Details of the Researcher

PHOTO

Yusuke Takei
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

Research History 13

  • 2018/04 - Present
    東北大学病院 麻酔科 助教

  • 2014/04 - 2018/03
    Tohoku University Graduate School of Medicine

  • 2013/07 - 2014/03
    東北大学病院 麻酔科 助手

  • 2012/04 - 2013/06
    大崎市民病院 麻酔科 医員

  • 2012/01 - 2012/03
    宮城県立こども病院 麻酔科 医員

  • 2011/07 - 2011/12
    東北大学病院 麻酔科 医員

  • 2010/07 - 2011/06
    石巻赤十字病院 麻酔科 医員

  • 2010/02 - 2010/06
    東北大学病院 集中治療部 医員

  • 2009/06 - 2010/01
    仙台赤十字病院 麻酔科 医員

  • 2009/04 - 2009/05
    東北大学病院 麻酔科 医員

  • 2008/10 - 2009/03
    東北厚生年金病院(現. 東北医科薬科大学) 麻酔科 後期研修医

  • 2008/04 - 2008/09
    大崎市民病院 麻酔科 後期研修医

  • 2006/04 - 2008/03
    大崎市民病院 診療部 初期研修医

Show all Show first 5

Education 3

  • 東北大学 大学院 医学系研究科 外科病態学 麻酔科学・周術期医学分野

    2015/04 - 2018/03

  • Tohoku University Faculty of Medicine School of Medicine

    2000/04 - 2006/03

  • 福島県立福島高等学校

    1997/04 - 1999/03

Professional Memberships 5

  • 日本区域麻酔学会

  • JAPAN SOCIETY OF RESPIRATORY CARE MEDICINE

  • 日本心臓血管麻酔学会

  • THE JAPANESE SOCIETY OF INTENSIVE CARE MEDICINE

  • JAPANESE SOCIETY OF ANESTHESIOLOGISTS

Research Interests 3

  • extracellular vesicles

  • acute lung injury

  • sepsis

Research Areas 1

  • Life sciences / Anesthesiology / anesthesia critical care

Papers 51

  1. Brachial Plexus Block Following Serratus Anterior Plane Block After Minimally Invasive Cardiac Surgery Identified Using Contrast X-Ray: A Case Report. International-journal

    Yuna Sato, Michio Kumagai, Yusuke Takei, Kazutomo Saito, Takahiro Tasaki, Masanori Yamauchi

    Case reports in anesthesiology 2026 9755915-9755915 2026

    DOI: 10.1155/cria/9755915  

    More details Close

    A serratus anterior plane block is effective for pain management after minimally invasive cardiac surgery (MICS) but may cause rare complications. In this study, we present a case of upper limb neurological symptoms following a serratus anterior plane block (SAPB) administered after MICS, which was visualized via contrast x-ray imaging. A 74-year-old woman with severe aortic stenosis underwent aortic valve replacement via minithoracotomy. We preoperatively inserted a SAPB catheter deep into the serratus anterior muscle (SAM). Postoperative x-ray imaging with contrast medium revealed its distribution extending from the chest wall (second to fourth ribs), detached from the thorax, toward the right upper arm. We initiated a programmed intermittent bolus infusion (PIBI) via the catheter, but the patient developed reduced grip and sensory deficits in the right arm. Discontinuation of PIBI on postoperative day five led to neurological symptom resolution by day six. The clinical course and contrast distribution suggested that the catheter tip may have migrated to the superficial layer of the SAM. These findings highlight the importance of confirming catheter placement and carefully monitoring neurological symptoms when atypical contrast spread patterns are observed.

  2. Inspiratory effort increases blood volume in the thoracic cavity and decreases end-expiratory lung impedance: a preliminary prospective study. International-journal

    Kazuhiro Takahashi, Ayaka Koyama, Daisuke Irimada, Akihiro Kanaya, Daisuke Konno, Yu Kaiho, Yusuke Takei, Kazutomo Saito, Yutaka Ejima, Masanori Yamauchi

    European journal of applied physiology 2025/04/03

    DOI: 10.1007/s00421-025-05767-5  

    More details Close

    PURPOSE: Passive leg raising (PLR) increases intrathoracic blood volume by redistributing blood from the lower to the upper body area. While inspiratory effort is hypothesized to have a similar effect due to pressure differences between the intrathoracic and extrathoracic cavities, direct evidence is scarce. Therefore, this study evaluated whether excessive inspiratory effort increases intrathoracic blood volume using end-expiratory lung impedance (EELI). METHODS: Volunteers, fitted with electrical impedance tomography (EIT) belts, underwent a spontaneous breathing procedure in the supine position (control step). They breathed through a specialized face mask with separated inspiration and expiration routes (one-way valves) and their EELI was continuously recorded. First, PLR was performed. Subsequently, resistors (3-mm and 2-mm) were sequentially added to the mask's inspiration route, requiring volunteers to increase inspiratory effort. A reference EELI was established during spontaneous breathing, and changes in EELI (ΔEELI) were calculated for each step (control, PLR, 3-mm, and 2-mm). ΔEELI values were compared using the Friedman test and Wilcoxon signed-rank test with Holm's P value adjustment. RESULTS: Across 11 participants, the mean ΔEELI decreased by 13, 18, and 19 units for PLR, 3-mm, and 2-mm resistors, respectively. The Friedman test and Wilcoxon signed-rank test revealed significant differences between the control and each aforementioned intervention. CONCLUSION: PLR and increased inspiratory effort augment thoracic blood volume, thereby reducing EELI. REGISTRATION: UMIN000054238. April/23/2024.

  3. Endothelium-Derived Extracellular Vesicles Expressing Intercellular Adhesion Molecules Reflect Endothelial Permeability and Sepsis Severity. International-journal

    Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Takanori Aihara, Yudai Iwasaki, Toru Murakami, Yu Kaiho, Akira Ohkoshi, Daisuke Konno, Takuya Shiga, Kazuhiro Takahashi, Saori Ikumi, Hiroaki Toyama, Yutaka Ejima, Masanori Yamauchi

    Anesthesia and analgesia 139 (2) 385-396 2024/08/01

    DOI: 10.1213/ANE.0000000000006988  

    More details Close

    BACKGROUND: Currently, clinical indicators for evaluating endothelial permeability in sepsis are unavailable. Endothelium-derived extracellular vesicles (EDEVs) are emerging as biomarkers of endothelial injury. Platelet endothelial cell adhesion molecule (PECAM) and vascular endothelial (VE)-cadherin are constitutively expressed endothelial intercellular adhesion molecules that regulate intercellular adhesion and permeability. Herein, we investigated the possible association between EDEVs expressing intercellular adhesion molecules (PECAM+ or VE-cadherin+ EDEVs) and endothelial permeability and sepsis severity. METHODS: Human umbilical vein endothelial cells (HUVECs) were stimulated with tumor necrosis factor alpha (TNF-α) directly or after pretreatment with permeability-modifying reagents such as angiopoietin-1, prostacyclin, or vascular endothelial growth factor (VEGF) to alter TNF-α-induced endothelial hyperpermeability. Endothelial permeability was measured using the dextran assay or transendothelial electrical resistance. Additionally, a prospective cross-sectional observational study was conducted to analyze circulating EDEV levels in patients with sepsis. EDEVs were examined in HUVEC culture supernatants or patient plasma (nonsepsis, n = 30; sepsis, n = 30; septic shock, n = 42) using flow cytometry. The Wilcoxon rank-sum test was used for comparisons between 2 groups. Comparisons among 3 or more groups were performed using the Steel-Dwass test. Spearman's test was used for correlation analysis. Statistical significance was set at P < .05. RESULTS: TNF-α stimulation of HUVECs significantly increased EDEV release and endothelial permeability. Pretreatment with angiopoietin-1 or prostacyclin suppressed the TNF-α-induced increase in endothelial permeability and inhibited the release of PECAM+ and VE-cadherin+ EDEVs. In contrast, pretreatment with VEGF increased TNF-α-induced endothelial permeability and the release of PECAM+ and VE-cadherin+ EDEVs. However, pretreatment with permeability-modifying reagents did not affect the release of EDEVs expressing inflammatory stimulus-inducible endothelial adhesion molecules such as E-selectin, intracellular adhesion molecule-1, or vascular cell adhesion molecule-1. The number of PECAM+ EDEVs on admission in the septic-shock group (232 [124, 590]/μL) was significantly higher (P = .043) than that in the sepsis group (138 [77,267]/μL), with an average treatment effect of 98/μL (95% confidence interval [CI], 2-270/μL), and the number of VE-cadherin+ EDEVs in the septic-shock group (173 [76,339]/μL) was also significantly higher (P = .004) than that in the sepsis group (81 [42,159]/μL), with an average treatment effect (ATE) of 79/μL (95% CI, 19-171/μL); these EDEV levels remained elevated until day 5. CONCLUSIONS: EDEVs expressing intercellular adhesion molecules (PECAM+ or VE-cadherin+ EDEVs) may reflect increased endothelial permeability and could be valuable diagnostic and prognostic markers for sepsis.

