TOHOKU UNIVERSITY Researchers - Toshiharu Ichinose

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Toshiharu Ichinose

Section

Frontier Research Institute for Interdisciplinary Sciences

Job title

Associate Professor

Degree

PhD (Tohoku University)

researchmap

https://researchmap.jp/t1nose

J-GLOBAL ID

201801009909487574

Research History 7

2024/04 - Present

Tohoku University　Frontier Research Institute for Interdisciplinary Sciences　Associate Professor
2019/10 - Present

RIKEN　Visiting scientist
2019/04 - 2024/03

Tohoku University　Frontier Research Institute for Interdisciplinary Sciences　Assistant Professor
2017/04 - 2019/03

JSPS Postdoctoral fellow
2016/04 - 2017/03

東北大学大学院　生命科学研究科　研究支援者
2014/04 - 2016/03

JSPS Fellow (DC2)
2012/04 - 2014/03

Deutscher Akademischer Austauschdienst　Long-term fellowship

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Education 4

Tohoku University　Graduate School of Life Sciences

2014/04 - 2015/10
Max Planck Institute of Neurobiology　PhD

2011/05 - 2014/03
The University of Tokyo　Graduate School of Science

2009/04 - 2011/03
The University of Tokyo　Faculty of Science　Department of Biological Sciences

2005/04 - 2009/03

Committee Memberships 3

Frontiers in Neural Circuits　Guest editor

2025/08 - Present
Kasturba Medical College　PhD Co-supervisor

2025/02 - Present
Frontiers Physiology　Editorial Board of Invertebrate Physiology

2021/02 - Present

Research Interests 5

翻訳制御
アルコール
Learning and memory
Drosophila melanogaster
monoamine

Research Areas 3

Life sciences / Molecular biology /
Life sciences / Animals: biochemistry, physiology, behavioral science /
Life sciences / Neuroscience - general / Behavioral genetics

Awards 3

プロミネントリサーチフェロー

2021　東北大学
井上研究奨励賞

2019　井上科学振興財団　嗅覚連合記憶を司るキノコ体外部神経の機能解析
研究科長賞

2016　東北大学生命科学研究科

Papers 22

Ecdysteroid-DopEcR signaling in neuronal and midgut cells mediates toxin avoidance and detoxification in Drosophila Peer-reviewed

Kokoro Saito, Mai Kanno, Hiromu Tanimoto, Toshiharu Ichinose

Current Biology　2025/06/27
Publisher: Elsevier BV
DOI： 10.1016/j.cub.2025.06.023 　
Profiling translation in the nervous system Invited Peer-reviewed

Toshiharu Ichinose, Hiromu Tanimoto

The Journal of Biochemistry　2025/01/02
Publisher: Oxford University Press (OUP)
DOI： 10.1093/jb/mvae096 　

ISSN： 0021-924X

eISSN： 1756-2651

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Abstract Regulation at the level of translation is critical for functions in the nervous system, such as the formation of cell-type specific proteomes or plastic changes in neural circuits. While current knowledge of the translatome is relatively limited compared to transcriptome, a growing array of tools to analyze translation is becoming available. In this review, we introduce techniques for profiling translation on a genome-wide scale with a special emphasis on cell-type specific analyses in the nervous system. This includes polysome-profiling-seq, Translating Ribosome Affinity Purification (TRAP)-seq and ribosome profiling (Ribo-seq). We review recent advances to achieve spatial resolution of translatome analysis, such as genetic labeling of the targeted cells and cell sorting, and discuss the biological implications of translational regulation in the brain and potential future extensions.
Translational regulation enhances distinction of cell types in the nervous system Peer-reviewed

Toshiharu Ichinose, Shu Kondo, Mai Kanno, Yuichi Shichino, Mari Mito, Shintaro Iwasaki, Hiromu Tanimoto

eLife　12　2024/07/16
Publisher: eLife Sciences Publications, Ltd
DOI： 10.7554/elife.90713 　

eISSN： 2050-084X

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Multicellular organisms are composed of specialized cell types with distinct proteomes. While recent advances in single-cell transcriptome analyses have revealed differential expression of mRNAs, cellular diversity in translational profiles remains underinvestigated. By performing RNA-seq and Ribo-seq in genetically defined cells in the Drosophila brain, we here revealed substantial post-transcriptional regulations that augment the cell-type distinctions at the level of protein expression. Specifically, we found that translational efficiency of proteins fundamental to neuronal functions, such as ion channels and neurotransmitter receptors, was maintained low in glia, leading to their preferential translation in neurons. Notably, distribution of ribosome footprints on these mRNAs exhibited a remarkable bias toward the 5′ leaders in glia. Using transgenic reporter strains, we provide evidence that the small upstream open-reading frames in the 5’ leader confer selective translational suppression in glia. Overall, these findings underscore the profound impact of translational regulation in shaping the proteomics for cell-type distinction and provide new insights into the molecular mechanisms driving cell-type diversity.
Mushroom body output differentiates memory processes and distinct memory-guided behaviors International-journal Peer-reviewed

