Details of the Researcher

PHOTO

Kazushi Ukishiro
Section
Tohoku University Hospital
Job title
Senior Assistant Professor
Degree

  • 博士（医学）（横浜市立大学）

e-Rad No.
40893962
Profile

E（エンジニア）資格保持　一般社団法人日本ディープラーニング協会

現在は、てんかん発作予測アルゴリズムの開発、脳梁離断術の研究をメインに行なっています。

Education 1

  • Kagoshima University　Faculty of Medicine

    2005/04 - 2011/03

Research Areas 3

  • Life sciences / Neuroscience - general /

  • Life sciences / Neurosurgery /

  • Life sciences / Nervous system function /

Awards 3

  1. SENDAI Global Startup Base

    2024/07　Sendai city

  2. SENDAI Global Startup Campus stage 1,2,3 (SGSC)

    2023/07　Sendai city

  3. 2023年度 日本てんかん学会 Sponsored Award (UCB 賞)

    2023/03　日本てんかん学会

Papers 29

  1. Age-Related Recovery of Daily Living Activity After 1-Stage Complete Corpus Callosotomy: A Retrospective Analysis of 41 Cases. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Nobukazu Nakasato

    Neurosurgery　90　(5)　547-551　2022/02/09

    DOI： 10.1227/NEU.0000000000001871 　

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    BACKGROUND: Recovery time after corpus callosotomy (CC) is known to be longer in elderly than in younger patients. OBJECTIVE: To evaluate the relationship between patient age and recovery time of activities of daily living (ADL) after 1-stage complete CC. METHODS: This study included 41 patients (22 women; aged 13 months-34 years, median 7 years) who underwent 1-stage complete CC for medically intractable seizures with drop attacks, infantile spasms, and/or bilaterally synchronized electroencephalographic discharges between August 2009 and April 2019. The timing of restart of competence in 5 ADL categories and surgical outcomes were recorded. RESULTS: Patients (1) restarted speech at 2.2 ± 1.3 (mean ± 2 standard deviations; range 1-5) days, (2) restarted replying with their own name on request at 5.5 ± 8.6 (2-33) days, (3) restarted oral intake at 1.6 ± 1.7 (1-11) days, (5) discontinued intravenous feeding at 6.0 ± 3.0 (2-16) days, and (5) restarted ambulation or wheelchair movement at 5.8 ± 3.4 (2-10) days. Younger patients showed significantly (P < .0223) earlier recovery of ambulation or wheelchair movement, but no age difference was found in the other 4 ADL categories. Overall seizure freedom was achieved in 5 patients, excellent (>80%) seizure reduction in 11, good (50%-80%) seizure reduction in 5, and poor (<50%) seizure reduction in 20. CONCLUSION: Early ADL recovery after 1-stage complete CC is favorable in both young and adult patients. These findings, with good surgical outcomes, will encourage more positive consideration of 1-stage complete CC in both pediatric and adult patients.

  2. Localization of the Epileptogenic Zone Using Neural Spatial Volatility in Epilepsy Surgery. International-journal Peer-reviewed

    Naoto Kuroda, Hiroshi Uda, Keiki Inoue, Yu Kitazawa, Shin-Ichiro Osawa, Hitoshi Nemoto, Makoto Ishida, Kazushi Ukishiro, Aimee F Luat, Hidenori Endo, Nobukazu Nakasato, Eishi Asano

    Neurology　105　(4)　e213906　2025/08/26

    DOI： 10.1212/WNL.0000000000213906 　

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    BACKGROUND AND OBJECTIVES: Diseased tissues in the human brain frequently exhibit marked alterations in structural and functional properties compared with adjacent, unaffected regions, whereas healthy tissues display intrinsic, milder topographical variability in these properties. We hypothesized that the epileptogenic zone responsible for drug-resistant focal seizures would be characterized by pronounced alterations in electrographic properties relative to adjacent regions. METHODS: This international, multicenter observational study aimed to test this hypothesis by studying patients with drug-resistant focal epilepsy who underwent curative epilepsy surgery following intracranial EEG (iEEG) recording, with at least 1 year of postoperative follow-up. In this study, "neural spatial volatility" was defined as differences in interictal high-frequency electrographic measures compared with adjacent areas. We tested whether greater neural spatial volatility in resected compared to preserved sites predicts postoperative seizure freedom, independently of clinical, neuroimaging, and ictal iEEG data. In addition, we examined whether incorporating neural spatial volatility into an outcome prediction model, based on the standard-care presurgical evaluation, would improve its performance. RESULTS: In a derivation cohort of 140 patients with 14,933 samples of iEEG electrodes (mean age 13.1 years; female 68 [48.6%]; postoperative seizure freedom 98 [70.0%]), greater neural spatial volatility in resected compared with preserved sites was an independent predictor of postoperative seizure freedom. The outcome prediction model considering the neural spatial volatility improved the classification performance, showing the area under the curve up to 0.825 (95% CI 0.747-0.902; p < 1.0 × 10-15). This result was validated in an independent test dataset of 26 patients with 1,626 samples of iEEG electrodes (mean age 25.7 years; female 14 [53.8%]; postoperative seizure freedom 16 [61.5%]) at a different institution, showing the improvement of prediction performance up to 0.819 (95% CI 0.653-0.985; p < 0.0005). DISCUSSION: Despite the limitations of the retrospective study and the relatively small validation cohort, our findings suggest that increased heterogeneity in the mesoscale distribution of interictal high-frequency activity is a distinguishing feature of the epileptogenic zone in drug-resistant focal epilepsy, potentially offering a novel marker for its localization.

  3. Retrospective interviews reveal unawareness of weakness following reversible hemispheric suppression: An exploratory study using selective anesthesia for functional evaluation. International-journal Peer-reviewed

    Hiroaki Hosokawa, Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Marie Oyafuso, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Kuniyasu Niizuma, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　190　146-154　2025/07/05

    DOI： 10.1016/j.cortex.2025.06.015 　

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    Unawareness of weakness-defined as an explicit failure to recognize one's own limb paresis after brain damage-has long been considered predominantly linked to right-hemisphere dysfunction, yet its laterality remains controversial. We retrospectively analyzed 86 sessions of Selective Anesthesia for Functional Evaluation (SAFE) conducted in 53 patients with surgical epilepsy. SAFE involves delivering a short-acting anesthetic into a single cortical artery branch, resulting in reversible cortical suppression. Contralateral weakness was defined as a positive Barré sign in the upper limb, corresponding to a Manual Muscle Test score of <3. Following the anesthetic effect, patients were asked whether they had experienced any motor impairment. Explicit unawareness was probed using two standardized questions, followed by a limb-specific inquiry. Interviews were conducted in real-time during 28 infusions and repeated within 30 sec of motor recovery in the remaining 58 sessions. Unawareness occurred in 41 of 52 left-hemisphere infusions (78.8%) and in 26 of 34 right-hemisphere infusions (76.5%). Real-time and immediate post hoc ratings were concordant in 26 of 28 paired assessments (93%). Infusions into the M2-superior division were associated with higher rates of unawareness than those into the M2-inferior division (odds ratio = 2.3, 95% confidence interval: 1.1-5.1). Within this reversible perfusion-suppression model, the frequency of unawareness of weakness was hemispherically balanced, promoting a cautious re-evaluation of the presumed right-hemisphere dominance. SAFE provides a practical tool for isolating transient awareness deficits without structural injury and may help bridge pharmacological and lesion-based approaches to brain-behavior mapping.