  4. 低侵襲心臓手術後,前鋸筋面ブロックのプログラム間欠投与により一時的な右上肢の神経症状を呈した一症例

    田崎 貴大, 佐藤 友菜, 熊谷 道雄, 岩崎 夢大, 太田 卓尚, 武井 祐介

    Cardiovascular Anesthesia 27 (Suppl.) 204-204 2023/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  5. 超長時間大動脈遮断症例の補助循環の使用状況とその予後についての検討

    尾形 優子, 吉田 亜古, 佐藤 友菜, 熊谷 道雄, 鈴木 真奈美, 武井 祐介

    Cardiovascular Anesthesia 27 (Suppl.) 249-249 2023/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  6. Accuracy of Cardiac Output Measured by Fourth-Generation FloTrac and LiDCOrapid, and Their Characteristics Regarding Systemic Vascular Resistance in Patients Undergoing Cardiac Surgery. International-journal

    Yusuke Takei, Michio Kumagai, Manami Suzuki, Sakura Mori, Yuna Sato, Toru Tamii, Akane Tamii, Ako Saito, Yuko Ogata, Yu Kaiho, Hiroaki Toyama, Yutaka Ejima, Masanori Yamauchi

    Journal of cardiothoracic and vascular anesthesia 37 (7) 1143-1151 2023/07

    DOI: 10.1053/j.jvca.2023.03.019  

    More details Close

    OBJECTIVES: The clinical use of less-invasive devices that calculate the cardiac output from arterial pressure waveform is increasing. The authors aimed to evaluate the accuracy and characteristics of the systemic vascular resistance index (SVRI) of the cardiac index measured by 2 less-invasive devices, fourth-generation FloTrac (CIFT) and LiDCOrapid (CILR), compared with the intermittent thermodilution technique, using a pulmonary artery catheter (CITD). DESIGN: This was a prospective observational study. SETTING: This study was conducted at a single university hospital. PARTICIPANTS: Twenty-nine adult patients undergoing elective cardiac surgery. INTERVENTIONS: Elective cardiac surgery was used as an intervention. MEASUREMENTS AND MAIN RESULTS: Hemodynamic parameters, CIFT, CILR, and CITD, were measured after the induction of general anesthesia, at the start of cardiopulmonary bypass, after completion of weaning from cardiopulmonary bypass, 30 minutes after weaning, and at sternal closure (135 measurements in total). The CIFT and CILR had moderate correlations with CITD (r = 0.62 and 0.58, respectively). Compared with CITD, CIFT, and CILR had a bias of -0.73 and -0.61 L/min/m2, limit of agreement of -2.14-to-0.68 L/min/m2 and -2.42-to-1.20 L/min/m2, and percentage error of 39.9% and 51.2%, respectively. Subgroup analysis for evaluating SVRI characteristics showed that the percentage errors of CIFT and CILR were 33.9% and 54.5% in low SVRI (<1,200 dyne×s/cm5/m), 37.6% and 47.9% in moderate SVRI (1,200-1,800 dyne×s/cm5/m), 49.3% and 50.6% in high SVRI (>1,800 dyne·s/cm5/m2), respectively. CONCLUSIONS: The accuracy of CIFT or CILR was not clinically acceptable for cardiac surgery. Fourth-generation FloTrac was unreliable in high SVRI. LiDCOrapid was inaccurate across a broad range of SVRI, and minimally affected by SVRI.

  7. 細胞外小胞に着目した人工呼吸関連肺傷害の内皮傷害マーカーの探索

    武井 祐介, 岩崎 夢大, 紺野 大輔, 入間田 大介, 関根 智宏, 齋藤 秀悠, 杉野 繁一, 鈴木 潤, 山内 正憲

    日本集中治療医学会雑誌 30 (Suppl.1) S579-S579 2023/06

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  8. 細胞外小胞に着目した人工呼吸関連肺傷害の内皮傷害マーカーの探索

    武井 祐介, 岩崎 夢大, 紺野 大輔, 入間田 大介, 関根 智宏, 齋藤 秀悠, 杉野 繁一, 鈴木 潤, 山内 正憲

    日本集中治療医学会雑誌 30 (Suppl.1) S579-S579 2023/06

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  9. Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. International-journal

    Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

    Journal of clinical medicine 12 (10) 2023/05/14

    DOI: 10.3390/jcm12103460  

    More details Close

    Coronavirus disease 2019 (COVID-19) is associated with coagulopathy. However, the underlying mechanisms are not completely understood. We evaluated the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. We hypothesized that several EV levels would be higher in COVID-19 coagulopathy patients than in non-coagulopathy patients. This prospective observational study was conducted in four tertiary care faculties in Japan. We enrolled 99 COVID-19 patients (48 with coagulopathy and 51 without coagulopathy) aged ≥20 years who required hospitalization, and 10 healthy volunteers; we divided the patients into coagulopathy and non-coagulopathy groups according to the D-dimer levels (≥1 μg/mL and <1 μg/mL, respectively). We used flow cytometry to measure the tissue-factor-bearing, endothelium-derived, platelet-derived, monocyte-derived, and neutrophil-derived EV levels in platelet-free plasma. The EV levels were compared between the two COVID-19 groups as well as among the coagulopathy patients, non-coagulopathy patients, and healthy volunteers. No significant difference was found in EV levels between the two groups. Meanwhile, the cluster of differentiation (CD) 41 + EV levels were significantly higher in COVID-19 coagulopathy patients than in healthy volunteers (549.90 [255.05-984.65] vs. 184.3 [150.1-254.1] counts/µL, p = 0.011). Therefore, CD41+ EVs might play an essential role in COVID-19 coagulopathy development.