Toshiharu Ichinose, Mai Kanno, Hongyang Wu, Nobuhiro Yamagata, Huan Sun, Ayako Abe, Hiromu Tanimoto

Current Biology　31　(6)　1294-1302　2021/03/22
Publisher: Elsevier BV
DOI： 10.1016/j.cub.2020.12.032 　

ISSN： 0960-9822

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The mushroom body (MB) of Drosophila melanogaster has multiple functions in controlling memory and behavior.1-9 However, circuit mechanisms that generate this functional diversity are largely unclear. Here, we systematically probed the behavioral contribution of each type of MB output neuron (MBON) by blocking during acquisition, retention, or retrieval of reward or punishment memories. We evaluated the contribution using two conditioned responses: memory-guided odor choice and odor source attraction. Quantitative analysis revealed that these conditioned odor responses are controlled by different sets of MBONs. We found that the valence of memory, rather than the transition of memory steps, has a larger impact on the patterns of required MBONs. Moreover, we found that the glutamatergic MBONs forming recurrent circuits commonly contribute to appetitive memory acquisition, suggesting a pivotal role of this circuit motif for reward processing. Our results provide principles how the MB output circuit processes associative memories of different valence and controls distinct memory-guided behaviors.
Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila International-journal Peer-reviewed

Mai Kanno, Shun Hiramatsu, Shu Kondo, Hiromu Tanimoto, Toshiharu Ichinose

Scientific Reports　11　(1)　3432-3432　2021/02/09
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-021-82813-0 　

eISSN： 2045-2322

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<title>Abstract</title>Dysregulated motivation to consume psychoactive substances leads to addictive behaviors that often result in serious health consequences. Understanding the neuronal mechanisms that drive drug consumption is crucial for developing new therapeutic strategies. The fruit fly <italic>Drosophila melanogaster</italic> offers a unique opportunity to approach this problem with a battery of sophisticated neurogenetic tools available, but how they consume these drugs remains largely unknown. Here, we examined drug self-administration behavior of <italic>Drosophila</italic> and the underlying neuronal mechanisms. We measured the preference of flies for five different psychoactive substances using a two-choice feeding assay and monitored its long-term changes. We found that flies show acute preference for ethanol and methamphetamine, but not for cocaine, caffeine or morphine. Repeated intake of ethanol, but not methamphetamine, increased over time. Preference for methamphetamine and the long-term escalation of ethanol preference required the dopamine receptor Dop1R1 in the mushroom body. The protein level of Dop1R1 increased after repeated intake of ethanol, but not methamphetamine, which correlates with the acquired preference. Genetic overexpression of Dop1R1 enhanced ethanol preference. These results reveal a striking diversity of response to individual drugs in the fly and the role of dopamine signaling and its plastic changes in controlling voluntary intake of drugs.
Dopamine receptor Dop1R2 stabilizes appetitive olfactory memory through the Raf/MAPK pathway in Drosophila Peer-reviewed

Huan Sun, Tomoki Nishioka, Shun Hiramatsu, Shu Kondo, Mutsuki Amano, Kozo Kaibuchi, Toshiharu Ichinose, Hiromu Tanimoto

The Journal of Neuroscience　40　2020/04/01
Behavioral Modulation by Spontaneous Activity of Dopamine Neurons. International-journal Peer-reviewed

Toshiharu Ichinose, Hiromu Tanimoto, Nobuhiro Yamagata

Frontiers in systems neuroscience　11　(88)　88-88　2017/12/11

DOI： 10.3389/fnsys.2017.00088 　

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Dopamine modulates a variety of animal behaviors that range from sleep and learning to courtship and aggression. Besides its well-known phasic firing to natural reward, a substantial number of dopamine neurons (DANs) are known to exhibit ongoing intrinsic activity in the absence of an external stimulus. While accumulating evidence points at functional implications for these intrinsic "spontaneous activities" of DANs in cognitive processes, a causal link to behavior and its underlying mechanisms has yet to be elucidated. Recent physiological studies in the model organism Drosophila melanogaster have uncovered that DANs in the fly brain are also spontaneously active, and that this activity reflects the behavioral/internal states of the animal. Strikingly, genetic manipulation of basal DAN activity resulted in behavioral alterations in the fly, providing critical evidence that links spontaneous DAN activity to behavioral states. Furthermore, circuit-level analyses have started to reveal cellular and molecular mechanisms that mediate or regulate spontaneous DAN activity. Through reviewing recent findings in different animals with the major focus on flies, we will discuss potential roles of this physiological phenomenon in directing animal behaviors.
Dynamics of memory-guided choice behavior in Drosophila Peer-reviewed

