Details of the Researcher

PHOTO

Yospanya Wijak
Section
Advanced Institute for Materials Research
Job title
Assistant Professor
Degree

  • Ｐｈ．Ｄ．（University of Bordeaux）

  • 博士（理学）（東北大学）

  • 修士（理学）（東北大学）

e-Rad No.
00897978
Researcher ID
IQU-5894-2023

Research History 3

  • 2023/03 - Present
    Tohoku University　Advanced Institute for Materials Research

  • 2021/04 - 2023/02
    Tokyo Institute of Technology　School of Life Science and Technology

  • 2020/10 - 2021/03
    Tokyo Institute of Technology　School of Life Science and Technology

Education 4

  • University of Bordeaux　Doctoral School of Chemical Science　Doctoral Course

    2017/10 - 2020/09

  • Tohoku University　Graduate School of Science　Doctoral Course (IGPAS)

    2017/10 - 2020/09

  • Tohoku University　Graduate School of Science　Master Course (IGPAS)

    2015/10 - 2017/09

  • Tohoku University　Faculty of Science　Undergraduate Course (Advanced Molecular Chemistry)

    2011/10 - 2015/09

Professional Memberships 4

  • The Society of Polymer Science, Japan

    2022/04 - Present

  • The Japanese Photochemistry Association

    2015/09 - Present

  • The Chemical Society of Japan

    2015/04 - Present

  • Thai Students’ Association in Japan under Royal Patronage

    2011/10 - Present

Research Interests 5

  • Surfactants

  • Nanomaterials

  • Organic Chemistry

  • Chirality

  • Photochemistry

Research Areas 6

  • Nanotechnology/Materials / Organic functional materials /

  • Nanotechnology/Materials / Optical engineering and photonics /

  • Nanotechnology/Materials / Biochemistry /

  • Nanotechnology/Materials / Nanobioscience /

  • Nanotechnology/Materials / Green/sustainable/environmental chemistry /

  • Nanotechnology/Materials / Nanostructure chemistry /

Awards 10

  1. Jury Best Oral Presentation Award

    2019　The 12th Edition of Young Scientists Symposium

  2. Excellent Presentation Award (Industry)

    2017　The Chemical Society of Japan

  3. Excellent Student Poster Presentation Award

    2016　The Japanese Photochemistry Association

  4. Bachelor’s Degree Conferment Valedictorian

    2015/09　Tohoku University

  5. Thai Royal Student Award

    2007　Bureau of the Royal Household

  6. Speech Valedictorian (understudy)

    2017/09　Tohoku University

  7. Top 10% Finalists for Student Poster Presentation Award

    2015　International Chemical Congress of Pacific Basin Societies (PACIFICHEM)

  8. High Distinction Award

    2009　Australian National Chemistry Quiz Thailand

  9. National Winner of Quiz Competition

    2008　SCB Challenge Thailand

  10. High Distinction Award

    2008　Australian National Chemistry Quiz Thailand

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Papers 9

  1. Design of cyborg proteins by loop region replacement with oligo(ethylene glycol): exploring suitable mutations for cyborg protein construction using machine learning Invited Peer-reviewed

    Wijak Yospanya, Akari Matsumura, Yukihiro Imasato, Tomoyuki Itou, Yusuke Aoki, Hikaru Nakazawa, Takashi Matsui, Takeshi Yokoyama, Mihoko Ui, Mitsuo Umetsu, Satoru Nagatoishi, Kouhei Tsumoto, Yoshikazu Tanaka, Kazushi Kinbara

    Bulletin of the Chemical Society of Japan　97　(9)　2024/09/02

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/bulcsj/uoae090 　

    ISSN： 0009-2673

    eISSN： 1348-0634

    More details Close

    Abstract We synthesized a “cyborg protein,” wherein a synthetic molecule partially substitutes the main peptide chain by linking 2 protein domains with a synthetic oligomer. Green fluorescent protein (GFP) served as the model for constructing the cyborg proteins. We prepared circularly permuted GFP (cpGFP) with new termini between β10 and β11, where the original N- and C-termini were linked by a cleavable peptide loop. The cyborg GFP was constructed from cpGFP by linking the β10 and β11 with oligo(ethylene glycol) (OEG) using maleimide–cysteine couplings, followed by the enzymatic cleavage of the N- and C-termini linking loop by thrombin. With the help of machine learning, we were able to obtain the cpGFP mutants that significantly alter the fluorescence intensity (53% increase) by thrombin treatment, which splits cpGFP into 2 fragments (fragmented GFP), and by heat shock. When the cyborg GFP was constructed using this mutant, the fluorescence intensity increased by 13% after heat treatment, similar to cpGFP (33% increase), and the behavior was significantly different from that of the fragmented GFP. This result suggests the possibility that the OEG chain in the cyborg protein plays a similar role to the peptide in the main chain of the protein.

