Details of the Researcher

PHOTO

Yoshifumi Saijo
Section
Graduate School of Biomedical Engineering
Job title
Professor
Degree

  • 博士（医学）（東北大学）

Education 2

  • Tohoku University　Graduate School of Medicine

    - 1993/03

  • Tohoku University　School of Medicine

    - 1988/03

Committee Memberships 4

  • 一般社団法人 東北臨床研究審査機構 共同臨床研究審査委員会　委員長

    2018/04 - Present

  • 一般財団法人公正研究推進協会（APRIN）　中等教育教材作成分科会 委員

    2017/11 - Present

  • 公益社団法人日本超音波医学会　代議員

    2006/05 - Present

  • 一般社団法人 日本心エコー図学会　代議員

    2003/10 - Present

Professional Memberships 3

  • The Japan Society of Ultrasonics in Medicine(2006/05-2008/05 )

  • 日本栓子検出と治療学会(2002/10- 世話人)

  • 日本心エコー図学会(2003/10- 評議員)

Research Interests 3

  • cardiology

  • medical ultrasound

  • Biomedical imaging

Research Areas 4

  • Life sciences / Biomaterials / Biomedical Engineering

  • Life sciences / Biomedical engineering / Biomedical Engineering

  • Life sciences / Cardiology / Cardiology

  • Life sciences / Medical systems /

Awards 9

  1. Clinical Prize 1997

    1998/01　World Federation for Ultrasound in Medicine and Biology　Ultrasonic tissue characterization of infarcted myocardium by scanning acoustic microscopy

  2. Symposium on Ultrasonic Electronics 2021: Best Paper Award

    2022/11　Symposium on Ultrasonic Electronics　Comparative investigation of coherence factor weighting methods for an annular array photoacoustic microscope

  3. Symposium on Ultrasonic Electronics 2019: Best Paper Award

    2020/11　Symposium on Ultrasonic Electronics　Development of optical resolution photoacoustic microscopy with sub-micron lateral resolution for visualization of cells and their structures

  4. The 15th Ito Award

    2020/05　Role of intra-ventricular vortex in left ventricular ejection elucidated by echo-dynamography.

  5. Symposium on Ultrasonic Electronics 2017: Best Paper Award

    2018/11　Symposium on Ultrasonic Electronics　Singular value decomposition of received ultrasound signal to separate tissue, blood flow, and cavitation signals

  6. Korea Artificial Organ Center Award

    2006/08/28　Korea Artificial Organ Center　Evaluation of Cardiac Function of the Patients with Left Ventricular Assist Device by Transesophageal Echocardiography

  7. The CCT 2004 Award for Excellence

    2004/10/21　CCT　Ultrasonic tissue characterization of flow limiting thrombus in acute myocardial infarction by acoustic microscopy.

  8. Outstanding Paper Award: 2003 Northern Region Congress of Asia Pacific Orthopaedic Association.

    2003/12/05　アジア太平洋整形外科学会

  9. Best Poster Award , 13th Roterdam Conference on Echocardiology

    1999/06/23　ロッテルダム心エコー学会

Show all ︎Show 5

Papers 475

  1. A Deep-Learning-Aided Diagnosis of Drowning using Post-mortem Lung Computed Tomography Peer-reviewed

    Amber Habib Qureshi, Takuro Ishii, Yoshifumi Saijo

    Forensic Imaging　200629-200629　2025/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.fri.2025.200629 　

    ISSN： 2666-2256

  2. Image quality improvement in single plane-wave imaging using deep learning

    Kanta Miura, Hiromi Shidara, Takuro Ishii, Koichi Ito, Takafumi Aoki, Yoshifumi Saijo, Jun Ohmiya

    Ultrasonics　145　107479-107479　2025/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.ultras.2024.107479 　

    ISSN： 0041-624X

  3. Human body temperature and cardiovascular response to changes in ambient temperature and body posture Peer-reviewed

    Tomonobu Goto, Zhuoxi Niu, Yuki Chiba, Kentaro Amano, Yoshifumi Saijo

    Building and Environment　2024/12

    DOI： 10.1016/j.buildenv.2024.112085 　

  4. Trends and Developments in 3D Photoacoustic Imaging Systems: A Review of Recent Progress

    Fikhri Astina Tasmara, Mitrayana Mitrayana, Andreas Setiawan, Takuro Ishii, Yoshifumi Saijo, Rini Widyaningrum

    Medical Engineering & Physics　104268-104268　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.medengphy.2024.104268 　

    ISSN： 1350-4533

  5. Singular value decomposition with weighting matrix applied for optical-resolution photoacoustic microscopes

    I Gede Eka Sulistyawan, Daisuke Nishimae, Takuro Ishii, Yoshifumi Saijo

    Ultrasonics　143　107424-107424　2024/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.ultras.2024.107424 　

    ISSN： 0041-624X

  6. Testbed mimicking intracellular environment for optical-resolution photoacoustic microscopy

    Daisuke Nishimae, Takuro Ishii, Koetsu Ogasawara, Yoshifumi Saijo

    Japanese Journal of Applied Physics　2024/03/25

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/ad3761 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    Abstract Photoacoustic imaging (PAI) represents an innovative method that utilizes optics for transmission and acoustic for sensing. Within the realm of PAI modalities, optical-resolution photoacoustic microscopy (OR-PAM) stands out for its ability to achieve high-resolution cellular and intracellular imaging. However, an optical testbed setup emulating the intracellular environment and accelerating the development of cellular-level OR-PAM systems has not been established. In this study, we present a testbed setup designed to mimic intracellular conditions. Assessment of this testbed setup efficacy involved embedding photoacoustic contrasts and imaging them using an OR-PAM system. The imaging results show that our testbed setup can provide instrumental in accurately measuring photoacoustic signals within an intracellular aqueous environment, avoiding risks of the contamination and degradation of the acoustic transducer.

  7. Effects of diameter of optical absorber visualized by an annular array AR-PAM system on spectrum characteristics of photoacoustic signals

    Riku Suzuki, I Gede Eka Sulistyawan, Takuro Ishii, Yoshifumi Saijo

    Japanese Journal of Applied Physics　2024/03/21

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/ad3650 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    Abstract Spectrum characteristics of photoacoustic signals are potential indicators to assess the structural information of optical absorbers. This study investigated whether a spectrum analysis approach can evaluate microvascular diameters obtained by an annular array AR-PAM system. First, 2D numerical simulations were performed to estimate spectral changes in five absorbers with different diameters from 30 µm to 200 µm. Slope and intercept values from the regression line of the spectrum curve were calculated. Second, the estimated changes were validated by acquiring photoacoustic signals from tungsten wires with five different diameters. Both in numerically and experimentally, spectrum analysis showed the larger the diameter, the greater the lower frequency components, resulting in steeper slope and greater intercept values. Finally, photoacoustic signals acquired from cutaneous microvessels were analyzed. The FWHM diameter of the vessels were corresponded to the slope (r= -0.595; p< 0.05) and intercept (r= 0.657; p< 0.05) values, respectively.

  8. Blood Pressure Estimation from Photoplythmography Using Hybrid Scattering–LSTM Networks

    Osama A. Omer, Mostafa Salah, Ammar M. Hassan, Mohamed Abdel-Nasser, Norihiro Sugita, Yoshifumi Saijo

    BioMedInformatics　4　(1)　139-157　2024/01/09

    Publisher: MDPI AG

    DOI： 10.3390/biomedinformatics4010010 　

    eISSN： 2673-7426

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    One of the most significant indicators of heart and cardiovascular health is blood pressure (BP). Blood pressure (BP) has gained great attention in the last decade. Uncontrolled high blood pressure increases the risk of serious health problems, including heart attack and stroke. Recently, machine/deep learning has been leveraged for learning a BP from photoplethysmography (PPG) signals. Hence, continuous BP monitoring can be introduced, based on simple wearable contact sensors or even remotely sensed from a proper camera away from the clinical setup. However, the available training dataset imposes many limitations besides the other difficulties related to the PPG time series as high-dimensional data. This work presents beat-by-beat continuous PPG-based BP monitoring while accounting for the aforementioned limitations. For a better exploration of beats’ features, we propose to use wavelet scattering transform as a better descriptive domain to cope with the limitation of the training dataset and to help the deep learning network accurately learn the relationship between the morphological shapes of PPG beats and the BP. A long short-term memory (LSTM) network is utilized to demonstrate the superiority of the wavelet scattering transform over other domains. The learning scenarios are carried out on a beat basis where the input corresponding PPG beat is used for predicting BP in two scenarios; (1) Beat-by-beat arterial blood pressure (ABP) estimation, and (2) Beat-by-beat estimation of the systolic and diastolic blood pressure values. Different transformations are used to extract the features of the PPG beats in different domains including time, discrete cosine transform (DCT), discrete wavelet transform (DWT), and wavelet scattering transform (WST) domains. The simulation results show that using the WST domain outperforms the other domains in the sense of root mean square error (RMSE) and mean absolute error (MAE) for both of the suggested two scenarios.

  9. Superficial Bifurcated Microflow Phantom for High-Frequency Ultrasound Applications

    Anam Bhatti, Takuro Ishii, Yoshifumi Saijo

    Ultrasound in Medicine & Biology　50　(1)　158-164　2024/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.ultrasmedbio.2023.10.002 　

    ISSN： 0301-5629

  10. 超音波Bモード画像のテンプレートマッチングによる嚥下運動解析法の検討

    川上 紗弥香, 澤田 朱里, 太田 淳, 石井 琢郎, 香取 幸夫, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　123　(214)　19-23　2023/10

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  11. Ultrasound vector flow imaging during veno-arterial extracorporeal membrane oxygenation in a thoracic aorta model

    Kenichiro Yambe, Takuro Ishii, Billy Y. S. Yiu, Alfred C. H. Yu, Tomoyuki Endo, Yoshifumi Saijo

    Journal of Artificial Organs　2023/07/20

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10047-023-01413-z 　

    ISSN： 1434-7229

    eISSN： 1619-0904

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    Abstract In veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment, the mixing zone is a key hemodynamic factor that determines the efficacy of the treatment. This study aimed to evaluate the applicability of a novel ultrasound technique called vector flow imaging (VFI) for visualizing complex flow patterns in an aorta phantom under VA-ECMO settings. VFI experiments were performed to image aortic hemodynamics under VA-ECMO treatment simulated in an anthropomorphic thoracic aorta phantom using a pulsatile pump (cardiac output: 2.7 L/min) and an ECMO pump with two different flow rates, 0.35 L/min and 1.0 L/min. The cardiac cycle of hemodynamics in the ascending aorta, aortic arch, and descending aorta was visualized, and the spatio-temporal dynamics of flow vectors were analyzed. VFI successfully visualized dynamic flow patterns in the aorta phantom. When the flow rate of the ECMO pump increased, ECMO flow was more dominant than cardiac output in the diastole phase, and the speed of cardiac output was suppressed in the systole phase. Vortex flow patterns were also detected in the ascending aorta and the arch under both ECMO flow rate conditions. The VFI technique may provide new insights into aortic hemodynamics and facilitates effective and safe VA-ECMO treatment.

  12. Evaluation of temperature-dependent fluctuations in skin microcirculation flow using a light-emitting diode based photoacoustic imaging device

    Yosuke Ito, Takuro Ishii, Shin Yamazaki, Akiko Yoshida, Kei Nagaya, Yoshifumi Saijo

    Journal of Clinical Monitoring and Computing　2023/05/11

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s10877-023-01026-0 　

    ISSN： 1387-1307

    eISSN： 1573-2614

  13. Ultrasound flow phantom for transcranial Doppler: An assessment of angular mismatch effect on blood velocity measurement in comparison to optical particle image velocimetry

    Muhammad Shiddiq Sayyid Hashuro, Kotaro Daibo, Takuro Ishii, Yoshifumi Saijo, Makoto Ohta

    Frontiers in Physics　11　2023/04/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fphy.2023.1134588 　

    eISSN： 2296-424X

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    Detecting abnormal blood flow is possible through transcranial Doppler (TCD) ultrasound by measuring blood velocity in cerebral arteries. Velocity measurements are at the highest precision when the direction of blood flow coincides with the ultrasound beam. However, because TCD is typically performed blindly (i.e., without a B-mode), a 0° interrogation angle is usually assumed. This leads to a common issue of angular mismatch. This study quantitatively shows the angular mismatch effects on the measured velocities using a TCD ultrasound flow phantom compared with the velocities measured by optical particle image velocimetry (PIV) as control. Resulting errors with and without ultrasound machine angular correction were also considered. An ultrasound phantom developed by combining polyvinyl alcohol hydrogel (PVA-H), quartz glass as a scatterer, and a gypsum plate as a skull bone was utilized to approximate the middle cerebral artery TCD measurement from the temporal window. The PVA-H and quartz glass compositions were controlled to achieve transparency and enable PIV velocity measurement. Then, TCD velocity measurement was conducted on several interrogation and mismatch angles. Comparison results revealed that without an ultrasound machine angle correction, all measurements yielded underestimation with 73.9% at the highest in the 80° interrogation window at the 130 mL/min flow. On the other hand, with the correction, the errors in almost all angles were comparatively lower; however, at 80° at the 124 mL/min flow, a maximum overestimation rate of 113.7% was found, showing a larger error magnitude. Therefore, we find that angular mismatch, especially in larger angles, leads to inaccurate velocity measurements in TCD. Our results suggest that despite angle correction, velocity errors may still occur when the interrogation angle changes.

  14. A study on correction method of total acoustic power in presence of shielding in focused ultrasound treatment using acoustic radiation force imaging

    Erika Numahata, Shin YOSHIZAWA, Shin-ichiro UMEMURA, Takuro Ishii, Yoshifumi Saijo

    Japanese Journal of Applied Physics　2023/03/20

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/acc595 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    Abstract High-intensity focused ultrasound (HIFU) therapy is a noninvasive treatment for cancer. Prediction of the HIFU treatment region in advance by ultrasound imaging is important for the efficacy and safety of the treatment. Acoustic radiation force (ARF) imaging has been shown to be useful in estimating the heat distribution caused by HIFU. In this study, we investigated the effect of shielding on the estimated heat distribution when the propagation of HIFU is partially shielded by an object simulating ribs, imitating an actual clinical situation, and examined the correction method of HIFU output power using ARF imaging to obtain tissue coagulation equivalent to that without shielding. As a result, it was suggested that even with partial acoustic shielding, when the HIFU output power is adjusted so that the displacement induced by ARF is equal to that without shielding, almost the same coagulated region can be obtained as in the unshielded case.

  15. Utilization of Curvelet Transform in Reconstructing Cellular Images for Undersampled Optical-resolution Photoacoustic Microscopy

    I Gede Eka Sulistyawan, Daisuke Nishimae, Takuro Ishii, Yoshifumi Saijo

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control　1-1　2023

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tuffc.2023.3272917 　

    ISSN： 0885-3010

    eISSN： 1525-8955

  16. Robust flow vector estimation for echocardiography with extended Nyquist velocity using dual-PRF approach: A flow phantom study Peer-reviewed

    Yuki Okada, Naoya Kanno, Anam Bhatti, Takuro Ishii, Yoshifumi Saijo

    Japanese Journal of Applied Physics　in press　2023

    DOI： 10.35848/1347-4065/acbda6 　

  17. Application of Scanning Acoustic Microscopy for Detection of Dental Caries Lesion

    Yukihiro Naganuma, Kouki Hatori, Masahiro Iikubo, Masatoshi Takahashi, Yoshihiro Hagiwara, Kazuto Kobayashi, Atsushi Takahashi, Kumi Hoshi, Yoshifumi Saijo, Keiichi Sasaki

    Open Journal of Stomatology　13　(01)　12-24　2023

    Publisher: Scientific Research Publishing, Inc.

    DOI： 10.4236/ojst.2023.131002 　

    ISSN： 2160-8709

    eISSN： 2160-8717

  18. Region-based SVD Processing of High-frequency Ultrafast Ultrasound to Visualize Cutaneous Vascular Networks

    Anam Bhatti, Takuro Ishii, Naoya Kanno, Hayato Ikeda, Kennichi Funamoto, Yoshifumi Saijo

    Ultrasonics　129　106907-106907　2022/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.ultras.2022.106907 　

    ISSN： 0041-624X

  19. 体外衝撃波による膝関節拘縮の予防効果 ラット拘縮モデルを用いた検討

    岩津 潤, 萩原 嘉廣, 矢部 裕, 金澤 憲治, 板谷 信行, 曽木 靖仁, 西條 芳文, 相澤 俊峰

    日本整形外科学会雑誌　96　(8)　S1668-S1668　2022/09

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  20. The effects of hydroxyethyl starch 130/0.4 on perioperative renal function in patients undergoing cardiac surgery: A randomised controlled trial Peer-reviewed

    Kei Nagaya, Akiko Yoshida, Yosuke Ito, Suguru Watanabe, Tadanori Minagawa, Yoshifumi Saijo

    Annals of Medicine and Surgery　81　104475-104475　2022/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.amsu.2022.104475 　

    ISSN： 2049-0801

  21. Extracorporeal shockwave therapy in an immobilized knee model in rats prevents progression of joint contracture International-journal Peer-reviewed

    Jun Iwatsu, Yutaka Yabe, Kenji Kanazawa, Nobuyuki Itaya, Yasuhito Sogi, Yoshihumi Saijo, Toshimi Aizawa, Yoshihiro Hagiwara

    Journal of Orthopaedic Research　41　(5)　951-961　2022/08/28

    Publisher: Wiley

    DOI： 10.1002/jor.25433 　

    ISSN： 0736-0266

    eISSN： 1554-527X

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    Joint immobilization, which ensures rest and accelerates tissue recovery in musculoskeletal disorders, often causes joint contracture, for which there is still no effective prevention. To address this, we investigated the effects of extracorporeal shockwave therapy (ESWT) in preventing joint contracture, in a unilaterally immobilized knee rat model. Under general anesthesia, ESWT (0.25 mJ/mm2 , 3000 shot, 4 Hz, 3 days/week) was administered from 1 day after immobilization up to 2, 4, and 6 weeks. The immobilized control group received general anesthesia without ESWT. We evaluated joint angle, tissue elasticity, and gene and protein expression related to fibrosis, inflammation, and angiogenesis in the joint capsule. Relative to the control, the ESWT group had greater joint angle at 4 and 6 weeks, and lower posterior-capsule elasticity at 6 weeks. In the ESWT group, at 6 weeks, gene expression of collagen type I (col1α1), connective tissue growth factor (CTGF), and α-smooth muscle actin (α-SMA) was significantly downregulated, whereas interleukin-6 (IL-6) and hypoxia-inducible factor-1α (HIF-1α) gene expression was upregulated, relative to that in the control. Compared with that in the control, at 4 and 6 weeks, the ratio of CTGF+ cells was significantly lower in the ESWT group; at 4 weeks, the ESWT group had significantly fewer CD68+ cells in the adhesion area, and at 6 weeks, significantly more blood vessels. Statement of Clinical Significance: In a rat model, ESWT counteracted fibrosis, suppressed macrophage infiltration, and promoted neovascularization, reducing elasticity, and increasing joint range-ofmotion. ESWT offers a potential new strategy to prevent progression in joint contracture.

  22. Comparative investigation of coherence factor weighting methods for an annular array photoacoustic microscope Peer-reviewed

    Riku Suzuki, Ryo Shintate, Takuro Ishii, Yoshifumi Saijo

    JAPANESE JOURNAL OF APPLIED PHYSICS　61　(SG)　2022/07

    DOI： 10.35848/1347-4065/ac4684 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  23. 3D ultrasound imaging by synthetic transmit aperture beamforming using a spherically curved array transducer Peer-reviewed

    Eiki Hayashi, Naoya Kanno, Ryo Shintate, Takuro Ishii, Ryo Nagaoka, Yoshifumi Saijo

    Japanese Journal of Applied Physics　61　(SG)　2022/07/01

    DOI： 10.35848/1347-4065/ac51c1 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  24. High-speed optical resolution photoacoustic microscopy with MEMS scanner using a novel and simple distortion correction method. International-journal Peer-reviewed

    Ryo Shintate, Takuro Ishii, Joongho Ahn, Jin Young Kim, Chulhong Kim, Yoshifumi Saijo

    Scientific reports　12　(1)　9221-9221　2022/06/02

    DOI： 10.1038/s41598-022-12865-3 　

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    Optical resolution photoacoustic microscopy (OR-PAM) is a remarkable biomedical imaging technique that can selectively visualize microtissues with optical-dependent high resolution. However, traditional OR-PAM using mechanical stages provides slow imaging speed, making it difficult to biologically interpret in vivo tissue. In this study, we developed a high-speed OR-PAM using a recently commercialized MEMS mirror. This system (MEMS-OR-PAM) consists of a 1-axis MEMS mirror and a mechanical stage. Furthermore, this study proposes a novel calibration method that quickly removes the spatial distortion caused by fast MEMS scanning. The proposed calibration method can easily correct distortions caused by both the scan geometry of the MEMS mirror and its nonlinear motion by running an image sequence only once using a ruler target. The combination of MEMS-OR-PAM and distortion correction method was verified using three experiments: (1) leaf skeleton phantom imaging to test the distortion correction efficacy; (2) spatial resolution and depth of field (DOF) measurement for system performance; (3) in-vivo finger capillary imaging to verify their biomedical use. The results showed that the combination could achieve a high-speed (32 s in 2 × 4 mm) and high lateral resolution (~ 6 µm) imaging capability and precisely visualize the circulating structure of the finger capillaries.

  25. Usefulness of Right Ventricular Free Wall Strain Obtained with Two-Dimensional Speckle-Tracking Echocardiography in Patients with Repaired Tetralogy of Fallot and Pulmonary Regurgitation. Peer-reviewed

    Junko Fujiwara, Shunsuke Tatebe, Kotaro Nochioka, Hideki Ota, Yasuharu Funamizu, Takashi Miki, Yoshikatsu Saiki, Satoshi Yasuda, Yoshifumi Saijo

    The Tohoku journal of experimental medicine　257　(1)　7-15　2022/05/13

    DOI： 10.1620/tjem.2022.J011 　

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    Right ventricular (RV) dysfunction caused by chronic pulmonary regurgitation (PR) is a major determinant of clinical outcome in adults with repaired tetralogy of Fallot (rTOF). However, the accurate assessment of RV function by conventional echocardiography remains challenging. This study tested the feasibility and usefulness of RV free-wall (RVFW) strain obtained by two-dimensional (2D) speckle-tracking echocardiography (STE) in evaluation of RV function in adults with rTOF by comparing cardiac magnetic resonance (CMR) imaging. We enrolled 22 consecutive patients (male/female, 8/14; mean age, 25.0 years) with rTOF who underwent transthoracic echocardiography at Tohoku University Hospital from July 2016 to June 2019. We measured RVFW strain by STE and compared them with 22 hemodynamically normal subjects (NOR) (male/female, 9/13; mean age, 32.0 years). The correlation between RV strain and CMR-derived RV ejection fraction (RVEF) or PR fraction (PRF) were also evaluated. All rTOF patients had more than moderate PR but were near asymptomatic. RVFW longitudinal strain (RVFW-LS) was significantly decreased in the rTOF group compared with that in the NOR group (-19.6 vs. -24.7, P < 0.01). In the rTOF group, RVFW-LS correlated with PRF (r = 0.44, P < 0.05), whereas RVFW circumferential strain at the mid-ventricular level correlated with RVEF (r = 0.57, P < 0.01). Intra-observer variability of RVFW strain was acceptable. These results indicate that RV systolic function and PR severity in rTOF could be assessed by RVFW strain measured by 2D STE. This method is feasible and can be used as a complement to CMR imaging.

  26. 光音響・高周波超音波 東北大学における光音響/高周波超音波イメージング

    西條 芳文, 新楯 諒, 鈴木 陸, 石井 琢郎, 荒川 元孝, 梅村 晋一郎, 吉澤 晋, 長岡 亮, 小林 和人, 根本 隆治

    超音波医学　49　(Suppl.)　S522-S522　2022/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  27. 光音響顕微鏡の画質向上に寄与するコヒーレンスファクタの検討

    鈴木 陸, 新楯 諒, 石井 琢郎, 西條 芳文

    超音波医学　49　(Suppl.)　S800-S800　2022/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  28. Color Doppler shear wave elastography using commercial ultrasound machine with compensated transducer scanning delay. Peer-reviewed

    Norma Hermawan, Takuro Ishii, Yoshifumi Saijo

    Journal of medical ultrasonics (2001)　49　(2)　163-173　2022/04

    DOI： 10.1007/s10396-022-01194-7 　

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    PURPOSE: Tissue elasticity can be measured and mapped using color Doppler elastography. In a previous study, a binary pattern of shear waves was observed using a color flow imaging (CFI) system with matched pulse Doppler packet size as well as shear wave frequency and displacement condition. In the present study, we demonstrate the possibility of mapping shear wave velocity and resolving phantom elasticity using any commercial ultrasound machine without fulfilling that condition. METHODS: We derive a relation between Doppler autocorrelator integration time and the estimated flow velocity. The underlying principles behind the shear wave shadows captured by a typical modern ultrasound machine are investigated. The ultrasound machine measurement preset is calibrated to remove the effect of transducer array scanning delay in modifying the appearing wavenumber and thus correct the measurement error. RESULTS: The method was used to successfully measure the elasticity of a biological tissue-mimicking phantom and distinguish a stiff phantom from a soft phantom. CONCLUSION: Using this method, the elasticity of a biological tissue-mimicking phantom can be recovered with less strict constraint. As a result, it provides more flexibility to be implemented in common ultrasound machines. This method may be practically used to help identify tissue stiffness-related disease.

  29. 機械走査により得られた高周波数超音波データに対する合成開口焦点技術の適応

    井上 大和, 菅野 尚哉, 新楯 諒, 石井 琢郎, 小林 和人, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　121　(380)　1-5　2022/02

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  30. 機械走査により得られた高周波数超音波データに対する合成開口焦点技術の適応

    井上 大和, 菅野 尚哉, 新楯 諒, 石井 琢郎, 小林 和人, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　121　(380)　1-5　2022/02

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  31. Binary Pattern Color Doppler Shear Wave Elastography. International-journal Peer-reviewed

    Norma Hermawan, Aoi Sato, Mizuki Fujiwara, Takuro Ishii, Yoshihiro Hagiwara, Yoshiki Yamakoshi, Yoshifumi Saijo

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2021　3293-3296　2021/11

    DOI： 10.1109/EMBC46164.2021.9630967 　

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    Some studies suggested a correlation between tissue elasticity and diseases, such as Adhesive Capsulitis (AC) of the shoulder. One category of method to measure elasticity is by utilizing Doppler imaging. This paper discusses color Doppler shear wave elastography methods and demonstrated an experiment with biological tissue mimicking phantom. A simulation with binary pattern color Doppler shear wave elastography shows that wavelength of a shear wave with suggested magnitude is equal to four multiple of pitch strip in a color flow image. However, the larger amplitude changes the duty ratio and frequency of the pattern. An experiment with biological tissue mimicking Polyvinyl Alcohol (PVA) phantoms has shown that the binary pattern color Doppler method has successfully recovered shear wave velocity map and calculate the elasticity.Clinical Relevance-The result of experiments presents a possibility of using the method for quantitatively access the stage of tissue stiffness related disease.

  32. 2Pa5-7 3D Ultrasound Imaging by Synthetic Transmit Aperture Beamforming Obtained with a Spherically Curved Array Transducer

    Hayashi Eiki, Kanno Naoya, Shintate Ryo, Ishii Takuro, Nagaoka Ryo, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　42　n/a　2021/10/25

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.42.0_2pa5-7 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  33. 3J4-2 Effect of Coherence Factor Weighting for Improving the Image Quality of an Annular Array Photoacoustic Microscope

    Suzuki Riku, Shintate Ryo, Ishii Takuro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　42　n/a　2021/10/25

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.42.0_3j4-2 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  34. 1J3-2 High-speed Photoacoustic Microscopy Using MEMS Mirror with a Correction Method for Distortion Caused by the Mirror Scanning

    Shintate Ryo, Kim Chulhong, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　42　n/a　2021/10/25

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.42.0_1j3-2 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  35. A Micro-flow Phantom for Superficial Micro-vasculature Imaging Peer-reviewed

    A Bhatti, T Ishii, Y Saijo

    Journal of Physics: Conference Series　2071　(1)　012054-012054　2021/10/01

    Publisher: IOP Publishing

    DOI： 10.1088/1742-6596/2071/1/012054 　

    ISSN： 1742-6588

    eISSN： 1742-6596

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    <title>Abstract</title> Visualization of cutaneous micro-vasculatures is a powerful approach assisting in the diagnosis of skin vascular disorders. These minute structures can be visualized by high-frequency ultrasound (HFUS) using ultrafast Doppler imaging. Ultrasound flow phantoms have been used as assessment tools to evaluate the performance of the ultrasound imaging system, however, to optimize the imaging system for visualization of micro-structures, flow phantom with micro-channels is required which are usually difficult to fabricate. Here, we design a simple approach for micro-flow phantom which is easy to fabricate and cast for detection of micro-circulation in superficial micro-structures. The proposed approach features (i) the micro-channels of 200-micron at the depth of 4 mm (ii) casted in the cryogel mixture of Poly-vinyl alcohol (PVA) and (iii) infused at flow speed of 30 mm/s using infusion pump. Visualization of micro-flow channel in power Doppler image obtained by HFUS ultrafast Doppler imaging reveals that the proposed micro-flow phantom could serve as a viable assessment tool for optimizing the system for in-vivo cutaneous micro-vasculature imaging.

  36. Large Amplitude Harmonic Vibration under Pulse Doppler Measurement Peer-reviewed

    N Hermawan, T Ishii, Y Yamakoshi, Y Saijo

    Journal of Physics: Conference Series　2071　(1)　012034-012034　2021/10/01

    Publisher: IOP Publishing

    DOI： 10.1088/1742-6596/2071/1/012034 　

    ISSN： 1742-6588

    eISSN： 1742-6596

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    <title>Abstract</title> A flow velocity or tissue motion can be measured by pulse Doppler method. However, when the method is applied to a sinusoid motion or harmonic vibration, the estimation result is deviated. In this paper, the generalized theory of pulse Doppler measurement to the sinusoid motion is explained and the relation between the estimation deviation and the real value is given. Furthermore, a special case of binary velocity estimation is expanded and simulated with different parameters. This simulation result suggested that different selection of parameters may fundamentally affect the output of pulse Doppler estimation.

  37. Computer-aided Detection of Lung Tumors in Chest X-ray Images Using a Bone Suppression Algorithm and A Deep Learning Framework Peer-reviewed

    K Sato, N Kanno, T Ishii, Y Saijo

    Journal of Physics: Conference Series　2071　(1)　012002-012002　2021/10/01

    Publisher: IOP Publishing

    DOI： 10.1088/1742-6596/2071/1/012002 　

    ISSN： 1742-6588

    eISSN： 1742-6596

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    <title>Abstract</title> Detecting lung tumors in early stage by reading chest X-ray images is important for radical treatments of the disease. In order to decrease the risk of missed lung tumors, diagnosis support systems that can provide the accurate detection of lung tumors are in high demand, and the use of artificial intelligence with deep learning is one of the promising solutions. In our research, we aim to improve the accuracy of a deep learning-based system for detecting lung tumors by developing a bone suppression algorithm as a preprocessing for the machine-learning model. Our bone suppression algorithm was devised for conventional single-shot chest X-ray images, which do not rely on a specific type of imaging systems. 604 chest X-ray images were processed using the proposed algorithm and evaluated by combining it with a U-net deep learning model. The results showed that the bone suppression algorithm successfully improved the performance of the deep learning model to identify the location of lung tumors (Intersection over Union) from 0.085 (without the bone suppression algorithm) to 0.142, as well as the ability to classify the lung cancer (Area under Curve) that increased from 0.700 to 0.736. The bone suppression algorithm would be useful to improve the accuracy and the reliability of the deep learning-based diagnosis support systems for detecting lung cancer in mass medical examinations.

  38. アニュラアレイセンサへのDAS法応用による光音響顕微鏡像における被写界深度の改善

    鈴木 陸, 新楯 諒, 石井 琢郎, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　121　(182)　23-27　2021/09

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  39. 光を超音波で観る・超音波を光で観る 光学・光音響ハイブリッド顕微鏡による細胞動態イメージング

    新楯 諒, 長岡 亮, 石井 琢郎, 西條 芳文

    超音波医学　48　(Suppl.)　S186-S186　2021/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  40. 左室心筋伸縮伝搬様式の高時間分解能計測

    黒川 貴史, 中島 博行, 高橋 伸一郎, 田中 元直, 金井 浩, 西條 芳文

    超音波医学　48　(2)　73-80　2021/03

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  41. A histoanatomical study of the fiber bundle forming the 'Comma Sign,' a critical marker of the torn edge of the subscapularis tendon. International-journal Peer-reviewed

    Ryuzo Arai, Yoshihiro Hagiwara, Yoshifumi Saijo, Shuichi Matsuda

    Archives of orthopaedic and trauma surgery　2021/01/17

    DOI： 10.1007/s00402-021-03775-6 　

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    INTRODUCTION: The "Comma sign" is a well-known indicator of the subscapularis torn edge of the shoulder. We undertook a histoanatomical study of the fiber bundle forming Comma sign (FBCS) to determine why FBCS is maintained even in cuff tear cases. MATERIALS AND METHODS: Part 1: five tissue blocks including the supraspinatus tendon (SSP), rotator interval (RI), and subscapularis tendon (SSC) out of 5 cuff-intact cadavers were histologically observed in serial sections. Part 2: another tissue blocks of 6 cuff-intact cadavers were serially sectioned along the estimated FBCS direction based on the Part 1 findings. Additionally, 5 tissue blocks of cuff-torn cadavers including the three components, SSP, FBCS, and SSC, were serially sectioned along the apparent FBCS. In one slice clearly demonstrating FBCS fibers out of each section series, the components were measured of the sound speed and visualized through a scanning acoustic microscope (SAM). RESULTS: At the lateral portion, RI tissue with the joint capsule became thick and tightly surrounded SSP. Similarly, thicker RI tissue adhered to SSC from the superior and bursal side. More laterally, the borders of SSP/FBCS and FBCS/SSC were unclear with intermingled fibers. At the lateral most portion, RI tissue formed a fiber bundle, FBCS, extending from SSP to the bursal side of SSC. The sound speeds of SSP and SSC were significantly faster than FBCS in both cuff-intact and cuff-torn slices. In SAM images of cuff-torn specimens the FBCS borders were all unclear. CONCLUSIONS: As FBCS extends from the capsule beneath SSP and to the bursal surface of SSC, the FBCS connection to SSP and SSC is hardly lost, even though SSP or SSC detaches from the greater or lesser tubercle, respectively. Additionally, as degeneration make the elasticity difference gradual, the stress concentration at the borders may be diminished, leading to less breakage of FBCS.

  42. High temporal resolution measurement of propagation pattern of myocardial stretching in left ventricle

    Takafumi KUROKAWA, Hiroyuki NAKAJIMA, Shinichiro TAKAHASHI, Motonao TANAKA, Hiroshi KANAI, Yoshifumi SAIJO

    Choonpa Igaku　48　(2)　73-80　2021

    Publisher: Japan Society of Ultrasonics in Medicine

    DOI： 10.3179/jjmu.jjmu.a.177 　

    ISSN： 1346-1176

    eISSN： 1881-9311

  43. 2E2-2 Optical/Photoacoustic Hybrid Microscopy with Deconvolution Processing for Visualizing Morphology and Composition of Cells

    Shintate Ryo, Nagaoka Ryo, Ishii Takuro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　41　n/a　2020/11/25

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.41.0_2e2-2 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  44. ラット膝関節不動化モデルにおける低出力パルス超音波照射の関節拘縮抑制効果

    板谷 信行, 萩原 嘉廣, 矢部 裕, 金澤 憲治, 小出 将志, 関口 拓也, 曽木 靖仁, 西條 芳文, 井樋 栄二

    超音波医学　47　(Suppl.)　S163-S163　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  45. 細胞の鮮明なイメージングを可能にする高分解能光音響顕微鏡の開発

    新楯 諒, 長岡 亮, 小林 和人, 西條 芳文

    超音波医学　47　(Suppl.)　S189-S189　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  46. 半球型アレイトランスデューサと4方向傾斜レーザ照射による3次元光音響イメージング

    森野 太介, 新楯 諒, 林 瑛己, 長岡 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文

    超音波医学　47　(Suppl.)　S524-S524　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  47. コンケーブアレイプローブを用いた光音響イメージング

    高橋 爽, 西條 芳文, 新楯 諒

    超音波医学　47　(Suppl.)　S525-S525　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  48. 光音響顕微鏡を用いた皮下微小血管の検討

    平塚 竜基, 高橋 爽, 菅野 尚哉, 新楯 諒, 梅村 晋一郎, 西條 芳文

    超音波医学　47　(Suppl.)　S525-S525　2020/11

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  49. The hybrid optical and photoacoustic microscopy: A novel system to image morphological and photoacoustic characteristics of cells

    Ryo Shintate, Ryo Nagaoka, Takuro Ishii, Yoshifumi Saijo

    IEEE International Ultrasonics Symposium, IUS　2020-September　2020/09/07

    DOI： 10.1109/IUS46767.2020.9251548 　

    ISSN： 1948-5719

    eISSN： 1948-5727

  50. アニュラアレイトランスデューサを用いた音響分解能光音響顕微鏡によるイメージング

    平塚 竜基, 高橋 爽, 佐藤 滉太, 新楯 諒, 梅村 晋一郎, 石井 琢郎, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　120　(174)　73-77　2020/09

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  51. コンケーブアレイプローブを用いた光音響イメージングにおける単方向・多方向送受信の比較検討

    高橋 爽, 新楯 諒, 川口 航汰, 菅野 尚哉, 佐藤 滉太, 石井 琢郎, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　120　(174)　78-82　2020/09

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  52. 乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

    藤原 淳子, 後岡 広太郎, 杉村 宏一郎, 照井 洋輔, 佐藤 遥, 多田 寛, 大田 英揮, 船水 康陽, 三木 俊, 西條 芳文, 高瀬 圭, 石田 孝宜, 下川 宏明

    日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07

    Publisher: (一社)日本循環器学会

  53. 乳癌患者における化学療法による心毒性が原因の局所左室変形に関する経時的変化(Longitudinal Change of Regional Left Ventricular Deformation by Chemotherapy-induced Cardiotoxicity in Patients with Breast Cancer)

    藤原 淳子, 後岡 広太郎, 杉村 宏一郎, 照井 洋輔, 佐藤 遥, 多田 寛, 大田 英揮, 船水 康陽, 三木 俊, 西條 芳文, 高瀬 圭, 石田 孝宜, 下川 宏明

    日本循環器学会学術集会抄録集　84回　OJ12-6　2020/07

    Publisher: (一社)日本循環器学会

  54. Development of optical resolution photoacoustic microscopy with sub-micron lateral resolution for visualization of cells and their structures Peer-reviewed

    Ryo Shintate, Taisuke Morino, Kota Kawaguchi, Ryo Nagaoka, Kazuto Kobayashi, Makoto Kanzaki, Yoshifumi Saijo

    Japanese Journal of Applied Physics　59　2020/07/01

    DOI： 10.35848/1347-4065/ab840e 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  55. Visualization of Shoulder Ligaments Motion by Ultrasound Speckle Tracking Method. International-journal Peer-reviewed

    Norma Hermawan, Mizuki Fujiwara, Yoshihiro Hagiwara, Yoshifumi Saijo

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2020　2084-2087　2020/07

    DOI： 10.1109/EMBC44109.2020.9176374 　

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    There is no unified consensus on the pathophysiology of adhesive capsulitis which is also called as frozen shoulder. Some studies have suggested that coracohumeral ligament (CHL) played an important role in adhesive capsulitis. These studies showed relation between disease prevalence and CHL thickness by means of ultrasound or MRI. Other possible etiology of the disease is the adhesion of shoulder ligament with each other. In the present study, shoulder ligaments motion is visualized with velocity vector by speckle tracking and temporal outlier removal algorithm to process ultrasound movie during forced movement of shoulder joint. The measurement with a typical subject has demonstrated an improvement of velocity vector deviation of up to 43% by the proposed outlier removal technique.

  56. 2P5-14 Visualization of cell structure by optical resolution photoacoustic microscopy with sub-micron lateral resolution

    Shintate Ryo, Nagaoka Ryo, Kobayashi Kazuto, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　40　n/a　2019/11/25

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.40.0_2p5-14 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  57. Validation of Echodynamography in Comparison with Particle-image Velocimetry

    Sri Oktamuliani, Naoya Kanno, Moe Maeda, Kaoru Hasegawa, Yoshifumi Saijo

    Ultrasonic Imaging　41　(6)　336-352　2019/11/01

    Publisher: SAGE Publications Inc.

    DOI： 10.1177/0161734619879859 　

    ISSN： 0161-7346

  58. Role of intra-ventricular vortex in left ventricular ejection elucidated by echo-dynamography Peer-reviewed

    Motonao Tanaka, Tsuguya Sakamoto, Yoshifumi Saijo, Yoshiaki Katahira, Shigeo Sugawara, Hiroyuki Nakajima, Takafumi Kurokawa, Hiroshi Kanai

    Journal of Medical Ultrasonics　46　(4)　413-423　2019/10/01

    DOI： 10.1007/s10396-019-00943-5 　

    ISSN： 1346-4523

    eISSN： 1613-2254

  59. Left Ventricular Vortices in Myocardial Infarction Observed with Echodynamography

    Sri Oktamuliani, Kaoru Hasegawa, Yoshifumi Saijo

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　5816-5819　2019/07/01

    Publisher: Institute of Electrical and Electronics Engineers Inc.

    DOI： 10.1109/EMBC.2019.8856394 　

    ISSN： 1557-170X

  60. Biomechanics of C2C12 Cells Observed with Cellular Resolution Scanning Acoustic Microscope Combined with Optical Microscope. International-journal Peer-reviewed

    Ryo Hirano, Makoto Kanzaki, Mototaka Arakawa, Norma Hermawan, Kazuto Kobayashi, Yoshifumi Saijo

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2019　4828-4831　2019/07

    DOI： 10.1109/EMBC.2019.8857008 　

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    Biomechanics of the cell indicates the inner structure and viability of the cell. Mechanical properties are represented by acoustic properties such as speed of sound (SOS) or acoustic impedance. In the present study, cellular resolution scanning acoustic microscope combined with optical microscope (OptSAM) is developed to observe the change of mechanical properties in cell differentiation. Main part of the OptSAM was consisted of 350 MHz ultrasound transducer mechanically scanned by a piezo-actuator. Thickness, SOS, acoustic impedance, density and elastic bulk modulus of the cell were deduced by the ultrasound responses in both time domain and frequency domain. C2C12 cell changing its form from myoblast to myotube was observed by OptSAM. The value of bulk modulus slightly increased in response to differentiation process. OptSAM non-invasively provides important information on biomechanics of cells without contact or staining.

  61. Multidirectional reception of photoacoustic signals for higher resolution imaging Peer-reviewed

    Kanta Sato, Ryo Shintate, Mitsuhiro Fujiwara, Yoshifumi Saijo

    Japanese Journal of Applied Physics　58　(SG)　2019

    DOI： 10.7567/1347-4065/ab19b7 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  62. Blood flow imaging using singular value decomposition filter during high-intensity focused ultrasound exposure

    Hayato Ikeda, Shin Yoshizawa, Moe Maeda, Shin Ichiro Umemura, Yoshifumi Saijo

    Japanese Journal of Applied Physics　58　2019/01/01

    DOI： 10.7567/1347-4065/ab1a2e 　

    ISSN： 0021-4922

  63. Correction of phase rotation in pulse spectrum method for scanning acoustic microscopy and its application to measurements of cells Peer-reviewed

    Nagaoka R, Kobayashi K, Arakawa M, Hasegawa H, Saijo Y

    Ultrasonics　99　2019

    DOI： 10.1016/j.ultras.2019.105949 　

  64. Medical imaging: Acoustic microscopy (AM)

    穂積直裕, 西條芳文

    応用物理　87　(12)　932‐936-936　2018/12/10

    Publisher: 応用物理学会

    DOI： 10.11470/oubutsu.87.12_932 　

    ISSN： 0369-8009

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    <p>Biological acoustic microscopy makes it possible to acquire quantitative acoustic parameters such as sound speed and acoustic impedance that can be correlated to hardness of the tissue. As it does not need the staining process that is normally required in optical observation, a non-invasive observation of living tissues and cells can be realized. Its outline and some examples of observations will be described.</p>

  65. The Structure of Human Sebaceous Glands and Its Relation to Skin Viscoelasticity

    Kazutoshi Kumagai, Saaya Yokoshiki, Kazuto Kobayashi, Yoshifumi Saijo

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2018-　3460-3463　2018/10/26

    Publisher: Institute of Electrical and Electronics Engineers Inc.

    DOI： 10.1109/EMBC.2018.8512966 　

    ISSN： 1557-170X

  66. Optical Resolution Photoacoustic Microscopy with Fast Laser Scanning and Fixed Photoacoustic Detector∗ Peer-reviewed

    Kodai Ishikawa, Ryo Shintate, Ryo Nagaoka, Yoshifumi Saijo

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2018-July　4800-4803　2018/10/26

    DOI： 10.1109/EMBC.2018.8513104 　

    ISSN： 1557-170X

  67. Photoacoustic image denoising using dictionary learning

    Syahril Siregar, Yoshifumi Saijo

    ACM International Conference Proceeding Series　34-37　2018/08/22

    Publisher: Association for Computing Machinery

    DOI： 10.1145/3278229.3278230 　

  68. Correction of aliasing in color Doppler echocardiography based on image processing technique in echodynamography

    Sri Oktamuliani, Kaoru Hasegawa, Yoshifumi Saijo

    ACM International Conference Proceeding Series　1-5　2018/08/22

    Publisher: Association for Computing Machinery

    DOI： 10.1145/3278229.3278233 　

  69. A theoretical model of laser heating carbon nanotubes. Peer-reviewed

    Siregar S, Oktamuliani S, Saijo Y

    Nanomaterials　8　580　2018/08

    DOI： 10.3390/nano8080580 　

  70. Blood Flow Patterns in the Left Ventricle by Echodynamography Method

    Sri Oktamuliani, Kaoru Hasegawa, Yoshifumi Saijo

    2018 International Conference on Orange Technologies, ICOT 2018　2018/07/02

    Publisher: Institute of Electrical and Electronics Engineers Inc.

