Details of the Researcher

PHOTO

Michiaki Unno
Section
Graduate School of Medicine
Job title
Professor
Degree

  • 博士（医学）（東北大学）

Profile

昭和55年4月 東北大学医学部入学
昭和61年4月 水戸協同病院外科勤務（初期研修）
昭和63年4月 東北大学第一外科入局、医学部附属病院医員（研修医）
平成元年4月 東北大学大学院医学研究科入学
平成5年4月 日本学術振興会特別研究員（ＰＤ）採用
平成7年4月 仙台市医療センター仙台オープン病院外科副医長
平成8年4月 東北大学医学部・第一外科・助手
平成14年11月 東北大学病院・肝胆膵外科・講師
平成17年8月 東北大学大学院・消化器外科学分野・教授
平成24年4月 東北大学病院副院長（平成27年3月まで）

Education 2

  • Tohoku University　Graduate School, Division of Medicine　外科学

    - 1993/03

  • Tohoku University　Faculty of Medicine

    - 1986/03

Committee Memberships 35

  • 日本外科感染症学会　理事

    2021/04 - Present

  • 日本膵臓学会　理事

    2018/06 - Present

  • 日本消化器病学会　広報委員会

    2017/03 - Present

  • 日本消化器病学会　理事

    2017/03 - Present

  • 日本胆道学会　理事長

    2017/01 - Present

  • 日本外科学会　理事

    2016/04 - Present

  • 日本腹部救急医学会　理事

    2015/03 - Present

  • 日本外科病理学会　理事

    2010/12 - Present

  • 日本外科病理学会　理事

    2010/12 - Present

  • 日本がん転移学会　評議員

    2009/07 - Present

  • 日本がん転移学会　評議員

    2009/07 - Present

  • 肝臓内視鏡外科研究会　評議員

    2008/09 - Present

  • 肝臓内視鏡外科研究会　評議員

    2008/09 - Present

  • 日本肝胆膵外科学会　理事

    2008/04 - Present

  • 日本肝胆膵外科学会　理事

    2008/04 - Present

  • 日本胆道学会　評議員

    2006/09 - Present

  • 日本胆道学会　評議員

    2006/09 - Present

  • 日本外科学会　評議員

    2006/04 - Present

  • 日本癌治療学会　編集委員

    2006/04 - Present

  • 日本胆道学会　編集委員

    2006/04 - Present

  • 日本外科学会　評議員

    2006/04 - Present

  • 日本癌治療学会　編集委員

    2006/04 - Present

  • 日本胆道学会　編集委員

    2006/04 - Present

  • 宮城手術画像研究会　会長

    2006/01 - Present

  • 宮城肝胆膵癌化学療法研究会　会長

    2006/01 - Present

  • 宮城手術画像研究会　会長

    2006/01 - Present

  • 宮城肝胆膵癌化学療法研究会　会長

    2006/01 - Present

  • 日本肝胆膵外科学会　評議員

    2005/08 - Present

  • 日本肝臓学会東部会　評議員

    2005/08 - Present

  • 日本肝胆膵外科学会　評議員

    2005/08 - Present

  • 日本肝臓学会東部会　評議員

    2005/08 - Present

  • 日本消化器病学会　評議員

    2004/12 - Present

  • 日本消化器病学会　評議員

    2004/12 - Present

  • 日本外科学会　編集委員

    2007/04 - 2017/03

  • 日本外科学会　編集委員

    2007/04 - 2017/03

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Professional Memberships 46

  • 宮城インターベンション研究会(2006/04- 世話人)

  • 東北肝臓外科研究会(2006/04- 世話人)

  • 日本外科学会(1986/04-)

  • 日本外科学会(2006/04- 試験問題検討小委員会)

  • 日本胆汁酸研究会(2006/04- 世話人)

  • 東北胆膵癌研究会(2006/10- 世話人)

  • 宮城肝癌治療研究会(2005/07- 世話人)

  • 日本胆道学会(2006/04- 編集委員)

  • 日本外科学会(2007/04- 定款委員)

  • 日本外科学会(2006/04- 広報委員)

  • 日本胆道学会(2006/04- 胆道癌取扱い規約委員)

  • 東北外科集談会(2006/04- 世話人)

  • 日本外科学会(2007/04- 将来構想委員会)

  • 日本癌治療学会(2006/04- 編集委員)

  • 日本外科学会(2007/04-2017/03 編集委員)

  • 宮城手術画像研究会(2006/01- 会長)

  • 日本外科学会(2006/04- 評議員)

  • 日本胆道学会(2006/09- 評議員)

  • 日本肝臓学会東部会(2005/08- 評議員)

  • 日本肝胆膵外科学会(2005/08- 評議員)

  • 日本消化器病学会(2004/12- 評議員)

  • 外科侵襲とサイトカイン研究会(2009/04- 世話人)

  • 日本外科病理学会(2010/12- 理事)

  • 肝臓内視鏡外科研究会(2008/09- 評議員)

  • 日本がん転移学会(2009/07- 評議員)

  • 日本胆膵生理機能研究会(2007/06- 世話人)

  • 日本肝胆膵外科学会(2008/04- 高度技能指導医認定小委員会委員長)

  • 日本肝胆膵外科学会(2008/04- 理事)

  • 日本胆道学会(2008/04- 評議員選考委員)

  • 日本肝胆膵外科学会(2008/01- Executive committee)

  • 日本外科感染症学会(2008/01-)

  • 日本内視鏡外科学会(2008/01-)

  • 東北膵臓研究会(2006/04- 世話人)

  • 日本消化器病学会(2006/08- 胆石症ガイドライン作成委員)

  • 日本膵臓学会(2005/01-)

  • 宮城GIM研究会(2006/04- 世話人)

  • 東日本胆汁酸研究会(2006/01- 世話人)

  • 宮城肝胆膵癌化学療法研究会(2006/01- 会長)

  • 東北静脈栄養研究会(2006/04- 世話人)

  • 日本結石治療研究会(2006/04- 世話人)

  • GIリサーチフォーラム(2006/04- 世話人)

  • 東北消化器周術期研究会(2006/04- 世話人)

  • 日本臨床外科学会(2006/04-)

  • ISS(2006/04-)

  • IHPBA(2006/04-)

  • SSAT(2006/04-)

︎Show all ︎Show first 5

Research Interests 7

  • gallbladder carcinoma

  • Neoadjuvant chemotherapy

  • adjuvant chemotherapy

  • surgery

  • liver cancer

  • pancreatic cancer

  • Biliary tract cancer

Research Areas 2

  • Life sciences / Digestive surgery /

  • Life sciences / Pathobiochemistry / molecular biology

Awards 1

  1. 東北医学会金賞

    2004/01　東北医学会

Papers 2454

  1. Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells Peer-reviewed

    Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa

    Scientific Reports　15　(1)　2025/04/09

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-025-97166-1 　

    eISSN： 2045-2322

  2. Neoadjuvant Chemotherapy with Gemcitabine and S-1 versus Upfront Surgery for Resectable Pancreatic Cancer: Results of the Randomized Phase II/III Prep-02/JSAP05 Trial

    Unno M, Motoi F, Matsuyama Y, Satoi S, Toyama H, Matsumoto I, Aosasa S, Shirakawa H, Wada K, Fujii T, Yoshitomi H, Takahashi S, Sho M, Ueno H, Kosuge T.

    Ann Surg.　2025/04

    DOI： 10.1097/SLA.0000000000006730. 　

  3. Annual report of Japanese biliary tract cancer registry from 2021: Focus on the rate of R0 resection, postoperative complications, and site of lymph node metastasis.

    Hiroyuki Kato, Akihiko Horiguchi, Takao Ohtsuka, Atsushi Nanashima, Michiaki Unno, Toshifumi Wakai, Fumihiko Miura, Hiroyuki Isayama, Yoshiki Hirooka, Taku Aoki, Hiroyuki Yamamoto, Ichiro Yasuda, Itaru Endo

    Journal of hepato-biliary-pancreatic sciences　2025/03/16

    DOI： 10.1002/jhbp.12129 　

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    PURPOSE: This study aimed to clarify the current treatment status for biliary tract cancers based on data from the National Clinical Database (NCD) in Japan. METHODS: Total 3895 cases of biliary tract cancers registered in the NCD during 2021 were included. We identified the rates of resection, R0 resection, postoperative complications, and incidences of lymph node metastasis for gallbladder carcinoma, perihilar cholangiocarcinoma, distal bile duct carcinoma, and ampullary carcinoma. RESULTS: The number of biliary tract cancers registered in the NCD during 2021 was 3895 (1775 in extrahepatic bile duct carcinoma, 1422 in gallbladder carcinoma, and 698 in ampullary carcinoma). In gallbladder carcinoma, the resection (89.59%) and R0 resection rates (87.99%) were favorable, and the complication rate (6.05%) was lower than that of others. However, the postoperative complication rate could be higher in T3-T4 cases and when extrahepatic bile duct resection was performed concomitantly. Lymph node metastasis was frequently seen in 12.60% at the No. 13a lymph node. In perihilar cholangiocarcinoma, the R0 resection (69.82%) and complication rates (16.75%) were significantly lower and higher, respectively. In distal cholangiocarcinoma and ampullary carcinoma, metastasis was observed in approximately 2% and 10% of the dissected No. 16b1 para-aortic lymph nodes, respectively. In conclusion, although short-term surgical outcomes for biliary tract cancers in Japan might be acceptable, the significantly lower R0 resection and higher complication rates of perihilar cholangiocarcinomas indicate additional challenges for surgeons in the future and should continue to be monitored by the Japanese Society of Hepatobiliary and Pancreatic Surgery.

  4. Wnt2 Expression in Cancer-Associated Fibroblasts Precedes Lymph Node Metastasis in Orthotopic Transplantation Mouse Model of Colorectal Cancer. Peer-reviewed

    Hideaki Karasawa, Keigo Murakami, Koh Miura, Hiroyuki Sasaki, Tomoyuki Ono, Taiki Kajiwara, Akihiro Yamamura, Takashi Kamei, Shinobu Ohnuma, Toru Furukawa, Michiaki Unno

    The Tohoku journal of experimental medicine　2025/03/13

    DOI： 10.1620/tjem.2025.J039 　

  5. High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.

    Takashi Kokumai, Shuichi Aoki, Kei Nakagawa, Masahiro Iseki, Hideaki Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　2025/02/13

    DOI： 10.1002/jhbp.12111 　

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    BACKGROUND: Hemihepatectomy with extrahepatic bile duct resection is considered the only curative treatment for perihilar cholangiocarcinoma. The aim of the study was to clarify the survival benefits in this invasive surgical procedure for elderly patients. METHODS: A total of 290 patients who underwent surgical resection for perihilar cholangiocarcinoma in our department from 2000 to 2020 were categorized into the E group (62 patients aged ≥75 years) and NE group (228 patients aged <74 years). RESULTS: The E group exhibited decreased pathological lymph node metastasis (p = .001) and had a shorter operative time (p = .021) and fewer cases of combined vascular resection (p = .002). We found no significant differences in postoperative mortality; however, disease-specific survival was significantly better in the E group (3-year survival: 75.6 vs. 60.3%, p = .031). After propensity score matching, overall survival and disease-specific survival did not differ between the two groups; nevertheless, the hospital mortality rate was significantly higher in the E group (11.5 vs. 1.6%, p = .020). In the E group, a high preoperative Glasgow prognostic score was the only factor associated with hospital mortality (odds ratio, 7.35; p = .026) and indicated worse prognosis. CONCLUSIONS: A high preoperative Glasgow prognostic score was associated with hospital mortality and poor prognosis in elderly patients with perihilar cholangiocarcinoma.

  6. Effects of human amniotic membrane on the angiogenesis and healing of ischemic wounds in a rat model. International-journal

    Masato Sato, Kazuaki Tokodai, Kaoru Okada, Hiroyuki Ogasawara, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Hirofumi Sugawara, Daijirou Akamatsu, Michiaki Unno, Masafumi Goto, Takashi Kamei

    Journal of biomaterials applications　39　(7)　789-796　2025/02

    DOI： 10.1177/08853282241289919 　

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    Although the human amniotic membrane (hAM) has been demonstrated to promote angiogenesis, its efficacy in healing ischemic wounds remains unknown. Therefore, the current study aimed to evaluate the potential of hAM as a dressing for treating ischemic wounds. The inferior abdominal wall arteries and veins of male rats were divided, and an ischemic wound was created on each side of the abdominal wall. Of the two ischemic wounds created, only one was covered with hAM, and its wound healing effect was determined by measuring the wound area. Angiogenesis was assessed by measuring microvessel density (MVD). On day 5, the mean wound area changed from 400 mm2 to 335.4 (260-450) mm2 in the hAM group and to 459 (306-570) mm2 in the control group (p = 0.0051). MVD was 19.0 (10.4-24.6) in the hAM group and 15.1 (10.6-20.8) in the control group (p = 0.0026). No significant differences in local pro- and anti-inflammatory cytokine levels were observed between the two groups. Histological examination revealed no rejection of the transplanted hAM. Therefore, the hAM may serve as a novel wound dressing that can promote angiogenesis and healing in ischemic wounds.

  7. Optimal preoperative treatment strategy for conversion surgery in unresectable locally advanced pancreatic cancer: A project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    Satoshi Yasuda, Sohei Satoi, Hideki Takami, Satoshi Hirano, Hirofumi Akita, Yu Takahahshi, Ippei Matsumoto, Michiaki Unno, Riki Ninomiya, Manabu Kawai, Yuichi Nagakwa, Teiichi Sugiura, Naoto Yamamoto, Minako Nagai, Kenichiro Uemura, Masafumi Imamura, Naoki Ozu, Masafumi Nakamura, Masayuki Ohtsuka, Masayuki Sho

    Journal of Clinical Oncology　43　(4_suppl)　718-718　2025/02

    Publisher: American Society of Clinical Oncology (ASCO)

    DOI： 10.1200/jco.2025.43.4_suppl.718 　

    ISSN： 0732-183X

    eISSN： 1527-7755

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    718 Background: Conversion surgery (CS) for unresectable locally advanced pancreatic cancer (UR-LAPC) has been widely accepted when feasible. However, optimal preoperative treatment strategies remain unclear. To determine the most effective preoperative approach for UR-LAPC in the current treatment landscape, we conducted a project study in the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Methods: We analyzed 465 UR-LAPC patients who underwent CS following chemotherapy with FOLFIRINOX (FFX), gemcitabine plus nab-paclitaxel (GnP), or modified regimens between 2015 and 2020 across 84 Japanese board-certified training institutions. Overall survival (OS) was the primary endpoint. We used the Kaplan-Meier method for estimating survival analyses, the Cox proportional hazards model for multivariate analyses, and Maximally Selected Rank Statistics to determine the optimal preoperative treatment duration. Results: Median OS was 43.8 months, with a 5-year survival rate of 37.2%. The optimal preoperative treatment duration was 6.1 months. Patients receiving &gt;6 months of preoperative treatment (n=350) showed significantly better median OS and recurrence-free survival (RFS) compared to ≤6 months (n=115) (50.4 vs 29.7 months and 15.6 vs 9.1 months, respectively; both P&lt;0.001 ). FFX-based regimens (n=116) showed better OS and RFS than GnP-based regimens (n=349) (65.0 vs 36.5 months and 19.3 vs 12.4 months, respectively; both P&lt;0.01 ). Multivariate analysis identified preoperative treatment &gt;6 months (HR 0.53, 95% CI 0.407-0.697, P&lt;0.001 ) and initial FFX-based regimens (HR 0.63, 95% CI 0.464-0.843, P=0.002 ) as independent prognostic factors. Additional favorable factors included normal CA19-9 and CEA levels, PNI&gt;45 before CS, adjuvant chemotherapy, R0 resection, and Evans grade III/IV. Conclusions: This large-scale retrospective study has demonstrated that preoperative treatment duration &gt;6 months and the use of FFX-based regimens as initial treatment were associated with improved survival outcomes in UR-LAPC patients undergoing CS. These findings provide critical information for considering CS in UR-LAPC patients, especially in current clinical practice.

  8. Multimodal deep-learning model using pre-treatment endoscopic images and clinical information to predict efficacy of neoadjuvant chemotherapy in esophageal squamous cell carcinoma.

    Takuma Miura, Takumi Yashima, Eichi Takaya, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Yohei Ozawa, Hirotaka Ishida, Michiaki Unno, Takuya Ueda, Takashi Kamei

    Esophagus : official journal of the Japan Esophageal Society　2025/01/10

    DOI： 10.1007/s10388-025-01106-x 　

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    BACKGROUND: Neoadjuvant chemotherapy is standard for advanced esophageal squamous cell carcinoma, though often ineffective. Therefore, predicting the response to chemotherapy before treatment is desirable. However, there is currently no established method for predicting response to neoadjuvant chemotherapy. This study aims to build a deep-learning model to predict the response of esophageal squamous cell carcinoma to preoperative chemotherapy by utilizing multimodal data integrating esophageal endoscopic images and clinical information. METHODS: 170 patients with locally advanced esophageal squamous cell carcinoma were retrospectively studied, and endoscopic images and clinical information before neoadjuvant chemotherapy were collected. Endoscopic images alone and endoscopic images plus clinical information were each analyzed with a deep-learning model based on ResNet50. The clinical information alone was analyzed using logistic regression machine learning models, and the area under a receiver operating characteristic curve was calculated to compare the accuracy of each model. Gradient-weighted Class Activation Mapping was used on the endoscopic images to analyze the trend of the regions of interest in this model. RESULTS: The area under the curve by clinical information alone, endoscopy alone, and both combined were 0.64, 0.55, and 0.77, respectively. The endoscopic image plus clinical information group was statistically more significant than the other models. This model focused more on the tumor when trained with clinical information. CONCLUSIONS: The deep-learning model developed suggests that gastrointestinal endoscopic imaging, in combination with other clinical information, has the potential to predict the efficacy of neoadjuvant chemotherapy in locally advanced esophageal squamous cell carcinoma before treatment.

  9. Anterior Mediastinal Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma: A Case Report and Literature Review. International-journal

    Tomoaki Tabata, Ryusuke Saito, Takeki Taniguchi, Kyohei Kasuda, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Takanori Morikawa, Michiaki Unno, Takashi Kamei

    Surgical case reports　11　(1)　2025

    DOI： 10.70352/scrj.cr.24-0025 　

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    INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignant tumor with a poor prognosis. Lymph node (LN) metastasis is found in 15% of ICC at the time of initial diagnosis. However, the LN metastasis to the anterior mediastinum is extremely rare. Herein, we report a case of anterior mediastinal LN metastasis of ICC. CASE PRESENTATION: The patient is a 74-year-old man who had surgery for cervical esophageal cancer. During follow-up, a low-density hepatic tumor and swollen LNs in the anterior mediastinum were detected. The tumor of the liver was diagnosed as ICC by needle biopsy. Excisional biopsy of the LN was performed and the diagnosis was metastasis of ICC. Because the prognosis of the patient with ICC Stage IVB is poor, the patient received 8 courses of chemotherapy. Although the new lesion appeared next to the main tumor, these tumors were located in the left liver. In addition, it was difficult for the patient to continue the chemotherapy due to the renal dysfunction. Hepatectomy with lymphadenectomy was performed. The patient survives without recurrence for 9 months after surgery. This is the first report of anterior mediastinal metastasis of ICC without any other organ involvement. CONCLUSIONS: Metastasis to the anterior mediastinum of hepatic tumor can be explained by the system that lymphatic fluid running under the capsule of the liver drains to the anterior mediastinal LNs through the coronary ligament. Metastasis of ICC to mediastinal LNs can occur when the tumor is located at the surface of the liver. Excisional biopsy is effective in determining the accurate disease stage and the treatment strategy.

  10. Prevention and Management of Recurrent Laryngeal Nerve Palsy in Minimally Invasive Esophagectomy: Current Status and Future Perspectives. International-journal

    Yusuke Taniyama, Hiroshi Okamoto, Chiaki Sato, Yohei Ozawa, Hirotaka Ishida, Michiaki Unno, Takashi Kamei

    Journal of clinical medicine　13　(24)　2024/12/13

    DOI： 10.3390/jcm13247611 　

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    Recurrent laryngeal nerve palsy remains a significant complication following minimally invasive esophagectomy for esophageal cancer. Despite advancements in surgical techniques and lymphadenectomy precision, the incidence of recurrent laryngeal nerve palsy has not been improved. Recurrent laryngeal nerve palsy predominantly affects the left side and may lead to unilateral or bilateral vocal cord paralysis, resulting in hoarseness, dysphagia, and an increased risk of aspiration pneumonia. While most cases of recurrent laryngeal nerve palsy are temporary and resolve within 6 to 12 months, some patients may experience permanent nerve dysfunction, severely impacting their quality of life. Prevention strategies, such as nerve integrity monitoring, robotic-assisted minimally invasive esophagectomy, and advanced dissection techniques, aim to minimize nerve injury, though their effectiveness varies. The management of recurrent laryngeal nerve palsy includes voice and swallowing rehabilitation, reinnervation techniques, and, in severe cases, surgical interventions such as thyroplasty and intracordal injection. As recurrent laryngeal nerve palsy can lead to significant postoperative respiratory complications, a multidisciplinary approach involving surgical precision, early detection, and comprehensive rehabilitation is crucial to improving patient outcomes and minimizing long-term morbidity in minimally invasive esophagectomy. This review article aims to inform esophageal surgeons and other clinicians about strategies for the prevention and management of recurrent laryngeal nerve palsy in esophagectomy.

  11. 膵頭十二指腸切除術後の経管栄養の意義についての検討

    石田 晶玄, 伊関 雅裕, 林 秀一郎, 野口 彩, 佐藤 英昭, 吉町 信吾, 日下 彬子, 志村 充広, 青木 修一, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 中川 圭, 亀井 尚, 海野 倫明

    外科と代謝・栄養　58　(6)　210-215　2024/12

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  12. The TEG 6s Global Hemostasis System is Useful for Coagulation Management in Simultaneous Pancreas and Kidney Transplantation: The First Two Cases. International-journal

    Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Hiroyuki Ogasawara, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　56　(9)　2021-2026　2024/11

    DOI： 10.1016/j.transproceed.2024.10.017 　

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    INTRODUCTION: Hypercoagulability-related graft thrombosis is the leading cause of graft failure after simultaneous pancreas-kidney transplantation (SPK). Addressing this issue is crucial to improve the outcomes of SPK recipients. Thromboelastography (TEG) has been used to assess the coagulation profiles of SPK recipients. Recently, a new-generation TEG device, the TEG 6s Global Hemostasis System, was introduced. This device offers advantages over TEG 5000, including less frequent calibration requirements, ease of use, and reduced sensitivity to movement. We hypothesized that TEG 6s would enhance coagulation management in SPK. METHODS: We report two cases of Asian female SPK recipients in whom TEG 6s was used to assess coagulation status at six preset times during and after surgery. RESULTS: Preoperatively, both patients exhibited hypercoagulability on TEG 6s. Postoperative intravenous heparin was administered, and the dose was titrated based on the TEG 6s results. Vascular thrombosis was not observed in either patient. Detailed TEG 6s and standard laboratory test results are reported. This pilot study demonstrates that TEG 6s monitoring can effectively assess coagulation status in SPK recipients, aiding in optimal coagulation management and reducing the risk of thrombotic complications leading to graft loss. The TEG 6s facilitated real-time and accurate coagulation assessment, allowing for tailored anticoagulant therapy. CONCLUSIONS: This is the first observational study to use TEG 6s in SPK recipients, indicating its potential benefits in improving patient outcomes. Further studies with larger sample sizes are warranted to validate these findings and establish comprehensive guidelines for using TEG 6s in SPK procedures.

  13. Japanese classification of pancreatic carcinoma by the Japan Pancreas Society: Eighth edition.

    Masaharu Ishida, Tsutomu Fujii, Masashi Kishiwada, Kazuto Shibuya, Sohei Satoi, Makoto Ueno, Kohei Nakata, Shigetsugu Takano, Katsunori Uchida, Nobuyuki Ohike, Yohei Masugi, Toru Furukawa, Kenichi Hirabayashi, Noriyoshi Fukushima, Shuang-Qin Yi, Hiroyuki Isayama, Takao Itoi, Takao Ohtsuka, Takuji Okusaka, Dai Inoue, Hirohisa Kitagawa, Kyoichi Takaori, Masaji Tani, Yuichi Nagakawa, Hideyuki Yoshitomi, Michiaki Unno, Yoshifumi Takeyama

    Journal of hepato-biliary-pancreatic sciences　31　(11)　755-768　2024/11

    DOI： 10.1002/jhbp.12056 　

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    In 2023, the Japan Pancreas Society (JPS) published the new eighth edition of the Japanese classification of pancreatic carcinoma. We present here an excerpted version in English, based on the latest edition. The major changes in this revision are as follows: In the eighth edition of the Union for International Cancer Control (UICC), the T category was changed to be based on tumor size; however, the eighth edition of the Japanese classification retains the previous T category based on local invasion factors. Lymph nodes have been renamed, and regional lymph nodes have been defined by location. Peritoneal cytology, which was not previously included in distant metastasis (M), has now been included in the M category. Moreover, significant additions have been made regarding the pathological diagnosis of endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) and criteria for histological assessment of the effects after chemotherapy and radiation therapy. Although this classification is aimed at carcinoma originating in the pancreas, not in the bile duct or duodenum, if the differentiation of the primary organ is difficult, this classification should be applied. It is also desirable to describe tumors other than carcinoma and metastatic tumors to the pancreas in accordance with this classification.

  14. Calreticulin exposure induced by anticancer drugs is associated with the p53 signaling pathway in colorectal cancer cells

    Satoru Naito, Taiki Kajiwara, Hideaki Karasawa, Tomoyuki Ono, Tatsushi Saito, Ryo Funayama, Keiko Nakayama, Shinobu Ohnuma, Michiaki Unno

    Biochemical and Biophysical Research Communications　733　150665-150665　2024/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbrc.2024.150665 　

    ISSN： 0006-291X

  15. Usefulness of multigene liquid biopsy of bile for identifying driver genes of biliary duct cancers. International-journal

    Shin Ito, Mika Ando, Shuichi Aoki, Satoshi Soma, Jie Zhang, Naohiro Hirano, Ryosuke Kashiwagi, Keigo Murakami, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Koetsu Inoue, Masamichi Mizuma, Kiyoshi Kume, Kei Nakagawa, Atsushi Masamune, Naoki Asano, Jun Yasuda, Michiaki Unno

    Cancer science　2024/10/08

    DOI： 10.1111/cas.16365 　

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    Liquid biopsy (LB) is an essential tool for obtaining tumor-derived materials with minimum invasion. Bile has been shown to contain much higher free nucleic acid levels than blood plasma and can be collected through endoscopic procedures. Therefore, bile possesses high potential as a source of tumor derived cell-free DNA (cfDNA) for bile duct cancers. In this study, we show that a multigene panel for plasma LB can also be applied to bile cfDNA for comparing driver gene mutation detection in other sources (plasma and tumor tissues of the corresponding patients). We collected cfDNA samples from the bile of 24 biliary tract cancer cases. These included 17 cholangiocarcinomas, three ampullary carcinoma, two pancreatic cancers, one intraductal papillary mucinous carcinoma, and one insulinoma. Seventeen plasma samples were obtained from the corresponding patients before surgical resection and subjected to the LiquidPlex multigene panel LB system. We applied a machine learning approach to classify possible tumor-derived variants among the prefiltered variant calls by a LiquidPlex analytical package with high fidelity. Among the 17 cholangiocarcinomas, we could detect cancer driver mutations in the bile of 10 cases using the LiquidPlex system. Of the biliary tract cancer cases examined with this method, 13 (54%) and 4 (17%) resulted in positive cancer driver mutation detection in the bile and plasma cfDNAs, respectively. These results suggest that bile is a more reliable source for LB than plasma for multigene panel analyses of biliary tract cancers.

  16. GFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer

    Kent Miyazaki, Kyohei Ariake, Satoko Sato, Takayuki Miura, Jingyu Xun, Daisuke Douchi, Masaharu Ishida, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    Clinical & Experimental Metastasis　2024/10

    DOI： 10.1007/s10585-024-10298-y 　

  17. 胆道癌に対する集学的治療 切除不能胆道癌に対するconversion surgeryの現状と課題

    青木 修一, 中川 圭, 伊関 雅裕, 佐藤 英昭, 吉町 信吾, 日下 彬子, 志村 充広, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 大沼 忍, 海野 倫明

    日本癌治療学会学術集会抄録集　62回　OWS6-5　2024/10

    Publisher: (一社)日本癌治療学会

  18. [Ⅱ. Precision Medicine in Cholangiocarcinoma].

    Kei Nakagawa, Hideaki Sato, Masahiro Iseki, Shuichi Aoki, Akiko Kusaka, Daisuke Douchi, Takayuki Miura, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　51　(10)　989-992　2024/10

    ISSN： 0385-0684

  19. 膵島移植においてアロ免疫拒絶制御以外に別の膵島生着促進作用も併せ持つ新規免疫抑制薬の開発

    鈴木 翔輝, 猪村 武弘, 稲垣 明子, 前川 正充, 奥平 貴成, 片野 匠, 公文代 將希, 佐藤 裕, 戸子台 和哲, 海野 倫明, 亀井 尚, 渡邉 君子, 後藤 昌史

    Organ Biology　31　(3)　106-106　2024/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  20. Liver,Pancreas,Biliary Tract Cancer 肝・胆・膵癌 肝胆膵癌におけるPrecision Medicineの展開 胆管癌におけるPrecision Medicine

    中川 圭, 佐藤 英昭, 伊関 雅裕, 青木 修一, 日下 彬子, 堂地 大輔, 三浦 孝之, 石田 晶玄, 水間 正道, 海野 倫明

    癌と化学療法　51　(10)　989-992　2024/10

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  21. Optimal treatment strategy for patients with pancreatic cancer having positive peritoneal cytology: A nationwide multicenter retrospective cohort study supervised by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    Kyohei Ariake, Masamichi Mizuma, Michiaki Unno, Sohei Satoi, Naoto Yamamoto, Masamichi Hayashi, Manabu Kawai, Hirofumi Akita, Eiji Toyoda, Tsutomu Fujii, Masaru Sasaki, Kenichi Hakamada, Jota Watanabe, Etsuro Hatano, Masaaki Hidaka, Satoshi Hirano, Hiroshi Kurahara, Ippei Matsumoto, Goro Honda, Toshiro Ogura, Masafumi Nakamura, Itaru Endo

    Journal of hepato-biliary-pancreatic sciences　2024/09/24

    DOI： 10.1002/jhbp.12074 　

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    BACKGROUND: The aim of this study was to determine the optimal treatment for patients with pancreatic cancer (PaCa) having positive peritoneal cytology (PPC). METHODS: This multicenter retrospective study included patients with PPC treated at 78 high-volume centers between January 2012 and December 2020. Prognoses after resection (S-group) and initiation of nonsurgical treatment (N-group) were compared. Prognostic factors for survival in both groups were analyzed. Detailed characteristics of conversion surgery (CS) in the N-group were evaluated. RESULTS: In total, 568 enrolled patients were classified into an S-group (n = 445) or an N-group (n = 123). Median survival times (MSTs) were 19.0 months and 19.3 months, respectively, with no significant difference in prognosis (p = .845). The intervenable prognostic factors for survival were adjuvant treatment in the S-group (p < .001) and CS in the N-group (p < .001). Following CS, the MST was prolonged to 45.6 months, and peritoneal or liver recurrence decreased considerably. CS can be expected if PPC is diagnosed before neoadjuvant treatment and when combination treatment is initiated. CONCLUSION: Surgical resection may not be beneficial for improving survival when PPC is evident. Chemotherapy aiming for CS may be the optimal treatment for such patients.

  22. Practical Coagulation Management in Liver Transplantation through Point-of-Care Analysis using the TEG 6s Global Hemostasis System in Japan.

    Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Koji Miyazawa, Atsushi Fujio, Hiroyuki Ogasawara, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　2024/09/05

    DOI： 10.1620/tjem.2024.J087 　

  23. 進行胆道癌に対する集学的治療の現状と展望 胆道癌に対するConversion Surgery

    佐藤 英昭, 中川 圭, 海野 倫明

    胆道　38　(3)　301-301　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  24. 当科におけるIntracystic papillary neoplasm切除例の検討

    三浦 孝之, 中川 圭, 伊関 雅裕, 青木 修一, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 堂地 大輔, 前田 晋平, 石田 晶玄, 水間 正道, 古川 徹, 海野 倫明

    胆道　38　(3)　453-453　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  25. 胆道癌における胆汁cfDNAのリキッドバイプシーとしての有用性

    青木 修一, 中川 圭, 海野 倫明, 伊関 雅裕, 佐藤 英昭, 吉町 信吾, 日下 彬子, 志村 充広, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道

    胆道　38　(3)　488-488　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  26. 胆道癌ドライバー遺伝子探索における胆汁リキッドバイオプシー遺伝子パネル検査の有用性(Multi-gene Liquid Biopsy for bile juice may be useful to search driver genes of biliary duct cancers)

    伊藤 信, 安藤 未佳, 青木 修一, Zhang Jie, 平野 直大, 柏木 良介, 村上 圭吾, 吉町 信吾, 佐藤 英昭, 日下 彬子, 伊関 雅裕, 井上 亨悦, 水間 正道, 中川 圭, 安田 純, 海野 倫明, 安田 純

    日本癌学会総会記事　83回　P-3275　2024/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  27. 進行胆道癌に対する集学的治療の現状と展望 胆道癌に対するConversion Surgery

    佐藤 英昭, 中川 圭, 海野 倫明

    胆道　38　(3)　301-301　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  28. 高齢者肝門部領域胆管癌に対する肝葉切除における安全性及び予後の検討 術前Glasgow Prognostic Score高値が周術期死亡のリスク因子となる

    國米 崇, 青木 修一, 中川 圭, 伊関 雅裕, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 亀井 尚, 海野 倫明

    胆道　38　(3)　426-426　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  29. 当科におけるIntracystic papillary neoplasm切除例の検討

    三浦 孝之, 中川 圭, 伊関 雅裕, 青木 修一, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 堂地 大輔, 前田 晋平, 石田 晶玄, 水間 正道, 古川 徹, 海野 倫明

    胆道　38　(3)　453-453　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  30. 胆道癌における胆汁cfDNAのリキッドバイプシーとしての有用性

    青木 修一, 中川 圭, 海野 倫明, 伊関 雅裕, 佐藤 英昭, 吉町 信吾, 日下 彬子, 志村 充広, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道

    胆道　38　(3)　488-488　2024/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  31. Preoperative chemotherapy with Gemcitabine for pancreatic cancer causes zinc deficiency. International-journal

    Masahiro Iseki, Masamichi Mizuma, Mitsuhiro Shimura, Takashi Kokumai, Hideaki Sato, Akiko Kusaka, Shuichi Aoki, Koetsu Inoue, Shun Nakayama, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    Pancreas　2024/08/06

    DOI： 10.1097/MPA.0000000000002396 　

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    OBJECTIVES: The aim of this study was to investigate how preoperative chemotherapy affected the serum zinc concentrations in patients with pancreatic cancer (PC). METHODS: Two hundreds and thirty-one patients with PC who underwent pancreatectomy at our department from 2013 to 2019 were enrolled in this study and measured for the serum zinc concentrations before pancreatectomy. Patient characteristics, course of treatment, and laboratory data were analyzed. RESULTS: One hundred thirty-five patients underwent upfront pancreatectomy and 58 received preoperative Gemcitabine + S1 (GEM + S1) and 29 received Gemcitabine + nab-Paclitaxel (GEM + nab-PTX). Comparing the serum zinc concentrations before and after preoperative treatment, it was found to decrease after treatment with statistical difference (79.3 μg/dl vs. 68.7 μg/dl, p < 0.001). The result was consistent with the investigation for both the patients who received GEM + S1 and those who received GEM + nab-PTX (p = 0.019, p < 0.001, respectively). CONCLUSIONS: The preoperative chemotherapy consistently reduced the serum zinc concentrations in the PC patients, regardless of their regimen such as GEM + S1 and GEM + nab-PTX. Monitoring the serum zinc concentration and appropriate zinc supplementation may be essential for PC patients undergoing preoperative chemotherapy and pancreatectomy.

  32. Deep learning predicts the 1-year prognosis of pancreatic cancer patients using positive peritoneal washing cytology

    Aya Noguchi, Yasushi Numata, Takanori Sugawara, Hiroshu Miura, Kaori Konno, Yuzu Adachi, Ruri Yamaguchi, Masaharu Ishida, Takashi Kokumai, Daisuke Douchi, Takayuki Miura, Kyohei Ariake, Shun Nakayama, Shimpei Maeda, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Hiromu Morikawa, Jun Akatsuka, Ichiro Maeda, Michiaki Unno, Yoichiro Yamamoto, Toru Furukawa

    Scientific Reports　14　(1)　2024/08/02

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-67757-5 　

    eISSN： 2045-2322

  33. 膵・胆管合流異常を伴う胆嚢癌の半数がHER2陽性である

    朱 銘, 堂地 大輔, 右田 修介, 力山 真樹, 林 秀一郎, 野口 彩, 伊藤 泰斗, 國米 崇, 吉町 信吾, 佐藤 英昭, 志村 充広, 日下 彬子, 青木 修一, 伊関 雅裕, 村上 圭吾, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 古川 徹, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　47　17-17　2024/08

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  34. Serum C-reactive protein and procalcitonin levels in patients with pneumonia and anastomotic leakage in the postoperative period after esophagectomy.

    Hirotaka Ishida, Toshiaki Fukutomi, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Yohei Ozawa, Ryohei Ando, Yasuharu Shinozaki, Michiaki Unno, Takashi Kamei

    General thoracic and cardiovascular surgery　2024/07/29

    DOI： 10.1007/s11748-024-02065-3 　

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    OBJECTIVE: Despite being a less-invasive procedure, esophagectomy can cause severe infectious complications, such as pneumonia and anastomotic leakage. Herein, we aimed to clarify the inflammatory characteristics of pneumonia/anastomotic leakage after esophagectomy by assessing the difference between the postoperative trends of serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with pneumonia/anastomotic leakage using the values on the consecutive postoperative day (POD). METHODS: This study included 439 patients who underwent minimally invasive esophagectomy. Serum CRP and PCT levels were measured on PODs 1-7, 10, and 14. Pneumonia and anastomotic leakage were defined as Clavien-Dindo grades ≥ 2. RESULTS: Pneumonia and anastomotic leakage occurred in 96 and 51 patients, respectively. The CRP and PCT levels peaked on POD 3 (11.6 ± 6.8 mg/dL) and POD 2 (0.69 ± 2.9 ng/mL), respectively. Between PODs 3 and 14, CRP levels were significantly higher in patients with pneumonia and anastomotic leakage than in those without complications (P < 0.001). Between PODs 3 and 14, PCT levels were significantly higher in patients with pneumonia; however, on most PODs, there were no significant differences in PCT levels between patients with and without anastomotic leakage. CONCLUSION: Inflammatory reactions caused by pneumonia may be more intense than those caused by anastomotic leakage after esophagectomy. Postoperative trends in serum CRP and PCT levels may vary depending on the complication type. Pneumonia and anastomotic leakage after esophagectomy can be potentially distinguished by the postoperative trend of PCT values before detailed examinations, such as computed tomography and endoscopy.

  35. The usefulness of gel immersion endoscopy in identifying herald bleeding from an infectious aortoenteric fistula: a case report.

    Suguo Suzuki, Masahiro Saito, Kaname Uno, Naoki Asano, Tomoyuki Koike, Daijirou Akamatsu, Masamichi Mizuma, Takashi Kamei, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　2024/07/23

    DOI： 10.1007/s12328-024-02020-y 　

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    A 62-year-old male with a history of stent graft replacement for an infectious aortic aneurysm, followed by multiple interventions for postoperative complications, was admitted with melena and anemia. Enhanced computed tomography (eCT) demonstrated fluffing and hyperdensities surrounding the graft, despite no evidence of an aortoenteric fistula (AEF). Emergency esophagogastroduodenoscopy (EGD) showed a massive bleeding in the reconstructed tract and the protruding lesion of postoperative granulation tissue with clots at the end of the blind pouch. Thereafter, hemorrhage temporarily reoccurred several times; however, the source could not be identified using eCT or EGD. Finally, on the third attempt, we performed gel immersion endoscopy (GIE) with manual injection of VISCOCLEARⓇ, and it showed purulent blood flowing from one side of the protruding lesion in the pouch. Based on the eCT findings showing exudation of the contrast agent from the graft into the pouch, we made a diagnosis of an AEF. However, radical surgery was not performed because of the patient's poor general condition. During conservative management, he died of uncontrolled bleeding from the AEF on the 5th day of hospitalization. This is the first case in which the GIE might provide tips to identify herald bleeding from a lethal AEF.

  36. Three Molecular Developmental Pathways of Remnant Pancreatic Cancer after Resection: A Nationwide Project Study of Japan Pancreas Society. International-journal

    Shuji Suzuki, Yuko Omori, Yusuke Ono, Katsuya Hirose, Taito Itoh, Hidenori Karasaki, Mitsugi Shimoda, Yuichi Nagakawa, Ryota Higuchi, Itaru Endo, Toshiki Rikiyama, Michiaki Unno, Tsutomu Fujii, Yuki Sunagawa, Hidetoshi Eguchi, Hideki Sasanuma, Takahiro Akahori, Keiichi Okano, Masaji Tani, Satoshi Hirano, Yasuhiro Shimizu, Minoru Kitago, Shugo Mizuno, Tomohisa Yamamoto, Masayuki Furukawa, Masayuki Ohtsuka, Motokazu Sugimoto, Akira Matsushita, Kenichi Hakamada, Hisato Igarashi, Tamotsu Kuroki, Satoshi Tanno, Yoshihisa Tsuji, Atsushi Masamune, Kazuhiro Mizumoto, Yoshiki Hirooka, Hiroki Yamaue, Kazuichi Okazaki, Sohei Satoi, Yoshifumi Takeyama, Yusuke Mizukami, Toru Furukawa

    Annals of surgery　2024/07/17

    DOI： 10.1097/SLA.0000000000006444 　

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    OBJECTIVE: This study aimed to clarify the molecular mechanism of remnant pancreatic cancer (PC) development after primary PC resection. SUMMARY BACKGROUND DATA: Molecular mechanisms of the development of remnant PCs following primary PC resection are largely unknown. METHODS: Forty-three patients undergoing remnant PC resection after primary PC resection between 2001 and 2017 at 26 institutes were retrospectively analyzed. Clinicopathological features and molecular alterations detected by targeted amplicon sequencing of 36 PC-associated genes were evaluated. RESULTS: These patients showed significantly lower body mass indices and higher hemoglobin A1c values at remnant PC resection than at primary PC resection. A comparison of the molecular features between primary and remnant PCs indicated that remnant PCs were likely to develop via three different molecular pathways: successional, showing identical and accumulated alterations (n=14); phylogenic, showing identical and distinct alterations (n=26); and distinct, showing independent distinctive alterations (n=3). The similarity of gene alterations was associated with time to the remnant PC development (r=－0.384, P=0.0173). Phylogenic pathways were significantly associated with the intraductal spread of carcinoma (P=0.007). Patient survival did not differ significantly depending on these molecular pathways. CONCLUSION: Molecular profiling uncovered three pathways for the development of remnant PCs, namely, successional, phylogenic, and distinct pathways. The vast majority of remnant PCs are likely to be molecularly associated with primary PCs either in the successional or phylogenic way. This information could impact the design of a strategy for monitoring and treating remnant PCs.

  37. 審査腹腔鏡に関する改訂ポイントと今後の課題

    石田 晶玄, 水間 正道, 佐藤 英昭, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 中川 圭, 海野 倫明

    膵臓　39　(3)　A133-A133　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  38. 肝転移を伴った膵神経内分泌腫瘍の治療戦略 膵神経内分泌腫瘍肝転移に対する肝切除を含む集学的治療例の検討

    三浦 孝之, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    膵臓　39　(3)　A226-A226　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  39. 急性膵炎の外科手術の変遷

    前田 晋平, 石田 晶玄, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 水間 正道, 中川 圭, 海野 倫明

    膵臓　39　(3)　A491-A491　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  40. 【肝胆膵癌に対する集学的治療の新潮流】膵癌 切除可能膵癌への集学的治療 術前治療

    中川 圭, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 三浦 孝之, 石田 晶玄, 水間 正道, 海野 倫明

    肝胆膵　89　(1)　15-20　2024/07

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  41. 進展範囲の予測が困難であった限局性膵萎縮を呈するHigh-grade PanINの1切除例

    右田 修介, 三浦 孝之, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 三浦 晋, 石田 晶玄, 水間 正道, 村上 圭吾, 粂 潔, 中川 圭, 古川 徹, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　217回　47-47　2024/07

    Publisher: 日本消化器病学会-東北支部

  42. ロボット支援下膵尾側切除術において自動縫合器による膵切離が困難であった1例

    築地 巧人, 石田 晶玄, 野口 彩, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 水間 正道, 中川 圭, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　217回　80-80　2024/07

    Publisher: 日本消化器病学会-東北支部

  43. 膵臓移植・膵島移植・人工膵臓の現状と展望 皮下膵島移植における低酸素環境改善が移植膵島グラフトに与える影響

    三頭 啓明, 猪村 武弘, 稲垣 明子, 鈴木 翔輝, 遠藤 有希子, 片野 匠, 戸子台 和哲, 渡邉 君子, 亀井 尚, 海野 倫明, 後藤 昌史

    膵臓　39　(3)　A279-A279　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  44. 当科における食道胃接合部癌の現状と治療成績の検討

    石田 裕嵩, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　79回　901-902　2024/07

    Publisher: (一社)日本消化器外科学会

  45. 低侵襲食道切除術後の骨格筋量維持と栄養状態改善にむけての取り組みと課題

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　79回　1202-1202　2024/07

    Publisher: (一社)日本消化器外科学会

  46. 当院での術前治療+食道切除後の術後補助ニボルマブ療法の現状

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 篠崎 康晴, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　79回　1888-1889　2024/07

    Publisher: (一社)日本消化器外科学会

  47. 食道癌サルベージ・コンバージョン手術の術式選択とアウトカム 当科におけるsalvage食道切除術の治療戦略とその成績

    谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 篠崎 康晴, 安藤 涼平, 高橋 洵, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　78回　49-49　2024/07

    Publisher: (NPO)日本食道学会

  48. 腹腔鏡下噴門形成術後の狭窄に対し有効であった外科的治療の一例

    皆瀬 翼, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 篠崎 康晴, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　78回　247-247　2024/07

    Publisher: (NPO)日本食道学会

  49. 外科的治療により救命し得たSBチューブによる食道破裂の一例

    小林 千紗, 谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 篠崎 康晴, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　78回　344-344　2024/07

    Publisher: (NPO)日本食道学会

  50. 周術期の栄養管理の核心に迫る!～静脈栄養の未来は? 食道癌患者における年齢・栄養状態・サルコペニアによる術後栄養状態の変化と栄養管理の注意点

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 篠崎 康晴, 八嶋 嘉之, 三浦 琢磨, 大沼 忍, 海野 倫明, 亀井 尚

    外科と代謝・栄養　58　(3)　58-58　2024/07

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  51. 低侵襲食道切除後における血中CRP濃度の炎症/予後予測マーカーとしての意義

    石田 裕嵩, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 篠崎 康晴, 海野 倫明, 亀井 尚

    外科と代謝・栄養　58　(3)　86-86　2024/07

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  52. 食道裂孔ヘルニア手術により咽喉頭逆流症の改善が得られた一例

    安藤 涼平, 佐藤 千晃, 高橋 洵, 篠崎 康晴, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　217回　87-87　2024/07

    Publisher: 日本消化器病学会-東北支部

  53. 慢性膵炎・膵石症に対する内科的・外科的治療 慢性膵炎に対するFrey手術の成績

    佐藤 英昭, 石田 晶玄, 吉町 信吾, 志村 充広, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 中川 圭, 粂 潔, 正宗 淳, 海野 倫明

    膵臓　39　(3)　A243-A243　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  54. 進展範囲の予測が困難であった限局性膵萎縮を呈するHigh-grade PanINの1切除例

    右田 修介, 三浦 孝之, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 三浦 晋, 石田 晶玄, 水間 正道, 村上 圭吾, 粂 潔, 中川 圭, 古川 徹, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　217回　47-47　2024/07

    Publisher: 日本消化器病学会-東北支部

  55. 人工肛門造設を伴う腸管切除術により良好な経過を得られた腸管型ベーチェット病の一例

    安田 有希, 伊勢 一郎, 齋藤 達, 小野 智之, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 大山 秀晃, 志賀 永嗣, 角田 洋一, 正宗 淳, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　217回　93-93　2024/07

    Publisher: 日本消化器病学会-東北支部

  56. 膵癌の長期予後向上を目指して 1-膵癌早期発見の戦略と精緻診断 高異型度PanIN/膵上皮内癌・小径膵癌の分子進化モデル

    伊藤 泰斗, 大森 優子, 小野 裕介, 高橋 賢治, 國米 崇, 正宗 淳, 海野 倫明, 水上 裕輔, 古川 徹

    膵臓　39　(3)　A172-A172　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  57. 膵癌・膵IPMN手術における膵断端評価と長期予後 腫瘤を認めない早期膵癌の進展範囲

    三浦 晋, 粂 潔, 菊田 和宏, 濱田 晋, 滝川 哲也, 松本 諒太郎, 佐野 孝紀, 佐々木 滉, 林 秀大, 坂野 美紗子, 間中 友王, 石田 晶玄, 水間 正道, 海野 倫明, 正宗 淳

    膵臓　39　(3)　A222-A222　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  58. 重症急性膵炎と被包化壊死のベストプラクティス 発症後3週目の高度炎症持続例は予後不良であり,治療介入すべきか

    粂 潔, 佐野 貴紀, 池田 未緒, 松本 諒太郎, 滝川 哲也, 三浦 晋, 間中 友王, 坂野 美紗子, 林 秀大, 佐々木 滉, 濱田 晋, 菊田 和宏, 中川 圭, 海野 倫明, 正宗 淳

    膵臓　39　(3)　A248-A248　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  59. HRSを伴う高齢者IPMNの非手術症例の予後について

    粂 潔, 佐々木 滉, 坂野 美紗子, 間中 友王, 林 秀大, 池田 未緒, 佐野 貴紀, 松本 諒太郎, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 中川 圭, 海野 倫明, 正宗 淳

    膵臓　39　(3)　A355-A355　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  60. 腹腔細胞診の改訂とこれからの課題 CY1膵癌に対する治療戦略のパラダイムシフト

    田中 晴祥, 平林 健一, 藤井 努, 深澤 美奈, 渋谷 和人, 大池 信之, 上野 誠, 水井 崇浩, 石田 晶玄, 江川 新一, 古川 徹, 永川 裕一, 糸井 隆夫, 北川 裕久, 眞杉 洋平, 谷 眞至, 福嶋 敬宜, 里井 壯平, 海野 倫明, 竹山 宜典

    膵臓　39　(3)　A133-A133　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  61. 【肝胆膵癌に対する集学的治療の新潮流】膵癌 切除可能膵癌への集学的治療 術前治療

    中川 圭, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 三浦 孝之, 石田 晶玄, 水間 正道, 海野 倫明

    肝胆膵　89　(1)　15-20　2024/07

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  62. 膵癌に対する術前GS化学療法 東北大学180例の実臨床データ

    前田 晋平, 水間 正道, 佐藤 英昭, 堂地 大輔, 三浦 孝之, 石田 晶玄, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　79回　1163-1163　2024/07

    Publisher: (一社)日本消化器外科学会

  63. 腹腔鏡下膵切除術の手技定型化が手術成績にもたらす効果

    佐藤 英昭, 石田 晶玄, 三浦 孝之, 堂地 大輔, 前田 晋平, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　79回　1653-1653　2024/07

    Publisher: (一社)日本消化器外科学会

  64. 胆道癌に対する集学的治療開発の現状

    中川 圭, 伊関 雅裕, 青木 修一, 佐藤 英昭, 三浦 孝之, 石田 晶玄, 水間 正道, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　79回　2241-2242　2024/07

    Publisher: (一社)日本消化器外科学会

  65. 審査腹腔鏡に関する改訂ポイントと今後の課題

    石田 晶玄, 水間 正道, 佐藤 英昭, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 中川 圭, 海野 倫明

    膵臓　39　(3)　A133-A133　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  66. 肝転移を伴った膵神経内分泌腫瘍の治療戦略 膵神経内分泌腫瘍肝転移に対する肝切除を含む集学的治療例の検討

    三浦 孝之, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    膵臓　39　(3)　A226-A226　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  67. 慢性膵炎・膵石症に対する内科的・外科的治療 慢性膵炎に対するFrey手術の成績

    佐藤 英昭, 石田 晶玄, 吉町 信吾, 志村 充広, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 中川 圭, 粂 潔, 正宗 淳, 海野 倫明

    膵臓　39　(3)　A243-A243　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  68. 術後長期生存をもたらす切除不能膵癌に対するconversion surgeryの適応基準

    青木 修一, 水間 正道, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 中川 圭, 海野 倫明

    膵臓　39　(3)　A362-A362　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  69. 膵癌術前補助化学療法におけるサルコペニアの予後への影響

    志村 充広, 水間 正道, 吉町 信吾, 佐藤 英昭, 日下 彬子, 堂地 大輔, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 石田 晶玄, 中川 圭, 海野 倫明

    膵臓　39　(3)　A373-A373　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  70. 急性膵炎の外科手術の変遷

    前田 晋平, 石田 晶玄, 吉町 信吾, 佐藤 英昭, 日下 彬子, 志村 充広, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 水間 正道, 中川 圭, 海野 倫明

    膵臓　39　(3)　A491-A491　2024/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  71. 膵癌術前補助化学療法における低骨格筋量は予後不良因子である

    志村 充広, 水間 正道, 吉町 信吾, 佐藤 英昭, 日下 彬子, 堂地 大輔, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 石田 晶玄, 中川 圭, 海野 倫明

    日本胆膵病態・生理研究会プログラム・抄録集　41回　33-33　2024/06

    Publisher: 日本胆膵病態・生理研究会

  72. 【肝門部胆管癌～診断と治療の標準化へ向けて～】外科治療:長期 術後フォローアップと補助療法

    中川 圭, 佐藤 英昭, 伊関 雅裕, 青木 修一, 日下 彬子, 堂地 大輔, 海野 倫明

    胆と膵　45　(6)　657-661　2024/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  73. 食道癌術後合併症低減のための手術手技・周術期の工夫 食道切除後の再建におけるトラブルへの工夫と対処

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    日本外科系連合学会誌　49　(3)　227-227　2024/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  74. Clonal analysis of metachronous double biliary tract cancers. International-journal

    Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Yusuke Mizukami, Toru Furukawa, Michiaki Unno

    The Journal of pathology　263　(1)　113-127　2024/05

    DOI： 10.1002/path.6265 　

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    The molecular mechanisms underpinning the development of metachronous tumors in the remnant bile duct following surgical resection of primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these mechanisms by evaluating the clinicopathologic features of BTCs, the alterations to 31 BTC-related genes on targeted sequencing, and the aberrant expression of p53, p16, SMAD4, ARID1A and β-catenin on immunohistochemistry. Twelve consecutive patients who underwent resection of metachronous BTCs following primary BTC resection with negative bile duct margins were enrolled. Among the 12 metachronous tumors, six exhibited anterograde growth in the lower portion and six exhibited retrograde growth in the upper portion of the biliary tree. Surgical resection of metachronous BTCs resulted in recurrence-free survival in seven, local recurrence in five, and death in two patients. Nine achieved 5-year overall survival after primary surgery. Molecular analyses revealed that recurrently altered genes were: TP53, SMAD4, CDKN2A, ELF3, ARID1A, GNAS, NF1, STK11, RNF43, KMT2D and ERBB3. Each of these was altered in at least three cases. A comparison of the molecular features between 12 paired primary and metachronous BTCs indicated that 10 (83%) metachronous tumors developed in clonal association with corresponding primary tumors either successionally or phylogenically. The remaining two (17%) developed distinctly. The successional tumors consisted of direct or evolved primary tumor clones that spread along the bile duct. The phylogenic tumors consisted of genetically unstable clones and conferred a poor prognosis. Metachronous tumors distinct from their primaries harbored fewer mutations than successional and phylogenic tumors. In conclusion, over 80% of metachronous BTCs that develop following primary BTC resection are probably molecularly associated with their primaries in either a successional or a phylogenetic manner. Comparison between the molecular features of a metachronous tumor and those of a preceding tumor may provide effective therapeutic clues for the treatment of metachronous BTC. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

  75. Factors affecting nonfunctioning small pancreatic neuroendocrine neoplasms and proposed new treatment strategies. International-journal

    Susumu Hijioka, Daiki Yamashige, Minoru Esaki, Goro Honda, Ryota Higuchi, Toshihiko Masui, Yasuhiro Shimizu, Masayuki Ohtsuka, Yusuke Kumamoto, Akio Katanuma, Naoto Gotohda, Hirofumi Akita, Michiaki Unno, Itaru Endo, Yukihiro Yokoyama, Suguru Yamada, Ippei Matsumoto, Takao Ohtsuka, Satoshi Hirano, Hiroaki Yasuda, Manabu Kawai, Taku Aoki, Masafumi Nakamura, Daisuke Hashimoto, Toshiki Rikiyama, Akihiko Horiguchi, Tsutomu Fujii, Shugo Mizuno, Keiji Hanada, Masaji Tani, Takashi Hatori, Tetsuhide Ito, Masataka Okuno, Shingo Kagawa, Hiroshi Tajima, Tatsuya Ishii, Motokazu Sugimoto, Shunsuke Onoe, Hideki Takami, Ryoji Takada, Takayuki Miura, Yusuke Kurita, Keiko Kamei, Yuko Mataki, Kazuichi Okazaki, Yoshifumi Takeyama, Hiroki Yamaue, Sohei Satoi

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association　2024/04/12

    DOI： 10.1016/j.cgh.2024.03.029 　

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    BACKGROUND & AIMS: Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases nonfunctioning small pNENs (NF-spNENs) in a large Japanese cohort to elucidate an optimal treatment strategy for NF-spNENs. METHODS: In this Japanese multicenter study, data were retrospectively collected from patients who underwent pancreatectomy between January 1996 and December 2019, were pathologically diagnosed with pNEN, and were treated according to the WHO 2019 classification. Overall, 1,490 patients met the eligibility criteria, and 1,014 were included in the analysis cohort. RESULTS: In the analysis cohort, 606 patients (59.8%) had NF-spNENs, with 82% classified as grade 1 (NET-G1) and 18% as grade 2 (NET-G2) or higher. The incidence of lymph node metastasis (N1) by grade was significantly higher in NET-G2 (G1: 3.1% vs. G2: 15.0%). Independent factors contributing to N1 were NET-G2 or higher and tumor diameter ≥15 mm. The predictive ability of tumor size for N1 was high. Independent factors contributing to recurrence included multiple lesions, NET-G2 or higher, tumor diameter ≥15 mm, and N1. However, the independent factor contributing to survival was tumor grade (NET-G2 or higher). The appropriate timing for surgical resection of NET-G1 and NET-G2 or higher was when tumors were >20 and >10 mm, respectively. For neoplasms with unknown preoperative grades, tumor size >15 mm was considered appropriate. CONCLUSIONS: NF-spNENs are heterogeneous with varying levels of malignancy. Therefore, treatment strategies based on tumor size alone can be unreliable; personalized treatment strategies that consider tumor grading are preferable.

  76. A case report of perihilar cholangiocarcinoma in a patient with situs inversus totalis.

    Naohiro Hirano, Masahiro Iseki, Kei Nakagawa, Masamichi Mizuma, Takashi Kamei, Ryotaro Matsumoto, Shin Miura, Kiyoshi Kume, Atsushi Masamune, Michiaki Unno

    Clinical journal of gastroenterology　2024/04/12

    DOI： 10.1007/s12328-024-01940-z 　

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    Situs inversus totalis is a rare congenital malformation in which organs are positioned in a mirror-image relationship to normal conditions. It often presents with vascular and biliary malformations. Only a few reports have pointed out the surgical difficulties in patients with situs inversus totalis, especially in those with perihilar cholangiocarcinoma. This report describes a 66-year-old male patient who underwent left hemihepatectomy (S5, 6, 7, and 8) with combined resection of the caudate lobe (S1), extrahepatic bile duct, and regional lymph nodes for perihilar cholangiocarcinoma with situs inversus totalis. Cholangiocarcinoma was mainly located in the perihilar area and progressed extensively into the bile duct. Surgery was performed after careful evaluation of the unusual anatomy. Although several vascular anomalies required delicate manipulation, the procedures were performed without major intraoperative complications. Postoperatively, bile leakage occurred, but the patient recovered with drainage treatment. The patient was discharged on the 29th postoperative day. Adjuvant chemotherapy with S-1 was administered for approximately 6 months. There was no recurrence 15 months postoperatively. Appropriate imaging studies and an understanding of unusual anatomy make surgery safe and provide suitable treatment for patients with situs inversus totalis.

  77. Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells. International-journal

    Yukihiro Sato, Minoru Kobayashi, Masahiro Ohira, Ryo Funayama, Masamitsu Maekawa, Hideaki Karasawa, Ryosuke Kashiwagi, Yayoi Aoyama, Nariyasu Mano, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama

    Cancer science　2024/04/02

    DOI： 10.1111/cas.16132 　

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    ABCC3 (also known as MRP3) is an ATP binding cassette transporter for bile acids, whose expression is downregulated in colorectal cancer through the Wnt/β-catenin signaling pathway. However, it remained unclear how downregulation of ABCC3 expression contributes to colorectal carcinogenesis. We explored the role of ABCC3 in the progression of colorectal cancer-in particular, focusing on the regulation of bile acid export. Gene expression analysis of colorectal adenoma isolated from familial adenomatous polyposis patients revealed that genes related to bile acid secretion including ABCC3 were downregulated as early as at the stage of adenoma formation. Knockdown or overexpression of ABCC3 increased or decreased intracellular concentration of deoxycholic acid, a secondary bile acid, respectively, in colorectal cancer cells. Forced expression of ABCC3 suppressed deoxycholic acid-induced activation of MAPK signaling. Finally, we found that nonsteroidal anti-inflammatory drugs increased ABCC3 expression in colorectal cancer cells, suggesting that ABCC3 could be one of the targets for therapeutic intervention of familial adenomatous polyposis. Our data thus suggest that downregulation of ABCC3 expression contributes to colorectal carcinogenesis through the regulation of intracellular accumulation of bile acids and activity of MAPK signaling.

  78. 膵手術における合併症対策のエビデンス Blumgart法による膵空腸吻合部の長期開存性に関する検討

    石田 晶玄, 大塚 英郎, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 中川 圭, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　PD-3　2024/04

    Publisher: (一社)日本外科学会

  79. 局所進行膵癌に対するconversion surgeryの治療戦略と治療成績

    前田 晋平, 水間 正道, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-3　2024/04

    Publisher: (一社)日本外科学会

  80. 肝胆膵外科高度技能専門医の育成と伝承

    中川 圭, 吉町 信吾, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-8　2024/04

    Publisher: (一社)日本外科学会

  81. 高齢者肝門部領域胆管癌に対する肝葉切除において術前Glasgow Prognostic Score高値が周術期死亡のリスク因子となる

    國米 崇, 中川 圭, 青木 修一, 伊関 雅裕, 佐藤 英昭, 日下 彬子, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-3　2024/04

    Publisher: (一社)日本外科学会

  82. 肝門部領域胆管癌における術後短期成績改善に向けた取り組み

    青木 修一, 中川 圭, 伊関 雅裕, 國米 崇, 佐藤 英昭, 日下 彬子, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-5　2024/04

    Publisher: (一社)日本外科学会

  83. 当院におけるbiliary IOPN 10切除例の臨床病理学的検討

    日下 彬子, 青木 修一, 伊藤 泰斗, 大森 優子, 國米 崇, 佐藤 英昭, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宣, 古川 徹, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-4　2024/04

    Publisher: (一社)日本外科学会

  84. 遺伝子パネル検査による胆道癌治療の変化と現状

    佐藤 英昭, 中川 圭, 青木 修一, 伊関 雅裕, 國米 崇, 日下 彬子, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-6　2024/04

    Publisher: (一社)日本外科学会

  85. Conversion手術を目指した腹腔細胞診陽性膵癌に対する集学的治療

    伊関 雅裕, 水間 正道, 日下 彬子, 國米 崇, 佐藤 英昭, 青木 修一, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-4　2024/04

    Publisher: (一社)日本外科学会

  86. 膵・胆道癌患者と非担癌患者における腸内細菌叢分布の比較と薬物治療効果予測因子の探索

    平野 直大, 青木 修一, 國米 崇, 佐藤 英昭, 日下 彬子, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宜, 阿部 高明, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　PS-3　2024/04

    Publisher: (一社)日本外科学会

  87. 【消化器良性疾患に対する外科治療update】肝胆膵 慢性膵炎・膵石症に対する外科治療update

    佐藤 英昭, 石田 晶玄, 水間 正道, 海野 倫明

    外科　86　(4)　377-381　2024/04

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  88. 膵癌に対する術前治療における画像上の腫瘍縮小率およびCA19-9の変化率と組織学的効果判定基準との乖離

    堂地 大輔, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　PS-2　2024/04

    Publisher: (一社)日本外科学会

  89. Sustainableな肝胆膵・移植外科の未来を考える Z世代を肝移植に引き込むために 大講座の肝胆膵外科の医局長が考えていること

    藤尾 淳, 戸子台 和哲, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 三頭 啓明, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　WS-1　2024/04

    Publisher: (一社)日本外科学会

  90. 孤立性前縦隔リンパ節転移を来した肝内胆管癌の1例

    谷口 毅樹, 齊藤 竜助, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 三頭 啓明, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　RS-3　2024/04

    Publisher: (一社)日本外科学会

  91. マージナルドナーからの臓器提供を生かした脳死肝移植ドナー数増加の試み

    佐藤 怜, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 三頭 啓明, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　RS-2　2024/04

    Publisher: (一社)日本外科学会

  92. 膵腎同時移植後にGVHDを発症したHLA型一方向性0ミスマッチの一症例

    小林 紗也, 松村 宗幸, 関 修, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 三頭 啓明, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　RS-4　2024/04

    Publisher: (一社)日本外科学会

  93. 肛門近傍の下部直腸癌における前壁病変は腹腔鏡下術の局所再発危険因子となり得る/ULTIMATE study副次研究

    神山 篤史, 大沼 忍, 海野 倫明, 伊藤 雅昭, 塚田 祐一郎, 内藤 剛, 渡邊 昌彦

    日本外科学会定期学術集会抄録集　124回　SF-8　2024/04

    Publisher: (一社)日本外科学会

  94. 肝臓におけるeR1活性幹細胞の同定とその役割

    佐々木 啓迪, 山村 明寛, 岡本 浩二, 添田 敏寛, 川名 友美, 杉沢 徳彦, 土屋 尭裕, 井本 博文, 田中 直樹, 西條 文人, 中川 圭, 大沼 忍, 亀井 尚, 石田 孝宣, 伊藤 嘉明, 大里 元美, 海野 倫明

    日本外科学会定期学術集会抄録集　124回　SF-8　2024/04

    Publisher: (一社)日本外科学会

  95. ロボット支援食道手術における短中期成績 ロボット支援下食道切除における短期・中期成績の検討と今後への展望

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 八嶋 嘉之, 金淵 佐和, 角掛 純一, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　SY-2　2024/04

    Publisher: (一社)日本外科学会

  96. 食道胃接合部腺癌に対する集学的治療 高度進行食道胃接合部腺癌に対するconversion surgeryも見据えた導入化学療法後切除症例の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 篠崎 康晴, 大沼 忍, 海野 倫明, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　SY-6　2024/04

    Publisher: (一社)日本外科学会

  97. 上部消化管外科におけるロボット手術のトラブルシューティング(ヒヤリハットを含む) ロボット支援低侵襲食道切除術における偶発症

    佐藤 千晃, 角掛 純一, 金淵 佐和, 八嶋 嘉之, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　WS-7　2024/04

    Publisher: (一社)日本外科学会

  98. ロボット支援食道手術における短中期成績 ロボット支援下食道切除における短期・中期成績の検討と今後への展望

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 八嶋 嘉之, 金淵 佐和, 角掛 純一, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　SY-2　2024/04

    Publisher: (一社)日本外科学会

  99. 食道胃接合部腺癌に対する集学的治療 高度進行食道胃接合部腺癌に対するconversion surgeryも見据えた導入化学療法後切除症例の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 篠崎 康晴, 大沼 忍, 海野 倫明, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　SY-6　2024/04

    Publisher: (一社)日本外科学会

  100. 上部消化管外科におけるロボット手術のトラブルシューティング(ヒヤリハットを含む) ロボット支援低侵襲食道切除術における偶発症

    佐藤 千晃, 角掛 純一, 金淵 佐和, 八嶋 嘉之, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　124回　WS-7　2024/04

    Publisher: (一社)日本外科学会

  101. Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity. International-journal

    Yuki Ishikawa, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kazuaki Tokodai, Fumiyoshi Fujishima, Shin Kawanabe, Takuyuki Katabami, Akira Ikeya, Miho Yamashita, Yutaka Oki, Hiroshi Nanjo, Fumitoshi Satoh, Akihiro Ito, Michiaki Unno, Takashi Kamei, Hironobu Sasano, Takashi Suzuki

    The Journal of steroid biochemistry and molecular biology　238　106462-106462　2024/04

    DOI： 10.1016/j.jsbmb.2024.106462 　

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    Adrenocortical carcinoma (ACC) patients with glucocorticoid excess have been reported to be associated with decreased tumor-infiltrating immune cells, but the effects of in situ glucocorticoid production on tumor immunity have remained unknown. In addition, ACC was also known to harbor marked intra-tumoral heterogeneity of steroidogenesis or disorganized steroidogenesis. Therefore, in this study, we immune-profiled tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) and pivotal steroidogenic enzymes of glucocorticoid biosynthesis (CYP17A and CYP11B1) to explore the potential effects of in situ glucocorticoid production and intra-tumoral heterogeneity/disorganized steroidogenesis on tumor immunity of ACC. We also studied the correlations of the status of tumor immunity with that of angiogenesis and tumor grade to further explore the tumor tissue microenvironment of ACC. TILs (CD3, CD4, CD8, and FOXP3), TAMs (CD68 and CD163), key steroidogenic enzymes of glucocorticoid (CYP17A and CYP11B1), angiogenesis (CD31 and vasohibin-1 (VASH-1)), tumor grade (Ki-67 and Weiss score) were immunohistochemically evaluated in 34 ACCs. Increased CYP17A immunoreactivity in the whole tumor area was significantly positively correlated with FOXP3-positive TILs (p = 0.021) and negatively with CD4/CD3 ratio (p = 0.001). Increased CYP11B1 immunoreactivity in the whole tumor area was significantly positively correlated with CD8/CD3 (p = 0.039) and CD163/CD68 ratios (p = 0.006) and negatively with CD4-positive TILs (p = 0.036) and CD4/CD3 ratio (p = 0.001). There were also significant positive correlations between CYP17A and CD8 (r = 0.334, p < 0.001) and FOXP3-positive TILs (r = 0.414, p < 0.001), CD8/CD3 ratio (r = 0.421, p < 0.001), and CD68-positive TAMs (r = 0.298, p < 0.001) in randomly selected areas. Significant positive correlations were also detected between CYP11B1 and CD8/CD3 ratio (r = 0.276, p = 0.001) and negative ones detected between CYP11B1 and CD3- (r = -0.259, p = 0.002) and CD4-positive TILs (r = -0.312, p < 0.001) in those areas above. Increased micro-vessel density (MVD) -VASH-1 was significantly positively correlated with CD68- (p = 0.015) and CD163-positive TAMs (p = 0.009) and CD163/CD68 ratio and the high VASH-1 with CD163-positive TAMs (p = 0.042). Ki-67 labeling index was significantly positively correlated with MAD-VASH-1 (p = 0.006) and VASH-1 (p = 0.006) status. Results of our present study indicated that in situ glucocorticoid production did influence the status of tumor immunity in ACC. In particular, increased levels of CYP17A and CYP11B1, both involved in glucocorticoid producing immunoreactivity played different effects on tumor immunity, i.e., reflecting the involvement of intra-tumoral heterogeneity and disorganized steroidogenesis of ACC, which also did indicate the importance of in situ approaches when analyzing tumor immunity of ACC.

  102. がんゲノム医療の次のステップ 転移再発乳癌におけるがん遺伝子パネル検査の成績と今後の展望

    多田 寛, 宮下 穣, 原田 成美, 江幡 明子, 濱中 洋平, 佐藤 未来, 本成 登喜和, 柳垣 美歌, 昆 智美, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 石田 孝宣

    日本外科学会定期学術集会抄録集　124回　WS-7　2024/04

    Publisher: (一社)日本外科学会

  103. De novo Stage IV乳癌における乳房術後放射線療法の有効性の検証

    宮下 穣, 多田 寛, 原田 成美, 江幡 明子, 濱中 洋平, 佐藤 未来, 本成 登喜和, 柳垣 美歌, 昆 智美, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 石田 孝宣

    日本外科学会定期学術集会抄録集　124回　SF-7　2024/04

    Publisher: (一社)日本外科学会

  104. Rupture of ectopic varices of the ascending colon occurring after pancreatic cancer surgery: A case report and literature review. International-journal

    Yushi Inomata, Takeo Naito, Takashi Hiratsuka, Yusuke Shimoyama, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Kimiko Kayada, Yuki Ohara, Naoki Asano, Shuichi Aoki, Michiaki Unno, Atsushi Masamune

    DEN open　4　(1)　e255　2024/04

    DOI： 10.1002/deo2.255 　

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    A 69-year-old woman, a long-term survivor of subtotal stomach-preserving pancreatoduodenectomy with the splenic vein resection for pancreatic cancer, visited our hospital with a chief complaint of bloody stools. Previously, she was diagnosed with varices in the ascending colon due to left-sided portal hypertension after pancreatoduodenectomy by computed tomography and colonoscopy. After emergency hospitalization, she went into shock, and blood tests showed acute progression of severe anemia. Computed tomography showed a mosaic-like fluid accumulation from the ascending colon to the rectum. She was diagnosed with ruptured varices in the ascending colon. Emergency colonoscopy was performed, and treatment with endoscopic injection sclerotherapy using N-butyl-2-cyanoacrylate was successful. Ectopic varices occur at any location other than the esophagus and stomach, and colonic varices are rare among them. They are mostly caused by portal hypertension due to liver cirrhosis. However, with the trend of improving the prognosis for patients with pancreatic cancer, we should occasionally pay attention to the development of ectopic varices including colonic varices in patients who have undergone pancreatoduodenectomy with superior mesenteric and splenic veins resection. Treatment methods for colonic varices varied from case to case, including conservative therapy, interventional radiology, and endoscopic procedure. In this case, endoscopic injection sclerotherapy was successfully performed without any complications. To the best of our knowledge, this is the first study to report successful treatment with endoscopic injection sclerotherapy for varices in the ascending colon caused by left-sided portal hypertension after pancreatoduodenectomy. Colonic varices should be considered in patients with obscure gastrointestinal bleeding after pancreatoduodenectomy.

  105. The Significance of Bile in the Biliopancreatic Limb on Metabolic Improvement After Duodenal-Jejunal Bypass. International-journal

    Tomomi Kawana, Hirofumi Imoto, Naoki Tanaka, Takahiro Tsuchiya, Akihiro Yamamura, Fumito Saijo, Masamitsu Maekawa, Toru Tamahara, Ritsuko Shimizu, Kei Nakagawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Obesity surgery　2024/03/21

    DOI： 10.1007/s11695-024-07176-7 　

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    INTRODUCTION: Duodenal-jejunal bypass (DJB) is an experimental procedure in metabolic surgery that does not have a restrictive component. Changes in bile acid (BA) dynamics and intestinal microbiota are possibly related to metabolic improvement after DJB. Our previous studies involving obese diabetic rats showed the crucial role of the biliopancreatic limb (BPL) in metabolic improvement after DJB caused by BA reabsorption. We established a new DJB procedure to prevent bile from flowing into the BPL and aimed to elucidate the importance of bile in the BPL after DJB. METHODS: Otsuka Long-Evans Tokushima Fatty rats with diabetes were divided into three groups: two DJB groups and a sham group (n = 11). Duodenal-jejunal anastomosis was performed proximal to the papilla of Vater in the DJB group (n = 11). However, the DJB-D group (n = 11) underwent a new procedure with duodenal-jejunal anastomosis distal to the papilla of Vater for preventing bile flow into the BPL. RESULTS: Glucose metabolism improved and weight gain was suppressed in the DJB group, but not in the DJB-D and sham groups. Serum BA level and conjugated BA concentration were elevated in the DJB group. The gut microbiota was altered only in the DJB group; the abundance of Firmicutes and Bacteroidetes decreased and that of Actinobacteria increased. However, the DJB-D group exhibited no apparent change in the gut microbiota, similar to the sham group. CONCLUSION: BAs are essential in the BPL for metabolic improvement after DJB; they can improve the gut microbiota in these processes.

  106. Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?

    Seiko Hirono, Ryota Higuchi, Goro Honda, Satoshi Nara, Minoru Esaki, Naoto Gotohda, Hideki Takami, Michiaki Unno, Teiichi Sugiura, Masayuki Ohtsuka, Yasuhiro Shimizu, Ippei Matsumoto, Toshifumi Kin, Hiroyuki Isayama, Daisuke Hashimoto, Yasuji Seyama, Hiroaki Nagano, Kenichi Hakamada, Satoshi Hirano, Yuichi Nagakawa, Shugo Mizuno, Hidenori Takahashi, Kazuto Shibuya, Hideki Sasanuma, Taku Aoki, Yuichiro Kohara, Toshiki Rikiyama, Masafumi Nakamura, Itaru Endo, Yoshihiro Sakamoto, Akihiko Horiguchi, Takashi Hatori, Hirofumi Akita, Toshiharu Ueki, Tetsuya Idichi, Keiji Hanada, Shuji Suzuki, Keiichi Okano, Hiromitsu Maehira, Fuyuhiko Motoi, Yasuhiro Fujino, Satoshi Tanno, Akio Yanagisawa, Yoshifumi Takeyama, Kazuichi Okazaki, Sohei Satoi, Hiroki Yamaue

    Annals of Gastroenterological Surgery　2024/03/17

    Publisher: Wiley

    DOI： 10.1002/ags3.12790 　

    ISSN： 2475-0328

    eISSN： 2475-0328

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    Abstract Background Surgical resection is standard treatment for invasive intraductal papillary mucinous carcinoma (IPMC); however, impact of multidisciplinary treatment on survival including postoperative adjuvant therapy (AT), neoadjuvant therapy (NAT), and treatment for recurrent lesions is unclear. We investigated the effectiveness of multidisciplinary treatment in prolonging survival of patients with invasive IPMC. Methods This retrospective multi‐institutional study included 1183 patients with invasive IPMC undergoing surgery at 40 academic institutions. We analyzed the effects of AT, NAT, and treatment for recurrence on survival of patients with invasive IPMC. Results Completion of the planned postoperative AT for 6 months improved the overall survival (OS), disease‐specific survival (DSS), and recurrence‐free survival (RFS) of patients with stage IIB and stage III resected invasive IPMC, elevated preoperative carbohydrate antigen 19–9 level, lymphovascular invasion, perineural invasion, serosal invasion, and lymph node metastasis on un‐matched and matched analyses. Of the patients with borderline resectable (BR) invasive IPMC, the OS (p = 0.001), DSS (p = 0.001), and RFS (p = 0.001) of patients undergoing NAT was longer than that of those without on the matched analysis. Of the 484 invasive IPMC patients (40.9%) who developed recurrence after surgery, the OS of 365 patients who received any treatment for recurrence was longer than that of those without treatment (40.6 vs. 22.4 months, p &lt; 0.001). Conclusion Postoperative AT might benefit selected patients with invasive IPMC, especially those at high risk of poor survival. NAT might improve the survivability of BR invasive IPMC. Any treatment for recurrence after surgery for invasive IPMC might improve survival.

  107. A Recombinant Peptide Device Combined with Adipose Tissue-Derived Stem Cells Enhances Subcutaneous Islet Engraftment. International-journal

    Takahiro Mizui, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Satomi Suzuki Uematsu, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Masafumi Goto

    Cells　13　(6)　2024/03/13

    DOI： 10.3390/cells13060499 　

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    Subcutaneous space has been considered an attractive site for islet graft transplantation; however, the oxygen tension and vascularization are insufficient for islet graft survival. We investigated whether subcutaneous pre-implantation of a recombinant peptide (RCP) device with adipose tissue-derived stem cells (ADSCs) enhanced subcutaneous islet engraftment. RCP devices with/without syngeneic ADSCs were pre-implanted into the subcutaneous space of C57BL/6 mice. Syngeneic islets (300 or 120 islet equivalents (IEQs)) were transplanted into the pre-treated space after diabetes induction using streptozotocin. The cure rates of groups in which RCP devices were implanted four weeks before transplantation were significantly better than the intraportal transplantation group when 300 IEQs of islets were transplanted (p < 0.01). The blood glucose changes in the RCP+ADSCs-4w group was significantly ameliorated in comparison to the RCP-4w group when 120 IEQs of islets were transplanted (p < 0.01). Immunohistochemical analyses showed the collagen III expression in the islet capsule of the RCP+ADSCs-4w group was significantly enhanced in comparison to the RCP-4w and RCP+ADSCs-d10 groups (p < 0.01, p < 0.01). In addition, the number of von Willebrand factor-positive vessels within islets in the RCP+ADSCs-4w group was significantly higher than the RCP-4w group. These results suggest that using ADSCs in combination with an RCP device could enhance the restoration of the extracellular matrices, induce more efficient prevascularization within islets, and improve the graft function.

  108. FAXC interacts with ANXA2 and SRC in mitochondria and promotes tumorigenesis in cholangiocarcinoma. International-journal

    Haruna Fujimori, Mao Shima-Nakamura, Shin-Ichiro Kanno, Rie Shibuya-Takahashi, Mai Mochizuki, Masamichi Mizuma, Michiaki Unno, Yuta Wakui, Makoto Abue, Wataru Iwai, Daisuke Fukushi, Kennich Satoh, Kazunori Yamaguchi, Norihisa Shindo, Jun Yasuda, Keiichi Tamai

    Cancer science　2024/03/13

    DOI： 10.1111/cas.16140 　

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    Cholangiocarcinoma (CCA) is one of the most difficult malignancies to treat as the therapeutic options are limited. Although several driver genes have been identified, most remain unknown. In this study, we identified a failed axon connection homolog (FAXC), whose function is unknown in mammals, by analyzing serially passaged CCA xenograft models. Knockdown of FAXC reduced subcutaneous tumorigenicity in mice. FAXC was bound to annexin A2 (ANXA2) and c-SRC, which are tumor-promoting genes. The FAXC/ANXA2/c-SRC complex forms in the mitochondria. FAXC enhances SRC-dependent ANXA2 phosphorylation at tyrosine-24, and the C-terminal amino acid residues (351-375) of FAXC are required for ANXA2 phosphorylation. Transcriptome data from a xenografted CCA cell line revealed that FAXC correlated with epithelial-mesenchymal transition, hypoxia, and KRAS signaling genes. Collectively, these findings advance our understanding of CCA tumorigenesis and provide candidate therapeutic targets.

  109. 膵癌早期診断の試み 高異型度PanIN/膵上皮内癌・小径膵癌の分子進化モデル

    伊藤 泰斗, 大森 優子, 高橋 賢治, 國米 崇, 正宗 淳, 海野 倫明, 水上 裕輔, 古川 徹

    日本消化器病学会雑誌　121　(臨増総会)　A219-A219　2024/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  110. 肝門部領域胆管癌肝予備能不良症例に化学療法と二期的門脈塞栓を併用した切除経験

    中川 圭, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 大沼 忍, 海野 倫明

    日本消化器病学会雑誌　121　(臨増総会)　A403-A403　2024/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  111. Blood flow ratio in the gastric conduit measured by laser Doppler flowmetry: A predictor of anastomotic leakage after esophagectomy Peer-reviewed

    Hirotaka Ishida, Toshiaki Fukutomi, Yusuke Taniyama, Chiaki Sato, Hiroshi Okamoto, Yohei Ozawa, Yu Onodera, Ken Koseki, Michiaki Unno, Takashi Kamei

    Annals of Gastroenterological Surgery　2024/03

    DOI： 10.1002/ags3.12754 　

  112. Molecular pathological demonstration of an unusual angiosarcoma-like dedifferentiation pattern in hepatocellular carcinoma. International-journal

    Keigo Murakami, Taito Itoh, Yasunobu Okamura, Kengo Kinoshita, Hideki Ota, Michiaki Unno, Takashi Kamei, Toru Furukawa

    Pathology international　2024/02/06

    DOI： 10.1111/pin.13412 　

  113. 機械学習による膵癌病理組織を用いた術後膵癌の再発予測

    山口 るり, 森川 啓, 赤塚 純, 沼田 康志, 水間 正道, 海野 倫明, 三宅 顕光, 田宮 元, 山本 陽一朗, 古川 徹

    日本病理学会会誌　113　(1)　400-400　2024/02

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  114. ディープラーニングによる腹腔洗浄細胞診標本を用いた膵癌患者の予後予測(Deep learning predicts the prognosis of pancreatic cancer patients using peritoneal washing cytology)

    野口 彩, 沼田 康志, 菅原 隆譲, 三浦 弘守, 石田 晶玄, 堂地 大輔, 前田 一郎, 海野 倫明, 山本 陽一朗, 古川 徹

    日本病理学会会誌　113　(1)　282-282　2024/02

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  115. 高異型度PanIN/膵上皮内癌・小径膵癌の分子進化モデル(Molecular evolutionary model of early pancreatic cancer)

    伊藤 泰斗, 大森 優子, 小野 裕介, 高橋 賢治, 岡村 容伸, 木下 賢吾, 正宗 淳, 海野 倫明, 水上 裕輔, 古川 徹

    日本病理学会会誌　113　(1)　318-318　2024/02

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  116. 肝胆膵がん診療の現状と今後の課題 進行胆道癌に対するConversion手術

    伊関 雅裕, 中川 圭, 青木 修一, 佐藤 英昭, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　216回　61-61　2024/02

    Publisher: 日本消化器病学会-東北支部

  117. Open abdomen managementにより治療した仮性動脈瘤破裂を伴う十二指腸穿孔の1例

    森田 隆之, 佐藤 武揚, 青木 修一, 國米 崇, 吉町 信吾, 佐藤 英昭, 日下 彬子, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 久志本 成樹, 海野 倫明

    日本腹部救急医学会雑誌　44　(2)　408-408　2024/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  118. 若年者大腸癌の臨床病理学的特徴

    小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　77　(2)　134-134　2024/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  119. 230例の経験から検討する食道アカラシアの早期診断のための工夫

    邑並 祐人, 佐藤 千晃, 谷山 裕亮, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 八嶋 嘉之, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　216回　93-93　2024/02

    Publisher: 日本消化器病学会-東北支部

  120. 腹部救急・重症患者診療における代謝栄養管理を考える 当院での食道癌周術期代謝栄養管理の取り組み 術後合併症低減・回復促進・予後向上を目指して

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 篠崎 康晴, 大沼 忍, 海野 倫明, 亀井 尚

    日本腹部救急医学会雑誌　44　(2)　301-301　2024/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  121. 高異型度PanIN/膵上皮内癌・小径膵癌の分子進化モデル(Molecular evolutionary model of early pancreatic cancer)

    伊藤 泰斗, 大森 優子, 小野 裕介, 高橋 賢治, 岡村 容伸, 木下 賢吾, 正宗 淳, 海野 倫明, 水上 裕輔, 古川 徹

    日本病理学会会誌　113　(1)　318-318　2024/02

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  122. 胃管癌に対する治療成績

    佐藤 千晃, 八嶋 嘉之, 金淵 佐和, 角掛 純一, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本胃癌学会総会記事　96回　384-384　2024/02

    Publisher: (一社)日本胃癌学会

  123. 230例の経験から検討する食道アカラシアの早期診断のための工夫

    邑並 祐人, 佐藤 千晃, 谷山 裕亮, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 八嶋 嘉之, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　216回　93-93　2024/02

    Publisher: 日本消化器病学会-東北支部

  124. 腹部救急・重症患者診療における代謝栄養管理を考える 当院での食道癌周術期代謝栄養管理の取り組み 術後合併症低減・回復促進・予後向上を目指して

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 篠崎 康晴, 大沼 忍, 海野 倫明, 亀井 尚

    日本腹部救急医学会雑誌　44　(2)　301-301　2024/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  125. 胃原発胎児消化管類似癌の3例

    陳 梦格, 土屋 尭裕, 井本 博文, 田中 直樹, 山崎 有人, 鈴木 貴, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　85　(1)　38-43　2024/01

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  126. A Gelatin Hydrogel Nonwoven Fabric Combined With Adipose Tissue-Derived Stem Cells Enhances Subcutaneous Islet Engraftment. International-journal

    Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo Kumata, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

    Cell transplantation　33　9636897241251621-9636897241251621　2024

    DOI： 10.1177/09636897241251621 　

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    Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet engraftment. We herein investigated whether the addition of adipose tissue-derived stem cells (ADSCs) to GHNF affected the outcome. A silicone spacer sandwiched between two GHNFs with (AG group) or without (GHNF group) ADSCs, or a silicone spacer alone (Silicone group) was implanted into the subcutaneous space of healthy mice at 6 weeks before transplantation, then diabetes was induced 7 days before transplantation. Syngeneic islets were transplanted into the pretreated space. Intraportal transplantation (IPO group) was also performed to compare the transplant efficiency. Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, and inflammatory mediators were evaluated. The results in the subcutaneous transplantation were compared using the Silicone group as a control. The results of the IPO group were also compared with those of the AG group. The AG group showed significantly better blood glucose changes than the Silicone and the IPO groups. The cure rate of AG group (72.7%) was the highest among the groups (GHNF; 40.0%, IPO; 40.0%, Silicone; 0%). The number of vWF-positive vessels in the subcutaneous space of the AG group was significantly higher than that in other groups before transplantation (P < 0.01). Lectin angiography also showed that the same results (P < 0.05). According to the results of the ADSCs tracing, ADSCs did not exist at the transplant site (6 weeks after implantation). The positive rates for laminin and collagen III constructed around the transplanted islets did not differ among groups. Inflammatory mediators were higher in the Silicone group, followed by the AG and GHNF groups. Pretreatment using bioabsorbable scaffolds combined with ADSCs enhanced neovascularization in subcutaneous space, and subcutaneous islet transplantation using GHNF with ADSCs was superior to intraportal islet transplantation.