Toshiharu Ichinose, Hiromu Tanimoto

Proceedings of the Japan Academy, Series B　92　(8)　346-357　2016/10/11

DOI： 10.2183/pjab.92.346 　

ISSN： 0386-2208
Reward signal in a recurrent circuit drives appetitive long-term memory formation Peer-reviewed

Toshiharu Ichinose, Yoshinori Aso, Nobuhiro Yamagata, Ayako Abe, Gerald M. Rubin, Hiromu Tanimoto

eLife　4　(e10719)　2015/11/17

DOI： 10.7554/eLife.10719 　

ISSN： 2050-084X
Neuronal stop-codon readthrough is associated with ribosome pausing and alters protein localization in Drosophila

Toshiharu Ichinose, Koya Sakuma, Hiroto Anbo, Yilin Zhang, Shilin Lu, Cai Xu, Shintaro Iwasaki, Satoshi Fukuchi, Motonori Ota

bioRxiv　2026/07/14
Publisher: openRxiv
DOI： 10.64898/2026.07.13.738141 　

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Abstract Stop-codon readthrough (RT) diversifies proteomes and is particularly prominent in neurons, suggesting its importance in nervous systems. However, the regulatory logic that specifies neuronal RT and the structural and cellular consequences of the resulting C-terminal protein extensions remain poorly understood. Here we leverage neuron-specific ribosome profiling datasets in Drosophila to construct an in vivo atlas of 163 neuronal RT transcripts. Sequence- based modeling distinguished RT from non-RT transcripts and highlighted an extended post-stop region enriched for stable predicted RNA structures. Beyond these cis-associated features, ribosome-footprint analysis revealed pronounced stop-codon pausing on RT transcripts, accompanied by upstream periodic peaks from the stop codon consistent with ribosome queuing. At the protein level, neuronal RT appended polypeptides enriched with polar residues and intrinsically disordered regions (IDRs). Finally, an in vivo dual-color reporter showed that RT of the RNA-binding protein Bru3 alters localization from the nucleus to cytoplasmic granules. Together, our results suggest that neuronal RT is associated with structured post-stop RNA regions that reshape termination dynamics and can produce IDR-rich C-terminal protein extensions with distinct subcellular localization.
Activity-dependent synthesis of translational machinery through dynamic remodeling of ribonucleoprotein granules

Toshiharu Ichinose, Mai Kanno, Takashi Makino, Yuichi Shichino, Shintaro Iwasaki, Hiromu Tanimoto

bioRxiv　2026/07/02
Publisher: openRxiv
DOI： 10.64898/2026.06.28.734671 　

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Abstract Neuronal stimulation drives gene-expression programs supporting long-lasting changes, yet how depolarization reshapes post-transcriptional regulation remains poorly understood. Here, we combined optogenetic stimulation with neuron-specific Ribo-seq and RNA-seq in the Drosophila brain to resolve activity-evoked translational dynamics. Stimulation triggered two temporally ordered programs: a rapid wave to translate synapse remodeling factors and neuropeptides, followed by a dominant delayed program that selectively upregulated translation of protein synthesis machinery, including nearly all cytosolic ribosomal proteins (RPs). Transcripts in the late program are marked by 5’ terminal oligopyrimidine (TOP) motifs. TOP mRNAs accumulated in ribonucleoprotein granules at the basal state but are released upon stimulation. We identified La-related protein as a key regulator of the activity-dependent translation of TOP mRNA and memory consolidation. Comparative genomics indicated that TOP enrichment in RP mRNAs is specific to metazoans. These findings suggest that animals acquired activity-dependent TOP-mRNA control to couple neuronal stimulation with adaptation of translational capacity.
Presynaptic computation of reward intensities through the dual autoreceptor system Peer-reviewed

Kokoro Saito, Shun Hiramatsu, Aoi Watanabe, Hongyang Wu, Toshiharu Ichinose, Nobuhiro Yamagata, Hiromu Tanimoto