  4. Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation. International-journal Peer-reviewed

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Journal of neurosurgery　1-8　2025/06/13

    DOI： 10.3171/2025.2.JNS242534 　

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    OBJECTIVE: The Wada test, an intracarotid amobarbital procedure, is the gold standard for the preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, because the anesthetic perfuses the language areas, infusion into the language-dominant hemisphere also causes aphasia. Although it has been noted that aphasia may affect verbal memory scores in the Wada test, the extent of the effects has not been verified. This study aimed to examine the extent to which verbal memory is affected by aphasia induced by selective anesthetization of the proximal middle cerebral artery (M1) area (which does not affect the hippocampus) in patients with drug-resistant epilepsy. METHODS: This single-center retrospective analysis included patients with drug-resistant epilepsy who underwent the Selective Anesthesia for Functional Evaluation (SAFE) as a preoperative evaluation between May 2018 and December 2023. SAFE includes cognitive tasks of equal difficulty administered before and immediately after anesthetic infusion. The preinfusion assessments confirmed the baseline, whereas the postinfusion assessments evaluated brain function under selective anesthesia. The patients were required to memorize 8 words and 8 pictures. After the anesthetic effects subsided, recognition tasks were performed for both words and pictures. The number of words and pictures successfully recognized were counted as verbal and visual memory scores, respectively. Memory scores were compared between the left and right M1 infusions. RESULTS: Of the 180 SAFE trials conducted during the study period, 38 trials (25 left and 13 right M1 infusions) in 29 patients with confirmed left language dominance and propofol infusion into the M1 were included. All left M1 infusions induced aphasia without causing significant disturbances in consciousness that could have interfered with task completion. The results indicated significantly lower verbal memory scores during left M1 infusions than during right M1 infusions, whereas the visual memory scores were comparable. CONCLUSIONS: The verbal memory score was significantly lower after infusion into the M1 of the language-dominant hemisphere than into the nondominant hemisphere, suggesting that aphasia during stimulus encoding may impair verbal memory. Thus, the Wada test with intracarotid anesthetic infusion may not accurately assess memory function due to aphasia. This study highlights the utility of SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with epilepsy.

  5. Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms). International-journal Peer-reviewed

    Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    NeuroImage　317　121316-121316　2025/06/07

    DOI： 10.1016/j.neuroimage.2025.121316 　

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    Reading engages complex neural networks integrating visual, phonological, and semantic information. The dual-stream model posits ventral and dorsal pathways for lexical and sublexical processing in the left hemisphere and is well-supported in alphabetic languages. However, its applicability to non-alphabetic scripts remains unclear. The Japanese writing system, comprising Kana (syllabograms) and Kanji (morphograms) with distinct orthographic, phonological, and semantic properties, provides a unique framework to investigate neural dissociation between phonological and orthographic-semantic processing. Previous studies suggest that Kanji relies on the ventral route for whole-word recognition and semantic processing, whereas Kana depends mainly on the dorsal route for phonological decoding via grapheme-to-phoneme conversion; however, their spatiotemporal dynamics remain unknown. Using high-gamma power analysis from electrocorticography recordings in 14 patients with epilepsy and subdural implants, we examined the spatiotemporal neural dynamics of Kana and Kanji reading. Participants completed a visual lexical decision task with Kana and Kanji words and pseudowords. Across 912 electrodes, differential high-gamma power analysis showed that Kanji activated bilateral occipitotemporal fusiform regions early (120-550 ms) and the left inferior temporal gyrus (150-240 ms). Conversely, Kana showed prolonged late activation (270-750 ms) in the left-lateralised superior temporal, supramarginal, and inferior frontal gyri, especially during pseudoword processing. These findings indicate that Kanji relies on bilateral ventral stream earlier, while Kana depends on the left dorsal stream, with slower processing reflecting the extra grapheme-to-phoneme conversion. This underscores the value of non-alphabetic languages in elucidating both universal and script-specific neural mechanisms, advancing a cross-linguistic understanding of the reading network.

  6. Visualization of functional and effective connectivity underlying auditory descriptive naming. International-journal Peer-reviewed

    Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa, Kazushi Ukishiro, Makoto Ishida, Kazuo Kakinuma, Shoko Ota, Yutaro Takayama, Keiya Iijima, Toshimune Kambara, Hidenori Endo, Kyoko Suzuki, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　175　2010729-2010729　2025/04/21

    DOI： 10.1016/j.clinph.2025.04.008 　

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    OBJECTIVE: We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions. METHODS: We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography. RESULTS: Hearing a wh-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with what, compared to where, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus. CONCLUSIONS: Visualization of directional neural interactions within white matter networks during overt naming is feasible. SIGNIFICANCE: Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.

  7. Adult‐onset epilepsy with startle‐induced seizure after febrile infection‐related epilepsy syndrome: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Yu Fujiwara, Takafumi Kubota, Maimi Ogawa, Makoto Ishida, Kazushi Ukishiro, Hirohiko Ono, Kimihiko Kaneko, Naoto Sugeno, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2025/04/15

    Publisher: Wiley

    DOI： 10.1002/epd2.70026 　

    ISSN： 1294-9361

    eISSN： 1950-6945

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    Abstract Startle‐induced seizure is a rare type of reflex seizure triggered by unexpected sensory stimuli that often occurs in children with early acquired cerebral lesions or brain malformations. We report a unique case of adult‐onset epilepsy with startle‐induced seizures. A 24‐year‐old woman had suffered high fever and focal to bilateral tonic–clonic seizures. A diagnosis of febrile infection‐related epilepsy syndrome (FIRES) was made based on the febrile infection occurring 7 days to 24 h before the onset of status epilepticus, which met all criteria for cryptogenic new‐onset refractory status epilepticus (NORSE) according to the cryptogenic NORSE score. Immunotherapy and several antiseizure medications resulted in transient resolution of the seizures. Four months later, she experienced startle‐induced seizures triggered by unexpected stimuli, such as auditory, visual, or unexpected events, and manifesting as initial tachycardia followed by right ear deafness, right hemifacial dysesthesia, eye deviation to the right, and tonic–clonic convulsions. Ictal electroencephalography revealed left temporal initial rhythmic delta activity, followed by rhythmic theta activity. The patient was diagnosed with startle epilepsy associated with FIRES and continued to receive anti‐seizure medications. Claustrum‐insular‐operculum lesions may have been the epileptic focus in this case, in contrast to previous cases of epilepsy with startle‐induced seizures originating in a frontoparietal network. This case indicates a new category of adult‐onset post‐FIRES epilepsy with startle‐induced seizures.

  8. Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandic epilepsy surgery. International-journal Peer-reviewed

    Atsuhiko Ninomiya, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Yoshiteru Shimoda, Kazutaka Jin, Mitsugu Uematsu, Shiho Sato, Shunji Mugikura, Hiroyoshi Suzuki, Hajime Miyata, Shingo Kayano, Nobukazu Nakasato, Hidenori Endo

    Journal of neurosurgery　1-13　2025/02/14

    DOI： 10.3171/2024.10.JNS24878 　

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    OBJECTIVE: Surgery for peri-rolandic epilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. METHODS: Sixteen patients with peri-rolandic epilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data of each case, the authors examined the surgically resected area on high-resolution 3D MR images and the high-intensity area on diffusion-weighted images, which were converted to voxel data. These voxel data were superimposed on a standard brain image for neuroimaging assessment. Postoperative motor deterioration of the orofacial region, upper limb, or lower limb was noted as no, transient, or permanent deterioration and analyzed in relation to the surgically resected area and subcortical damage. Univariate analysis of the clinical factors was conducted between cases with permanent upper- and/or lower-limb motor deterioration and those with no or transient deterioration. RESULTS: The mean follow-up period was 28 months. Ten patients (62.5%) achieved Engel class I. Fourteen patients (87.5%) experienced postoperative motor deteriorations in the following areas (no/transient/permanent): orofacial (11/5/0), upper limb (9/5/2), and lower limb (9/3/4). All cases with orofacial motor deterioration underwent cortical resection of the inferior third of the peri-rolandic cortex. Cortical resection of the precentral gyrus only, in contrast to both the precentral and postcentral gyri, was not associated with permanent upper- and/or lower-limb motor deterioration. Cortical resection involving the postcentral gyrus was significantly associated with permanent upper- and/or lower-limb motor deterioration in 4 cases (25.0%). Surgically related perforating artery injury caused ischemic subcortical damage, which was significantly associated with postoperative transient or permanent motor deterioration by extending to the corticospinal tract (CST). CONCLUSIONS: Postoperative motor deterioration for peri-rolandic epilepsy was related to both the resected cortex and ischemic subcortical damage. In peri-rolandic epilepsy, cortical resection of the precentral gyrus might not necessarily cause permanent upper- and/or lower-limb motor deterioration because of the functional reserve in other peri-rolandic areas outside the epileptic focus. On the other hand, cortical resection of the postcentral gyrus could cause permanent upper- and/or lower-limb motor deterioration because of injury to the vasculature, which is crucial for the descending motor pathway in the CST.