  127. 胃原発胎児消化管類似癌の3例

    陳 梦格, 土屋 尭裕, 井本 博文, 田中 直樹, 山崎 有人, 鈴木 貴, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　85　(1)　38-43　2024/01

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  128. Revascularization and Digestive Tract Repair in Secondary Aortoenteric Fistula Using a Single-center In situ Revascularization Strategy. International-journal

    Daijirou Akamatsu, Fukashi Serizawa, Michihisa Umetsu, Shunya Suzuki, Hitoshi Goto, Michiaki Unno, Takashi Kamei

    Annals of vascular surgery　2023/12/28

    DOI： 10.1016/j.avsg.2023.10.028 　

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    OBJECTIVE: Information regarding optimal revascularization and digestive tract repair in secondary aortoenteric fistula (sAEF) remains unclear. Thus, reporting treatment outcomes and presenting comprehensive patient details through a structured treatment approach are necessary to establish a treatment strategy for this rare, complex, and fatal condition. METHODS: We performed a single-center retrospective review of consecutive sAEF managed based on our in situ revascularization (ISR) and intestinal repair strategy. The primary endpoint of this study was all-cause mortality, and secondary endpoints were the incidence of in-hospital complications and midterm reinfections. RESULTS: Between 2007 and 2020, 16 patients with sAEF, including 13 men (81%), underwent ISR and digestive tract repair. The median follow-up duration for all participants was 36 (interquartile range, 6-62) months. Among the participants, 81% (n = 13), 13% (n = 2), and 6% (n = 1) underwent aortic reconstruction with rifampin-soaked grafts, unsoaked Dacron grafts, and femoral veins, respectively. The duodenum was the most commonly involved site in enteric pathology (88%; n = 14), and 57% (n = 8) of duodenal breaks were repaired by a simple closure. Duodenum second part-jejunum anastomosis was performed in 43% of patients (n = 6), and perioperatively, 19% of the patients (n = 3) died. In-hospital complications occurred in 88% patients (n = 14), and the most frequent complication was gastrointestinal. Finally, 81% patients (n = 13) were discharged home. Oral antibiotics were administered for a median duration of 5.7 months postoperatively; subsequently, the participants were followed up carefully. Reinfection was detected in 6% of the patients (n = 1) who underwent reoperation without any complications. The 1- and 3-year overall survival rates of participants were 75% (n = 12) and 75% (n = 9), respectively, and no sAEF-related deaths occurred, except perioperative death. CONCLUSIONS: Surgical intervention with contemporary management based on our vascular strategy and digestive tract procedure may be a durable treatment for sAEF.

  129. A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats. International-journal

    Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo Kumata, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

    Cells　13　(1)　2023/12/26

    DOI： 10.3390/cells13010051 　

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    Although subcutaneous islet transplantation has many advantages, the subcutaneous space is poor in vessels and transplant efficiency is still low in animal models, except in mice. Subcutaneous islet transplantation using a two-step approach has been proposed, in which a favorable cavity is first prepared using various materials, followed by islet transplantation into the preformed cavity. We previously reported the efficacy of pretreatment using gelatin hydrogel nonwoven fabric (GHNF), and the length of the pretreatment period influenced the results in a mouse model. We investigated whether the preimplantation of GHNF could improve the subcutaneous islet transplantation outcomes in a rat model. GHNF sheets sandwiching a silicone spacer (GHNF group) and silicone spacers without GHNF sheets (control group) were implanted into the subcutaneous space of recipients three weeks before islet transplantation, and diabetes was induced seven days before islet transplantation. Syngeneic islets were transplanted into the space where the silicone spacer was removed. Blood glucose levels, glucose tolerance, immunohistochemistry, and neovascularization were evaluated. The GHNF group showed significantly better blood glucose changes than the control group (p < 0.01). The cure rate was significantly higher in the GHNF group (p < 0.05). The number of vWF-positive vessels was significantly higher in the GHNF group (p < 0.01), and lectin angiography showed the same tendency (p < 0.05). The expression of laminin and collagen III around the transplanted islets was also higher in the GHNF group (p < 0.01). GHNF pretreatment was effective in a rat model, and the main mechanisms might be neovascularization and compensation of the extracellular matrices.

  130. Machine Learning of Histopathological Images Predicts Recurrences of Resected Pancreatic Ductal Adenocarcinoma With Adjuvant Treatment

    Ruri Yamaguchi, Hiromu Morikawa, Jun Akatsuka, Yasushi Numata, Aya Noguchi, Takashi Kokumai, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Akimitsu Miyake, Gen Tamiya, Yoichiro Yamamoto, Toru Furukawa

    Pancreas　2023/12/21

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/mpa.0000000000002289 　

    ISSN： 0885-3177

    eISSN： 1536-4828

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    Objectives Pancreatic ductal adenocarcinoma is an intractable disease with frequent recurrence after resection and adjuvant therapy. The present study aimed to clarify whether artificial intelligence–assisted analysis of histopathological images can predict recurrence in patients with pancreatic ductal adenocarcinoma who underwent resection and adjuvant chemotherapy with tegafur/5-chloro-2,4-dihydroxypyridine/potassium oxonate. Materials and Methods Eighty-nine patients were enrolled in the study. Machine-learning algorithms were applied to 10-billion-scale pixel data of whole-slide histopathological images to generate key features using multiple deep autoencoders. Areas under the curve were calculated from receiver operating characteristic curves using a support vector machine with key features alone and by combining with clinical data (age and carbohydrate antigen 19-9 and carcinoembryonic antigen levels) for predicting recurrence. Supervised learning with pathological annotations was conducted to determine the significant features for predicting recurrence. Results Areas under the curves obtained were 0.73 (95% confidence interval, 0.59–0.87) by the histopathological data analysis and 0.84 (95% confidence interval, 0.73–0.94) by the combinatorial analysis of histopathological data and clinical data. Supervised learning model demonstrated that poor tumor differentiation was significantly associated with recurrence. Conclusions Results indicate that machine learning with the integration of artificial intelligence–driven evaluation of histopathological images and conventional clinical data provides relevant prognostic information for patients with pancreatic ductal adenocarcinoma.

  131. Small Intestinal Adenocarcinoma Arising at the Anastomotic Site after Kasai Operation for Biliary Atresia: A Case Report and Literature Review.

    Yuki Ishikawa, Ryusuke Saito, Keigo Murakami, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Kazuki Degawa, Yoshinobu Kobayashi, Ryo Muto, Kazuaki Tokodai, Toru Furukawa, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　261　(4)　267-272　2023/12/16

    DOI： 10.1620/tjem.2023.J080 　

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    Biliary atresia is an obliterative cholangiopathy of unknown etiology. Hepatic portoenterostomy, in which obliterated extrahepatic bile ducts are resected and bile flow is restored, known as Kasai operation, is performed within 3 months after birth. While this operation enhances long-term survival of patients, the occurrence of primary malignant hepatic tumors has been increasing. We report a case of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation. A 49-year-old man, who underwent Kasai operation for biliary atresia when he was 2 months old, experienced rapidly progressive jaundice and liver dysfunction. Deceased-donor liver transplantation was performed for liver failure. Macroscopically, there was a white-yellow tumor located at the anastomotic site of hepatic portoenterostomy of the resected liver. Pathological examination revealed a well-differentiated adenocarcinoma with some Paneth cells in the neoplastic lesion. Immunohistochemically, the tumor cells were negative for cytokeratin 7 (CK7) but positive for cytokeratin 20 (CK20) and a homeobox domain-containing transcription factor (CDX2). Mucin expression in tumor cells was negative for mucin 1 (MUC1) and mucin 6 (MUC6) and positive for mucin 2 (MUC2) and mucin 5AC (MUC5AC). The pathological diagnosis was small intestinal adenocarcinoma originating from the jejunum. The patient was discharged 48 days after the operation. The patient had not experienced recurrence at 10 months after the operation. This is the first report of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation for biliary atresia. Special care should be taken for the patients after Kasai operation with acute progressive jaundice and liver dysfunction because there is a possibility of malignancy in their native liver.

  132. 低侵襲膵切除術に必要なprecision anatomy 腹腔鏡下膵尾側切除術におけるトライツ靱帯および周囲組織の解剖・組織学的検討

    石田 晶玄, 三浦 孝之, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　155-155　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  133. 当科における低侵襲膵体尾部切除術の成績

    三浦 孝之, 石田 晶玄, 森川 孝則, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 大塚 英郎, 水間 正道, 中川 圭, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　1721-1721　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  134. 術前化学療法後膵癌に対する腹腔鏡下膵体尾部切除術の成績

    國米 崇, 石田 晶玄, 三浦 孝之, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 大塚 英郎, 水間 正道, 中川 圭, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　2101-2101　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  135. 【地域でのストーマ・排泄ケア教育】東北ストーマリハビリテーション講習会における看護師講師の人材育成

    高橋 真紀, 神山 篤史, 齋藤 優紀子, 渡邊 涼子, 熊谷 英子, 柴崎 真澄, 海野 倫明, 東北ストーマリハビリテーション講習会

    日本ストーマ・排泄リハビリテーション学会誌　39　(3)　121-124　2023/12

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  136. 高度進行食道癌に対する低侵襲手術 鏡視下食道切除術を施行したcT3症例の再検討と部位別T3Br症例の短長期成績

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 金淵 佐和, 邑並 祐人, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　144-144　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  137. 腹腔鏡下Nissen噴門形成術後の再々発に対し腹腔鏡下再噴門形成術を施行した1例

    加藤 伸史, 佐藤 千晃, 邑並 祐人, 角掛 純一, 廣瀬 亘, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　632-632　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  138. 難治性胃食道逆流症・食道裂孔ヘルニアに対する外科治療 Up-side down stomachを呈する食道裂孔ヘルニアに対する手術成績

    佐藤 千晃, 邑並 祐人, 金淵 佐和, 小関 健, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　821-821　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  139. 安全な食道切除・再建のための工夫 安全なロボット支援食道切除のために

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 金淵 佐和, 邑並 祐人, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　1070-1070　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  140. 陽子線治療後のサルベージ食道切除5例の検討

    邑並 祐人, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 金淵 佐和, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　2603-2603　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  141. ロボットの特性を活かした右上縦隔リンパ節郭清の工夫とその成績

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　28　(7)　2648-2648　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  142. 【進行消化器癌に対するconversion surgeryのすべて】肝胆膵 膵癌に対するconversion surgery

    前田 晋平, 水間 正道, 石田 晶玄, 三浦 孝之, 中川 圭, 海野 倫明

    外科　85　(13)　1435-1440　2023/12

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  143. 減量・代謝改善手術を安全かつ有効に行うためのちょっとした工夫 減量代謝改善手術 教室の工夫

    田中 直樹, 井本 博文, 土屋 尭裕, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　410-410　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  144. どこへいく?どうなる?複雑性腹壁瘢痕ヘルニア-ロボット支援手術vs腹腔鏡下手術vs開腹手術- 横切開創に合併した腹壁瘢痕ヘルニアの治療戦略

    山村 明寛, 西條 文人, 田中 直樹, 井本 博文, 土屋 堯裕, 川名 友美, 佐々木 啓迪, 岡本 浩二, 添田 敏寛, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　414-414　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  145. 減量・代謝改善手術後の合併症と修正手術 当院における減量・代謝改善手術後のRevision surgeryの現状と課題

    井本 博文, 田中 直樹, 土屋 尭裕, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　28　(7)　2249-2249　2023/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  146. 【進行消化器癌に対するconversion surgeryのすべて】肝胆膵 膵癌に対するconversion surgery

    前田 晋平, 水間 正道, 石田 晶玄, 三浦 孝之, 中川 圭, 海野 倫明

    外科　85　(13)　1435-1440　2023/12

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  147. Feasibility of Surveillance for Mucinous Cystic Neoplasm of the Pancreas: A Multi-Institutional Retrospective Study of 328 Patients by the Japanese Pancreatic Society. International-journal

    Yuto Hozaka, Takao Ohtsuka, Masafumi Nakamura, Susumu Hijioka, Michiaki Unno, Yasuhiro Shimizu, Minoru Tanabe, Yuichi Nagakawa, Etsuro Hatano, Manabu Kawai, Tsuyoshi Sano, Shinsuke Koshita, Akio Katanuma, Emiri Kita, Keiji Hanada, Yousuke Nakai, Takeshi Aoki, Masahiro Serikawa, Kojun Okamoto, Yoshifumi Takeyama

    Pancreas　2023/11/06

    DOI： 10.1097/MPA.0000000000002254 　

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    OBJECTIVE: We aimed to elucidate the feasibility of surveillance of patients with mucinous cystic neoplasm (MCN). METHODS: We performed a retrospective, multi-institutional study of 328 patients who underwent surgery for MCN at 18 Japanese institutions. Patients with MCN were divided into an immediate surgery group and a surveillance group, which underwent surgery after surveillance. RESULTS: The median surveillance period until surgery in the surveillance group was 27 months (range, 7-165 months). Compared with the immediate surgery group, the surveillance group showed smaller tumor diameter (46 vs 50 mm, P = 0.01), more frequent laparoscopic approach (58% vs 37%, P < 0.01), and less frequent malignancy (7% vs 15%, P = 0.03). The new appearance of mural nodules and elevation of serum tumor markers were associated with malignancy in the surveillance group. Two patients in the surveillance group experienced postoperative recurrence, although there was no significant difference in recurrence or disease-free survival between the two groups. In the surveillance group, the 1-, 5-, and 10-year cumulative incidence rates of malignant MCN were 0.8%, 5.6%, and 36.5%, respectively. CONCLUSION: As the risk of progression to malignant MCNs increases over the long term, MCNs should be resected rather than subjected to unnecessary surveillance.

  148. 膵退形成癌に対する術前治療

    水間 正道, 國米 崇, 柏木 良介, 日下 彬子, 青木 修一, 伊関 雅裕, 井上 亨悦, 堂地 大輔, 中山 瞬, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 粂 潔, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　56　(Suppl.2)　379-379　2023/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  149. 膵頭十二指腸切除後創し開・腸管皮膚瘻に対して長期間保存的加療を行った後に外科的閉鎖術を施行した一例

    伊関 雅裕, 中川 圭, 水間 正道, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 鈴木 綾乃, 黒沢 是之, 今井 啓道, 梅津 道久, 赤松 大二朗, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　20　(3)　448-448　2023/11

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  150. 膵頭十二指腸切除後創し開・腸管皮膚瘻に対して長期間保存的加療を行った後に外科的閉鎖術を施行した一例

    伊関 雅裕, 中川 圭, 水間 正道, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 鈴木 綾乃, 黒沢 是之, 今井 啓道, 梅津 道久, 赤松 大二朗, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　20　(3)　448-448　2023/11

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  151. A case of percutaneous transhepatic portal vein stenting without using iodinated contrast media for post pancreatectomy portal vein obstruction. International-journal

    Hinano Anaba, Sota Oguro, Hideki Ota, Satoru Yanagaki, Tomomi Sato, Kei Nakagawa, Michiaki Unno, Kei Takase

    BJR case reports　9　(6)　20220116-20220116　2023/11

    DOI： 10.1259/bjrcr.20220116 　

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    Postoperative portal vein obstruction could occur as a complication of portal vein reconstruction during hepatic lobectomy or pancreaticoduodenectomy. We report a case of patient with postoperative portal vein obstruction treated with percutaneous transhepatic portal vein stenting without using iodinated contrast media owing to a history of severe allergic reactions. Under ultrasound guidance, carbon dioxide angiography, and appropriate device selection, successful stenting was achieved without serious adverse events. After the operation, portal vein blood flow and clinical symptoms improved, enabling adjuvant chemotherapy. To the best of our knowledge, this is the first case report wherein percutaneous transhepatic portal vein stenting was successfully performed in a patient with an iodine allergy.

  152. CA19-9 With Two-stage Resection Is Useful for Conversion Surgery in PDAC With Synchronous Oligometastases. International-journal

    Koetsu Inoue, Masamichi Mizuma, Fuyuhiko Motoi, Takashi Kokumai, Hideaki Sato, Akiko Kusaka, Shuichi Aoki, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    Anticancer research　43　(11)　5223-5234　2023/11

    DOI： 10.21873/anticanres.16724 　

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    BACKGROUND/AIM: Pancreatic adenocarcinoma (PDAC) with synchronous oligometastases may indicate a surgical benefit after chemotherapy. We investigated whether primary and metastatic resection of PDAC with oligometastases can improve the survival and then explored prognostic factors to identify indications for conversion surgery. PATIENTS AND METHODS: We reviewed 425 patients with PDAC who underwent pancreatic resection from 2005 to 2019. Clinical characteristics and outcomes were analyzed. Two-stage resection was defined as preceding metastasectomy and subsequent primary resection after chemotherapy. RESULTS: Fifteen patients (3.5%) had synchronous oligometastases. We evaluated the overall survival of the patients with oligometastases and those without metastases. The survival curves almost completely overlapped (median survival time: 35.9 vs. 32.1 months). The univariate Cox regression analysis revealed a normal level of preoperative CA19-9 (p=0.075), two-stage resection (p=0.072), and R0 resection (p=0.064) were likely promising prognostic factors. The combination of a normal level of preoperative CA19-9 with two-stage resection was a significant prognostic factor (p=0.038). In addition, patients with a normal preoperative CA19-9 level and two-stage resection had better survival (46.1 vs. 28.1 months, p=0.026). CONCLUSION: The combination of normal preoperative CA19-9 with two-stage resection can be a useful way to identify patients with PDAC and oligometastases for surgical indication.

  153. Prognostic impact of postoperative infection after resection of biliary malignancy: A multicenter retrospective cohort study. International-journal

    Masahiro Iseki, Masamichi Mizuma, Michiaki Unno, Hiroshi Maruyama, Shinji Akagi, Mitsugi Shimoda, Kenichiro Uemura, Toru Inoue, Hisanori Shiomi, Manabu Watanabe, Minako Kobayashi, Akihisa Matsuda, Yusuke Mizuuchi, Taku Aoki, Hiroji Shinkawa, Risa Takahata, Kenta Makino, Hiroki Arai, Yasuyuki Yokoyama, Shigeru Takeda, Yoshihisa Yaguchi, Yuko Kitagawa

    Surgery　174　(5)　1145-1152　2023/11

    DOI： 10.1016/j.surg.2023.05.019 　

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    BACKGROUND: The aim of this study was to investigate the prognostic impact of postoperative infections in patients who underwent resection for biliary malignancy, including intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, distal cholangiocarcinoma, gallbladder carcinoma, and carcinoma of the ampulla of Vater. METHODS: This study was conducted in an 11-center retrospective cohort study. Patients with biliary tract cancer who underwent curative resection between April 2013 and March 2015 at 11 institutions in Japan were enrolled. We analyzed the prevalence of postoperative infection, infection-related factors, and prognostic factors. RESULTS: Of the total 290 cases, 33 were intrahepatic cholangiocarcinoma, 60 were perihilar cholangiocarcinoma, 120 were distal cholangiocarcinoma, 55 were gallbladder carcinoma, and 22 were carcinoma of the ampulla of Vater. Postoperative infectious complications, including remote infection, were observed in 146 patients (50.3%), and Clavien-Dindo ≥III in 115 patients (39.7%). Postoperative infections occurred more commonly in the patients who received pancreaticoduodenectomy and bile duct resection. Patients with infectious complications had a significantly poorer prognosis than those without (median overall survival 38 months vs 62 months, P = .046). In a diagnosis-specific analysis, although there was no correlation between infectious complications and overall survival in intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and carcinoma of the ampulla of Vater, infectious complications were a significantly poor prognostic factor in gallbladder carcinoma (P = .031). CONCLUSION: Postoperative infection after surgery for biliary tract cancer commonly occurred, especially in patients who underwent pancreaticoduodenectomy and bile duct resection. Postoperative infection is relatively associated with the prognosis of patients with biliary malignancy, especially gallbladder carcinoma.

  154. Living-Donor Liver Transplantation for Erythropoietic Protoporphyria: A Case Report and Literature Review.

    Hiroyuki Ogasawara, Kazuaki Tokodai, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Yoshihiro Shono, Mineto Ohta, Yuki Ishikawa, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　261　(2)　117-122　2023/10/07

    DOI： 10.1620/tjem.2023.J061 　

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    Erythropoietic protoporphyria (EPP) is a very rare disease with an estimated prevalence of 1 in 200,000 individuals. Decreased ferrochelatase activity causes the accumulation of protoporphyrin in the body, and light exposure results in the generation of active oxygen, causing photosensitivity. Liver damage has the greatest influence on the prognosis, and liver transplantation is the only treatment option for patients with decompensated liver cirrhosis. We report a case of living-donor liver transplantation for decompensated liver cirrhosis associated with EPP. The patient was a 52-year-old male who led a normal life except for mild photosensitivity. When the patient was 37-year-old, hepatic dysfunction was noticed. At 48-year-old, high erythrocyte protoporphyrin levels, skin biopsy, and genetic tests resulted in a diagnosis of EPP. The patient underwent living- donor liver transplantation because of decompensated liver cirrhosis. In the operating room and intensive care unit, a special light-shielding film was applied to all light sources to block light with harmful wavelengths during treatment. Due to the need for special measures, a lecture on patients with EPP was given before surgery to deepen understanding among all medical professionals involved in the treatment. As a result, no adverse events occurred during the perioperative period, and the patient was discharged on the 46th post-operative day. Currently, the transplanted liver is functioning extremely well, and the patient is alive 3 years post-transplant. Herein, we describe a case of living donor liver transplantation for EPP with a brief literature review.

  155. 直腸悪性腫瘍に対する拡大手術後の自家組織を用いた会陰再建術

    大沼 忍, 唐澤 秀明, 初沢 悠人, 小野 智之, 小林 実, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　48　(5)　572-572　2023/10

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  156. 食道癌放射線化学療法後の局所遺残再発に対する光線力学療法(PDT)の有効性と安全性

    邑並 祐人, 佐藤 千晃, 谷山 裕亮, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    Gastroenterological Endoscopy　65　(Suppl.2)　1965-1965　2023/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  157. 胸腔鏡下に切除した瘻孔形成を伴う食道嚢胞の一例

    宮田 惟, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本胸部外科学会定期学術集会　76回　ECPA1-4　2023/10

    Publisher: (一社)日本胸部外科学会

  158. 未分化型早期胃癌におけるPoorly cohesive carcinomaの臨床病理学的特徴および予後の検討

    山村 明寛, 田中 直樹, 井本 博文, 土屋 堯裕, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会雑誌　120　(臨増大会)　A762-A762　2023/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  159. 食道癌放射線化学療法後の局所遺残再発に対する光線力学療法(PDT)の有効性と安全性

    邑並 祐人, 佐藤 千晃, 谷山 裕亮, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    Gastroenterological Endoscopy　65　(Suppl.2)　1965-1965　2023/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  160. persistent type2エンドリークに対する対策 瘤径拡大を基準としたType 2エンドリーク症例への介入は必要か

    芹澤 玄, 赤松 大二朗, 梅津 道久, 鈴木 峻也, 清水 港太, 木村 俊作, 村上 皓彦, 海野 倫明, 亀井 尚

    脈管学　63　(Suppl.)　S111-S112　2023/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  161. Gene rearrangement and expression of PRKACA and PRKACB governs morpho-biology of pancreatobiliary oncocytic neoplasms

    Taito Itoh, Yuko Omori, Mitsuru Seino, Katsuya Hirose, Fumiko Date, Yusuke Ono, Yusuke Mizukami, Shuichi Aoki, Masaharu Ishida, Masamichi Mizuma, Takanori Morikawa, Ryota Higuchi, Goro Honda, Yasunobu Okamura, Kengo Kinoshita, Michiaki Unno, Toru Furukawa

    Modern Pathology　100358-100358　2023/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.modpat.2023.100358 　

    ISSN： 0893-3952

  162. Tumor-to-Tumor Metastasis of Medullary Thyroid Carcinoma to Paraganglioma in a Multiple Endocrine Neoplasia Type 2B Patient: A Case Report and Literature Review.

    Naruhito Takido, Ryusuke Saito, Kaoru Okada, Norifumi Kanai, Yoshihiro Shono, Hiroaki Mitsugashira, Muneyuki Matsumura, Kengo Sasaki, Koji Miyazawa, Atsushi Fujio, Kazuaki Tokodai, Keigo Murakami, Hironobu Sasano, Michiaki Unno, Takanori Ishida, Takashi Kamei

    The Tohoku journal of experimental medicine　261　(1)　75-81　2023/09/20

    DOI： 10.1620/tjem.2023.J058 　

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    Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize to other tumors. Herein, we report an extremely rare case of tumor-to-tumor metastasis of medullary thyroid carcinoma to a paraganglioma in a patient with multiple endocrine neoplasia type 2B. Based on genetic examination, a 36-year-old woman was diagnosed with multiple endocrine neoplasia type 2B when she was 24 years old. She had a history of total thyroidectomy for medullary thyroid carcinoma and bilateral adrenalectomy for pheochromocytomas, which were performed when she was 15 years and 29 years old, respectively. Follow-up computed tomography demonstrated a retroperitoneal tumor of 30 mm in diameter beside the left kidney and a liver tumor of 16 mm in diameter located in segment 6. The retroperitoneal and liver tumors were surgically resected and examined by a pathologist. Histological examination revealed the classic Zellballen pattern in the retroperitoneal tumor, rendering the diagnosis of a paraganglioma recurrence. Inside the tumor, a white nodule positive for carcinoembryonic antigen, weakly positive for calcitonin, and negative for tyrosine hydroxylase, was identified and diagnosed as a metastatic medullary thyroid carcinoma with high malignant potential. The liver lesion was diagnosed as a metastasis of the medullary thyroid carcinoma. This is the first report of tumor-to-tumor metastasis of medullary thyroid carcinoma to paraganglioma in a patient with multiple endocrine neoplasia type 2B twenty years after total thyroidectomy.

  163. Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment. International-journal

    Ryosuke Kashiwagi, Ryo Funayama, Shuichi Aoki, Aya Matsui, Sebastian Klein, Yukihiro Sato, Tsubasa Suzuki, Keigo Murakami, Koetsu Inoue, Masahiro Iseki, Kunihiro Masuda, Masamichi Mizuma, Hisamichi Naito, Dan G Duda, Michiaki Unno, Keiko Nakayama

    Cancer science　2023/09/08

    DOI： 10.1111/cas.15952 　

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    Expression of the gene for collagen XVII (COL17A1) in tumor tissue is positively or negatively associated with patient survival depending on cancer type. High COL17A1 expression is thus a favorable prognostic marker for breast cancer but unfavorable for pancreatic cancer. This study explored the effects of COL17A1 expression on pancreatic tumor growth and their underlying mechanisms. Analysis of published single-cell RNA-sequencing data for human pancreatic cancer tissue revealed that COL17A1 was expressed predominantly in cancer cells rather than surrounding stromal cells. Forced expression of COL17A1 did not substantially affect the proliferation rate of the mouse pancreatic cancer cell lines KPC and AK4.4 in vitro. However, in mouse homograft tumor models in which KPC or AK4.4 cells were injected into syngeneic C57BL/6 or FVB mice, respectively, COL17A1 expression promoted or suppressed tumor growth, respectively, suggesting that the effect of COL17A1 on tumor growth was influenced by the tumor microenvironment. RNA-sequencing analysis of tumor tissue revealed effects of COL17A1 on gene expression profiles (including the expression of genes related to cell proliferation, the immune response, Wnt signaling, and Hippo signaling) that differed between C57BL/6-KPC and FVB-AK4.4 tumors. Our data thus suggest that COL17A1 promotes or suppresses cancer progression in a manner dependent on the interaction of tumor cells with the tumor microenvironment.

  164. Insights from managing clinical issues in distal pancreatectomy with en bloc coeliac axis resection: experiences from 626 patients. International-journal

    Toru Nakamura, Ken-Ichi Okada, Masayuki Ohtsuka, Ryota Higuchi, Hidenori Takahashi, Kazuyuki Nagai, Michiaki Unno, Yoshiaki Murakami, Atsushi Oba, Moriaki Tomikawa, Atsushi Kato, Akihiko Horiguchi, Masafumi Nakamura, Shintaro Yagi, Sohei Satoi, Itaru Endo, Ryosuke Amano, Ippei Matsumoto, Yoichi M Ito, Takukazu Nagakawa, Satoshi Hirano

    The British journal of surgery　110　(10)　1387-1394　2023/09/06

    DOI： 10.1093/bjs/znad212 　

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    BACKGROUND: Distal pancreatectomy with en bloc coeliac axis resection (DP-CAR) for pancreatic body cancer has been reported increasingly. However, its large-scale outcomes remain undocumented. This study aimed to evaluate DP-CAR volume and mortality, preoperative arterial embolization for ischaemic gastropathy, the oncological benefit for resectable tumours close to the bifurcation of the splenic artery and coeliac artery using propensity score matching, and prognostic factors in DP-CAR. METHODS: In a multi-institutional analysis, 626 DP-CARs were analysed retrospectively and compared with 1325 distal pancreatectomies undertaken in the same interval. RESULTS: Ninety-day mortality was observed in 7 of 21 high-volume centres (1 or more DP-CARs per year) and 1 of 41 low-volume centres (OR 20.00, 95 per cent c.i. 2.26 to 177.26). The incidence of ischaemic gastropathy was 19.2 per cent in the embolization group and 7.9 per cent in the no-embolization group (OR 2.77, 1.48 to 5.19). Propensity score matching analysis showed that median overall survival was 33.5 (95 per cent c.i. 27.4 to 42.0) months in the DP-CAR and 37.9 (32.8 to 53.3) months in the DP group. Multivariable analysis identified age at least 67 years (HR 1.40, 95 per cent c.i. 1.12 to 1.75), preoperative tumour size 30 mm or more (HR 1.42, 1.12 to 1.80), and preoperative carbohydrate antigen 19-9 level over 37 units/ml (HR 1.43, 1.11 to 1.83) as adverse prognostic factors. CONCLUSION: DP-CAR can be performed safely in centres for general pancreatic surgery regardless of DP-CAR volume, and preoperative embolization may not be required. This procedure has no oncological advantage for resectable tumour close to the bifurcation of the splenic artery, and should be performed after appropriate patient selection.

  165. Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer. International-journal

    Jingyu Xun, Hideo Ohtsuka, Katsuya Hirose, Daisuke Douchi, Shun Nakayama, Masaharu Ishida, Takayuki Miura, Kyohei Ariake, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno

    BMC cancer　23　(1)　835-835　2023/09/06

    DOI： 10.1186/s12885-023-11294-3 　

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    BACKGROUND: Loss of expression of the gene ataxia-telangiectasia mutated (ATM), occurring in patients with multiple primary malignancies, including pancreatic cancer, is associated with poor prognosis. In this study, we investigated the detailed molecular mechanism through which ATM expression affects the prognosis of patients with pancreatic cancer. METHODS: The levels of expression of ATM and phosphorylated ATM in patients with pancreatic cancer who had undergone surgical resection were analyzed using immunohistochemistry staining. RNA sequencing was performed on ATM-knockdown pancreatic-cancer cells to elucidate the mechanism underlying the invlovement of ATM in pancreatic cancer. RESULTS: Immunohistochemical analysis showed that 15.3% and 27.8% of clinical samples had low levels of ATM and phosphorylated ATM, respectively. Low expression of phosphorylated ATM substantially reduced overall and disease-free survival in patients with pancreatic cancer. In the pancreatic cancer cell lines with ATM low expression, resistance to gemcitabine was demonstrated. The RNA sequence demonstrated that ATM knockdown induced the expression of MET and NTN1. In ATM knockdown cells, it was also revealed that the protein expression levels of HIF-1α and antiapoptotic BCL-2/BAD were upregulated. CONCLUSIONS: These findings demonstrate that loss of ATM expression increases tumor development, suppresses apoptosis, and reduces gemcitabine sensitivity. Additionally, loss of phosphorylated ATM is associated with a poor prognosis in patients with pancreatic cancer. Thus, phosphorylated ATM could be a possible target for pancreatic cancer treatment as well as a molecular marker to track patient prognosis.

  166. Evidence-based clinical practice guidelines for cholelithiasis 2021.

    Naotaka Fujita, Ichiro Yasuda, Itaru Endo, Hiroyuki Isayama, Takuji Iwashita, Toshiharu Ueki, Kenichiro Uemura, Akiko Umezawa, Akio Katanuma, Yu Katayose, Yutaka Suzuki, Junichi Shoda, Toshio Tsuyuguchi, Toshifumi Wakai, Kazuo Inui, Michiaki Unno, Yoshifumi Takeyama, Takao Itoi, Kazuhiko Koike, Satoshi Mochida

    Journal of gastroenterology　58　(9)　801-833　2023/09

    DOI： 10.1007/s00535-023-02014-6 　

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    The Japanese Society of Gastroenterology first published evidence-based clinical practice guidelines for cholelithiasis in 2010, followed by a revision in 2016. Currently, the revised third edition was published to reflect recent evidence on the diagnosis, treatment, and prognosis of cholelithiasis conforming to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Following this revision, the present English version of the guidelines was updated and published herein. The clinical questions (CQ) in the previous version were reviewed and rearranged into three newly divided categories: background questions (BQ) dealing with basic background knowledge, CQ, and future research questions (FRQ), which refer to issues that require further accumulation of evidence. Finally, 52 questions (29 BQs, 19 CQs, and 4 FRQs) were adopted to cover the epidemiology, pathogenesis, diagnosis, treatment, complications, and prognosis. Based on a literature search using MEDLINE, Cochrane Library, and Igaku Chuo Zasshi databases for the period between 1983 and August 2019, along with a manual search of new information reported over the past 5 years, the level of evidence was evaluated for each CQ. The strengths of recommendations were determined using the Delphi method by the committee members considering the body of evidence, including benefits and harms, patient preference, and cost-benefit balance. A comprehensive flowchart was prepared for the diagnosis and treatment of gallbladder stones, common bile duct stones, and intrahepatic stones, respectively. The current revised guidelines are expected to be of great assistance to gastroenterologists and general physicians in making decisions on contemporary clinical management for cholelithiasis patients.

  167. 膵・胆管合流異常の胆嚢内に発生した胆嚢内乳頭状腫瘍(Intracystic papillary neoplasm;ICPN)症例の検討

    國米 崇, 三浦 孝之, 大塚 英郎, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 古川 徹, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　46　22-22　2023/09

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  168. 不織布構造ゼラチン基材を用いた肝表面膵島移植法の検討

    遠藤 有希子, 稲垣 明子, 猪村 武弘, 鈴木 翔輝, 片野 匠, 戸子台 和哲, 亀井 尚, 海野 倫明, 田畑 泰彦, 後藤 昌史

    移植　58　(総会臨時)　292-292　2023/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  169. 10年以上の小児肝移植長期成績の課題 当院における小児肝移植の長期成績の課題

    佐々木 健吾, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 松村 宗幸, 三頭 啓明, 齊藤 竜介, 亀井 尚, 海野 倫明

    移植　58　(総会臨時)　173-173　2023/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  170. 膵臓移植"HOW I DO IT" 東北大学における膵臓移植手術手技 わたしのこだわり

    松村 宗幸, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 三頭 啓明, 齋藤 竜助, 海野 倫明, 亀井 尚

    移植　58　(総会臨時)　200-200　2023/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  171. 肛門管癌の治療 ストーマフリーの観点からみた肛門管扁平上皮癌に対するCRTの治療成績/大腸癌研究会プロジェクト研究「肛門管癌の病態解明とStagingに関する研究」副次研究

    神山 篤史, 大沼 忍, 海野 倫明, 味岡 洋一, 杉原 健一, 山田 一隆

    日本大腸肛門病学会雑誌　76　(9)　A94-A94　2023/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  172. Features of T1 pancreatic cancer and validation of the eighth edition AJCC staging system definition using a Korean-Japanese joint cohort and the SEER database.

    Wooil Kwon, Jin Seok Heo, In Woong Han, Chang Moo Kang, Ho Kyoung Hwang, Song Cheol Kim, Sang-Jae Park, Yoo-Seok Yoon, Yong Hoon Kim, Chang-Sup Lim, Seung Yeoun Lee, Taesung Park, Hideki Takami, Nobuyuki Watanabe, Yasuhiro Shimizu, Masataka Okuno, Hiroki Yamaue, Manabu Kawai, Hirono Seiko, Yuichi Nagakawa, Hiroaki Osakabe, Teiichi Sugiura, Hirochika Toyama, Masayuki Ohtsuka, Michiaki Unno, Itaru Endo, Minoru Kitago, Jin-Young Jang

    Journal of hepato-biliary-pancreatic sciences　30　(9)　1129-1140　2023/09

    DOI： 10.1002/jhbp.1316 　

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    BACKGROUND/PURPOSE: Little is known about the features of T1 pancreatic ductal adenocarcinoma (PDAC) and its definition in the eighth edition of the American Joint Committee on Cancer (AJCC) staging system needs validation. The aims were to analyze the clinicopathologic features of T1 PDAC and investigate the validity of its definition. METHOD: Data from 1506 patients with confirmed T1 PDAC between 2000 and 2019 were collected and analyzed. The results were validated using 3092 T1 PDAC patients from the Surveillance, Epidemiology, and End Results (SEER) database. RESULTS: The median survival duration of patients was 50 months, and the 5-year survival rate was 45.1%. R0 resection was unachievable in 10.0% of patients, the nodal metastasis rate was 40.0%, and recurrence occurred in 55.2%. The current T1 subcategorization was not feasible for PDAC, tumors with extrapancreatic extension (72.8%) had worse outcomes than those without extrapancreatic extension (median survival 107 vs. 39 months, p < .001). Extrapancreatic extension was an independent prognostic factor whereas the current T1 subcategorization was not. The results of this study were reproducible with data from the SEER database. CONCLUSION: Despite its small size, T1 PDAC displayed aggressive behavior warranting active local and systemic treatment. The subcategorization by the eighth edition of the AJCC staging system was not adequate for PDAC, and better subcategorization methods need to be explored. In addition, the role of extrapancreatic extension in the staging system should be reconsidered.

  173. 【胆道癌と膵癌のリスクファクター】胆嚢結石症は胆嚢癌のリスクファクターか

    大塚 英郎, 三浦 孝之, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    胆と膵　44　(9)　853-859　2023/09

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  174. Impact of antithrombotic therapy on postpancreatectomy hemorrhage in 7116 patients: A project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.

    Kota Nakamura, Minako Nagai, Ippei Matsumoto, Sohei Satoi, Fuyuhiko Motoi, Manabu Kawai, Yasuo Hosouchi, Ryota Higuchi, Shugo Mizuno, Takao Ohtsuka, Keiichi Akahoshi, Kenichi Hakamada, Michiaki Unno, Hiroki Yamaue, Masafumi Nakamura, Itaru Endo, Masayuki Sho

    Journal of hepato-biliary-pancreatic sciences　2023/09/01

    DOI： 10.1002/jhbp.1349 　

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    BACKGROUND: We previously reported an association between antithrombotic therapy and an increased risk of postpancreatectomy hemorrhage (PPH). To validate our findings, we conducted a large-scale multicenter retrospective study from 63 high-volume centers in Japan. METHODS: Between 2015 and 2018, 7116 patients who underwent pancreatectomy were enrolled. The antithrombotic group consisted of 920 patients (12.9%) who received preoperative antithrombotic agents including aspirin, clopidogrel, ticlopidine, prasugrel, warfarin, and direct oral anticoagulants. RESULTS: PPH occurred in 235 (3.3%) of the patients. The incidence of PPH and mortality were significantly higher in the antithrombotic group than in the control group (5.7 vs. 3.0% and 2.2 vs. 0.9%, respectively; both p < .001). In multivariate analysis, a history of antithrombotic use was an independent risk factor for grade C PPH (p = .036). In the antithrombotic group, PPH tended to be delayed in the patients with restarting antithrombotic therapy. Notably, the occurrence of delayed PPH after restarting antithrombotic therapy was observed only when antithrombotic therapy was restarted within 10 days after pancreatectomy. CONCLUSIONS: This multicenter study demonstrated that a history of antithrombotic use was a significant risk factor for PPH and mortality. In particular, the resumption of antithrombotic therapy in the early postoperative period should be done with caution.

  175. 切除不能胆管癌に対するconversion surgeryの現状と課題

    青木 修一, 中川 圭, 海野 倫明, 伊関 雅裕, 國米 崇, 佐藤 英昭, 日下 彬子, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道

    胆道　37　(3)　598-598　2023/08

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  176. 肝門部領域胆管癌の術前診断における各検査の正診率

    伊関 雅裕, 中川 圭, 海野 倫明, 青木 修一, 國米 崇, 佐藤 英昭, 日下 彬子, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 三浦 晋, 正宗 淳

    胆道　37　(3)　447-447　2023/08

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  177. A gelatin hydrogel nonwoven fabric improves outcomes of subcutaneous islet transplantation. International-journal

    Norifumi Kanai, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Hiroaki Mitsugashira, Ryusuke Saito, Shigehito Miyagi, Kimiko Watanabe, Takashi Kamei, Michiaki Unno, Yasuhiko Tabata, Masafumi Goto

    Scientific reports　13　(1)　11968-11968　2023/07/24

    DOI： 10.1038/s41598-023-39212-4 　

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    Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously reported that a recombinant peptide (RCP) enhances subcutaneous islet engraftment. However, it is impractical for clinical use because RCP must be removed when transplanting islets. We herein investigated whether a novel bioabsorbable gelatin hydrogel nonwoven fabric (GHNF) could improve subcutaneous islet engraftment. A silicon spacer with or without GHNF was implanted into the subcutaneous space of diabetic mice. Syngeneic islets were transplanted into the pretreated space or intraportally (Ipo group). Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, CT angiography and gene expression were evaluated. The cure rate and glucose tolerance of the GHNF group were significantly better than in the control and Ipo groups (p < 0.01, p < 0.05, respectively). In the GHNF group, a limited increase of vWF-positive vessels was detected in the islet capsule, whereas laminin (p < 0.05), collagen III and IV were considerably enhanced. TaqMan arrays revealed a significant upregulation of 19 target genes (including insulin-like growth factor-2) in the pretreated space. GHNF markedly improved the subcutaneous islet transplantation outcomes, likely due to ECM compensation and protection of islet function by various growth factors, rather than enhanced neovascularization.

  178. Clinical impact of multimodal treatment including chemoradiotherapy, conversion surgery and postoperative chemotherapy for borderline resectable and unresectable locally advanced pancreatic cancer without disease progression after gemcitabine plus nab-paclitaxel. International-journal

    Rei Umezawa, Masamichi Mizuma, Kei Nakagawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Michiaki Unno, Keiichi Jingu

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　2023/07/04

    DOI： 10.1016/j.pan.2023.07.002 　

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    BACKGROUND: The purpose of this study was to investigate treatment outcomes of chemoradiotherapy (CRT) using S-1 with or without conversion surgery after gemcitabine plus nab-paclitaxel (GnP) for borderline resectable (BR) and unresectable locally advanced (UR-LA) pancreatic cancer. METHODS: From 2016 to 2020, patients without disease progression after GnP for BR or UR-LA pancreatic cancer underwent CRT with S-1. If distant metastasis was not detected after CRT, conversion surgery and oral administration of S-1 as postoperative adjuvant chemotherapy for at least 6 months was performed. RESULTS: Forty patients were included in the present study. The median number of cycles of GnP was 6. Surgery was performed after CRT in 25 patients. The median progression-free survival (PFS) and overall survival (OS) periods from the start of radiotherapy were 24.6 and 27.4 months, respectively. The OS periods from the start of radiotherapy in patients who underwent conversion surgery and those who did not undergo conversion surgery were 41.3 and 16.8 months, respectively. The PFS periods from the start of radiotherapy in patients who underwent surgery and those who did not undergo surgery were 28.3 and 8.6 months, respectively. Patients who were able to receive S-1 after conversion surgery for more than 6 months had better OS than those who were not (p = 0.039), although there was no significant difference of PFS (p = 0.365). CONCLUSIONS: In BR/UR-LA pancreatic cancer without disease progression after GnP, multimodal treatment including CRT, conversion surgery and the scheduled postoperative chemotherapy may be effective.

  179. 当施設におけるロボット支援下膵頭十二指腸切除術の導入

    石田 晶玄, 三浦 孝之, 佐藤 英昭, 青木 修一, 伊関 雅裕, 前田 晋平, 水間 正道, 大塚 英郎, 中川 圭, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　215回・170回　190-190　2023/07

    Publisher: 日本消化器病学会-東北支部

  180. 肝移植後の消化器癌スクリーニングの検討

    藤尾 淳, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 山名 浩樹, 三頭 啓明, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　RS1-2　2023/07

    Publisher: (一社)日本消化器外科学会

  181. 東北大学Cadaverトレーニングの現状と脳死ドナー臓器摘出手術における成果

    戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 大和田 祐二, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　RS5-2　2023/07

    Publisher: (一社)日本消化器外科学会

  182. 生体肝移植後胆管狭窄に対する治療アプローチ

    佐々木 健吾, 戸子台 和哲, 藤尾 淳, 柏館 俊明, 宮澤 恒持, 松村 宗幸, 山名 浩樹, 三頭 啓明, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　RS15-2　2023/07

    Publisher: (一社)日本消化器外科学会

  183. 当科における腹腔鏡下再肝切除の適応と工夫について

    岡田 薫, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 森川 孝則, 戸子台 和哲, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P115-5　2023/07

    Publisher: (一社)日本消化器外科学会

  184. 大腸癌肝転移症例における腹腔鏡下肝切除の長期および短期成績の検討

    山名 浩樹, 藤尾 淳, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 三頭 啓明, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　P203-2　2023/07

    Publisher: (一社)日本消化器外科学会

  185. 肝移植レシピエントにおけるサルコペニアの影響

    三頭 啓明, 藤尾 淳, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 山名 浩樹, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P270-4　2023/07

    Publisher: (一社)日本消化器外科学会

  186. 高齢化および免疫統御療法時代の潰瘍性大腸炎の周術期管理の問題点

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　O13-5　2023/07

    Publisher: (一社)日本消化器外科学会

  187. クローン病の短腸症候群(腸管不全)におけるサルコペニアの実態および栄養管理への取り組み

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　O22-3　2023/07

    Publisher: (一社)日本消化器外科学会

  188. 在宅中心静脈栄養におけるCVカテーテル関連感染症と季節・気候との関係性の検討

    小林 実, 渡辺 和宏, 西條 文人, 小野 智之, 梶原 大輝, 唐澤 秀明, 神山 篤史, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　P045-8　2023/07

    Publisher: (一社)日本消化器外科学会

  189. 悪性腸閉塞に対する緩和医療としての積極的外科療法の有用性

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　P135-7　2023/07

    Publisher: (一社)日本消化器外科学会

  190. 75歳以上かつASA-PS3以上の根治切除可能大腸癌に対する短期治療成績

    唐澤 秀明, 小野 智之, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　P171-6　2023/07

    Publisher: (一社)日本消化器外科学会

  191. 人工肛門閉鎖部腹壁瘢痕ヘルニアの発生危険因子

    梶原 大輝, 小野 智之, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　P188-5　2023/07

    Publisher: (一社)日本消化器外科学会

  192. 機械学習による直腸癌術前化学放射線療法の効果予測

    小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　78回　P262-3　2023/07

    Publisher: (一社)日本消化器外科学会

  193. 【総論】ロボット支援手術時代の若手消化器外科医の教育 当科におけるロボット支援下食道切除術の治療成績と指導体制

    佐藤 千晃, 加藤 伸史, 小関 健, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　WS2-3　2023/07

    Publisher: (一社)日本消化器外科学会

  194. 【総論】大腸癌以外のoligometastasisに対する集学的治療の現状と課題 食道癌根治切除後のOligometastasis症例に対する治療戦略の検討

    石田 裕嵩, 谷山 裕亮, 加藤 伸史, 小澤 洋平, 岡本 宏史, 佐藤 千晃, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　WS5-1　2023/07

    Publisher: (一社)日本消化器外科学会

  195. 80歳以上の高齢者の食道癌根治手術およびリンパ節郭清省略に関する検討

    邑並 祐人, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　RS7-5　2023/07

    Publisher: (一社)日本消化器外科学会

  196. 胆膵消化管に発生した混合型神経内分泌腫瘍患者における腫瘍組織微小環境の検討

    角掛 純一, 藤島 史喜, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 海野 倫明, 笹野 公伸, 亀井 尚

    日本消化器外科学会総会　78回　P015-5　2023/07

    Publisher: (一社)日本消化器外科学会

  197. 高度進行食道胃接合部腺癌に対する導入化学療法後切除症例の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P061-4　2023/07

    Publisher: (一社)日本消化器外科学会

  198. 胸腔鏡下に切除した瘻孔形成を伴う食道嚢胞の一例

    宮田 惟, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P136-2　2023/07

    Publisher: (一社)日本消化器外科学会

  199. 食道癌手術症例におけるBIA法によるサルコペニアの特徴と周術期推移や手術成績に与える影響の検討

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P217-7　2023/07

    Publisher: (一社)日本消化器外科学会

  200. 食道癌に対する食道切除術後乳び胸の危険因子と治療法の検討

    土谷 祐馬, 小澤 洋平, 小関 健, 石田 裕嵩, 佐藤 千晃, 岡本 宏史, 谷山 裕亮, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　P206-7　2023/07

    Publisher: (一社)日本消化器外科学会

  201. 完全内臓逆位に生じた肝門部領域胆管癌に対して大量肝切除術を施行した一例

    平野 直大, 伊関 雅裕, 中川 圭, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 水間 正道, 大沼 忍, 亀井 尚, 松本 諒太郎, 三浦 晋, 粂 潔, 正宗 淳, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　215回・170回　165-165　2023/07

    Publisher: 日本消化器病学会-東北支部

  202. 膵癌におけるEUS-FNAと腹腔洗浄細胞診および予後との関連

    中山 瞬, 水間 正道, 國米 崇, 柏木 良介, 日下 彬子, 青木 修一, 井上 亨悦, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 粂 潔, 正宗 淳, 古川 徹, 海野 倫明

    膵臓　38　(3)　A411-A411　2023/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  203. 感染性大動脈-十二指腸瘻の診断にビスコクリアを用いた内視鏡観察が有用であった一例

    鈴木 直生, 齊藤 真弘, 宇野 要, 金 笑奕, 小池 智幸, 正宗 淳, 赤松 大二朗, 水間 正道, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　215回・170回　162-162　2023/07

    Publisher: 日本消化器病学会-東北支部

  204. 転移性膵癌に対する治療戦略 膵癌切除例における腹腔細胞診疑陽性の臨床的意義 膵癌取扱い規約検討委員会研究

    田中 晴祥, 平林 健一, 藤井 努, 大池 信之, 上野 誠, 水井 崇浩, 石田 晶玄, 江川 新一, 古川 徹, 永川 裕一, 糸井 隆夫, 北川 裕久, 眞杉 洋平, 谷 眞至, 福嶋 敬宜, 羽鳥 隆, 里井 壯平, 海野 倫明, 竹山 宜典, 膵癌取扱い規約検討委員会

    膵臓　38　(3)　A156-A156　2023/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  205. 【上部】超高齢者胃癌に対する手術適応と術式選択 85歳以上の超高齢者胃癌に対する術式選択と治療成績の検証

    田中 直樹, 山村 明寛, 井本 博文, 土屋 尭裕, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　WS13-4　2023/07

    Publisher: (一社)日本消化器外科学会

  206. 腹腔鏡下スリープ・バイパス術を安全に行うための体腔内吻合の工夫

    井本 博文, 田中 直樹, 土屋 尭裕, 山村 明寛, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　O18-1　2023/07

    Publisher: (一社)日本消化器外科学会

  207. 腹腔鏡下誘導前方切開法または膨潤TAPP法を用いた再発鼡径ヘルニア手術

    土屋 堯裕, 西條 文人, 田中 直樹, 山村 明寛, 井本 博文, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　P150-5　2023/07

    Publisher: (一社)日本消化器外科学会

  208. 【総論】ロボット支援手術時代の若手消化器外科医の教育 当科におけるロボット支援下食道切除術の治療成績と指導体制

    佐藤 千晃, 加藤 伸史, 小関 健, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　WS2-3　2023/07

    Publisher: (一社)日本消化器外科学会

  209. 【総論】大腸癌以外のoligometastasisに対する集学的治療の現状と課題 食道癌根治切除後のOligometastasis症例に対する治療戦略の検討

    石田 裕嵩, 谷山 裕亮, 加藤 伸史, 小澤 洋平, 岡本 宏史, 佐藤 千晃, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　WS5-1　2023/07

    Publisher: (一社)日本消化器外科学会

  210. 80歳以上の高齢者の食道癌根治手術およびリンパ節郭清省略に関する検討

    邑並 祐人, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　RS7-5　2023/07

    Publisher: (一社)日本消化器外科学会

  211. 胆膵消化管に発生した混合型神経内分泌腫瘍患者における腫瘍組織微小環境の検討

    角掛 純一, 藤島 史喜, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 海野 倫明, 笹野 公伸, 亀井 尚

    日本消化器外科学会総会　78回　P015-5　2023/07

    Publisher: (一社)日本消化器外科学会

  212. 高度進行食道胃接合部腺癌に対する導入化学療法後切除症例の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P061-4　2023/07

    Publisher: (一社)日本消化器外科学会

  213. 胸腔鏡下に切除した瘻孔形成を伴う食道嚢胞の一例

    宮田 惟, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P136-2　2023/07

    Publisher: (一社)日本消化器外科学会

  214. 食道癌に対する食道切除術後乳び胸の危険因子と治療法の検討

    土谷 祐馬, 小澤 洋平, 小関 健, 石田 裕嵩, 佐藤 千晃, 岡本 宏史, 谷山 裕亮, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　78回　P206-7　2023/07

    Publisher: (一社)日本消化器外科学会

  215. 食道癌手術症例におけるBIA法によるサルコペニアの特徴と周術期推移や手術成績に与える影響の検討

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　78回　P217-7　2023/07

    Publisher: (一社)日本消化器外科学会

  216. 膵臓疾患に対する周術期における栄養管理 膵癌術前化学療法が血清亜鉛値に与える影響

    伊関 雅裕, 水間 正道, 國米 崇, 柏木 良介, 日下 彬子, 青木 修一, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 海野 倫明

    膵臓　38　(3)　A278-A278　2023/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  217. 膵癌におけるEUS-FNAと腹腔洗浄細胞診および予後との関連

    中山 瞬, 水間 正道, 國米 崇, 柏木 良介, 日下 彬子, 青木 修一, 井上 亨悦, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 粂 潔, 正宗 淳, 古川 徹, 海野 倫明

    膵臓　38　(3)　A411-A411　2023/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  218. Standard versus delayed initiation of S-1 adjuvant chemotherapy after surgery for pancreatic cancer: a secondary analysis of a nationwide cohort by the Japan Pancreas Society.

    Yoshito Tomimaru, Hidetoshi Eguchi, Yoshimitsu Shimomura, Tetsuhisa Kitamura, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Shunsuke Onoe, Michiaki Unno, Daisuke Hashimoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Kenichiro Uemura, Yasutoshi Kimura, Sohei Satoi, Yoshifumi Takeyama

    Journal of gastroenterology　2023/06/17

    DOI： 10.1007/s00535-023-01988-7 　

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    BACKGROUND: Based on the Japan Adjuvant Study Group of Pancreatic Cancer-01 results, S-1 adjuvant chemotherapy has been the standard in resected pancreatic ductal adenocarcinoma (PDAC) patients in Japan and elsewhere, initiated within 10 weeks after surgery. To assess the clinical impact of this timing, we conducted a secondary analysis of a nationwide survey by the Japan Pancreas Society. METHODS: A total of 3361 patients were divided into two groups: 2681 (79.8%) initiating the therapy within 10 weeks after surgery (standard) and 680 (20.2%) after 10 weeks (delayed). We compared recurrence-free survival (RFS) and overall survival (OS) using the log-rank test and Cox proportional hazards model with conditional landmark analysis between the groups. Results were verified by adjustment with inverse-probability-of-treatment weighting (IPTW) analysis. RESULTS: The median timing of S-1 adjuvant chemotherapy initiation was 50 days (interquartile range: 38-66). In the standard group, 5-year RFS and OS rates were 32.3-48.7%, respectively, compared with 25.0-38.7% in the delayed group. Hazard ratios (HRs) and 95% confidence intervals were 0.84 (0.76-0.93) for RFS (p < 0.001) and 0.77 (0.69-0.87) for OS (p < 0.001). The IPTW analysis yielded 5-year RFS rates of 32.1% and 25.3% in the standard versus delayed group, respectively [HR = 0.86 (0.77-0.96), p < 0.001] and 5-year OS rates of 48.3% and 39.8%, respectively [HR = 0.81 (0.71-0.92), p < 0.001]. CONCLUSIONS: Initiation of S-1 adjuvant chemotherapy in resected PDAC patients within 10 weeks after surgery may offer survival benefit over later initiation.

  219. コロナ禍における人工肛門造設予定患者に対する術前の情報提供の工夫

    佐竹 ひとみ, 伊藤 由美, 高橋 真紀, 神山 篤史, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　39　(2)　70-70　2023/06

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  220. 転移性脳腫瘍切除後に胸部食道原発の腺癌が発覚し、食道切除術を施行した一例

    角掛 純一, 谷山 裕亮, 藤島 史喜, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 加藤 伸史, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　77回　291-291　2023/06

    Publisher: (NPO)日本食道学会

  221. 【切除不能胆道癌:定義・診断・治療】CY陽性胆道癌をどう取り扱うか

    中川 圭, 伊関 雅裕, 青木 修一, 佐藤 英昭, 海野 倫明

    胆と膵　44　(6)　523-526　2023/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  222. 転移性脳腫瘍切除後に胸部食道原発の腺癌が発覚し、食道切除術を施行した一例

    角掛 純一, 谷山 裕亮, 藤島 史喜, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 加藤 伸史, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　77回　291-291　2023/06

    Publisher: (NPO)日本食道学会

  223. 【イラストで見る消化器癌手術アトラス】肝胆膵 胆嚢癌に対する手術 早期胆嚢癌から進行胆嚢癌まで

    日下 彬子, 中川 圭, 伊関 雅裕, 青木 修一, 佐藤 英昭, 海野 倫明

    手術　77　(6)　931-937　2023/05

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  224. 本邦における減量・代謝改善外科の現状と課題 減量・代謝改善手術の脂肪肝改善効果 適応拡大を見据えて

    土屋 尭裕, 田中 直樹, 井本 博文, 山村 明寛, 西條 文人, 大沼 忍, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　48　(3)　313-313　2023/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  225. 私の手術手技の工夫(胸部) 胸腔鏡下食道癌手術における右胸腔の癒着剥離術の工夫

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 角掛 純一, 廣瀬 亘, 金淵 佐和, 邑並 祐人, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科系連合学会誌　48　(3)　380-380　2023/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  226. Functional Assessment of Cardiac Arrest Hepatocytes and Effect of Mechanical Perfusion on Function in a Rat Model

    Naruhito Takido, Atsushi Fujio, Hiroyasu Nishimaki, Hiroki Yamana, Takehiro Imura, Toshiaki Kashiwadate, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Transplantation Proceedings　55　(4)　1012-1015　2023/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.transproceed.2023.03.051 　

    ISSN： 0041-1345

  227. Clinical Significance of the Mac-2 Binding Protein Glycosylated Isomer as a Surrogate Marker of Graft Fibrosis After Pediatric Liver Transplantation. International-journal

    Hiroki Yamana, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　2023/04/30

    DOI： 10.1016/j.transproceed.2023.03.053 　

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    BACKGROUND: After pediatric liver transplantation, liver fibrosis may occur during long-term follow-up. Noninvasive markers for assessing this liver fibrosis are desired. Mac-2 binding protein glycosylated isomer (M2BPGi) has recently been reported as a useful biomarker for liver fibrosis. However, its usefulness in the pediatric population is yet to be established. This study investigated the clinical significance of M2BPGi levels as a surrogate marker of graft fibrosis after pediatric liver transplantation. METHODS: We retrospectively identified 96 patients who underwent pediatric liver transplantation at our institution between 1991 and 2015. The association between M2BPGi levels and other fibrosis markers was analyzed in 60 patients in whom fibrosis markers were measured. The association between fibrosis marker levels and graft fibrosis was assessed in 42 patients who underwent biopsies between 2016 and 2022. RESULTS: The M2BPGi levels were statistically correlated with the hyaluronic acid and type-IV collagen levels. None of the fibrosis markers were significantly associated with liver graft fibrosis, although the levels of these markers were slightly higher in patients with severe liver fibrosis than in those with mild fibrosis. CONCLUSIONS: The M2BPGi levels had a limited ability to assess liver graft fibrosis after pediatric liver transplantation, similar to other fibrosis markers. Further studies with larger cohorts are required to validate these findings externally.

  228. Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production. International-journal

    Mingxin Cao, Xinming Li, Duc-Anh Trinh, Shingo Yoshimachi, Kota Goto, Natsumi Sakata, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Yuxia Wang, Ryutaro Shirakawa, Hisanori Horiuchi

    The Journal of biological chemistry　104754-104754　2023/04/26

    DOI： 10.1016/j.jbc.2023.104754 　

    More details Close

    Pancreatic ductal adenocarcinoma (PDAC), caused by activating mutations in K-Ras, is an aggressive malignancy due to its early invasion and metastasis. Ral GTPases are activated downstream of Ras and play a crucial role in the development and progression of PDAC. However, the underlying mechanisms remain unclear. In this study, we investigated the mechanism of Ral-induced invasion and metastasis of PDAC cells using RalGAPβ-deficient PDAC cells with highly activated Ral GTPases. Array analysis and enzyme-linked immunosorbent assays revealed increased expression and secretion of TGF-β1 in RalGAPβ-deficient PDAC cells compared to control cells. Blockade of TGF-β1 signaling suppressed RalGAPβ deficiency-enhanced migration and invasion in vitro and metastasis in vivo to levels similar to controls. Phosphorylation of c-Jun N-terminal kinase (JNK), a repressor of TGF-β1 expression, was decreased by RalGAPβ deficiency. These results indicate that Ral contributes to invasion and metastasis of PDAC cells by elevating autocrine TGF-β1 signaling at least in part by decreasing JNK activity.

  229. 先天性代謝異常症に対するヒト羊膜上皮細胞による新規細胞移植療法の確立

    田中 美也子, 戸子台 和哲, 岡田 薫, 齋藤 昌利, 星合 哲郎, 三木 敏生, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　DP-2　2023/04

    Publisher: (一社)日本外科学会

  230. 再生医療が外科にもたらす変化 再生医療の外科診療への応用と本学で進める「羊膜プロジェクト」の現状と課題

    戸子台 和哲, 岡田 薫, 田中 美也子, 渡辺 祐記, 宇田川 輝久, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 谷山 裕亮, 赤松 大二朗, 星合 哲郎, 齋藤 昌利, 三木 敏生, 和田 基, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　SY-6　2023/04

    Publisher: (一社)日本外科学会

  231. 腹腔鏡下肝切除におけるsurgical marginについての検討

    宮澤 恒持, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 松村 宗幸, 山名 浩樹, 三頭 啓明, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-5　2023/04

    Publisher: (一社)日本外科学会

  232. 抗体療法時代における炎症性腸疾患難治例に対する外科治療戦略 クローン病手術例における術後抗体療法の至適症例群についての検討

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SY-3　2023/04

    Publisher: (一社)日本外科学会

  233. 機械学習を用いた直腸癌に対する術前化学放射線療法の効果予測

    小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-5　2023/04

    Publisher: (一社)日本外科学会

  234. 他臓器浸潤S状結腸癌(cT4b)の治療戦略(手術先行or術前化学療法)

    唐澤 秀明, 小野 智之, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-3　2023/04

    Publisher: (一社)日本外科学会

  235. 免疫統御療法が潰瘍性大腸炎の周術期に及ぼす影響

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 石田 孝宣, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-5　2023/04

    Publisher: (一社)日本外科学会

  236. 術前画像診断による側方リンパ節転移の評価と治療成績からみた側方郭清の意義

    梶原 大輝, 小野 智之, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-4　2023/04

    Publisher: (一社)日本外科学会

  237. 減量・代謝改善手術ネクストステージ 当院における減量・代謝改善手術後のRevision surgeryの現状

    井本 博文, 田中 直樹, 土屋 尭裕, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SY-6　2023/04

    Publisher: (一社)日本外科学会

  238. 傾向スコアマッチングを用いた高齢者胃癌に対する手術成績の検討

    田中 直樹, 山村 明寛, 井本 博文, 土屋 尭裕, 西條 文人, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-4　2023/04

    Publisher: (一社)日本外科学会

  239. 高齢者胃癌切除症例における予後不良因子である術後栄養障害の術前予測

    山村 明寛, 田中 直樹, 井本 博文, 土屋 堯裕, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-3　2023/04

    Publisher: (一社)日本外科学会

  240. RCTが困難なClinical Questionに対するアプローチ NCDとNCDBの利用を通して

    宮下 穣, 多田 寛, 原田 成美, 江幡 明子, 濱中 洋平, 佐藤 未来, 柳垣 美歌, 山崎 あすみ, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 石田 孝宣

    日本外科学会定期学術集会抄録集　123回　SF-8　2023/04

    Publisher: (一社)日本外科学会

  241. エストロゲン受容体陰性乳癌における細胞質内エストロゲン受容体は予後良好因子の可能性がある

    江幡 明子, 鈴木 貴, 多田 寛, 原田 成美, 濱中 洋平, 宮下 穣, 深町 佳世子, 柳垣 美歌, 進藤 晴彦, 角掛 聡子, 本成 登貴和, 山崎 あすみ, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 石田 孝宣

    日本外科学会定期学術集会抄録集　123回　DP-2　2023/04

    Publisher: (一社)日本外科学会

  242. 乳癌におけるSGLT1の発現と予後不良因子としての検討

    角掛 聡子, 岩渕 英里奈, 三木 康宏, 小野寺 好明, 多田 寛, 原田 成美, 宮下 穣, 濱中 洋平, 江幡 明子, 柳垣 美歌, 進藤 晴彦, 本成 登貴和, 山崎 あすみ, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 笹野 公伸, 鈴木 貴, 石田 孝宣

    日本外科学会定期学術集会抄録集　123回　DP-4　2023/04

    Publisher: (一社)日本外科学会

  243. 当科における若手外科医獲得のための戦略

    谷山 裕亮, 赤松 大二朗, 田中 直樹, 多田 寛, 青木 修一, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　HFT-4　2023/04

    Publisher: (一社)日本外科学会

  244. 頸部食道癌に対するDocetaxel/CDDP/5-FU併用放射線療法の治療成績

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 山内 拓郎, 大沼 忍, 海野 倫明, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　DP-3　2023/04

    Publisher: (一社)日本外科学会

  245. Up-side down stomachを呈する食道裂孔ヘルニアに対する腹腔鏡下食道裂孔ヘルニア修復術の手術成績

    佐藤 千晃, 加藤 伸史, 山内 拓郎, 小関 健, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　DP-7　2023/04

    Publisher: (一社)日本外科学会

  246. 【膵癌・胆道癌2023(下)胆道癌編-基礎・臨床の最新研究動向-】腺癌 胆嚢癌 治療 外科的切除(適応・術式)手術適応と術式選択 開腹手術

    堂地 大輔, 中川 圭, 海野 倫明

    日本臨床　81　(増刊4 膵癌・胆道癌2023(下)胆道癌編)　146-150　2023/04

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  247. Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and Decreasing Their Accumulation. International-journal Peer-reviewed

    Dan-Yang Wang, Shinobu Ohnuma, Hideyuki Suzuki, Masaharu Ishida, Kentaro Ishii, Takashi Hirosawa, Tomoaki Hirashima, Megumi Murakami, Minoru Kobayashi, Katsuyoshi Kudoh, Sho Haneda, Hiroaki Musha, Takeshi Naitoh, Michiaki Unno

    Current issues in molecular biology　45　(4)　2895-2907　2023/04/01

    DOI： 10.3390/cimb45040189 　

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    Inflammatory bowel diseases (IBDs), such as Crohn's disease or ulcerative colitis, can be treated with anti TNF-alpha (TNF-α) antibodies (Abs), but they also put patients with IBDs at risk of cancer. We aimed to determine whether the anti TNF-α Ab induces colon cancer development in vitro and in vivo, and to identify the genes involved in colitis-associated cancer. We found that TNF-α (50 ng/mL) inhibited the proliferation, migration, and invasion of HCT8 and COLO205 colon cancer cell lines and that anti TNF-α Ab neutralized TNF-α inhibition in vitro. The effects of anti TNF-α Ab, infliximab (10 mg/kg) were investigated in mouse models of colitis-associated cancer induced by intraperitoneally injected azoxymethane (AOM: 10 mg/kg)/orally administered dextran sodium sulfate (DSS: 2.5%) (AOM/DSS) in vivo. Infliximab significantly attenuated the development of colon cancer in these mice. Microarray analyses and RT-qPCR revealed that mast cell protease 1, mast cell protease 2, and chymase 1 were up-regulated in cancer tissue of AOM/DSS mice; however, those mast cell related genes were downregulated in cancer tissue of AOM/DSS mice with infliximab. These results suggested that mast cells play a pivotal role in the development of cancer associated with colitis in AOM/DSS mice.

  248. Somatostatin receptor 2 in 10 different types of human non-neoplastic gastrointestinal neuroendocrine cells. International-journal

    Hirofumi Watanabe, Fumiyoshi Fujishima, Michiaki Unno, Hironobu Sasano, Takashi Suzuki

    Pathology, research and practice　244　154418-154418　2023/04

    DOI： 10.1016/j.prp.2023.154418 　

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    Somatostatin is known to inhibit the secretion of various hormones by acting on endocrine cells through the somatostatin receptor 2 (SSTR2). Immunohistochemical evaluation of SSTR2 has become increasingly important in clinical practice to determine treatment strategies for patients with a neuroendocrine tumor (NET). Gastrointestinal (GI) tracts contain various neuroendocrine cells that constitute a diffuse endocrine system and some NETs are derived from those cells. In addition, NETs have been well known to express a variable spectrum of proteins shared by their normal cell counterparts of the specific anatomical sites. Thus, we may derive the kinetics of SSTR2 expression of NETs, including de novo expression, from the SSTR2 expression of the corresponding normal neuroendocrine cells. Therefore, a detailed study on the distribution of SSTR2 in normal human neuroendocrine cells may contribute to understanding the expression of SSTR2 in GI-NETs. However, the detailed cellular localization of SSTR2 in non-neoplastic neuroendocrine cells remains unknown. Therefore, we immunolocalized SSTR2 in neuroendocrine cells of normal human GI tracts, including the stomach, duodenum, ileum, and rectum, obtained from 41 surgically resected tissue specimens. Double immunohistochemistry of SSTR2 and hormones or hormone-associated proteins was performed. In all GI neuroendocrine cells, cell types other than D- and EC-cells demonstrated a high percentage of SSTR2-positive cases or a high double-positive ratio. In particular, EC-cells showed lower SSTR2-positive ratios in all sites. Midgut NETs, which often produce serotonin, are excellent targets for somatostatin analogs and are positive for SSTR2. Thus, we speculated that EC-cell NETs might lead to the de novo expression of SSTR2. In addition, a previous report showed high SSTR2 expression in ECL-cell NETs and gastrinomas, which could be because they are derived from neuroendocrine cells with high SSTR2 expression. This study may contribute to understanding the expression of SSTR2 in GI-NETs.

  249. Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea-Japan collaborative study.

    Hyung Sun Kim, Woojin Kim, Itaru Endo, Jin-Young Jang, Hongbeom Kim, Ki Byung Song, Dae Wook Hwang, Chang Moo Kang, Ho Kyoung Hwang, Sang-Jae Park, Sung-Sik Han, Yoo-Seok Yoon, Jae Do Yang, Ryosuke Amano, Sadaaki Yamazoe, Hiroaki Yanagimoto, Tetsuo Ajiki, Masayuki Ohtsuka, Daisuke Suzuki, Dong-Shik Lee, Yuji Kitahata, Koji Amaya, Jun Sakata, Hyung Il Seo, Junichiro Yamauchi, Yasuhiro Yabushita, Takayuki Tanaka, Naoki Sakurai, Teijiro Hirashita, Akihiko Horiguchi, Michiaki Unno, Dong Do You, Yo-Ichi Yamashita, Shogo Kobayashi, Yusuke Kyoden, Takao Ide, Hiroaki Nagano, Masafumi Nakamura, Hiroki Yamaue, Masakazu Yamamoto, Joon Seong Park

    Journal of hepato-biliary-pancreatic sciences　30　(3)　360-373　2023/03

    DOI： 10.1002/jhbp.1229 　

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    BACKGROUND: In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence-free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first study for nomograms in AOV cancer patients using retrospective data based on an international multicenter study. METHODS: A total of 2007 patients with AOV adenocarcinoma who received operative therapy between 2002 January and 2015 December in Korea and Japan were retrospectively assessed to develop a prediction model. Nomograms for 5-year OS and 3-year RFS were constructed by dividing the patients who received and who did not receive adjuvant therapy after surgery, respectively. Significant risk factors were identified by univariate and multivariate Cox analyses. Performance assessment of the four prediction models was conducted by the Harrell's concordance index (C-index) and calibration curves using bootstrapping. RESULTS: A total of 2007 and 1873 patients were collected for nomogram construction to predict 5-year OS and 3-year RFS. We developed four types of nomograms, including models for 5-year OS and 3-year RFS in patients who did not receive postoperative adjuvant therapy, and 5-year OS and 3-year RFS in patients who received postoperative adjuvant therapy. The C-indices of these nomograms were 0.795 (95% confidence interval [CI]: 0.766-0.823), 0.712 (95% CI: 0.674-0.750), 0.804 (95% CI: 0.7778-0.829), and 0.703 (95% CI: 0.669-0.737), respectively. CONCLUSIONS: This predictive model could help clinicians to choose optimal treatment and precisely predict prognosis in AOV cancer patients.

  250. 高齢者炎症性腸疾患における治療選択とリスクマネージメント 高齢者潰瘍性大腸炎の特徴と周術期管理の問題点

    神山 篤史, 大沼 忍, 海野 倫明

    日本消化器病学会雑誌　120　(臨増総会)　A123-A123　2023/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  251. クローン病の短腸症候群,複雑痔瘻に対する最新の治療

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器病学会雑誌　120　(臨増総会)　A288-A288　2023/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  252. 直腸癌に対する腹腔鏡下直腸切断術 腹臥位による会陰操作先行アプローチの治療成績の検討

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 土屋 尭裕, 井本 博文, 山村 明寛, 田中 直樹, 内藤 覚, 齋藤 達, 佐藤 将大, 中村 香織, 名久井 佑子, 西條 文人, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器病学会雑誌　120　(臨増総会)　A423-A423　2023/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  253. Molecular tracingによるIPMN由来膵退形成癌の発生機構解明

    大森 優子, 小野 裕介, 伊藤 泰斗, 伊達 文子, 青山 弥生, 水上 裕輔, 森川 孝則, 海野 倫明, 古川 徹

    日本病理学会会誌　112　(1)　297-297　2023/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  254. Distinguishing Killian-Jamieson diverticulum from Zenker's diverticulum. International-journal

    Yuki Watanabe, Yusuke Taniyama, Ken Koseki, Hirotaka Ishida, Yohei Ozawa, Hiroshi Okamoto, Chiaki Sato, Michiaki Unno, Takashi Kamei

    Surgical case reports　9　(1)　21-21　2023/02/10

    DOI： 10.1186/s40792-023-01599-7 　

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    BACKGROUND: Killian-Jamieson diverticulum, which is a relatively rare pharyngoesophageal diverticulum, is difficult to distinguish from Zenker's diverticulum. Because major points of the relevant surgical procedures for these two entities differ, it is important to make an accurate diagnosis. We herein report a case of Killian-Jamieson diverticulum initially diagnosed as Zenker's diverticulum. CASE PRESENTATION: A 56-year-old man complaining of discomfort during swallowing was diagnosed with pharyngoesophageal diverticulum. He was initially diagnosed with Zenker's diverticulum before surgery, but the diverticulum actually arose from the left side of the esophageal wall, at the level of the cricoid cartilage and below the cricopharyngeal muscle. We therefore ultimately diagnosed this case as Killian-Jamieson diverticulum during surgery, and were able to preserve the muscle above the diverticulum, which would normally have to be cut when treating a case of Zenker's diverticulum. CONCLUSION: To make an accurate diagnosis, clinical and surgical findings are important to consider, including the location of the diverticulum and the relationship between the diverticula and cricopharyngeal muscles or between the diverticula, thyroid cartilage and cricoid cartilage.

  255. TWIST1 is a prognostic factor for neoadjuvant chemotherapy for patients with resectable pancreatic cancer: a preliminary study.

    Sho Fujiwara, Yuriko Saiki, Shinichi Fukushige, Mie Yamanaka, Masaharu Ishida, Fuyuhiko Motoi, Michiaki Unno, Akira Horii

    Surgery today　2023/02/10

    DOI： 10.1007/s00595-023-02655-3 　

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    Recent advances in the development of chemotherapies have helped improve the prognosis of pancreatic ductal adenocarcinoma (PDAC). However, predicting factors for the outcomes of chemotherapies (either gemcitabine or S-1) have not yet been established. We analyzed the expression of 4 major epithelial-to-mesenchymal transition-inducing transcription factors in 38 PDAC patients who received adjuvant chemotherapy after radical resection to examine the association with patients' prognoses. The TWIST1-positive group showed a significantly poorer prognosis than the TWIST1-negative group for both the relapse-free survival (median survival time [MST] of 8.9 vs. 18.5 months, P = 0.016) and the overall survival (MST of 15.2 vs. 33.4 months, P = 0.023). A multivariate analysis revealed that TWIST1 positivity was an independent prognostic factor for a poor response to adjuvant chemotherapies (hazard ratio 2.61; 95% confidence interval 1.10-6.79; P = 0.029). These results suggest that TWIST1 can be utilized as an important poor prognostic factor for radically resected PDAC patients with adjuvant chemotherapy, potentially including neoadjuvant therapy using these agents.

  256. 肝部下大静脈欠損と内臓逆位を合併した胆道閉鎖症に対して脳死分割肝グラフトを用いた再肝移植の一例

    山名 浩樹, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 宮崎 勇希, 三頭 啓明, 戸子台 和哲, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　214回　91-91　2023/02

    Publisher: 日本消化器病学会-東北支部

  257. 緊急手術を施行した左室補助循環装置装着中の急性胆嚢炎の1例

    三頭 啓明, 宮澤 恒持, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 松村 宗幸, 山名 浩樹, 海野 倫明, 亀井 尚

    日本腹部救急医学会雑誌　43　(2)　451-451　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  258. Oncologic Emergencyに対する二期的腹腔鏡下・ロボット支援下手術の実際 回腸人工肛門造設下での腹腔鏡下大腸切除の工夫

    唐澤 秀明, 小野 智之, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　330-330　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  259. 炎症性腸疾患診療における内科と外科の連携アプローチ 免疫統御療法時代の潰瘍性大腸炎の外科治療

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 大沼 忍, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　355-355　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  260. 閉塞性左側大腸癌に対する至適術前減圧法

    梶原 大輝, 小野 智之, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　370-370　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  261. Stage II大腸癌の再発リスク因子の検討

    齋藤 達, 神山 篤史, 佐藤 将大, 内藤 覚, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 渡辺 和宏, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　76　(2)　189-189　2023/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  262. 切除不能および切除困難大腸癌症例における術前化学療法の治療成績と課題

    佐藤 将大, 神山 篤史, 齋藤 達, 内藤 覚, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 渡辺 和宏, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　76　(2)　196-196　2023/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  263. 腹腔鏡下括約筋間直腸切除術の治療成績

    内藤 覚, 神山 篤史, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 渡辺 和宏, 大沼 忍, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　76　(2)　207-207　2023/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  264. ミスマッチ修復欠損大腸癌の免疫染色によるユニバーサルスクリーニングの成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　76　(2)　244-244　2023/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  265. 膵癌術後,上行結腸に発生した異所性静脈瘤破裂に対して緊急内視鏡的硬化療法により救命しえた1例

    猪股 優志, 内藤 健夫, 下山 雄丞, 諸井 林太郎, 志賀 永嗣, 角田 洋一, 加宅田 公子, 大原 祐樹, 浅野 直喜, 青木 修一, 海野 倫明, 正宗 淳

    日本消化器内視鏡学会東北支部例会　169回　119-119　2023/02

    Publisher: 日本消化器内視鏡学会-東北支部

  266. 血液透析患者に対する亜全胃温存膵頭十二指腸切除術4例の検討

    平野 直大, 伊関 雅裕, 日下 彬子, 青木 修一, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　441-441　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  267. 胆管炎を来した胆嚢出血に対する胆嚢摘出術の1例

    秋重 尚貴, 堂地 大輔, 日下 彬子, 青木 修一, 井上 亨悦, 伊関 雅裕, 中山 瞬, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　539-539　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  268. A Case of an Elderly Patient Who Underwent Conversion Resection for Pancreatic Cancer with Positive Peritoneal Cytology

    Naohiro Hirano, Shuichi Aoki, Masamichi Mizuma, Kei Nakagawa, Koetsu Inoue, Masahiro Iseki, Shun Nakayama, Daisuke Douchi, Takayuki Miura, Masaharu Ishida, Hideo Ohtsuka, Takanori Morikawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer &amp; chemotherapy　50　(2)　224-226　2023/02/01

    ISSN： 0385-0684

  269. 超長鎖脂肪酸は膵切後栄養状態の指標となる

    石田 晶玄, 伊関 雅裕, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    学会誌JSPEN　5　(Suppl.2)　26-27　2023

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  270. 膵癌術前化学療法が低亜鉛血症を引き起こす

    伊関 雅裕, 水間 正道, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 堂地 大輔, 三浦 孝之, 前田 晋平, 石田 晶玄, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    学会誌JSPEN　5　(Suppl.2)　27-28　2023

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  271. 膵切後脂肪肝発生における周術期栄養状態およびサルコペニアの栄養についての検討

    小林 千紗, 石田 晶玄, 國米 崇, 佐藤 英昭, 日下 彬子, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 前田 晋平, 水間 正道, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    学会誌JSPEN　5　(Suppl.2)　29-30　2023

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  272. 周術期の栄養と運動は短期・長期成績をどう変えるか 術前の栄養不良・骨格筋量が肝移植レシピエントに与える影響

    三頭 啓明, 藤尾 淳, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 山名 浩樹, 海野 倫明, 亀井 尚

    外科と代謝・栄養　57　(3)　116-116　2023

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  273. E-learningを併用した地方講習会開催の試み

    神山 篤史, 渡辺 和宏, 高橋 真紀, 渡辺 涼子, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　39　(1)　231-231　2023/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  274. 翻転困難な浮腫腸管ストーマ造設におけるナメクジ法(slug法)の手技

    渡辺 和宏, 神山 篤史, 高橋 真紀, 渡辺 涼子, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　39　(1)　256-256　2023/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  275. 潰瘍性大腸炎関連大腸癌の傾向

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 小林 実, 初沢 悠人, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　76　(1)　60-60　2023/01

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  276. 初回内視鏡治療を施行した大腸SM癌の臨床病理学的検討

    市川 英孝, 大沼 忍, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 山村 明寛, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　76　(1)　92-92　2023/01

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  277. 短期治療成績からみた導入初期のロボット支援下直腸手術の課題

    神山 篤史, 大沼 忍, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　76　(1)　109-109　2023/01

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  278. 70歳以上高齢者Stage II/III大腸癌に対する術後補助化学療法の現状と成績

    梶原 大輝, 大沼 忍, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　76　(1)　115-115　2023/01

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  279. ESSENSEによる周術期管理～わが国におけるESSENSEのさらなる普及を目指して～ 患者満足をともなった術後回復促進に向けて 食道癌周術期の取り組みと成果

    小澤 洋平, 岡本 宏史, 谷山 裕亮, 佐藤 千晃, 石田 裕嵩, 加藤 伸史, 角掛 純一, 廣瀬 亘, 篠崎 康晴, 大沼 忍, 海野 倫明, 亀井 尚

    外科と代謝・栄養　57　(3)　69-69　2023

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  280. 食道癌手術における空腸瘻を用いた早期経腸栄養の効果とリスク因子の検討

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 金淵 佐和, 邑並 祐人, 布施川 一樹, 大沼 忍, 海野 倫明, 亀井 尚

    学会誌JSPEN　5　(Suppl.2)　40-41　2023

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  281. 過去から未来に繋げる災害医療と外科医の役割 過去から学ぶ大規模災害における外科医と被災地外科医局の役割 東日本大震災からCOVID-19まで

    宮城 重人, 石井 正, 赤松 大二朗, 原 康之, 谷山 裕亮, 田中 直樹, 多田 寛, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会雑誌　124　(1)　128-130　2023/01

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  282. 他科手術と血管外科の関わり(腫瘍外科時の血行再建、Rescue Surgeryなど) 根治的腫瘍切除を目指した下大静脈合併切除についての検討

    鈴木 峻也, 赤松 大二朗, 芹澤 玄, 梅津 道久, 小笠原 紀信, 高橋 宏和, 木村 俊作, 清水 港太, 石田 孝宣, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　32　(Suppl.)　VS1-7　2023

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  283. 血管型エーラス・ダンロス症候群患者8例の臨床経過と血管内治療

    小笠原 紀信, 赤松 大二朗, 芹澤 玄, 梅津 道久, 鈴木 峻也, 高橋 宏和, 木村 俊作, 清水 港太, 大沼 忍, 石田 孝宜, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　32　(Suppl.)　RO4-3　2023

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  284. Type 2 Endoleakを伴う瘤径拡大症例の治療適応に関する検討

    芹澤 玄, 清水 港太, 木村 俊作, 小笠原 紀信, 高橋 宏和, 鈴木 俊也, 梅津 道久, 赤松 大二朗, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　32　(Suppl.)　O14-4　2023

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  285. ESSENSEによる周術期管理～わが国におけるESSENSEのさらなる普及を目指して～ 患者満足をともなった術後回復促進に向けて 食道癌周術期の取り組みと成果

    小澤 洋平, 岡本 宏史, 谷山 裕亮, 佐藤 千晃, 石田 裕嵩, 加藤 伸史, 角掛 純一, 廣瀬 亘, 篠崎 康晴, 大沼 忍, 海野 倫明, 亀井 尚

    外科と代謝・栄養　57　(3)　69-69　2023

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  286. Chronic Glucocorticoid Use is a Potential Risk Factor for Delayed Pancreatic Fistula after Laparoscopic Distal Pancreatectomy: A Retrospective Analysis

    Koetsu Inoue, Takanori Morikawa, Masaharu Ishida, Takayuki Miura, Ryosuke Kashiwagi, Takashi Kokumai, Shuichi Aoki, Masahiro Iseki, Shun Nakayama, Daisuke Douchi, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    The Tohoku Journal of Experimental Medicine　2023

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2023.j072 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  287. Ideal Duration of Pretreatment Using a Gelatin Hydrogel Nonwoven Fabric Prior to Subcutaneous Islet Transplantation. International-journal

    Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

    Cell transplantation　32　9636897231186063-9636897231186063　2023

    DOI： 10.1177/09636897231186063 　

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    Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet engraftment in comparison with intraportal islet transplantation. We herein investigated whether the duration of pretreatment using GHNF affected the outcome of subcutaneous islet transplantation. A silicone spacer with GHNF was implanted into the subcutaneous space of healthy mice at 2, 4, 6, or 8 weeks before transplantation, and then diabetes was induced 7 days before transplantation. Syngeneic islets were transplanted into the pretreated space. Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, inflammatory mediators, and gene expression were evaluated. The 6-week group showed significantly better blood glucose changes than the other groups (P < 0.05). The cure rate of the 6-week group (60.0%) was the highest among the groups (2-week = 0%, 4-week = 50.0%, 8-week = 15.4%). The number of von Willebrand factor (vWF)-positive vessels in the 6-week group was significantly higher than in the other groups at pre-islet and post-islet transplantation (P < 0.01 [vs 2-and 4-week groups] and P < 0.05 [vs all other groups], respectively). Notably, this beneficial effect was also observed when GHNF was implanted into diabetic mice injected with streptozotocin 7 days before GHNF implantation. The positive rates for laminin, collagen III, and collagen IV increased as the duration of pretreatment became longer and were significantly higher in the 8-week group (P < 0.01). Inflammatory mediators, including interleukin (IL)-1b, granulocyte colony-stimulating factor (G-CSF), and interferon (IFN)-γ, were gradually downregulated according to the duration of GHNF pretreatment and re-elevated in the 8-week group. Taken together, the duration of GHNF pretreatment apparently had an impact on the outcomes of subcutaneous islet transplantation, and 6 weeks appeared to be the ideal duration. Islet graft revascularization, extracellular matrix compensation of the islet capsule, and the inflammatory status at the subcutaneous space would be crucial factors for successful subcutaneous islet transplantation.