Current Biology　2026/04/23
Publisher: Elsevier BV
DOI： 10.1016/j.cub.2026.03.077 　

ISSN： 0960-9822
Chameau (HBO1) regulates starvation resistance in Drosophila melanogaster in a temperature-dependent manner Peer-reviewed

Anuroop Venkateswaran Venkatasubramani, Toshiharu Ichinose, Ignasi Forne, Nathaniel W Snyder, Hiromu Tanimoto, Shahaf Peleg, Axel Imhof

Life Science Alliance　9　(1)　e202503524-e202503524　2026/01
Publisher: Life Science Alliance, LLC
DOI： 10.26508/lsa.202503524 　

eISSN： 2575-1077

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The body temperature of Drosophila melanogaster depends on the extrinsic temperature. Numerous studies show that environmental temperature influences metabolism, lifespan, and starvation resilience. We have previously shown that Chameau (Chm), a MYST-domain acetyltransferase, promotes aging but also increases starvation resilience. Strikingly, the metabolic increase associated with a 2°C temperature rise was sufficient to bypass the requirement for Chm in starvation resilience, suggesting that Chm modulates metabolism in a temperature-dependent manner. The increase in temperature also rescued the dampened expression of genes involved in starvation response, the weight loss, and the misregulation of trehalose, which we observed in chm mutants at 23°C. Thus, Chm regulates starvation at ≤23°C but becomes obsolete at higher temperatures, likely because of efficient acetyl-CoA generation ensuring similar acetylation despite lower Chm. Supporting this, citrate supplementation increased starvation resilience of chm mutants at lower temperatures. Our finding that a gene’s role manifests only under specific environments has important implications in light of global climate change.
Translational control in the nervous system: A ribosome profiling approach Invited Peer-reviewed

Toshiharu Ichinose

The Japan Society for Comparative Physiology and Biochemistry　42　(3)　152-157　2025/12/11

DOI： 10.3330/hikakuseiriseika.42.152 　
An Innate Immune Receptor Toll-1 converts chronic light stress into glial-phagocytosis

Jiro Osaka, Toshiharu Ichinose, Mai Kanno, Satoko Hakeda-Suzuki, Takashi Suzuki, Atsushi Sugie

bioRxiv　2025/09/08
Publisher: Cold Spring Harbor Laboratory
DOI： 10.1101/2025.09.03.673940 　

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SUMMARY Chronic stress can cause progressive neuronal degeneration, yet the molecular mechanisms linking stress sensing to neuroimmune responses remain elusive. In this study, a Drosophila model of chronic light-induced stress, we show that photoreceptor neurons accumulate reactive oxygen species (ROS) and exhibit Toll-1 activation, in association with Spätzle ligands and receptor endocytosis. Toll-1 activation in neurons promotes axonal degeneration by inducing expression of the glial phagocytic receptor Draper (Drpr), leading to the engulfment of stressed axons. Genetic interaction analyses indicate that Toll-1 functions upstream of Drpr in a stress-responsive signaling cascade. Importantly, blocking either Toll-1 or Drpr attenuates axon loss under light stress, highlighting their essential roles. Our findings reveal a neuron-glia communication axis in which neuronal innate immune signaling instructs glial phagocytosis, converting sustained environmental stress into structural degeneration. This study provides a mechanistic framework for sterile neurodegeneration and offers insights into how immune receptors regulate nervous system integrity under non-infectious conditions.
Gut microbiota–mediated lipid accumulation as a driver of evolutionary adaptation to blue light toxicity in Drosophila Peer-reviewed

Yuta Takada, Toshiharu Ichinose, Naoyuki Fuse, Kokoro Saito, Wakako Ikeda-Ohtsubo, Hiromu Tanimoto, Masatoshi Hori

Communications Biology　8　(1)　2025/07/07
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s42003-025-08348-6 　

eISSN： 2399-3642
Peer-induced quiescence of male Drosophila melanogaster following copulation Peer-reviewed

Katrina Lynn, Toshiharu Ichinose, Hiromu Tanimoto

Frontiers in Behavioral Neuroscience　18　2024/07/16
Publisher: Frontiers Media SA
DOI： 10.3389/fnbeh.2024.1414029 　

eISSN： 1662-5153

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Mating experience impacts the physiology and behavior of animals. Although mating effects of female Drosophila melanogaster have been studied extensively, the behavioral changes of males following copulation have not been fully understood. In this study, we characterized the mating-dependent behavioral changes of male flies, especially focusing on fly-to-fly interaction, and their dependence on rearing conditions. Our data demonstrate that male flies quiesce their courtship toward both females and males, as well as their locomotor activity. This post-copulatory quiescence appears to be contingent upon the presence of a peer, as minimal variation is noted in locomotion when the male is measured in isolation. Interestingly, copulated males influence a paired male without successful copulation to reduce his locomotion. Our findings point to a conditional behavioral quiescence following copulation, influenced by the presence of other flies.
The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity Peer-reviewed