    DOI： 10.1109/ICOT.2018.8705826 　

  71. Left Ventricular Blood Flow Dynamics In Aortic Stenosis Before And After Aortic Valve Replacement. International-journal Peer-reviewed

    Tadanori Minagawa, Yoshifumi Saijo, Sri Oktamuliani, Takafumi Kurokawa, Hiroyuki Nakajima, Kaoru Hasegawa, Takayuki Matsuoka, Takuya Shimizu, Makoto Miura, Takahiro Ohara, Shunsuke Kawamoto

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2018　3177-3180　2018/07

    Publisher: IEEE

    DOI： 10.1109/EMBC.2018.8512954 　

    ISSN： 1557-170X

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    Surgical intervention for aortic valve stenosis (AS) has been established; however its diagnosis based on echocardiographic assessment is still limited by aortic valvular velocity, aortic valvular pressure gradients, and color Doppler imaging. Echo-dynamography (EDG) is a method to determine intracardiac flow dynamics, such as two-dimensional blood flow velocity, vortex, and dynamic pressure. These flow dynamics may be influenced by left ventricular (LV) wall motion and the resistance in LV outflow caused by AS. The objective of the present study was to assess the changes and differences in LV vortices and vorticity before and after AS surgery. Five patients who underwent aortic valve replacement surgery for AS and five control patients were included. Besides routine echocardiographic measurement, EDG was applied to determine the two-dimensional blood flow vector and vorticity. The LV vortex flow in the isovolumetric contraction phase had multiple formations in preoperative cases. The clockwise vortex was found in all cases postoperatively; the vortex formation showed no significant difference between postoperative and normal control groups. EDG may serve important information on LV flow dynamics, non-invasively.

  72. Development of new human thermal model based on blood flow rate measurements under different temperature conditions Peer-reviewed

    T Goto, D Terayama, H Sakamoto, T Hayase, Y Saijo, R Sugawara, Z Niu

    15th Conference of the International Society of Indoor Air Quality and Climate (Indoor Air 2018)　2018/07

  73. EFFECTS OF LOW-INTENSITY PULSED ULTRASOUND FOR PREVENTING JOINT STIFFNESS IN IMMOBILIZED KNEE MODEL IN RATS Peer-reviewed

    Itaya, Nobuyuki, Yabe, Yutake, Hagiwara, Yoshihiro, Kanazawa, Kenji, Koide, Masashi, Sekiguchi, Takuya, Yoshida, Shinichirou, Sogi, Yasuhito, Yano, Toshihisa, Tsuchiya, Masahiro, Saijo, Yoshifumi, Itoi, Eiji

    ULTRASOUND IN MEDICINE AND BIOLOGY　44　(6)　1244-1256　2018/06

    DOI： 10.1016/j.ultrasmedbio.2018.02.002 　

    ISSN： 0301-5629

    eISSN： 1879-291X

  74. Visualization of murine lymph vessels using photoacoustic imaging with contrast agents Peer-reviewed

    Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

    Photoacoustics　9　39-48　2018/03/01

    Publisher: Elsevier GmbH

    DOI： 10.1016/j.pacs.2018.01.001 　

    ISSN： 2213-5979

  75. A method for the design of ultrasonic devices for scanning acoustic microscopy using impulsive signals Peer-reviewed

    Mototaka Arakawa, Hiroshi Kanai, Kazuo Ishikawa, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo

    Ultrasonics　84　172-179　2018/03/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.ultras.2017.10.023 　

    ISSN： 0041-624X

  76. Singular value decomposition of received ultrasound signal to separate tissue, blood flow, and cavitation signals. Peer-reviewed

    Ikeda H, Nagaoka R, Lafond M, Yoshizawa S, Iwasaki R, Maeda M, Umemura SI, Saijo Y

    Jpn J Appl Phys　57　07LF04　2018

    DOI： 10.7567/JJAP.57.07LF04 　

  77. Deduction of two-dimensional blood flow vector by dual angle diverging waves from a cardiac sector probe. Peer-reviewed

    Maeda M, Nagaoka R, Ikeda H, Yaegashi S, Saijo Y

    Jpn J Appl Phys　57　07LF02　2018

    DOI： 10.7567/JJAP.57.07LF02 　

  78. Basic study of improvement of axial resolution and suppression of time side lobe by phase-corrected Wiener filtering in photoacoustic tomography. Peer-reviewed

    Nagaoka R, Yoshizawa S, Umemura SI, Saijo Y

    Jpn J Appl Phys　57　07LD11　2018

    DOI： 10.7567/JJAP.57.07LD11 　

  79. Robust analysis method for acoustic properties of biological specimens measured by acoustic microscopy. Peer-reviewed

    Arakawa M, Mori S, Kanai H, Nagaoka R, Horie M, Kobayashi K, Saijo Y

    Jpn J Appl Phys　57　(7)　07LB07　2018

    DOI： 10.7567/JJAP.57. 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  80. Non local means denoising in photoacoustic imaging. Peer-reviewed

    Siregar S, Nagaoka R, Ul Haq I, Saijo Y

    Jpn J Appl Phys　57　07L B06　2018

    DOI： 10.7567/JJAP.57.07LB06 　

  81. Visualization of the microcirculation in micro vasculatures by photoacoustic tomography with high frequency spherical array transducer Peer-reviewed

    Ryo Nagaoka, Takuya Tabata, Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo

    IEEE International Ultrasonics Symposium, IUS　2017/10/31

    Publisher: IEEE Computer Society

    DOI： 10.1109/ULTSYM.2017.8092091 　

    ISSN： 1948-5727 1948-5719

    eISSN： 1948-5727

  82. Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer Peer-reviewed

    Ryo Nagaoka, Takuya Tabata, Ryo Takagi, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo

    IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL　64　(8)　1223-1233　2017/08

    DOI： 10.1109/TUFFC.2017.2718030 　

    ISSN： 0885-3010

    eISSN： 1525-8955

  83. Sparse-representation-based denoising of photoacoustic images Peer-reviewed

    Israr Ul Haq, Ryo Nagaoka, Syahril Siregar, Yoshifumi Saijo

    Biomedical Physics and Engineering Express　3　(4)　045014　2017/07/10

    Publisher: Institute of Physics Publishing

    DOI： 10.1088/2057-1976/aa7a44 　

    ISSN： 2057-1976

  84. Graduate School of Biomedical Engineering at Tohoku University The history of foundation and recent education program on global entrepreneur of medical devices

    Saijo Yoshifumi

    Transactions of Japanese Society for Medical and Biological Engineering　55　(3)　192-192　2017

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.55Annual.192 　

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    <p>Graduate School of Biomedical Engineering was founded in 2008 as Japan's first independent graduate school specialized in biomedical engineering. Tohoku</p>

  85. Evaluation of blood flow dynamics in healthy and myocardial infarction hearts using Echodynamography Peer-reviewed

    Sri Oktamuliana, Yoshifumi Saijo, Kaoru Hasegawa

    Proceedings of Meetings on Acoustics　32　(1)　2017

    Publisher: Acoustical Society of America

    DOI： 10.1121/2.0000716 　

    ISSN： 1939-800X

  86. Differentiation of Vein and Lymphatic Vessel by Photoacoustic Imaging System with Parabolic Array Transducer and Tunable Laser Peer-reviewed

    Takuya Tabata, Ryo Nagaoka, ShinIchiro Umemura, Yoshifumi Saijo, Shin Yoshizawa

    2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　2017

    ISSN： 1948-5719

  87. Assessment of Inter-Expert Variability and of an Automated Segmentation Method of 40 and 60 MHz IVUS Images of Coronary Arteries Peer-reviewed

    Francois Destrempes, Marie-Helene Roy Cardinal, Yoshifumi Saijo, Gerard Finet, Jean-Claude Tardif, Guy Cloutier

    PLOS ONE　12　(1)　e0168332　2017/01

    DOI： 10.1371/journal.pone.0168332 　

    ISSN： 1932-6203

  88. Measurement of blood flow rates under three different temperatures, and development of a new human thermal model

    Daiki Terayama, Hiroto Sakamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomonobu Goto

    The 5th International Conference on Human-Environment System　2016/10/29

  89. Changes of masseter muscle in a rat unilateral occlusal model assessed by photoacoustic imaging system

    Kouki Hatori, Yoshifumi Saijo, Masahiro Iikubo, Yoshihiro Hagiwara, Kuniyuki Izumita, Yukihiro Naganuma, Keiichi Sasaki

    The Journal of the Acoustical Society of America　140　(4)　2980-2980　2016/10

    Publisher: Acoustical Society of America (ASA)

    DOI： 10.1121/1.4969225 　

    ISSN： 0001-4966

  90. 経皮的肺動脈形成術治療が施行された慢性血栓塞栓性肺高血圧患者における心エコーによる右室機能評価法の検討

    藤原 淳子, 船水 康陽, 三木 俊, 建部 俊介, 青木 竜男, 大田 英揮, 杉村 宏一郎, 坂田 泰彦, 西條 芳文, 下川 宏明

    超音波医学　43　(4)　603-603　2016/07

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  91. Differences between cardiac memory T wave changes after idiopathic left ventricular tachycardia and ischemic T wave inversion induced by acute coronary syndrome Peer-reviewed

    Takashi Nakagawa, Tetsuo Yagi, Akihiko Ishida, Yoshiaki Mibiki, Yoshihiro Yamashina, Hirokazu Sato, Eiji Sato, Juri Komatsu, Yoshifumi Saijo

    Journal of Electrocardiology　49　(4)　596-602　2016/07/01

    Publisher: Churchill Livingstone Inc.

    DOI： 10.1016/j.jelectrocard.2016.04.001 　

    ISSN： 1532-8430 0022-0736

  92. Monitoring of high-intensity focused ultrasound treatment by shear wave elastography induced by two-dimensional-array therapeutic transducer Peer-reviewed

    Ryosuke Iwasaki, Ryo Takagi, Ryo Nagaoka, Hayato Jimbo, Shin Yoshizawa, Yoshifumi Saijo, Shin-ichiro Umemura

    JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07KF05　2016/07

    DOI： 10.7567/JJAP.55.07KF05 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  93. たこつぼ型心筋症の部位別頻度と回復期における心形態変化の特徴

    佐々木 絵里奈, 伊藤 記彦, 稲葉 綾香, 長尾 祥史, 小泉 真澄, 遠藤 洋一, 藤原 淳子, 船水 康陽, 三木 俊, 青木 竜男, 西條 芳文

    超音波検査技術　41　(Suppl.)　S136-S136　2016/06

    Publisher: (一社)日本超音波検査学会

    ISSN： 1881-4506

    eISSN： 1881-4514

  94. 経胸壁心エコー検査によるLibman-Sacks心内膜炎評価の検討

    小泉 真澄, 藤原 淳子, 遠藤 洋一, 船水 康陽, 三木 俊, 青木 竜男, 西條 芳文

    超音波検査技術　41　(Suppl.)　S139-S139　2016/06

    Publisher: (一社)日本超音波検査学会

    ISSN： 1881-4506

    eISSN： 1881-4514

  95. 心臓移植後早期に拒絶反応を呈した1症例

    遠藤 洋一, 青木, 竜男, 藤原, 淳子, 船水, 康陽, 三木, 俊, 西條, 西條 芳文, 杉村, 宏一郎, 秋山, 正年, 川本, 俊輔, 齋木, 佳克, 下川 宏明

    超音波検査技術　41　(Suppl.)　S151-S151　2016/06

    Publisher:

    DOI： 10.11272/jssabst.41.0_S151_2 　

    ISSN： 1881-4506

    eISSN： 1881-4514

  96. Eisenmenger Syndromeに肺移植と心内修復術を施行した一例

    伊藤 記彦, 青木 竜男, 船水 康陽, 藤原 淳子, 三木 俊, 西條 芳文, 建部 俊介, 杉村 宏一郎, 岡田 克典, 下川 宏明

    超音波医学　43　(Suppl.)　S585-S585　2016/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  97. Activities of Japan Society of Medical Ultrasonics in Miyagi Prefecture after Great East Japan Earthquake

    SAIJO Yoshifumi

    Choonpa Igaku　43　(1)　55-59　2016

    Publisher: The Japan Society of Ultrasonics in Medicine

    DOI： 10.3179/jjmu.JJMU.R.71 　

    ISSN： 1346-1176

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    The activities of the Japan Society of Medical Ultrasonics in Miyagi Prefecture after the Great East Japan Earthquake are described.

  98. Two-dimensional Blood Flow Vector and Wall Shear Stress of Carotid Artery Obtained with Dual-angle Doppler Method Peer-reviewed

    Osamu Akagawa, Kosuke Fukazu, Ryo Nagaoka, Yoshifumi Saijo

    2016 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　2016

    ISSN： 1948-5719

  99. Non-invasive in-situ quantitative observation of biological cells by acoustic microscopy Peer-reviewed

    Naohiro Hozumi, Kyoichi Takanashi, Mamoru Washiya, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo

    The Journal of the Acoustical Society of America　140　(4)　3245　2016

  100. A novel biodegradable external mesh stent improved long-term patency of vein grafts by inhibiting intimal-medial hyperplasia in an experimental canine model. Peer-reviewed

    Sato A, Kawamoto S, Watanabe M, Suzuki Y, Takahashi G, Masaki N, Kumagai K, Saijo Y, Tabayashi K, Saiki Y

    General thoracic and cardiovascular surgery　64　(1)　1-9　2016/01

    DOI： 10.1007/s11748-015-0591-2 　

    ISSN： 1863-6705

  101. Acoustic Impedance Estimation Using Calibration Curve for Scanning Acoustic Impedance Microscope Peer-reviewed

    Gunawan Agus Indra, Saijo Yoshifumi, Hozumi Naohiro, Yoshida Sachiko, Kobayashi Kazuto, Yamamoto Seiji

    2016 INTERNATIONAL CONFERENCE ON KNOWLEDGE CREATION AND INTELLIGENT COMPUTING (KCIC)　240-245　2016

  102. Perspective Imaging of Flow in Arterial Model Obtained with Continuous Wave Doppler Focusing Technique Peer-reviewed

    Ryo Nagaoka, Katsuhiro Sasaki, Seiichi Zama, Masaaki Nagone, Hiroshi Nagai, Yasuhito Takeuchi, Yoshifumi Saijo

    2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2315-2318　2016

    DOI： 10.1109/EMBC.2016.7591193 　

    ISSN： 1557-170X

  103. 3D Gabor Wavelet based Vessel Filtering of Photoacoustic Images Peer-reviewed

    Israr Ul Haq, Ryo Nagoaka, Takahiro Makino, Takuya Tabata, Yoshifumi Saijo

    2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　3883-3886　2016

    DOI： 10.1109/EMBC.2016.7591576 　

    ISSN： 1557-170X

  104. Numerical analysis of acoustic impedance microscope utilizing acoustic lens transducer to examine cultured cells Peer-reviewed

    Agus Indra Gunawan, Naohiro Hozumi, Kenta Takahashi, Sachiko Yoshida, Yoshifumi Saijo, Kazuto Kobayashi, Seiji Yamamoto

    ULTRASONICS　63　102-110　2015/12

    DOI： 10.1016/j.ultras.2015.06.016 　

    ISSN： 0041-624X

    eISSN： 1874-9968

  105. In memory: Floyd Dunn Peer-reviewed

    Yoshifumi Saijo

    Journal of Medical Ultrasonics　42　(4)　605　2015/10/01

    Publisher: Springer-Verlag Tokyo

    DOI： 10.1007/s10396-015-0656-y 　

    ISSN： 1613-2254 1346-4523

  106. Viscoelastic Imaging Using Acoustic Impedance Microscope and Its Application to Biological Tissue Peer-reviewed

    Naohiro Hozumi, Shota Kajima, Agus Indra Gunawan, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo, Seiji Yamamoto

    2015 IEEE International Ultrasonics Symposium　1G-4　2015/10

    DOI： 10.1109/ULTSYM.2015.0172 　

    ISSN： 1948-5719

  107. Development of an Ultrasound Microscope Combined With Optical Microscope for Multiparametric Characterization of a Single Cell Peer-reviewed

    Mototaka Arakawa, Joe Shikama, Koki Yoshida, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo

    IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL　62　(9)　1615-1622　2015/09

    DOI： 10.1109/TUFFC.2014.006865 　

    ISSN： 0885-3010

    eISSN： 1525-8955

  108. Numerical analysis of ultrasound propagation and reflection intensity for biological acoustic impedance microscope Peer-reviewed

    Agus Indra Gunawan, Naohiro Hozumi, Sachiko Yoshida, Yoshifumi Saijo, Kazuto Kobayashi, Seiji Yamamoto

    ULTRASONICS　61　79-87　2015/08

    DOI： 10.1016/j.ultras.2015.03.010 　

    ISSN： 0041-624X

    eISSN： 1874-9968

  109. Effects of cavitation-enhanced heating in high-intensity focused ultrasound treatment on shear wave imaging Peer-reviewed

    Ryosuke Iwasaki, Ryo Nagaoka, Ryo Takagi, Kota Goto, Shin Yoshizawa, Yoshifumi Saijo, Shin-ichiro Umemura

    JAPANESE JOURNAL OF APPLIED PHYSICS　54　(7)　07HF21　2015/07

    DOI： 10.7567/JJAP.54.07HF11 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  110. Measurements of Blood Flow and Blood Pressure under Different Indoor Temperature and Body Postural Conditions, and Development of a New Human Simulation Model Peer-reviewed

    H. Sakamoto, Y. Chiba, T. Hayase, K. Funamoto, Y. Saijo, T. Goto

    Healthy Buildings Europe 2015　437-1-437-8　2015/05/18

  111. 腱板骨付着部変性における酸化ストレスの寄与

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西條 芳文, 金子 和夫, 野沢 雅彦, 清水 孝彦

    日本整形外科学会雑誌　89　(2)　S434-S434　2015/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  112. Simultaneous evaluation of articular cartilage and subchondral bone from immobilized knee in rats by photoacoustic imaging system Peer-reviewed

    Yoshihiro Hagiwara, Takuya Izumi, Yutaka Yabe, Mika Sato, Kazuaki Sonofuchi, Kenji Kanazawa, Masashi Koide, Yoshifumi Saijo, Eiji Itoi

    JOURNAL OF ORTHOPAEDIC SCIENCE　20　(2)　397-402　2015/03

    DOI： 10.1007/s00776-014-0692-2 　

    ISSN： 0949-2658

    eISSN： 1436-2023

  113. Measurement of skin elasticity using high frequency ultrasound elastography with intrinsic deformation induced by arterial pulsation Peer-reviewed

    Ryo Nagaoka, Yoshifumi Saijo

    Interface Oral Health Science 2014: Innovative Research on Biosis-Abiosis Intelligent Interface　245-255　2015/01/01

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-55192-8_21 　

  114. Adaptive Spatial Filtering with Principal Component Analysis for Biomedical Photoacoustic Imaging Peer-reviewed

    Ryo Nagaoka, Rena Yamazaki, Yoshifumi Saijo

    Proceedings of the 2015 ICU International Congress on Ultrasonics　70　1161-1164　2015

    DOI： 10.1016/j.phpro.2015.08.249 　

    ISSN： 1875-3892

  115. Monitoring of lesions induced by cavitation-enhanced high-intensity focused ultrasound using shear wave elastography Peer-reviewed

    Iwasaki, R, Nagaoka, R, Saijo, Y, Umemura, S.-I, Takagi, R, Jimbo, H, Yoshizawa, S

    IEEE Int. Ultrason. Symp., IUS　7329182　2015

    DOI： 10.1109/ULTSYM.2015.0042 　

  116. Measurement of acoustic properties of cells using high frequency acoustic microscopy

    T. Igo, M. Arakawa, K. Kobayashi, R. Nagaoka, Y. Saijo

    Proc. 13th International Symp. Advanced Biomedical Ultrasound　20-20　2015

  117. Basic study of intrinsic elastography: Relationship between tissue stiffness and propagation velocity of deformation induced by pulsatile flow Peer-reviewed

    Nagaoka, R, Iwasaki, R, Arakawa, M, Kobayashi, K, Yoshizawa, S, Umemura, S.-I, Saijo, Y

    Japanese Journal of Applied Physics　54　(7)　07HF08　2015

    Publisher: Institute of Physics

    DOI： 10.7567/JJAP.54.07HF08 　

    ISSN： 0021-4922

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    We proposed an estimation method for a tissue stiffness from deformations induced by arterial pulsation, and named this proposed method intrinsic elastography (IE). In IE, assuming that the velocity of the deformation propagation in tissues is closely related to the stiffness, the propagation velocity (PV) was estimated by spatial compound ultrasound imaging with a high temporal resolution of 1 ms. However, the relationship between tissue stiffness and PV has not been revealed yet. In this study, the PV of the deformation induced by the pulsatile pump was measured by IE in three different poly(vinyl alcohol) (PVA) phantoms of different stiffnesses. The measured PV was compared with the shear wave velocity (SWV) measured by shear wave imaging (SWI). The measured PV has trends similar to the measured SWV. These results obtained by IE in a healthy male show the possibility that the mechanical properties of living tissues could be evaluated by IE.

  118. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model. Peer-reviewed

    Kanazawa K, Hagiwara Y, Tsuchiya M, Yabe Y, Sonofuchi K, Koide M, Sekiguchi T, Itaya N, Ando A, Saijo Y, Itoi E

    International journal of clinical and experimental pathology　8　(4)　3426-3440　2015

  119. Macrophage with Gold Nanorod Visualized by Optical-Resolution and Acoustic-Resolution Photoacoustic Microscopes Peer-reviewed

    Rena Yamazaki, Koetsu Ogasawara, Mitsuhiro Fujiwara, Kazuto Kobayashi, Yoshifumi Saijo

    2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2387-2390　2015

    DOI： 10.1109/EMBC.2015.7318874 　

    ISSN： 1557-170X

  120. Intrinsic Elastography and Its Dependence on Arterial Flow Volume Peer-reviewed

    Ryo Nagaoka, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

    2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　6309-6312　2015

    DOI： 10.1109/EMBC.2015.7319835 　

    ISSN： 1557-170X

  121. Measurement of regional pulse-wave velocity using spatial compound imaging of the common carotid artery in vivo Peer-reviewed

    Ryo Nagaoka, Genta Masuno, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

    ULTRASONICS　55　92-103　2015/01

    DOI： 10.1016/j.ultras.2014.07.018 　

    ISSN： 0041-624X

    eISSN： 1874-9968

  122. Joint haemorrhage partly accelerated immobilization-induced synovial adhesions and capsular shortening in rats. International-journal Peer-reviewed

    Yoshito Onoda, Yoshihiro Hagiwara, Akira Ando, Takashi Watanabe, Eiichi Chimoto, Hideaki Suda, Yutaka Yabe, Yoshifumi Saijo, Eiji Itoi

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　22　(11)　2874-83　2014/11

    DOI： 10.1007/s00167-013-2659-9 　

    ISSN： 0942-2056

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    PURPOSE: To elucidate the effects of intra-articular haemorrhage on the joint capsule of immobilized knees in rats. METHODS: The unilateral knee joints were immobilized using a plastic plate and screws. Sham operated rats had only screws inserted. A single injection of fresh autologous blood was given postoperatively into the knee joints of the immobilized blood injection (Im-B) and the Sham blood injection (Sm-B) groups. Normal saline was administered for the immobilized-saline injection (Im-S) group. Sagittal sections were prepared from the medial midcondylar region of the knee and assessed with histological, histomorphometric, and immunohistochemical methods. The range of motion (ROM) was measured, and the mechanical property of the capsule was assessed by scanning acoustic microscope. RESULTS: Absorption of the injected blood was delayed and made severe adhesions in the Im-B group. The length of the synovial membrane in the Im-B group was significantly shorter than that of the other groups. The ROM was significantly restricted in the Im-B group compared with the other groups. The elasticity of the posterior capsule in the Im-B group was significantly lower than that in the Sm-B group. Iron deposition was observed in the Im-B and Sm-B groups. Strong immunoreactivities of CD68, TGF-β1, and α-SMA were observed in the adhesion area of the Im-B group. Joint immobilization with blood injection caused severe capsular adhesion and limited range of motion. Immunostaining related to fibrosis increased with joint haemorrhage. CONCLUSION: Intra-articular haemorrhage with joint immobilization might be an accelerated risk factor for joint contracture. It is likely that leaving a haematoma inside an immobilized joint should be avoided.

  123. Acoustic impedance microscopy for biological tissue characterization Peer-reviewed

    Kazuto Kobayashi, Sachiko Yoshida, Yoshifumi Saijo, Naohiro Hozumi

    ULTRASONICS　54　(7)　1922-1928　2014/09

    DOI： 10.1016/j.ultras.2014.04.007 　

    ISSN： 0041-624X

    eISSN： 1874-9968

  124. Studies on the basic technology of “Sono-cytometry” Peer-reviewed

    Yosuke Komatsu, Ryo Nagaoka, Kenichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　351-O-352　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-351 　

    ISSN： 1347-443X 1881-4379

  125. Automated detection of optic disc using vessels tracking Peer-reviewed

    Israr Ul Haq, Usman Akram, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　283-O-284　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-283 　

    ISSN： 1347-443X 1881-4379

  126. Measurement of sound speed of skin by using ultrasonic microscopy Peer-reviewed

    Miki Horie, Ryo Nagaoka, Kazuto Kobayashi, Kenshi Yamazaki, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　323-O-324　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-323 　

    ISSN： 1347-443X 1881-4379

  127. Development of innovative photoacoustic microscopy with application of transparent piezo-electronic element Peer-reviewed

    Yoshifumi Saijo, Yuji Matsuura, Katsuyoshi Washio

    Transactions of Japanese Society for Medical and Biological Engineering　52　56-SY-57　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.SY-56 　

    ISSN： 1347-443X 1881-4379

  128. Measurement of acoustic parameters of single cell by ultrasound microscope Peer-reviewed

    Koki Yoshida, Rami Abuhabsah, Alexander D. Pawlicki, Joe Shikama, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo, William D. O'Brien

    Transactions of Japanese Society for Medical and Biological Engineering　52　341-O-342　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-341 　

    ISSN： 1347-443X 1881-4379

  129. Beam profile measurement and optimization in the high-frequency annular array transducer Peer-reviewed

    Akira Tada, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　355-O-356　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-355 　

    ISSN： 1347-443X 1881-4379

  130. Development of acoustic microscope for biological tissue and its application Peer-reviewed

    Mototaka Arakawa, Joe Shikama, Koki Yoshida, Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　5-SY-6　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.SY-5 　

    ISSN： 1347-443X 1881-4379

  131. Visualization of pulse propagation with high frame rate spatial compound imaging Peer-reviewed

    Ryo Nagaoka, Genta Masuno, Kazuto Kobayashi, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　353-O-354　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-353 　

    ISSN： 1347-443X 1881-4379

  132. Observation of artherosclerosis by photoacoustic microscopy Peer-reviewed

    Mika Sato, Rena Yamazaki, Yoshihiro Hagiwara, Yuji Matsuura, Kazuto Kobayashi, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　449-O-450　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-449 　

    ISSN： 1347-443X 1881-4379

  133. Development of optical and acoustic hybrid microscope for visualization of a single cell Peer-reviewed

    Joe Shikama, Yu Sato, Kazuto Kobayashi, Koki Yoshida, Ryo Nagaoka, Yoshifumi Saijo

    Transactions of Japanese Society for Medical and Biological Engineering　52　345-O-346　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-345 　

    ISSN： 1347-443X 1881-4379

  134. 抗酸化酵素Sod1欠損マウスにおける棘上筋付着部変性の組織学的解析

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西條 芳文, 金子 和夫, 野沢 雅彦, 清水 孝彦

    JOSKAS　39　(4)　266-266　2014/07

    Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会

    ISSN： 1884-8842

  135. Coronary artery atherectomy reduces plaque shear strains: An endovascular elastography imaging study Peer-reviewed

    Zahra Keshavarz-Motamed, Yoshifumi Saijo, Younes Majdouline, Laurent Riou, Jacques Ohayon, Guy Cloutier

    ATHEROSCLEROSIS　235　(1)　140-149　2014/07

    DOI： 10.1016/j.atherosclerosis.2014.04.022 　

    ISSN： 0021-9150

    eISSN： 1879-1484

  136. Contribution of oxidative stress to the degeneration of rotator cuff entheses Peer-reviewed

    Daichi Morikawa, Yoshiaki Itoigawa, Hidetoshi Nojiri, Hirotaka Sano, Eiji Itoi, Yoshifumi Saijo, Kazuo Kaneko, Takahiko Shimizu

    JOURNAL OF SHOULDER AND ELBOW SURGERY　23　(5)　628-635　2014/05

    DOI： 10.1016/j.jse.2014.01.041 　

    ISSN： 1058-2746

  137. 超音波顕微鏡観察における金属イオン試薬添加を利用した観察法の検討(その2)

    小林和人, 山田ひかり, 別段碧, 高橋健太, 吉田祥子, 穂積直裕, 西條芳文

    超音波医学　41　S466　2014/04/15

    ISSN： 1346-1176

  138. 腱板付着部変性と酸化ストレスの関連性について 抗酸化剤を用いた検討

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西條 芳文, 金子 和夫, 野沢 雅彦, 清水 孝彦

    日本整形外科学会雑誌　88　(2)　S91-S91　2014/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  139. High Frame-Rate Estimation of Two-Dimensional Blood Flow Vector Calculated with Bidirectional Doppler Velocity

    Masuno Genta, Nagaoka Ryo, Akagawa Osamu, Sasaki Shoya, Yushizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

    BME　52　O-331-O-332　2014

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.52.O-331 　

    ISSN： 1347-443X

    More details Close

    The blood-flow can be estimated with Doppler ultrasound. However conventional ultrasound system can estimate only one-dimensional component. In this study, an aim is to estimate two-dimensional blood-flow vector by compounding two different one-dimensional components. The objective of the present study is to develop a method to obtain two-dimensional blood-flow vector by application of ultrasound Doppler technique. The two-dimensional blood-flow vector is estimated by compounding two different one-dimensional components of blood-flow vector. Each component was obtained by bidirectional Doppler ultrasound with parallel beamforming using the same probe in order to increase a frame rate. The experiment was conducted for in vivo carotid artery and a bifurcation phantom. In these experiences, two-dimensional blood-flow was observed by this technique. This work was implemented with a frame-rate of 100 Hz. We believe the method of estimating the true blood flow leads to early diagnosis of the diseases like thrombus and plaque.

  140. Measurement of Propagation Wave Velocity of Thyroid Induced by Pulsation Peer-reviewed

    Ryo Nagaoka, Shin Yoshizawa, Shin-ichiro Umemura, Yoshifumi Saijo, Kazuto Kobayashi

    2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　1136-1139　2014

    DOI： 10.1109/ULTSYM.2014.0279 　

    ISSN： 1948-5719

  141. Multiparametric Characterization of a Single Cell by an Ultrasound and Optical Combined Microscope

    Yoshifumi Saijo, Joe Shikama, Koki Yoshida, Ryo Nagaoka, Mototaka Arakawa, Kazuto Kobayashi

    2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　727-730　2014

    DOI： 10.1109/ULTSYM.2014.0179 　

    ISSN： 1948-5719

  142. Two-dimensional Blood Flow Vectors Obtained with Bidirectional Doppler Ultrasound Peer-reviewed

    Genta Masuno, Ryo Nagaoka, Aiko Omori, Yasuo Ishikawa, Osamu Akagawa, Mototaka Arakawa, Yoshifumi Saijo

    2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　5093-5096　2014

    DOI： 10.1109/EMBC.2014.6944770 　

    ISSN： 1557-170X

  143. "Sonocytometry" - Novel Diagnostic Method of Ultrasonic Differentiation of Cells in Blood Flow Peer-reviewed

    Yosuke Komatsu, Ryo Nagaoka, Ken-ichi Funamoto, Toshiyuki Hayase, Nobuo Masauzi, Hiroshi Kanai, Yoshifumi Saijo

    2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2761-2764　2014

    DOI： 10.1109/EMBC.2014.6944195 　

    ISSN： 1557-170X

  144. 腱板付着部変性における酸化ストレスの寄与 抗酸化剤による検討

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西條 芳文, 金子 和夫, 清水 孝彦

    肩関節　38　(1)　182-182　2013/09

    Publisher: (一社)日本肩関節学会

    ISSN： 0910-4461

    eISSN： 1881-6363

  145. 腱板骨付着部変性における酸化ストレスの寄与

    森川 大智, 清水 孝彦, 糸魚川 善昭, 川崎 隆之, 金子 和夫, 佐野 博高, 井樋 栄二, 西條 芳文

    肩関節　37　(2)　825-828　2013/09

    Publisher: (一社)日本肩関節学会

    ISSN： 0910-4461

    eISSN： 1881-6363

  146. Projection Mode Ulrasonic Microscopy for Cell-size Observation Peer-reviewed

    Agus Indra Gunawan, Naohiro Hozumi, Tomohide Furuhashi, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo, Seiji Yamamoto

    2013 Joint UFFC,EFTF and PFM Symposium(IEEE International Ultrasonics Symposium)　876-879　2013/07

    DOI： 10.1109/ULTSYM.2013.0227 　

    ISSN： 1948-5719

  147. ATP release to glutamate stimulation in rat cerebellar cortex correlated to the development of Purkinje cell dendrites and network formation Peer-reviewed

    Naohiro Hozumi, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo, Seiji Yamamoto

    the 2013 IEEE International Ultrasonics Symposium (IUS)　2013/07

  148. Sound Field Analysis for Biological Acoustic Impedance Microscope for Its Precise Calibration Peer-reviewed

    Naohiro Hozumi, Agus Indra Gunawan, Shota Kajima, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo, Seiji Yamamoto

    2013 Joint UFFC,EFTF and PFM Symposium(IEEE International Ultrasonics Symposium)　1204-1207　2013/07

    DOI： 10.1109/ULTSYM.2013.0310 　

    ISSN： 1948-5719

  149. Ultrasonic Measurement of Microdisplacement Induced by Acoustic Radiation Force Peer-reviewed

    Ryo Nagaoka, Takuya Izumi, Yosuke Komatsu, Kazuto Kobayashi, Yoshifumi Saijo

    JAPANESE JOURNAL OF APPLIED PHYSICS　52　(7)　07HF21　2013/07

    DOI： 10.7567/JJAP.52.07HF21 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  150. スクリーニング心エコーで発見された大動脈弁輪部膿瘍の一症例

    藤原 淳子, 小泉, 真澄, 遠藤, 洋一, 佐々木, 聖子, 大沼, 秀知, 三木, 俊, 西條, 西條 芳文, 秋山, 正年, 齋木 佳克

    超音波医学　40　(3)　306-306　2013/05

    Publisher:

    ISSN： 1346-1176

    eISSN： 1881-9311

  151. New Concept of Pathology - Mechanical Properties Provided by Acoustic Microscopy Peer-reviewed

    Yoshifumi Saijo

    Advances in Acoustic Microscopy and High Resolution Imaging: From Principles to Applications　187-206　2013/04/12

    Publisher: Wiley-VCH

    DOI： 10.1002/9783527655304.ch8 　

  152. 光音響イメージングによる軟骨-骨複合体における変形性膝関節症の評価

    和泉 拓哉, 長岡 亮, 佐藤 みか, 萩原 嘉廣, 矢部 裕, 西條 芳文

    超音波医学　40　(Suppl.)　S629-S629　2013/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  153. 腱板付着部変性における酸化ストレスの関与

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西条 芳文, 川崎 隆之, 金子 和夫, 清水 孝彦

    日本整形外科学会雑誌　87　(3)　S688-S688　2013/03

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  154. Tele-Echographic Image Archiving System Using a Tablet Computer and a Virtual Probe

    Sugita Norihiro, Yoshizawa Makoto, Abe Makoto, Homma Noriyasu, Yambe Tomoyuki, Saijo Yoshifumi

    BME　51　M-10-M-10　2013

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.51.M-10 　

    ISSN： 1347-443X

  155. Recent applications of acoustic microscopy for quantitative measurement of acoustic properties of soft tissues Peer-reviewed

    Yoshifumi Saijo

    Quantitative Ultrasound in Soft Tissues　291-314　2013/01/01

    Publisher: Springer Netherlands

    DOI： 10.1007/978-94-007-6952-6_12 　

  156. Three-dimensional imaging of the vasculature in chicken embryo by combination of ultrasonic and photoacoustic imaging Peer-reviewed

    Mika Sato, Takuya Izumi, Yoshifumi Saijo, Yuji Watanabe, Harukazu Nakamura

    IEEE International Ultrasonics Symposium, IUS　1532-1533　2013

    DOI： 10.1109/ULTSYM.2013.0389 　

    ISSN： 1948-5719 1948-5727

  157. Acoustic characteristics of fatty and fibrotic liver measured by an 80-MHz and 250 MHz scanning acoustic microscopy Peer-reviewed

    Tadashi Yamaguchi, Kenta Inoue, Kenji Yoshida, Satoki Zenbutsu, Hitoshi Maruyama, Jonathan Mamou, Kazuto Kobayashi, Yoshifumi Saijo

    IEEE International Ultrasonics Symposium, IUS　393-396　2013

    DOI： 10.1109/ULTSYM.2013.0102 　

    ISSN： 1948-5719 1948-5727

  158. Speed of sound of fatty and fibrosis liver measured by 80-MHz and 250MHz scanning acoustic microscopy Peer-reviewed

    Tadashi Yamaguchi, Kenta Inoue, Jonathan Mamou, Kazuto Kobayashi, Yoshifumi Saijo

    Proceedings of Meetings on Acoustics　19　2013

    DOI： 10.1121/1.4800375 　

    ISSN： 1939-800X

  159. Multimodal ultrasound microscopy for biomedical imaging Peer-reviewed

    Yoshifumi Saijo

    Proceedings of Meetings on Acoustics　19　2013

    DOI： 10.1121/1.4800342 　

    ISSN： 1939-800X

  160. A New diagnostic feasibility for cardiomyopathy utilizing acoustic microscopy Peer-reviewed

    Youichi Nakamura, Kengo, Fukushima Kusano, Kazufumi Nakamura, Kazuto Kobayashi, Naohiro Hozumi, Yoshifumi Saijo, Tohru Ohe

    World Journal of Cardiovascular Diseases,2013,3,22-30 doi:10.4236/wjcd.2012.31006 Published Online January 2013　2013

    DOI： 10.4236/wjcd.2012.31006 　

  161. Validation of Echo-Dynamography by virtual color doppler echocardiography generated from phase contrast magnetic resonance angiography datasets Peer-reviewed

    Takanori Kojima, Aiko Omori, Hiroyuki Nakajima, Takafumi Kurokawa, Takeyoshi Kameyama, Yoshifumi Saijo

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　105-108　2013

    DOI： 10.1109/EMBC.2013.6609448 　

    ISSN： 1557-170X

  162. Relation between morphology of sebaceous glands inside human skin and viscoelastic properties Peer-reviewed

    Ryo Nagaoka, Kazuto Kobayashi, Yoshifumi Saijo

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　1112-1115　2013

    DOI： 10.1109/EMBC.2013.6609700 　

    ISSN： 1557-170X

  163. Ultrasonic and photoacoustic imaging of knee joints in normal and osteoarthritis rats. Peer-reviewed

    Takuya Izumi, Mika Sato, Yutaka Yabe, Yoshihiro Hagiwara, Yoshifumi Saijo

    Conf Proc 35th IEEE Eng Med Biol Soc　1116-1119　2013

    DOI： 10.1109/EMBC.2013.6609701 　

  164. The role of oxidative stress on degeneration of rotator cuff enthesis Peer-reviewed

    Daichi Morikawa, Yoshiaki Itoigawa, Hidetoshi Nojiri, Hirotaka Sano, Eiji Itoi, Yoshifumi Saijo, Takayuki Kawasaki, Kazuo Kaneko, Takahiko Shimizu

    Journal of Shoulder and Elbow Surgery　21　(12)　e25　2012/12

    DOI： 10.1016/j.jse.2012.10.004 　

    ISSN： 1058-2746 1532-6500

  165. A FOUR-CRITERION SELECTION PROCEDURE FOR ATHEROSCLEROTIC PLAQUE ELASTICITY RECONSTRUCTION BASED ON IN VIVO CORONARY INTRAVASCULAR ULTRASOUND RADIAL STRAIN SEQUENCES Peer-reviewed

    Simon Le Floc'h, Guy Cloutier, Yoshifumi Saijo, Gerard Finet, Saami K. Yazdani, Flavien Deleaval, Gilles Rioufol, Roderic I. Pettigrew, Jacques Ohayon

    ULTRASOUND IN MEDICINE AND BIOLOGY　38　(12)　2084-2097　2012/12

    DOI： 10.1016/j.ultrasmedbio.2012.07.021 　

    ISSN： 0301-5629

  166. 小児人工肺動脈弁機能評価のための新しい右心系模擬循環回路開発

    坪子 侑佑, 鈴木, 一郎, 白石, 泰之, 山田, 昭博, 松尾, 諭志, 三浦, 英和, 西條, 西條 芳文, 馮, 忠剛, 阿久津, 敏乃介, 梅津, 光生, 齋木, 佳克, 山家, 智之, 宮崎, 隆子, 山岸 正明

    人工臓器　41　(2)　S-148　2012/11

    Publisher:

    ISSN： 0300-0818

    eISSN： 1883-6097

  167. 極細形状記憶合金線維の多層化による人工心筋システムの改良

    白石 泰之, 早津, 幸弘, 秋山, 正年, 北野, 智哉, 山田, 昭博, 坪子, 侑佑, 中島, 博行, 庄内, 千紘, 柏, 公一, 西條, 西條 芳文, 齋木, 佳克, 本間, 大, 山家 智之

    人工臓器　41　(2)　S-135　2012/11

    Publisher:

    ISSN： 0300-0818

    eISSN： 1883-6097

  168. Application of a Telemedical Tool in an Isolated Island and a Disaster Area of the Great East Japan Earthquake Invited Peer-reviewed

    Makoto Yoshizawa, Tomoyuki Yambe, Norihiro Sugita, Satoshi Konno, Makoto Abe, Noriyasu Homma, Futoshi Takei, Katsuhiko Yokota, Yoshifumi Saijo, Shin-ichi Nitta

    IEICE Transactions on Communication　E95-B　(10)　3067-3073　2012/10

    Publisher: The Institute of Electronics, Information and Communication Engineers

    DOI： 10.1587/transcom.E95.B.3067 　

    ISSN： 0916-8516

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    The present paper has reported a case study of the "Electronic Doctor's Bag" which is a telemedical tool for home-visit medical services using the mobile communications environment in an isolated island and a disaster area hit by the tsunami. Clinical trials performed for 20 patients around a clinic in Miyako Island indicated that the communication functions of the proposed system were highly evaluated by patients as well as medical staffs. However, the system still has room for further improvement in operability, portability and mobile communication environment. The experience at the shelter in Kesennuma City suggested that mobile healthcare tools such as the proposed system will be strongly required when there are no or only paramedical staffs after leaving of emergency medical staffs.

