0.949 for disc RNFL deviation maps, and 0.952 for macular GCC deviation maps. The RF combining the five separate CNN models improved the 10-fold CV AUC to 0.963. Therefore, the machine learning system described here can accurately differentiate between healthy and glaucomatous subjects based on their extracted images from OCT data and color fundus images. This system should help to improve the diagnostic accuracy in glaucoma.
Color visual acuity in preperimetric glaucoma and open-angle glaucoma. International-journal Peer-reviewed

Junko Ouchi, Hiroshi Kunikata, Kazuko Omodaka, Haruka Sato, Hiroyuki Sato, Azusa Ito, Naoko Aizawa, Yoshiki Tanaka, Kazuo Ichikawa, Toru Nakazawa

PloS one　14　(4)　e0215290　2019

DOI： 10.1371/journal.pone.0215290 　

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PURPOSE: To investigate the clinical significance of color visual acuity (CVA) in preperimetric glaucoma (PPG) and open-angle glaucoma (OAG). METHODS: A total of 123 eyes of 73 subjects (22 normal eyes, 14 PPG eyes, and 87 OAG eyes; mean age: 44.9 ± 10.1 years, age range: 21-64 years) were enrolled. CVA was tested for red, green-yellow, blue-green and blue-purple with a newly developed test. RESULTS: There was no statistical difference in clinical background factors, including age, sex, intraocular pressure, or spherical equivalent between the three groups. Red VA and blue-green VA were significantly worse in the OAG eyes than in the normal eyes (P = 0.008 and P = 0.015, respectively), although green-yellow VA and blue-purple VA were not significantly worse. Furthermore, red VA and blue-green VA were significantly correlated with MD in a group of eyes with either PPG or OAG (r = -0.23, P = 0.023; r = -0.25, P = 0.012, respectively), but green-yellow VA and blue-purple VA were not. CONCLUSION: Red VA and blue-green VA were detectably worse in eyes with OAG, in close association with the degree of functional loss. This suggests that measuring CVA with the new color test described here may be a promising supplement to existing methods of detecting glaucoma and evaluating its severity.
The relationship between glutathione levels in leukocytes and ocular clinical parameters in glaucoma. International-journal Peer-reviewed

Takeshi Yabana, Kota Sato, Yukihiro Shiga, Noriko Himori, Kazuko Omodaka, Toru Nakazawa

PloS one　14　(12)　e0227078　2019

DOI： 10.1371/journal.pone.0227078 　

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PURPOSE: To investigate the effect of mitochondrial dysfunction on the autoregulation of blood flow, by measuring levels of glutathione, an indicator of mitochondrial dysfunction, in glaucoma patients. METHODS: Fifty-six OAG patients and 21 age-matched controls underwent a blood assay. Mitochondrial function was measured according to the levels of total glutathione (t-GSH), reduced GSH (GSH), and oxidized GSH (GSSG, glutathione disulfide) in peripheral blood mononuclear cells. Ocular blood flow in the optic nerve head was assessed with laser speckle flowgraphy parameters, including acceleration time index (ATI). We determined correlations between these measurements and other clinical parameters. Furthermore, we investigated the association between glutathione levels and glaucoma with a logistic regression analysis. Finally, we calculated the area under the receiver operating characteristic (ROC) curve in order to determine the power of redox index (the log GSH/GSSG ratio) to distinguish the groups. RESULTS: OAG patients demonstrated significantly higher GSSG levels and a lower redox index than the controls (p = 0.01, p = 0.01, respectively), but total GSH and reduced GSH levels were similar in the OAG subjects and controls (p = 0.80, p = 0.94, respectively). Additionally, redox index was significantly correlated with mean deviation (MD) of the visual field (r = 0.29, p = 0.03) and ATI (r = -0.30, p = 0.03). Multiple linear regression analysis showed that redox index contributed to MD (p = 0.02) and ATI (p = 0.04). The receiver operating characteristic curve (AUC) analysis suggested that redox index could differentiate between control eyes and eyes with glaucoma (AUC; 0.70: 95% interval; 0.57-0.84). The cutoff point for redox index to maximize its sensitivity and specificity was 2.0 (sensitivity: 91.1%, specificity: 42.9%). CONCLUSIONS: These results suggest that redox index is lower in OAG patients than in controls. Thus, it is possible that mitochondrial dysfunction contributes to glaucoma pathogenesis by causing vascular alterations.
The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits. International-journal Peer-reviewed

Kokubun T, Yamamoto K, Sato K, Akaishi T, Shimazaki A, Nakamura M, Shiga Y, Tsuda S, Omodaka K, Nakazawa T

PloS one　14　(3)　e0213811　2019

DOI： 10.1371/journal.pone.0213811 　

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PURPOSE: To investigate the potential of colchicine to improve bleb function after trabeculectomy. METHODS: To find the maximum usable colchicine concentration, an ocular irritation study was performed with the Draize test at concentrations of 0.001%, 0.01% and 0.1%. Additionally, the synergistic effect of topical colchicine instillation and MMC application to surgical site was evaluated in a rabbit model by measuring changes after trabeculectomy in intraocular pressure (IOP) and bleb morphology score at 3, 7, 14, 21, 28, 35, 42, and 49 days. RESULTS: Experiments with a rabbit model of trabeculectomy showed that 0.04% MMC plus 0.01% colchicine was more effective than saline and 0.04% MMC alone in maintaining IOP reduction at days 7-49 (P < 0.01 at all time points) and day 49 (P < 0.05), respectively, while 0.04% MMC alone was more effective than saline only at days 7-35 (P < 0.05 at all time points). 0.04% MMC plus 0.01% colchicine and 0.04% MMC alone were more effective than saline at preserving bleb score at days 7-21 and 35-49 (P < 0.05 at all time points) and at days 7-35 (P < 0.05 at all time points), respectively. CONCLUSION: Colchicine may be a promising adjuvant for strengthening the effect of MMC and improving the survival of the filtering bleb in trabeculectomy.
Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma With Anterior-segment Optical Coherence Tomography. International-journal Peer-reviewed

Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Noriko Himori, Yu Yokoyama, Kazuko Omodaka, Shiho Kunimatsu-Sanuki, Toru Nakazawa

Journal of glaucoma　27　(12)　1157-1164　2018/12

DOI： 10.1097/IJG.0000000000001081 　

ISSN： 1057-0829

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PURPOSE: To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict posttrabeculectomy outcomes in neovascular glaucoma (NVG). PATIENTS AND METHODS: We recruited 45 eyes of 40 NVG patients who underwent trabeculectomy. The patients were divided into success and failure groups based on the posttrabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed early posttrabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operating characteristic curve to evaluate the power of these parameters to predict long-term outcomes. RESULTS: Intraocular pressure at 6 and 12 months was lower in the success group than the failure group (P<0.0016=0.0048). Reflectivity of the bleb wall was higher in the failure group than the success group throughout the study (all: P<0.0016). Age and reflectivity of the bleb wall at 1 week were risk factors for failure with odds ratios for failure of 0.91 and 1.67. The area under the receiver operating characteristic curve for reflectivity of the bleb wall at 1 week was 0.943 with the cutoff set at 128.9 (sensitivity: 85.7%; specificity: 100.0%). Stepwise multiple regression analysis showed that reflectivity of the bleb wall at 1 week independently indicated the bleb survival period (β=-0.84; P<0.001). CONCLUSIONS: AS-OCT-measured reflectivity of the bleb wall, measured at 1 week of trabeculectomy for NVG, might be able to predict of the final status of the bleb.
Metabolomic changes in the mouse retina after optic nerve injury. International-journal Peer-reviewed

Kota Sato, Daisuke Saigusa, Ritsumi Saito, Amane Fujioka, Yurika Nakagawa, Koji M Nishiguchi, Taiki Kokubun, Ikuko N Motoike, Kazuichi Maruyama, Kazuko Omodaka, Yukihiro Shiga, Akira Uruno, Seizo Koshiba, Masayuki Yamamoto, Toru Nakazawa

Scientific reports　8　(1)　11930-11930　2018/08/09

DOI： 10.1038/s41598-018-30464-z 　

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In glaucoma, although axonal injury drives retinal ganglion cell (RGC) death, little is known about the underlying pathomechanisms. To provide new mechanistic insights and identify new biomarkers, we combined latest non-targeting metabolomics analyses to profile altered metabolites in the mouse whole retina 2, 4, and 7 days after optic nerve crush (NC). Ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and liquid chromatography Fourier transform mass spectrometry covering wide spectrum of metabolites in combination highlighted 30 metabolites that changed its concentration after NC. The analysis displayed similar changes for purine nucleotide and glutathione as reported previously in another animal model of axonal injury and detected multiple metabolites that increased after the injury. After studying the specificity of the identified metabolites to RGCs in histological sections using imaging mass spectrometry, two metabolites, i.e., L-acetylcarnitine and phosphatidylcholine were increased not only preceding the peak of RGC death in the whole retina but also at the RGC layer (2.3-fold and 1.2-fold, respectively). These phospholipids propose novel mechanisms of RGC death and may serve as early biomarkers of axonal injury. The combinatory metabolomics analyses promise to illuminate pathomechanisms, reveal biomarkers, and allow the discovery of new therapeutic targets of glaucoma.
Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina. International-journal Peer-reviewed

Sato K, Shiga Y, Nakagawa Y, Fujita K, Nishiguchi KM, Tawarayama H, Murayama N, Maekawa S, Yabana T, Omodaka K, Katayama S, Feng Q, Tsuda S, Nakazawa T

Investigative ophthalmology & visual science　59　(10)　3943-3951　2018/08

DOI： 10.1167/iovs.18-23784 　

ISSN： 0146-0404

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Purpose: To assess the therapeutic potential of endothelin-converting enzyme-like 1 (Ecel1) in a mouse model of optic nerve crush. Methods: Ecel1 expression was evaluated with real time quantitative (qRT)-PCR, Western blotting, and immunohistochemistry in mouse retinas after optic nerve crush. Vinblastine administration to the optic nerve and the intravitreal injection of N-methyl-d-aspartate (NMDA) were used to assess Ecel1 gene expression. Ecel1 was deleted with an adeno-associated viral (AAV) clustered regulatory interspaced short palindromic repeat (CRISPR)/Cas9 system, and retinal ganglion cell (RGC) survival was investigated with retrograde labeling, qRT-PCR, and visual evoked potential. Results: Optic nerve crush induced Ecel1 expression specifically in the RGCs, peaking on day 4 after optic nerve crush. Ecel1 gene expression was induced by the vinblastine-induced inhibition of axonal flow, but not by NMDA-induced excitotoxicity, even though both are triggers of RGC death. Knockdown of Ecel1 promoted the loss of RGCs after optic nerve crush. Conclusions: Our data suggest that Ecel1 induction is part of the retinal neuroprotective response to axonal injury in mice. These findings might provide insight into novel therapeutic targets for the attenuation of RGC damage, such as occurs in traumatic optic neuropathy.
The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow. International-journal Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, Masayuki Yasuda, Naoko Aizawa, Kazuko Omodaka, Naoto Honda, Hiroshi Kunikata, Toru Nakazawa

Investigative ophthalmology & visual science　59　(8)　3488-3496　2018/07/02

DOI： 10.1167/iovs.18-23872 　

ISSN： 0146-0404

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Purpose: To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods: This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20 mm Hg), and a recovery phase. IOP was elevated by pushing against the eyelid with a novel tubular device attached to the LSFG apparatus. Measurement parameters in each phase included: LSFG-derived mean blur rate (MBR) and flow acceleration index (FAI); systemic parameters, and IOP. The % change against baseline was calculated for each phase. The protocol was repeated five times to calculate the coefficient of variation (CV) for % change MBR and to determine the effect of mydriasis on % change MBR. We compared % change MBR and FAI and evaluated the relationship between % change ocular perfusion pressure (OPP) and MBR in the choroid and ONH tissue. Results: The % change MBR was highly reproducible (CV: 6.1-8.7%) and not affected by mydriasis (P = 0.57-0.96). The % change MBR and FAI were higher in the ONH tissue than choroid during IOP elevation (P = 0.04). The % change OPP and MBR showed positive linear correlations and two-segmental linear correlations in the choroid and ONH tissue, respectively (P < 0.01). Conclusion: Hemodynamics during IOP elevation differ in the choroid and ONH tissue. LSFG enables highly reproducible assessment of the dynamic autoregulation of ocular BF in the ONH tissue.
Validation of formula-predicted glaucomatous optic disc appearances: the Glaucoma Stereo Analysis Study. International-journal Peer-reviewed

Tanito M, Nitta K, Katai M, Kitaoka Y, Yokoyama Y, Omodaka K, Naito T, Yamashita T, Mizoue S, Iwase A, Nakazawa T