  9. Complete Corpus Callosotomy Brings Worthwhile Seizure Reduction in Both Pediatric and Adult Patients. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Neurosurgery　96　(2)　410-415　2025/02/01

    DOI： 10.1227/neu.0000000000003092 　

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    BACKGROUND AND OBJECTIVES: The influence of the age at which complete corpus callosotomy (CC) surgery is performed on seizure outcomes remains unclear. This study aimed to evaluate the age-dependent aspects of long-term seizure outcomes after complete CC. METHODS: We reviewed 41 patients who underwent one-stage complete CC. Seizure outcomes were analyzed for age at epilepsy onset and at complete CC, focal MRI abnormality, and etiology. RESULTS: The median age was 7 months at epilepsy onset and 93 months at complete CC. The median follow-up duration was 67 months. Sixteen patients had focal MRI lesions and 4 had only general atrophy. Etiology was identified in 20 patients. For overall seizure outcomes (N = 41), complete seizure freedom was achieved in 5 patients, excellent seizure reduction (>80%) in 11, good (50%-80%) in 5, and poor (<50%) in 20. Freedom was correlated with younger age at complete CC and unknown etiology (P ≤ .05). Freedom was only achieved in patients aged younger than 7 years. Worthwhile (≥50%, freedom, excellent, and good) and not worthwhile (<50%, poor) overall seizure reduction showed no statistical difference in age at complete CC. No related factor was found for worthwhile overall seizure reduction. For drop attack outcomes (N = 31), freedom was achieved in 22 cases, excellent in 5, and poor in 4. Freedom was correlated with younger age at complete CC (P < .05) although freedom was achieved in 4 of 7 patients older than 20 years. Age at complete CC showed no statistical difference between worthwhile (≥50%) and not worthwhile (<50%) drop attack reduction. Worthwhile drop attack reduction was correlated with unknown etiology (P < .05). Complications were mild and transient. CONCLUSION: Complete CC is an excellent surgical option based on favorable seizure outcomes and acceptable complications in our present study.

  10. Verbal Memory Localized in Non-language-dominant Hemisphere: Atypical Lateralization Revealed by Material-specific Memory Evaluation Using Super-selective Wada Test. Peer-reviewed

    Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    NMC case report journal　12　65-71　2025

    DOI： 10.2176/jns-nmc.2024-0217 　

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    Hippocampectomy is effective for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis. However, multiple studies have reported high risks associated with hippocampectomy in patients with mesial temporal lobe epilepsy without hippocampal sclerosis on magnetic resonance imaging and in those with preserved memory function. Verbal memory and language functions are believed to coexist in the same hemisphere. We present a case of left mesial temporal lobe epilepsy with atypical memory function lateralization revealed by super-selective infusion of propofol to the intracranial artery (super-selective Wada test). A 24-year-old right-handed man with drug-resistant focal impaired awareness seizures was diagnosed with left mesial temporal lobe epilepsy without hippocampal sclerosis, but he showed preserved verbal intelligence quotient and memory, suggesting a high risk of severe memory decline after hippocampectomy. We performed super-selective Wada test to the posterior cerebral artery to assess the lateralization of verbal and visual memory separately, and to the middle cerebral artery to assess language function. The results revealed right-sided dominance for both verbal and visual memory, although the language was left-dominant. Hippocampectomy was performed and resulted in freedom from seizures. Memory assessments 1 year postoperatively showed no decline in all subtests. In patients with drug-resistant epilepsy exhibiting atypical neuropsychological profiles, the memory-dominant, and language-dominant hemispheres may not align; detailed evaluations of function lateralization are necessary for tailored treatment.

  11. Recurring utterances induced by local anesthetic administration to the left frontal lobe. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Makoto Ishida, Kazushi Ukishiro, Kazutaka Jin, Shingo Kayano, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Minoru Matsuda, Kyoko Suzuki

    Cortex; a journal devoted to the study of the nervous system and behavior　183　15-20　2024/11/19

    DOI： 10.1016/j.cortex.2024.10.019 　

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    Recurring utterances (RUs) are a distinct language symptom observed in severe aphasia, known to be associated with global or Broca's aphasia, though their neural basis remains unclear. We present a case of RU induced by selective left frontal suppression using a novel technique named the super-selective Wada test (ssWada), which involves temporary anesthetization of specific brain regions through super-selective catheterization of cerebral arteries. This method allows for precise simulation of localized brain dysfunction. We applied this technique on a 49-year-old right-handed man with drug-resistant epilepsy as a preoperative examination. Propofol administration to the superior branch of the left middle cerebral artery (MCA), supplying the pars triangularis, pars opercularis, middle frontal gyrus, and part of the precentral gyrus, induced Broca's aphasia with RUs. The RU content was the phrase uttered at anesthesia administration. Notably, the anesthetic did not affect the temporal language area or basal ganglia. The patient showed minimal awareness of his abnormal speech despite preserved receptive language function and memory, aligning with previous observations of anosognosia in patients with RU. Contrastingly, anesthetic infusion into the inferior branch of the left MCA resulted in mixed aphasia, while right MCA infusion induced no language impairments. This case demonstrates that RUs can arise without deficits in the posterior language area or basal ganglia. It illustrates the potential of ssWada in investigating neural substrates of neuropsychological symptoms through temporary, localized brain disruption. This approach offers novel insights into brain-behavior relationships in language processing and cognition.

  12. Individual and relational factors related to disclosure of epilepsy in the workplace Peer-reviewed

    Maimi Ogawa, Mayu Fujikawa, Katsuya Tasaki, Kazushi Ukishiro, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

    Epilepsy &amp; Behavior　160　110079-110079　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.yebeh.2024.110079 　

    ISSN： 1525-5050

  13. Spatiotemporal neural dynamics in kanji vs. kana reading: An electroencephalography(ECoG) study(タイトル和訳中)

    Katsuse Kazuto, Kakinuma Kazuo, Osawa Shinichiro, Ota Shoko, Kikuchi Hana, Kawamura Ai, Ukishiro Kazushi, Tanji Kazuyo, Iseki Chifumi, Kanno Shigenori, Hamada Masashi, Toda Tatsushi, Endo Hidenori, Nakasato Nobukazu, Suzuki Kyoko

    臨床神経学　64　(Suppl.)　S237-S237　2024/10

    Publisher: (一社)日本神経学会

    ISSN： 0009-918X

    eISSN： 1882-0654

  14. Super-selective injection of propofol into the intracranial arteries enables Patient's self-evaluation of expected neurological deficit. International-journal Peer-reviewed

    Shin-Ichiro Osawa, Kyoko Suzuki, Kazushi Ukishiro, Kazuo Kakinuma, Makoto Ishida, Kuniyasu Niizuma, Yoshiteru Shimoda, Hana Kikuchi, Ryuzaburo Kochi, Kazutaka Jin, Yasushi Matsumoto, Mitsugu Uematsu, Nobukazu Nakasato, Hidenori Endo, Teiji Tominaga

    Cortex; a journal devoted to the study of the nervous system and behavior　176　209-220　2024/05/19

    DOI： 10.1016/j.cortex.2024.04.016 　

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    INTRODUCTION: It is hard to realize the extent of the expected postoperative neurological deficit for patients themselves. The provision of appropriate information can contribute not only to examining surgical indications but also to filling the gap between patient and expert expectations. We hypothesized that propofol infusion into the intracranial arteries (ssWada) could induce focal neurological symptoms with preserved wakefulness, enabling the patients to evaluate the postsurgical risk subjectively. METHODS: Presurgical evaluation using ssWada was performed in 28 patients with drug-resistant epilepsy. Based on anatomical knowledge, propofol was super-selectively infused into the intracranial arteries including the M1, M2, and M3 segments of the middle cerebral artery (MCA), A2 segment of the anterior cerebral artery, and P2 segment of the posterior cerebral artery to evaluate the neurological and cognitive symptoms. We retrospectively analyzed a total of 107 infusion trials, including their target vessels, and elicited symptoms of motor weakness, sensory disturbance, language, unilateral hemispatial neglect (UHN), and hemianopsia. We evaluated preserved wakefulness which enabled subjective evaluations of the symptoms and comparison of the subjective experience to the objective findings, besides adverse effects during the procedure. RESULTS: Preserved wakefulness was found in 97.2% of all trials. Changes in neurological symptoms were positively evaluated for motor weakness in 51.4%, sensory disturbance in 5.6%, language in 48.6%, UHN in 22.4%, and hemianopsia in 32.7%. Six trials elicited seizures. Multivariate analysis showed significant correlations between symptom and infusion site of language and left side, language and MCA branches, motor weakness and A2 or M2 superior division, and hemianopsia and P2. Transient adverse effect was observed in 8 cases with 12 infusion trials (11.2 %). CONCLUSION: The ssWada could elicit focal neurological symptoms with preserved wakefulness. The methodology enables specific evaluation of risk for cortical resection and subjective evaluation of the expected outcome by the patients.