  169. HIGH-RESOLUTION ULTRASOUND IMAGING OF HUMAN SKIN IN VIVO BY USING THREE-DIMENSIONAL ULTRASOUND MICROSCOPY Peer-reviewed

    Kazutoshi Kumagai, Hideyuki Koike, Ryo Nagaoka, Shingo Sakai, Kazuto Kobayashi, Yoshifumi Saijo

    ULTRASOUND IN MEDICINE AND BIOLOGY　38　(10)　1833-1838　2012/10

    DOI： 10.1016/j.ultrasmedbio.2012.05.012 　

    ISSN： 0301-5629

  170. 腱板付着部変性における酸化ストレスの寄与

    森川 大智, 糸魚川 善昭, 野尻 英俊, 佐野 博高, 井樋 栄二, 西条 芳文, 川崎 隆之, 金子 和夫, 清水 孝彦

    肩関節　37　(1)　248-248　2012/09

    Publisher: (一社)日本肩関節学会

    ISSN： 0910-4461

    eISSN： 1881-6363

  171. Telemedicine System Necessary in Disaster Areas Peer-reviewed

    Norihiro Sugita, Makoto Yoshizawa, Hitoshi Kawata, Tomoyuki Yambe, Satoshi Konno, Yoshifumi Saijo, Makoto Abe, Noriyasu Homma, Shin-ichi Nitta

    Proc. of the SICE Annual Conference 2012　1661-1664　2012/08/20

  172. Chondrogenic, inflammatory and fibrotic process in pathology of idiopathic frozen shoulders Peer-reviewed

    Y. Hagiwara, A. Ando, Y. Onoda, T. Takemura, T. Minowa, N. Hanagata, M. Tsuchiya, Y. Saijo, E. Itoi

    Osteoarthritis and Cartilage　20　S247　2012/04

    Publisher: Elsevier {BV}

    DOI： 10.1016/j.joca.2012.02.411 　

  173. Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders Peer-reviewed

    Y. Hagiwara, A. Ando, Y. Onoda, T. Takemura, T. Minowa, N. Hanagata, M. Tsuchiya, T. Watanabe, E. Chimoto, H. Suda, N. Takahashi, H. Sugaya, Y. Saijo, E. Itoi

    Osteoarthritis and Cartilage　20　(3)　241-249　2012/03

    DOI： 10.1016/j.joca.2011.12.008 　

    ISSN： 1063-4584

    eISSN： 1522-9653

  174. Evaluation of the implant type tissue-engineered cartilage by scanning acoustic microscopy Peer-reviewed

    Yoko Tanaka, Yoshifumi Saijo, Yuko Fujihara, Hisayo Yamaoka, Satoru Nishizawa, Satoru Nagata, Toru Ogasawara, Yukiyo Asawa, Tsuyoshi Takato, Kazuto Hoshi

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　113　(2)　252-257　2012/02

    DOI： 10.1016/j.jbiosc.2011.10.011 　

    ISSN： 1389-1723

  175. Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function

    Ichiro Suzuki, Yasuyuki Shiraishi, Shota Yabe, Yusuke Tsuboko, Telma Keiko Sugai, Ken Matsue, Takeyoshi Kameyama, Yoshifumi Saijo, Takashi Tanaka, Yoshihiro Okamoto, Zhonggang Feng, Takako Miyazaki, Masaaki Yamagishi, Makoto Yoshizawa, Mitsuo Umezu, Tomoyuki Yambe

    JOURNAL OF ARTIFICIAL ORGANS　15　(1)　49-56　2012

    DOI： 10.1007/s10047-011-0609-1 　

    ISSN： 1434-7229

  176. Photoacoustic Imaging of Rat Knee Joint Peer-reviewed

    Takuya Izumi, Mika Sato, Yoshihiro Hagiwara, Yoshifumi Saijo

    2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　1417-1420　2012

    DOI： 10.1109/ULTSYM.2012.0354 　

  177. Elasticity of Artificial Skin by Measuring Displacement Induced by Acoustic Radiation Force Peer-reviewed

    Ryo Nagaoka, Takuya Izumi, Kiyono Kubo, Kazuto Kobayashi, Yoshifumi Saijo

    2012 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　1378-1381　2012

    DOI： 10.1109/ULTSYM.2012.0344 　

  178. Sound Speed Measurement in Prostatic Cancer by Ultrasound Speed Microscope Peer-reviewed

    Hideki Tanoue, Youji Urata, Yoshihiro Hagiwara, Yoshifumi Saijo

    ACOUSTICAL IMAGING, VOL 31　31　331-337　2012

    DOI： 10.1007/978-94-007-2619-2_32 　

    ISSN： 0270-5117

  179. Observasion of Rat Brain Tumor Model and Its Quantitative Analysis by Acoustic Impedance Microscopy Peer-reviewed

    N.Hozumi, S.Yoshida, K.Kobayashi, Y.Saijo, K.Miura, S.Yamamoto

    2012 IEEE International Ultrasonics Symposium　2012

    Publisher: IEEE

    DOI： 10.1109/ULTSYM.2012.0593 　

  180. Color Dependence of Photoacoustic Micro Imaging Peer-reviewed

    Saijo Yoshifumi, Koike Hideyuki, Izumi Takuya, Miida Yusuke, Matsuura Yuji, Hozumi Naohiro

    ACOUSTICAL IMAGING, VOL 31　31　323-329　2012

    DOI： 10.1007/978-94-007-2619-2_31 　

    ISSN： 0270-5117

  181. Echogenicity in transrectal ultrasound is determined by sound speed of prostate tissue components. Peer-reviewed

    Hideki Tanoue, Yoshihiro Hagiwara, Kazuto Kobayashi, Yoshifumi Saijo

    Conf Proc 34th IEEE Eng Med Biol Soc　460-463　2012

    DOI： 10.1109/EMBC.2012.6345967 　

  182. Evaluation of Vortex Flow in Left Ventricle by Echo-dynamography and Phase Contrast Magnetic Resonance Angiography Peer-reviewed

    Takanori Kojima, Takeyoshi Kameyama, Hiroyuki Nakajima, Elena Khmyrova, Takafumi Kurokawa, Yoshifumi Saijo

    2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2676-2679　2012

    ISSN： 1557-170X

  183. Comparison of articular cartilage images assessed by high-frequency ultrasound microscope and scanning acoustic microscope. International-journal Peer-reviewed

    Yoshihiro Hagiwara, Yoshifumi Saijo, Akira Ando, Yoshito Onoda, Hideaki Suda, Eiichi Chimoto, Kouki Hatori, Eiji Itoi

    International orthopaedics　36　(1)　185-90　2012/01

    DOI： 10.1007/s00264-011-1263-1 　

    More details Close

    PURPOSE: The purpose of this study was to compare images of a newly developed high-frequency ultrasound imaging system (HFUIS) and scanning acoustic microscope (SAM) and to calculate their Pearson product moment correlations with a view to applying HFUIS for clinical use. METHODS: Cylindrical cartilage-bone complexes from adult male Sprague-Dawley rats were obtained. The specimens were immersed in normal saline and scanned by HFUIS. Intensity by HFUIS was normalised by reflection from a steel plate at the same distance. After the scanning, specimens were fixed with paraformaldehyde, decalcified and embedded in paraffin. Thinly sliced tissues were prepared for SAM evaluation. After the scanning, three layers of articular cartilage (superficial, middle and deep) were independently evaluated and their relationships calculated. RESULTS: The superficial and deep layers indicated high relative intensity, whereas the middle layer showed nonhomogeneous relative intensity by HFUIS. A high relative intensity by HFUIS and high sound speed area by SAM had strong correlations (Pearson product moment correlation, superficial layer 0.704, middle layer 0.731). CONCLUSIONS: HFUIS produced high-resolution images of the articular cartilage and its intensity was strongly correlated with sound speed by SAM.

  184. 生体僧房弁モデルを用いた力学検討に基づく人工乳頭筋設計 Peer-reviewed

    橋本尚, 白石泰之, SugaiTelma, 志賀卓弥, 神谷蔵人, HashemMohamed, 北野智哉, 古賀千尋, 陳炯旬, 山田昭博, 坪子侑佑, 森谷葵, 三浦英和, 西條芳文, 山家智之, 本間大

    人工臓器　40　(2)　S138-S138　2011/10

    ISSN： 0300-0818

  185. 小児用新型肺動脈人工弁設計における最適化のための新しい設計の基礎検討 Peer-reviewed

    坪子侑佑, 鈴木一郎, 白石泰之, SugaiTelma Keiko, 北野智哉, 山田昭博, 志賀卓弥, 神谷蔵人, 劉江箭, 三浦英和, 西條芳文, 山家智之, 松尾諭志, 齋木佳克, 梅津光生, 宮崎隆子, 山岸正明

    人工臓器　40　(2)　S118-S118　2011/10

    ISSN： 0300-0818

  186. 日本発の人工臓器技術 スマートアクチュエータを利用した人工心筋 Peer-reviewed

    白石泰之, 秋山正年, 西條芳文, SugaiTelma Keiko, 北野智哉, 金子芳一, OmranMohamed Hashem, 山田昭博, 三浦英和, 志賀卓弥, 神谷蔵人, 森田紀代造, 山岸正明, TozziPiergiorgio, 梅津光生, 本間大, 齋木佳克, 山家智之

    人工臓器　40　(2)　S26-S26　2011/10

    ISSN： 0300-0818

  187. 音響インピーダンス顕微鏡による脳腫瘍の観察と相関解析

    鈴木貴也, 花井邦彦, 依田正之, 小林和人, 山本清二, 西條芳文, 穂積直裕, 吉田祥子

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2011　ROMBUNNO.K4-7　2011/09/20

  188. 音響インピーダンス顕微鏡による培養細胞の3次元形状観察

    花井邦彦, 鈴木貴也, 依田正之, 小林和人, 山本清二, 西條芳文, 穂積直裕, 吉田祥子

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2011　ROMBUNNO.K4-6　2011/09/20

  189. 生物用音響インピーダンス顕微鏡による培養細胞の3次元形状観察

    花井邦彦, 植村努, 鈴木貴也, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2011　(1)　186　2011/03/05

  190. 音響インピーダンス顕微鏡による脳腫瘍の観察とフーリエ解析

    鈴木貴也, 植村努, 花井邦彦, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2011　(1)　185　2011/03/05

  191. Location of flow axis line in the left ventricle and its interaction with local myocardial motion Peer-reviewed

    Hiroyuki Nakajima, Shigeo Sugawara, Takeyoshi Kameyama, Haruna Tabuchi, Shigeo Ohtsuki, Motonao Tanaka, Yoshifumi Saijo

    Journal of Echocardiography　9　(1)　24-29　2011/03

    DOI： 10.1007/s12574-010-0067-4 　

    ISSN： 1349-0222 1880-344X

  192. Numerical Analysis of Effects of Measurement Errors on Ultrasonic-Measurement-Integrated Simulation Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING　58　(3)　653-663　2011/03

    DOI： 10.1109/TBME.2010.2095418 　

    ISSN： 0018-9294

  193. 光ファイバを用いたレーザ誘起超音波顕微鏡に関する基礎的研究

    三井田 佑輔, 小池 秀幸, 西條 芳文, 松浦 祐司

    電気関係学会東北支部連合大会講演論文集　2011　296-296　2011

    Publisher: 電気関係学会東北支部連合大会実行委員会

    DOI： 10.11528/tsjc.2011.0_296 　

  194. High Frequency Ultrasound Imaging of Cartilage-Bone Complex Peer-reviewed

    Y. Hagiwara, Y. Saijo, A. Ando, K. Kobayashi, A. Tanaka, N. Hozumi, K. Hatori, E. Itoi

    ACOUSTICAL IMAGING, VOL 30　30　118-123　2011

    DOI： 10.1007/978-90-481-3255-3_15 　

    ISSN： 0270-5117

  195. Visualization of Microvessels in Skin by Three-Dimensional Ultrasound Microscope Peer-reviewed

    Y. Saijo, K. Kobayashi, N. Hozumi, A. Tanaka, S. Sakai

    ACOUSTICAL IMAGING, VOL 30　30　107-112　2011

    DOI： 10.1007/978-90-481-3255-3_13 　

    ISSN： 0270-5117

  196. IVUS Is Still Alive - Multi Parameter Analysis for Tissue Characterization of Coronary Atherosclerosis and Interpretation from Acoustic Microscopy Observation Peer-reviewed

    Yoshifumi Saijo

    2011 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)　2005-2008　2011

    DOI： 10.1109/ULTSYM.2011.0499 　

    ISSN： 1948-5719

  197. Color-dependent photoacoustic effect for biomedical functional imaging Peer-reviewed

    Yoshifumi Saijo, Hideyuki Koike, Takuya Izumi, Yusuke Miida, Yuji Matsuura, Naohiro Hozumi

    Proceedings of Forum Acusticum　45-48　2011

    ISSN： 2221-3767

  198. Imaging of Sebaceous Glands of Human Skin by Three-dimensional Ultrasound Microscopy and Its Relation to Elasticity Peer-reviewed

    Kazutoshi Kumagai, Hideyuki Koike, Yukina Kudo, Ryo Nagaoka, Kiyono Kubo, Kazuto Kobayashi, Yoshifumi Saijo

    2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　7199-7202　2011

    ISSN： 1557-170X

  199. Ultrasonic tissue characterization of prostate biopsy tissues by ultrasound speed microscope. Peer-reviewed

    Hideki Tanoue, Yoshihiro Hagiwara, Kazuto Kobayashi, Yoshifumi Saijo

    Conf Proc 33rd IEEE Eng Med Biol Soc　8499-8502　2011

    DOI： 10.1109/IEMBS.2011.6092097 　

  200. Reversibility of immobilization-induced articular cartilage degeneration after remobilization in rat knee joints Peer-reviewed

    Akira Ando, Hideaki Suda, Yoshihiro Hagiwara, Yoshito Onoda, Eiichi Chimoto, Yoshifumi Saijo, Eiji Itoi

    Tohoku Journal of Experimental Medicine　224　(2)　77-85　2011

    DOI： 10.1620/tjem.224.77 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  201. 棘上筋腱骨停止部の変性と物理特性 超音波顕微鏡による計測

    佐野 博高, 糸魚川 善昭, 篠崎 晋久, 迫間 巧将, 山本 宣幸, 井樋 栄二, 西條 芳文, Uhthoff Hans K., Trudel Guy

    肩関節　35　(1)　51-51　2010/09

    Publisher: (一社)日本肩関節学会

    ISSN： 0910-4461

    eISSN： 1881-6363

  202. Enthesisの基礎 構造と機能 棘上筋腱骨付着部の物理特性 超音波顕微鏡による計測 Peer-reviewed

    佐野博高, 服部弘之, 峯田光能, 井樋栄二, 西條芳文

    日本整形外科学会雑誌　84　(9)　567-570　2010/09

  203. 電子診療鞄の展開と評価 Peer-reviewed

    杉田典大, 吉澤誠, 山家智之, 西條芳文, 金野敏, 仁田新一

    日本遠隔医療学会雑誌　6　(2)　207-210　2010/09

    Publisher:

    ISSN： 1880-800X

  204. Effect of Measurement Error on Ultrasonic-Measurement-Integrated Simulation of Blood Flow in an Aortic Aneurysm

    K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

    Proceedings of the 13th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　80-83　2010/08/04

  205. 棘上筋腱骨停止部の組織学的変性と物理特性 超音波顕微鏡による計測 Peer-reviewed

    佐野博高, 糸魚川善昭, 篠崎晋久, 迫間巧将, 山本宣幸, 井樋栄二, 西條芳文, TrudelGuy, UhthoffHans K

    日本整形外科学会雑誌　84　(8)　S1222-S1222　2010/08

    Publisher:

    ISSN： 0021-5325

  206. Effect of deposition time on film thickness and their properties for hydrothermally-grown epitaxial KNbO3 thick films Peer-reviewed

    Mutsuo Ishikawa, Hiro Einishi, Mitsumasa Nakajima, Tomohito Hasegawa, Takeshi Morita, Yoshifumi Saijo, Minoru Kurosawa, Hiroshi Funakubo

    Japanese Journal of Applied Physics　49　(7)　2010/07

    DOI： 10.1143/JJAP.49.07HF01 　

    ISSN： 0021-4922 1347-4065

  207. Effect of estrogen on tissue elasticity of the ligament proper in rabbit anterior cruciate ligament: measurements using scanning acoustic microscopy. Peer-reviewed

    Hattori Koshi, Sano Hirotaka, Komatsuda Tatsuro, Saijo Yoshifumi, Sugita Takehiko, Itoi Eiji

    J Orthop Sci　15　(4)　584-588　2010/07

    DOI： 10.1007/s00776-010-1474-0 　

    ISSN： 0949-2658

  208. Brief Effect of Acupuncture on the Peripheral Arterial System of the Upper Limb and Systemic Hemodynamics in Humans Peer-reviewed

    Shin Takayama, Takashi Seki, Masashi Watanabe, Yasutake Monma, San Yue Yang, Norihiro Sugita, Satoshi Konno, Yoshifumi Saijo, Tomoyuki Yambe, Nobuo Yaegashi, Makoto Yoshizawa, Shin-ichi Nitta

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE　16　(7)　707-713　2010/07

    DOI： 10.1089/acm.2009.0355 　

    ISSN： 1075-5535

    eISSN： 1557-7708

  209. A-V-V-Aパターンでのみ誘発されたnarrow QRS tachycardiaの1例

    田渕 晴名, 山中 多聞, 河部 周子, 山口 済, 山家 実, 中野 陽夫, 菅原 重生, 片平 美明, 西條 芳文, 山家 智之

    Journal of Arrhythmia　26　(Suppl.)　279-279　2010/04

    Publisher: (一社)日本不整脈心電学会

    ISSN： 1880-4276

    eISSN： 1883-2148

  210. 3次元逆畳込による生物用音響インピーダンス顕微鏡の収差補正と評価

    植村努, 鈴木貴也, 花井邦彦, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2010　(1)　152　2010/03/05

  211. RADIAL ARTERY HEMODYNAMIC CHANGES RELATED TO ACUPUNCTURE Peer-reviewed

    Shin Takayama, Takashi Seki, Norihiro Sugita, Satoshi Konno, Hiroyuki Arai, Yoshifumi Saijo, Tomoyuki Yambe, Nobuo Yaegashi, Makoto Yoshizawa, Shin-ichi Nitta

    EXPLORE-THE JOURNAL OF SCIENCE AND HEALING　6　(2)　100-105　2010/03

    DOI： 10.1016/j.explore.2009.12.001 　

    ISSN： 1550-8307

    eISSN： 1878-7541

  212. Improvement of High Frequency Ultrasound Imaging Qality by Considering Beam Propagation Peer-reviewed

    Minami Ogawa, Yoshifumi Saijo, Kazuto Kobayashi, Takahiro Iwamoto, Hideyuki Koike, Kazutoshi Kumagai, Akira Tanaka, Makoto Yoshizawa

    5th International Symposium on Medical, Bio- and Nano-Electronics　2010/02

  213. Ultrasonic Measurement of Micro-acoustic Properties of the Biological Soft Materials Peer-reviewed

    Yoshifumi Saijo

    Advanced Ultrasonic Methods for Material and Structure Inspection　89-113　2010/01/27

    Publisher: ISTE

    DOI： 10.1002/9780470612248.ch3 　

  214. 超音波顕微鏡を利用したラット下顎頭軟骨弾性の経時的変化

    羽鳥 弘毅, 萩原 嘉廣, 西條 芳文, 安藤 晃, 伊奈 慶典, 安藤 浩二, 白石 成, 佐藤 奨, 佐々木 啓一

    日本補綴歯科学会誌　2　(1)　E19-E19　2010/01

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  215. Effect of measurement error on ultrasonic-measurement-integrated simulation of blood flow in an aortic aneurysm Peer-reviewed

    K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

    IFMBE Proceedings　31　1652-1655　2010

    DOI： 10.1007/978-3-642-14515-5_420 　

    ISSN： 1680-0737

  216. Tangible modelling of ventricular aneurysm Peer-reviewed

    Y. Shiraishi, S. Yabe, H. Lin, T. K. Sugai, Y. Saijo, T. Fujimoto, M. Umezu, T. Yambe, Y. Saiki, K. Tabayashi

    IFMBE Proceedings　31　469-472　2010

    DOI： 10.1007/978-3-642-14515-5_120 　

    ISSN： 1680-0737

  217. Cross-sectional observation of rat brain tumor model and its quantitative analysis by newly proposed acoustic microscope Peer-reviewed

    Naohiro Hozumi, Takaya Suzuki, Tsutomu Uemura, Katsutoshi Miura, Kazuto Kobayashi, Sachiko Yoshida, Masayuki Nagao, Yoshifumi Saijo, Seiji Yamamoto

    International Journal of Computer Assisted Radiology and Surgery　5　(1)　S317-S318　2010

  218. A Mobile Communications System for Home-Visit Medical Services: The Electronic Doctor's Bag Peer-reviewed

    Makoto Yoshizawa, Tomoyuki Yambe, Satoshi Konno, Yoshifumi Saijo, Norihiro Sugita, Telma Keiko Sugai, Makoto Abe, Taro Sonobe, Yoshiaki Katahira, Shin-ichi Nitta

    2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　5496-5499　2010

    DOI： 10.1109/IEMBS.2010.5626577 　

    ISSN： 1557-170X

  219. モバイル通信を用いた電子診療鞄の開発 Peer-reviewed

    吉澤誠, 山家智之, 西條芳文, 金野敏

    Japanese Journal of Telemedicine and Telecare　5　(2)　182-183　2009/10

  220. Acoustic microscopy: latest developments and applications. Invited Peer-reviewed

    Saijo Y

    Imaging in Medicine　1　(1)　47-63　2009/10

  221. 3次元逆畳込による生物用音響インピーダンス顕微鏡の収差補正

    植村努, 中野愛子, 花井邦彦, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2009　ROMBUNNO.O-232　2009/09/07

  222. 生体組織用音響インピーダンス顕微鏡によるラットの脳腫瘍モデルの観察と定量解析

    鈴木貴也, 植村努, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2009　ROMBUNNO.O-231　2009/09/07

  223. Hemodynamic response with an artificial myocardial assistance in chronic animal, examination Peer-reviewed

    Y. Shiraishi, T. Yambe, Y. Saijo, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, A. Baba T, Fujimoto K, Imachi M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, Y. Sato, M, Umezu D, Hom

    WC 2009, IFMBE Proceedings　25　(8)　277-280　2009/09

    DOI： 10.1007/978-3-642-03887-7-80 　

  224. Analysis of baroreflex sensitivity during undulation pump ventricular assist device support. Peer-reviewed

    Liu Hongjian, Shiraishi Yasuyuki, Zhang Xiumin, Song Hojin, Saijo Yoshifumi, Baba Atsushi, Yambe Tomoyuki, Abe Yusuke, Imachi Kou

    Artif Organs　33　(7)　561-565　2009/07

    DOI： 10.1111/j.1525-1594.2009.00738.x 　

  225. Reproduction of Blood Flow Field by Numerical Simulation Integrated with Ultrasonic Measurement with Noise

    K. Funamoto, T. Hayase, Y. Saijo, T. Yambe

    Proceedings of the ASME 2009 Summer Bioengineering Conference　2009/06/18

    DOI： 10.1115/SBC2009-206596 　

  226. Effect of Aliasing on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow

    K. Funamoto, T. Hayase, K. Imagawa, Y. Saijo, T. Yambe

    Proceedings of the 10th International Symposium of 2007 Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”　18-19　2009/04/17

  227. Assessment of synchronization measures for effective ventricular support by using the shape memory alloy fibred artificial myocardium in goats. Peer-reviewed

    Shiraishi Y, Yambe T, Saijo Y, Sato F, Tanaka A, Yoshizawa M, Sugai T K, Kaneko Y, Sato Y, Uematsu M, Umezu M, Fujimoto T, Masumoto N, Liu H, Baba A, Konno S, Tabayashi K, Sasada H, Homma D

    Conf Proc IEEE Eng Med Biol Soc　2009　3047-3050　2009/04

    DOI： 10.1109/IEMBS.2009.5333627 　

  228. 3次元形状観察機能を有する生物用音響インピーダンス顕微鏡

    中野愛子, 植村努, 穂積直裕, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2009　(1)　155　2009/03/17

  229. 生体組織用音響インピーダンス顕微鏡における音場計算

    植村努, 中野愛子, 高山靖章, 武本諒太, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2009　(1)　158　2009/03/17

  230. Ultrasonic intensity microscopy for imaging of living cells. International-journal Invited Peer-reviewed

    Yoshihiro Hagiwara, Yoshifumi Saijo, Akira Ando, Eiichi Chimoto, Hideaki Suda, Yoshito Onoda, Eiji Itoi

    Ultrasonics　49　(3)　386-8　2009/03

    DOI： 10.1016/j.ultras.2008.10.013 　

    More details Close

    Ultrasound intensity microscopy was developed for in vivo imaging. This paper describes the preliminary results obtained using 300 MHz ultrasound intensity microscopy for in vitro characterization of cell cultures. The novelty of the approach lies in the fact that it allows remote, non-contact and disturbance-free imaging of cultured synovial cells and the changes in the cells' properties due to external stimulants such as transforming growth factor beta-1 (TGF-beta1). The intensity imaging method has potential for extracting mechanical cell properties and monitoring the effects of drugs. Ultrasound propagates through a thin specimen such as cultured cells and is reflected at the interface between the specimen and substrate. A two-dimensional distribution of the ultrasonic intensity, which is closely related to the mechanical properties, is visualized to analyze cell organs, such as the nucleus at the central part and the cytoskeleton at the peripheral zone. After stimulation with TGF-beta1, the ultrasonic intensity at the actin zone was significantly increased compared with the control.

  231. Changes of articular cartilage after immobilization in a rat knee contracture model. International-journal Peer-reviewed

    Yoshihiro Hagiwara, Akira Ando, Eiichi Chimoto, Yoshifumi Saijo, Kaori Ohmori-Matsuda, Eiji Itoi

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society　27　(2)　236-42　2009/02

    DOI： 10.1002/jor.20724 　

    More details Close

    The objective was to determine the changes of articular cartilage of the knee joint during immobilization in a rat model. The knee joints of adult male rats were immobilized at 150 degrees of flexion using an internal fixator for 3 days, and 1, 2, 4, 8, and 16 weeks. The articular cartilage from the medial midcondylar region of the knee was obtained, divided into three areas (non-contact area, transitional area, contact area), and in each area, a degree of degeneration was evaluated by gross observation, histomorphometric grading, and measurements of thickness and number of chondrocytes. Elasticity of the articular cartilage was estimated by measuring the sound speed with use of scanning acoustic microscopy. Degeneration of the articular cartilage was mainly observed in the contact and transitional areas. Matrix staining intensity by safranin-O and number of chondrocytes were decreased in these two areas. The thickness of the articular cartilage in the non-contact and contact areas was unchanged, but it was increased in the transitional area. Decrease in sound speed was observed in the transitional area of both the femoral and tibial cartilage, indicating the softening of the articular cartilage. The changes of articular cartilage became obvious as early as 1 week after immobilization. These changes may be due to a lack of mechanical stress or a lack of joint fluid circulation during immobilization. Although we do not know the reversibility of these changes of articular cartilage, early mobilization is preferable to avoid these cartilage changes.

  232. Clinical research on the accuracy in determining the pulse wave rising point

    T. Yambe, Y. Shiraishi, Y. Saijo, H. Liu, S. Nitta, K. Imachi, A. Baba, T. Yamaguchi, S. Sugawara, Y. Katahira, N. Ohsawa, Y. Mibiki, M. Watanabe, M. Shibata, N. Sato, T. Kameyama, N. Akino, M. Munakata, M. Honda, M. Yoshizawa, N. Sugita

    Scripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae　82　(3)　164-174　2009

    ISSN： 1211-3395

  233. 超音波顕微鏡を利用したラット臼歯歯根膜弾性の経時的変化

    佐藤 奨, 萩原 嘉廣, 西條 芳文, 安藤 晃, 伊奈 慶典, 安藤 浩二, 白石 成, 羽鳥 弘毅, 佐々木 啓一

    日本補綴歯科学会誌　1　(1)　E41-E41　2009/01

    Publisher: (公社)日本補綴歯科学会

    ISSN： 1883-4426

    eISSN： 1883-6860

  234. Preliminary Study on Interactive Control for the Artificial Myocardium by Shape Memory Alloy Fibre Peer-reviewed

    R. Sakata, Y. Shiraishi, Y. Sato, Y. Saijo, T. Yambe, Y. Luo, D. Jung, A. Baba, M. Yoshizawa, A. Tanaka, T. K. Sugai, F. Sato, M. Umezu, S. Nitta, T. Fujimoto, D. Homma

    IFMBE Proceedings　23　1409-1412　2009

    DOI： 10.1007/978-3-540-92841-6_348 　

    ISSN： 1680-0737

  235. Acoustic microscopy - Beyond high resolution imaging Peer-reviewed

    Yoshifumi Saijo

    Proceedings - IEEE Ultrasonics Symposium　2009

    DOI： 10.1109/ULTSYM.2009.5441892 　

    ISSN： 1051-0117

  236. First Trial of the Chronic Animal Examination of the Artificial Myocardial Function Peer-reviewed

    Y. Shiraishi, T. Yambe, Y. Saijo, K. Matsue, M. Shibata, H. Liu, T. Sugai, A. Tanaka, S. Konno, H. Song, A. Baba, K. Imachi, M. Yoshizawa, S. Nitta, H. Sasada, K. Tabayashi, R. Sakata, Y. Sato, M. Umezu, D. Homma

    13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2268-+　2009

    ISSN： 1680-0737

  237. Aberration correction for biological acoustic impedance microscope Peer-reviewed

    Uemura T, Suzuki T, Hanai, K, Hozumi, N, Yoshida, S, Kobayashi, K, Yamamoto, S, Saijo, Y

    Ultrasonics Symposium　10.1109/ULTSYM.2009.5441436　1518-1521　2009

  238. Numerical Experiment of Transient and Steady Characteristics of Ultrasonic-Measurement-Integrated Simulation in Three-Dimensional Blood Flow Analysis Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    ANNALS OF BIOMEDICAL ENGINEERING　37　(1)　34-49　2009/01

    DOI： 10.1007/s10439-008-9600-2 　

    ISSN： 0090-6964

  239. Degenerated coracoacromial ligament in shoulders with rotator cuff tears shows higher elastic modulus: measurement with scanning acoustic microscopy Peer-reviewed

    Hiroaki Kijima, Hiroshi Minagawa, Yoshifumi Saijo, Hirotaka Sano, Tatsuru Tomioka, Nobuyuki Yamamoto, Yoichi Shimada, Kyoji Okada, Eiji Itoi

    JOURNAL OF ORTHOPAEDIC SCIENCE　14　(1)　62-67　2009/01

    DOI： 10.1007/s00776-008-1283-x 　

    ISSN： 0949-2658

  240. Quantitativeevaluation of the baroreflex sensitivity of an artery Peer-reviewed

    T. Yambe, Y. Shiraishi, Y. Saijo, H. Liu, S. Nitta, K. Imachi, A. Baba, T. Yamaguchi, S. Sugawara, Y. Katahira, N. Ohsawa, Y. Mibiki, M. Watanabe, M. Shibata, N. Sato, T. Kameyama, N. Akino, M. Munakata, M. Honada, M. Yoshizawa, N. Sugita

    SCRIPTA MEDICA (BRNO)　81　(4)　249-260　2008/12

  241. Non-contact Observation of Cultured Cells by Acoustic Impedance Microscope Peer-reviewed

    A. Nakano, T. Uemura, N. Hozumi, M. Nagao, S. Yoshida, K. Kobayashi, S. Yamamoto, Y. Saijo

    Proc. 2008 IEEE International Ultrasonics Symposium,　1893-1896　2008/11

    Publisher: IEEE

    DOI： 10.1109/ULTSYM.2008.0466 　

  242. Biomedical Application of Acoustic Microscopy Diagnosis, Assessing Echogenecity and Biomechanics Peer-reviewed

    Y. Saijo, Y. Hagiwara, K. Kobayashi, N. Okada, A.Tanaka, N. Hozumi, M. Tanaka

    Proc. 2008 IEEE International Ultrasonics Symposium　1983-1986　2008/11

    DOI： 10.1109/ULTSYM.2008.0489 　

    ISSN： 1051-0117

  243. 細胞観察のための音響インピーダンス顕微鏡の較正

    中野愛子, 高山靖章, 植村務, 穂積直裕, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2008　ROMBUNNO.O-326　2008/09/12

  244. 生体組織用音響インピーダンス顕微鏡における収差検討

    植村努, 穂積直裕, 中野愛子, 高山靖章, 武本諒太, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2008　ROMBUNNO.O-459　2008/09/12

  245. Numerical experiment for Ultrasonic-Measurement-Integrated simulation of three-dimensional unsteady blood flow Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    ANNALS OF BIOMEDICAL ENGINEERING　36　(8)　1383-1397　2008/08

    DOI： 10.1007/s10439-008-9519-7 　

    ISSN： 0090-6964

  246. Development of biological acoustic impedance microscope and its error estimation Peer-reviewed

    Hozumi Naohiro, Nakano Aiko, Terauchi Satoshi, Nagao Masayuki, Yoshida Sachiko, Kobayashi Kazuto, Yamamoto Seiji, Saijo Yoshifumi

    MODERN PHYSICS LETTERS B　22　(11)　1129-1134　2008/05/10

    DOI： 10.1142/S0217984908015954 　

    ISSN： 0217-9849

  247. 【食道疾患の臨床 update】 食道癌 食道癌ステント治療の未来 Invited Peer-reviewed

    山家智之, 白石泰之, 西條芳文, 宮田剛, 里見進, 佐藤文博, 松木英敏, 関根一光

    臨床消化器内科　23　(7)　1056-1059　2008/05

  248. 音響インピーダンス顕微鏡による培養細胞の定量評価

    中野愛子, 穂積直裕, 寺内智, 長尾雅行, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2008　(1)　155　2008/03/19

  249. 開口合成による3次元超音波顕微鏡の基礎検討

    糟谷智美, 穂積直裕, 寺内智, 長尾雅行, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2008　(1)　157　2008/03/19

  250. 生体組織用音響インピーダンス顕微鏡の較正―食塩水による精度評価―

    浜川佑也, 穂積直裕, 寺内智, 長尾雅行, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2008　(1)　156　2008/03/19

  251. 生体組織用音響インピーダンス顕微鏡の較正―集束角の影響解析と小脳組織観察―

    寺内智, 村上義信, 長尾雅行, 吉田祥子, 小林和人, 西條芳文, 穂積直裕

    電気学会全国大会講演論文集　2008　(1)　154　2008/03/19

  252. Radio Frequency Signal Analysis for Tissue Characterization of Artificial Skin Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Akira Tanaka, Makoto Yoshizawa

    11th international symposium on advanced biomedical ultrasounｄ　2008/03

  253. Numerical Evaluation of Ultrasonic-Measurement-Integrated Simulation of Blood Flow

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of 5th International Bio-Fluid Symposium and Workshop　116-117　2008/03

  254. Fractal dimension of 40 MHz intravascular ultrasound radio frequency signals Peer-reviewed

    E. Santos Filho, Y. Saijo, A. Tanaka, T. Yambe, M. Yoshizawa

    ULTRASONICS　48　(1)　35-39　2008/03

    DOI： 10.1016/j.ultras.2007.08.006 　

    ISSN： 0041-624X

  255. Recent progress of acoustic microscopy for medicine and biology

    Y. Saijo, K. Kobayashi, T. Iwamoto, N. Okada, A. Tanaka, N. Hozumi

    Proceedings - European Conference on Noise Control　93-97　2008

    ISSN： 2226-5147

  256. Engineering Support in Surgical Strategy for Ventriculoplasty Peer-reviewed

    Yasuyuki Shiraishi, T. Yambe, Y. Saijo, S. Masuda, G. Takahashi, K. Tabayashi, T. Fujimoto, M. Umezu

    IFMBE Proceedings　22　2564-2567　2008

    DOI： 10.1007/978-3-540-89208-3_615 　

    ISSN： 1680-0737

  257. ELASTIC CHANGES OF CAPSULE IN A RAT KNEE CONTRACTURE MODEL ASSESSED BY SCANNING ACOUSTIC MICROSCOPY Peer-reviewed

    Y. Hagiwara, E. Chimoto, A. Ando, Y. Saijo, E. Itoi

    ACOUSTICAL IMAGING, VOL 29　29　187-+　2008

    ISSN： 0270-5117

  258. ULTRASONIC NANO-IMAGING SYSTEM FOR MEDICINE AND BIOLOGY Peer-reviewed

    Y. Saijo, N. Hozumi, K. Kobayashi, N. Okada, Y. Hagiwara, H. Sasaki, E. D. S. Filho, T. Yambe

    ACOUSTICAL IMAGING, VOL 29　29　181-+　2008

    ISSN： 0270-5117

  259. 3次元超音波顕微鏡の開発による再生皮膚組織モデルの自動診断

    西條芳文, 萩原嘉廣, 岩本貴宏, 小林和人, 岡田長也, 田中明, 穂積直裕, 富畑賢治

    日本生体医工学会大会プログラム・論文集(CD-ROM)　47th　ROMBUNNO.FC-24-4　2008

  260. 烏口肩峰靭帯の変性と弾性との関係－超音波顕微鏡を用いた計測. Peer-reviewed

    木島泰明, 皆川洋至, 山本宣幸, 冨岡立, 阿部秀一, 菊池一馬, 島田洋一, 西條芳文, 佐野博高, 井樋栄二

    肩関節　32　233-235　2008

    DOI： 10.11296/katakansetsu.32.233 　

  261. 腱板断裂における烏口肩峰靭帯の弾性. Peer-reviewed

    木島泰明, 皆川洋至, 山本宣幸, 冨岡立, 阿部秀一, 菊池一馬, 島田洋一, 西條芳文, 佐野博高, 井樋栄二

    肩関節　32　353-356　2008

    DOI： 10.11296/katakansetsu.32.353 　

  262. Three-dimensional ultrasound imaging of regenerated skin with high frequency ultrasound. Peer-reviewed

    Yoshifumi Saijo, Yoshihiro Hagiwara, Kazuto Kobayashi, Nagaya Okada, Akira Tanaka, Naohiro Hozumi, Takahiro Iwamoto

    Proceedings of the 2008 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Paris, France, May 14-17, 2008　1231-1234　2008

    Publisher: IEEE

    DOI： 10.1109/ISBI.2008.4541225 　

  263. Sensorless Control for a Sophisticated Artificial Myocardial Contraction by using Shape Memory Alloy Fibre Peer-reviewed

    Y. Shiraishi, T. Yambe, Y. Saijo, F. Sato, A. Tanaka, A. Yoshizawa, T. K. Sugai, R. Sakata, Y. Luo, Y. Park, M. Uematsu, A. Umezu, T. Fujimoto, N. Masumoto, H. Liu, A. Baba, S. Konno, S. Nitta, K. Imachi, K. Tabayashi, H. Sasada, D. Homma

    2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8　711-+　2008

    ISSN： 1557-170X

  264. High frequency ultrasound imaging of surface and subsurface structures of fingerprints. International-journal Peer-reviewed

    Yoshifumi Saijo, Kazuto Kobayashi, Nagaya Okada, Naohiro Hozumi, Yoshihiro Hagiwara, Akira Tanaka, Takahiro Iwamoto

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2008　2173-6　2008

    DOI： 10.1109/IEMBS.2008.4649625 　

    More details Close

    High frequency ultrasound is suitable for non-invasive evaluation of skin because it can obtain both morphological and biomechanical information. A specially developed acoustic microscope system with the central frequency of 100 MHz was developed. The system was capable of (1) conventional C-mode acoustic microscope imaging of thinly sliced tissue, (2) ultrasound impedance imaging of the surface of in vivo thick tissue and (3) 3D ultrasound imaging of inside of the in vivo tissue. In the present study, ultrasound impedance imaging and 3D ultrasound imaging of in vivo fingerprints were obtained. The impedance image showed pores of the sweat glands in the surface of fingerprint and 3D ultrasound imaging showed glands of the rear surface of fingerprint. Both findings were not visualized by normal optical imaging, thus the system can be applied to pathological diagnosis of skin lesions and assessment of aging of the skin in cosmetic point of view.

  265. High frequency ultrasound characterization of artificial skin. International-journal Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Akira Tanaka, Makoto Yoshizawa

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2008　2185-8　2008

    DOI： 10.1109/IEMBS.2008.4649628 　

    More details Close

    Regenerated skin with 3-dimensional structure is desired for the treatment of large burn and for the plastic surgery. High frequency ultrasound is suitable for non-destructive testing of the skin model because it provides information on morphology and mechanical properties. In this paper, spectral parameters of ultrasound radio-frequency signal from a specially developed high-frequency ultrasound imaging system were evaluated for tissue characterization of artificial skin. Results suggest that spectral parameters are useful for classification of epidermis and dermis in the artificial skin model. The system is also a useful tool for the noninvasive and nondestructive evaluation of skin.

  266. Elasticity of the supraspinatus tendon-muscle unit is preserved after acute tendon tearing in the rabbit Peer-reviewed

    Mitsuyoshi Mineta, Hirotaka Sano, Ryogo Ichinose, Yoshifumi Saijo, Eiji Itoi

    Tohoku Journal of Experimental Medicine　216　(1)　17-24　2008

    DOI： 10.1620/tjem.216.17 　

    ISSN： 0040-8727 1349-3329

  267. Detection and quantification of calcifications in intravascular ultrasound images by automatic thresholding Peer-reviewed

    E. Santos Filho, Y. Saijo, A. Tanaka, M. Yoshizawa

    ULTRASOUND IN MEDICINE AND BIOLOGY　34　(1)　160-165　2008/01

    DOI： 10.1016/j.ultrasmedbio.2007.06.025 　

    ISSN： 0301-5629

  268. Radio Frequency Signal Analysis of Intravascular Ultrasound Aiming to Tissue Characterization of Coronary Artery by using Self Organization Map Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Akira Tanaka, Esmerald dos, Santos Filho, Shuo Li, Makoto Yoshizawa

    3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　2007/12

  269. Effect of Time Resolution of Measurement on Ultrasonic-Measurement-Integrated Simulation of Three-Dimensional Unsteady Blood Flow in an Aneurysmal Aorta

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 3rd Tohoku-NUS Joint Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region　13-16　2007/12

  270. 医工学による右心流出路再建の評価方法

    末永健, 白石泰之, 西條芳文, 山家智之, 馮忠剛, 中村孝夫, 宮崎隆子, 山岸正明, 田中隆, 岡本吉弘, 梅津光生

    人工臓器　36　(2)　S109-S109　2007/10

  271. Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes Peer-reviewed

    Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Yoshifumi Saijo, Yasuyuki Shiraishi, Takae Ebihara, Kaijun Niu, He Mei, Hiroyuki Arai, Tomoyuki Yambe

    AMERICAN JOURNAL OF PATHOLOGY　171　(4)　1093-1103　2007/10

    DOI： 10.2353/ajpath.2007.061191 　

    ISSN： 0002-9440

  272. 音響インピーダンス顕微鏡による培養細胞の非接触観察

    中野愛子, 穂積直裕, 寺内智, 長尾雅行, 吉田祥子, 小林和人, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2007　ROMBUNNO.O-288　2007/09/14

  273. 生体組織用音響インピーダンス顕微鏡の精度評価―集束角の影響解析―

    寺内智, 村上義信, 長尾雅行, 吉田祥子, 小林和人, 西條芳文, 穂積直裕

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2007　ROMBUNNO.O-287　2007/09/14

  274. 超音波音速‐インピーダンス顕微鏡によるin vivoマイクロイメージングシステム

    小林和人, 西條芳文, 穂積直裕

    日本音響学会研究発表会講演論文集(CD-ROM)　2007　1-9-13　2007/09/12

    ISSN： 1880-7658

  275. Measurement of soft tissue elasticity in the congenital clubfoot using scanning acoustic microscope Peer-reviewed

    Koshi Hattori, Hirotaka Sano, Yoshifumi Saijo, Atsushi Kita, Masahito Hatori, Shoichi Kokubun, Eiji Itoi

    JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B　16　(5)　357-362　2007/09

    DOI： 10.1097/BPB.0b013e328248b4d0 　

    ISSN： 1060-152X

  276. オプティカルフロー法による心血管内血流の可視化

    西條芳文, 田中明, 田林晄一, 山家智之

    Journal of Cardiology　50　(Suppl.I)　379-379　2007/08

  277. Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound microscanning system Peer-reviewed

    Yoshifumi Saijo, Esmeraldo Santos Filho, Hidehiko Sasaki, Tomoyuki Yambe, Motonao Tanaka, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada

    IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL　54　(8)　1571-1577　2007/08

    DOI： 10.1109/TUFFC.2007.427 　

    ISSN： 0885-3010

    eISSN： 1525-8955

  278. 脈波の立ち上がりポイント測定の正確性に関する臨床研究 Invited Peer-reviewed

    山家智之, 西條芳文, 白石泰之, 川田浩, 金野敏, 仁田新一, 山口済, 中島博行, 片平美明, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚, 秋野能久, 本多正久

    エレクトロニクスの臨床　(76)　23-34　2007/07

  279. Accuracy of Ultrasonic-Measurement-Integrated Simulation for Three-Dimensional Blood Flow in Aneurysmal Aorta Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 5th Joint ASME/JSME Fluids Engineering Conference　CD-ROM　2007/07

    DOI： 10.1115/FEDSM2007-37497 　

  280. 動脈の血圧反射機能感受性診断装置の発明 Invited

    山家智之, 川田浩, 丸山満也, 金野敏, 西條芳文, 白石泰之, 仁田新一, 吉澤誠, 杉田典大, 田中明, 宗像正徳, 山口佑, 片平美明, 秋野能久, 本多正久, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚

    東北医学雑誌　119　(1)　73-77　2007/06

  281. 形状記憶合金を用いた人工的蠕動運動型人工食道

    関根一光, 山家智之, 西條芳文, 白石泰之, 松木英敏, 佐藤文博, 前田剛, 中澤文雄

    北海道外科雑誌　52　(1)　85-85　2007/06

  282. Self-organizing map classification of coronary plaque on radio-frequency signal of intravascular ultrasound Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Akira Tanaka, Esmerald dos, Santos Filho, Shuo Li, Makoto Yoshizawa

    Paris-Sendai Symposium on Ultrasonic Tissue Characterization and Small Animal Imaging　2007/04

  283. Coronary plaque classification with intravascular ultrasound radio-frequency signal analysis using self-organizing map Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Akira Tanaka, Esmerald dos, Santos Filho, Shuo Li, Makoto Yoshizawa

    ICU 2007　2007/04

  284. Radio frequency signal analysis for tissue characterization of coronary artery: in vitro intravascular ultrasound study Peer-reviewed

    Takahiro Iwamoto, Yoshifumi Saijo, Akira Tanaka, Esmerald dos, Santos Filho, Shuo Li, Makoto Yoshizawa

    29th International Symposium on Acoustical Imaging (AI29)　2007/04

  285. 生体用音響インピーダンス顕微鏡における観察用基板表面処理の影響

    木村あゆみ, 寺内智, 正木志保, 村上義信, 長尾雅行, 吉田祥子, 小林和人, 西條芳文, 穂積直裕

    電気学会全国大会講演論文集　2007　(1)　169　2007/03/15

  286. 生体組織用音響インピーダンス顕微鏡の校正法の検討

    寺内智, 木村あゆみ, 村上義信, 長尾雅行, 吉田祥子, 小林和人, 西條芳文, 穂積直裕

    電気学会全国大会講演論文集　2007　(1)　170　2007/03/15

  287. Development of ultrasonic nano-imaging system for visualization of cells

    Yoshifumi Saijo, N. Hozumi, K. Kobayashi, N. Okada, C. K. Lee, H. Sasaki, T. Yambe, M. Tanaka

    IFMBE Proceedings　14　(1)　1409-1412　2007

    Publisher: Springer Verlag

    DOI： 10.1007/978-3-540-36841-0_345 　

    ISSN： 1433-9277 1680-0737

  288. Evaluation of Cardiac Function of the Patients with Left Ventricular Assist Device by Transesophageal Echocardiography Peer-reviewed

    Y. Saijo, Y. Saiki, A. Iguchi, K. Tabayashi, Y. Shiraishi, K. Sekine, T. Yambe

    WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2006, VOL 14, PTS 1-6　14　4146-+　2007