  10. 【先天性心疾患治療の発展】成人先天性心疾患の非心臓手術麻酔管理

    外山 裕章, 齊藤 和智, 武井 祐介, 高橋 和博, 江島 豊, 山内 正憲

    循環制御 43 (2) 60-63 2022/12

    Publisher: 日本循環制御医学会

    ISSN: 0389-1844

  11. 呼吸器外科手術の周術期管理 呼吸器外科手術の術前評価と管理

    外山 裕章, 高橋 和博, 海法 悠, 齊藤 和智, 武井 祐介, 江島 豊

    日本臨床麻酔学会誌 42 (7) 622-629 2022/11

    Publisher: 日本臨床麻酔学会

    ISSN: 0285-4945

    eISSN: 1349-9149

  12. 呼吸器外科手術の周術期管理 呼吸器外科手術の術前評価と管理

    外山 裕章, 高橋 和博, 海法 悠, 齊藤 和智, 武井 祐介, 江島 豊

    日本臨床麻酔学会誌 42 (7) 622-629 2022/11

    Publisher: 日本臨床麻酔学会

    ISSN: 0285-4945

    eISSN: 1349-9149

  13. 肺動脈カテーテルによる肺動脈損傷と大量喀血をきたした急性大動脈解離の一例

    海法 悠, 岩崎 夢大, 関根 智宏, 宇賀神 咲久絡, 佐藤 友菜, 民井 あかね, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 26 (Suppl.) 213-213 2022/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  14. Worsening Right Ventricular Function During Cardiac Surgery Is a Strong Predictor of Postoperative Acute Kidney Injury: A Prospective Observational Study.

    Yasuaki Tohi, Yusuke Takei, Kotaro Nochioka, Hiroaki Toyama, Masanori Yamauchi

    The Tohoku journal of experimental medicine 258 (2) 129-141 2022/08/04

    DOI: 10.1620/tjem.2022.J064  

    More details Close

    This prospective, observational study was conducted in a university hospital to verify that intraoperative worsening of right ventricular function causes cardiac surgery-associated acute kidney injury. Adult patients undergoing cardiac surgery under mid-sternal incision with cardiopulmonary bypass were included. Echocardiographic right and left ventricular function parameters were measured before and after bypass and compared using the Wilcoxon signed-rank test. Perioperative serum creatinine values at baseline and within the first 48 hours postoperatively were measured for the diagnosis of acute kidney injury. Spearman rank-order correlation (ρ) and receiver operating characteristic analysis were used to reveal relationships. Thirty-four patients were evaluated. Right ventricular ejection fraction (56.2 ± 7.0 vs. 51.6 ± 7.2%; P = 0.0002), right ventricular fractional area change (49.1 ± 6.4 vs. 46.6 ± 5.3%; P = 0.0201; mean ± standard deviation), and left ventricular ejection fraction (57.4 ± 6.1 vs. 51.7 ± 6.2%; P < 0.0001) were significantly decreased. Central venous pressure was significantly increased (7.2 ± 3.5 vs. 9.7 ± 3.7; P = 0.0001). Serum creatinine values increased from 0.82 [0.70-1.08] to 0.99 [0.82-1.54] mg/dL (P < 0.0001; median [interquartile range]). Changes in right ventricular ejection fraction, fractional area change, and right ventricular strain during cardiovascular surgery were significantly correlated with changes in serum creatinine values. Fractional area change exhibited the strongest correlation (ρ = -0.61, P < 0.0001). Change in fractional area change showed an area under the curve of 0.902 and a cutoff value of -2.1, which predicted acute kidney injury with 92% sensitivity, 73% specificity, and 79% accuracy. The functions of both ventricles were decreased after cardiopulmonary bypass. Worsening right ventricular function was independently correlated with postoperative renal dysfunction, and fractional area change was the strongest predictor of cardiac surgery-associated acute kidney injury.

  15. 【成人先天性心疾患(ACHD)診療の現状と展望】非心臓手術の麻酔管理

    外山 裕章, 齋藤 和智, 武井 祐介, 高橋 和博, 江島 豊, 山内 正憲

    循環器内科 91 (1) 27-33 2022/01

    Publisher: (有)科学評論社

    ISSN: 1884-2909

  16. ECMOの多様な用途と合併症回避の工夫 ECMO患者の凝固障害の管理とCOVID-19での注意点

    岩崎 夢大, 武井 祐介

    循環制御 42 (2) 77-80 2021/12

    Publisher: 日本循環制御医学会

    ISSN: 0389-1844

  17. Venovenous Extracorporeal Membrane Oxygenation During Bilateral Lung Transplantation for a Patient With Eisenmenger Syndrome Complicated With Giant Pulmonary Artery Aneurysm, Azygos Continuation, and Central Airway Obstruction. International-journal

    Hiroaki Toyama, Yusuke Takei, Kazutomo Saito, Kazuhiro Takahashi, Tomoyuki Suzuki, Hisashi Oishi, Yoshikatsu Saiki, Yoshinori Okada, Yutaka Ejima, Masanori Yamauchi

    Journal of cardiothoracic and vascular anesthesia 36 (8 Pt B) 3132-3138 2021/11/11

    DOI: 10.1053/j.jvca.2021.11.008  

  18. Effects of oxytocin on responses to nociceptive and non-nociceptive stimulation in the upper central nervous system. International-journal

    Hidehisa Saito, Shizu Hidema, Ayano Otsuka, Jun Suzuki, Michio Kumagai, Akihiro Kanaya, Toru Murakami, Yusuke Takei, Kazutomo Saito, Shigekazu Sugino, Hiroaki Toyama, Ryuta Saito, Teiji Tominaga, Katsuhiko Nishimori, Masanori Yamauchi

    Biochemical and biophysical research communications 574 8-13 2021/10/15

    DOI: 10.1016/j.bbrc.2021.08.042  

    More details Close

    Oxytocin is known as a social bonding hormone, but it also functions as an anxiolytic or analgesic neurotransmitter. When oxytocin regulates pain or anxiousness centrally as a neurotransmitter, it is secreted by neurons and directly projected to targeted regions. Although the function of oxytocin at the spinal level is well studied, its effects at the supraspinal level are poorly understood. We aimed to investigate the effect of oxytocin at the supraspinal level in vivo using C57BL/6J (wild-type [WT]), oxytocin-deficient (Oxt-/-), oxytocin receptor-deficient (Oxtr-/-), and oxytocin receptor-Venus (OxtrVenus/+) mice lines. Response thresholds in Oxtr-/- mice in Hargreaves and von-Frey tests were significantly lower than those in WT mice, whereas open field and light/dark tests showed no significant differences. Moreover, response thresholds in Oxt-/- mice were raised to those in WT mice after oxytocin administration. Following the Hargreaves test, we observed the co-localisation of c-fos with Venus or the oxytocin receptor in the periaqueductal gray (PAG), medial amygdala (MeA), and nucleus accumbens (NAc) regions in OxtrVenus/+ mice. Furthermore, in the PAG, MeA, and NAc regions, the co-localisation of oxytocin with c-fos and gamma-aminobutyric acid was much stronger in Oxtr-/- mice than in WT mice. However, following von-Frey test, the same findings were observed only in the MeA and NAc regions. Our results suggest that oxytocin exerts its analgesic effect on painful stimulation via the PAG region and a self-protective effect on unpleasant stimulation via the MeA and NAc regions.