  15. Remission of startle epilepsy provoked by acoustic stimuli following complete callosotomy: A case study. International-journal Peer-reviewed

    Kazushi Ukishiro, Shin-Ichiro Osawa, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

    Epileptic disorders : international epilepsy journal with videotape　2024/05/07

    DOI： 10.1002/epd2.20238 　

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    Herein, we present the case of a 21-year-old man with a history of generalized tonic seizures since the age of 4 years. These seizures occurred either spontaneously or could be provoked by auditory stimuli such as the sounds of a vacuum cleaner or an electric shaver. Despite trials with 10 different anti-seizure medications, his seizures remained refractory. Interictal electroencephalography (EEG) revealed generalized epileptiform activity, whereas ictal EEG showed a generalized attenuation pattern. Magnetic resonance imaging revealed extensive chronic infarctions, predominantly in the bilateral cerebral watershed areas. At the age of 17, the patient underwent a one-stage complete callosotomy, which only achieved remission of auditory-provoked seizures. Based on this experience and published reports, we propose that the posterior corpus callosum, particularly the isthmus and anterior splenium, may be involved in seizures caused by unexpected sound stimuli.

  16. “Caterpillar sign” in corpus callosum associated with curvilinear pericallosal lipoma in MRI: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Shiho Sato, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Kazutaka Jin, Shunji Mugikura, Masashi Aoki, Nobukazu Nakasato

    Radiology Case Reports　19　(5)　2058-2061　2024/05

    DOI： 10.1016/j.radcr.2024.02.058 　

    eISSN： 1930-0433

  17. Genetic generalized epilepsy with catecholaminergic polymorphic ventricular tachycardia complicated by ryanodine receptor 2 variant: A case report Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Takeshi Aiba, Shin Takahashi, Hironobu Ueda, Takafumi Kubota, Temma Soga, Kazushi Ukishiro, Masashi Aoki, Nobukazu Nakasato

    Seizure: European Journal of Epilepsy　117　284-287　2024/04

    Publisher: Elsevier BV

    DOI： 10.1016/j.seizure.2024.04.003 　

    ISSN： 1059-1311

  18. Assessment of language lateralization in epilepsy patients using the super-selective Wada test. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Kazuto Katsuse, Hiroaki Hosokawa, Kazushi Ukishiro, Kazutaka Jin, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

    Acta neurochirurgica　166　(1)　77-77　2024/02/10

    DOI： 10.1007/s00701-024-05957-8 　

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    BACKGROUND: The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10-30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA). METHODS: We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial. RESULTS: The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance. CONCLUSIONS: The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.

  19. Bilateral and asymmetrical localization of language function identified by the superselective infusion of propofol in an epilepsy patient with a mild malformation of cortical development: illustrative case. International-journal Peer-reviewed

    Mayuko Otomo, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Hiroyoshi Suzuki, Kuniyasu Niizuma, Norio Narita, Nobukazu Nakasato, Teiji Tominaga

    Journal of neurosurgery. Case lessons　6　(26)　2023/12/25

    DOI： 10.3171/CASE23451 　

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    BACKGROUND: Atypical localization of language function can result in unexpected postsurgical deficits after cortical resection, but it is difficult to predict the risk in the presurgical evaluation. The authors experienced a rare case of the bilateral and independent existence of different components of language function identified by segmented evaluation of anatomical anterior and posterior language areas using the superselective infusion of propofol. OBSERVATIONS: A 32-year-old right-handed female presented with drug-resistant epilepsy. Comprehensive epilepsy evaluation suggested that the epileptic foci involved the whole left frontal lobe but provided less evidence of structural abnormality. To estimate the extent of functional deterioration likely to be caused by an extended left frontal lobectomy, the authors evaluated segmented cortical function in the ipsi- and contralateral hemispheres by the superselective infusion of propofol into the branches of the intracranial artery. The results revealed bilateral and asymmetrical localization of language function because the patient presented with different components of aphasia in each hemisphere. Based on the authors' assessment of her functional tolerance, an extended left frontal lobectomy was performed and resulted in neurological deficits within the anticipated range. LESSONS: An accurate understanding of the correlations between vascular and functional anatomy and the highly specific evaluation of language function provides more advanced presurgical assessment, allowing more tailored planning of cortical resection.

  20. Referral odyssey plot to visualize causes of surgical delay in mesial temporal lobe epilepsy with hippocampal sclerosis. International-journal Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Makoto Ishida, Temma Soga, Kazushi Ukishiro, Shin-Ichiro Osawa, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

    Epilepsy & behavior : E&B　147　109434-109434　2023/09/14

    DOI： 10.1016/j.yebeh.2023.109434 　

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    The "odyssey plot" was used to visualize referral delays in epilepsy surgery. Participants were 36 patients (19 males; 13-67 years, median 27 years) with mesial temporal lobe epilepsy with hippocampal sclerosis (HS) who underwent resection surgery. The "referral odyssey plot" included five clinical episodes: seizure onset (T1), first visits to a non-epileptologist (T2) and to an epileptologist (T3), first admission to our epilepsy monitoring unit (EMU) (T4), and resection surgery (T5). For each patient, we identified the first seizure type: the physician who first diagnosed focal aware seizure (FAS), focal impaired awareness seizure (FIAS), focal to bilateral tonic-clonic seizure (FBTCS), and radiologically suspected HS. Within the overall delay (T1-T5, median 18 years; interquartile range [IQR] 14), non-epileptologist's delay (T2-T3, 11.5 years; IQR 12.25) was far (p < 0.0001) longer than patient's (T1-T2, 0 year; IQR 2.25), epileptologist's (T3-T4, 1 year; IQR 4), or after-EMU delay (T4-T5, 1 year; IQR 1). FAS onset cases had significantly longer T1-T2 (N = 5, median 7 years; IQR 6) than FIAS (N = 22, 0 year; IQR 1, p < 0.005) or FBTCS onset cases (N = 9, 0 year; IQR 0, p < 0.001). FAS was correctly diagnosed first by non-epileptologists in 17.9%, by out-patient epileptologists in 35.7%, and at the EMU in 46.4%. FIAS was correctly diagnosed first by non-epileptologists in 94.4% and by out-patient epileptologists in 5.6%. Non-epileptologists diagnosed FBTCS in all cases. HS was diagnosed by non-epileptologists in 13.9%, by out-patient epileptologists in 47.2%, and at the EMU in 38.9%. Early referral to epileptologists is most critical for early surgery. Early utilization of the EMU is highly recommended because FAS is often overlooked by outpatient epileptologists. The odyssey plot will be useful to improve the healthcare system for other types of epilepsy.