    ISSN： 1680-0737

  289. Development of the displacement amplification mechanism for myocardial assist device

    Watabe Tomoki, Shiraishi Yasuyuki, Wada Yumiko, Sakata Ryo, Saijo Yoshifumi, Yambe Tomoyuki, Homma Dai, Shibata Souichi, Umezu Mitsuo

    Journal of Life Support Technology　19　192-192　2007

    Publisher: The Society of Life Support Engineering

    DOI： 10.5136/lifesupport.19.Supplement_192 　

    ISSN： 1341-9455

  290. Support mechanism of a newly-designed mechanical artificial myocardium using shape memory alloy fibres

    Yasuyuki Shiraishi, T. Yambe, S. Itoh, R. Sakata, Y. Wada, K. Sekine, Y. Saijo, S. Konno, S. Nitta, Q. Wang, H. Liu, M. Higa, Y. Luo, D. Ogawa, A. Tanaka, M. Yoshizawa, Y. Kakubari, H. Miura, F. Sato, H. Matsuki, M. Uematsu, Y. Park, T. Tanaka, M. Umezu, T. Fujimoto, N. Masumoto, Y. Hori, H. Sasada, K. Tabayashi, E. Okamoto, D. Homma

    IFMBE Proceedings　14　(1)　3161-3164　2007

    DOI： 10.1007/978-3-540-36841-0_799 　

    ISSN： 1680-0737

    eISSN： 1433-9277

  291. Blood flow visualization of left atrial spontaneous echo contrast (SEC) using gradient based optical flow estimation Peer-reviewed

    Akira Tanaka, Yoshifumi Saijo

    Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings　4500-4503　2007

    DOI： 10.1109/IEMBS.2007.4353339 　

    ISSN： 0589-1019

  292. Ultrasound speed and impedance microscopy for in vivo imaging Peer-reviewed

    Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Toshimichi Ishiguro, Yoshihiro Hagiwara, Esmeraldo Dos Santos Filho, Tomoyuki Yambe

    Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings　1350-1353　2007

    DOI： 10.1109/IEMBS.2007.4352548 　

    ISSN： 0589-1019

  293. Morphological approach for the functional improvement of an artificial myocardial assist device using shape memory alloy fibres Peer-reviewed

    Y. Shiraishi, T. Yambe, Y. Saijo, F. Sato, A. Tanaka, M. Yoshizawa, D. Ogawa, Y. Wada, S. Itoh, R. Sakata, Y. Park, M. Uematsu, M. Umezu, T. Fujimoto, N. Masumoto, H. Liu, A. Baba, S. Konno, S. Nitta, K. Imachi, K. Tabayashi, H. Sasada, D. Homma

    Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings　3974-3977　2007

    DOI： 10.1109/IEMBS.2007.4353204 　

    ISSN： 0589-1019

  294. Precise calibration for biological acoustic impedance microscope Peer-reviewed

    N. Hozumi, A. Nakano, S. Terauchi, M. Nagao, S. Yoshida, K. Kobayashi, S. Yamamoto, Y. Saijo

    2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6　801-+　2007

    DOI： 10.1109/ULTSYM.2007.205 　

    ISSN： 1051-0117

  295. B-mode and C-mode imaging of regenerated 3D skin model with 100 MHz ultrasound Peer-reviewed

    Yoshifumi Saijo, Yoshihiro Hagiwara, Kazuto Kobayashi, Nagaya Okada, Akira Tanaka, Naohiro Hozumi, Kenji Tomihata

    2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6　244-+　2007

    DOI： 10.1109/ULTSYM.2007.72 　

    ISSN： 1051-0117

  296. 生体内超音波ナノ・イメージング法の開発

    西條芳文, 穂積直裕, 小林和人, DOS SANTOS FILHO Esmeraldo

    日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　ROMBUNNO.PS2-9-2　2007

  297. Numerical Realization of Blood Flow in Aneurysmal Aorta by Integrating Measurement and Simulation

    Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

    Future Medical Engineering Based on Bionanotechnology　857-868　2007

  298. Biochemical evaluation of an artificial anal sphincter made from shape memory alloys Peer-reviewed

    Hongjian Liu, Yun Luo, Masaru Higa, Xiumin Zhang, Yoshifumi Saijo, Yasuyuki Shiraishi, Kazumitsu Sekine, Tomoyuki Yambe

    JOURNAL OF ARTIFICIAL ORGANS　10　(4)　223-227　2007

    DOI： 10.1007/s10047-007-0395-y 　

    ISSN： 1434-7229

  299. Blood flow visualization of left atrial spontaneous echo contrast (SEC) using gradient based optical flow estimation Peer-reviewed

    Akira Tanaka, Yoshifumi Saijo

    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16　1　4500-+　2007

    DOI： 10.1109/IEMBS.2007.4353339 　

    ISSN： 1094-687X

  300. Morphological approach for the functional improvement of an artificial myocardial assist device using shape memory alloy fibres Peer-reviewed

    Y. Shiraishi, T. Yambe, Y. Saijo, F. Sato, A. Tanaka, A. Yoshizawa, D. Ogawa, Y. Wada, S. Itoh, R. Sakata, Y. Park, A. Uematsu, A. Umezu, T. Fujimoto, N. Masumoto, H. Liu, A. Baba, S. Konno, S. Nitta, K. Imachi, K. Tabayashi, H. Sasada, D. Homma

    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16　1　3974-3977　2007

    DOI： 10.1109/IEMBS.2007.4353204 　

    ISSN： 1094-687X

  301. Ultrasound speed and impedance microscopy for in vivo imaging Peer-reviewed

    Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Toshimichi Ishiguro, Yoshihiro Hagiwara, Esmeraldo dos Santos Filho, Tomoyuki Yambe

    2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16　1　1350-+　2007

    DOI： 10.1109/IEMBS.2007.4352548 　

    ISSN： 1094-687X

  302. Intravascular two-dimensional tissue strain imaging Peer-reviewed

    Yoshifumi Saijo, Akira Tanaka, Takahiro Iwamoto, Esmeraldo dos Santos Filho, Makoto Yoshizawa, Akira Hirosaka, Mikihiro Kijima, Yoshihisa Akino, Yasushi Hanadate, Tomoyuki Yambe

    ULTRASONICS　44　E147-E151　2006/12

    DOI： 10.1016/j.ultras.2006.06.049 　

    ISSN： 0041-624X

  303. Ultrasonic speed microscopy for imaging of coronary artery Peer-reviewed

    Yoshifumi Saijo, Naohiro Hozumi, Cheolkyou Lee, Masayuki Nagao, Kazuto Kobayashi, Nagaya Oakada, Naohiko Tanaka, Esmeraldo Dos Santos Filho, Hidehiko Sasaki, Motonao Tanaka, Tomoyuki Yambe

    ULTRASONICS　44　E51-E55　2006/12

    DOI： 10.1016/j.ultras.2006.06.050 　

    ISSN： 0041-624X

  304. Multiple parametric IVUS imagings for detection of vulnerable plaque. Peer-reviewed

    Saijo Y, Tanaka A, Santos Filho ED, Iwamoto T, Li S, Yoshizawa M, Yambe T

    Proc 9th Sendai Symposium on Ultrasonic Tissue Characterization　1　13-17　2006/11/27

  305. Classification of flow-limiting thrombus in acute coronary syndrome by acoustic microscopy Peer-reviewed

    Sasaki H, Saijo Y, Kanno T, Tanaka M

    Proc 9th Sendai Symposium on Ultrasonic Tissue Characterization　1　29-31　2006/11/27

  306. Tissue sound speed of anterior cruciate ligament in estrogen-controlled rabbits. - A measurement using the scanning acoustic microscope - Peer-reviewed

    Sano H, Hattori K, Komatsuda T, Saijo Y, Sugita T, Itoi E

    Proc 9th Sendai Symposium on Ultrasonic Tissue Characterization　1　32-35　2006/11/27

  307. Calibration for biological acoustic impedance microscope

    Naohiro Hozumi, Satoshi Terauchi, Ayumi Kimura, Masayuki Nagao, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo

    The Journal of the Acoustical Society of America　120　(5)　3111-3111　2006/11

    Publisher: Acoustical Society of America (ASA)

    DOI： 10.1121/1.4787598 　

    ISSN： 0001-4966

  308. Imaging Myocardial Heterogeneity Using Propagation of Pulsive Vibration for Patients with Old myocardial Infarction

    Hiroshi Kanai, Sachiko Watanabe, Yoshifumi Saijo, Motonao Tanaka

    Abstract From the American Heart Association's Scientific Session 2006　664-665　2006/11

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    November 12-15, 2006, Chicago, USA)

  309. Non-mineralized fibrocartilage shows the lowest elastic modulus in the rabbit supraspinatus tendon insertion: Measurement with scanning acoustic microscopy Peer-reviewed

    Hirotaka Sano, Yoshifumi Saijo, Shoichi Kokubun

    JOURNAL OF SHOULDER AND ELBOW SURGERY　15　(6)　743-749　2006/11

    DOI： 10.1016/j.jse.2005.12.008 　

    ISSN： 1058-2746

  310. Mechanical Myocardial Assistance by the Shape Memory Alloy Fibre

    SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SEKINE Kazumitsu, SAIJO Yoshifumi, KONNO Satoshi, NITTA Shin-ichi, UMEZU Mitsuo, HOMMA Dai, OKAMOTO Eiji

    電気学会研究会資料. LD, リニアドライブ研究会　2006　(48)　65-68　2006/10/26

  311. 微細機能繊維を応用した機械式人工心筋の開発 心室補助効果と血管負荷整合 Peer-reviewed

    白石泰之, 山家智之, 西條芳文, 関根一光, 小川大祐, 佐藤文博, 角張泰之, 伊藤慎二, 坂田亮, 和田由美子, 田中隆, 梅津光生, 田林晄一, 比嘉昌, 田中明, 吉澤誠, 藤本哲男, 増本憲泰, 仁田新一

    人工臓器　35　(2)　S98-S98　2006/10

    ISSN： 0300-0818

  312. 形状記憶合金を使用した蠕動運動アクチュエータの人工臓器としての可能性 Peer-reviewed

    関根一光, 白石泰之, 山家智之, 西條芳文, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

    人工臓器　35　(2)　S76-S76　2006/10

    ISSN： 0300-0818

  313. 形状記憶合金を応用した人工心筋要素の機械特性と駆動制御に関する基礎検討

    伊藤慎二, 白石泰之, 和田由美子, 坂田亮, 植松美幸, 田中隆, 小川大祐, 関根一光, 吉澤誠, 田中明, 西條芳文, 山家智之, 岡本英治, 本間大, 藤本哲男, 梅津光生

    人工臓器　35　(2)　S167-S167　2006/10

  314. 長期埋込型形状記憶合金人工括約筋の生体適合性評価

    劉紅箭, 羅雲, 比嘉昌, 西條芳文, 白石泰之, 関根一光, 山家智之

    人工臓器　35　(2)　S166-S166　2006/10

  315. 東北大学における無拍動流左心補助人工心臓EVAHEARTの長期動物実験による評価

    王慶田, 山家智之, 白石泰之, 関根一光, 西條芳文, 仁田新一, 井街宏, 山崎健二, 北野智哉, 山崎俊一

    人工臓器　35　(2)　S156-S156　2006/10

  316. 再生医療の評価方法としての高周波数超音波の可能性

    西條芳文, 白石泰之, 関根一光, 山家智之, 佐野博高, 萩原嘉広, 服部弘之, 田中明, 穂積直裕, 小林和人

    人工臓器　35　(2)　S121-S121　2006/10

  317. 音響インピーダンス顕微鏡によるラットの小脳皮質発達評価

    木村あゆみ, 寺内智, 村上義信, 長尾雅行, 吉田祥子, 穂積直裕, 小林和人, 西条芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2006　O-074　2006/09/15

  318. IVUSにおけるAttenuation Imagingの開発

    西條芳文, 田中明, サントス・フィロ・エスメラルド・ドス, 秋野能久, 花立安志, 山家智之

    Journal of Cardiology　48　(Suppl.I)　352-352　2006/09

  319. Numerical Study on Variation of Feedback Methods in Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aneurysmal Aorta Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    JSME International Journal, Series C　49　(1)　144-155　2006/09

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmec.49.144 　

    ISSN： 1344-7653

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    The complicated relationships between hemodynamics and aneurysms have been investigated intensively. However, existing methodologies have inherent limitations in providing real blood flow fields. The authors have proposed Ultrasonic-Measurement-Integrated (UMI) simulation, in which the feedback signals lead to convergence of the calculated blood flow structure to the real one even with incorrect boundary/initial conditions. In UMI simulation, determination of the feedback law is substantially important, but detailed particulars remain to be accounted for. In this paper, first, the effects of density of feedback points and feedback domains are systematically investigated. Improvement of computational accuracy in the feedback domain is achieved even in low density of feedback points of 25%, and such improvement persists in the downstream region. Secondly, the most effective combination of feedback gains for momentum and pressure equations is investigated, confirming the validity of the simple condition to use the same value for the velocity and pressure gains.

  320. Automated calcification detection and quantification in intravascular ultrasound images by adaptive threshoding Peer-reviewed

    Santos Filho E, Saijo Y, Yambe T, Tanaka A, Yoshizawa M

    Proc. of the World Congress on Medical Physics and Biomedical engineering　2006/08

  321. Improvement of Accuracy of Blood Flow Simulation by Integrating Measurement Using Ultrasonic Doppler Method

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 5th World Congress of Biomechanics　CD-ROM　2006/07

  322. Does decalcification alter the tissue sound speed of rabbit supraspinatus tendon insertion? In vitro measurement using scanning acoustic microscopy Peer-reviewed

    Hirotaka Sano, Koshi Hattori, Yoshifumi Saijo, Shoichi Kokubun

    ULTRASONICS　44　(3)　297-301　2006/07

    DOI： 10.1016/j.ultras.2006.03.002 　

    ISSN： 0041-624X

  323. Segmentation of calcification regions in intravascular ultrasound images by adaptive threshold Peer-reviewed

    Santos Filho E, Saijo Y, Yambe T, Tanaka A, Yoshizawa M

    Proc. of 19th IEEE International Symposium on Computer-based Medical Systems　446-451　2006/06

    DOI： 10.1109/CBMS.2006.142 　

  324. 人工心筋を応用した新しい機械式心臓モデル構築の試み Peer-reviewed

    白石泰之, 伊藤慎二, 山家智之, 永利潤, 西條芳文, 関根一光, 金野敏, 朴栄光, 植松美幸, 増本憲泰, 田中隆, 藤本哲男, 梅津光生, 本間大

    生体医工学　44　(2)　320-320　2006/06

  325. 蠕動運動機能を有する生体内埋め込み可能な人工食道の開発研究 Peer-reviewed

    関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博

    北海道外科雑誌　51　(1)　79-79　2006/06

    ISSN： 1347-443X

  326. Fundamental Study of Transient Characteristics of Ultrasonic-Measurement-Integrated Simulation toward Reproduction of Unsteady Blood Flows

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of ASME 2006 Summer Bioengineering Conference　CD-ROM　2006/06

  327. IVUS beyond the horizon. Invited Peer-reviewed

    van der Steen AFW, Baldewsing RA Degertekin FL Emelianov, S Frijlink ME, Furukawa Y Goertz, D Karaman, M Khuri-Yakub, PT Kim, K Mastik F, Moriya T Oralkan, O, Saijo Y, Schaar JA Serruys PW Sethuraman, S Tanaka, A Vos, HJ, Witte, R, O’Donnell M

    Eurointerv　2　132-142　2006/06

  328. 科研費研究課題の成果 ●基盤研究（B） 超音波による血管内皮細胞のナノ・イメージング Invited

    SAIJO Yoshifumi, SATO Masaaki, HOZUMI Naohiro SUZUKI Satoshi, KOBAYASHI Kazuto

    INNERVISION　21　(7)　48-48　2006/06

    Publisher:

    ISSN： 0913-8919

  329. 超音波によるナノ・イメージングの医療への応用

    西條芳文, 穂積直裕, 小林和人, SANTOS FILHO Esmeraldo Dos, 田中元直, 山家智之

    日本生体医工学会大会プログラム・論文集　45th　276　2006/05/15

    ISSN： 1347-443X

  330. Impact of Type A behavior on brachial-ankle pulse wave velocity in Japanese Peer-reviewed

    HJ Liu, Y Saijo, XM Zhang, Y Shiraishi, Y Luo, M Maruyama, M Higa, K Sekine, T Yambe

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　209　(1)　15-21　2006/05

    DOI： 10.1620/tjem.209.15 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  331. マルファン症候群に対する心臓移植の1症例 Peer-reviewed

    井口 篤志, 崔, 禎浩, 齋木, 佳克, 小田, 克彦, 赤坂, 純逸, 新田, 能郎, 川本, 俊輔, 本吉, 直孝, 安達, 理, 増田, 信也, 藤原, 英記, 吉岡, 一朗, 河津, 聡, 佐藤, 真一, 小久保, 弘晶, 田林, 晄一, 柴, 信行, 二宮, 本報, 西條 芳文

    呼吸と循環　54　(4)　S2-S3　2006/04

  332. 音響インピーダンス顕微鏡による生体組織イメージング

    木村あゆみ, 寺内智, 村上義信, 穂積直裕, 長尾雅行, 吉田祥子, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2006　(1)　141　2006/03/15

  333. Comparative analysis of cardio-ankle vascular index between Japanese and Russians Peer-reviewed

    Hongjian Liu, Yoshifumi Saijo, Xiumin Zhang, Yasuyuki Shiraishi, Kazumitsu Sekine, Mitsuya Maruyama, Yori A. Kovalev, Irina A. Milyagina, Viktor A. Milygin, Tomoyuki Yambe

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　411-+　2006

  334. Evaluation of the hemodynamic parameters during circulatory assistance using an electro-hydraulic artificial myocardium system Peer-reviewed

    Qingtian Wang, Tomoyuki Yambe, Yasuyuki Shiraishi, Kazumitsu Sekine, Yoshifumi Saijo, Shin-Ichi Nitta, Makoto Yoshizawa, Mitsuo Umezu, Kouichi Tabayashi

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　557-+　2006

  335. 637 Blood Flow Simulation Integrated with Ultrasonic Measurement : 6^<th> Report : Three-Dimensional Unsteady Blood Flow Simulation

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    The proceedings of the JSME annual meeting　2006　195-196　2006

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecjo.2006.5.0_195 　

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    Development and progress of circulatory diseases are closely related to the hemodynamics in the blood vessel. However, detailed and accurate information of blood flow field has yet to be obtained due to the limitations both in measurement and numerical simulation. Hence, we have proposed the Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured and computed Doppler velocities are fed back to the numerical simulation. The transient and steady characteristics of the UMI simulation have been revealed. In this paper, we performed the numerical experiment aiming at the reproduction of the three-dimensional unsteady flow field. As the result, the application of the feedback in the UMI simulation made the computational results converge and trace to the model of real blood flow.

  336. S-14 超音波による心臓・血管の中の流れの医工学的解析(特別企画II(要望演題5) 逆流性疾患・閉塞性疾患・拡張性疾患に対する治療戦略-管と流れと-,第43回 日本小児外科学会総会)

    西條 芳文, 白石 泰之, 関根 一光, 山家 智之, 田中 元直, 田林 晄一, 早瀬 敏幸, 船本 健一, 大槻 茂雄, 菅原 重生

    日本小児外科学会雑誌　42　(3)　355-355　2006

    Publisher: 特定非営利活動法人 日本小児外科学会

    DOI： 10.11164/jjsps.42.3_355_2 　

  337. Preliminary study on the functional reproduction of an artificial myocardium using covalent shape memory alloy fibre based on control engineering Peer-reviewed

    Yasuyuki Shiraishi, Tomoyuki Yambe, Kazumitsu Sekine, Yoshifumi Saijo, Satosni Konno, Shin-Ichi Nitta, Qingtian Wang, Hongjian Liu, Masaru Higa, Daisuke Ogawa, Akira Tanaka, Makoto Yoshizawa, Yasuyuki Kakubari, Hidekazu Miura, Fumihiro Sato, Hidetoshi Matsuki, Shinji Itoh, Akinori Kamoda, Ryo Sakata, Yumiko Wada, Miyuki Uematsu, Youngkwang Park, Takashi Tanaka, Mitsuo Umezu, Tetsuo Fujimoto, Noriyasu Masumoto, Hiroshi Sasada, Koichi Tabayashi, Eiji Okamoto, Dai Homma

    2006 SICE-ICASE International Joint Conference　1734-1737　2006

    DOI： 10.1109/SICE.2006.315627 　

  338. A System for Tissue Characterization and Quantification of Calcium Regions in Intravascular Ultrasound Peer-reviewed

    E. Santos Filho, Y. Saijo, T. Yambe, A. Tanaka, I. Iwamoto, S. Li, M. Yoshizawa

    2006 IEEE ULTRASONICS SYMPOSIUM, VOLS 1-5, PROCEEDINGS　1294-+　2006

    ISSN： 1051-0117

  339. Increased elasticity of capsule after immobilization in a rat knee experimental model assessed by scanning acoustic microscopy. International-journal Peer-reviewed

    Yoshihiro Hagiwara, Yoshifumi Saijo, Eiichi Chimoto, Hirotoshi Akita, Yasuyuki Sasano, Fujio Matsumoto, Shoichi Kokubun

    Upsala journal of medical sciences　111　(3)　303-13　2006

    ISSN： 0300-9734

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    OBJECTIVES: The mechanical property of immobilized joints is not well understood. The present study was designed to investigate the tissue elasticity of the anterior and posterior synovial membrane (SM) in a rat immobilized knee model using scanning acoustic microscopy (SAM). Moreover, the structural characteristics of the SM after immobilization were examined by transmission electron microscopy (TEM). METHODS: Thirty rats had their knee joints immobilized with a plate and metal screws. The rats were fixed at 1, 2, 4, 8 and 16 weeks after surgery and the knee joints were sectioned sagittally for SAM. Selected specimens were processed for TEM. A new concept SAM using a single pulsed wave instead of continuous waves was applied to measure the sound speed of the anterior and posterior SM, comparing it with the corresponding light microscopic images. RESULTS: The sound speed of the posterior SM increased significantly in the 8- and 16-week experimental group compared with that in the control group. The sound speed of the anterior SM showed no statistical difference between the experimental and the control groups at any period of immobilization. The posterior SM of the experimental group was different from that of the control group in the ultrastructural characteristics of extracellular matrices. CONCLUSIONS: Our data suggest that the increased elasticity and structural changes of the posterior SM are one of the main causes of limited extension after a long period of immobilization in flexion using SAM, which is a powerful tool for evaluating the elasticity of targeted tissues.

  340. Development of Cerebella Tissue of Rat Characterized by Acoustic Impedance Microscope Peer-reviewed

    A. Kimura, S. Terauchi, M. Nagao, S. Yoshida, K. Kobayashi, Y. Saijo, N. Hozumi

    2006 IEEE ULTRASONICS SYMPOSIUM, VOLS 1-5, PROCEEDINGS　1　1421-+　2006

    ISSN： 1051-0117

  341. Development of Ultrasonic-Measurement-Integrated Simulation System for Complex Blood flows

    Takayuki Yamagata, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the Fifth International Symposium of Advanced Fluid Information　61-62　2005/12

  342. Effect of Ultrasound Probe Placement in Ultrasonic-Measurement-Integrated Simulation of Blood Flows Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 12th International Conference on Biomedical Engineering (ICBME 2005)　CD-ROM　2005/12

    DOI： 10.1007/s10439-005-2495-2 　

  343. Parametric intravascular ultrasound imaging - Two-dimensional tissue velocity imaging and self-organizing map imaging. Peer-reviewed

    Saijo Y, Santos Filho E, Yambe T, Tanaka A, Iwamoto T, Yoshizawa M, Akino Y, Hanadate Y

    Proc 8th Sendai Symposium on Ultrasonic Tissue Characterization　1　1-4　2005/11/11

  344. Automatic luminal contour and calcification detection in intravascular ultrasound images. Peer-reviewed

    Santos Filho E, Saijo Y, Yoshizawa M, Tanaka A

    Proc 8th Sendai Symposium on Ultrasonic Tissue Characterization　1　5-8　2005/11/11

  345. Image processing for pulse driven biological microscope based on frequency spectrum. Peer-reviewed

    Kimura A, Terauchi S, Murakami Y, Hozumi N, Nagao M, Yoshida S, Kobayashi K, Saijo Y

    Proc 8th Sendai Symposium on Ultrasonic Tissue Characterization　1　30-31　2005/11/11

  346. Increased sound speed of synovial membrane after immobilization assessed by scanning acoustic microscopy. Peer-reviewed

    Hagiwara Y, Matsumoto F, Chimoto E, Kokubun S, Saijo Y, Sasano Y

    Proc 8th Sendai Symposium on Ultrasonic Tissue Characterization　32-35　2005/11/11

  347. Material properties of the rabbit supraspinatus tendon and its insertion - A measurement with the scanning acoustic microscopy. Peer-reviewed

    Sano H, Hattori K, Kokubun S, Saijo Y

    Proc 8th Sendai Symposium on Ultrasonic Tissue Characterization　1　36-38　2005/11/11

    DOI： 10.1142/S021895770400117X 　

  348. 埋込み型人工心筋装置による補助循環の際の血行動態に関する検討 Peer-reviewed

    王慶田, 山家智之, 白石泰之, 西條芳文, 梅津光生, 仁田新一

    人工臓器　34　(2)　S-122　2005/11

  349. 超微細径アクチュエータを用いたメカトロニクス心筋の開発 Peer-reviewed

    白石泰之, 山家智之, 関根一光, 金野敏, 西條芳文, 王慶田, 劉紅箭, 仁田新一, 佐藤文博, 小川大祐, 田中明, 吉澤誠, 岡本英治, 永利潤, 伊藤慎二, 植松美幸, 梅津光生, 田林晄一, 増本憲泰, 藤本哲男

    人工臓器　34　(2)　S-122　2005/11

  350. コイル状形状記憶合金による蠕動運動型人工食道の開発 Peer-reviewed

    関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 角張泰之, 三浦英和, 前田剛, 仁田新一

    人工臓器　34　(2)　S-116　2005/11

  351. 日本の人工臓器研究・開発に望まれるもの 冠動脈バイパスグラフトの術中評価(マルチポイントドプラ法)機器の開発 Peer-reviewed

    新田能郎, 西條芳文, 白石泰之, 山家智之, 若松立也, 田中元直, 田林晄一

    人工臓器　34　(2)　S-49　2005/11

    Publisher:

    DOI： 10.11392/jsao1972.34.2Supplement_s49 　

    ISSN： 0300-0818

  352. Effect of Feedback Domain in Ultrasonic-Measurement-Integrated Simulation on Reproduction of Blood Flow Field in an Aneurysmal Aorta

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 6th International Symposium on Future Medical Engineering based on Bio-nanotechnology (21st Century COE Program)　62-63　2005/11

  353. マルチポイントドプラによる冠動脈バイパスグラフト吻合部の術中評価法の開発 Peer-reviewed

    新田能郎, 白石泰之, 西條芳文, 山家智之, 若松立也, 田中元直, 田林晄一

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY　53　(Suppl.II)　336-336　2005/09

  354. Moment-based texture segmentation of luminal contour in intravascular ultrasound images Peer-reviewed

    Esmeraldo Dos Santos Filho, Makoto Yoshizawa, Akira Tanaka, Yoshifumi Saijo, Takahiro Iwamoto

    Journal of Medical Ultrasonics　32　(3)　91-99　2005/09

    DOI： 10.1007/s10396-005-0041-3 　

    ISSN： 1346-4523 1613-2254

  355. Influence of aging on cardiac function examined by echocardiography Peer-reviewed

    S Watanabe, N Suzuki, A Kudo, T Suzuki, S Abe, M Suzuki, S Komatsu, Y Saijo, N Murayama

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　207　(1)　13-19　2005/09

    DOI： 10.1620/tjem.207.13 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  356. 完全埋込型心室補助装置による循環補助 Peer-reviewed

    白石泰之, 山家智之, 関根一光, 西條芳文, 堀義生, 桑山貴志, 小川大祐, 田中明, 吉澤誠, 佐藤文博, 松木英敏, 羅雲, 高木敏行, 比嘉昌, 伊吹竜太, 圓山重直, 岡本英治, 青木秀宜, 永利潤, 伊藤慎二, 梅津光生, 佐々田比呂志, 王慶田, 段旭東, 劉紅箭, 仁田新一, 田林晄一

    生体医工学　43　(2)　328-328　2005/06

  357. Ultrasonic-Measurement-Integrated Simulation for Reproduction of Three-Dimensional Blood Flow Field in the Aorta with Aneurysm

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of ASME 2005 Summer Bioengineering Conference　CD-ROM　2005/06

  358. An innovative approach to evaluate a cardiac function based on surface measurement. Peer-reviewed

    Uematsu M, Shiraishi Y, Sekine K, Yambe T, Saijo Y, Park Y, Ando H, Matsumoto T, Takeda S, Iwasaki K, Umezu M

    Conf Proc IEEE Eng Med Biol Soc　7　7640-7643　2005/04

  359. Development of an Artificial Myocardium using a Covalent Shape-memory Alloy Fiber and its Cardiovascular Diagnostic Response. Peer-reviewed

    Shiraishi Y, Yambe T, Sekine K, Saijo Y, Wang Q, Liu H, Nitta S, Konno S, Masumoto N, Nagatoshi J, Itoh S, Park Y, Uematsu M, Umezu M, Ogawa D, Olegario P, Sato F, Yoshizawa M, Tanaka A, Tabayashi K, Sasada H, Fujimoto T, Homma D, Higa M, Hori Y

    Conf Proc IEEE Eng Med Biol Soc　1　(1)　406-408　2005/04

    DOI： 10.1109/IEMBS.2005.1616431 　

    ISSN： 0589-1019

  360. Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Yoshifumi Saijo, Tomoyuki Yambe

    Annals of Biomedical Engineering　33　(4)　415-428　2005/04

    DOI： 10.1007/s10439-005-2495-2 　

    ISSN： 0090-6964

  361. フーリエ変換型超音波顕微鏡の解析アルゴリズムの精度評価に関する研究 III

    青柳美広, LEE Cheol‐Kyou, 穂積直裕, 長尾雅行, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2005　(1)　143　2005/03/17

  362. 超音波顕微鏡による生体組織の音響パラメータ取得に関する検討

    LEE Cheol‐Kyou, 村上義信, 穂積直裕, 長尾雅行, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2005　(1)　142　2005/03/17

  363. Estimation of echo amplitude in pulsed ultrasonic microscopy

    TANAKA N, KOBAYASHI K, HOZUMI N, SAIJO Y, TANAKA M, OHTSUKI S

    日本音響学会研究発表会講演論文集　2005　(1)　721-722　2005/03/08

    ISSN： 1340-3168

  364. Artificial esophagus with peristaltic movement. Peer-reviewed

    Watanabe Makoto, Sekine Kazumitsu, Hori Yoshio, Shiraishi Yasuyuki, Maeda Takeshi, Honma Dai, Miyata Go, Saijo Yoshifumi, Yambe Tomoyuki

    ASAIO J　51　(2)　158-161　2005/03

    DOI： 10.1097/01.MAT.0000154644.44891.F1 　

  365. Improvement of the Precision of Ultrasonic Microscope for Biological Tissue Using the Automatic Extraction of the Reference Signals Peer-reviewed

    LEE Cheol-Kyou, MURAKAMI Yoshinobu, HOZUMI Naohiro, NAGAO Masayuki, KOBAYASHI Kazuto, SAIJO Yoshifumi, TANAKA Naohiko, OHTSUKI Shigeo

    IEEJ Transactions on Fundamentals and Materials　125-A　(2)　145-152　2005/02/01

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejfms.125.145 　

    ISSN： 0385-4205

    More details Close

    This paper deals with the precision of the ultrasonic microscopy for biological tissue characterization. The estimation error of sound speed influenced by the selection of reference points for obtaining the reference signal is described. In well known scanning type microscope, a focused ultrasonic signal is irradiated to the glass substrate on which a thin sliced tissue is attached. The reflected signal from the front surface of the tissue is compared with the signal from the glass substrate on which no tissue is attached. As the scanning plane and glass substrate are not completely in parallel, it is necessary to locate the glass surface at each measuring point. For this purpose, several reference points on which no tissue is attached are selected in the view field. The equation of the plane representing the glass surface is consequently obtained using the reflection at these reference points. However, the glass surface has an apparent surface roughness. This brings an estimation error of the equation of the plane. This error can be reduced by increasing the number of reference points. In order to extract a sufficient number of reference points automatically, an algorithm using the reflected wave was proposed to discriminate the points where the glass surface is exposed. Although the estimation error of sound speed with three reference points was as large as 31 m/s (as the double of standard deviation), it was reduced into as small as 16 m/s, when 1000 reference points had been automatically extracted.

  366. Effect of Density of Monitoring Points for Feedback in Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta with Aneurysm Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 3rd IASTED International Conference on Biomedical Engineering (BioMED2005)　118-123　2005/02

  367. Luminal contour detection in intravascular ultrasound images

    E. Santos Filho, M. Yoshizawa, A. Tanaka, Y. Saijo, T. Iwamoto

    Proceedings of the SICE Annual Conference　1076-1079　2005

  368. 1108 Blood Flow Simulation Integrated with Ultrasonic Measurement : 4^<th> Report: Improvement of Accuracy of Computational Hemodynamics

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    The proceedings of the JSME annual meeting　2005　89-90　2005

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecjo.2005.5.0_89 　

    More details Close

    Hemodynamics plays an important role in the development, progress and rupture of aneurysms, and therefore, is essential for advanced diagnosis. However, existing methodologies have yet to provide detailed and accurate information of blood flow field due to their individual limitations. As a solution to the problem, we have proposed Ultrasonic-Measurement-Integrated (UMI) simulation. In this method, feedback signals derived from the difference between measured Doppler velocity and the calculated one by numerical simulation are fed back to the numerical simulation. In this paper, we validate the efficacy of three-dimensional UMI simulation by the numerical analysis with various irradiation methods of ultrasonic beam. As the result, UMI simulation improves computational accuracy and enables us to obtain more accurate information of blood flow field including wall shear stress.

  369. 410 Study of Three-dimensional Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow in the Aorta

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    Proceedings of the JSME Bioengineering Conference and Seminar　2004　151-152　2005

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebs.2004.17.0_151 　

  370. Detection of luminal contour using fuzzy clustering and mathematical morphology in intravascular ultrasound images Peer-reviewed

    Esmeraldo Dos Santos Filho, Makoto Yoshizawa, Akira Tanaka, Yoshifumi Saijo, Takahiro Iwamoto

    2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7　3471-3474　2005

    ISSN： 1094-687X

  371. Coronary plaque classification through intravascular ultrasound radiofrequency data analysis using self-organizing map Peer-reviewed

    T Iwamoto, A Tanaka, Y Saijo, M Yoshizawa

    2005 IEEE Ultrasonics Symposium, Vols 1-4　2054-2057　2005

    ISSN： 1051-0117

  372. 508 Development of a totally implantable artificial myocardial assist system : Preliminary study of the hemodynamic effect in the mock circulatory system and in animal experiment

    AOKI Hidetaka, NITTA Shin-ichi, OKAMOTO Eiji, OGAWA Daisnke, YOSHIZAWA Makoto, TANAKA Akira, TANAKA Takashi, SASADA Hiroshi, TABAYASHI Koichi, HOMMA Dai, NAGATOSHI Jun, ITOH Shinji, SUDO Tomohiro, UMEZU Mitsuo, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, SAIJO Yoshifumi, YAMBE Tomoyuki

    Proceedings of the JSME Bioengineering Conference and Seminar　2004　(0)　191-192　2005

    Publisher: 一般社団法人 日本機械学会

    DOI： 10.1299/jsmebs.2004.17.0_191 　

  373. Detection of luminal contour using fuzzy clustering and mathematical morphology in intravascular ultrasound images. Peer-reviewed

    Dos Santos E, Yoshizawa M, Tanaka A, Saijo Y, Iwamoto T

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　4　3471-3474　2005

    DOI： 10.1109/IEMBS.2005.1617226 　

    ISSN： 1557-170X

  374. 生体組織診断のためのパルス励起型音速顕微鏡の開発 Peer-reviewed

    小林和人, 穂積直裕, 西條芳文, 大槻茂雄

    日本音響学会誌　44　(1.1)　e51-e55　2005

  375. Transdisciplinary Methodology Integrating Measurement and Simulation in Application of Complex Biomedical Flows

    Toshiyuki Hayase, Kenichi Funamoto, Takayuki Yamagata, Lei Liu, Atsushi Shirai, Makoto Ohta, Kosuke Inoue, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 5th International Symposium on Advanced Fluid information (AFI-2005)　36-39　2005

  376. Detection and correction of aliasing in ultrasonic measurement of blood flows with Ultrasonic-Measurement-Integrated simulation Peer-reviewed

    Kenichi Funamoto, Toshiyuki Hayase, Yoshifumi Saijo, Tomoyuki Yambe

    Technology and Health Care　13　(4)　331-344　2005

    ISSN： 0928-7329

  377. Sound speed scanning acoustic microscopy for biomedical applications. International-journal Peer-reviewed

    Yoshifumi Saijo, Hidehiko Sasaki, Naohiro Hozumi, Kazuto Kobayashi, Motonao Tanaka, Tomoyuki Yambe

    Technology and health care : official journal of the European Society for Engineering and Medicine　13　(4)　261-7　2005

    ISSN： 0928-7329

    More details Close

    Since 1985, we have been developing a scanning acoustic microscope (SAM) system for biomedical use and have been investigating the acoustic properties of various organs and disease states by using this SAM system. In biomedicine, SAM is useful for intraoperative pathological examination, study of low-frequency ultrasonic images, and assessment of biomechanics at a microscopic level. Recently, we have proposed a new concept -- acoustic microscopy -- using a single pulsed wave instead of continuous waves used in conventional SAM systems. In the present study, we compared two systems by measuring the same biological material. The sound speed image obtained by sound speed microscopy corresponded well to that obtained using a conventional SAM system. Lesions with hyaline degeneration showed a lower sound speed when compared with that of normal myocardium. Frequency domain analysis of amplitude and phase by both methods also showed similar characteristics. Although the data acquisition time of one frame was greater than that in conventional SAM, the total time required for calculation was significantly shorter. The SAM system can be applied to intraoperative pathological examination.

  378. Speed of sound microscopy for biomedical applications Peer-reviewed

    Y. Saijo, H. Sasaki, T. Yambe, M. Tanaka, N. Hozumi, K. Kobayashi, N. Okada

    Proceedings - IEEE Ultrasonics Symposium　1　419-422　2005

    DOI： 10.1109/ULTSYM.2005.1602883 　

    ISSN： 1051-0117

  379. Acoustic impedance micro-imaging for biological tissue using a focused acoustic pulse with a frequency range up to 100 MHz Peer-reviewed

    N Hozumi, A Kimura, S Terauchi, M Nagao, S Yoshida, K Kobayashi, Y Saijo

    2005 IEEE Ultrasonics Symposium, Vols 1-4　170-173　2005

    DOI： 10.1109/ULTSYM.2005.1602823 　

    ISSN： 1051-0117

  380. Speed of sound microscopy for biomedical applications Peer-reviewed

    Y Saijo, H Sasaki, T Yambe, M Tanaka

    2005 IEEE Ultrasonics Symposium, Vols 1-4　423-426　2005

    DOI： 10.1109/ULTSYM.2005.1602883 　

    ISSN： 1051-0117

  381. 形状記憶合金を用いた蠕動運動型人工食道の開発 Peer-reviewed

    関根一光, 山家智之, 西條芳文, 白石泰之

    加齢医学研究所雑誌　56　(1)　37-37　2004/11

  382. Basic ultrasonic characteristics of atherosclerosis measured by intravascular ultrasound and acoustic microscopy Peer-reviewed

    Y. Saijo, A. Tanaka, H. Sasaki, T. Iwamoto, E. Santos Filho, M. Yoshizawa, T. Yambe

    International Congress Series　1274　116-121　2004/10

    DOI： 10.1016/j.ics.2004.07.009 　

  383. Addition of rhythm to non-pulsatile circulation Peer-reviewed

    T Yambe, K Sekine, Y Shiraishi, M Watanabe, M Shibata, T Yamaguchi, QT Wang, XD Duan, HJ Liu, M Yoshizawa, A Tanaka, H Matsuki, F Sato, YI Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, E Sato, Y Saijo, S Nitta

    BIOMEDICINE & PHARMACOTHERAPY　58　S145-S149　2004/10

    DOI： 10.1016/S0753-3322(04)80024-6 　

    ISSN： 0753-3322

  384. Brachio-ankle pulse wave velocity and cardio-ankle vascular index (CAVI) Peer-reviewed

    T Yambe, M Yoshizawa, Y Saijo, T Yamaguchi, M Shibata, S Konno, S Nitta, T Kuwayama

    BIOMEDICINE & PHARMACOTHERAPY　58　S95-S98　2004/10

    DOI： 10.1016/S0753-3322(04)80015-5 　

    ISSN： 0753-3322

  385. A Japanese-Russian collaborative study on aging and atherosclerosis Peer-reviewed

    T Yambe, YA Kovalev, IA Milyagina, VA Milyagin, Y Shiraishi, M Yoshizawa, Y Saijo, T Yamaguchi, M Shibata, S Nitta

    BIOMEDICINE & PHARMACOTHERAPY　58　S91-S94　2004/10

    DOI： 10.1016/S0753-3322(04)80014-3 　

    ISSN： 0753-3322

  386. 超音波音速顕微鏡のための多成分エコー推定法

    田中直彦, 小林和人, 穂積直裕, 西条芳文, 田中元直, 大槻茂雄

    日本音響学会研究発表会講演論文集　2004　1359-1360　2004/09/21

    ISSN： 1340-3168

  387. 形状記憶合金「バイオメタル」を用いた蠕動運動型人工食道の開発研究 Peer-reviewed

    関根一光, 山家智之, 西條芳文, 白石泰之, 堀義生, 松木英敏, 佐藤文博, 本間大, 前田剛

    人工臓器　33　(2)　S221-S221　2004/09

  388. 完全埋込を目指した人工心室補助装置の血行力学的影響 慢性動物実験における心収縮補助効果の検討 Peer-reviewed

    白石泰之, 山家智之, 岡本英治, 関根一光, 小川大祐, ポール・オレガリオ, 吉澤誠, 青木秀宜, 永利潤, 伊藤慎二, 田中明, 佐藤文博, 西條芳文, 王慶田, 圓山重直, 早瀬敏幸, 松木英敏, 本間大, 梅津光生, 仁田新一

    人工臓器　33　(2)　S193-S193　2004/09

  389. Paclitaxel prevents loss of pulmonary endothelial barrier integrity during cold preservation Peer-reviewed

    S Suzuki, B Hao, T Sugawara, Y Matsuda, T Tabata, Y Hoshikawa, Y Saijo, T Kondo

    TRANSPLANTATION　78　(4)　524-529　2004/08

    DOI： 10.1097/01.TP.0000131951.72851.57 　

    ISSN： 0041-1337

  390. Application of Ultrasonic-Measurement-Integrated Simulation to Blood Flow

    Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Yoshifumi Saijo, Tomoyuki Yambe

    Proceedings of the 4th International Symposium on Future Medical Engineering based on Bio-nanotechnology　78-79　2004/06

  391. Development of the Pulse driven ultrasonic sound speed microscopy Peer-reviewed

    KOBAYASHI Kazuto, SAIJO Yoshifumi, HOZUMI Naohiro, TANAKA Naohiko, OHTSUKI Shigeo

    Journal of medical ultrasonics = 超音波医学　31　717-722　2004/04/15

    DOI： 10.1016/j.ultras.2003.11.005 　

    ISSN： 1346-1176

  392. Tissue velocity imaging of coronary artery by rotating-type intravascular ultrasound Peer-reviewed

    Y Saijo, S Tanaka, N Owada, Y Akino, S Nitta

    ULTRASONICS　42　(1-9)　753-757　2004/04

    DOI： 10.1016/j.ultras.2003.11.022 　

    ISSN： 0041-624X

  393. Time-frequency analysis for pulse driven ultrasonic microscopy for biological tissue characterization Peer-reviewed

    N Hozumi, R Yamashita, CK Lee, M Nagao, K Kobayashi, Y Saijo, M Tanaka, N Tanaka, S Ohtsuki

    ULTRASONICS　42　(1-9)　717-722　2004/04

    DOI： 10.1016/j.ultras.2003.11.005 　

    ISSN： 0041-624X

  394. Development of an ultra-portable echo device connected to USB port Peer-reviewed

    Y Saijo, S Nitta, K Kobayashi, H Arai, Y Nemoto

    ULTRASONICS　42　(1-9)　699-703　2004/04

    DOI： 10.1016/j.ultras.2003.11.009 　

    ISSN： 0041-624X

  395. Acoustic properties of aortic aneurysm obtained with scanning acoustic microscopy Peer-reviewed

    Y Saijo, T Miyakawa, H Sasaki, M Tanaka, S Nitta

    ULTRASONICS　42　(1-9)　695-698　2004/04

    DOI： 10.1016/j.ultras.2003.11.023 　

    ISSN： 0041-624X

  396. 医用フーリエ変換型超音波顕微鏡の精度評価(III)

    長江理都子, LEE C K, 村上義信, 穂積直裕, 長尾雅行, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2004　(1)　17　2004/03/17

  397. 参照点の自動抽出によるフーリエ変換型超音波顕微鏡の高精度化に関する検討

    LEE C K, 長江理都子, 村上義信, 穂積直裕, 長尾雅行, 田中直彦, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2004　(1)　160　2004/03/17

  398. Improvement of the Precision of Fourier Transform Ultrasonic Microscope for Biological Tissue Using the Automatic Extraction of the Reference Signals