Anuroop Venkatasubramani, Toshiharu Ichinose, Mai Kanno, Ignasi Forne, Hiromu Tanimoto, Shahaf Peleg, Axel Imhof

EMBO reports　24　(10)　2023/09/19
Publisher: Springer Science and Business Media LLC
DOI： 10.15252/embr.202357023 　

ISSN： 1469-221X

eISSN： 1469-3178

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Abstract Proteins involved in cellular metabolism and molecular regulation can extend lifespan of various organisms in the laboratory. However, any improvement in aging would only provide an evolutionary benefit if the organisms were able to survive under non‐ideal conditions. We have previously shown that Drosophila melanogaster carrying a loss‐of‐function allele of the acetyltransferase chameau (chm) has an increased healthy lifespan when fed ad libitum. Here, we show that loss of chm and reduction in its activity results in a substantial reduction in weight and a decrease in starvation resistance. This phenotype is caused by failure to properly regulate the genes and proteins required for energy storage and expenditure. The previously observed increase in survival time thus comes with the inability to prepare for and cope with nutrient stress. As the ability to survive in environments with restricted food availability is likely a stronger evolutionary driver than the ability to live a long life, chm is still present in the organism's genome despite its apparent negative effect on lifespan.
Spontaneous activity of dopamine neurons and its role in behavioral regulation Peer-reviewed

Hikaku-Seiri-Seikagaku　34　108-115　2017/12/28

DOI： 10.3330/hikakuseiriseika.34.108 　
Direct neural pathways convey distinct visual information to Drosophila mushroom bodies Peer-reviewed

Katrin Vogt, Yoshinori Aso, Toshihide Hige, Stephan Knapek, Toshiharu Ichinose, Anja B. Friedrich, Glenn C. Turner, Gerald M. Rubin, Hiromu Tanimoto

eLife　5　(e14009)　2016/04/15

DOI： 10.7554/eLife.14009 　

ISSN： 2050-084X
Distinct dopamine neurons mediate reward signals for short- and long-term memories Peer-reviewed

Nobuhiro Yamagata, Toshiharu Ichinose, Yoshinori Aso, Pierre-Yves Placais, Anja B. Friedrich, Richard J. Sima, Thomas Preat, Gerald M. Rubin, Hiromu Tanimoto

Proceedings of the National Academy of Sciences of the United States of America　112　(2)　578-583　2015/01/13

DOI： 10.1073/pnas.1421930112 　

ISSN： 0027-8424
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila Peer-reviewed

Yoshinori Aso, Divya Sitaraman, Toshiharu Ichinose, Karla R. Kaun, Katrin Vogt, Ghislain Belliart-Guerin, Pierre-Yves Placais, Alice A. Robie, Nobuhiro Yamagata, Christopher Schnaitmann, William J. Rowell, Rebecca M. Johnston, Teri-T B. Ngo, Nan Chen, Wyatt Korff, Michael N. Nitabach, Ulrike Heberlein, Thomas Preat, Kristin M. Branson, Hiromu Tanimoto, Gerald M. Rubin

eLife　3　(e04580)　2014/12/23

DOI： 10.7554/eLife.04580 　

ISSN： 2050-084X

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Misc. 4

神経系におけるトランスラトームアトラス Invited

市之瀬敏晴

上原記念生命科学財団研究報告書　38　B25　2025/02
ショウジョウバエの神経回路に学ぶ効率の良い学習 Invited

市之瀬敏晴

リバネス「研究応援」　29　2023/03
ショウジョウバエに学ぶ飲酒の脳内メカニズム Invited

市之瀬敏晴

Medical Science Digest　2022/03
飲酒量はなぜ増える？―ショウジョウバエから探る神経メカニズム Invited

市之瀬敏晴

バイオサイエンスとインダストリー　79　(5)　2021/09

Presentations 46

神経系における時空間の細胞多様性を駆動する翻訳制御メカニズム Invited

市之瀬敏晴

第４回創発の場　2026/06/17
Cell-type specific translation in the Drosophila nervous system Invited