  19. 長時間大動脈遮断症例の人工心肺離脱方法と合併症の後ろ向き検討

    吉田 亜古, 外山 裕章, 熊谷 道雄, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 25 (1) 29-35 2021/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  20. 長時間大動脈遮断症例の人工心肺離脱方法と合併症の後ろ向き検討

    吉田 亜古, 外山 裕章, 熊谷 道雄, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 25 (1) 29-35 2021/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  21. 症例カンファレンス 左室流出路狭窄患者の大腿骨転子部骨折手術

    澤田 憲一郎, 小坂 順子, 武井 祐介, 外山 裕章, 宮本 美希

    LiSA 28 (6) 557-573 2021/06

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN: 1340-8836

    eISSN: 1883-5511

  22. 症例カンファレンス 左室流出路狭窄患者の大腿骨転子部骨折手術

    澤田 憲一郎, 小坂 順子, 武井 祐介, 外山 裕章, 宮本 美希

    LiSA 28 (6) 557-573 2021/06

    Publisher: (株)メディカル・サイエンス・インターナショナル

    ISSN: 1340-8836

    eISSN: 1883-5511

  23. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大塲 瑠璃, 亀山 良亘, 志賀 卓弥, 金谷 明浩, 武井 祐介, 齋藤 浩二, 山内 正憲

    日本集中治療医学会雑誌 28 (3) 222-223 2021/05

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

    More details Close

    40歳代女性。25年前に気管支拡張症と診断され、慢性呼吸不全の状態であった。今回、両肺移植術を施行され、術後ICUに入室した。入室8日目に抜管したが、喀痰排出困難のため再挿管し、9日目に気管切開術を施行した。術後に気管切開部と胸腔ドレーン刺入部の痛みを訴え、鎮痛薬の全身投与を行ったが、体動時痛が強く、清拭やリハビリテーションの継続が困難であった。気管切開部痛に対して浅頸神経叢ブロックを行い、胸腔ドレーン刺入部痛に対して肋間神経ブロックを行ったところ体動時痛は軽減し、リハビリテーションの実施が可能となった。

  24. 絞扼性イレウスの重症度と術前プロカルシトニン値の関係

    角田 博, 武井 祐介, 杉野 繁一, 山内 正憲

    Shock: 日本Shock学会雑誌 35 (1) 53-53 2021/05

    Publisher: (一社)日本Shock学会

    ISSN: 0919-8156

    eISSN: 2185-8225

  25. 肺高血圧症患者のリバースリモデリング 両肺移植前後の心室容積変化

    土肥 泰明, 外山 裕章, 武井 祐介, 江島 豊, 山内 正憲

    日本循環制御医学会総会プログラム・抄録集 41回 41-41 2021/02

    Publisher: 日本循環制御医学会

  26. 開心術における人工心肺後の右室機能に関する検討

    土肥 泰明, 武井 祐介, 民井 亨, 佐藤 友菜, 海法 悠, 森 咲久絡, 山内 正憲

    Cardiovascular Anesthesia 24 (Suppl.) 105-105 2020/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  27. 体外式膜型人工肺と補助循環用ポンプカテーテルを併用して急性期管理を行った心室中隔穿孔の一例

    尾形 優子, 武井 祐介, 宇井 あかね, 舟橋 優太郎, 佐藤 友菜, 民井 亨, 山内 正憲

    Cardiovascular Anesthesia 24 (Suppl.) 128-128 2020/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  28. 人工心肺終了後に急速に上大静脈症候群を来した一症例

    室井 賢一, 高橋 菜々子, 武井 祐介, 高橋 和博, 早川 聖子, 大山 萌

    Cardiovascular Anesthesia 24 (Suppl.) 167-167 2020/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  29. 多発肋骨骨折によるフレイルチェストの疼痛管理に前鋸筋-肋間筋面ブロックを施行した一例

    渡辺 千晶, 亀山 良亘, 舟橋 優太郎, 民井 あかね, 武井 祐介, 齊藤 和智, 志賀 卓也, 齋藤 浩二, 江島 豊, 山内 正憲

    日本集中治療医学会雑誌 27 (Suppl.) 578-578 2020/09

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  30. Increase in circulating ACE-positive endothelial microparticles during acute lung injury. International-journal Peer-reviewed

    Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Hisatoshi Sugiura, Tomonori Makiguchi, Naoya Fujino, Akira Koarai, Hiroaki Toyama, Kazutomo Saito, Yutaka Ejima, Yu Kawazoe, Daisuke Kudo, Shigeki Kushimoto, Masanori Yamauchi, Masakazu Ichinose

    The European respiratory journal 54 (4) 2019/10

    DOI: 10.1183/13993003.01188-2018  

    ISSN: 0903-1936

    eISSN: 1399-3003

  31. 成人右室二腔症の麻酔経験 Peer-reviewed

    森 咲久絡, 武井 祐介, 舟橋 優太郎, 熊谷 道雄, 鈴木 真奈美, 江島 豊

    Cardiovascular Anesthesia 23 (Suppl.) [DP1-09] 2019/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  32. Hemodynamic Failure Caused by Adrenaline Administration for Anaphylaxis Reaction in a Patient at Risk for Systolic Anterior Motion of Mitral Valve (SAM)

    則内梓, 齊藤和智, 外山裕章, 江島豊, 武井祐介, 吉田亜古, 山内正憲

    麻酔 67 (2) 157‐161 2018/02/10

    ISSN: 0021-4892

  33. Influences of environmental noise level and respiration rate on the accuracy of acoustic respiration rate monitoring. International-journal Peer-reviewed

    Shizuha Yabuki, Hiroaki Toyama, Yusuke Takei, Toshihiro Wagatsuma, Hiroshi Yabuki, Masanori Yamauchi

    Journal of clinical monitoring and computing 32 (1) 127-132 2018/02

    DOI: 10.1007/s10877-017-9997-y  

    ISSN: 1573-2614 1387-1307

  34. Ventricular Assist Device Implantation in a Patient With Severe Systemic Right Ventricular Failure and Pulmonary Hypertension Secondary to Congenitally Corrected Transposition of Great Arteries Peer-reviewed

    Hiroaki Toyama, Yusuke Takei, Kazutomo Saito, Sakura Mori, Akane Ui, Naoya Kobayashi, Shunsuke Tatebe, Osamu Adachi, Yutaka Ejima, Masanori Yamauchi

    Journal of Cardiothoracic and Vascular Anesthesia 32 (1) 436-440 2018/02/01

    DOI: 10.1053/j.jvca.2017.04.007  

    ISSN: 1532-8422 1053-0770

  35. A successful case of pediatric acute fulminant myocarditis with recovery using fast induction of central extracorporeal membrane oxygenation Peer-reviewed

    Kanaya Akihiro, Kameyama Yoshinobu, Takei Yusuke, Shiga Takuya, Wagatsuma Toshihiro, Ejima Yutaka, Saito Koji, Yamauchi Masanori

    Journal of the Japanese Society of Intensive Care Medicne 25 (3) 197-198 2018

    Publisher: 一般社団法人 日本集中治療医学会

    DOI: 10.3918/jsicm.25_197  

    ISSN: 1340-7988

  36. A successful case of pediatric acute fulminant myocarditis with recovery using fast induction of central extracorporeal membrane oxygenation

    金谷明浩, 亀山良亘, 武井祐介, 志賀卓弥, 吾妻俊弘, 江島豊, 齋藤浩二, 山内正憲

    日本集中治療医学会雑誌(Web) 25 (3) 197‐198(J‐STAGE)-198 2018

    Publisher: 一般社団法人 日本集中治療医学会

    DOI: 10.3918/jsicm.25_197  

    ISSN: 1882-966X

  37. Positive pressure ventilation in a patient with a right upper lobar bronchocutaneous fistula: right upper bronchus occlusion using the cuff of a left-sided double lumen endobronchial tube. Peer-reviewed

    Chieko Omori, Hiroaki Toyama, Yusuke Takei, Yutaka Ejima, Masanori Yamauchi

    Journal of anesthesia 31 (4) 627-630 2017/08

    DOI: 10.1007/s00540-017-2336-0  

    ISSN: 0913-8668

    eISSN: 1438-8359

  38. Anesthetic management for scoliosis surgery with double‐switch operation for congenitally corrected transposition of the great arteries

    阿部望, 外山裕章, 太田卓尚, 武井祐介, 齊藤和智, 戸田法子, 川名信, 山内正憲

    日本小児麻酔学会誌 22 (1) 241-244 2016/09

    Publisher:

    ISSN: 1341-5603

  39. Management of three cardiogenic pulmonary edemas occurring in a patient scheduled for left ventricular assist device implantation: indicators for determining left ventricular assist device pump speed. Peer-reviewed

    Hiroaki Toyama, Yusuke Takei, Kazutomo Saito, Takahisa Ota, Kenji Kurotaki, Yutaka Ejima, Takeshi Matsuura, Masatoshi Akiyama, Yoshikatsu Saiki, Masanori Yamauchi

    Journal of anesthesia 30 (4) 711-5 2016/08

    DOI: 10.1007/s00540-016-2163-8  

    ISSN: 0913-8668

    eISSN: 1438-8359

  40. A case of a giant cell myocarditis that developed massive left ventricular thrombus during percutaneous cardiopulmonary support. International-journal Peer-reviewed

    Yusuke Takei, Yutaka Ejima, Hiroaki Toyama, Kana Takei, Takahisa Ota, Masanori Yamauchi

    JA clinical reports 2 (1) 41-41 2016

    DOI: 10.1186/s40981-016-0067-0  

    ISSN: 2363-9024

  41. Perioperative management of esophagectomy in a patient who previously underwent bilateral lung transplantation. International-journal Peer-reviewed

    Hiroaki Toyama, Kazutomo Saito, Yusuke Takei, Kana Saito, Takuya Fujimine, Yutaka Ejima, Takashi Kamei, Tatsuaki Watanabe, Yoshinori Okada, Masanori Yamauchi

    JA clinical reports 2 (1) 15-15 2016

    DOI: 10.1186/s40981-016-0041-x  

    ISSN: 2363-9024

  42. Two cases of bilateral lung transplantation combined with intracardiac repair and pulmonary artery replacement: perioperative managements based on the left ventricular function. Peer-reviewed

    Hiroaki Toyama, Kazutomo Saitoh, Yusuke Takei, Yutaka Ejima, Shin Kurosawa, Masanori Yamauchi

    Journal of anesthesia 29 (6) 957-61 2015/12

    DOI: 10.1007/s00540-015-2043-7  

    ISSN: 0913-8668

    eISSN: 1438-8359

  43. 周術期管理 麻薬による呼吸抑制(RRモニター)

    武井祐介, 星邦彦, 山内正憲

    救急・集中治療 27 (5-6) 489-496 2015/06/16

    ISSN: 1346-0935

  44. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. International-journal Peer-reviewed

    Chiharu Ota, Mitsuhiro Yamada, Naoya Fujino, Hozumi Motohashi, Yukiko Tando, Yusuke Takei, Takaya Suzuki, Toru Takahashi, Satoshi Kamata, Tomonori Makiguchi, Mutsuo Yamaya, Hiroshi Kubo

    Experimental lung research 41 (8) 422-34 2015

    DOI: 10.3109/01902148.2015.1060275  

    ISSN: 0190-2148

    eISSN: 1521-0499

  45. Development of takotsubo cardiomyopathy during acute exacerbation of chronic inflammatory demyelinating polyneuropathy

    武井祐介, 小林孝史, 本田泉, 千葉聡子

    日本集中治療医学会雑誌(Web) 22 (6) 531‐535 (J‐STAGE)-535 2015

    Publisher: 一般社団法人 日本集中治療医学会

    DOI: 10.3918/jsicm.22.531  

    ISSN: 1882-966X

    More details Close

    We recently experienced a patient who developed stress cardiomyopathy during the course of chronic inflammatory demyelinating polyneuropathy (CIDP). The patient was a 56-year-old woman who developed CIDP at 45 years of age and experienced repeated exacerbation-remission cycles several times thereafter. The most recent CIDP occurrence caused left facial nerve paralysis and muscle weakness in both legs; therefore, she was admitted with a diagnosis of CIDP acute exacerbation. Respiratory muscle paralysis and limb paralysis occurred the day after she was admitted; she was put on a ventilator in the ICU, and intravenous immunoglobulin therapy was administered. After admission to the ICU, the patient&#039;s hemodynamics varied greatly. On day 3 after ICU admission, an echocardiogram showed wall motion abnormalities. The base of her heart showed normal contractions but akinesis at the apex, leading to the diagnosis of stress cardiomyopathy. She also had a fever higher than 40&amp;deg;C. Wall motion abnormality was improved by the seventh day after ICU admission, and her limb paralysis and fever also improved. Unlike in Guillain-Barr&amp;eacute; syndrome, which is related to CIDP, severe autonomic neuropathy in CIDP is rare. We speculate that severe autonomic neuropathy might have been a cause of takotsubo cardiomyopathy in this case.

  46. 救急外来における超音波ガイド下神経ブロックの検討

    民井亨, 小林孝史, 本田泉, 千葉聡子, 渋澤雅和, 武井祐介

    大崎市民病院誌 17 (1) 58-59 2013/11/29

    ISSN: 1881-6142

  47. 慢性炎症性脱髄性多発神経炎(CIDP)の経過中にたこつぼ心筋症を発症した一例

    武井祐介, 小林孝史, 本田泉, 渋澤雅和, 三輪明子

    日本集中治療医学会雑誌 20 (Supplement) 362 2013/01/25

    ISSN: 1340-7988

  48. [Anesthetic management of Y-shaped tracheobronchial stent insertion via tracheostomy site]. Peer-reviewed

    Tomomi Ii, Kazutomo Saito, Yusuke Takei, Yosuke Ito, Kei Nagaya

    Masui. The Japanese journal of anesthesiology 59 (5) 622-4 2010/05

    ISSN: 0021-4892

  49. 救急病棟に入院した感染症患者への抗生剤投与は適切だったか?

    齊藤和智, 小林孝史, 遠藤康弘, 武井祐介

    大崎市民病院誌 13 (1) 27-29 2009/12/24

    ISSN: 1881-6142

  50. 当院における過去6年間の新鮮血輸血と異型適合輸血の変化

    武井祐介, 小林孝史, 佐々木繁美, 遠藤康弘, 小野ゆき子, 斉藤和智, 氏家和明

    大崎市民病院誌 12 (1) 13-14 2008/12/22

    ISSN: 1881-6142

  51. くも膜下出血の手術におけるレミフェンタニル麻酔とフェンタニル麻酔の循環動態

    中村美帆, 小林孝史, 遠藤康弘, 佐々木繁美, 斉藤和智, 武井祐介

    臨床麻酔(真興交易) 32 (6) 1089-1090 2008/06/20

    ISSN: 0387-3668

Show all ︎Show first 5

Misc. 44

  1. 脊髄くも膜下麻酔による重症大動脈弁狭窄症合併大腿骨骨折手術後の循環器合併症 圧較差による比較

    安達 厚子, 山内 正憲, 武井 祐介, 石川 悠, 儘田 千尋, 川上 和宏

    Cardiovascular Anesthesia 29 (Suppl.) 245-245 2025/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  2. マイコプラズマ感染症に続発した寒冷凝集素症に対し血漿交換後に開心術を施行した1症例

    吾妻 佑希人, 宇賀神 咲久絡, 舟橋 優太郎, 千種 峻平, 武井 祐介, 金谷 明浩, 山内 正憲

    Cardiovascular Anesthesia 29 (Suppl.) 250-250 2025/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  3. 進行性の肺障害に対し,V-V ECMOブリッジで血液型不適合生体両肺移植に繋げた1例

    齋藤 宏樹, 入間田 大介, 山口 真一, 佐々木 純一, 高橋 和博, 小林 直也, 紺野 大輔, 武井 祐介, 山内 正憲

    日本集中治療医学会雑誌 32 (Suppl.2) S546-S546 2025/09

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  4. NRF2の人工呼吸関連肺傷害(VILI)におけるbiotrauma抑制効果の検討