  288. PREDICTORS OF EARLY AND LATE MORTALITY AFTER THE TREATMENT FOR EARLY GASTRIC CANCERS

    OGATA Yohei, HATTA Waku, OHARA Yuki, KOIKE Tomoyuki, ABE Hiroko, SAITO Masahiro, JIN Xiaoyi, KANNO Takeshi, UNO Kaname, ASANO Naoki, IMATANI Akira, YAMAMURA Akihiro, TANAKA Naoki, KAMEI Takashi, UNNO Michiaki, NAKAMURA Tomohiro, NAKAYA Naoki, MASAMUNE Atsushi

    GASTROENTEROLOGICAL ENDOSCOPY　65　(2)　162-172　2023

    Publisher: Japan Gastroenterological Endoscopy Society

    DOI： 10.11280/gee.65.162 　

    ISSN： 0387-1207

    eISSN： 1884-5738

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    Objectives: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. Methods: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. Results: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. Conclusion: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality

  289. GATA6 and CK5 stratify the survival of patients with pancreatic cancer undergoing neoadjuvant chemotherapy

    Takashi Kokumai, Yuko Omori, Masaharu Ishida, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Maeda Chiho, Yusuke Ono, Yusuke Mizukami, Shin Miura, Kiyoshi Kume, Atsushi Masamune, Takanori Morikawa, Michiaki Unno, Toru Furukawa

    Modern Pathology　36　(5)　100102-100102　2023/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.modpat.2023.100102 　

    ISSN： 0893-3952

  290. Impact of S‐1 adjuvant chemotherapy longer than 6 months on survival in patients with resected pancreatic cancer: a nationwide survey by the Japan Pancreas Society based on real‐world data

    Yoshito Tomimaru, Hidetoshi Eguchi, Yosuke Inoue, Yuichi Nagakawa, Akihiro Ohba, Hideki Takami, Michiaki Unno, Tomohisa Yamamoto, Shoji Kawakatsu, Tsuyoshi Hayashi, Ryota Higuchi, Hirohisa Kitagawa, Satoshi Hattori, Tsutomu Fujii, Yoshiki Hirooka, Hisato Igarashi, Masayuki Kitano, Tamotsu Kuroki, Atsushi Masamune, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshihisa Tsuji, Hiroki Yamaue, Sohei Satoi, Yoshifumi Takeyama

    Cancer　129　(5)　728-739　2022/12/12

    Publisher: Wiley

    DOI： 10.1002/cncr.34580 　

    ISSN： 0008-543X

    eISSN： 1097-0142

  291. 在宅看護師のためのストーマケア講習会の開催と今後の課題

    柴崎 真澄, 熊谷 英子, 舟山 裕士, 大網 さおり, 大内 淑子, 小野 友美, 木幡 真利子, 蛭田 理絵, 村田 博子, 石川 奈津江, 神山 篤史, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　38　(3)　163-176　2022/12

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  292. 双孔式回腸瘻の口側脚が反転して嵌頓した腸重積症の1例

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　38　(3)　179-180　2022/12

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  293. ストーマ外来見学の試み 病棟でのストーマケア質向上を目指して

    藤本 あゆみ, 狩野 修代, 八巻 佳代子, 石橋 凪沙, 高橋 真紀, 佐竹 ひとみ, 佐藤 裕子, 神山 篤史, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　38　(3)　180-180　2022/12

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  294. ロボット支援下直腸切除術後の排便排尿機能障害の検討

    梶原 大輝, 小野 智之, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本内視鏡外科学会雑誌　27　(7)　782-782　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  295. 術前治療後・回腸人工肛門造設下でのCo-axial settingによる腹腔鏡下直腸切除術

    唐澤 秀明, 小野 智之, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本内視鏡外科学会雑誌　27　(7)　1134-1134　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  296. 局所進行下部直腸癌に対する術前化学放射線療法の短期治療成績 手術アプローチ別の検討

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 内藤 覚, 佐藤 将大, 名久井 佑子, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　27　(7)　1348-1348　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  297. クローン病における穿孔を伴わない回盲部病変に対する腹腔鏡手術の検討

    小林 実, 渡辺 和宏, 小野 智之, 梶原 大輝, 唐澤 秀明, 神山 篤史, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本内視鏡外科学会雑誌　27　(7)　2490-2490　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  298. 炎症性腸疾患に対する低侵襲手術:開腹vs腹腔鏡 用手補助下と比較した腹腔鏡補助下大腸全摘・回腸嚢肛門吻合術の治療成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 大沼 忍, 海野 倫明

    日本内視鏡外科学会雑誌　27　(7)　2769-2769　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  299. [A Case of Laparoscopic Abdominoperineal Resection and Perineal Reconstruction for Signet-Ring Cell Carcinoma with Skin Invasion Derived from the Anal Gland].

    Kaori Nakamura, Tomoyuki Ono, Minoru Kobayashi, Taiki Kajiwara, Hideaki Karasawa, Atsushi Kohyama, Kazuhiro Watanabe, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　49　(13)　1876-1878　2022/12

    ISSN： 0385-0684

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    A 56-year-old man was referred to our hospital with an awareness of anal tumor. The tumor extended from the anal verge to the back of left testicle. Colonoscopy showed no tumor in the rectum and the anal canal. Biopsy showed mucus- producing adenocarcinoma(sig), and we diagnosed anal canal adenocarcinoma with immunostaining. Laparoscopic abdominoperineal rectal resection and perineal reconstruction with the V-Y fasciocutaneous flap closure technique. The patient had no major postoperative complications, and was discharged on 23rd postoperative day. Pathological examination revealed that the tumor was pT3N0M0, pStage ⅡB. The patient received adjuvant chemotherapy with CAPOX and has survived 12 months without recurrence. Immunostaining may be used to diagnose the signet-ring cell carcinoma without tumor of anal canal. In addition, reconstruction of the perineum for large anal tumors is useful.

  300. [A Case of Robot-Assisted Abdominoperineal Resection with Prostatectomy for Locally Advanced Rectal Cancer].

    Tatsushi Saito, Hideaki Karasawa, Naoki Kawamorita, Hidetaka Ichikawa, Tomoyuki Ono, Minoru Kobayashi, Taiki Kajiwara, Atsushi Kohyama, Kazuhiro Watanabe, Takashi Kamei, Shinobu Onuma, Akihiro Ito, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　49　(13)　1690-1692　2022/12

    ISSN： 0385-0684

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    The patient was referred to our hospital because of bloody stool and anorectal pain, and a colonoscopy revealed a tumor in the lower rectum. Although no distant metastasis was found, the tumor was suspected to have invaded the distal prostate. Neoadjuvant chemoradiotherapy(45 Gy/25 Fr with S-1)resulted in tumor shrinkage and symptomatic improvement, however, the primary tumor remained in close proximity to the prostate and urethra. Thus, we performed a robot-assisted abdominoperineal resection and Retzius-sparing prostatectomy in collaboration with the urology department. The surgical margins were negative and radical resection was achieved. Although minor vesicourethral anastomotic leakage was observed, it recovered conservatively. The patient has been alive 1 year postoperatively without recurrence. The patient initially had urinary incontinence, but it gradually improved. Although a total pelvic resection could have been considered, the robot-assisted surgery made it possible to preserve the urinary tract. The future application of robot-assisted surgery in extended surgery is expected.

  301. 若年女性のリンパ節転移を伴う多発胃GISTの1例

    岡本 浩二, 山村 明寛, 田中 直樹, 井本 博文, 土屋 尭裕, 山崎 有人, 川名 友美, 佐々木 啓迪, 添田 敏寛, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    癌と化学療法　49　(13)　1850-1852　2022/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  302. [A Case of Multiple Gastric GIST with Lymph Nodes Metastases in a Young Woman].

    Koji Okamoto, Akihiro Yamamura, Naoki Tanaka, Hirofumi Imoto, Takahiro Tsuchiya, Yuto Yamazaki, Tomomi Kawana, Hiromichi Sasaki, Toshihiro Soeta, Fumito Saijo, Takanori Morikawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　49　(13)　1850-1852　2022/12

    ISSN： 0385-0684

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    A 21-year-old woman with bloody stool was referred to our hospital with multiple submucosal tumors at the posterior and anterior wall of the gastric angle under upper gastrointestinal endoscopy. Both of the tumors were diagnosed with gastric gastrointestinal stromal tumor(GIST)by EUS-FNA, then laparoscopic distal gastrectomy with D1 lymph node dissection was performed. The size of those tumors were 47 mm and 15 mm respectively, and pathological examination revealed multiple lymph nodes metastases. Neither KIT nor PDGFRA mutation was found. She had received postoperative adjuvant chemotherapy with imatinib mesylate for 3 years. No sign of recurrence has been confirmed thereafter. GISTs in young adults are rare and their oncological features are considered to be different from common type of GIST.

  303. Upside down stomachを呈する食道裂孔ヘルニアに対する腹腔鏡下食道裂孔ヘルニア修復術の手技の工夫と治療成績の検討

    佐藤 千晃, 山内 拓郎, 加藤 伸史, 小関 健, 石田 裕嵩, 小澤 洋平, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　27　(7)　548-548　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  304. 陽子線治療後の再発食道癌に対して胸腔鏡下食道切除術を施行した3例

    茂住 武尊, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　27　(7)　1203-1203　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  305. 胃癌・食道癌に対するロボット支援手術教育の工夫 ロボット支援下食道切除術における次世代への教育

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　27　(7)　1278-1278　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  306. 当科の低侵襲食道癌手術における術者育成と術後成績の検討

    石田 裕嵩, 谷山 裕亮, 山内 拓郎, 加藤 伸史, 小関 健, 小澤 洋平, 岡本 宏史, 佐藤 千晃, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　27　(7)　1723-1723　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  307. Salvage手術に対しロボット支援下食道切除術を施行した4例

    東本 郁, 谷山 裕亮, 岡本 宏史, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　27　(7)　1983-1983　2022/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  308. 左右異時性に発生した胃癌のKrukenberg腫瘍に対し二度にわたりR0切除した1例

    添田 敏寛, 山村 明寛, 田中 直樹, 井本 博文, 土屋 尭裕, 永井 智之, 重田 昌吾, 渡邊 裕文, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    癌と化学療法　49　(13)　1832-1834　2022/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  309. 皮膚浸潤を来した肛門管印環細胞癌に対して会陰再建を伴う腹腔鏡下直腸切断術を施行した1例

    中村 香織, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    癌と化学療法　49　(13)　1876-1878　2022/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  310. 局所進行直腸癌に対しロボット支援下に前立腺全摘術を併施し骨盤内臓全摘術を回避した1例

    齋藤 達, 唐澤 秀明, 川守田 直樹, 市川 英孝, 小野 智之, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 伊藤 明宏, 海野 倫明

    癌と化学療法　49　(13)　1690-1692　2022/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  311. 膵頭十二指腸切除術における膵外分泌機能検査(PFD試験)の意義

    石田 晶玄, 森川 孝則, 宮崎 健人, 日下 彬子, 青木 修一, 伊関 雅裕, 井上 亨悦, 堂地 大輔, 中山 瞬, 三浦 孝之, 大塚 英郎, 水間 正道, 中川 圭, 亀井 尚, 海野 倫明

    学会誌JSPEN　4　(Suppl.2)　26-26　2022/12

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  312. Negative prognostic impact of sarcopenia before and after neoadjuvant chemotherapy for pancreatic cancer. International-journal

    Mitsuhiro Shimura, Masamichi Mizuma, Fuyuhiko Motoi, Akiko Kusaka, Shuichi Aoki, Masahiro Iseki, Koetsu Inoue, Daisuke Douchi, Shun Nakayama, Takayuki Miura, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　2022/11/28

    DOI： 10.1016/j.pan.2022.11.010 　

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    OBJECTIVES: To elucidate the prognostic impact of sarcopenia before and after neoadjuvant chemotherapy (NAC) for pancreatic cancer (PC). METHODS: We retrospectively studied 75 consecutive PC patients who underwent neoadjuvant gemcitabine plus S-1 combination therapy followed by pancreatectomy between 2008 and 2016. According to the skeletal muscle volume index (SMI), the patients were divided into the muscle attenuation group (MAG) and normal group (NG) before or after NAC. Prognostic factors for overall survival (OS) were analyzed by Cox proportional hazards models. RESULTS: The MAG showed significantly poorer OS than the NG before and after NAC. Pre-NAC, median OS was 20.0 months in the MAG versus 49.0 months in the NG (p = 0.006). Post-NAC, median OS was 21.3 months in the MAG versus 48.8 months in the NG (p = 0.014). Multivariate analysis, excluding muscle attenuation after NAC because of confounding factors and lower hazard ratio (2.08, 95% confidence interval: 1.14-3.78, p = 0.016) than that before NAC (2.14, 1.23-3.70, p = 0.007) by univariate analysis, revealed the following independent prognostic factors: muscle attenuation pre-NAC (2.25, 1.26-4.05, p = 0.007); borderline resectability (1.96, 1.04-3.69, p = 0.038); operative blood loss (2.60, 1.38-4.88, p = 0.003); and distant metastasis (3.31, 1.40-7.82, p = 0.006). CONCLUSIONS: Sarcopenia before and after NAC for PC is suggested to be a poor prognostic factor, with a stronger impact before than after NAC.

  313. Reducing relapse through maintenance steroid treatment can decrease the cancer risk in patients with IgG4-sclerosing cholangitis : based on a Japanese nationwide study. International-journal

    Kensuke Kubota, Terumi Kamisawa, Takahiro Nakazawa, Atsushi Tanaka, Itaru Naitoh, Yusuke Kurita, Hajime Takikawa, Michiaki Unno, Shigeyuki Kawa, Atsushi Masamune, Seiji Nakamura, Kazuichi Okazaki

    Journal of gastroenterology and hepatology　38　(4)　556-564　2022/11/20

    DOI： 10.1111/jgh.16066 　

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    OBJECTIVE: IgG4-related sclerosing cholangitis (IgG4-SC) is recognized as a benign steroid-responsive disease; however, little is known about the risk of development of cancer in patients with IgG4-SC and about how to counter this risk. DESIGN: We conducted a retrospective review of the data of 924 patients with IgG4-SC selected from a Japanese nationwide survey. The incidence, type of malignancy, and risk of malignancy in these patients were examined. Then, the standardized incidence ratio (SIR) of cancer in patients with IgG4-SC was calculated. RESULTS: Relapse was recognized in 19.7% (182/924) of patients, and cancer development was noted in 15% (139/924) of patients. Multivariate analysis identified only relapse as an independent risk factor for the development of cancer. In most of these patients with pancreato-biliary cancer, the cancer developed within 8 years after the diagnosis of IgG4-SC. The SIR for cancer after the diagnosis of IgG4-SC was 12.68 (95% confidence interval [CI] 6.89-8.79). The SIRs of cancers involving the biliary system and pancreas were 27.35 and 18.43, respectively. The cumulative survival rate was significantly better in the group that received maintenance steroid treatment (MST) than in the group that did not; thus, MST influenced the prognosis of these patients. CONCLUSION: Among the cancers, the risk of pancreatic and biliary cancers is the highest in these patients. Because of the elevated cancer risk, surveillance after the diagnosis and management to prevent relapse are important in patients with IgG4-SC to reduce the risk of development of cancer.

  314. Deliberation on Deferred Cytoreductive Nephrectomy and Postoperative Treatment for Advanced Renal Cell Carcinoma: A Case Report

    Takuya Nakagawa, Yoshihide Kawasaki, Satoko Sato, Hiromichi Katayama, Yohei Satake, Shuichi Shimada, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Atsushi Kohyama, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Akihiro Ito

    Case Reports in Oncology　15　(3)　1014-1020　2022/11/08

    Publisher: S. Karger AG

    DOI： 10.1159/000527089 　

    eISSN： 1662-6575

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    In a rare case, free from systemic therapy, deferred cytoreductive nephrectomy was implemented in treating an advanced renal cell carcinoma with liver, lung, and splenic colon metastases. A 59-year-old man diagnosed with advanced renal cell carcinoma underwent deferred cytoreductive nephrectomy due to a partial response to systemic treatment after a period of 1 year. After the surgery, no additional treatment was implemented. Furthermore, after 10 months, the patient had no recurrence of renal cell carcinoma. Through a review of this case and deferred cases in the current literature, we could emphasize the importance of image evaluation and pathological findings as an indication for surgery and subsequent treatment options. However, there is room for debate with regards to the indications for deferred cytoreductive nephrectomy as well as a therapeutic strategy after the surgery. This report discusses the significance of deferred cytoreductive nephrectomy in terms of prognosis and quality-of-life improvement in advanced renal cancer.

  315. GoTo 100yr企画 老化のメカニズム 人生100年時代における臓器移植診療の課題と展望

    戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 和田 基, 海野 倫明, 後藤 昌史, 亀井 尚

    Organ Biology　29　(3)　63-63　2022/11

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  316. Probable posttransplant lymphoproliferative disorder after pediatric living donor liver transplantation: Is a biopsy still needed? International-journal

    Muneyuki Matsumura, Shigehito Miyagi, Kazuaki Tokodai, Toshiaki Kashiwadate, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Yoshikatsu Saito, Norifumi Kanai, Michiaki Unno, Takashi Kamei

    Clinical case reports　10　(11)　e6454　2022/11

    DOI： 10.1002/ccr3.6454 　

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    Posttransplant lymphoproliferative disorder (PTLD) is a complication of solid organ transplantation and is associated with Epstein-Barr virus (EBV). Recently, EBV-related PTLD was defined as probable PTLD or proven PTLD. Probable PTLD involves significant lymphadenopathy, hepatosplenomegaly, or other end-organ manifestations, without a histological diagnosis, together with significant EBV DNAemia. Proven PTLD is the detection of EBV-encoded proteins in a tissue specimen, together with symptoms and/or signs originating from the affected organ. Probable PTLD after pediatric liver transplantation has not been well documented. Therefore, here, we aimed to describe cases of five pediatric patients with probable PTLD after liver transplantation, who were successfully treated with preemptive immunosuppression reduction with or without rituximab. All five patients (age range, 1-4 years; two girls and three boys) had EBV DNAemia. Three patients developed probable PTLD within 12 months of transplantation. Further, three patients had a significantly high EBV viral load, but the other two patients with lymphadenopathy and end-organ manifestation had a relatively low EBV viral load. Early onset pediatric PTLD with significant EBV DNAemia is almost universally EBV-related. Biopsy was not performed in any patient due to the relative inaccessibility of the lesion and young age of the patients. If the patient's symptoms are too mild, if excisional biopsy is too difficult to perform, or if the patient is too sick to undergo an invasive procedure, initiating preemptive treatment without a histological diagnosis could be the treatment option.

  317. 減量・代謝改善手術の最新エビデンス スリーブ状胃切除術後の切除断端縫合および胃管固定の意義

    井本 博文, 田中 直樹, 土屋 尭裕, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　28　(Suppl.)　202-202　2022/11

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  318. 減量・代謝改善手術における術中・術後合併症ビデオセッション:Okinawa Hot Movies 減量・代謝改善手術後の術後出血の傾向と対策

    田中 直樹, 井本 博文, 土屋 尭裕, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　28　(Suppl.)　243-243　2022/11

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  319. 当科における腹腔鏡下スリーブ状胃切除術後の周術期管理の工夫

    土屋 尭裕, 田中 直樹, 井本 博文, 山村 明寛, 川名 友美, 佐々木 啓迪, 添田 敏寛, 岡本 浩二, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　28　(Suppl.)　302-302　2022/11

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  320. 上腕動脈の塞栓閉塞を伴う動脈性胸郭出口症候群の1例

    小笠原 紀信, 赤松 大二朗, 芹澤 玄, 梅津 道久, 鈴木 峻也, 高橋 宏和, 木村 俊作, 清水 港太, 相澤 俊峰, 大沼 忍, 石田 孝宜, 海野 倫明, 亀井 尚

    血管外科　41　(1)　72-78　2022/11

    Publisher: 血管外科症例検討会

  321. Diverse and divergent functions of IL-32β and IL-32γ isoforms in the regulation of malignant pleural mesothelioma cell growth and the production of VEGF-A and CXCL8

    Muneo Numasaki, Koyu Ito, Kiyoshi Takagi, Kengo Nagashima, Hirotsugu Notsuda, Hirokazu Ogino, Rika Ando, Yoshihisa Tomioka, Takashi Suzuki, Yoshinori Okada, Yasuhiko Nishioka, Michiaki Unno

    Cellular Immunology　104652-104652　2022/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.cellimm.2022.104652 　

    ISSN： 0008-8749

  322. Syndrome of inappropriate secretion of antidiuretic hormone after total proctocolectomy for ulcerative colitis.

    Mengge Chen, Atsushi Kohyama, Kazuhiro Watanabe, Hideaki Karasawa, Taiki Kajiwara, Minoru Kobayashi, Hidetaka Ichikawa, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Clinical journal of gastroenterology　2022/10/24

    DOI： 10.1007/s12328-022-01725-2 　

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    We report a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after total proctocolectomy followed with ileal pouch-anal anastomosis (TPC-IPAA) for ulcerative colitis (UC). The patient was a 46-year-old woman. She was diagnosed with UC of pancolitis in 2000. High grade dysplasia was detected in the transverse colon after a surveillance colonoscopy in 2021. She underwent laparoscopy-assisted TPC-IPAA. On the sixth postoperative day, she had a decreased level of consciousness that worsened on the following day. Her laboratory data showed a serum sodium level of 108 mEq/L and the plasma osmolality was 234 mOsm/kg. We did not find any other abnormalities in the laboratory examination that could cause hyponatremia. Computed tomography scan showed no central nervous system disturbances such as a pituitary tumor, antidiuretic hormone-producing tumors, or pulmonary diseases. The patient was diagnosed with Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) caused by surgical invasion. We started to administer 3% sodium chloride slowly to improve the hyponatremia. Her serum sodium level became normal and stable. Although it is rare for SIADH to be caused by abdominal surgery, if hyponatremia is observed after surgery, the possibility of postoperative SIADH should be considered.

  323. Esophageal Intramural Pseudodiverticulosis Diagnosed by Combining Esophagogastroduodenoscopy, Esophagography, and High-resolution manometry: A Case Report.

    Atsushi Kunimitsu, Naoto Ujiie, Chiaki Sato, Yusuke Taniyama, Hiroshi Okamoto, Toshiaki Fukutomi, Yohei Ozawa, Shinobu Ohnuma, Michiaki Unno, Takashi Kamei

    Internal medicine (Tokyo, Japan)　2022/10/12

    DOI： 10.2169/internalmedicine.0337-22 　

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    Esophageal intramural pseudodiverticulosis (EIPD) is a rare disease. A 78-year-old man with dysphagia presented to our hospital. The presence of diffuse esophageal spasm was suspected by his primary-care doctor. High-resolution manometry (HRM) showed no abnormal findings. The patient was diagnosed with EIPD and Candida esophagitis, by esophagogastroduodenoscopy (EGD) and esophagography. His symptoms improved after symptomatic treatment for Candida esophagitis with oral administration of an antifungal drug. EIPD should be considered in patients with dysphagia; EGD and esophagography should be performed when diagnosing EIPD.

  324. 羊膜由来幹細胞と膵島の門脈内共移植による移植後膵島生着促進の試み

    岡田 薫, 戸子台 和哲, 星合 哲郎, 齋藤 昌利, 海野 倫明, 三木 敏生, 後藤 昌史, 亀井 尚

    移植　57　(総会臨時)　347-347　2022/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  325. 皮下膵島移植における低酸素環境改善のための新規組織内酸素濃度測定法の開発

    三頭 啓明, 猪村 武弘, 稲垣 明子, 遠藤 有希子, 片野 匠, 齋藤 竜助, 宮城 重人, 渡邉 君子, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　57　(総会臨時)　312-312　2022/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  326. 膵・膵島移植の適応についての再考 膵・膵島移植新時代における適応判定・ドナー選択の東北大新基準

    戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 宮崎 勇希, 山名 浩樹, 宮城 重人, 和田 基, 海野 倫明, 亀井 尚, 後藤 昌史

    移植　57　(総会臨時)　206-206　2022/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  327. 膵臓移植手術手技-私たちの工夫- 東北大学における膵臓移植手術手技 課題とこれからの展望

    松村 宗幸, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 宮城 重人, 海野 倫明, 亀井 尚

    移植　57　(総会臨時)　208-208　2022/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  328. 抗菌薬/消毒薬の局所使用による感染の予防と治療 在宅中心静脈栄養症例におけるカテーテルエタノールロックによる感染予防および抗菌剤ロックによる治療効果

    渡辺 和宏, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科感染症学会雑誌　19　(1)　204-204　2022/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  329. 腸管不全症の治療-現状と未来- 成人腸管不全例の現状と長期的に安全な管理への取り組み

    渡辺 和宏, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S103-S103　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  330. 壁外浸潤大腸がんの治療 当院におけるT4b大腸癌の治療成績と臓器機能温存に向けた取り組み

    梶原 大輝, 小野 智之, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S151-S151　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  331. GISTの治療 直腸GISTに術前化学療法

    小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S161-S161　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  332. 定型化した双孔式回腸人工肛門の造設手技

    唐澤 秀明, 小野 智之, 小林 実, 梶原 大輔, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S248-S248　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  333. 直腸切断術後に前立腺癌由来の転移性直腸腫瘍の診断に至った1例

    名久井 佑子, 神山 篤史, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 渡辺 和宏, 大沼 忍, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S265-S265　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  334. 膵癌術前GS療法施行症例におけるABO血液型と予後との関係

    水間 正道, 青木 修一, 伊関 雅裕, 井上 亨悦, 中山 瞬, 三浦 孝之, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 粂 潔, 正宗 淳, 海野 倫明

    日本消化器外科学会雑誌　55　(Suppl.2)　265-265　2022/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  335. 【胆嚢疾患診療の最前線】胆嚢癌の疫学

    中川 圭, 伊関 雅裕, 青木 修一, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 海野 倫明

    肝胆膵　85　(4)　475-480　2022/10

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  336. 【最先端の画像支援技術を用いた肝胆膵外科手術】肝門部領域胆管癌の術前シミュレーションにおける3D画像解析の有用性

    青木 修一, 中川 圭, 伊関 雅裕, 森川 孝則, 海野 倫明

    手術　76　(11)　1707-1713　2022/10

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  337. ロボット・内視鏡時代の術中トラブルシューティング 腹腔鏡下DSTにおけるトラブルシューティング

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 土屋 堯裕, 井本 博文, 山村 明寛, 田中 直樹, 西條 文人, 森川 孝則, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S200-S200　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  338. 局所進行胃GISTに対する術前化学療法の有用性の検討

    添田 敏寛, 土屋 尭裕, 田中 直樹, 山村 明寛, 井本 博文, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S522-S522　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  339. 胆道閉鎖症生体肝移植術後4年にレシピエント組織由来の胆管癌腹膜播種を生じた一例

    佐々木 健吾, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 宮崎 勇希, 松村 宗幸, 石川 裕貴, 藤島 史喜, 吉野 裕顕, 東海林 琢男, 海野 倫明, 亀井 尚

    移植　57　(総会臨時)　390-390　2022/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  340. 食道癌に対するロボット支援下手術の治療成績 ロボット支援下食道切除術の現状と今後への展望

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 小澤 洋平, 石田 裕嵩, 小関 健, 山内 拓郎, 加藤 伸文, 大沼 忍, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　83　(増刊)　S118-S118　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  341. 集中治療における早期栄養療法開始の実践 食道癌術後におけるICUからの早期経腸栄養の実際と注意点

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 石田 裕嵩, 小関 健, 山内 拓郎, 加藤 伸史, 大沼 忍, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　83　(増刊)　S186-S186　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  342. 当科における80歳以上の食道癌患者に対する手術戦略と成績

    加藤 伸史, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 石田 裕嵩, 小関 健, 山内 拓郎, 大沼 忍, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　83　(増刊)　S242-S242　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  343. 消化器癌手術における術後感染症が癌予後に与える影響の多施設共同調査 胆道癌

    伊関 雅裕, 水間 正道, 海野 倫明, 丸山 弘, 上村 健一郎, 小林 美奈子, 松田 明久, 渡邉 学, 塩見 尚礼, 下田 貢, 種本 和雄, 北川 雄光

    日本外科感染症学会雑誌　19　(1)　236-236　2022/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  344. 【術前画像の読み解きガイド—的確な術式選択と解剖把握のために】 Frey手術

    堂地 大輔, 水間 正道, 石田 晶玄, 日下 彬子, 青木 修一, 井上 亨悦, 伊関 雅裕, 中山 瞬, 三浦 孝之, 有明 恭平, 高舘 達之, 大塚 英郎, 中川 圭, 森川 孝則, 海野 倫明

    臨床外科　77　(11)　163-167　2022/10

    Publisher: 株式会社医学書院

    DOI： 10.11477/mf.1407213903 　

    ISSN： 0386-9857

    eISSN： 1882-1278

  345. 十二指腸乳頭部癌術後10年以上経過後に発症した膵管内転移の1例

    赤森 洋太, 伊関 雅裕, 國米 崇, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 水間 正道, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 古川 徹, 海野 倫明

    日本臨床外科学会雑誌　83　(増刊)　S314-S314　2022/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  346. 膵癌術前GS療法施行症例におけるABO血液型と予後との関係

    水間 正道, 青木 修一, 伊関 雅裕, 井上 亨悦, 中山 瞬, 三浦 孝之, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 粂 潔, 正宗 淳, 海野 倫明

    日本消化器外科学会雑誌　55　(Suppl.2)　265-265　2022/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  347. A case of refractory esophageal stricture due to occult gastrinoma of the duodenum.

    Keisuke Kusano, Kaname Uno, Tomoyuki Koike, Shin Miura, Kiyoshi Kume, Masato Nakahori, Fumiyoshi Fujishima, Hideo Ohtsuka, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　15　(5)　859-863　2022/10

    DOI： 10.1007/s12328-022-01657-x 　

    More details Close

    Gastrinoma may cause refractory esophageal stricture due to gastro-esophageal reflux disease (GERD), but imaging technologies have limited power in its diagnosis. A 74-year-old female with a history of peptic ulcers suffered from repeated epigastralgia, and she visited a local hospital. An esophago-gastro-duodenoscopy (EGD) demonstrated severe reflux esophagitis and multiple peptic ulcers. Blood examination revealed a high value of fasting serum gastrin. Multi-detector computed tomography showed a hypervascular and tiny nodule in duodenal bulb, although other imaging technologies did not. Short-term medication with a proton pump inhibitor or potassium-competitive acid blocker was intermittently provided, but dysphagia was repeatedly worsened, and she was referred to our division. Serum hypergastrinemia was retained, and EGD reexamination depicted esophageal stricture, treated by multiple sessions of endoscopic balloon dilatation. Primary tumor was not identified by the morphological imaging technologies, but a selective arterial secretagogue injection test suggested its existence in the duodenum or pancreatic head. Pancreaticoduodenectomy was performed, and histological study identified 2 mm-sized microgastrinoma buried in Brunner`s glands on the posterior wall of the duodenum bulb. We reported a case with difficulty in diagnosis of the smallest sporadic gastrinoma of the duodenum, which might cause refractory GERD-associated stricture.

  348. Pathological Evaluation of Resected Colorectal Liver Metastases: mFOLFOX6 Plus Bevacizumab versus mFOLFOX6 Plus Cetuximab in the Phase II ATOM Trial. International-journal

    Takao Takahashi, Kazuyuki Ishida, Yasunori Emi, Michiie Sakamoto, Johji Imura, Shinichi Aishima, Kei Muro, Hiroyuki Uetake, Eiji Oki, Yu Katayose, Kazuhiro Yoshida, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Kenichi Sugihara, Yoshihiko Maehara

    Cancers　14　(18)　2022/09/09

    DOI： 10.3390/cancers14184392 　

    More details Close

    We compared the preplanned histopathological responses of resected liver metastases from patients who received modified FOLFOX6 plus bevacizumab or modified FOLFOX6 plus cetuximab for liver-limited colorectal metastases in the ATOM trial. Fibrosis and viable tumor cells in tumor regression grade (TRG), infarct-like necrosis in modified TRG (mTRG), and dangerous halo (DH) were assessed. Fifty-five patients (28 and 27 patients in the bevacizumab and cetuximab arms, respectively) were divided into the low (viable tumor cells ≤ 50%) and high (>50%) TRG or mTRG groups. DH was characterized as absent/rare or focal/diffuse. Compared to the bevacizumab arm, the cetuximab arm was more effective, with respect to low TRG (13 vs. 23 patients) and absent/rare DH (14 vs. 19 patients), respectively. Low mTRG was similarly observed in both arms. Low TRG/mTRG and absent/rare DH showed better relapse-free survival (RFS) than high TRG/mTRG and focal/diffuse DH. In the bevacizumab arm, a significant difference in RFS existed between the low and high TRG groups, while in the cetuximab arm, for TRG, mTRG, and DH, the low and absent/rare groups demonstrated significantly longer RFS than the high and focal/diffuse groups, respectively. TRG could estimate RFS in patients who underwent liver metastasectomy after bevacizumab or cetuximab chemotherapy.

  349. 患者由来がんオルガノイドの増殖と粘液分泌の特徴からみたIPMNの浸潤性表現型の立証(Characteristics of growth and mucus secretion of patient-derived organoids may substantiate invasive phenotypes of IPMN)

    Shiihara Masahiro, Ishikawa Tomohiko, Yoshida Takuya, Omori Yuko, Hirose Katsuya, Morikawa Takanori, Nakagawa Kei, Mizuma Masamichi, Otsuka Hideo, Motoi Fuyuhiko, Unno Michiaki, Okamura Yasunobu, Kinoshita Kengo, Furukawa Toru

    膵臓　37　(3)　A391-A392　2022/09

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  350. 男女を問わず外科医が輝き続けるために 持続可能社会における外科医の働き方 男女ともに輝き続けるために必要なこと

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 金井 哲史, 西牧 宏泰, 亀井 尚, 海野 倫明

    日本外科学会雑誌　123　(5)　489-491　2022/09

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  351. 【炎症性腸疾患治療における外科と内科の接点】Crohn病に対する腸管切除後のフォローアップと治療

    渡辺 和宏, 大沼 忍, 神山 篤史, 唐澤 秀明, 亀井 尚, 海野 倫明

    外科　84　(10)　1044-1048　2022/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  352. 【IBD術後の諸問題に対応する!】潰瘍性大腸炎術後の重篤な小腸炎

    神山 篤史, 福島 浩平, 渡辺 和宏, 大沼 忍, 海野 倫明

    IBD Research　16　(3)　143-148　2022/09

    Publisher: (株)先端医学社

    ISSN： 1881-6533

  353. 術前診断を得て内科治療を先行したCrohn病による回腸尿膜管瘻の1切除例

    丸山 大貴, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　42　(6)　691-694　2022/09

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  354. クローン病の内科的治療と外科的治療 クローン病の短腸症候群の発症予防,適切な管理法のための当科での取り組み

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 大沼 忍, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　75　(9)　A35-A35　2022/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  355. 大腸癌合併潰瘍性大腸炎の治療戦略

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　75　(9)　A176-A176　2022/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  356. 当科におけるT1大腸癌の治療成績と内視鏡治療後追加切除の意義

    梶原 大輝, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 小林 実, 小野 智之, 大沼 忍, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　75　(9)　A192-A192　2022/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  357. 当科における肝門部胆管癌に対するConversion surgeryの現状と課題

    青木 修一, 中川 圭, 海野 倫明, 伊関 雅裕, 井上 亨悦, 大塚 英郎, 水間 正道, 森川 孝則, 粂 潔, 正宗 淳

    胆道　36　(3)　366-366　2022/09

    Publisher: (一社)日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  358. RUNX3の点変異体RUNX3 R122Cは、胃のisthmus幹細胞の自己複製能を亢進かつ分化能を阻害し、前癌状態を形成する(A point mutation RUNX3 R122C promotes the expansion of isthmus stem cells and inhibits their differentiation in stomach)

    堂地 大輔, 山村 明寛, 松尾 純一, 志村 充広, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明, 伊藤 嘉明

    日本癌学会総会記事　81回　J-1035　2022/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  359. STK11が変化した膵管内乳頭粘液性腫瘍は特有の臨床病理学的特徴を示す(STK11-aletered intraductal papillary mucinous neoplasms develop characteristic clinico-patho-biology)

    Omori Yuko, Ono Yusuke, Itoh Taito, Date Fumiko, Morikawa Takanori, Motoi Fuyuhiko, Higuchi Ryota, Honda Goro, Karasaki Hidenori, Mizukami Yusuke, Unno Michiaki, Furukawa Toru

    膵臓　37　(3)　A391-A391　2022/09

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  360. PRKACA/Bの再配列と発現が膵胆管好酸性腫瘍の表現型を規定する(Rearrangement and expression of PRKACA/B governs phenotypes of pancreato-biliary oncocytic neoplasms)

    Itoh Taito, Omori Yuko, Seino Mitsuru, Hirose Katsuya, Date Fumiko, Ono Yusuke, Mizukami Yusuke, Mizuma Masamichi, Morikawa Takanori, Higuchi Ryota, Honda Goro, Unno Michiaki, Furukawa Toru

    膵臓　37　(3)　A392-A393　2022/09

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  361. 膵癌取扱い規約第7版の再評価-局所進展度因子とresectability別治療成績- 膵癌患者における腹腔洗浄細胞診(CY)の再評価

    里井 壯平, 藤井 努, 平林 健一, 大池 信之, 谷 眞至, 眞杉 洋平, 上野 誠, 中井 陽介, 橋本 大輔, 石田 晶玄, 海野 倫明, 竹山 宜典, 膵癌取り扱い規約委員会CYサブグループ

    膵臓　37　(3)　A287-A287　2022/09

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  362. Expression of corticotropin-releasing hormone and its receptors may be associated with survival rate in pancreatic cancer

    Naoko Sato, Fuyuhiko Motoi, Hana Tajiki, Kei Kawaguchi, Hideo Ohtsuka, Tatuyuki Takadate, Kei Nakagawa, Kiyoshi Takagi, Takashi Suzuki, Yu Katayose, Shin Fukudo, Michiaki Unno

    Gastro Hep Advances　2022/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.gastha.2022.09.003 　

    ISSN： 2772-5723

  363. Development of a novel method for measuring tissue oxygen pressure to improve the hypoxic condition in subcutaneous islet transplantation

    Hiroaki Mitsugashira, Takehiro Imura, Akiko Inagaki, Yukiko Endo, Takumi Katano, Ryusuke Saito, Shigehito Miyagi, Kimiko Watanabe, Takashi Kamei, Michiaki Unno, Masafumi Goto

    Scientific Reports　12　(1)　2022/08/30

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-19189-2 　

    eISSN： 2045-2322

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    Abstract Subcutaneous tissue is a promising site for islet transplantation, but poor engraftment, due to hypoxia and low vascularity, hinders its prevalence. However, oxygen partial pressure (pO2) of the subcutaneous space (SC) and other sites were reported to be equivalent in several previous reports. This contradiction may be based on accidental puncture to the indwelling micro-vessels in target tissues. We therefore developed a novel optical sensor system, instead of a conventional Clark-type needle probe, for measuring tissue pO2 and found that pO2 of the SC was extremely low in comparison to other sites. To verify the utility of this method, we transplanted syngeneic rat islets subcutaneously into diabetic recipients under several oxygenation conditions using an oxygen delivery device, then performed pO2 measurement, glucose tolerance, and immunohistochemistry. The optical sensor system was validated by correlating the pO2 values with the transplanted islet function. Interestingly, this novel technique revealed that islet viability estimated by ATP/DNA assay reduced to less than 75% by hypoxic condition at the SC, indicating that islet engraftment may substantially improve if the pO2 levels reach those of the renal subcapsular space. Further refinements for a hypoxic condition using the present technique may contribute to improving the efficiency of subcutaneous islet transplantation.

  364. Disease-related protein co-expression networks are associated with the prognosis of resectable node-positive pancreatic ductal adenocarcinoma. International-journal

    Toshihide Nishimura, Tatsuyuki Takadate, Shimpei Maeda, Takashi Suzuki, Takashi Minowa, Tetsuya Fukuda, Yasuhiko Bando, Michiaki Unno

    Scientific reports　12　(1)　14709-14709　2022/08/29

    DOI： 10.1038/s41598-022-19182-9 　

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    Pancreatic ductal adenocarcinoma (PDAC) is a multifactorial disease, the molecular profile of which remains unclear. This study aimed at unveiling the disease-related protein networks associated with different outcomes of resectable, node-positive PDAC cases. We assessed laser-microdissected cancerous cells from PDAC tissues of a poor outcome group (POG; n = 4) and a better outcome group (BOG; n = 4). Noncancerous pancreatic duct tissues (n = 5) were used as the reference. We identified four representative network modules by applying a weighted network correlation analysis to the obtained quantitative PDAC proteome datasets. Two network modules that were significant for POG were associated with the heat shock response to hypoxia-related stress; in the latter, a large involvement of the non-canonical Hedgehog pathway (regulated by GLI1), the internal ribosome entry site-mediated cap-independent translation, the inositol requiring enzyme 1-alpha (IRE1α)/X-box binding protein 1 pathway of the unfolding protein response (UPR), and the aerobic glycolysis was observed. By contrast, the BOG characteristic module was involved in the inactivation of the UPR pathway via the synoviolin 1-dependent proteasomal degradation of IRE1α, the activation of SOX2, and the loss of PALB2 (partner and localizer of BRCA2) function, all potentially suppressing malignant tumor development. Our findings might facilitate future therapeutic strategies for PDAC.

  365. Comparison of acute gastrointestinal toxicities between 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy including prophylactic regions in chemoradiotherapy with S-1 for pancreatic cancer-importance of dose volume histogram parameters in the stomach as the predictive factors. International-journal

    Rei Umezawa, Kei Nakagawa, Masamichi Mizuma, Yoshiyuki Katsuta, Shohei Tanaka, Noriyuki Kadoya, Yu Suzuki, Kazuya Takeda, Noriyoshi Takahashi, Takaya Yamamoto, Michiaki Unno, Keiichi Jingu

    Journal of radiation research　63　(6)　856-865　2022/08/20

    DOI： 10.1093/jrr/rrac049 　

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    The purpose of this study was to compare acute gastrointestinal (GI) toxicities in patients who underwent 3-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) in chemoradiotherapy (CRT) with S-1 including prophylactic regions for pancreatic cancer. We also investigated the predictive factor of acute GI toxicities in dose volume histogram (DVH) parameters. Patients who received CRT with S-1 for pancreatic cancer between January 2014 and March 2021 were included. Radiotherapy (RT) with a total dose of 50-54 Gy was delivered. We examined the differences in the frequencies of acute GI toxicity of grade 2 or higher and DVH parameters of the stomach (ST) and duodenum (DU) between the 3DCRT group and the IMRT group. The RT-related predictive factors of acute GI toxicities were investigated by univariate and multivariate analyses. There were 25 patients in the 3DCRT group and 31 patients in the IMRT group. The frequencies of acute GI toxicity of G2 or higher were 36% in the 3DCRT group and 9.7% in the IMRT group (p = 0.035). ST V50 was the most predictive factor (p = 0.001), and the incidences of acute GI toxicity of G2 or higher in ST V50 ≥ 4.1 cc and < 4.1cc were 43.7% and 7.7%, respectively. ST V40 was also a significant predictive factor of acute GI toxicity (p = 0.002). IMRT could reduce acute GI toxicities in CRT with S-1 including prophylactic regions for pancreatic cancer. Acute GI toxicities may be affected by moderate to high doses to the ST.

  366. A case of intestinal malrotation apparent after laparoscopically total proctocolectomy followed by ileal-pouch-anal anastomosis for ulcerative colitis.

    Hidetaka Ichikawa, Shinobu Ohnuma, Hirofumi Imoto, Sakiko Kageyama, Minoru Kobayashi, Taiki Kajiwara, Hideaki Karasawa, Atsushi Kohyama, Kazuhiro Watanabe, Naoki Tanaka, Takashi Kamei, Michiaki Unno

    Asian journal of endoscopic surgery　2022/08/11

    DOI： 10.1111/ases.13114 　

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    Intestinal malrotation (IM) is an abnormality due to a failure of the normal midgut rotation and fixation. We report a case of 46-year-old man with ulcerative colitis whose IM was apparent after laparoscopically total proctocolectomy (TPC) followed by ileal-pouch-anal anastomosis (IPAA) and ileostomy. There was no abnormal anatomy except for mobile cecum/ascending colon during the initial operation. Intestinal obstruction occurred after ileostomy closure. The computed tomography scan showed the duodeno-jejunal transition was located in right abdomen, the superior mesenteric vein was located left of the superior mesenteric artery (SMA) and the obstruction point was the distal ileum near the pouch. We performed an ileo-ileo bypass across the ventral side of the SMA to relieve the intestinal obstruction. The patient would have incomplete IM preoperatively, which became apparent by TPC. In case of TPC for mobile colon, anatomy of small intestine should be checked before IPAA.

  367. 直腸切除後の排便排尿および性機能障害に対するスマート問診システムの確立と機能障害評価

    梶原 大輝, 大沼 忍, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　47　(4)　611-611　2022/08

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  368. Pancreatic mixed acinar-neuroendocrine carcinoma in a patient with a germline BRCA2 mutation: a case report.

    Mio Ikeda, Shin Miura, Kiyoshi Kume, Kazuhiro Kikuta, Shin Hamada, Tetsuya Takikawa, Kei Nakagawa, Michiaki Unno, Toru Furukawa, Atsushi Masamune

    Clinical journal of gastroenterology　15　(5)　999-1005　2022/07/12

    DOI： 10.1007/s12328-022-01668-8 　

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    Loss of function in the BRCA2 gene exacerbates ovarian, breast, and pancreatic ductal cancer risk. Despite being implicated in the pancreatic ductal epithelium carcinogenesis, the involvement of a germline BRCA2 mutation in acinar and endocrine cells is less reported. A 45-year-old woman with a history of breast cancer was referred to our hospital for a detailed examination of epigastric pain. Her father had pancreatic cancer, and her paternal aunt had a history of breast cancer. Contrast-enhanced computed tomography revealed a round tumor with a contrast effect in the pancreatic head. The patient underwent pancreaticoduodenectomy, and postoperative pathology and genetic testing revealed amphicrine-type mixed acinar-neuroendocrine carcinoma with a germline BRCA2 mutation. Recent studies have reported the BRCA2 mutation in genome sequencing of pancreatic acinar cell carcinoma and neuroendocrine tumor; perhaps, genetic testing for the BRCA2 mutation is feasible for patients with mixed neuroendocrine-non-neuroendocrine neoplasm.

  369. A New Strategy of Liver Transplantation for Locally Advanced Unresectable Perihilar Cholangiocarcinoma Using Living Grafts With Simultaneous Resection of Recipients' Hepatic Artery and Portal Vein Without Neoadjuvant Radiation: A Case Report. International-journal

    Shigehito Miyagi, Atsushi Fujio, Kei Nakagawa, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroyasu Nishimaki, Taizo Hibi, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　2022/07/06

    DOI： 10.1016/j.transproceed.2022.03.054 　

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    BACKGROUND: Perihilar cholangiocarcinoma (pCCA) is often unresectable, because it includes crucial blood vessels in portal area. The prognosis of locally advanced unresectable cholangiocarcinomas is extremely poor. Recently, there have been several reports of the prognosis improving drastically with transplantation and combined chemoradiation therapy. However, liver transplantation for pCCA has 2 big problems. The first is that pCCA is located at a lethal position and its progress is sometimes rapid; therefore, the optimal timing of transplantation is sometimes lost. The second is vascular complications associated with neoadjuvant radiation, especially in living donor liver transplantation (LDLT). To overcome these problems, we performed conversion surgery using LDLT with simultaneous resection of the hepatic artery and portal vein, instead of neoadjuvant radiation. Herein, we report our experience of interposition reconstruction. METHODS: A 31-year-old man with primary sclerosing cholangitis (PSC) was diagnosed with locally advanced unresectable pCCA. The patient underwent radical chemotherapy (gemcitabine/cisplatin/S-1) and avoided radiation because of PSC. After 6 months, positron emission tomography-computed tomography revealed no lymph node metastasis. There was no time to wait. We immediately performed LDLT with simultaneous resection of hepatic artery and portal vein, and microsurgical reconstruction using auto-vessel grafts. RESULTS: The recipient recovered and was discharged 31 days posttransplant. His liver function improved, and he has had no recurrence after LDLT. CONCLUSION: LDLT with neoadjuvant radiation is associated with high risk of vascular complications. In some cases, conversion surgery after radical chemotherapy using good timing LDLT without radiation may increase chances of transplantation for locally advanced pCCA.

  370. Use of Perfluorohexyloctane for Preservation of Rat Liver After Circulatory Death and a Prolonged Cold Preservation Model for Hepatocyte Transplantation

    Muneyuki Matsumura, Takehiro Imura, Akiko Inagaki, Hiroyuki Ogasawara, Shigehito Miyagi, Kazuo Ohashi, Michiaki Unno, Takashi Kamei, Masafumi Goto

    Transplant International　35　2022/07/05

    Publisher: Frontiers Media SA

    DOI： 10.3389/ti.2022.10659 　

    eISSN： 1432-2277

  371. ヒト羊膜由来細胞を用いた細胞移植治療法確立に向けて

    戸子台 和哲, 田中 美也子, 岡田 薫, 星合 哲郎, 齋藤 昌利, 海野 倫明, 三木 敏生, 亀井 尚, 後藤 昌史

    Organ Biology　29　(2)　124-127　2022/07

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  372. 【総論】各臓器サブサブスペシャルティ外科医の育成法 東北大学における移植外科医育成プログラムの構築 肝膵腎小腸摘出チームにおける取り組み

    宮澤 恒持, 宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　WS15-8　2022/07

    Publisher: (一社)日本消化器外科学会

  373. 血管合併症を有する高難度肝移植における手術手技の工夫 浅大腿静脈グラフトを用いた血行再建法について

    戸子台 和哲, 宮崎 勇希, 松村 宗幸, 佐々木 健吾, 宮澤 恒持, 柏舘 俊明, 藤尾 淳, 宮城 重人, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　77回　P013-3　2022/07

    Publisher: (一社)日本消化器外科学会

  374. Co-axial port settingによる右側結腸癌に対する腹腔鏡下右結腸切除術

    大沼 忍, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　P060-3　2022/07

    Publisher: (一社)日本消化器外科学会

  375. 切除不能遠隔転移を伴う原発巣非切除大腸癌に対する化学療法中の緩和手術施行例の検討

    市川 英孝, 大沼 忍, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　P082-5　2022/07

    Publisher: (一社)日本消化器外科学会

  376. クローン病の腸管吻合、および、萎縮細径腸管のストーマ閉鎖におけるSasaki-Watanabe吻合の手技(続報)

    渡辺 和宏, 神山 篤史, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　77回　RSV4-3　2022/07

    Publisher: (一社)日本消化器外科学会

  377. 根治切除を行った80歳以上の高齢者大腸癌の短期成績の評価と予後予測因子についての検討

    梶原 大輝, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　P151-4　2022/07

    Publisher: (一社)日本消化器外科学会

  378. 【下部】IBDに対するMIS クローン病に対する開腹回盲部切除術と腹腔鏡下回盲部切除術の比較・検討

    小林 実, 渡辺 和宏, 市川 英孝, 梶原 大輝, 唐澤 秀明, 神山 篤史, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　WS14-7　2022/07

    Publisher: (一社)日本消化器外科学会

  379. 局所進行S状結腸癌に対する術前化学療法の短期成績

    唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　77回　RS18-5　2022/07

    Publisher: (一社)日本消化器外科学会

  380. クローン病の膿瘍形成・穿孔症例に対する当科での外科治療

    齋藤 達, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　78-78　2022/07

    Publisher: 日本消化器病学会-東北支部

  381. SEMS留置により円滑な情報提供と治療方針の決定が可能となった高齢認知症患者の閉塞性S状結腸癌の1例

    佐藤 将大, 梶原 大輝, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 小林 実, 小野 智之, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　80-80　2022/07

    Publisher: 日本消化器病学会-東北支部

  382. Laparoscopic and robot-assisted surgery for adult congenital biliary dilatation achieves favorable short-term outcomes without increasing the risk of late complications.

    Takanori Morikawa, Hideo Ohtsuka, Tatsuyuki Takadate, Masaharu Ishida, Takayuki Miura, Masamichi Mizuma, Kei Nakagawa, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　52　(7)　1039-1047　2022/07

    DOI： 10.1007/s00595-021-02438-8 　

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    PURPOSE: Minimally invasive surgery (MIS) is the optimal treatment for congenital biliary dilatation (CBD), but few studies on adults have been reported. We compared the postoperative outcomes of MIS with those of open surgery (OS) in adult patients with CBD. METHODS: The subjects of this retrospective study were 36 adult patients who underwent surgery for CBD. We compared the postoperative outcomes of 20 patients who underwent laparoscopic (n = 15) or robotic (n = 5) surgery with those of 16 patients who underwent OS. RESULTS: MIS was associated with a significantly higher rate of type I (p < 0.001), significantly less blood loss (p < 0.001), a significantly lower rate of internal stents (p = 0.048), significantly longer operation times (p = 0.009), and a significantly shorter postoperative hospital stay (p = 0.007) than OS. The postoperative outcomes of MIS for type I CBD were similar to those of the whole cohort. There were no significant differences in late complications between the groups. The robotic procedure had a significantly shorter operative time than laparoscopic surgery for hepaticojejunostomy (HJ; p = 0.029). CONCLUSIONS: MIS achieved favorable short-term outcomes without compromising mid-term outcomes compared to OS and is appropriate for adult patients with CBD. Robotic HJ may be more ideal than its laparoscopic counterpart.

  383. Levels of tumor markers CEA/CA 19-9 in serum and peritoneal lavage predict postoperative recurrence in patients with pancreatic cancer Peer-reviewed

    Tatsuo Hata, Kazuharu Chiba, Masamichi Mizuma, Kunihiro Masuda, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Michiaki Unno

    Annals of Gastroenterological Surgery　6　(6)　862-872　2022/07

    DOI： 10.1002/ags3.12597 　

  384. 脳死肺移植後の末期腎不全に対し、移植後11年で生体腎移植を施行したリンパ脈管筋腫症の1例

    齋藤 純健, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 太田 嶺人, 宇根 範和, 金井 哲史, 渡辺 有為, 秋葉 美紀, 宮城 重人, 岡田 克典, 海野 倫明, 亀井 尚

    日本臨床腎移植学会雑誌　10　(1)　91-95　2022/07

    Publisher: (一社)日本臨床腎移植学会

    ISSN： 2187-9907

  385. 内科と外科の協働治療 WONに対する当科の内視鏡治療の現状と外科治療移行例の検討

    粂 潔, 三浦 晋, 滝川 哲也, 海野 倫明, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　213回　57-57　2022/07

    Publisher: 日本消化器病学会-東北支部

  386. ヒト羊膜由来細胞を用いた細胞移植治療法確立に向けて

    戸子台 和哲, 田中 美也子, 岡田 薫, 星合 哲郎, 齋藤 昌利, 海野 倫明, 三木 敏生, 亀井 尚, 後藤 昌史

    Organ Biology　29　(2)　124-127　2022/07

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  387. クローン病の膿瘍形成・穿孔症例に対する当科での外科治療

    齋藤 達, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 小野 智之, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　78-78　2022/07

    Publisher: 日本消化器病学会-東北支部

  388. SEMS留置により円滑な情報提供と治療方針の決定が可能となった高齢認知症患者の閉塞性S状結腸癌の1例

    佐藤 将大, 梶原 大輝, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 小林 実, 小野 智之, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　80-80　2022/07

    Publisher: 日本消化器病学会-東北支部

  389. Risk factors associated with hypoglycemic events after total pancreatectomy: A nationwide multicenter prospective study in Japan

    Hironobu Suto, Keiko Kamei, Hiroyuki Kato, Takeyuki Misawa, Michiaki Unno, Hiroyuki Nitta, Sohei Satoi, Yasunari Kawabata, Masayuki Ohtsuka, Toshiki Rikiyama, Takeshi Sudo, Ippei Matsumoto, Tomohiro Hirao, Keiichi Okano, Yasuyuki Suzuki, Naohiro Sata, Shuji Isaji, Masanori Sugiyama, Yoshifumi Takeyama

    Surgery　2022/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.surg.2022.04.031 　

    ISSN： 0039-6060

  390. Pancreaticoduodenectomy for pancreatic head cancer with cavernous transformation of the portal vein: a case report. International-journal

    Naohiro Hirano, Masahiro Iseki, Takanori Morikawa, Yuuichiro Umino, Shuichi Aoki, Koetsu Inoue, Shun Nakayama, Takayuki Miura, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Kiyoshi Kume, Atsushi Masamune, Takashi Kamei, Michiaki Unno

    Surgical case reports　8　(1)　127-127　2022/06/30

    DOI： 10.1186/s40792-022-01463-0 　

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    BACKGROUND: Cavernous transformation of the portal vein (CTPV) due to extrahepatic portal vein obstruction is a rare vascular anomaly. Since its symptoms usually appear in childhood, most of the adult cases are detected unexpectedly with other diseases. Only a few reports have described surgical difficulties in patients with CTPV. We report a case of pancreatic head cancer with CTPV in a patient who underwent pancreaticoduodenectomy. CASE PRESENTATION: A 77-year-old man with epigastric and back pain was referred to our hospital. Computed tomography revealed a tumor in the pancreatic head and a CTPV near the hepatic hilum. CTPV consisted of two main collateral vessels connected by multiple surrounding small vessels. Also, portal vein obstruction was observed near the hepatic hilum, which was far from the pancreatic head tumor. After confirming that there was no distant metastasis by a thorough whole-body search, we performed a pancreaticoduodenectomy following neoadjuvant chemotherapy. During the operation, we carefully manipulated the area of the CTPV and omitted lymph node dissection in the hepatoduodenal ligament to prevent massive venous bleeding and intestinal congestion. Pancreaticoduodenectomy was performed without any intraoperative complications and the postoperative course was uneventful. Complete tumor resection was histologically confirmed. CONCLUSION: Although pancreaticoduodenectomy for patients with CTPV involves many surgical difficulties, we successfully performed it by determining specific treatment strategies tailored to the patient and following careful and delicate surgical procedures.

  391. Comparison of infectious complications after spleen preservation versus splenectomy during laparoscopic distal pancreatectomy for benign or low-grade malignant pancreatic tumors: A multicenter, propensity score-matched analysis.

    Woohyung Lee, Dae Wook Hwang, Ho-Seong Han, In Woong Han, Jin Seok Heo, Michiaki Unno, Masaharu Ishida, Hiroshi Tajima, Nobuyuki Nishizawa, Kohei Nakata, Yasuji Seyama, Yoshiya Isikawa, Ho Kyoung Hwang, Jin-Young Jang, Taeho Hong, Joon Seong Park, Hee Joon Kim, Chi-Young Jeong, Ippei Matsumoto, Hiroki Yamaue, Manabu Kawai, Masayuki Ohtsuka, Shugo Mizuno, Mitsuhiro Asakuma, Yuji Soejima, Teijiro Hirashita, Masayuki Sho, Yutaka Takeda, Jeong-Ik Park, Yong Hoon Kim, Hwa Jung Kim, Hiroki Yamaue, Masakazu Yamamoto, Itaru Endo, Masafumi Nakamura, Yoo-Seok Yoon

    Journal of hepato-biliary-pancreatic sciences　30　(2)　252-262　2022/06/29

    DOI： 10.1002/jhbp.1213 　

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    BACKGROUND: Previous studies have reported contrasting results regarding the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. METHODS: A total of 3787 patients who underwent LDP for benign or low-grade malignant pancreatic disease in 92 centers across Korea and Japan were included in this retrospective study. Postoperative infectious complications and other complications were compared between LDP with splenectomy (LDPS) and LDP with spleen preservation (LSPDP) by propensity score matching (PSM) analysis. RESULTS: After PSM, the LSPDP group had a lower rate of overall infectious complications (P = .079) and a significantly lower rate of intra-abdominal abscess (P = .014) compared with the LDPS group. Within the LSPDP group, the vessel preservation subgroup had a significantly higher rate of infectious complications (P = .002) compared with the vessel resection subgroup. Low-volume centers had a higher rate of intra-abdominal abscess than high-volume centers in the LSPDP group (P = .001) and the splenic vessel preservation subgroup (P = .003). CONCLUSIONS: Spleen preservation in LDP for benign or borderline malignant pancreatic diseases was advantageous in lowering the risk of infectious complications, specifically intra-abdominal abscess. However, the risk of intra-abdominal abscess may differ according to the level of surgeon's experience.

  392. 【炎症性腸疾患の治療戦略と手術】クローン病 クローン病に対する腹腔鏡(補助下)手術

    渡辺 和宏, 大沼 忍, 神山 篤史, 唐澤 秀明, 亀井 尚, 海野 倫明

    手術　76　(7)　1079-1083　2022/06

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  393. A randomized controlled trial of surgery and postoperative modified FOLFOX6 versus surgery and perioperative modified FOLFOX6 plus cetuximab in patients with KRAS wild-type resectable colorectal liver metastases: EXPERT study. International-journal

    Masaru Matsumura, Kiyoshi Hasegawa, Masaru Oba, Kensei Yamaguchi, Hiroyuki Uetake, Takayuki Yoshino, Satoshi Morita, Keiichi Takahashi, Michiaki Unno, Yasuhiro Shimada, Kei Muro, Nobuhisa Matsuhashi, Masaki Mori, Hideo Baba, Mitsuo Shimada, Yoshihiro Mise, Yoshikuni Kawaguchi, Tatsuo Kagimura, Kiyoshi Ishigure, Akio Saiura, Kenichi Sugihara, Norihiro Kokudo

    Langenbeck's archives of surgery　407　(4)　1345-1356　2022/06

    DOI： 10.1007/s00423-022-02434-7 　

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    PURPOSE: To clarify the efficacy of perioperative chemotherapy for the patients with resectable colorectal liver metastases (CLM), we conducted a multicenter randomized phase III trial to compare surgery followed by postoperative FOLFOX regimen with perioperative FOLFOX regimen plus cetuximab in patients with KRAS wild-type resectable CLM. METHODS: Patients who had KRAS wild-type resectable CLM having one to eight liver nodules without extrahepatic disease were randomly assigned to the postoperative chemotherapy group, wherein up-front hepatectomy was performed followed by 12 cycles of postoperative modified FOLFOX6, and the perioperative chemotherapy group (experimental), wherein six cycles of preoperative modified FOLFOX6 plus cetuximab were performed followed by hepatectomy and six cycles of postoperative modified FOLFOX6 plus cetuximab. The primary endpoint was progression-free survival (PFS). RESULTS: There were 37 patients in postoperative chemotherapy group and 40 patients in the perioperative chemotherapy group who were analyzed. Baseline characteristics were well-balanced between groups. The PFS and overall survival (OS) showed no significant difference (PFS, hazard ratio 1.18 [95% confidence interval 0.69-2.01], P = 0.539: OS, 1.03 [0.46-2.29], P = 0.950). In the postoperative chemotherapy group, 35.1% had a 3-year PFS, and 86.5% had a 3-year OS. Meanwhile, in the perioperative chemotherapy group, 30.0% had a 3-year PFS, and 74.4% had a 3-year OS. CONCLUSION: There was no difference in survival found between the group of the perioperative chemotherapy plus cetuximab and that of the postoperative chemotherapy in the cohort of our study. The study was registered in the University Hospital Medical Information Network (UMIN000007787).

  394. Correction to: Clinical guidelines for primary sclerosing cholangitis 2017.

    Hiroyuki Isayama, Susumu Tazuma, Norihiro Kokudo, Atsushi Tanaka, Toshio Tsuyuguchi, Takahiro Nakazawa, Kenji Notohara, Suguru Mizuno, Nobuhisa Akamatsu, Masahiro Serikawa, Itaru Naitoh, Yoshiki Hirooka, Toshifumi Wakai, Takao Itoi, Tomoki Ebata, Shinji Okaniwa, Terumi Kamisawa, Hiroki Kawashima, Atsushi Kanno, Keiichi Kubota, Masami Tabata, Michiaki Unno, Hajime Takikawa

    Journal of gastroenterology　57　(6)　453-454　2022/06

    DOI： 10.1007/s00535-022-01867-7 　

  395. Perioperative Administration of Cystine and Theanine Suppresses Inflammation and Facilitates Early Rehabilitation and Recovery after Esophagectomy: A Randomized, Double-Blind, Controlled Clinical Trial. International-journal

    Hiroshi Okamoto, Yusuke Taniyama, Tadashi Sakurai, Gaku Kodama, Chiaki Sato, Toshiaki Fukutomi, Yohei Ozawa, Hirotaka Ishida, Ken Koseki, Takuro Yamauchi, Toru Nakano, Michiaki Unno, Takashi Kamei

    Nutrients　14　(11)　2022/05/31

    DOI： 10.3390/nu14112319 　

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    Oral administration of cystine and theanine (CT) increases glutathione levels to modulate the inflammatory response, which has yet to be sufficiently explored for patients' recovery and early rehabilitation. We planned a randomized, double-blind, placebo-controlled trial to determine whether perioperative oral administration of CT promotes recovery after esophagectomy. Patients were randomized into either CT or placebo groups, who received preoperative and postoperative treatments for 4 and 13 days, respectively. The main outcome measures were triaxial accelerometer readings, inflammation indicators, a 6 min walk test (6MWT), and a quality of life questionnaire (QoR-40). The study involved 32 patients. Although the CT group (n = 16) showed better patient activity across the investigated period, there was no significant difference between the two groups. However, white blood cell count on postoperative days (POD) 2 and 10, neutrophil count (POD 2, 7, and 10), and C-reactive protein level (POD 13) in the CT group were significantly lower than in the placebo group. Furthermore, 6MWT on POD 7 and QoR-40 on POD 13 were significantly higher in the CT group than those in the placebo group. This study suggests that perioperative administration of CT may contribute to early recovery and rehabilitation after esophagectomy via suppression of inflammatory response.

  396. A nationwide certification system to increase the safety of highly advanced hepatobiliary-pancreatic surgery.

    Takehito Otsubo, Shinjiro Kobayashi, Keiji Sano, Takeyuki Misawa, Satoshi Katagiri, Hisashi Nakayama, Shuji Suzuki, Manabu Watanabe, Shunichi Ariizumi, Michiaki Unno, Minoru Tanabe, Hiroaki Nagano, Norihiro Kokudo, Satoshi Hirano, Masafumi Nakamura, Ken Shirabe, Yasuyuki Suzuki, Masahiro Yoshida, Yasutsugu Takada, Toshio Nakagohri, Akihiko Horiguchi, Hideki Ohdan, Susumu Eguchi, Masayuki Ohtsuka, Masayuki Sho, Toshiki Rikiyama, Etsuro Hatano, Akinobu Taketomi, Tsutomu Fujii, Hiroki Yamaue, Masaru Miyazaki, Masakazu Yamamoto, Tadahiro Takada, Itaru Endo

    Journal of hepato-biliary-pancreatic sciences　30　(1)　60-71　2022/05/24

    DOI： 10.1002/jhbp.1186 　

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    BACKGROUND: To ensure that highly advanced hepatobiliary-pancreatic surgery (HBPS) is performed safely, the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) board certification system for expert surgeons established a safety committee to monitor surgical safety. METHODS: We investigated postoperative mortality rates based on summary reports of numbers and outcomes of highly advanced HBPS submitted annually by the board-certified training institutions from 2012 to 2019. We also analyzed summary reports on mortality cases submitted by institutions with high 90-day post-HBPS mortality rates and recommended site visits and surveys as necessary. RESULTS: Highly advanced HBPS was performed in 121,518 patients during the 8-year period. Thirty-day mortality rates from 2012 to 2019 were 0.92%, 0.8%, 0.61%, 0.63%, 0.70%, 0.59%, 0.48%, and 0.52%, respectively (p < .001). Ninety-day mortality rates were 2.1%, 1.82%, 1.62%, 1.28%, 1.46%, 1.22%, 1.19%, and 0.98%, respectively (p < .001). Summary reports were submitted by 20 hospitals between 2015 and 2019. Mortality rates before and after the start of report submission and audit were 5.72% and 2.79%, respectively, (odds ratio 0.690, 95% confidence interval 0.487-0.977; p = .037). CONCLUSIONS: Development of a system for designation of board-certified expert surgeons and safety management improved the mortality rate associated with highly advanced HBPS.

  397. Prospective clinical study for claudication after endovascular aneurysm repair involving hypogastric artery embolization.

    Shunya Suzuki, Daijirou Akamatsu, Hitoshi Goto, Takaaki Kakihana, Hirofumi Sugawara, Ken Tsuchida, Yoshitaro Yoshida, Michihisa Umetsu, Takashi Kamei, Michiaki Unno

    Surgery today　2022/05/09

    DOI： 10.1007/s00595-022-02502-x 　

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    PURPOSE: This prospective study aimed to assess the prognosis of claudication after endovascular aneurysm repair (EVAR) involving hypogastric artery (HGA) embolization. METHODS: Patients who were scheduled to undergo EVAR involving bilateral or unilateral HGA embolization (BHE or UHE, respectively) between May 2017 and January 2019 were included in this study. Patients underwent the walk test preoperatively, one week postoperatively, and monthly thereafter for six months. The presence of claudication and the maximum walking distance (MWD) were recorded. A near-infrared spectroscopy monitor was placed on the buttocks, and the recovery time (RT) was determined. A walking impairment questionnaire (WIQ) was completed to determine subjective symptoms. RESULTS: Of the 13 patients who completed the protocol, 12 experienced claudication in the 6-min walk test. The MWD was significantly lower at one week postoperatively than preoperatively. The claudication prevalence was significantly higher at five and six months postoperatively after BHE than after UHE. BHE was associated with longer RTs and lower WIQ scores than UHE. CONCLUSIONS: We noted a trend in adverse effects on the gluteal circulation and subjective symptoms ameliorating within six months postoperatively, with more effects being associated with BHE than with UHE. These findings should be used to make decisions concerning management strategies for HGA reconstruction.

  398. Long-term survival of an adult patient with undifferentiated embryonal sarcoma of the liver with multidisciplinary treatment: a case report and literature review. International-journal

    Yukiko Kumata Endo, Atsushi Fujio, Keigo Murakami, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Kazuaki Tokodai, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    Surgical case reports　8　(1)　85-85　2022/05/05

    DOI： 10.1186/s40792-022-01436-3 　

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    BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) primarily occurs in children; it is rarely seen in adults and appears to have a poor prognosis. However, in recent years, some cases indicated that long-term survival was possible due to a combination of multiple surgeries, chemotherapy, and liver transplantation. CASE PRESENTATION: A 33-year-old female patient presented with a complaint of epigastric pain, for which she underwent a medical examination. Computed tomography (CT) and magnetic resonance imaging showed a cystic tumor in the right hepatic lobe, approximately 10 cm in size. During observation, the abdominal pain worsened, and a contrast-enhanced CT revealed that the tumor's peripheral solid components increased in size and volume, suggesting a malignant tumor threatening hepatic rupture. Subsequently, transcatheter arterial embolization of the anterior and posterior segmental branches of the hepatic artery was performed, followed by right trisectionectomy. Histopathological and immunohistochemical examinations of the lesion revealed UESL. Two months after the surgery, we initiated sarcoma-directed chemotherapy with doxorubicin because of multiple metastases to the liver. After initiating the chemotherapy, she received another regimen using gemcitabine/docetaxel, eribulin, trabectedin, ifosfamide/mesna, pazopanib, and cisplatin. During the chemotherapy, she underwent palliative surgery twice due to the progressive disease. She lived for 49 months after the initial operation. CONCLUSIONS: Improved long-term survival was achieved in an adult patient with UESL after multidisciplinary therapy, involving a combination of three surgical procedures and several chemotherapies.

  399. 術前放射線化学療法の進歩 局所進行下部直腸癌に対する術前化学放射線療法の治療成績

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　47　(3)　300-300　2022/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  400. 術前放射線化学療法の進歩 局所進行下部直腸癌に対する術前化学放射線療法の治療成績

    大沼 忍, 小野 智之, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　47　(3)　300-300　2022/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  401. Modified Socratic Method (planned and executed by Takada) for medical education: Grade II Acute Cholecystitis of Tokyo Guidelines 2018 as an example case.

    Tadahiro Takada, Shuji Isaji, Masahiro Yoshida, Akihiko Horiguchi, Hisami Ando, Shuichi Miyakawa, Seiki Kiriyama, Harumi Gomi, Shuntaro Mukai, Ryota Higuchi, Yuta Abe, Kohji Okamoto, Kenji Suzuki, Naoyuki Toyota, Shutaro Hori, Yuki Homma, Hiroyuki Kato, Akiko Umezawa, Jiro Hata, Dai Inoue, Motoyuki Kobayashi, Toshio Tsuyuguchi, Hirotoshi Maruo, Yusuke Kumamoto, Yukio Asano, Yuka Kondo, Satoshi Arakawa, Koji Asai, Yasuhisa Mori, Yukiko Nagamachi, Shugo Mizuno, Shintaro Yagi, Tetsuji Ohyama, Takeyuki Misawa, Keiji Sano, Takao Itoi, Nobuhiko Taniai, Michiaki Unno, Masakazu Yamamoto, Toshihiko Mayumi

    Journal of hepato-biliary-pancreatic sciences　29　(5)　505-520　2022/05

    DOI： 10.1002/jhbp.1076 　

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    BACKGROUND: Socratic method, which is an educational method to promote critical thinking through a dialogue, has never been practiced in a large number of people at the academic societies. METHODS: Modified Socratic method was performed for the first time as an educational seminar using an example case of moderate acute cholecystitis based on the evidence described in Tokyo Guidelines 2018. We adopted a method that Takada had been modifying for many years: the instructor first knows the degree of recognition of the audience, then the instructor gives a lecture in an easy-to-understand manner and receives questions from the audience, followed by repeated questions and answers toward a common recognition. RESULTS: Using slides, video, and an answer pad, 281 participants including the audience, instructors and moderators came together to repeatedly ask and answer questions in the five sessions related to the case scenario. The recognition rate of the topic of Critical View of Safety increased significantly before vs after this method (53.0% vs 90.3%). The seminar had been successfully performed by receiving a lot of praise from the participants. CONCLUSION: This educational method is considered to be adopted by many academic societies in the future as an effective educational method.

  402. Steroid therapy still plays a crucial role and could serve as a bridge to the next promising treatments in patients with IgG4-related sclerosing cholangitis: Results of a Japanese Nationwide Study.

    Kensuke Kubota, Terumi Kamisawa, Takahiro Nakazawa, Atsushi Tanaka, Itaru Naitoh, Hajime Takikawa, Michiaki Unno, Shigeyuki Kawa, Atsushi Masamune, Seiji Nakamura, Kazuichi Okazaki

    Journal of hepato-biliary-pancreatic sciences　2022/04/22

    DOI： 10.1002/jhbp.1157 　

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    OBJECTIVE: The acceptable duration of steroid therapy for patients with IgG4-sclerosing cholangitis (SC) has been under debate. Our aim is to clarify the feasible duration of steroid treatment. DESIGN: We retrospectively reviewed the data of patients with IgG4-SC and analyzed the following: biliary status during the steroid therapy, incidence of remission, relapse, relapse-free survival rate, and steroid-related complications (SRCs). RESULTS: Remission was achieved 99.5% (763/767) of patients who received steroid therapy, while remission rate dropped to 63.6% (78/129) of patients who didn't receive it. Relapse was noted in 19.7% (151/763) of the patients who received steroid. Besides, relapse rate went up 38.4% (30/78) of the counterpart. Normalization of the serum total bilirubin and serum alkaline phosphatase (ALP) levels were achieved at two weeks regardless of biliary drainage. Multivariate analysis identified younger onset, MST less than three years, immunosuppressant, and steroid cessation as independent risk factors for relapse. Steroid-free was achieved in the patients underwent MST only 3.4% over 54 months. SRCs were recorded in a total of 99 patients (12.9%) despite sufficient preemptive medications. Multivariate analysis identified history of malignancy and immunosuppressant as independent risk factors for SRCs. CONCLUSION: Steroid therapy should be continued for no less than three years to reduce the risk of relapse, with use of preemptive measures taken around five years. The biliary drainage might not be mandatory. Steroid as 1st line therapy could serve as a bridge to further promising treatments.

  403. Cotransplantation With Adipose Tissue-Derived Stem Cells Improves Engraftment of Transplanted Hepatocytes. International-journal

    Hiroki Yamana, Akiko Inagaki, Takehiro Imura, Yasuhiro Nakamura, Hiroyasu Nishimaki, Takumi Katano, Kazuo Ohashi, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Masafumi Goto

    Transplantation　106　(10)　1963-1973　2022/04/11

    DOI： 10.1097/TP.0000000000004130 　

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    BACKGROUND: Hepatocyte transplantation is expected to be an alternative therapy to liver transplantation; however, poor engraftment is a severe obstacle to be overcome. The adipose tissue-derived stem cells (ADSCs) are known to improve engraftment of transplanted pancreatic islets, which have many similarities to the hepatocytes. Therefore, we examined the effects and underlying mechanisms of ADSC cotransplantation on hepatocyte engraftment. METHODS: Hepatocytes and ADSCs were cotransplanted into the renal subcapsular space and livers of syngeneic analbuminemic rats, and the serum albumin level was quantified to evaluate engraftment. Immunohistochemical staining and fluorescent staining to trace transplanted cells in the liver were also performed. To investigate the mechanisms, cocultured supernatants were analyzed by a multiplex assay and inhibition test using neutralizing antibodies for target factors. RESULTS: Hepatocyte engraftment at both transplant sites was significantly improved by ADSC cotransplantation (P < 0.001, P < 0.001). In the renal subcapsular model, close proximity between hepatocytes and ADSCs was necessary to exert this effect. Unexpectedly, ≈50% of transplanted hepatocytes were attached by ADSCs in the liver. In an in vitro study, the hepatocyte function was significantly improved by ADSC coculture supernatant (P < 0.001). The multiplex assay and inhibition test demonstrated that hepatocyte growth factor, vascular endothelial growth factor, and interleukin-6 may be key factors for the abovementioned effects of ADSCs. CONCLUSIONS: The present study revealed that ADSC cotransplantation can improve the engraftment of transplanted hepatocytes. This effect may be based on crucial factors, such as hepatocyte growth factor, vascular endothelial growth factor, and interleukin-6, which are secreted by ADSCs.

  404. 直腸癌局所再発の診断・治療の現状 直腸癌局所再発に対する治療の現状 手術成績とR0切除後再々発症例の検討

    大沼 忍, 唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 山村 明寛, 田中 直樹, 内藤 覚, 齋藤 達, 佐藤 将大, 西條 文人, 森川 孝則, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　WS-2　2022/04

    Publisher: (一社)日本外科学会

  405. 炎症性腸疾患に対する外科治療 クローン病の腸管切除例におけるSasaki-W吻合と従来吻合の周術期成績の検討

    渡辺 和宏, 神山 篤史, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　WS-8　2022/04

    Publisher: (一社)日本外科学会

  406. 術前化学放射線治療後の直腸低位前方切除術にdiverting stoma造設を併施する意義

    市川 英孝, 神山 篤史, 小林 実, 梶原 大輝, 唐澤 秀明, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　SF-3　2022/04

    Publisher: (一社)日本外科学会

  407. 腹腔鏡下低位前方切除術後の縫合不全ならびに予防的diverting stomaが医療費に与える影響

    小林 実, 市川 英孝, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　SF-5　2022/04

    Publisher: (一社)日本外科学会

  408. 下部進行直腸癌における側方リンパ節転移と再発の関係からみた側方郭清の意義

    梶原 大輝, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　SF-2　2022/04

    Publisher: (一社)日本外科学会

  409. 大腸癌切除検体を用いたトランスレーショナル研究 癌関連線維芽細胞とオルガノイド

    唐澤 秀明, 相澤 卓, 平嶋 倫亮, 田山 穂高, 市川 英孝, 小林 実, 梶原 大輝, 山村 明寛, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　SF-5　2022/04

    Publisher: (一社)日本外科学会

  410. 潰瘍性大腸炎手術における「高齢者」の定義を検討する

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　DP-1　2022/04

    Publisher: (一社)日本外科学会

  411. 持続可能社会における外科医の働き方 男女ともに輝き続けるために必要なこと

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 金井 哲史, 西牧 宏泰, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　SP-2　2022/04

    Publisher: (一社)日本外科学会

  412. 米国での移植外科クリニカルフェローを経験して

    松村 宗幸, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 金井 哲史, 西牧 宏泰, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　FS-5　2022/04

    Publisher: (一社)日本外科学会

  413. 胆道閉鎖症患者における移植機会喪失の可能性とその回避方法

    佐々木 健吾, 西牧 宏泰, 宮崎 勇希, 松村 宗幸, 宮澤 恒持, 柏館 俊明, 藤尾 淳, 戸子台 和哲, 宮城 重人, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　SF-2　2022/04

    Publisher: (一社)日本外科学会

  414. 手術侵襲が肝細胞癌に対する初回肝切除の予後に与える影響の検討

    西牧 宏泰, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　DP-6　2022/04

    Publisher: (一社)日本外科学会

  415. 当院における肝線維化F4症例に対する腹腔鏡下肝切除の検討

    宮澤 恒持, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 佐々木 健吾, 松村 宗幸, 金井 哲史, 西牧 宏泰, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　122回　DP-4　2022/04

    Publisher: (一社)日本外科学会

  416. 巨大悪性褐色細胞腫に対しハイブリット室にて栄養血管塞栓後に腫瘍摘出術を行った一例

    飯塚 友理子, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 宮城 重人, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　RS-8　2022/04

    Publisher: (一社)日本外科学会

  417. 術後3年経過し異時性副腎転移として出現した転移性肺癌の一例

    菊地 貴大, 西牧 宏泰, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　RS-9　2022/04

    Publisher: (一社)日本外科学会

  418. がん抑制遺伝子RUNX3の点変異体RUNX3(R122C)は、胃の上皮幹細胞の増殖を促進し、その分化を阻害する

    堂地 大輔, 山村 明寛, 松尾 純一, Lee Jung-Won, 志村 充広, 森川 孝則, 大沼 忍, Bae Suk-Chul, 亀井 尚, 石田 孝宣, 海野 倫明, 伊藤 嘉明

    日本外科学会定期学術集会抄録集　122回　SF-3　2022/04

    Publisher: (一社)日本外科学会

  419. 大動脈気管支瘻腸管瘻に対する治療 一期的開腹手術による二次性腹部大動脈腸管瘻(sAEF)に対する治療成績

    赤松 大二朗, 後藤 均, 橋本 宗敬, 芹澤 玄人, 田島 悠太, 梅津 道久, 堀井 晋一良, 高橋 宏和, 小笠原 紀信, 長岡 洋平, 清水 港太, 木村 俊作, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　WS-4　2022/04

    Publisher: (一社)日本外科学会

  420. ラット極小肝移植モデルへのMuse細胞の静脈投与が及ぼすHGF/VEGFAによる肝類洞保護効果について

    菖野 佳浩, 串田 良祐, 若尾 昌平, 黒田 康勝, 海野 倫明, 亀井 尚, 宮城 重人, 出澤 真理

    日本外科学会定期学術集会抄録集　122回　SF-2　2022/04

    Publisher: (一社)日本外科学会

  421. 肝胆膵領域における再生医療研究の最前線 羊膜由来幹細胞を用いた肝・膵機能不全に対する細胞移植治療法の確立

    戸子台 和哲, 田中 美也子, 佐藤 将人, 岡田 薫, 星合 哲郎, 齋藤 昌利, 宮城 重人, 三木 敏生, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　WS-5　2022/04

    Publisher: (一社)日本外科学会

  422. ヒト羊膜のラット虚血性潰瘍モデルにおける創傷治癒効果と血管新生促進効果の検討

    佐藤 将人, 戸子台 和哲, 菅原 宏文, 今野 裕司, 田中 美也子, 岡田 薫, 小笠原 弘之, 齋藤 昌利, 星合 哲郎, 宮城 重人, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　SF-3　2022/04

    Publisher: (一社)日本外科学会

  423. ゲノム・遺伝子情報を用いて乳癌診療の未来を拓く【International】組織及び血漿ベースでのがん遺伝子パネル検査による乳癌ゲノム医療の現状と今後の課題

    多田 寛, 宮下 穣, 原田 成美, 濱中 洋平, 江幡 明子, 本成 登喜和, 金井 綾子, 小坂 真吉, 進藤 晴彦, 角掛 聡子, 今野 美歌, 大沼 忍, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　122回　SY-2　2022/04

    Publisher: (一社)日本外科学会

  424. 内分泌療法耐性乳癌におけるL型アミノ酸トランスポーター1(LAT1)を介した代謝変化の新規標的の可能性

    進藤 晴彦, 原田 成美, 多田 寛, 宮下 穣, 濱中 洋平, 江幡 明子, 金井 綾子, 小坂 真吉, 柳垣 美歌, 角掛 聡子, 本成 登貴和, 鈴木 貴, 大沼 忍, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　122回　DP-6　2022/04

    Publisher: (一社)日本外科学会

  425. トリプルネガティブ乳癌組織における性ホルモン濃度の検討

    江幡 明子, 三木 康宏, 高木 清司, 岩渕 英里奈, 多田 寛, 原田 成美, 濱中 洋平, 宮下 穣, 佐藤 章子, 深町 佳世子, 金井 綾子, 柳垣 美歌, 進藤 晴彦, 角掛 聡子, 本成 登貴和, 大沼 忍, 亀井 尚, 海野 倫明, 鈴木 貴, 石田 孝宣

    日本外科学会定期学術集会抄録集　122回　DP-8　2022/04

    Publisher: (一社)日本外科学会

  426. A potential preventive method for scar stenosis after esophageal endoscopic mucosal resection using human amniotic epithelial cells in a porcine model. International-journal

    Yuji Konno, Chiaki Sato, Kazuaki Tokodai, Masatoshi Saito, Tetsuro Hoshiai, Yusuke Taniyama, Hiroshi Okamoto, Toshiaki Fukutomi, Yohei Ozawa, Naoto Ujiie, Ken Koseki, Ryohei Ando, Kozue Takahashi, Yasuharu Shinozaki, Michiaki Unno, Takashi Kamei

    DEN open　2　(1)　e104　2022/04

    DOI： 10.1002/deo2.104 　

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    Objectives: The current methods employed for esophageal endoscopic mucosal resection (EMR) involve the risk of adverse postprocedural complications. Therefore, this study aimed to develop a new method to prevent stenosis following a resection procedure using human amniotic epithelial cells in a porcine model. Methods: With the consent of a woman who underwent a cesarean section, amniotic epithelial cells were isolated from the amniotic membrane of the delivered placenta. Six swine were used for this study. Under general anesthesia, four EMRs using cap-fitted microscope ulcers were performed on each porcine esophagus. Of the four ulcers, the two on the oral side were treated by injecting human amniotic epithelial (AE group) cells, and the remaining two on the anal side were left untreated (control group). One week after the procedure, the swine were sacrificed, and the ulcers were evaluated. The epithelialization rate was calculated by dividing the length of the epithelialized portion of each section by the length of the ulcer, which was determined using an optical microscope. Moreover, the mucosal thickening in each section was measured in terms of diameter. Results: The epithelialization rate was significantly higher in the AE group than in the control group. Mucosal thickening was not significantly different between the groups. Conclusions: Transplanting amniotic epithelial cells into the ulcer promoted ulcer epithelialization. Amniotic epithelial cell transplantation is a potential method for the management of ulcer scar stenosis following esophageal endoscopic submucosal dissection.