    LEE C. K, HOZUMI N, NAGAO M, KOBAYASHI K, SAIJO Y, TANAKA N, OOTSUKI S, MURAKAMI Y

    日本音響学会研究発表会講演論文集　2004　(1)　1091-1092　2004/03/17

    ISSN： 1340-3168

  399. Spatial Resolution of Pulse-driven Ultrasonic Microscopy for Biological Tissue Characterization Inspected by 2D-FFT Image Processing

    KOBAYASHI K, NAGAE R, HOZUMI N, SAIJO Y, TANAKA N, OTSUKI S

    日本音響学会研究発表会講演論文集　2004　(1)　1093-1094　2004/03/17

    ISSN： 1340-3168

  400. A simple estimation of sound speed considering multiple echo components in ultrasonic microscopy

    TANAKA N, KOBAYASHI K, HOZUMI N, SAIJO Y, TANAKA M, OHTSUKI S

    日本音響学会研究発表会講演論文集　2004　(1)　1095-1096　2004/03/17

    ISSN： 1340-3168

  401. フーリエ変換型超音波顕微鏡の解析アルゴリズムの精度評価に関する検討

    青柳美広, LEE C‐K, 長江理都子, 穂積直裕, 長尾雅行, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2004　(1)　186　2004/03/17

  402. Material properties of the supraspinatus tendon at its insertion - A measurement with the scanning acoustic microscopy Peer-reviewed

    Hirotaka Sano, Yoshifumi Saijo, Shoichi Kokubun

    Journal of Musculoskeletal Research　8　(1)　29-34　2004/03

    DOI： 10.1142/S021895770400117X 　

    ISSN： 0218-9577

  403. Ultrasonic sound speed microscope for biological tissue characterization driven by nanosecond pulse Peer-reviewed

    N Hozumi, R Yamashita, CK Lee, M Nagano, K Kobayashi, Y Saijo, M Tanaka, N Tanaka, S Ohtsuki

    ACOUSTICAL IMAGING, VOL 27　27　495-501　2004

    ISSN： 0270-5117

  404. An adaptive fuzzy segmentation of intravascular ultrasound images Peer-reviewed

    E dos Santos, M Yoshizawa, A Tanaka, Y Saijo, T Iwamoto, T Yanibe, SI Nitta

    2004 2ND IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: MACRO TO NANO, VOLS 1 and 2　1311-1314　2004

  405. Morphological-fuzzy filter for enhancement of intravascular ultrasound images Peer-reviewed

    E dos Santos, M Yoshizawa, T Iwamoto, A Tanaka, Y Saijo

    SICE 2004 ANNUAL CONFERENCE, VOLS 1-3　1394-1397　2004

  406. Ultrasonic Sound Speed Microscope for Biological Tissue Characterization Driven by Nanosecond Pulse Peer-reviewed

    N. Hozumi, R. Yamashita, C-K. Lee, M. Nagao, K. Kobayashi, Y. Saijo, M. Tanaka, N. Tanaka, S. Ohtsuki

    Acoustical Science and Technology,　24　(6)　386-390　2003/11

    Publisher: Acoustical Society of Japan

    DOI： 10.1250/ast.24.386 　

    ISSN： 1346-3969

  407. Reproduction of Real Blood Flow in Aorta with Ultrasonic-Measurement-Integrated Simulation

    Kenichi Funamoto, Toshiyuki Hayase, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

    Proceedings of the 3rd International Symposium on Advanced Fluid Information (AFI-2003)　39-40　2003/11

  408. Artificial myocardium with an artificial baroreflex system using nano technology Peer-reviewed

    T Yambe, Y Shiraishi, M Yoshizawa, A Tanaka, K Abe, F Sato, H Matsuki, M Esashi, Y Haga, S Maruyama, T Takagi, Y Luo, E Okamoto, Y Kubo, M Osaka, S Nanka, Y Saijo, Y Mibiki, T Yamaguchi, M Shibata, S Nitta

    BIOMEDICINE & PHARMACOTHERAPY　57　122S-125S　2003/10

    DOI： 10.1016/j.biopha.2003.08.016 　

    ISSN： 0753-3322

    eISSN： 1950-6007

  409. A study on the estimation of reference spectrum in sound speed microscopy

    TANAKA N, KOBAYASHI K, HOZUMI N, SAIJO Y, TANAKA M, OHTSUKI S

    日本音響学会研究発表会講演論文集　2003　(2)　1161-1162　2003/09/17

    ISSN： 1340-3168

  410. 人工心筋駆動時の心拍ゆらぎ解析に基づき生体の自律神経への影響 Peer-reviewed

    段旭東, 白石泰之, 王慶田, 山家智之, 仁田新一, 田中明, 吉澤誠, 柴田宗一, 西條芳文, 小川大介

    人工臓器　32　(2)　S149-S149　2003/09

  411. 機械式人工心筋の開発 心補助効果と生体心臓との力学的相互作用の基礎検討 Peer-reviewed

    白石泰之, 岡本英治, 山家智之, 段旭東, 王慶田, 柴田宗一, 田中明, 小川大祐, 吉澤誠, 西條芳文, 仁田新一, 青木秀宜, 永利潤, 川合潤子, 末弘淳一, 吉田敬, 梅津光生, 井口篤志, 田林晄一, 圓山重直, 早瀬敏幸

    人工臓器　32　(2)　S149-S149　2003/09

  412. Influence of tissue preparation on the acoustic properties of tissue sections at high frequencies Peer-reviewed

    H Sasaki, Y Saijo, M Tanaka, SI Nitta

    ULTRASOUND IN MEDICINE AND BIOLOGY　29　(9)　1367-1372　2003/09

    DOI： 10.1016/S0301-5629(03)00991-8 　

    ISSN： 0301-5629

  413. Fast Fourier transform acoustic microscopy for biological tissues. Peer-reviewed

    Saijo Y, Hozumi N, Kobayashi K, Lee C, Nagao M, Ohtsuki S, Tanaka N, Sasaki H, Tanaka M

    Ultrasound Med Biol　29　(5S)　S20　2003/04

  414. Pocket-size echo connectable to a personal computer. Peer-reviewed

    Saijo Y, Kobayashi K, Arai H, Nemoto Y, Nitta S

    Ultrasound Med Biol　29　(5S)　S54　2003/04

  415. Intravascular tissue velocity imaging of coronary artery. Peer-reviewed

    Saijo Y, Tanaka A, Owada N, Akino Y, Nitta S

    Ultrasound Med Biol　29　(5S)　S173　2003/04

  416. 超音波音速顕微鏡のための試料存在判定法の検討

    田中直彦, 小林和人, 穂積直裕, 西条芳文, 田中元直, 大槻茂雄

    日本音響学会研究発表会講演論文集　2003　1345-1346　2003/03/18

    ISSN： 1340-3168

  417. 医療用フーリエ変換型超音波顕微鏡の線形性に関する研究

    LEE C, 山下理都子, 村本裕二, 穂積直裕, 長尾雅行, 小林和人, 西条芳文

    電気学会全国大会講演論文集　2003　(1)　263　2003/03/17

  418. Toward a neuro-fuzzy system for automatic segmentation and characterization of intravascular ultrasound images Peer-reviewed

    E dos Santos, M Yoshizawa, A Tanaka, Y Saijo, T Yambe, S Nitta

    SICE 2003 ANNUAL CONFERENCE, VOLS 1-3　1586-1589　2003

  419. Evidence-based Simulation of Blood Flow with Feedback of Ultrasonic Measurement

    Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

    The 1st International Symposium on Future Medical Engineering based on Bio-nanotechnology　40-42　2003/01

  420. Recent progress in artificial organ research at Tohoku University Peer-reviewed

    T Yambe, M Yoshizawa, A Tanaka, K Abe, S Kawano, H Matsuki, S Maruyama, S Amae, N Wada, T Kamiyama, T Takagi, R Luo, J Hayashi, YA Kovalev, DXD Sha, S Nanka, Y Saijo, Y Mibiki, M Shibata, S Nitta

    ARTIFICIAL ORGANS　27　(1)　2-7　2003/01

    DOI： 10.1046/j.1525-1594.2003.07181.x 　

    ISSN： 0160-564X

  421. Numerical Realization of Flow by Integrating Computation and Measurement in Medical Applications Invited

    Toshiyuki Hayase, Kenichi Funamoto, Keisuke Nisugi, Atsushi Shirai, Tomoyuki Yambe, Yoshifumi Saijo

    Proceedings of Mini-Symposium on Advanced Fluid Information: Fusion of EFD and CFD　77-85　2002/12

  422. Proximal (entry) tear of dissecting aortic aneurysm visualized by three-dimensional echocardiography Peer-reviewed

    Y Saijo, H Akimoto, Y Saiki, K Tabayashi, T Horinouchi, T Kobayashi, S Nitta

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　124　(6)　1245-1246　2002/12

    DOI： 10.1067/mtc.2002.125639 　

    ISSN： 0022-5223

  423. ナノ秒パルス励起による生体組織用超音波音速顕微鏡

    穂積直裕, 山下理都子, 長尾雅行, 小林和人, 西条芳文, 田中元直, 田中直彦, 大槻茂雄

    日本音響学会研究発表会講演論文集　2002　1007-1008　2002/09/26

    ISSN： 1340-3168

  424. 生体組織用超音波顕微鏡のための音速分布推定法の検討

    田中直彦, 小林和人, 穂積直裕, 西条芳文, 田中元直, 大槻茂雄

    日本音響学会研究発表会講演論文集　2002　1011-1012　2002/09/26

    ISSN： 1340-3168

  425. パルス励起超音波音速顕微鏡のビーム形状の検討

    小林和人, 根本由記子, 穂積直裕, 西条芳文, 田中元直, 田中直彦, 大槻茂雄

    日本音響学会研究発表会講演論文集　2002　1009-1010　2002/09/26

    ISSN： 1340-3168

  426. Acoustic inhomogeneity of carotid arterial plaques determined by GHz frequency range acoustic microscopy Peer-reviewed

    Y Saijo, CS Jorgensen, P Mondek, Sefranek, V, W Paaske

    ULTRASOUND IN MEDICINE AND BIOLOGY　28　(7)　933-937　2002/07

    DOI： 10.1016/S0301-5629(02)00527-6 　

    ISSN： 0301-5629

  427. Detecting Cardiac Allograft Rejection by Acoustic Microscopy Peer-reviewed

    Y. Saijo, A. Iguchi, K. Tabayashi, K. Kobayashi, H. Sasaki, A. Tanaka, N. Hozumi, S. Nitta

    Acoustical Imaging,　26　105-110　2002

  428. Application of scanning acoustic microscopy for assessing stress distribution in atherosclerotic plaque Peer-reviewed

    Y Saijo, T Ohashi, H Sasaki, M Sato, CS Jorgensen, SI Nitta

    ANNALS OF BIOMEDICAL ENGINEERING　29　(12)　1048-1053　2001/12

    DOI： 10.1114/1.1424912 　

    ISSN： 0090-6964

  429. Ultrasonic tissue characterization of collagen in lipid-rich plaques in apoE-deficient mice Peer-reviewed

    Y Saijo, CS Jorgensen, E Falk

    ATHEROSCLEROSIS　158　(2)　289-295　2001/10

    DOI： 10.1016/S0021-9150(01)00435-X 　

    ISSN： 0021-9150

  430. Evaluation of the biomechanics of atherosclerosis by acoustic microscopy Peer-reviewed

    Yoshifumi Saijo, Shin-ichi Nitta, Claus S. Jørgensen, Erling Falk

    Proceedings of SPIE - The International Society for Optical Engineering　4335　(1)　228-235　2001/07/24

    DOI： 10.1117/12.434177 　

    ISSN： 0277-786X

  431. A single-beat estimation method for emax directly based on linearity of ventricular elastance

    Makoto Yoshizawa, Megumi Yokogawa, Akira Tanaka, Ken-Ichi Abe, Hiroshi Takeda, Yoshifumi Saijo, Tomoyuki Yambe, Shin-Ichi Nitta

    Annual Reports of the Research Reactor Institute, Kyoto University　1　155　2001

    ISSN： 0454-9244

  432. A single-beat estimation method for Emax directly based on linearity of ventricular elastance Peer-reviewed

    M Yoshizawa, M Yokogawa, A Tanaka, K Abe, H Takeda, Y Saijo, T Yambe, S Nitta

    PROCEEDINGS OF THE 23RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4　23　155-155　2001

    ISSN： 1094-687X

  433. Microscopy Peer-reviewed

    Yoshifumi Saijo, Noriyoshi Chubachi

    Ultrasound in Medicine and Biology　26　(1)　S30-S32　2000/05

    Publisher: Elsevier Science Ltd

    DOI： 10.1016/S0301-5629(00)00157-5 　

    ISSN： 0301-5629

  434. Collagen characterization by polarized and acoustic microscopy. Peer-reviewed

    Saijo Y, Sasaki H, Nitta S, Tanaka M, Jorgensen CS, Falk E

    Ultrasound Med Biol　26　(Suppl 2)　A57　2000/04

  435. Prediction of plaque rupture by finite element analysis of IVUS imaging. Peer-reviewed

    Saijo Y, Ohashi T, Sasaki H, Kanno T, Miyakawa T, Nitta S, Tanaka M

    Ultrasound Med Biol　26　(Suppl 2)　A88　2000/04

  436. Visualization of human umbilical vein endothelial cells by acoustic microscopy Peer-reviewed

    Y Saijo, H Sasaki, M Sato, S Nitta, M Tanaka

    ULTRASONICS　38　(1-8)　396-399　2000/03

    DOI： 10.1016/S0041-624X(99)00200-0 　

    ISSN： 0041-624X

  437. Spatial pressure distribution in left ventricle by Doppler-Pressure-Method

    S. Sugawara, M. Tanaka, K. Nitta, Y. Saijo, S. Nitta, S. Ohtsuki

    Ultrasound in Medicine and Biology　26　(2)　A42　2000

    Publisher: Elsevier Science Ltd

    ISSN： 0301-5629

  438. Influence of fat component on the high-frequency acoustic properties

    H. Sasaki, Y. Saijo, M. Tanaka, S. Nitta

    Ultrasound in Medicine and Biology　26　(2)　A64　2000

    Publisher: Elsevier Science Ltd

    ISSN： 0301-5629

  439. Evaluation of the inner-surface morphology of an artificial heart by acoustic microscopy Peer-reviewed

    Y Saijo, H Okawai, H Sasaki, T Yambe, S Nitta, M Tanaka, K Kobayashi, Y Honda

    ARTIFICIAL ORGANS　24　(1)　64-69　2000/01

    DOI： 10.1046/j.1525-1594.2000.06349.x 　

    ISSN： 0160-564X

  440. Collagen characterization of fibrous caps in Apo-E deficient mice by acoustic microscopy. Peer-reviewed

    Saijo Y, Jorgensen C, Falk E, Nitta S

    Circulation　100　(18)　I251　1999/04

  441. Successful closure of coronary-bronchial artery fistula with vein graft-coated stent Peer-reviewed

    Y Saijo, K Izutsu, T Sonobe, Y Okuyama, T Yambe, S Nitta

    CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS　46　(2)　214-217　1999/02

    DOI： 10.1002/(SICI)1522-726X(199902)46:2<214::AID-CCD22>3.0.CO;2-J 　

    ISSN： 1522-1946

  442. Bilateral pneumothoraces with multiple bullae in a patient with asymptomatic bronchiolitis obliterans 10 years after bone marrow transplantation Peer-reviewed

    T. Suzuki, Y. Saijo, M. Ebina, M. Yaekashiwa, M. Minegishi, S. Tsuchiya, T. Konno, S. Ono, Y. Matsumura, S. Fujimura, T. Nukiwa

    Bone Marrow Transplantation　23　(8)　829-831　1999

    Publisher: Nature Publishing Group

    DOI： 10.1038/sj.bmt.1701660 　

    ISSN： 0268-3369

  443. Acoustic properties of atherosclerosis of human aorta obtained with high-frequency ultrasound Peer-reviewed

    Y Saijo, H Sasaki, H Okawai, S Nitta, M Tanaka

    ULTRASOUND IN MEDICINE AND BIOLOGY　24　(7)　1061-1064　1998/09

    DOI： 10.1016/S0301-5629(98)00054-4 　

    ISSN： 0301-5629

  444. Brain imaging by acoustic microscopy. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Sato Kozo, Okawai Hiroaki, Nitta Shin-ichi, Tanaka Motonao

    Eur J Ultrasound　7　(suppl)　s55　1998/04

  445. Non-destructive Detection of Material Fatigue in Artificial Heart by Scanning Acoustic Microscopy

    SAIJO Yoshifumi, OKAWAI Hiroaki, SASAKI Hidehiko, YAMBE Tomoyuki, NITTA Shin-ichi, TANAKA Motonao, KOBAYASHI Kazuto, HONDA Yosuke

    Transactions of Visualization Society of Japan　18　(70)　187-191_1　1998

    Publisher: The Visualization Society of Japan

    DOI： 10.3154/jvs.18.70_187 　

    ISSN： 0916-4731

  446. Morphological and acoustical changes of endothelium by fluid shear stress Peer-reviewed

    Y Saijo, H Sasaki, N Kataoka, M Sato, S Nitta, M Tanaka

    1998 IEEE ULTRASONICS SYMPOSIUM - PROCEEDINGS, VOLS 1 AND 2　2　1333-1336　1998

    ISSN： 1051-0117

  447. Latest microscopic technique. From principle to application. Form evaluation of cultured cells by ultrasonic microscopes.

    SAIJO Y, OKAWAI H, NITTA S, TANAKA M

    Transactions of Japanese Society for Medical and Biological Engineering　11　(10)　37-41　1997/10/10

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe1987.11.10_37 　

    ISSN： 0913-7556

  448. Acoustic properties of dialysed kidney by scanning acoustic microscopy Peer-reviewed

    H Sasaki, Y Saijo, M Tanaka, S Nitta, Y Terasawa, T Yambe, Y Taguma

    NEPHROLOGY DIALYSIS TRANSPLANTATION　12　(10)　2151-2154　1997/10

    DOI： 10.1093/ndt/12.10.2151 　

    ISSN： 0931-0509

  449. Characterization of renal angiomyolipoma by scanning acoustic microscopy Peer-reviewed

    H Sasaki, Y Saijo, M Tanaka, S Nitta, T Yambe, Y Terasawa

    JOURNAL OF PATHOLOGY　181　(4)　455-461　1997/04

    DOI： 10.1002/(SICI)1096-9896(199704)181:4<455::AID-PATH788>3.0.CO;2-J 　

    ISSN： 0022-3417

  450. Visualization of cultured cells by scanning acoustic microscope system. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Nitta Shin-ichi, Tanaka Motonao

    Proc 1997 World Congress on Ultrasonics　1　502-503　1997/04

  451. Effect of argatroban for the treatment of intimal dissection following percutaneous transluminal coronary angioplasty. Peer-reviewed

    Saijo Y, Kikuchi Y, Izutsu K, Yambe T, Nitta S

    1st International Congress on Coronary Artery Disease　1　44　1997/04

  452. Anatomical and physiological approach to the chromatic mechanisms

    SAIJO Yoshifumi

    Transactions of Visualization Society of Japan　17　(64)　7-11　1997/01/05

    Publisher: The Visualization Society of Japan

    DOI： 10.3154/jvs.17.7 　

    ISSN： 0916-4731

  453. Relationship between micro- and macro-acoustic properties of myocardium Peer-reviewed

    Y Saijo, H Sasaki, H Okawai, S Nitta

    PROCEEDINGS OF THE 18TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 18, PTS 1-5　18　863-864　1997

  454. Ultrasonic tissue characterization of infarcted myocardium by scanning acoustic microscopy Peer-reviewed

    Y Saijo, M Tanaka, H Okawai, H Sasaki, SI Nitta, F Dunn

    ULTRASOUND IN MEDICINE AND BIOLOGY　23　(1)　77-85　1997

    DOI： 10.1016/S0301-5629(96)00174-3 　

    ISSN： 0301-5629

  455. Ultrasonic properties of myocardium in low MHz frequencies assessed by acoustic microscopy. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Nitta Shin-ichi

    Eur J Ultrasound　4　(suppl 1)　s64　1996/04

  456. Visualization of inner surface morphology of artificial heart by scanning acoustic microscopy. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Yambe Tomoyuki, Nitta Shin-ichi

    Proc 2nd International Congress on Robotics, Vision, Parallel Processing for Industrial Automation　2　51-54　1996/04

  457. Evaluation of the material fatigue of artificial heart by a frequency domain analysis of pulsed ultrasound. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Yambe Tomoyuki, Nitta Shin-ichi

    Proc 2nd International Congress on Robotics, Vision, Parallel Processing for Industrial Automation　2　108-111　1996/04

  458. Influence of tissue preparation on the high-frequency acoustic properties of normal kidney tissue Peer-reviewed

    H Sasaki, Y Saijo, M Tanaka, H Okawai, Y Terasawa, T Yambe, S Nitta

    ULTRASOUND IN MEDICINE AND BIOLOGY　22　(9)　1261-1265　1996

    DOI： 10.1016/S0301-5629(96)00150-0 　

    ISSN： 0301-5629

  459. Ultrasonic tissue characterization of renal cell carcinoma tissue Peer-reviewed

    Hidehiko Sasaki, Motonao Tanaka, Yoshifumi Saijo, Hiroaki Okawai, Yoshio Terasawa, Shin-Ichi Nitta, Kiichi Suzuki

    Nephron　74　(1)　125-130　1996

    DOI： 10.1159/000189291 　

    ISSN： 2235-3186 1660-8151

  460. Ultrasonic tissue characterization of three-layered structure of coronary artery by scanning acoustic microscopy. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Naganuma Toru, Tanaka Motonao

    J Heart Failure　2　558　1995/04

  461. Visualization of intracardiac local flow states by two-dimensional stream line distributions. Peer-reviewed

    Saijo Yoshifumi, Tanaka Motonao, Takahashi Kazuhiko, Chiba Shigeki, Mitsuoka Mikio, Naganuma Toru

    J Heart Failure　2　622　1995/04

  462. Ultrasonic properties of the tissue elements of coronary artery by scanning acoustic microscopy. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Naganuma Toru, Tanaka Motonao

    Heart Vessels　suppl 11　44　1995/04

  463. Estimation of local blood flow volume by stream line distributions. Peer-reviewed

    Saijo Yoshifumi, Tanaka Motonao, Takahashi Kazuhiko, Chiba Shigeki, Mitsuoka Mikio, Naganuma Toru

    Heart Vessels　suppl 11　81　1995/04

  464. Frequency dependent characteristics of ultrasonic attenuation in liver tissue. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Tanaka Motonao

    Proc 1st World Congress on Ultrasonics　1　1059-1062　1995/04

  465. Ultrasonic tissue characterization of diseased myocardium by scanning acoustic microscopy Peer-reviewed

    Y. Saijo, H. Sasaki, T. Naganuma, M. Tanaka

    Journal of Cardiology　25　(3)　127-132　1995

    ISSN： 0914-5087

  466. 「脈診」における決定論的カオス Peer-reviewed

    山家智之, 仁田新一, 高橋和彦, 密岡幹夫, 千葉茂樹, 薗部太郎, 西條芳文, 永沼 滋, 柿沼義人, 井筒憲司, 永沼 徹, 小林信一, 佐々木英彦, 芳賀洋一, 南家俊介, 大沢 上, 田中元信, 吉沢 誠, 小出 訓, 阿部健一, 竹田 宏, 高島 充, 佐藤由樹, 渥美和彦

    自律神経　31　85-91　1994/04

  467. Ultrasonic tissue characterization of coronary artery by scanning acoustic microscope. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Naganuma Toru, Tanaka Motonao

    Ultrasound Med Biol　20　(suppl 1)　72　1994/04

  468. Assessment of three-layered appearance of coronary artery in intravascular ultrasound by scanning acoustic microscope. Peer-reviewed

    Saijo Yoshifumi, Sasaki Hidehiko, Naganuma Toru, Tanaka Motonao

    Eur Heart J　15　(suppl)　258　1994/04

  469. VISUALIZATION OF ACOUSTIC PROPERTIES OF BIOLOGICAL TISSUES BY SCANNING ACOUSTIC MICROSCOPY

    SAIJO Yoshifumi, TANAKA Motonao

    Transactions of Visualization Society of Japan　14　(2)　189-192　1994

    Publisher: The Visualization Society of Japan

    DOI： 10.3154/jvs.14.Supplement2_189 　

    ISSN： 0916-4731

    More details Close

    It is very important to determine the acoustic properties of biological tissues for two major aspects; one is that the acoustic parameters give the physical properties that could not be detected by optical microscopy, and the other is that the data provides information for understanding echographic imaging.In the present study, a scanning acoustic microscope (SAM) system was equipped to measure the acoustic properties of biological tissue at the microscopic level.

  470. Assessment of elasticity of acute myocardial infarction tissue by a scanning acoustic microscope system. Peer-reviewed

    Saijo Yoshifumi, Okawai Hiroaki, Sasaki Hidehiko, Naganuma Toru, Tanaka Motonao

    Eur J Ultrasound　1　s64　1993/04

  471. Estimation of intracardiac local flow state by two-dimensional display of the stream lines. Peer-reviewed

    Saijo Yoshifumi, Tanaka Motonao, Yamamoto Atsuko, Endo Norio, Takahashi Kazuhiko, Satoh Noriko, Chiba Shigeki

    J Cardiol　23　(suppl 37)　125-131　1993/04

  472. Echo-guided transaortic left ventricular myotomy for idiopathic hypertrophic subaortic stenosis. Peer-reviewed

    Nitta S, Yambe T, Nitta K, Katahira Y, Saijo Y, Sonobe T, Naganuma S, Kakinuma Y, Tanaka M, Miura M

    Sci Rep Res Inst Tohoku Univ [Med]　38　(2-4)　65-67　1991/12

  473. [A case of giant cell myocarditis associated with a progressive disturbance in the conduction system] Peer-reviewed

    Saijo Y, Nitta S, Katahira Y, Takahashi K, Yambe T, Endoh N, Sonobe T, Tanaka M, Meguro T, Nitta K

    Kokyu To Junkan　39　(4)　373-376　1991/04

    DOI： 10.11477/mf.1404900261 　

  474. THE ULTRASONIC PROPERTIES OF GASTRIC-CANCER TISSUES OBTAINED WITH A SCANNING ACOUSTIC MICROSCOPE SYSTEM Peer-reviewed

    Y SAIJO, M TANAKA, H OKAWAI, F DUNN

    ULTRASOUND IN MEDICINE AND BIOLOGY　17　(7)　709-714　1991

    ISSN： 0301-5629

  475. Regional myocardial behaviour cardiac surface under arrhythmic conditions

    Uematsu M, Shiraishi Y, Sekine K, Yambe T, Saijo Y, Ando H, Park Y, Takeda S, Iwasaki K, Umezu M

    Proceedings of 12th International Conference on Biomedical Engineering　12　1A5-05

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  2. High frequency ultrasound / photoacoustic imaging at Tohoku University

    西條芳文, 新楯諒, 鈴木陸, 石井琢郎, 荒川元孝, 梅村晋一郎, 吉澤晋, 長岡亮, 小林和人, 根本隆治

    超音波医学 Supplement　49　2022

    ISSN： 1881-9311

  3. Evaluation of Coherence Factor Weighting Methods for Enhancing the Image Quality of Photoacoustic Microscopy

    鈴木陸, 新楯諒, 石井琢郎, 石井琢郎, 西條芳文

    超音波医学 Supplement　49　2022

    ISSN： 1881-9311

  4. MEMSミラーを用いた高速撮像光音響顕微鏡システムの開発 ミラー走査由来の画像歪みに対する補正手法の検討と併せて

    新楯 諒, Kim Chulhong, 西條 芳文

    電子情報通信学会技術研究報告(超音波)　121　(182)　28-33　2021/09

    Publisher: (一社)電子情報通信学会

    ISSN： 0913-5685

    eISSN： 2432-6380

  5. Comparison of Ultrasound and Photoacoustic Imaging of Cell

    SAIJO Yoshifumi, SHINTATE Ryo, KAWAGUCHI Kota, ARAKAWA Mototaka, ISHII Takuro, KANZAKI Makoto, KOBAYASHI Kazuto

    日本生体医工学会大会プログラム・抄録集(Web)　60th　2021

  6. Effect of Coherence Factor Weighting for Improving the Image Quality of an Annular Array Photoacoustic Microscope

    SUZUKI Riku, SHINTATE Ryo, ISHII Takuro, SAIJO Yoshifumi

    超音波エレクトロニクスの基礎と応用に関するシンポジウム(CD-ROM)　42nd　2021

    ISSN： 2189-9606

  7. 3D Ultrasound Imaging by Synthetic Transmit Aperture Beamforming Obtained with a Spherically Curved Array Transducer

    HAYASHI Eiki, KANNO Naoya, SHINTATE Ryo, ISHII Takuro, NAGAOKA Ryo, SAIJO Yoshifumi

    超音波エレクトロニクスの基礎と応用に関するシンポジウム(CD-ROM)　42nd　2021

    ISSN： 2189-9606

  8. Cell Dynamics Imaging with an Optical / Photoacoustic Hybrid Microscopy

    新楯諒, 長岡亮, 石井琢郎, 西條芳文

    超音波医学 Supplement　48　2021

    ISSN： 1881-9311

  9. Optical/Photoacoustic Hybrid Microscopy with Deconvolution Processing for Visualizing Morphology and Composition of Cells

    SHINTATE Ryo, NAGAOKA Ryo, ISHII Takuro, SAIJO Yoshifumi

    超音波エレクトロニクスの基礎と応用に関するシンポジウム(CD-ROM)　41st　2020

    ISSN： 2189-9606

  10. Three-dimensional photoacoustic imaging using a hemispherical array transducer and four way oblique laser irradiation

    森野太介, 新楯諒, 林瑛己, 長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  11. Development of high-resolution photoacoustic microscopy that enables clear imaging of cells

    新楯諒, 長岡亮, 小林和人, 西條芳文

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  12. Investigation of subcutaneous micro-vessels using photoacoustic microscopy

    平塚竜基, 高橋爽, 菅野尚哉, 新楯諒, 梅村晋一郎, 西條芳文

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  13. Statistical examination of sound velocity and acoustic impedance measured by an acoustic microscope

    小林和人, 小林和人, 栗原唯生, 栗原唯生, 西條芳文, 穂積直裕

    超音波医学 Supplement　47　2020

    ISSN： 1881-9311

  14. 高周波数帯域の光音響信号による細胞レベルのイメージング

    西條芳文, 新楯諒, 高橋爽, 平塚竜基, 石井琢郎, 吉澤晋, 梅村晋一郎, 長岡亮, 岩崎秀明, 伊田泰一郎

    乳腺甲状腺超音波医学　9　(4)　2020

    ISSN： 2187-2880

  15. Imaging with Acoustic Resolution Photoacoustic Microscope using Annular Array Transducer

    平塚竜基, 高橋爽, 佐藤滉太, 新楯諒, 梅村晋一郎, 石井琢郎, 石井琢郎, 西條芳文

    電子情報通信学会技術研究報告(Web)　120　(174(US2020 27-42))　2020

    ISSN： 2432-6380

  16. 光超音波トモグラフィにおける光超音波信号の初期位相の補正による深さ分解能の改善に関する研究 : 高空間分解能化を目指して (特集 超音波を使用した医療のあり方を探る(1))

    長岡 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文

    超音波techno　31　(3)　70-74　2019/05

    Publisher: 日本工業出版

    ISSN： 0916-2410

  17. 大動脈弁狭窄症の心内血流動態の解析

    皆川 忠徳, 武田 美貴, 平沼 和希子, 松岡 孝幸, 清水 拓也, 三浦 誠, 川本 俊輔, 西條 芳文

    日本心臓血管外科学会学術総会抄録集　49回　[OP28-1]　2019/02

    Publisher: (NPO)日本心臓血管外科学会

  18. Visualization of cell structure by optical resolution photoacoustic microscopy with sub-micron lateral resolution

    SHINTATE Ryo, NAGAOKA Ryo, KOBAYASHI Kazuto, SAIJO Yoshifumi

    超音波エレクトロニクスの基礎と応用に関するシンポジウム(CD-ROM)　40th　2019

    ISSN： 2189-9606

  19. 高周波数アニュラアレイセンサによる被写界深度の拡大

    藤井佳祐, 佐藤泰, 菅野尚哉, 新楯諒, 小林和人, 吉澤晋, 梅村晋一郎, 西條芳文

    電子情報通信学会技術研究報告　119　(211(US2019 46-56))　2019

    ISSN： 0913-5685

  20. Comparative study of one-way vertical illumination and four-way oblique illumination in three-dimensional photoacoustic imaging using a hemispherical array transducer

    森野太介, 新楯諒, 長岡亮, 吉澤晋, 梅村晋一郎, 西條芳文

    電子情報通信学会技術研究報告　119　(211(US2019 46-56))　2019

    ISSN： 0913-5685

  21. Visualization of skin morphology and microcirculation with high frequency ultrasound and dual-wavelength photoacoustic microscope

    Yoshifumi Saijo, Taiichiro Ida, Hideaki Iwazaki, Jun Miyajima, Huabin Tang, Ryo Shintate, Kanta Sato, Tatsuki Hiratsuka, Shin Yoshizawa, Shinichiro Umemura

    Progress in Biomedical Optics and Imaging - Proceedings of SPIE　10878　2019/01/01

    DOI： 10.1117/12.2508599 　

    ISSN： 1605-7422

  22. 2P5-19 Multidirectional reception of photoacoustic signal for higher resolution imaging

    Sato Kanta, Shintate Ryo, Fujiwara Mitsuhiro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　39　n/a　2018/10/29

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.39.0_2p5-19 　

    ISSN： 1348-8236

    eISSN： 2433-1910

  23. 正常肩コンマサイン部を組織学的に研究する試み

    新井 隆三, 萩原 嘉廣, 西條 芳文, 馬谷 直樹, 松田 秀一

    日本肩関節学会抄録集　45回　259-259　2018/09

    Publisher: (一社)日本肩関節学会

  24. 超音波計測技術 超音波顕微鏡による生体試料の音響特性の解析方法の検討=ロバストな解析方法を目指して=

    荒川元孝, 森翔平, 金井浩, 堀江みき, 西條芳文, 長岡亮, 小林和人, 小林和人

    超音波Techno　30　(6)　2018

    ISSN： 0916-2410

  25. High resolution photoacoustic imaging by multidirectional signal acquisition

    佐藤幹太, 新楯諒, 藤原光浩, 西條芳文

    電子情報通信学会技術研究報告　118　(229(US2018 49-62))　2018

    ISSN： 0913-5685

  26. Design of transmission-mode photoacoustic microscopy using high frequency transducer

    新楯諒, 長岡亮, 小林和人, 西條芳文

    電子情報通信学会技術研究報告　118　(229(US2018 49-62))　2018

    ISSN： 0913-5685

  27. ガルバノスキャンを用いた光音響イメージング用高速走査機構の開発

    石川広大, 長岡亮, 板谷信行, 萩原嘉廣, 西條芳文

    日本超音波医学会光超音波画像研究会プログラム・抄録集　2017　(4th)　7‐11　2018

  28. Improvement of High Frequency Ultrasound Images by Point Spread Function Obtained with Optical Coherence Tomography

    117　(227)　5-10　2017/10/05

    Publisher: 電子情報通信学会

    ISSN： 0913-5685

  29. 心移植患者における心エコーによる左室拡張末期圧推定指標の有用性

    藤原 淳子, 青木 竜男, 船水 康陽, 三木 俊, 西條 芳文, 杉村 宏一郎, 坂田 泰彦, 秋山 正年, 齋木 佳克, 下川 宏明

    超音波医学　43　(Suppl.)　S602-S602　2016/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  30. 頸動脈壁の粘弾性計測に関する検討

    R. Nagaoka, M. Arakawa, S. Yoshizawa, S. Umemura, Y. Saijo, K. Kobayashi

    超音波テクノ　28　(3)　10-14　2016

    Publisher: 日本工業出版

  31. 1P5-11 Monitoring of High-Intensity Focused Ultrasound Treatment Using Shear Wave Elastography Induced by 2D Array Therapeutic Transducer

    Iwasaki Ryosuke, Takagi Ryo, Nagaoka Ryo, Jimbo Hayato, Yoshizawa Shin, Saijo Yoshifumi, Umemura Shin-ichiro

    Proceedings of Symposium on Ultrasonic Electronics　36　"1P5-11-1"-"1P5-11-2"　2015/11/05

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  32. 癒着、瘢痕、拘縮の制御 関節拘縮の機序

    萩原 嘉廣, 矢部 裕, 金澤 憲治, 小出 将志, 関口 拓矢, 西條 芳文, 井樋 栄二

    日本整形外科学会雑誌　89　(8)　S1807-S1807　2015/09

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  33. 2P5-10 Detection of Thermally-Induced Lesion Using Shear Wave Imaging in Cavitation-Enhanced High-Intensity Focused Ultrasound Therapy(Poster Session)

    Iwasaki Ryosuke, Nagaoka Ryo, Takagi Ryo, Goto Kota, Yoshizawa Shin, Saijo Yoshifumi, Umemura Shin-ichiro

    Proceedings of Symposium on Ultrasonic Electronics　35　323-324　2014/12/03

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  34. 3P5-19 A Basic Study of Intrinsic Elastography Based on Propagation Velocity Distribution Induced by Artery Pulsation(Poster Session)

    Nagaoka Ryo, Iwasaki Ryosuke, Arakawa Mototaka, Kobayashi Kazuto, Yoshizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　35　545-546　2014/12/03

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  35. A Basic Study of Visualization of Propagation Velocity Distribution Induced by Arterial Pulsation

    Nagaoka Ryo, Arakawa Mototaka, Kobayashi Kazuto, Yoshizawa Shin, Umemura Shin-ichiro, Saijo Yoshifumi

    The Computational Mechanics Conference　2014　(27)　362-363　2014/11/22

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-026X

  36. Estimation of blood flow vectors based on ultrasonic Doppler method

    The Computational Mechanics Conference　2014　(27)　364-365　2014/11/22

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-026X

  37. ラット膝関節拘縮モデルにおけるヒアルロン酸の関節拘縮予防効果の検討

    金澤 憲治, 萩原 嘉廣, 土谷 昌広, 矢部 裕, 園淵 和明, 小出 将志, 安藤 晃, 関口 拓矢, 西條 芳文, 井樋 栄二

    日本整形外科学会雑誌　88　(8)　S1655-S1655　2014/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  38. 光音響イメージングによるミクロレベルの組織血流評価

    西條芳文, 佐藤みか, 山崎玲奈, 長岡亮, 鷲尾勝由, 松浦祐司

    超音波医学　41　(Suppl.)　S203-S203　2014/04/15

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  39. ソノサイトメトリーの基盤技術の検討

    小松 洋介, 長岡 亮, 船本 健一, 早瀬 敏幸, 政氏 伸夫, 金井 浩, 西條 芳文

    超音波医学　41　(Suppl.)　S481-S481　2014/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

  40. 2B41 Recent development of ultrasound microscope for biomedical applications

    SAIJO Yoshifumi

    2014　(26)　325-326　2014/01/10

    Publisher: The Japan Society of Mechanical Engineers

  41. 2B42 Measurement of skin elasticity by high frequency ultrasound

    NAGAOKA Ryo, KOBAYASHI Kazuto, SAIJO Yoshifumi

    2014　(26)　327-328　2014/01/10

    Publisher: The Japan Society of Mechanical Engineers

  42. 2P5-2 High Frequency Ultrasound Measurement of Micro Displacement in Human Skin Induced by Arterial Pulsation(Poster Session)

    Nagaoka Ryo, Kobayashi Kazuto, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　34　303-304　2013/11/20

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  43. 3J5-3 Characterization of Single Cell Properties Using High-frequency Ultrasound(Biomedical Ultrasound 1)

    Yoshida Koki, Abuhabsah Rami, Pawlicki Alexander D., Shikama Joe, Nagaoka Ryo, Saijo Yoshifumi, O'Brien William D. Jr

    Proceedings of Symposium on Ultrasonic Electronics　34　395-396　2013/11/20

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  44. 2P5-4 Three-dimensional Photoacoustic Imaging of Chicken Embryo Vasculature(Poster Session)

    Sato Mika, Yamazaki Rena, Watanabe Yuji, Nakamura Harukazu, Matsuura Yuji, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　34　307-308　2013/11/20

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  45. 3P5-19 Two-dimensional Blood Flow Vector obtained by Bidirectional Doppler Ultrasound with Parallel Beamforming(Poster Session)

    Masuno Genta, Nagaoka Ryo, Sasaki Shoya, Yoshizawa Shin, Umemura Shinichiro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　34　527-528　2013/11/20

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  46. Acoustic characteristic analysis of fatty and fibrosis rat liver by using 80 MHz and 250 MHz bioacoustic microscopy

    Inoue Kenta, Mamou Jonathan, Kobayashi Kazuto, Saijo Yoshifumi, Yamaguchi Tadashi

    IEICE technical report. Ultrasonics　113　(13)　21-26　2013/04/23

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    Ultrasonic quantitative diagnosis are beginning to use in clinical site. It is first necessary to understand the relationship between the characteristics of echo signal and tissue property. Towards this aim, speed-of-sound (SOS) and attenuation from three types of rat livers (normal, fatty and fibrosis) were measured with a scanning bioacoustic microscopy with transducers of 80 MHz and 250 MHz center frequencies. The results of calculation of SOS and attenuation were compared with histology of each tissue sample.