    武井 祐介, 田口 恵子, 鈴木 隆史, 山田 充啓, 齋藤 和智, 江島 豊, 山内 正憲, 山本 雅之

    日本集中治療医学会雑誌 32 (Suppl.2) S564-S564 2025/09

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  5. 術中解離所見に先行した瞳孔記録計によるNeurological Pupil Index低下から脳虚血に対応し得た1症例

    安達 厚子, 亀山 良亘, 石川 悠, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 28 (1) 85-89 2024/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  6. 低侵襲僧帽弁形成術後の重症再膨張性肺水腫に対して体外式膜型人工肺を使用し救命した1症例

    関根 智宏, 武井 祐介, 儘田 千尋, 間島 卓哉, 熊谷 道雄, 太田 卓尚, 山内 正憲

    Cardiovascular Anesthesia 28 (Suppl.) 188-188 2024/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  7. 低侵襲心臓手術の術後鎮痛として前鋸筋面ブロックを実施し、術後疼痛管理チームが介入した2症例

    佐藤 友菜, 武井 祐介, 熊谷 道雄, 尾形 優子, 古山 彩郁, 山内 正憲

    Cardiovascular Anesthesia 28 (Suppl.) 232-232 2024/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  8. 胸部大動脈瘤の影響で下大静脈損傷をきたした胸腔鏡下左心耳閉鎖術

    古山 彩郁, 舟橋 優太郎, 関根 智宏, 尾形 優子, 熊谷 道雄, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 28 (Suppl.) 262-262 2024/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  9. 腹部緊急手術を要したLabile Obstruction型閉塞性肥大型心筋症患者の一例

    田中 捷馬, 尾形 優子, 太田 卓尚, 海法 悠, 鈴木 真奈美, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 28 (Suppl.) 268-268 2024/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  10. ミエリンオリゴデンドロサイト糖蛋白抗体関連疾患を有する妊婦の帝王切開術を全身麻酔で行った1例

    角田 博, 佐々木 規喜, 武井 祐介, 重田 惟, 石井 仁, 山内 正憲

    日本臨床麻酔学会誌 44 (3) 300-304 2024/05

    Publisher: 日本臨床麻酔学会

    ISSN: 0285-4945

    eISSN: 1349-9149

  11. 認知運動機能低下は無症候性の重症大動脈弁狭窄症患者に対する非心臓手術の転帰に影響するか

    安達 厚子, 石川 悠, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 27 (Suppl.) 259-259 2023/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  12. 最適な輸液管理のために LiDCOの活かし方

    武井 祐介

    日本集中治療医学会雑誌 29 (Suppl.1) 754-754 2022/11

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  13. 術中解離所見に先行した定量的瞳孔測定によるNeurological Pupil Index低下から脳虚血に対応し得た1症例

    安達 厚子, 石川 悠, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 26 (Suppl.) 219-219 2022/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  14. 下大静脈腫瘍進展を伴う腎細胞癌の腎摘出術中に発症した急性肺塞栓症の診断に経食道エコーが有用だった1例

    久保 良介, 武井 祐介, 高橋 みさき, 熊谷 道雄, 尾形 優子, 吉田 亜古, 山内 正憲

    Cardiovascular Anesthesia 26 (Suppl.) 225-225 2022/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  15. 2.成人先天性心疾患の非心臓手術麻酔管理

    外山裕章, 齊藤和智, 武井祐介, 高橋和博, 江島豊, 山内正憲

    循環制御(Web) 43 (2) 2022

    ISSN: 0389-1844

  16. 全身麻酔を回避し,末梢神経ブロック+鎮静のmonitored anesthesia care (MAC)で—左室流出路狭窄患者の大腿骨転子部骨折手術

    武井 祐介, 外山 裕章

    LiSA = リサ : Life support and anesthesia : 周術期管理を核とした総合誌 28 (6) 563-566 2021/06

    Publisher: 東京 : メディカル・サイエンス・インターナショナル

    ISSN: 1340-8836

  17. 肺高血圧症患者のリバースリモデリング 両肺移植前後の心室容積変化

    土肥 泰明, 外山 裕章, 武井 祐介, 江島 豊, 山内 正憲

    日本循環制御医学会総会プログラム・抄録集 41回 41-41 2021/02

    Publisher: 日本循環制御医学会

  18. 非原発性肺高血圧症における肺移植後の両心室機能に関する検討

    土肥泰明, 外山裕章, 武井祐介, 民井亨, 江島豊, 山内正憲

    日本麻酔科学会学術集会(Web) 68th 2021

  19. 開腹膵頭十二指腸切除術における経皮的酸素分圧の特性と手術部位感染

    相原孝典, 江島豊, 武井祐介, 海法悠, 外山裕章, 山内正憲

    日本麻酔科学会学術集会(Web) 68th 2021

  20. 静脈脱血静脈送血膜型人工肺は肺血管抵抗を減少する:肺移植症例における肺循環への影響の検討

    川治崇泰, 外山裕章, 武井祐介, 高橋和博, 江島豊, 山内正憲

    日本麻酔科学会学術集会(Web) 68th 2021

  21. 人工心肺使用手術における手術時間・出血量を予想する簡易スコアシステムの創出研究

    橋本侑子, 海法悠, 外山裕章, 武井祐介, 熊谷道雄, 山内正憲

    日本麻酔科学会学術集会(Web) 68th 2021

  22. 開心術中の右室機能変化と術後AKIに関する検討-心臓手術中における心腎相互作用-

    土肥泰明, 外山裕章, 武井祐介, 民井亨, 海法悠, 高橋和博

    Cardiovascular Anesthesia 25 (Suppl (CD-ROM)) 2021

    ISSN: 1342-9132

  23. 多発肋骨骨折によるフレイルチェストの疼痛管理に前鋸筋-肋間筋面ブロックを施行した一例

    渡辺 千晶, 亀山 良亘, 舟橋 優太郎, 民井 あかね, 武井 祐介, 齊藤 和智, 志賀 卓也, 齋藤 浩二, 江島 豊, 山内 正憲

    日本集中治療医学会雑誌 27 (Suppl.) 578-578 2020/09

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  24. Fontan循環患者の肝切除術 症例報告

    舟橋 優太郎, 武井 祐介, 吉田 亜古, 森 咲久絡, 早川 聖子, 早坂 知子, 山内 正憲

    Cardiovascular Anesthesia 23 (Suppl.) [DP2-02] 2019/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  25. TEVARにおける血圧管理について

    吉田 卓矢, 溝渕 知司, 森 咲久絡, 山内 正憲, 武井 祐介

    臨床麻酔 43 (8) 1113-1116 2019/08

    Publisher: 真興交易(株)医書出版部

    ISSN: 0387-3668

  26. 移植肺再灌流後の肺静脈内血栓を経食道心エコーで診断し得た1例

    森 咲久絡, 熊谷 道雄, 武井 祐介, 江島 豊, 宇井 あかね, 高橋 和博

    Cardiovascular Anesthesia 22 (Suppl.) 210-210 2018/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  27. 移植肺再灌流後の肺静脈内血栓を経食道心エコーで診断し得た1例

    森 咲久絡, 熊谷 道雄, 武井 祐介, 江島 豊, 宇井 あかね, 高橋 和博

    Cardiovascular Anesthesia 22 (Suppl.) 210-210 2018/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