  427. 大動脈気管支瘻腸管瘻に対する治療 一期的開腹手術による二次性腹部大動脈腸管瘻(sAEF)に対する治療成績

    赤松 大二朗, 後藤 均, 橋本 宗敬, 芹澤 玄人, 田島 悠太, 梅津 道久, 堀井 晋一良, 高橋 宏和, 小笠原 紀信, 長岡 洋平, 清水 港太, 木村 俊作, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　WS-4　2022/04

    Publisher: (一社)日本外科学会

  428. Clinical features and prognostic impact of asymptomatic pancreatic cancer. International-journal

    Tetsuya Takikawa, Kazuhiro Kikuta, Shin Hamada, Kiyoshi Kume, Shin Miura, Naoki Yoshida, Yu Tanaka, Ryotaro Matsumoto, Mio Ikeda, Fumiya Kataoka, Akira Sasaki, Kei Nakagawa, Michiaki Unno, Atsushi Masamune

    Scientific reports　12　(1)　4262-4262　2022/03/11

    DOI： 10.1038/s41598-022-08083-6 　

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    Pancreatic ductal adenocarcinoma (PDAC) is highly lethal, and early diagnosis is challenging. Because patients who present with symptoms generally have advanced-stage diseases, analysis of asymptomatic PDAC provides invaluable information for developing strategies for early diagnosis. Here, we reviewed 577 patients with PDAC (372 diagnosed with symptoms [symptomatic group] and 205 without symptoms [asymptomatic group]) diagnosed at our institute. Among the 205 asymptomatic PDAC patients, 109 were detected during follow-up/work-up for other diseases, 61 because of new-onset or exacerbation of diabetes mellitus, and 35 in a medical check-up. Asymptomatic PDAC is characterized by smaller tumor size, earlier disease stage, and higher resectability than those of symptomatic PDAC. In 22.7% of asymptomatic cases, indirect findings, e.g., dilatation of the main pancreatic duct, triggered PDAC detection. Although pancreatic tumors were less frequently detected, overall abnormality detection rates on imaging studies were nearly 100% in asymptomatic PDAC. Asymptomatic PDAC had a better prognosis (median survival time, 881 days) than symptomatic PDAC (342 days, P < 0.001). In conclusion, diagnosis of PDAC in the asymptomatic stage is associated with early diagnosis and a better prognosis. Incidental detection of abnormal findings during the follow-up/work-up for other diseases provides important opportunities for early diagnosis of asymptomatic PDAC.

  429. Short-term inhalation of isoflurane improves the outcomes of intraportal hepatocyte transplantation. International-journal

    Hiroyasu Nishimaki, Yoshikatsu Saitoh, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Ibrahim Fathi, Hiroki Yamana, Kazuo Ohashi, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Masafumi Goto

    Scientific reports　12　(1)　4241-4241　2022/03/10

    DOI： 10.1038/s41598-022-08237-6 　

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    Clinical hepatocyte transplantation (HTx) is only performed without general anesthesia, while inhalation anesthetics are usually used in animal experiments. We hypothesized that isoflurane may be a possible reason for the discrepancy between the results of animal experiments and the clinical outcomes of HTx. Syngeneic rat hepatocytes (1.0 × 107) were transplanted to analbuminemic rats with (ISO group) and without (AW group) isoflurane. The serum albumin, AST, ALT, LDH levels and several inflammatory mediators were analyzed. Immunohistochemical staining and ex vivo imaging were also performed. The serum albumin levels of the ISO group were significantly higher in comparison to the AW group (p < 0.05). The serum AST, ALT, LDH levels of the ISO group were significantly suppressed in comparison to the AW group (p < 0.0001, respectively). The serum IL-1β, IL-10, IL-18, MCP-1, RNTES, Fractalkine and LIX levels were significantly suppressed in the ISO group. The ischemic regions of the recipient livers in the ISO group tended to be smaller than the AW group; however, the distribution of transplanted hepatocytes in the liver parenchyma was comparable between the two groups. Isoflurane may at least in part be a reason for the discrepancy between the results of animal experiments and the clinical outcomes of HTx.

  430. 肥満症における腸管の意義 腸内環境から探る十二指腸空腸バイパス術の代謝改善効果

    土屋 尭裕, 田中 直樹, 井本 博文, 山村 明寛, 杉沢 徳彦, 市川 英孝, 佐々木 啓迪, 川名 友美, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　148-148　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  431. 混合組織型早期胃癌のリンパ節転移リスクの検討(Risk of lymph node metastasis in mixed-type histology in early gastric cancer)

    川名 友美, 山村 明寛, 田中 直樹, 井本 博文, 杉沢 徳彦, 土屋 堯裕, 山崎 有人, 佐々木 啓迪, 西條 文人, 大沼 忍, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　94回　271-271　2022/03

    Publisher: (一社)日本胃癌学会

  432. 膵胆道腫瘍におけるPRKACA,PRKACB融合遺伝子の意義

    伊藤 泰斗, 大森 優子, 青野 光, 廣瀬 勝也, 水間 正道, 森川 孝則, 海野 倫明, 樋口 亮太, 本田 五郎, 古川 徹

    日本病理学会会誌　111　(1)　238-238　2022/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  433. 高度肥満症に対する特色あるチームアプローチ(心理・栄養・看護・理学療法の立場から) 高度肥満症に対する理学療法士の役割 東北大学病院における取り組みの実際

    新國 悦弘, 小丹 晋一, 辻村 淳, 竹内 雅史, 原田 卓, 田中 直樹, 井本 博文, 海野 倫明, 上月 正博

    肥満研究　27　(Suppl.)　241-241　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  434. 術前化学療法後の膵癌におけるGATA6、CK5免疫組織化学によるフェノタイプ評価は再発予測因子となる

    國米 崇, 大森 優子, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 正宗 淳, 海野 倫明, 古川 徹

    日本病理学会会誌　111　(1)　238-238　2022/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  435. 膵胆道腫瘍におけるPRKACA,PRKACB融合遺伝子の意義

    伊藤 泰斗, 大森 優子, 青野 光, 廣瀬 勝也, 水間 正道, 森川 孝則, 海野 倫明, 樋口 亮太, 本田 五郎, 古川 徹

    日本病理学会会誌　111　(1)　238-238　2022/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  436. Oxygenated Hypothermic Machine Perfusion of Kidney Transplantation from Donors After Cardiac Death Due to Long-Term Low Blood Pressure and Hypoxia: The First Case Report of a Clinical Trial Using a New Japanese Perfusion System. International-journal

    Shigehito Miyagi, Toshiaki Kashiwadate, Hiroyasu Nishimaki, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuku Matsumura, Michiaki Unno, Takashi Kamei, Naoto Matsuno

    Transplantation proceedings　54　(2)　225-229　2022/03

    DOI： 10.1016/j.transproceed.2021.09.075 　

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    BACKGROUND: Machine perfusion of marginal kidney grafts obtained from donors after cardiac death (DCD) has become a standard therapy worldwide. However, the use of grafts from DCD due to long-term low blood pressure is associated with a high incidence of primary graft nonfunction. Furthermore, the importance of oxygenation in machine perfusion remains unclear. We report the first case of a clinical trial of a kidney transplant obtained from a DCD using a Japanese oxygenated hypothermic perfusion system (CMX-08W, Chuo Seiko Co Ltd, Asahikawa, Japan). PATIENTS AND METHODS: The donor was a 61-year-old man with amyotrophic lateral sclerosis. His SpO2 decreased to 80% to 90%, his blood pressure remained consistently low for 4 hours and 30 minutes, and he suffered a cardiac arrest. Subsequently, we carried him to the operating room. The warm ischemic time was 12 minutes, and the cold ischemic time was 418 minutes. The recipient was a 58-year-old man who had been undergoing hemodialysis for 26 years. He was diagnosed with nephrosclerosis and multiple renal cysts. Oxygenated hypothermic machine perfusion was used on the kidney transplant obtained from the DCD. RESULTS: The recipient gradually recovered and was withdrawn from hemodialysis therapy 14 days post transplantation. His renal function improved, and he was discharged on postoperative day 36. Currently, his renal function remains good (phosphocreatine, 1.7). CONCLUSIONS: Oxygenated machine perfusion is used to preserve organs and determine if an organ is suitable for transplantation. This may provide the possibility of perfusion preservation and expand the criteria for cardiac arrest-associated renal transplantation.

  437. Usefulness of Thiel-Embalmed Cadavers for Training in Organ Procurement. International-journal

    Hiroaki Mitsugashira, Kazuaki Tokodai, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Shigehito Miyagi, Yuji Owada, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　54　(2)　230-232　2022/03

    DOI： 10.1016/j.transproceed.2021.10.026 　

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    BACKGROUND: The number of brain-dead donors has been increasing; however, the opportunity for young surgeons to experience deceased donor surgeries is extremely limited, especially in many Asian countries including Japan. Deceased donor surgeries require unique surgical skills and knowledge; however, it is difficult to provide on-the-job guidance and education. Therefore, cadaver training is meaningful and suitable for the training of deceased donor surgeries. Thiel's embalming method (TEM) provides natural coloration, flexibility, and tissue plasticity, and is widely used for cadaver surgical training. In this study, we evaluated the usefulness of Thiel's embalmed cadaver training for organ procurement surgery. MATERIAL AND METHODS: Each trainee performed hepatectomy, pancreatectomy, and nephrectomy using conventional open techniques. Faculty experts of transplantation surgery and organ procurement took attendees through surgical steps. After the procedure, all participants were asked to complete a voluntary, anonymous survey, consisting of a 10-point satisfaction scale, to evaluate their perceptions of the training. RESULTS: A total of 33 gastrointestinal surgeons participated in the training program for procuring the liver, pancreas, and kidneys. In the questionnaire administered to the participants, the evaluation was generally satisfactory, with an average of 9.1 points on the 10-point scales. Some participants expressed that Thiel-embalmed cadavers are more suitable for training on organ procurement compared with animals used in wet-lab training. CONCLUSION: We conclude that organ procurement training in human cadavers preserved by TEM is useful and suitable for practicing deceased donor organ procurement, especially in countries where deceased donors are not common, as in Japan.

  438. Adult Living Donor Liver Transplantation for the Carryover Patients After Kasai Operation Who Have a History of Multiple Laparotomies. International-journal

    Shigehito Miyagi, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　54　(2)　430-434　2022/03

    DOI： 10.1016/j.transproceed.2021.09.073 　

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    OBJECTIVE: Approximately 50 years have passed since the Kasai operation announcement for biliary atresia. In adult liver failure cases, the so-called "the carryover cases after Kasai operation" have increased. These patients often underwent polysurgery. In such cases, adult living-donor liver transplantation (LDLT) is occasionally difficult. Many complications have been reported to be caused by severe cholangitis, hepatic portal regional inflammation, and adhesion. We investigated the complications of adult LDLT in post-Kasai biliary atresia cases with polysurgery. METHODS: Between 1991 and 2021, we performed 205 LDLT cases. We investigated the outcome of adult LDLT for post-Kasai biliary atresia cases (transplanted over 16 years old) (n = 20) and the risk factors for complications after LDLT. RESULTS: On 5 years overall survival, there were no significant differences between "adult LDLT for post-Kasai" group and the others (81.8% vs 81.2%). Adult LDLT for post-Kasai was not found to be a risk factor for complications. However, polysurgery before LDLT was an independent risk factor for biliary stenosis and portal stenosis, as identified in our univariate and multivariate analysis. We analyzed the relationship between biliary stenosis and the frequency of laparotomies using a receiver operating characteristic curve. The analysis showed that the cutoff point (maximum point of sensitivity plus specificity) was more than 3 times that of laparotomies before LDLT. CONCLUSIONS: In our study, adult LDLT for post-Kasai cases was not a risk factor for any complications. However, polysurgery before LDLT has been identified as a risk factor for biliary stenosis and portal vein stenosis.

  439. Optimal Conditions for Oxygenated Subnormothermic Machine Perfusion for Liver Grafts Using a Novel Perfusion Device. International-journal

    Hiroyasu Nishimaki, Shigehito Miyagi, Toshiaki Kashiwadate, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Takashi Kamei, Michiaki Unno

    Transplantation proceedings　54　(2)　217-224　2022/03

    DOI： 10.1016/j.transproceed.2021.12.025 　

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    BACKGROUND: Liver transplantation from donors after cardiac death (DCD) resolves donor shortages. PURPOSE: We investigated the optimal time for subnormothermic oxygenated perfusion in DCD liver transplantation. METHODS: Ten F1 pigs (body weight: 27-32 kg) were allocated to 2 groups: the heart beating group (n = 6), from which livers were retrieved while the heart was beating, and the donation after cardiac death (DCD) group (n = 4), in which liver retrieval was performed on pigs under apnea-induced cardiac arrest for 20 minutes. In both groups, the livers were kept in cold storage for 2 hours after retrieval and perfused with a subnormothermic oxygenated Krebs-Henseleit buffer for 120 minutes. We used a novel perfusion device, which can set maximum perfusion pressures of arteries and portal vein, developed by Asahikawa Medical University and Chuo Seiko Co. Bile production, liver enzymes, and inflammatory cytokines were measured and the sinusoidal space, using tissue specimens taken from liver grafts, was measured at 30, 60, 90, and 120 minutes after the start of perfusion. RESULTS: Bile production peaked at 90 minutes. Significantly higher levels of liver enzymes and inflammatory cytokines were found in the DCD group (P < .05). The release of liver enzymes peaked at 60 minutes and that of inflammatory cytokines peaked at 90 minutes. The hepatic sinusoidal space was wide at 90 minutes and narrowed after 120 minutes. CONCLUSIONS: The results suggest that subnormothermic oxygenation perfusion may maintain optimal graft condition until around 90 minutes and perfusion for more than 120 minutes may be counterproductive.

  440. Cholesterol Granuloma of the Liver Mimicking Malignant Tumor: A Case Report.

    Yuki Ishikawa, Atsushi Fujio, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Yoshikatsu Saitoh, Mio Tsuruoka, Jun Inoue, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　256　(3)　235-240　2022/03

    DOI： 10.1620/tjem.256.235 　

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    Cholesterol granuloma is a benign, tumor-like lesion with an accumulation of cholesterol crystals in the tissue and is a consequence of a chronic inflammatory reaction. It commonly occurs in the middle ear but rarely in the liver. There is only one previous case report of cholesterol granuloma of the liver, which was caused by cholesterol hepatolithiasis. We report a case of cholesterol granuloma of the liver in a patient with no intrahepatic cholesterol stones; it was difficult to rule out malignant liver tumor preoperatively. The patient was a 79-year-old woman in whom a lesion in the liver was detected on abdominal ultrasonography. She was referred to our hospital for detailed examination and treatment. Abdominal contrast-enhanced computed tomography showed a 20 mm lesion with ring enhancement in the lateral segment of the liver during the arterial and delayed phases. Since a malignant tumor could not be ruled out radiologically, laparoscopic lateral segment hepatectomy was performed for definitive diagnosis and treatment. The resection specimen showed a yellowish-white lesion measuring 15 mm in diameter. Pathological examination showed a granulomatous lesion with cholesterol crystals surrounded by foreign body giant cells. The lesion was diagnosed as cholesterol granuloma of the liver. The postoperative course was good, and the patient was discharged on postoperative day 5. She was healthy, and no recurrence of the cholesterol granuloma was detected at the 5-month follow-up. This is the first case report of cholesterol granuloma of the liver mimicking a malignant liver tumor in a patient with no intrahepatic cholesterol stones.

  441. Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient

    Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

    Pediatric Transplantation　26　(2)　2022/03

    DOI： 10.1111/petr.14160 　

    ISSN： 1397-3142

    eISSN： 1399-3046

  442. Randomized phase III trial of intravenous and intraperitoneal paclitaxel with S-1 versus gemcitabine plus nab-paclitaxel for pancreatic ductal adenocarcinoma with peritoneal metastasis (SP study). International-journal

    Tomohisa Yamamoto, Tsutomu Fujii, Satoshi Hirano, Fuyuhiko Motoi, Goro Honda, Kenichiro Uemura, Joji Kitayama, Michiaki Unno, Yasuhiro Kodera, Hiroki Yamaue, Toshio Shimokawa, Daisuke Hashimoto, So Yamaki, Hideyuki Yoshitomi, Fumihiko Miura, Hideki Ueno, Mitsugu Sekimoto, Sohei Satoi

    Trials　23　(1)　119-119　2022/02/05

    DOI： 10.1186/s13063-022-06049-7 　

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    The prognosis of pancreatic ductal carcinoma (PDAC) with peritoneal metastasis remains dismal. Systemic chemotherapy alone may not be effective, and the combination of intraperitoneal chemotherapy with systemic chemotherapy is expected to prolong the overall survival in patients with peritoneal metastasis. We have designed a randomized phase III trial to confirm the superiority of intravenous (i.v.) and intraperitoneal (i.p.) paclitaxel (PTX) with S-1 relative to gemcitabine plus nab-PTX (GnP), which is the current standard therapy for patients with metastatic PDAC. A total of 180 patients will be accrued from 30 institutions within 3 years. Patients will be randomly assigned in a 1:1 ratio to receive either i.v. and i.p. PTX with S-1 or GnP (target of 90 patients per group). The primary endpoint is overall survival; secondary endpoints are progression-free survival, response rate, proportion with negative peritoneal washing cytology during chemotherapy, proportion requiring conversion surgery, and adverse event profiles. Japan Registry of Clinical Trials jRCTs051180199 ( https://jrct.niph.go.jp/ ).

  443. A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms. International-journal

    Tetsuya Takikawa, Kazuhiro Kikuta, Shin Hamada, Kiyoshi Kume, Shin Miura, Naoki Yoshida, Yu Tanaka, Ryotaro Matsumoto, Mio Ikeda, Fumiya Kataoka, Akira Sasaki, Hidehiro Hayashi, Waku Hatta, Yohei Ogata, Kei Nakagawa, Michiaki Unno, Atsushi Masamune

    Diagnostics (Basel, Switzerland)　12　(2)　2022/02/03

    DOI： 10.3390/diagnostics12020397 　

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    The management of non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) is still controversial. This study aimed to develop a new scoring system for treatment decisions at initial diagnosis based on the identification of the predictive factors for aggressive NF-PanNENs. Seventy-seven patients who had been pathologically diagnosed with NF-PanNENs were enrolled. We retrospectively reviewed 13 variables that could be assessed preoperatively. Univariate and multivariate stepwise logistic regression analyses were performed to identify factors for the aggressiveness of NF-PanNENs, and a scoring system was developed by assigning weighted points proportional to their β regression coefficient. Tumor size > 20 mm on contrast-enhanced computed tomography, tumor non-vascularity, and Ki-67 labeling index ≥5% on endoscopic ultrasound-guided fine-needle aspiration specimens were identified as independent factors for predicting the aggressiveness of NF-PanNENs. The new scoring system, developed using the identified factors, had an excellent discrimination ability, with area under the curve of 0.92 (95% CI, 0.85-0.99), and good calibration (p = 0.72, Hosmer-Lemeshow test). Ten-year overall survival rates in low-risk (0 point), intermediate-risk (1 to 2 points), and high-risk (3 to 4 points) groups were 100%, 90.9%, and 24.3%, respectively. This new scoring system would be useful for treatment decisions and prognostic prediction at initial diagnosis.

  444. Somatostatin Receptor 2 Expression Profiles and Their Correlation with the Efficacy of Somatostatin Analogues in Gastrointestinal Neuroendocrine Tumors. International-journal

    Hirofumi Watanabe, Fumiyoshi Fujishima, Izumi Komoto, Masayuki Imamura, Susumu Hijioka, Kazuo Hara, Yasushi Yatabe, Atsushi Kudo, Toshihiko Masui, Takahiro Tsuchikawa, Kazuhiro Sakamoto, Hisashi Shiga, Tomohiro Nakamura, Naoki Nakaya, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    Cancers　14　(3)　2022/02/02

    DOI： 10.3390/cancers14030775 　

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    Somatostatin analogues (SSAs) are widely used to treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Somatostatin receptor 2 (SSTR2) immunoreactivity serves as a predictive marker of the therapeutic efficacy of SSAs in pancreatic NETs. However, SSTR2 expression profiles in tumor cells and their association with the therapeutic efficacy of SSAs remains virtually unknown in gastrointestinal NETs (GI-NETs). Therefore, we evaluated the association between SSTR2 immunoreactivity and embryological origin and proliferative activity in 132 resected surgical tissues of GI-NETs. The correlation between SSAs' therapeutic efficacy and SSTR2 immunoreactivity was evaluated in 14 GI-NETs treated with SSAs. SSTR2 immunoreactivity was evaluated using Volante scores, immunoreactive scores, and digital image analysis (DIA). SSTR2 immunoreactivity was significantly negatively and positively correlated with the Ki-67 labeling index in foregut and hindgut NETs, respectively. In the normal mucosa, neuroendocrine cells in the rectum had significantly lower positive rates of SSTR2 than those in the stomach and duodenum. SSTR2 expression profiles in GI-NETs could differ by primary sites, while the difference of those between foregut and hindgut NETs might be derived from the SSTR2 status of normal neuroendocrine cell counterparts. In addition, DIA could provide a good alternative for predicting response to SSAs in evaluating SSTR2 immunoreactivity of GI-NETs.

  445. 炎症性腸疾患に対する緊急手術における内視鏡外科の立ち位置 クローン病の腹部救急症例に対する当科での外科治療

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本腹部救急医学会雑誌　42　(2)　243-243　2022/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  446. 回腸尿膜管瘻を合併したCrohn病の1例

    丸山 大貴, 渡辺 和宏, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 諸井 林太郎, 佐竹 洋平, 川崎 芳英, 方山 博路, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　42　(2)　337-337　2022/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  447. CMVハイリスク症例に対しエベロリムスを使用した5症例の検討

    戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 宮城 重人, 海野 倫明, 亀井 尚

    日本臨床腎移植学会プログラム・抄録集　55回　210-210　2022/02

    Publisher: (一社)日本臨床腎移植学会

  448. 回腸尿膜管瘻を合併したCrohn病の1例

    丸山 大貴, 渡辺 和宏, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 諸井 林太郎, 佐竹 洋平, 川崎 芳英, 方山 博路, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　42　(2)　337-337　2022/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  449. 脳死肺移植後の末期腎不全に対し生体腎移植を施行した1例

    齋藤 純健, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 渡邊 有為, 宮城 重人, 岡田 克典, 海野 倫明, 亀井 尚

    日本臨床腎移植学会プログラム・抄録集　55回　200-200　2022/02

    Publisher: (一社)日本臨床腎移植学会

  450. High Incidence of Lymph-node Metastasis in a Pancreatic-cancer Patient-derived Orthotopic Xenograft (PDOX) NOG-Mouse Model. International-journal

    Norihiko Sugisawa, Kentaro Miyake, Takashi Higuchi, Hiromichi Oshiro, Jun Ho Park, Kei Kawaguchi, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Anticancer research　42　(2)　739-743　2022/02

    DOI： 10.21873/anticanres.15532 　

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    BACKGROUND/AIM: Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) model. An important goal of PDOX-model development is facile visualization of metastasis in live mice. In the present report we evaluated tumor growth and metastasis in pancreatic cancer PDOX NOG [Non-obese diabetes (NOD)/Scid/IL2Rγnull]-and nude-mouse models using red fluorescent protein (RFP)-expressing tumor stroma to visualize the primary tumor and metastasis. MATERIALS AND METHODS: A patient-derived pancreatic cancer was initially implanted in transgenic RFP-expressing nude mice. Then, tumor fragments, which acquired RFP expressing stroma while growing in RFP-expressing nude mice were orthotopically implanted in nude and NOG mice. The primary pancreatic tumor and metastasis were observed 8 weeks after implantation. RESULTS: Lymph-node metastases expressing red fluorescence were detected only in NOG mice. Significantly faster growth of primary pancreatic tumors and a higher incidence of lymph-node metastasis occurred in NOG mice compared to nude mice. CONCLUSION: RFP-expressing tumor stroma, which traffics together with cancer cells to lymph nodes, is useful to observe tumor behavior, such as lymph-node metastasis in a PDOX NOG-mouse model which can be used for evaluation of novel anti-metastatic agents, as well as personalized therapy to identify effective drugs.

  451. Persistent fecal occult blood due to the small intestinal metastasis of pleomorphic lung carcinoma. International-journal

    Takaya Suzuki, Masafumi Noda, Akihiro Yamamura, Hisashi Ohishi, Hirotsugu Notsuda, Shunsuke Eba, Ryota Tanaka, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Yoshinori Okada

    Journal of surgical case reports　2022　(2)　rjac043　2022/02

    DOI： 10.1093/jscr/rjac043 　

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    The gastrointestinal tract is one of the locations that lung cancers cause metastasis. A 70-year-old male underwent right lower lobectomy while presenting fecal occult blood with a preoperative colonoscopy showing colon polyps as the cause. The pathological diagnosis was pleomorphic carcinoma of the lung, with stage pT3N0M0. Seven months after the lung surgery, the patient presented with sudden-onset abdominal pain and severe anemia. Computed tomography scanning revealed a large mass in the abdominal cavity, and subsequent intestinal endoscopy demonstrated jejunum tumors. Partial jejunum resection was successfully performed. The patient developed multiple peritoneal nodules suggesting metastatic tumors but well responded to an immune checkpoint inhibitor. It can be challenging to diagnose gastrointestinal metastasis in routine radiography; therefore, endoscopic examination, including the small intestine, might be an important option when a lung cancer patient with advanced clinical stage presents with abdominal symptoms, including fecal occult blood.

  452. Distribution of Amniotic Epithelial Cells After Intraportal Infusion in a Rat Model. International-journal

    Miyako Tanaka, Kazuaki Tokodai, Masato Sato, Shuhei Yamada, Hitomi Okita, Takako Ito, Masatoshi Saito, Tetsuro Hoshiai, Shigehito Miyagi, Toshio Miki, Michiaki Unno, Takashi Kamei, Masafumi Goto

    Transplantation proceedings　54　(2)　513-515　2022/01/13

    DOI： 10.1016/j.transproceed.2021.09.077 　

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    BACKGROUND: Human amniotic epithelial cells (hAECs) are increasingly gaining attention as novel sources for cell transplantation. In clinical practice, intraportal infusion is considered one of the leading approaches for transplantation; however, this has not yet been validated for in vivo transplantation of hAECs. Thus, this study aims to investigate the distribution of hAECs post intraportal infusion and compare this distribution with other cell administration routes. METHODS: Wistar/ST rats were divided into 4 groups (n = 3 for each) based on cell administration route: group 1, intraportal; group 2, the spleen; group 3, tail veins; and group 4, penile veins. Subsequently, hAECs (1 × 107) stained with XenoLight DiR were infused into each recipient. Cell distribution was evaluated using an in vivo imaging system. RESULTS: DiR signals were detected in the rat livers of groups 1 and 2 with those in group 2 being much weaker than those in group 1. Necrosis of small intestine was observed in 2 cases in group 2. DiR signals were detected in the lungs in groups 3 and 4 because of systemic circulation; however, all the animals died within 20 minutes of infusions. CONCLUSIONS: Intraportal infusion is potentially applicable for safe and efficient transplantation of hAECs into the liver, whereas hAECs administration via the spleen carries a risk of thrombosis in a narrow portal vein system. Our results also indicate that hAECs administration via the systemic circulation could cause pulmonary embolism in clinical settings.

  453. 短腸症候群に対する新規薬剤Teduglutide(テデュグルチド)のストーマに及ぼす影響の検討

    渡辺 和宏, 高橋 真紀, 神山 篤史, 市川 英孝, 小林 実, 梶原 大輝, 唐澤 秀明, 森川 孝則, 亀井 尚, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　38　(1)　207-207　2022/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  454. 組織混在型早期胃癌はリンパ節転移高リスクである

    川名 友美, 山村 明寛, 田中 直樹, 井本 博文, 杉沢 徳彦, 土屋 堯裕, 山崎 有人, 佐々木 啓迪, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　212回・167回　162-162　2022/01

    Publisher: 日本消化器病学会-東北支部

  455. 当院で手術を行った胃原発胎児消化管上皮類似癌の3例

    陳 梦格, 山村 明寛, 山崎 有人, 田中 直樹, 井本 博文, 土屋 尭裕, 杉沢 徳彦, 川名 友美, 佐々木 啓迪, 西條 文人, 笹野 公伸, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会・日本消化器内視鏡学会東北支部例会プログラム・抄録集　212回・167回　180-180　2022/01

    Publisher: 日本消化器病学会-東北支部

  456. 間歇性跛行を呈するAortoiliac Occlusive disease患者に対する血管内治療後の歩行の変化 三次元動作解析を用いた検討

    小笠原 紀信, 赤松 大二朗, 芹澤 玄, 田島 悠太, 梅津 道久, 堀井 晋一良, 高橋 宏和, 長岡 洋平, 石田 孝宜, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　31　(Suppl.)　P33-1　2022

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  457. Prognostic impact of postoperative circulating tumor DNA as a molecular minimal residual disease marker in patients with pancreatic cancer undergoing surgical resection

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　DOI: 10.1002/jhbp.1282　2022

    DOI： 10.1002/jhbp.1282 　

  458. Wnt2 in cancer-associated fibroblast is associated with lymph node metastasis in orthotopic model of colorectal cancer

    Karasawa, Hideaki, Miura, Koh, Sasaki, Hiroyuki, Kobayashi, Minoru, Kajiwara, Taiki, Kamei, Takashi, Ohnuma, Shinobu, Unno, Michiaki

    Cancer Science　2022

  459. [Postoperative complications, prognosis, and quality of life in elderly ulcerative colitis].

    Kazuhiro Watanabe, Shinobu Ohnuma, Michiaki Unno

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology　119　(11)　1009-1013　2022

    DOI： 10.11405/nisshoshi.119.1009 　

  460. Usefulness of Preoperative Controlling Nutritional Status in Predicting Prolonged Hospitalization and Incidence of Postoperative Delirium for Elderly Hepatectomy with Hepatocellular Carcinoma.

    Atsushi Fujio, Masahiro Usuda, Yasuyuki Hara, Yuta Kakizaki, Kaoru Okada, Go Miyata, Michiaki Unno, Takashi Kamei

    The Tohoku journal of experimental medicine　256　(1)　43-52　2022/01

    DOI： 10.1620/tjem.256.43 　

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    The number of elderly patients with hepatocellular carcinoma (HCC) has been increasing, but it remains unclear whether hepatectomy can be performed using the same criteria as in younger patients. Furthermore, the appropriate preoperative evaluation for hepatectomy in elderly patients is not yet clearly defined. Here, we investigated the applicability of preoperative assessment using the Controlling Nutritional Status (CONUT) score to help improve hepatectomy outcomes in elderly patients with HCC. This was a single-center retrospective analysis, and the study population comprised 64 consecutive patients who underwent hepatectomy for HCC between January 2012 and August 2016. We compared the preoperative assessment and perioperative outcomes between elderly (≥ 75 years old) and younger (< 75 years old) patients. A total of 61 patients were reviewed. Poor preoperative CONUT score was associated with a longer postoperative hospital stay in elderly patients undergoing hepatectomy for HCC. In addition, although elderly patients had similar perioperative outcomes to younger patients, the incidence of delirium was significantly higher, and univariate analysis confirmed that old age is a risk factor for delirium among the preoperative factors. Hepatectomy for HCC in the elderly can be safely performed with appropriate preoperative nutritional assessment using CONUT score and prevention of postoperative delirium. Preoperative nutritional assessment using the CONUT score was useful in predicting prolonged hospitalization for elderly hepatectomy with HCC.

  461. What is the impact of zinc deficiency for pancreatectomies in patients with pancreatic ductal adenocarcinoma? International-journal

    Masahiro Iseki, Masamichi Mizuma, Shuichi Aoki, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　2021/12/31

    DOI： 10.1016/j.pan.2021.12.006 　

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    BACKGROUND: and purpose: Zinc is an essential element for human health and plays an important role in metabolic, immunological and other biological processes. The present study was conducted to investigate the association between zinc deficiency (ZD) and the perioperative clinical course in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Of 216 patients with PDAC who underwent elective pancreatectomy between 2013 and 2017 at our institution, 206 patients with sufficient clinical data were retrospectively reviewed. The perioperative variables were compared and the risk factors associated with infectious complications were identified. RESULTS: ZD was preoperatively present in 36 (17.5%) of 206 patients with PDAC. In the patients of the ZD group, a higher proportion of males, higher preoperative modified Glasgow prognostic scores, a higher neutrophil-to-lymphocyte ratio, and a higher occurrence of postoperative infectious complications after pancreatectomy were observed, compared to the non-ZD group. By a univariate analysis, three risk factors were significantly associated with infectious complications after pancreatectomy: ZD (vs non-ZD: p = 0.002), serum albumin <3.5 g/dl (vs ≥ 3.5 g/dl: p = 0.005), and the procedure of pancreaticoduodenectomy (vs others: p = 0.013). By multivariate logistic regression analysis, the occurrence of infectious complications was significantly associated with ZD (OR 3.430, 95%CI 1.570 to 7.490, p = 0.002) and the procedure of pancreaticoduodenectomy (OR 2.030, 95%CI 1.090 to 3.770, p = 0.025). CONCLUSIONS: The current study newly demonstrated that ZD could serve as a preoperative predictor of infectious complications after pancreatectomies in the patients with PDAC.

  462. Incidence and risk factors of nonalcoholic fatty liver disease after total pancreatectomy: A first multicenter prospective study in Japan.

    Hiroyuki Kato, Keiko Kamei, Hironobu Suto, Takeyuki Misawa, Michiaki Unno, Hiroyuki Nitta, Sohei Satoi, Yasunari Kawabata, Masayuki Ohtsuka, Toshiki Rikiyama, Takeshi Sudo, Ippei Matsumoto, Keiichi Okano, Yasuyuki Suzuki, Naohiro Sata, Shuji Isaji, Masanori Sugiyama, Yoshifumi Takeyama

    Journal of hepato-biliary-pancreatic sciences　29　(4)　428-438　2021/12/04

    DOI： 10.1002/jhbp.1093 　

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    BACKGROUND/PURPOSE: In the present study we aimed to prospectively assess the current prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) after total pancreatectomy (TP). METHODS: Between August 2015 and December 2017, we prospectively collected data from 68 Japanese centers on 148 consecutive patients who underwent TP whose computed tomography (CT) attenuation values were evaluated for 12 months. We defined post-TP NAFLD as a liver parenchyma CT value of less than 40 Hounsfield units (HU). Data on perioperative variables were retrieved from all patients and evaluated using univariate and multivariate analyses to identify the perioperative risk factors of NAFLD. RESULTS: In this prospective cohort study, supplementation of pancreatic exocrine enzymes was provided to all 148 patients, and 97% of them were treated with high-titer pancrelipase (median dosage: 1800 mg) postoperatively. Indeed, 29 patients (19.6%) developed NAFLD within a year after TP. Multivariate analysis revealed that female sex (P = .002), higher body mass index (BMI) (P = .001), and postoperative diarrhea (P = .038) were independent risk factors for post-TP NAFLD. However, post-TP NAFLD ameliorated in 11 patients (37.9%) at 12 months after surgery. CONCLUSIONS: Among patients with risk factors such as female sex, higher BMI, and postoperative diarrhea, attention should be paid to the occurrence of NAFLD after TP.

  463. 術前化学療法が奏効し根治切除が可能であった膀胱浸潤巨大S状結腸癌の1例

    佐藤 将大, 小林 実, 唐澤 秀明, 市川 英孝, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    癌と化学療法　48　(13)　1764-1766　2021/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  464. 潰瘍性大腸炎に対する腹腔鏡下大腸全摘、回腸嚢肛門吻合後に腸回転異常症が明らかとなり腸閉塞を来した1例

    市川 英孝, 大沼 忍, 小林 実, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　MO010-4　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  465. 肥満を伴う直腸癌に対する直腸切断術 腹腔鏡とロボットの比較

    大沼 忍, 神山 篤史, 唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 杉沢 徳彦, 土屋 尭裕, 井本 博文, 山村 明寛, 田中 直樹, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　MO024-6　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  466. 腹腔鏡下直腸切除後の一時的人工肛門閉鎖部における腹壁瘢痕ヘルニア発生危険因子

    梶原 大輝, 大沼 忍, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　MO034-5　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  467. 導入初期のロボット支援下低位前方切除術の課題

    神山 篤史, 大沼 忍, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　MO208-6　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  468. 虫垂切除術の既往が大腸癌に対する腹腔鏡下右側結腸切除術に与える影響の検討

    小林 実, 大沼 忍, 市川 英孝, 梶原 大輝, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 杉沢 徳彦, 土屋 尭裕, 井本 博文, 山村 明寛, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　MO211-2　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  469. [Complete Response to Neoadjuvant Chemotherapy with Imatinib of a Large Gastric GIST-A Case Report].

    Tomomi Kawana, Hirofumi Imoto, Naoki Tanaka, Takeshi Aoki, Akihiro Yamamura, Takahiro Tsuchiya, Norihiko Sugisawa, Hiromichi Sasaki, Takanori Morikawa, Fumiyoshi Fujishima, Shinobu Onuma, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　48　(13)　1749-1751　2021/12

    ISSN： 0385-0684

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    A 54-year-old woman was presented with the intraabdominal mass to our hospital. Abdominal CT showed 22 cm tumor of the stomach with invasion to the pancreas and the spleen. Upper GI endoscopy showed submucosal tumor at the stomach body, and endoscopic US showed low echoic tumor. The tumor was diagnosed as gastric GIST by biopsy with c-kit positive cells. After 4 months of neoadjuvant therapy with imatinib, she underwent total gastrectomy, distal pancreatectomy and splenectomy. Histopathologically, there were no viable tumor cells in the resected specimen. The patient has no evidence of recurrence at 8 months post operation.

  470. [A Case of Remnant Gastric Cancer with Mesojejunal Lymph Node Metastasis].

    Hiromichi Sasaki, Takeshi Aoki, Akihiro Yamamura, Naoki Tanaka, Hirofumi Imoto, Takahiro Tsuchiya, Tomomi Kawana, Takanori Morikawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　48　(13)　2118-2120　2021/12

    ISSN： 0385-0684

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    A 62-year-old man underwent radical surgery for the treatment of remnant gastric cancer with mesojejunal lymph node metastasis. According to the 15th edition of the Japanese Gastric Cancer Association, a histological diagnosis of B-35-A, type 3, tub2>tub1, pT3(SS), pN3a(10/37), cM0, CY0, pStage ⅢB was made. All lymph node metastases were recognized in the mesojejunum. Adjuvant chemotherapy with S-1 plus docetaxel was initiated after 4 weeks of surgery. The patient is still alive without recurrence after 1 year of surgery. Thus, radical surgery with dissection of the mesojejunum and intensive adjuvant chemotherapy might improve the prognosis in a remnant gastric cancer patient with mesojejunal lymph node metastasis.

  471. [A Case of Rectal Cancer with Disseminated Intravascular Coagulation Successfully Treated with Emergent Chemotherapy].

    Tatsushi Saito, Hideaki Karasawa, Yuri Hatsuzawa, Minoru Kobayashi, Taiki Kajiwara, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　48　(13)　1625-1627　2021/12

    ISSN： 0385-0684

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    A 70's woman complaining blood stool and lower abdominal pain visited a local doctor and was given the diagnosis of rectal cancer by colonoscopy. CT, MRI, and bone scintigraphy revealed multiple lymph node and bone metastasis and peritoneal dissemination. She had developed disseminated intravascular coagulation(DIC)during hospitalization, and the cause was considered to be disseminated carcinomatosis of the bone marrow. Thus, we emergently started chemotherapy with mFOLFOX6, in conjunction with anticoagulation therapy, and the DIC was resolved 11 days after the introduction. Partial response was achieved and the chemotherapy has been continued after 5 months from the onset of the DIC. Since the prognosis of solid tumor patients who developed DIC has been reported to be extremely poor, prompt introduction of chemotherapy should be considered.

  472. [A Case of Curative Resection after Neoadjuvant Chemotherapy for Locally-Advanced Sigmoid Colon Carcinoma with Urinary Bladder Invasion].

    Yukihiro Sato, Minoru Kobayashi, Hideaki Karasawa, Hidetaka Ichikawa, Taiki Kajiwara, Atsushi Kohyama, Kazuhiro Watanabe, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　48　(13)　1764-1766　2021/12

    ISSN： 0385-0684

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    A 56-year-old man was referred to our hospital for multidisciplinary treatment of advanced sigmoid colon carcinoma with a suspected bladder invasion. The patient received 8 courses of modified Leucovorin, fluorouracil, and oxaliplatin (mFOLFOX6)plus panitumumab as neoadjuvant chemotherapy for reliable and safe radical resection after ileostomy construction. There was a significant reduction in the tumor size following chemotherapy; hence, low anterior resection was performed. In addition, since preoperative and intraoperative findings suggested bladder invasion, a total cystectomy with ileal conduit urinary diversion was performed. The pathological diagnosis was ypT4b, N0, M0, and ypStage Ⅱc, with all surgical margins being negative. Subsequently, the patient received adjuvant chemotherapy with 4 courses of mFOLFOX6, and his condition improved with no incidence of cancer recurrence following 8 months after the operation. Neoadjuvant chemotherapy for locally advanced colon cancer is one of the effective treatments for reliable and safe radical resection.

  473. 鏡視下胆道再建術-安全な普及を目指した戦略について- 定型化を目指した先天性胆道拡張症成人例に対する腹腔鏡下肝外胆管切除・胆道再建術

    森川 孝則, 石田 晶玄, 三浦 孝之, 千葉 和治, 青木 修一, 堂地 大輔, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 水間 正道, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　26　(7)　CSY18-2　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  474. 浅大腿静脈グラフトを用いて門脈・上腸間膜静脈再建を施行した膵頭部癌の1例

    海野 裕一郎, 水間 正道, 赤松 大二朗, 青木 修一, 伊関 雅裕, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 粂 潔, 正宗 淳, 海野 倫明

    癌と化学療法　48　(13)　1783-1785　2021/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  475. 術前化学療法が奏効し根治切除が可能であった膀胱浸潤巨大S状結腸癌の1例

    佐藤 将大, 小林 実, 唐澤 秀明, 市川 英孝, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    癌と化学療法　48　(13)　1764-1766　2021/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  476. Quantitative digital image analysis of somatostatin receptor 2 immunohistochemistry in pancreatic neuroendocrine tumors.

    Hirofumi Watanabe, Rioko Ide, Yuto Yamazaki, Fumiyoshi Fujishima, Atsuko Kasajima, Samaneh Yazdani, Tomoyoshi Tachibana, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    Medical molecular morphology　54　(4)　324-336　2021/12

    DOI： 10.1007/s00795-021-00294-6 　

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    Immunohistochemical analysis of somatostatin receptor 2 (SSTR2) provides important information regarding the potential therapeutic efficacy of somatostatin analogues (SSAs) in patients with neuroendocrine tumors. HER2 scoring has been proposed to interpret SSTR2 immunoreactivity but their reproducibility was relatively low because of its intrinsic subjective nature. Digital image analysis (DIA) has recently been proposed as an objective and more precise method of evaluating immunoreactivity. Therefore, in this study, we used DIA for analyzing SSTR2 immunoreactivity in pancreatic neuroendocrine tumors (PanNETs) to obtain its H score and "(%) strong positive cells" and compared the results with those of manually obtained HER2 scores. Membranous SSTR2 immunoreactivity evaluated by DIA was calculated by two scales as: "Membrane Optical Density" and "Minimum Membrane Completeness". PanNETs with HER2 score of > 2 demonstrated the highest concordance with results of "(%) strong positive cells" obtained by DIA when "Minimum Membrane Completeness" was tentatively set at 80%. The SSTR2 immunoreactivity, evaluated based on all scoring systems, was different between grades G1 and G2 in insulinoma but not in non-functional PanNETs. DIA provided reproducible results of SSTR2 immunoreactivity in PanNETs and yielded important information as to the potential application of SSAs.

  477. [Reconstruction of Portal Vein and Superior Mesenteric Vein Using Superficial Femoral Vein Graft in Surgical Resection of Pancreatic Head Cancer-A Case Report].

    Yuichiro Umino, Masamichi Mizuma, Daijiro Akamatsu, Shuichi Aoki, Masahiro Iseki, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Kiyoshi Kume, Atsushi Masamune, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　48　(13)　1783-1785　2021/12

    ISSN： 0385-0684

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    We report a case of reconstruction of the portal vein(PV)and superior mesenteric vein(SMV)using a superficial femoral vein graft in total pancreatectomy for pancreatic cancer. A 62-year-old man visited a previous hospital due to epigastric pain and bilirubinuria and was diagnosed with pancreatic cancer. The patient was referred to our hospital for further examination and treatment. Abdominal CT scan revealed a 30 mm pancreatic head tumor with an abutment of almost 360 degrees around the superior mesenteric artery(SMA)and extensive involvement from the PV to branches of the SMV, radiologically classified as locally advanced unresectable pancreatic cancer. Although gemcitabine plus nab-paclitaxel combination therapy(GnP)was performed, the patient developed drug-induced lung injury after 3 courses. GnP was stopped, and chemoradiation therapy with S-1 was performed. After chemoradiation therapy, the tumor shrank to 14 mm, while no change of the abutment around SMA was observed. After 8 months from the initial diagnosis, total pancreatectomy and resection of the PV/SMV were performed. Approximately 70 mm of the PV/SMV was surgically removed and was reconstructed using a graft from the left superficial femoral vein in consideration of the length and diameter. Although delayed gastric emptying was postoperatively observed, the patient was discharged 39 days after operation, then received adjuvant therapy with S-1. The patient is alive without recurrence and the patency of PV/SMV was well maintained.

  478. Probiotic-related bacteremia after major hepatectomy for biliary cancer: a report of two cases

    Mitsuhiro Shimura, Masamichi Mizuma, Kei Nakagawa, Shuichi Aoki, Takayuki Miura, Tatsuyuki Takadate, Kyohei Ariake, Shimpei Maeda, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Surgical Case Reports　7　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40792-021-01216-5 　

    eISSN： 2198-7793

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    <title>Abstract</title><sec> <title>Background</title> Probiotics have been reported to be beneficial for the prevention of postoperative complications and are often used during the perioperative period. Among the probiotic-related adverse events, bacteremia is rare. Here, we report two cases of probiotic-related bacteremia after major hepatectomy for biliary cancer. </sec><sec> <title>Case presentation 1</title> A 74-year-old man was referred to our hospital to be treated for gallbladder cancer. Neoadjuvant chemotherapy, two courses of gemcitabine plus S-1 combination therapy, was administered. Extended right hepatectomy with caudate lobectomy, extrahepatic bile duct resection and biliary reconstruction were performed 3 weeks after chemotherapy. Probiotics, <italic>Clostridium butyricum</italic> (<italic>C. butyricum</italic>) MIYAIRI 588, were administered 6 days before surgery and continued after surgery. Sepsis of unknown origin occurred 17 days after surgery and developed into septic shock. <italic>C. butyricum</italic> was detected in blood cultures at postoperative day 26 and 45. After stopping the probiotic agent, <italic>C. butyricum</italic> was undetectable in the blood cultures. The patient died due to an uncontrollable sepsis 66 days after surgery. </sec><sec> <title>Case presentation 2</title> A 63-year-old man with diabetes mellitus whose past history included total colectomy, papillectomy, and Frey’s operation at the age of 19, 34 and 48, respectively, was referred to our hospital to be treated for perihilar cholangiocarcinoma. Extended left hepatectomy with caudate lobectomy, extrahepatic bile duct resection and reconstruction of bile duct were performed. Probiotics were administered during the perioperative period. Combined probiotics that included lactomin, amylolytic bacillus and <italic>C. butyricum</italic>, were given before surgery. <italic>C. butyricum</italic> MIYAIRI 588 was given after surgery. Sepsis occurred 16 days after surgery and developed to respiratory failure 8 days later. Blood culture at postoperative day 25 revealed <italic>Enterococcus faecalis</italic> and <italic>C. butyricum</italic>. After the probiotics were stopped at postoperative day 27, <italic>C. butyricum</italic> was not detected in the blood culture. The general condition improved with intensive care. The patient was transferred to another hospital for rehabilitation at postoperative day 156. </sec><sec> <title>Conclusion</title> It should be noted that the administration of probiotics in severe postoperative complications can lead to probiotic-related bacteremia. </sec>

  479. A long-term survivor of metachronous liver metastases of pancreatic serous cystic neoplasm associated with von Hippel–Lindau disease

    Takashi Kokumai, Masamichi Mizuma, Katsuya Hirose, Hideaki Karasawa, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Atsushi Masamune, Toru Furukawa, Michiaki Unno

    Surgical Case Reports　7　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40792-021-01239-y 　

    eISSN： 2198-7793

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    <title>Abstract</title><sec> <title>Background</title> Pancreatic serous cystic neoplasm (SCN) is an uncommon exocrine neoplasm, which is believed to be a benign entity. However, some of these neoplasms may occasionally attain metastatic ability. Von Hippel–Lindau disease (VHL) manifests a dominantly inherited systemic syndrome accompanied by several benign or malignant tumors, including cystic tumors, in various organs. We describe here a long-term survival case who underwent surgical resection for metachronous liver metastases of pancreatic SCN associated with VHL disease. </sec><sec> <title>Case presentation</title> A 35-year-old woman with VHL underwent total pancreatectomy and right nephrectomy for pancreatic SCN and renal cell carcinoma, respectively. At the 4th year follow-up examination after the resection, contrast-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) showed arterially hyper-enhanced neoplastic lesions in the segment VI and VIII of the liver. Partial resections of the liver were performed 53 months after the initial surgery. At the 6th month follow-up examination from the second surgery, one and two tumors located in the liver segment III, and VIII, respectively, were detected by contrast-enhanced CT and Gd-EOB-DTPA-enhanced MRI. Anterior segmentectomy and partial resection of the segment III were performed 66 months after the initial surgery and 13 months after the second, respectively. The tumors were pathologically diagnosed as liver metastases of pancreatic SCN synonymous with serous cystadenocarcinoma. She remains disease-free without recurrence 6.5 years after the last operation. </sec><sec> <title>Conclusions</title> This is the first report of a case of metastatic SCN associated with VHL. Surgical resection might confer a favorable prognosis in patients of pancreatic SCN with liver metastases. </sec>

  480. Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

    Thanpisit Lomphithak, Perawatt Akara-amornthum, Keigo Murakami, Masatoshi Hashimoto, Hajime Usubuchi, Erina Iwabuchi, Michiaki Unno, Zhenyu Cai, Hironobu Sasano, Siriporn Jitkaew

    Scientific Reports　11　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-021-89977-9 　

    eISSN： 2045-2322

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    <title>Abstract</title>Necroptosis, a regulated form of necrosis, has emerged as a novel therapeutic strategy that could enhance cancer immunotherapy. However, its role in tumorigenesis is still debated because recent studies have reported both anti- and pro-tumoral effects. Here, we aimed to systematically evaluate the associations between tumor necroptosis (mixed lineage kinase domain-like protein, MLKL; phosphorylated MLKL, pMLKL; and receptor-interacting protein kinase 1–receptor-interacting protein kinase 3, RIPK1–RIPK3 interaction) and tumor-infiltrating immune cells (CD8+ and FOXp3+ T cells and CD163+ M2 macrophages) and tumor PD-L1 by immunohistochemistry in 88 cholangiocarcinoma (CCA) patients who had undergone surgical resection. Their associations with clinicopathological characteristics, survival data, and prognosis were evaluated. MLKL was found to be an unfavorable prognostic factor (<italic>p-</italic>value = 0.023, HR = 2.070) and was inversely correlated with a clinically favorable immune cell signature (high CD8+/high FOXp3+/low CD163+). Both pMLKL and RIPK1–RIPK3 interaction were detected in CCA primary tissues. In contrast to MLKL, pMLKL status was significantly positively correlated with a favorable immune signature (high CD8+/high FOXp3+/low CD163+) and PD-L1 expression. Patients with high pMLKL-positive staining were significantly associated with an increased abundance of CD8+ T cell intratumoral infiltration (<italic>p</italic>-value = 0.006). Patients with high pMLKL and PD-L1 expressions had a longer overall survival (OS). The results from in vitro experiments showed that necroptosis activation in an RMCCA-1 human CCA cell line selectively promoted proinflammatory cytokine and chemokine expression. Jurkat T cells stimulated with necroptotic RMCCA-1-derived conditioned medium promoted PD-L1 expression in RMCCA-1. Our findings demonstrated the differential associations of necroptosis activation (pMLKL) and MLKL with a clinically favorable immune signature and survival rates and highlighted a novel therapeutic possibility for combining a necroptosis-based therapeutic approach with immune checkpoint inhibitors for more efficient treatment of CCA patients.

  481. A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo

    Shoji Kokubo, Shinobu Ohnuma, Megumi Murakami, Haruhisa Kikuchi, Shota Funayama, Hideyuki Suzuki, Taiki Kajiwara, Akihiro Yamamura, Hideaki Karasawa, Norihiko Sugisawa, Kosuke Ohsawa, Kuniyuki Kano, Junken Aoki, Takayuki Doi, Takeshi Naitoh, Suresh V. Ambudkar, Michiaki Unno

    International Journal of Molecular Sciences　22　(22)　12502-12502　2021/11/19

    Publisher: MDPI AG

    DOI： 10.3390/ijms222212502 　

    eISSN： 1422-0067

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    The ATP-binding cassette subfamily G member 2 (ABCG2) transporter is involved in the development of multidrug resistance in cancer patients. Many inhibitors of ABCG2 have been reported to enhance the chemosensitivity of cancer cells. However, none of these inhibitors are being used clinically. The aim of this study was to identify novel ABCG2 inhibitors by high-throughput screening of a chemical library. Among the 5812 compounds in the library, 23 compounds were selected in the first screening, using a fluorescent plate reader-based pheophorbide a (PhA) efflux assay. Thereafter, to validate these compounds, a flow cytometry-based PhA efflux assay was performed and 16 compounds were identified as potential inhibitors. A cytotoxic assay was then performed to assess the effect these 16 compounds had on ABCG2-mediated chemosensitivity. We found that the phenylfurocoumarin derivative (R)-9-(3,4-dimethoxyphenyl)-4-((3,3-dimethyloxiran-2-yl)methoxy)-7H-furo [3,2-g]chromen-7-one (PFC) significantly decreased the IC50 of SN-38 in HCT-116/BCRP colon cancer cells. In addition, PFC stimulated ABCG2-mediated ATP hydrolysis, suggesting that this compound interacts with the substrate-binding site of ABCG2. Furthermore, PFC reversed the resistance to irinotecan without causing toxicity in the ABCG2-overexpressing HCT-116/BCRP cell xenograft mouse model. In conclusion, PFC is a novel inhibitor of ABCG2 and has promise as a therapeutic to overcome ABCG2-mediated MDR, to improve the efficiency of cancer chemotherapy.

  482. The impact of COVID-19 on surgical procedures in Japan: analysis of data from the National Clinical Database

    Norihiko Ikeda, Hiroyuki Yamamoto, Akinobu Taketomi, Taizo Hibi, Minoru Ono, Naoki Niikura, Iwao Sugitani, Urara Isozumi, Hiroaki Miyata, Hiroaki Nagano, Michiaki Unno, Yuko Kitagawa, Masaki Mori

    Surgery Today　2021/11/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00595-021-02406-2 　

    ISSN： 0941-1291

    eISSN： 1436-2813

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    <title>Abstract</title><sec> <title>Background and purpose</title> The spread of COVID-19 has restricted the delivery of standard medical care to surgical patients dramatically. Surgical triage is performed by considering the type of disease, its severity, the urgency for surgery, and the condition of the patient, in addition to the scale of infectious outbreaks in the region. The purpose of this study was to evaluate the impact of the COVID-19 pandemic on the number of surgical procedures performed and whether the effects were more prominent during certain periods of widespread infection and in the affected regions. </sec><sec> <title>Methods</title> We selected 20 of the most common procedures from each surgical field and compared the weekly numbers of each operation performed in 2020 with the respective numbers in 2018 and 2019, as recorded in the National Clinical Database (NCD). The surgical status during the COVID-19 pandemic as well as the relationship between surgical volume and the degree of regional infection were analyzed extensively. </sec><sec> <title>Results</title> The rate of decline in surgery was at most 10–15%. Although the numbers of most oncological and cardiovascular procedures decreased in 2020, there was no significant change in the numbers of pancreaticoduodenectomy and aortic replacement procedures performed in the same period. </sec><sec> <title>Conclusion</title> The numbers of most surgical procedures decreased in 2020 as a result of the COVID-19 pandemic; however, the precise impact of surgical triage on decrease in detection of disease warrants further investigation. </sec>

  483. Impact of Tumor-Derived DNA Testing in Peritoneal Lavage of Pancreatic Cancer Patients with and Without Occult Intra-Abdominal Metastases. International-journal

    Kazuharu Chiba, Tatsuo Hata, Masamichi Mizuma, Kunihiro Masuda, Shuichi Aoki, Tatsuyuki Takadate, Kei Kawaguchi, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Toru Furukawa, Michiaki Unno

    Annals of surgical oncology　2021/11/05

    DOI： 10.1245/s10434-021-10997-w 　

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    BACKGROUND: The fractional abundance of tumor-derived DNA in body fluids depends on the metastatic sites and the degree of expansion. We aimed to assess the clinical significance of tumor-derived DNA testing in the peritoneal lavage of patients with pancreatic cancer. METHODS: The prevalence and abundance of tumor-derived DNA was assessed in 204 subjects with ascites by peritoneal lavage (AS) and the evaluable paired plasma (PL) from 149 pancreatic cancer patients undergoing abdominal exploration. Genetic profiles were evaluated by next-generation sequencing, and prognostic impact was assessed using Cox proportional hazard models. RESULTS: Of 204 subjects, AS samples from patients with peritoneal dissemination (PER+) and positive cytology (CY+) showed significantly higher prevalence and abundance of tumor-derived DNA than those with negative counterparts. Tumor-derived DNA prevalence and abundance in AS were more likely to be higher than in paired PL in a subgroup of patients with PER+ and CY+, respectively. Next-generation sequencing revealed concordant or discrepant mutational patterns between the AS and PL samples. Multivariate analysis showed that both tumor-derived DNA in AS (hazard ratio [HR] 3.940, p = 0.009) and PL (HR 2.936, p = 0.026) were independently associated with poor survival in treatment-naïve patients. In patients who underwent resection, tumor-derived DNA positivity in the AS was more predictive of early recurrence than in PL. CONCLUSIONS: Tumor-derived DNA in AS can serve as characterizing the genetic profiles of tumor cells attributable to the development of PER+ and predicting the minimal residual disease and early recurrence in patients with pancreatic cancer.

  484. 【膵・胆道癌における薬物療法のすべて】がん薬物療法のエビデンス 切除可能膵癌に対する術前補助療法

    中川 圭, 元井 冬彦, 水間 正道, 海野 倫明

    胆と膵　42　(臨増特大)　1093-1100　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  485. 【胆と膵のスペシャリストが取るべき専門医/指導医とは?】膵癌登録について 登録の実際

    水間 正道, 海野 倫明, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 仲田 興平, 濱田 晋, 安田 一朗, 竹山 宜典

    胆と膵　42　(11)　1371-1374　2021/11

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  486. Arterio-Enteric FistulaにおけるBridge Therapyとして有効であったステントグラフトの使用経験

    堀井 晋一良, 赤松 大二朗, 後藤 均, 芹澤 玄, 吉田 良太朗, 田島 悠太, 梅津 道久, 高橋 宏和, 小笠原 紀信, 長岡 洋平, 三塚 浩二, 大沼 忍, 海野 倫明, 亀井 尚

    血管外科　40　(1)　82-88　2021/11

    Publisher: 血管外科症例検討会

  487. 消化器外科領域における周術期感染対策 術前亜鉛欠乏が膵癌周術期に与える影響の検討

    伊関 雅裕, 水間 正道, 青木 修一, 堂地 大輔, 三浦 孝之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　18　(1)　141-141　2021/11

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  488. Doppler ultrasonography is a useful tool for the diagnosis of hemodynamics in congestive graft injury due to heart failure after liver transplantation: A case report

    Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    International Journal of Surgery Case Reports　88　106569-106569　2021/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.ijscr.2021.106569 　

    ISSN： 2210-2612

  489. Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020 (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012)

    Nakazawa Takahiro, Kamisawa Terumi, Okazaki Kazuichi, Kawa Shigeyuki, Tazuma Susumu, Nishino Takayoshi, Inoue Dai, Naitoh Itaru, Watanabe Takayuki, Notohara Kenji, Kubota Kensuke, Ohara Hirotaka, Tanaka Atsushi, Takikawa Hajime, Masamune Atsushi, Unno Michiaki

    Tando　35　(4)　593-601　2021/10/31

    Publisher: Japan Biliary Association

    DOI： 10.11210/tando.35.593 　

    ISSN： 0914-0077

    eISSN： 1883-6879

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    Several years have passed since the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012 were published. New findings and knowledge have accumulated since then. The Research Committees for IgG4-related Diseases and for Intractable Diseases of the Liver and Biliary Tract, in association with the Ministry of Health, Labor, and Welfare of Japan and the Japan Biliary Association, have established a working group consisting of researchers specializing in IgG4-SC and have drawn up new clinical diagnostic criteria for IgG4-SC 2020. The diagnosis of IgG4-SC is based on a combination of the following six criteria: (a) narrowing of the intra- or extrahepatic bile duct; (b) thickening of the bile duct wall; (c) serological findings; (d) pathological findings; (e) other organ involvement; and (f) effectiveness of steroid therapy. These new diagnostic criteria for IgG4-SC are useful in practice for general physicians and other non-specialists.

  490. Intravenous injection of human multilineage-differentiating stress-enduring cells alleviates mouse severe acute pancreatitis without immunosuppressants

    Masahiko Fukase, Naoaki Sakata, Yoshihiro Kushida, Shohei Wakao, Michiaki Unno, Mari Dezawa

    Surgery Today　2021/10/23

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00595-021-02382-7 　

    ISSN： 0941-1291

    eISSN： 1436-2813

  491. Predictors of early and late mortality after the treatment for early gastric cancers. International-journal

    Yohei Ogata, Waku Hatta, Yuki Ohara, Tomoyuki Koike, Hiroko Abe, Masahiro Saito, Xiaoyi Jin, Takeshi Kanno, Kaname Uno, Naoki Asano, Akira Imatani, Akihiro Yamamura, Naoki Tanaka, Takashi Kamei, Michiaki Unno, Tomohiro Nakamura, Naoki Nakaya, Atsushi Masamune

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society　34　(4)　816-825　2021/10/18

    DOI： 10.1111/den.14172 　

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    OBJECTIVES: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately. METHODS: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years. RESULTS: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality. CONCLUSION: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality.

  492. オキサリプラチン誘発性末梢神経障害に対するシスチンとテアニンの経口摂取の保護的な効果 予備的無作為化試験(Protective effect of the oral administration of cystine and theanine on oxaliplatin-induced peripheral neuropathy: A pilot randomized trial)

    小林 実, 佐藤 龍一郎, 市川 英孝, 赤澤 直也, 矢澤 貴, 阿部 友哉, 岡田 恭穂, 柿田 徹也, 及川 昌也, 大沼 忍, 海野 倫明, 土屋 誉

    学会誌JSPEN　3　(Suppl.1)　87-87　2021/10

    Publisher: (一社)日本栄養治療学会

    eISSN： 2434-4966

  493. 移植後de novo発がんに関する諸問題 当院における肝移植後de novo発癌についての検討

    金井 哲史, 藤尾 淳, 西牧 宏泰, 齋藤 純健, 松村 宗幸, 佐々木 健吾, 宮澤 恒持, 柏舘 俊明, 戸子台 和哲, 宮城 重人, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　82　(増刊)　S234-S234　2021/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  494. 炎症性腸疾患に対する外科治療介入の見極めとタイミング 高齢発症潰瘍性大腸炎患者の外科治療介入のタイミング

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 田中 直樹, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　82　(増刊)　S219-S219　2021/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  495. 下部消化管神経内分泌腫瘍の治療方針 膵・消化管神経内分泌腫瘍診療ガイドラインによる直腸神経内分泌腫瘍切除例の検討

    梶原 大輝, 大沼 忍, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　82　(増刊)　S387-S387　2021/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  496. 腹腔鏡下直腸切断術における最適な人工肛門造設法の検討

    唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　82　(増刊)　S523-S523　2021/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  497. 悪性腫瘍との鑑別が困難であり腹腔鏡下肝切除術を施行した肝コレステロール肉芽腫の1例

    石川 裕貴, 藤尾 淳, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 宮城 重人, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　82　(増刊)　S776-S776　2021/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  498. 当院における黄色肉芽腫性胆嚢炎の検討

    吉田 直樹, 粂 潔, 池田 未緒, 佐野 貴紀, 田中 裕, 松本 諒太郎, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 中川 圭, 森川 孝則, 海野 倫明, 正宗 淳

    日本消化器病学会雑誌　118　(臨増大会)　A708-A708　2021/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  499. 【膵と胆道の先天性形成異常〜発生から臨床まで〜】膵動静脈奇形

    堂地 大輔, 水間 正道, 海野 倫明

    胆と膵　42　(10)　947-951　2021/10

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  500. 切除不能消化器癌に対するconversion surgeryの適応とタイミング 術前治療時代における膵癌微小遠隔転移に対するコンバージョン切除を企図した治療戦略

    有明 恭平, 水間 正道, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　59回　WS17-5　2021/10

    Publisher: (一社)日本癌治療学会

  501. 膵癌に対するnal-IRI療法の治療効果および安全性の検討

    森川 孝則, 青木 修一, 伊関 雅裕, 三浦 孝之, 堂地 大輔, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　59回　O43-5　2021/10

    Publisher: (一社)日本癌治療学会

  502. 当院における黄色肉芽腫性胆嚢炎の検討

    吉田 直樹, 粂 潔, 池田 未緒, 佐野 貴紀, 田中 裕, 松本 諒太郎, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 中川 圭, 森川 孝則, 海野 倫明, 正宗 淳

    日本消化器病学会雑誌　118　(臨増大会)　A708-A708　2021/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  503. 膵癌に対する予防域を含めた放射線治療における3DCRTとIMRTでの急性期有害事象の比較

    梅澤 玲, 中川 圭, 水間 正道, 山本 貴也, 石川 陽二郎, 海野 倫明, 神宮 啓一

    日本癌治療学会学術集会抄録集　59回　O52-6　2021/10

    Publisher: (一社)日本癌治療学会

  504. 繰り返す膵炎で発症した腸回転異常合併膵・胆管合流異常の1例

    佃 和彦, 大塚 英郎, 石田 晶玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 粂 潔, 大森 優子, 正宗 淳, 古川 徹, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　54　(10)　711-720　2021/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  505. ヒト羊膜由来細胞移植後の即時型炎症反応と免疫応答の解析と制御

    戸子台 和哲, 田中 美也子, 佐藤 将人, 山田 修平, 齋藤 昌利, 星合 哲郎, 宮城 重人, 三木 敏生, 海野 倫明, 亀井 尚, 後藤 昌史

    Organ Biology　28　(3)　93-93　2021/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  506. オキサリプラチン誘発性末梢神経障害に対するシスチンとテアニンの経口摂取の保護的な効果 予備的無作為化試験(Protective effect of the oral administration of cystine and theanine on oxaliplatin-induced peripheral neuropathy: A pilot randomized trial)

    小林 実, 佐藤 龍一郎, 市川 英孝, 赤澤 直也, 矢澤 貴, 阿部 友哉, 岡田 恭穂, 柿田 徹也, 及川 昌也, 大沼 忍, 海野 倫明, 土屋 誉

    学会誌JSPEN　3　(Suppl.1)　87-87　2021/10

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  507. 直腸癌に対するロボット手術 肥満が術後短期成績へ与える影響について

    大沼 忍, 神山 篤史, 唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 渡辺 和宏, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 山村 明寛, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　59回　O30-3　2021/10

    Publisher: (一社)日本癌治療学会

  508. The role of bilio-pancreatic limb in nonalcoholic steatohepatitis improvement after duodenal-jejunal bypass in rats. International-journal

    Hidetaka Ichikawa, Hirofumi Imoto, Naoki Tanaka, Fumiyoshi Fujishima, Takahiro Tsuchiya, Kazuhiro Watanabe, Takeshi Aoki, Atsushi Kohyama, Takanori Morikawa, Shinobu Ohnuma, Takeshi Naitoh, Takashi Kamei, Michiaki Unno

    Surgery　170　(4)　1006-1013　2021/10

    DOI： 10.1016/j.surg.2021.07.003 　

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    BACKGROUND: Nonalcoholic fatty liver disease, which is highly associated with obesity, includes nonalcoholic steatohepatitis. Lipopolysaccharides from the intestine would induce inflammation in the liver in nonalcoholic fatty liver disease. This study aimed to examine the role of the bilio-pancreatic limb in the effect of duodenal-jejunal bypass on nonalcoholic steatohepatitis, with respect to the gut-liver axis, using a rat model. METHODS: Nonalcoholic steatohepatitis model rats were randomly assigned into 3 groups as follows: 1 sham group and 2 duodenal-jejunal bypass groups. The 2 duodenal-jejunal bypass groups were defined according to the bilio-pancreatic limb length: 30 cm (30-DJB group) and 0 cm (0-DJB group). Pathology findings and blood biochemistry, inflammatory cytokine and lipopolysaccharides receptor mRNA in the liver and common channel, and lipopolysaccharide-binding protein level in the portal vein were assessed. RESULTS: The reduction in plasma alanine aminotransferase and nonalcoholic fatty liver disease activity score in the 30-DJB group was not observed in the 0-DJB group, similar to the sham group. In the liver tissue, mRNA of inflammatory cytokines and lipopolysaccharide receptors, the area occupied by CD68-positive macrophages, and the number of CD3-positive T-lymphocytes on immunostaining were lower in the 30-DJB group; however, these findings were not observed in the 0-DJB group, and lipopolysaccharide-binding protein levels in the portal vein and mRNA expressions of inflammation-related genes in the common channel showed similar tendencies. CONCLUSION: The bilio-pancreatic limb plays an important role in the beneficial effect of duodenal-jejunal bypass for nonalcoholic steatohepatitis. The bilio-pancreatic limb may suppress lipopolysaccharides-related cascades in the liver by reducing intestinal inflammation.

  509. Prognostic value of an inflammation-based nutritional score for patients with initially unresectable pancreatic adenocarcinoma undergoing conversion surgery following chemo-/radiotherapy

    Takashi Kokumai, Shuichi Aoki, Masamichi Mizuma, Shimpei Maeda, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Takashi Kamei, Michiaki Unno

    Surgery Today　51　(10)　1682-1693　2021/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00595-021-02279-5 　

    ISSN： 0941-1291

    eISSN： 1436-2813

  510. Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression. International-journal

    Tomoaki Hirashima, Hideaki Karasawa, Takashi Aizawa, Takashi Suzuki, Akihiro Yamamura, Hideyuki Suzuki, Taiki Kajiwara, Hiroaki Musha, Ryo Funayama, Matsuyuki Shirota, Shinobu Ohnuma, Keiko Nakayama, Michiaki Unno

    Biochemical and biophysical research communications　568　37-42　2021/09/03

    DOI： 10.1016/j.bbrc.2021.06.062 　

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    Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment and have been shown to promote cancer aggressiveness. In our previous study, analysis of expression profiles obtained from paired CAFs and normal fibroblasts from colorectal cancer (CRC) tissue revealed that gene sets related to the Wnt signaling pathway were highly enriched in colorectal CAFs. Furthermore, among the components of the β-catenin-independent Wnt pathway, Wnt5a was highly expressed in CAFs. Since Wnt5a is considered to be a regulator of CRC progression in CAFs, we performed immunohistochemical analysis on Wnt5a in 171 patients who underwent surgery for CRC. Positive staining for Wnt5a was often found in cancer stroma, particularly in fibromatous areas, although the immunoreactivity for Wnt5a was weak in cancer cells. Wnt5a status in CAFs was significantly associated with tumor size, depth of invasion, lymphatic and vascular invasion, lymph node metastasis, TNM stage, and recurrence. Subsequent in vitro analyses using human recombinant Wnt5a protein revealed that cancer cell proliferation and migration were significantly increased by stimulation with Wnt5a. Our findings suggest that Wnt5a-derived CAFs play a crucial role in CRC progression and have potential as a target of anti-cancer therapies.

  511. 大腸癌同所移植モデルにおける癌関連繊維芽細胞のWnt2発現はリンパ節転移と関連する

    唐澤 秀明, 三浦 康, 佐々木 宏之, 小林 実, 梶原 大輝, 亀井 尚, 大沼 忍, 海野 倫明

    日本癌学会総会記事　80回　[P10-4]　2021/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  512. 肝細胞癌に対する開腹肝切除における術前栄養評価としてのControlling nutritional status(CONUT)値の意義

    藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 斎藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    外科と代謝・栄養　55　(4)　109-109　2021/09

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  513. 胃がん多段階発癌モデルの確立

    堂地 大輔, 山村 明寛, 松尾 純一, 志村 充広, 大沼 忍, 亀井 尚, 海野 倫明, 伊藤 嘉明

    日本癌学会総会記事　80回　[E2-2]　2021/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  514. 高齢患者に対する栄養・運動介入法とそのアウトカム 高齢者に対する腹腔鏡下肝切除術における手術リスク評価についての検討

    岡田 薫, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    外科と代謝・栄養　55　(4)　69-69　2021/09

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  515. 侵襲時の生体反応の制御〜その理論と実践〜 肝細胞癌に対する腹腔鏡下肝切除術における硬膜外麻酔の周術期管理に及ぼす影響に関する検討

    西牧 宏泰, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    外科と代謝・栄養　55　(4)　89-89　2021/09

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  516. 胃がん多段階発癌モデルの確立

    堂地 大輔, 山村 明寛, 松尾 純一, 志村 充広, 大沼 忍, 亀井 尚, 海野 倫明, 伊藤 嘉明

    日本癌学会総会記事　80回　[E2-2]　2021/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  517. 当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

    佐々木 健吾, 金井 哲史, 齋藤 純健, 松村 宗幸, 宮澤 恒持, 柏舘 俊明, 藤尾 淳, 戸子台 和哲, 宮城 重人, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　O2-1　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  518. 移植後EBウイルス感染症 当院における生体肝移植後リンパ増殖性疾患 成人および小児症例の解析

    松村 宗幸, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 斎藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    移植　56　(総会臨時)　CWS2-4　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  519. 移植外科医・コーディネーターの働き方改革(互助制度を視野に入れて) 東北大学における脳死臓器摘出互助化の推進と摘出手技教育プログラムの構築 肝膵腎小腸の摘出チームにおける試み

    宮澤 恒持, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　CSY2-5　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  520. 生体肝ドナーの安全性向上(腹腔鏡下手術の適応も含む) 当科の生体肝移植ドナーへの安全性と低侵襲性への取り組み

    藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 斎藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    移植　56　(総会臨時)　SSY6-3　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  521. 悪性腫瘍に対する生体肝移植-肝細胞癌に対する適応拡大、肝門部領域胆管癌、転移性肝癌 局所進行肝門部領域胆管癌に対する肝移植適応の検討

    宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　SWS5-1　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  522. 当院における血液型不適合肝移植の現状

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　P2-9　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  523. 肝移植における慢性抗体関連拒絶の意義と治療介入の試み

    戸子台 和哲, 宮城 重人, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　56　(総会臨時)　P2-10　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  524. 生体移植における家族ケア 生体肝移植におけるドナーケア

    宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　CWS7-4　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  525. 肝移植後長期経過症例における血清Mac-2結合蛋白蛋白糖鎖修飾異性体濃度と移植肝線維化の関連に関する検討

    戸子台 和哲, 宮城 重人, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 亀井 尚, 海野 倫明

    肝臓　62　(Suppl.2)　A537-A537　2021/09

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  526. 吸入麻酔薬、イソフルランによる肝細胞移植グラフト生着促進効果に関する検討

    西牧 宏泰, 齋藤 純健, 稲垣 明子, 中村 保宏, 山名 浩樹, 猪村 武弘, 大橋 一夫, 宮城 重人, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　56　(総会臨時)　O4-2　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  527. 不織布構造ゼラチン基材の導入による皮下膵島移植法の確立

    金井 哲史, 稲垣 明子, 中村 保宏, 猪村 武弘, Fathi Ibrahim, 三頭 啓明, 齋藤 竜助, 宮城 重人, 亀井 尚, 海野 倫明, 田畑 泰彦, 後藤 昌史

    移植　56　(総会臨時)　P2-21　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  528. IBD診療における内科と外科の連携 クローン病の再手術リスク因子を基にした術後早期の生物学的製剤投与の至適症例群の検討(続報)

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 田中 直樹, 山村 明寛, 井本 博文, 土屋 堯裕, 杉沢 徳彦, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　74　(9)　A63-A63　2021/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  529. IBD発癌の諸問題・基礎〜臨床まで インドール化合物による炎症性発癌抑制メカニズムの解明

    大沼 忍, 金原 圭吾, 唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 田山 穂高, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 山村 明寛, 田中 直樹, 森川 孝則, 亀井 尚, 阿部 高明, 海野 倫明

    日本大腸肛門病学会雑誌　74　(9)　A80-A80　2021/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  530. 高齢化するIBDの外科治療 高齢潰瘍性大腸炎患者に対する外科治療成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 亀井 尚, 大沼 忍, 海野 倫明

    日本大腸肛門病学会雑誌　74　(9)　A91-A91　2021/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  531. 大腸T1癌治療後の再発症例の検討

    小林 実, 大沼 忍, 市川 英孝, 杉沢 徳彦, 土屋 堯裕, 梶原 大輝, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 森川 孝則, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　74　(9)　A101-A101　2021/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  532. 当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

    佐々木 健吾, 金井 哲史, 齋藤 純健, 松村 宗幸, 宮澤 恒持, 柏舘 俊明, 藤尾 淳, 戸子台 和哲, 宮城 重人, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　O2-1　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  533. 吸入麻酔薬、イソフルランによる肝細胞移植グラフト生着促進効果に関する検討

    西牧 宏泰, 齋藤 純健, 稲垣 明子, 中村 保宏, 山名 浩樹, 猪村 武弘, 大橋 一夫, 宮城 重人, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　56　(総会臨時)　O4-2　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  534. 移植外科医・コーディネーターの働き方改革(互助制度を視野に入れて) 東北大学における脳死臓器摘出互助化の推進と摘出手技教育プログラムの構築 肝膵腎小腸の摘出チームにおける試み

    宮澤 恒持, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 藤尾 淳, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　CSY2-5　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  535. 悪性腫瘍に対する生体肝移植-肝細胞癌に対する適応拡大、肝門部領域胆管癌、転移性肝癌 局所進行肝門部領域胆管癌に対する肝移植適応の検討

    宮城 重人, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　SWS5-1　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  536. 当院における血液型不適合肝移植の現状

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 藤尾 淳, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 亀井 尚, 海野 倫明

    移植　56　(総会臨時)　P2-9　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  537. 肝移植における慢性抗体関連拒絶の意義と治療介入の試み

    戸子台 和哲, 宮城 重人, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　56　(総会臨時)　P2-10　2021/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  538. 高齢患者に対する栄養・運動介入法とそのアウトカム 高齢者に対する腹腔鏡下肝切除術における手術リスク評価についての検討

    岡田 薫, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    外科と代謝・栄養　55　(4)　69-69　2021/09

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  539. 侵襲時の生体反応の制御〜その理論と実践〜 肝細胞癌に対する腹腔鏡下肝切除術における硬膜外麻酔の周術期管理に及ぼす影響に関する検討

    西牧 宏泰, 藤尾 淳, 宮城 重人, 戸子台 和哲, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 松村 宗幸, 齋藤 純健, 金井 哲史, 海野 倫明, 亀井 尚

    外科と代謝・栄養　55　(4)　89-89　2021/09

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  540. Acinar Cell Carcinoma with Morphological Change in One Month.

    Mio Ikeda, Shin Miura, Shin Hamada, Takanori Sano, Ryotaro Matsumoto, Yu Tanaka, Seiji Hongo, Naoki Yoshida, Tetsuya Takikawa, Kazuhiro Kikuta, Kiyoshi Kume, Tatsuo Hata, Michiaki Unno, Yuko Omori, Toru Furukawa, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　60　(17)　2799-2806　2021/09/01

    DOI： 10.2169/internalmedicine.7121-21 　

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    A 64-year-old man was admitted to our hospital to undergo examination of a pancreatic tumor accompanied by sudden epigastric pain. The tumor had a well-defined oval shape that was mostly less enhanced, with the exception of part of the tumor on the pancreatic head side, on contrast enhanced (CE)-CT. However, CE-CT performed one-month later revealed that the viable part of the tumor grew toward the pancreatic tail with the reduction of necrotic tissue. We performed distal pancreatectomy and the tumor was diagnosed as acinar cell carcinoma (ACC). One important characteristic of ACC is that it may develop morphological changes within a short period of time.

  541. Characteristics of esophageal achalasia in geriatric patients over 75 years of age and outcomes after peroral endoscopic myotomy.

    Naoto Ujiie, Chiaki Sato, Yusuke Taniyama, Ken Koseki, Kai Takaya, Hiroshi Okamoto, Toshiaki Fukutomi, Michiaki Unno, Takashi Kamei

    Geriatrics & gerontology international　21　(9)　788-793　2021/09

    DOI： 10.1111/ggi.14235 　

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    AIM: As the population ages, the proportion aged ≥75 years is expected to increase. Many studies on peroral endoscopic myotomy (POEM) as treatment for esophageal achalasia have already been reported; however, few studies have been designed on patients aged ≥75 years. The purpose of this study is to describe the characteristics of esophageal achalasia in patients >75 years and to evaluate the outcomes of POEM. METHODS: This study included 121 patients who underwent POEM for esophageal achalasia, which was divided into the geriatric (n = 18) group aged ≥75 and the young (n = 103) group ≤74 years. The characteristics of esophageal achalasia and the short-term outcomes after POEM in the geriatric group compared with the young group were retrospectively investigated. RESULTS: The median age of the geriatric group was 78 years, and two patients were initially diagnosed with refractory pneumonia, and esophageal achalasia was initially overlooked. The preoperative Eckardt score of the geriatric group was significantly lower than that of the young group (4 vs. 6, P = 0.007), particularly in the regurgitation score. The Eckardt score and integrated relaxation pressure of both groups were significantly improved after POEM (P < 0.001). There were no cases of perioperative complications in the geriatric group. CONCLUSIONS: POEM for esophageal achalasia is a safe and effective treatment even in geriatric patients >75 years of age. In geriatric patients with recurrent or intractable pneumonia, it is important to rule out esophageal achalasia. Geriatr Gerontol Int 2021; 21: 788-793.

  542. Thoracoscopic esophagectomy for esophageal carcinoma after peroral endoscopic myotomy for esophageal achalasia: a case report. International-journal

    Junichi Tsunokake, Yusuke Taniyama, Fumiyoshi Fujishima, Chiaki Sato, Hiroshi Okamoto, Toshiaki Fukutomi, Yohei Ozawa, Naoto Ujiie, Ken Koseki, Yusuke Gokon, Makoto Horiuchi, Ryujiro Akaishi, Takuro Yamauchi, Michiaki Unno, Takashi Kamei

    Surgical case reports　7　(1)　186-186　2021/08/19

    DOI： 10.1186/s40792-021-01270-z 　

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    BACKGROUND: Esophageal achalasia causes dysphagia following impaired relaxation of the lower esophageal sphincter due to the degeneration of Auerbach's plexus in the esophageal smooth muscle. Recently, peroral endoscopic myotomy (POEM) has become one of the preferred treatment options for esophageal achalasia. However, pathomorphological changes after POEM have not been well examined. CASE PRESENTATION: A 65-year-old man with a history of POEM for esophageal achalasia was diagnosed with clinical stage II (cT2-N0-M0) thoracic esophageal squamous cell carcinoma and was consequently treated with neoadjuvant chemotherapy followed by thoracoscopic esophagectomy. Intraoperatively, the esophagus appeared dilated, reflecting esophageal achalasia; however, fairly slight fibrous adhesions were observed between the esophagus and the pericardial surface despite previously performed POEM via an anterior incision. Histopathological examination revealed esophageal wall thickening, edema, and fibrosis extending from the lamina propria to the submucosa. Besides, the majority of the inner layer and some proportion of the outer layer of the muscularis propria were found to be missing or atrophic at the esophagogastric junction (EGJ). No ganglion cells could be detected at the Auerbach's plexus. CONCLUSIONS: The previous history of POEM did not affect circumferential mediastinal periesophageal dissection during thoracoscopic esophagectomy. Nevertheless, a large proportion of the inner layer of the muscularis propria at the EGJ level seemed to have become lost or atrophic because of the POEM procedure.

  543. Induction of gastric cancer by successive oncogenic activation in the corpus. International-journal

    Daisuke Douchi, Akihiro Yamamura, Junichi Matsuo, Yi Hui Melissa Lim, Napat Nuttonmanit, Mitsuhiro Shimura, Kazuto Suda, Sabirah Chen, Pang ShuChin, Kazuyoshi Kohu, Takaya Abe, Go Shioi, Guowei Kim, Asim Shabbir, Supriya Srivastava, Michiaki Unno, Jimmy Bok-Yan So, Ming Teh, Khay Guan Yeoh, Linda Shyue Huey Chuang, Yoshiaki Ito

    Gastroenterology　2021/08/12

    DOI： 10.1053/j.gastro.2021.08.013 　

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    BACKGROUND & AIMS: Metaplasia and dysplasia in the corpus are reportedly derived from dedifferentiation of chief cells. However, the cellular origin of metaplasia and cancer remained uncertain. Therefore, we investigated whether pepsinogen C-transcript expressing cells (PGC-transcript expressing cells) represent the cellular origin of metaplasia and cancer using a novel Pgc-specific CreERT2 recombinase mouse model. METHODS: We generated a Pgc-mCherry-IRES-CreERT2 (Pgc-CreERT2) knock-in mouse model. Pgc-CreERT2/+ and Rosa-EYFP mice were crossed to generate Pgc-CreERT2/Rosa-EYFP (Pgc-CreERT2/YFP) mice. Gastric tissues were collected, followed by lineage-tracing experiments, histological and immunofluorescence staining. We further established Pgc-CreERT2;KrasG12D/+ mice and investigated whether PGC-transcript expressing cells are responsible for the precancerous state in gastric glands. To investigate cancer development from PGC-transcript expressing cells with activated Kras, inactivated Apc and Trp53 signaling pathways, we crossed Pgc-CreERT2/+ mice with conditional KrasG12D, Apcflox, Trp53flox mice. RESULTS: Expectedly, mCherry mainly labeled chief cells in the Pgc-CreERT2 mice. However, mCherry was also detected throughout the neck cell and isthmal stem/progenitor regions, albeit at lower levels. In the Pgc-CreERT2;KrasG12D/+ mice, PGC-transcript expressing cells with KrasG12D/+ mutation presented pseudopyloric metaplasia. The early induction of proliferation at the isthmus may reflect the ability of isthmal progenitors to react rapidly to Pgc-driven KrasG12D/+ oncogenic mutation. Furthermore, Pgc-CreERT2;KrasG12D/+;Apcflox/flox mice presented intramucosal dysplasia/carcinoma, while Pgc-CreERT2;KrasG12D/+;Apcflox/flox;Trp53flox/flox mice presented invasive and metastatic gastric carcinoma. CONCLUSIONS: The Pgc-CreERT2 knock-in mouse is an invaluable tool to study the effects of successive oncogenic activation in the mouse corpus. Time-course observations can be made regarding the responses of isthmal and chief cells to oncogenic insults. We can observe stomach-specific tumorigenesis from the beginning to metastatic development.

  544. Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer. International-journal

    Yasushi Mochizuki, Ryo Funayama, Matsuyuki Shirota, Yuna Kikukawa, Masahiro Ohira, Hideaki Karasawa, Minoru Kobayashi, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama

    International journal of cancer　149　(10)　1787-1800　2021/08/04

    DOI： 10.1002/ijc.33758 　

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    The splicing of microexons (very small exons) is frequently dysregulated in the brain of individuals with autism spectrum disorder. However, little is known of the patterns, regulatory mechanisms, and roles of microexon splicing in cancer. We here examined the transcriptome-wide profile of microexon splicing in matched colorectal cancer (CRC) and normal tissue specimens. Out of 1492 microexons comprising 3 to 15 nucleotides, 21 (1%) manifested differential splicing between CRC and normal tissue. The 21 genes harboring the differentially spliced microexons were enriched in gene ontology terms related to cell adhesion and migration. RNA interference-mediated knockdown experiments identified two splicing factors, RBFOX2 and PTBP1, as regulators of microexon splicing in CRC cells. RBFOX2 and PTBP1 were found to directly bind to microexon-containing pre-mRNAs and to control their splicing in such cells. Differential microexon splicing was shown to be due, at least in part, to altered expression of RBFOX2 and PTBP1 in CRC tissue compared with matched normal tissue. Finally, we found that changes in the pattern of microexon splicing were associated with CRC metastasis. Our data thus suggest that altered expression of RBFOX2 and PTBP1 might influence CRC metastasis through the regulation of microexon splicing.