Toshiharu Ichinose

The 59th Annual Meeting of The Japanese Society of Developmental Biologists　2026/06/09
Activity-dependent synthesis of translational machineries through dynamic remodeling of ribonucleoprotein granules

Toshiharu Ichinose

Asia Pacific Drosophila Neurobiology Conference 4　2026/04/21
Translational mechanisms for impaired sleep rhythm after chronic malnutrition Invited

Toshiharu Ichinose

Chronoproteinnology grant meeting　2026/01/10
Molecular mechanisms of differential translation among neuronal and glial cells International-presentation

Yingyue Fang, Hiromu Tanimoto, Toshiharu Ichinose

Asia Pacific Drosophila Research Conference 7　2025/12/02
Translatome approach to memory stability and sleep rhythm Invited

Toshiharu Ichinose

Japanese Society for Chronobiology　2025/10/05
細胞種特異的トランスラトーム解析から解明する脳のタンパク質翻訳制御 Invited

Toshiharu Ichinose

the 96th Annual Meeting of Zoological Society of Japan　2025/09/04
Functions of polypeptides encoded in ‘untranslated regions’

Toshiharu Ichinose

15th Workshop for Molecular Analysis of Higher Brain Function　2025/08/22
Stop Codon Readthrough alters subcellular localization of proteins in the Nervous System of Drosophila. International-presentation

Shilin Lu, Toshiharu Ichinose

Annual meeting for Japan RNA Society　2025/07/10
Molecular mechanisms of differential protein synthesis among cell types International-presentation

Yingyue Fang, Hiromu Tanimoto, Toshiharu Ichinose

Japan RNA Society　2025/07/09
Activity-dependent translation in the brain Invited

Toshiharu Ichinose

2025/06/09
慢性飢餓ストレスが引き起こす睡眠リズム障害の翻訳メカニズム Invited

市之瀬敏晴

時間タンパク質学・第３回領域会議　2025/04/16
Immediate early translation following neuronal activity International-presentation Invited

Toshiharu Ichinose

Taiwan-Japan Drosophila Joint meeting, National Health Research Institute, Zhunan, Taiwan　2024/11/14
Molecular mechanisms underlying the untranslated region（UTR）- mediated differential translational regulation in neurons and glia International-presentation

Fang Y., Tanimoto H., Ichinose T.

The 16th Japanese Drosophila Research Conference　2024/09/18
Cell type distinction and neuronal adaptation through translational regulation International-presentation Invited

Toshiharu Ichinose

The 46th annual meeting of the Japan Neuroscience Society, Symposium "Understanding neurodevelopment and plasticity through the lens of intracellular machineries"　2024/07/26
Translational regulation for cell type distinction and neuronal adaptation in the Drosophila brain

Toshiharu Ichinose

RNA Society Japan　2024/06/28
Cell type differentiation and adaptation through translational regulations in the Drosophila brain International-presentation Invited

Toshiharu Ichinose

Insect Neuroscience Symposium, Nagoya Univ　2024/05/07
Translational regulations for cell type distinction and neuronal adaptation International-presentation

Toshiharu Ichinose

The Asia Pacific Drosophila Neurobiology Conference 3　2024/02/27
Profiling translation in the brain Invited

Toshiharu Ichinose

Lecture series in Adaptive Circuit Census　2024/01/22
A novel role of Ecdysone-DopEcR signaling in toxin aversion and addiction-like behavior International-presentation

Saito K, Watanabe A, Tanimoto H, Ichinose T

The 46th annual meeting of the Japan Neuroscience Society　2023/08/03
How cellular diversity and neuronal plasticity formed in the brain?: from the perspective of translational regulations International-presentation Invited

Toshiharu Ichinose

Tohoku initiative for NeuroTech Innovations, Tohoku Univ　2023/07/31
Translational control in the brain: understanding cellular diversity and plasticity International-presentation Invited

Toshiharu Ichinose

183th WPI-IIIS seminar, Tsukuba Univ　2023/07/27
Translational regulation enhances distinction of cell types in the nervous system International-presentation Invited

Toshiharu Ichinose

Neural Circuits and Behavior of Drosophila Workshop, Crete, Greece　2023/05/28
Visualization of stop-codon readthrough Invited

Toshiharu Ichinose

Meeting in multi-faceted proteins　2022/12/07
Protein translation in the fly brain Invited

RIKEN workshop　2022/11/29
Translation dynamics in memory-encoding circuit Invited

Toshiharu Ichinose

2022/11/04
Translational regulation through upstream ORF enhances cell-type specific expression of neuronal proteins