Acta ophthalmologica　97　(1)　e42-e49　2018/07

DOI： 10.1111/aos.13816 　

ISSN： 1755-375X

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AIMS: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. SUBJECTS AND METHODS: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs. The agreement between grader-classified optic disc types, that is, focal ischemic (FI), generalized enlargement, myopic glaucomatous (MY), and senile sclerotic (SS) and formula-predicted optic disc types, that is, pFI, pGE, pMY and pSS, were assessed. RESULTS: Based on this formula, the eyes were classified with pFI (21 eyes, 22.6%), pGE (27 eyes, 29.0%), pMY (26 eyes, 28.0%) and pSS (19 eyes, 20.4%) when the top predictive element based on the formula was considered as the optic disc appearance in each eye. The six topographic parameters used in the formula differed significantly among the four predicted optic disc types. Substantial agreement (κ = 0.7496) was seen for the top two predictive elements based on the formula that agreed with the graders' classification in 76 (81.7%) eyes. Among the four optic disc types, the levels of agreement were relatively lower in the SS type (κ = 0.3863-0.5729) compared with the other three optic disc types (κ = 0.7898-0.8956) even though the unclassifiable and mixed optic disc types were excluded from the testing dataset. CONCLUSION: The GSAS classification formula can predict and quantify each component of different optic disc appearances in each eye and provide a novel parameter to describe glaucomatous optic disc characteristics.
Predicting the Integrated Visual Field with Wide-Scan Optical Coherence Tomography in Glaucoma Patients Peer-reviewed

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

Current Eye Research　43　(6)　754-761　2018/06/03
Publisher: Taylor and Francis Ltd
DOI： 10.1080/02713683.2018.1439065 　

ISSN： 1460-2202 0271-3683
The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome. International-journal Peer-reviewed

Erika Yamada, Noriko Himori, Hiroshi Kunikata, Kazuko Omodaka, Hiromasa Ogawa, Masakazu Ichinose, Toru Nakazawa

Acta ophthalmologica　96　(4)　e479-e484　2018/06

DOI： 10.1111/aos.13693 　

ISSN： 1755-375X

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PURPOSE: Sleep apnoea syndrome (SAS) is often associated with glaucoma, and intermittent hypoxia, present in SAS, can contribute to glaucoma pathogenesis. However, the relationships between SAS, high systemic oxidative stress and the speed of glaucoma progression are unclear. Thus, we investigated these relationships in glaucoma patients with and without SAS. METHODS: Peripheral blood samples were collected from 166 eyes of 166 Japanese patients: 42 controls, 109 open-angle glaucoma (OAG) patients without SAS and 15 OAG patients with SAS. Prognostic factors for visual field defect progression were determined with logistic regression. Diacron reactive oxygen metabolites (dROM) and biological antioxidant potential (BAP) were measured with a free radical analyser. Clinical parameters were also recorded. Intergroup comparisons used the Mann-Whitney U test. RESULTS: Multiple regression analysis showed that SAS was a statistically significant contributing factor to fast visual field defect progression, defined as mean deviation (MD) slope ≤-2.0 dB/Y (SAS: odds ratio (OR) = 14.48; p = 0.002). The non-SAS and SAS groups had similar age, sex, intraocular pressure (IOP), axial length and antiglaucoma drug use. The SAS group had a significantly higher dROM level (p = 0.001), BAP level (p = 0.038) and steeper MD slope (p = 0.001) than the non-SAS group. CONCLUSION: Glaucoma patients with SAS have higher dROM, as well as steeper MD slope, than patients without SAS, suggesting that SAS may induce systemic oxidative stress and promote glaucomatous visual field defect progression.
Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma. International-journal Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Acta ophthalmologica　96　(4)　e485-e492　2018/06

DOI： 10.1111/aos.13639 　

ISSN： 1755-375X

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PURPOSE: To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA). METHODS: We retrospectively studied 82 eyes of 82 open-angle glaucoma (OAG) patients who underwent same-day LSFG and OCTA examinations, with 20 eyes of 20 healthy subjects as controls. In OCTA images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1.6-, 3.2- and 3.6-mm-diameter circles around the optic nerve head (ONH). In R3, the large vessels were automatically masked to calculate pure capillary density (auto R3 VD). LSFG-measured mean blur rate (MBR) was examined in the overall ONH (MA), vessel-area ONH (MV) and tissue-area ONH (MT). RESULTS: Auto R3 VD had high reproducibility (coefficient of variation: 1.65-3.88%) and accurately reflected manual R3 VD [mean bias: -0.0087% (auto R3 VD - manual R3 VD)]. MA and MT decreased significantly with OAG severity, especially in the early OAG stages (control vs. mild: p = 0.003 and p < 0.001, respectively). R1 VD did not change with severity. R2 and auto R3 VD decreased significantly with OAG severity, especially in the severe stages (R2, mild vs. severe: p = 0.008; auto R3 VD, mild vs. severe: p < 0.001, moderate vs. severe: p = 0.028). CONCLUSION: Optical coherence tomography angiography-derived auto R3 VD is novel, reproducible and accurately reflects manual measurements. It is useful for differentiating moderate and advanced glaucoma, while LSFG-derived MT is useful for identifying early glaucoma.
Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc. International-journal Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

Acta ophthalmologica　96　(3)　e290-e297-e297　2018/05

DOI： 10.1111/aos.13621 　

ISSN： 1755-375X

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PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software. Clinical characteristics, laser speckle flowgraphy-measured mean blur rate in the temporal tissue area (temporal MT), the central thresholds (the averaged standard automated perimetry-measured visual field thresholds in the four paracentral points) and 3D-OCT-measured ganglion cell complex thickness in the papillomacular bundle (PMB-GCCT) were recorded. RESULTS: The NTG patients had significantly lower intraocular pressure, PMB-GCCT and central threshold values, and a larger PPA area, than the controls. The area under the receiver operating characteristics curve to differentiate NTG with parafoveal scotoma (PFS) from controls was 0.76 for temporal MT, 0.85 for PPA-CI and 0.87 for PMB-GCCT. Univariate and multivariate analyses revealed that PPA-CI was negatively correlated with age, pulse rate, best-corrected visual acuity, axial length and PPA area, and positively correlated with temporal MT, PMB-GCCT and the central thresholds. CONCLUSION: Peripapillary chorioretinal atrophy (PPA)-CI was associated with temporal MT, ageing, bradycardia, axial length elongation and changes in central retinal structure and visual function in patients with NTG and myopic disc. Thus, microcirculation deep within the PPA zone might be a clinically useful biomarker of PFS in NTG.
Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography. International-journal Peer-reviewed

Omodaka K, Maekawa S, An G, Tsuda S, Shiga Y, Takada N, Kikawa T, Takahashi H, Yokota H, Akiba M, Nakazawa T

PloS one　13　(11)　e0207600　2018

DOI： 10.1371/journal.pone.0207600 　

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PURPOSE: To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma. METHODS: This retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2.6-micron intervals) with VCAT5 (RIKEN, Japan). We compared the control and OAG subjects with the Mann-Whitney U test. Differences were considered significant at p < 0.05. RESULTS: We found that the laminar pores of the OAG patients had a significantly smaller average cross-sectional area, smaller 3D volume (adjusted to the average thickness of the lamina cribrosa), and higher true sphericity, and lower principal value (P1, 2, 3) of the 3D structure data (all: p < 0.0001). The topographic distribution of damaged laminar pores was consistent with the damaged area of the macular map. CONCLUSION: We successfully developed a method to quantify the 3D structure of the laminar pores; providing a useful tool to assess lamina cribrosa-associated risk factors for glaucoma. These findings promise to benefit future investigations into the pathomechanisms of glaucoma.
Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes. International-journal Peer-reviewed

Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Hiroshi Kunikata, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa

Translational vision science & technology　7　(1)　11-11　2018/01

DOI： 10.1167/tvst.7.1.11 　

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Purpose: To investigate the site specificity of visual field changes in eyes with normotensive preperimetric glaucoma (PPG), and to determine factors influencing visual field progression. Methods: This prospective study comprised 84 eyes of 84 normotensive PPG patients followed for at least 16 months. Optic nerve head (ONH) blood flow was assessed with tissue-area mean blur rate (MBRT), derived from laser speckle flowgraphy. Total deviation (TD) was measured in each sector of the Garway-Heath map to evaluate the site specificity of visual field loss. Subjects with a TD slope in the first quartile were classified as progressive, and other subjects as nonprogressive. Linear and multiple regression analyses were performed to determine factors affecting visual field progression. Results: TD in the superior sector significantly decreased in the subjects overall during the follow-up periods (-0.48 ± 1.92 dB/y, P = 0.025). Linear regression analysis showed that basal MBRT-inferior was correlated significantly with TD-superior slope (r = 0.332, P = 0.002). Furthermore, basal MBRT was significantly lower in this sector in the progressive than the nonprogressive group (P = 0.010). Multiple linear regression analysis revealed that basal MBRT-inferior was the only predictive factor for TD-superior slope (β = 0.329, P = 0.005). Conclusions: These findings suggest that superior-sector visual field progression is most common in normotensive PPG eyes, and that reduced basal ONH blood flow is associated with visual field progression. Translational Relevance: These findings provide new insight into the involvement of ONH blood flow impairment in glaucoma pathogenesis, and demonstrate the importance of assessing ONH blood flow to determine visual field progression in normotensive PPG.
A Small Disc Area Is a Risk Factor for Visual Field Loss Progression in Primary Open-Angle Glaucoma: The Glaucoma Stereo Analysis Study. International-journal Peer-reviewed

Kitaoka Y, Tanito M, Yokoyama Y, Nitta K, Katai M, Omodaka K, Nakazawa T

Journal of ophthalmology　2018　8941489-8941489　2018

DOI： 10.1155/2018/8941489 　

ISSN： 2090-004X

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Purpose: The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods: The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patients into the progression group (<-0.3 dB/year) and no-progression group (≧-0.3 dB/year). ONH morphological parameters were calculated with prototype analysis software. The correlations between glaucomatous visual field progression and patient characteristics or each ONH parameter were analyzed with Spearman's rank correlation coefficient. Results: The MD slope averages in the progression group and no-progression group were -0.58 ± 0.28 dB/year and 0.05 ± 0.26 dB/year, respectively. Among disc parameters, vertical disc width (diameter), disc area, cup area, and cup volume in the progression group were significantly less than those in the no-progression group. Logistic regression analysis revealed a significant association between the visual field progression and disc area (odds ratio 0.49/mm2 disc area). Conclusion: A smaller disc area may be associated with more rapid glaucomatous visual field progression.
Quantitative MRI evaluation of glaucomatous changes in the visual pathway. International-journal Peer-reviewed

Fukuda M, Omodaka K, Tatewaki Y, Himori N, Matsudaira I, Nishiguchi KM, Murata T, Taki Y, Nakazawa T

PloS one　13　(7)　e0197027　2018

DOI： 10.1371/journal.pone.0197027 　

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BACKGROUND: The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG). METHODS: Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman's rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19. RESULTS: We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099). CONCLUSION: Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG.
Comparison of Machine-Learning Classification Models for Glaucoma Management. International-journal Peer-reviewed

An G, Omodaka K, Tsuda S, Shiga Y, Takada N, Kikawa T, Nakazawa T, Yokota H, Akiba M

Journal of healthcare engineering　2018　6874765-6874765　2018

DOI： 10.1155/2018/6874765 　

ISSN： 2040-2295

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This study develops an objective machine-learning classification model for classifying glaucomatous optic discs and reveals the classificatory criteria to assist in clinical glaucoma management. In this study, 163 glaucoma eyes were labelled with four optic disc types by three glaucoma specialists and then randomly separated into training and test data. All the images of these eyes were captured using optical coherence tomography and laser speckle flowgraphy to quantify the ocular structure and blood-flow-related parameters. A total of 91 parameters were extracted from each eye along with the patients' background information. Machine-learning classifiers, including the neural network (NN), naïve Bayes (NB), support vector machine (SVM), and gradient boosted decision trees (GBDT), were trained to build the classification models, and a hybrid feature selection method that combines minimum redundancy maximum relevance and genetic-algorithm-based feature selection was applied to find the most valid and relevant features for NN, NB, and SVM. A comparison of the performance of the three machine-learning classification models showed that the NN had the best classification performance with a validated accuracy of 87.8% using only nine ocular parameters. These selected quantified parameters enabled the trained NN to classify glaucomatous optic discs with relatively high performance without requiring color fundus images.
The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation Peer-reviewed

Shigeto Maekawa, Kota Sato, Kosuke Fujita, Reiko Daigaku, Hiroshi Tawarayama, Namie Murayama, Satoru Moritoh, Takeshi Yabana, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa

Scientific Reports　7　(1)　6885　2017/12/01
Publisher: Nature Publishing Group
DOI： 10.1038/s41598-017-06969-4 　

ISSN： 2045-2322
Preperimetric Glaucoma Prospective Observational Study (PPGPS): Design, baseline characteristics, and therapeutic effect of tafluprost in preperimetric glaucoma eye Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Hiroaki Kurashima, Etsuyo Miyamoto, Masayo Hashimoto, Toru Nakazawa

PLOS ONE　12　(12)　e0188692　2017/12

DOI： 10.1371/journal.pone.0188692 　

ISSN： 1932-6203
Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7 Peer-reviewed

Yukihiro Shiga, Japan Glaucoma Society Omics Group (JGS-OG), Koji M. Nishiguchi, Yosuke Kawai, Kaname Kojima, Kota Sato, Kosuke Fujita, Mai Takahashi, Kazuko Omodaka, Makoto Araie, Kenji Kashiwagi, Makoto Aihara, Takeshi Iwata, Fumihiko Mabuchi, Mitsuko Takamoto, Mineo Ozaki, Kazuhide Kawase, Nobuo Fuse, Masayuki Yamamoto, Jun Yasuda, Masao Nagasaki, Toru Nakazawa

PLoS ONE　12　(12)　e0186678　2017/12/01
Publisher: Public Library of Science
DOI： 10.1371/journal.pone.0186678 　

ISSN： 1932-6203
Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters Peer-reviewed

Kazuko Omodaka, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa

PLOS ONE　12　(12)　e0190012　2017/12

DOI： 10.1371/journal.pone.0190012 　

ISSN： 1932-6203
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI). International-journal Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

Medical science monitor : international medical journal of experimental and clinical research　23　5495-5503　2017/11/19

ISSN： 1234-1010

eISSN： 1643-3750

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BACKGROUND The optic radiation (OR) is a white-matter bundle connecting the lateral geniculate body and the visual cortex. Phase difference-enhanced imaging (PADRE) is a new MRI technique that is able to achieve precise delineation of the OR. The aim of this study was to investigate the effect of age on the volume and signal intensity of the OR using PADRE, and to establish a volumetric reference of the OR from a healthy population, compared with diffusion tensor imaging (DTI). MATERIAL AND METHODS Thirty-nine healthy volunteers underwent MR imaging with PADRE and DTI sequences on a 3.0-T scanner. For the volumetric analysis with PADRE, the OR corresponding to the external sagittal stratum was manually traced, while an automated thresholding method was used for the DTI-based volumetric analysis of the OR. RESULTS The mean right and left OR volumes measured from the PADRE images were 1469.0±242.4 mm³ and 1372.6±310.2 mm³, respectively. Although OR volume showed no significant correlation with age, the normalized OR signal intensity showed a linear correlation with increasing age (r²=0.50-0.53; P<0.01). The OR signal intensity on PADRE and DTI-related quantitative parameters for the OR showed significant correlations (r²=0.46-0.49; P<0.01). CONCLUSIONS The PADRE technique revealed exceptional preservation of OR volume, even in later life. Moreover, PADRE was able to detect age-related changes in signal intensity of the OR and may contribute to future analyses of pathological neurodegeneration in patients with glaucoma and multiple sclerosis.
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI) Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

MEDICAL SCIENCE MONITOR　23　5495-5503　2017/11

DOI： 10.12659/MSM.905571 　

ISSN： 1643-3750
Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress Peer-reviewed

Orie Nakamura, Satoru Moritoh, Kota Sato, Shigeto Maekawa, Namie Murayama, Noriko Himori, Kazuko Omodaka, Tetsuya Sogon, Toru Nakazawa

Clinical Ophthalmology　11　1825-1834　2017/10/11
Publisher: Dove Medical Press Ltd
DOI： 10.2147/OPTH.S145159 　

ISSN： 1177-5483 1177-5467
Usefulness of axonal tract-dependent OCT macular sectors for evaluating structural change in normal-tension glaucoma Peer-reviewed

Kazuko Omodaka, Tsutomu Kikawa, Yukihiro Shiga, Satoru Tsuda, Yu Yokoyama, Haruka Sato, Junko Ohuchi, Akiko Matsumoto, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa

PLOS ONE　12　(10)　e0185649　2017/10

DOI： 10.1371/journal.pone.0185649 　

ISSN： 1932-6203
Evaluation of retinal nerve fiber layer defect using wide-field en-face swept-source OCT images by applying the inner limiting membrane flattening Peer-reviewed

Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa

PLOS ONE　12　(10)　e0185573　2017/10

DOI： 10.1371/journal.pone.0185573 　

ISSN： 1932-6203
Evaluating retinal vessel diameter with optical coherence tomography in normal-tension glaucoma patients Peer-reviewed

Takeshi Yabana, Yukihiro Shiga, Ryo Kawasaki, Kazuko Omodaka, Hidetoshi Takahashi, Koudai Kimura, Kyosuke Togashi, Takaaki Horii, Kei Sasaki, Testuya Yuasa, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　61　(5)　378-387　2017/09

DOI： 10.1007/s10384-017-0523-z 　

ISSN： 0021-5155

eISSN： 1613-2246
Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation Peer-reviewed

Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　255　(8)　1633-1642　2017/08

DOI： 10.1007/s00417-017-3627-8 　

ISSN： 0721-832X

eISSN： 1435-702X
Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage Peer-reviewed

Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa

SCIENTIFIC REPORTS　7　(1)　8032　2017/08

DOI： 10.1038/s41598-017-08624-4 　

ISSN： 2045-2322
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-Angle Glaucoma Patients Peer-reviewed

Naoki Kiyota, Yukihiro Shiga, Shiori Suzuki, Marika Sato, Naoko Takada, Shigeto Maekawa, Kazuko Omodaka, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　58　(7)　3181-3188　2017/06

DOI： 10.1167/iovs.17-21648 　

ISSN： 0146-0404

eISSN： 1552-5783
Estimated retinal ganglion cell counts for assessing a wide range of glaucoma stages, from preperimetric to advanced Peer-reviewed

Mai Yamazaki, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　45　(3)　310-313　2017/04

DOI： 10.1111/ceo.12852 　

ISSN： 1442-6404

eISSN： 1442-9071
The neuroprotective effect of latanoprost acts via klotho-mediated suppression of calpain activation after optic nerve transection Peer-reviewed

Kotaro Yamamoto, Kota Sato, Masayoshi Yukita, Masayuki Yasuda, Kazuko Omodaka, Morin Ryu, Kosuke Fujita, Koji M. Nishiguchi, Shigeki Machida, Toru Nakazawa

JOURNAL OF NEUROCHEMISTRY　140　(3)　495-508　2017/02

DOI： 10.1111/jnc.13902 　

ISSN： 0022-3042

eISSN： 1471-4159
The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma Peer-reviewed

Noriko Himori, Hiroshi Kunikata, Ryo Kawasaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toshio Miyata, Toru Nakazawa

BRITISH JOURNAL OF OPHTHALMOLOGY　101　(2)　233-238　2017/02

DOI： 10.1136/bjophthalmol-2016-309504 　

ISSN： 0007-1161

eISSN： 1468-2079
Differentiation of glaucomatous optic discs with different appearances using optic disc topography parameters: The Glaucoma Stereo Analysis Study Peer-reviewed

Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Toru Nakazawa

PLOS ONE　12　(2)　e0169858　2017/02

DOI： 10.1371/journal.pone.0169858 　

ISSN： 1932-6203
Brimonidine Enhances the Electrophysiological Response of Retinal Ganglion Cells through the Trk-MAPK/ERK and PI3K Pathways in Axotomized Eyes Peer-reviewed

Masayoshi Yukita, Kazuko Omodaka, Shigeki Machida, Masayuki Yasuda, Kota Sato, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa

CURRENT EYE RESEARCH　42　(1)　125-133　2017/01

DOI： 10.3109/02713683.2016.1153112 　

ISSN： 0271-3683

eISSN： 1460-2202
Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma Peer-reviewed

Yukihiro Shiga, Hiroshi Kunikata, Naoko Aizawa, Naoki Kiyota, Yukiko Maiya, Yu Yokoyama, Kazuko Omodaka, Hidetoshi Takahashi, Tomoki Yasui, Keiichi Kato, Aiko Iwase, Toru Nakazawa

CURRENT EYE RESEARCH　41　(11)　1447-1453　2016/11

DOI： 10.3109/02713683.2015.1127974 　

ISSN： 0271-3683

eISSN： 1460-2202
The reduction of temporal optic nerve head microcirculation in autosomal dominant optic atrophy Peer-reviewed

Maki Inoue, Noriko Himori, Hiroshi Kunikata, Takayuki Takeshita, Naoko Aizawa, Yukihiro Shiga, Kazuko Omodaka, Koji M. Nishiguchi, Hidetoshi Takahashi, Toru Nakazawa

ACTA OPHTHALMOLOGICA　94　(7)　E580-E585　2016/11

DOI： 10.1111/aos.12999 　

ISSN： 1755-375X

eISSN： 1755-3768
Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography (vol 7, pg 3551, 2016) Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Naoko Aizawa, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　7　(11)　4636-4638　2016/11

DOI： 10.1364/BOE.7.004636 　

ISSN： 2156-7085
Estimation of Jones matrix, birefringence and entropy using Cloude-Pottier decomposition in polarization-sensitive optical coherence tomography Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Naoko Aizawa, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　7　(9)　3551-3573　2016/09

DOI： 10.1364/BOE.7.003551 　

ISSN： 2156-7085
Structure/function relationship between wide-scan binocular OCT images and the integrated visual field in glaucoma patients Peer-reviewed

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　44　(6)　526-528　2016/08

DOI： 10.1111/ceo.12701 　

ISSN： 1442-6404

eISSN： 1442-9071
OCT-Based Quantification and Classification of Optic Disc Structure in Glaucoma Patients Peer-reviewed

Naoko Takada, Kazuko Omodaka, Tsutomu Kikawa, Airi Takagi, Akiko Matsumoto, Yu Yokoyama, Yukihiro Shiga, Kazuichi Maruyama, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa

PLOS ONE　11　(8)　e0160226　2016/08

DOI： 10.1371/journal.pone.0160226 　

ISSN： 1932-6203
Transcriptome profiling of the rat retina after optic nerve transection Peer-reviewed

Masayuki Yasuda, Yuji Tanaka, Kazuko Omodaka, Koji M. Nishiguchi, Orie Nakamura, Satoru Tsuda, Toru Nakazawa

SCIENTIFIC REPORTS　6　28736　2016/06

DOI： 10.1038/srep28736 　

ISSN： 2045-2322
Estimated retinal ganglion cells counts are a valuable parameter in normal tension glaucoma Peer-reviewed

Mai Yamazaki, Kazuko Omodaka, Naoko Aizawa, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　44　(3)　207-209　2016/04

DOI： 10.1111/ceo.12656 　

ISSN： 1442-6404

eISSN： 1442-9071
Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography Peer-reviewed

Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba, Toru Nakazawa

PLOS ONE　11　(4)　e0153707　2016/04

DOI： 10.1371/journal.pone.0153707 　

ISSN： 1932-6203
Estimation of the Disc Damage Likelihood Scale in primary open-angle glaucoma: the Glaucoma Stereo Analysis Study Peer-reviewed

Yasushi Kitaoka, Masaki Tanito, Yu Yokoyama, Koji Nitta, Maki Katai, Kazuko Omodaka, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　254　(3)　523-528　2016/03

DOI： 10.1007/s00417-015-3239-0 　

ISSN： 0721-832X

eISSN： 1435-702X
The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma Peer-reviewed

Noriko Himori, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi, Toru Nakazawa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　254　(2)　333-341　2016/02

DOI： 10.1007/s00417-015-3203-z 　

ISSN： 0721-832X

eISSN： 1435-702X
Age- and Sex-Dependency of Laser Speckle Flowgraphy Measurements of Optic Nerve Vessel Microcirculation Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Fumihiko Nitta, Yukihiro Shiga, Kazuko Omodaka, Satoru Tsuda, Toru Nakazawa

PLOS ONE　11　(2)　e0148812　2016/02

DOI： 10.1371/journal.pone.0148812 　

ISSN： 1932-6203
Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma Peer-reviewed

Megumi Honjo, Kazuko Omodaka, Tatsuro Ishizaki, Shinji Ohkubo, Makoto Araie, Toru Nakazawa

PLOS ONE　10　(10)　e0141293　2015/10

DOI： 10.1371/journal.pone.0141293 　

ISSN： 1932-6203
Topographical Correlation Between Macular Layer Thickness and Clockwise Circumpapillary Retinal Nerve Fiber Layer Sectors in Patients with Normal Tension Glaucoma Peer-reviewed