  47. 微小レベルにおける局所心筋の収縮-弛緩・伸展特性(位相差トラッキング法を用いた心筋壁動態解析)

    田渕晴名, 片平美明, 田中元直, 中島博行, 坂本二哉, 菅原重生, 亀山剛義, 長谷川英之, 金井浩, 西條芳文

    日本心エコー図学会学術集会抄録集　24th　2013

  48. 3Pb5-5 Measurement of Micro-displacement of Polyvinyl Alcohol Induced by Acoustic Radiation Force : Comparison of Laser-Doppler Velocimetry and High Frequency Ultrasound(Poster Session)

    Nagaoka Ryo, Izumi Takuya, Komatsu Yosuke, Kobayashi Kazuto, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　33　487-488　2012/11/13

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  49. 3Pa5-5 Development of blood flow velocity estimation method from Doppler echocardiography and its validation by MRI data(Poster Session)

    Kojima Takanori, Nakajima Hiroyuki, Kurokawa Takafumi, Kameyama Takeyoshi, Tabuchi Haruna, Omori Aiko, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　33　381-382　2012/11/13

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  50. Characterization of rat liver tissue by measuring the acoustic characteristics in high frequency

    INOUE Kenta, MAMOU Jonathan, KOBAYASHI Kazuto, SAIJO Yoshifumi, YAMAGUCHI Tadashi

    超音波エレクトロニクスの基礎と応用に関するシンポジウム講演予稿集　33rd　481-482　2012/11/13

    ISSN： 1348-8236

  51. Information on Rescue Activity

    SAIJO Yoshifumi

    The Journal of the Institute of Electronics, Information, and Communication Engineers　95　(10)　899-903　2012/10/01

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5693

  52. 難治性五十肩の病態

    萩原 嘉廣, 安藤 晃, 土谷 昌広, 高橋 憲正, 西條 芳文, 菅谷 啓之, 井樋 栄二

    日本整形外科学会雑誌　86　(8)　S1097-S1097　2012/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  53. Engineering analysis of the effects of bulging sinus in a newly designed paediatric pulmonary heart valve on hemodynamic function

    SUZUKI Ichiro, YABE Shota, MATSUE Ken, SUGAI Telma Keiko, TSUBOKO Yusuke, SAIJO Yoshifumi, YOSHIZAWA Makoto, KAMEYAMA Takeyoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, FENG Zhonggang, OKAMOTO Yoshihiro, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

    人工臓器　41　(1)　59-61　2012/06/15

    DOI： 10.1007/s10047-011-0609-1 　

    ISSN： 0300-0818

  54. 超音波顕微鏡観察における,金属イオン試薬添加を利用した観察法の検討

    小林和人, 吉田祥子, 穂積直裕, 西條芳文

    超音波医学　39　S358　2012/04/15

    ISSN： 1346-1176

  55. 左心房収縮と流入血による渦の発生

    山家智之, 亀山剛義, 秋野能久, 西條芳文, 田中元直

    日本臨床生理学会雑誌　42　(5)　2012

    ISSN： 0286-7052

  56. Blood Flow Structure in Patients with Dilated Cardiomyopathy Studied using Echo-dynamography

    亀山剛義, 山家智之, 白石泰之, 西條芳文, 田中元直

    日本臨床生理学会雑誌　42　(3)　2012

    ISSN： 0286-7052

  57. Engineering Analysis of the Effects of Bulging Sinus in a Newly Designed Paediatric Pulmonary Heart Valve on Hemodynamic Function

    鈴木一郎, 鈴木一郎, 矢部翔太, 末永健, SUGAI Telma Keiko, 坪子侑佑, 西條芳文, 吉澤誠, 亀山剛義, 白石泰之, 山家智之, 馮忠剛, 岡本吉弘, 田中隆, 梅津光生, 宮崎隆子, 山岸正明

    東北医学雑誌　124　(1)　2012

    ISSN： 0040-8700

  58. 左室乳頭筋モデルによる僧帽弁機能の基礎検討

    橋本尚, 白石泰之, SUGAI Telma Keiko, 志賀卓弥, 古賀千尋, 山田昭博, 坪子侑佑, 三浦英和, 西條芳文, 山家智之, 本間大

    生体医工学　50　(4)　2012

    ISSN： 1347-443X

  59. 超音波顕微鏡を用いた心筋症診断の可能性

    中村陽一, 小林和人, 草野研吾, 穂積直裕, 西條芳文

    日本心エコー図学会学術集会抄録集　23rd　90　2012

  60. 1P1-1 Photoacoustic imaging of knee cartilage mouse using а semiconductor laser(Poster Session)

    Izumi Takuya, Miida Yusuke, Nagaoka Ryo, Sato Mika, Matsuura Yuji, Hagiwara Yoshihiro, Saijo Yoshifumi

    Proceedings of Symposium on Ultrasonic Electronics　33　(0)　19-20　2012

    Publisher: Institute for Ultrasonic Elecronics

    DOI： 10.24492/use.33.0_19 　

    ISSN： 1348-8236

  61. 2Pa5-13 Acoustic characteristics measurement of rat liver by multi-frequency ultrasound(Poster Session)

    TAKEUCHI Yoichiro, NARISAWA Ryo, HACHIYA Hiroyuki, SAIJO Yoshifumi, KOBAYASHI Kazuto, YAMAGUCHI Tadashi

    Proceedings of Symposium on Ultrasonic Electronics　32　159-160　2011/11/08

    Publisher: Steering committee of symposium on ultrasonic electronics

    ISSN： 1348-8236

  62. 中空光ファイバを用いた光音響イメージングと光音響効果の色依存性

    小池秀幸, 熊谷和敏, 和泉拓哉, 三井田佑輔, 穂積直裕, 松浦祐司, 西條芳文

    超音波医学　38　S463　2011/04/15

    ISSN： 1346-1176

  63. Aberration Correction for Biological Acoustic Impedance Microscope and Observation of Rat Cerebella Tissue

    UEMURA Tsutomu, SUZUKI Takaya, HANAI Kunihiko, HOZUMI Naohiro, KOBAYASHI Kazuto, YOSHIDA Sachiko, YAMAMOTO Seiji, SAIJO Yoshifumi

    電気学会研究会資料. DEI, 誘電・絶縁材料研究会　2011　(1)　53-56　2011/01/19

  64. 8F-07 Preliminary study on the effect of papillary tension on valvular leakage for the development of a new artificial papillary muscle using shape memory alloy fiber

    HASHIMOTO Hisashi, SHIRAISHI Yasuyuki, SUGAI Telma KEIKO, KONNO Satoshi, MIURA Hidekazu, SAIJO Yoshifum, YAMBE Tomoyuki, HOMMA Dai

    2010　(23)　109-110　2011/01/07

    Publisher: The Japan Society of Mechanical Engineers

  65. 医用超音波イメージング最近の展開

    西條 芳文, 田上 英毅, 中島 博行

    ナノ医工学年報　5　(1)　131-140　2011

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  66. 情報通信技術 (ICT) は医療福祉問題の救世主か？

    吉澤 誠, 杉田 典大, 阿部 誠, 西條 芳文, 本間 経康, 金野 敏, 山家 智之, 仁田 新一

    生体医工学　49,　(2)　387-389　2011

    Publisher: 日本生体医工学会

    DOI： 10.11239/jsmbe.49.387 　

    ISSN： 1347-443X

  67. PP-576 超音波音速顕微鏡で観察した前立腺組織～予備的報告(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

    田上 英毅, 小林 和人, 西條 芳文, 萩原 嘉廣, 浦田 洋二, 上田 朋宏

    日本泌尿器科学会雑誌　102　(2)　500-500　2011

    Publisher: 一般社団法人 日本泌尿器科学会

    DOI： 10.5980/jpnjurol.102.500_1 　

    ISSN： 0021-5287

  68. Preliminary study on the development of a new artificial papillary muscle using shape memory alloy fiber

    HASHIMOTO Hisashi, SHIRAISHI Yasuyuki, SUGAI Telma Keiko, KONNO Satoshi, MIURA Hidekazu, SAIJO Yoshifum, YAMBE Tomoyuki, HOMMA Dai

    2010　(45)　13-16　2010/11/20

  69. 高分子フィルム型超音波振動子のインパルス応答を利用した脳腫瘍の観察と画像処理

    鈴木貴也, 花井邦彦, 植村努, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気電子絶縁材料システムシンポジウム　2010/11

  70. セラミック超音波振動子による細胞観察

    花井邦彦, 植村努, 鈴木貴也, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気電子絶縁材料システムシンポジウム　2010/11

  71. REVERSIBILITY OF IMMOBILIZATION-INDUCED ARTICULAR CARTILAGE DEGENERATION AFTER REMOBILIZATION IN RAT KNEE JOINTS

    A. Ando, H. Suda, Y. Hagiwara, Y. Onoda, E. Chimoto, Y. Saijo, E. Itoi

    OSTEOARTHRITIS AND CARTILAGE　18　S92-S93　2010/10

    ISSN： 1063-4584

  72. 超音波によるラットの脳腫瘍モデルの観察と定量解析

    鈴木貴也, 植村努, 花井邦彦, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気関係学会東海支部連合大会講演論文集(CD-ROM)　2010　ROMBUNNO.B2-9　2010/08/27

  73. 生体観察用光音響顕微鏡のための高速スキャンシステム開発

    小池秀幸, 熊谷和敏, 穂積直裕, 植村努, 松浦祐司, 西條芳文

    超音波医学　37　S347　2010/04/15

    ISSN： 1346-1176

  74. 三次元複合臓器構造体研究開発における高周波数超音波の応用

    西條 芳文, 萩原 嘉廣, 羽鳥 弘毅, 小林 和人, 穂積 直裕, 田中 明, 中村 憲正, 星 和人

    超音波医学　37　(Suppl.)　S346-S346　2010/04

    Publisher: (一社)日本超音波医学会

    ISSN： 1346-1176

  75. 超音波によるラットの脳腫瘍モデルの観察と画像処理

    鈴木貴也, 植村努, 花井邦彦, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2010　(1)　153　2010/03/05

  76. 2次元音響インピーダンス測定機能付き3次元超音波顕微鏡を実現するための複合焦点振動子

    花井邦彦, 植村努, 鈴木貴也, 穂積直裕, 小林和人, 吉田祥子, 山本清二, 西條芳文

    電気学会全国大会講演論文集　2010　(1)　154　2010/03/05

  77. 0406 Preliminary examination of an engineering control for hemodynamic assistance by the artificial myocardium using shape memory alloy fibre

    SATO Yuta, UMEZU Mitsuo, FUJIMOTO Tatsuo, SHIRAISHI Yasuyuki, MIURA Hidekazu, KONNO Satoshi, YAMBE Tomoyuki, KANEKO Yoshikazu, SUGAI Telma Keiko, YABE Shota, SAIJO Yoshifumi, BABA Atsushi, Homma Dai

    2009　(22)　58-58　2010/01/08

    Publisher: The Japan Society of Mechanical Engineers

  78. Bulging sinusを有するePTFE心臓代用弁の工学的評価

    白石泰之, 鈴木一郎, 矢部翔太, SUGAI Telma K, 山田昭博, 亀山剛義, 金子芳一, 北野智哉, 田中隆, 金野敏, 西條芳文, 梅津光生, 宮崎隆子, 山岸正明, 山家智之

    人工臓器(日本人工臓器学会)　39　(2)　2010

    ISSN： 0300-0818

  79. Effect of Feedback of Zeroed Doppler Velocity on Ultrasonic-Measurement-Integrated Simulation of Blood Flow

    Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

    2010　216-216　2010

    Publisher: 日本流体力学会

    More details Close

    Ultrasonic-measurement-integrated (UMI) simulation, in which feedback signals are applied to the governing equations based on errors between ultrasonic measurement and numerical simulation, has been investigated for reproduction of the blood flow field. In this study, the effects of wall filter and lack of data, which provide zero Doppler velocity, on UMI simulation were examined by a numerical experiment dealing with the blood flow field in the descending aorta with an aneurysm. Effects of wall filter and lack of data appeared in diastole and in the whole period, respectively. However, by not adding feedback signals where measured Doppler velocities were zero, the computational accuracy of the UMI simulation substantially improved for the sake of the feedback.

  80. ｢超｣常識｢超｣音波イメージングの医学・生物学への応用

    西條 芳文, 小林 和人, 田上 英毅

    ナノ医工学年報　4　(1)　123-130　2010

    Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」

    ISSN： 1882-4692

  81. A102 Evaluation of hemodynamic characteristics of the newly designed paediatric pulmonary heart valve by using a high speed video camera

    YABE Shota, SUZUKI Ichiro, Sugai Telma Keiko, SAIJO Yosifumi, MIURA Hidekazu, LIU Hong Jian, KONNO Satoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　5-6　2009/11/06

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  82. B213 Blood Flow Simulation Integrated with Ultrasonic Measurement 9^<th> Report : Effect of Noise in Ultrasonic Measurement

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2009　(20)　117-118　2009/11/06

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  83. Basic study on the sophisticated control for the intelligent artificial myocardium

    SHIRAISHI Yasuyuki, MIURA Hidekazu, YAMBE Tomoyuki, SUGAI Telma Keiko, SAIJO Yoshifumi, SATO Yuta, FUJIMOTO Tetsuo, UMEZU Mitsuo, BABA Atsushi, FUKUNAGA Kazuyoshi, TANAKA Akira, HOMMA Dai

    2009　(34)　37-42　2009/10/20

  84. 509 Basic characteristics of the newly designed paediatric pulmonary circulatory simulator

    YABE Shota, SUZUKI Ichiro, SUGAI Telma Keiko, SAIJO Yosifumi, MIURA Hidekazu, LIU Hong Jian, KONNO Satoshi, SHIRAISHI Yasuyuki, YAMBE Tomoyuki, TANAKA Takashi, UMEZU Mitsuo, MIYAZAKI Takako, YAMAGISHI Masaaki

    2009　(45)　145-146　2009/09/26

    Publisher: The Japan Society of Mechanical Engineers

  85. 508 Preliminary study on the new bioengineering approach for surgical planning of ventricular reconstruction

    SHIRAISHI Yasuyuki, LIN Hui, SUGAI Telma Keiko, UEMATSU Miyuki, SAIJO Yoshifumi, TANAKA Akira, UMEZU Mitsuo, YAMBE Tomoyuki, TABAYASHI Koichi

    2009　(45)　143-144　2009/09/26

    Publisher: The Japan Society of Mechanical Engineers

  86. 三次元高周波数超音波イメージングによる皮膚組織の微細構造の観察

    西條芳文, 小林和人, 田中明, 穂積直裕

    超音波医学　36　S301　2009/04/15

    ISSN： 1346-1176

  87. 生体組織の固有音響インピーダンスを評価するための簡易計測プローブの提案

    小林和人, 森屋健司, 穂積直裕, 西條芳文

    超音波医学　36　S294　2009/04/15

    ISSN： 1346-1176

  88. パラフィン包埋標本作成過程において組織音速に影響を及ぼす因子の検討

    中村 陽一, 小林 和人, 中村 一文, 草野 研吾, 穂積 直裕, 吉田 祥子, 鈴木 誠, 西條 芳文

    超音波医学　36　(Suppl.)　S293-S293　2009/04

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  89. PJ-061 Visualization of Micro-vessel by Three-dimensional Ultrasound Microscope(PJ010,Echo/Doppler (New Technology) 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Saijo Yoshifumi, Kobayashi Kazuto, Tanaka Akira

    Circulation journal : official journal of the Japanese Circulation Society　73　561-561　2009/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  90. OE-076 Ultrasonic Tissue Deformation Imaging to Evaluate Myocardial Dyssynchrony(OE13,Echo/Doppler (New Technology) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

    Saijo Yoshifumi, Tanaka Akira

    Circulation journal : official journal of the Japanese Circulation Society　73　193-193　2009/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  91. 多次元の血圧反射機能感受性定量診断 (心臓リハビリテーション)

    山家智之, 金野敏, 西條芳文, 白石泰之, 仁田新一, 上月正博, 吉澤誠, 杉田典大, 田中明, 山口済, 片平美明, 秋野能久, 柴田宗一, 渡辺誠, 三引義明, 大沢上, 佐藤尚

    心臓リハビリテーション　14　(1)　108-114　2009/02

  92. 橈骨動脈血流量に関する鍼治療の効果 太衝穴による血行動態変化

    高山 真, 関 隆志, 山家 智之, 西條 芳文, 金野 敏, 沖津 玲奈, 岩崎 鋼, 荒井 啓行, 八重樫 伸生, 仁田 新一

    日本内科学会雑誌　98　(Suppl.)　218-218　2009/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  93. 139 Mechanical design of the totally implantable artificial myocardial assist device by using shape memory alloy fibre

    SHIRAISHI Yasuyuki, SAKATA Ryo, SATO Yuta, KONNO Satoshi, SUGAI Telma Keiko, BABA Atsushi, FUJIMOTO Tetsuo, UMEZU Mitsuo, IMACHI Kou, SAIJO Yoshifumi, YAMBE Tomoyuki, Homma Dai

    2008　(21)　307-308　2009/01/22

    Publisher: The Japan Society of Mechanical Engineers

  94. 326 Blood Flow Simulation Integrated with Ultrasonic Measurement 8th Report : Effect of Error in Ultrasonic Measurement

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    2008　(21)　353-354　2009/01/22

    Publisher: The Japan Society of Mechanical Engineers

  95. 流軸線上速度勾配測定法による左室拡張能評価(第一報)-Echo-dynamographyによる解析-

    中島博行, 田中元直, 菅原重生, 片平美明, 亀山剛義, 大槻茂雄, 西條芳文

    日本心エコー図学会学術集会抄録集　20th　2009

  96. 左室内におけるLate Systolic Reversal Flow-Echo-Dynamographyによる血流解析-

    亀山剛義, 菅原重生, 片平美明, 田中元直, 中島博行, 大槻茂雄, 西條芳文

    日本心エコー図学会学術集会抄録集　20th　2009

  97. 流軸線上速度分布による定量的心機能評価法の検討(第二報)

    中島博行, 田中元直, 菅原重生, 片平美明, 亀山剛義, 大槻茂雄, 西條芳文

    超音波医学　36　2009

    ISSN： 1346-1176

  98. 脈のない人工心臓と，脈の診断

    山家 智之, 白石 泰之, 金野 敏, 馬場 篤志, 井街 宏, 田林 晄一, 西條 芳文, 杉田 典大, 吉沢 誠, 上月 博, 阿部 裕輔, 斎藤 逸郎, 磯山 隆, 山崎 健二, 北野 智哉, 山崎 俊一, 亀山 剛義, 秋野 能久, 山口 済, 片平 美明, 柴田 宗一, 大沢 上, 佐藤 尚

    宮城県医師会報　755　12　2008/12/01

  99. 23) 左心補助人工心臓から離脱した拡張型心筋症の1例(第146回日本循環器学会東北地方会)

    井口 篤志, 二宮 本報, 田林 晄一, 西條 芳文

    Circulation journal : official journal of the Japanese Circulation Society　72　1054-1054　2008/10/20

    Publisher: 社団法人日本循環器学会

    ISSN： 1346-9843

  100. 1E3-5 Improvement of the artificial myocardial assistance for chronic animal experiment

    SATO Yuta, SHIRAISHI Yasuyuki, SAKATA Ryo, LIN Hui, TANAKA Takashi, UMEZU Mitsuo, KONNO Satoshi, SAIJO Yoshifumi, SUGAI Telma Keiko, YOSHIZAWA Makoto, YAMBE Tomoyuki, BABA Atsushi, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, Homma Dai

    The JSME Symposium on Welfare Engineering　2008　135-136　2008/09/17

    Publisher: The Japan Society of Mechanical Engineers

  101. 超音波顕微鏡の培養細胞への応用

    萩原嘉廣, 西條芳文, 安藤晃, 千本英一, 小野田祥人, 須田英明, 井樋栄二

    日本整形外科学会雑誌　82　(8)　S1018-S1018　2008/08/25

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  102. 皮膚組織の3次元超音波顕微鏡像

    西條芳文, 岩本貴宏, 小林和人, 岡田長也, 萩原嘉廣, 田中明, 穂積直裕

    超音波医学　35　(4)　469　2008/07/15

    ISSN： 1346-1176

  103. Present status of medical application of acoustic microscopy

    SAIJO Yoshifumi

    The Journal of the Acoustical Society of Japan　64　(7)　418-422　2008/07/01

    Publisher: The Acoustical Society of Japan (ASJ)

    ISSN： 0369-4232

  104. Quantitative analysis of the regional myocardial function by the velocity distribution of flow axis line

    NAKAJIMA Hiroyuki, SUGAWARA Shigeo, KATAHIRA Yoshiaki, TANAKA Motonao, KAMEYAMA Takeyoshi, OHTUKI Shigeo, SAIJO Yoshifumi

    35　S359　2008/04/15

    ISSN： 1346-1176

  105. High frequency ultrasonic imaging

    SAIJO Yoshifumi

    35　S185　2008/04/15

    ISSN： 1346-1176

  106. 637 Mechanical analysis of morphological structure of a heart for more sophisticated design of the artificial myocardium

    SHIRAISHI Yasuyuki, SAIJO Yoshifumi, YAMBE Tomoyuki, SHIBATA Muneichi, WADA Yumiko, SAKATA Ryo, WATABE Tomoki, UMEZU Mitsuo, FUJIMOTO Tetsuo, BABA Atsushi, TABAYASHI Koichi, Homma Dai

    2007　(20)　433-434　2008/01/24

    Publisher: The Japan Society of Mechanical Engineers

  107. Artificial Myocardial Assistance using the Sophisticated Shape Memory Alloy Fibre Based on Engineering Approach for Cardiac Mechanics

    SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SAIJO Yoshifumi, SHIBATA Muneichi, MASUDA Shinya, TABAYASHI Koichi, UMEZU Mitsuo, HOMMA Dai

    電気学会研究会資料. LD, リニアドライブ研究会　2007　(32)　85-88　2007/10/25

  108. A111 Mechanical simulation for myocardial contractile assistance based on controllability of a sophisticated shape memory alloy fibre

    SAKATA Ryo, SHIRAISHI Yasuyuki, WADA Yumiko, WATABE Tomoki, UEMATSU Miyuki, TANAKA Takashi, PARK Young Kwang, UMEZU Mitsuo, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2007　(18)　21-22　2007/10/05

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  109. Propagation of electric excitation in human heart is visualized by transthoracic echocardiography

    Hiroshi Kanai, Yoshifumi Saijo

    CIRCULATION　116　(16)　501-502　2007/10

    ISSN： 0009-7322

  110. ラット膝関節不動化モデルにおける関節包組織の音速(粘弾性)の経時的変化

    萩原嘉廣, 千本英一, 安藤晃, 西條芳文, 笹野泰之, 井樋栄二

    日本整形外科学会雑誌　81　(8)　S1041-S1041　2007/08/25

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  111. (J Vasc Med)

    Saijo Yoshifumi

    J Vasc Med　3　(3)　45-52　2007/07/01

  112. Clinical application of parametric IVUS imaging (Jap J Cardiovasc Cathet Therap)

    Saijo Yoshifumi

    Jap J Cardiovasc Cathet Therap　7　(2)　131-139　2007/06

  113. Acoustic Impedance Microscopy for Tissue Characterization

    KOBAYASHI Kazuto, HOZUMI Naohiro, SAIJO Yoshifumi, YOSHIDA Sachiko, OHTSUKI Shigeo

    Journal of medical ultrasonics = 超音波医学　34　S324　2007/04/15

    ISSN： 1346-1176

  114. Image Processing for Ultrasonic Microscope Considering Its Beam Characteristics

    KOBAYASHI Kazuto, ISHIGURO Toshimichi, HOZUMI Naohiro, SAIJO Yoshifumi, OHTSUKI Shigeo

    Journal of medical ultrasonics = 超音波医学　34　S313　2007/04/15

    ISSN： 1346-1176

  115. Visualization of Fibroblast by in vivo Ultrasonic Nano-imaging

    SAIJO Yoshifumi, HOZUMI Naohiro, KOBAYASHI Kazuto, DOS SANTOS FILHO Esmeraldo

    Journal of medical ultrasonics = 超音波医学　34　S310　2007/04/15

    ISSN： 1346-1176

  116. PE-059 Two-dimensional Blood Flow Vector Imaging of Retardant Flow in Left Atrium(Echo/Doppler-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Saijo Yoshifumi, Tanaka Akira, Yambe Tomoyuki

    Circulation journal : official journal of the Japanese Circulation Society　71　339-340　2007/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  117. OE-089 Development of IVUS Attenuation Imaging and Comparison with Multiple Parametric Imagings(Intravascular endoscopy/Intravascular ultrasound-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

    Saijo Yoshifumi, Tanaka Akira, Filho Esmeraldo dos Santos, Iwamoto Takahiro, Yambe Tomoyuki

    Circulation journal : official journal of the Japanese Circulation Society　71　173-174　2007/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  118. 医用超音波ナノ・イメージング ＝周波数500MHzの医学用超音波音速顕微鏡の開発＝ (超音波TECHNO)

    SAIJO Yoshifumi

    超音波TECHNO　19　(1)　4-9　2007/01/20

    Publisher: 日本工業出版

    ISSN： 0916-2410

  119. 309 Blood Flow Simulation Integrated with Ultrasonic Measurement : 7^<th> Report: Effect of Time Resolution of Measurement

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    2006　(19)　68-69　2007/01/06

    Publisher: The Japan Society of Mechanical Engineers

  120. 人工心筋収縮構造制御による補助効率最適化に関する基礎検討

    白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 梅津光生, 小川大祐, 佐藤文博, 角張泰之, 田中明, 吉澤誠, 本間大

    日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　2007

  121. 形状記憶合金を応用した消化管蠕動運動補助装置

    関根一光, 山家智之, 西條芳文, 白石泰之, 松木英敏, 佐藤文博, 角張泰之, 前田剛, 中澤文男

    日本生体医工学会大会プログラム・論文集(CD-ROM)　46th　2007

  122. 生体心臓の構造を考慮した人工心筋開発の試み

    白石泰之, 山家智之, 関根一光, 西條芳文, 金野敏, 仁田新一, 和田由美子, 坂田亮, 伊藤慎二, 植松美幸, PARK Youngkwang, 田中隆, 梅津光生, 小川大祐, 角張泰之, 佐藤文博, 田中明, 吉澤誠, 増本憲泰, 藤本哲男, 本間大, 馬場敦, 井街宏, 佐々田比呂志, 田林晄一

    バイオエンジニアリング講演会講演論文集　19th　2007

    ISSN： 1348-2920

  123. Ultrasound speed and impedance microscopy for in vivo imaging. International-journal

    Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Toshimichi Ishiguro, Yoshihiro Hagiwara, Esmeraldo dos Santos Filho, Tomoyuki Yambe

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference　2007　1350-3　2007

    ISSN： 1557-170X

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    Ultrasound speed and impedance microscopy was developed in order to develop in vivo imaging system. The sound speed mode realized non-contact high resolution imaging of cultured cells. This mode can be applied for assessment of biomechanics of the cells and thinly sliced tissues. The impedance mode visualized fine structures of the surface of the rat's brain. This mode can be applied for intra-operative pathological examination because it does not require slicing or staining.

  124. 340 Development of linear actuator as a peristaltic motion assist device

    Sekine Kazumitsu, Nakazawa Fumio, Shiraishi Yasuyuki, Yambe Tomoyuki, Saijo Yoshifumi, Ohta Makoto, Hori Yoshio, Matsuki Hidetoshi, Sato Fumihiro, Maeda Tsuyoshi

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2006　(0)　336-337　2007

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2006.19.336 　

  125. ラット膝関節不動化モデルにおける関節包組織の粘弾性の経時的変化

    萩原嘉廣, 千本英一, 安藤晃, 西條芳文, 笹野泰之, 国分正一, 井樋栄二

    日本結合組織学会学術大会抄録集　39th　133　2007

  126. B102 Design improvement of a newly designed artificial myocardial belt

    WADA Yumiko, SHIRAISHI Yasuyuki, ITOH Shinji, SAKATA Ryo, UEMATSU Miyuki, TANAKA Takashi, PARK Young Kwang, UMEZU Mitsuo, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, Nitta Shinichi, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2006　(17)　43-44　2006/11/10

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  127. 1306 Numerical Experiment of Ultrasonic-Measurement-Integrated Simulation for Three-Dimensional Unsteady Blood Flow(1)

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    Fluids engineering conference ...　2006　"1306-a"　2006/10/28

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2882

  128. Development of peristaltic motion assist device for using helicoidal shape memory alloy against digestive organs cancer

    SEKINE Kazumitsu, YAMBE Tomoyuki, SHIRAISHI Yasuyuki, SAIJO Yoshifumi, HORI Yoshio, MATSUKI Hidetoshi, SATO Fumihiro, NITTA Shin-ichi, MAEDA Tsuyoshi

    2006　(48)　69-73　2006/10/26

  129. 特集 DES時代のBeyond Angiography Virtual Histologyの基礎 (Coronary Intervention )

    西條芳文

    Coronary Intervention　2　(1)　82-87　2006/05

  130. 拡張型心筋症における心筋音速とIntegrated Backscatterとの関係

    中村陽一, 高橋昇, 小松須美生, 小林和人, 穂積直裕, 西条芳文, 中村一文, 草野研吾, 大江透

    超音波医学　33　S540　2006/04/15

    ISSN： 1346-1176

  131. 100MHz超音波による肝組織の3次元イメージング

    西条芳文, 岡田長也, 小林和人, 穂積直裕, SANTOS FILHO Esmeraldo Dos, 白石泰之, 関根一光, 山家智之

    超音波医学　33　S315　2006/04/15

    ISSN： 1346-1176

  132. 心筋の弾性からみた新しい病理組織診断の試み‐超音波顕微鏡を用いた検討‐

    中村陽一, 高橋昇, 小松須美生, 大郷恵子, 中村一文, 小林和人, 穂積直裕, 西条芳文, 草野研吾, 大江透

    循環器科　59　(3)　303　2006/03/28

    ISSN： 0388-1911

  133. 生体組織用超音波顕微鏡のためのエコー成分推定法

    田中直彦, 小林和人, 穂積直裕, 西条芳文, 田中元直, 大槻茂雄

    超音波医学　33　(2)　256　2006/03/15

    ISSN： 1346-1176

  134. FRS-093 Automatic Segmentation of IVUS Image by Self-organizing Map(Visualization of Atherosclerotic Plaque (I) FRS19,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

    Saijo Yoshifumi, Tanaka Akira, Akino Yoshihisa, Hanadate Yasushi, Yambe Tomoyuki

    Circulation journal : official journal of the Japanese Circulation Society　70　136-136　2006/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  135. Development of ultrasound-speed microscope for biological tissue characterization driven by nano-second pulse

    KOBAYASHI Kazuto, HOZUMI Naohiro, SAIJO Yoshifumi, OHTSUKI Shigeo

    The Journal of the Acoustical Society of Japan　62　(3)　148-152　2006/03/01

    Publisher: 一般社団法人日本音響学会

    DOI： 10.20697/jasj.62.3_148 　

    ISSN： 0369-4232

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    医学生物学分野における超音波顕微鏡の応用として,100〜200MHzのバースト波を用い組織試料の表裏面からの反射の干渉を利用した組織音響特性(音速・減衰)の計測法が提案されていたが,計測時間短縮や装置の小型化の要求があった。我々は広帯域のパルス波を用いた計測法を提案し,効率的な測定を行うことを可能とした。実用化にあたり装置の高速化のために機械走査と測定信号転送方法を検討しパーソナルコンピュータとマイコン,専用回路を組み合わせ,それぞれが持つ特長を最大限に生かしたハイパフォーマンスなシステムを構築した。

  136. In vivo Observation for Biological Tissue by Acoustic Impedance Microscope

    KIMURA, TERAUCHI S, MURAKAMI Y, HOZUMI N, NAGAO M, YOSHIDA S, KOBAYASHI K, SAIJO Y

    IEICE technical report　105　(553)　25-29　2006/01/19

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

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    We have proposed a new method for two-dimensional acoustic impedance imaging for biological tissue that can perform micro-scale observation without preparing a sliced specimen. A tissue was attached on a plastic plate of 0.5 mm in thickness. An acoustic pulse with a frequency range up to 100 MHz was transmitted from the &quot;rear side&quot; of the plate, the acoustic beam being focused at the boundary between the tissue and plate. The reflection intensity was interpreted into local acoustic impedance of the target tissue. An acoustic impedance microscopy with 200 x 200 pixels, its view port being 2 x 2 mm, was obtained by mechanically scanning the transducer. Quantification of acoustic impedance was performed using water or an appropriate material as a reference. The accuracy was assessed by using salt water. As for an observation, a rat cerebellum was employed. The development of parallel fiber in cerebella cultures was clearly observed as the contrast in acoustic impedance. The proposed technique is believed to be a powerful tool for biological tissue characterization, as neither staining nor slicing is required.

  137. 223 Effect of Anisotropic Feedback Points Arrangement in Three-dimensional Ultrasonic-Measurement-Integrated Simulation

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    2005　(18)　105-106　2006/01/12

    Publisher: The Japan Society of Mechanical Engineers

  138. 経食道心エコーによる左室補助装置装着患者の心機能評価

    西條芳文, 齋木佳克, 井口篤志, 田林晄一, 白石泰之, 関根一光, 山家智之

    日本生体医工学会大会プログラム・論文集　45th　2006

    ISSN： 1347-443X

  139. 左心補助装置装着症例の術中経食道心エコー所見

    西條芳文, 齋木佳克, 井口篤志, 田林晄一, 白石泰之, 関根一光, 山家智之

    日本心エコー図学会学術集会抄録集　17th　2006

  140. 特集 DES時代のBeyond Angiography Virtual Histologyの基礎． (Coronary Intervention )

    Saijo Yoshifumi

    Coronary Intervention　2　(1)　82-87　2006/01

  141. Fundamental Study on the Development of a Diagnostic System for Left Ventricular Plastic Surgery of the Abscission Area

    UEMATSU Miyuki, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, YAMBE Tomoyuki, SAIJO Yoshifumi, ANDO Hayato, PARK Young-Kwang, TAKEDA Sunao, IWASAKI Kiyotaka, UMEZU Mitsuo

    Transactions of the Japanese Society for Medical and Biological Engineering : BME　43　(4)　653-660　2005/12/10

    Publisher: Japanese Society for Medical and Biological Engineering

    ISSN： 1347-443X

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    Ventricular aneurysm is one of the complications that follow a myocardial infarction. Left ventricular (LV) plastic and reconstructive surgery, Dor procedure, is widely performed in order to improve patients' cardiac functions. However, it is anticipated that the abscission region of the ventricle might cause some complications, such as mitral valve regurgitation. Therefore, the decision of what to be done with that area might affect therapeutic consequences. In this study, the authors have developed a measurement system for surface movement and a display system to demonstrate decreased LV systolic function during surgery. This system is capable of evaluating the cardiac function using displacement data obtained from superficial motion of the specific regions. Prior to measurement, the reflective ball markers were sutured on the surface of the heart without any complications or infarctions. The point of the markers indicated the anatomically specific points, such as apex, septum, mitral valve, and papillary muscles. The location of points was sequentially measured by an optical three-dimensional location sensor. The superficial area of the left ventricle from the left thoracotomy view was divided into 12 triangular regions each composed of three markers. As the contraction of the regional area corresponds to the cardiac systolic function, the changes in each area were examined. The contraction rate of the heart was superimposed onto the video images of a natural heart, which were obtained simultaneously. An animal study was performed to compare heart functions under a normal pulsating state and during the time of a myocardial infarction. The physical data such as electrocardiogram, blood flow and pressure were simultaneously obtained and compared using this approach. With the physical data, it was confirmed that strain change in the regional area was coincident with a contraction of the actual heart. It was also found that this method is simple enough to set up in the operation theater. In the near future, this method will contribute widely to the clinical diagnoses of patients, when advanced surgery such as robot surgery and/or organ transplant become popular.

  142. B117 Development of a totally-implantable artificial myocardium using a shape memory alloy fiber

    NAGATOSHI Jun, ITOH Shinji, UEMATSU Miyuki, TANAKA Takashi, UMEZU Mitsuo, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, TANAKA Akira, YOSHIZAWA Makoto, MASUMOTO Noriyasu, FUJIMOTO Tetsuo, HOMMA Dai

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　77-78　2005/11/08

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  143. B205 Blood Flow Simulation Integrated with Ultrasonic Measurement : 5^<th> Report: Reproduction of Three-dimensional Unsteady Blood Flow Field

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2005　(16)　137-138　2005/11/08

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  144. 907 Evaluation of Effectiveness of Feedback Formulae in Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

    Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

    Fluids engineering conference ...　2005　139-139　2005/10/28

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2882

  145. A New Method for the Evaluation of the Heart Function by Surface Measurement

    UEMATSU Miyuki, SHIRAISHI Yasuyuki, SEKINE Kazumitsu, YAMBE Tomoyuki, SAIJO Yoshifumi, MUTO Shunsuke, PARK Young-Gang, ANDO Hayato, MATSUMOTO Toru, TAKEDA Sunao, IWASAKI Kiyotaka, UMEZU Mitsuo, UCHIYAMA Akihiko

    2005　(1)　23-26　2005/07/19

  146. Estimation of echo component in sound speed microscopy for biological tissue

    TANAKA Naohiko, KOBAYASHI Kazuto, HOZUMI Naohiro, SAIJO Yoshifumi, TANAKA Motonao, OHTSUKI Shigeo

    IEICE technical report. Ultrasonics　105　(135)　21-26　2005/06/17

    Publisher: 一般社団法人電子情報通信学会

    ISSN： 0913-5685

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    Ultrasonic sound speed microscopy is a useful tool for tissue characterization. The sound speed of sliced tissue sample is determined by the propagation delay time of the echoes reflected at the front and rear surfaces of tissue sample. In practice there is a difficulty that these echoes overlap each other, and unnecessary echoes which is caused by multiple reflection are also overlapped. This paper propose an estimation technique of multiple echo component for the determination of sound speed. The proposed technique is applied to the measurement data obtained by the ultrasonic microscopy using 80MHz transmission pulse, and the performance of echo estimation is confirmed.

  147. ALTERNATIVE MAGNETIC STIMULATION ON PERIPHERAL CIRCULATION FOR REGENERATIVE MEDICINE

    YAMBE T., SEKINE K., SHIRAISHI Y., SAIJO Y, KONNO S., MARUYAMA M., NITTA S, TABAYASHI K., INOUE A

    25　(1)　10-10　2005/06/10

    ISSN： 0916-6238

  148. 医学用超音波音速顕微鏡の開発とその世界的展開

    西条芳文, 穂積直裕, 小林和人, 田中直彦, 福間功史, 佐々木英彦, 田中元直, 山家智之

    生体医工学　43　(2)　329　2005/06/10

    ISSN： 1347-443X

  149. 11. 医学用超音波音速顕微鏡の開発とその世界的展開(平成16年度東北支部大会抄録, 支部大会抄録)

    西條 芳文, 穂積 直裕, 小林 和人, 田中 直彦, 福間 功史, 佐々木 英彦, 田中 元直, 山家 智之

    生体医工学 : 日本エム・イー学会誌　43　(2)　2005/06/10

    Publisher: 社団法人日本生体医工学会

    ISSN： 1347-443X

  150. 血管内超音波(IVUS)の画像解析(3.2 第3回情報シナジー研究会, 3. 研究活動)

    田中 明, 西條 芳文, エスメラルド ドス サントス フィロ, 岩本 貴宏, 阿部 健一, 吉澤 誠

    年報　4　79-82　2005/05

    Publisher: 東北大学情報シナジーセンター

  151. Estimation of sound speed for ultrasonic microscopy

    TANAKA Naohiko, KOBAYASHI Kazuto, HOZUMI Naohiro, SAIJO Yoshifumi, OHTSUKI Shigeo

    Japanese journal of medical ultrasonics = 超音波医学　32　S303　2005/04/15

    ISSN： 1346-1176

  152. Comparison of Ultrasonic Sound Speed among Several Stage of Myocardial Degeneration

    NAKAMURA Yoichi, KOBAYASHI Kazuto, HOZUMI Naohiro, SAIJO Yoshifumi

    Japanese journal of medical ultrasonics = 超音波医学　32　S365　2005/04/15

    ISSN： 1346-1176

  153. Intravascular Two-dimensional Tissue Velocity Imaging of Vulnerable Plaque(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Saijo Yoshifumi, Tanaka Akira, Hirosaka Akira, Yoshizawa Makoto, Akino Yoshihisa, Yambe Tomoyuki

    Circulation journal : official journal of the Japanese Circulation Society　69　245-246　2005/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  154. Development of Speed of Sound Microscopy for Assessment of Tissue Elasticity of Coronary Artery(Echo/Doppler 8 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

    Saijo Yoshifumi, Hozumi Naohiro, Kobayashi Kazuto, Tanaka Motonao, Sasaki Hidehiko, Yambe Tomoyuki

    Circulation journal : official journal of the Japanese Circulation Society　69　295-295　2005/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  155. AM05-17-010 Effect of Feedback Points Arrangement on Accuracy of Three-dimensional Ultrasonic-Measurement-Integrated Simulation of Blood Flow

    Funamoto Kenichi, Hayase Toshiyuki, Saijo Yoshifumi, Yambe Tomoyuki

    2005　226-226　2005

    Publisher: 日本流体力学会

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    We have developed Ultrasonic-Measurement-Integrated (UMI) simulation to obtain detailed and accurate information of blood flow field numerically for the diagnosis or treatment of aneurysms. In this methodology, feedback signals derived from the difference between Doppler velocities by measurement and computation are fed back to the numerical simulation. In this study, we investigate the effect of feedback point arrangement on the computational accuracy of three-dimensional UMI simulation by numerical analysis. The result of UMI simulation converges to the standard solution in the feedback domain and in some extent of the downstream region of the feedback domain. The computational accuracy is more improved as the increment of feedback point density, while the necessary computational time for convergence is unchanged.

  156. Comparison of Brachial-Ankle Pulse Wave Velocity in Japanese and Russians

    LIU HONGJIAN, YAMBE TOMOYUKI, ZHANG XIUMIN, SAIJO YOSHIFUMI, SHIRAISHI YASUYUKI, SEKINE KAZUMITSU, MARUYAMA MITSUYA, KOVALEV YURI A., MILYAGINA IRINA A., MILYAGIN VIKTOR A., NITTA SHINICHI

    Tohoku J. Exp. Med.　207　(4)　263-270　2005

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.207.263 　

    ISSN： 0040-8727 1349-3329

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    Pulse wave velocity (PWV) is a well-known indicator of arterial stiffness and a marker of the presence of vascular lesions. Cardiovascular mortality in Russia has become the highest in the world. The Japanese are enjoying long lives, and the mortality caused by cardiovascular diseases has thus far remained at lower levels than that in Russia. In this study, we focused on brachial-ankle pulse wave velocity (baPWV) obtained from normal human subjects in Russia as well as in Japan, and compared their respective cardiovascular risks. We evaluated baPWV in 337 Japanese and 138 Russian healthy subjects. The baPWV was recorded using a PWV diagnosis device. BaPWV was measured between 2 locations of the arterial tree. The baPWV in the Russian group was significantly higher than that obtained in the Japanese of two groups categorized by age (40-59 years and 60- years). Further, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure in the Russian group were significantly higher than those obtained in Japanese in three age groups (under 39 years, 40-59 years, and 60- years). Moreover, the baPWV indicated a positive correlation with age, BMI and SBP in both Japanese and Russians, although the increasing trend of the baPWV against age of the Russian group had a larger value than that of the Japanese. Therefore, we suggest that arterial stiffness might be promoted earlier in the Russian group, which might be the main cause of the increased cardiovascular risk in Russia.

  157. Blood Flow Simulation Integrated with Ultrasonic Measurement 3^<rd> Report : Reproduction of Three-dimensional Blood Flow Field

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SAIJO Yoshifumi, YAMBE Tomoyuki

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2004　(15)　113-114　2004/11/04

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  158. Development of Echo-dynamography (Blood Flow Analysis by Acceleration Distribution Method)

    SUGAWARA Shigeo, TANAKA Motonao, YAMAGUCHI Tasuku, YAMANAKA Tamon, MIBIKI Yoshiaki, KATAHIRA Yoshiaki, NAKAJIMA Hiroyuki, OHTUKI Shigeo, SAIJO Yoshifumi

    31　S167　2004/04/15

    ISSN： 1346-1176

  159. Development of Echo-Dynamography

    NAKAJIMA Hiroyuki, TANAKA Motonao, SUGAWARA Shigeo, YAMAGUCHI Tasuku, YAMANAKA Tamon, MIBIKI Yoshiaki, KATAHIRA Yoshiaki, OHTUKI Shigeo, SAIJO Yoshifumi

    31　S168　2004/04/15

    ISSN： 1346-1176

  160. Two-dimensional tissue velocity distribution of coronary artery by intravascular ultrasound

    SAIJO Yoshifumi, TANAKA Akira, IWAMOTO Takahiro, SANTOS FILHO Dos Esmeraldo, YOSHIZAWA Makoto

    Journal of medical ultrasonics = 超音波医学　31　S166　2004/04/15

    DOI： 10.1016/j.ultras.2003.11.022 　

    ISSN： 1346-1176

  161. Medical application of scanning acoustic microscopy for sound speed measurement

    SAIJO Yoshifumi, KOBAYASHI Kazuto, SASAKI Hidehiko, FUKUMA Koushi, HOZUMI Naohiro, TANAKA Naohiko

    Journal of medical ultrasonics = 超音波医学　31　S121　2004/04/15

    ISSN： 1346-1176

  162. Ultrasonic-Measurement-Integrated Simulation for Blood Flows 2^<nd> Report : Reproduction of Blood Flow in Aorta

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

    2004　(16)　165-166　2004/01/21

    Publisher: The Japan Society of Mechanical Engineers

  163. 家兎棘上筋腱骨付着部の物理特性 超音波顕微鏡を用いた計測

    佐野博高, 西條芳文

    肩関節　28　(2)　209-213　2004

    DOI： 10.11296/katakansetsu1977.28.2_209 　

  164. B324 Study of Feedback Law for Ultrasonic-Measurement-Integrated Simulation of Blood Flow

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, SAIJO Yoshifumi, YAMBE Tomoyuki

    2004　538-539　2004

    Publisher: 日本流体力学会

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    In order to reproduce the blood velocity and pressure fields of the blood flow for an accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms, we integrate color Doppler ultrasonography and numerical simulation. We term this method as Ultrasonic-Measurement-Integrated (UMI) simulation. In the UMI simulation, feedback signals are added to the governing equations to compensate for the difference between computation and measurement. In this paper, we investigate effects of feedback law of the UMI simulation, such as feedback formulae, number and arrangement of monitoring points and the direction of ultrasonic beam for acquisition of Doppler velocity data, on the accuracy of the UMI simulation and computational time. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with inevitably incorrect upstream boundary conditions.

  165. 新しい人工心筋システムの開発

    白石 泰之, 山家 智之, 関根 一光, 西條 芳文, 渡邉 誠, 柴田 宗一, 山口 済, 王 慶田, 段 旭東, 劉 紅箭, 仁田 新一, 岡本 英治, 吉澤 誠, 田中 明, 小川 大祐, 佐藤 文博, 松木 英敏, 川野 聡恭, 羅 雲, 堀 義生, 田林 晄一, 高木 敏行, 早瀬 敏幸, 圓山 重直, 佐々田 比呂志, 梅津 光生, 本間 大

    日本AEM学会誌　12　(2)　87-93　2004

  166. パルス励起型超音波音速顕微鏡=FFT超音波音速顕微鏡=

    小林和人, 穂積直裕, 西条芳文

    超音波Techno　15　(6)　101-105　2003/11

    ISSN： 0916-2410

  167. Influence of Hypertension on Cardiac Function Examined by Echocardiography

    WATANABE Sachiko, SUZUKI Namiko, SUZUKI Tomoyuki, KUDO Atsuko, GOTOH Yuriko, SAIJO Yoshifumi

    52　(6)　795-800　2003/06/25

    ISSN： 0915-8669

  168. パルス波を用いる超音波顕微鏡のための組織音速推定法

    田中直彦, 小林和人, 穂積直裕, 西条芳文, 田中元直, 大槻茂雄

    超音波医学　30　S149　2003/04/15

    ISSN： 1346-1176

  169. パルス励起型超音波音速顕微鏡

    小林和人, 根本由記子, 穂積直裕, 西条芳文, 田中元直, 田中直彦, 大槻茂雄

    超音波医学　30　S146　2003/04/15

    ISSN： 1346-1176

  170. FFT超音波顕微鏡による心移植モデルの音響特性計測

    西条芳文, 佐々木英彦, 宮川利史, 穂積直裕, 小林和人, 大槻茂雄, 田中直彦, 田中元直, 仁田新一

    超音波医学　30　S175　2003/04/15

    ISSN： 1346-1176

  171. Tissue Characterization of Cardiovascular Tissues by High Frequency Ultrasound

    SAIJO Yoshifumi

    21　(2)　101-105　2003/03/25

    ISSN： 0288-450X

  172. Acoustic microscopy(Special Issue on Ultrasound Technology)

    SAIJO Yoshifumi, Yoshifumi SAIJO

    11　(1)　8-11　2003/03/10

    Publisher: 日本AEM学会

    ISSN： 0919-4452

  173. Development of a Pocket-Size Ultrasound Device Connected to the USB Port

    Saijo Yoshifumi, Kobayashi Kazuto, Arai Hitoshi, Nemoto Yukiko, Nitta Shin-ichi

    Circulation journal : official journal of the Japanese Circulation Society　67　346-346　2003/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  174. Intravascular Tissue Velocity Imaging

    Saijo Yoshifumi, Tanaka Akira, Owada Naoki, Akino Yoshihisa, Nitta Shin-ichi

    Circulation journal : official journal of the Japanese Circulation Society　67　349-349　2003/03/01

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  175. Ultrasonic-Measurement-Integrated Simulation for Blood Flows : 1^<st> Report : Reduction of Error Originating from Upstream Boundary Condition

    FUNAMOTO Kenichi, HAYASE Toshiyuki, SHIRAI Atsushi, YAMBE Tomoyuki, SAIJO Yoshifumi

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　1　83-84　2003

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-2939

  176. Motion Analysis of Arterial Wall Using Itravascular Ultrasound (IVUS) Image

    TANAKA Akira, YOSHIZAWA Makoto, ABE Ken-ichi, SAIJO Yoshifumi, NITTA Shin-ichi

    17　47-48　2002/09/09

  177. 高周波数超音波による心血管系の組織診断

    西条芳文, 田中元直, 仁田新一, 金井浩, 小林和人, 穂積直裕

    超音波医学　29　S188　2002/05/15

    ISSN： 1346-1176

  178. 痴呆モデルマウスにおける脳組織変性の音響特性

    西条芳文, 高井俊行, 海部知則, 菅原章子, 小林和人, 穂積直裕, 田中元直, 仁田新一

    超音波医学　29　S236　2002/05/15

    ISSN： 1346-1176

  179. Application of acoustic microscopy to assessment of cardiovascular biomechanics. (J Acoust Soc Am)

    Saijo Y, Sasaki H, Nitta S, Tanaka M, Joergensen CS, Falk E

    J Acoust Soc Am　112　(5)　2209　2002/04

  180. Differentiation of type I and III collagen in carotid plaques by high frequency ultrasound

    Saijo Yoshifumi, Nitta Shin-ichi, Jorgensen Claus

    Circulation journal : official journal of the Japanese Circulation Society　66　208-208　2002/03/31

    Publisher: Japanese Circulation Society

    ISSN： 1346-9843

  181. Influence of Aging on Cardiac Function Examined by Echocardiography

    WATANABE Sachiko, SUZUKI Namiko, KUDO Atuko, SUZUKI Tomoyuki, OHUCHI Mieko, GOTOH Yuriko, SAIJO Yoshifumi, MURAYAMA Nobuki

    29　(2)　J145-J151　2002/03/15

    ISSN： 1346-1176

  182. Single-Beat Estimation of E_<max> Based on Both Linearity of Ventricular Elastance and Constancy of Ventricular Dead Volume

    YOSHIZAWA Makoto, YOKOGAWA Megumi, TANAKA Akira, ABE Ken-ichi, SAIJO Yoshifumi, YAMBE Tomoyuki, NITTA Shin-ichi, KASS David A.