Ichinose T, Kondo S, Kanno M, Shichino Y, Mito M, Iwasaki S, Tanimoto H

The 15th Japan Drosophila Research Conference　2022/09/14
ストップコドンリードスルーを引き起こすリボソーム渋滞 Invited

市之瀬敏晴

マルチファセットプロテインズ第二回領域会議　2022/03/14
In vivo stop codon readthrough Invited

2021/10/29
記憶の形成・固定化メカニズム Invited

市之瀬敏晴

東北大学生命科学交流ミーティング　2021/09/21
多様な記憶の形成・固定化・読み出しメカニズム Invited

市之瀬敏晴

生理学研究所研究会2021 記憶・学習の多角的理解に向けたアプローチ　2021/09/16
Translation dynamics upon memory-inducing neuronal stimuli Invited

Toshiharu Ichinose, Yuichi Shichino

Kick-Off Workshop 2021 on RIKEN-Tohoku Univ Sci&Tech Hub Collab　2021/07/06
Decoding distinct memories in the mushroom body of the fly brain International-presentation

市之瀬敏晴

Neurobiology of Drosophila, Cold Spring Harbor Laboratory, USA　2019/10/01
Decoding distinct memories in the mushroom body of the fly brain International-presentation Invited

市之瀬敏晴

公開セミナー、Harvard University　2019/09/29
The 42th Annual Meeting of the Japan Neuroscience Society International-presentation

Toshiharu Ichinose

2019/07/29
Research experience in Germany International-presentation Invited

市之瀬敏晴

公開セミナー、”Enhance your international network in Germany”　2019/06/14
Research in Germany Invited

市之瀬敏晴

公開セミナー、PhD and Postdoc Consultations at the European Higher Education Fair (EHEF)　2019/05/21
Chronic poor condition enhances preference for rewarding substances through dopamine system International-presentation

市之瀬敏晴

Asia-pacific Drosophila neurobiology conference, Taipei, Taiwan　2019/01/16
Chronic poor condition enhances preference for rewarding substances International-presentation

Toshiharu Ichinose

‘13th Japanese Drosophila Research Conference’, Kyoto, Japan　2018
Neural circuits that distinguish memory processes in the fly brain International-presentation

Toshiharu Ichinose

‘4th Asia pacific Drosophila research conference’, Osaka, Japan　2017
Decoding distinct memories in the fly brain International-presentation

Toshiharu Ichinose

‘15th European symposium for insect taste and olfaction’, Villasimius, Italy　2017
The mushroom body extrinsic neurons for associative memory Invited

市之瀬敏晴

新潟大学超域学術院セミナー　2017
Plastic behavior of flies: Learning and addiction Invited

市之瀬敏晴

東北大学生命科学研究科若手交流ミーティング　2016
Neuronal circuits for appetitive long-term memory” International-presentation Invited

Toshiharu Ichinose

Seminar in Brown University, USA　2014
Regulation of the reward signal to drive appetitive LTM formation International-presentation

Toshiharu Ichinose

‘The 2nd Taiwan-Tohoku University Neuroscience Workshop for Young Scientists’, Miyagi, Japan　2014
Reward signal in a recurrent circuit drives appetitive long-term memory formation International-presentation

Toshiharu Ichinose

‘Learning and memory: A Synthesis of Bees and Flies’, Janelia Research Campus, Ashburn, USA　2014

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Research Projects 21

Translatome mechanisms driving spatial and temporal cellular diversity in the nervous system

Toshiharu Ichinose

Offer Organization: JST

System: FOREST

Institution: Tohoku University

2025/10 - 2032/09
学習後の翻訳初期応答の機能解明

市之瀬敏晴, 近藤周

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2026/04 - 2030/03
相反する記憶を駆動する翻訳メカニズムの解明

谷本拓, 岩崎信太郎, 近藤周, 市之瀬敏晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(A)

Institution: 東北大学

2025/04/01 - 2028/03/31
臨界期の貧栄養ストレスによる薬物乱用リスクの解明

市之瀬敏晴

Offer Organization: 公益財団法人ロッテ財団

System: 奨励研究助成

2025/04 - 2028/03
Cell-type specific transcriptional and translational mechanisms involved in social isolation stress in Drosophila

2025/06 - 2027/05
Physiological function of polypeptide encoded in ′untranslated′ regions

Toshiharu Ichinose, Nobuhiro Yamagata

2025/06 - 2027/03
慢性飢餓ストレスが引き起こす睡眠リズム障害の翻訳メカニズム

市之瀬敏晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 学術変革領域研究(A)