Kazuko Omodaka, Yu Yokoyama, Yukihiro Shiga, Maki Inoue, Seri Takahashi, Satoru Tsuda, Kazuichi Maruyama, Toru Nakazawa

CURRENT EYE RESEARCH　40　(7)　744-751　2015/07

DOI： 10.3109/02713683.2014.956371 　

ISSN： 0271-3683

eISSN： 1460-2202
Characteristic correlations of the structure-function relationship in different glaucomatous disc types Peer-reviewed

Kazuko Omodaka, Naoko Takada, Takuhiro Yamaguchi, Hidetoshi Takahashi, Makoto Araie, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　59　(4)　223-229　2015/07

DOI： 10.1007/s10384-015-0379-z 　

ISSN： 0021-5155

eISSN： 1613-2246
Regional correlation of macular areas and visual acuity in patients with open-angle glaucoma Peer-reviewed

Kazuko Omodaka, Takeshi Yabana, Naoko Takada, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(3)　279-282　2015/04

DOI： 10.1111/ceo.12403 　

ISSN： 1442-6404

eISSN： 1442-9071
Regional susceptibility of the optic disc to retinal nerve fiber layer thinning in different optic disc types of eyes with normal tension glaucoma Peer-reviewed

Naoko Takada, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(3)　291-293　2015/04

DOI： 10.1111/ceo.12429 　

ISSN： 1442-6404

eISSN： 1442-9071
3D Evaluation of the Lamina Cribrosa with Swept-Source Optical Coherence Tomography in Normal Tension Glaucoma Peer-reviewed

Kazuko Omodaka, Takaaki Horii, Seri Takahashi, Tsutomu Kikawa, Akiko Matsumoto, Yukihiro Shiga, Kazuichi Maruyama, Tetsuya Yuasa, Masahiro Akiba, Toru Nakazawa

PLOS ONE　10　(4)　e0122347　2015/04

DOI： 10.1371/journal.pone.0122347 　

ISSN： 1932-6203
Fiber-based polarization-sensitive OCT for birefringence imaging of the anterior eye segment Peer-reviewed

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Yukihiro Shiga, Kazuko Omodaka, Yu Yokoyama, Noriko Himori, Morin Ryu, Shiho Kunimatsu-Sanuki, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

BIOMEDICAL OPTICS EXPRESS　6　(2)　369-389　2015/02

DOI： 10.1364/BOE.6.000369 　

ISSN： 2156-7085
Regional structural vulnerability of the macula in patients with normal tension glaucoma Peer-reviewed

Kazuko Omodaka, Naoko Takada, Hidetoshi Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　43　(1)　89-90　2015/01

DOI： 10.1111/ceo.12363 　

ISSN： 1442-6404

eISSN： 1442-9071
Assessment of Short-Term Changes in Optic Nerve Head Hemodynamics in Hyperoxic Conditions with Laser Speckle Flowgraphy Peer-reviewed

Yukihiro Shiga, Marika Sato, Kazuichi Maruyama, Shin Takayama, Kazuko Omodaka, Noriko Himori, Hiroshi Kunikata, Toru Nakazawa

CURRENT EYE RESEARCH　40　(10)　1055-1062　2015

DOI： 10.3109/02713683.2014.971934 　

ISSN： 0271-3683

eISSN： 1460-2202
Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma Peer-reviewed

Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2015　460918　2015

DOI： 10.1155/2015/460918 　

ISSN： 2090-004X

eISSN： 2090-0058
Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy Peer-reviewed

Satoru Tsuda, Hiroshi Kunikata, Masahiko Shimura, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Yu Yokoyama, Toru Nakazawa

CURRENT EYE RESEARCH　39　(12)　1207-1215　2014/12

DOI： 10.3109/02713683.2014.905608 　

ISSN： 0271-3683

eISSN： 1460-2202
Artemin Augments Survival and Axon Regeneration in Axotomized Retinal Ganglion Cells Peer-reviewed

Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Yuji Tanaka, Noriko Himori, Yu Yokoyama, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　92　(12)　1637-1646　2014/12

DOI： 10.1002/jnr.23449 　

ISSN： 0360-4012

eISSN： 1097-4547
The Novel Rho Kinase (ROCK) Inhibitor K-115: A New Candidate Drug for Neuroprotective Treatment in Glaucoma Peer-reviewed

Kotaro Yamamoto, Kazuichi Maruyama, Noriko Himori, Kazuko Omodaka, Yu Yokoyama, Yukihiro Shiga, Ryu Morin, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　55　(11)　7126-7136　2014/11

DOI： 10.1167/iovs.13-13842 　

ISSN： 0146-0404

eISSN： 1552-5783
Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling Peer-reviewed

Kazuko Omodaka, Koji M. Nishiguchi, Masayuki Yasuda, Yuji Tanaka, Kota Sato, Orie Nakamura, Kazuichi Maruyama, Toru Nakazawa

BRAIN RESEARCH　1586　203-212　2014/10

DOI： 10.1016/j.brainres.2014.08.053 　

ISSN： 0006-8993

eISSN： 1872-6240
Optic disc microcirculation in superior segmental optic hypoplasia assessed with laser speckle flowgraphy Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Kazuko Omodaka, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(7)　702-704　2014/09

DOI： 10.1111/ceo.12313 　

ISSN： 1442-6404

eISSN： 1442-9071
Critical Neuroprotective Roles of Heme Oxygenase-1 Induction Against Axonal Injury-Induced Retinal Ganglion Cell Death Peer-reviewed

Noriko Himori, Kazuichi Maruyama, Kotaro Yamamoto, Masayuki Yasuda, Morin Ryu, Kazuko Omodaka, Yukihiro Shiga, Yuji Tanaka, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　92　(9)　1134-1142　2014/09

DOI： 10.1002/jnr.23398 　

ISSN： 0360-4012

eISSN： 1097-4547
The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage Peer-reviewed

Yu Yokoyama, Kazuichi Maruyama, Kotaro Yamamoto, Kazuko Omodaka, Masayuki Yasuda, Noriko Himori, Morin Ryu, Koji M. Nishiguchi, Toru Nakazawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　451　(4)　510-515　2014/09

DOI： 10.1016/j.bbrc.2014.08.009 　

ISSN： 0006-291X

eISSN： 1090-2104
Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy Peer-reviewed

Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga, Yu Yokoyama, Kazuko Omodaka, Toru Nakazawa

BMC OPHTHALMOLOGY　14　113　2014/09

DOI： 10.1186/1471-2415-14-113 　

ISSN： 1471-2415
Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study Peer-reviewed

Yu Yokoyama, Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Kazuko Omodaka, Satoru Tsuda, Toshiaki Nakagawa, Toru Nakazawa

PLOS ONE　9　(6)　e99138　2014/06

DOI： 10.1371/journal.pone.0099138 　

ISSN： 1932-6203
Correlation of magnetic resonance imaging optic nerve parameters to optical coherence tomography and the visual field in glaucoma Peer-reviewed

Kazuko Omodaka, Takaki Murata, Shiho Sato, Mai Takahashi, Yasuko Tatewaki, Tatsuo Nagasaka, Hiroshi Doi, Makoto Araie, Shoki Takahashi, Toru Nakazawa

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　42　(4)　360-368　2014/05

DOI： 10.1111/ceo.12237 　

ISSN： 1442-6404

eISSN： 1442-9071
The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy. International-journal Peer-reviewed

Fumihiko Nitta, Hiroshi Kunikata, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Masayuki Yasuda, Toru Nakazawa

Clinical ophthalmology (Auckland, N.Z.)　8　1119-27　2014

DOI： 10.2147/OPTH.S62022 　

ISSN： 1177-5467

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BACKGROUND: This study evaluated the effect of intravitreal injection of bevacizumab (IVB) on macular edema associated with diabetic retinopathy (DME) or branch retinal vein occlusion (BRVOME) using laser speckle flowgraphy. METHODS: A comparative interventional study of 25 eyes from 22 patients with macular edema (DME group: 12 eyes; BRVOME group: 13 eyes) who underwent IVB. Mean blur rate (MBR) was measured in the retinal artery, retinal vein, optic nerve head (ONH), and choroid before and after IVB. RESULTS: In the BRVOME group, there was no significant change in MBR in the retinal artery, retinal vein or ONH, but choroidal MBR decreased significantly (P=0.04). In the DME group, the MBR in the retinal artery, retinal vein, ONH, and choroid decreased significantly (P=0.02, P=0.04, P<0.001, and P=0.04, respectively). In the DME group, pre-IVB MBR in the ONH was significantly correlated with post-IVB foveal thickness (R= -0.71, P=0.002). There was no such correlation in the BRVOME group in the ONH. CONCLUSION: IVB had a suppressive effect on circulation in eyes with DME but not in those with BRVOME. This suggests that this noninvasive and objective biomarker may be a useful part of pre-IVB evaluations and decision-making in DME.
Correlation of Optic Nerve Microcirculation with Papillomacular Bundle Structure in Treatment Naive Normal Tension Glaucoma Peer-reviewed

Wataru Kobayashi, Hiroshi Kunikata, Kazuko Omodaka, Kyousuke Togashi, Morin Ryu, Masahiro Akiba, Gaku Takeuchi, Tetsuya Yuasa, Toru Nakazawa

JOURNAL OF OPHTHALMOLOGY　2014　468908　2014

DOI： 10.1155/2014/468908 　

ISSN： 2090-004X

eISSN： 2090-0058
Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma. International-journal Peer-reviewed

Yukihiro Shiga, Kazuko Omodaka, Hiroshi Kunikata, Morin Ryu, Yu Yokoyama, Satoru Tsuda, Toshifumi Asano, Shigeto Maekawa, Kazuichi Maruyama, Toru Nakazawa

Investigative ophthalmology & visual science　54　(12)　7699-706　2013/11/21

DOI： 10.1167/iovs.13-12930 　

ISSN： 0146-0404

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PURPOSE: To investigate waveform changes in blood flow (BF) in the optic nerve head (ONH) and to evaluate their usefulness in identifying normal tension glaucoma (NTG). METHODS: Sixty-one eyes of 61 patients with NTG and 21 eyes of age-matched healthy control subjects were included in this study. The NTG eyes were divided into the following three groups based on the progression of their visual field defects: mild (mean deviation [MD] greater than -6.0 decibels [dB]), moderate (MD between -6.0 and -12.0 dB), and severe (MD less than -12.0 dB). The ONH BF analysis was performed with laser speckle flowgraphy (LSFG) and included waveform variables such as skew, acceleration time index (ATI), and blowout time. RESULTS: In the ONH, LSFG skew variables were significantly lower in the NTG eyes than in the control eyes (P < 0.001), and ATI was significantly higher (P < 0.01), despite similar systemic characteristics in the four groups. The differences were most marked in the mild NTG group. Multiple linear regression analysis showed that MD, average thickness of the circumpapillary retinal nerve fiber layer, and pulse rate were predictive factors for both skew and ATI. A receiver operating characteristic (ROC) curve analysis also revealed that skew (area under the ROC curve, 0.89) and ATI (area under the ROC curve, 0.80) had the greatest power to differentiate normal eyes from eyes with mild NTG. CONCLUSIONS: These results suggest that LSFG measurements of waveform changes in ONH BF can differentiate healthy eyes from eyes with NTG, particularly those with mild NTG.
Simulated Visual Fields Produced from Macular RNFLT Data in Patients with Glaucoma Peer-reviewed

Mai Takahashi, Kazuko Omodaka, Kazuichi Maruyama, Takuhiro Yamaguchi, Noriko Himori, Yukihiro Shiga, Morin Ryu, Hiroshi Kunikata, Toru Nakazawa

CURRENT EYE RESEARCH　38　(11)　1133-1141　2013/11

DOI： 10.3109/02713683.2013.807932 　

ISSN： 0271-3683
Development of a new strategy of visual field testing for macular dysfunction in patients with open angle glaucoma Peer-reviewed

Kazuko Omodaka, Shiho Kunimatsu-Sanuki, Ryu Morin, Satoru Tsuda, Yu Yokoyama, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

JAPANESE JOURNAL OF OPHTHALMOLOGY　57　(5)　457-462　2013/09

DOI： 10.1007/s10384-013-0258-4 　

ISSN： 0021-5155
The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy Peer-reviewed

Yukihiro Shiga, Masahiko Shimura, Toshifumi Asano, Satoru Tsuda, Yu Yokoyama, Naoko Aizawa, Kazuko Omodaka, Morin Ryu, Shunji Yokokura, Takayuki Takeshita, Toru Nakazawa

CURRENT EYE RESEARCH　38　(6)　691-698　2013/06

DOI： 10.3109/02713683.2012.758292 　

ISSN： 0271-3683
Progression of Visual Field Defects in Eyes With Different Optic Disc Appearances in Patients With Normal Tension Glaucoma Peer-reviewed