  28. 経カテーテル的大動脈弁置換術における術後せん妄に関する危険因子の検討

    山田 結理, 尾形 優子, 武井 祐介, 吾妻 俊弘, 鈴木 真奈美, 山内 正憲

    Cardiovascular Anesthesia 22 (Suppl.) 156-156 2018/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  29. 経カテーテル大動脈弁置換術における経皮的心肺補助使用に関する因子の検討

    井汲 沙織, 吾妻 俊弘, 武井 祐介, 鈴木 真奈美, 山内 正憲

    Cardiovascular Anesthesia 22 (Suppl.) 182-182 2018/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

  30. 心房心室不一致かつ心室大血管不一致を有する症例への体心室補助人工心臓(VAD)導入術後の管理

    相原孝典, 外山裕章, 志賀卓弥, 熊谷道雄, 武井祐介, 吾妻俊弘, 江島豊, 齋藤浩二

    日本集中治療医学会学術集会(Web) 45th (Suppl.) ROMBUNNO.P65‐3 (WEB ONLY)-3] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

  31. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大場瑠璃, 亀山良亘, 志賀卓弥, 金谷明浩, 武井祐介, 齊藤和智, 山内正憲

    日本集中治療医学会学術集会(Web) 45th (Suppl.) ROMBUNNO.P83‐1 (WEB ONLY)-1] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

  32. 心房心室不一致かつ心室大血管不一致を有する症例への体心室補助人工心臓(VAD)導入術後の管理

    相原 孝典, 外山 裕章, 志賀 卓弥, 熊谷 道雄, 武井 祐介, 吾妻 俊弘, 江島 豊, 齋藤 浩二

    日本集中治療医学会雑誌 25 (Suppl.) [P65-3] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  33. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大塲 瑠璃, 亀山 良亘, 志賀 卓弥, 金谷 明浩, 武井 祐介, 齊藤 和智, 山内 正憲

    日本集中治療医学会雑誌 25 (Suppl.) [P83-1] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  34. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌 25 (Suppl.) [O69-2] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  35. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌 25 (Suppl.) [O69-2] 2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

  36. 心臓外科手術中の前額部局所酸素飽和度(rSO2)と混合静脈血酸素飽和度(Sv(_)O2)の関連の検討

    尾形 優子, 宇井 あかね, 吉田 亜古, 民井 亨, 武井 祐介, 山内 正憲

    Cardiovascular Anesthesia 21 (Suppl.) 294-294 2017/09

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

    eISSN: 1884-7439

  37. 肺循環・肺損傷 ACE陽性EMPに着目した新規ARDSバイオマーカーの開発

    武井 祐介, 山田 充啓, 藤野 直也, 斎藤 浩二, 山内 正憲, 杉浦 久敏, 一ノ瀬 正和

    日本呼吸器学会誌 6 (増刊) 124-124 2017/03

    Publisher: (一社)日本呼吸器学会

    ISSN: 2186-5876

    eISSN: 2186-5884

  38. 開胸手術後に縦隔炎を合併し、長期の経口挿管管理を要した二例

    宇井 あかね, 亀山 良亘, 吾妻 俊弘, 金谷 明浩, 武井 祐介, 江島 豊, 齋藤 浩二

    日本集中治療医学会雑誌 24 (Suppl.) DP20-4 2017/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

  39. 小児劇症型心筋炎に対し早期のCentral ECMOを導入し救命し得た1例

    金谷 明浩, 亀山 良亘, 武井 祐介, 志賀 卓弥, 吾妻 俊弘, 江島 豊, 齋藤 浩二, 山内 正憲

    日本集中治療医学会雑誌 24 (Suppl.) O8-5 2017/02

    Publisher: (一社)日本集中治療医学会

    ISSN: 1340-7988

    eISSN: 1882-966X

  40. 閉塞性血栓血管炎の手指症状に対して両側持続腕神経叢ブロックが奏功した一例

    齋藤 秀悠, 武井 祐介, 田島 つかさ, 村上 徹, 大西 詠子, 志賀 卓弥, 山内 正憲

    日本ペインクリニック学会誌 23 (2) 139-139 2016/06

    Publisher: (一社)日本ペインクリニック学会

    ISSN: 1340-4903

    eISSN: 1884-1791

  41. 経皮的心肺補助中に左室内巨大血栓を形成した巨細胞性心筋炎の一例

    武井 祐介, 土肥 泰明, 民井 亨, 阿部 望, 海法 悠, 戸田 法子, 山内 正憲

    Cardiovascular Anesthesia 19 (Suppl.) 223-223 2015/10

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

  42. 当院における経大腿動脈アプローチによるTAVI症例の術中管理と術後経過

    黒瀧 健二, 吾妻 俊弘, 戸田 法子, 武井 祐介, 民井 亨, 阿部 望, 山内 正憲

    Cardiovascular Anesthesia 19 (Suppl.) 237-237 2015/10

    Publisher: (一社)日本心臓血管麻酔学会

    ISSN: 1342-9132

  43. 周術期に椎骨動脈瘤の破裂を合併したvon Recklinghausen病の一症例

    熊谷 道雄, 小林 直也, 太田 卓尚, 早坂 知子, 武井 祐介, 外山 裕章, 江島 豊, 山内 正憲

    日本臨床麻酔学会誌 34 (6) S326-S326 2014/10

    Publisher: 日本臨床麻酔学会

    ISSN: 0285-4945

    eISSN: 1349-9149

  44. スマートポンプによるカテコラミンの薬液自動更新は、循環動態への影響を抑制するか

    小林 直也, 齋藤 浩二, 武井 祐介, 志賀 卓弥, 亀山 良亘, 星 邦彦, 山内 正憲

    臨床モニター 25 (Suppl.) 59-59 2014/04

    Publisher: 医学図書出版(株)

    ISSN: 0915-6976

Show all ︎Show first 5

Presentations 23

  1. 脳死片肺移植術中に膜型人工肺(ECMO)使用を予見させる因子の後ろ向き検討

    久保良介, 小林直也, 外山裕章, 武井祐介, 江島豊, 山内正憲

    日本麻酔科学会学術集会(Web) 2019

  2. 敗血症における内皮微小粒子の動態

    武井祐介

    日本麻酔科学会学術集会(Web) 2019

  3. Circulating Ace+ EMPs Are a Potential Marker for Evaluating Pulmonary Endothelial Injury During ARDS International-presentation

    Y. Takei, M. Yamada, K. Saito, Y. Kameyama, H. Sugiura, T. Makiguchi, N. Fujino, H. Toyama, K. Saito, Y. Ejima, Y. Kawazoe, D. Kudo, S. Kushimoto, M. Yamauchi, M. Ichinose

    2018 ATS international conference 2018/05/23

  4. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井祐介, 齋藤浩二, 亀山良亘, 齊藤和智, 金谷明浩, 杉野繁一, 吾妻俊弘, 江島豊, 志賀卓弥, 山内正憲

    日本集中治療医学会学術集会(Web) 2018

  5. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大場瑠璃, 亀山良亘, 志賀卓弥, 金谷明浩, 武井祐介, 齊藤和智, 山内正憲