  545. 膵神経内分泌腫瘍に対する外科的切除症例に関する後ろ向き研究

    肱岡 範, 伊藤 鉄英, 山上 裕機, 海野 倫明, 中村 雅史, 土井 隆一郎, 青木 琢, 大塚 隆生, 森實 千種, 古瀬 純司, 奥坂 拓志

    膵臓　36　(3)　A116-A116　2021/08

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  546. 腹腔鏡下胆道拡張症手術 膵・胆管合流異常成人例に対する腹腔鏡下肝外胆管切除・胆道再建術

    森川 孝則, 石田 晶玄, 三浦 孝之, 千葉 和治, 青木 修一, 堂地 大輔, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 水間 正道, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　44　70-70　2021/08

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  547. 術前診断が困難であった、妊娠中に発症した胆道癌合併先天性胆道拡張症の1例

    林 秀一郎, 大塚 英郎, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　44　98-99　2021/08

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  548. 本邦における膵臓移植・膵島移植の位置づけ 当院における膵臓移植・膵島移植の位置づけ

    宮城 重人, 後藤 昌史, 戸子台 和哲, 藤尾 淳, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 亀井 尚, 海野 倫明

    膵臓　36　(3)　A269-A269　2021/08

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  549. ABO-incompatible living donor liver transplantation with high preoperative antibody titer: A case report. International-journal

    Yoshikatsu Saitoh, Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Michiaki Unno, Takashi Kamei

    International journal of surgery case reports　85　106260-106260　2021/08

    DOI： 10.1016/j.ijscr.2021.106260 　

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    INTRODUCTION AND IMPORTANCE: ABO-incompatible living donor liver transplantation (ABOi-LDLT) is essential for expanding the donor pool. ABOi-LDLT prognosis has improved since desensitization treatment with rituximab; however, patients with high antibody titers are considered to be at high risk of antibody mediated rejection (AMR). Nevertheless, the preoperative antibody titer cutoff levels that preclude ABOi-LDLT have not yet been determined. In this study, the highest preoperative antibody titer was 1:4096, and the recipient had good outcomes. There has been only one report of good outcomes with a preoperative antibody titer of more than 1:4096. We hypothesized that high preoperative antibody titers in ABOi-LDLT may not be associated with AMR in protocols involving rituximab. CASE PRESENTATION: The recipient was a 22-year-old man with biliary atresia and underwent ABOi-LDLT (B to O). We administered 500 mg of rituximab 14 days prior and then 300 mg of rituximab one day prior to ABOi-LDLT. The recipients preoperative IgG antibody titer was 1:4096. Postoperative immunosuppressive protocol involved steroids, tacrolimus, and mycophenolate mofetil. The patient had satisfactory graft function three years following ABOi-LDLT. CLINICAL DISCUSSION: The antibody that is responsible for posttransplant AMR should be newly synthesized after transplantation as a result of sensitization by antigens on the vascular endothelial cells of the graft. In ABOi-LDLT, natural antibodies may not cause AMR. CONCLUSIONS: The most important factor for preventing AMR in recipients undergoing ABOi-LDLT is the suppression of de novo antibodies. High preoperative antibody titers may not necessarily preclude ABOi-LDLT, provided that rituximab is used in desensitization.

  550. 膵癌治療のパラダイムシフトに向けた展望 腹腔洗浄細胞診陽性膵癌に対する治療戦略

    水間 正道, 有明 恭平, 高舘 達之, 青木 修一, 三浦 孝之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 粂 潔, 正宗 淳, 亀井 尚, 海野 倫明

    膵臓　36　(3)　A166-A166　2021/08

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  551. 切除可能膵癌に対する周術期治療の現状と問題点 切除可能膵癌に対する新たな術前治療法および術前治療回避可能性の検討

    森川 孝則, 水間 正道, 千葉 和治, 青木 修一, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 粂 潔, 亀井 尚, 正宗 淳, 海野 倫明

    膵臓　36　(3)　A180-A180　2021/08

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  552. Circulating tumor DNA as a predictive marker for occult metastases in pancreatic cancer patients with radiographically non-metastatic disease.

    Tatsuo Hata, Masamichi Mizuma, Masahiro Iseki, Tatsuyuki Takadate, Masaharu Ishida, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　28　(8)　648-658　2021/08

    DOI： 10.1002/jhbp.993 　

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    PURPOSE: To elucidate the effectiveness of circulating tumor DNA (ctDNA) for predicting occult metastases in patients with pancreatic cancer without apparent metastases. METHODS: Circulating tumor DNA was obtained from plasma samples of 165 patients with pancreatic cancer and analyzed using droplet digital PCR. The prevalence and allele frequencies of ctDNA were compared across different patterns and degrees of metastatic spread. RESULTS: Of the 142 patients without apparent metastases who underwent abdominal exploration, 39 (27.5%) harbored occult metastases including positive peritoneal lavage cytology. The prevalence of ctDNA was significantly higher in patients with occult metastases than in those without (41.0% vs 14.6%, P = .001). A markedly high prevalence of ctDNA was observed in patients with radiographically visible metastases (78.3%). ctDNA was found to be an independent predictor of the presence of occult metastases (odds ratio: 3.113, P = .039), and its diagnostic performance in combination with tumor markers had a sensitivity of 66.7% and a specificity of 81.6%. In 62 treatment-naïve patients without metastases, multivariate analysis identified the presence of ctDNA as an independent prognostic factor (hazard ratio: 6.311, P = .001). CONCLUSION: Circulating tumor DNA can help predict the presence of occult metastases in pancreatic cancer patients with radiographically non-metastatic disease.

  553. A rare case of penetration related to ischemic duodenitis after ventricular assist device implantation for dilated cardiomyopathy.

    Hiroko Abe, Kaname Uno, Naoki Tanaka, Masamichi Mizuma, Waku Hatta, Naoki Asano, Tomoyuki Koike, Akira Imatani, Michiaki Unno, Atsushi Masamune

    Clinical journal of gastroenterology　14　(4)　1186-1190　2021/08

    DOI： 10.1007/s12328-021-01346-1 　

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    A 66-year-old man with a history of diabetes and dilated cardiomyopathy underwent the implantation of a ventricular assist device (VAD) at the age of 62. He suffered from epigastralgia for a month and then visited our hospital with complaints of severe epigastralgia and hematemesis. A physical examination revealed abdominal distension without rigidity. Laboratory data showed severe systemic inflammation, multiple organ failure, and disseminated intravascular coagulation. Computed tomography showed multifocal thickness of the gastroduodenal wall with surrounding panniculitis, gas in a portal vein and a perigastric vein. Emergency esophago-gastro duodenoscopy (EGD) demonstrated a large erosion in the antrum of the stomach, and penetration surrounded by circumferentially ischemic mucosa in the second and third portions of the duodenum. Based on informed consent, conservative therapy was performed, and his condition improved enabling the start of oral intake on the 37th hospital day. However, 7 days later, there was a relapse of epigastralgia after a meal. Gastrointestinal series and EGD revealed a 10-mm-long pinhole-like stricture at the site. After laparoscopic gastro-jejunal bypass surgery, he has remained in a good condition for 2 years. We demonstrated a rare case of penetration due to severe ischemic duodenitis 4 years after VAD implantation.

  554. 術前systemic inflammatory statusが膵癌conversion surgery術後の予後に与える影響

    青木 修一, 水間 正道, 國米 崇, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　76回　P223-4　2021/07

    Publisher: (一社)日本消化器外科学会

  555. ラット過小グラフト肝移植モデルに対するヒトMuse細胞静脈投与による肝類洞微小循環改善効果について

    菖野 佳浩, 串田 良祐, 黒田 康勝, 若尾 昌平, 海野 倫明, 亀井 尚, 宮城 重人, 出澤 真理

    日本消化器外科学会総会　76回　P143-3　2021/07

    Publisher: (一社)日本消化器外科学会

  556. 当科におけるGroove膵癌の臨床的特徴

    林 秀一郎, 石田 晶玄, 千葉 和治, 青木 修一, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 有明 恭平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 粂 潔, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　211回　56-56　2021/07

    Publisher: 日本消化器病学会-東北支部

  557. 多施設臨床研究国内第一例目となる、酸素化灌流保存装置を使用した心停止ドナー腎移植の報告

    宮城 重人, 柏舘 俊明, 西牧 宏泰, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 亀井 尚, 海野 倫明, 松野 直徒

    移植　56　(1)　69-74　2021/07

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  558. 十二指腸乳頭の形態異常を伴い膵・胆管合流異常類似の病態を呈した1例

    片岡 史弥, 三浦 晋, 粂 潔, 菊田 和宏, 濱田 晋, 滝川 哲也, 吉田 直樹, 松本 諒太郎, 田中 裕, 池田 未緒, 佐々木 滉, 三浦 孝之, 海野 倫明, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　211回　55-55　2021/07

    Publisher: 日本消化器病学会-東北支部

  559. イソフランが肝細胞移植においてグラフト生着へ及ぼす影響に関する検討

    西牧 宏泰, 齋藤 純健, 稲垣 明子, 中村 保宏, 山名 浩樹, 猪村 武弘, 大橋 一夫, 宮城 重人, 亀井 尚, 海野 倫明, 後藤 昌史

    日本組織移植学会雑誌　19　(1)　66-66　2021/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  560. ヒト羊膜のラット虚血性潰瘍モデルに対する創傷治癒効果の検討

    佐藤 将人, 戸子台 和哲, 田中 美也子, 小笠原 弘之, 菅原 宏文, 齋藤 昌利, 星合 哲郎, 宮城 重人, 海野 倫明, 後藤 昌史, 亀井 尚

    日本組織移植学会雑誌　19　(1)　39-39　2021/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  561. ラットに対する経門脈的ヒト羊膜上皮細胞移植後の細胞分布および分化生着の検討

    田中 美也子, 戸子台 和哲, 佐藤 将人, 齋藤 昌利, 星合 哲郎, 宮城 重人, 三木 敏生, 海野 倫明, 亀井 尚, 後藤 昌史

    日本組織移植学会雑誌　19　(1)　40-40　2021/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  562. ヒト羊膜上皮細胞を用いた食道ESD後潰瘍瘢痕狭窄予防法の開発に関する研究

    今野 裕司, 佐藤 千晃, 戸子台 和哲, 齋藤 昌利, 星合 哲郎, 岡本 宏史, 福富 俊明, 谷山 裕亮, 海野 倫明, 亀井 尚

    日本組織移植学会雑誌　19　(1)　41-41　2021/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  563. 抗利尿ホルモン不適切分泌症候群を合併した潰瘍性大腸炎の1手術例

    陳 梦格, 神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 小林 実, 市川 英孝, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　211回　61-61　2021/07

    Publisher: 日本消化器病学会-東北支部

  564. 高齢者に対する腹腔鏡下肝切除の検討

    齋藤 純健, 藤尾 淳, 宮城 重人, 戸子台 和哲, 中西 渉, 柏舘 俊明, 宮澤 恒持, 佐々木 健吾, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　P163-6　2021/07

    Publisher: (一社)日本消化器外科学会

  565. 手術手技 dCRT後局所進行食道癌に対する胸腔鏡下サルベージ食道切除の際に留意すべき気管・気管支周囲の剥離操作のポイントと血流保持の工夫

    福富 俊明, 谷山 裕亮, 八嶋 嘉之, 岡本 宏史, 海野 倫明, 亀井 尚

    手術　75　(8)　1319-1328　2021/07

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  566. Cadaverトレーニングの現状と課題 安全な胸腔鏡下食道切除術施行を目指した実践的Cadaverトレーニング

    堀内 真, 岡本 宏史, 郷右近 祐介, 氏家 直人, 小澤 洋平, 福富 俊明, 佐藤 千晃, 谷山 裕亮, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　O7-5　2021/07

    Publisher: (一社)日本消化器外科学会

  567. 食道アカラシアに対する治療戦略と術後QOL 当科における食道運動障害の診断と治療成績

    國光 敦, 佐藤 千晃, 氏家 直人, 小澤 洋平, 福富 俊明, 岡本 宏史, 谷山 裕亮, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　RS4-1　2021/07

    Publisher: (一社)日本消化器外科学会

  568. 食道癌扁平上皮癌に対する食道切除後早期のCRP上昇が予後に与える影響

    福富 俊明, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 小澤 洋平, 氏家 直人, 郷右近 祐介, 堀内 真, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　P058-3　2021/07

    Publisher: (一社)日本消化器外科学会

  569. 食道胃接合部癌に対する組織型、壁深達度から見る縦隔リンパ節郭清範囲

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 福富 俊明, 小澤 洋平, 氏家 直人, 小関 健, 郷右近 祐介, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　P094-3　2021/07

    Publisher: (一社)日本消化器外科学会

  570. 局所進行食道癌における予後因子としてのPsoas muscle index(PMI)の意義

    小澤 洋平, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 氏家 直人, 小関 健, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　P227-6　2021/07

    Publisher: (一社)日本消化器外科学会

  571. 傾向スコアを用いたBarrett食道癌と胃噴門部癌の比較

    郷右近 祐介, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 小澤 洋平, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　76回　P287-4　2021/07

    Publisher: (一社)日本消化器外科学会

  572. 局所進行S状結腸癌に対する術前化学療法の有用性

    唐澤 秀明, 初沢 悠人, 小林 実, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　76回　P028-3　2021/07

    Publisher: (一社)日本消化器外科学会

  573. 直腸癌術後排便機能障害に対する工夫 直腸癌術後の排便排尿および性機能障害を評価するスマート問診システムの開発

    梶原 大輝, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 小林 実, 園部 真也, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　76回　WS12-6　2021/07

    Publisher: (一社)日本消化器外科学会

  574. 進行下部直腸癌に対する術前化学放射線療法が術後短期成績に与える影響について

    初沢 悠人, 大沼 忍, 小林 実, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　76回　P052-6　2021/07

    Publisher: (一社)日本消化器外科学会

  575. 大腸全摘術における再建法の選択 潰瘍性大腸炎手術における近年の患者背景と再建法の変化

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　76回　RS8-7　2021/07

    Publisher: (一社)日本消化器外科学会

  576. 術前化学放射線療法後の直腸癌に対するロボット支援下手術の短期治療成績

    大沼 忍, 神山 篤史, 唐澤 秀明, 小林 実, 梶原 大輝, 鈴木 秀幸, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　76回　P122-1　2021/07

    Publisher: (一社)日本消化器外科学会

  577. 在宅中心静脈栄養患者におけるCVカテーテル関連感染症の季節変動に関する検討

    小林 実, 渡辺 和宏, 初沢 悠人, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　76回　P131-1　2021/07

    Publisher: (一社)日本消化器外科学会

  578. クローン病に対するSasaki-W吻合を応用した、萎縮した細径腸管に対するストーマ閉鎖手技

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　76回　P253-5　2021/07

    Publisher: (一社)日本消化器外科学会

  579. IgG4-related Diaphragmatic Inflammatory Pseudotumor.

    Yu Tanaka, Tetsuya Takikawa, Kiyoshi Kume, Kazuhiro Kikuta, Shin Hamada, Shin Miura, Naoki Yoshida, Seiji Hongo, Ryotaro Matsumoto, Takanori Sano, Mio Ikeda, Michiaki Unno, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　60　(13)　2067-2074　2021/07/01

    DOI： 10.2169/internalmedicine.6589-20 　

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    A 71-year-old man underwent surgery for a pancreatic neuroendocrine tumor. Follow-up imaging showed swelling of the remnant pancreas, and he was histologically diagnosed with autoimmune pancreatitis based on endoscopic ultrasonography-guided fine-needle aspiration specimens. After two years, a tumor appeared on the liver surface. Although we planned to perform laparoscopic partial hepatectomy, the intraoperative findings showed that the tumor was located in the diaphragm. Partial resection of the diaphragm was performed, and the final diagnosis was an immunoglobulin G4-related inflammatory pseudotumor in the diaphragm. To our knowledge, this is the first reported case of an immunoglobulin G4-related diaphragmatic inflammatory pseudotumor.

  580. Antimesenteric cutback end-to-end isoperistaltic anastomosis (Sasaki-Watanabe anastomosis) for Crohn's disease: Novel surgical technique and early results of surgical anastomotic recurrence.

    Kazuhiro Watanabe, Iwao Sasaki, Atsushi Kohyama, Hideyuki Suzuki, Minoru Kobayashi, Taiki Kajiwara, Hideaki Karasawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Annals of gastroenterological surgery　5　(4)　528-537　2021/07

    DOI： 10.1002/ags3.12445 　

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    Background: Antimesenteric cutback end-to-end isoperistaltic anastomosis (Sasaki-Watanabe anastomosis; Sasaki-W anastomosis), which was developed in our department, is a novel hand-sewn anastomotic technique for Crohn's disease intended to prevent anastomotic stenosis and preserve the peripheral circulation. Aim: The aim of the present study is to present the surgical technique of Sasaki-W anastomosis and to assess the safety and the early results of the surgical anastomotic recurrence of Sasaki-W anastomosis. Patients and Methods: The present study was a single-center retrospective cohort study. As an early-period group, 13 patients with Crohn's disease, who were mainly selected from cases considered to be at high risk of recurrence, underwent 15 Sasaki-W anastomoses from August 2009 to January 2012. As a late-period group, 36 patients with Crohn's disease, who were selected regardless of risk factors, underwent 37 Sasaki-W anastomoses from September 2016 to March 2020. The medical data including patient characteristics, surgical records, postoperative details, and surgical recurrences were assessed. Results: There were no intraoperative complications. With a median follow-up of 107 mo, surgical recurrence occurred in one patient at 106 mo after surgery in the early-period group. The cumulative surgical recurrence-free rate in the early-period group was 100% at 5 y and 86% at 10 y after surgery. No patients required reoperation in the late-period group. Conclusion: Sasaki-W anastomosis is safe and feasible. Although long-term study is needed, this anastomotic technique can be a reasonable operative option for Crohn's disease.

  581. Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model. International-journal

    Norihiko Sugisawa, Takashi Higuchi, Qinghong Han, Chihiro Hozumi, Jun Yamamoto, Yoshihiko Tashiro, Hiroto Nishino, Kei Kawaguchi, Michael Bouvet, Takuya Murata, Michiaki Unno, Robert M Hoffman

    Cancer chemotherapy and pharmacology　88　(1)　61-67　2021/07

    DOI： 10.1007/s00280-021-04261-x 　

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    PURPOSE: Advanced ovarian clear cell carcinoma (OCCC) is a recalcitrant disease, often resistant to the first-line platinum-based therapy. Using a novel patient-derived orthotopic xenograft (PDOX) nude-mouse model of OCCC, we tested whether oral-recombinant methioninase (o-rMETase) could enhance the efficacy of paclitaxel (PTX). METHODS: The OCCC PDOX model was established and passaged in nude mice. The OCCC PDOX models were randomized into 5 groups. G1: untreated control; G2: paclitaxel (PTX) (20 mg/kg, intraperitoneal (i.p.) injection, weekly); G3: o-rMETase (100 units, oral, daily); G4: PTX (20 mg/kg, i.p. injection, weekly) + carboplatinum (CBDCA) (40 mg/kg, i.p. injection weekly); G5: PTX (20 mg/kg, i.p. injection, weekly) + o-rMETase (100 units, oral, daily). The treatment period was 2 weeks. RESULTS: The combination of PTX and o-rMETase arrested OCCC tumor growth (relative tumor volume: 1.09 ± 0.63 (mean ± SD)) compared with the untreated control (relative tumor volume: 3.92 ± 1.04 (mean ± SD)) (p < 0.0001). There was no significant difference in relative tumor volume between PTX plus o-rMETase and PTX plus CBDCA (relative tumor volume: 1.39 ± 0.37 (mean ± SD)) (p = 0.93). CONCLUSION: PTX plus o-rMETase arrested the OCCC tumor growth. o-rMETase is readily administered and can greatly enhance first-line therapy of a recalcitrant cancer. The novel and effective treatment strategy in the present report has future clinical potential for patients with OCCC, especially for patients who cannot well tolerate platinum-based therapy.

  582. The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer. International-journal

    Hodaka Tayama, Hideaki Karasawa, Akihiro Yamamura, Yasunobu Okamura, Fumiki Katsuoka, Hideyuki Suzuki, Taiki Kajiwara, Minoru Kobayashi, Yuuri Hatsuzawa, Masahiro Shiihara, Li Bin, Md Yeashin Gazi, Mizuki Sato, Kazuki Kumada, Shigehiro Ito, Muneaki Shimada, Toru Furukawa, Takashi Kamei, Shinobu Ohnuma, Michiaki Unno

    Biochemical and biophysical research communications　560　59-65　2021/06/30

    DOI： 10.1016/j.bbrc.2021.04.130 　

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    The mitogen-activated protein kinase (MAPK) pathway plays an important role in the colorectal cancer (CRC) progression, being supposed to be activated by the gene mutations, such as BRAF or KRAS. Although the inhibitors of extracellular signal-regulated kinase (ERK) have demonstrated efficacy in the cells with the BRAF or KRAS mutations, a clinical response is not always associated with the molecular signature. The patient-derived organoids (PDO) have emerged as a powerful in vitro model system to study cancer, and it has been widely applied for the drug screening. The present study aims to analyze the association between the molecular characteristics which analyzed by next-generation sequencing (NGS) and sensitivity to the ERK inhibitor (i.e., SCH772984) in PDO derived from CRC specimens. A drug sensitivity test for the SCH772984 was conducted using 14 CRC cell lines, and the results demonstrated that the sensitivity was in agreement with the BRAF mutation, but was not completely consistent with the KRAS status. In the drug sensitivity test for PDO, 6 out of 7 cases with either BRAF or KRAS mutations showed sensitivity to the SCH772984, while 5 out of 6 cases of both BRAF and KRAS wild-types were resistant. The results of this study suggested that the molecular status of the clinical specimens are likely to represent the sensitivity in the PDOs but is not necessarily absolutely overlapping. PDO might be able to complement the limitations of the gene panel and have the potential to provide a novel precision medicine.

  583. Germline DNA damage repair gene mutations in pancreatic cancer patients with personal/family histories of pancreas/breast/ovarian/prostate cancer in a Japanese population

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Toru Furukawa, Michiaki Unno

    Annals of Gastroenterological Surgery　2021/06/28

    DOI： 10.1002/ags3.12482 　

  584. Living donor liver transplantation for Budd‒Chiari syndrome with right posterior segment graft and patch plasty using the superficial femoral vein: a case report. International-journal

    Norikazu Une, Kazuaki Tokodai, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Atsushi Fujio, Wataru Nakanishi, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Surgical case reports　7　(1)　136-136　2021/06/04

    DOI： 10.1186/s40792-021-01224-5 　

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    BACKGROUND: In living donor liver transplantation (LDLT) for patients with Budd‒Chiari syndrome (BCS), there are several concerns about reconstruction of the inferior vena cava (IVC) and hepatic veins. Herein, we report the case of a patient with BCS who underwent LDLT with right posterior segment graft (RPSG) and patch plasty for reconstruction of the hepatic venous outflow, using the patient's own superficial femoral vein (SFV). CASE PRESENTATION: A 19-year-old man, who was diagnosed with primary BCS, underwent LDLT. His main hepatic veins were totally obstructed, and membranous stenosis was seen in the IVC. The LDLT donor was his mother; however, liver volumetric analysis showed that only her RPSG was appropriate. In the recipient surgery, 16 cm of the left SFV was harvested and was cut longitudinally and opened. The right hepatic vein (RHV) of the RPSG was anastomosed to the sidewall of the SFV graft. After explantation of native diseased liver was completed, the stenotic and thickened wall of the IVC was widely resected, and a large anastomotic orifice was created. Patch cavoplasty was performed with the RHV‒SFV graft patch. After portal reperfusion started, hepatic venous outflow was satisfactory, and there was no venous graft congestion. Both his postoperative course and his long-term course after discharge were uneventful. CONCLUSIONS: In LDLT for BCS patients, ingenuity is required for the reconstruction of venous outflow. The SFV patch can be safely harvested from liver transplant recipients and is suitable for venous reconstruction. In addition, RPSG is an alternative type of liver graft for LDLT if a conventional right- or left-lobe graft cannot be used.

  585. Survey of surgical resections for neuroendocrine liver metastases: A project study of the Japan Neuroendocrine Tumor Society (JNETS).

    Taku Aoki, Keiichi Kubota, Sho Kiritani, Junichi Arita, Chigusa Morizane, Toshihiko Masui, Atsushi Kudo, Izumi Komoto, Etsuro Hatano, Tetsuhide Ito, Robert Y Osamura, Michiaki Unno, Shinji Uemoto, Norihiro Kokudo

    Journal of hepato-biliary-pancreatic sciences　28　(6)　489-497　2021/06

    DOI： 10.1002/jhbp.956 　

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    BACKGROUND/PURPOSE: Hepatic resection is considered the treatment of choice for neuroendocrine liver metastases (NELM). However, the safety and efficacy of resection have not been fully evaluated using a large cohort. The aim of the present study was to collect real-world data regarding hepatic resections for NELM. METHODS: A retrospective, multicenter survey was conducted. The background characteristics of patients undergoing an initial hepatic resection for NELM, the operative details, pathological findings, and patient outcomes were investigated. RESULTS: A total of 222 patients were enrolled from 30 institutions. The primary tumor site was the pancreas in 58.6%, and the presentation of NELM was synchronous in 63.1% of the cases. Concomitant resection of the primary tumor and liver metastases was performed for 66.4% of the synchronous metastases, and the 90-day morbidity and mortality rates were 12.6% and 0.9%, respectively. The operations resulted in R2 resections in 26.1% of the cases, and 83.4% of the patients experienced recurrence after R0/1 resections. However, the patients were treated using multiple modalities after R2 resection or recurrence, and the overall survival rate was relatively favorable, with 5-year and 10-year survival rates of 70.2%, and 43.4%, respectively. Univariable and multivariable analyses identified the tumor grading (G3) of the primary tumor as a significant prognostic factor for both the recurrence-free and overall survivals. CONCLUSIONS: The present data confirmed the safety of the surgical resection of NELM. Although recurrences were frequent, the survival outcomes after resection were favorable when a multi-disciplinary treatment approach was used.

  586. Silencing of LRRFIP1 enhances the sensitivity of gemcitabine in pancreatic cancer cells by activating JNK/c-Jun signaling. International-journal

    Shuhei Kawasaki, Hideo Ohtsuka, Yoshihiro Sato, Daisuke Douchi, Masaki Sato, Kyohei Ariake, Kunihiro Masuda, Koji Fukase, Masamichi Mizuma, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　21　(4)　771-778　2021/06

    DOI： 10.1016/j.pan.2021.02.018 　

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    BACKGROUND: The epithelial-mesenchymal transition (EMT) in cancer cells has been shown to closely associate with the survival and drug resistance of cancer cells. We recently provided evidence that Wnt signal activator leucine-rich repeat in flightless-1-interacting protein 1 (LRRFIP1) regulates EMT in pancreatic cancer. LRRFIP1 silencing inhibits the translocation of β-catenin to the nucleus, which led to reverse EMT in cancer cells. It was suggested that LRRFIP1 was implicated in gemcitabine sensitivity by regulating EMT signaling. METHODS: Gemcitabine chemosensitivity was investigated in LRRFIP1-knockdown pancreatic cancer cells (PANC-1 and MIA Paca-2). In addition, the effects of LRRFIP1 knockdown on JNK/SAPK (stress activated-protein kinase) signaling and apoptosis were evaluated. RESULTS: LRRFIP1 silencing accelerates gemcitabine-induced caspase activity and cell death in pancreatic cancer cells. It was also revealed that gemcitabine-induced phosphorylation of c-Jun N-terminal kinase (JNK) and c-Jun were increased in LRRFIP1 knockdown cells. The activation of JNK/c-Jun in LRRFIP1-knockdown cells was significantly diminished by the inhibition of Rac activity. It was confirmed that the acquisition of gemcitabine sensitivity by LRRFIP1 silencing largely depends on the stimulation of JNK/SAPK (stress activated-protein kinase) signaling. CONCLUSIONS: Our findings suggest that reversing EMT and transient activation of JNK might be essential for the gemcitabine sensitivity in LRRFIP1 knockdown pancreatic cancer cells. Our discoveries highlight the potential role of LRRFIP1 in the chemosensitivity related to the regulation of EMT signaling.

  587. Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer. International-journal

    Dang Chao, Kyohei Ariake, Satoko Sato, Hideo Ohtsuka, Tatsuyuki Takadate, Masaharu Ishida, Kunihiro Masuda, Shimpei Maeda, Takayuki Miura, Katsutaka Mitachi, Xun Jing Yu, Fumiyoshi Fujishima, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Oncology reports　45　(6)　2021/06

    DOI： 10.3892/or.2021.8041 　

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    Stomatin‑like protein 2 (SLP‑2) is associated with poor prognosis in several types of cancer, including pancreatic cancer (PC); however, the molecular mechanism of its involvement remains elusive. The present study aimed to elucidate the role of this protein in the development of PC. Human PC cell lines AsPC‑1 and PANC‑1 were transfected by a vector expressing SLP‑2 shRNA. Analyses of cell proliferation, migration, invasion, chemosensitivity, and glucose uptake were conducted, while a mouse xenograft model was used to evaluate the functional role of SLP‑2 in PC. Immunohistochemical analysis was retrospectively performed on human tissue samples to compare expression between the primary site (n=279) and the liver metastatic site (n=22). Furthermore, microarray analysis was conducted to identify the genes correlated with SLP‑2. In vitro analysis demonstrated that cells in which SLP‑2 was suppressed exhibited reduced cell motility and glucose uptake, while in vivo analysis revealed a marked decrease in the number of liver metastases. Immunohistochemistry revealed that SLP‑2 was increased in liver metastatic sites. Microarray analysis indicated that this protein regulated the expression of glutamine‑fructose‑6‑phosphate transaminase 2 (GFPT2), a rate‑limiting enzyme of the hexosamine biosynthesis pathway. SLP‑2 contributed to the malignant character of PC by inducing liver metastasis. Cell motility and glucose uptake may be induced via the hexosamine biosynthesis pathway through the expression of GFPT2. The present study revealed a new mechanism of liver metastasis and indicated that SLP‑2 and its downstream pathway could provide novel therapeutic targets for PC.

  588. The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors

    Norikazu Une, Mayumi Takano-Kasuya, Narufumi Kitamura, Mineto Ohta, Tomoya Inose, Chihiro Kato, Ryuichi Nishimura, Hiroshi Tada, Shigehito Miyagi, Takanori Ishida, Michiaki Unno, Takashi Kamei, Kohsuke Gonda

    Medical Oncology　38　(6)　2021/06

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12032-021-01503-z 　

    ISSN： 1357-0560

    eISSN： 1559-131X

  589. Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma. International-journal

    Shingo Yoshimachi, Ryutaro Shirakawa, Mingxin Cao, Duc Anh Trinh, Pan Gao, Natsumi Sakata, Kento Miyazaki, Kota Goto, Takayuki Miura, Kyohei Ariake, Shimpei Maeda, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Hisanori Horiuchi

    Cancer science　2021/05/19

    DOI： 10.1111/cas.14970 　

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    The small GTPases RalA and RalB are members of the Ras family and activated downstream of Ras. Ral proteins are found in GTP-bound active and GDP-bound inactive forms. The activation process is executed by guanine nucleotide exchange factors, while inactivation is mediated by GTPase-activating proteins (GAPs). RalGAPs are complexes that consist of a catalytic α1 or α2 subunit together with a common β subunit. Several reports implicate the importance of Ral in pancreatic ductal adenocarcinoma (PDAC). However, there are few reports on the relationship between levels of RalGAP expression and malignancy in PDAC. We generated RalGAPβ-deficient PDAC cells by CRISPR-Cas9 genome editing to investigate how increased Ral activity affects malignant phenotypes of PDAC cells. RalGAPβ-deficient PDAC cells exhibited several-fold higher Ral activity relative to control cells. They had a high migratory and invasive capacity. The RalGAPβ-deficient cells grew more rapidly than control cells when injected subcutaneously into nude mice. When injected into the spleen, the RalGAPβ-deficient cells formed larger splenic tumors with more liver metastases, and unlike controls, they disseminated into the abdominal cavity. These results indicate that RalGAPβ deficiency in PDAC cells contributes to high activities of RalA and RalB, leading to enhanced cell migration and invasion in vitro, and tumor growth and metastasis in vivo.

  590. 高齢者におけるStageII大腸癌の治療成績および再発危険因子の検討

    平嶋 倫亮, 梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　74　(5)　335-335　2021/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  591. 【消化器癌;診断と治療のすべて】消化器癌の診断・病期分類・治療・成績 胆管癌(肝門部領域胆管癌・遠位胆管癌・乳頭部癌) 疫学と病期分類

    青木 修一, 中川 圭, 益田 邦洋, 森川 孝則, 海野 倫明

    消化器外科　44　(6)　914-919　2021/05

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  592. 【各施設での胆膵疾患に対する診療科横断的チーム医療】東北大学病院での胆膵疾患に対する診療科横断的チーム医療

    中川 圭, 水間 正道, 大塚 英郎, 益田 邦洋, 石田 晶玄, 森川 孝則, 海野 倫明

    胆と膵　42　(5)　389-392　2021/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  593. 高齢者におけるStageII大腸癌の治療成績および再発危険因子の検討

    平嶋 倫亮, 梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　74　(5)　335-335　2021/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  594. Safety of Combined Division vs Separate Division of the Splenic Vein in Patients Undergoing Distal Pancreatectomy: A Noninferiority Randomized Clinical Trial. International-journal

    Suguru Yamada, Tsutomu Fujii, Fuminori Sonohara, Manabu Kawai, Kazuto Shibuya, Ippei Matsumoto, Kengo Fukuzawa, Hideo Baba, Takeshi Aoki, Michiaki Unno, Sohei Satoi, Yoji Kishi, Etsuro Hatano, Kenichiro Uemura, Akihiko Horiguchi, Masayuki Sho, Yutaka Takeda, Toshio Shimokawa, Yasuhiro Kodera, Hiroki Yamaue

    JAMA surgery　156　(5)　418-428　2021/05/01

    DOI： 10.1001/jamasurg.2021.0108 　

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    Importance: In distal pancreatectomy (DP), the splenic vein is isolated from the pancreatic parenchyma prior to being ligated and divided to prevent intra-abdominal hemorrhage from the splenic vein stump with pancreatic fistula (PF). Conversely, dissecting the splenic vein with the pancreatic parenchyma is easy and time-saving. Objective: To establish the safety of combined division of the splenic vein compared with separate division of the splenic vein. Design, Setting, and Participants: This study was designed as a multicenter prospective randomized phase 3 trial. All results were analyzed using the modified intent-to-treat set. Patients undergoing DP for pancreatic body and tail tumors were eligible for inclusion. Patients were randomly assigned between August 10, 2016, and July 30, 2019. Interventions: Patients were centrally randomized (1:1) to either separate division of the splenic vein or combined division of the splenic vein. Main Outcomes and Measures: The primary end point was the incidence of grade B/C PF, and the incidence of intra-abdominal hemorrhage was included as one of the secondary end points. Results: A total of 318 patients were randomly assigned, and 2 patients were excluded as ineligible. Of the 316 remaining patients, 150 (50.3%) were male. The modified intent-to-treat population constituted 159 patients (50.3%) in the separate division group and 157 patients (49.7%) in the combined division group. In the modified intent-to-treat set, the proportion of grade B/C PF in the separate division group was 27.1% (42 of 155) vs 28.6% (44 of 154) in the combined division group (adjusted odds ratio, 1.108; 95% CI, 0.847-1.225; P = .047), demonstrating noninferiority of the combined division of the splenic vein against separate division. The incidence of postoperative intra-abdominal hemorrhage in the 2 groups was identical at 1.3%. Conclusions and Relevance: This study demonstrated noninferiority of the combined division of the splenic vein compared with separate division of the splenic vein regarding safety. Thus, isolating the splenic vein from the pancreatic parenchyma is deemed unnecessary. Trial Registration: ClinicalTrials.gov Identifier: NCT02871804.

  595. Laparoscopic liver cyst fenestration with real-time indocyanine green fluorescence-guided surgery: a case report. International-journal

    Norikazu Une, Atsushi Fujio, Hiroaki Mitsugashira, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Wataru Nakanishi, Kazuaki Tokodai, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Journal of surgical case reports　2021　(5)　rjab196　2021/05

    DOI： 10.1093/jscr/rjab196 　

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    Laparoscopic fenestration (LF) has recently been considered a standard procedure for nonparasitic symptomatic liver cysts. Here, we report a case of LF that was safely performed using real-time indocyanine green (ICG) fluorescence-guided surgery. A 74-year-old woman presented with right upper abdominal pain and poor dietary intake. The patient was diagnosed with symptomatic liver cysts and underwent LF. One hour before surgery, ICG (2.5 mg) was intravenously administered to the patient. ICG fluorescence imaging clearly showed the biliary ducts and distinguished the cysts from the liver parenchyma. We could resect only the cyst walls as wide as possible under the guidance of both white light and fluorescence imaging. There were no signs of postoperative symptom recurrence. Detection of ICG fluorescence in the liver parenchyma is as important as ICG cholangiography for fenestration. Laparoscopic liver cyst fenestration with real-time ICG fluorescence-guided surgery is safe and can be used as a standard procedure.

  596. Development of a system combining comprehensive genotyping and organoid cultures for identifying and testing genotype-oriented personalised medicine for pancreatobiliary cancers

    Masahiro Shiihara, Tomohiko Ishikawa, Yuriko Saiki, Yuko Omori, Katsuya Hirose, Shinichi Fukushige, Naoki Ikari, Ryota Higuchi, Masakazu Yamamoto, Takanori Morikawa, Kei Nakagawa, Hiroki Hayashi, Masamichi Mizuma, Hideo Ohtsuka, Fuyuhiko Motoi, Michiaki Unno, Yasunobu Okamura, Kengo Kinoshita, Toru Furukawa

    European Journal of Cancer　148　239-250　2021/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.ejca.2021.01.047 　

    ISSN： 0959-8049

  597. Diabetic control and nutritional status up to 1 year after total pancreatectomy: a nationwide multicentre prospective study

    H Suto, K Kamei, H Kato, T Misawa, M Unno, H Nitta, S Satoi, Y Kawabata, M Ohtsuka, T Rikiyama, T Sudo, I Matsumoto, T Hirao, K Okano, Y Suzuki, N Sata, S Isaji, M Sugiyama, Y Takeyama

    British Journal of Surgery　2021/04/02

    Publisher: Oxford University Press (OUP)

    DOI： 10.1093/bjs/znab097 　

    ISSN： 0007-1323

    eISSN： 1365-2168

  598. 食道扁平上皮癌におけるTXNRD1とHO-1発現と術前化学放射線療法抵抗性についての関連

    赤石 隆二郎, 藤島 史喜, 石田 裕嵩, 福富 俊明, 岡本 宏史, 高屋 快, 佐藤 千晃, 谷山 裕亮, 海野 倫明, 亀井 尚, 笹野 公伸

    日本外科学会定期学術集会抄録集　121回　PS-2　2021/04

    Publisher: (一社)日本外科学会

  599. 胆嚢癌における癌関連線維芽細胞のTenascin-CとPodoplaninは移動浸潤能を促進する

    佃 和彦, 石田 昌玄, 國米 崇, 宮崎 健人, 三田地 克昂, 吉町 信吾, 三浦 孝之, 前田 晋平, 有明 恭平, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-6　2021/04

    Publisher: (一社)日本外科学会

  600. 肝門部領域胆管癌に対する肝移植-for vs against- 局所進行肝門部領域胆管癌に対する肝移植の意義

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 益田 邦洋, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　DB-1　2021/04

    Publisher: (一社)日本外科学会

  601. 当科での肝・膵移植における術前リツキシマブ脱感作療法の成績と課題

    柏舘 俊明, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 西村 隆一, 小笠原 弘之, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-5　2021/04

    Publisher: (一社)日本外科学会

  602. 当院における小児肝移植の現状と今後の課題

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-5　2021/04

    Publisher: (一社)日本外科学会

  603. 東北地方における臓器提供増加にむけた取り組みと課題について 移植外科医の立場から

    藤尾 淳, 宮城 重人, 小笠原 弘之, 佐々木 健吾, 柏舘 俊明, 中西 渉, 西村 隆一, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-7　2021/04

    Publisher: (一社)日本外科学会

  604. 十二指腸空腸バイパス術の非アルコール性脂肪肝炎改善効果における胆膵路の役割

    市川 英孝, 田中 直樹, 井本 博文, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 藤島 史喜, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-7　2021/04

    Publisher: (一社)日本外科学会

  605. 家族性大腸腺腫症に対する治療戦略

    大沼 忍, 神山 篤史, 初沢 遊人, 小林 実, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 市川 英孝, 小野 翼, 佐藤 圭佑, 田山 穂高, 森川 孝則, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-8　2021/04

    Publisher: (一社)日本外科学会

  606. 外科におけるAI利用の現状と展開 AIによる食道癌術前リンパ節診断

    高橋 梢, 大村 和元, 高浪 健太郎, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 八嶋 嘉之, 石田 孝宣, 海野 倫明, 高瀬 圭, 亀井 尚

    日本外科学会定期学術集会抄録集　121回　NES-6　2021/04

    Publisher: (一社)日本外科学会

  607. 食道胃接合部癌に対する至適な手術術式 食道胃接合部癌に対する至適リンパ節郭清範囲と術式選択

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 高屋 快, 福富 俊明, 小関 健, 植木 俊輔, 篠崎 康晴, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　121回　SY-5　2021/04

    Publisher: (一社)日本外科学会

  608. 高解像度内圧測定検査を用いた胸部食道癌手術後の嚥下機能評価に関する検討

    小関 健, 佐藤 千晃, 谷山 裕亮, 岡本 宏史, 福富 俊明, 氏家 直人, 植木 俊輔, 篠崎 康晴, 石田 孝宜, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　121回　SF-5　2021/04

    Publisher: (一社)日本外科学会

  609. 胸部食道癌術後の咽喉頭逆流についての検討

    安藤 涼平, 佐藤 千晃, 福富 俊明, 岡本 宏史, 高屋 快, 谷山 裕亮, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　121回　SF-1　2021/04

    Publisher: (一社)日本外科学会

  610. 食道扁平上皮癌におけるSgk1発現と術前化学療法治療効果との関連性

    植木 俊輔, 藤島 史喜, 小関 健, 福富 俊明, 岡本 宏史, 高屋 快, 佐藤 千晃, 谷山 裕亮, 亀井 尚, 海野 倫明, 笹野 公伸

    日本外科学会定期学術集会抄録集　121回　PS-2　2021/04

    Publisher: (一社)日本外科学会

  611. 食道扁平上皮癌におけるTXNRD1とHO-1発現と術前化学放射線療法抵抗性についての関連

    赤石 隆二郎, 藤島 史喜, 石田 裕嵩, 福富 俊明, 岡本 宏史, 高屋 快, 佐藤 千晃, 谷山 裕亮, 海野 倫明, 亀井 尚, 笹野 公伸

    日本外科学会定期学術集会抄録集　121回　PS-2　2021/04

    Publisher: (一社)日本外科学会

  612. 乳癌治療において遺伝子コンパニオン診断をどの時点で行いどう生かすか 乳癌治療におけるがん遺伝子パネル検査の最適な活用の考察

    多田 寛, 宮下 穣, 原田 成美, 佐藤 章子, 濱中 洋平, 江幡 明子, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　121回　SY-4　2021/04

    Publisher: (一社)日本外科学会

  613. 内分泌療法耐性乳癌における代謝の変化

    進藤 晴彦, 原田 成美, 多田 寛, 宮下 穣, 濱中 洋平, 佐藤 章子, 江幡 明子, 本成 登貴和, 金井 綾子, 柳垣 美歌, 角掛 聡子, 鈴木 貴, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　121回　PS-1　2021/04

    Publisher: (一社)日本外科学会

  614. BRACAnalysis保険適用後の現状と問題点

    江幡 明子, 多田 寛, 宮下 穣, 原田 成美, 佐藤 章子, 濱中 洋平, 深町 佳世子, 佐藤 未来, 金井 綾子, 本成 登貴和, 柳垣 美歌, 進藤 晴彦, 角掛 聡子, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　121回　PS-3　2021/04

    Publisher: (一社)日本外科学会

  615. 【肝・胆道系症候群(第3版)-その他の肝・胆道系疾患を含めて-肝外胆道編】肝外胆管(胆管、胆嚢管、総胆管) 腫瘍 肝外胆管癌(総論)

    益田 邦洋, 中川 圭, 森川 孝則, 海野 倫明

    日本臨床　別冊　(肝・胆道系症候群III)　23-27　2021/04

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  616. 【肝・胆道系症候群(第3版)-その他の肝・胆道系疾患を含めて-肝外胆道編】胆嚢 その他 内胆汁瘻

    中川 圭, 高舘 達之, 青木 修一, 益田 邦洋, 海野 倫明

    日本臨床　別冊　(肝・胆道系症候群III)　345-348　2021/04

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  617. 胆道再建術後症例における肝切除術後SSI発生要因とその対策

    森川 孝則, 石田 晶玄, 伊関 雅裕, 吉町 信吾, 青木 修一, 畠 達夫, 三浦 孝之, 前田 晋平, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-3　2021/04

    Publisher: (一社)日本外科学会

  618. 外科治療における診療ガイドライン出版後の普及、活用と評価 直腸神経内分泌腫瘍外科的切除症例の膵・消化管神経内分泌腫瘍診療ガイドライン2019による評価

    梶原 大輝, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 小林 実, 初沢 悠人, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PD-5　2021/04

    Publisher: (一社)日本外科学会

  619. metabolic syndromeに対する外科治療の現状と展開 スリーブ・バイパス術後の糖尿病非寛解症例の検討

    井本 博文, 田中 直樹, 小林 実, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PD-5　2021/04

    Publisher: (一社)日本外科学会

  620. 機能温存と長期病勢コントロールの両立を目指した炎症性腸疾患の術式選択 クローン病術後症例における外科的再発危険因子および生物学的製剤の早期投与による再発予防効果についての検討

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PD-3　2021/04

    Publisher: (一社)日本外科学会

  621. 十二指腸空腸バイパス術の非アルコール性脂肪肝炎改善効果における胆膵路の役割

    市川 英孝, 田中 直樹, 井本 博文, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 藤島 史喜, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-7　2021/04

    Publisher: (一社)日本外科学会

  622. HALSと比較した腹腔鏡補助下大腸全摘・回腸嚢肛門吻合術の治療成績

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 西條 文人, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-2　2021/04

    Publisher: (一社)日本外科学会

  623. 高齢の潰瘍性大腸炎患者に対する緊急手術と術後合併症対策

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 西條 文人, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　SF-8　2021/04

    Publisher: (一社)日本外科学会

  624. 腹腔鏡下幽門側胃切除術における左副肝動脈の肝血流支配

    青木 豪, 田中 直樹, 初沢 悠人, 小林 実, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 大沼 忍, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-7　2021/04

    Publisher: (一社)日本外科学会

  625. 家族性大腸腺腫症に対する治療戦略

    大沼 忍, 神山 篤史, 初沢 遊人, 小林 実, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 市川 英孝, 小野 翼, 佐藤 圭佑, 田山 穂高, 森川 孝則, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-8　2021/04

    Publisher: (一社)日本外科学会

  626. 線維化マーカーtissue inhibitr of metalloproteinase-1の新たな指標としての有用性

    佐藤 圭佑, 鈴木 秀幸, 唐澤 秀明, 初沢 悠人, 小林 実, 梶原 大輝, 山村 明寛, 神山 篤史, 渡辺 和宏, 森川 孝則, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-3　2021/04

    Publisher: (一社)日本外科学会

  627. 手術前後における外科医の自己学習に関するアンケート調査

    小林 実, 大沼 忍, 及川 昌也, 土屋 誉, 初沢 悠人, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-4　2021/04

    Publisher: (一社)日本外科学会

  628. 直腸癌に対する術前化学放射線療法が術後短期成績に与える影響について

    初沢 悠人, 大沼 忍, 小林 実, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 森川 孝則, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　121回　PS-6　2021/04

    Publisher: (一社)日本外科学会

  629. Clinical practice guidelines for the management of biliary tract cancers 2019: the 3rd English edition

    Masato Nagino, Satoshi Hirano, Hideyuki Yoshitomi, Taku Aoki, Katsuhiko Uesaka, Michiaki Unno, Tomoki Ebata, Masaru Konishi, Keiji Sano, Kazuaki Shimada, Hiroaki Shimizu, Ryota Higuchi, Toshifumi Wakai, Hiroyuki Isayama, Takuji Okusaka, Toshio Tsuyuguchi, Yoshiki Hirooka, Junji Furuse, Hiroyuki Maguchi, Kojiro Suzuki, Hideya Yamazaki, Hiroshi Kijima, Akio Yanagisawa, Masahiro Yoshida, Yukihiro Yokoyama, Takashi Mizuno, Itaru Endo

    Chinese Journal of Digestive Surgery　20　(4)　359-375　2021/04

    DOI： 10.3760/cma.j.cn115610-20210303-00107 　

    ISSN： 1673-9752

  630. Intracholecystic papillary neoplasm arising in the cystic duct and extending into common bile duct: a case report.

    Masahiro Iseki, Masamichi Mizuma, Yasutaka Aoki, Shuichi Aoki, Tatsuo Hata, Tatsuyuki Takadate, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Takashi Kamei, Kiyoshi Kume, Atsushi Kanno, Atsushi Masamune, Yuko Omori, Yusuke Ono, Yusuke Mizukami, Toru Furukawa, Michiaki Unno

    Clinical journal of gastroenterology　14　(2)　668-677　2021/04

    DOI： 10.1007/s12328-020-01311-4 　

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    An 83-year-old man without specific symptoms was referred to our hospital for further evaluation and treatment of apparent double primary tumors of the cystic duct and common bile duct. Computed tomography showed contrast-enhanced solid tumors in the cystic duct and common bile duct. Magnetic resonance imaging showed that the bile duct tumor was isointense on T1-weighted images and had low intensity on T2-weighted images. In addition, the bile duct tumor showed high intensity on diffusion-weighted images. Endoscopic ultrasonography revealed the tumor of the common bile duct and endoscopic retrograde cholangiopancreatography demonstrated a filling defect in the bile duct. The cystic duct was not identified on endoscopic ultrasonography or endoscopic retrograde cholangiopancreatography. Transpapillary biopsy of the bile duct tumor showed adenocarcinoma. The patient was diagnosed with double primary tumors of the cystic duct and the common bile duct and underwent subtotal stomach-preserving pancreaticoduodenectomy. Microscopic examination with molecular profiling of the tumors revealed a high-grade noninvasive intracholecystic papillary neoplasm of the cystic duct extending into the common bile duct and forming a tubulopapillary neoplasm with invasion of the common bile duct.

  631. Surgical resection for liver metastasis and local recurrence of pheochromocytoma 16 years after primary surgery: A case report. International-journal

    Mineto Ohta, Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanisihi, Michiaki Unno, Takashi Kamei

    International journal of surgery case reports　81　105712-105712　2021/04

    DOI： 10.1016/j.ijscr.2021.105712 　

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    INTRODUCTION AND IMPORTANCE: Pheochromocytomas arise from the adrenal medulla and are rare. Pheochromocytomas metastasize to bone, lung and liver, and surgery might be the curative treatment. However, few cases are detected when they are resectable lesions because of difficulty in diagnosis and rapid growth. We herein report a patient who underwent resection of liver metastasis and local recurrence of pheochromocytoma. CASE PRESENTATION: A 74-year-old woman visited our hospital for treatment for liver and retroperitoneal tumors. She had undergone left adrenal gland resection for pheochromocytoma 16 years earlier. Eleven years after primary surgery, breast cancer was diagnosed and resected. During the breast cancer follow-up, a liver tumor was identified with computed tomography. Breast cancer recurrence and metastasis were considered, so chemotherapy was administered first. However, the liver tumor gradually enlarged, and another lesion appeared in the retroperitoneum. The tumors were diagnosed as pheochromocytoma recurrence using 123I-metaiodobenzylguanidine scintigraphy, and she underwent resection of the local recurrence and liver metastasis. She was discharged on postoperative day 25 without complications, and no evidence of recurrence occurred more than 3.5 years postoperatively. CLINICAL DISCUSSION: All pheochromocytomas have metastatic potential; however, there are no reliable markers to predict malignancy. Early detection of recurrence by regular imaging and complete resection are important in the treatment. If the recurrence was oligometastasis and tumor growth is slow, surgical resection may be eligible. CONCLUSION: A favorable outcome resulted from complete resection for liver metastasis and local recurrence of pheochromocytoma.

  632. A case of esophageal achalasia presenting with empyema and septic shock differentiated from esophageal rupture.

    Ryohei Ando, Chiaki Sato, Toshiaki Fukutomi, Hiroshi Okamoto, Kai Takaya, Yusuke Taniyama, Michiaki Unno, Takashi Kamei

    Clinical journal of gastroenterology　14　(2)　422-426　2021/04

    DOI： 10.1007/s12328-021-01349-y 　

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    The patient was a 44-year-old man with a history of schizophrenia. He had a history of esophageal dysphagia and vomiting and presented with sudden strong epigastric pain. He was taken to a medical emergency center in a state of septic shock. Computed tomography revealed a left thoracic abscess, and esophageal rupture was suspected. He was referred to our department for treatment. Gastrointestinal series and gastrointestinal endoscopy revealed marked esophageal dilation and strong contraction of the lower esophageal sphincter. We, therefore, diagnosed the patient with empyema thoracis secondary to aspiration pneumonia due to esophageal achalasia. Conservative treatment with antibiotics and computed tomography-guided chest drainage was initiated, but the inflammation persisted. Thus, we successfully performed a per-oral endoscopic myotomy to manage achalasia symptoms.

  633. Improvement of hepatocyte engraftment by co‐transplantation with pancreatic islets in hepatocyte transplantation

    Yoshikatsu Saitoh, Akiko Inagaki, Ibrahim Fathi, Takehiro Imura, Hiroyasu Nishimaki, Hiroyuki Ogasawara, Muneyuki Matsumura, Shigehito Miyagi, Yohichi Yasunami, Michiaki Unno, Takashi Kamei, Masafumi Goto

    Journal of Tissue Engineering and Regenerative Medicine　15　(4)　361-374　2021/04

    Publisher: Wiley

    DOI： 10.1002/term.3170 　

    ISSN： 1932-6254

    eISSN： 1932-7005

  634. MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy. International-journal

    Tatsuo Hata, Masamichi Mizuma, Kunihiro Masuda, Kazuharu Chiba, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Annals of surgical oncology　28　(4)　2235-2245　2021/04

    DOI： 10.1245/s10434-020-09440-3 　

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    BACKGROUND: Some presumed resectable pancreatic cancer patients harbor radiographically occult metastases that are incidentally identified at the time of abdominal exploration. This study aims to identify novel diagnostic or predictive microRNA (miRNA) markers for subclinical peritoneal dissemination in patients with pancreatic cancer undergoing abdominal exploration. METHODS: Peritoneal lavage fluid samples were harvested from 74 patients with pancreatic cancer at the time of staging laparoscopy. Microarray analysis was performed using peritoneal lavage fluids with positive and negative cytology. Candidate microRNA expression was quantified and validated by droplet-digital PCR assays. RESULTS: In the miRNA array analysis, miR-593-3p showed significant upregulation in peritoneal lavage fluids with positive cytology. Of the 74 patients validated, peritoneal lavage fluids with positive cytology had significantly higher expression of miR-593-3p than those with negative cytology (P < 0.001). Even in cases with no peritoneal dissemination and negative cytology, multivariate analysis revealed that elevated miR-593-3p expression was significantly correlated with worse overall survival than those with low expression (hazard ratio: 3.474, P = 0.042). Of the 48 patients who underwent pancreatectomy, multivariate analysis also demonstrated that higher expression of miR-593-3p in peritoneal lavage was the only significant poor prognostic marker influencing both overall survival (hazard ratio: 23.38, P = 0.005) and recurrence-free survival (hazard ratio: 5.700, P = 0.002). CONCLUSIONS: Elevated miR-593-3p expression in peritoneal lavage suggests the presence of subclinical micrometastasis even in cases with localized pancreatic cancer, and miR-593-3p could be a useful prognostic predictor for pancreatic cancer patients undergoing staging laparoscopy.

  635. Pathways for the development of multiple epithelial types of intraductal papillary mucinous neoplasm of the pancreas

    Toshikazu Kobayashi, Yuko Omori, Yusuke Ono, Hidenori Karasaki, Yusuke Mizukami, Naohiko Makino, Fuyuhiko Motoi, Michiaki Unno, Yoshiyuki Ueno, Toru Furukawa

    Journal of Gastroenterology　56　(6)　581-592　2021/04/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00535-021-01783-2 　

    ISSN： 0944-1174

    eISSN： 1435-5922

  636. Increased neutrophil-lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification. International-journal

    Takayuki Miura, Hideo Ohtsuka, Takeshi Aoki, Shuichi Aoki, Tatsuo Hata, Tatsuyuki Takadate, Shimpei Maeda, Kyohei Ariake, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Fumiyoshi Fujishima, Takashi Kamei, Hironobu Sasano, Michiaki Unno

    BMC surgery　21　(1)　176-176　2021/03/31

    DOI： 10.1186/s12893-021-01178-3 　

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    BACKGROUND: The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed the ability to predict the recurrence of such markers after curative resection in patients with these neoplasms. METHODS: Circulating/systemic neutrophil-lymphocyte, monocyte-lymphocyte, platelet-lymphocyte, and platelet-white cell ratios were evaluated in 120 patients who underwent curative resection for well-differentiated pancreatic neuroendocrine neoplasms without synchronous distant metastasis between 2001 and 2018. Recurrence-free-survival and overall survival were compared using Kaplan-Meier analysis and log-rank tests. Univariate or multivariate analyses, using a Cox proportional hazards model, were used to calculate hazard ratios with 95% confidence intervals. RESULTS: Univariate analysis demonstrated that preoperative neutrophil-lymphocyte ratio, tumor size, European Neuroendocrine Tumor Society TMN classification, 2017 World Health Organization classification, and venous invasion were associated with recurrence. The optimal preoperative neutrophil-lymphocyte ratio cut-off value was 2.62, based on receiver operating characteristic curve analysis. In multivariate analysis, a higher preoperative neutrophil-lymphocyte ratio (HR = 3.49 95% CI 1.05-11.7; P = 0.042) and 2017 World Health Organization classification (HR = 8.81, 95% CI 1.46-168.2; P = 0.015) were independent recurrence predictors. CONCLUSIONS: The circulating/systemic neutrophil-lymphocyte ratio is a useful and convenient preoperative prognostic marker of recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification.

  637. Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer. International-journal

    Katsutaka Mitachi, Kyohei Ariake, Hiroki Shima, Satoko Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Hideo Ohtsuka, Takashi Kamei, Kazuhiko Igarashi, Michiaki Unno

    Scientific reports　11　(1)　6541-6541　2021/03/22

    DOI： 10.1038/s41598-021-86099-0 　

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    The collagen gel droplet-embedded drug sensitivity test (CD-DST) was revealed to be useful for predicting the effect of S-1 adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC). However, collection of an adequate number of PDAC cells is difficult due to the surrounding fibroblasts. Thus, the aim of this study was to discover novel biomarkers to predict chemosensitivity based on the CD-DST results. Proteomics analysis was performed using liquid chromatography tandem mass spectrometry (LC-MS/MS). Candidate proteins were validated in patients with 5-FU CD-DST results via immunohistochemistry (IHC). The relationships between the candidate proteins and the effect of the adjuvant S-1 were investigated via IHC. Among the 2696 proteins extracted by LC-MS/MS, C1TC and SAHH could accurately predict the CD-DST results. Recurrence-free survival (RFS) was significantly improved in the IHC-positive group compared with the IHC-negative group in both factors. The negative group did not show a significant difference from the group that did not receive S-1. The double-positive group was associated with significantly prolonged RFS compared to the no adjuvant chemotherapy group. C1TC and SAHH have been shown to be useful biomarkers for predicting 5-FU sensitivity as a substitute for the CD-DST in adjuvant chemotherapy for PDAC.

  638. Serine/Threonine Kinase 11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Yuko Omori, Yusuke Ono, Takanori Morikawa, Fuyuhiko Motoi, Ryota Higuchi, Masakazu Yamamoto, Yuko Hayakawa, Hidenori Karasaki, Yusuke Mizukami, Michiaki Unno, Toru Furukawa

    Annals of Surgery　Publish Ahead of Print　(2)　e384-e395　2021/03/03

    Publisher: Ovid Technologies (Wolters Kluwer Health)

    DOI： 10.1097/sla.0000000000004842 　

    ISSN： 0003-4932

  639. IBD関連腫瘍の診療最前線 潰瘍性大腸炎関連大腸癌の発症時年齢による違い

    神山 篤史, 大沼 忍, 海野 倫明

    日本消化器病学会雑誌　118　(臨増総会)　A170-A170　2021/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  640. 高齢者胃癌の周術期成績

    田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　93回　230-230　2021/03

    Publisher: (一社)日本胃癌学会

  641. S-1+低用量分割シスプラチンによる術前化学療法の有用性(Preoperative chemotherapy with S-1 plus weekly low-dose cisplatin for advanced gastric cancer)

    山村 明寛, 田中 直樹, 青木 豪, 井本 博文, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　93回　324-324　2021/03

    Publisher: (一社)日本胃癌学会

  642. IBD関連腫瘍の診療最前線 潰瘍性大腸炎関連大腸癌の発症時年齢による違い

    神山 篤史, 大沼 忍, 海野 倫明

    日本消化器病学会雑誌　118　(臨増総会)　A170-A170　2021/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  643. Salvage esophagectomy for local recurrent esophageal cancer after definitive chemoradiotherapy followed by photodynamic therapy: A case report. International-journal

    Wataru Hirose, Yusuke Taniyama, Fumiyoshi Fujishima, Chiaki Sato, Michiaki Unno, Takashi Kamei

    International journal of surgery case reports　80　105617-105617　2021/03

    DOI： 10.1016/j.ijscr.2021.02.003 　

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    INTRODUCTION: Photodynamic therapy (PDT) is performed as a salvage treatment for patients with residual or recurrent esophageal cancer after chemoradiotherapy (CRT). Although PDT is considered less invasive than salvage surgery, it is unclear how deep its effects are and whether it causes damage to adjacent tissues. Herein, we report a case of esophageal cancer treated with PDT followed by esophagectomy. In this case, we evaluated the effect of PDT on adjacent tissues based on surgical and pathological examination. PRESENTATION OF CASE: A 58-year-old man with dysphagia was diagnosed with esophageal squamous cell carcinoma (SqCC; T1N0M0, Stage I) in the upper thoracic esophagus. He underwent definitive CRT with two courses of 5-fluorouracil and cisplatin every 4 weeks with 60 Gy of radiation. Twelve months after CRT, endoscopic examination revealed local recurrence, and PDT using talaporfin sodium was performed. The tumor recurred again 6 months after PDT, and robot-assisted thoracoscopic esophagectomy was performed as a definitive treatment. Tissues around the left side of the esophagus and thoracic duct were tightly adherent with severe fibrosis and were successfully removed by extended resection. Histopathological examinations showed that the esophageal wall and peri-esophageal tissue were replaced by fibrous tissue and this extended even beyond the tumor. DISCUSSION: The primary tumor was limited to the submucosal layer, and the target for irradiation had some longitudinal margins. Therefore, PDT can cause intense inflammation in tissues adjacent to the tumor. CONCLUSIONS: It is necessary to consider the location when performing salvage esophagectomy after PDT.

  644. Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020: (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012).

    Takahiro Nakazawa, Terumi Kamisawa, Kazuichi Okazaki, Shigeyuki Kawa, Susumu Tazuma, Takayoshi Nishino, Dai Inoue, Itaru Naitoh, Takayuki Watanabe, Kenji Notohara, Kensuke Kubota, Hirotaka Ohara, Atsushi Tanaka, Hajime Takikawa, Atsushi Masamune, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　28　(3)　235-242　2021/03

    DOI： 10.1002/jhbp.913 　

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    Several years have passed since the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012 were published. New findings and knowledge have accumulated since then. The Research Committees for IgG4-related Diseases and for Intractable Diseases of the Liver and Biliary Tract, in association with the Ministry of Health, Labor, and Welfare of Japan and the Japan Biliary Association, have established a working group consisting of researchers specializing in IgG4-SC and have drawn up new clinical diagnostic criteria for IgG4-SC 2020. The diagnosis of IgG4-SC is based on a combination of the following six criteria: (a) narrowing of the intra- or extrahepatic bile duct; (b) thickening of the bile duct wall; (c) serological findings; (d) pathological findings; (e) other organ involvement; and (f) effectiveness of steroid therapy. These new diagnostic criteria for IgG4-SC are useful in practice for general physicians and other non-specialists.

  645. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort

    Itaru Naitoh, Terumi Kamisawa, Atsushi Tanaka, Takahiro Nakazawa, Kensuke Kubota, Hajime Takikawa, Michiaki Unno, Atsushi Masamune, Shigeyuki Kawa, Seiji Nakamura, Kazuichi Okazaki, Keisuke Furumatsu, Shigeaki Sawai, Takuma Goto, Toshikatsu Okumura, Daisuke Suzuki, Masayuki Otsuka, Ikuhiro Kobori, Masaya Tamano, Mitsuhito Koizumi, Yoichi Hiasa, Naoto Kawabe, Yoshiki Hirooka, Satoshi Yamamoto, Yukio Asano, Kazuo Inui, Akihiko Horiguchi, Hiroyuki Watanabe, Daishu Toya, Katsuko Hatayama, Toshiharu Ueki, Norikatsu Kinoshita, Mitsuru Sugimoto, Hiromasa Ohira, Tsuyoshi Mukai, Eiichi Tomita, Keisuke Iwata, Shogo Shimizu, Jun Suetsugu, Masahito Shimizu, Keiji Tsuji, Ryoko Ishida, Masanori Ito, Ryutaro Furukawa, Naoya Sakamoto, Masahiro Araki, Satoshi Tanno, Yasunari Sakamoto, Tetsuhide Ito, Satoshi Takai, Shinichi Ikeya, Takanori Yamada, Norihiko Kudara, Akinori Shimizu, Keiji Hanada, Yasunori Ichiki, Hideki Kitada, Michio Hifumi, Hiroyuki Kimura, Masayuki Kurosaki, Namiki Izumi, Hajime Sumi, Jun-ichi Haruta, Katsumi Hayashi, Ryo Harada, Masafumi Inoue, Shinichiro Nakamura, Tetsuya Ito, Ko Tomishima, Hiroyuki Isayama, Kyoko Oura, Tsutomu Masaki, Naoto Shimokawahara, Shirou Tanoue, Kousei Maemura, Akio Ido, Ichiro Mizushima, Mitsuhiro Kawano, Katsunori Yoshida, Makoto Naganuma, Miki Murata, Akiyoshi Nishio, Yuji Fujita, Takuma Teratani, Shohei Matsubara, Hironao Tamai, Yuu Yoshida, Ryousaku Azemoto, Ken Kamata, Tomohiro Watanabe, Takahiro Kurosu, Wasaburou Koizumi, Jun Fujita, Hideyuki Seki, Yasuhiro Ueda, Takumi Fukumoto, Takuhiro Kousaki, Kazushige Uchida, Toshimasa Ochiai, Takeshi Kawasaki, Motohiko Tanaka, Etsuji Ishida, Kenji Notohara, Hideaki Mori, Toshiyuki Mori, Hideaki Kawabata, Masatoshi Miyata, Junichi Sakagami, Yoshito Itoh, Masahiro Shiokawa, Hiroshi Seno, Noriko Watanabe, Itaru Naitoh, Hiromi Kataoka, Toshinori Aoki, Mitsuhiro Fujishiro, Toru Niihara, Hiroto Nishimata, Akira Mitoro, Hitoshi Yoshiji, Motoyuki Yoshida, Masafumi Ikeda, Kengo Tomita, Ryota Hokari, Kenji Hayasaka, Yuji Amano, Kazuhiko Shioji, Kazunao Hayashi, Shuji Terai, Michiko Nakajima, Junya Yamahana, Ryusuke Matsumoto, Hideaki Kikuchi, Akira Kanamori, Seiki Kiriyama, Shinichi Iwatsu, Yuji Kato, Shigeru Horiguchi, Takahito Yagi, Hiroyuki Okada, Kazuyoshi Ohkawa, Motohiro Hirao, Naoki Hiramatsu, Noriko Oza, Haruo Imamura, Takeshi Baba, Shigeru Nakano, Tetsuya Shinobi, Shomei Ryozawa, Masayo Motoya, Hiroshi Nakase, Noboru Kinoshita, Kei Ito, Tatsuya Miyake, Naruaki Kohge, Hiroshi Tobita, Satoru Joshita, Takeji Umemura, Shinya Kawaguchi, Kazuya Ohno, Koichi Sonobe, Akihiko Satoh, Tooru Shimosegawa, Fumihiko Miura, Minami Yagi, Keiji Sano, Atsushi Tanaka, Toshifumi Kin, Akio Katanuma, Kazuhiko Koike, Shin Miura, Atsushi Masamune, Youhei Kawashima, Tatehiro Kagawa, Seishin Azuma, Mamoru Watanabe, Mitsuyoshi Honjyo, Takao Itoi, Akira Honda, Katsumasa Kobayashi, Toru Asano, Terumi Kamisawa, Suguru Mizuno, Kazuhiko Koike, Takayoshi Nishino, Hideaki Taniguchi, Kazuto Tajiri, Ichiro Yasuda, Yoshiya Tanaka, Shinji Oe, Masaru Harada, Masanao Kurata, Mituharu Fukasawa, Nobuyuki Enomoto, Yuki Kawaji, Masayuki Kitano, Yuko Nishise, Hidetoshi Hirakawa, Tetsuya Ishizawa, Yoshiyuki Ueno, Miyuki Kaino, Yuko Fujimoto, Isao Sakaida, Kensuke Kubota

    Digestive and Liver Disease　2021/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.dld.2021.02.009 　

    ISSN： 1590-8658

  646. ASO Author Reflections: Preceding Systemic Chemotherapy Might Provide Better Prognosis for Pancreatic Ductal Adenocarcinoma with Positive Peritoneal Cytology. International-journal

    Kyohei Ariake, Masamichi Mizuma, Fuyuhiko Motoi, Michiaki Unno

    Annals of surgical oncology　2021/02/25

    DOI： 10.1245/s10434-021-09755-9 　

  647. Preceding Systemic Chemotherapy for Patients with Pancreatic Ductal Adenocarcinoma with Positive Peritoneal Cytology Provides Survival Benefit Compared with Up-Front Surgery. International-journal

    Kyohei Ariake, Masamichi Mizuma, Fuyuhio Motoi, Shimpei Maeda, Takanori Morikawa, Masaharu Ishida, Hideo Ohtsuka, Shuichi Aoki, Takayuki Miura, Tatsuyuki Takadate, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    Annals of surgical oncology　28　(11)　6246-6254　2021/02/20

    DOI： 10.1245/s10434-021-09718-0 　

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    BACKGROUND: The significance of surgical resection in pancreatic ductal adenocarcinoma (PDAC) with positive peritoneal cytology (PPC) is controversial. This study aimed to evaluate whether preceding chemotherapy could be beneficial for patients with PDAC with PPC. METHODS: Between 2017 and 2019, 34 consecutive PDAC patients diagnosed with PPC without distant metastasis were retrospectively reviewed. Twenty-three patients did not receive neoadjuvant treatment (NAT) and 11 received NAT. All patients received systemic chemotherapy after PPC was confirmed, and they underwent surgical resection if PPC turned negative. The treatment course, ratio of conversion surgery (CS), and prognosis were evaluated. Moreover, the prognosis of PPC patients who underwent up-front surgery without NAT between 2003 and 2016 was analyzed as a comparative cohort. RESULTS: The median survival time (MST) of the patients without NAT was 31.4 months. CS was performed in 52.2% of the patients. Patients who underwent CS had better prognoses than those who did not undergo CS (p = 0.005). The CS rate was significantly higher in resectable PDAC (78.5%) than in borderline/unresectable PDAC (11.1%) (p = 0.002). The prognosis of patients with resectable PDAC was improved with preceding chemotherapy compared with up-front surgery (MST 13.0 months; p = 0.016). After NAT, the CS rate was low (27.3%), and the MST was only 14.1 months. CONCLUSIONS: As an initial treatment for PDAC patients with PPC, chemotherapy may lead to a favorable prognosis. Especially, resectable PDAC is associated with a greater chance of improved prognosis. Future studies are required to ascertain whether up-front surgery or preceding chemotherapy should be performed for these patients.

  648. Bleeding from jejunal varices formed at the Roux-en-Y jejunum site caused by the compression of the left renal vein after living donor liver transplantation with renoportal anastomosis. International-journal

    Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Kengo Sasaki, Yoshihiro Shono, Mineto Ohta, Yoshikatsu Saitoh, Michiaki Unno, Takashi Kamei

    Surgical case reports　7　(1)　43-43　2021/02/06

    DOI： 10.1186/s40792-021-01129-3 　

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    BACKGROUND: Renoportal anastomosis is an option for the portal vein reconstruction of a liver transplantation with grade 4 portal vein thrombosis and a splenorenal shunt. Here, we report the case of gastrointestinal bleeding who underwent living donor liver transplantation (LDLT) with renoportal anastomosis. CASE PRESENTATION: Six-year-old female patient who underwent LDLT with renoportal anastomosis at 1 year of age had severe anemia with normal liver function during the follow-up period. The varices at the Roux-en-Y jejunum were considered the source of bleeding, and the compression of the left renal vein, which is known as a cause of Nutcracker syndrome, seemed to induce venous hypertension through the splenorenal shunt, which might induce the formation of the varices. She underwent percutaneous transhepatic sclerotherapy of the varices, and the anemia improved at her last follow-up, 6 months after sclerotherapy. This is the first reported case of Roux-en-Y jejunal varices bleeding related to the compression of the left renal vein after LDLT was performed with renoportal anastomosis. CONCLUSIONS: Although renoportal anastomosis should be cautiously performed when there are no options for severe portal vein thrombosis, the status of the left renal vein and new collateral formation should be observed carefully during the follow-up period in pediatric cases of renoportal anastomosis.

  649. 先天性代謝異常症の根治を目的とした羊膜由来細胞による新規細胞移植療法確立の試み

    戸子台 和哲, 沖田 ひとみ, 吉田 まなみ, 伊藤 貴子, 佐藤 将人, 田中 美也子, 齋藤 昌利, 星合 哲郎, 宮城 重人, 三木 敏生, 海野 倫明, 後藤 昌史, 亀井 尚, 東北大学病院臨床研究推進センター再生医療ユニット

    日本小児科学会雑誌　125　(2)　201-201　2021/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  650. 直腸切断術後2ヵ月で再手術を要したストーマ壊死の1例

    内藤 覚, 鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　41　(2)　248-248　2021/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  651. 消化器疾患におけるステント治療 原発性大腸癌イレウスに対する大腸ステントの有効性の検討

    神山 篤史, 大沼 忍, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　210回　49-49　2021/02

    Publisher: 日本消化器病学会-東北支部

  652. 外科的切除を行った直腸神経内分泌腫瘍症例の検討

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　74　(2)　98-98　2021/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  653. 消化器外科術後感染対策 胆道空腸吻合術既往例における肝切除術後SSI対策

    森川 孝則, 石田 晶玄, 伊関 雅裕, 青木 修一, 三浦 孝之, 前田 晋平, 高舘 達也, 有明 恭平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　41　(2)　203-203　2021/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  654. 外科的切除を行った直腸神経内分泌腫瘍症例の検討

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　74　(2)　98-98　2021/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  655. 消化器疾患におけるステント治療 原発性大腸癌イレウスに対する大腸ステントの有効性の検討

    神山 篤史, 大沼 忍, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　210回　49-49　2021/02

    Publisher: 日本消化器病学会-東北支部

  656. 献腎移植増加の為に、心停止後腎提供を増加させるための方策 酸素化灌流装置を用いた心停止腎移植の臨床研究国内一例目の報告

    西牧 宏泰, 宮城 重人, 柏舘 俊明, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 海野 倫明, 亀井 尚, 松野 直従

    日本臨床腎移植学会プログラム・抄録集　54回　65-65　2021/02

    Publisher: (一社)日本臨床腎移植学会

  657. 先天性代謝異常症の根治を目的とした羊膜由来細胞による新規細胞移植療法確立の試み

    戸子台 和哲, 沖田 ひとみ, 吉田 まなみ, 伊藤 貴子, 佐藤 将人, 田中 美也子, 齋藤 昌利, 星合 哲郎, 宮城 重人, 三木 敏生, 海野 倫明, 後藤 昌史, 亀井 尚, 東北大学病院臨床研究推進センター再生医療ユニット

    日本小児科学会雑誌　125　(2)　201-201　2021/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  658. Protection of liver sinusoids by intravenous administration of human Muse cells in a rat extra‐small partial liver transplantation model

    Yoshihiro Shono, Yoshihiro Kushida, Shohei Wakao, Yasumasa Kuroda, Michiaki Unno, Takashi Kamei, Shigehito Miyagi, Mari Dezawa

    American Journal of Transplantation　2021/01/15

    Publisher: Wiley

    DOI： 10.1111/ajt.16461 　

    ISSN： 1600-6135

    eISSN： 1600-6143

  659. Efficacy of laparoscopic sleeve gastrectomy for patient with morbid obesity and type 1 diabetes mellitus: a case report. International-journal

    Hidetaka Ichikawa, Hirofumi Imoto, Naoki Tanaka, Hiroaki Musha, Shojiro Sawada, Takeshi Naitoh, Takashi Kamei, Michiaki Unno

    Surgical case reports　7　(1)　7-7　2021/01/06

    DOI： 10.1186/s40792-020-00989-5 　

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    BACKGROUND: Bariatric surgery is effective for the treatment of patients with morbid obesity and type 2 diabetes mellitus (T2DM), for body weight loss and glycemic control. However, in Japan, there has been no previous report of the effectiveness bariatric surgery in a case of morbid obesity associated with acute onset type 1 diabetes mellitus (T1DM), in which pancreatic β-cells were destroyed and endogenous insulin was depleted. CASE PRESENTATION: A 36-year-old woman with morbid obesity and T1DM, diagnosed when she was 6 years, was admitted for bariatric surgery. At her first consultation, she had a body weight of 106.7 kg and a body mass index of 42.2 kg/m2. Her HbA1c level was 9.0%, with a required daily insulin dose of 75 units. She underwent laparoscopic sleeve gastrectomy. At 1 year after surgery, her body weight had decreased to 81.0 kg and her body mass index to 32.2 kg/m2. In addition, her daily required dose of insulin had decreased to 24 units, with an improvement in her HbA1c level to 7.7%. CONCLUSIONS: Although further evidence needs to be accumulated, including long-term outcomes, laparoscopic sleeve gastrectomy may provide an effective treatment for patients with morbid obesity and T1DM for body weight loss, improvement in HbA1c level, and insulin dose reduction.

  660. Preferable Transplant Site for Hepatocyte Transplantation in a Rat Model

    Hiroyuki Ogasawara, Akiko Inagaki, Ibrahim Fathi, Takehiro Imura, Hiroki Yamana, Yoshikatsu Saitoh, Muneyuki Matsumura, Kengo Fukuoka, Shigehito Miyagi, Yasuhiro Nakamura, Kazuo Ohashi, Michiaki Unno, Takashi Kamei, Masafumi Goto

    Cell Transplantation　30　096368972110400-096368972110400　2021/01/01

    Publisher: SAGE Publications

    DOI： 10.1177/09636897211040012 　

    ISSN： 0963-6897

    eISSN： 1555-3892

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    Intraportal injection is regarded as the current standard procedure of hepatocyte transplantation (HTx). In islet transplantation, which shares many aspects with HTx, recent studies have clarified that instant blood-mediated inflammatory reaction (IBMIR), characterized by strong innate immune responses, can cause poor engraftment, so other transplant sites to avoid such a reaction have been established. Although IBMIR was reported to occur in HTx, few reports have evaluated alternative transplant sites for HTx. In this study, we sought to determine the optimum transplant site for HTx. Rat hepatocytes (1.0 × 107) were transplanted at the 9 transplant sites (intraportal (IPO), intrasplenic (IS), liver parenchyma, subcutaneous, intraperitoneal, renal subcapsular, muscle, inguinal subcutaneous white adipose tissue, and omentum) of analbuminemic rats. The serum albumin levels, immunohistochemical staining (albumin, TUNEL, and BrdU), and in vivo imaging of the grafts were evaluated. The serum albumin levels of the IPO group were significantly higher than those of the other groups ( p &lt; .0001). The BrdU-positive hepatocyte ratio of liver in the IS group (0.9% ± 0.2%) was comparable to that of the IPO group (0.9% ± 0.3%) and tended to be higher than that of the spleen in the IS group (0.5% ± 0.1%, p = .16). Considering the in vivo imaging evaluation and the influence of splenectomy, the graft function in the IS group may be almost entirely achieved by hepatocytes that have migrated to the liver. The present study clearly showed that the intraportal injection procedure is more efficient than other procedures for performing HTx

  661. 大腸全摘術後のstoma outlet obstructionの危険因子の抽出

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 高橋 真紀, 大沼 忍, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　37　(1)　142-142　2021/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  662. 医原性膵管損傷による膵炎併発膵頭部癌に対して術前補助療法後に切除した1例

    千葉 和治, 水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 高舘 達之, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    癌と化学療法　48　(1)　118-120　2021/01

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  663. Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Pancreatic Ductal Adenocarcinoma. International-journal

    Yasuko Tatewaki, Chiaki Maeda Terao, Kyohei Ariake, Ryoko Saito, Tatsushi Mutoh, Hideo Shimomura, Fuyuhiko Motoi, Masamichi Mizuma, Hayato Odagiri, Michiaki Unno, Yasuyuki Taki

    Frontiers in oncology　11　646141-646141　2021

    DOI： 10.3389/fonc.2021.646141 　

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    Objectives: Metabolic tumor volume (MTV) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is a promising prognostic predictor in pancreatic ductal adenocarcinoma (PDAC). However, the optimal segmentation method and threshold value to determine MTV for PDAC are still unclear. We explored the optimal method and threshold value for the prognostic value of MTV measured on pre-treatment 18F-FDG-PET/CT. Methods: Seventy-three patients with resected PDAC who underwent 18F FDG-PET/CT before surgical resection were enrolled. MTV values of the tumor were measured on FDG-PET/CT by the two fixed-threshold methods using threshold values as 2.0, 2.5, 3.0, and 3.5 for the absolute method and 35%, 40%, 42%, 45%, and 50% for the relative method. Receiver operating characteristic curve analysis for prediction of 1-year survival rates was conducted for determining the optimal threshold values, and we selected the optimal method and threshold value considering area under the curve. The prognostic values of each FDG-PET/CT parameter for disease-specific survival and recurrence-free survival were assessed with Kaplan-Meier method and Cox proportional hazard models. Results: In receiver operating characteristic curve analysis, MTV by the fixed-absolute threshold method based on a threshold value of 3.5 (MTV3.5) performed best in our study with area under the curve 0.724, sensitivity of 65%, and specificity of 75%. In univariate and multivariate analyses, MTV3.5 was significantly associated with disease-specific and recurrence-free survival. Conclusions: MTV3.5 by absolute threshold on pre-treatment FDG-PET/CT was the best independent prognostic predictor in resectable PDAC compared with other absolute threshold values and relative threshold values.

  664. Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition.

    Masato Nagino, Satoshi Hirano, Hideyuki Yoshitomi, Taku Aoki, Katsuhiko Uesaka, Michiaki Unno, Tomoki Ebata, Masaru Konishi, Keiji Sano, Kazuaki Shimada, Hiroaki Shimizu, Ryota Higuchi, Toshifumi Wakai, Hiroyuki Isayama, Takuji Okusaka, Toshio Tsuyuguchi, Yoshiki Hirooka, Junji Furuse, Hiroyuki Maguchi, Kojiro Suzuki, Hideya Yamazaki, Hiroshi Kijima, Akio Yanagisawa, Masahiro Yoshida, Yukihiro Yokoyama, Takashi Mizuno, Itaru Endo

    Journal of hepato-biliary-pancreatic sciences　28　(1)　26-54　2021/01

    DOI： 10.1002/jhbp.870 　

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    BACKGROUND: The Japanese Society of Hepato-Biliary-Pancreatic Surgery launched the clinical practice guidelines for the management of biliary tract cancers (cholangiocarcinoma, gallbladder cancer, and ampullary cancer) in 2007, then published the 2nd version in 2014. METHODS: In this 3rd version, clinical questions (CQs) were proposed on six topics. The recommendation, grade for recommendation, and statement for each CQ were discussed and finalized by an evidence-based approach. Recommendations were graded as Grade 1 (strong) or Grade 2 (weak) according to the concepts of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. RESULTS: The 31 CQs covered the six topics: (a) prophylactic treatment, (b) diagnosis, (c) biliary drainage, (d) surgical treatment, (e) chemotherapy, and (f) radiation therapy. In the 31 CQs, 14 recommendations were rated strong and 14 recommendations weak. The remaining three CQs had no recommendation. Each CQ includes a statement of how the recommendations were graded. CONCLUSIONS: This latest guideline provides recommendations for important clinical aspects based on evidence. Future collaboration with the cancer registry will be key for assessing the guidelines and establishing new evidence.

  665. 【胆膵領域の臨床試験Up to date〜これを読めば世界が見える〜】膵癌術前治療のエビデンス

    中川 圭, 元井 冬彦, 水間 正道, 海野 倫明

    胆と膵　42　(1)　15-21　2021/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  666. 医原性膵管損傷による膵炎併発膵頭部癌に対して術前補助療法後に切除した1例

    千葉 和治, 水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 高舘 達之, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    癌と化学療法　48　(1)　118-120　2021/01

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  667. Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model. International-journal

    Norihiko Sugisawa, Jun Yamamoto, Qinghong Han, Yuying Tan, Yoshihiko Tashiro, Hiroto Nishino, Sachiko Inubushi, Kazuyuki Hamada, Kei Kawaguchi, Michiaki Unno, Michael Bouvet, Robert M Hoffman

    Pancreas　50　(1)　93-98　2021/01/01

    DOI： 10.1097/MPA.0000000000001709 　

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    OBJECTIVES: Methionine addiction is a fundamental and general hallmark of cancer caused by enhanced methyl flux. In the present study, we effected a novel methionine-methylation blockade to target a patient-derived orthotopic xenograft model of pancreatic cancer. METHODS: The pancreatic cancer patient-derived orthotopic xenograft mouse models were randomized into 6 groups of 8 mice each and treated for 2 weeks: untreated control; azacitidine; oral recombinant methioninase (o-rMETase); o-rMETase plus cycloleucine; o-rMETase plus cycloleucine plus azacitidine (triple-methyl blockade therapy); and gemcitabine (positive control). RESULTS: Triple-methyl blockade therapy arrested tumor growth (mean relative tumor volume, 1.03 [standard deviation, 0.36]) and was significantly more effective compared with azacitidine (P = 0.0001); o-rMETase (P = 0.007); or o-rMETase plus cycloleucine (P = 0.04). Gemcitabine alone also inhibited but did not arrest tumor growth (mean relative tumor volume, 1.50 [standard deviation, 0.30]). The percentage of cancer cells that were negative for 5-methylcytosine staining in immunohistochemistry, indicating reduction of DNA methylation, increased with triple-methyl blockade therapy (37.5%), compared with gemcitabine (1.8%); o-rMETase (2.8%); azacitidine (9.0%); or o-rMETase plus cycloleucine (10.6%). CONCLUSIONS: This new concept of triple-methyl blockade therapy has clinical potential for pancreatic cancer, which is currently a recalcitrant disease.

  668. Resection rate curves by location along the small intestine provide perspectives on characteristics of Crohn’s disease

    H. Suzuki, K. Watanabe, A. Kohyama, S. Ohnuma, H. Karasawa, T. Kajiwara, M. Kobayashi, Y. Hatsuzawa, T. Kamei, M. Unno

    Colorectal Disease　2020/12/16

    Publisher: Wiley

    DOI： 10.1111/codi.15487 　

    ISSN： 1462-8910

    eISSN： 1463-1318

  669. BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma. International-journal

    Keiichi Tamai, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Akira Yasui, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Masamichi Mizuma, Michiaki Unno, Sadafumi Kawamura, Ikuro Sato, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh

    Scientific reports　10　(1)　21592-21592　2020/12/09

    DOI： 10.1038/s41598-020-78539-0 　

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    Cancer stem cells (CSCs) define a subpopulation of cancer cells that are resistant to therapy. However, little is known of how CSC characteristics are regulated. We previously showed that dormant cancer stem cells are enriched with a CD274low fraction of cholangiocarcinoma cells. Here we found that BEX2 was highly expressed in CD274low cells, and that BEX2 knockdown decreased the tumorigenicity and G0 phase of cholangiocarcinoma cells. BEX2 was found to be expressed predominantly in G0 phase and starvation induced the USF2 transcriptional factor, which induced BEX2 transcription. Comprehensive screening of BEX2 binding proteins identified E3 ubiquitin ligase complex proteins, FEM1B and CUL2, and a mitochondrial protein TUFM, and further demonstrated that knockdown of BEX2 or TUFM increased mitochondria-related oxygen consumption and decreased tumorigenicity in cholangiocarcinoma cells. These results suggest that BEX2 is essential for maintaining dormant cancer stem cells through the suppression of mitochondrial activity in cholangiocarcinoma.