  21. Temporomandibular joint dislocation during epileptic seizures in the epilepsy monitoring unit: A case report Peer-reviewed

    Takafumi Kubota, Kazutaka Jin, Keigo Honoki, Temma Soga, Kazushi Ukishiro, Yosuke Kakisaka, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/09

    Publisher: Wiley

    DOI： 10.1002/epd2.20158 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  22. Dynamic electro‐clinical changes corresponding to immediate recovery after glucose administration from insulinoma‐induced hypoglycemia: report of two cases Peer-reviewed

    Kazutoshi Konomatsu, Yosuke Kakisaka, Kazutaka Jin, Kazushi Ukishiro, Ayumi Sakata, Takafumi Shimogawa, Takato Morioka, Takafumi Kubota, Temma Soga, Masashi Aoki, Nobukazu Nakasato

    Epileptic Disorders　2023/08/26

    Publisher: Wiley

    DOI： 10.1002/epd2.20155 　

    ISSN： 1294-9361

    eISSN： 1950-6945

  23. Causal involvement of medial inferior frontal gyrus of non-dominant hemisphere in higher order auditory perception: A single case study. International-journal Peer-reviewed

    Shin-Ichiro Osawa, Kyoko Suzuki, Eishi Asano, Kazushi Ukishiro, Dai Agari, Kazuo Kakinuma, Ryuzaburo Kochi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

    Cortex; a journal devoted to the study of the nervous system and behavior　163　57-65　2023/03/29

    DOI： 10.1016/j.cortex.2023.02.007 　

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    The medial side of the operculum is invisible from the lateral surface of cerebral cortex, and its functions remain largely unexplored using direct evidence. Non-invasive and invasive studies have proved functions on peri-sylvian area including the inferior frontal gyrus (IFG) and superior temporal gyrus within the language-dominant hemisphere for semantic processing during verbal communication. However, within the non-dominant hemisphere, there was less evidence of its functions except for pitch or prosody processing. Here we add direct evidence for the functions of the non-dominant hemisphere, the causal involvement of the medial IFG for subjective auditory perception, which is affected by the context of the condition, regarded as a contribution in higher order auditory perception. The phenomenon was clearly distinguished from absolute and invariant pitch perception which is regarded as lower order auditory perception. Electrical stimulation of the medial surface of pars triangularis of IFG in non-dominant hemisphere via depth electrode in an epilepsy patient rapidly and reproducibly elicited perception of pitch changes of auditory input. Pitches were perceived as either higher or lower than those given without stimulation and there was no selectivity for sound type. The patient perceived sounds as higher when she had greater control over the situation when her eyes were open and there were self-cues, and as lower when her eyes were closed and there were investigator-cues. Time-frequency analysis of electrocorticography signals during auditory naming demonstrated medial IFG activation, characterized by low-gamma band augmentation during her own vocal response. The overall evidence provides a neural substrate for altered perception of other vocal tones according to the condition context.

  24. 扁桃体肥大を伴う側頭葉てんかん患者における発作間欠期の神経磁場スパイクのECD配向(ECD direction of interictal neuromagnetic spikes in patients with temporal lobe epilepsy with amygdala enlargement)

    Konomatsu Kazutoshi, Jin Kazutaka, Ishida Makoto, Sato Shiho, Morishita Yohei, Soga Temma, Ukishiro Kazushi, Kakisaka Yosuke, Kanno Akitake, Mugikura Shunji, Aoki Masashi, Nakasato Nobukazu

    日本生体磁気学会誌　36　(1)　158-159　2023

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  25. Ictal chest discomfort in a patient with temporal lobe seizures and amygdala enlargement Peer-reviewed

    Hisashi Ohseto, Temma Soga, Yosuke Kakisaka, Kazutaka Jin, Kazushi Ukishiro, Kazutoshi Konomatsu, Takafumi Kubota, Juichi Fujimori, Nobukazu Nakasato

    Epilepsy &amp; Behavior Reports　100578-100578　2022/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.ebr.2022.100578 　

    ISSN： 2589-9864

  26. Determination of language areas in patients with epilepsy using the super-selective Wada test. International-journal Peer-reviewed

    Kazuo Kakinuma, Shin-Ichiro Osawa, Hiroaki Hosokawa, Marie Oyafuso, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Takafumi Sato, Mika Sakamoto, Kuniyasu Niizuma, Teiji Tominaga, Nobukazu Nakasato, Kyoko Suzuki

    IBRO neuroscience reports　13　156-163　2022/12

    DOI： 10.1016/j.ibneur.2022.08.002 　

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    The Wada test is the gold standard for determining language-dominant hemisphere. However, the precise determination of language areas in each patient requires more invasive methods, such as electrocortical stimulation. Some studies have reported the use of anesthetic injection into selective cerebral arteries to predict postoperative function. To assess the function of the anterior and posterior language areas separately, we developed an advanced test named the "super-selective Wada test" (ssWada). The ssWada procedure is as follows: an endovascular neurosurgeon identifies the arterial branches of the middle cerebral artery (MCA) perfusing the anterior language area of the inferior frontal gyrus and the posterior language area of the posterior part of the superior temporal gyrus using angiography. Behavioral neurologists assess language symptoms before and after propofol administration using a microcatheter tip in the selected arterial branch. From 30 serial patients with epilepsy who underwent ssWada test at Tohoku University Hospital, we retrospectively reviewed patients in whom multiple areas in the bilateral MCA region was examined. Eight cases were identified in this study. All eight cases had been considered for resection of the area overlapping the classical language area. Three of the eight cases were left-dominant, and the within-hemisphere distribution was also considered typical. One case was determined to be left-dominant but atypical in the intra-hemispheric functional distribution. Two cases were right-dominant, and the intra-hemispheric functional distribution was considered a mirror image of the typical pattern. The remaining two cases were considered atypical, not only in terms of bilateral language function, but also in terms of anterior-posterior functional distribution. This case series demonstrates the potential utility of ssWada in revealing separate function of the anterior and posterior language areas. The ssWada allows simulation of local surgical brain resection and detailed investigation of language function, which potentially contributes to planning the resection area. Although indications for ssWada are quite limited, it could play a complementary role to noninvasive testing because it provides information related to resection using a different approach.

  27. A Super-selective Wada Test Successfully Detected an Artery That Supplied Broca's Area in a Case of Left Frontal Lobe Glioblastoma: Technical Case Report. Peer-reviewed

    Shota Yamashita, Ryuta Saito, Shin-Ichiro Osawa, Kuniyasu Niizuma, Kazushi Ukishiro, Masayuki Kanamori, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga

    Neurologia medico-chirurgica　61　(11)　661-666　2021/08/26

    DOI： 10.2176/nmc.tn.2021-0054 　

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    In cases of malignant gliomas located at language eloquent area, it is often difficult to preoperatively detect those area with functional MRI. Awake surgery is often used to spare the language eloquent area during surgery for such tumors; it is not available for a patient whose intracranial pressure is elevated due to the malignant tumor. The Wada test involves infusing anesthetic agents into the internal carotid artery to determine language dominancy before surgery for epilepsy or brain tumor. The super-selective Wada test is a technique to detect more detailed functional localization by infusing anesthetics into far distal middle cerebral artery branches. We present a 37-year-old man suffering from a left frontal lobe glioblastoma, in whom detection of an artery supplying Broca's area was attempted by a super-selective Wada test. The super-selective Wada test successfully detected the branch of middle cerebral artery supplying Broca's area. Total resection of the contrast-enhancing area was achieved without damaging the artery supplying Broca's area without any neurological sequelae. This is the first report describing the usefulness of the super-selective Wada test in glioblastoma treatment. Our findings suggest that the super-selective Wada test is a powerful and useful means to distinguish the artery that supplies the language area from the tumor feeding artery in cases of tumors in the language eloquent area.

  28. Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners. International-journal Peer-reviewed

    Hirotaka Iwaki, Masaki Sonoda, Shin-Ichiro Osawa, Brian H Silverstein, Takumi Mitsuhashi, Kazushi Ukishiro, Yutaro Takayama, Toshimune Kambara, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

    Scientific reports　11　(1)　5257-5257　2021/03/04

    DOI： 10.1038/s41598-021-84610-1 　

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    The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.

  29. Epilepsy in Five Long-term Survivors of Pineal Region Tumors. Peer-reviewed

    Yutaro Takayama, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Kazushi Ukishiro, Yosuke Kakisaka, Teiji Tominaga, Tetsuya Yamamoto, Nobukazu Nakasato

    NMC case report journal　8　(1)　773-780　2021

    DOI： 10.2176/nmccrj.cr.2021-0093 　

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    Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2-22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.