Toru Nakazawa, Masahiko Shimura, Morin Ryu, Noriko Himori, Fumihiko Nitta, Kazuko Omodaka, Hiroshi Doi, Tomoki Yasui, Nobuo Fuse, Kohji Nishida

JOURNAL OF GLAUCOMA　21　(6)　426-430　2012/08

DOI： 10.1097/IJG.0b013e3182182897 　

ISSN： 1057-0829
[Analysis of retinal nerve fiber layer thickness in superior segmental optic hypoplasia (SSOH)]. Peer-reviewed

Fuse N, Aizawa N, Yokoyama Y, Nakamura M, Omodaka K, Sado K, Nakazawa T

Nippon Ganka Gakkai zasshi　116　(6)　575-580　2012/06
Publisher:
ISSN： 0029-0203
Critical Role of Calpain in Axonal Damage-Induced Retinal Ganglion Cell Death Peer-reviewed

Morin Ryu, Masayuki Yasuda, Dong Shi, Ahmed Y. Shanab, Ryo Watanabe, Noriko Himori, Kazuko Omodaka, Yu Yokoyama, Jiro Takano, Takaomi Saido, Toru Nakazawa

JOURNAL OF NEUROSCIENCE RESEARCH　90　(4)　802-815　2012/04

DOI： 10.1002/jnr.22800 　

ISSN： 0360-4012
Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk Peer-reviewed

Yu Yokoyama, Naoko Aizawa, Naoki Chiba, Kazuko Omodaka, Masahiko Nakamura, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa

Clinical Ophthalmology　5　(1)　1721-1727　2011/12/06

DOI： 10.2147/OPTH.S23204 　

ISSN： 1177-5467 1177-5483
Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma. International-journal Peer-reviewed

Aizawa N, Yokoyama Y, Chiba N, Omodaka K, Yasuda M, Otomo T, Nakamura M, Fuse N, Nakazawa T

Clinical ophthalmology (Auckland, N.Z.)　5　1171-1176　2011

DOI： 10.2147/OPTH.S22093 　

ISSN： 1177-5467

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BACKGROUND: Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique. METHODS: Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 ± 11.2 years were examined in this study. Two parameters indicating reproducibility - the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) - were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 ± 12.8 years) and without (GHT-; 27 eyes, M:F = 13:14, average age 50.1 ± 8.7 years) abnormal glaucomatous visual fields. RESULTS: FOR ALL SUBJECTS, THE INTRASESSION REPRODUCIBILITY OF MBR IN THE OPTIC DISK (COV: 3.4 ± 2.0; ICC: 0.95) and choroid (COV: 4.7 ± 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 ± 5.6, ICC: 0.90) and retinal artery (COV: 10.9 ± 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 ± 2.0; ICC: 0.97) and the GHT- group (COV: 2.9 ± 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively). CONCLUSION: LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.
Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type. International-journal Peer-reviewed

Chiba N, Omodaka K, Yokoyama Y, Aizawa N, Tsuda S, Yasuda M, Otomo T, Yokokura S, Fuse N, Nakazawa T

Clinical ophthalmology (Auckland, N.Z.)　5　1549-1556　2011

DOI： 10.2147/OPTH.S22097 　

ISSN： 1177-5467

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BACKGROUND: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. METHODS: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard) was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. RESULTS: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P < 0.0001), r = -0.6208 (P < 0.0001), and r = 0.6010 (P = 0.0001), respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P < 0.0001), r = -0.6438 (P < 0.0001), and r = 0.6338 (P < 0.0001). CONCLUSION: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more highly correlated than the vessel area with other results of examination in glaucoma patients with the generalized enlargement disc type.
Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica Peer-reviewed

Masahiko Nakamura, Toru Nakazawa, Hiroshi Doi, Takehiro Hariya, Kazuko Omodaka, Tatsuro Misu, Toshiyuki Takahashi, Kazuo Fujihara, Kohji Nishida

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY　248　(12)　1777-1785　2010/12

DOI： 10.1007/s00417-010-1344-7 　

ISSN： 0721-832X
Correlation between peripapillary macular fiber layer thickness and visual acuity in patients with open-angle glaucoma. International-journal Peer-reviewed

Omodaka K, Nakazawa T, Yokoyama Y, Doi H, Fuse N, Nishida K

Clinical ophthalmology (Auckland, N.Z.)　4　629-635　2010/07

ISSN： 1177-5467

eISSN： 1177-5483

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PURPOSE: To determine whether the best-corrected visual acuity (BCVA) is significantly correlated with the retinal nerve fiber layer thickness (RNFLT) in the different peripapillary areas in eyes with open-angle glaucoma (OAG). PATIENTS AND METHODS: Two hundred twenty-nine eyes of 159 patients with OAG were studied. The overall RNFLT and the RNFLT in the superior (S), temporal (T), inferior (I), and nasal (N) quadrants were measured by Stratus optical coherence tomography (OCT). In addition, the temporal RNFLT was measured for three 30 degrees sectors with the mid-temporal (mT) sector at the three or nine o'clock position. The Spearman coefficient of correlation was calculated to determine whether a significant correlation existed between the RNFLT and the BCVA. Eyes with a BCVA <20/20 were classified as having decreased BCVA. RESULTS: There were significant correlations between the BCVA and the overall RNFLT, and also between the BCVA and the RNFLT in the T, I, and S quadrants. The coefficient correlation between the BCVA and RNFLT was the highest in the mT sector (r = -0.40, P < 0.0001). Forty-eight eyes (21.1%) were classified as having decreased BCVA. The cut-off value of the mT sector for eyes with decreased VA was 39.0 mum. CONCLUSION: The highest correlation between the BCVA and the RNFLT in the mT sector was most likely due to the location of the maculopapillary bundle in this region of the optic disc. Our findings indicate that when the RNFLT in the mT sector is reduced to 40 mum, glaucoma treatment should be reconsidered.
Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma. Peer-reviewed

Omodaka K, Nakazawa T, Otomo T, Nakamura M, Fuse N, Nishida K

Clinical ophthalmology (Auckland, N.Z.)　4　765-772　2010/07

ISSN： 1177-5467
Different types of optic disc shape in patients with advanced open-angle glaucoma Peer-reviewed

Toru Nakazawa, Nobuo Fuse, Kazuko Omodaka, Naoko Aizawa, Souichiro Kuwahara, Kohji Nishida

JAPANESE JOURNAL OF OPHTHALMOLOGY　54　(4)　291-295　2010/07

DOI： 10.1007/s10384-010-0816-y 　

ISSN： 0021-5155

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Misc. 166

Automated quantification of bleb scarring using anterior-segment polarization-sensitive optical coherence tomography

Satoru Tsuda, Hiroshi Kunikata, Masayuki Murakami, Masahiro Yamanari, Michiaki Okamoto, Suchandra Banerjee, Yu Yokoyama, Kazuko Omodaka, Noriko Himori, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　66　(8)　2025/06

ISSN： 0146-0404

eISSN： 1552-5783
Effects on ocular blood flow in brimonidine and Ripasudil

渡邊翔悟, 山口知暁, 清田直樹, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　129　2025

ISSN： 0029-0203
Prediction of glaucoma visual field progression based on non-time-series data

山口知暁, 安東弘泰, 二宮高洋, 高木愛理, 清田直樹, 津田聡, 面高宗子, 川上英良, 中澤徹

日本眼科学会雑誌　129　2025

ISSN： 0029-0203
AI-Driven Retinal Age Prediction and Relation to Systemic Diseases in Japan

杉田直紀, 二宮高洋, 羽生田明子, SHARMA Parmanand, 鈴木啓太, 野崎貴成, 面高宗子, 市川陽一, 中澤徹

日本眼科学会雑誌　129　2025

ISSN： 0029-0203
Relationship between corneal hysteresis and optic nerve head blood flow in OAG

武田瑶子, 羽入田明子, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　129　2025

ISSN： 0029-0203
Evaluation of glaucomatous changes in various areas of the primary visual cortex

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　129　2025

ISSN： 0029-0203
Evaluation of the Sensitivity of Central Visual Field within 10 Degrees in Open Angle Glaucoma Using ”Strip” Images

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　129　(5)　2025

ISSN： 0029-0203
Correlation Between Corneal Hysteresis and Optic Nerve Head Tissue Blood Flow in Eyes with Glaucoma

Yoko Takeda, Naoki Takahashi, Akiko Hanyuda, Kazuko Omodaka, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　65　(7)　2024/06

ISSN： 0146-0404

eISSN： 1552-5783
動脈炎性前部虚血性視神経症におけるLaser Speckle Flowgraphyの有用性

山口知暁, 檜森紀子, 檜森紀子, 清田直樹, 大島隆寛, 竹下孝之, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　40th　2024
Comparison of Superior and Inferior Microvasculature Dropout in Glaucoma

高橋哲, 高橋直樹, 津田聡, 面高宗子, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
Association between disc hemorrhage and optic nerve head blood flow in glaucoma

高橋直樹, 面高宗子, 羽入田明子, 武田瑶子, 津田聡, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
Relationship between CH and optic nerve head blood flow measured by LSFG in OAG.

武田瑶子, 高橋直樹, 羽入田明子, 面高宗子, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
Biological Age Prediction Using Retinal Images with Multi-Task Learning (MTL)

二宮高洋, SHARMA Parmanand, 羽入田明子, 鈴木啓太, 野崎貴成, 富山優介, 面高宗子, 市川陽一, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
Relationship between brain volume and myopia in glaucoma patients using MRI

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
Association between central visual field and papillomacular bundle in OAG

杉田直紀, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
レーザースペックルフローグラフィの画質判定におけるvascular cloudの有用性—Utility of Laser Speckle Flowgraphy-derived Vascular Cloud for Differentiating Poor Image Quality Data

清田直樹, 志賀由己浩, 二宮高洋, 山口知暁, 面高宗子, 中澤徹

日本眼科學會雜誌 = Journal of Japanese Ophthalmological Society　127　(5)　549-556　2023/05
Publisher: 東京 : 日本眼科学会
ISSN： 0029-0203
緑内障眼における傍乳頭脈絡膜微小血管脱落形成に関与する因子の検討

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼循環学会講演抄録集　39th　2023
視神経乳頭周囲組織血流に着目した緑内障における線維柱帯切除術後の視力低下

武田瑶子, 高橋直樹, 國分太貴, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　39th　2023
Laser speckle flowgraphyを用いた視神経症の鑑別についての検討

山口知暁, 清田直樹, 檜森紀子, 津田聡, 面高宗子, 中澤徹

日本眼循環学会講演抄録集　39th　2023
緑内障患者における中心窩無血管域(FAZ)と視野障害および全身因子との関連

二宮高洋, 面高宗子, 清田直樹, PARMANAND Sharma, 檜森紀子, 檜森紀子, 安田正幸, 國方彦志, 中澤徹

日本眼循環学会講演抄録集　39th　2023
Investigation of Intrachoroidal cavitation with SS-OCT

山口知暁, 高橋直樹, 面高宗子, 中澤徹

日本眼科学会雑誌　126　2022

ISSN： 0029-0203
Examination of the frequency of occurrence of DH in glaucoma patients by AI

面高宗子, 安光州, 安光州, 二宮高洋, 木川勉, 橋本和軌, 宮武博, 横田秀夫, 秋葉正博, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Development of an AI chatBOT for glaucoma

矢花武史, 二宮高洋, 前川重人, 檜森紀子, 面高宗子, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Calculation of pulse waves and autonomic nervous using videoplethysmography

佐々木栞菜, 前川重人, 面高宗子, 近藤美千子, 吉澤誠, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
The association between cornel hysteresis and stage of normal tension glaucoma

内田惠子, 檜森紀子, 國分太貴, 矢花武史, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Diagnostic power of 24plus (1) on the head-mounted perimeter imo

佐藤大夢, 面高宗子, 前川重人, 杉山真生, 新妻未央, 近藤美千子, 矢花武史, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Time-course Changes in Ocular Blood Flow and Glaucomatous Neurodegeneration

清田直樹, 志賀由己浩, 面高宗子, 朴慶純, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Investigation of RNFLB associated with visual acuity by SS-OCT

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Examination of macular OCTA parameters in glaucoma patients using AI

二宮高洋, 面高宗子, SHARMA Parmanand, 橋本和軌, 宮武博, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Association between Flammer Syndrome and blood flow in normal tension glaucoma

高橋成奈, 志賀由己浩, 清田直樹, 安田正幸, 面高宗子, 檜森紀子, 中澤徹

日本眼科学会雑誌　125　2021

ISSN： 0029-0203
Examination of the usefulness of Al-based FAZ measurement in glaucoma