Institution: 東北大学

2025/04 - 2027/03
Translatome responses to extreme sleep rhythms and neuronal integration

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Institution: Tohoku University

2022/10 - 2026/03
神経系におけるトランスラトームアトラス

市之瀬敏晴

Offer Organization: 上原記念生命科学財団

System: 研究奨励金

Institution: 東北大学

2023/04 - 2024/03
Molecular mechanism for memory consolidation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04 - 2024/03
記憶回路における翻訳ダイナミクス

市之瀬敏晴、七野悠一

Offer Organization: 理研-東北大共同研究プログラム

Institution: 東北大学

2022/04 - 2023/03
Stop codon readthrough in vivo

Offer Organization: Japan Society for the Promotion of Science

System: Grant-in-Aid for Transformative Research Areas (A)

Institution: Tohoku University

2021/10 - 2023/03
TOR-4EBPを介した神経活動依存的な翻訳ダイナミクスの解明

市之瀬敏晴

Offer Organization: 武田科学振興財団

System: ライフサイエンス研究助成

Institution: 東北大学

2021/08 - 2023/03
学習依存的に合成されるタンパク質の同定と記憶の長期化における動態の解明

谷本拓, 近藤周, 市之瀬敏晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(A)

Category: 基盤研究(A)

Institution: 東北大学

2020/04 - 2023/03
学習刺激に応答する翻訳ダイナミクス

市之瀬敏晴, 七野悠一

Offer Organization: 理研-東北大共同研究プログラム

2021/04 - 2022/03
脳内の神経伝達物質の放出を計測する電気化学高分子プローブ

阿部博弥, 市之瀬敏晴, 郭媛元

Offer Organization: 東北大学学際科学フロンティア研究所

System: 学際研究共創プログラム

2020/04 - 2022/03
経験が報酬刺激物質に対する嗜好性を変化させる機構の解明 Competitive

市之瀬敏晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業若手研究

2019/04 - 2021/03
薬物依存症のシナプスメカニズム Competitive

市之瀬敏晴

Offer Organization: 日本学術振興会

System: 特別研究員奨励費（PD）

2017/04 - 2019/03
短期から長期記憶への神経回路の変遷 Competitive

市之瀬敏晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業若手研究（B）

2016/04 - 2019/03
Neural circuits that distinguish memory processes in the fly brain

Tanimoto Hiromu, YAMAGATA Nobuhiro, ICHINOSE Toshiharu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2017/03/31

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Fruit flies Drosophila melanogaster bidirectionally adapt the response to an odor based on appetitive and aversive memories of sugar reward and electric shock punishment, respectively. Accumulating evidence suggest that the output from a brain structure called the mushroom body (MB) is necessary for acquisition, consolidation, and retrieval of appetitive and aversive memories. However, it is largely unclear how the common MB circuit operates these distinct memory processes. To comprehensively characterize the organization of the MB output, we anatomically identified all the MB output neuron types in Drosophila. By measuring the behavioral importance of each output pathway, we found that the different sets of the MB output neurons are recruited in appetitive and aversive memories. Furthermore, our comprehensive behavioral analysis revealed acquisition, consolidation and retrieval of memories are characterized by the combinatorial functions of MB output neurons.
ショウジョウバエ記憶中枢における記憶に必要な神経細胞種の全同定 Competitive

市之瀬敏晴

Offer Organization: 日本学術振興会

System: 特別研究員奨励費（DC2）

2014/04 - 2016/03

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Teaching Experience 5

Biology B　Tohoku University
Biology A　Tohoku University
行動遺伝学　東北大学理学部
Special Lectures on Ecology and Evolutionary Biology I　Tohoku University
Animal physiology　Tohoku University

Social Activities 4

10th FRIS/DIARE Joint Workshop

2025/08/06 -
研究者になるってどんな感じ？ - 世界を変える仕事への旅人-

2024/05/26 -
NeuroTech Art Exhibition

2023/07/31 -
片平まつり

2021/10/09 -

Media Coverage 3

Miyagi Tele-Masa

NHK

2024/12/24

Type: TV or radio program
あしたが変わるトリセツショー「お酒」のトリセツ

NHK

2024/12/12

Type: TV or radio program
“飲兵衛”はドーパミン受容体が増える酒量増の仕組み解明

Science Portal　マイナビニュース

2021/03/03

Type: Internet

Academic Activities 1

Tohoku initiative for NeuroTech Innovations

2023/07/31 -

Activity type: Competition, symposium, etc.