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Misc. 87

  1. 症例報告執筆教育をいかに普及させるか-まず「支援され」次に「支援する」二つの立場を経験して感じたことから- Peer-reviewed

    池之内初, 柿坂庸介, 浮城一司

    医学教育　56　(1)　36-37　2025/02

  2. 効果的な高校生の進路支援を心理学的理論から考える-医学部模擬講義を含む高校生の大学訪問事業への異なる立場からの参画経験を通じて-. Peer-reviewed

    東濵菜々子 , 柿坂庸介 , 小川舞美 , 浮城一司

    医学教育　56　44-45　2025/02

  3. Diagnostic method for localizing function by Neuro-logical Evaluation Under Regional Anesthesia (NEURA-NET)

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

    てんかん研究　42　(3)　2025

    ISSN： 0912-0890

  4. 超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

    菊地花, 大沢伸一郎, 柿沼一雄, 太田祥子, 勝瀬一登, 勝瀬一登, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

    てんかん研究　42　(3)　2025

    ISSN： 0912-0890

  5. 10-10電極配置法に則った追加脳波電極が発作時脳波変化の検出に有用であった一例

    坂本美佳, 神一敬, 此松和俊, 此松和俊, 大沢伸一郎, 浮城一司, 浅黄優, 三木俊, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　12th　2025

  6. 左右側頭葉てんかんにおけるセルフスティグマの関連要因の差異

    小川舞美, 藤川真由, 浮城一司, 此松和俊, 此松和俊, 久保田隆文, 久保田隆文, 大友風佳, 高橋健人, 柿坂庸介, 神一敬, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　12th　2025

  7. 後大脳動脈で灌流される海馬周囲構造への超選択的麻酔は記憶機能のモダリティ別評価を可能にする

    大沢 伸一郎, 鈴木 匡子, 柿沼 一雄, 勝瀬 一登, 菊地 花, 浮城 一司, 石田 誠, 下田 由輝, 新妻 邦泰, 神 一敬, 中里 信和, 遠藤 英徳

    てんかん研究　42　(2)　514-514　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  8. 超選択的Wadaテストによる脳領域別の言語機能推定

    柿沼 一雄, 大沢 伸一郎, 勝瀬 一登, 菊地 花, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　42　(2)　521-521　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  9. Wadaテストにおける記憶スコアは言語機能領域への薬剤注入で低下しうる

    菊地 花, 大沢 伸一郎, 柿沼 一雄, 勝瀬 一登, 太田 祥子, 川村 藍, 劉 軍艶, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    てんかん研究　42　(2)　522-522　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  10. 深層学習を用いた単チャネル脳波のdensity spectral arrayによるてんかん発作と心因性非てんかん発作の鑑別

    此松 和俊, 柏田 祐樹, 久保田 隆文, 神 一敬, 高橋 健人, 黒田 直生人, 浮城 一司, 柿坂 庸介, 青木 正志, 中里 信和

    てんかん研究　42　(2)　584-584　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  11. 小児期に発症した焦点てんかん患者の成人科への移行時期と就労状況

    小川 舞美, 神 一敬, 浮城 一司, 藤川 真由, 大友 風佳, 高橋 健人, 此松 和俊, 久保田 隆文, 柿坂 庸介, 中里 信和

    てんかん研究　42　(2)　610-610　2024/09

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  12. 超選択的Wadaテストで言語優位半球と言語性記銘力の側方性不一致が示された側頭葉てんかんの1例

    柿沼 一雄, 大沢 伸一郎, 菊地 花, 太田 祥子, 勝瀬 一登, 土屋 真理夫, 浮城 一司, 神 一敬, 遠藤 英徳, 中里 信和, 鈴木 匡子

    神経心理学　40　(3)　231-241　2024/09

    Publisher: 日本神経心理学会

    ISSN： 0911-1085

    eISSN： 2189-9401

  13. 小学校教諭免許を有する医学生から見た、医学教育における論文作成等の”探究的学修”活動に対する考察 Peer-reviewed

    木村颯介, 柿坂庸介, 浮城一司

    医学教育　55　(4)　350-351　2024/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  14. 医学専門教育開始前の学修者に焦点を当てた論文執筆教育の試み-医学教育誌に掲載された論考を活用して- Peer-reviewed

    柿坂庸介, 佐々木拓也, 浮城一司

    医学教育　55　(3)　268-269　2024/06

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  15. 症例報告の添削過程を録画し、著者と共有する教育的取り組み Peer-reviewed

    柿坂庸介, 多田寛, 森下葵, 浮城一司, 大田千晴

    医学教育　55　(3)　264-265　2024/06

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  16. 超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

    菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  17. 超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

    柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

    高次脳機能研究　44　(1)　2024

    ISSN： 1348-4818

  18. 麻酔薬の頭蓋内選択的動注と認知神経学的評価を融合した任意脳領域の機能局在診断法

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 中里信和, 遠藤英徳

    日本脳神経血管内治療学会学術集会抄録集(Web)　40th　2024

    ISSN： 2759-6907

  19. 左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

    高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

    臨床神経生理学(Web)　52　(5)　2024

    ISSN： 2188-031X

  20. 焦点および全般てんかんではどの睡眠段階で発作間欠時てんかん放電がみられるか?

    板橋泉, 浅黄優, 神一敬, 浮城一司, 三木俊, 中里信和, 中里信和

    臨床神経生理学(Web)　52　(5)　2024

    ISSN： 2188-031X

  21. 強直間代発作がてんかんセルフスティグマに与える影響

    小川舞美, 藤川真由, 浮城一司, 此松和俊, 此松和俊, 久保田隆文, 久保田隆文, 柿坂庸介, 神一敬, 中里信和

    全国てんかんセンター協議会総会プログラム・抄録集　11th　2024

  22. Achievement and Chanllenges in China's Standardized Residency Training System Peer-reviewed

    YU Chun, Ukishiro K, Kakisaka Y, Nakasato N

    2024

  23. 後大脳動脈への超選択的麻酔薬注入による記憶機能のカテゴリ別評価

    大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 菊地花, 浮城一司, 石田誠, 新妻邦泰, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

    日本ヒト脳機能マッピング学会プログラム・抄録集　26th　2024

  24. Verification for safety and efficacy of hydrogel-based organic electrode by physician-initiated clinical trial

    大沢伸一郎, 新妻邦泰, 中川敦寛, 新妻邦泰, 中川敦寛, 浮城一司, 下田由輝, 神一敬, 植松貢, 岩崎真樹, 西澤松彦, 中里信和, 冨永悌二, 遠藤英徳

    日本てんかん外科学会プログラム・抄録集　47th　2024

  25. Association between postoperative neuroimaging and motor dysfunction in peri-rolandic epilepsy after focal cortical resection

    二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 下田由輝, 鈴木博義, 宮田元, 神一敬, 植松貢, 中里信和, 遠藤英徳

    日本てんかん外科学会プログラム・抄録集　47th　2024

  26. Efficacy of complete callosotomy in a case of sound-induced generalized tonic seizures

    浮城一司, 大沢伸一郎, 柿坂庸介, 神一敬, 冨永悌二, 遠藤英徳, 中里信和

    日本てんかん外科学会プログラム・抄録集　47th　2024

  27. 中大脳動脈上行枝へのプロポフォール注入によって生じた再帰性発話

    柿沼一雄, 大沢伸一郎, 浮城一司, 菅野彰剛, 神一敬, 石田誠, 冨永悌二, 中里信和, 松田実, 鈴木匡子

    日本神経心理学会学術集会プログラム予稿集　47th　2023

  28. Relationship between surgical outcome and ictal heart rate increase in MRI-negative temporal lobe epilepsy

    曽我天馬, 曽我天馬, 神一敬, 柿坂庸介, 浮城一司, 此松和俊, 此松和俊, 久保田隆文, 久保田隆文, 大沢伸一郎, 岩崎真樹, 鈴木博義, 青木正志, 中里信和

    てんかん研究　41　(2)　2023

    ISSN： 0912-0890

  29. Super-selective injection of propofol into the intracranial arteries enables patient’s self-evaluation of expected neurological deficit after focal cortical resection

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 石田誠, 新妻邦泰, 新妻邦泰, 神一敬, 植松貢, 中里信和, 遠藤英徳

    てんかん研究　41　(2)　2023

    ISSN： 0912-0890

  30. 混乱するlow-grade epilepsy-associated neuroepithelial tumors(LEAT)の概念 切除外科の視点からLEAT概念を考える

    大沢 伸一郎, 浮城 一司, 下田 由輝, 鈴木 匡子, 神 一敬, 中里 信和, 冨永 悌二

    てんかん研究　40　(2)　282-283　2022/08

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  31. 限局性皮質異形成に伴う難治性てんかんに対し弁蓋部皮質を含む焦点切除術を行った1例

    宇根岡 紗希, 植松 貢, 西條 直也, 相原 悠, 渋谷 守栄, 宮副 貴光, 堅田 有宇, 及川 善嗣, 植松 有里佳, 浮城 一司, 大沢 伸一郎, 中里 信和, 冨永 悌二, 呉 繁夫