    16　45-48　2001/08/29

  183. Noninvasive Estimation of E_<max> Based on Aortic Flow Automatically Extracted from Doppler Echocardiography

    HIKOSAKA Takahiro, YOSHIZAWA Makoto, TANAKA Akira, ABE Ken-ichi, SAIJO Yoshifumi, YAMBE Tomoyuki, NITTA Shin-ichi

    16　49-52　2001/08/29

  184. Efficiency of intraoperative transesophageal echocardiography for lung transplantation

    SAIJO Y., OKADA Y., MATSUMURA Y., KONDO T., NITTA S.

    28　(3)　J464　2001/04/15

    ISSN： 1346-1176

  185. Scanning acoustic microscopy with GHz frequency ultrasound for biomedical use

    SAIJO Y., SASAKI H., NITTA S., TANAKA M., KOBAYASHI K.

    28　(3)　J394　2001/04/15

    ISSN： 1346-1176

  186. Evaluation of left ventricular function in the congestive heart failure by using Doppler-pressure

    SUGAWARA S., KATAHIRA Y., NITTA K., TANAKA M., NAKAJIMA H., NITTA S., SAIJO Y., OHTSUKI S.

    28　(3)　J374　2001/04/15

    ISSN： 1346-1176

  187. A Noninvasive Estimation Tool for Cardiac Function (E_<max> and PVA)

    YOSHIZAWA Makoto, HIKOSAKA Takahiro, TANAKA Akira, ABE Ken-ichi, SAIJO Yoshifumi, YAMBE Tomoyuki, NITTA Shin-ichi, KASS David A.

    15　189-192　2000/10/13

  188. Noninvasive Estimation of Left Ventricular Pressure Waveform

    KAWAGISHI Takefumi, YOSHIZAWA Makoto, TANAKA Akira, ABE Ken-ichi, SAIJO Yosifumi, YAMBE Tomoyuki, NITTA Shin-ichi

    15　185-188　2000/10/13

  189. 高周波振動流が下半身血管インピーダンスへ与える影響

    許 立慶, 山家 智之, 西條 芳文

    加齢医学研究所雑誌　51　(3)　121-130　2000/07

    Publisher: 東北大学加齢医学研究所研究会

    ISSN： 1340-3397

  190. Microscopy. (Ultrasound Med Biol)

    Saijo Y, Chubachi N

    Ultrasound Med Biol　26 Suppl 1　S30-2　2000/05

  191. Medical Ultrasonics in 21^<st> Century-Ultrasonic Communication with Cells-

    SAIJO Y.

    27　(4)　739-739　2000/04/15

    ISSN： 1346-1176

  192. Quantitative analysis of the vortex by the Flow-Function-Method

    SUGAWARA S., KATAHIRA Y., NITTA K., TANAKA M., NAKAJIMA H., NITTA S., SAIJO Y., OHTSUKI S.

    27　(4)　703-703　2000/04/15

    ISSN： 1346-1176

  193. The application of scanning acoustic microscopy to borderline cases of tumor pathology

    SASAKI H., SAIJO Y., TERASAWA Y., OKAWAI H., NITTA S., TANAKA M.

    26　(4)　345-345　1999/04/15

    ISSN： 1346-1176

  194. A case of alveolar proteinosis complicated with pulmonary aspergillosis.

    Nihon Naika Gakkai Kaishi　88　(1)　135-137　1999

    Publisher: The Japanese Society of Internal Medicine

    DOI： 10.2169/naika.88.135 　

    ISSN： 0021-5384

  195. Thickness-distribution Estimation in Tissue Characterization by Using the Acoustic Microscopy

    OGURA Nobuhiko, SAIJO Yoshifumi, TANAKA Naohiko, OHTSUKI Shigeo

    1998　(2)　1165-1166　1998/09/01

    ISSN： 1340-3168

  196. 超音波顕微鏡の生体組織に対する応用 (8月第1土曜特集 バイオイメ-ジング--基礎と臨床の最前線)

    仁田 新一, 西条 芳文

    医学のあゆみ　186　(5)　353-357　1998/08/01

    Publisher: 医歯薬出版

    ISSN： 0039-2359

  197. Analysis of Small Vibration on the Surface of Tissue Exposed to Ultrasound

    SAIJO Y., SATO K., KANAI H., NITTA S., TANAKA M.

    25　(4)　504-504　1998/04/15

    ISSN： 1346-1176

  198. Characterization of Renal Cell carcinoma By Scanning Acoustic Microscopy, Optical Microscopy, and Electron Microscopy

    SASAKI H., SAIJO Y., TERASAWA Y., OKAWAI H., NITTA S., TANAKA M.

    25　(4)　362-362　1998/04/15

    ISSN： 1346-1176

  199. 15)超音波画像の成り立ちの観点による心臓断層像の解釈

    大川井 宏明, 仁田 新一, 山家 智之, 西條 芳文, 佐々木 英彦

    Japanese circulation journal　61　778-778　1998/03/20

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  200. Recent Progress in Artificial Organ Research at Tohoku University

    Tomoyuki Yambe, Makoto Yoshizawa, Akira Tanaka, Ken-ichi Abe, Satoyuki Kawano, Hidetoshi Matsuki, Shigenao Maruyama, Shintaro Amae, Naoshi Wada, Takamichi Kamiyama, Toshiyuki Takagi, Yun Luo, Junko Hayashi, Yuri A.Kovalev, Dan X.D.Sha, Shunsuke Nanka, Yoshifumi Saijo, Yoshiyuki Mibiki, Mune-ichi Shibata, Shin-ichi Nitta

    Art. Organs　27　2-7　1998

    DOI： 10.1046/j.1525-1594.2003.07181.x 　

  201. Explanation of the echo from the oblique surface from a standpoint of echography.

    OKAWAI H., SAIJO Y., YAMBE T., OSAWA H., SASAKI H., SHU L., NITTA K.

    24　(9)　358-358　1997/09/15

    ISSN： 1346-1176

  202. Influence of fat component in the tissue on the high-frequency acoustic properties by scanning acoustic microscopy.

    SASAKI H., SAIJO Y., OKAWAI H., NITTA S., TERASAWA Y., TANAKA M.

    24　(9)　430-430　1997/09/15

    ISSN： 1346-1176

  203. Information entropy of the left ventricular contraction and its clinical significance

    YAMBE T., NANKA S., OKAWAI H., SAIJO Y., NITTA S.

    24　(9)　409-409　1997/09/15

    ISSN： 1346-1176

  204. Sound Speed Measurement of Cultured Cells by Ultrasonic Spectroscopy.

    SAIJO Y., SASAKI H., OKAWAI H., NITTA S., TANAKA M.

    24　(9)　423-423　1997/09/15

    ISSN： 1346-1176

  205. Ultrasonic Properties of Thin Specimens Determined by Acoustic Microscopy.

    SAIJO Y., SASAKI H., OKAWAI H., NITTA S., TANAKA M.

    24　(9)　150-150　1997/09/15

    ISSN： 1346-1176

  206. Visualization of Brain Tissue by Acoustic Microscopy.

    SAIJO Y., HORIMOTO N., SASAKI H., OKAWAI H., NITTA S., TANAKA M.

    24　(9)　167-167　1997/09/15

    Publisher: 東洋出版

    ISSN： 1346-1176

  207. Application of scanning acoustic microscopy to the diseased kidney with renal cell carcinoma

    SASAKI H., SAIJO Y., NITTA S., TERASAWA Y., OKAWAI H., TANAKA M.

    24　(3)　621-621　1997/03/15

    ISSN： 1346-1176

  208. Explanation of the echo from epicardium of posterior wall in the echocardiography

    OKAWAI H., NITTA S., YAMBE T., SAIJO Y., SASAKI H., SHU L.

    24　(3)　474-474　1997/03/15

    ISSN： 1346-1176

  209. Measurement of Thickness of Biological Specimens by Ultrasonic Spectroscopy

    SAIJO Y., SASAKI H., OKAWAI H., NITTA S., TANAKA M.

    24　(3)　562-562　1997/03/15

    ISSN： 1346-1176

  210. Acoustic Properties of the Normal and Pathologic Myocardium by Scanning Acoustic Microscopy

    SAIJO Yoshifumi, SASAKI Hidehiko, OKAWAI Hiroaki, NAGANUMA TORU, TANAKA Motonao

    Jpn J Med Ultrasonics　22　(11)　787-798　1995/11/15

    ISSN： 0287-0592

  211. 27)冠動脈楔入圧の検討(第3報) : 慢性閉塞病変における検討(日本循環器学会第113回東北地方会)

    菊地 雄一, 目黒 泰一郎, 遠藤 閑夫, 大友 達志, 和田 有行, 南家 俊介, 寺沢 良夫, 武田 久尚, 高橋 和彦, 柿沼 義人, 井筒 憲司, 山家 智之, 西條 芳文, 永沼 徹, 小林 信一

    Japanese circulation journal　59　605-605　1995/06/20

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  212. 10)KSエントロピーの計測による左室収縮時系列曲線におけるカオス的ダイナミクスの検出(日本循環器学会第113回東北地方会)

    山家 智之, 仁田 新一, 高橋 和彦, 西條 芳文, 永沼 滋, 小林 信一, 柿沼 義人, 秋保 洋, 南家 俊介, 大沢 上, 永沼 徹, 田中 元直, 福寿 赳雄, 三浦 誠, 内田 直樹, 田林 晄一, 阿部 健一, 吉沢 誠, 高安 秀樹

    Japanese circulation journal　59　603-603　1995/06/20

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  213. 超音波顕微鏡の開発と医学応用

    田中 元直, 西条 芳文

    日本臨床　53　(6)　p1527-1535　1995/06

    Publisher: 日本臨床社

    ISSN： 0047-1852

  214. Acoustic microscopy in medicine and biology. (Proc 2nd Asian Conference on Computer Vision)

    Saijo Yoshifumi, Chubachi Noriyoshi

    Proc 2nd Asian Conference on Computer Vision　3　273-277　1995/04

  215. 0272 補助人工心臓は交感神経活動の情報量エントロピーを低下させる

    山家 智之, 南家 俊介, 小林 信一, 西條 芳文, 仁田 新一

    Japanese circulation journal　59　111-111　1995/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  216. 0316 超音波顕微鏡による動脈硬化病変の定量的評価

    西條 芳文, 佐々木 英彦, 永沼 徹, 田中 元直

    Japanese circulation journal　59　122-122　1995/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  217. MICRO-MEASUREMENTS OF ELASTICITY OF INFARCTED MYOCARDIUM BY A SCANNING ACOUSTIC MICROSCOPE SYSTEM

    SAIJO Yoshifumi, SASAKI Hidehiko, NAGANUMA Toru, TANAKA Motonao

    Japanese circulation journal　57　(7)　656-656　1993/07/20

    Publisher: Japanese Circulation Society

    ISSN： 0047-1828

  218. 左室内における渦流の発生時期とその規模 : 口述発表 : 第57回日本循環器学会学術集会

    田中 元直, 高橋 和彦, 西條 芳文, 密岡 幹夫, 千葉 茂樹, 佐々木 英彦, 仁田 新一

    Japanese circulation journal　57　70-70　1993/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  219. 超音波顕微鏡による心筋梗塞組織弾性率の微小計測 : ポスター発表 : 第57回日本循環器学会学術集会

    西條 芳文, 佐々木 英彦, 永沼 徹, 田中 元直

    Japanese circulation journal　57　203-203　1993/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  220. 左心補助人工心臓駆動下の交感神経活動に関する実験的研究

    山家 智之, 仁田 新一, 片平 美明, 薗部 太郎, 西条 芳文, 秋 保洋, 永沼 滋, 田中 元直

    Japanese circulation journal　56　1035-1035　1992/10/20

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

  221. 流線分布図法による心臓腔内血流動態の解析

    田中 元直, 山本 厚子, 佐藤 ノリ子, 遠藤 閑夫, 高橋 和彦, 西條 芳文, 仁田 新一

    Japanese circulation journal　56　103-103　1992/03/01

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

Show all ︎Show first 5

Books and Other Publications 22

  1. 生体組織の超音波計測

    松川 真美, 山口 匡, 長谷川 英之, ds, 西條 芳文

    コロナ社　2022/05

    ISBN: 9784339013436

  2. 生体ひかりイメージング : 基礎と応用

    星, 詳子, 山田, 幸生eds. 西條 芳文

    エヌ・ティー・エス　2021/12

    ISBN: 9784860437299

  3. Technological advancements in biomedicine for healthcare applications

    Jinglong Wu, ed, Yoshifumi Saijo

    Medical Information Science Reference　2012/10/31

    ISBN: 1466621966

  4. Ultrasonic and electromagnetic NDE for structure and material characterization : engineering and biomedical applications

    Kundu, T, Tribikram) ed Yoshifumi Saijo

    CRC Press　2012/06/25

    ISBN: 1439836639

  5. 非侵襲・可視化技術ハンドブック

    Saijo Yoshifumi

    株式会社エヌティーエス　2007/06

  6. Advanced Ultrasonic Methods for Material Characterization

    Tribikram Kundu, ed. SAIJO Yoshifumi

    ISTE　2007/01

  7. 冠動脈疾患プロフェッション7 冠動脈疾患のNew Concept．

    SAIJO Yoshifumi

    中山書店　2006/07/03

  8. IVUSマニュアル

    SAIJO Yoshifumi

    中山書店　2006/06/30

  9. State of the Art: Ultrasonics in Medicine

    Kouichi Itoh, ed, Saijo Yoshifumi, Tanaka Akira, Sasaki Hidehiko, Iwamoto Takahiro, Santos Filho Esmerald, Yoshizawa Makoto, Yambe Tomoyuki

    Elsevier　2004/04

  10. Vascular Ultrasound（１）

    Saijo Yoshifumi, van der Steen A.F

    Springer　2003/04

  11. Vascular Ultrasound（２）

    Yoshifumi Saijo, A.F.W. van der, Steen ed, Saijo Yoshifumi

    Springer　2003/04

  12. Ultrasonic Methods for Material Characterization

    Dominique Placko, Tribikram Kundu, ed, Saijo Yoshifumi

    Lavosier　2003/04

  13. Ultrasonic Nondestructive Evaluation: Engineering and Biological Material Characterization

    Tribikram Kundu, ed, Saijo Yoshifumi

    CRC Press　2003/04

  14. Acoustical Imaging Vol. 26

    Roman Gr. Maev, ed, Saijo Yoshifumi, Iguchi Atsushi, Tabayashi Koichi, Kobayashi Kazuto, Sasaki Hidehiko, Tanaka Akira, Hozumi Naohiro, Nitta Schin-ichi

    Plenum Publishing Corporations /Kluwer Academic Publishers　2002/04

  15. Acoustical Imaging. Vol. 24

    Hua Lee ed, Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Kataoka Noriyuki, Sato Masaaki, Nitta Schin-ichi, Tanaka Motonao

    Plenum Publishing Corporations /Kluwer Academic Publishers　2000/04

  16. Acoustical Imaging Vol. 23

    Sidney Lees, and Leonard, A. Ferrari, ed, Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Nitta Shin-ichi, Tanaka Motonao

    Plenum Publishing Corporations　1997/04

  17. Ultrasonic Tissue Characterization（２）

    Dunn F Tanaka, M, Ohtsuki S, Saijo Y, ed, Saijo Yoshifumi, Sasaki Hidehiko

    Springer　1996/04

  18. Ultrasonic Tissue Characterization（１）

    Dunn Floyd, Tanaka Motonao, Ohtsuki Shigeo, Saijo Yoshifumi

    Springer　1996/04

  19. Acoustical Imaging Vol. 21

    Joie Pierce Jones, ed, Saijo Yoshifumi, Okawai Hiroaki, Sasaki Hidehiko, Naganuma Toru, Tanaka Motonao

    Plenum Publishing Corporations　1995/04

  20. Acoustical Imaging Vol. 22（２）

    Piero Tortoli, Leonar, Masotti ed, Saijo Yoshifumi, Sasaki Hidehiko, Okawai Hiroaki, Tanaka Motonao

    Plenum Publishing Corporations　1995/04

  21. Acoustical Imaging Vol. 22（１）

    Piero Tortoli, Leonar, Masotti ed, Sasaki Hidehiko, Saijo Yoshifumi, Okawai Hiroaki, Terasawa Yoshio, Nitta Shin-ichi, Tanaka Motonao

    Plenum Publishing Corporations　1995/04

  22. Acoustical Imaging. Vol. 25

    Michael Halliwell, Peter N. T. Wells ed, Saijo Yoshifumi, Jorgensen Claus S, Falk Erling

    Plenum Publishing Corporations /Kluwer Academic Publishers　1995/04

Show all Show first 5

Presentations 70

  1. Main flow axis line deduced from blood flow vector distribution reflects local and whole left ventricular diastolic function. International-presentation

    Nakajima H, Tabuchi H, Sugawara S, Kameyama T, Ohtsuki S, Tanaka M, Saijo Y

    13th Annual Meeting of the European Association of Echocardiography in Cooperation with the Working Group on Echocardiography of the Spanish Society of Cardiology　2009/12/09

  2. Biomedical applications of acoustic microscopy. International-presentation

    2009 IEEE International Ultrasonics Symposium　2009/09/20

  3. Acoustic microscopy – Beyond high resolution imaging. International-presentation

    2009 IEEE International Ultrasonics Symposium　2009/09/20

  4. 高周波超音波イメージング用配向制御圧電結晶膜トランスデューサの開発

    石河睦生, 榮西弘, 長谷川智仁, 森田剛, 西條芳文, 黒澤実, 舟窪浩

    日本音響学会2009年秋季研究発表会　2009/09/15

  5. Visualization of microstructure of the skin by 3D ultrasound microscope. International-presentation

    Saijo Y, Kobayashi K, Hozumi N, Tanaka A

    12th World Congress of the World Federation for Ultrasound in Medicine and Biology　2009/08/30

  6. 流軸線上速度分布による定量的心機能評価法の検討（第二報）

    中島博行, 田中元直, 菅原重生, 片平美明, 亀山剛義, 大槻茂雄, 西條芳文

    日本超音波医学会第82回学術集会　2009/05/24

  7. パラフィン包埋標本作成過程において組織音速に影響を及ぼす因子の検討

    中村陽一, 小林和人, 中村一文, 草野研吾, 穂積直裕, 吉田祥子, 鈴木誠, 西條芳文

    日本超音波医学会第82回学術集会　2009/05/22

  8. 生体組織の固有音響インピーダンスを評価するための簡易計測プローブの提案

    小林和人, 森屋健司, 穂積直裕, 西條芳文

    日本超音波医学会第82回学術集会　2009/05/22

  9. 三次元高周波数超音波イメージングによる皮膚組織の微細構造の観察

    西條芳文, 小林和人, 田中明, 穂積直裕

    日本超音波医学会第82回学術集会　2009/05/22

  10. 低価格携帯型エコー装置の災害時エコノミークラス症候群検診への応用

    西條芳文, 柴田宗一, 榛沢和彦, 小泉勝

    日本超音波医学会第82回学術集会　2009/05/22

  11. 岩手宮城内陸地震における避難環境と深部静脈血栓症（DVT）

    榛沢和彦, 柴田宗一, 西條芳文

    日本超音波医学会第82回学術集会　2009/05/22

  12. 健診での普及を目指したポータブル超音波システムの開発

    西條芳文, 小林和人, 岡田長也, 石黒稔道

    第48回日本生体医工学会大会　2009/04/24

  13. ポータブル超音波システムの健診への応用．

    西條芳文, 小林和人

    第20回日本心エコー図学会学術集会　2009/04/23

  14. 流軸線上速度勾配測定法による左室拡張能評価―Echo-Dynamographyによる解析．

    中島博行, 田中元直, 菅原重生, 片平美明, 亀山剛義, 大槻茂雄, 西條芳文

    第20回日本心エコー図学会学術集会　2009/04/23

  15. Tissue deformation imagingによる心筋収縮dyssynchronyの評価

    西條芳文, 中島博行, 菅原重生, 田淵晴名, 田中明

    第20回日本心エコー図学会学術集会　2009/04/23

  16. コイル状形状記憶合金を応用した消化管蠕動運動アクチュエータの耐久性に関する検討．

    関根一光, 山家智之, 白石泰之, 西條芳文, 佐藤文博, 松木英敏, 前田 剛, 中澤文雄, 淺岡憲三

    第48回日本生体医工学会大会　2009/04/23

  17. 高周波数超音波イメージングによる骨・軟骨複合体組織の観察

    萩原嘉廣, 安藤晃, 西條芳文

    第48回日本生体医工学会大会　2009/04/23

  18. Multimode ultrasound microscope for biomedical applications. International-presentation

    2009 American Institute of Ultrasound in Medicine Annual Convention　2009/04/02

  19. Ultrasonic tissue deformation imaging to evaluate myocardial dyssynchrony.

    Saijo Y, Tanaka A

    日本循環器学会第73回学術集会　2009/03/20

  20. Visualization of micro-vessel by three-dimensional ultrasound microscope.

    Saijo Y, Kobayashi K, Tanaka A

    日本循環器学会第73回学術集会　2009/03/20

  21. Visualization of microvessels in skin by three-dimensional ultrasound microscope. International-presentation

    Saijo Y, Kobayashi K, Hozumi N, Tanaka A, Sakai S

    30th International Symposium on Acoustical Imaging　2009/03/01

  22. High frequency ultrasound imaging of cartilage-bone complex. International-presentation

    Hagiwara Y, Saijo Y, Ando A, Kobayashi K, Tanaka A, Hozumi N, Hatori K, Itoi E

    30th International Symposium on Acoustical Imaging　2009/03/01

  23. The changes of elastic properties of periodontal ligament and mandibular condylar cartilage during development. International-presentation

    Hatori K, Hagiwara Y, Saijo Y, Ando A, Ina Y, Ando K, Shiraishi N, Doi N, Suzuki Y, Sasaki K

    30th International Symposium on Acoustical Imaging　2009/03/01

  24. Biomedical Application of acoustic microscopy - Diagnosis, assessing echogenecity and biomechanics. International-presentation

    Saijo Y, Hagiwara Y, Kobayashi K, Okada N, Tanaka A, Hozumi N, Tanaka M

    IEEE International Ultrasonics Symposium　2008/11/01

  25. Biomedical Application of acoustic microscopy International-presentation

    IEEE International Ultrasonics Symposium　2008/11/01

  26. 音波を用いた血管の組織診断

    第22回日本心血管内視鏡学会　2008/10/11

  27. Visualization of surface and 3D morphology of skin by 100 MHz ultrasound. International-presentation

    Saijo Y

    6th International Conference on Ultrasonic Biomedical Microscanning　2008/09/23

  28. 医学用超音波顕微鏡の現状

    日本音響学会2008年秋季研究発表会　2008/09/10

  29. 血管新生における細動脈イメージング方法の開発

    第56回日本心臓病学会　2008/09/09

  30. High frequency ultrasound imaging of surface and subsurface structures of fingerprints. International-presentation

    Saijo Y, Kobayashi K, Okada N, Hozumi N, Hagiwara Y, Tanaka A, Iwamoto T

    30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society　2008/08/25

  31. High frequency ultrasound characterization of artificial skin. International-presentation

    Iwamoto T, Saijo Y, Hozumi N, Kobayashi K, Okada N, Tanaka A, Yoshizawa M

    30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society　2008/08/25

  32. Recent progress of acoustic microscopy for medicine and biology. International-presentation

    155th Meeting of the Acoustical Society of America integrated with 5th Forum Acusticum of the EAA, 2nd ASA-EAA Joint Conference　2008/06/30

  33. Ultra-mobile echo network in health care system. International-presentation

    Saijo Y, Iwamoto T, Kobayashi K, Yamaguchi S, Tsunoda H, Nakayama H, Kato N, Nemoto Y

    21st IEEE International Symposium on Computer-Based Medical Systems　2008/06/18

  34. 流軸線上速度分布による定量的局所心筋機能評価法の検討－Echo-dynamographyによる流軸線分布図法の応用－

    中島博行, 菅原重生, 片平美明, 田中元直, 亀山剛義, 大槻茂雄, 西條芳文

    日本超音波医学会第81回学術集会　2008/05/25

  35. 高周波数超音波イメージング

    日本超音波医学会第81回学術集会　2008/05/25

  36. Three-dimensional ultrasound imaging of regenerated skin with high frequency ultrasound. International-presentation

    SaijoY, Hagiwara Y, Kobayashi K, Okada N, Hozumi N, Tanaka A, Iwamoto T

    5th IEEE International Symposium on Biomedical Imaging　2008/05/13

  37. 皮膚組織の3次元超音波顕微鏡像

    西條芳文, 萩原嘉廣, 岩本貴宏, 小林和人, 岡田長也, 田中明, 穂積直裕, 富畑賢治

    第47回日本生体医工学会大会　2008/05/10

  38. 脈波伝播速度（PWV）で測る血管の変化

    第47回日本生体医工学会大会　2008/05/10

  39. Visualization of slow flow in left atrium by optical flow method.

    Saijo Y, Tanaka A

    第19回日本心エコー図学会学術集会　2008/04/12

  40. Play Station PortableTM as echo movie client.

    Saijo Y, Iwamoto T, Yoshizawa M

    第19回日本心エコー図学会学術集会　2008/04/12

  41. 等容収縮期の渦流形成に対する心房収縮の関与 －Echodynamographyによる検討－

    中島博行, 菅原重生, 片平美明, 田中元直, 亀山剛義, 大槻茂雄, 西條芳文

    第19回日本心エコー図学会学術集会　2008/04/11

  42. 水熱合成ＰＺＴ多結晶膜による超小型超音波プローブの開発 －超音波イメージングと分解能の検討－

    長谷川智仁, 黒澤実, 石河睦生, 舟窪浩, 竹内真一, 西條芳文

    日本音響学会2009年春季研究発表会　2008/03/19

  43. 超音波ずり弾性率顕微鏡の開発（その2）

    炭親良, 西條芳文

    日本音響学会2009年春季研究発表会　2008/03/19

  44. B-mode and C-mode imaging of regenerated 3D skin model with 100 MHz ultrasound. International-presentation

    Saijo Y, Hagiwara Y, Kobayashi K, Okada N, Tanaka A, Hozumi N, Tomihata K

    2007 IEEE International Ultrasonics Symposium　2007/10/28

  45. Precise calibration for biological acoustic impedance microscope. International-presentation

    Hozumi N, Nakao A, Terauchi S, Nagao M, Yoshida S, Kobayashi K, Yamamoto S, Saijo Y

    2007 IEEE International Ultrasonics Sysmposium　2007/10/28

  46. オプティカルフロー法による心血管内血流の可視化

    西條芳文, 田中明, 田林晄一, 山家智之

    第55回日本心臓病学会　2007/09/11

  47. 生体内超音波ナノ・イメージング法による線維芽細胞の可視化

    西條芳文, 穂積直裕, 小林和人, Santos Filho Esmeraldo

    日本超音波医学会第80回学術集会　2007/05/19

  48. 生体内超音波ナノ・イメージング法の開発

    西條芳文, 穂積直裕, 小林和人, Esmeraldo dos, Santos Filho

    第46回日本生体医工学会大会　2007/04/26

  49. Ultrasonic nano-imaging system for medicine and biology International-presentation

    Yoshifumi Saijo, Naohiro Hozumi, Kazuto Kobayashi, Nagaya Okada, Yoshihiro Hagiwara, Hidehiko Sasaki, Esmeraldo dos, Santos Filho, Tomoyuki Yambe

    29th International Symposium on Acoustical Imaging　2007/04/16

  50. Elastic Changes of Capsule in a Rat Knee Contracture Model Assessed by Scanning Acoustic Microscopy International-presentation

    Yoshihiro Hagiwara, Eiichi Chimoto, Akira Ando, Yoshifumi Saijo, Eiji Itoi

    29th International Symposium on Acoustical Imaging　2007/04/16

  51. Development of Acoustic Impedance Microscope and Its Biological and Medical Applications International-presentation

    Naohiro Hozumi, Satoshi Terauchi, Masayuki Nagao, Sachiko Yoshida, Kazuto Kobayashi, Seiji Yamamoto, Yoshifumi Saijo

    29th International Symposium on Acoustical Imaging　2007/04/16

  52. IVUS Attenuation Imagingによる冠動脈深部の音響特性解析

    藤田雅史, 高山沙織, 塩入裕樹, 小山二郎, 堀口聡, 井上寛一, 田中明, 西條芳文

    第18回日本心エコー図学会　2007/04/12

  53. Two-dimensional Blood Flow Vector in Left Atrium Obtained by Pattern Matching International-presentation

    Yoshifumi Saijo, Akira Tanaka, Yoshikatsu Saiki, Koichi Tabayashi, Tomoyuki Yambe

    International Congress on Ultrasonics 2007　2007/04/09

  54. Ultrasonic Nano-imaging of Living Cells International-presentation

    Yoshifumi Saijo, Kazuto Kobayashi, Naohiro Hozumi, Esmeraldo dos, Santos Filho, Tomoyuki Yambe

    International Congress on Ultrasonics 2007　2007/04/09

  55. Visualization of Vulnerable Plaque by Multiple Parametric IVUS International-presentation

    Yoshifumi Saijo, Akira Tanaka, Esmeraldo dos, Santos Filho, Takahiro Iwamoto, Shuo Li, Tomoyuki Yambe

    International Congress on Ultrasonics 2007　2007/04/09

  56. Tissue sound speed of anterior cruciate ligament in estrogen-controlled rabbits - a measurement using the scanning acoustic microscope International-presentation

    Koshi Hattori, Hirotaka Sano, Yoshifumi Saijo, Eiji Itoi

    International Congress on Ultrasonics 2007　2007/04/09

  57. Coronary plaque classification with intravascular ultrasound radio-frequency signal analysis using self-organizing map International-presentation

    Takahiro Iwamoto, Yoshifumi Saijo, Akira Tanaka, Esmeraldo dos, Santos Filho, Li Shuo, Makoto Yoshizawa

    International Congress on Ultrasonics 2007　2007/04/09

  58. Ultrasonic Tissue Characterization of Thrombus in Coronary Atherosclerosis International-presentation

    Hidehiko Sasaki, Yoshifumi Saijo

    International Congress on Ultrasonics 2007　2007/04/09

  59. Recent Progress of Biomedical Acoustic Microscopy and Multiple Parametric IVUS Imaging at Tohoku University International-presentation

    Yoshifumi Saijo

    Paris-Sendai Symposium on Ultrasonic Tissue Characterization and Small Animal Imaging　2007/04/06

  60. Development of IVUS attenuation imaging and comparison with multiple parametric imagings

    Yoshifumi Saijo, Akira Tanaka, Esmeraldo dos, Santos Filho, Takahiro Iwamoto, Tomoyuki Yambe

    第71回日本循環器学会学術集会　2007/03/15

  61. Two-dimensional blood flow vector imaging of retardant flow in left atrium

    Yoshifumi Saijo, Akira Tanaka, Tomoyuki Yambe

    第71回日本循環器学会学術集会　2007/03/15

  62. Twenty Years’ Development of Acoustic Microscopy for Medicine and Biology. International-presentation

    Saijo Y

    4th joint meeting of the Acoustical Society of America and the Acoustical Society of Japan (152nd Annual Meeting on Acoustical Society of America)　2006/11/27

  63. Multiple Parametric IVUS Imagings for Detection of Vulnerable Plaque International-presentation

    Yoshifumi Saijo, Akira Tanaka, Esmeraldo dos, Santos Filho, Tanahiro Iwamoto, Shuo Li, Makoto Yoshizawa, Tomoyuki Yambe

    9th Sendai Symposium on Ultrasonic Tissue Characterization in Hawaii　2006/11/27

  64. 再生医療の評価方法としての高周波数超音波の可能性

    西條芳文, 白石泰之, 関根一光, 山家智之, 佐野博高, 萩原嘉広, 服部弘之, 田中明, 穂積直裕, 小林和人

    第44回日本人工臓器学会大会　2006/10/31

  65. 3D acoustic microscopy for imaging of liver tissue with 100 MHz ultrasound International-presentation

    Yoshifumi Saijo

    5th Conference on Ultrasonic Biomedical Microscanning　2006/09/11

  66. Evaluation of Cardiac Function of the Patients with Left Ventricular Assist Device by Transesophageal Echocardiography International-presentation

    Saijo Y, Saiki Y, Iguchi A, Tabayashi K, Shiraishi Y, Sekine K, Yambe T

    World Congress on Medical Physics and Biomedical Engineering 2006　2006/08/27

  67. Development of Ultrasonic Nano-imaging System for Visualization of Cells International-presentation

    Saijo Y, Hozumi N, Kobayashi K, Okada N, Lee CK, Sasaki H, Yambe T, Tanaka M

    World Congress on Medical Physics and Biomedical Engineering 2006　2006/08/27

  68. Automated Calcification Detection and Quantification in Intravascular Ultrasound Images by Adaptive Thresholding International-presentation

    Santos Filho E, Saijo Y, Tanaka A, Yambe T, Li S, Yoshizawa M

    World Congress on Medical Physics and Biomedical Engineering 2006　2006/08/27

  69. 超音波による心臓・血管の中の流れの医工学的解析

    西條芳文, 白石泰之, 関根一光, 山家智之, 田中元直, 田林晄一, 早瀬敏幸, 船本健一, 大槻茂雄, 菅原重生

    第43回日本小児外科学会総会　2006/06/07

  70. Automatic segmentation of IVUS image by self-organizing map

    Saijo Y, Tanaka A, Akino Y, Hanadate Y, Yambe T

    日本循環器学会第70回学術集会　2006/03/24

Show all Show first 5

Industrial Property Rights 3

  1. 脳組織変性の診断方法

    高井俊行, 西條芳文, 菅原章子

    Property Type: Patent

  2. 血流可視化診断装置

    早瀬敏幸, 船本健一, 白井敦, 山家智之, 西條芳文

    Property Type: Patent

  3. 超音波診断装置

    西條芳文, 田中明, 坪根泉, 関水英正

    第3720797号

    Property Type: Patent

Research Projects 59

  1. Biomedical imaging Competitive

    1997/07 - Present

  2. Transcranial Whole Brain Imaging by Microwave-induced Thermoacoustics

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. Transcranial Whole Brain Imaging by Microwave-induced Thermoacoustics

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  4. ジラジカル錯体をがん認識光熱変換プローブとするがんの未来型セラノスティクス

    壹岐 伸彦, 西條 芳文, 高橋 透, 唐島田 龍之介, 権田 幸祐

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  5. Development of photoacoustic endoscope using wideband microarray for advanced intraoperative vascularity diagnosis

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    2021/04/05 - 2025/03/31

  6. Ultrasonic signed echo imaging to distinguish bwtween vulnerable and stable plaques

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  7. アーク型光音響トランスデューサーを用いた軟部肉腫反応層の評価

    綿貫 宗則, 西條 芳文, 萩原 嘉廣

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    軟部肉腫は軟部組織に発生する非上皮性悪性腫瘍であり、健常組織とともに腫瘍を摘出する広範切除術が行われる。軟部肉腫と健常組織の境界を見極めることは切除縁を決定するのに重要であるが、手術中に正確に判断するのは難しい。本研究では、ヒト指用に開発されたアーク型光音響トランスデューサーを用い、ラット脂肪組織炎症モデルおよびヒト軟部肉腫周囲の脂肪組織の光音響特性と病理組織所見を比較検討することにより、本装置の妥当性および臨床応用の可能性について検討し、最終的に軟部肉腫の術中切除縁評価が可能な3次元光音響装置開発を目指すものである。 当初の計画ではラットを用いた脂肪組織炎症モデルを作成し、炎症によって変化した脂肪に適したレーザー波長の探索を行う予定であった。しかし、炎症による変化をとらえる波長を探索するよりも、肉腫モデルマウスを作成して、肉腫をとらえるのに適した波長を探索して、それを用いて肉腫の観察を行うほうが合目的と考えられ、当該年度は研究に用いる肉腫株の選定、培養条件の最適化と投与する色素の最適化の探索を行った。また、肉腫モデルマウスは、免疫不全マウスに培養細胞を注射して作成するが、細胞培養株としては骨肉腫細胞株を採用し、継代をしながら安定した培養を行うよう努めている。その骨肉腫細胞が安定して生着するには投与部位や深さ・投与量の調節が必要であり、一定期間で安定して生着できる条件の探索も行っている。

  8. Development of 3D acoustic CT with multi-channel phonocardiogram for lung lesion detection

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2023/03/31

  9. Development of transcranical four-dimensional ultrasound imaging

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  10. Basic study on high-accuracy acoustic property measurements of biological specimens by ultrasonic microscopy

    ARAKAWA Mototaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

    More details Close

    In this study, we proposed a robust analysis method for the acoustic properties of biological specimens measured by acoustic microscopy. To obtain the velocity and thickness of the specimen, parabolic approximation was performed to determine the frequency at which the amplitude of the normalized spectrum became maximum or minimum, considering the sound speed and thickness of the specimens and the operating frequency of the ultrasonic device used. The proposed method was demonstrated for a specimen of malignant melanoma of the skin by using acoustic microscopy attaching a concave transducer with a center frequency of 80 MHz. The variations in sound speed and thickness analyzed by the proposed method were markedly smaller than those analyzed by the method based on an autoregressive model. The proposed method is useful for the analysis of the acoustic properties of biological tissues or cells.

  11. Development of 3D photoacoustic CT with arc tran sducer for finger joint

    Saijo Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Principles of 3D photoacoustic CT were investigated in order to evaluate inflammatory activity of finger joints in rheumatoid arthritis visualized with photoacoustic signal produced by strong short pulsed light. Ultrasonic sensors were semicircularly arranged to fit the shape of finger and optical fibers were inserted to pass through the light. Laser or strong LED with two different wavelengths were illuminated. Precise algorithm for calculation of the oxygen saturation was developed considering the propagation of light in biological tissue. Finally, visualization of the human finger was successfully visualized by the photoacoustic CT.

  12. Cancer theranostics using near-infrared absorbing metal complex as a photothermal probe

    Iki Nobuhiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    We studied functions of a series of Pt(II)-diradical complexes aimed at application to a probe for theranostics of cancer to provide accurate but affordable diagnostics and therapeutic method. The prerequisites of the probe are functions such as near-infrared (NIR) absorption, its switching, photothermal effect, delivery to cancer cells or tumor, stability in cancer cells. We modeled four Pt(II) complexes that can partially fulfill those prerequisites and successfully obtained guidelines for molecular design of a probe for theranostics. This study is a milestone to provide a clear path to obtain the ultimate probe that can meet the requirement of theranostics and to proceed to animal experiment.

  13. Research and developments on next-generation harmonic ultrafast ultrasound imaging for accurate analysis of cardiovascular dynamics

    Hasegawa Hideyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: University of Toyama

    2017/04/01 - 2020/03/31

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    Cardiovascular diseases are the significant causes of mortality in Japan. Methods for the measurement of the cardiovascular dynamics are required to evaluate the cardiovascular function. Particularly, in evaluation of the cardiac function, a high temporal resolution is desirable because the heart is beating rapidly. However, the temporal resolution of a conventional diagnostic ultrasound system is about 30 frames per second (fps), and it is not enough for evaluation of the cardiac function. In the present study, qualitative observation and quantitative evaluation of cardiac blood flow were realized by high-frame-rate ultrasound imaging at a temporal resolution of over 5000 fps. Also, a new ultrasonic array probe using layered piezoelectric elements was investigated for high-contrast ultrasound imaging using harmonic components in ultrasonic echoes.

  14. Innovative theranostics system with magnetic carbon nanotube

    Saijo Yoshifumi, KODAMA Tetsuya, KATO Toshiaki, SIREGAR Syahril

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2017/06/30 - 2019/03/31

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    The basis of innovative theranostics system with magnetic carbon nanotube (M-CNT) was investigated. In the diagnostic side, M-CNT for photoacoustic (PA) imaging was developed and non-local means denoising was applied to reduce PA noise. In the therapeutic side, vibration of M-CNT caused by pulsed magnetic field was confirmed and M-CNT behavior during heating was simulated. The results indicate the application of M-CNT and PA imaging for innovative theranostics system.

  15. Advanced human thermophysiological model for evaluating health risks due to thermal environments

    GOTO TOMONOBU, TAKAKI RIE

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    In order to establish a new human thermophysiological model which can predict not only body temperature but also blood pressure and blood flow rate, we conducted reference data collections through some experiments and field surveys, and developments of the sub-models which compose our new model. In the experiments and field surveys, we obtained detailed physiological data under six steady-state and two unsteady-state conditions, and data on the daily life fluctuations of exposure temperature, blood pressure, etc. in winter. As the sub-model developments, we improved the thermal network and cardiovascular models, and verified their applicability. In addition, we developed a prototype of the physiological model to simulate the regulations of sweat, blood pressure and blood flow rate.

  16. Development of a novel quantitative blood flow sensor for single ventricle disease newborns

    Sai Sadahiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    Despite the recent improvement in the understanding of pathophysiology and the management of the perioperative neonate, the morbidity and mortality rate is not optimal. The aim of this research was to develop a novel, inplantable small sensor to quantify the blood flow both in pulmonary and systemic circulation after Blalock-Taussig shunt operation to improve the perioperative management. Initially, we aimed to explore the way to use polyvinylidene fluoride (PVDF) as a sensor; however, the computer simulation revealed that to obtain enough signal from a small piece of PVDF the huge voltage, which is too danger to yield in the body, would be needed. Therefore, the non-lead seramics was used to develop a sensor, and we successfully manifacutured a 2mm x 2mm size sensor. With those sensors, the flow velocity in a mock circulation made of silicon was capable of being measured by reasonable voltage.

  17. Development of sarcopenia diagnosis device based on 3D-photoacoustic imaging

    Hatori Kouki, Saijo Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Matsumoto Dental University

    2016/04/01 - 2019/03/31

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    Biomedical photoacoustic (PA) imaging system has the unique capability of combining high optical cantrast with high ultrasound (US) resolution in a single modality. When the laser with the wavelength of 532 nm is used, PA signals are reflected from red blood cells. Although the period of the unilateral occlusion induces the chenges of masseter muscle (MM), it is not known that how blood circulation and tissue elasticity of MM are affected by the unilateral occlusion. We aimed to evaluate the sequential changes of MM due to the unilateral occkusion in rats with PA imaging system. PA signals from the MM of the non-occlusal side were significantly lower than that of the occlusalside, and US signals from the MM of the occlusal side were significantly higher than that of non-occlusal side depending on the period of the unilateral occlusion. The PA system can evaluate the blood circulation and the tissue elasticity simultaneously.

  18. Development of photoacoustic flow cytometry by employing multi-channel high frequency ultrasonic probe

    Nagaoka Ryo, SAIJO Yoshifumi, UMEMURA Shin-ichiro, YOSHIZAWA Shin, ARAKAWA Mototaka, ISHIKAWA Kazuo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Category: Grant-in-Aid for Research Activity Start-up

    2016/08/26 - 2018/03/31

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    In a traditional photoacoustic flow cytometry, cells in vessels are aligned in one line by laser manipulation, and the photoacoustic signals induced from the cells are measured to classify the characteristics. However, scattering and absorption in the living tissues has effects on the propagation of the radiated laser, and the alignment of the cell by the manipulation cannot be achieved owing to the effect. In this study, the effect of the scattering and absorption was minimized by acoustical focusing, and the method could visualize the living tissues at the deeper part was developed.

  19. Electromagnetic scanning forward viewing ultrasound endoscope equipped in a guide wire

    Yoichi Haga

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    An electromagnetic scanning forward viewing ultrasound thin endoscope intended to be equipped in a guide wire has been developed for intravascular treatment. The endoscope consists of a resonator with an ultrasonic transducer and a driving coil. Driving of the electromagnetic resonator was confirmed using the driving coil, 50 um witdth silicon beam and a cylindrical shaped samarium cobalt magnet. Almost element technology has been established for fabrication of the device and equipment in the guide wire and ultrasound imaging will be realized by packaging in thin and small size.