  670. O6-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms. International-journal

    Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    BMC cancer　20　(1)　1195-1195　2020/12/07

    DOI： 10.1186/s12885-020-07579-6 　

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    BACKGROUND: Streptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic efficacy is relatively low in GI-NETs. Therefore, it has become pivotal to select GI-NET patients who could benefit from STZ treatment. STZ is transported via the glucose transporter 2 (GLUT2) into the cells and the loss of O6-methylguanine DNA methyltransferase (MGMT) also increases its therapeutic efficacy. Therefore, GLUT2 high and MGMT low status could be the surrogate markers of STZ. METHODS: In this study, we examined the MGMT and GLUT2 status in gastrointestinal neuroendocrine neoplasm (NEN). We studied 84 NEN cases: 33 foregut and 37 hindgut GI-NETs and 14 gastrointestinal neuroendocrine carcinomas (GI-NECs). RESULTS: In GI-NETs, MGMT scores of ≥2 and ≥ 3 were 77% (54/70) and 56% (39/70), respectively, and GLUT2 scores of ≥4 and ≥ 6 were 30% (21/70) and 4.3% (3/70), respectively. Methylation-specific polymerase chain reaction revealed that MGMT promoter methylation was detected only in 2/14 GI-NECs but none of the included GI-NETs. GLUT2 (GLUT2 score) and MGMT immunoreactivity (MGMT and H-scores) were both significantly correlated with Ki-67 labeling index (GLUT2 score: P = 0.0045, ρ = - 0.4570; MGMT score: P = 0.0064, ρ = - 0.4399; H-score: P = 0.0110, ρ = - 0.4135) and MGMT immunoreactivity were significantly correlated with GLUT2 immunoreactivity (MGMT score: P = 0.0198; H-score, P = 0.0004, ρ = 0.5483) in hindgut NETs, but not in foregut NETs. However, discrepancies from the above correlation between GLUT2 and MGMT immunoreactivity were detected in several GI-NET cases which could be potential candidates for STZ therapy. CONCLUSION: The evaluation of MGMT and GLUT2 status could provide an important information in planning STZ therapy in GI-NET patients.

  671. [食道]食道裂孔ヘルニアの手術を再考する 腹腔鏡下食道裂孔ヘルニア修復術の手技の工夫

    佐藤 千晃, 谷山 裕亮, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　WS2-2　2020/12

    Publisher: (一社)日本消化器外科学会

  672. 当院の食道癌周術期チーム医療の取り組み

    鳩山 恵一朗, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS5-5　2020/12

    Publisher: (一社)日本消化器外科学会

  673. 食道切除胃管再建頸部吻合における吻合法の検討 Collard法vs手縫い

    福富 俊明, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 熊谷 卓朗, 及川 隆洋, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS7-3　2020/12

    Publisher: (一社)日本消化器外科学会

  674. 食道胃接合部癌に対するリンパ節郭清範囲と再建術式の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 高屋 快, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 氏家 直人, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P003-2　2020/12

    Publisher: (一社)日本消化器外科学会

  675. 喉頭温存を目指した頸部食道癌に対する集学的外科治療の現状

    高屋 快, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 熊谷 卓朗, 及川 隆洋, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P010-5　2020/12

    Publisher: (一社)日本消化器外科学会

  676. Siewert type1/2食道胃接合部腺癌におけるHER2発現に関する検討

    郷右近 祐介, 藤島 史喜, 谷山 裕亮, 亀井 尚, 海野 倫明, 笹野 公伸

    日本消化器外科学会総会　75回　P015-6　2020/12

    Publisher: (一社)日本消化器外科学会

  677. 血栓性微小血管障害症を合併したS状結腸癌の1例

    佐藤 圭佑, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 海野 倫明

    癌と化学療法　47　(13)　2358-2360　2020/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  678. 3DCGソフトBlenderを用いた東北大式吻合の改良シミュレーション

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 梶原 大輝, 唐澤 秀明, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P102-2　2020/12

    Publisher: (一社)日本消化器外科学会

  679. クローン病術後の腸管不全例における微量元素を中心とした栄養状態の検討

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 梶原 大輝, 唐澤 秀明, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P102-5　2020/12

    Publisher: (一社)日本消化器外科学会

  680. 直腸癌に対するロボット支援手術 Watch and Wait後の局所再発に対するサルベージ手術

    大沼 忍, 神山 篤史, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P193-5　2020/12

    Publisher: (一社)日本消化器外科学会

  681. 80歳以上の高齢者大腸癌に対する根治切除の妥当性についての検討

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P210-5　2020/12

    Publisher: (一社)日本消化器外科学会

  682. 高度肥満を合併したS状結腸癌膀胱浸潤症例に対し化学療法・減量後根治切除し得た1例

    田山 穂高, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　47　(13)　2320-2322　2020/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  683. [総論]肥満外科の妥当性の検証と展望 BMI50以上の超重症肥満がスリーブ状胃切除術の手術成績に与える影響

    田中 直樹, 井本 博文, 上野 知孝, 青木 豪, 山村 明寛, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　75回　WS17-2　2020/12

    Publisher: (一社)日本消化器外科学会

  684. 重症糖尿病患者に対するスリーブ状胃切除術の治療成績と適応限界

    井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　75回　O23-3　2020/12

    Publisher: (一社)日本消化器外科学会

  685. Stage IV胃癌コンバージョン手術においてR0切除は長期化学療法例で期待される

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 石岡 千加史, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P075-5　2020/12

    Publisher: (一社)日本消化器外科学会

  686. cT4b左側大腸癌に対する術前治療戦略

    唐澤 秀明, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　RS11-5　2020/12

    Publisher: (一社)日本消化器外科学会

  687. 慢性膵炎に対する膵管ドレナージ術における有病期間と手術成績の検討

    佐藤 英昭, 石田 晶玄, 元井 冬彦, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 正宗 淳, 内藤 剛, 亀井 尚, 江川 新一, 海野 倫明

    膵臓　35　(6)　551-558　2020/12

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  688. [A Case of Radically Resected Sigmoid Colon Cancer with Bladder Invasion after Chemotherapy and Weight Loss in an Extremely Obese Patient].

    Hodaka Tayama, Hideaki Karasawa, Taiki Kajiwara, Hideyuki Suzuki, Akihiro Yamamura, Atsushi Kohyama, Kazuhiro Watanabe, Shinobu Ohnuma, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　47　(13)　2320-2322　2020/12

    ISSN： 0385-0684

    More details Close

    A 30's extremely obese patient(body mass index: BMI 45 kg/m2)was referred to our hospital with a chief complaint of bloody urine and stool. Colonoscopy revealed a sigmoid colon tumor. Barium enema examination revealed stenosis of the sigmoid colon. CT scan showed a tumor in the sigmoid colon, with bladder invasion. The para-aortic lymph node was partially swollen. We considered surgery to be high risk because of the patient's severe obesity. Therefore, we decided to examine the possibility of radical surgery followed by chemotherapy(mFOLFOX6/cetuximab)with weight reduction. Following this, the tumor had shrunk remarkably, and the patient's BMI decreased from 45 kg/m2 to 39 kg/m2. The visceral fat area was reduced from 298 cm2 to 199 cm2 at the umbilical level. We then performed a sigmoid colectomy with partial resection of the bladder. Thus, chemotherapy combined with weight loss enabled us to perform radical surgery safely for a locally advanced sigmoid colon cancer in a patient with severe obesity.

  689. [A Case of Sigmoid Colon Cancer with Thrombotic Microangiopathy].

    Keisuke Sato, Hideaki Karasawa, Taiki Kajiwara, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　47　(13)　2358-2360　2020/12

    ISSN： 0385-0684

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    A 50's man was referred to our hospital because of sigmoid colon cancer with multiple liver metastases and para-aortic lymph node metastases. Although blood test showed elevated D-dimer(50 μg/mL), there was no significant thrombus in contrast-enhanced CT scan. Since cancer pain and symptoms of bowel obstruction had continued after endoscopic stent placement, we resected primary lesion. Despite anemia and elevated D-dimer level had persisted after the operation, there were no obvious bleeding source nor thrombus. Continuous intravenous heparin infusion was started for hypercoagulability. Then, D-dimer and CRP levels were promptly decreased. Since schizocyte and giant platelets were observed in peripheral blood smear, he was eventually diagnosed with thrombotic microangiopathy as a paraneoplastic syndrome. However D- dimer and CRP levels were re-elevated, and it seemed to be necessary to control cancer progression. Thus, cetuximab monotherapy was started considering his performance status. After starting cetuximab, fever and CRP level were immediately improved. Cetuximab appeared to be very effective, but he died of acute subdural hematoma. Continuous intravenous heparin infusion was supposed to be effective in the treatment of thrombotic microangiopathy along with the management of cancer.

  690. 慢性膵炎に対する膵管ドレナージ術における有病期間と手術成績の検討

    佐藤 英昭, 石田 晶玄, 元井 冬彦, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 正宗 淳, 内藤 剛, 亀井 尚, 江川 新一, 海野 倫明

    膵臓　35　(6)　551-558　2020/12

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  691. 単包性エキノコックス症による多発腹腔内包虫嚢胞の1例

    西牧 宏泰, 中西 渉, 藤尾 淳, 宮城 重人, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　81　(12)　2525-2530　2020/12

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  692. 生体肝移植における動脈門脈再建困難症例に対する戦略とpitfall

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 柿崎 裕太, 小笠原 弘之, 太田 嶺人, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　75回　RS14-2　2020/12

    Publisher: (一社)日本消化器外科学会

  693. 肝細胞癌に対する腹腔鏡下肝切除術における術後疼痛コントロールの検討

    西牧 宏泰, 藤尾 敦, 宮城 重人, 戸子台 和哲, 西村 隆一, 柿崎 裕太, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS21-2　2020/12

    Publisher: (一社)日本消化器外科学会

  694. Thiel法固定したご遺体を用いた脳死ドナー臓器摘出トレーニングの有用性

    戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 大和田 祐二, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS22-1　2020/12

    Publisher: (一社)日本消化器外科学会

  695. 再肝切除症例に対する確実なPringle法の施行と癒着防止に関する工夫

    小笠原 弘之, 藤尾 淳, 西村 隆一, 中西 渉, 原 康之, 戸子台 和哲, 宮城 重人, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RSV12-4　2020/12

    Publisher: (一社)日本消化器外科学会

  696. C型肝炎SVR症例における肝切除の検討

    藤尾 淳, 宮城 重人, 太田 嶺人, 小笠原 弘之, 柿崎 裕太, 西村 隆一, 戸子台 和哲, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P241-4　2020/12

    Publisher: (一社)日本消化器外科学会

  697. 肝細胞癌症例に対する術前治療が肝切除に及ぼす影響についての検討

    西村 隆一, 宮城 重人, 戸子台 和哲, 藤尾 淳, 柿崎 裕太, 太田 嶺人, 小笠原 弘之, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P241-6　2020/12

    Publisher: (一社)日本消化器外科学会

  698. Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: a randomized clinical trial. International-journal

    Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Kengo Sasaki, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

    Annals of surgical treatment and research　99　(6)　320-328　2020/12

    DOI： 10.4174/astr.2020.99.6.320 　

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    Purpose: Enhanced recovery after surgery (ERAS) is beneficial to patients undergoing digestive surgery. However, its efficacy in patients undergoing open hepatectomy remains unclear. Methods: Consecutive patients scheduled for open hepatectomy were randomly assigned to undergo either ERAS or conventional postoperative management. The primary endpoint was the amount of time that elapsed before patients were considered medically fit for discharge (MFD) and length of hospital stay (LOHS). Secondary endpoints included morbidity, mortality, the time to first flatus, defecation, first walk, and freedom from infusion. Perioperative serum nutritional markers, insulin resistance, respiratory quotient (RQ), and resting energy expenditure (REE) were also assessed. Results: Between August 2014 and March 2017, 57 patients were randomized into 2 groups; ERAS group (n = 29) and conventional management (n = 28). The median MFD was not significantly different between the ERAS and conventional management groups (6.5 vs. 7 days; P = 0.381). Recovery from gastrointestinal paresis was significantly quicker in the ERAS group (1.8 vs. 2.4 days; P = 0.004). There were no significant differences in serum markers, insulin resistance, RQ, and REE. Conclusion: This trial did not demonstrate greater efficacy of the ERAS protocol following open hepatectomy in terms of the MFD and LOHS. However, the ERAS protocol was associated with better recovery from postoperative gastrointestinal paresis, suggesting that it is useful for patients undergoing open hepatectomy.

  699. [食道]食道裂孔ヘルニアの手術を再考する 腹腔鏡下食道裂孔ヘルニア修復術の手技の工夫

    佐藤 千晃, 谷山 裕亮, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　WS2-2　2020/12

    Publisher: (一社)日本消化器外科学会

  700. 当院の食道癌周術期チーム医療の取り組み

    鳩山 恵一朗, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS5-5　2020/12

    Publisher: (一社)日本消化器外科学会

  701. 食道切除胃管再建頸部吻合における吻合法の検討 Collard法vs手縫い

    福富 俊明, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 熊谷 卓朗, 及川 隆洋, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　RS7-3　2020/12

    Publisher: (一社)日本消化器外科学会

  702. 食道胃接合部癌に対するリンパ節郭清範囲と再建術式の検討

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 高屋 快, 福富 俊明, 及川 隆洋, 熊谷 卓朗, 氏家 直人, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P003-2　2020/12

    Publisher: (一社)日本消化器外科学会

  703. 喉頭温存を目指した頸部食道癌に対する集学的外科治療の現状

    高屋 快, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 熊谷 卓朗, 及川 隆洋, 鳩山 恵一朗, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　75回　P010-5　2020/12

    Publisher: (一社)日本消化器外科学会

  704. Siewert type1/2食道胃接合部腺癌におけるHER2発現に関する検討

    郷右近 祐介, 藤島 史喜, 谷山 裕亮, 亀井 尚, 海野 倫明, 笹野 公伸

    日本消化器外科学会総会　75回　P015-6　2020/12

    Publisher: (一社)日本消化器外科学会

  705. Stage IV胃癌コンバージョン手術においてR0切除は長期化学療法例で期待される

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 石岡 千加史, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　75回　P075-5　2020/12

    Publisher: (一社)日本消化器外科学会

  706. 【膵頭十二指腸切除の完全ガイド-定型術式から困難症例への対処法まで】手術に必要な局所解剖と術前評価 PDの術前評価 安全に手術が可能か,患者因子をどのように評価するか

    前田 晋平, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 海野 倫明

    臨床外科　75　(13)　1404-1408　2020/12

    Publisher: (株)医学書院

    ISSN： 0386-9857

    eISSN： 1882-1278

  707. 局所進行膵体部癌に対してGemcitabine併用重粒子線治療を施行後に根治切除を施行し得た1例

    宮崎 健人, 林 洋毅, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 篠藤 誠, 山田 滋, 瀧山 博年, 海野 倫明

    癌と化学療法　47　(13)　2266-2268　2020/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  708. Slug Method: A Technique for Stoma Prolapse Reduction Using High Osmolality of the 50% Glucose Solution. International-journal

    Kazuhiro Watanabe, Atsushi Kohyama, Hideyuki Suzuki, Taiki Kajiwara, Hideaki Karasawa, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Diseases of the colon and rectum　63　(12)　e565　2020/12

    DOI： 10.1097/DCR.0000000000001798 　

  709. 膵神経内分泌腫瘍術後再発例に対する集学的治療

    三浦 孝之, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　75回　RS17-2　2020/12

    Publisher: (一社)日本消化器外科学会

  710. 【最新版「胆石症マネージメント」】原発性・続発性肝内結石に対する外科的マネージメント

    大塚 英郎, 石田 晶玄, 益田 邦洋, 水間 正道, 中川 圭, 森川 孝則, 海野 倫明

    胆と膵　41　(12)　1463-1469　2020/12

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  711. New-Onset or Exacerbation of Diabetes Mellitus Is a Clue to the Early Diagnosis of Pancreatic Cancer.

    Tetsuya Takikawa, Kazuhiro Kikuta, Kiyoshi Kume, Shin Hamada, Shin Miura, Naoki Yoshida, Seiji Hongo, Yu Tanaka, Ryotaro Matsumoto, Takanori Sano, Mio Ikeda, Masahiro Iseki, Michiaki Unno, Atsushi Masamune

    The Tohoku journal of experimental medicine　252　(4)　353-364　2020/12

    DOI： 10.1620/tjem.252.353 　

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    Pancreatic ductal adenocarcinoma (PDAC), which accounts for majority of pancreatic cancers, is one of the most lethal human malignancies. Most patients are diagnosed at an advanced stage after symptom development. Early diagnosis of PDAC in asymptomatic subjects is important to improve prognosis. Diabetes mellitus (DM) is a risk factor for PDAC, and DM, especially new-onset DM, has attracted attentions as a diagnostic clue to PDAC. However, the impact of DM as a diagnostic opportunity on the prognosis of PDAC is unclear. We here retrospectively reviewed 489 PDAC patients and compared the clinical characteristics and prognosis according to the opportunities for PDAC diagnosis. PDAC was diagnosed upon presentation of symptoms, such as pain and jaundice, in 318 cases including 151 DM patients, upon new-onset or exacerbation of long-standing DM in 53 asymptomatic patients, and upon incidental detection by medical check-up or follow-up/work-up of other diseases in 118 asymptomatic patients. Asymptomatic patients including those with DM had smaller tumors, earlier disease stage, and higher resectability rates than symptomatic patients. Asymptomatic patients diagnosed in association with DM had better prognosis (median survival time, 771 days) than those diagnosed due to symptoms (343 days, P < 0.001), and similar to those diagnosed by incidental detection (869 days). The survival advantage was not evident in symptomatic patients with DM-associated signs. In conclusion, patients diagnosed in association with DM at asymptomatic stages had better prognosis than those diagnosed with symptoms. DM-associated signs might provide a clue to the early diagnosis of PDAC among asymptomatic subjects.

  712. Laparoscopic right hemicolectomy for an ascending colon cancer patient with an implantable left ventricular assist device: a case report. International-journal

    Taiki Kajiwara, Takeshi Naitoh, Yusuke Suzuki, Atsushi Kohyama, Hideaki Karasawa, Hideyuki Suzuki, Masatoshi Akiyama, Yoshikatsu Saiki, Kazuhiro Watanabe, Shinobu Ohnuma, Takashi Kamei, Michiaki Unno

    Surgical case reports　6　(1)　282-282　2020/11/09

    DOI： 10.1186/s40792-020-01064-9 　

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    BACKGROUND: Left ventricular assist devices (LVADs) currently play an important role in the treatment of patients with end-stage heart failure who require a bridge to heart transplantation or destination therapy. With the development and improvement of the LVADs, the morbidity and mortality rates are declining and life expectancies increasing, and the number of patients with LVADs requiring non-cardiac surgery is likely to increase. We present the case of a patient with implantable LVAD who underwent laparoscopic right hemicolectomy for ascending colon cancer. CASE DESCRIPTION: The patient was a 66-year-old man who underwent LVAD implantation as a BTT 3 years prior. He suffered from severe anemia at follow-up, and a colonoscopy revealed ascending colon cancer. The LVAD pump was implanted in the epigastrium. The long C-shaped subfascial driveline tunnel was made, and driveline exit site was located on the left lateral abdominal wall. We assessed the positional relationship between the tumor and the driveline using X-ray and three-dimensional computed tomography (3D CT) images. 3D CT image allowed us to easily identify the location of the driveline, and we determined to perform laparoscopic right hemicolectomy. The port sites were decided upon carefully to avoid the driveline injury, and the driveline was marked on the skin before surgery. There were no adhesions in the abdominal cavity, and both the LVAD and the driveline were observable. The trocars were in nearly the same positions as in a standard laparoscopic right hemicolectomy. During the operation, the LVAD and the driveline did not interfere with the trocars. We successfully completed a standard laparoscopic right hemicolectomy despite hemorrhagic tendency. The patient was discharged without any bleeding complications during the postoperative course. CONCLUSION: Laparoscopic surgery is feasible and safe for patients with LVADs with intensive preoperative simulation and perioperative prevention of infection.

  713. 膵臓 悪性

    畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 菅野 敦, 森川 孝則, 亀井 尚, 正宗 淳, 古川 徹, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　317-317　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  714. 大腸・小腸 良性

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 梶原 大輝, 武者 宏昭, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　170-170　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  715. 大腸 診断

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 小林 実, 初沢 悠人, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　225-225　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  716. 大腸 集学的治療

    初沢 悠人, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　229-229　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  717. メチオニンを標的とした膵癌化学療法における新規栄養療法戦略の可能性

    川口 桂, 青木 修一, 畠 達夫, 伊関 雅裕, 高館 達之, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 元井 冬彦, 亀井 尚, Hoffman Robert, 海野 倫明

    学会誌JSPEN　2　(Suppl.1)　247-247　2020/11

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  718. 膵癌切除術後合併症の重症度と周術期栄養状態の関連

    元井 冬彦, 青木 修一, 畠 達夫, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    学会誌JSPEN　2　(Suppl.1)　326-326　2020/11

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  719. 膵臓手術後の膵外分泌機能検査(PFD試験)は、術後の長期栄養状態の指標となるか

    石田 晶玄, 元井 冬彦, 青木 修一, 畠 達夫, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 水間 正道, 中川 圭, 海野 倫明

    学会誌JSPEN　2　(Suppl.1)　1025-1025　2020/11

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  720. 胆道 悪性

    中川 圭, 益田 邦洋, 青木 修一, 高舘 達之, 大塚 英郎, 伊関 雅裕, 畠 達夫, 三浦 孝之, 有明 恭平, 前田 晋平, 川口 桂, 石田 晶玄, 水間 正道, 森川 孝典, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　299-299　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  721. 膵臓 悪性

    森川 孝則, 林 洋毅, 水間 正道, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　316-316　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  722. 大腸・小腸 良性

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 梶原 大輝, 武者 宏昭, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　170-170　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  723. 大腸 診断

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 小林 実, 初沢 悠人, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　225-225　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  724. 大腸 集学的治療

    初沢 悠人, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　53　(Suppl.2)　229-229　2020/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  725. 自己免疫性肝疾患の難治例に挑む 原発性胆汁性胆管炎(PBC)、原発性硬化性胆管炎(PSC)に対する肝移植の長期成績に関する検討

    藤尾 淳, 宮城 重人, 海野 倫明

    肝臓　61　(Suppl.3)　A818-A818　2020/11

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  726. 脂肪肝合併肝移植ドナー候補に対する栄養療法

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 海野 倫明, 亀井 尚

    学会誌JSPEN　2　(Suppl.1)　1344-1344　2020/11

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  727. GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype. International-journal Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Yuko Omori, Masaharu Ishida, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Takashi Kamei, Toru Furukawa, Michiaki Unno

    Scientific reports　10　(1)　17761-17761　2020/10/20

    DOI： 10.1038/s41598-020-74868-2 　

    More details Close

    Pancreatic cystic neoplasms (PCNs) are a heterogeneous group with varying risks of malignancy. To explore the clinical utility of liquid biopsy in cyst type classification, we analyzed the GNAS/KRAS mutations in circulating cell-free DNA (cfDNA) obtained from 57 patients with histologically diagnosed PCNs, including 34 with intraductal papillary mucinous neoplasms (IPMNs) and compared the mutant allele prevalence and variant patterns with the paired resected specimens using next-generation sequencing. The positive prevalence of GNAS mutations in cfDNA of patients with IPMN (n = 11, 32%) was significantly higher than that in those with other PCNs (0%, P = 0.002). Conversely, KRAS mutations were detected in cfDNA of only 2 (6%) IPMN patients. The paired-sample comparison revealed highly concordance between the GNAS mutation status of cfDNA and resected IPMN specimens. Similar distributions of GNAS mutation positivity in cfDNA were observed across the different histological grades, whereas IPMNs with intestinal subtype showed a significantly higher prevalence of GNAS mutations than other subtypes (P = 0.030). GNAS mutation positivity in cfDNA was significantly associated with the acellular mucin pool of histological findings in primary IPMN lesions (P = 0.017). Detection of GNAS mutation in cfDNA can serve as a novel biomarker for cyst type classification and differentiation of intestinal subtype IPMN from the other PCNs.

  728. Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma. International-journal Peer-reviewed

    Thanpisit Lomphithak, Swati Choksi, Apiwat Mutirangura, Rutaiwan Tohtong, Tewin Tencomnao, Hajime Usubuchi, Michiaki Unno, Hironobu Sasano, Siriporn Jitkaew

    Cell communication and signaling : CCS　18　(1)　161-161　2020/10/09

    DOI： 10.1186/s12964-020-00661-3 　

    More details Close

    BACKGROUND: Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. However, TLR3 signaling can also harbor pro-tumorigenic consequences. Therefore, we examined the status of TLR3 in cholangiocarcinoma (CCA) cases to better understand TLR3 signaling and explore the potential therapeutic target in CCA. METHODS: The expression of TLR3 and receptor-interacting protein kinase 1 (RIPK1) in primary CCA tissues was assayed by Immunohistochemical staining and their associations with clinicopathological characteristics and survival data were evaluated. The effects of TLR3 ligand, Poly(I:C) and Smac mimetic, an IAP antagonist on CCA cell death and invasion were determined by cell death detection methods and Transwell invasion assay, respectively. Both genetic and pharmacological inhibition of RIPK1, RIPK3 and MLKL and inhibitors targeting NF-κB and MAPK signaling were used to investigate the underlying mechanisms. RESULTS: TLR3 was significantly higher expressed in tumor than adjacent normal tissues. We demonstrated in a panel of CCA cell lines that TLR3 was frequently expressed in CCA cell lines, but was not detected in a nontumor cholangiocyte. Subsequent in vitro study demonstrated that Poly(I:C) specifically induced CCA cell death, but only when cIAPs were removed by Smac mimetic. Cell death was also switched from apoptosis to necroptosis when caspases were inhibited in CCA cells-expressing RIPK3. In addition, RIPK1 was required for Poly(I:C) and Smac mimetic-induced apoptosis and necroptosis. Of particular interest, high TLR3 or low RIPK1 status in CCA patients was associated with more invasiveness. In vitro invasion demonstrated that Poly(I:C)-induced invasion through NF-κB and MAPK signaling. Furthermore, the loss of RIPK1 enhanced Poly(I:C)-induced invasion and ERK activation in vitro. Smac mimetic also reversed Poly(I:C)-induced invasion, partly mediated by RIPK1. Finally, a subgroup of patients with high TLR3 and high RIPK1 had a trend toward longer disease-free survival (p = 0.078, 28.0 months and 10.9 months). CONCLUSION: RIPK1 plays a pivotal role in TLR3 ligand, Poly(I:C)-induced cell death when cIAPs activity was inhibited and loss of RIPK1 enhanced Poly(I:C)-induced invasion which was partially reversed by Smac mimetic. Our results suggested that TLR3 ligand in combination with Smac mimetic could provide therapeutic benefits to the patients with CCA. Video abstract.

  729. 高齢者の食道癌化学放射線治療後再発に対する光線力学療法の治療成績

    佐藤 千晃, 篠崎 康晴, 植木 俊輔, 福富 俊明, 岡本 宏史, 高屋 快, 谷山 裕亮, 海野 倫明, 亀井 尚

    Gastroenterological Endoscopy　62　(Suppl.2)　2131-2131　2020/10

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  730. 腹腔鏡下大腸切除における回腸人工肛門閉鎖部腹壁瘢痕ヘルニアの発生と危険因子の検討

    梶原 大輝, 初沢 悠人, 小林 実, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 大沼 忍, 林 洋毅, 武者 宏昭, 石田 孝宣, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　81　(増刊)　342-342　2020/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  731. 炎症性腸疾患に対する低侵襲手術の進歩 経肛門操作先行による腹腔鏡補助下大腸全摘・回腸嚢肛門吻合術の治療成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 小林 実, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 武者 宏明, 石田 孝宣, 亀井 尚, 大沼 忍, 海野 倫明

    日本臨床外科学会雑誌　81　(増刊)　213-213　2020/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  732. 各科におけるロボット支援下手術の工夫 直腸悪性腫瘍に対するロボット手術の短期成績

    大沼 忍, 神山 篤史, 唐澤 秀明, 初沢 悠人, 小林 実, 鈴木 秀幸, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 林 洋毅, 武者 宏昭, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　58回　WS23-4　2020/10

    Publisher: (一社)日本癌治療学会

  733. レセルピンアナログはABCG2機能を抑制する

    大沼 忍, 小久保 翔志, 村上 恵, 小林 実, 梶原 大輝, 山村 明寛, 唐澤 秀明, 林 洋毅, 武者 宏昭, 亀井 尚, スレッシュ・アンバドカー, 海野 倫明

    日本癌学会総会記事　79回　OE17-2　2020/10

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  734. 局所進行胃癌に対するS-1+分割投与CDDP併用術前化学療法の有用性

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 木内 誠, 柴田 近, 亀井 尚, 海野 倫明

    日本消化器病学会雑誌　117　(臨増大会)　A774-A774　2020/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  735. 内視鏡的ネクロセクトミー後のWONの再発要因について

    粂 潔, 池田 未緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 海野 倫明, 正宗 淳

    日本消化器病学会雑誌　117　(臨増大会)　A719-A719　2020/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  736. 胆管非拡張型膵・胆管合流異常に合併した若年性胆管癌の1例

    大塚 英郎, 青木 泰孝, 畠 達夫, 益田 邦洋, 水間 正道, 中川 圭, 森川 孝則, 菅野 敦, 正宗 淳, 大森 優子, 古川 徹, 海野 倫明

    胆道　34　(4)　772-780　2020/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  737. 内視鏡的ネクロセクトミー後のWONの再発要因について

    粂 潔, 池田 未緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 海野 倫明, 正宗 淳

    日本消化器病学会雑誌　117　(臨増大会)　A719-A719　2020/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  738. 胆管非拡張型膵・胆管合流異常に合併した若年性胆管癌の1例

    大塚 英郎, 青木 泰孝, 畠 達夫, 益田 邦洋, 水間 正道, 中川 圭, 森川 孝則, 菅野 敦, 正宗 淳, 大森 優子, 古川 徹, 海野 倫明

    胆道　34　(4)　772-780　2020/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  739. 食道切除後の消化管再建 レーザードップラー血流計を用いた再建胃管血流評価の後方視的検討

    福富 俊明, 谷山 裕亮, 高屋 快, 佐藤 千晃, 岡本 宏史, 小関 健, 植木 俊輔, 篠崎 康晴, 海野 倫明, 石田 孝宣, 亀井 尚

    日本臨床外科学会雑誌　81　(増刊)　240-240　2020/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  740. Oxaliplatinによる末梢神経障害に対するアミノ酸シスチン・テアニン経口投与の効果

    小林 実, 佐藤 龍一郎, 市川 英孝, 赤澤 直也, 矢澤 貴, 阿部 友哉, 岡田 恭穂, 柿田 徹也, 及川 昌也, 大沼 忍, 海野 倫明, 土屋 誉

    日本癌治療学会学術集会抄録集　58回　O57-4　2020/10

    Publisher: (一社)日本癌治療学会

  741. Renoportal再建を施行した生体肝移植後挙上空腸静脈瘤から消化管出血を来した一例

    中西 渉, 宮城 重人, 戸子台 和哲, 藤尾 淳, 柏館 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 海野 倫明, 亀井 尚

    移植　55　(総会臨時)　346-346　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  742. 肝移植におけるdnDSAの危険因子と免疫抑制療法再強化によるDSA抑制効果の検証

    戸子台 和哲, 宮城 重人, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 小笠原 弘之, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　240-240　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  743. 高齢ドナー高齢レシピエントの肝移植術後経過における危険性の検討

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　251-251　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  744. 当科のアルコール関連肝不全における肝移植後経過に関する検討

    菖野 佳浩, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 太田 嶺人, 海野 倫明, 亀井 尚

    移植　55　(総会臨時)　278-278　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  745. 急性肝不全昏睡型の肝移植成績および予後不良因子の検討

    宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 柏舘 俊明, 佐々木 健吾, 菖野 佳浩, 太田 嶺人, 亀井 尚, 海野 倫明

    移植　55　(総会臨時)　280-280　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  746. 皮下膵島移植成績向上の基盤となる新規組織内酸素濃度測定方法の開発

    三頭 啓明, 猪村 武弘, 稲垣 明子, Fathi Ibrahim, 宮城 重人, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　55　(総会臨時)　349-349　2020/10

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  747. 膵癌に対する腹腔鏡下膵体尾部切除 Superior approachを用いた膵癌に対する腹腔鏡下膵尾側切除術

    森川 孝則, 石田 晶玄, 高舘 達之, 三浦 孝之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 亀井 尚, 石田 孝宣, 海野 倫明

    日本臨床外科学会雑誌　81　(増刊)　234-234　2020/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  748. 膵・胆管合流異常における胆管非拡張例の術式選択と長期予後 非拡張型膵・胆管合流異常における胆管病変の検討

    大塚 英郎, 畠 達夫, 青木 修一, 三浦 孝之, 前田 晋平, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　81　(増刊)　285-285　2020/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  749. 手術前後に外科医が行う自己学習に関するアンケート調査

    小林 実, 及川 昌也, 土屋 誉, 大沼 忍, 亀井 尚, 海野 倫明

    臨牀と研究　97　(10)　1293-1297　2020/10

    Publisher: 大道学館出版部

    ISSN： 0021-4965

  750. A Gemcitabine Plus 5-Fluorouracil Combination Inhibits Gastric-Cancer Liver Metastasis in a PDOX Model: A Novel Treatment Strategy. International-journal Peer-reviewed

    Norihiko Sugisawa, Hiroto Nishino, Takashi Higuchi, Jun Ho Park, Jun Yamamoto, Yoshihiko Tashiro, Kei Kawaguchi, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Anticancer research　40　(10)　5393-5397　2020/10

    DOI： 10.21873/anticanres.14547 　

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    BACKGROUND/AIM: We established a new patient-derived orthotopic xenograft (PDOX) model of gastric cancer liver metastasis and evaluated the efficacy of a novel combination chemotherapy, gemcitabine (GEM) plus 5-fluorouracil (5-FU), compared to a standard regimen of oxaliplatinum (L-OHP) plus 5-FU on the liver metastasis. MATERIALS AND METHODS: Patient-derived gastric cancer was established in nude mice from the patient' s surgical tumor specimen. A single tumor fragment was implanted in the liver of nude mice. The mice with tumors were treated by GEM plus 5-FU or L-OHP plus 5-FU. RESULTS: GEM plus 5-FU or L-OHP plus 5-FU significantly and similarly inhibited tumor growth on the liver compared to the untreated control (p=0.007, p=0.02, respectively). CONCLUSION: GEM plus 5-FU could be a novel future clinical alternative to L-OHP plus 5-FU in gastric cancer patients who cannot tolerate platinum drugs.

  751. Impact of a board certification system and implementation of clinical practice guidelines for pancreatic cancer on mortality of pancreaticoduodenectomy. Peer-reviewed

    Masamichi Mizuma, Hiroyuki Yamamoto, Hiroaki Miyata, Mitsukazu Gotoh, Michiaki Unno, Tooru Shimosegawa, Yasushi Toh, Yoshihiro Kakeji, Yasuyuki Seto

    Surgery today　50　(10)　1297-1307　2020/10

    DOI： 10.1007/s00595-020-02017-3 　

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    PURPOSES: The aim of this study was to clarify the impact of a board certification system and the implementation of clinical practice guidelines for pancreatic cancer (PC) on the mortality of pancreaticoduodenectomy in Japan. METHODS: By a web questionnaire survey via the National Clinical Database (NCD) for departments participating in the NCD, quality indicators (QIs) related to the treatment for PC, namely the board certification systems of various societies and the adherence to clinical practice guidelines for PC, were investigated between October 2014 and January 2015. A multivariable logistic regression analysis was performed to evaluate the relationship between the QIs and mortality of pancreaticoduodenectomy. RESULTS: Of 1415 departments that registered at least 1 pancreaticoduodenectomy between 2013 and 2014 in NCD, 631 departments (44.6%), which performed pancreaticoduodenectomy for a total of 11,684 cases, answered the questionnaire. The mortality of pancreaticoduodenectomy was positively affected by the board certification systems of the Japanese Society of Gastroenterological Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japanese Society of Gastroenterology, and Japanese Society of Medical Oncology as well as by institutions that used magnetic resonance imaging of ≥ 3 T for the diagnosis of PC in principle. CONCLUSIONS: The measurement of the appropriate QIs is suggested to help improve the mortality in pancreaticoduodenectomy. Masamichi Mizuma and Hiroyuki Yamamoto equally contributed.

  752. The evaluation of the safety and efficacy of intravenously administered allogeneic multilineage-differentiating stress-enduring cells in a swine hepatectomy model. Peer-reviewed

    Masahiro Iseki, Masamichi Mizuma, Shohei Wakao, Yoshihiro Kushida, Katsuyoshi Kudo, Masahiko Fukase, Masaharu Ishida, Tomoyuki Ono, Mitsuhiro Shimura, Ichiro Ise, Yukie Suzuki, Teruko Sueta, Ryuta Asada, Shinobu Shimizu, Yoshiyuki Ueno, Mari Dezawa, Michiaki Unno

    Surgery today　51　(4)　634-650　2020/09/11

    DOI： 10.1007/s00595-020-02117-0 　

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    INTRODUCTION: Multilineage-differentiating stress-enduring (Muse) cells are non-tumorigenic endogenous pluripotent-like cells residing in the bone marrow that exert a tissue reparative effect by replacing damaged/apoptotic cells through spontaneous differentiation into tissue-constituent cells. Post-hepatectomy liver failure (PHLF) is a potentially fatal complication. The main purpose of this study was to evaluate the safety and efficiency of allogeneic Muse cell administration via the portal vein in a swine model of PHLF. METHODS: Swine Muse cells, collected from swine bone marrow-mesenchymal stem cells (MSCs) as SSEA-3(+) cells, were examined for their characteristics. Then, 1 × 107 allogeneic-Muse cells and allogeneic-MSCs and vehicle were injected via the portal vein in a 70% hepatectomy swine model. RESULTS: Swine Muse cells exhibited characteristics comparable to previously reported human Muse cells. Compared to the MSC and vehicle groups, the Muse group showed specific homing of the administered cells into the liver, resulting in improvements in the control of hyperbilirubinemia (P = 0.04), prothrombin international normalized ratio (P = 0.05), and suppression of focal necrosis (P = 0.04). Integrated Muse cells differentiated spontaneously into hepatocyte marker-positive cells. CONCLUSIONS: Allogeneic Muse cell administration may provide a reparative effect and functional recovery in a 70% hepatectomy swine model and thus may contribute to the treatment of PHLF.

  753. Prognostic impact of intraoperative peritoneal cytology after neoadjuvant therapy for potentially resectable pancreatic cancer. International-journal Peer-reviewed

    Shuichi Aoki, Masamichi Mizuma, Hiroki Hayashi, Shingo Yoshimachi, Tatsuo Hata, Takayuki Miura, Tatsuyuki Takadate, Shimpei Maeda, Kyohei Ariake, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　20　(8)　1711-1717　2020/09/10

    DOI： 10.1016/j.pan.2020.08.022 　

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    BACKGROUND: Neoadjuvant therapy (NAT) is considered a potential approach to improve survival for patients with pancreatic adenocarcinoma (PA). The objective of this study was to identify the clinical implications of washing peritoneal cytology (CY) status after NAT. METHODS: Between 2005 and 2016, 151 consecutive patients with resectable (R)/borderline resectable (BR) PA underwent NAT with intention of subsequent resection at our institution. Of them, 13 and 123 patients underwent pancreatectomies with positive (CY+) and negative (CY-) cytology, respectively, while the remaining 15 patients did not undergo resection due to gross metastases at laparotomy. The clinicopathological factors influencing overall survival were clarified by the uni- and multivariate analyses. RESULTS: The postoperative overall survival (OS) and disease-free survival (DFS) were markedly worse in patients who underwent resection with CY+, compared with those who were CY- (median OS, 14.8 m vs 30.8 m, p = 0.026, and median DFS 6.0 m vs 15.1 m, p = 0.008). According to the resectability by NCCN guidelines, CY+ indicates worse prognosis than CY- in R-PA patients (mOS: 30.1 m vs 71.1 m: p = 0.080). Similarly, in BR-PA patients, CY+ showed the significantly worse prognosis than CY- (mOS: 13.8 m vs 24.5 m: p = 0.048), which prognosis is comparable with patients who did not undergo resection. The multivariate analysis revealed that resectability, CY status and the induction of adjuvant therapy were significant predictors of postoperative OS (p = 0.007: Hazard ratio 2.264, 0.040:2.094 and 0.002:3.246, respectively). CONCLUSIONS: CY+ is a significant predictor of poorer prognosis in PA patients after NAT. The subsequent pancreatectomies with CY+ after NAT do not contribute to prolonged survival.

  754. Effects of re-augmenting maintenance immunosuppression on post-transplant donor-specific HLA antibodies in liver transplantation. International-journal Peer-reviewed

    Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Transplant immunology　63　101334-101334　2020/09/09

    DOI： 10.1016/j.trim.2020.101334 　

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    BACKGROUND: Donor-specific antibodies (DSAs) have various negative short- and long-term effects after organ transplantation. DSAs are prevalent in patients with insufficient immunosuppression; thus, even patients with stable conditions after liver transplantation should be under optimized immunosuppression. However, the effect of re-augmenting immunosuppression therapy for patients with insufficient immunosuppression remains unclear. In this study, we investigated the long-term changes and the effects of immunosuppression (IS) re-augmentation on the DSA status. METHODS: Two DSA screenings were performed in 67 patients during long-term follow-up after liver transplantation. After the first screening, IS re-augmentation was performed in patients with consent. The effects of IS re-augmentation on the DSA status were analyzed using data of the serial DSA screenings. Negative conversion was defined as DSA positivity with MFI > 1000 converted to MFI < 1000. Improvement of DSA status was defined as either a 50% reduction of MFI or negative conversion. RESULTS: The median interval between the first and second DSA screening was 50 months. Among 67 patients, 43 were positive for DSAs on the first screening. Among these 43 patients, 30 had minimal to no IS therapy at the time of the first screening. Among the 30 patients, IS re-augmentation was conducted in 19. A comparison between the patients with a re-augmented IS and those with a sustained minimized IS showed that the DSA levels significantly decreased in the former (63% (12/19) vs. 18% (2/11), p = 0.02). CONCLUSIONS: The results of this study indicate that post-liver transplant IS re-augmentation had suppressive effects on the DSA status. However, the clinical significance of DSA-negative conversion and/or mean fluorescence intensity reduction needs to be further investigated through histological evaluation and/or graft survival during longer follow-up periods.

  755. Staging laparoscopy is mandatory for the treatment of pancreatic cancer to avoid missing radiologically negative metastases. Peer-reviewed

    Tatsuyuki Takadate, Takanori Morikawa, Masaharu Ishida, Shuichi Aoki, Tatsuo Hata, Masahiro Iseki, Takayuki Miura, Kyohei Ariake, Shimpei Maeda, Kei Kawaguchi, Kunihiro Masuda, Hideo Ohtsuka, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　51　(5)　686-694　2020/09/08

    DOI： 10.1007/s00595-020-02121-4 　

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    PURPOSE: Staging laparoscopy is considered useful for determining treatment plans for advanced pancreatic cancer. However, the indications for staging laparoscopy are not clear. This study aimed to evaluate the safety of staging laparoscopy and its usefulness for detecting distant metastases in patients with pancreatic cancer. METHODS: A total of 146 patients with pancreatic cancer who underwent staging laparoscopy between 2013 and 2019 were analyzed. Staging laparoscopy was performed in all pancreatic cancer patients in whom surgery was considered possible. RESULTS: In this cohort, 42 patients (29%) were diagnosed with malignant cells on peritoneal lavage cytology, 9 (6%) had peritoneal dissemination, and 11 (8%) had liver metastases. A total of 48 (33%) had radiologically negative metastases. On a multivariate analysis, body and tail cancer [odds ratio (OR) 5.00, 95% confidence interval (CI) 2.15-11.6, p < 0.001], high CA19-9 level [OR 4.04, 95% CI 1.74-9.38, p = 0.001], and a resectability status of unresectable (OR 2.31, 95% CI 1.03-5.20, p = 0.04) were independent risk factors for radiologically negative metastases. CONCLUSIONS: Staging laparoscopy can be safely performed and is useful for the diagnosis of radiologically negative metastases. Staging laparoscopy should be routinely performed for the accurate diagnosis of pancreatic cancer patients before pancreatectomy and/or local treatment, such as radiotherapy.

  756. Epigenetic inactivation of IRX4 is responsible for acceleration of cell growth in human pancreatic cancer. International-journal Peer-reviewed

    Kanchan Chakma, Zhaodi Gu, Yakefujiang Abudurexiti, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Horii, Shinichi Fukushige

    Cancer science　111　(12)　4594-4604　2020/09/07

    DOI： 10.1111/cas.14644 　

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    Epigenetic gene silencing by aberrant DNA methylation is one of the important mechanisms leading to loss of key cellular pathways in tumorigenesis. Methyl-CpG targeted transcriptional activation (MeTA) reactivates hypermethylation-mediated silenced genes in a different way from DNA demethylating agents. Microarray coupled with MeTA (MeTA-array) identified seven commonly hypermethylation-mediated silenced genes in 12 pancreatic ductal adenocarcinoma (PDAC) cell lines. Among these, we focused on IRX4 (Iroquois homeobox 4) because IRX4 is located at chromosome 5p15.33 where one of PDAC susceptibility loci has been identified through genome-wide association study. IRX4 was greatly downregulated in all of the analyzed 12 PDAC cell lines by promoter hypermethylation. In addition, the IRX4 promoter region was found to be frequently and specifically hypermethylated in primary resected PDACs (18/28: 64%). Re-expression of IRX4 inhibited colony formation and proliferation in two PDAC cell lines, PK-1 and PK-9. In contrast, knockdown of IRX4 accelerated cell proliferation in an IRX4-expressing normal pancreatic ductal epithelial cell line, HPDE-1. Because IRX4 is a sequence-specific transcription factor, downstream molecules of IRX4 were pursued by microarray analyses utilizing tetracycline-mediated IRX4 inducible PK-1 and PK-9 cells; CRYAB, CD69, and IL32 were identified as IRX4-downstream candidate genes. Forced expression of these genes suppressed colony formation abilities for both PK-1 and PK-9. These results suggest that DNA methylation-mediated silencing of IRX4 contributes to pancreatic tumorigenesis through aberrant transcriptional regulation of several cancer-related genes.

  757. 遺伝性大腸癌の診療 家族性大腸腺腫症の外科的治療の長期成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 小林 実, 初沢 悠人, 大沼 忍, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　73　(9)　A78-A78　2020/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  758. 潰瘍性大腸炎術後のストーマ関連腸閉塞 術式とストーマサイトに着目して

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 武者 宏昭, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　73　(9)　A147-A147　2020/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  759. 腸管不全の予防を企図したクローン病に対する術式選択

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 梶原 大輝, 小林 実, 初沢 悠人, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　73　(9)　A203-A203　2020/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  760. 直腸神経内分泌腫瘍に対する内視鏡治療症例における追加切除の妥当性の検討

    大沼 忍, 初沢 悠人, 小林 実, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 西條 文人, 武者 宏昭, 亀井 尚, 海野 倫明

    日本大腸肛門病学会雑誌　73　(9)　A153-A153　2020/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  761. BCLC BのHCCに対する肝切除術の長期成績

    中西 渉, 宮城 重人, 戸子台 和哲, 藤尾 淳, 柏館 俊明, 菖野 佳浩, 亀井 尚, 海野 倫明

    肝臓　61　(Suppl.2)　A645-A645　2020/09

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  762. 【肝胆膵外科におけるConversion Surgery】総論 Conversion Surgeryの意義 外科医の立場から

    中川 圭, 元井 冬彦, 海野 倫明

    手術　74　(10)　1407-1412　2020/09

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  763. 【胆嚢癌外科診療は進歩したか-現状と問題点-】胆道癌補助療法の現状と展望

    青木 修一, 中川 圭, 益田 邦洋, 森川 孝則, 海野 倫明

    胆と膵　41　(9)　889-895　2020/09

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  764. 【内分泌腺腫瘍(第2版)-基礎・臨床研究のアップデート-】膵神経内分泌腫瘍 膵癌との鑑別診断

    三浦 孝之, 青木 豪, 海野 倫明

    日本臨床　78　(増刊4 内分泌腺腫瘍)　737-742　2020/09

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  765. Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model. International-journal Peer-reviewed

    Norihiko Sugisawa, Kazuyuki Hamada, Qinghong Han, Jun Yamamoto, Y U Sun, Hiroto Nishino, Kei Kawaguchi, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Anticancer research　40　(9)　4869-4874　2020/09

    DOI： 10.21873/anticanres.14489 　

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    BACKGROUND/AIM: In the present study, we evaluated the efficacy of adjuvant administration of oral recombinant methioninase (o-rMETase) against recurrence and metastasis in a 4T1 murine breast-cancer syngeneic model. MATERIALS AND METHODS: 4T1 cells were orthotopically implanted into the 2nd mammary fat pad of BALB/c mice. The 4T1 orthotopic syngeneic models were randomized into 2 groups after primary tumor resection: untreated control and o-rMETase (100 units, oral, daily, 2 weeks). RESULTS: The frequency and extent of local recurrence were reduced by o-rMETase. The number of individual cancer cells and metastatic nodules on the lung surface was significantly lower in the o-rMETase-treated mice than the untreated control mice. CONCLUSION: Adjuvant o-rMETase inhibited local recurrence and lung metastasis after primary tumor resection.

  766. Focal Parenchymal Atrophy and Fat Replacement Are Clues for Early Diagnosis of Pancreatic Cancer with Abnormalities of the Main Pancreatic Duct. Peer-reviewed

    Shin Miura, Kiyoshi Kume, Kazuhiro Kikuta, Shin Hamada, Tetsuya Takikawa, Naoki Yoshida, Seiji Hongo, Yu Tanaka, Ryotaro Matsumoto, Takanori Sano, Mio Ikeda, Toru Furukawa, Masahiro Iseki, Michiaki Unno, Atsushi Masamune

    The Tohoku journal of experimental medicine　252　(1)　63-71　2020/09

    DOI： 10.1620/tjem.252.63 　

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    Pancreatic cancer is one of the most dangerous solid tumors, but its early diagnosis is difficult. The abnormality of the main pancreatic duct (MPD), such as a single localized stricture and upstream dilatation, might be useful in the early detection of pancreatic cancer. However, these findings are often observed in benign inflammatory cases. This study aimed to clarify whether early pancreatic cancer presenting MPD abnormalities has characteristic features different from those of benign cases. This is a single-center, retrospective study. We analyzed 20 patients who underwent pancreatectomy presenting with a single, localized MPD stricture without identifiable masses on imaging: 10 patients with pancreatic ductal adenocarcinoma (cancer group; 6 with stage 0 and 4 with stage I) and 10 patients with benign strictures (benign group; 8 with inflammation and 2 with low-grade pancreatic intraepithelial neoplasms). Pancreatectomy was performed in these benign cases because high-grade intraepithelial neoplasm was suspected. Although the proportion of patients with diabetes mellitus tended to be higher in the cancer group (6/10) than that in the benign group (1/10) (P = 0.058), other clinical characteristics were not different between the groups. Preoperative cytological malignancies were detected in four patients in the cancer group (4/10) but not in the benign group (P = 0.09). Focal parenchymal atrophy and fat replacement were more frequently detected on computed tomography in the cancer group (7/10) than in the benign group (1/10) (P = 0.02). In conclusion, focal parenchymal atrophy and fat replacement may provide clues for the early diagnosis of pancreatic cancer.

  767. An integrated analysis of host- and tumor-derived markers for predicting high-grade dysplasia and associated invasive carcinoma of intraductal papillary mucinous neoplasms of the pancreas. Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Takanori Morikawa, Kei Nakagawa, Hiroki Hayashi, Atsushi Kanno, Atsushi Masamune, Takashi Kamei, Takeshi Naitoh, Toru Furukawa, Michiaki Unno

    Surgery today　50　(9)　1039-1048　2020/09

    DOI： 10.1007/s00595-020-01982-z 　

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    PURPOSE: To clarify the usefulness of cancer-related inflammation, hypermetabolism, and subsequent host malnutrition biomarkers for predicting the histological grades of intraductal papillary mucinous neoplasms of the pancreas (IPMNs). METHODS: The systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and maximum standardized uptake value (SUVmax) on fluorodeoxyglucose-positron emission tomography were compared across 171 resected IPMN cases of different histological grades. The diagnostic performance of each marker and of their combinations for predicting IPMN with high-grade dysplasia (HGD)/associated invasive carcinoma (INV) was also tested. RESULTS: Of the 171 IPMNs, the IPMN cases with HGD showed significantly higher values of SII (median 406 vs. 340; P = 0.041) and SUVmax (median 2.5 vs. 2.0; P = 0.001) than those with low-grade dysplasia (LGD). On a multivariate analysis, the SII and SUVmax were both independent markers for predicting HGD/INV. A combination analysis including the tumor- and host-derived markers in combination with imaging findings showed an improved diagnostic performance (area under the curve 0.824; sensitivity 75.9%; specificity 80.0%). CONCLUSIONS: The combination of multiple markers of host-derived inflammation and tumor-derived focal hypermetabolism can serve as a predictor for the presence of HGD/INV.

  768. Per-oral endoscopic myotomy (POEM) for a sigmoid type of achalasia: short-term outcomes and changes in the esophageal angle. International-journal Peer-reviewed

    Shota Maruyama, Yusuke Taniyama, Tadashi Sakurai, Makoto Hikage, Chiaki Sato, Kai Takaya, Takuro Konno, Takeshi Naitoh, Michiaki Unno, Takashi Kamei

    Surgical endoscopy　34　(9)　4124-4130　2020/09

    DOI： 10.1007/s00464-019-07180-4 　

    ISSN： 0930-2794

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    BACKGROUND: Per-oral endoscopic myotomy (POEM) is an endoscopic procedure whereby the esophageal muscle is incised in order to lower the lower esophageal sphincter (LES) pressure. Since the time it was first performed in 2008 and subsequently reported on in 2010 by Inoue et al., POEM has been shown to be safe and effective for straight type of achalasia. On the other hand, the efficacy of POEM had been controversial for patients with achalasia of the sigmoid type, in which a high LES pressure is accompanied by morphological changes, including dilation, acute angulation, and rotation. The aim of this study is to evaluate the safety and efficacy of POEM in patients with sigmoid type of achalasia. METHODS: Between May 2015 and December 2017, 16 patients with a sigmoid type of achalasia underwent POEM in our institute. The POEM procedure was the same as that for the straight type of achalasia. The double-scope technique was used to check the distal end of the submucosal tunnel from the gastric side. The primary endpoint was improvement of Eckardt score at 2 months after POEM. The secondary endpoints comprised operating time, change in the esophageal angulation, and adverse events. RESULTS: All patients underwent POEM without severe adverse events. The respective parameters before and after POEM significantly differed in terms of mean (SD) Eckardt score [4.9 (2.0) vs. 0.4 (0.6), p < 0.01], LES pressure [19.4 (10.2) vs. 9.2 (6.4), p < 0.01], and integrated relaxation pressure [17.6 (9.2) vs. 7.9 (5.5), p < 0.01]. The average operation time was 94.7 ± 31.4 min. The average esophageal angulation was 88.4° ± 23.1° before POEM and 109.5° ± 16.7° after POEM (p < 0.01). Four patients had postoperative complications that were treated conservatively. CONCLUSIONS: POEM can improve both LES pressure and esophageal angulation in patients with sigmoid achalasia.

  769. Efficacy and Safety of Low-Molecular-Weight Heparin on Prevention of Venous Thromboembolism after Laparoscopic Operation for Gastrointestinal Malignancy in Japanese Patients: A Multicenter, Open-Label, Prospective, Randomized Controlled Trial. International-journal Peer-reviewed

    Tamotsu Obitsu, Naoki Tanaka, Atsushi Oyama, Tatsuya Ueno, Masaaki Saito, Takuhiro Yamaguchi, Airi Takagi, Toshiki Rikiyama, Michiaki Unno, Takeshi Naitoh

    Journal of the American College of Surgeons　231　(5)　501-509　2020/08/19

    DOI： 10.1016/j.jamcollsurg.2020.08.734 　

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    BACKGROUND: The risk of venous thromboembolism (VTE) after surgery for malignancy in Japanese patients is unclear; therefore, standard prevention protocols have not been established, especially for minimally invasive procedures. We aimed to investigate the additional effect of low molecular weight heparin (LMWH) on prevention of VTE after laparoscopic surgery for gastrointestinal malignancy. STUDY DESIGN: From February 2013 to January 2017, 400 patients scheduled for laparoscopic surgery were included. Cases were randomly allocated to the physical therapy group (Control group; 201 patients) or to the combination-therapy group (LMWH group; 199 patients), in which enoxaparin sodium (20 mg [= 2000 IU] twice a day) was administered for 1 week postoperatively in addition to the physical therapy. A diagnosis of VTE was made by contrast-enhanced CT or ultrasonography when symptomatic or D-dimer was ≥10 μg/mL. RESULTS: VTE was observed in 1.2% and 4.0% of patients in the LMWH and Control groups, respectively (odds ratio [OR] 0.3, 95% confidence interval [CI] 0.03-1.53). Pulmonary embolism was confirmed only in the Control group (1.7%). No major bleeding occurred in either group. Logistic multiple regression analysis revealed that surgical time extension (OR 1.02, 95% CI 1.00-1.04) was a risk factor of VTE, while administration of LMWH (OR 0.21, 95% CI 0.03-0.99), male sex (OR 0.12, 95% CI 0.01-0.60), and early cancer (OR 0.17, 95% CI 0.02-0.82) reduced the risk of VTE. CONCLUSIONS: Postoperative LMWH administration is safe. The additional effect of LMWH administration on the physical therapy was not statistically proven in this study. However, it could be useful for the patients with risk factors such as female sex, long operation time, and higher cancer stage.

  770. Liver resections in patients with prior bilioenteric anastomosis are predisposed to develop organ/space surgical site infections and biliary leakage: results from a propensity score matching analysis. Peer-reviewed

    Takanori Morikawa, Masaharu Ishida, Masahiro Iseki, Shuichi Aoki, Tatsuo Hata, Kei Kawaguchi, Hideo Ohtsuka, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takashi Kamei, Michiaki Unno

    Surgery today　51　(4)　526-536　2020/08/12

    DOI： 10.1007/s00595-020-02105-4 　

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    PURPOSE: The aims of this study were to compare the perioperative outcomes after hepatectomy with prior bilioenteric anastomosis to those without prior anastomosis, and to elucidate the mechanisms and preventative measures of its characteristic complications. METHODS: The demographic data and perioperative outcomes of 525 hepatectomies performed between January 2007 and December 2018, including 40 hepatectomies with prior bilioenteric anastomosis, were retrospectively analyzed. RESULTS: A propensity score matching analysis demonstrated that hepatectomies with prior bilioenteric anastomosis were associated with a higher frequency of major complications (p = 0.015), surgical site infection (p = 0.005), organ/space surgical site infection (p = 0.003), and bile leakage (p = 0.007) compared to those without. A multivariate analysis also elucidated that prior bilioenteric anastomosis was one of the independent risk factors of organ/space surgical site infection. In the patients with prior bilioenteric anastomosis, bile leakage was associated with organ/space surgical site infection at a significantly higher rate than those without prior bilioenteric anastomosis (p < 0.001). CONCLUSIONS: Prior bilioenteric anastomosis is a strong risk factor for organ/space surgical site infections, which might be induced by bile leakage. To prevent infectious complications after hepatectomy with prior bilioenteric anastomosis, meticulous liver transection to reduce bile leakage rate is thus considered to be mandatory.

  771. Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid. Peer-reviewed

    Masashi Saito, Kiyotaka Asanuma, Waku Hatta, Tomoyuki Koike, Tatsuo Hata, Fumiyoshi Fujishima, Toru Furukawa, Michiaki Unno, Atsushi Masamune

    Internal medicine (Tokyo, Japan)　59　(23)　3001-3007　2020/08/04

    DOI： 10.2169/internalmedicine.4548-20 　

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    A 38-year-old Japanese man who had been diagnosed with appendiceal carcinoid and undergone ileocecal resection 8 years before, presented with duodenal obstruction caused by a submucosal tumor-like appearance. He was diagnosed with long-term recurrence of appendiceal goblet cell carcinoid (GCC) with a multi-morphological pattern based on the histological assessment of a duodenal biopsy and his previously resected appendix. He underwent subtotal stomach-preserving pancreaticoduodenectomy combined with resection of an ileo-colic anastomotic lesion. The GCC recurred at the nearby ileo-colic anastomosis and invaded the duodenum. This late recurrence might have resulted from the unique features of his GCC, which contained cells with different degrees of malignancy.

  772. 幽門側胃切除後に発症した食道アカラシアに対して経口内視鏡的筋層切開術(POEM)を施行した1例

    安藤 涼平, 佐藤 千晃, 今野 裕司, 氏家 直人, 鳩山 恵一朗, 及川 隆洋, 福富 俊明, 高屋 快, 岡本 宏史, 谷山 裕亮, 海野 倫明, 亀井 尚

    Gastroenterological Endoscopy　62　(Suppl.1)　1274-1274　2020/08

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  773. 食道運動機能障害を疑われ、最終的にPlummer-Vinson症候群と診断した1例

    今野 裕司, 佐藤 千晃, 谷山 裕亮, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 氏家 直人, 鳩山 恵一朗, 安藤 涼平, 海野 倫明, 亀井 尚

    Gastroenterological Endoscopy　62　(Suppl.1)　1297-1297　2020/08

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  774. 非切除胆道癌に対する集学的治療-切除可能性評価とConversion Surgery- 肝門部胆管癌の短期・長期成績からみたConversion surgeryの課題

    青木 修一, 中川 圭, 海野 倫明

    胆道　34　(3)　385-385　2020/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  775. 肝門部領域胆管癌の切除境界例とは 肝門部領域胆管癌の術前因子から切除可能境界胆管癌の候補因子を同定する

    益田 邦洋, 中川 圭, 海野 倫明

    胆道　34　(3)　367-367　2020/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  776. 切除後異時性胆管癌に対し外科的切除を行った11例の検討

    齋藤 雄佑, 青木 修一, 中川 圭, 高館 達之, 大森 優子, 益田 邦洋, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 海野 倫明

    胆道　34　(3)　569-569　2020/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  777. 食道胃接合部癌の手術-アプローチ法・郭清範囲・再建術式のdecision making- 食道胃接合部癌に対するリンパ節至適郭清範囲の検討(Study on optimal lymph node dissection range for esophagogastric junction cancer)

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 高屋 快, 福富 俊明, 及川 隆洋, 今野 卓朗, 氏家 直人, 小関 健, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　120回　PD-3　2020/08

    Publisher: (一社)日本外科学会

  778. 再生医療の実現-外科医に期待される役割- ブタ70%肝切除モデルに対する経門脈同種Muse細胞移植

    伊関 雅裕, 水間 正道, 深瀬 正彦, 小野 智之, 志村 充広, 鈴木 ゆき恵, 伊勢 一郎, 石田 晶玄, 工藤 克昌, 林 洋毅, 元井 冬彦, 若尾 昌平, 串田 良祐, 亀井 尚, 石田 孝宣, 内藤 剛, 出澤 真理, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　WS-2　2020/08

    Publisher: (一社)日本外科学会

  779. 血行再建を伴う進行癌切除術の手術手技【Video】動脈合併切除再建を伴う局所進行肝胆膵癌における、安全性向上に向けた当科の挑戦

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　WS-5　2020/08

    Publisher: (一社)日本外科学会

  780. 膵頭十二指腸切除術後膵液瘻リスクスコアの比較検討

    前田 晋平, 畠 達夫, 青木 修一, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  781. メチオニンを標的とした膵癌栄養療法戦略の可能性

    川口 桂, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, Robert Hoffman, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-2　2020/08

    Publisher: (一社)日本外科学会

  782. 膵癌Conversion surgeryにおける術前治療期間の栄養状態の変化が予後に与える影響

    國米 崇, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  783. トリプルネガティブ乳癌におけるグルココルチコイドシグナルの意義に関する検討 アンドロゲンシグナルとの相互作用

    金井 綾子, May Mcnamara Keely, 岩渕 英里奈, 三木 康宏, 小野寺 好明, Fouzia Guestini, Freeha Khalid, 相良 安昭, 大井 恭代, 雷 哲明, 山口 倫, 田中 眞紀, 宮下 穣, 内藤 剛, 海野 倫明, 亀井 尚, 笹野 公伸, 石田 孝宣

    日本外科学会定期学術集会抄録集　120回　SF-1　2020/08

    Publisher: (一社)日本外科学会

  784. Barrett食道癌におけるSerem- and glucocorticoid-induced kinase 1(SGK1)の予後因子としての有用性

    郷右近 祐介, 藤島 史喜, 谷山 裕亮, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚, 笹野 公伸

    日本外科学会定期学術集会抄録集　120回　SF-4　2020/08

    Publisher: (一社)日本外科学会

  785. 腹腔洗浄細胞診陽性膵癌に対して非手術療法を第一選択とした際の予後解析について

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  786. 切除可能膵癌に対する審査腹腔鏡の適応と意義

    高舘 達之, 森川 孝則, 石田 晶玄, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  787. 高分化膵神経内分泌腫瘍(PanNEN)術後再発予測としての全身炎症反応性マーカーの有用性に関する検討

    三浦 孝之, 青木 豪, 大塚 英郎, 畠 達夫, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 昌玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 笹野 公伸, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  788. 先天性胆道拡張症術後合併症からみた肝臓側胆管切除範囲の検討

    大塚 英郎, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  789. 浸潤性膵管癌におけるCD109の造腫瘍性と遠隔転移への関わり

    初沢 悠人, 山口 壹範, 水間 正道, 青木 修一, 畠 達夫, 伊関 雅裕, 川口 桂, 高舘 達之, 青木 豪, 元井 冬彦, 内藤 剛, 亀井 尚, 菅村 和夫, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-1　2020/08

    Publisher: (一社)日本外科学会

  790. 腹腔鏡手術後における静脈血栓塞栓症予防に対する低分子量ヘパリン(Enoxaparin Sodium)の有効性についての多施設共同無作為化比較試験NEXTSURG 012-001

    田中 直樹, 小櫃 保, 小山 淳, 上野 達也, 島村 弘宗, 須藤 剛, 西條 文人, 山内 淳一郎, 三浦 康, 力山 敏樹, 海野 倫明, 内藤 剛

    日本外科学会定期学術集会抄録集　120回　SF-1　2020/08

    Publisher: (一社)日本外科学会

  791. 肝門部領域胆管癌の治療戦略

    中川 圭, 益田 邦洋, 青木 修一, 伊関 雅裕, 高舘 達之, 大塚 英郎, 畠 達夫, 三浦 孝之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  792. 膵癌肝転移に対する外科的切除の意議

    水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 高舘 達之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  793. 胆管内乳頭状腫瘍(IPNB)は臨床病理学的因子および分子異常と関連した2つのTypeに分けられる

    青木 泰孝, 水間 正道, 畠 達夫, 青木 豪, 大森 優子, 小野 裕介, 水上 裕輔, 海野 倫明, 古川 徹

    胆道　34　(3)　498-498　2020/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  794. 東北地方における地域の夜間・休日救急診療での外科医の役割と課題

    濱中 洋平, 多田 寛, 赤松 大二朗, 石井 正, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　120回　SP-8　2020/08

    Publisher: (一社)日本外科学会

  795. 乳癌におけるアミノ酸代謝の重要性と新規治療標的としての可能性

    佐藤 未来, 原田 成美, 宮下 穰, 甘利 正和, 蘇我 朋義, 鈴木 貴, 内藤 剛, 海野 倫明, 亀井 尚, 笹野 公伸, 石田 孝宣

    日本外科学会定期学術集会抄録集　120回　DP-3　2020/08

    Publisher: (一社)日本外科学会

  796. メタボロミクスを用いたAI耐性乳癌の代謝特性の解明

    原田 成美, 佐藤 未来, 多田 寛, 宮下 穰, 濱中 洋平, 江幡 明子, 中川 紗紀, 曽我 朋義, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  797. 炎症性腸疾患に対する手術-タイミング・アプローチ法・再建術式のポイント-【Video】クローン病に対する狭窄形成術および新吻合法の手術手技と術式選択

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 梶原 大輝, 唐澤 秀明, 大沼 忍, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　PD-3　2020/08

    Publisher: (一社)日本外科学会

  798. 上部消化管機能温存術式のエビデンス 高齢者における腹腔鏡補助下噴門側胃切除術の治療成績

    武者 宏昭, 梶原 大輝, 井本 博文, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 青木 豪, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　WS-4　2020/08

    Publisher: (一社)日本外科学会

  799. 3DCGソフトBlenderを用いた腸管の縫合・吻合のシミュレーション

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 大沼 忍, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-8　2020/08

    Publisher: (一社)日本外科学会

  800. 直腸癌局所再発に対する手術療法と術前放射線療法の意義

    大沼 忍, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  801. 胃癌に対する腹腔鏡下幽門側胃切除における左副肝動脈への対処

    青木 豪, 武者 宏昭, 田中 直樹, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-4　2020/08

    Publisher: (一社)日本外科学会

  802. 一時的人工肛門閉鎖部における腹壁瘢痕ヘルニアの発生と危険因子の検討

    梶原 大輝, 大沼 忍, 唐澤 秀明, 神山 篤史, 鈴木 秀幸, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  803. 十二指腸空腸バイパス術後の胆膵路における胆汁酸吸収機序の解明

    上野 知尭, 田中 直樹, 井本 博文, 前川 正充, 市川 英孝, 小野 翼, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本外科学会定期学術集会抄録集　120回　SF-2　2020/08

    Publisher: (一社)日本外科学会

  804. 進行胃癌に対する腹腔鏡下幽門側胃切除術の安全性および根治性

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-4　2020/08

    Publisher: (一社)日本外科学会

  805. 潰瘍性大腸炎に対する腹腔鏡手術の進歩

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 大沼 忍, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-2　2020/08

    Publisher: (一社)日本外科学会

  806. 抗癌剤耐性ABCトランスポーターに対する新規抑制剤の同定と抗癌剤感受性への影響

    小久保 翔志, 大沼 忍, 鈴木 秀幸, 梶原 大輝, 村上 恵, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 佐藤 圭佑, 杉沢 徳彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-1　2020/08

    Publisher: (一社)日本外科学会

  807. 切除困難局所進行大腸癌(左側・RAS野生型)に対する抗EGFR抗体併用化学療法を用いた術前治療戦略

    唐澤 秀明, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-4　2020/08

    Publisher: (一社)日本外科学会

  808. 切除可能膵癌の治療戦略-術前治療 vs 切除先行-【術前治療】切除可能膵癌に対する術前化学療法は標準治療となり得るか? Prep-02/JSAP-05臨床第II/III相試験結果より

    和田 慶太, 海野 倫明, 元井 冬彦, 松山 裕, 里井 壯平, 松本 逸平, 青笹 季史, 白川 博文, 藤井 努, 吉富 秀幸, 高橋 進一郎, 庄 雅之, 上野 秀樹, 小菅 智男

    日本外科学会定期学術集会抄録集　120回　DB-1　2020/08

    Publisher: (一社)日本外科学会

  809. 食道癌集学的治療における放射線治療と外科手術の役割と共存への工夫

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 高屋 快, 福富 俊明, 内藤 剛, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　120回　SF-8　2020/08

    Publisher: (一社)日本外科学会

  810. Barrett食道癌におけるSerem- and glucocorticoid-induced kinase 1(SGK1)の予後因子としての有用性

    郷右近 祐介, 藤島 史喜, 谷山 裕亮, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚, 笹野 公伸

    日本外科学会定期学術集会抄録集　120回　SF-4　2020/08

    Publisher: (一社)日本外科学会

  811. 高分化膵神経内分泌腫瘍(PanNEN)術後再発予測としての全身炎症反応性マーカーの有用性に関する検討

    三浦 孝之, 青木 豪, 大塚 英郎, 畠 達夫, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 昌玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 笹野 公伸, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  812. 膵頭十二指腸切除術後膵液瘻リスクスコアの比較検討

    前田 晋平, 畠 達夫, 青木 修一, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  813. メチオニンを標的とした膵癌栄養療法戦略の可能性

    川口 桂, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, Robert Hoffman, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-2　2020/08

    Publisher: (一社)日本外科学会

  814. 膵癌Conversion surgeryにおける術前治療期間の栄養状態の変化が予後に与える影響

    國米 崇, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  815. 膵癌における術前補助療法後の腹腔洗浄細胞診が予後に与える影響

    青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  816. 血管内皮機能検査であるFMD検査と胆管癌手術における周術期動脈合併症の関連性

    益田 邦洋, 中川 圭, 高舘 達之, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-3　2020/08

    Publisher: (一社)日本外科学会

  817. 腹腔洗浄細胞診陽性膵癌に対して非手術療法を第一選択とした際の予後解析について

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  818. 切除可能膵癌に対する審査腹腔鏡の適応と意義

    高舘 達之, 森川 孝則, 石田 晶玄, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  819. 先天性胆道拡張症術後合併症からみた肝臓側胆管切除範囲の検討

    大塚 英郎, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  820. 局所進行切除不能膵癌に対する腫瘍マーカーを指標とした集学的外科治療戦略

    元井 冬彦, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 内藤 剛, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-1　2020/08

    Publisher: (一社)日本外科学会

  821. 80歳以上の超高齢者における術前栄養指標からみた膵癌手術成績

    森川 孝則, 元井 冬彦, 水間 正道, 伊関 雅裕, 青木 修一, 畠 達夫, 高舘 達之, 三浦 孝之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　SF-5　2020/08

    Publisher: (一社)日本外科学会

  822. 膵癌においてRal GTPase-activating protein(RalGAP)の発現低下は腫瘍形成や浸潤・転移能を促進する

    吉町 信吾, 大塚 英郎, 白川 龍太郎, 高 攀, 坂田 菜摘, 後藤 孝太, 宮崎 健人, Trinh Duc Anh, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明, 堀内 久徳

    日本外科学会定期学術集会抄録集　120回　SF-7　2020/08

    Publisher: (一社)日本外科学会

  823. 肝門部領域胆管癌の治療戦略

    中川 圭, 益田 邦洋, 青木 修一, 伊関 雅裕, 高舘 達之, 大塚 英郎, 畠 達夫, 三浦 孝之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  824. 膵癌肝転移に対する外科的切除の意議

    水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 高舘 達之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  825. 胆嚢癌におけるCancer Associated Fibroblastsの役割

    佃 和彦, 海野 倫明, 内藤 剛, 亀井 尚, 石田 孝宣, 大塚 英郎, 石田 晶玄, 益田 邦洋, 有明 恭平, 三浦 孝之, 元井 冬彦, 林 洋毅, 森川 孝則, 中川 圭, 水間 正道, 吉町 信吾, 三田地 克昂, 宮崎 健人

    日本外科学会定期学術集会抄録集　120回　DP-1　2020/08

    Publisher: (一社)日本外科学会

  826. 十二指腸乳頭部癌における膵頭十二指腸切除膵空腸吻合術の安全性の検討 Blumgart変法は従来法に比べて膵液瘻を減らすのか?

    柏木 良介, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-4　2020/08

    Publisher: (一社)日本外科学会

  827. 当科で切除したSolid Pseudopapillary Neoplasm of the pancreas 23例の検討

    海野 裕一郎, 青木 修一, 森川 孝則, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-5　2020/08

    Publisher: (一社)日本外科学会

  828. 膵癌に対する膵頭十二指腸切除後の炎症反応が予後に与える影響

    畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 伊関 雅裕, 三浦 孝之, 前田 晋平, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　120回　DP-7　2020/08

    Publisher: (一社)日本外科学会

  829. 食道胃接合部癌の手術-アプローチ法・郭清範囲・再建術式のdecision making- 食道胃接合部癌に対するリンパ節至適郭清範囲の検討(Study on optimal lymph node dissection range for esophagogastric junction cancer)

    岡本 宏史, 谷山 裕亮, 佐藤 千晃, 高屋 快, 福富 俊明, 及川 隆洋, 今野 卓朗, 氏家 直人, 小関 健, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　120回　PD-3　2020/08

    Publisher: (一社)日本外科学会

  830. 進行食道癌・胃癌に対する内視鏡外科手術の治療成績と適応限界 cStageII/III進行食道癌に対する側臥位・腹臥位胸腔鏡下食道切除術の治療成績に関する検討

    高屋 快, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 今野 卓朗, 氏家 直人, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　120回　WS-7　2020/08

    Publisher: (一社)日本外科学会

  831. 照射後局所進行食道癌に対する胸腔鏡下salvage食道切除の際に留意すべき気管・気管支との剥離操作のポイントと血流保持の工夫

    福富 俊明, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 及川 隆洋, 氏家 直人, 内藤 剛, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　120回　DP-6　2020/08

    Publisher: (一社)日本外科学会

  832. 【膵癌治療の最前線】切除企図膵癌に対する術前治療 Peer-reviewed

    元井 冬彦, 海野 倫明

    外科　82　(9)　909-914　2020/08

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  833. 【胆膵疾患 胆膵疾患の実地診療Up-to-date】切除可能膵癌に対する術前化学療法 Peer-reviewed

    元井 冬彦, 海野 倫明

    Medical Practice　37　(8)　1260-1262　2020/08

    Publisher: (株)文光堂

    ISSN： 0910-1551

  834. 【肝胆膵における結石診療のベストプラクティス】膵石症 膵石に対する外科的治療 Message from surgeon Peer-reviewed

    石田 晶玄, 大塚 英郎, 海野 倫明

    肝・胆・膵　81　(2)　387-392　2020/08

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  835. ICG蛍光法で血流評価し膵頭十二指腸切除術を行った食道癌術後膵腫瘍の1例 Peer-reviewed

    三頭 啓明, 西村 隆一, 宮城 重人, 元井 冬彦, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　81　(8)　1604-1610　2020/08

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  836. COVID-19: clinical issues from the Japan Surgical Society. Peer-reviewed

    Masaki Mori, Norihiko Ikeda, Akinobu Taketomi, Yo Asahi, Yoshio Takesue, Tatsuya Orimo, Minoru Ono, Takashi Kuwayama, Seigo Nakamura, Yohei Yamada, Tatsuo Kuroda, Kenji Yuzawa, Taizo Hibi, Hiroaki Nagano, Michiaki Unno, Yuko Kitagawa

    Surgery today　50　(8)　794-808　2020/08

    DOI： 10.1007/s00595-020-02047-x 　

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    In this unprecedented COVID-19 pandemic, several key issues must be addressed to ensure safe treatment and prevent rapid spread of the virus and a consequential medical crisis. Careful evaluation of a patient's condition is crucial for deciding the triage plan, based on the status of the disease and comorbidities. As functionality of the medical care system is greatly affected by the environmental situation, the treatment may differ according to the medical and infectious disease circumstances of the institution. Importantly, all medical staff must prevent nosocomial COVID-19 by minimizing the effects of aerosol spread and developing diagnostic and surgical procedures. Polymerase chain reaction (PCR) screening for COVID-19 infection, particularly in asymptomatic patients, should be encouraged as these patients are prone to postoperative respiratory failure. In this article, the Japan Surgical Society addresses the general principles of surgical treatment in relation to COVID-19 infection and advocates preventive measures against viral transmission during this unimaginable COVID-19 pandemic.

  837. Global Survey on Pancreatic Surgery During the COVID-19 Pandemic. International-journal Peer-reviewed

    Atsushi Oba, Thomas F Stoop, Matthias Löhr, Thilo Hackert, Nicholas Zyromski, William H Nealon, Michiaki Unno, Richard D Schulick, Mohammed H Al-Musawi, Wenming Wu, Yupei Zhao, Sohei Satoi, Christopher L Wolfgang, Mohammad Abu Hilal, Marc G Besselink, Marco Del Chiaro

    Annals of surgery　272　(2)　e87-e93　2020/08

    DOI： 10.1097/SLA.0000000000004006 　

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    OBJECTIVE: The aim of this study was to clarify the role of pancreatic surgery during the COVID-19 pandemic to optimize patients' and clinicians' safety and safeguard health care capacity. SUMMARY BACKGROUND DATA: The COVID-19 pandemic heavily impacts health care systems worldwide. Cancer patients appear to have an increased risk for adverse events when infected by COVID-19, but the inability to receive oncological care seems may be an even larger threat, particularly in case of pancreatic cancer. METHODS: An online survey was submitted to all members of seven international pancreatic associations and study groups, investigating the impact of the COVID-19 pandemic on pancreatic surgery using 21 statements (April, 2020). Consensus was defined as >80% agreement among respondents and moderate agreement as 60% to 80% agreement. RESULTS: A total of 337 respondents from 267 centers and 37 countries spanning 5 continents completed the survey. Most respondents were surgeons (n = 302, 89.6%) and working in an academic center (n = 286, 84.9%). The majority of centers (n = 166, 62.2%) performed less pancreatic surgery because of the COVID-19 pandemic, reducing the weekly pancreatic resection rate from 3 [interquartile range (IQR) 2-5] to 1 (IQR 0-2) (P < 0.001). Most centers screened for COVID-19 before pancreatic surgery (n = 233, 87.3%). Consensus was reached on 13 statements and 5 statements achieved moderate agreement. CONCLUSIONS: This global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion.

  838. Preoperative In-Hospital Rehabilitation Improves Physical Function in Patients with Pancreatic Cancer Scheduled for Surgery. Peer-reviewed

    Yukio Mikami, Ken Kouda, Shinji Kawasaki, Ken-Ichi Okada, Manabu Kawai, Yuji Kitahata, Motoki Miyazawa, Seiko Hirono, Michiaki Unno, Fumihiro Tajima, Hiroki Yamaue

    The Tohoku journal of experimental medicine　251　(4)　279-285　2020/08

    DOI： 10.1620/tjem.251.279 　

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    Low preoperative physical function in cancer patients is associated with postoperative complications; however, there have been no reports on the benefits of in-hospital preoperative rehabilitation on preoperative physical function in patients with pancreatic cancer. Therefore, the aim of this study was to quantitatively determine the effects of preoperative in-hospital rehabilitation provided under the supervision of a physiotherapist, on preoperative physical function in patients with pancreatic cancer. The study subjects were 26 patients (15 males, 11 females; age 71.2 ± 8.5 years, range: 51-87 years), including four patients with preoperative chemotherapy, scheduled for surgery for pancreatic cancer. Muscle strengthening exercises and aerobic exercises were conducted 11.9 ± 5.1 days prior to surgery. Cardiopulmonary exercise testing, 6-minute walk distance, and the Functional Independence Measure score were measured before and after the rehabilitation program. We also investigated the relation between the rehabilitation program and incidence of postoperative complications. All 26 study patients completed the preoperative rehabilitation program and no adverse events were noted. Peak oxygen uptake during cardiopulmonary exercise testing and 6-minute walk distance increased significantly after the rehabilitation program. The Functional Independence Measure score remained constant throughout the intervention. No wound infection, delirium, deep vein thrombosis, or respiratory complications were encountered postoperatively. In-hospital preoperative rehabilitation under the supervision of a physiotherapist significantly improved physical function and maintained physical activity in patients with pancreatic cancer. Such improvements may contribute toward preventing serious postoperative complications, resulting in better outcomes.

  839. Repertoire analysis of memory T-cell receptors in Japanese patients with inflammatory bowel disease. International-journal Peer-reviewed

    Yoichi Kakuta, Takeru Nakano, Takeo Naito, Kazuhiro Watanabe, Yasuhiro Izumiyama, Daisuke Okamoto, Ryo Ichikawa, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Takeshi Naitoh, Yoshitaka Kinouchi, Michiaki Unno, Atsushi Masamune

    JGH open : an open access journal of gastroenterology and hepatology　4　(4)　624-631　2020/08

    DOI： 10.1002/jgh3.12305 　

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    Background and Aim: The T-cell receptor (TCR) repertoire was assessed in response to various antigens and was considered to be associated with the pathogenesis of inflammatory bowel disease (IBD). Thus, we performed TCR repertoire analysis to examine the pathology of IBD from changes in the TCR repertoire of memory T cells in the intestinal lamina propria mononuclear cells (LPMCs) and peripheral blood mononuclear cells (PBMCs) of patients with IBD. Methods: LPMCs in the surgical specimens and PBMCs were isolated from 12 patients with IBD (5 patients with ulcerative colitis [UC] and 7 patients with Crohn's disease [CD]). PBMCs were collected from 10 healthy individuals as controls. Comprehensive TCR sequence analyses of adaptor-ligation polymerase chain reaction (PCR) products were performed using MiSeq. Results: The diversity of TCR-α and TCR-β in PBMCs was significantly lower in patients with IBD than that in controls (P = 0.00084 and 0.0013, respectively). Comparisons of TCR diversity in LPMCs and PBMCs between CD and UC showed that the diversity in LPMC was not affected by diseases, whereas that in PBMCs was significantly lower in CD than in UC (P = 0.045 and 0.049, respectively). Some TCR clones may have shown a specific increase or decrease in CD and UC, and many clones were common to both LPMCs and PBMCs in the same patients. Conclusion: The diversity of TCR clones in LPMCs and PBMCs in patients with IBD was significantly lower than that of PBMCs in controls. TCR diversity in PBMCs was particularly low in patients with CD.

  840. International expert consensus on laparoscopic pancreaticoduodenectomy. International-journal Peer-reviewed

    Renyi Qin, Michael L Kendrick, Christopher L Wolfgang, Barish H Edil, Chinnusamy Palanivelu, Rowan W Parks, Yinmo Yang, Jin He, Taiping Zhang, Yiping Mou, Xianjun Yu, Bing Peng, Palanisamy Senthilnathan, Ho-Seong Han, Jae Hoon Lee, Michiaki Unno, Steven W M Olde Damink, Virinder Kumar Bansal, Pierce Chow, Tan To Cheung, Nim Choi, Yu-Wen Tien, Chengfeng Wang, Manson Fok, Xiujun Cai, Shengquan Zou, Shuyou Peng, Yupei Zhao

    Hepatobiliary surgery and nutrition　9　(4)　464-483　2020/08

    DOI： 10.21037/hbsn-20-446 　

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    Importance: While laparoscopic pancreaticoduodenectomy (LPD) is being adopted with increasing enthusiasm worldwide, it is still challenging for both technical and anatomical reasons. Currently, there is no consensus on the technical standards for LPD. Objective: The aim of this consensus statement is to guide the continued safe progression and adoption of LPD. Evidence Review: An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open pancreaticoduodenectomy. Statements were produced upon reviewing the literature and assessed by the members of the expert panel. The literature search and its critical appraisal were limited to articles published in English during the period from 1994 to 2019. The Web of Science, Medline, and Cochrane Library and Clinical Trials databases were searched, The search strategy included, but was not limited to, the terms 'laparoscopic', 'pancreaticoduodenectomy, 'pancreatoduodenectomy', 'Whipple's operation', and 'minimally invasive surgery'. Reference lists from the included articles were manually checked for any additional studies, which were included when appropriate. Delphi method was used to establish expert consensus and the AGREE II-GRS Instrument was applied to assess the methodological quality and externally validate the final statements. The statements were further discussed during a one-day face-to-face meeting at the 1st Summit on Minimally Invasive Pancreatico-Biliary Surgery in Wuhan, China. Findings: Twenty-eight international experts from 8 countries constructed the expert panel. Sixteen statements were produced by the members of the expert panel. At least 80% of responders agreed with the majority (80%) of statements. Other than three randomized controlled trials published to date, most evidences were based on level 3 or 4 studies according to the AGREE II-GRS Instrument. Conclusions and Relevance: The Wuhan international expert consensus meeting on LPD has produced a set of clinical practice statements for the safe development and progression of LPD. LPD is currently in its development and exploration stages, as defined by the international IDEAL framework for surgical innovation. More robust randomized controlled trial and registry study are essential to proceed with the assessment of LPD.

  841. Tips for operation of inguinal hernia after implantation of artificial urinary sphincter following radical prostatectomy: report of two cases. International-journal Peer-reviewed

    Ryusuke Saito, Naoki Tanaka, Takashi Aizawa, Hirofumi Imoto, Akihiro Yamamura, Takeshi Aoki, Naoki Kawamorita, Hiroaki Musha, Shinobu Ohnuma, Fuyuhiko Motoi, Akihiro Ito, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Journal of surgical case reports　2020　(8)　rjaa150　2020/08

    DOI： 10.1093/jscr/rjaa150 　

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    Urinary incontinence is one of the common complications after radical prostatectomy along with inguinal hernia. Artificial urethral sphincter implantation is widely accepted as a treatment option. We report two surgical cases of inguinal hernia after artificial urethral sphincter implantation for urinary incontinence following radical prostatectomy. In Case 1, since the device went through the inguinal canal, adhesion around the pubis was extremely hard. In Case 2, the device was placed on the ventral side of the rectus abdominis muscle, so it was operable almost as normal. In each case, the surgical procedure was considered carefully after confirming the location of the device by preoperative computed tomography and ultrasonography. Hernia repair was successfully performed using the Lichtenstein method. There are few reports regarding surgical repair of inguinal hernia following artificial urinary sphincter implantation. Preoperative image and appropriate choice of approach could facilitate safe and secure surgery.