  2. Monitoring insulin fibrillation kinetics using chromatographic analysis Peer-reviewed

    Pituwala Kankanamge Thirasara Sammani, Wijak Yospanya, Tatsuya Niwa, Ai Kohata, Hideki Taguchi, Kazushi Kinbara

    International Journal of Biological Macromolecules　275　133660-133660　2024/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.ijbiomac.2024.133660 　

    ISSN： 0141-8130

  3. Near-unity angular anisotropy of circularly polarized luminescence from microspheres of monodispersed chiral conjugated polymers Peer-reviewed

    Sota Nakayama, Hiroshi Yamagishi, Osamu Oki, Soh Kushida, Junhui Chen, Junpei Kuwabara, Takaki Kanbara, Wijak Yospanya, Reiko Oda, Yohei Yamamoto

    Chemical Communications　60　(59)　7634-7637　2024

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4cc01428f 　

    ISSN： 1359-7345

    eISSN： 1364-548X

    More details Close

    A microsphere, assembled from a chiral π-conjugated polymer, features a well-organized twisted-bipolar structure and exhibits circularly polarized luminescence with near-unity angular anisotropy.

  4. Multiblock Amphiphilic Triptycene toward Bioinspired Molecular Rotor in Membrane Peer-reviewed

    Yospanya, W., Sato, K., Kinbara, K.

    Chemistry Letters　51　(10)　1026-1028　2022/10/05

    Publisher: The Chemical Society of Japan

    DOI： 10.1246/cl.220360 　

    ISSN： 1348-0715 0366-7022

  5. Near perfect head-to-head selectivity on the supramolecular photocyclodimerisation of 2-anthracenecarboxylate with self-organised gemini surfactant bilayers Peer-reviewed

    Yospanya, W., Nishijima, M., Araki, Y., Buffeteau, T., Pouget, E., Wada, T., Oda, R.

    Chemical Communications　56　(69)　10058-10061　2020

    Publisher: Royal Society of Chemistry ({RSC})

    DOI： 10.1039/d0cc04198j 　

    ISSN： 1364-548X 1359-7345

  6. Induced blue, green, and red-colour circularly polarized luminescence from single dye-doped homochiral poly(lactic acid) microspheres Peer-reviewed

    Suharman, Sota Nakayama, Soh Kushida, Sundas Rani, Wijak Yospanya, Piyanan Pranee, Reiko Oda, Hiroshi Yamagishi, Yohei Yamamoto

    Journal of Materials Chemistry C　2025

    DOI： 10.1039/D5TC01506E 　

  7. Chirality expression from hierarchical foldamer-mesoscopic helical silica frameworks Peer-reviewed

    Piyanan Pranee, Robin Hess, Anthony Boudier, Zakaria Anfar, Matheus De Souza Lima Mendes, Eric Merlet, Wijak Yospanya, Emilie Pouget, Sylvain Nlate, Céline Olivier, Thierry Buffeteau, Yann Ferrand, Reiko Oda

    Materials Chemistry Frontiers　2025

    DOI： 10.1039/D4QM01140F 　

  8. Amphiphilic structured PEG derivatives suppressing protein thermal aggregation at extremely low molecular ratio

    Adam Wawro, Takahiro Muraoka, Wijak Yospanya, Mayu Kawame, Yudai Nakagawa, Mihoko Ui, Pawel Antonik, Peter Crowley, Kouhei Tsumoto, Kazushi Kinbara

    2023/02/09

    Publisher: American Chemical Society (ACS)

    DOI： 10.26434/chemrxiv-2023-439sw 　

    More details Close

    Amphiphilic structured PEG derivatives consisting of octa(ethylene glycol) chains connected with aromatic vertices inhibited the thermally-induced lysozyme aggregation even when present at below 0.1 mM concentration. This concentration range is close to a 1:1 molar ratio with the additive and lysozyme, and was completely inaccessible for previously reported stabilizers. The possible mechanisms of the stabilizing actions revealed that the PEG-based amphiphiles do not in fact prevent aggregation at the molecular level, as assumed before, but rather prevent macroscopic precipitation of the denatured protein molecules and enable dissolution of them to the native, folded state at ambient temperature. The stabilizers do not interact with properly folded native lysozyme and therefore do not affect its natural catalytic properties, indicating a potential for practical use in protein-based therapeutics.