二宮高洋, 面高宗子, PARMANAD Sharma, 橋本和軌, 宮武博, 中澤徹

日本緑内障学会抄録集　32nd　2021
Distribution of Glaucoma Risk Factors in Glaucoma Patients

蒲倉紗也佳, 面高宗子, 杉山真生, 高津育美, 二宮高洋, 中澤徹

日本緑内障学会抄録集　32nd　2021
The prevalence and risk factors of sleep apnea syndrome in patients with normal tension glaucoma

山崎舞, 山崎舞, 檜森紀子, 矢花武史, 國分太貴, 前川重人, 津田聡, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　32nd　2021
Reproducibility of macular vascular density (MVD) and relationship between MVD and glaucoma damage

加藤千穂, 面高宗子, 堀江寿雲, 東海林ひかり, 福岡世理, 大内順子, 中澤徹

日本緑内障学会抄録集　32nd　2021
Clinical characteristics of each glaucoma risk factor in glaucoma patients

面高宗子, 木川勉, AN Guangzhou, 二宮高洋, 蒲倉紗也佳, 杉山真生, 高津育美, 宮武博, 秋葉正博, 中澤徹

日本緑内障学会抄録集　32nd　2021
Association between OCT and visual field progression in glaucoma patients

高橋直樹, 面高宗子, 木川勉, 中澤徹

日本緑内障学会抄録集　32nd　2021
Association between endothelin-1 and visual field in normal tension glaucoma with Flammer Syndrome

高橋成奈, 佐藤孝太, 高田菜生子, 志賀由己浩, 清田直樹, 安田正幸, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　32nd　2021
Relationship between systemic circulatory diurnal variation and glaucoma by hemodynamic sensor

前川重人, 矢花武史, 檜森紀子, 面高宗子, 佐藤晶彦, 早瀬敏幸, 中澤徹

日本緑内障学会抄録集　32nd　2021
Changes in pupil diameter during visual field test of imo

佐藤大夢, 面高宗子, 前川重人, 杉山真生, 木幡未央, 矢花武史, 中澤徹

日本緑内障学会抄録集　32nd　2021
Evaluation of visual field progression by measurement of retinal nerve fiber layer defect angle

高橋直樹, 面高宗子, 中澤新, 木川勉, 中澤徹

日本緑内障学会抄録集　31st　2020
Long-term changes in optic disc parameters with stereo fundus camera in Nicolela’s classification

山田百合菜, 横山悠, 谷戸正樹, 新田耕治, 岩瀬愛子, 溝上志朗, 高井保幸, 面高宗子, 片井麻貴, 北岡康史, 内藤知子, 山下高明, 中澤徹

日本緑内障学会抄録集　31st　2020
Reproducibility of heart rate measuring device using video pulse wave extraction technology

三浦直晃, 前川重人, 近藤美千子, 面高宗子, 清水光久, 吉澤誠, 中澤徹

日本緑内障学会抄録集　31st　2020
Cytokine expression of activated microglia in mice retina following optic nerve crush mice

佐藤孝太, 横山悠, 檜森紀子, 面高宗子, 前川重人, 中澤徹

日本緑内障学会抄録集　31st　2020
Usefulness of nailfold capillary for the diagnosis of glaucoma

前川重人, 三浦直晃, 近藤美千子, 面高宗子, 待谷貴央, 武野團, 中澤徹

日本緑内障学会抄録集　31st　2020
Long-term changes in optic disc topography parameters determined by a stereo fundus camera

横山悠, 谷戸正樹, 新田耕治, 岩瀬愛子, 溝上志朗, 高井保幸, 面高宗子, 片井麻貴, 北岡康史, 内藤知子, 山下高明, 中澤徹

日本緑内障学会抄録集　31st　2020
Relationship between MRI of the primary visual cortex and estimated retinal ganglion cell count.

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　31st　2020
Deep learning predictions of visual field progression with GPA report

二宮高洋, 面高宗子, 橋本和軌, 高田菜生子, 矢花武史, 中澤徹

日本緑内障学会抄録集　31st　2020
緑内障患者における複合サプリメント摂取による酸化ストレス,抗酸化力の変動

檜森紀子, 柳町真希, 志賀由己浩, 面高宗子, 津田聡, 國方彦志, 中澤徹

日本抗加齢医学会総会プログラム・抄録集　20th　2020
Detecting glaucomatous change with magnetic resonance imaging of the brain primary visual cortex

Akio Yamada, Kazuko Omodaka, Yasuko Tatewaki, Noriko Himori, Izumi Matsudaira, Taki Yasuyuki, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　60　(9)　2019/07

ISSN： 0146-0404

eISSN： 1552-5783
Flammer症候群問診スコアと寒冷負荷試験に対する血管応答の関連

高橋成奈, 志賀由己浩, 清田直樹, 安田正幸, 佐藤茉莉華, 津田聡, 面高宗子, 檜森紀子, 高山真, 石井正, 中澤徹

日本眼科学会雑誌　123　(臨増)　221-221　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
高酸素血症時の血管応答性とその後の緑内障視野障害進行の関連

清田直樹, 志賀由己浩, 安田正幸, 相澤奈帆子, 面高宗子, 津田聡, 國方彦志, 中澤徹

日本眼科学会雑誌　123　(臨増)　156-156　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
健常者におけるOCT-Angiographyによるradial peripapillary capillary密度マップ

面高宗子, 木川勉, 浅野俊文, 津田聡, 國方彦志, 秋葉正博, 中澤徹

日本眼科学会雑誌　123　(臨増)　221-221　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障性視野障害の評価における深層学習の有用性の検討

二宮高洋, 面高宗子, 橋本和軌, 高田菜生子, 中澤徹

日本緑内障学会抄録集　30th　2019
MRIを用いた緑内障患者の眼球形態の検討

國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

日本疫学会学術総会講演集(Web)　29th　2019
en-Face Swept Source OCT画像による網膜神経線維層欠損面積の新規解析方法

高橋直樹, 面高宗子, 木川勉, 高橋世理, 秋葉正博, 中澤徹

日本眼科学会雑誌　123　2019

ISSN： 0029-0203
前眼部偏光OCTによる線維柱帯切除術後の濾過胞評価

國分太貴, 津田聡, 山成正宏, 國方彦志, 前川重人, 横山悠, 檜森紀子, 面高宗子, 中澤徹

日本緑内障学会抄録集　30th　2019
網膜神経節細胞複合体からマイクロペリメータMP-3を用いた網膜感度予測式の検討

菅野雅浩, 面高宗子, PAK Kyongsun, 山田祥之, 本田昂, 高津育美, 國方彦志, 本多直人, 中澤徹

日本緑内障学会抄録集　30th　2019
篩状板と緑内障

OMODAKA Kazuko, NAKAZAWA Toru

眼科　60　(11)　2018/10
POAGとNVGにおける線維柱帯切除術後の濾過胞構造変化の比較

國分太貴, 津田聡, 相澤奈帆子, 檜森紀子, 横山悠, 面高宗子, 国松志保, 國方彦志, 中澤徹

日本眼科学会雑誌　122　(臨増)　160-160　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
高眼圧眼における眼圧下降時の眼血流動態

志賀由己浩, 清田直樹, 面高宗子, 鈴木詩織, 國方彦志, 中澤徹

日本眼科学会雑誌　122　(臨増)　211-211　2018/03/09
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
OCT‐Angiographyによるradial peripapillary capillary密度の緑内障診断力

津田聡, 面高宗子, 木川勉, 浅野俊文, 國方彦志, 相見太樹, 秋葉正博, 中澤徹

日本眼科学会雑誌　122　(臨増)　211-211　2018/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ステレオ眼底カメラにより計測した網膜血管径および視神経乳頭形状パラメーターの関連

杉原一暢, 高井保幸, 谷戸正樹, 川崎良, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹, 大平明弘

眼科臨床紀要　11　(3)　236-236　2018/03
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
ステレオ眼底カメラにより分類した緑内障視神経乳頭形状分類と網膜血管径の関連

高井保幸, 杉原一暢, 谷戸正樹, 川崎良, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹, 大平明弘

眼科臨床紀要　11　(3)　236-236　2018/03
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
線維柱帯切除術施行患者における全身循環動態の検討

二宮高洋, 津田聡, 國分太貴, 志賀由己浩, 面高宗子, 檜森紀子, 横山悠, 国松志保, 中澤徹

日本緑内障学会抄録集　29th　2018
緑内障における乳頭黄斑神経線維束厚と視力低下の関連

高橋直樹, 面高宗子, 福岡世理, 木川勉, 秋葉正博, 中澤徹

日本緑内障学会抄録集　29th　2018
視放線における緑内障性神経変化のDTI-NODDIによる検出

山田晃生, 面高宗子, 舘脇康子, 松平泉, 下地啓五, 齊藤麻美, 川島隆太, 瀧靖之, 中澤徹

日本緑内障学会抄録集　29th　2018
3D立体構造における篩状板孔の主成分解析や真球度について

前川重人, 面高宗子, AN Guangzhou, AN Guangzhou, 松本朗子, 木川勉, 木川勉, 秋葉正博, 秋葉正博, 横田秀夫, 中澤徹

日本緑内障学会抄録集　29th　2018
ブリモニジンまたはチモロールで24ヶ月間治療された原発開放隅角緑内障における視野障害進行関連因子の検討

横山悠, 川崎良, 高橋秀肇, 前川重人, 津田聡, 面高宗子, 中澤徹

日本緑内障学会抄録集　29th　2018
OCTAを用いた放射状乳頭周囲血管網の血管密度解析の再現性の検討

新妻未央, 面高宗子, 福岡世理, 吉田みなみ, 山本光男, 中澤徹

日本緑内障学会抄録集　29th　2018
正常眼における篩状板部血管密度の計測方法の検討

河本絵里香, 面高宗子, 堀江寿雲, 福岡世理, 中澤徹

日本緑内障学会抄録集　29th　2018
タフルプロスト徐放性製剤によるラット網膜神経節細胞への神経保護効果の検討

中川優梨花, 佐藤孝太, 面高宗子, 浅田博之, 藤井忍, 眞崎賢治, 中澤徹

日本緑内障学会抄録集　29th　2018
緑内障患者におけるFlammer問診票の有用性

高橋成奈, 志賀由己浩, 安田正幸, 佐藤茉莉華, 清田直樹, 津田聡, 面高宗子, 檜森紀子, 高山真, 石井正, 中澤徹

日本緑内障学会抄録集　29th　2018
緑内障患者のベースライン4分割視神経乳頭組織血流が対応する部位の視野進行に与える影響

清田直樹, 志賀由己浩, 安田正幸, 相澤奈帆子, 面高宗子, 津田聡, 檜森紀子, 國方彦志, 中澤徹

日本緑内障学会抄録集　29th　76　2018
中心視野障害を伴う緑内障患者の黄斑部OCTAパラメーター

佐藤里咲, 國方彦志, 面高宗子, 浅野俊文, 志賀由己浩, 木川勉, 秋葉正博, 中澤徹

日本緑内障学会抄録集　29th　115　2018
前視野緑内障眼での視野進行に関与する因子の検討

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 国松志保, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　29th　76　2018
マイクロペリメータMP‐3の網膜感度とRGC displacementを考慮した黄斑部網膜層厚との相関

本田昂, 面高宗子, 石川奈津美, 本多直人, 山田祥之, 國方彦志, 中澤徹

日本緑内障学会抄録集　29th　79　2018
Ocular blood flow in glaucoma

59　(6)　573-580　2017/06
Publisher: 金原出版
ISSN： 0016-4488
Classification of optic disc shape in glaucoma using machine learning based on quantified ocular parameters from ophthalmic examination instruments

117　(47)　63-66　2017/05/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
前視野緑内障眼における中心視野障害進行と視神経乳頭組織血流の関係性

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　121　(臨増)　206-206　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における抗酸化力と網膜神経節細胞数の関係

浅野良視, 檜森紀子, 山崎舞, 志賀由己浩, 面高宗子, 國方彦志, 中澤徹

日本眼科学会雑誌　121　(臨増)　185-185　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
光干渉断層計アンギオグラフィーとレーザースペックルフローグラフィーの有用性の比較

清田直樹, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本眼科学会雑誌　121　(臨増)　211-211　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
MRIにおける広範な脳視覚野の緑内障性変化と部位間の相関

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本眼科学会雑誌　121　(臨増)　225-225　2017/03/08
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者におけるMRIの視覚野体積と視野重症度との関連

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　28th　2017
ステレオ眼底カメラで計測した視神経乳頭形状パラメータと乳頭周囲網脈絡膜萎縮面積を用いた乳頭形状分類