  842. Resistin-like molecule beta, a colonic epithelial protein, exhibits antimicrobial activity against Staphylococcus aureus including methicillin-resistant strains. Peer-reviewed

    Kazuhiro Watanabe, Kikuji Itoh, Sang-Hee Park, Mitsuo Kaku, Keiko Ishii, Hironobu Sasano, Takeshi Naitoh, Michiaki Unno, Kouhei Fukushima

    Surgery today　50　(8)　920-930　2020/08

    DOI： 10.1007/s00595-020-01974-z 　

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    PURPOSE: Resistin-like molecule beta (RELMβ) is a small cysteine-rich protein secreted by colonic epithelial cells. RELMβ mRNA and protein expressions are dramatically induced by bacterial exposure in germ-free mice. We hypothesized that RELMβ has antimicrobial activity. METHODS: The antimicrobial activity of RELMβ was screened by an agar spot test and confirmed by a liquid broth test. The amount of RELMβ in human stools was semi-quantified by Western blot analysis. The induction of RELMβ mRNA and protein expression by bacteria was measured by quantitative RT-PCR using LS174T cells. Electron microscopic immunohistochemistry was performed using polyclonal anti-RELMβ antibody. RESULTS: RELMβ showed antimicrobial activity against S. aureus and all MRSAs examined in a dose- and pH-dependent fashion. Western blot study showed that the amount of RELMβ in healthy human stools was comparable to that exhibiting antimicrobial activity in vitro. Both RELMβ mRNA and protein expression were induced by heat-inactivated S. aureus, but not by E. coli in LS174T cells. Electron microscopic immunohistochemistry showed that RELMβ bound to the cell surface of S. aureus, followed by destruction of the bacterial cytoplasm. CONCLUSIONS: RELMβ is a colonic antimicrobial protein and its antibacterial activity is species selective. Because RELMβ is abundant in healthy human stool, RELMβ may modulate gut flora.

  843. Serum procalcitonin as an early diagnostic marker of severe postoperative complications after elective pancreaticoduodenectomy. Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Hiroki Hayashi, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　2020/07/22

    DOI： 10.1002/jhbp.809 　

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    BACKGROUND/PURPOSE: To evaluate the clinical utility of serum procalcitonin (PCT) as a diagnostic marker for the severe postoperative complications associated with pancreaticoduodenectomy (PD). METHODS: A total of 387 patients were enrolled and the PCT and C-reactive protein (CRP) values were compared between the non-severe complications group (Clavien-Dindo classification Grade IIIb and lower) and severe complications (Grade IVa and higher). RESULTS: Severe complications occurred in 16 patients. In the severe complications group, CRP levels peaked on postoperative day (POD) 3, whereas PCT levels peaked on POD 1. The PCT levels on PODs 1-5 were significantly higher in the severe complications group. Regarding the diagnostic performance, the PCT value on POD 2 higher than 2.1 ng/mL revealed the highest performance, with 66.7% sensitivity and 78.6% specificity. Based on the postoperative kinetics and multivariate analysis, PCT and CRP both act independently of each other and the combination assay improved the diagnostic power (area under the curve 0.781; sensitivity 60.0%; specificity 85.6%). Preoperative biliary drainage was found to affect the perioperative PCT values and subgroup analysis stratified by the drainage procedure improved diagnostic sensitivity (~85%). CONCLUSIONS: Procalcitonin in the early postoperative period can serve as an earlier detector for the development of severe complications after PD.

  844. p-NEN診療ガイドラインの問題点 腫瘍径が小さい膵神経内分泌腫瘍に対する診断能の検討

    滝川 哲也, 池田 美緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A154-A154　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  845. 切除不能膵癌に対する集学的治療 遠隔転移を有する切除不能膵癌に対する外科的切除の意義

    水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 正宗 淳, 海野 倫明

    膵臓　35　(3)　A182-A182　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  846. 急性膵炎に対する局所合併症治療 内視鏡的ネクロセクトミー後のWONの再発要因について

    粂 潔, 菅野 敦, 池田 未緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A208-A208　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  847. 高齢者の膵管内乳頭粘液性腺癌術後5年目に生じた残膵病変に対し残膵全摘を施行した1例

    千葉 和治, 畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 高舘 達之, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 菅野 敦, 正宗 淳, 大森 優子, 古川 徹, 亀井 尚, 海野 倫明

    膵臓　35　(3)　A402-A402　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  848. 新規薬剤導入時代の手術を要する潰瘍性大腸炎症例の変化

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A225-A225　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  849. クローン病の直腸肛門管癌症例の特徴についての検討(続報)

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 梶原 大輝, 唐澤 秀明, 山村 明寛, 井本 博文, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A226-A226　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  850. 膵全摘術の現状と展望 高齢者に対する膵全摘の問題と対策

    伊関 雅裕, 水間 正道, 青木 修一, 畠 達夫, 三浦 孝之, 前田 晋平, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 海野 倫明

    膵臓　35　(3)　A114-A114　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  851. 後期高齢者における膵癌外科治療の短期および長期成績

    森川 孝則, 元井 冬彦, 水間 正道, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 大塚 英郎, 大沼 忍, 武者 宏昭, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A339-A339　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  852. 肝門部領域胆管癌の術前診断と治療戦略

    中川 圭, 益田 邦洋, 青木 修一, 伊関 雅裕, 高舘 達之, 大塚 英郎, 畠 達夫, 三浦 孝之, 前田 晋平, 有明 恭平, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A391-A391　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  853. 糖尿病関連症状を契機に発見された膵癌患者の臨床学的特徴と予後

    滝川 哲也, 池田 美緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A270-A270　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  854. Effects of Short-Term Normothermic and Subnormothermic Perfusion After Cold Preservation on Liver Transplantation From Donors After Cardiac Death

    Shuhei Yamada, Shigehito Miyagi, Yasuyuki Hara, Yuta Kakizaki, Hideaki Sasajima, Kazuhiro Mitsui, Keisei Fujimori, Michiaki Unno, Takashi Kamei, Masafumi Goto

    Transplantation Proceedings　52　(6)　1639-1642　2020/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.transproceed.2020.01.147 　

    ISSN： 0041-1345

  855. Cytoprotective Effects of Mesenchymal Stem Cells During Liver Transplantation From Donors After Cardiac Death in Swine

    Hideaki Sasajima, Shigehito Miyagi, Shuhei Yamada, Yuta Kakizaki, Takashi Kamei, Michiaki Unno, Masafumi Goto

    Transplantation Proceedings　52　(6)　1891-1900　2020/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.transproceed.2020.01.165 　

    ISSN： 0041-1345

  856. pT1直腸癌の内視鏡治療および外科的切除後の治療成績

    鈴木 ゆき恵, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　73　(7)　335-335　2020/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  857. 術前化学放射線療法施行後に手術を施行した局所進行下部直腸癌の術後短期成績

    伊勢 一郎, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　73　(7)　358-358　2020/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  858. 膵全摘術の現状と展望 National clinical databaseによる膵全摘術の術後重症合併症リスクモデル

    橋本 大輔, 水間 正道, 隈丸 拓, 宮田 裕章, 近本 亮, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 濱田 晋, 水元 一博, 山上 裕機, 山本 雅一, 掛地 吉弘, 瀬戸 泰之, 馬場 秀夫, 海野 倫明, 下瀬川 徹, 岡崎 和一

    膵臓　35　(3)　A119-A119　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  859. 膵癌のconversion surgery:課題と展望 局所進行切除不能膵癌に対するconversion Surgery後の早期再発例から切除適応を考える

    林 洋毅, 水間 正道, 畠 達夫, 青木 修一, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 中川 圭, 森川 孝則, 元井 冬彦, 海野 倫明

    膵臓　35　(3)　A243-A243　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  860. 切除可能膵癌に対する術前治療 切除可能膵癌に対する術前化学療法の治療成績

    元井 冬彦, 青木 修一, 畠 達夫, 三浦 孝之, 高館 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 海野 倫明

    膵臓　35　(3)　A144-A144　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  861. 膵頭十二指腸切除後の重症合併症の予測診断における血清プロカルシトニン測定の有用性

    畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 三浦 孝之, 高舘 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 海野 倫明

    膵臓　35　(3)　A286-A286　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  862. 洗浄細胞診陽性膵癌に対する化学療法先行治療の有用性

    有明 恭平, 水間 正道, 林 洋毅, 畠 達夫, 青木 修一, 高舘 達之, 三浦 孝之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 海野 倫明

    膵臓　35　(3)　A302-A302　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  863. 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

    亀井 敬子, 松本 逸平, 加藤 宏之, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A115-A115　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  864. 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

    加藤 宏之, 亀井 敬子, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A117-A117　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  865. 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

    須藤 広誠, 亀井 敬子, 加藤 宏之, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A118-A118　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  866. 日本人炎症性腸疾患患者のメモリーT細胞受容体レパトア解析

    中野 健, 角田 洋一, 内藤 健夫, 渡辺 和宏, 泉山 泰宏, 岡本 大祐, 市川 遼, 諸井 林太郎, 黒羽 正剛, 金澤 義丈, 木村 智哉, 志賀 久嗣, 内藤 剛, 木内 善孝, 海野 倫明, 正宗 敦

    日本消化器病学会雑誌　117　(臨増総会)　A221-A221　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  867. 若年で発症した膵癌症例の臨床像 日本膵臓学会膵癌登録データによる解析

    江口 英利, 山上 裕機, 海野 倫明, 水間 正道, 濱田 晋, 五十嵐 久人, 黒木 保, 里井 壯平, 清水 泰博, 谷 眞至, 丹野 誠志, 廣岡 芳樹, 藤井 努, 正宗 淳, 水元 一博, 糸井 隆夫, 江川 新一, 児玉 裕三, 田中 雅夫, 下瀬川 徹, 岡崎 和一

    膵臓　35　(3)　A100-A100　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  868. pT1直腸癌の内視鏡治療および外科的切除後の治療成績

    鈴木 ゆき恵, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　73　(7)　335-335　2020/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  869. 術前化学放射線療法施行後に手術を施行した局所進行下部直腸癌の術後短期成績

    伊勢 一郎, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　73　(7)　358-358　2020/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  870. 新規薬剤導入時代の手術を要する潰瘍性大腸炎症例の変化

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A225-A225　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  871. クローン病の直腸肛門管癌症例の特徴についての検討(続報)

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 梶原 大輝, 唐澤 秀明, 山村 明寛, 井本 博文, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　117　(臨増総会)　A226-A226　2020/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  872. Risks of Living Donor Liver Transplantation Using Small-For-Size Grafts

    Shigehito Miyagi, Yoshihiro Shono, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Kengo Sasaki, Yuki Miyazaki, Yuta Kakizaki, Hideaki Sasajima, Takashi Kamei, Michiaki Unno

    Transplantation Proceedings　52　(6)　1825-1828　2020/07

    Publisher: Elsevier BV

    DOI： 10.1016/j.transproceed.2020.01.136 　

    ISSN： 0041-1345

  873. 【胆膵疾患における栄養サポート】慢性膵炎術後の栄養サポート Peer-reviewed

    石田 晶玄, 海野 倫明

    胆と膵　41　(7)　695-698　2020/07

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  874. Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms. International-journal Peer-reviewed

    Tomoyoshi Tachibana, Atsuko Kasajima, Takeshi Aoki, Tomoaki Tabata, Keely McNamara, Samaneh Yazdani, Sato Satoko, Fumiyoshi Fujishima, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    The Journal of steroid biochemistry and molecular biology　201　105694-105694　2020/07

    DOI： 10.1016/j.jsbmb.2020.105694 　

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    Progesterone receptor (PgR) inhibits cell proliferation in pancreatic neuroendocrine neoplasms (PanNEN). In non-neoplastic pancreas, loss of PgR induces β-cell proliferation and insulin production. However, detailed association between PgR and insulin producing PanNENs is poorly understood. Insulin, proinsulin, and PgR were immunolocalized in 82 PanNENs (54 non-functioning PanNENs: NF-PanNENs and 28 insulinomas). The status of immunoreactivity was compared to the clinicopathological factors of the patients. Immunoreactivity was also confirmed by employing the double-immunohistochemistry. These results were also compared with those in non-neoplastic Langerhans islets. PgR immunoreactivity was significantly higher in insulinomas than that in NF-PanNENs (p < 0.001). Insulin and proinsulin immunoreactivity was also detected in 20 (37 %) of (single cell) insulin positive NFs (Inspos-NF-PanNEN), in which PgR expression was higher than in insulin negative NF-PanNENs (Insneg-NF-PanNEN, p = 0.03). The ratio of PgR-insulin double positive cells to overall insulin positive cells, as well as PgR-proinsulin double positive cells to proinsulin positive cells, was detected to the same degree in insulinoma (PgR-insulin 70 %, PgR-proinsulin 66 %), Inspos-NF-PanNENs (PgR-insulin 65 %, PgR-proinsulin 68 %) and normal islet (PgR-insulin 80 %, PgR-proinsulin 72 %). PgR and insulin expressing cells colocalize in tumor cells of the PanNENs regardless of the hormone-related symptoms of the patients. Inhibitory effect of PgR on tumor cells might be associated with the favourable clinical outcome of insulinoma patients.

  875. Propensity score-matched analysis of internal stent vs external stent for pancreatojejunostomy during pancreaticoduodenectomy: Japanese-Korean cooperative project. International-journal Peer-reviewed

    Manabu Kawai, Hiroki Yamaue, Jin-Young Jang, Katsuhiko Uesaka, Michiaki Unno, Masafumi Nakamura, Tsutomu Fujii, Sohei Satoi, Seong Ho Choi, Masayuki Sho, Takumi Fukumoto, Song Cheol Kim, Tae Ho Hong, Wataru Izumo, Dong Sup Yoon, Ryosuke Amano, Sang-Jae Park, Sae Byeol Choi, Hee Chul Yu, Joo Seop Kim, Young Joon Ahn, Hongbeom Kim, Ryo Ashida, Seiko Hirono, Jin Seok Heo, Ki Byung Song, Joon Seong Park, Masakazu Yamamoto, Toshio Shimokawa, Sun-Whe Kim

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　20　(5)　984-991　2020/07

    DOI： 10.1016/j.pan.2020.06.014 　

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    BACKGROUND: Several studies comparing internal and external stents have been conducted with the aim of reducing pancreatic fistula after PD. There is still no consensus, however, on the appropriate use of pancreatic stents for prevention of pancreatic fistula. This multicenter large cohort study aims to evaluate whether internal or external pancreatic stents are more effective in reduction of clinically relevant pancreatic fistula after pancreaticoduodenectomy (PD). METHODS: We reviewed 3149 patients (internal stent n = 1,311, external stent n = 1838) who underwent PD at 20 institutions in Japan and Korea between 2007 and 2013. Propensity score matched analysis was used to minimize bias from nonrandomized treatment assignment. The primary endpoint was the incidence of clinically relevant pancreatic fistula. This study was registered on the UMIN Clinical Trials Registry (UMIN000032402). RESULTS: After propensity score matched analysis, clinically relevant pancreatic fistula occurred in more patients in the external stents group (280 patients, 28.7%) than in patients in the internal stents group (126 patients, 12.9%) (OR 2.713 [95% CI, 2.139-3.455]; P < 0.001). In subset analysis of a high-risk group with soft pancreas and no dilatation of the pancreatic duct, clinically relevant pancreatic fistula occurred in 90 patients (18.8%) in internal stents group and 183 patients (35.4%) in external stents group. External stents were significantly associated with increased risk for clinically relevant pancreatic fistula (OR 2.366 [95% CI, 1.753-3.209]; P < 0.001). CONCLUSION: Propensity score matched analysis showed that, regarding clinically relevant pancreatic fistula after PD, internal stents are safer than external stents for pancreaticojejunostomy.

  876. Mechanism of Bile Acid Reabsorption in the Biliopancreatic Limb After Duodenal-Jejunal Bypass in Rats. International-journal Peer-reviewed

    Tomotaka Ueno, Naoki Tanaka, Hirofumi Imoto, Masamitsu Maekawa, Atsushi Kohyama, Kazuhiro Watanabe, Fuyuhiko Motoi, Takashi Kamei, Michiaki Unno, Takeshi Naitoh

    Obesity surgery　30　(7)　2528-2537　2020/07

    DOI： 10.1007/s11695-020-04506-3 　

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    BACKGROUND: Bile acids (BAs) are important in the metabolic effects of bariatric surgery. Most BAs are reabsorbed in the ileum and recycled back to the liver. We have reported that this enterohepatic circulation was shortened by duodenal-jejunal bypass (DJB), and the biliopancreatic (BP)-limb plays an important role in reabsorption of BAs. However, the mechanism of BA reabsorption in BP-limb remains uncertain. We aimed to investigate the mechanisms of BA reabsorption after DJB, especially focusing on carrier-mediated transport of BAs and the impact of the presence or absence of lipids on BA reabsorption. METHODS: Otsuka-Long-Evans-Tokushima fatty rats or Sprague-Dawley rats were assigned to a control group and DJB group. BA levels in the divided small intestine were quantified with liquid chromatography-mass spectrometry. Labeled BA was injected and perfused with BA transporter inhibitors or mixture of lipids in the isolated BP-limb, and bile was sampled and analyzed. RESULTS: Conjugated BA levels in the BP-limb were significantly higher than that of the control group. BA absorption tended to decrease by the apical sodium-dependent BA transporter inhibitor and was significantly decreased by the organic anion-transporting peptide (OATP) inhibitor. BA absorption tended to increase in the absence of lipid solutions compared with that in the presence of lipid solutions. CONCLUSION: We attributed the increased BA reabsorption in the BP-limb to lack of food in the BP-limb, which contains concentrated BAs and no lipids. OATP played an important role in BA reabsorption in the BP-limb. Therefore, BAs would be reabsorbed in different manners after DJB.

  877. Serum Anti-p53 Antibody Can Serve as a Predictive Marker for Histological Grade of Intraductal Papillary Mucinous Neoplasms of the Pancreas. International-journal Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masahiro Iseki, Yuko Omori, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Takeshi Naitoh, Toru Furukawa, Michiaki Unno

    Pancreas　49　(6)　768-773　2020/07

    DOI： 10.1097/MPA.0000000000001570 　

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    OBJECTIVE: The aim of the study was to clarify the diagnostic impact of measuring serum anti-p53 antibody (S-p53Ab) in predicting the histological grades of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. METHODS: We compared the measured values and positive prevalence of S-p53Ab across the different histological grades of 111 resected IPMN cases. We also evaluated the TP53 alterations using immunohistochemistry and next-generation sequencing. RESULTS: Serum anti-p53 antibody were detected in 6 of 111 cases, all of their histological grades were high-grade dysplasia (HGD) and invasive carcinoma (INV). Positive prevalence of S-p53Ab was higher in cases with INV (4/35 cases, 11.4%) than those with HGD (2/38 cases, 5.3%), whereas S-p53Abs were undetectable in cases with low-grade dysplasia. Measured S-p53Ab values were not correlated with either carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA 19-9). In 4 of 6 S-p53Ab-positive cases, the TP53 alterations-somatic pathogenic mutations or aberrant immunoreactivity-were identified in their IPMN lesions. A combination assay of S-p53Ab, CEA, and CA 19-9 revealed a 38.4% sensitivity and 81.6% specificity for predicting HGD/INV. CONCLUSIONS: Serum anti-p53 antibody can serve as a surrogate marker for TP53 alterations and help predict the presence of HGD/INV in cases with IPMN, in combination with CEA and CA 19-9.

  878. How does intestinal-type intraductal papillary mucinous neoplasm emerge? CDX2 plays a critical role in the process of intestinal differentiation and progression. International-journal Peer-reviewed

    Yuko Omori, Yusuke Ono, Toshikazu Kobayashi, Fuyuhiko Motoi, Hidenori Karasaki, Yusuke Mizukami, Naohiko Makino, Yoshiyuki Ueno, Michiaki Unno, Toru Furukawa

    Virchows Archiv : an international journal of pathology　477　(1)　21-31　2020/07

    DOI： 10.1007/s00428-020-02806-8 　

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    Intestinal-type intraductal papillary mucinous neoplasm (IPMN) of the pancreas is clinicopathologically distinctive. Our research aimed to elucidate the molecular mechanism of the development and progression of the intestinal-type IPMN. In 60 intestinal-type IPMN specimens, histological transitions from gastric-type epithelia to intestinal-type epithelia were observed in 48 cases (80%). CDX2/MUC2/alcian blue triple staining indicated that CDX2 appeared to precede MUC2 expression and subsequent alcian blue-positive mucin production. Expression of p21 and Ki-67 seemed to be accelerated by CDX2 expression (p = 6.02e-13 and p = 3.1e-09, respectively). p21/Ki-67 double staining revealed that p21 was mostly expressed in differentiated cells in the apex of papillae, while Ki-67 was expressed in proliferative cells in the base of papillae. This clear cellular arrangement seemed to break down with the progression of atypical grade and development of invasion (p = 0.00197). Intestinal-type IPMNs harbored frequent GNAS mutations (100%, 25/25) and RNF43 mutations (57%, 8/14) and shared identical GNAS and KRAS mutations with concurrent gastric-type IPMNs or incipient gastric-type neoplasia (100%, 25/25). RNF43 mutations showed emerging or being selected in intestinal-type neoplasms along with ß-catenin aberration. Activation of protein kinase A and extracellular-regulated kinase was observed in CDX2-positive intestinal-type neoplasm. These results suggest that gastric-type epithelia that acquire GNAS mutations together with induction of intrinsic CDX2 expression may evolve with clonal selection and additional molecular aberrations including RNF43 and ß-catenin into intestinal-type IPMNs, which may further progress with complex villous growth due to disoriented cell cycle regulation, acceleration of atypical grade, and advance to show an invasive phenotype.

  879. Epidemiological features of immunoglobulin G4-related sclerosing cholangitis in Japan. Peer-reviewed

    Atsushi Tanaka, Mitsuru Mori, Kensuke Kubota, Itaru Naitoh, Takahiro Nakazawa, Hajime Takikawa, Michiaki Unno, Terumi Kamisawa, Shigeyuki Kawa, Kazuichi Okazaki

    Journal of hepato-biliary-pancreatic sciences　27　(9)　598-603　2020/06/30

    DOI： 10.1002/jhbp.793 　

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    BACKGROUND/PURPOSE: Epidemiological data on immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) are scarce. METHOD: We randomly selected healthcare facilities from a list of all facilities in Japan. The selection rate was determined according to a stratification based on the facility characteristics and scale. We sent questionnaires to the selected facilities enquiring about the number and sex of patients with IgG4-SC in 2018. Among responding facilities, we further inquired about the clinical characteristics of the patients with IgG4-SC. RESULTS: We selected 1,180 departments from health centers across Japan. Of them, 532 (45.1%) responded to the questionnaires. The number of reported patients with IgG4-SC was 1,045, and the estimated point prevalence was 2.18 (95% confidence interval, 2.13-2.23) per 100,000 population. In addition, we enrolled 1,096 patients with IgG4-SC, combining data from previously and newly registered patients. Male patients comprised 79.5% of the population and patients aged 60-80 years had the highest risk for developing the disease. The follow-up period was 5.1±4.0 years and the 5- and 10-year overall survival rates were 95.3% and 89.0%, respectively. CONCLUSIONS: The point prevalence of IgG4-SC was 2.18 per 100,000 population. The epidemiological features were similar to those observed in previous studies.

  880. An Integrated Genomic and Transcriptomic Analysis Reveals Candidates of Susceptibility Genes for Crohn's Disease in Japanese Populations. International-journal Peer-reviewed

    Yoichi Kakuta, Ryo Ichikawa, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Takehiro Torisu, Kazuhiro Watanabe, Akihiro Asakura, Takeru Nakano, Yasuhiro Izumiyama, Daisuke Okamoto, Takeo Naito, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Takeshi Naito, Motohiro Esaki, Yosuke Kawai, Katsushi Tokunaga, Minoru Nakamura, Takayuki Matsumoto, Masao Nagasaki, Yoshitaka Kinouchi, Michiaki Unno, Atsushi Masamune

    Scientific reports　10　(1)　10236-10236　2020/06/24

    DOI： 10.1038/s41598-020-66951-5 　

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    Expression quantitative trait locus (eQTL) analyses have enabled us to predict the function of disease susceptibility SNPs. However, eQTL for the effector memory T cells (TEM) located in the lamina propria mononuclear cells (LPMCs), which play an important role in Crohn's disease (CD), are not yet available. Thus, we conducted RNA sequencing and eQTL analyses of TEM cells located in the LPMCs from IBD patients (n = 20). Genome-wide association study (GWAS) was performed using genotyping data of 713 Japanese CD patients and 2,063 controls. We compared the results of GWAS and eQTL of TEM, and also performed a transcriptome-wide association study using eQTL from Genotype Tissue Expression project. By eQTL analyses of TEM, correlations of possible candidates were confirmed in 22,632 pairs and 2,463 genes. Among these candidates, 19 SNPs which showed significant correlation with tenascin-XA (TNXA) expression were significantly associated with CD in GWAS. By TWAS, TNFSF15 (FDR = 1.35e-13) in whole blood, ERV3-1 (FDR = 2.18e-2) in lymphocytes, and ZNF713 (FDR = 3.04e-2) in the sigmoid colon was significantly associated with CD. By conducting integration analyses using GWAS and eQTL data, we confirmed multiple gene transcripts are involved in the development of CD.

  881. Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti-HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report. International-journal Peer-reviewed

    Kengo Fukuoka, Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Hirofumi Watanabe, Shinji Taniuchi, Takeshi Naitoh, Takanori Ishida, Michiaki Unno, Takashi Kamei

    Transplantation proceedings　52　(6)　1937-1939　2020/06/23

    DOI： 10.1016/j.transproceed.2020.02.130 　

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    Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.

  882. Risk factors and characteristics of young patients with the biliary tract carcinoma: results of a project study for biliary surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Peer-reviewed

    Kyohei Ariake, Michiaki Unno, Hiroshi Yoshida, Shoji Kubo, Akihiko Horiguchi, Hiroki Yamaue, Masakazu Yamamoto

    Journal of hepato-biliary-pancreatic sciences　27　(9)　571-580　2020/06/08

    DOI： 10.1002/jhbp.776 　

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    PURPOSE: This study aimed to elucidate the characteristics of biliary tract carcinoma (BTC) in young patients. METHODS: This is a nationwide multicenter, retrospective cohort study supervised by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS). Clinicopathological data of patients aged <50 years diagnosed with BTC from January 1997 to December 2011 were collected from 211 training institutes for highly advanced surgery registered by the JHBPS. RESULTS: Data of 774 young patients aged <50 years were obtained from 102 institutes. Pancreaticobiliary maljunction (PBM) (10.6%) was most frequently associated with young BTC. However, organic solvents caused by printing or other occupations were only 2.5%. PBM was further associated with early onset of BTC and was noted in 38.9% of patients aged <30 years. Subgroup analysis revealed that the distributions of PBM, choledochal cysts, cholelithiasis, hepatitis B virus, and past history of cancer were significantly varied depending on the site of BTC. These results suggested that each site of BTC has a different mechanism for cancer development. CONCLUSION: Although the most frequent factor for young BTC patients was PBM, cancer-associated factors were dramatically different in each BTC site. These results might be useful to elucidate the etiology of young BTC patients.

  883. Clinicopathological characteristics of intraductal papillary neoplasm of the bile duct: a Japan-Korea collaborative study. Peer-reviewed

    Keiichi Kubota, Jin-Young Jang, Yasuni Nakanuma, Kee-Taek Jang, Yasuo Haruyama, Noriyoshi Fukushima, Toru Furukawa, Seung-Mo Hong, Yuhki Sakuraoka, Haeryoung Kim, Takatsugu Matsumoto, Kyung Bun Lee, Yoh Zen, Jaeri Kim, Masaru Miyazaki, Dong Wook Choi, Jin Seok Heo, Itaru Endo, Shin Hwang, Masafumi Nakamura, Ho-Seong Han, Shinji Uemoto, Sang Jae Park, Eun Kyung Hong, Atsushi Nanashima, Dong-Sik Kim, Joo Young Kim, Tetsuo Ohta, Koo Jeong Kang, Takumi Fukumoto, Yang Won Nah, Hyung Il Seo, Kazuo Inui, Dong-Sup Yoon, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　27　(9)　581-597　2020/06/08

    DOI： 10.1002/jhbp.785 　

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    BACKGROUND: The prevalent location and incidence of intraductal papillary neoplasm of the bile duct (IPNB) and invasive carcinoma associated with them have varied markedly among studies due to differences in diagnostic criteria and tumor location. METHODS: IPNBs were classified into two types: Type 1 IPNB, being histologically similar to intraductal papillary mucinous neoplasm of the pancreas, and Type 2 IPNB, having a more complex histological architecture with irregular papillary branching or foci of solid-tubular components. Medical data were evaluated. RESULTS: Among 694 IPNB patients, 520 and 174 had Type 1 and Type 2, respectively. The levels of AST, ALT, ALP, T. Bil, and CEA were significantly higher in patients with Type 2 than in those with Type 1. Type 1 IPNB was more frequently located in the intrahepatic bile duct than Type 2, whereas Type 2 was more frequently located in the distal bile duct than Type 1 IPNB (P < 0.001). There were significant differences in 5-year cumulative survival rates (75.2% vs 50.9%; P < 0.0001) and 5-year cumulative disease-free survival rates (64.1% vs 35.3%; P < 0.0001) between the two groups. CONCLUSION: Type 1 and Type 2 IPNBs differ in their clinicopathological features and prognosis. This classification may help to further understand IPNB.

  884. Methylation-mediated silencing of the LIM homeobox 6 (LHX6) gene promotes cell proliferation in human pancreatic cancer. International-journal Peer-reviewed

    Yakefujiang Abudurexiti, Zhaodi Gu, Kanchan Chakma, Tatsuo Hata, Fuyuhiko Motoi, Michiaki Unno, Akira Horii, Shinichi Fukushige

    Biochemical and biophysical research communications　526　(3)　626-632　2020/06/04

    DOI： 10.1016/j.bbrc.2020.03.120 　

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    Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. DNA methylation-mediated silenced genes in pancreatic cancer were searched for using the methyl-CpG targeted transcriptional activation (MeTA) method, and LHX6 (LIM homeobox 6), a transcription factor involved in embryogenesis and head development, was selected as a strong candidate gene. LHX6 was downregulated in most of the pancreatic cancer cell lines (83%, 10/12), mainly through promoter hypermethylation and histone deacetylation. Furthermore, LHX6 was methylated in primary pancreatic cancer specimens (57%, 16/28) in a tumor-specific manner. Re-expression of LHX6 inhibited colony formation and proliferation in LHX6 low-expressing pancreatic cancer cell lines, PK-1 and PK-9. In contrast, knockdown of LHX6 accelerated cell proliferation in LHX6 high-expressing pancreatic cancer cell lines, PCI-35 and MIA PaCa-2. In order to analyze LHX6 downstream genes, we performed microarray analyses using LHX6 inducible PK-1 and PK-9 and found that LHX6 induction upregulated several genes that had tumor suppressive functions. Among these, we focused on TFPI2 (Tissue factor pathway inhibitor-2) and found that TFPI2 was greatly downregulated in all twelve pancreatic cancer cell lines. Our present results suggest that epigenetic inactivation of LHX6 plays an important role in pancreatic tumorigenesis by promoting cell proliferation through aberrant transcriptional regulation of several cancer-related genes.

  885. 【膵癌診療ガイドライン改訂を外科医はこう読み解く-ディベート&ディスカッション】ディスカッション 切除可能膵癌に対する術前化学療法の手術先行に対する優越性 Peer-reviewed

    元井 冬彦, 海野 倫明

    臨床外科　75　(6)　650-657　2020/06

    Publisher: (株)医学書院

    ISSN： 0386-9857

    eISSN： 1882-1278

  886. Comparison of pancreaticoduodenectomy and bile duct resection for middle bile duct cancer: A multi-center collaborating study of Japan and Korea. Peer-reviewed

    Hiroki Hayashi, Jin-Young Jang, Kyung Sik Kim, Jin Sub Choi, Takeshi Takahara, Sung Hoon Choi, Satoshi Hirano, Hee Chul Yu, Syuichiro Uemura, Michiaki Unno

    Journal of hepato-biliary-pancreatic sciences　27　(6)　289-298　2020/06

    DOI： 10.1002/jhbp.724 　

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    BACKGROUND: It is currently unknown whether bile duct segmental resection (BDSR) is an acceptable method for localized middle bile duct cancer (mid-BDC) when R0 resection can be achieved. This study aimed to investigate the short- and long-term outcomes of mid-BDC patients treated with pancreaticoduodenectomy (PD) compared to those for BDSR. METHODS: This was a retrospective, Japanese and Korean multi-center collaboration study based on patients' medical records. RESULTS: A total of 663 patients, including 245 BDSR and 418 PD cases, were enrolled. The incidence of postoperative pancreatic fistula (3.3% vs 44.1%, P < .0001), surgical site infection in the organ space (6.1% vs 17.7%, P < .0001) and clinically problematic morbidities (15.9% vs 32.8%, P < .0001) was significantly higher in the PD group. There was no difference in the mortality rate (0.8% vs 1.7%, P = .3566). Local (33.9% vs 14.4%, P < .0001) and lymph node (22.4% vs 11.0%, P < .0001) recurrence rates were significantly higher in the BDSR group. Relapse-free survival (25.0 vs 34.0 months, P = .0184) and overall survival (41.2 vs 60.1 months, P = .0019) were significantly longer in the PD group. The PD group had significantly better prognosis in stage IA/IB cases (58.3 vs 111.5 months, P = .0067), which were the best indicators for BDSR, even when R0 resection was achieved. In multivariate analysis, BDSR was an independent poor prognostic factor. CONCLUSION: Despite the inferior perioperative short-term outcomes, our data advocate that PD should be the standard procedure for mid-BDCs and that BDSR should be avoided even if R0 resection can be achieved. (UMIN000017914).

  887. Effects of a new perioperative enhanced recovery after surgery protocol in hepatectomy for hepatocellular carcinoma. Peer-reviewed

    Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Kazuhiro Mitsui, Michiaki Unno, Takashi Kamei

    Surgery today　50　(6)　615-622　2020/06

    DOI： 10.1007/s00595-019-01930-6 　

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    PURPOSE: Enhanced recovery after surgery (ERAS) protocols are becoming the standard of care in many surgical procedures, although data on their use following hepatectomy for hepatocellular carcinoma (HCC) are scarce. This study aimed to evaluate the effects of a new ERAS pathway in terms of the patient nutrition status after hepatectomy for HCC. METHODS: This is a retrospective analysis of 97 consecutive patients treated with open or laparoscopic hepatectomy for HCC between January 2011 and August 2014. We compared the perioperative outcomes between patients whose treatment incorporated the ERAS pathway and control patients. The nutritional status was evaluated using the controlling nutritional status score. RESULTS: The length of hospital stay (LOS) after both open and laparoscopic hepatectomy was shorter for the ERAS group than the control group. The days of ambulation and cessation of intravenous infusion were earlier and the postoperative nutrition status was statistically better in the ERAS group than in the control group. A multivariate analysis showed that being in the non-ERAS group was a risk factor of delayed discharge. There were no marked differences in the rate of severe complications between the two groups. CONCLUSIONS: The ERAS pathway seems feasible and safe and results in a faster recovery, reduced LOS, improved nutrition status, and fewer severe complications.

  888. Adjuvant and neoadjuvant treatment for pancreatic adenocarcinoma. International-journal Peer-reviewed

    Fuyuhiko Motoi, Michiaki Unno

    Japanese journal of clinical oncology　50　(5)　483-489　2020/05/05

    DOI： 10.1093/jjco/hyaa018 　

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    The prognosis of pancreatic adenocarcinoma is dismal. Hence, advances in multidisciplinary treatment strategies, including surgery, are urgently needed. Early recurrence of distant organ metastases suggests that there are occult metastases even in cases with resectable disease. Several randomized controlled trials on adjuvant chemotherapy have been conducted to prolong survival after resection. CONKO-001 study was the first to demonstrate significant improvement in disease-free survival after surgery with gemcitabine administration. The JASPAC-01 study showed the superiority of adjuvant S1 over gemcitabine in survival after resection. Based on the results, adjuvant S1 therapy is the prescribed standard of care in Japan. Recently, the PRODIGE 24/CCTG PA.6 study showed that survival of patients treated with a modified FOLFIRINOX regimen as adjuvant therapy was significantly longer than those treated with adjuvant gemcitabine therapy. Although the evidence from these trials on adjuvant chemotherapy have been the gold-standard treatment for curatively resected and fully recovered patients, resectable disease at diagnosis is not the status, resected disease after curative resection. Currently, neoadjuvant therapy is considered to be a promising alternative to surgery for pancreatic cancer. Although there are many reports regarding neoadjuvant chemoradiotherapy, so far there has been no solid evidence proving the advantage of this strategy versus standard up-front surgery. Newly obtained results from the Prep-02/JSAP05 randomized phase II/III study, comparing neoadjuvant therapy with up-front surgery, revealed significant improvement in overall survival with neoadjuvant chemotherapy by intention-to-treat analysis. Thus, neoadjuvant intervention might become a new standard strategy in cases undergoing planned resection for pancreatic cancer.

  889. 膵癌化学療法中に顆粒球コロニー刺激因子製剤による大動脈炎を発症した1例 Peer-reviewed

    宮崎 健人, 高舘 達之, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　47　(5)　851-853　2020/05

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  890. 正中腹壁瘢痕ヘルニアに対するendoscopic component separation法を併施したIPOM-plusの有用性 Peer-reviewed

    市川 英孝, 青木 豪, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　25　(3)　210-216　2020/05

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  891. 空腸血管腫からの出血と鑑別を要した最重症再生不良性貧血に合併したMeckel憩室出血の1手術例 Peer-reviewed

    市川 英孝, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 藤島 史喜, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　40　(4)　567-570　2020/05

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  892. 【進行胆道癌・膵癌の治療限界を打ち破る-症例から学ぶ究極の治療-】胆嚢癌の外科治療 Peer-reviewed

    三浦 孝之, 中川 圭, 益田 邦洋, 元井 冬彦, 海野 倫明

    胆と膵　41　(5)　435-441　2020/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  893. [A Case of Aortitis Caused by a Granulocyte-Colony-Stimulating Factor during Chemotherapy for Pancreatic Cancer]. Peer-reviewed

    Kento Miyazaki, Tatsuyuki Takadate, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　47　(5)　851-853　2020/05

    ISSN： 0385-0684

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    BACKGROUND: Pegfilgrastim, a long-acting granulocyte-colony-stimulating factor(G-CSF), has been used as prophylaxis for severe hematotoxicity induced by chemotherapy. We report a case of aortitis induced by pegfilgrastim administration during modified FOLFIRINOX(mFOLFIRINOX)chemotherapy for metastatic pancreatic cancer. CASE REPORT: A 65-year-old woman underwent a distal pancreatectomy for pancreatic tail cancer. Liver metastases appeared 2 years after the surgery. mFOLFIRINOX chemotherapy was started with prophylactic administration of pegfilgrastim. Eight days after the first administration and 6 days after administration of the 8th course, the patient developed a fever. The blood test results indicated severe inflammation. Computed tomography revealed a thickened aorta indicating aortitis. The symptoms rapidly improved with antibiotic therapy. We diagnosed aortitis induced by pegfilgrastim administration. CONCLUSION: Aortitis should be considered when a patient has unidentified inflammatory findings after receiving pegfilgrastim.

  894. Impact of resection margin status on survival in pancreatic cancer patients after neoadjuvant treatment and pancreatoduodenectomy. International-journal Peer-reviewed

    Shimpei Maeda, Alexandra M Moore, Lavanya Yohanathan, Tatsuo Hata, Mark J Truty, Rory L Smoot, Sean P Cleary, David M Nagorney, Travis E Grotz, Eugene J Park, Mark D Girgis, Howard A Reber, Fuyuhiko Motoi, Toshiro Masuda, Michiaki Unno, Michael L Kendrick, Timothy R Donahue

    Surgery　167　(5)　803-811　2020/05

    DOI： 10.1016/j.surg.2019.12.008 　

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    BACKGROUND: Resection margin status has been recognized as an independent prognostic factor on overall survival in pancreatic cancer patients undergoing surgical resection. However, its impact after neoadjuvant treatment remains uncertain. METHODS: We analyzed 305 patients with resectable or borderline resectable pancreatic cancer treated with neoadjuvant therapy and pancreatoduodenectomy at 3 tertiary referral centers between 2010 and 2017. Positive resection margin was defined as 1 or more cancer cells at any margin. Overall survival was measured from the date of surgery until death or last follow-up. RESULTS: One hundred and seventy-eight patients received neoadjuvant chemotherapy and 127 received neoadjuvant chemoradiotherapy. The median overall survival was 29.8 months. The 1-, 3-, and 5-year overall survival rates were 79.2%, 44.0%, and 23.5%, respectively. Negative margin was achieved in 275 (90.2%) patients. Negative margin resection patients had a significantly longer overall survival than positive resection margin patients (31.3 vs 16.3 months, P < .001). In univariate analyses, overall survival was associated with age, margin status, histologic grade, ypT, number of positive lymph nodes, perineural invasion, treatment effect, postoperative carbohydrate antigen 19-9, and adjuvant therapy. Positive margin resection, poorly differentiated carcinoma, treatment effect score of 3, postoperative carbohydrate antigen 19-9 of 37 U/mL or higher, and lack of adjuvant therapy were predictive of poor overall survival in multivariate Cox regression analysis. CONCLUSION: Margin status was an independent predictor of overall survival in patients treated with neoadjuvant therapy and pancreatoduodenectomy, supporting the use of a negative margin resection as a surrogate of adequate oncological resection in this setting. Our findings may also have significant implications for patient stratification in future randomized trials.

  895. Prognostic indicators in pancreatic cancer patients undergoing total pancreatectomy. Peer-reviewed

    Shimpei Maeda, Kyohei Ariake, Masahiro Iseki, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　50　(5)　490-498　2020/05

    DOI： 10.1007/s00595-019-01924-4 　

    ISSN： 0941-1291

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    PURPOSE: To evaluate the long-term outcomes of total pancreatectomy in a modern cohort of pancreatic cancer patients and to establish whether any factors identified prior to pancreatic resection were related to poor survival. METHODS: We analyzed, retrospectively, patients who underwent total pancreatectomy for pancreatic cancer between 2007 and 2016. The short- and long-term outcomes were investigated and Cox regression analysis was used to evaluate the prognostic factors identified before resection. RESULTS: The subjects were 49 patients with a mean age of 65 years, who underwent total pancreatectomy in our hospital during the study period. Peritoneal washing cytology was performed in 48 patients, with positive results in 4 (8.3%). There was no 30-day mortality. The median overall survival was 22.5 months, with a 5-year survival rate of 28.5%. Univariate analyses of the pre-resection variables revealed that overall survival was associated with tumor location, resectability classification, maximum standardized uptake value of positron emission tomography, the preoperative carbohydrate antigen 19-9 level, and peritoneal washing cytology status. Multivariate analysis revealed that positive peritoneal washing cytology status and the maximum standardized uptake value were independent predictors of poor survival. CONCLUSION: Total pancreatectomy for pancreatic cancer is appropriate for selected patients, but peritoneal washing cytology and positron emission tomography should be performed preoperatively.

  896. Intraductal papillary neoplasms of the bile duct consist of two distinct types specifically associated with clinicopathological features and molecular phenotypes. International-journal Peer-reviewed

    Yasutaka Aoki, Masamichi Mizuma, Tatsuo Hata, Takeshi Aoki, Yuko Omori, Yusuke Ono, Yusuke Mizukami, Michiaki Unno, Toru Furukawa

    The Journal of pathology　251　(1)　38-48　2020/05

    DOI： 10.1002/path.5398 　

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    Intraductal papillary neoplasm of the bile duct (IPNB) is a grossly visible papillary biliary neoplasm with morphological variations and occasional invasion. Recently a new classification of IPNB into type 1 and type 2 was proposed in which the type 1 IPNBs consist of fine papillary neoplastic glands and the type 2 IPNBs consist of complex branching glands, seldom with foci of solid-tubular components. However, clinicopathological and molecular characteristics of these types of IPNBs are yet to be identified. We aimed to uncover clinicopathological and molecular characteristics of the types of IPNBs. Thirty-six IPNBs were studied retrospectively. Clinicopathological features as well as molecular alterations of 31 genes were evaluated by means of targeted next-generation sequencing and immunohistochemical examination of expression of mucin and cancer-associated molecules. The 36 IPNBs were classified into 22 of type 1 and 14 of type 2. The type 1 IPNBs were associated with a non-invasive phenotype, intestinal and oncocytic subtypes, development in the intrahepatic bile duct, overt mucin production, and a relatively good prognosis. The type 2 IPNBs were associated with an invasive phenotype, the pancreatobiliary subtype, development within the extrahepatic bile duct, and worse prognosis compared with the type 1 IPNBs. In the molecular analysis, recurrent mutations were found in TP53 (34.3%), KRAS (31.4%), STK11 (25.7%), CTNNB1 (17.1%), APC (14.3%), SMAD4 (14.3%), GNAS (11.4%), PBRM1 (11.4%), ELF3 (8.6%), KMT2C (8.6%), NF1 (8.6%), PIK3CA (8.6%), ARID1A (5.7%), ARID2 (5.7%), BAP1 (5.7%), BRAF (5.7%), EPHA6 (5.7%), ERBB2 (5.7%), ERBB3 (5.7%), KMT2D (5.7%), and RNF43 (5.7%). Mutations in KRAS and GNAS were enriched in the type 1 IPNBs, whereas mutations in TP53, SMAD4, and KMT2C were enriched in the type 2 IPNBs. These results indicate that IPNBs consist of two distinct types of neoplasms specifically associated with clinicopathological features and molecular phenotypes. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  897. 【術前・術後管理必携2020】術式別術前・術後管理 膵・脾 膵頭部癌に対する膵頭十二指腸切除術 Peer-reviewed

    前田 晋平, 海野 倫明

    消化器外科　43　(5)　699-705　2020/04

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  898. 【切除可能膵癌の診断と治療】切除可能膵癌に対する術前補助化学療法 Peer-reviewed

    海野 倫明

    日本消化器病学会雑誌　117　(4)　297-301　2020/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  899. The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer. International-journal Peer-reviewed

    Jun Sato, Hideaki Karasawa, Takashi Suzuki, Shun Nakayama, Munetoshi Katagiri, Shimpei Maeda, Shinobu Ohnuma, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Cancer investigation　38　(4)　214-227　2020/04

    DOI： 10.1080/07357907.2020.1741604 　

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    Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and MAPK signaling pathways in vitro, and decreased tumor growth and lymph node metastasis in vivo. Cripto-1 could be a useful prognostic biomarker and therapeutic target in colorectal cancer.

  900. CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells. International-journal Peer-reviewed

    Yuuri Hatsuzawa, Kazunori Yamaguchi, Tomoka Takanashi, Ikuro Sato, Keiichi Tamai, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Jun Yasuda, Masamichi Mizuma, Michiaki Unno, Kazuo Sugamura

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　20　(3)　493-500　2020/04

    DOI： 10.1016/j.pan.2020.01.013 　

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    BACKGROUND: Accumulating evidence indicates that CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is highly expressed in human epithelial carcinomas of multiple organs including the pancreas, but its functional role in carcinoma development has not yet been fully clarified. The aim of this study was to investigate the role of CD109 in the malignancy of pancreatic ductal adenocarcinoma (PDAC). METHODS: PDAC specimens of 145 cases were immunostained for CD109, and correlations between CD109 expression and clinicopathological conditions were analyzed. CD109 expression in PANC-1 cells, a PDAC-derived cell line, was decreased by siRNA or shRNA and its effect on the malignancy of PANC-1 cells was examined. RESULTS: Suppression of CD109 expression in PANC-1 cells resulted in reduction of in vitro cell motility and tumorigenicity in xenografts. Based on these results, we investigated the relationship between CD109 expression and metastasis of PDAC using tumor tissue specimens. Among 106 recurrent cases of 145 PDAC, there was a tendency for CD109-positive cases to be accompanied by distant metastasis. CONCLUSIONS: CD109 plays a critical role in the promotion of tumorigenic ability and cellular motility relating to metastasis of PDAC cells.

  901. BACH1 Promotes Pancreatic Cancer Metastasis by Repressing Epithelial Genes and Enhancing Epithelial-Mesenchymal Transition. International-journal Peer-reviewed

    Masaki Sato, Mitsuyo Matsumoto, Yuriko Saiki, Mahabub Alam, Hironari Nishizawa, Masahiro Rokugo, Andrey Brydun, Shinji Yamada, Mika K Kaneko, Ryo Funayama, Mamoru Ito, Yukinari Kato, Keiko Nakayama, Michiaki Unno, Kazuhiko Igarashi

    Cancer research　80　(6)　1279-1292　2020/03/15

    DOI： 10.1158/0008-5472.CAN-18-4099 　

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    Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the poorest prognoses due to its highly malignant features. BTB and CNC homology 1 (BACH1) has been implicated in RAS-driven tumor formation. We focused on the role of BACH1 in PDAC, more than 90% of which have KRAS mutation. Knockdown of BACH1 in PDAC cell lines reduced cell migration and invasion, in part, by increasing E-cadherin expression, whereas its overexpression showed opposite effects. BACH1 directly repressed the expression of FOXA1 that is known to activate the expression of CDH1 encoding E-cadherin and to inhibit epithelial-to-mesenchymal transition. BACH1 also directly repressed the expression of genes important for epithelial cell adhesion including CLDN3 and CLDN4. In a mouse orthotopic implantation model, BACH1 was required for the high metastatic ability of AsPC-1 cells. IHC analysis of clinical specimens with a newly developed anti-BACH1 mAb revealed that high expression of BACH1 is a poor prognostic factor. These results suggest that the gene regulatory network of BACH1 and downstream genes including CDH1 contribute to the malignant features of PDAC by regulating epithelial-to-mesenchymal transition. SIGNIFICANCE: Greater understanding of the gene regulatory network involved in epithelial-to-mesenchymal transition of pancreatic cancer cells will provide novel therapeutic targets and diagnostic markers.

  902. 高齢者における腹腔鏡補助下噴門側胃切除術の治療成績(Outocome of laparoscopically assisted proximal gastrectomy in elderly patients)

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　92回　259-259　2020/03

    Publisher: (一社)日本胃癌学会

  903. 胃癌の腹腔鏡下幽門側胃切除における血管走行破格(Vascular anomaly in laparoscopic distal gastrectomy for gastric cancer)

    青木 豪, 武者 宏昭, 田中 直樹, 井本 博文, 山村 明寛, 亀井 尚, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　92回　285-285　2020/03

    Publisher: (一社)日本胃癌学会

  904. 噴切後の十二指腸液逆流による難治性逆流性食道炎に対してduodenal switchを施行した1例(Duodenal switch for reflux esophagitis due to duodenal juice reflux after proximal gastrectomy)

    田中 直樹, 武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 齊藤 真弘, 小池 智幸, 正宗 淳, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　92回　479-479　2020/03

    Publisher: (一社)日本胃癌学会

  905. Organoid培養と遺伝子解析を用いた膵胆道癌の個別化医療モデルの確立

    椎原 正尋, 石川 智彦, 碇 直樹, 樋口 亮太, 元井 冬彦, 山本 雅一, 海野 倫明, 古川 徹

    日本病理学会会誌　109　(1)　296-296　2020/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  906. 高齢者における腹腔鏡補助下噴門側胃切除術の治療成績(Outocome of laparoscopically assisted proximal gastrectomy in elderly patients)

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　92回　259-259　2020/03

    Publisher: (一社)日本胃癌学会

  907. 胃癌の腹腔鏡下幽門側胃切除における血管走行破格(Vascular anomaly in laparoscopic distal gastrectomy for gastric cancer)

    青木 豪, 武者 宏昭, 田中 直樹, 井本 博文, 山村 明寛, 亀井 尚, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　92回　285-285　2020/03

    Publisher: (一社)日本胃癌学会

  908. 噴切後の十二指腸液逆流による難治性逆流性食道炎に対してduodenal switchを施行した1例(Duodenal switch for reflux esophagitis due to duodenal juice reflux after proximal gastrectomy)

    田中 直樹, 武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 齊藤 真弘, 小池 智幸, 正宗 淳, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　92回　479-479　2020/03

    Publisher: (一社)日本胃癌学会

  909. IPMN組織亜型における遺伝子異常についての相互関係の分子病理学的解析

    小林 敏一, 大森 優子, 小野 裕介, 水上 裕輔, 牧野 直彦, 元井 冬彦, 海野 倫明, 上野 義之, 古川 徹

    日本病理学会会誌　109　(1)　324-324　2020/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  910. STK11 plays a canonical role in malignant progression of a subset of KRAS-mutant IPMNs(和訳中)

    大森 優子, 小野 裕介, 森川 孝則, 元井 冬彦, 樋口 亮太, 山本 雅一, 唐崎 秀則, 水上 裕輔, 海野 倫明, 古川 徹

    日本病理学会会誌　109　(1)　324-324　2020/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  911. 【IBDに合併する悪性腫瘍の診断と治療Update!】クローン病合併がん(直腸肛門部・小腸がん)の特徴とサーベイランス法 Peer-reviewed

    渡辺 和宏, 福島 浩平, 大沼 忍, 海野 倫明

    IBD Research　14　(1)　25-30　2020/03

    Publisher: (株)先端医学社

    ISSN： 1881-6533

  912. 【内視鏡下採取検体を用いた膵疾患バイオマーカー探索】膵嚢胞液中バイオマーカー解析による悪性度診断 Peer-reviewed

    畠 達夫, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    胆と膵　41　(3)　293-299　2020/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  913. Neoadjuvant treatment for resectable pancreatic adenocarcinoma: What is the best protocol? Peer-reviewed

    Fuyuhiko Motoi, Michiaki Unno

    Annals of gastroenterological surgery　4　(2)　100-108　2020/03

    DOI： 10.1002/ags3.12311 　

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    Although upfront surgery has been the gold standard for pancreatic adenocarcinoma that is planned for resection, it should be compared with the alternative strategy of neoadjuvant therapy. Despite the many reports of the efficacy of neoadjuvant therapy, most of them were not comparative. Recently Prep-02/JSAP05 study clearly demonstrated the significant survival benefit of neoadjuvant chemotherapy over upfront surgery for pancreatic adenocarcinoma that is planned for resection. These findings opened a new chapter of neoadjuvant therapy. Ongoing trials are expected to confirm the evidence. This review summarizes the past, present, and future perspectives of neoadjuvant therapy and its optimization.

  914. 【一般・消化器外科医のための できる! 漢方】周術期を漢方でサポートする 上部消化管手術 腹腔鏡下幽門側胃切除術後管理への六君子湯の導入効果 Peer-reviewed

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    臨床外科　75　(3)　292-298　2020/03

    Publisher: (株)医学書院

    ISSN： 0386-9857

    eISSN： 1882-1278

  915. 【内視鏡下採取検体を用いた膵疾患バイオマーカー探索】膵嚢胞液中バイオマーカー解析による悪性度診断 Peer-reviewed

    畠 達夫, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    胆と膵　41　(3)　293-299　2020/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  916. Early postoperative drainage fluid culture positivity from contaminated bile juice is predictive of pancreatic fistula after pancreaticoduodenectomy. Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Kei Nakagawa, Kunihiro Masuda, Masaharu Ishida, Takanori Morikawa, Hiroki Hayashi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　50　(3)　248-257　2020/03

    DOI： 10.1007/s00595-019-01885-8 　

    ISSN： 0941-1291

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    PURPOSE: To investigate the impact of early postoperative drainage fluid culture positivity on the development of clinically relevant postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD). METHODS: We assessed the positive prevalence, distribution, and drug sensitivity of microorganisms in drainage fluid collected on postoperative day (POD) 1 after PD from 465 patients. RESULTS: Culture results were positive in pancreaticojejunostomy (PJ) drainage fluid from 26.0% of patients. Similar distributions of microorganisms were observed in the bile juice and PJ/hepaticojejunostomy (HJ) drainage fluid from these patients. PJ drain culture positivity was associated with an elevated drainage amylase level and with preoperative biliary drainage. No associations were seen between HJ drainage culture positivity and the drainage amylase and bilirubin levels. PJ drainage culture positivity was found to be an independent predictor of grade B/C POPF. According to the antibiogram, the bacteria identified were likely to be resistant to prophylactic antibiotics. CONCLUSIONS: PJ drainage culture positivity on POD 1 in combination with an elevated drainage amylase level is an early predictor of grade B/C POPF. PJ drainage culture positivity may be attributable to bile juice contamination caused by intraoperative spillage and early postoperative leakage from the PJ anastomotic sites.

  917. 消化管出血に対するStrategy 出血を契機に発見された小腸腫瘍性病変に対する外科治療戦略

    大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　269-269　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  918. 炎症性腸疾患の緊急手術における術式選択と治療成績 潰瘍性大腸炎に対する結腸亜全摘症例の特徴と合併症

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　279-279　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  919. 肝胆膵領域術後出血に対する治療戦略 膵頭十二指腸切除術術後出血の治療戦略

    森川 孝則, 水間 正道, 青木 修一, 畠 達夫, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 高瀬 圭, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　266-266　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  920. Video-assisted retroperitoneal debridementを施行した壊死性膵炎の1例

    三田地 克昂, 前田 晋平, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　314-314　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  921. 【肝・胆・膵がんの薬物療法】膵がん 切除可能膵がんに対する術前・術後化学療法 Peer-reviewed

    元井 冬彦, 海野 倫明

    腫瘍内科　25　(2)　167-173　2020/02

    Publisher: (有)科学評論社

    ISSN： 1881-6568

  922. Prediction of the Probability of Malignancy in Mucinous Cystic Neoplasm of the Pancreas With Ovarian-Type Stroma: A Nationwide Multicenter Study in Japan. International-journal Peer-reviewed

    Takao Ohtsuka, Masafumi Nakamura, Susumu Hijioka, Yasuhiro Shimizu, Michiaki Unno, Minoru Tanabe, Yuichi Nagakawa, Kyoichi Takaori, Seiko Hirono, Naoto Gotohda, Wataru Kimura, Kei Ito, Akio Katanuma, Tsuyoshi Sano, Takahiro Urata, Emiri Kita, Keiji Hanada, Minoru Tada, Takeshi Aoki, Masahiro Serikawa, Kojun Okamoto, Hiroyuki Isayama, Yoshitaka Gotoh, Kousei Ishigami, Hiroshi Yamaguchi, Kenji Yamao, Masanori Sugiyama, Kazuichi Okazaki

    Pancreas　49　(2)　181-186　2020/02

    DOI： 10.1097/MPA.0000000000001475 　

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    OBJECTIVE: The aim of the study was to develop a formula for predicting the probability of malignancy of mucinous cystic neoplasm (MCN) of the pancreas with ovarian-type stroma. METHODS: A total of 364 patients were enrolled. A total score was calculated as the sum of the approximate integers of the odds ratios of the predictive factors identified by multivariate analysis. The relationship between the total score and pathological results was assessed. RESULTS: A total of 321 patients had benign MCN and 43 had malignant MCN. Five possible predictive factors were analyzed: 56 years or older, high serum carcinoembryonic antigen level, high carbohydrate antigen 19-9 level, tumor size of 51 mm or greater, and the presence of mural nodules. The total score was significantly higher in patients with malignant MCN (median, 24; range, 0-37) compared with benign MCN (median, 5; range, 0-33; P < 0.001). Receiver operating characteristic curve analysis demonstrated that the area under the curve was 0.86, and the sensitivity and specificity of the total score for discriminating malignant MCNs were 72% and 83%, respectively, using a cut-off value of 22. CONCLUSIONS: The current simple formula can predict the malignancy of MCN and may thus contribute to the adequate management of patients with MCN.

  923. 肝胆膵領域術後出血に対する治療戦略 膵頭十二指腸切除術術後出血の治療戦略 Peer-reviewed

    森川 孝則, 水間 正道, 青木 修一, 畠 達夫, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 高瀬 圭, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　266-266　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  924. 消化管出血に対するStrategy 出血を契機に発見された小腸腫瘍性病変に対する外科治療戦略 Peer-reviewed

    大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　269-269　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  925. 炎症性腸疾患の緊急手術における術式選択と治療成績 潰瘍性大腸炎に対する結腸亜全摘症例の特徴と合併症 Peer-reviewed

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 梶原 大輝, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　279-279　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  926. Video-assisted retroperitoneal debridementを施行した壊死性膵炎の1例 Peer-reviewed

    三田地 克昂, 前田 晋平, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　40　(2)　314-314　2020/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  927. Factors associated with, and interventions to reduce, fatigue experienced by patients three months after pancreatectomy Peer-reviewed

    Rio MINAMI, Naoko SATO, Fuyuhiko MOTOI, Fumiko SATO, Michiaki UNNO

    Suizo　35　(1)　83-90　2020/02

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.35.83 　

    ISSN： 0913-0071

    eISSN： 1881-2805

  928. A multicenter prospective registration study on laparoscopic pancreatectomy in Japan: report on the assessment of 1,429 patients. Peer-reviewed

    Takao Ohtsuka, Yuichi Nagakawa, Hirochika Toyama, Yutaka Takeda, Atsuyuki Maeda, Yusuke Kumamoto, Yoshiharu Nakamura, Kazuki Hashida, Goro Honda, Kengo Fukuzawa, Eiji Toyoda, Minoru Tanabe, Naoto Gotohda, Ippei Matsumoto, Tomoki Ryu, Ichiro Uyama, Toru Kojima, Michiaki Unno, Daisuke Ichikawa, Yosuke Inoue, Hiroyoshi Matsukawa, Takeshi Sudo, Kyoichi Takaori, Hiroki Yamaue, Susumu Eguchi, Munenori Tahara, Makoto Shinzeki, Hidetoshi Eguchi, Masanao Kurata, Mamoru Morimoto, Hiromitsu Hayashi, Shigeru Marubashi, Masafumi Inomata, Kenjiro Kimura, Koji Amaya, Masayuki Sho, Ryuichi Yoshida, Akihiro Murata, Hideyuki Yoshitomi, Kenichi Hakamada, Masafumi Yasunaga, Nobutsugu Abe, Masayoshi Hioki, Masaru Tsuchiya, Takeyuki Misawa, Yasuji Seyama, Hirokazu Noshiro, Eiji Sakamoto, Kiyoshi Hasegawa, Yasunari Kawabata, Yoichiro Uchida, Shinichiro Kameyama, Saiho Ko, Takashi Takao, Kenji Kitahara, Shin Nakahira, Hideo Baba, Masahiko Watanabe, Masakazu Yamamoto, Masafumi Nakamura

    Journal of hepato-biliary-pancreatic sciences　27　(2)　47-55　2020/02

    DOI： 10.1002/jhbp.695 　

    ISSN： 1868-6974

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    BACKGROUND: Prospective studies are needed to understand the safety and feasibility of laparoscopic pancreatectomy. The aim of the present study was to describe laparoscopic pancreatectomy currently undertaken in Japan, using a prospective registration system. METHODS: Patient characteristics and planned operations were registered preoperatively, and then the performed operation and outcomes were reported using an online system. Collected data were also compared between institutions based on their level of experience. This study was registered with UMIN000022836. RESULTS: Available data were obtained from 1,429 patients at 100 Japanese institutions, including 1,197 laparoscopic distal pancreatectomies (LDPs) and 232 laparoscopic pancreatoduodenectomies (LPDs). The rates of completion for planned operations were 92% for LDP and 91% for LPD. Postoperative complication rates after LDP and LPD were 17% and 30%, and 90-day mortality rates were 0.3% and 0.4%, respectively. Shorter operation time, less blood loss, and lower incidence of pancreatic fistula were observed in institutions experienced in LDP. A higher rate of pure laparoscopic procedure and shorter operation time were noted in institutions experienced with LPD. CONCLUSION: LDPs and LPDs are performed safely in Japan, especially in experienced institutions. Our data could support the next challenges in the field of laparoscopic pancreatectomy.

  929. Preoperative biliary drainage of the hepatic lobe to be resected does not affect liver hypertrophy after percutaneous transhepatic portal vein embolization. International-journal Peer-reviewed

    Shin Miura, Atsushi Kanno, Koji Fukase, Yu Tanaka, Ryotaro Matsumoto, Tatsuhide Nabeshima, Seiji Hongou, Tetsuya Takikawa, Shin Hamada, Kiyoshi Kume, Kazuhiro Kikuta, Kei Nakagawa, Michiaki Unno, Atsushi Masamune

    Surgical endoscopy　34　(2)　667-674　2020/02

    DOI： 10.1007/s00464-019-06813-y 　

    ISSN： 0930-2794

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    BACKGROUND: In patients with malignant perihilar biliary strictures, preoperative biliary drainage (PBD) of the hepatic lobe to be resected may decrease the liver volume of the future liver remnant (FLR) after percutaneous transhepatic portal vein embolization (PVE). However, evidence of its application is insufficient. This study aimed to clarify the effects of PBD on liver hypertrophy after PVE. METHODS: Between January 2008 and December 2017, 169 patients with malignant perihilar biliary strictures underwent major hepatectomy or palliative surgery at our hospital. Of these, 76 patients who underwent PVE were categorized into two groups: group A (n = 29) who received unilateral PBD of the FLR and group B (n = 47) who received bilateral PBD, including that of the hepatic lobe to be resected. FLR ratios after PVE and liver hypertrophy ratios were retrospectively compared in both groups. RESULTS: Group B exhibited significantly severe biliary stenosis (p = 0.0038) and high serum bilirubin before biliary drainage (p = 0.0037). After PVE, the total liver volumes were 1287 ± 260 ml and 1340 ± 257 ml (p = 0.39), respectively. FLR volumes were 555 ± 135 and 577 ± 113 ml (p = 0.45), respectively. FLR ratios were 43.4 ± 8.2% and 43.4 ± 6.4%, respectively (p = 0.98). Liver hypertrophy ratios were 124.2 ± 17.7% and 129.2 ± 20.9%, respectively (p = 0.28). In addition, an examination which excluded patients with Bismuth type I obtained similar result. CONCLUSIONS: PBD of the hepatic lobe to be resected did not decrease the FLR ratios and hypertrophy ratios. Thus, in patients with poor biliary drainage, additional PBD of the target lobe is acceptable.

  930. The superior approach with the stomach roll-up technique improves intraoperative outcomes and facilitates learning laparoscopic distal pancreatectomy: a comparative study between the superior and inferior approach. Peer-reviewed

    Takanori Morikawa, Masaharu Ishida, Tatsuyuki Takadate, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Hideo Ohtsuka, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　50　(2)　153-162　2020/02

    DOI： 10.1007/s00595-019-01855-0 　

    ISSN： 0941-1291

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    PURPOSE: We introduced a superior approach and a unique technique to retract the stomach, called the "stomach roll-up technique", to standardize laparoscopic distal pancreatectomy and increase educational effectiveness. The aim of this study was to evaluate the clinical outcomes of these procedures. METHODS: Forty-five patients who underwent laparoscopic distal pancreatectomy by surgeons-in-training between January 2015 and December 2018 were included. Twenty laparoscopic distal pancreatectomies were performed using the inferior approach, and 25 procedures were performed using the superior approach. The stomach roll-up technique was used in all cases. The perioperative outcomes were retrospectively analyzed. RESULTS: Compared with the inferior approach, the superior approach was associated with a significantly shorter operation time (p < 0.001) and lower estimated blood loss (p = 0.011), and these differences were not affected by the exclusion of cases with conversion or concomitant procedures. In the univariate analysis adjusted for other covariates, a lower body mass index (p = 0.045), pancreatic tail tumor (p = 0.0178) and the superior approach (p = 0.0176) were significantly associated with a shorter operation time. CONCLUSION: The superior approach with the stomach roll-up technique is simple and will aid in educating surgeons on performing laparoscopic distal pancreatectomy.

  931. Characteristics and predictive value for graft fibrosis of the complement-binding capacity of donor-specific human leukocyte antigen antibodies after pediatric liver transplantation. International-journal Peer-reviewed

    Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Pediatric transplantation　24　(1)　e13648　2020/02

    DOI： 10.1111/petr.13648 　

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    BACKGROUND: Donor-specific HLA antibodies (DSAs) have detrimental effects on short- and long-term outcomes after organ transplantation. Despite evidence that the complement-binding capacity of DSAs has predictive power in kidney transplantation, its clinical impact during long-term follow-up after LT remains unclear. In this study, we assessed the complement-binding capacities of DSAs and their association with histological findings. METHODS: In total, 72 patients who underwent pediatric LT at our institution between July 1991 and October 2013 were retrospectively reviewed. A subgroup analysis of histological findings was performed for 37 subjects who underwent liver graft biopsy. Patients were divided into two groups based on the degree of graft fibrosis, and clinical characteristics were assessed. RESULTS: All anti-class I DSAs were C1q-negative. Anti-DR and anti-DQ DSAs were identified in 34% and 41% of patients, respectively; however, only three of 25 patients with anti-DR DSAs exhibited a positive C1q-binding assay, whereas, 25 of 29 anti-DQ DSAs showed C1q-binding capacity. MFI values for DSA were significantly higher for patients with C1q-binding capacity than for those without (P < .0001). Complement-binding anti-DR DSA was relatively rare in both groups. Regarding anti-DQ DSA, there were no differences between fibrosis and non-fibrosis groups, irrespective of complement-binding capacity. CONCLUSIONS: The association between anti-DR DSA and liver fibrosis, which was supported in this cohort, was not strengthened but rather impaired when accounting for complement-binding capacity due to low positive detection. Further studies of the association between complement-binding anti-DQ DSA and histological findings in LT are needed.

  932. Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review. Peer-reviewed

    Shingo Yoshimachi, Hideo Ohtsuka, Takeshi Aoki, Takayuki Miura, Kyohei Ariake, Kunihiro Masuda, Masaharu Ishida, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Atsushi Kanno, Atsushi Masamune, Fumiyoshi Fujishima, Hironobu Sasano, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Clinical journal of gastroenterology　13　(1)　37-45　2020/02

    DOI： 10.1007/s12328-019-01009-2 　

    ISSN： 1865-7257

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    Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor composed of both adenocarcinoma and neuroendocrine components. Here, we report the case of a 75-year-old woman with ampullary MANEC. She visited a physician with the chief complaint of dark urine and was diagnosed with advanced jaundice. Subsequently, she was referred to our hospital. Contrast-enhanced computed tomography scan revealed a neoplastic lesion measuring approximately 2 cm with a contrast effect at the duodenal papilla. Upper endoscopy showed a non-exposed tumor at the duodenal papilla. After biliary drainage, a subtotal stomach-preserving pancreaticoduodenectomy was performed. Histopathological examination revealed that the tumor components were composed of circular-to-oval atypical cells admixed with tubular adenocarcinoma tissue. These atypical cells were immunohistochemically positive for synaptophysin and diagnosed as neuroendocrine carcinoma with a Ki-67 labeling index of 63%. The patient was diagnosed with MANEC with a neuroendocrine carcinoma component of approximately 40%. The neuroendocrine carcinoma component had metastasized to the posterior pancreatic lymph nodes. Despite starting adjuvant chemotherapy with S-1, computed tomography revealed the presence of multiple liver metastases within 4 months after surgery. MANEC with neuroendocrine carcinoma is well known to have an extremely poor prognosis. Therefore, establishing a multidisciplinary therapy including chemotherapy is crucial.

  933. Risk model for severe postoperative complications after total pancreatectomy based on a nationwide clinical database. International-journal Peer-reviewed

    D Hashimoto, M Mizuma, H Kumamaru, H Miyata, A Chikamoto, H Igarashi, T Itoi, S Egawa, Y Kodama, S Satoi, S Hamada, K Mizumoto, H Yamaue, M Yamamoto, Y Kakeji, Y Seto, H Baba, M Unno, T Shimosegawa, K Okazaki

    The British journal of surgery　2020/01/31

    DOI： 10.1002/bjs.11437 　

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    BACKGROUND: Total pancreatectomy is required to completely clear tumours that are locally advanced or located in the centre of the pancreas. However, reports describing clinical outcomes after total pancreatectomy are rare. The aim of this retrospective observational study was to assess clinical outcomes following total pancreatectomy using a nationwide registry and to create a risk model for severe postoperative complications. METHODS: Patients who underwent total pancreatectomy from 2013 to 2017, and who were recorded in the Japan Society of Gastroenterological Surgery and Japanese Society of Hepato-Biliary-Pancreatic Surgery database, were included. Severe complications at 30 days were defined as those with a Clavien-Dindo grade III needing reoperation, or grade IV-V. Occurrence of severe complications was modelled using data from patients treated from 2013 to 2016, and the accuracy of the model tested among patients from 2017 using c-statistics and a calibration plot. RESULTS: A total of 2167 patients undergoing total pancreatectomy were included. Postoperative 30-day and in-hospital mortality rates were 1·0 per cent (22 of 2167 patients) and 2·7 per cent (58 of 167) respectively, and severe complications developed in 6·0 per cent (131 of 2167). Factors showing a strong positive association with outcome in this risk model were the ASA performance status grade and combined arterial resection. In the test cohort, the c-statistic of the model was 0·70 (95 per cent c.i. 0·59 to 0·81). CONCLUSION: The risk model may be used to predict severe complications after total pancreatectomy.

  934. A Case of Initially Locally Advanced Pancreatic Cancer Curatively Resected after Carbon-Ion Radiotherapy with Gemcitabine

    Miyazaki, K., Hayashi, H., Ishida, M., Ohtsuka, H., Mizuma, M., Nakagawa, K., Morikawa, T., Motoi, F., Kamei, T., Shinoto, M., Yamada, S., Takiyama, H., Unno, M.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy　47　(13)　2020

    ISSN： 0385-0684

  935. 切除不能膵癌に対するConversion surgeryにおいて、術前治療後のGlasgow Prognostic Scoreが有意な予後予測因子となる

    國米 崇, 青木 修一, 畠 達夫, 三浦 孝之, 高館 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 海野 倫明

    外科と代謝・栄養　54　(5)　115-115　2020

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  936. 当院における腎動脈瘤に対するex vivo surgeryの検討

    土田 憲, 後藤 均, 赤松 大二朗, 菅原 宏文, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 小笠原 紀信, 高橋 宏和, 亀井 尚, 海野 倫明, 梅津 道久

    日本血管外科学会雑誌　29　(Suppl.)　OP31-2　2020

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  937. 幽門側胃切除後に発症した食道アカラシアにPOEMを施行した1例

    安藤 涼平, 佐藤 千晃, 谷山 裕亮, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　208回　147-147　2020/01

    Publisher: 日本消化器病学会-東北支部

  938. 在宅看護師が持つ在宅ストーマケアの課題

    柴崎 真澄, 熊谷 英子, 舟山 裕士, 石川 奈津江, 大網 さおり, 大内 淑子, 小野 友美, 木幡 真利子, 蛭田 理絵, 村田 博子, 神山 篤史, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　36　(1)　197-197　2020/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  939. 在宅看護師のためのストーマケア講習会の有効性と課題

    熊谷 英子, 柴崎 真澄, 舟山 裕士, 石川 奈津江, 大網 さおり, 大内 淑子, 小野 友美, 木幡 真利子, 蛭田 理恵, 村田 博子, 神山 篤史, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　36　(1)　200-200　2020/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  940. 高齢者に対する術前栄養指標から見た膵癌周術期成績

    森川 孝則, 林 洋毅, 水間 正道, 吉町 信吾, 青木 修一, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

    外科と代謝・栄養　54　(5)　112-112　2020

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  941. 肝癌治療の最前線 肝機能障害を有する肝癌に対する腹腔鏡下肝切除術の検討

    宇根 範和, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　208回　71-71　2020/01

    Publisher: 日本消化器病学会-東北支部

  942. 低侵襲検査・治療(消化管) 我が国における病的肥満症・糖尿病に対する外科治療の現状

    井本 博文, 田中 直樹, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器病学会東北支部例会プログラム・抄録集　208回　75-75　2020/01

    Publisher: 日本消化器病学会-東北支部

  943. 低侵襲検査・治療(肝胆膵) 膵胆道疾患に対する腹腔鏡下手術 現状と展望

    森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　208回　89-89　2020/01

    Publisher: 日本消化器病学会-東北支部

  944. 病理診断の臨床診療への関わり 膵癌の術前病期診断 審査腹腔鏡による微小転移の病理診断

    高舘 達之, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　208回　101-101　2020/01

    Publisher: 日本消化器病学会-東北支部

  945. 【必見!肝胆膵臨床を変えたランドマークスタディ】膵臓 RCTによる膵癌術前術後化学療法開発の歴史 Peer-reviewed

    元井 冬彦, 海野 倫明

    肝・胆・膵　80　(1)　125-131　2020/01

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  946. Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma. International-journal Peer-reviewed

    Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno

    PloS one　15　(7)　e0235904　2020

    DOI： 10.1371/journal.pone.0235904 　

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    Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis. Here, we used proteomics to identify proteins associated with lymph-node metastasis, which is one of the prognostic factors. We selected lymph node metastasis-positive and -negative patients (n = 5 each) who underwent pancreatectomy between 2005 and 2015 and subjected to comprehensive proteomic profiling of tumor stroma. A total of 490 proteins were detected by mass spectrometry. Software analysis revealed that nine of these proteins were differentially expressed between the two patient groups. We focused on hemopexin and ferritin light chain based on immunohistochemistry results. We assessed the clinicopathological data of 163 patients and found that hemopexin expression was associated with UICC N2 (p = 0.0399), lymph node ratio (p = 0.0252), venous invasion (p = 0.0096), and lymphatic invasion (p = 0.0232). Notably, in vitro assays showed that hemopexin promotes invasion of the pancreatic cancer cells. Our findings suggest that hemopexin is a lymph node metastasis-associated protein that could potentially serve as a useful therapeutic target or biomarker of pancreatic ductal adenocarcinoma.

  947. 化学療法が奏効し膀胱を温存し得た膀胱浸潤直腸癌の1切除例 Peer-reviewed

    小久保 翔志, 唐澤 秀明, 梶原 大輝, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　47　(1)　135-137　2020/01

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  948. 【IPMN・MCN国際診療ガイドライン総まとめ】縮小手術 Peer-reviewed

    石田 晶玄, 森川 孝則, 高館 達之, 元井 冬彦, 内藤 剛, 海野 倫明

    胆と膵　41　(1)　59-64　2020/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  949. 後腹膜腫瘍切除後椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症I型の1救命例 Peer-reviewed

    三浦 孝之, 水間 正道, 元井 冬彦, 内藤 剛, 亀井 尚, 高瀬 圭, 海野 倫明

    Japanese Journal of Acute Care Surgery　9　(2)　254-257　2020/01

    Publisher: 日本Acute Care Surgery学会

    eISSN： 2436-102X

  950. 救命し得ず剖検でCMV感染が判明した多発小腸潰瘍の1例 Peer-reviewed

    井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    Japanese Journal of Acute Care Surgery　9　(2)　272-276　2020/01

    Publisher: 日本Acute Care Surgery学会

    eISSN： 2436-102X

  951. 直腸癌術後のストーマトラブルにおける危険因子の検討 Peer-reviewed

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 大沼 忍, 高橋 真紀, 渡辺 涼子, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　36　(1)　205-205　2020/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  952. 萎縮細径腸管に対する東北大式吻合によるストーマ閉鎖手技 Peer-reviewed

    渡辺 和宏, 大沼 忍, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 渡邊 涼子, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　36　(1)　269-269　2020/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

    eISSN： 2434-3056

  953. [Bladder-Sparing Surgery with Preoperative Chemotherapy for Rectal Cancer with Urinary Bladder Involvement-A Case Report]. Peer-reviewed

    Shoji Kokubo, Hideaki Karasawa, Taiki Kajiwara, Shinobu Ohnuma, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　47　(1)　135-137　2020/01

    ISSN： 0385-0684

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    A 65-year-old male was diagnosed with rectal cancer invading the urinary bladder, swollen para-aorticlymph nodes, and multiple liver metastases in abdominal CT. After 8 courses of mFOLFOX6 plus panitumumab, the rectal cancer, para-aortic lymph nodes metastasis, and liver metastases decreased significantly in size. Rectal cancer and liver metastases were considered resectable, hence low anterior resection of the rectum was performed. Intraoperative frozen section analysis showed negative metastaticinvolvement of the para-aorticlymph nodes and surgical margins of the urinary bladder; therefore, the urinary bladder was completely preserved. Partial resection of the liver was performed 2 months later. In conclusion, the patient showed good surgical and quality of life results. Thus, the bladder-sparing strategy with preoperative chemotherapy could be considered for appropriately selected rectal cancer patients with urinary bladder involvement.

  954. 東北大学病院における小児肝移植の現状と今後の課題

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 柿崎 裕太, 福岡 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019/12

    Publisher: (一社)日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  955. 高齢者胃癌に対する腹腔鏡下胃切除術 高齢者における腹腔鏡下幽門側胃切除術の治療成績

    武者 宏昭, 梶原 大輝, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 大沼 忍, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　WS2-4　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  956. スリーブ状胃切除術の問題点 腹腔鏡下スリーブ状胃切除術後通過障害に対するrevision surgery

    井本 博文, 田中 直樹, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　WS34-9　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  957. F3-4肝線維化に対する腹腔鏡下肝切除の安全性について

    宇根 範和, 藤尾 淳, 高舘 達之, 石田 晶玄, 戸子台 和哲, 森川 孝則, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF011-3　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  958. 高度肝硬変を有する肝細胞癌に対する腹腔鏡下肝切除の検討

    藤尾 淳, 宮城 重人, 宇根 範和, 中西 渉, 高舘 達之, 戸子台 和哲, 石田 晶玄, 森川 孝則, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF011-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  959. 潰瘍性大腸炎に対する腹腔鏡下大腸全摘回腸嚢肛門吻合術の短期治療成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 大沼 忍, 武者 宏昭, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF062-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  960. 当院における病的肥満症に対する腹腔鏡下スリーブ状胃切除術の治療成績

    市川 英孝, 井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　MO008-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  961. 当科における腹腔鏡下スリーブバイパス術の治療成績

    上野 知尭, 井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　MO008-3　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  962. 当科における進行胃癌に対する腹腔鏡下幽門側胃切除術の導入

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO110-1　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  963. 肥満合併大腸癌に対する腹腔鏡手術の工夫

    唐澤 秀明, 田中 直樹, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO138-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  964. 直腸癌に対するロボット手術の短期成績

    大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO150-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  965. 腹腔鏡下S状結腸切除術におけるCo-axial settingの有用性

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO161-6　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  966. 胃GISTに対する腹腔鏡術式の選択

    青木 豪, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO243-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  967. 肥満外科手術のノウハウを活かした肥満症例に対する腹腔鏡手術の工夫 簡便・確実なポート創閉鎖

    田中 直樹, 武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO305-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  968. 肝胆膵領域における腹腔鏡下手術の画像支援 術前シミュレーション画像を利用した、腹腔鏡下膵尾側切除術における術中ナビゲーション

    石田 晶玄, 森川 孝則, 高舘 達之, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 青木 豪, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　WS41-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  969. 胆嚢癌疑診症例に対する腹腔鏡下胆嚢摘出術の適応

    伊関 雅裕, 高舘 達之, 畠 達夫, 三浦 孝之, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF009-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  970. 担癌患者の急性胆嚢炎に対する治療方針の検討

    高舘 達之, 森川 孝則, 石田 晶玄, 伊関 雅裕, 畠 達夫, 三浦 孝之, 川口 桂, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF045-5　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  971. 安全な導入・普及を念頭に置いた、腹腔鏡補助下膵頭十二指腸切除術

    森川 孝則, 石田 晶玄, 高舘 達之, 伊関 雅裕, 畠 達夫, 三浦 孝之, 青木 豪, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF079-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  972. 長期成績を念頭に置いた、腹腔鏡下肝外胆管切除・肝管空腸結節吻合術

    森川 孝則, 石田 晶玄, 高舘 達之, 伊関 雅裕, 三浦 孝之, 川口 桂, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO167-4　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  973. 食道癌内視鏡手術のアプローチ法(胸腔鏡vs縦隔鏡) 胸腔鏡下食道切除術における側臥位・腹臥位アプローチそれぞれの利点と課題

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 高屋 快, 福富 俊明, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　PD10-5　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  974. 胸腔鏡下食道切除術における術中左反回神経持続モニタリングを使用した左上縦隔リンパ節郭清

    高屋 快, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 氏家 直人, 今野 卓朗, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF003-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  975. 術後再発を減らすための腹腔鏡下食道裂孔ヘルニア修復術の工夫

    佐藤 千晃, 氏家 直人, 今野 卓朗, 福富 俊明, 岡本 宏史, 高屋 快, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF072-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  976. 【膵癌治療の進歩】局所進行膵癌に対する腫瘍マーカーを指標とした集学的外科治療戦略 Peer-reviewed

    元井 冬彦, 海野 倫明

    消化器外科　42　(13)　1803-1813　2019/12

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  977. [Conversion Surgery for Locally Advanced Unresectable Pancreatic Cancer Treated with FOLFIRINOX Therapy and Proton Beam Therapy Combined with S-1 Chemotherapy-A Case Report]. Peer-reviewed

    Yuichiro Umino, Masamichi Mizuma, Masahiro Iseki, Tatsuo Hata, Tatsuyuki Takadate, Kei Kawaguchi, Takeshi Aoki, Fuyuhiko Motoi, Takeshi Naito, Takashi Kamei, Atsushi Masamune, Chikashi Ishioka, Takashi Ono, Masao Murakami, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(13)　1928-1930　2019/12

    ISSN： 0385-0684

    More details Close

    We report a case of locally advanced unresectable(UR-LA)pancreatic cancer in a patient who underwent conversion surgery after FOLFIRINOX and proton beam therapy(PBT)combined with S-1. A 68-year-old woman was referred to our hospital for a pancreatic tumor. The abdominal CT scan revealed a 40mm pancreatic body tumor with an abutment(>180°) of the celiac artery and the superior mesenteric artery. Moreover, the tumor was classified as UR-LA with a contact to the abdominal aorta. The tumor was histologically diagnosed as adenocarcinoma via an endoscopic ultrasound-guided fine-nee- dle aspiration. After 2 courses of FOLFIRINOX, PBT(50 GyE/25 Fr)combined with S-1 were administered. The tumor shrunk to 30mm at the CT scan. After 5 courses of FOLFIRINOX, the tumor reduced to 20 mm. No distant metastasis or malignant cells in abdominal washing cytology was detected using staging laparoscopy. Then, distal pancreatectomy with celiac axis resection(DP-CAR)was performed. According to the General Rules for the Study of Pancreatic Cancer(7th edition)from Japan Pancreas Society, the histological findings were suggestive of ypT3, ypN0, R0, and Grade 3 histological effect. The patient had a Grade A delayed gastric emptying post-operation. He was discharged 35 days after the surgery and has been alive without recurrence on imaging for 11 months post-operation.