  9. Studies on Supramolecular Photochirogenesis Mediated by Synthetic Antibody and Chiral Silica-Organic Hybrid Nanoribbons

    2020/09/25

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Presentations 38

  1. Exploring the Potential of Proteins Beyond their Native Environments: Toward Versatile and Sustainable Advanced Materials Invited

    Connecting Expertise: Collaborative Innovations in Materials and Energy Science　2025/03/17

  2. Design of Cyborg Proteins by Loop Region Replacement With Oligo(ethylene glycol)

    The 18th Symposium on Biorelevant Chemistry　2024/09/12

  3. Fabrication of Chiral Mesoscopic Silica Nanohelices: Revisiting The Mechanism And Scale-Up Syntheses

    Chirality 2024　2024/08/28

  4. Chirality Induction of 2-Anthracenecarboxylate in Organic-Silica Nanoribbons And Its Regioselective Photocyclodimerization

    Advanced Material Research Grand Meeting MRM2023/IUMRS-ICA2023　2023/12/15

  5. IMRAM Organic/Life/Measurement Science Research Exchange Seminar Invited

    2023/12/04

  6. Induced Circular Dichroism of Anthracenecarboxylate in Organic-Silica Nanoribbons

    19th International Conference on Chiroptical Spectroscopy (CD2023)　2023/09/17

  7. Supramolecular Regioselective Photocyclodimerization of 2-Anthracenecarboxylate in Confined Cavities of Organic-Silica Nanoribbons

    The 31st International Conference on Photochemistry (ICP 2023)　2023/07/24

  8. Optimization of Amphiphilic Oligo(ethylene glycol) Structure for Suppression of Protein Thermal Aggregations

    SPSJ International Polymer Conference (IPC2023)　2023/07/20

  9. Amphiphilic oligo(ethylene glycol)s as protein stabilizers: effect of structure Invited

    71st Symposium on Macromolecules　2022/09/06

  10. Triptycene-based oligo(ethylene glycol) amphiphile: Synthesis and applications in aqueous solution

    The 102nd CSJ Annual Meeting　2022/03/25

  11. Supramolecular asymmetric photochirogenesis of 2-anthracene carboxylate dimers in synthetic antibody and silica hybrid nanofibers

    Young Scientist Symposium 12th Edition　2019/05/24

  12. Nanohelices for Chiral Light-Matter Interactions Fabrications of Different Chiral Nanohelical Materials and Their Applications

    Chirality-related dynamic phenomena　2025/03/10

  13. Chirality induction and regioselective photocyclodimerization of anthracene-2-carboxylate in organic-silica nanoribbons

    Pure and Applied Chemistry International Conference 2025　2025/02/14

  14. Exploring the Potential of Proteins Beyond Their Natural Environments Invited

    NEXUS Thailand-Japan Bilateral Research Exchange Symposium　2025/01/16

  15. Nanohelices for Chiral Light-Matter Interactions: Fabrications of Different Chiral Nanohelical Materials and Their Application

    Italia-Japan Binational Conference on Chiroptical and Related Phenomena　2025/01/07

  16. Unique Chemical Reactions Inside Confined Nanospace of Chiral Silica Nano-Template

    The 10th International Symposium on Functional Materials 2024　2024/08/05

  17. Nanohelices for Chiral Light-Matter Interactions: Fabrications of Different Chiral Nanohelical Materials and Their Applications

    OIST-JST-AIMR Joint International Symposium: Interaction Between Various Chiral Fields and Chiral Materials　2024/06/06

  18. Invited Presentation at Minami-Laboratory, Kobe University Invited

    2023/12/18

  19. AIMR Tea Time Invited Talk Invited

    2023/11/10

  20. Effect of Hydrophobic Aromatic Group on Amphiphilic Oligo(ethylene glycol)s as Lysozyme Stabilizers

    The 16th Symposium on Biorelevant Chemistry　2022/09/10

  21. Amphiphilic Oligo(ethylene glycol)s as Protein Stabilizers: Effect of Structure

    23rd Biopolymer Symposium　2022/07/29

  22. Supramolecular Asymmetric Photochirogenesis of 2-Anthracenecarboxylate Dimers in Chiral Medias: From Synthetic Antibody to Silica Hybrid Nanofibers