    脳と発達　54　(4)　286-286　2022/07

    Publisher: (一社)日本小児神経学会

    ISSN： 0029-0831

    eISSN： 1884-7668

  32. 疾患別の脳波 内側側頭葉てんかん

    浮城一司, 大沢伸一郎

    Clinical Neuroscience　2022/04

  33. 超選択的Wada Testにおける片麻痺に対する病態失認の検討

    細川 大瑛, 大沢 伸一郎, 柿沼 一雄, 太田 祥子, 親富祖 まりえ, 浮城 一司, 石田 誠, 神 一敬, 中里 信和, 新妻 邦泰, 冨永 悌二, 鈴木 匡子

    高次脳機能研究　42　(1)　71-72　2022/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  34. 言語症状に対する内観と失語型との対応 超選択的Wadaテストによる検討

    柿沼 一雄, 大沢 伸一郎, 細川 大瑛, 親富祖 まりえ, 太田 祥子, 浮城 一司, 石田 誠, 神 一敬, 中里 信和, 新妻 邦泰, 冨永 悌二, 鈴木 匡子

    高次脳機能研究　42　(1)　97-97　2022/03

    Publisher: (一社)日本高次脳機能障害学会

    ISSN： 1348-4818

    eISSN： 1880-6554

  35. Correlation between genotype and neuroimaging in low-grade epilepsy-associated neuroepithelial tumors

    飯島圭哉, 佐藤典子, 木村有喜男, 宮田元, 鈴木博義, 後藤雄一, 村山久美子, 木村唯子, 浮城一司, 吉富宗健, 金子裕, 岩崎真樹

    てんかん研究　40　(2)　2022

    ISSN： 0912-0890

  36. Epilepsy surgeon, the ambiguous, and myself

    浮城一司, 浮城一司

    てんかん研究　40　(2)　2022

    ISSN： 0912-0890

  37. Utility of AI-based magnetoencephalography analysis in a case of frontal lobe epilepsy

    菅野彰剛, 菅野彰剛, 大沢伸一郎, 神一敬, 柿坂庸介, 石田誠, 石田誠, 浮城一司, 曽我天馬, 此松和俊, 植松貢, 中田乙一, 長谷川史裕, 平田雅之, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　45th　2022

  38. Magnetoencephalography for the preoperative diagnosis of insulo-opercular epilepsy: report of 2 cases

    石田誠, 大沢伸一郎, 菅野彰剛, 柿坂庸介, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本てんかん外科学会プログラム・抄録集　45th　2022

  39. 麻酔薬の超選択的頭蓋内動脈による神経症状誘発は脳実質切除後の機能転帰を予測する

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 新妻 邦泰, 下田 由輝, 神 一敬, 中里 信和, 冨永 悌二

    脳血管内治療　6　(Suppl.)　S337-S337　2021/11

    Publisher: (NPO)日本脳神経血管内治療学会

    ISSN： 2423-9119

    eISSN： 2424-1709

  40. 低血糖発作からの急速な改善をビデオ脳波モニタリングで捉えたインスリノーマの1例

    此松 和俊, 柿坂 康介, 久保田 隆文, 曽我 天馬, 浮城 一司, 神 一敬, 中里 信和

    臨床神経生理学　49　(5)　400-400　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  41. 頭蓋内動脈への超選択的麻酔薬注入による詳細な神経症状評価と手術適応への寄与

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 新妻 邦泰, 下田 由輝, 神 一敬, 中里 信和, 冨永 悌二

    臨床神経生理学　49　(5)　449-449　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  42. C-NORSE後てんかん患者3例の脳波・脳磁図所見の特徴

    久保田 隆文, 神 一敬, 曽我 天馬, 浮城 一司, 石田 誠, 菅野 彰剛, 柿坂 庸介, 青木 正志, 中里 信和

    臨床神経生理学　49　(5)　419-419　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  43. てんかん脳磁図:当院のベスト・オブ・ザ・ベスト 脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

    石田 誠, 神 一敬, 菅野 彰剛, 大沢 伸一郎, 柿坂 庸介, 浮城 一司, 冨永 悌二, 中里 信和

    臨床神経生理学　49　(5)　350-350　2021/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  44. 成人期に長時間ビデオ脳波モニタリング検査を行った環状20番染色体症候群の2例

    曽我天馬, 曽我天馬, 神一敬, 柿坂庸介, 浮城一司, 伊澤理香子, 青木正志, 中里信和

    臨床神経生理学(Web)　49　(5)　2021

    ISSN： 2188-031X

  45. Provocation test by super-selective infusion of propofol predicts post-surgical functional outcome.

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

    脳血管内治療(Web)　6　(Supplement)　2021

    ISSN： 2424-1709

  46. 脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

    石田誠, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 浮城一司, 冨永悌二, 中里信和, 中里信和

    臨床神経生理学(Web)　49　(5)　2021

    ISSN： 2188-031X

  47. A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

    石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本生体医工学会大会プログラム・抄録集(Web)　60th　2021

  48. A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

    土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

    日本生体医工学会大会プログラム・抄録集(Web)　60th　2021

  49. Efficacy of medical cooperation system in epilepsy-surgery clinic in Aomori

    大沢伸一郎, 柿坂庸介, 浮城一司, 神一敬, 村上謙介, 川村強, 中里信和, 冨永悌二

    てんかん研究　39　(2)　2021

    ISSN： 0912-0890

  50. Age-related seizure outcome after one-stage complete corpus callosotomy

    浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 植松貢, 山本哲哉, 冨永悌二, 中里信和

    てんかん研究　39　(2)　2021

    ISSN： 0912-0890

  51. A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

    土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

    日本生体磁気学会誌　34　(1)　2021

    ISSN： 0915-0374

  52. A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

    石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

    日本生体磁気学会誌　34　(1)　2021

    ISSN： 0915-0374

  53. 超選択的Wada testによるオーダーメイド的局所脳機能評価

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 新妻邦泰, 神一敬, 浅黄優, 中里信和, 冨永悌二

    臨床神経生理学(Web)　48　(5)　2020

    ISSN： 2188-031X

  54. Utility of somatosensory evoked magnetic fields for lip stimulation: An epilepsy case with right paracentral lobule focal cortical dysplasia

    菅野彰剛, 神一敬, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 石田誠, 大沢伸一郎, 冨永悌二, 中里信和, 中里信和

    日本生体磁気学会誌　33　(1)　2020

    ISSN： 0915-0374

  55. Surgical indication and treatment strategy for the patients with epileptic foci in sensory-motor cortex

    大沢伸一郎, 鈴木匡子, 浮城一司, 神一敬, 植松貢, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　44th　2020

  56. Super-selective infusion of propofol to posterior cerebral artery predict post-operative macular sparing in the case of occipital lobe epilepsy with bilateral occipital injury

    古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 金森政之, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　44th　2020

  57. オーダーメイド的脳機能評価における超選択的Wada testの有用性

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　43rd　2020

  58. 放線方向を主たる活動とした“bottom of sulcus”を呈する皮質形成異常前頭葉てんかん1症例への脳磁図を用いた解析

    菅野彰剛, 神一敬, 大沢伸一郎, 石田誠, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　43rd　2020

  59. 15歳以上の難治てんかんに対する全脳梁離断術の有効性について

    浮城一司, 大沢伸一郎, 岩崎真樹, 山本哲哉, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　43rd　2020

  60. 超選択的Wada test時に発作と同様の症状を呈した2例

    古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 神一敬, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　43rd　2020

  61. 深部電極による機能マッピングで証明された中心溝深部の運動機能局在

    下田由輝, 下田由輝, 大沢伸一郎, 浮城一司, 上利大, 柿沼一雄, 古知龍三郎, 神一敬, 鈴木匡子, 中里信和, 冨永悌二

    日本てんかん外科学会プログラム・抄録集　43rd　2020

  62. 左側中側頭回後方の皮質電気刺激により特徴的な幻聴を呈した1例

    浮城一司, 大沢伸一郎, 柿沼一雄, 細川大瑛, 佐藤貴文, 冨永悌二, 鈴木匡子, 中里信和

    日本ヒト脳機能マッピング学会プログラム・抄録集　22nd　2020

  63. Order-made evaluation of brain function by super-selective Wada test in the candidate patients of epilepsy surgery

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　22nd　2020

  64. 発作時に気分高揚を示唆する言動を呈した右内側側頭葉てんかんの一例

    土屋真理夫, 神一敬, 神一敬, 柿坂庸介, 柿坂庸介, 大沢伸一郎, 上利大, 浮城一司, 中里信和, 中里信和

    てんかん研究　37　(3)　844-844　2020

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  65. 特異な眼球運動を伴う非定型欠神発作を認めた歯状核赤核淡蒼球ルイ体萎縮症の一例