藤岡俊亮, 横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 中澤徹, 岩瀬愛子

日本緑内障学会抄録集　28th　2017
en-Face Swept Source OCT画像による網膜神経線維層欠損角度の新規解析方法

遠藤拓弥, 面高宗子, 木川勉, 三浦直晃, 高橋世理, 秋葉正博, 中澤徹

日本緑内障学会抄録集　28th　2017
広義原発開放隅角緑内障眼における乳頭周囲網脈絡膜萎縮面積と視神経乳頭形状の関連

横山悠, 谷戸正樹, 新田耕治, 片井麻貴, 北岡康史, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　28th　2017
ステレオ眼底カメラにより分類した緑内障視神経乳頭形状と網膜血管径の関連

高井保幸, 杉原一暢, 谷戸正樹, 川崎良, 大平明弘, 新田耕治, 片井麻貴, 北岡康史, 横山悠, 面高宗子, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 大久保真司, 松本長太, 杉山和久, 中澤徹

日本緑内障学会抄録集　28th　2017
緑内障患者の前房水中サイトカインのプロファイルの検討

國分太貴, 津田聡, 國方彦志, 横山悠, 面高宗子, 檜森紀子, 国松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　121　(1)　93-93　2017/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Inhibition of Sp1 signaling promotes retinal ganglion cell death via apoptotic and necrotic pathways in a model of glaucoma

Kota Sato, Yukihiro Shiga, Kazuko Omodaka, Shigeto Maekawa, Namie Murayama, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma

Naoko Aizawa, Yukihiro Shiga, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Glaucoma

Naoki Kiyota, Yukihiro Shiga, Marika Sato, Shigeto Maekwa, Kazuko Omodaka, Kazuichi Maruyama, Hidetoshi Takahashi, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Imaging of scar tissue in the filtering bleb by anterior-segment polarization-sensitive OCT

Masahiro Yamanari, Satoru Tsuda, Taiki Kokubun, Kazuko Omodaka, Yu Yokoyama, Noriko Himori, Shiho Kunimatsu-Sanuki, Kazuichi Maruyama, Hiroshi Kunikata, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Lamina cribrosa thinning in glaucoma and associated factors

Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Shiori Suzuki, Yukihiro Shiga, Tsutomu Kikawa, Kazuichi Maruyama, Masahiro Akiba, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
The structure/function relationship between wide-scan binocular OCT images and the binocular visual field in glaucoma patients

Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma study 2: The relationship between optic nerve head blood flow and visual field progression in preperimetric glaucoma

Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Kazuko Omodaka, Yu Yokoyama, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　57　(12)　2016/09

ISSN： 0146-0404

eISSN： 1552-5783
正常眼圧緑内障患者における酸化ストレスマーカーと視神経乳頭循環

檜森紀子, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本酸化ストレス学会学術集会プログラム・抄録集　69th　156　2016/08/30
緑内障患者における酸化ストレスと視野

國方彦志, 檜森紀子, 川崎良, 志賀由己浩, 面高宗子, 高木愛理, 中澤徹

日本酸化ストレス学会学術集会プログラム・抄録集　69th　155　2016/08/30
濾過胞観察におけるOCT減衰係数画像の有用性の検討

國分太貴, 國分太貴, 津田聡, 山成正宏, 國方彦志, 面高宗子, 横山悠, 檜森紀子, 國松志保, 丸山和一, 中澤徹

日本眼科学会雑誌　120　(臨増)　169-169　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障眼における酸素吸入時の視神経乳頭血流動態

清田直樹, 志賀由己浩, 鈴木詩織, 佐藤茉莉華, 高田菜生子, 前川重人, 面高宗子, 丸山和一, 高橋秀肇, 國方彦志, 中澤徹

日本眼科学会雑誌　120　(臨増)　166-166　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における酸化ストレスと抗酸化力

檜森紀子, 志賀由己浩, 面高宗子, 國方彦志, 高木愛梨, 川崎良, 中澤徹

日本眼科学会雑誌　120　(臨増)　168-168　2016/03/02
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ラット視神経挫滅モデルの網膜トランスクリプトーム解析

安田正幸, 西口康二, 面高宗子, 田中佑治, 中澤徹

日本眼科学会雑誌　120　(臨増)　246-246　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
極早期緑内障眼における視野障害進行に及ぼす背景因子の検討

志賀由己浩, 相澤奈帆子, 津田聡, 清田直樹, 前川重人, 面高宗子, 横山悠, 国松志保, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　27th　2016
緑内障進行判定におけるOCT黄斑部セクター解析の有用性

面高宗子, 大内順子, 佐藤はる香, 木川勉, 志賀由己浩, 横山悠, 松本朗子, 丸山和一, 秋葉正博, 中澤徹

日本眼科学会雑誌　120　2016

ISSN： 0029-0203
緑内障背景因子とSS-OCT視神経乳頭形状パラメータによる乳頭形状自動分類

高田菜生子, 面高宗子, 横山悠, 鎌田泰彰, 木川勉, 松本朗子, 丸山和一, 秋葉正博, 中澤徹

日本眼科学会雑誌　120　2016

ISSN： 0029-0203
篩状板厚と緑内障パラメータの関連について

前川重人, 面高宗子, 高橋世理, 鈴木詩織, 松本朗子, 木川勉, 志賀由己浩, 横山悠, 丸山和一, 秋葉正博, 中澤徹

日本眼科学会雑誌　120　2016

ISSN： 0029-0203
フラボノイドによる網膜興奮毒性障害モデルに対する神経保護作用

前川重人, 佐藤孝太, 村山奈美枝, 藤田幸輔, 西口康二, 大学玲子, 丸山和一, 志賀由己浩, 面高宗子, 中澤徹

日本緑内障学会抄録集　27th　2016
緑内障性中心障害における実用視力の検討

佐藤はる香, 大内順子, 面高宗子, 大里哲也, 國方彦志, 中澤徹

日本緑内障学会抄録集　27th　80　2016
極早期緑内障病態研究 1:極早期緑内障における視野進行と視神経乳頭血流の関係性

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　27th　162　2016
レーザースペックルフローグラフィーと光干渉断層計アンギオグラフィーの血流パラメータの関係性

清田直樹, 國方彦志, 志賀由己浩, 面高宗子, 中澤徹

日本緑内障学会抄録集　27th　163　2016
緑内障患者における睡眠時無呼吸症候群と酸化ストレスとの関連

山田絵里香, 檜森紀子, 山崎舞, 面高宗子, 國方彦志, 長澤美穂, 小川浩正, 一ノ瀬和, 中澤徹

日本緑内障学会抄録集　27th　202　2016
緑内障患者の前房水中サイトカインのプロファイルの検討

國分太貴, 津田聡, 國方彦志, 横山悠, 面高宗子, 檜森紀子, 国松志保, 丸山和一, 中澤徹

日本緑内障学会抄録集　27th　71　2016
PPGを含めた緑内障性障害におけるEstimated RGC countの有用性

山崎舞, 面高宗子, 吉田みなみ, 相澤奈帆子, 國方彦志, 中澤徹

日本緑内障学会抄録集　27th　78　2016
MRIにおける眼窩内視神経断面積の緑内障性変化

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
MRIにおける脳一次視覚野の緑内障性変化

面高宗子, 福田麻奈, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
Effect of a PG analogue on optic nerve head blood flow in eyes with preperimetric glaucoma

Naoki Kiyota, Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma pathophysiological study part1:Twelve-month results of topical prostaglandin analogues

Naoko Aizawa, Hiroshi Kunikata, Satoru Tsuda, Yukihiro Shiga, Yukiko Maiya, Naoki Kiyota, Kazuko Omodaka, Yu Yokoyama, Morin Ryu, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Role of GDNF receptor-related genes to axonal damage-induced retinal ganglion cell death and regeneration

Kazuko Omodaka, Takuji Kurimoto, Orie Nakamura, Kota Sato, Masayuki Yasuda, Noriko Himori, Yu Yokoyama, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Preperimetric glaucoma pathophysiological study part4: Significant reduction in optic nerve head blood flow

Yukiko Maiya, Yukihiro Shiga, Naoko Aizawa, Satoru Tsuda, Yu Yokoyama, Kazuko Omodaka, Tomoki Yasui, Keiichi Kato, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
LSFG-measured reduction of temporal optic disc circulation in ADOA patients

Maki Inoue, Noriko Himori, Takayuki Takeshita, Naoko Aizawa, Kazuko Omodaka, Yukihiro Shiga, Kazuichi Maruyama, Koji Nishiguchi, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　56　(7)　2015/06

ISSN： 0146-0404

eISSN： 1552-5783
Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study (vol 9, e99138, 2014)

Y. Yokoyama, M. Tanito, K. Nitta, M. Katai, Y. Kitaoka, K. Omodaka

PLOS ONE　10　(4)　2015/04

DOI： 10.1371/journal.pone.0124703 　

ISSN： 1932-6203
極早期緑内障病態研究 1:プロスタグランジン関連薬による12カ月長期治療成績

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 清田直樹, 米谷優輝子, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本眼科学会雑誌　119　(臨増)　230-230　2015/03/18
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Aiming for Zero Blindness

中澤徹, 國方彦志, 横倉俊二, 丸山和一, 西口康二, 高橋秀肇, 国松志保, 劉孟林, 檜森紀子, 田中佑治, 新田文彦, 森藤暁, 藤田幸輔, 中村織江, 面高宗子, 安田正幸, 横山悠, 相澤奈帆子, 山本耕太郎, 雪田昌克, 津田聡, 志賀由己浩, 前川重人, 國分太貴, 今野瑛之, 高橋麻衣, 萱場寛子, 橋本清香, 佐藤茉莉華, 矢花武史, 高田菜生子, 高橋世理, 鎌田泰彰, 秋葉正博, 木川勉, 松本朗子, 新家眞, 石橋達朗, 立花崇, 岩瀬愛子

日本眼科学会雑誌　119　(3)　168-193　2015/03/10
Publisher: 日本眼科学会
ISSN： 0029-0203
RNAシークエンスを用いたラット視神経軸索障害モデルの網膜トランスクリプトーム解析

安田正幸, 西口康二, 面高宗子, 田中佑治, 中澤徹

日本眼科学会雑誌　119　(臨増)　242-242　2015/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
voxel based morphometry(VBM)を用いた緑内障における脳視路変性の検討

舘脇康子, 村田隆紀, 麦倉俊司, 高橋昭喜, 瀧靖之, 関口敦, 面高宗子, 中澤徹

Japanese Journal of Radiology　33　(Suppl.)　9-9　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
ステレオ眼底写真を用いた乳頭内血管面積評価と緑内障眼における有用性

清田直樹, 志賀由己浩, 原拓也, 畠山靖祥, 面高宗子, 横山悠, 中澤徹

日本緑内障学会抄録集　26th　2015
Swept Source Octでの視神経乳頭形状パラメータ測定における参照面高の検討

高田菜生子, 面高宗子, 横山悠, 鎌田泰彰, 木川勉, 松本明子, 高橋秀肇, 丸山和一, 秋葉正博, 中澤徹

日本眼科学会雑誌　119　2015

ISSN： 0029-0203
LSFGを用いた常染色体優性視神経萎縮における視神経乳頭耳側の血流低下の検討

井上真希, 檜森紀子, 竹下孝之, 相澤奈帆子, 面高宗子, 志賀由己浩, 丸山和一, 西口康二, 中澤徹

日本眼科学会雑誌　119　2015

ISSN： 0029-0203
OCT黄斑部のセクター解析による緑内障進行判定の有用性

面高宗子, 大内順子, 木川勉, 志賀由己浩, 横山悠, 松本朗子, 木村鴻大, 丸山和一, 湯浅哲也, 秋葉正博, 中澤徹

日本緑内障学会抄録集　26th　2015
篩状板厚における簡易計測の有用性の検討

高橋世理, 面高宗子, 堀井高明, 木川勉, 松本朗子, 志賀由己浩, 横山悠, 丸山和一, 湯浅哲也, 秋葉正博, 中澤徹

日本緑内障学会抄録集　26th　2015
Swept-source OCTを用いた視神経乳頭形状の客観的分類のバリデーション

高田菜生子, 面高宗子, 木川勉, 松本朗子, 鎌田泰彰, 横山悠, 高橋秀肇, 丸山和一, 秋葉正博, 中澤徹

日本緑内障学会抄録集　26th　2015
緑内障モデル動物における神経節細胞死とネクロプトーシス経路の関与

佐藤孝太, 志賀由己浩, 面高宗子, 前川重人, 村山奈美枝, 中澤徹

日本緑内障学会抄録集　26th　2015
マウス視神経挫滅モデルの網膜神経節細胞障害におけるECEL1の関与

志賀由己浩, 佐藤孝太, 前川重人, 面高宗子, 丸山和一, 西口康二, 中澤徹

日本緑内障学会抄録集　26th　2015
緑内障眼における色視力測定の検討

大内順子, 面高宗子, 佐藤はる香, 大里哲也, 佐藤裕之, 伊藤梓, 相澤奈帆子, 田中芳樹, 國方彦志, 市川一夫, 中澤徹

日本緑内障学会抄録集　26th　108-108　2015
Publisher: 日本緑内障学会
偏光OCTによる濾過胞内の複屈折の定量評価と術後成績の関係

國分太貴, 國分太貴, 國方彦志, 山成正宏, 面高宗子, 檜森紀子, 国松志保, 劉孟林, 高橋秀肇, 丸山和一, 中澤徹

日本緑内障学会抄録集　26th　142-142　2015
Publisher: 日本緑内障学会
極早期緑内障患者に対するタフルプロスト点眼液による治療成績と視野障害発症症例の患者背景