  20. Clarification of fluid dynamical effect of near-wall flow field on enrtherial cell damage by measurement-integrated-simulation

    Hayase Toshiyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    It is known that damage on endothelial cells on the surface of a blood vessel causes diseases of blood vessels such as atherosclerosis or aneurisms. However, its mechanism is unknown. This study aimed to clarify the effect of flow field on the endothelial cells’ damage. A complex flow field near the surface of a carotid artery was reconstructed in a flow chamber and experiment of cell peeling by the flow load was conducted. Ultrasonic measurement integrated simulated was also performed to clarify the complex flow field in a carotid artery. Results obtained in this study are expected to be used in developing new diagnostic method of circulatory diseases based on understanding of fluid dynamical effect on cell damages.

  21. Non-invasive visco-elastic imaging for living cells by ultrasound

    Hozumi Naohiro, KOBAYASHI KAZUTO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Toyohashi University of Technology

    2015/04/01 - 2018/03/31

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    In this study, we developed an observatoin system that displays quantitatively and continuously the cultured cells continuously and non-invasively using focused ultrasound, and displays with acoustic impedance that is equivalent to elastic parameter. As the condition of the cytoskeleton highly reflects onto the elasticity of the cell, the degenerative process of the cytoskeleton of the cancer cell after being exposed to anticancer drugs, and the differentiation process of the myoblast calls were observed non-invasively and continuously in live condition. Together with the aim of application to regenerative medicine, we attempted to observe iPS cells.

  22. Atrial natriuretic peptide induces peroxisome proliferator

    Kawamoto Shunsuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Atrial natriuretic peptide is a cardiac atriumderived hormone and its cardioprotective effects have recently been confirmed, but the actual mechanism underlying these effects has not been well elucidated. In this study, we proposed that atrial natriuretic peptide achieves its effects in part via peroxisome proliferator activated receptor c, a nuclear receptor. Atrial natriuretic peptide may achieve its cardioprotective effects in part via the activation of the peroxisome proliferator activated receptor c pathway, particularly in central areas of ischemic lesions.

  23. Intra-operative imaging of soft tissue sarcoma with photoacoustic imaging

    Watanuki Munenori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    Surgery of soft tissue sarcoma is wide resection, which means macroscopically and microscopically complete sarcoma resection with reactive layer and normal tissue around it en bloc. Surgical margin is planned on the basis of pre-operative radiological findings. Under operation, it is quite difficult to confirm boundary between tumor and normal tissue and to judge whether tumor is properly resected. We could make photoacoustic imaging of human osteosarcoma xenograft in athymic nude mice. Photoacoustic imaging may enable intra-operative sarcoma imaging.

  24. Estimation of three-dimensional blood flow vector by super-harmonic echocardiography

    SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04/01 - 2017/03/31

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    A broadband sector ultrasound probe with 64 elements was developed and ultrasound was emitted and received by a programmable ultrasound RF signal processor. Two-dimensional blood flow velocity was deduced by measuring the blood flow vectors from two different viewpoints. The algorithm was validated by a mock blood flow model. Two-dimensional blood flow information on parallel planes were input in three-dimensional equation of continuity and an algorithm for three-dimensional blood flow measurement was developed.

  25. Tomographic imaging of a cell by laser ultrasound microscope with femto-second laser

    SAIJO Yoshifumi, MATSUURA Yuji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    A laser ultrasound microscope with cellular resolution was developed by means of measuring high frequency laser ultrasound signal generated by ultra-short pulsed laser with ZnO thin film sensor. 3T3-L1 cells, which proliferated from fibroblast to adipocyte, were cultured on PET film and observed by the laser ultrasound microscope. C-mode and B-mode images were successfully obtained by the system. The method is capable of measuring sound speed and acoustic impedance and finally visualizes the distribution of Young’s elastic modulus and density within a cell. The method may contribute to the future investigation on cellular biomechanics.

  26. Development of optical fiber probe for all-optic photoacousitc imaging

    Matsuura Yuji, SAIJO YOSHIFUMI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    In this research, optical fiber probes for endoscopic photoacoustic imaging were developed. This probe consists of a bundle of hollow optical fibers delivering excitation laser beams and a single-mode optical fiber with polymer film at the distal end for acoustic detection. A bundle of extremely thin hollow optical fibers was fabricated to improve the resolution and metal coating was applied on the fiber's end to improve the sensitivity for acoustic wave. By using the newly developed probe, photoacoustic images of biomedical samples were successfully obtained.

  27. Development of High-Ouput Ultrasonic Probe for Ultrafast Imaging

    Hasegawa Hideyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    2014/04/01 - 2017/03/31

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    Functional ultrasound imaging is valuable for diagnosis of the circulatory system. Measurement of the tissue dynamics is necessary for functional ultrasound imaging. We have tried to improve the temporal resolution, which is one of the merits of ultrasonography, for accurate measurement of the tissue dynamics. In the present study, an ultrasonic transducer array, to which high input voltage can be applied, was developed for detection of ultrasonic echoes from very weak scatterers, such as blood cells, by increasing the intensity of emitted ultrasound. Also, a multi-channel system for ultrasonic pulse-echo measurement was developed so that high voltages can be applied to the transducer array. Furthermore, we have developed methods for high-contrast ultrasonic imaging and succeeded to visualize weak echoes from blood cells.

  28. Proteomics analysis of frozen shoulder and development of novel therapy and diagnosis

    Hagiwara Yoshihiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2013/04/01 - 2017/03/31

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    Joint stiffness is a very common problem in clinical settings. However, there is no consensus as well as appropriate therapy for it. Frozen shoulder is a common disease with a decrease in range of motion (ROM) and pain resulting in disturbing activity of daily living. We collected samples(ther otator interval coracohumeral ligament, and inferior glenohumeral ligament) from frozen shoulder during arthroscopic pancapsular release. They were analyzed with nanoLC/ESI-MSMS for identification of proteins and each relative expression levels by intensity on each LC-MS data.Besides fibrosis and inflammation, increased adhesion and coagulation cascades may deteriorate pathology of idiopathic frozen shoulder.

  29. Development of noninvasive in vivo hard tissue imaging system using photoacoustic microscope

    Hatori Kouki, SAIJO Yoshifumi, SASAKI Keiichi, HAGIWARA Yoshihiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    Male Wistar rats of 20-week-old (n=5) were used in this study. Mandibles were resected and fixed. Mandibular condylar cartilage was observed with photoacoustic microscopy (PAS). PAS visualized the lesion from subchondral bone to cancellous bone. Ultrasound microscopy visualized the whole cartilage lesion. Thus PAS could visualized the 3-dimentional color image of from cartilage to cancellous bone. Male Wistar rats of 16-week-old (n=5) were used in this study. Right three molars of maxilla were extracted. After 4 weeks of extraction, both masseter muscles were resected and fixed. Masseter muscle was observed with PAS. Photoacoustic signal was lower in extracted side than in non-extracted side. Ultrasound signal was higher in non^extracted side than in non-extracted side.

  30. Photoacoustic molecular imaging of macrophage with metal nanoparticle

    SAIJO YOSHIFUMI, OGASAWARA Koetsu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

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    Acoustical-resolution and optical-resolution photoacoustic microscope system were developed. Photoacoustic properties of some metals was measured and macrophage phagocytosing gold nanorod was observed by the system. Photoacoustic imaging of macrophage with gold nanorod has a potential to be a biomarker of inflammation.

  31. Spatio-temporal analysis of blood flow in bifurcation of blood vessel using ultrasonic-measurement-integrated simulation

    HAYASE Toshiyuki, OBAYASHI Shigeru, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    It has been pointed out that hemodynamics has a strong relationship with occurrence and development of circulatory diseases. However primary parameter to these diseases is still unknown. This research was conducted for a simultaneous analysis of blood pressure (BP) and flow in a carotid artery using photoplethysmography (PPG) and two-dimensional ultrasonic-measurement-integrated (2D-UMI) simulation. The system analyzes BP and flow fields from the viewpoint of influence of phases of BP and flow corresponding to forward and backward waves on vessel wall. The simultaneous analysis system using PPG and 2D-UMI simulation was developed, and characteristics of the blood flow field in a carotid artery was clarified focusing on time variation of the phase corresponding to forward and backward waves identified by wave intensity (WI).

  32. Visco-elastic imaging of biological soft tissues using SP hybrid mode ultrasonic microscope

    HOZUMI Naohiro, TANAKA Naohiko, YOSHIDA Sachiko, YAMAMOTO Seiji, SAIJO Yoshifumi, KOBAYASHI Kazuto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Toyohashi University of Technology

    2012/04/01 - 2015/03/31

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    We have proposed the acoustic microscope for viscoelastic imaging by utilizing both pressure and shear waves focused on the target. The specimen was placed on an acrylic plaque substrate. Pulsed pressure and shear waves with frequency range of 40 - 120 MHz were sequentially produced in the substrate and focused on the top surface of the substrate where the specimen was attached. The shear wave was produced when the pressure wave in water comes into the substrate with oblique incidence. Reflections were interpreted into bulk modulus, shear modulus and viscosity. Mechanical scan made it possible to acquire 2D profiles of these three parameters. A cancerous liver of rat was quantitatively observed. 2D profiles of bulk modulus, shear modulus and viscosity were displayed. Among these three profiles viscosity profile successfully highlighted the cancerous region. A good agreement with optical image was seen after staining with antibody.

  33. A Study on Ultrasonic Measurement and Visualization of Propagation of Myocardial Contraction Response

    KANAI Hiroshi, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

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    For realization of non-invasive regional myocardial tissue characterization, in the present study, we tried to elucidate the characteristic of the myocardial response to the electrical excitation by an in vitro experiment using an excised rat left-ventricular wall. To visualize such propagation phenomenon, whose propagation speed is up to several m/s, high frame rate ultrasound was used. Propagation of the myocardial vibration was visualized by estimating the delay time between vibration waveforms measured in the reference ultrasonic beam and each ultrasonic beam using the cross-correlation function between the vibration waveforms. From the estimated delay time, we visualized the propagation of myocardial vibration caused by the electrical excitation. Propagation velocities were estimated to be 2.5 m/s at the internal and external surfaces of the left-ventricular wall. These results correspond to the results obtained in in vivo experiments measured with high frame rate ultrasound.

  34. Study on visualization of defect of internal elastic lamina of arterial wall for diagnosis of very early-stage atherosclerosis

    KANAI Hiroshi, SAIJO Yoshifumi, HASEGAWA Hideyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2012

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    It would be useful to measure the minute surface roughness of the carotid arterial wall to detect the endothelial damage in the early-stage of atherosclerosis. In conventional ultrasonography, the axial resolution of a B-mode image depends on the ultrasonic wavelength of 150 μm at 10 MHz. Therefore, the surface roughness caused by atherosclerosis in an early stage cannot be measured using a conventional B-mode image obtained by ultrasonography because the roughness is10-20 μm. We have realized accurate transcutaneous estimation of such a minute surface profile using the lateral motion of the carotid arterial wall, which is estimated by block matching of received ultrasonic signals. The proposed method was proved to be able to measure minute surface profile of about 10 μm by measuring a phantom, which had a saw tooth profile on its surface. Furthermore, the surface roughness of the carotid arterial walls of 10-50 μm were measured reproducibly for three healthy subjects (24-, 23-, and 23-year-old males).

  35. Development of Sono-cytometry by High Frequency Ultrasound

    SAIJO Yoshifumi, KANAI Hiroshi, HAYASE Toshiyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2011 - 2012

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    Microfluidic circulation with suspension of micro-molecules was observed by high speed CCD camera. High frequency ultrasound of 120 MHz was emitted to the model and the spectrum of the reflected ultrasound was analyzed by neural network. The dimensions and structures of the micro-molecules were evaluated by the method. Application of the blood flow or lymph flow to the method in living subjects may realize in vivo “sono-cytometry" in the near future.

  36. Smart-ageing Evaluation of Skin by Acoustic Radiation Force Tracked with High Frequency Ultrasound

    SAIJO Yoshifumi, KANAI Hiroshi, HOZUMI Naohiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2010 - 2012

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    Acoustic radiation force (ARF) was applied to the object with 1 MHz ultrasound applicator and the small displacement was measured by phase tracking method of 120 MHz ultrasound. The viscoelastic properties were obtained by analyzing the temporal response of the object to ARF. The efficacy of the method was validated by the measurement of artificial skin with three-layered structure. The method may contribute to smart-ageing evaluation of skin.

  37. Development of Probe System with Super-small Diameter for Intravascular Ultrasound Performing Much Detailed Imaging

    TAGAWA Norio, OKUBO Kan, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tokyo Metropolitan University

    2009 - 2012

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    In this study, we aim to improve the safety and the performance of intravascular ultrasound (IVUS), we proposed a technique to construct an IVUS probe with super-small diameter through the development of the ultra-small ultrasound motor. Additionally, we proposed an actually available ultrasound transmitting/receiving system required for much detailed imaging using the proposed IVUS probe, which is examined from both aspects of hardware and transmitting/receiving schemes. We also developed several signal processing techniques for observed echo signals, and enabled further high quality imaging.

  38. Development of high-resolution 2D-3D hybrid acoustic impedance microscope for biological use

    HOZUMI Naohiro, YOSHIDA Sachiko, YAMAMOTO Seiji, SAIJO Yoshifumi, KOBAYASHI Kazuto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    2009 - 2011

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    We proposed a new ultrasonic microscope for medical and biological use. The target is placed on a plastic substrate, and ultrasonic signal is transmitted and received across the substrate. In this phase of research, we improved spatial resolution, and observed brain tumor model and cultured glioma cells. As for brain tumor tissue, we succeeded in highlighting the tumor by quantifying" local roughness of acoustic impedance". As for cell size observation, we succeeded in observing morphological change of glioma cells after being exposed to anticancer agent. Finally, we succeeded in three dimensional observation of tumor and cultured cells simultaneously with the observation of cross sectional acoustic impedance image.

  39. Vasa Vasorumの可視化を目的とした光音響顕微鏡の開発

    西條 芳文, 松浦 祐司

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 挑戦的萌芽研究

    Category: 挑戦的萌芽研究

    Institution: 東北大学

    2009 - 2010

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    冠動脈の動脈硬化プラークの進展及び破綻に密接に関係するVasa vasorumの臨床的評価方法として、血管内超音波法(IVUS)と同様のシステムで、光と音のハイブリッドにより血管内から外膜側の細動脈を特異的に可視化する血管内光音響イメージングが有効と考えられる。本研究では、ナノ秒パルスレーザーの照射により発生する超音波を受信し、プローブを機械的走査することで反射の三次元分布を可視化する光音響顕微鏡装置を試作することで、1.直径50μmの細動脈が可視化できる解像度が得られること、2.使用するレーザー光の波長により血管や動脈硬化組織に特異的なイメージングが可能であることの2点を明らかにすることを研究目的とした。 平成22年度には、光ファイバーによりレーザー光を集光するという新たなアーキテクチャーにより光音響信号の三次元分布を計測し、分解能50μmについて確認した。さらに、10色のファントムを作成し、532nmのYAG:Ndレーザー光照射により特に赤色ファン等からの光音響信号が強いという分光性について確認した。

  40. Evaluation of Articular Cartilage with High Frequency Ultrasound Imaging System

    HAGIWARA Yoshihiro, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2009 - 2010

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    A newly developed high-frequency ultrasound imaging system (HFUIS) provides noncontact high-resolution 3D ultrasound (US) imaging. A Transducer with central frequency of 120 MHz and a focal length of 3.2 mm was most appropriate for evaluating the articular cartilage. We divided the articular cartilage in three layers (superficial, middle and deep layers) and compare the images with those of scanning acoustic microscope (SAM). A high relative intensity by HFUIS and high sound speed area by SAM had strong correlations (Pearson product moment correlation, superficial layer: 0.704, middle layer: 0.731).

  41. A Study on Noninvasive Ultrasonic Measurement of Minute Mechanical-Excitation Wave-front Propagation in Human Myocardial Tissue and Its Visualization

    KANAI Hiroshi, SAIJO Yoshifumi, HASEGAWA Hideyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2008 - 2010

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    Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3-9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.

  42. Evaluation of Angiogenesis by High Resolution Three-dimensional Ultrasound Molecular Imaging

    SAIJO Yoshifumi, SATO Yasufumi, KODAMA Tetsuya

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2007 - 2009

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    High resolution three-dimensional ultrasound molecular imaging was developed for evaluation of angiogenesis in small animals such as mice. The following were achieved ; 1. Three-dimensional ultrasound imaging system with the frequency range up to 150 MHz and the spatial resolution of 10 micron, 2. Image analysis algorithm for classification of vessels and surrounding tissues by correlation of RF signals in the consecutive frames, 3. Portable scanner for easy and repetitive use, 4. Molecular imaging of angiogenesis with labeled nano-bubble.

  43. Development of a passive-active artificialmyocardium reconcilingthe physiological demands with hemodynamic changes

    SHIRAISHI Yasuyuki, YAMBE Tomoyuki, SAIJO Yoshifumi, UMEZU Mitsuo, FUJIMOTO Tetsuo, BABA Atsushi, TABAYASHI Koichi, HOMMA Dai

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)

    Category: Grant-in-Aid for Young Scientists (A)

    Institution: Tohoku University

    2007 - 2009

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    We developed a sophisticated artificial myocardium which consisted of shape memory alloy fibre units. We applied the PID method for the control of myocardial assist, and examined the dynamic performance as well as hemodynamic changes in goats. It was anticipated that the passive-active artificial myocardium control could be achieved which was reconciling the physiological demands with pathophysiological diagnosis by using our new methodology.

  44. Clinical evaluation of a noninvasive estimation system for cardiac function

    YOSHIZAWA Makoto, NITTA Shinichi, YAMBE Tomoyuki, SAIJO Yoshifumi, TANAKA Akira, SHIRAISHI Yasuyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2006 - 2008

  45. Development of High-speed Microprobe for in vivo Observation of Biological Tissue Using Pulsed Ultrasound

    HOZUMI Naohiro, MASAYUKI Naga, YOSHIFUMI Saijo, YOSHIDA Sachiko, KOBAYASHI Kazuto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Aichi Institute of Technology

    2006 - 2008

  46. 傾斜スケール磁気粒子流体の生体適合化による先進医工学への新展開

    西山 秀哉, 山家 智之, 西條 芳文, 高奈 秀匡

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽研究

    Category: 萌芽研究

    Institution: 東北大学

    2006 - 2007

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    工業用バルブや医療用シール等のMR流体流動システム設計のための基礎資料を提供することを目的として、磁場下にある最新の商用MR流体の詳細なレオロジー特性とオリジナルな可視化実験、圧力流れ場における矩形流路内流動構造の経時変化の実験解析、さらには、矩形流路内流量遮断特性から磁気機能性および流動制御特性を明らかにした。その結果、以下の結論を得た。 1.MR流体の流動曲線や降伏応力の再現性を確認するために、回転粘度計のMR流体試料と接触する回転スピンドルの頂角、円板ギャップ表面粗さによるレオロジー特性への影響を詳細に明らかにした。静的な降伏応力はずり速度が小さい場合、表面粗さがあると滑面に比して大きく、強磁場下でせん断力は平板ギャップが大きいと増加する。これは、棒状クラスター端面と回転スピンドル表面との摩擦力やすべりが影響していると考えられる。 2.圧力流れ場における流路内MR流体シールを破壊するためのピストン移動速度を0.5〜5mm/sに大きく変化させるために、平成18年度に製作したMRシールシステムを試作改良した。 3.磁場下でピストン駆動速度を変化させた場合のMR流体流路の最上流部、シール下端部の圧力の経時変化により、シール形成による流動遮断、シール崩壊および流動、さらには、シール再形成のシナリオをリアルタイムで明らかにした。いずれのピストン駆動速度においても、印加磁場強度の増加と共にシール耐圧が増加し、その増加率は印加磁場強度の二乗にほぼ比例する。また、ピストン駆動速度の増加に対しても、シール耐圧は著しく増加する。これは、ピストン駆動速度の増加に伴い、磁場作用近傍のシール上流部で強磁性微粒子密度が局所的に増加することにより、より強固なクラスターが形成されたためと考えられる。

  47. 極早期段階の動脈硬化診断のための内皮反応性の高感度計測に関する研究

    金井 浩, 西條 芳文, 長谷川 英之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽研究

    Category: 萌芽研究

    Institution: 東北大学

    2006 - 2007

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    本研究では,内皮由来血管弛緩反応に伴って中膜が柔らかくなる現象を,超音波を用いて皮膚から直接計測するための高精度計測法を新たに開発し,内皮の障害も含め,動脈硬化症の無徴候性段階での検出も含めた動脈硬化症の極早期診断法の確立を目指している. 1.1拍内での血管壁の『応力-歪みヒステリシス特性』の評価を可能とする手法とシステムの開発を行った.(1)前年度に開発した連続計測システムを用いて,右腕の血管壁の1拍中での数μmという僅かな厚み変化を80秒間計測した. 同時に左腕の同じ位置で連続計測する血圧波形から,血管壁の1拍での『応力-歪み特性』を算出し,そのヒステリシス特性から動脈壁の弾性特性・粘性特性を評価した.(2)in vivo計測を実施し,駆血解除後の血管反応性に伴い,血管壁(平滑筋からなる内膜・中膜領域)での弾性値・粘性値が,60秒間連続計測できる計測システムを構築した. 2.ヒトの生理的刺激に対する血管内皮機能を評価した.上記のシステムを健常者に適用して血管反応性を評価したところ,血管駆血前の応力-歪みヒステリシス特性に対し,駆血解除直後においてヒステリシスが太くなって粘性が増加し,同時にヒステリシスの傾きが減少して弾性値も減少する現象,その約60秒後には,もとの駆血前の状態に戻る様子が観察された.これは生理学的にも説明ができる結果であり,これらの現象を非侵襲的に世界で初めて計測可能とした成果には大きな意義がある. 3.駆血をせずに血管内皮機能を評価するための方法の新たな開発をするため,自転車漕ぎによって血流を増加させたときの血管壁での内皮由来血管弛緩反応が検出できるかを調べたが,計測対象の微小な厚み変化に比べ,手の動きが大きく,これらの計測の精度を上げることは今後の課題である.

  48. Research on diastolic properties of the myocardium by imaging propagation of shear wave along heart wall

    KANAI Hiroshi, HASEGAWA Hideyuki, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2005 - 2007

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    By ultrasonic measurement of the myocardial motion, we have already found that pulsive waves are spontaneously excited by aortic-valve closure at end-systole. Since myocardial viscoelasticity is essential in the evaluation of heart diastolic properties, this study makes the physiological phenomenon to be measured noninvasively measured in vivo as follows: 1 Using a sparse sector scan, the pulsive waves were measured almost simultaneously at several thousand points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions clearly revealed wave propagation along the heart wall. The phase velocity of the wave is determined for each frequency component. By comparing the dispersion of the phase velocity with the theoretical one of the Lamb wave, which propagates along the viscoelastic plate immersed in blood, the instantaneous viscoelasticity is determined noninvasively. 2 We realized the principle of the measurement in a clinical ultrasonic diagnostic system. 3 By actuating a small pulse in an elastic spherical shell, which was made as a model of the heart, we confirmed that the viscoelasticity of the spherical shell can be measured with an error less than 10% of the viscoelasticity measured by the mechanical test. 4 By applying the developed method to 5 healthy subjects, we confirmed the sufficient reproducibility of the propagation velocity of the pulsive wave among the consecutive cardiac cycles. 5 We confirmed that the difference among the viscoelasticity values estimated from the 5 subjects is less than 20% and the transient of the viscoelasticity just after the aortic valve closure is similar. The viscoelasticity estimates are similar to those measured for the canine heart wall in literature. 6 By applying the method to 10 patients with old myocardial infarction, we found that the amplitude and the propagation speed were decreased in each of the diseased areas. These results correspond to that obtained by using the longitudinal waves in literature. 7 In conclusion, based on the new findings, we developed a means to measure the myocardial viscoelasticity in vivo. These clinical results indicate that the method has a potential for noninvasively revealing myocardial heterogeneity.

  49. 心臓壁内で自発的に生起した高周波パルス状振動の伝搬特性のイメージングに関する研究

    金井 浩, 西條 芳文

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽研究

    Category: 萌芽研究

    Institution: 東北大学

    2004 - 2005

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    本研究の目的は,心臓壁に沿って伝搬するパルス状振動の伝搬状態と伝搬速度を,100Hzまでの周波数帯域でイメージングするための超音波計測方法を確立し,高精度心臓疾患診断の可能性を探究するとともに,数百Hzまでの振動成分による医療診断という新しい研究分野の開拓する.下記の研究を行い,各項目に関して十分な成果を得た. 1.水槽実験によるパルス状振動の伝搬速度の内圧依存性の検討(金井) シリコーンゴムによる弾性球殻を作製し,水槽実験において,パルス状振動が球殻壁上を伝搬する速度を超音波により計測した.ヒトの心臓壁に近い粘弾性特性をもつシリコーンゴムを用いたところ,ほぼヒトの心臓を同じ5m/s程度の伝搬速度が得られた.さらにヒトでは,大動脈弁の閉鎖タイミングにおいて内圧は急激に変化しているため,弾性球殻の内圧を変化させ,球殻を伝搬するパルス状波形の伝搬速度を計測したところ,内圧の低い場合に比較して,内圧を高くした場合に,伝搬速度が速くなる現象が得られた.ヒトに関して得られた結果を裏付けることができた.しかし,1つの波形伝搬中においても伝搬速度に変化があり,これがヒトの場合の伝搬速度の減少に対応する可能性もあることが見出された. 2.伝搬速度の周波数分散の計測とイメージング(金井) 心臓壁内に設定した多数点でほぼ同時に計測されたパルス状振動波形を周波数解析することによって,100Hz成分までの各周波数成分に関する伝搬速度を決定できる計測法を開発し,伝搬速度に大きな速度分散性があることを確認した.これは,心臓の壁の粘弾性によるものであり,心筋の粘弾性を決定できる. 3.心臓疾患患者への適用(西條・金井) 心疾患患者へ適用し,特に心筋梗塞患者の梗塞部位に,このパルス状振動が伝搬しないことを見出した.これは患部の同定にとって非常に重要な知見といえる. 4.本研究の総括(金井) 以上,心筋梗塞による壊死領域の同定などの心臓疾患の診断を非侵襲で高精度に行うことが可能となり,臨床医学的な意義も大きいものと期待できる.

  50. Ultrasonic Nano-imaging of Vascular Endothelial Cell

    SAIJO Yoshifumi, SATO Masaaki, HOZUMI Naohiro, SUZUKI Satoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2003 - 2005

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    For precise imaging of cells, pre-treatments such as antibody sensing are needed in electron scanning microscopy and laser scanning microscopy with fluorescence technique. Non-contact nano-imaging of cells without pre-treatment is anticipated for repeated measurements under various conditions. The objective of the present research is to develop a nano-imaging system that can measure sound speed, attenuation and acoustic impedance of cells with high frequency ultrasound. Further, we compare the distribution of acoustic properties within a cell and cytoskeleton such as actin filaments or tubulin in order to prove the usefulness of the system in the measurement of cellular biomechanics. An electric pulse with the pulse width of 2 ns was generated by high speed mechanical switching was directly input into the ultrasonic transducer. The pulse response was analyzed by a digital oscilloscope. Two servo linear motors controlled by a microcomputer board were used for the scanning in both x- and y-axis of the imaging system. The total system was controlled by a workstation and 300x300 points data acquisition was done within two minutes. The interference between reflections from the surface of the specimen and the interface between the specimen and a glass slide was analyzed in frequency domain. The algorithm for calculation of the thickness and the sound speed of the specimen was established and finally two-dimensional mapping of quantitative sound speed distribution was displayed. Cooling effect of pulmonary vascular endothelial cells was investigated with actin filaments staining, electric impedance measurement and nano-imaging system. The results indicated the usefulness of the system for investigation of cellular biomechanics.

  51. Development of Sound Speed Microscope for Nano-scale Imaging of Biological Tissue Using Pico-second Ultrasonic Pulse

    HOZUMI Naohiro, NAGAO Masayuki, SAIJO Yoshifumi, KOBAYASHI Kazuto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Toyohashi University of Technology

    2003 - 2005

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    Observation of biological tissue by ultrasonic micro-imaging has advantages of being non-destructive and non-contacting, making it possible to quantitatively obtain physical parameters like sound speed and attenuation. We have been developing an ultrasonic sound speed microscope for biological tissues. A thin sliced specimen is placed on a glass substrate, and the reflection of a focused ultrasound pulse with a wide band frequency is interpreted into sound speed and other parameters. A 2D image can be observed when the focal beam spot is mechanically scanned. Its clinical application to histopathological examination during surgery is being considered. The data are also important to assess the origin of clinical echographic imaging. However, the lateral resolution of conventional one used to be as poor as 15 micrometers, although one with a higher resolution was expected to bring important information in biological and medical point of view. In this research project, we aimed to develop an ultrasonic microscope with a resolution of sub-micron level. An ultrasonic microscope using a wide-band pulse spreading from 100-500 MHz was assembled. A piezo-electric stage was employed in order to obtain a resolution of sub-micron level. Cultured nerve cells taken from the hippocampus of a rat was clearly observed as both intensity and sound speed images. In addition, it was clarified that the reflected wave at the interface between the substrate and tissue can be measured when the acoustic wave was transmitted from the rear side of the substrate. Therefore the reflection was visualized as two-dimensional profile of acoustic impedance, in order to observe the tissue without preparing a thin sliced specimen. The structure of the cerebella tissue of a rat was clearly observed as an acoustic impedance image.

  52. An Investigation on Noninvasive Measurement of Transmural Distribution of Myocardial Systolic Function and Diastolic Properties Using Ultrasound

    KANAI Hiroshi, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2003 - 2004

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    For the serious heart diseases, the different transmural layers of the myocardium have transmural heterogeneity with respect to the strength of contraction. A method for measuring such transmural heterogeneity with sufficient spatial resolution has never been developed. In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. Moreover, a novel method for measuring the myocardial viscoelasticity was developed and its principle was confirmed by the basic experiments and in vivo experiments as follows : 1.In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. 2.Based on the basic experiments using a spherical shell made of silicone rubber, which physical parameters are known, as a heart-mimicking phantom, the accuracy of the measurement of the developed method was confirmed. 3.Moreover, this study developed the following novel method for noninvasively measuring the myocardial viscoelasticity at the beginning of diastole and for imaging the transmural heterogeneity in the propagation of the elastic waves. The method was applied to healthy subjects and patients with heart diseases. By this method, a velocity signal of the heart wall can be successfully detected with sufficient reproducibility. In this study, the pulsive waves were measured almost simultaneously at about 160 points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions, obtained by the Fourier transform of the measured waves, clearly revealed wave propagation along the heart wall for the first time. Based on this phenomenon, we developed a means to measure the myocardial viscoelasticity in vivo using the model of the Lamb wave propagation in a viscoelastic plate. This method has a potential to noninvasively evaluate the myocardial viscoelasticity.

  53. Quantitative evaluation of local biomechanics of thoracic aorta

    SAI Sadahiro, TABAYASHI Koichi, SATO Masaaki, SAIJO Yoshifumi, ODA Katsuhiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2003 - 2004

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    The objectives of the present study are to develop a quantitative measurement system of biomechanics of aortic wall by applying ultrasound diagnostics device and to establish an objective indication for rupture of aneurysm and operation. The concrete object of the research during grant-in-aid is to measure the local elasticity of aortic wall by using intravascular ultrasound (IVUS) and transesophageal echocardiography. (TEE) Radio-frequency (RF) signal of clinical IVUS apparatus was sampled via analogue/digital (A/D) converter with sampling rate of 500 MSa/s and stored in a workstation. Electrocardiogram and intracoronary pressure were also sampled via A/D converter with 10 kSa/s, simultaneously. The correlation and displacement of RF lines of the same address in neighboring flames were calculated. Assuming that high correlation area indicated vascular wall, automatic recognition of vascular wall was performed. Tissue velocity was calculated as the difference of the frames was 33 ms. Tissue Velocity Imaging was defined as the tissue velocity in high correlation areas. Short axis view of descending aorta was obtained by a TEE with the central frequency of 4-7 MHz. Electrocardiogram and blood pressure were recorded simultaneously. Two dimensional tissue velocity, vectors were calculated by template matching method of squared region of interests in neighboring frames. IVUS findings and excised specimen by directional coronary atherectomy were compared and TEE findings and surgicaly excised specimen were compared The passive movement by blood pressure variance was correlated with tissue components and expression of inflammatory cells such as macrophages. Finally, precise measurement of biomechanics by applying ultrasonic technology was shown in the present research.

  54. Development of Noninvasive Estimation system of Maximum Ventricular Elastance Emax for Clinical Application

    YOSHIZAWA Makoto, YAMBE Tomoyuki, ABE Kenichi, NITTA Shin-ichi, TANAKA Akira, SAIJO Yoshifumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2002 - 2003

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    The maximum ventricular elastance (Emax) is a good quantitative index for evaluating cardiac pump function. To extensively promote clinical application of Emax, it is necessary to need a new method for obtaining Emax without high invasive measurements. The purpose of this research was to develop a clinical method for estimating Emax low-invasively without any cardiac load on the of the parameter optimization method (POM) and the linear elastance method (LEM) that has been proposed by the authors. Because the POM and LEM need left ventricular pressure (LVP) and aortic flow (AoF), we have also developed a technique to estimate these signals in the following. First, the system we have developed can estimate LVP on the basis of two ARX (autoregressive exogeneous) models : the system model from radial arterial pressure (RdP) to aortic pressure (AoP) and the system model from AoP to LVP, respectively ; In a cardiac catheterization test, these ARX models can be identified by using LVP, AoP and RdP. LVP and AoP are invasive measurements but RdP is measured noninvasively by a tonometric pressure sensor. Once these models are identified, it is guessed that LVP can be estimated fully noninvasively by using RdP even after the previous cardiac catheterization test. Secondly, the developed system can estimate AoF by automatically extracting the contour of Doppler echocardiography during the ejection period. Finally, the total system has been completed in a personal computer unit so as to estimate Emax on the basis of the POM using the off-line data of RdP and the Doppler image of aortic flow rate. An input module has been added to the system to apply the system to real clinical use.

  55. Development of Intravascular Acoustic Microscopy System

    SAIJO Yoshifumi, KANAI Hiroshi, YAMBE Tomoyuki, NITTA Shin-ichi, OKADA Nagaya, OHTSUKI Shigeo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2001 - 2003

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    The cause of acute coronary syndromes such as acute myocardial infarction or unstable angina has been revealed as the rupture of a vulnerable plaque in a coronary artery. The objective of the research project was to develop an intravascular acoustic microscope system applicable to clinical settings. The concrete purpose during the term of Grant-in Aid for Scientific Research was to establish an ultrasonic diagnostic system with 40 MHz frequency which can provide greater information compared with a conventional intravascular ultrasound (IVUS) system. The radio-frequency (RF) signal from a conventional IVUS apparatus was digitized by a high speed A/D converter with a sampling frequency of 500 MSa/s. The ECG and intracoronary pressure were simultaneously digitized and stored in a workstation. Conventional IVUS images and Integrated Backscatter Imaging derived from automatic sensitivity time compensation. RF signals of the same portion in consecutive frames were analyzed and correlation and displacement were calculated. Tissue Velocity Imaging was defined as two-dimensional distribution of the displacement in 1/30 sec where the correlation was 0.7 or more. Tissue Strain Imaging was derived from the tissue velocity difference between two points considering intracoronary pressure change. Normal coronary artery, soft plaque and hard plaque were visualized by the system. The strain of the soft plaque was larger than that of normal coronary artery and the strain was greatly changed during one cardiac cycle. The clinical results suggest the efficiency of the system to assess the pathophysiology of acute coronary syndromes.

  56. Development of a physiologically effective control system for an artificial heart based on autonomic nerve activity

    NITTA Shin-ichi, KONNO Satoshi, SAIJO Yoshifumi, YAMBE Tomoyuki, TANAKA Akira, YOSHIZAWA Makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2000 - 2003

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    In recent years, the application of Ventricular Assist Devices (VAD) has been gradually expanded due to the lack of heart donors and increasing morbidity of cardiovascular diseases. However, there hasn't been an established method for controlling VAD/Total Artificial Heart (TAH) system which can provide physiologically effective circulatory support for a prolonged period of time. Although most investigators adopted an approach to controlling VAD/TAH according to cardiac output or aortic pressure, these conventional methods are not fully reflecting circulatory responses and are reported to occur long-term complications such as thyroid dysfunction or increased central venous pressure. To solve this issue, we newly developed a biocompatible stainless-steel neural interface and successfully recorded autonomic nerve activity of an awake VAD-implanted goat for more than a month. Then we applied fractal dimension analysis, a non-linear analysis method suitable for evaluating complicated biological information, to quantify the changes in autonomic nerve activities. As a result, shifts of the fractal dimension of autonomic nerve activity were observed in response to the changes in circulatory dynamics and posture of animals. Based on the analysis of recorded autonomic nerve activities, a real-time VAD/TAH control system by using fractal analysis-based feedback control algorithm was constructed. Now we attempt to examine the validity of this algorithm and improve it through animal experiments.

  57. Control of Aging by the use of Artificial Organs

    YAMBE Tomoyuki, SAIJO Yoshifumi, NITTA Shin-ichi, YOSHIZAWA Makoto, TABAYASHI Kou-ichi, TANAKA Akira

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku university

    1999 - 2002

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    Since an aging society comes unescapable, we cope with various diseases by the Aging, and have the necessity of aiming at the society where healthy elderly people play an active part. Although an Aging phenomenon can also be considered to be change of the whole body, in the medical spot, it servers as generating of the illness of an internal-organs unit. The illnesses of an internal-organs unit are various medicines and adaptation of a surgical operation. To the internal-organs malfunction which has advanced irreversibl, radical correspondence of transplantation, an artificial organ, etc. becomes indispensable to life maintenance. Therefore, a possibility that support of high-tech medical treatments, such as an articial organ, will become unescapable at the healthy aging society is high. It is becoming old memory with collapse of the Communist bloc that the long-term struggle for existence of the animal experiment of an artificial heart was performed having applied national prestige all over the world. There is an opinion about which it whispered between the artificial heart researchers in the world from that time. It is "aging of the animal after implanting an artificial heart is early ?" It is the hypothesis to say. To pathophysiological change which can be regarded also as promotion of such an Aging after implanting an artificial heart, the syndrome of a "artificial heart syndrome" was proposed in the University of Tokyo. Research on change of the heart blood vessel system in connection with various artificial circulation and Agings has been done even in Tohoku University. The Institute of Development, Aging and Cancer in Tohoku University carried out the research subject "the nonlinear analysis of the artificial heart animal as an Aging promotion model" by the support of the test research from the Ministry of Education science research cost. Cousequently, the artificial heart chronic animal as an Aging promotion model was established. Based on this result, the Ministry of Education, Culture, Sports, Science and Technology science research cost base research "research on control of the Aging phenomenon by chaos control of an artificial organ" was done from 1999 to 2003. Our results suggested the feasibility of control of Aging by the use of the artificial organs.

  58. 低容量超音波による血管内皮細胞への情報伝達

    西條 芳文

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 奨励研究(A)

    Category: 奨励研究(A)

    Institution: 東北大学

    2000 - 2001

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    本研究の目的は、組織に温度上昇やキャビテーションなどによる障害を与えない程度の低容最の超音波を照射し、血管内皮細胞へ情報伝達を行うことが可能かどうかについて検討することである。 直径3cm厚み5mmのPZT平面振動子を直径35mm高さ1cmの円盤状のシャーレ中心に取り付け、インキュベータ中に設置可能なサイズの小型超音波照射装置を作製した。外部の超音波発生装置(ファンクション・ジェネレータ)にて周波数、超音波強度をコントロールし、超音波照射装置に信号を入力した。 ウシ大動脈血管内皮細胞(Bovine Aortic Endothelium Cell:以下BAEC)を使用して実験を行った。35mmのディッシュにDulbecco's Modified Eagle's medium(DMEM)と10%ウシ胎児血清を加え、CO2濃度5%、温度37?に設定されたインキュベータ内にてBAECをconfluentな状態になるまで培養した。BAECをPhosphate Buffered Saline(PBS)で2回洗浄した後、カルシウムイオンに対する蛍光色素であるCa gree-1(2μM)を加えて室温で30分間細胞内に取り込ませた。細胞内に取り込まれなかった蛍光色素を洗浄し、DMEM4mlを加えたものをコントロール群と超音波照射群にわけて観察を行った。超音波照射群に対しては周波数1MHzの微弱超音波をディッシュの下方より照射し、蛍光顕微鏡にて経時的な細胞内カルシウムイオン濃度の変化を3分間にわたって観察した。 超音波照射群では照射開始直後に約10%の一過性の蛍光強度の上昇が観察され、コントロール群ではこのような上昇は観察されなかった。これは微弱超音波がメカニカルな刺激となり、細胞内でのカルシウムイオン濃度を上昇させたためと考えられた。

  59. 高周波数超音波による血管内皮細胞のバイオメカニクスの定量的評価方法の開発

    西條 芳文

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 奨励研究(A)

    Category: 奨励研究(A)

    Institution: 東北大学

    1998 - 1999

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    超音波顕微鏡は高周波数超音波を音響レンズにより集束させ、機械的走査により対象物の音響特性の2次元分布を表示することを基本原理とする。超音波は弾性波としての性質を有するため、音響特性と物理的特性とは密接な関連がある。具体的には超音波の減衰は物質の粘性に、音速は弾性に強く関係しているので、粘弾性体と仮定される細胞のバイオメカニクス計測に対して、超音波顕微鏡は非常に有効な手段となる。 本研究では使用周波数100〜200MHzの超音波顕微鏡により、血管内皮細胞の音響特性を計測した。ウシ大動脈血管内皮細胞(BAEC)に流れによる「ずり応力」を24時間与えたところ、細胞の形態は流れの方向に引き伸ばされた。超音波顕微鏡による音響的計測で、核の音速は1610m/sで不変であったが、細胞質の音速は1570m/sから1590m/sに上昇した。ヒト臍帯静脈血管内皮細胞(HUVEC)にエンドトキシン刺激を与え、前後で超音波顕微鏡によりその形態と音響特性を計測したところ、刺激後には細胞質の減衰は上昇し、その分布は不均一になった。 これらの結果から、血管内皮細胞に対する刺激に対する反応を、超音波顕微鏡にて検出可能であることが証明された。超音波顕微鏡は、細胞に対する蛍光抗体などの前処理が不要で、細胞に非接触で計測でき、将来的にはin vivoにおいても応用可能であるため、細胞のバイオメカニクス計測に有用であることが示された。

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Social Activities 5

  1. Education of Medicine and Biomedical Engineering for Engineers (EMBEE)

    2019/05 - Present

  2. 楽しい理科のはなし

    河北新報

    2012 - Present

  3. [日本国内] 名取市生活習慣病検診

    2007/06/28 - 2007/07/01

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    2次検診および頚動脈エコー検査や携帯電話による積極的介入へのフィールドワーク

  4. [日本国内] 利府町住民講演会

    2006/09/04 -

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    利府町住民に「メタボリックシンドロームと動脈硬化」について講演

  5. [日本国内] 第3回市民のための心臓病講演会

    2006/07/06 -

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    メタボリックシンドロームと高脂血症

Media Coverage 9

  1. 高度救急医療情報伝送

    河北新報

    2009/12/28

    Type: Newspaper, magazine

  2. 高度救急医療伝送

    NHK

    2009/10/07

    Type: TV or radio program

  3. 知的クラスター創生事業報告会

    河北新報

    2009/05/28

    Type: Newspaper, magazine

  4. 知的クラスター創生事業報告会

    NHK

    2009/05/27

    Type: TV or radio program

  5. [日本国内] 冬場の心臓発作

    NHKラジオ第一放送

    2007/11/16

    Type: Other

  6. [日本国内] 三次元超音波顕微鏡

    河北新報

    2007/10/25

    Type: Newspaper, magazine

  7. [日本国内] 三次元超音波顕微鏡

    ミヤギテレビ

    2007/10/25

    Type: TV or radio program

  8. [日本国内] 熱中症について

    NHKラジオ第一放送

    2007/07/20

    Type: Other

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    熱中症とは何か、メカニズム、対策などについて

  9. 超音波画像診断装置の開発

    日本経済新聞

    2007/06/29

    Type: Newspaper, magazine

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Other 6

  1. 超微細超高感度センシングによる疾患の早期発見・兆候検出技術の開発（ウェルネス・センシング）

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    周波数3.5MHzの電子走査型リニアスキャンを用いたポータブル超音波センサのプロトタイプを作製する。 周波数60MHzに対応可能な超高精度機械走査型超音波診断装置を設計し、機械走査部および周波数20MHzの超音波送受信部を作製する。

  2. 三次元複合臓器構造体研究開発

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    最新の材料・生物化学と三次元造型技術、非侵襲評価技術を駆使して、形態的にも機能的にも生態に類似した三次元複合臓器構造体を実現するため、作製過程あるいは移植後生体内での変化が連続モニタリング可能なプロセス評価を実現する非侵襲・低侵襲的評価法を確立することを目的に委託業務を実施する。

  3. 生体内超音波ナノ・イメージング法の開発

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    周波数1.2GHzの超音波を生体組織上で2次元スキャンし、組織表面からの超音波の反射強度の違いを画像化することで、解像度800ナノメートルの生体内超音波ナノ・イメージング方法を開発する。

  4. パルス励起型超音波音速顕微鏡の開発

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    パルス励起型超音波音速顕微鏡の開発

  5. 微弱超音波による血管内皮細胞のNO産生制御

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    微弱超音波による血管内皮細胞のNO産生制御

  6. エンドトキシン刺激に対する血管内皮細胞の形態変化メカニズムの解明 ？超音波顕微鏡による細胞の粘弾性変化の計測？

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    エンドトキシン刺激に対する血管内皮細胞の形態変化メカニズムの解明 ？超音波顕微鏡による細胞の粘弾性変化の計測？

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