    浮城一司, 神一敬, 神一敬, 豊嶋昌弥, 柿坂庸介, 柿坂庸介, 上利大, 土屋真理夫, 中里信和, 中里信和

    てんかん研究　37　(3)　12　2020

    ISSN： 0912-0890

  66. 超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価

    大沢 伸一郎, 鈴木 匡子, 新妻 邦泰, 浮城 一司, 柿沼 一雄, 上利 大, 神 一敬, 斎藤 竜太, 金森 政之, 中里 信和, 冨永 悌二

    脳血管内治療　4　(Suppl.)　S383-S383　2019/11

    Publisher: (NPO)日本脳神経血管内治療学会

    ISSN： 2423-9119

    eISSN： 2424-1709

  67. てんかん外科に必要な術中マッピング 超選択的Wada testによるオーダーメイド的脳機能評価

    大沢 伸一郎, 鈴木 匡子, 浮城 一司, 柿沼 一雄, 上利 大, 浅黄 優, 新妻 邦泰, 三木 俊, 神 一敬, 中里 信和, 冨永 悌二

    臨床神経生理学　47　(5)　358-358　2019/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  68. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

    菅野 彰剛, 神 一敬, 大沢 伸一郎, 柿坂 庸介, 上利 大, 浮城 一司, 土屋 真理夫, 佐藤 志帆, 麦倉 俊司, 中里 信和

    臨床神経生理学　47　(5)　436-436　2019/10

    Publisher: (一社)日本臨床神経生理学会

    ISSN： 1345-7101

    eISSN： 2188-031X

  69. Tele-epilepsy conference : How we can maximize an educational effect of teleconference system

    柿坂 庸介, 神 一敬, 上利 大, 土屋 真理夫, 浮城 一司, 大沢 伸一郎, 中里 信和

    日本遠隔医療学会雑誌　15　(2)　127-129　2019/09

    Publisher: (一社)日本遠隔医療学会

    ISSN： 1880-800X

  70. 左側頭後頭葉底面の皮質電気刺激により顔の幻視とパレイドリアを呈した1例

    細川大瑛, 柿沼一雄, 上利大, 浮城一司, 佐藤貴文, 大沢伸一郎, 神一敬, 中里信和, 富永悌二, 鈴木匡子

    日本高次脳機能障害学会学術総会プログラム・講演抄録　43rd　2019

  71. MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

    菅野彰剛, 神一敬, 大沢伸一郎, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 佐藤志帆, 麦倉俊司, 中里信和, 中里信和

    臨床神経生理学(Web)　47　(5)　2019

    ISSN： 2188-031X

  72. Wada testの発展的手法により明らかになった非典型的な言語局在の症例

    柿沼一雄, 大沢伸一郎, 菅野彰剛, 浮城一司, 上利大, 柿坂庸介, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

    日本ヒト脳機能マッピング学会プログラム・抄録集　21st　70　2019

  73. 言語優位半球下前頭回深部の電気刺激による音認知の変容

    大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 古知龍三郎, 神一敬, 中里信和, 冨永悌二

    日本ヒト脳機能マッピング学会プログラム・抄録集　21st　72　2019

  74. 若年ミオクロニーてんかんの発作時脳波の多様性

    土屋真理夫, 神一敬, 浮城一司, 上利大, 北澤悠, 柿坂庸介, 中里信和

    てんかん研究　37　(2)　688-688　2019

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  75. 超選択的Wada testによるオーダーメイド的脳機能評価

    大沢伸一郎, 鈴木匡子, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 中里信和, 冨永悌二

    てんかん研究　37　(2)　693-693　2019

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  76. 高齢症例の脳梁離断術における術式選択と術後転帰の検討

    浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 山本哲哉, 冨永悌二, 中里信和

    てんかん研究　37　(2)　656-656　2019

    Publisher: (一社)日本てんかん学会

    ISSN： 0912-0890

    eISSN： 1347-5509

  77. A case of frontal lobe epilepsy in which MEG source was successfully estimated by a spatial filter method for averaged spikes

    菅野彰剛, 菅野彰剛, 神一敬, 神一敬, 大沢伸一郎, 石田誠, 柿坂庸介, 柿坂庸介, 上利大, 上利大, 浮城一司, 土屋真理夫, 中里信和, 中里信和

    日本生体磁気学会誌　32　(1)　114-115　2019

    Publisher: 日本生体磁気学会

    ISSN： 0915-0374

  78. 脳梁離断術後の急性離断症状改善経過

    浮城一司, 大沢伸一郎, 岩崎真樹, 神一敬, 山本哲哉, 冨永悌二, 中里信和

    日本てんかん外科学会プログラム・抄録集　42nd　81　2019

  79. 急速に進行したrhabdoid featureを呈する脳腫瘍の1例

    竪月順也, 大谷方子, 飯田悠, 浮城一司, 小林夏樹, 宮崎良平, 間中浩, 川崎隆, 柳下三郎, 坂田勝巳

    Brain Tumor Pathology　32　(Supplement)　081-081　2015/05

    Publisher: 日本脳腫瘍病理学会

    ISSN： 1433-7398

  80. 巨大脊髄髄内腫瘍の手術―staged surgeryの実際と効果―

    稲垣浩, 村田英俊, 田中貴大, 安部克哉, 浮城一司, 笹目丈, 吉川信一朗, 安久正哲, 東田哲博, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　125　2015

  81. 脊髄髄内腫瘍の手術:摘出と機能温存の両立を目指した剥離操作の工夫

    村田英俊, 田中貴大, 東田哲博, 吉川信一朗, 安久正哲, 稲垣浩, 笹目丈, 浮城一司, 高瀬創, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　109　2015

  82. 脊髄上衣腫の手術

    笹目丈, 村田英俊, 安久正晢, 東田晢博, 稲垣浩, 浮城一司, 田中貴大, 吉川信一郎, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　147　2015

  83. 頭蓋頚椎移行部病変に対する手術の基本と工夫

    田中貴大, 村田英俊, 稲垣浩, 笹目丈, 浮城一司, 安久正哲, 吉川信一朗, 東田哲博, 高瀬創, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　139　2015

  84. 頸椎OPLLの外科治療:前方手術と後方手術の役割

    村田英俊, 田中貴大, 稲垣浩, 東田哲博, 吉川信一朗, 安久正哲, 笹目丈, 浮城一司, 高瀬創, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　134　2015

  85. 高齢者頸椎変性疾患に対する脊椎手術の検討

    田中貴大, 村田英俊, 稲垣浩, 笹目丈, 浮城一司, 安久正哲, 吉川信一朗, 東田哲博, 高瀬創, 川原信隆

    日本脊髄外科学会プログラム・抄録集　30th　246　2015

  86. 脳動脈瘤瘤内塞栓術における術中破裂後の長期予後

    竪月順也, 間中浩, 浮城一司, 宮崎良平, 川崎隆, 坂田勝巳

    Journal of Neuroendovascular Therapy　8　(6)　206-206　2014/12/01

    Publisher: (NPO)日本脳神経血管内治療学会

    ISSN： 1882-4072

  87. 後下小脳動脈を含む破裂解離性椎骨動脈瘤の血管内手術

    間中浩, 竪月順也, 濱田幸一, 浮城一司, 宮崎良平, 笹目丈, 川崎隆, 坂田勝巳

    Journal of Neuroendovascular Therapy　8　(6)　209-209　2014/12/01

    Publisher: (NPO)日本脳神経血管内治療学会

    ISSN： 1882-4072

Show all ︎Show first 5

Research Projects 1

  1. 独自開発アプリにより収得した大規模情報を用いたてんかん発作予報アルゴリズムの開発

    浮城 一司

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2024/04 - 2026/03

Media Coverage 1

  1. 気になる症状すっきり診断 東北大学病院専門ドクターに聞く「成人で発症するてんかん」 Myself

    河北新報社　河北新報

    2024/06/28

    Type: Newspaper, magazine