相澤奈帆子, 國方彦志, 志賀由己浩, 津田聡, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　26th　123-123　2015
Publisher: 日本緑内障学会
緑内障の診断におけるEstimated RGC countの有用性

山崎舞, 面高宗子, 相澤奈帆子, 國方彦志, 中澤徹

日本緑内障学会抄録集　26th　106-106　2015
Publisher: 日本緑内障学会
正常眼圧緑内障患者における酸化ストレスと視神経乳頭循環との関連

檜森紀子, 志賀由己浩, 面高宗子, 相澤奈帆子, 丸山和一, 國方彦志, 中澤徹

日本緑内障学会抄録集　26th　151-151　2015
Publisher: 日本緑内障学会
LSFGを用いた正常人における酸素吸入時の視神経乳頭血流動態評価

佐藤茉莉華, 志賀由己浩, 丸山和一, 高山真, 面高宗子, 檜森紀子, 國方彦志, 中澤徹

日本緑内障学会抄録集　25回　86-86　2014/09
Publisher: 日本緑内障学会
マウス軸索障害に対するheme oxygenase-1の内在性神経保護作用

檜森紀子, 丸山和一, 山本耕太郎, 安田正幸, 劉孟林, 面高宗子, 志賀由己浩, 中澤徹

日本抗加齢医学会総会プログラム・抄録集　14回　324-324　2014/06
Publisher: (一社)日本抗加齢医学会
レーザースペックル眼底血流検査による血流動態が緑内障に与える影響

高橋秀肇, 志賀由己浩, 面高宗子, 高橋麻衣, 相澤奈帆子, 國方彦志, 中澤徹

日本眼科学会雑誌　118　(臨増)　160-160　2014/03/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者における視神経・視放線の拡散テンソル解析の試み

村田隆紀, 佐藤志帆, 舘脇康子, 麦倉俊司, 高橋昭喜, 面高宗子, 土井洋, 中澤徹, 大友孝昭

Jpn J Radiol　32　(Supplement)　9-9　2014/02/25
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071

eISSN： 1867-108X
Registration Algorithm of Fundus Oculi for 3-D Optical Coherence Tomography Images

TOGASHI Kyosuke, SAKAMOTO Miki, TAKEUCHI Gaku, AKIBA Masahiro, YABANA Takeshi, OMODAKA Kazuko, RYU Morin, TSUDA Satoru, YOKOYAMA Yu, FUKUMA Yasufumi, NAKAZAWA Toru, YUASA Tetsuya

IEICE technical report.　113　(410)　133-137　2014/01/26
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Recently, retinal nerve fiber layer (RNFL) thickness measurement from retinal optical coherence tomography (OCT) images has been widely used as an important clinical index to indicate a glaucoma progression. While a long-term follow-up of RNFL thickness is effective tool for glaucoma diagnosis, a precise registration is indispensable for OCT images acquired at different date. In this study, we propose a registration algorithm to correct random shifts occurring whenever imaging based on a projection image generated from the 3-D OCT retinal images. For speeding-up, the algorithm was implemented by processing in Fourier space based on properties of Fourier transform with rotation and translation, which is referred to as phase-only correlation method. For the stable detection of shift, several preprocessing to raw data, such as background correction to homogenize different imaging conditions, zero-padding to resize the registration image from a rectangular to a square image size, and Hanning-windowing to suppress unnecessary higher frequency-components, were carefully applied before registration. We demonstrated the effectiveness of the proposed method using an actual retina image (512×885×64) of a healthy volunteer acquired by 3-D OCT-2000 manufactured by TOPCON, Japan. The measurement was repeated 10 times, and the degree of agreement in RNFL thickness measured was evaluated with root mean square (RMS). The average RMS before and after preregistration were 4.7±1.6 and 2.6±0.3 μm, respectively. From this result, it can be concluded that the proposed method improved the precision approximately twofold. In addition, the processing time was approximately 0.3 s for a single data set, which will fall inside a permissible range of clinical use. Proposed technique may become a useful tool for glaucoma diagnosis.
Brimonidineによるラット網膜神経節細胞のNeuroactivation

雪田昌克, 面高宗子, 町田繁樹, 丸山和一, 中澤徹

日本眼科学会雑誌　118　2014

ISSN： 0029-0203
Swept-source OCTを用いた新たな視神経乳頭形状自動分類方法の有用性の検討

高田菜生子, 面高宗子, 木川勉, 松本朗子, 鎌田泰彰, 横山悠, 高橋秀筆, 丸山和一, 秋葉正博, 中澤徹

日本緑内障学会抄録集　25th　2014
ビルベリーアントシアニンはERシャペロン調節を介して網膜神経節細胞死を抑制する

中村織江, 檜森紀子, 面高宗子, 森藤暁, 中澤徹, 中澤徹

日本生化学会大会(Web)　87th　2014
極早期緑内障病態研究 2:極早期緑内障患者における視神経乳頭血流の薬剤反応性

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 清田直樹, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　25th　86　2014
ステレオ眼底カメラにより測定した視神経乳頭リム偏心率と他のパラメーターの相関

片井麻貴, 谷戸正樹, 新田耕治, 北岡康史, 横山悠, 面高宗子, 津田聡, 中川俊明, 内藤知子, 山下高明, 溝上志朗, 岩瀬愛子, 中澤徹

日本緑内障学会抄録集　24回　60-60　2013/09
Publisher: 日本緑内障学会
上方視神経低形成の視神経乳頭血流

相澤奈帆子, 國方彦志, 面高宗子, 檜森紀子, 中澤徹

日本眼科学会雑誌　117　(臨増)　270-270　2013/03/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
前眼部3次元OCTを用いた線維柱帯切除術後の濾過胞の評価

國分太貴, 津田聡, 浅野俊文, 横山悠, 面高宗子, 多田麻子, 渡邉亮, 劉孟林, 國松志保, 高橋秀肇, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　338-338　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
線維柱帯切除後の濾過胞における経時的結膜血管面積の定量化

浅野俊文, 津田聡, 國分太貴, 横山悠, 面高宗子, 渡邉亮, 劉孟林, 国松志保, 高橋秀肇, 丸山和一, 中澤徹

日本眼科学会雑誌　117　(臨増)　340-340　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
エリスロポエチンノックアウトマウスを用いた網膜・視神経の組織学的検討

安田正幸, 劉孟林, 田中佑治, 檜森紀子, 面高宗子, 横山悠, 雪田昌克, 津田聡, 丸山和一, 山本雅之, 中澤徹

日本眼科学会雑誌　117　(臨増)　311-311　2013/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
ラット視神経切断後早期の電気生理学・分子生物学的検討

雪田昌克, 面高宗子, 丸山和一, 町田繁樹, 中澤徹

日本緑内障学会抄録集　24th　2013
ミニ知識コーナー知っておくと得をするRetina百科(第2回)OCTの緑内障評価に役立つ知識

面高宗子, 中澤徹

Retina medicine : journal of retina medeicine : 網膜・硝子体領域を中心とした医学情報誌　2　(1)　114-116　2013
Publisher: 先端医学社
ISSN： 2187-2384
OCT 緑内障診療におけるOCTの活用

横山悠, 面高宗子, 中澤徹

Monthly Book Oculista　2　69-77　2013/01
極早期緑内障患者における視神経乳頭血流の薬剤反応性

相澤奈帆子, 國方彦志, 津田聡, 志賀由己浩, 面高宗子, 横山悠, 劉孟林, 安井朝輝, 加藤圭一, 中澤徹

日本緑内障学会抄録集　24th　115　2013
局所虚血型緑内障における乳頭周囲網膜神経線維層厚菲薄化の血流閾値

津田聡, 横山悠, 國分太貴, 面高宗子, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　154-154　2012/09
Publisher: 日本緑内障学会
緑内障眼における視神経乳頭循環と脈絡膜循環の血流波形の差異

國分太貴, 津田聡, 志賀由己浩, 横山悠, 面高宗子, 前川重人, 渡邊亮, 劉孟林, 国松志保, 高橋秀肇, 中澤徹

日本緑内障学会抄録集　23回　159-159　2012/09
Publisher: 日本緑内障学会
軸索流障害による網膜神経節細胞死のcalpain pathwayの関与

劉孟林, 横山悠, 安田正幸, アハメッド・シャナブ, 檜森紀子, 面高宗子, 渡辺亮, 高野二郎, 西道隆臣, 中澤徹

日本緑内障学会抄録集　23回　102-102　2012/09
Publisher: 日本緑内障学会
正常眼圧緑内障における進行予測因子としての皮膚AGEの有用性

金澤紘子, 劉孟林, 安田正幸, 面高宗子, 橋本清香, 國分太貴, 今野瑛之, 宮田敏男, 佐藤肇, 中澤徹

日本緑内障学会抄録集　23回　112-112　2012/09
Publisher: 日本緑内障学会
アポリポ蛋白質E欠損マウスにおけるカイニン酸障害および軸索障害に対する網膜神経節細胞の保護効果

田中佑治, Ahmed Shanab, 安田正幸, 面高宗子, 横山悠, 劉孟林, 中澤徹

日本緑内障学会抄録集　23回　152-152　2012/09
Publisher: 日本緑内障学会
DNAマイクロアレイによるラタノプロストの神経保護作用の解析

山本耕太郎, 劉孟林, 面高宗子, 安田正幸, 中澤徹

日本緑内障学会抄録集　23回　153-153　2012/09
Publisher: 日本緑内障学会
緑内障患者のMRIにおける視神経評価の有用性

高橋麻衣, 面高宗子, 土井洋, 村田隆紀, 佐藤志保, 舘脇康子, 劉孟林, 国松志保, 高橋昭喜, 中澤徹

日本緑内障学会抄録集　23回　126-126　2012/09
Publisher: 日本緑内障学会
酸化ストレス研究における網膜神経節細胞純化回収法の確立

檜森紀子, 田口恵子, 劉孟林, 安田正幸, 横山悠, 相澤奈帆子, 面高宗子, 山本雅之, 中澤徹

日本眼科学会雑誌　116　(臨増)　303-303　2012/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者の視放線のMRIパラメータと両眼視野との相関

面高宗子, 土井洋, 大友孝昭, 村田隆紀, 佐藤志保, 舘脇康子, 永坂竜男, 国松志保, 高橋昭喜, 中澤徹

日本眼科学会雑誌　116　(臨増)　352-352　2012/03/01
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
マウス網膜神経節細胞障害におけるNrf2の役割

檜森紀子, 中澤徹, 田口恵子, 劉孟林, 安田正幸, 面高宗子, シャナブ・アフメド, 山本雅之

日本眼科学会雑誌　115　(臨増)　252-252　2011/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
軸索流障害による正常眼圧緑内障モデルにおけるカルパイン阻害剤の神経保護効果

安田正幸, 劉孟林, 檜森紀子, 面高宗子, シャナブ・アフメド, 高野二郎, 西道隆臣, 中澤徹

日本眼科学会雑誌　115　(臨増)　253-253　2011/04
Publisher: (公財)日本眼科学会
ISSN： 0029-0203

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Industrial Property Rights 11

眼科解析装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

Property Type: Patent
眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

特許第6186453号

Property Type: Patent
眼科解析装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

特許第6186454号

Property Type: Patent
眼底解析装置及び眼底観察装置

中澤徹, 面高宗子, 松本朗子, 木川勉, 秋葉正博

Property Type: Patent
眼底解析装置及び眼底観察装置

中澤徹, 面高宗子, 松本朗子, 木川勉, 秋葉正博

特許第5937163号

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

Property Type: Patent
眼科解析装置及び眼科撮影装置

中澤徹, 面高宗子, 秋葉正博, 木川勉, 松本朗子

特許第5956518号

Property Type: Patent
視神経障害発症リスクの判定方法

田中佑治, 安田正幸, 面高宗子, 中澤徹

Property Type: Patent

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