    The 5th International Symposium of Quantum Beam Science at Ibaraki University　2020/11/20

  23. Supramolecular asymmetric photochirogenesis of 2-anthracenecarboxylate dimers in chiral medias: from synthetic antibodies to silica hybrid nanofibers

    2nd edition of the International Symposium of CEFMS-NCTU, RCAS-AS (Taiwan) and 5-star Alliance (Japan)　2019/11/04

  24. Supramolecular asymmetric photochirogenesis of 2-anthracene carboxylate dimers in chiral medias: from synthetic antibodies to silica hybrid nanofibers

    31st International Symposium of Chirality　2019/07/16

  25. Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: photocyclodimerization of 2-anthracenecarboxylate mediated by synthetic scFv antibody

    27th IUPAC International Symposium on Photochemistry　2018/07

  26. Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: New ligand design in phage display technique for [4+4] photodimerization of 2-anthracenecarboxylate

    The 98th CSJ Annual Meeting　2018/03/20

  27. Toward A Novel Strategy for Sustainable Eco-Friendly Asymmetric Syntheses: Supramolecular Asymmetric Photodimerization of 2-Anthracenecarboxylate Mediated by Synthetic Antibody

    Kick-off Symposium for World Leading Research Centers - Materials Science and Spintronics -　2018/02/19

  28. Supramolecular Asymmetric Photochirogenesis Mediated by Synthetic Antibody: Controlling the photoreaction by external factors included solvent effects

    Annual Meeting on Photochemistry　2017/09/04

  29. Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: Controlling the photoreaction by external factors

    Tohoku University's Chemistry Summer School　2017/08

  30. Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: asymmetric photocyclodimerization of 2-anthracenecarboxylate mediated by synthetic scFv antibody

    The 28th International Conference on Photochemistry (ICP 2017)　2017/07

  31. Toward A Novel Strategy for Sustainable Eco-Friendly Asymmetric Syntheses: Supramolecular Asymmetric Photodimerization of 2-Anthracenecarboxylate Mediated by Synthetic Antibody

    The 97th CSJ Annual Meeting　2017/03/16

  32. Supramolecular Asymmetric Photochirogenesis Mediated by Synthetic Antibody: Controlling the photoreaction by external factors included solvent effects

    Annual Meeting on Photochemistry　2016/09/06

  33. Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: The effect of temperature upon photodimerization of 2- anthracenecarboxylate mediated by scFv antibody

    The 96th CSJ Annual Meeting　2016/03/26

  34. 4 Supramolecular asymmetric photochirogenesis mediated by synthetic antibody: Ground- and excited-states interaction studies of synthetic antibody with 2-anthracenecarboxylate

    2015 International Chemical Congress of Pacific Basin Societies　2015/12/15

  35. Supramolecular Asymmetric Photochirogenesis Mediated by Synthetic Antibody: Controlling the photoreaction by external factors included solvent effects

    Annual Meeting on Photochemistry　2015/09

  36. Supramolecular Asymmetric [4+4] Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Synthetic scFv

    Tohoku University's Chemistry Summer School　2015/08

  37. Supramolecular Asymmetric Photochiro- genesis Mediated by Synthetic Antibody 2: - Interaction Study of 2-Anthracenecarboxylate Dimer Recognized Single Chain Antibody Properties

    25th Biopolymer Symposium　2015/07/23

  38. Supramolecular Asymmetric Photochirogenesis Mediated by Synthetic Antibody-1 - Preparation of 2-Anthracenecarboxylate Dimer Recognized Single Chain Antibody

    The 95th CSJ Annual Meeting　2015/03/27

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Research Projects 2

  1. Nanometrical Helical Gold for multi-scale chiral recognition

    Reiko Oda, Kazuhiro Fukami

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04 - 2026/03

  2. Development of Anticancer Drugs – Improving Anticancer Therapeutic Effects Using Chiral Nanostructures

    Wijak Yospanya, Farsai Taemaitree

    Offer Organization: Hirose Foundation

    System: Research Grant

    Institution: Advanced Institute of Materials Research

    2024/01 - 2025/12

Media Coverage 1

  1. "Wijak," a Japanese scholarship student 'Let's do research to develop the country'

    Thairath　Hi Campus　Thailand

    2014/10

    Type: Newspaper, magazine