    日本集中治療医学会学術集会(Web) 2018

  6. 経カテーテル大動脈弁置換術における経皮的心肺補助使用に関する因子の検討

    井汲沙織, 吾妻俊弘, 武井祐介, 鈴木真奈美, 山内正憲

    Cardiovascular Anesthesia 2018

  7. 心房心室不一致かつ心室大血管不一致を有する症例への体心室補助人工心臓(VAD)導入術後の管理

    相原孝典, 外山裕章, 志賀卓弥, 熊谷道雄, 武井祐介, 吾妻俊弘, 江島豊, 齋藤浩二

    日本集中治療医学会学術集会(Web) 2018

  8. 移植肺再灌流後の肺静脈内血栓を経食道心エコーで診断し得た1例

    森咲久絡, 熊谷道雄, 武井祐介, 江島豊, 宇井あかね, 高橋和博

    Cardiovascular Anesthesia 2018

  9. 経カテーテル的大動脈弁置換術における術後せん妄に関する危険因子の検討

    山田結理, 尾形優子, 武井祐介, 吾妻俊弘, 鈴木真奈美, 山内正憲

    Cardiovascular Anesthesia 2018

  10. ACE陽性EMPに関した新規ARDSバイオマーカーの開発

    武井祐介, 山田充啓, 藤野直也, 斎藤浩二, 山内正憲, 杉浦久敏, 一ノ瀬正和, 一ノ瀬正和

    日本呼吸器学会誌(Web) 2017/03/10

  11. 開胸手術後に縦隔炎を合併し,長期の経口挿管管理を要した二例

    宇井あかね, 亀山良亘, 吾妻俊弘, 金谷明浩, 武井祐介, 江島豊, 齋藤浩二

    日本集中治療医学会学術集会(Web) 2017

  12. 小児劇症型心筋炎に対し早期のCentral ECMOを導入し救命し得た1例

    金谷明浩, 亀山良亘, 武井祐介, 志賀卓弥, 吾妻俊弘, 江島豊, 齋藤浩二, 山内正憲

    日本集中治療医学会学術集会(Web) 2017

  13. 心臓外科手術中の前額部局所酸素飽和度(rSO2)と混合静脈血酸素飽和度(Sv(_)O2)の関連の検討

    尾形優子, 宇井あかね, 吉田亜古, 民井亨, 武井祐介, 山内正憲

    Cardiovascular Anesthesia 2017

  14. Difference in specificities according to systemic vascular resistance index between simultaneous measurements by the Flo Trac and LiDCO Rapid systems during cardiac surgery International-presentation

    TAKEI YUSUKE, YUTAKA EJIMA, HIROAKI TOYAMA, MASANORI YAMAUCHI

    the anesthesiology annual meeting 2016 2016/10/24

  15. 当院における経大腿動脈アプローチによるTAVI症例の術中管理と術後経過

    黒瀧健二, 吾妻俊弘, 戸田法子, 武井祐介, 民井亨, 阿部望, 山内正憲

    Cardiovascular Anesthesia 2015

  16. 経皮的心肺補助中に左室内巨大血栓を形成した巨細胞性心筋炎の一例

    武井祐介, 土肥泰明, 民井亨, 阿部望, 海法悠, 戸田法子, 山内正憲

    Cardiovascular Anesthesia 2015

  17. 周術期に椎骨動脈瘤の破裂を合併したvon Recklinghausen病の一症例

    熊谷道雄, 小林直也, 太田卓尚, 早坂知子, 武井祐介, 外山裕章, 江島豊, 山内正憲

    日本臨床麻酔学会誌 2014/10/01

  18. スマートポンプによるカテコラミンの薬液自動更新は,循環動態への影響を抑制するか

    小林直也, 齋藤浩二, 武井祐介, 志賀卓弥, 亀山良亘, 星邦彦, 山内正憲

    臨床モニター 2014/04/18

  19. LIPを測定するSlice methodのソフトの開発

    亀山良亘, 星邦彦, 武井祐介, 吾妻俊弘, 齋藤浩二, 鈴木健一

    日本呼吸療法医学会学術総会プログラム・抄録集 2010

  20. 東北大学病院における肺移植症例の検討

    武井祐介, 星邦彦, 亀山良亘, 吾妻俊弘, 齋藤浩二, 黒澤伸

    日本呼吸療法医学会学術総会プログラム・抄録集 2010

  21. 劇症型肺炎球菌感染症の2症例

    武井祐介, 小林孝史, 佐々木繁美, 遠藤康弘, 小野ゆき子, 斉藤和智

    麻酔 2009/03/10

  22. 敗血症性ショックに対する治療後にsymmetrical peripheral gangreneのため四肢切断に至った2症例

    小野ゆき子, 小林孝史, 斉藤和智, 武井祐介

    日本集中治療医学会雑誌 2009/01/20

  23. 当救命センターにおける急性脳症に対しての小児脳低温療法の検討

    武井祐介, 斎藤和智, 工藤充哉, 斎藤明子, 上野和之, 岩城利充

    日本小児科学会雑誌 2007/09/01

Show all Show first 5

Research Projects 9

  1. 心大血管手術に伴う腎血管内細胞障害による腎不全発症機序の解明と治療法開発

    外山 裕章, 阿部 望, 齊藤 和智, 武井 祐介

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2028/03/31

  2. Attempts to utilize NRF2 to reduce biotrauma in ventilator-induced lung injury

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  3. Elucidation of the dynamics and pathophysiological role of microparticles in septic DIC

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04 - 2023/03

  4. Elucidation of pathophysiological role of endothelial microparticles for endothelial injury in ventilatior-induced lung injury

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04 - 2023/03

  5. Treatment strategy for severe COVID-19 induced coagulopathy based on the specific mechanisms

    2020/08 - 2021/03

  6. The elucidation and pathophyological function of endothelial micro particles in sepsis

    Saito Koji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04 - 2021/03

    More details Close

    Inflammatory stimulation to human umbilical vein endothelial cells (HUVECs) increased EMPs in a concentration-dependent manner. The circulating EMPs in patients with sepsis were significantly increased compared to non-septic patients, reflecting vascular endothelial injury. In addition, PECAM + EMPs and VE-cadherin + EMPs were significantly increased in septic shock patients compared to septic patients. When vascular permeability is changed to HUVECs by permeability modifying agents, PECAM + EMPs and VE-cadherin + EMPs were consistent with changes in vascular permeability and their release was altered, so that PECAM + EMPs and VE-cadherin + EMPs might be novel indicators of vascular permeability in sepsis.

  7. 敗血症における内皮微小粒子の動態の解明 Competitive

    武井 祐介

    Offer Organization: 日本麻酔科学会

    System: 研究支援事業 ピッチコンテスト

    2018/07 - 2020/06

  8. The dynamics of endothelial microparticles in ventilator related lung injury (VILI) and the effect of sevoflurane on endothelial injury n VILI

    TAKEI YUSUKE

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up

    Category: Grant-in-Aid for Research Activity start-up

    Institution: Tohoku University

    2018/08 - 2020/03

    More details Close

    We reported that lung-derived circulating Endothelial Microparticles (EMPs) increased in acute lung injury, reflecting pulmonary endothelial injury. Furthermore, it were strongly correlated with the severity of vascular hyper-permeability in acute lung injury. In addition, we showed that the number of circulating EMPs increased in patients with sepsis, and that PECAM+EMPs and VE-cadherin+EMPs could be a novel indicator of vascular hyper-permeabilitiy. We established more stable VILI rat model by administering muscle relaxants to eliminate the effect of spontaneous breathing with precise ventilator that enables high volume ventilation of 20 ml / kg accurately for small animals.

  9. The role of endothelial microparticles in ARDS

    Saito Kouji, Takei Yusuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2015/04 - 2018/03

    More details Close

    We investigated the role of the angiotensin+ endothelial microparticles (ACE+EMPs) as a pulmonary endothelial injury. More ACE+EMPs were released from Human pulmonary microvascular endothelial cells than other endothelial cells and increased by inflammatory stimuli. Circulating ACE+EMPs were significantly higher in septic patients with ARDS than patients without ARDS. Furthermore, ACE+EMPs increased significantly in mouse lung injury model and correlate with the severity of pulmonary microvascular permeability. Circulating ACE+ EMPs could therefore be a useful marker for evaluating pulmonary endothelial injury during ARDS.

Show all Show first 5