  978. 膵臓がん周術期の栄養不良例の臨床的特徴 Peer-reviewed

    元井 冬彦, 畠 達夫, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 中川 圭, 亀井 尚, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(4)　216-226　2019/12

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  979. FOLFIRINOX療法とS-1併用陽子線治療後にConversion切除を施行した局所進行切除不能膵癌の1例 Peer-reviewed

    海野 裕一郎, 水間 正道, 伊関 雅裕, 畠 達夫, 高舘 達之, 川口 桂, 青木 豪, 元井 冬彦, 内藤 剛, 亀井 尚, 正宗 淳, 石岡 千加史, 小野 崇, 村上 昌雄, 海野 倫明

    癌と化学療法　46　(13)　1928-1930　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  980. 術前診断に難渋した膵尾部平滑筋肉腫の1例 Peer-reviewed

    三田地 克昂, 石田 晶玄, 大森 優子, 古川 徹, 有明 恭平, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    癌と化学療法　46　(13)　2167-2169　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  981. 術前化学放射線療法後に側方リンパ節の一つに腫瘍細胞が残存していた進行下部直腸癌の1切除例 Peer-reviewed

    田山 穂高, 唐澤 秀明, 梶原 大輝, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　46　(13)　2348-2350　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  982. 直腸粘液腺癌局所再発に対して術前化学放射線療法後にR0切除を行った1例 Peer-reviewed

    佐藤 圭佑, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　46　(13)　2440-2442　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  983. 小腸GISTの腹膜転移に対してイマチニブが奏効したが部分耐性を認め切除した1例 Peer-reviewed

    小野 翼, 田中 直樹, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　46　(13)　2452-2454　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  984. 食道癌内視鏡手術のアプローチ法(胸腔鏡vs縦隔鏡) 胸腔鏡下食道切除術における側臥位・腹臥位アプローチそれぞれの利点と課題 Peer-reviewed

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 高屋 快, 福富 俊明, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　PD10-5　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  985. 高齢者胃癌に対する腹腔鏡下胃切除術 高齢者における腹腔鏡下幽門側胃切除術の治療成績 Peer-reviewed

    武者 宏昭, 梶原 大輝, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 大沼 忍, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　WS2-4　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  986. スリーブ状胃切除術の問題点 腹腔鏡下スリーブ状胃切除術後通過障害に対するrevision surgery Peer-reviewed

    井本 博文, 田中 直樹, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　WS34-9　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  987. 肝胆膵領域における腹腔鏡下手術の画像支援 術前シミュレーション画像を利用した、腹腔鏡下膵尾側切除術における術中ナビゲーション Peer-reviewed

    石田 晶玄, 森川 孝則, 高舘 達之, 畠 達夫, 伊関 雅裕, 三浦 孝之, 有明 恭平, 青木 豪, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　WS41-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  988. 胸腔鏡下食道切除術における術中左反回神経持続モニタリングを使用した左上縦隔リンパ節郭清 Peer-reviewed

    高屋 快, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 氏家 直人, 今野 卓朗, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF003-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  989. 胆嚢癌疑診症例に対する腹腔鏡下胆嚢摘出術の適応 Peer-reviewed

    伊関 雅裕, 高舘 達之, 畠 達夫, 三浦 孝之, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF009-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  990. F3-4肝線維化に対する腹腔鏡下肝切除の安全性について Peer-reviewed

    宇根 範和, 藤尾 淳, 高舘 達之, 石田 晶玄, 戸子台 和哲, 森川 孝則, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF011-3　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  991. 高度肝硬変を有する肝細胞癌に対する腹腔鏡下肝切除の検討 Peer-reviewed

    藤尾 淳, 宮城 重人, 宇根 範和, 中西 渉, 高舘 達之, 戸子台 和哲, 石田 晶玄, 森川 孝則, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF011-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  992. 担癌患者の急性胆嚢炎に対する治療方針の検討 Peer-reviewed

    高舘 達之, 森川 孝則, 石田 晶玄, 伊関 雅裕, 畠 達夫, 三浦 孝之, 川口 桂, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF045-5　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  993. 潰瘍性大腸炎に対する腹腔鏡下大腸全摘回腸嚢肛門吻合術の短期治療成績 Peer-reviewed

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 大沼 忍, 武者 宏昭, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF062-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  994. 術後再発を減らすための腹腔鏡下食道裂孔ヘルニア修復術の工夫 Peer-reviewed

    佐藤 千晃, 氏家 直人, 今野 卓朗, 福富 俊明, 岡本 宏史, 高屋 快, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　24　(7)　SF072-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  995. 安全な導入・普及を念頭に置いた、腹腔鏡補助下膵頭十二指腸切除術 Peer-reviewed

    森川 孝則, 石田 晶玄, 高舘 達之, 伊関 雅裕, 畠 達夫, 三浦 孝之, 青木 豪, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　SF079-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  996. 当院における病的肥満症に対する腹腔鏡下スリーブ状胃切除術の治療成績 Peer-reviewed

    市川 英孝, 井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　MO008-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  997. 当科における腹腔鏡下スリーブバイパス術の治療成績 Peer-reviewed

    上野 知尭, 井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　24　(7)　MO008-3　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  998. 当科における進行胃癌に対する腹腔鏡下幽門側胃切除術の導入 Peer-reviewed

    山村 明寛, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 梶原 大輝, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO110-1　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  999. 肥満合併大腸癌に対する腹腔鏡手術の工夫 Peer-reviewed

    唐澤 秀明, 田中 直樹, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO138-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1000. 直腸癌に対するロボット手術の短期成績 Peer-reviewed

    大沼 忍, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO150-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1001. 腹腔鏡下S状結腸切除術におけるCo-axial settingの有用性 Peer-reviewed

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO161-6　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1002. 長期成績を念頭に置いた、腹腔鏡下肝外胆管切除・肝管空腸結節吻合術 Peer-reviewed

    森川 孝則, 石田 晶玄, 高舘 達之, 伊関 雅裕, 三浦 孝之, 川口 桂, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO167-4　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1003. 胃GISTに対する腹腔鏡術式の選択 Peer-reviewed

    青木 豪, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO243-2　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1004. 肥満外科手術のノウハウを活かした肥満症例に対する腹腔鏡手術の工夫 簡便・確実なポート創閉鎖 Peer-reviewed

    田中 直樹, 武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　24　(7)　MO305-7　2019/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1005. [Pancreatic Leiomyosarcoma with a Difficult Preoperative Diagnosis-A Case Report]. Peer-reviewed

    Katsutaka Mitachi, Masaharu Ishida, Yuko Omori, Toru Furukawa, Kyohei Ariake, Kunihiro Masuda, Hideo Ohtsuka, Masamichi Mizuma, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Takeshi Naitoh, Takashi Kamei, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(13)　2167-2169　2019/12

    ISSN： 0385-0684

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    A 43-year-old man was referred to our hospital for examination of a pancreatic tumor. Imaging revealed a mass-like lesion with a cyst in the pancreatic tail. Histological examination by EUS-FNA showed a low grade spindle cell lesion for which laparoscopic distal pancreatectomy was performed. The neoplasm was histologically diagnosed as pancreatic leiomyosarcoma. The postoperative course was uneventful and no signs of recurrence at 8 months after the surgery. Pancreatic leiomyosarcoma is very rare. Only 7 previous cases were reported in Japan. In tumors with diameters exceeding 50 mm, bleeding and necrosis occur inside the tumor and a cyst-like form often develops, which is considered a characteristic imaging finding. Therefore, imaging is important for preoperative differential diagnosis of the disease.

  1006. [A Case of Solitary Residual Lateral Pelvic Lymph Node Metastasis Despite Complete Response of Primary Rectal Cancer Followed by Neoadjuvant Chemoradiotherapy]. Peer-reviewed

    Hodaka Tayama, Hideaki Karasawa, Taiki Kajiwara, Shinobu Ohnuma, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(13)　2348-2350　2019/12

    ISSN： 0385-0684

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    A 45-year-old woman was referred to our hospital complaining of diarrhea. Colonoscopy showed a rectal tumor. Histological examination showed moderately differentiated adenocarcinoma. A CT scan revealed a tumor extending from the lower rectum to the anal canal with a lateral pelvic lymph node(LPLN)swelling. We administered neoadjuvant chemoradiotherapy (45 Gy/25 Fr, S-1 80mg/m / 2/day)and the tumor and LPLN shrank remarkably, with a clinically complete response by CT and PET-CT. We then performed abdominoperineal resection with D3 lymph node and bilateral LPLN dissection. Pathological examination revealed complete disappearance of the cancer cells in the primary site, while lymph node metastasis was detected in one LPLN. We report here a rare case in which LPLN metastasis remained despite the pathological complete response of the primary tumor.

  1007. [A Case of Curatively Resected Locally Recurrent Rectal Mucinous Adenocarcinoma Followed by Preoperative Chemoradiotherapy]. Peer-reviewed

    Keisuke Sato, Hideaki Karasawa, Taiki Kajiwara, Hideyuki Suzuki, Atsushi Kohyama, Kazuhiro Watanabe, Shinobu Ohnuma, Takanori Ishida, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(13)　2440-2442　2019/12

    ISSN： 0385-0684

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    A 60s man was diagnosed with rectal cancer and underwent low anterior resection of the rectum. The pathological diagnosis was mucinous adenocarcinoma, pT3(SS), pN0, pM0, pStage Ⅱ. Two years after the primary surgery, contrast-enhanced CT showed local recurrence on the oral side of the anastomosis. As the tumor had invaded the left seminal vesicle and coccygeus muscle, neoadjuvant chemoradiotherapy(NACRT)(S-1 80mg/m / 2 plus 45 Gy/25 Fr)was performed. After NACRT, abdominoperineal resection, including the left seminal vesicle, coccygeus muscle, and coccygeal bone, was performed. Pathological examination showed a histological response of Grade 2 and that R0 resection was achieved. Although the only radical treatment of locally recurrent rectal cancer is R0 resection, we performed R0 resection with Grade 2 histological response to NACRT.

  1008. [A Case of Peritoneal Metastasis Resection from GIST of the Small Intestine with Focal Resistance Against Imatinib Mesylate]. Peer-reviewed

    Tasuku Ono, Naoki Tanaka, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Hideaki Karasawa, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Shinobu Ohnuma, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(13)　2452-2454　2019/12

    ISSN： 0385-0684

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    A 69-year-old man was referred to our institute for the surgical resection of focal resistant peritoneal GIST during imatinib administration. He had been diagnosed with GIST of the small intestine with liver and peritoneal metastases, and imatinib treatment was initiated. Shortly after imatinib administration, the primary lesion perforated, and thus, partial resection of the small intestine was performed. Imatinib treatment was resumed after the first surgery, and he achieved partial response. However, computed tomography scans obtained 7 months after the first surgery showed focal progression, a peritoneal metastasis near the right kidney. Under the diagnosis of focally imatinib-resistant GIST, local resection of the metastatic tumor was performed. In this case, an exon 11 mutation of c-kit was noted initially. After the imatinib treatment, an additional point mutation was observed in exon 18 that caused resistance to imatinib. Therefore, imatinib treatment was reinitiated after the second surgery, and other metastases were well controlled. In case of GIST with multiple metastases, appropriate treatment should be selected based on the resistance of each lesion.

  1009. 東北大学病院における小児肝移植の現状と今後の課題 Peer-reviewed

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 柿崎 裕太, 福岡 健吾, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 亀井 尚, 海野 倫明

    日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019/12

    Publisher: 日本小児栄養消化器肝臓学会

    ISSN： 1346-9037

  1010. Prognostic importance of peritoneal washing cytology in patients with otherwise resectable pancreatic ductal adenocarcinoma who underwent pancreatectomy: A nationwide, cancer registry-based study from the Japan Pancreas Society. International-journal Peer-reviewed

    Hiroyoshi Tsuchida, Tsutomu Fujii, Masamichi Mizuma, Sohei Satoi, Hisato Igarashi, Hidetoshi Eguchi, Tamotsu Kuroki, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshihisa Tsuji, Yoshiki Hirooka, Atsushi Masamune, Kazuhiro Mizumoto, Takao Itoi, Shinichi Egawa, Yuzo Kodama, Shin Hamada, Michiaki Unno, Hiroki Yamaue, Kazuichi Okazaki

    Surgery　166　(6)　997-1003　2019/12

    DOI： 10.1016/j.surg.2019.06.023 　

    ISSN： 0039-6060

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    BACKGROUND: The importance of peritoneal washing cytology status both as a sign of irresectability and as a prognostic factor for pancreatic ductal adenocarcinoma remains controversial. The purpose of this nationwide, cancer registry-based study was to clarify the clinical implications of operative resection in patients who had positive cytology status. METHODS: Clinical data from 1,970 patients who underwent tumor resection were collected from the Pancreatic Cancer Registry in Japan. Clinicopathologic factors and overall survival curves were analyzed, and multivariate Cox proportional hazard models were evaluated. RESULTS: Among the 1,970 patients analyzed, positive cytology status was found in 106 patients and negative cytology status was found in 1,864 patients. The positive cytology status group had a greater frequency of pancreatic body and tail cancer and greater preoperative serum carbohydrate antigen 19-9 levels than the negative cytology status group (P < .001 each). The ratio of peritoneal recurrence tended to be greater in the positive cytology status group (14% vs 43%; P < .001). Overall median survival times were less in the positive cytology status group (17.5 months vs 29.4 months; P < .001). The 5-year survival rates were 13.7% and 31.1% in the positive cytology status and negative cytology status groups, respectively. Multivariate analysis of positive cytology status patients revealed that adjuvant chemotherapy was an independent prognostic factor. CONCLUSION: Positive cytology status was an adverse prognostic factor in patients who underwent resection for pancreatic ductal adenocarcinoma but did not preclude attempted curative resection. Curative resection followed by adjuvant chemotherapy may contribute to long-term prognosis in patients with positive cytology status.

  1011. The Influence of the Perioperative Nutritional Status on the Survival Outcomes for Esophageal Cancer Patients with Neoadjuvant Chemotherapy. International-journal Peer-reviewed

    Makoto Hikage, Yusuke Taniyama, Tadashi Sakurai, Chiaki Sato, Kai Takaya, Hiroshi Okamoto, Takuro Konno, Naoto Ujiie, Takeshi Naitoh, Michiaki Unno, Takashi Kamei

    Annals of surgical oncology　26　(13)　4744-4753　2019/12

    DOI： 10.1245/s10434-019-07742-9 　

    ISSN： 1068-9265

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    BACKGROUND: Studies have shown a variety of nutritional indices to be prognostic predictors for esophageal cancer patients. However, which nutritional index should be used and when it should be measured during the perioperative period remain unclear. This study attempted to clarify the details surrounding predictive nutritional evaluation by assessing the longitudinal data of serologic indices in perioperative esophageal cancer patients. METHODS: The study included 141 esophageal cancer patients who underwent neoadjuvant chemotherapy after radical esophagectomy at Tohoku University Hospital from April 2008 to December 2017. The nutritional status was retrospectively assessed during the perioperative period, and the prognostic factors related to survival were analyzed. RESULTS: Use of the controlling nutritional status (CONUT) score showed that malnutrition occurred only from 14 days after surgery in most cases. Use of the prognostic nutritional index (PNI) showed that the ratio of malnutrition increased gradually from presurgery to 14 days after surgery. The timing of malnutrition that affected survival was 14 days after surgery with the CONUT score and presurgery and 4 months after surgery with the PNI. A multivariable analysis of independent prognostic factors predicting survival identified malnutrition 14 days after surgery with the CONUT score and a low PNI before surgery, invasion depth of the primary lesion, and node metastasis. CONCLUSIONS: Malnutrition occurring during the perioperative state of esophageal cancer was shown to be a survival prognostic factor. Development of an optimal nutritional intervention is recommended for esophageal cancer patients to prevent malnutrition both before and after surgery.

  1012. 膵臓がん周術期の栄養不良例の臨床的特徴 Peer-reviewed

    元井 冬彦, 畠 達夫, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 中川 圭, 亀井 尚, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(4)　216-226　2019/12

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1013. 術前診断に難渋した膵尾部平滑筋肉腫の1例 Peer-reviewed

    三田地 克昂, 石田 晶玄, 大森 優子, 古川 徹, 有明 恭平, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    癌と化学療法　46　(13)　2167-2169　2019/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1014. Collagen gel droplet-embedded culture drug sensitivity test (CD-DST) predicts the effect of adjuvant chemotherapy on pancreatic cancer. Peer-reviewed

    Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Hideo Ohtsuka, Hiroki Hayashi, Kei Nakagawa, Tatsuo Hata, Katsutaka Mitachi, Takeshi Naitoh, Takashi Kamei, Michiaki Unno

    Surgery today　49　(12)　1035-1043　2019/12

    DOI： 10.1007/s00595-019-01842-5 　

    ISSN： 0941-1291

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    PURPOSE: We evaluated the clinical effectiveness of collagen gel droplet-embedded culture drug sensitivity tests (CD-DSTs) in predicting the efficacy of adjuvant chemo-therapeutic treatments for pancreatic cancer (PC). METHODS: The clinicopathological characteristics and prognoses of 22 PC patients who underwent CD-DST after pancreatectomy at Tohoku University between 2012 and 2016 were analyzed retrospectively. Eligibility criteria were resectable or borderline resectable PC, successful evaluation for 5-fluorouracil sensitivity by CD-DST, treatment with S-1 adjuvant chemotherapy, and no preoperative chemotherapy. RESULTS: The rate of successful evaluation by CD-DST was 52.3% in PC. The optimal T/C ratio, defined as the ratio of the number of cancer cells in the treatment group (T) to that in the control group (C), for 5-fluorouracil was 85% using receiver operating characteristic curve analysis. The sensitive group (T/C ratio < 85%; n = 11) had a better recurrence-free survival rate than the resistant group (T/C ratio ≥ 85%; n = 11; P = 0.029). A Cox proportional hazards regression model demonstrated that sensitivity to 5-fluorouracil was an independent predictor of recurrence on multivariate analysis (hazard ratio 3.28; 95.0% CI 1.20-9.84; P = 0.020). CONCLUSIONS: CD-DSTs helped to predict PC recurrence after S-1 adjuvant chemotherapy.

  1015. Conversion surgery for positive peritoneal washing cytology in pancreatic cancer. International-journal Peer-reviewed

    Katsutaka Mitachi, Kyohei Ariake, Fuyuhiko Motoi, Michiaki Unno

    BMJ case reports　12　(11)　2019/11/21

    DOI： 10.1136/bcr-2019-229993 　

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    Positive peritoneal washing cytology (PPC) of pancreatic carcinoma is defined as distant metastasis in the American Joint Committee on Cancer or Union for International Cancer Control's tumour, node, metastases classification. However, surgical resection was believed to be the only method that prolong survival; thus, many institutions perform pancreatectomy for PPC, despite the unfavourable prognosis. Therefore, a more preferable alternative treatment for PPC is required. A 64-year-old man with resectable pancreatic tail cancer presented to our hospital. PPC was detected at first laparotomy; thus, pancreatectomy was avoided and gemcitabine with nabpaclitaxel (GnP) was administered. After four courses of GnP treatment, PPC converted to negative, as evaluated by abdominal port cytology. Thus, distal pancreatectomy was performed, and R0 resection was achieved. He has been healthy for more than 24 months since the first laparotomy. Initial chemotherapy with the intention of converting the cytological status followed by surgical treatment might become a useful treatment strategy for PPC.

  1016. ストーマサイトとストーマ関連腸閉塞の関連性

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 武者 宏昭, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　52　(Suppl.2)　190-190　2019/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1017. 先天性胆道拡張症、膵・胆管合流異常術後肝内結石の治療

    大塚 英郎, 伊関 雅裕, 畠 達夫, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　52　(Suppl.2)　217-217　2019/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1018. 膵癌の長期予後に術後合併症が及ぼす影響

    水間 正道, 元井 冬彦, 林 洋毅, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    日本消化器外科学会雑誌　52　(Suppl.2)　247-247　2019/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1019. 周術期栄養状態の変化からみた高齢者に対する膵全摘

    伊関 雅裕, 水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　52　(Suppl.2)　248-248　2019/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1020. 膵癌の長期予後に術後合併症が及ぼす影響

    水間 正道, 元井 冬彦, 林 洋毅, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    日本消化器外科学会雑誌　52　(Suppl.2)　247-247　2019/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1021. 消化器領域の難治癌の臨床 胆管癌の手術適応と集学的治療

    中川 圭, 益田 邦洋, 海野 倫明

    日本消化器病学会雑誌　116　(臨増大会)　A499-A499　2019/11

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1022. Surgery Todayにおける利益相反管理 Peer-reviewed

    海野 倫明

    日本外科学会雑誌　120　(6)　746-748　2019/11

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1023. 【肝胆膵領域における低侵襲手術】ロボット支援肝胆道手術の現状と将来展望 Peer-reviewed

    森川 孝則, 内藤 剛, 石田 晶玄, 高舘 達之, 亀井 尚, 海野 倫明

    外科　81　(12)　1254-1257　2019/11

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  1024. 【術前治療時代の膵癌診断・治療戦略】術前治療時代の膵癌治療戦略 Peer-reviewed

    元井 冬彦, 海野 倫明

    胆と膵　40　(11)　949-955　2019/11

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1025. Survey of preoperative management protocol for perihilar cholangiocarcinoma at 10 Japanese high-volume centers with a combined experience of 2,778 cases. Peer-reviewed

    Rohan Jagat Chaudhary, Ryota Higuchi, Masato Nagino, Michiaki Unno, Masayuki Ohtsuka, Itaru Endo, Satoshi Hirano, Katsuhiko Uesaka, Kiyoshi Hasegawa, Toshifumi Wakai, Shinji Uemoto, Masakazu Yamamoto

    Journal of hepato-biliary-pancreatic sciences　26　(11)　490-502　2019/11

    DOI： 10.1002/jhbp.668 　

    More details Close

    BACKGROUND: In Japan, strategies for preoperative management of perihilar cholangiocarcinoma (PHC) have evolved over the last decade; the operative mortality has significantly reduced to <5%. METHODS: A questionnaire was sent to 10 institutions based on their case volume. Questionnaire was based on: (1) preoperative biliary drainage, (2) bile replacement, (3) role of synbiotics, (4) remnant liver volume enhancement, (5) predicted remnant liver function, (6) imaging, (7) nutrition, and (8) role of Inchinkoto. RESULTS: The median case volume was 226 (range 105-889) cases, respectively. Eight institutions preferred endoscopic nasobiliary drainage and two preferred endoscopic biliary stenting for biliary drainage. Nine used bile replacement within 2-3 days of biliary drainage. Four used synbiotics preoperatively. The median cutoff value for future remnant liver volume and serum total bilirubin, at which portal vein embolization (PVE) is done, is <40% and <4 mg/dl. The median interval between PVE and surgery was 3-4 weeks. To predict remnant liver function, indocyanine green retention (n = 8) and clearance rate (n = 2) were mainly used. Five used Inchinkoto to improve liver function. Nine used multidetector computed tomography and direct cholangiography for surgical planning. CONCLUSION: With appropriate preoperative management of PHC, surgical morbidity and mortality can be reduced. This survey can provide recommendations to improve PHC perioperative outcomes.

  1026. 【外科医とがん登録-NCDから見えてきたわが国のがん治療の実態-】膵がん登録 Peer-reviewed

    水間 正道, 海野 倫明, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 濱田 晋, 水元 一博, 下瀬川 徹, 岡崎 和一, 日本膵臓学会膵癌登録委員会

    日本外科学会雑誌　120　(6)　676-680　2019/11

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1027. 卒後15年目からの3年間の米国留学を通して

    吉松 軍平, 坂田 直昭, 長谷川 傑, 海野 倫明, 小玉 正太

    日本臨床外科学会雑誌　80　(増刊)　527-527　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1028. 消化管の情報発信-臓器間ネットワークと肥満- 胆汁酸の動態から見たMetabolic surgeryの作用機序

    田中 直樹, 井本 博文, 伊勢 一郎, 上野 知尭, 市川 英孝, 渡辺 和宏, 神山 篤史, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　161-161　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1029. 1型糖尿病合併病的肥満症患者に対して腹腔鏡下スリーブ状胃切除術を施行した1例

    市川 英孝, 井本 博文, 田中 直樹, 上野 知尭, 小野 翼, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　317-317　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1030. 腹腔鏡下スリーブ状胃切除術後の通過障害に対する治療戦略

    井本 博文, 田中 直樹, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　273-273　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1031. 胆嚢癌術前診断に応じた治療戦略 術中迅速診断を用いた胆嚢癌の術式選択

    伊関 雅裕, 中川 圭, 海野 倫明

    胆道　33　(3)　410-410　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1032. 肝門部領域胆管癌の手術適応と治療戦略

    中川 圭, 益田 邦洋, 吉町 信吾, 青木 修一, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    胆道　33　(3)　510-510　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1033. 胆嚢管に発生したintracholecystic papillary and tubular neoplasm(ICPTN)が総胆管に広範に進展・浸潤した一例

    青木 泰孝, 伊関 雅裕, 高舘 達之, 益田 邦洋, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    胆道　33　(3)　658-658　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1034. 膵癌患者の術前化学療法前後のFACT-Hepを用いたQOLおよび症状の変化

    佐藤 菜保子, 元井 冬彦, 伊関 雅裕, 川口 桂, 佐藤 冨美子, 片寄 友, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　P152-8　2019/10

    Publisher: (一社)日本癌治療学会

  1035. 若い力が切り拓く今後の細胞移植医療 羊膜由来幹細胞を用いた低侵襲細胞移植療法の確立

    戸子台 和哲, 伊藤 貴子, 沖田 ひとみ, 齋藤 昌利, 星合 哲郎, 山田 修平, 宮城 重人, 三木 敏生, 海野 倫明, 亀井 尚, 後藤 昌史

    Organ Biology　26　(3)　59-59　2019/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1036. 肝細胞移植の成績向上に寄与するグラフト生着促進因子の同定および機序の検討

    齋藤 純健, 稲垣 明子, 猪村 武弘, 後藤 めぐみ, Ibrahim Fathi, 西牧 宏泰, 小笠原 弘之, 宮城 重人, 海野 倫明, 亀井 尚, 安波 洋一, 後藤 昌史

    Organ Biology　26　(3)　119-119　2019/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1037. 肥満症専門医・生活習慣病改善指導士は高度肥満症とどう向き合うべきか? 高度肥満症に対する外科治療の有効性と問題点

    内藤 剛, 田中 直樹, 井本 博文, 海野 倫明

    肥満研究　25　(Suppl.)　174-174　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1038. 胆道癌ゲノム医療の最前線 Single cell sequenceを用いた肝内胆管癌における新規治療効果の解析

    青木 修一, 内藤 剛, 海野 倫明

    胆道　33　(3)　426-426　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1039. R0切除後CA19-9遷延上昇は、膵癌術後肝転移再発の高リスク徴候である

    元井 冬彦, 村上 義昭, 松本 逸平, 里井 壯平, 庄 雅之, 本田 五郎, 福本 巧, 青木 修一, 水間 正道, 山上 裕機, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　O49-3　2019/10

    Publisher: (一社)日本癌治療学会

  1040. 胆嚢癌の術前予後予測因子の重要性

    中川 圭, 畠 達夫, 三浦 孝之, 川口 桂, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　RT13-2　2019/10

    Publisher: (一社)日本癌治療学会

  1041. 膵胆管合流異常を伴う胆嚢Mixed adenoneuroendcrine carcinomaの1例

    佐野 貴紀, 菅野 敦, 田中 裕, 松本 諒太郎, 鍋島 立秀, 滝川 哲也, 三浦 晋, 林 洋毅, 益田 邦洋, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 敦

    胆道　33　(3)　673-673　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1042. ディベートセッション:最新のエビデンスに基づいた食道外科手術(開胸vs鏡視下) 胸部食道癌に対する標準術式としての胸腔鏡下食道切除術

    亀井 尚, 谷山 裕亮, 岡本 宏史, 佐藤 千晃, 高屋 快, 今野 卓朗, 氏家 直人, 及川 隆弘, 小関 健, 鳩山 恵一郎, 今野 裕司, 安藤 涼平, 篠崎 康晴, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　388-388　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1043. 胆嚢原発肝様腺癌の1例 Peer-reviewed

    佐野 貴紀, 菅野 敦, 田中 裕, 松本 諒太郎, 鍋島 立秀, 滝川 哲也, 三浦 晋, 森川 孝則, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 淳

    胆道　33　(4)　744-751　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1044. 高難度手術について考える(移植・肝胆膵・食道・直腸・小児外科・緊急手術) 胸腔鏡下食道切除術の左側における想定外の術中損傷と予防・対処法 Peer-reviewed

    谷山 裕亮, 岡本 宏史, 佐藤 千晃, 高屋 快, 福富 俊明, 今野 卓朗, 氏家 直人, 及川 隆洋, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　357-357　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1045. 肝胆膵外科領域におけるロボット支援手術の位置づけ 先天性胆管拡張症成人例に対するロボット支援腹腔鏡下肝外胆管切除術 Peer-reviewed

    森川 孝則, 内藤 剛, 石田 晶玄, 高舘 達之, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 元井 冬彦, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　376-376　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1046. 膵全摘手術の適応と周術期管理 高齢者に対する膵全摘術後の問題点と対策 Peer-reviewed

    伊関 雅裕, 水間 正道, 海野 裕一郎, 高舘 達之, 川口 桂, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　402-402　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1047. 長期予後が得られた症例1(上部消化管) StageIVa食道癌患者に対する集学的治療 長期生存例の経験から Peer-reviewed

    氏家 直人, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 及川 隆洋, 今野 卓朗, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　403-403　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1048. 術後合併症で苦しんだ症例1(上部消化管) 食道癌術後の胃管潰瘍による胃管心嚢瘻の1例 Peer-reviewed

    及川 隆洋, 篠崎 康晴, 今野 裕司, 氏家 直人, 今野 卓朗, 福富 俊明, 岡本 宏史, 高屋 快, 佐藤 千晃, 谷山 裕亮, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　405-405　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1049. 外科周術期管理における漢方医療の有効性 幽門側胃切除術後クリニカルパスへの六君子湯の導入の効果 Peer-reviewed

    武者 宏昭, 梶原 大輝, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　409-409　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1050. 食道手術における術後合併症予防を目指した手術手技の工夫と周術期管理のコツ ICG蛍光法を用いた胃管作成法とレーザードップラー血流計を用いた再建胃管血流評価の後方視的検討 Peer-reviewed

    福富 俊明, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 今野 卓郎, 氏家 直人, 及川 隆洋, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　410-410　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1051. 術後合併症で苦しんだ症例2(下部消化管) 血栓性微小血管障害症を合併し治療に難渋したS状結腸癌の1例 Peer-reviewed

    唐澤 秀明, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　413-413　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1052. 大血管に浸潤した悪性腫瘍の手術 腹腔動脈合併切除を伴う膵体尾部切除(DP-CAR)の治療成績 術前治療の安全性ならびに予後改善効果について Peer-reviewed

    林 洋毅, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　432-432　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1053. 膵頭十二指腸切除術後合併症により長期間の入院を要した症例の検討 Peer-reviewed

    大塚 英郎, 石田 晶玄, 三浦 孝之, 有明 恭平, 川口 景, 益田 邦洋, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　460-460　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1054. 一期的に食道切除・再建を施行した維持透析患者5例の検討 Peer-reviewed

    熊谷 卓朗, 谷山 裕亮, 佐藤 千晃, 高屋 快, 岡本 宏史, 福富 俊明, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　464-464　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1055. 肝胆膵高難度手術における血流保全とトラブルシューティング Peer-reviewed

    中川 圭, 益田 邦洋, 青木 修一, 高舘 達之, 有明 恭平, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　468-468　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1056. 家族性大腸腺腫症(Familial adenomatous polyposis:FAP)に対する外科治療と問題点 Peer-reviewed

    大沼 忍, 神山 篤史, 梶原 大輝, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　501-501　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1057. IPOM plus施行後の再発腹壁瘢痕ヘルニア Peer-reviewed

    青木 豪, 梶原 大輝, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 森川 孝則, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　521-521　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1058. 一時的双孔式回腸人工肛門に伴うoutlet obstructionについての検討 Peer-reviewed

    梶原 大輝, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　525-525　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1059. 海外留学から学んだこと 百聞は一見に如かず Peer-reviewed

    水間 正道, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　528-528　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1060. 食道癌術後の膵管内乳頭粘液性腫瘍に対してindocyanine green蛍光法により胃管の血流を評価し胃管温存膵頭十二指腸切除術を施行した1例 Peer-reviewed

    三頭 啓明, 西村 隆一, 藤尾 淳, 中西 渉, 宮城 重人, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　721-721　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1061. 超高齢者に発症した左胃大網動脈瘤破裂の1例 Peer-reviewed

    千葉 和治, 水間 正道, 林 洋毅, 畠 達夫, 伊関 雅裕, 高舘 達之, 川口 桂, 大塚 英郎, 森川 孝則, 中川 圭, 元井 冬彦, 亀井 尚, 内藤 剛, 高瀬 圭, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　809-809　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1062. エキノコッカス症による多発腹腔内包虫嚢胞の1例 Peer-reviewed

    西牧 宏泰, 中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　868-868　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1063. 家族性大腸腺腫症に対する術後症例の長期経過観察 Peer-reviewed

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 梶原 大輝, 武者 宏昭, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　O43-5　2019/10

    Publisher: (一社)日本癌治療学会

  1064. クローン病に合併する直腸肛門部癌の臨床病理学的特徴の検討 Peer-reviewed

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 梶原 大輝, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　O65-5　2019/10

    Publisher: (一社)日本癌治療学会

  1065. 膵神経内分泌腫瘍同時性肝転移における外科的介入例の検討 Peer-reviewed

    三浦 孝之, 青木 豪, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 笹野 公伸, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　O68-2　2019/10

    Publisher: (一社)日本癌治療学会

  1066. 膀胱浸潤大腸癌に対する抗EGFR抗体を用いた膀胱温存治療戦略 Peer-reviewed

    唐澤 秀明, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　P18-7　2019/10

    Publisher: (一社)日本癌治療学会

  1067. 直腸癌に対するロボット手術の短期成績 Peer-reviewed

    大沼 忍, 神山 篤史, 唐澤 秀明, 梶原 大輝, 鈴木 秀幸, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　57回　P74-3　2019/10

    Publisher: (一社)日本癌治療学会

  1068. 拡大肝葉切除・肝外胆管切除術後に生菌製剤の構成菌Clostridium butyricumによる菌血症を呈した2例 Peer-reviewed

    水間 正道, 中川 圭, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　16　(5)　565-565　2019/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  1069. 消化管の情報発信-臓器間ネットワークと肥満- 胆汁酸の動態から見たMetabolic surgeryの作用機序 Peer-reviewed

    田中 直樹, 井本 博文, 伊勢 一郎, 上野 知尭, 市川 英孝, 渡辺 和宏, 神山 篤史, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　161-161　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1070. 肥満症専門医・生活習慣病改善指導士は高度肥満症とどう向き合うべきか? 高度肥満症に対する外科治療の有効性と問題点 Peer-reviewed

    内藤 剛, 田中 直樹, 井本 博文, 海野 倫明

    肥満研究　25　(Suppl.)　174-174　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1071. 腹腔鏡下スリーブ状胃切除術後の通過障害に対する治療戦略 Peer-reviewed

    井本 博文, 田中 直樹, 梶原 大輝, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　273-273　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1072. 十二指腸空腸バイパス術後の胆膵路における胆汁酸吸収機序の解明 Peer-reviewed

    上野 知尭, 田中 直樹, 井本 博文, 前川 正充, 市川 英孝, 小野 翼, 神山 篤史, 渡辺 和宏, 元井 冬彦, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　299-299　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1073. 1型糖尿病合併病的肥満症患者に対して腹腔鏡下スリーブ状胃切除術を施行した1例 Peer-reviewed

    市川 英孝, 井本 博文, 田中 直樹, 上野 知尭, 小野 翼, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    肥満研究　25　(Suppl.)　317-317　2019/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1074. 症候性上腸間膜動脈解離症例の検討 Peer-reviewed

    菅原 宏文, 後藤 均, 赤松 大二朗, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 小笠原 紀信, 高橋 宏和, 海野 倫明, 亀井 尚

    脈管学　59　(Suppl.)　S190-S190　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  1075. 総大腿動脈(CFA)病変に対する、血栓内膜摘除術の手術成績の検討 Peer-reviewed

    小笠原 紀信, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 高橋 宏和, 内藤 剛, 海野 倫明, 石田 孝宣, 亀井 尚

    脈管学　59　(Suppl.)　S238-S239　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  1076. 進行腎細胞癌による下肢動脈腫瘍塞栓の一例 Peer-reviewed

    鈴木 峻也, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 堀井 晋一良, 小笠原 紀信, 高橋 宏和, 亀井 尚, 海野 倫明, 石田 孝宣, 内藤 剛

    脈管学　59　(Suppl.)　S277-S277　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  1077. エキノコッカス症による多発腹腔内包虫嚢胞の1例 Peer-reviewed

    西牧 宏泰, 中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　80　(増刊)　868-868　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1078. Induction of Metastasis by Low-dose Gemcitabine in a Pancreatic Cancer Orthotopic Mouse Model: An Opposite Effect of Chemotherapy. International-journal Peer-reviewed

    Norihiko Sugisawa, Kentaro Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Jun Ho Park, Kei Kawaguchi, Sant P Chawla, Michael Bouvet, Shree Ram Singh, Michiaki Unno, Robert M Hoffman

    Anticancer research　39　(10)　5339-5344　2019/10

    DOI： 10.21873/anticanres.13726 　

    More details Close

    BACKGROUND/AIM: Gemcitabine is standard first-line treatment for patients with advanced pancreatic cancer, however the efficacy is limited. Although acquired drug resistance and side-effects are known to limit efficacy, opposite effects of a drug, which enhance the malignancy of treated cancer, have been observed but are not well understood. The aim of the present study was to determine whether gemcitabine has such opposite effects on the BxPC-3 human pancreatic cancer cell line expressing green fluorescent protein (BxPC-3-GFP) in an orthotopic mouse model. MATERIALS AND METHODS: BxPC-3-GFP tumors grown subcutaneously in nude mice were harvested. Tumor fragments were orthotopically implanted in the tail of the pancreas of nude mice using the technique of surgical orthotopic implantation. The BxPC-3-GFP orthotopic models were divided randomly into three groups: Group 1: untreated control; Group 2: low-dose gemcitabine (weekly intraperitoneal injection at 25 mg/kg for 6 weeks); Group 3: high-dose gemcitabine (weekly intraperitoneal injection at 125 mg/kg for 6 weeks). Each group comprised eight mice. Tumor size, fluorescent area of metastases, and body weight were measured. RESULTS: Low- and high-dose gemcitabine inhibited primary tumor growth in a dose-dependent manner, and to the greatest extent by high-dose gemcitabine compared to the untreated control (p=0.0134). In contrast, the extent of metastasis on the peritoneum was significantly increased by low-dose gemcitabine compared to the untreated control (p=0.0112). The extent of metastasis showed no significant difference between the untreated control and mice treated with high-dose gemcitabine. Body weight of the treated mice was not significantly different from that of the untreated mice. CONCLUSION: The use of very bright GFP expressing of BxPC-3 cells and the orthotopic model demonstrated an unexpected increase in metastasis by low-dose gemcitabine. Future experiments will investigate the mechanism of this phenomenon.

  1079. 【肝胆膵の救急疾患とその最新の治療現場】古典的な肝胆膵での救急疾患とその最新治療 上腸間膜動脈閉塞・解離に対するアプローチ Peer-reviewed

    菅原 宏文, 後藤 均, 赤松 大二朗, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 海野 倫明, 亀井 尚

    肝・胆・膵　79　(4)　651-658　2019/10

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1080. 【肝胆膵の救急疾患とその最新の治療現場】古典的な肝胆膵での救急疾患とその最新治療 上腸間膜動脈閉塞・解離に対するアプローチ

    菅原 宏文, 後藤 均, 赤松 大二朗, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 海野 倫明, 亀井 尚

    肝・胆・膵　79　(4)　651-658　2019/10

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1081. Intraoperative modulation of arterial blood flow in a hybrid operating room: A report of three cases. International-journal Peer-reviewed

    Yoshikatsu Saitoh, Yasuyuki Hara, Shigehito Miyagi, Chikashi Nakanishi, Wataru Nakanishi, Ryuichi Nishimura, Daijirou Akamatsu, Hitoshi Goto, Michiaki Unno, Takashi Kamei

    Clinical case reports　7　(10)　1839-1843　2019/10

    DOI： 10.1002/ccr3.2355 　

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    The preoperative modulation of arterial blood flow is widely performed to prevent massive intraoperative hemorrhage and unstable circulatory dynamics; however, this may cause complications. The intraoperative modulation of arterial blood flow can be performed with operation to reduce the physical and psychological stresses on the patients and improve intraoperative safety.

  1082. Cancer-associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer. International-journal Peer-reviewed

    Takashi Aizawa, Hideaki Karasawa, Ryo Funayama, Matsuyuki Shirota, Takashi Suzuki, Shimpei Maeda, Hideyuki Suzuki, Akihiro Yamamura, Takeshi Naitoh, Keiko Nakayama, Michiaki Unno

    Cancer medicine　8　(14)　6370-6382　2019/10

    DOI： 10.1002/cam4.2523 　

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    Recent studies have shown that the tumor microenvironment plays a significant role in the progression of solid tumors. As an abundant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs) have been shown to promote tumorigenesis and cancer aggressiveness, but their molecular characteristics remain poorly understood. In the present study, paired CAFs and normal fibroblasts (NFs) were isolated from five colorectal cancer (CRC) tissues from patients who underwent surgical resection. The gene expression profiles of CAFs and NFs identified by RNA sequencing were compared to understand the complex role of CAFs in cancer progression. Gene Set Enrichment Analysis revealed that the gene sets related to the Wnt signaling pathway were highly enriched in CAFs, as well as TGFβ signaling, which is considered to be a regulator of CAFs. Among the components of this pathway, Wnt2 was specifically expressed. The observations led us to speculate that Wnt2 is extremely involved in regulating CRC progression by CAFs. Thus, we performed immunohistochemical analysis on Wnt2 in 171 patients who underwent surgery for colorectal adenocarcinoma. Positive staining for Wnt2 was mainly observed in cancer stroma, although the immunoreactivity was weak in cancer cells. Wnt2 expression in CAFs was significantly correlated with depth of tumor (P < .001), lymph node metastasis (P = .044), TNM stage (P = .010), venous invasion (P < .001), and recurrence (P = .013). Subsequent in vitro analyses were conducted using conditioned medium (CM) from immortalized CAFs transfected with siRNA targeting Wnt2. As a result, cancer cell invasion and migration were significantly decreased in the CM from immortalized CAFs transfected with siRNA targeting Wnt2. Our findings indicated that Wnt2 protein released from CAFs enhances CRC cell invasion and migration. In conclusion, Wnt2 secreted by CAFs plays a key role in cancer progression and is a potential therapeutic target for CRC.

  1083. Evaluation of the impact of psoas muscle index, a parameter of sarcopenia, in patients with esophageal squamous cell carcinoma receiving neoadjuvant therapy. Peer-reviewed

    Yohei Ozawa, Toru Nakano, Yusuke Taniyama, Tadashi Sakurai, Yu Onodera, Kurodo Kamiya, Makoto Hikage, Chiaki Sato, Kai Takaya, Takuro Konno, Michiaki Unno, Takashi Kamei

    Esophagus : official journal of the Japan Esophageal Society　16　(4)　345-351　2019/10

    DOI： 10.1007/s10388-019-00670-3 　

    ISSN： 1612-9059

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    BACKGROUND: The impact of sarcopenia on digestive cancer is widely known. Muscle mass, defined as the psoas muscle index (PMI), is an important parameter of sarcopenia. However, the relationship between esophageal cancer and PMI has not been fully investigated, especially in patients receiving neoadjuvant therapy. METHODS: To elucidate the influence of the PMI on patients with esophageal squamous cell carcinoma receiving neoadjuvant therapy, the progression of sarcopenia defined by the PMI, the relationship between pretherapeutic/preoperative sarcopenia and patient characteristics, and patient survival were retrospectively investigated in 82 patients with esophageal squamous cell carcinoma who underwent neoadjuvant therapy. RESULTS: The PMI decreased by more than 20 mm2/m2 between the pretherapeutic and preoperative periods in 75.6% of the patients. Pretherapeutic sarcopenia (low PMI) correlated with the pathological therapeutic response, postoperative recurrence, and pretherapeutic body mass index. Neoadjuvant chemoradiotherapy was associated with the progression of sarcopenia. The pretherapeutic sarcopenia group (low PMI) had worse disease-free survival (DFS) than the non-sarcopenia group. Furthermore, pretherapeutic sarcopenia (low PMI) was an independent prognostic risk factor of DFS according to univariate and multivariate analyses. CONCLUSIONS: The PMI may decrease during neoadjuvant therapy, especially during neoadjuvant chemoradiotherapy. Pretherapeutic sarcopenic (low PMI) patients should be followed-up more carefully postoperatively because higher risks of recurrence and poorer rates of disease-free survival are associated with these patients.

  1084. Long-Term Outcomes of Acute Limb Ischemia: A Retrospective Analysis of 93 Consecutive Limbs. Peer-reviewed

    Michihisa Umetsu, Daijirou Akamatsu, Hitoshi Goto, Masato Ohara, Munetaka Hashimoto, Takuya Shimizu, Hirofumi Sugawara, Ken Tsuchida, Yoshitaro Yoshida, Yuta Tajima, Shunya Suzuki, Shinichiro Horii, Tetsuo Watanabe, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Annals of vascular diseases　12　(3)　347-353　2019/09/25

    DOI： 10.3400/avd.oa.19-00018 　

    ISSN： 1881-641X

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    Objective: To examine the medium- to long-term outcomes of acute limb ischemia (ALI), which are unclear at present. Methods: We analyzed 93 consecutive limbs in 77 patients with ALI between January 2005 and December 2015 treated at our vascular center. We categorized the cases into four groups according to etiology (embolism, thrombosis, graft thrombosis, and dissection groups) to assess survival, limb salvage, and freedom from re-intervention rates. Results: The mean age at onset was 72±15 years. The median follow-up length was 2.90 years. The Rutherford categories I, IIa, IIb, and III included 1, 38, 51, and 3 cases, respectively. Thromboembolectomy was performed in all patients in the embolism and thrombosis groups. In addition, endovascular treatment was performed in 25 (37.3%) patients, especially in the thrombosis group (81.3%). A major amputation could not be avoided in 10 patients. The 5-year limb salvage rates for categories IIa and IIb were 97.1% and 83.1%, respectively. The 5-year freedom from re-intervention rate was 89.2%. The survival rates at 1, 3, and 5 years were 87.9%, 75.2%, and 60.6%, respectively. Conclusion: The 5-year survival rates of patients with ALI were equivalent to those with chronic limb threatening ischemia (CLTI). The intervention and long-term outcomes were distinguishable according to etiology.

  1085. The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model. International-journal Peer-reviewed

    Keigo Kanehara, Shinobu Ohnuma, Yoshitake Kanazawa, Keisuke Sato, Shoji Kokubo, Hideyuki Suzuki, Hideaki Karasawa, Takehiro Suzuki, Chitose Suzuki, Takeshi Naitoh, Michiaki Unno, Takaaki Abe

    Scientific reports　9　(1)　12739-12739　2019/09/04

    DOI： 10.1038/s41598-019-48974-9 　

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    In inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a common clinical complication that is promoted by transforming growth factor β1 (TGF-β1). In our previous study, MA-35 attenuated renal fibrosis by inhibiting both TNF-α and TGF-β1 signaling. This study aimed to identify the possible antitumor effects and antifibrotic effects of MA-35 using an AOM/DSS mouse model. MA-35 was orally administered every day for 70 days in the AOM/DSS mouse model. There was no difference in weight loss between the AOM/DSS group and the AOMDSS + MA-35 group, but the disease activity index score and the survival rate were improved by MA-35. MA-35 blocked the anemia and shortening of the colon induced by AOM/DSS. MA-35 reduced the macroscopic formation of tumors in the colon. In the microscopic evaluation, MA-35 reduced inflammation and fibrosis in areas with dysplasia. Furthermore, the TNF-α mRNA level in the colon tended to be reduced, and the interleukin 6, TGF-β1 and fibronectin 1 mRNA levels in the colon were significantly reduced by MA-35. These results suggested that MA-35 inhibited AOM/DSS-induced carcinogenesis by reducing inflammation and fibrosis.

  1086. 多剤耐性ABCG2の新規抑制剤の同定(Identifying new inhibitors of multidrug resistance linked ABC transporter, ABCG2)

    小久保 翔志, 大沼 忍, 唐澤 秀明, 山村 明寛, 村上 恵, 杉沢 徳彦, 石田 孝宣, 亀井 尚, 海野 倫明

    日本癌学会総会記事　78回　P-3355　2019/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  1087. 膵臓手術後における膵外分泌機能と栄養状態に関する検討

    石田 晶玄, 元井 冬彦, 佐藤 英昭, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 大沼 忍, 水間 正道, 中川 圭, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　299-299　2019/09

    Publisher: (一社)日本臨床栄養代謝学会

    eISSN： 2434-4966

  1088. 晩期合併症・トランジション 先天性胆道拡張症術後肝内結石に対する治療

    大塚 英郎, 畠 達夫, 青木 修一, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　42　33-33　2019/09

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  1089. 切除企図膵癌の微小転移診断における血中KRAS変異DNA測定の有用性(Cell-free KRAS mutant allele predicts the micrometastasis in pancreatic cancer patients with curative-intent resection)

    畠 達夫, 水間 正道, 元井 冬彦, 高舘 達之, 有明 恭平, 青木 修一, 川口 桂, 大塚 英郎, 林 洋毅, 大沼 忍, 海野 倫明

    日本癌学会総会記事　78回　P-1128　2019/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1090. MET/CTGF signal阻害は膵癌細胞の肝臓への生着・転移を抑制する(MET/CTGF axis induces cell clustering and confers chemotherapy resistance in micrometastases of pancreatic cancer)

    青木 修一, 松居 彩, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 水間 正道, 大塚 英郎, 林 洋毅, 大沼 忍, 元井 冬彦, 海野 倫明

    日本癌学会総会記事　78回　P-2047　2019/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1091. 【知っておきたい特殊な食道腫瘍・腫瘍様病変】食道に発生したverrucous carcinoma

    佐藤 千晃, 谷山 裕亮, 櫻井 直, 日景 允, 高屋 快, 岡本 宏史, 今野 卓朗, 氏家 直人, 小関 健, 安藤 涼平, 藤島 史喜, 内藤 剛, 海野 倫明, 亀井 尚

    胃と腸　54　(10)　1439-1441　2019/09

    Publisher: (株)医学書院

    ISSN： 0536-2180

    eISSN： 1882-1219

  1092. 精神疾患を有する悪性高熱症例への対応に関する考察 Peer-reviewed

    福山 尚治, 矢崎 伸樹, 椎葉 健一, 吾妻 俊弘, 武者 宏昭, 海野 倫明

    Progress in Medicine　39　(9)　937-941　2019/09

    Publisher: (株)ライフ・サイエンス

    ISSN： 0287-3648

  1093. 女性外科医のロールモデル 全国大学医学部における卒前のキャリア教育による早期啓発講義の調査報告 Peer-reviewed

    佐藤 章子, 多田 寛, 宮下 穣, 原田 成美, 濱中 洋平, 藤井 里圭, 福與 なおみ, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会雑誌　120　(5)　564-566　2019/09

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1094. 高齢者に対する炎症性腸疾患の治療 高齢者潰瘍性大腸炎の外科治療の特徴と治療成績 Peer-reviewed

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(9)　A53-A53　2019/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  1095. 専門領域の連携による炎症性腸疾患の治療 クローン病の腸管不全例の予防/治療における専門領域での連携 Peer-reviewed

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(9)　A56-A56　2019/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  1096. 直腸癌局所再発に対する手術療法の現状と問題点 Peer-reviewed

    大沼 忍, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(9)　A143-A143　2019/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  1097. メチオニンを標的とした新規膵癌栄養療法戦略の開発 Peer-reviewed

    川口 桂, 畠 達夫, 伊関 雅裕, 石田 晶玄, 水間 正道, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, Hoffman Robert, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　92-92　2019/09

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1098. 膵全摘術後の脂肪肝発症の危険因子についての検討 Peer-reviewed

    畠 達夫, 水間 正道, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　300-300　2019/09

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1099. 膵癌根治切除例の周術期栄養状態に年齢の及ぼす影響 Peer-reviewed

    元井 冬彦, 伊関 雅裕, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 中川 圭, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　310-310　2019/09

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1100. 膵頭十二指腸切除術周術期における血清亜鉛値についての検討 Peer-reviewed

    伊関 雅裕, 水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　311-311　2019/09

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1101. 慢性膵炎手術の至適時期を栄養面から考える Peer-reviewed

    佐藤 英昭, 石田 晶玄, 元井 冬彦, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 亀井 尚, 内藤 剛, 海野 倫明

    学会誌JSPEN　1　(Suppl.)　460-460　2019/09

    Publisher: (一社)日本静脈経腸栄養学会

    eISSN： 2434-4966

  1102. 血液型不適合肝臓移植の現状と課題 心停止ドナー肝グラフトの臓器再生の現状と展望 Peer-reviewed

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　184-184　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1103. 肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例 Peer-reviewed

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 宮崎 勇希, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 大田 英揮, 高瀬 圭, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　200-200　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1104. 補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響 Peer-reviewed

    戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　54　(総会臨時)　226-226　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1105. エコー上指摘された生体肝移植後早期門脈ガス像の臨床的意義 Peer-reviewed

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 内藤 剛, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　54　(総会臨時)　290-290　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1106. 女性外科医のロールモデル 全国大学医学部における卒前のキャリア教育による早期啓発講義の調査報告

    佐藤 章子, 多田 寛, 宮下 穣, 原田 成美, 濱中 洋平, 藤井 里圭, 福與 なおみ, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会雑誌　120　(5)　564-566　2019/09

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1107. Current status of site-specific cancer registry system for the clinical researches: aiming for future contribution by the assessment of present medical care. Peer-reviewed

    Koichi Hirata, Masafumi Imamura, Toshiyoshi Fujiwara, Tsuguya Fukui, Toshiharu Furukawa, Mitsukazu Gotoh, Kenichi Hakamada, Megumi Ishiguro, Yoshihiro Kakeji, Hiroyuki Konno, Hiroaki Miyata, Masaki Mori, Kenji Okita, Masami Sato, Akiko Shibata, Ichiro Takemasa, Michiaki Unno, Kohei Yokoi, Toshihiko Nishidate, Masahiko Nishiyama

    International journal of clinical oncology　24　(9)　1161-1168　2019/09

    DOI： 10.1007/s10147-019-01434-w 　

    ISSN： 1341-9625

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    BACKGROUND: The current status of site-specific cancer registry has not been elucidated, but sufficient system is found in some societies. The purpose of this study was to clear the present condition of site-specific cancer registries in Japan and to suggest for the improvement. METHODS: The questionnaire was conducted by the study group of the Ministry of Health, Labor, and Welfare. It consisted of 38 questions, conflicts of interest, clinical research method, informed consent and funding for registry. We distributed this questionnaire to 28 academic societies, which had published the clinical practice guideline(s) assessed under Medical Information Network Distribution Service (MINDS). RESULTS: The concept of the importance in assessment for medical quality by the data of the site-specific cancer registry was in good consensus. But the number of the society with the mature registry was limited. The whole-year registry with the scientific researches in the National Clinical Database (NCD) and in the Translational Research Informatics Center (TRI) might seem to be in success, because assured enhancement may be estimated. Now, academic societies have the structural factors, i.e., the financial limitation in the registry maintenance and the data analysis, and in the difficulty of employment of the researchers with skill and talent. CONCLUSIONS: To manage the site-specific cancer registry effectively, the scientific registry system will be essentially important. Each academic society had much experienced highly qualified clinical researches in past. Accordingly, the scientific suggestion and co-operation should be of great importance for the improvement.

  1108. 腹腔鏡下幽門側胃切除における予後規定因子の検討

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　P56-7　2019/07

    Publisher: (一社)日本消化器外科学会

  1109. 進行消化管癌は癌関連DICを引き起こすか

    山村 明寛, 武者 宏昭, 大沼 忍, 田中 直樹, 渡辺 和宏, 青木 豪, 神山 篤史, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P276-1　2019/07

    Publisher: (一社)日本消化器外科学会

  1110. 当科における腹壁瘢痕ヘルニアに対する治療戦略

    青木 豪, 井本 博文, 山村 明寛, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P262-2　2019/07

    Publisher: (一社)日本消化器外科学会

  1111. 減量手術における術前減量の効果の検討

    田中 直樹, 井本 博文, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　74回　P41-4　2019/07

    Publisher: (一社)日本消化器外科学会

  1112. 当院における病的肥満症に対する減量手術の治療成績と治療戦略

    井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　74回　O52-3　2019/07

    Publisher: (一社)日本消化器外科学会

  1113. 高度侵襲術後急性期の栄養管理 膵癌周術期における血清亜鉛値の意義

    伊関 雅裕, 水間 正道, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　WS15-6　2019/07

    Publisher: (一社)日本消化器外科学会

  1114. 当科における残膵全摘術の短期・長期治療成績の検討

    海野 裕一郎, 伊関 雅裕, 高館 達之, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P225-6　2019/07

    Publisher: (一社)日本消化器外科学会

  1115. 膵癌に対する膵切除後、門脈圧亢進症による異所性静脈瘤の検討

    遠山 慎吾, 伊関 雅裕, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P231-2　2019/07

    Publisher: (一社)日本消化器外科学会

  1116. 臨床外科医ができる動物移植モデルを使った基礎研究

    山田 修平, 柿崎 裕太, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　RS36-6　2019/07

    Publisher: (一社)日本消化器外科学会

  1117. 短期間で形態変化を認めた膵腺房細胞癌の1例

    池田 未緒, 三浦 晋, 佐野 貴紀, 田中 裕, 松本 諒太郎, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 菊田 和宏, 濱田 晋, 粂 潔, 菅野 敦, 畠 達夫, 元井 冬彦, 海野 倫明, 大森 優子, 古川 徹, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　207回　50-50　2019/07

    Publisher: 日本消化器病学会-東北支部

  1118. 治療により運動機能改善をHigh Resolution Manometryにて認めた好酸球性食道炎の1例

    佐藤 千晃, 安藤 涼平, 氏家 直人, 岡本 宏史, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　207回　48-48　2019/07

    Publisher: 日本消化器病学会-東北支部

  1119. 出血させない安全・簡便な気管分岐下リンパ節郭清のコツ

    谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 岡本 宏史, 高屋 快, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　RS2-4　2019/07

    Publisher: (一社)日本消化器外科学会

  1120. 予後予測因子としてのCONUT scoreとリンパ球好中球比(NLR)について

    今野 卓朗, 櫻井 直, 谷山 裕亮, 日景 允, 佐藤 千晃, 岡本 宏史, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P5-3　2019/07

    Publisher: (一社)日本消化器外科学会

  1121. 【食道】高度食道裂孔ヘルニアに対する内視鏡外科手術の工夫 食道運動機能とTension freeを意識した腹腔鏡下食道裂孔ヘルニア修復術

    佐藤 千晃, 谷山 裕亮, 櫻井 直, 日景 允, 岡本 宏史, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS5-3　2019/07

    Publisher: (一社)日本消化器外科学会

  1122. 発生部位別にみた咽頭食道憩室の臨床的特徴および治療方針についての検討

    氏家 直人, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 岡本 宏史, 今野 卓朗, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P10-1　2019/07

    Publisher: (一社)日本消化器外科学会

  1123. 高度侵襲術後急性期の栄養管理 cStage II/III食道癌患者における周術期の栄養指標変化と予後予測

    日景 允, 櫻井 直, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS15-1　2019/07

    Publisher: (一社)日本消化器外科学会

  1124. 当科における頸部食道癌の治療成績の検討

    岡本 宏史, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 高屋 快, 今野 卓朗, 氏家 直人, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　O28-6　2019/07

    Publisher: (一社)日本消化器外科学会

  1125. Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial). International-journal Peer-reviewed

    Eiji Oki, Yasunori Emi, Takeharu Yamanaka, Hiroyuki Uetake, Kei Muro, Takao Takahashi, Takeshi Nagasaka, Etsuro Hatano, Hitoshi Ojima, Dai Manaka, Tetsuya Kusumoto, Yu Katayose, Toshiyoshi Fujiwara, Kazuhiro Yoshida, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Kenichi Sugihara, Yoshihiko Maehara

    British journal of cancer　121　(3)　222-229　2019/07

    DOI： 10.1038/s41416-019-0518-2 　

    More details Close

    BACKGROUND: Chemotherapy with biologics followed by liver surgery improves the resection rate and survival of patients with colorectal liver metastasis (CRLM). However, no prospective study has compared the outcomes of chemotherapy with bevacizumab (BEV) versus cetuximab (CET). METHODS: The ATOM study is the first randomised trial comparing BEV and CET for initially unresectable CRLM. Patients were randomly assigned in a 1:1 ratio to receive mFOLFOX6 plus either BEV or CET. The primary endpoint was progression-free survival (PFS). RESULTS: Between May 2013 and April 2016, 122 patients were enrolled. Median PFS was 11.5 months (95% CI 9.2-13.3 months) in the BEV group and 14.8 months (95% CI 9.7-17.3 months) in the CET group (hazard ratio 0.803; P = 0.33). Patients with a smaller-number but larger-sized metastases did better in the CET group. In the BEV and CET groups, the response rates were 68.4% and 84.7% and the resection rates were 56.1% and 49.2%, respectively. CONCLUSION: Although CET achieved a better response rate than BEV for patients with a small number of large liver metastases, both biologics had similar efficacy regarding liver resection and acceptable safety profiles. To achieve optimal PFS, biologics should be selected in accordance with patient conditions. TRIAL REGISTRATION: This trial is registered at ClinicalTrials.gov (number NCT01836653), and UMIN Clinical Trials Registry (UMIN-CTR number UMIN000010209).

  1126. 肝切除における術中出血が与える影響の栄養学的パラメータを用いた解析 Peer-reviewed

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P193-2　2019/07

    Publisher: (一社)日本消化器外科学会

  1127. 高度心機能低下を有するWilson病患者に対し、肝移植後、大動脈内バルーンパンピングを使用し救命した一例 Peer-reviewed

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P195-4　2019/07

    Publisher: (一社)日本消化器外科学会

  1128. 腎機能障害を有する患者の周術期管理 Chronic kidney diseaseを伴う肝細胞癌患者に対する肝切除術 周術期合併症への影響 Peer-reviewed

    西村 隆一, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS16-7　2019/07

    Publisher: (一社)日本消化器外科学会

  1129. 小児生体肝移植術後の晩期門脈合併症に対する治療戦略 Peer-reviewed

    藤尾 淳, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P198-6　2019/07

    Publisher: (一社)日本消化器外科学会

  1130. 胆道閉鎖症葛西術後キャリーオーバー症例を含む、複数開腹歴のある症例に対する肝移植 Peer-reviewed

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 佐々木 健吾, 柿崎 裕太, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　O22-2　2019/07

    Publisher: (一社)日本消化器外科学会

  1131. The effect of anti-TNF-alpha Ab in AOM/DSS-induced colitic cancer mouse model Peer-reviewed

    Ohnuma S, Wang DY, Suzuki H, Kanehara K, Karasawa H, Kohyama A, Watanabe K, Miura K, Kamei T, Naitoh T, Unno M

    Cancer Research　79　(13)　2019/07

  1132. dentifying new inhibitors of ABCG2 by high-throughput screening Peer-reviewed

    Kokubo S, Ohnuma S, Karasawa H, Yamamura A, Suzuki H, Murakami M, Sugisawa N, Kanehara K, Sato K, Ishida T, Kamei T, Naitoh T, Unno M

    Cancer Research　79　(13)　2019/07

  1133. 【腹腔鏡下肝胆膵手術の新時代-ラパロからロボティクスへ-】胆道 胆道悪性疾患における腹腔鏡下手術

    中川 圭, 益田 邦洋, 大塚 英郎, 高舘 達之, 石田 晶玄, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    肝・胆・膵　79　(1)　89-97　2019/07

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1134. Metastasis of ovarian cancer to the bile duct: a case report. International-journal Peer-reviewed

    Masahiro Shijo, Koji Fukase, Hideo Ohtsuka, Kyohei Ariake, Kunihiro Masuda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Surgical case reports　5　(1)　100-100　2019/06/20

    DOI： 10.1186/s40792-019-0659-9 　

    More details Close

    BACKGROUND: Ovarian cancer typically spreads along the peritoneum or metastasizes through the blood or lymphatic stream. The bile duct is an extremely rare site of ovarian cancer-associated metastases. CASE PRESENTATION: A 55-year-old female underwent surgery for advanced left ovarian cancer 2 years ago. She was diagnosed with ovarian serous adenocarcinoma with multiple peritoneal metastases. She received chemotherapy for the residual peritoneal metastases. She achieved a clinical complete response and was followed up with imaging examinations for 1 year. She then complained of dark urine, yellowish discoloration of the eyes, and weight loss. Computed tomography showed an approximately 10-mm solid tumor at the hepatic hilum. Simultaneously, multiple peritoneal metastases were detected in the abdominal and pelvic cavity. Intraductal ultrasonography suggested that the hepatic hilum tumor was located in the bile duct wall. Tumor biopsy and brush cytology of the bile duct indicated atypical cells suspicious for carcinoma. After percutaneous transhepatic portal embolization, she underwent right hepatectomy and extrahepatic bile duct resection for the hepato-hilar tumor. The histopathological features were dysplastic cells with hyperchromatic nuclei and no dysplastic cells in the native biliary epithelium. Immunohistochemical staining revealed that the tumor cells were positive for CK-7 and WT-1 and negative for CK-20 and ER. These results suggested that the tumor was a metastasis of the ovarian serous adenocarcinoma. CONCLUSION: This may be the first case of ovarian cancer metastasis to the bile duct. While it is extremely rare, ovarian cancer may metastasize to the hepatic duct, mimicking hilar cholangiocarcinoma.

  1135. Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery

    Yuichi Nagakawa, Yatsuka Sahara, Yuichi Hosokawa, Yoshiaki Murakami, Hiroki Yamaue, Sohei Satoi, Michiaki Unno, Shuji Isaji, Itaru Endo, Masayuki Sho, Tsutomu Fujii, Chie Takishita, Yosuke Hijikata, Shuji Suzuki, Shigeyuki Kawachi, Kenji Katsumata, Tetsuo Ohta, Takukazu Nagakawa, Akihiko Tsuchida

    Annals of Surgical Oncology　26　(6)　1629-1636　2019/06/15

    Publisher: Springer New York LLC

    DOI： 10.1245/s10434-018-07131-8 　

    ISSN： 1534-4681 1068-9265

  1136. 慢性膵炎の戦略 手術成績からみた慢性膵炎手術時期の検討

    石田 晶玄, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 青木 豪, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    膵臓　34　(3)　A60-A61　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1137. 切除不能局所進行膵癌:化学療法と化学放射線療法 切除不能局所進行膵癌に対する最近の治療戦略の成績

    林 洋毅, 畠 達夫, 伊関 雅裕, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 元井 冬彦, 海野 倫明

    膵臓　34　(3)　A75-A76　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1138. 家族性膵癌のマネージメント 家族性膵癌家系に発生した膵癌症例の切除成績 再発例の治療戦略についての検討

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    膵臓　34　(3)　A98-A99　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1139. 膵神経内分泌腫瘍の切除適応と切除範囲 膵神経内分泌腫瘍に対する外科治療戦略 当科症例の後方視的検討から

    森川 孝則, 青木 豪, 水間 正道, 畠 達夫, 伊関 雅裕, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    膵臓　34　(3)　A121-A121　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1140. ミトコンドリア蛋白であるStomatin like protein2がもたらす膵癌転移メカニズムの解明

    有明 恭平, 党 超, 大塚 英郎, 石田 晶玄, 益田 邦洋, 元井 冬彦, 森川 孝則, 中川 圭, 水間 正道, 川口 桂, 高舘 達之, 伊関 雅裕, 畠 達夫, 内藤 剛, 亀井 尚, 海野 倫明

    膵臓　34　(3)　A220-A220　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1141. 審査腹腔鏡を用いた膵癌の新たな治療戦略

    高舘 達之, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    膵臓　34　(3)　A229-A229　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1142. 膵癌術前治療後のγStageに関する検討

    水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    膵臓　34　(3)　A275-A275　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1143. 膵頭十二指腸切除周術期における亜鉛欠乏症

    伊関 雅裕, 水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 正宗 淳, 海野 倫明

    膵臓　34　(3)　A285-A285　2019/06

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1144. HGF/MET signa阻害は肝臓への膵癌細胞のcolonizationを抑制する

    青木 修一, 井上 享悦, 元井 冬彦, 亀井 尚, 内藤 剛, Duda Dan, 海野 倫明

    膵臓　34　(3)　A224-A224　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1145. 周術期における栄養療法とその評価(1) cStage II/III食道癌患者における周術期の栄養指標変化と手術成績

    日景 允, 谷山 裕亮, 櫻井 直, 佐藤 千晃, 高屋 快, 岡本 宏史, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    外科と代謝・栄養　53　(3)　85-85　2019/06

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  1146. 腸型IPMNはどのように発生するか? CDX2、MUC2、alcian blue三重染色による検討

    大森 優子, 水上 裕輔, 元井 冬彦, 海野 倫明, 古川 徹

    膵臓　34　(3)　A169-A169　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1147. Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery. International-journal Peer-reviewed

    Yuichi Nagakawa, Yatsuka Sahara, Yuichi Hosokawa, Yoshiaki Murakami, Hiroki Yamaue, Sohei Satoi, Michiaki Unno, Shuji Isaji, Itaru Endo, Masayuki Sho, Tsutomu Fujii, Chie Takishita, Yosuke Hijikata, Shuji Suzuki, Shigeyuki Kawachi, Kenji Katsumata, Tetsuo Ohta, Takukazu Nagakawa, Akihiko Tsuchida

    Annals of surgical oncology　26　(6)　1629-1636　2019/06

    DOI： 10.1245/s10434-018-07131-8 　

    ISSN： 1068-9265

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    BACKGROUND: The efficacy of neoadjuvant therapy (NAT), including neoadjuvant chemotherapy (NAC) and neoadjuvant chemo-radiotherapy (NACRT), for patients with borderline resectable pancreatic cancer (BRPC) has not been elucidated. This study aimed to clarify the efficacy of NAC and NACRT for patients with BRPC. METHODS: The study analyzed the treatment outcomes of 884 patients treated for BRPC from 2011 to 2013. Treatment results were compared between upfront surgery and NAT and between NAC and NACRT using propensity score-matching analysis. Overall survival (OS) was calculated via intention-to-treat analyses. RESULTS: The overall resection rates for the patients who underwent NAT were significantly lower than for the patients who underwent upfront surgery (75.1% vs 93.3%; p < 0.001). However, the R0 resection rate was significantly higher for NAT than for upfront surgery (p < 0.001). Additionally, the OS for the patients who received NAT was significantly longer than for those who underwent upfront surgery (median survival time [MST], 25.7 vs 19.0 months; p = 0.015). The lymph node rate for the patients with NACRT was significantly lower than for those who underwent NAC (p < 0.001). However, the resection rate for the NACRT cases was significantly lower than for the NAC cases (p = 0.041). The local recurrence rate for the NACRT cases was significantly lower than for the NAC cases (p = 0.002). However, OS did not differ significantly between NAC and NACRT (MST, 29.2 vs 22.5 months; p = 0.130). CONCLUSIONS: The study showed that NAT has potential benefit for patients with BRPC. Compared with NAC, NACRT decreased the rates for lymph node metastasis and local recurrence but did not improve the prognosis.

  1148. Changes in Enterohepatic Circulation after Duodenal-Jejunal Bypass and Reabsorption of Bile Acids in the Bilio-Pancreatic Limb. International-journal Peer-reviewed

    Ichiro Ise, Naoki Tanaka, Hirofumi Imoto, Masamitsu Maekawa, Atsushi Kohyama, Kazuhiro Watanabe, Fuyuhiko Motoi, Michiaki Unno, Takeshi Naitoh

    Obesity surgery　29　(6)　1901-1910　2019/06

    DOI： 10.1007/s11695-019-03790-y 　

    ISSN： 0960-8923

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    BACKGROUND AND AIMS: Duodenal-jejunal bypass (DJB) shows great effects on weight loss and diabetes improvement. Previously, we reported that the bilio-pancreatic (BP) limb plays an important role in glycemic improvement and in serum bile acid (BA) level increase as reported by Miyachi et al. (Surgery 159(5):1360-71, 2016). This study aimed to investigate the mechanism of BA elevation after DJB and the relationship between these effects and BP-limb length. METHODS: Otsuka Long-Evans Tokushima Fatty rats with diabetes were randomly assigned into four groups: one sham group and three DJB groups. Three DJB groups were defined according to the BP-limb length: 0 cm, 15 cm, and 30 cm. The lengths of the alimentary limb and common channel were set equally in each DJB groups. Body weight, glucose tolerance, and BA levels in the liver, bile juice, portal vein, and intestinal contents were assessed postoperatively. Changes in enterohepatic circulation of BAs were assessed using labeled BA. RESULTS: BA elevation after DJB was higher with longer BP-limb. In the 30-cm group, the serum total BA level and BA levels in the portal vein, liver, and bile juice were greater than those in other groups. The enterohepatic circulation was shortened in the 15-cm and 30-cm groups. CONCLUSIONS: Shortening of the "enterohepatic circulation" by early reabsorption of BAs in the BP-limb, not by the early influx of bile juice into the ileum, was the main cause of BA elevation after DJB. Thus, glycemic improvement and elevation of BA concentration after DJB depend on the BP-limb length.

  1149. Acute esophageal necrosis with esophagus perforation treated by thoracoscopic subtotal esophagectomy and reconstructive surgery on a secondary esophageal stricture: a case report. International-journal Peer-reviewed

    Ryujiro Akaishi, Yusuke Taniyama, Tadashi Sakurai, Hiroshi Okamoto, Chiaki Sato, Michiaki Unno, Takashi Kamei

    Surgical case reports　5　(1)　73-73　2019/05/08

    DOI： 10.1186/s40792-019-0636-3 　

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    BACKGROUND: Acute esophageal necrosis is defined as necrosis of the esophageal mucosa causing diffuse black pigmentation of the esophagus, the so-called black esophagus from its endoscopic findings. The prevalence is only 0.001~0.2%, while its mortality rate is up to 32%. However, most of the cases are fatal by comorbidities. CASE PRESENTATION: A 67-year-old female with diabetes mellitus was transported to the emergency room with hematemesis and disordered consciousness. She had suffered from nausea and epigastralgia for 2 days. The patient's general status was shock evidenced by vital signs, and she did not respond to rehydration. After intubation, emergency endoscopic examination revealed black pigmentation of the esophageal mucosa, and the condition was diagnosed as acute esophageal necrosis. Antibiotics and plasmapheresis had been started, and the patient gradually stabilized. One week after the admission, esophagus perforation was suspected from the significant increase of the right pleural effusion and free air at the esophagus wall and the mediastinum on CT scan. Emergency thoracoscopy revealed an edematous esophagus which was colored black. Esophagectomy with esophagostomy and enterostomy was performed. On resected specimen, mucosal necrosis was found only on the squamous epithelium, with three perforating areas in the middle to lower thoracic esophagus. No signs of inflammation or ischemia were found on the gastric mucosa of the esophagogastric junction. After the operation, the patient recovered generally well, except for the severe stenosis of the cervical esophagus. Cervical esophagectomy, tracheotomy, and anterior thoracic route reconstruction with free jejunum interposition and gastric tube were performed 9 months after the first surgery. No postoperative complications occurred; on the 37th day after the operation, the patient was eating well and was transferred to continue swallowing rehabilitation. CONCLUSION: It is important to detect the esophagus perforation and mediastinitis early and thereby not to miss the chance of surgical intervention to save the patient's life. Surgery should be minimized, and reconstruction should be considered next. If the cervical esophagus is also affected, reconstruction surgery should be performed by removing cervical esophagus and anastomosing it to the hypopharynx using a gastric tube and free jejunum interposition as needed.

  1150. Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review. International-journal Peer-reviewed

    Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Takashi Murakami, Michiaki Unno, Robert M Hoffman

    Cells　8　(5)　2019/05/02

    DOI： 10.3390/cells8050410 　

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    An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G2 phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective.

  1151. 腫瘍出血による大量下血に対して緊急手術を施行した食道癌小腸転移の1例

    三田地 克昂, 有明 恭平, 藤島 史喜, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　39　(4)　733-737　2019/05

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1152. IgG4関連硬化性胆管炎診療ガイドライン Peer-reviewed

    神澤 輝実, 中沢 貴宏, 田妻 進, 全 陽, 田中 篤, 大原 弘隆, 村木 崇, 乾 和郎, 井上 大, 西野 隆義, 内藤 格, 糸井 隆夫, 能登原 憲司, 菅野 敦, 窪田 賢輔, 平野 賢二, 伊佐山 浩通, 清水 京子, 露口 利夫, 下瀬川 徹, 千葉 勉, 岡崎 和一, 滝川 一, 木村 理, 海野 倫明, 吉田 雅博, 川 茂幸, 日本胆道学会, 作成委員会, Delphi法による専門家委員会, 評価委員会, 厚生労働省難治性疾患等克服研究事業「IgG4関連疾患の診断基準ならびに治療指針の確立を目指す研究班」, 厚生労働省難治性疾患等克服研究事業「難治性の肝・胆道疾患に関する研究調査班」

    胆道　33　(2)　169-210　2019/05

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1153. 【肝門部領域胆管癌:残された問題をどう解決すべきか?】高齢者(80歳以上)の耐術能はどのように評価すべきか?

    益田 邦洋, 中川 圭, 元井 冬彦, 海野 倫明

    胆と膵　40　(5)　373-377　2019/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1154. 【術中・術後合併症を起こさないコツ】結腸癌手術 Peer-reviewed

    唐澤 秀明, 大沼 忍, 海野 倫明, 内藤 剛

    消化器外科　42　(6)　935-943　2019/05

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  1155. A Simple and Useful Predictive Assay for Evaluating the Quality of Isolated Hepatocytes for Hepatocyte Transplantation. International-journal Peer-reviewed

    Muneyuki Matsumura, Takehiro Imura, Akiko Inagaki, Hiroyuki Ogasawara, Kengo Fukuoka, Ibrahim Fathi, Shigehito Miyagi, Kazuo Ohashi, Michiaki Unno, Takashi Kamei, Susumu Satomi, Masafumi Goto

    Scientific reports　9　(1)　6166-6166　2019/04/16

    DOI： 10.1038/s41598-019-42720-x 　

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    No optimal assay for assessing isolated hepatocytes before hepatocyte transplantation (HTx) has been established, therefore reliable and rapid assays are warranted. Isolated rat hepatocytes were dipped in a water bath (necrosis model), and were also cultured with Okadaic acid (apoptosis model) or vehicle, followed by cellular assessment including trypan blue exclusion (TBE) viability, ADP /ATP ratio, plating efficiency (PE), DNA quantity and ammonia elimination. Hepatocytes were transplanted into the liver of analbuminemic rats, subsequently engraftment was assessed by serum albumin and the histology of transplanted grafts. In the necrosis model, the ADP/ATP ratio was strongly and negatively correlated with the TBE (R2 = 0.559, P < 0.001). In the apoptosis model, the ADP/ATP ratio assay, PE, DNA quantification and an ammonia elimination test clearly distinguished the groups (P < 0.001, respectively). The ADP/ATP ratio, PE and DNA quantity were well-correlated and the ammonia elimination was slightly correlated with the transplant outcome. TBE could not distinguish the groups and was not correlated with the outcome. The ADP/ATP ratio assay predicted the transplant outcome. PE and DNA quantification may improve the accuracy of the retrospective (evaluations require several days) quality assessment of hepatocytes. The ADP/ATP ratio assay, alone or with a short-term metabolic assay could improve the efficiency of HTx.

  1156. Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis. International-journal Peer-reviewed

    Tsutomu Takenami, Shimpei Maeda, Hideaki Karasawa, Takashi Suzuki, Toru Furukawa, Takanori Morikawa, Tatsuyuki Takadate, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    BMC cancer　19　(1)　318-318　2019/04/05

    DOI： 10.1186/s12885-019-5548-x 　

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    BACKGROUND: The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, because the distinction has important implications for the treatment of these malignancies. However, there are no biomarkers for the differential diagnosis of PHC and DCC. The present study aimed to identify novel diagnostic immunohistochemical biomarkers to distinguish PHC from DCC. METHODS: Liquid chromatography tandem mass spectrometry (LC-MS/MS) was employed to detect candidate proteins. Ten PHC and 8 DCC specimens were analyzed by LC-MS/MS. Selected proteins were evaluated, using immunohistochemical analysis, to determine whether they would be appropriate biomarkers. Finally, we generated biomarker panels to improve diagnostic accuracy. We applied these panels to clinically difficult cases (cases in which different diagnoses were made before and after operation). RESULTS: Consequently, 1820 proteins were detected using LC-MS/MS. Fifteen differentially expressed proteins were selected as candidates based on semi-quantitative comparison. We first performed immunohistochemical staining on samples from the small cohort group (12 PHCs and 12 DCCs) using 15 candidates. KRT17, ANXA10, TMEM109, PTMS, and ATP1B1 showed favorable performances and were tested in the next large cohort group (72 PHCs and 74 DCCs). Based on immunohistochemical analysis, KRT17 performed best for the diagnosis of PHC as a single marker; additionally, PTMS exhibited good performance for the diagnosis of DCCs. Moreover, we indicated the KRT17+/ANXA10+/PTMS- staining pattern as a biomarker panel for the correct diagnosis of PHC and KRT17-/ANXA10-/PTMS+ for the diagnosis of DCC. After immunohistochemical staining for examining samples from the clinically difficult cases, these panels showed satisfactory diagnostic performance with 85.7% (6/7) accuracy. CONCLUSIONS: We conclude that 5 proteins and 2 biomarker panels are promising for distinguishing PHC from DCC, and patients with an equivocal diagnosis would benefit from the application of these biomarkers. Confirmatory studies are needed to generalize these findings to other populations.

  1157. 膵癌肝転移に対する肝切除の適応

    伊関 雅裕, 森川 孝則, 畠 達夫, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-7　2019/04

    Publisher: (一社)日本外科学会

  1158. アミノ酸プロファイルに基づく膵良悪性疾患鑑別因子の検討

    川口 桂, 水間 正道, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-8　2019/04

    Publisher: (一社)日本外科学会

  1159. Serotonin産生膵神経内分泌腫瘍(PanNEN)の臨床病理学的検討

    三浦 孝之, 青木 豪, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 笹野 公伸, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-1　2019/04

    Publisher: (一社)日本外科学会

  1160. 細胞診陽性切除可能膵癌に対するコンバージョン切除を企図した取り組み

    有明 恭平, 水間 正道, 元井 冬彦, 林 洋毅, 中川 圭, 大塚 英郎, 石田 晶玄, 益田 邦洋, 川口 桂, 高館 達之, 三浦 孝之, 伊関 雅裕, 畠 達夫, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-7　2019/04

    Publisher: (一社)日本外科学会

  1161. 肝門部領域胆管癌の至適手術適応の検討

    中川 圭, 益田 邦洋, 高舘 達之, 伊関 雅裕, 畠 達夫, 三浦 孝之, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 宮城 重人, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-1　2019/04

    Publisher: (一社)日本外科学会

  1162. 遠位胆管癌の治療成績と補助化学療法の有用性

    益田 邦洋, 中川 圭, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-6　2019/04

    Publisher: (一社)日本外科学会

  1163. 膵頭十二指腸切除術後の膵液瘻に対する感染対策 ドレーン検査と炎症反応による早期診断と治療介入の応用性

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-5　2019/04

    Publisher: (一社)日本外科学会

  1164. 経口避妊薬内服中の若年女性に発生し増大傾向を示した肝focal nodular hyperplasiaの一例

    宮崎 勇希, 原 康之, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 藤島 史喜, 海野 倫明, 亀井 尚

    肝臓　60　(4)　127-134　2019/04

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  1165. 非アルコール性脂肪性肝炎を背景とした微小肝細胞がんの高精度検出および高感度病理解析

    太田 嶺人, 宇根 範和, 西村 隆一, 宮城 重人, 海野 倫明, 権田 幸祐

    肝臓　60　(Suppl.1)　A464-A464　2019/04

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  1166. 転移再発大腸癌に対する治療と成績 EXPERT試験 KRAS野生型切除可能大腸癌肝転移に対する術後補助化学療法mFOLFOX6と周術期化学療法mFOLFOX6+セツキシマブの第III相ランダム化比較試験

    石榑 清, 長谷川 潔, 齋浦 明夫, 大場 大, 山口 研成, 植竹 宏之, 吉野 孝之, 森田 智視, 高橋 慶一, 海野 倫明, 島田 安博, 室 圭, 吉田 和弘, 森 正樹, 馬場 秀夫, 島田 光生, 三瀬 祥弘, 松村 優, 當山 鉄男, 杉原 健一, 國土 典宏, EXPERT研究グループ

    日本外科学会定期学術集会抄録集　119回　SY-4　2019/04

    Publisher: (一社)日本外科学会

  1167. 人工知能がもたらす外科の将来像 機械学習の外科臨床への応用

    石田 晶玄, 森川 孝則, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　WS-1　2019/04

    Publisher: (一社)日本外科学会

  1168. 膵癌におけるBACH1の機能

    佐藤 正規, 大塚 英郎, 松本 光代, 齋木 由利子, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-8　2019/04

    Publisher: (一社)日本外科学会

  1169. 膵癌間質プロテオミクスによる新規リンパ節転移関連因子ヘモペキシンの発見

    鈴木 ゆき恵, 高館 達之, 水間 正道, 島 弘季, 鈴木 貴, 橘 知睦, 志村 充広, 畠 達夫, 伊関 雅裕, 川口 桂, 青木 豪, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-5　2019/04

    Publisher: (一社)日本外科学会

  1170. 膵癌細胞株における放射線照射によるdCK活性増加を介したGEM感受性亢進作用の解明

    高橋 裕季, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-5　2019/04

    Publisher: (一社)日本外科学会

  1171. 乳癌におけるアミノ酸トランスポーターの発現と治療による変化 Peer-reviewed

    佐藤 未来, 原田 成美, 宮下 穰, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣, 鈴木 貴, 笹野 公伸

    日本外科学会定期学術集会抄録集　119回　PS-1　2019/04

    Publisher: (一社)日本外科学会

  1172. 多職種介入によるNSTの現状と問題点 Peer-reviewed

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-1　2019/04

    Publisher: (一社)日本外科学会

  1173. 当科における12歳未満の小児生体肝移植の成績について Peer-reviewed

    藤尾 淳, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-6　2019/04

    Publisher: (一社)日本外科学会

  1174. [A Case of Curatively Resected Rectal Cancer with Preservation of Urinary Function after Chemotherapy]. Peer-reviewed

    Yasushi Mochizuki, Hideaki Karasawa, Norikazu Une, Shinobu Ohnuma, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Naoki Tanaka, Hiroaki Musha, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　46　(4)　820-822　2019/04

    ISSN： 0385-0684

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    A55 -year-old man was diagnosed with rectal cancer invading the urinary bladder and swollen para-aortic lymph nodes. Since distant metastasis was indicated and total pelvic exenteration was required, 6 courses of chemotherapy with mFOLFOX6 plus panitumumab were performed. After the chemotherapy, the rectal cancer and para-aortic lymph nodes significantly decreased in size, and novel distant metastasis was not observed in CT scans. Therefore, the tumor was considered resectable, and operation was performed. Intraoperative frozen section analysis showed that the para-aortic lymph nodes and surgical margin of the urinary bladder were negative. Thus, low anterior resection of the rectum and partial resection of the urinary bladder were performed. R0 resection was pathologically achieved, and adjuvant chemotherapy with S-1 was administered for 6 months. The patient is alive without recurrence for 10 months. Upfront chemotherapy can be a strategy for advanced rectal cancer with urinary bladder invasion to avoid total pelvic exenteration.

  1175. How does presurgical chemotherapy influence the efficiency of treatment for esophageal cancer recurrence after curative esophagectomy? International-journal Peer-reviewed

    Yusuke Taniyama, Tadashi Sakurai, Makoto Hikage, Hiroshi Okamoto, Chiaki Sato, Kai Takaya, Michiaki Unno, Takashi Kamei

    Thoracic cancer　10　(4)　769-774　2019/04

    DOI： 10.1111/1759-7714.12996 　

    ISSN： 1759-7706

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    BACKGROUND: The effectiveness of treatments for recurrent esophageal squamous cell carcinoma (ESCC), particularly chemotherapy and chemoradiotherapy (CRT), remains unclear in patients who have previously been administered the same drugs during neoadjuvant chemotherapy. METHODS: In this retrospective study, 117 patients with recurrent thoracic ESCCs who had undergone curative resection were included. Patients were divided into two groups based on presurgical treatment: no presurgical treatment (n = 74), and neoadjuvant chemotherapy (n = 43). Prognosis after recurrence was analyzed differently in the group of patients who received CRT and chemotherapy for a recurrent site because of differences in recurrence patterns. RESULTS: There were no differences in patterns and times to recurrence between the patients who underwent each presurgical treatment. For treatment of recurrence, CRT was administered to 66 patients, chemotherapy to 32, surgical resection to 5, and best supportive care to 14. In patients who underwent CRT for local recurrence, the survival rates of those administered neoadjuvant chemotherapy were similar to those who did not receive any presurgical treatment (P = 0.706). In patients who underwent chemotherapy for distant metastasis, the survival rates of those administered neoadjuvant chemotherapy were worse than in those who did not receive any presurgical treatment (P = 0.028). CONCLUSIONS: The effects of CRT for recurrent cancers are not influenced by neoadjuvant chemotherapy, even when using the same anticancer agent. Chemotherapy is an acceptable treatment for patients who do not receive presurgical treatment.

  1176. Expression of SNAIL in accompanying PanIN is a key prognostic indicator in pancreatic ductal adenocarcinomas. International-journal Peer-reviewed

    Sho Fujiwara, Yuriko Saiki, Kota Ishizawa, Shinichi Fukushige, Mie Yamanaka, Masaki Sato, Masaharu Ishida, Fuyuhiko Motoi, Michiaki Unno, Akira Horii

    Cancer medicine　8　(4)　1671-1678　2019/04

    DOI： 10.1002/cam4.2016 　

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    Pancreatic ductal adenocarcinoma (PDAC) is the most lethal cancer, mainly because of its invasive and metastatic characteristics. Pancreatic intraepithelial neoplasia (PanIN) is one of the major precursor lesions of PDAC. Although epithelial-to-mesenchymal transition (EMT) is known to play an important role for these malignant behaviors, the association between PanIN and EMT has not been clearly understood. Therefore, we explored possible molecules for regulation of EMT immunohistochemically. Using surgically resected specimens from 71 PDAC patients, expressions of SNAIL, SLUG, TWIST1, and ZEB1 were investigated in high-grade PanIN (HG-PanIN) and PDAC. Results demonstrated that PDAC accompanied by SNAIL-positive HG-PanIN showed a significantly better relapse-free survival (RFS) (median survival time (MST) of 11.3 months vs 4.4 months, P < 0.001) and overall survival overall survival (OS) (MST of 25.2 months vs 13.6 months, P < 0.001). In PDAC accompanied by SLUG-positive HG-PanIN, RFS and OS (P = 0.09 and P = 0.05) tended to have a better prognosis. In contrast, we could not find any significant prognostic benefits in the expression of TWIST1 or ZEB1 in PDAC accompanied by HG-PanIN. Our present results suggest that (1) EMT may play an important role in the development of PDAC from HG-PanIN, and (2) SNAIL may predict a distinct subgroup that shows a better prognosis.

  1177. Long-term outcome following neoadjuvant therapy for resectable and borderline resectable pancreatic cancer compared to upfront surgery: a meta-analysis of comparative studies by intention-to-treat analysis. Peer-reviewed

    Michiaki Unno, Tatsuo Hata, Fuyuhiko Motoi

    Surgery today　49　(4)　295-299　2019/04

    DOI： 10.1007/s00595-019-01786-w 　

    ISSN： 0941-1291

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    The aim of the study was to evaluate the effect of neoadjuvant therapy on long-term survival in patients with resectable and borderline resectable pancreatic cancer. A meta-analysis was conducted using the reported randomized, controlled trials and retrospective studies using an intention-to-treat analysis to compare upfront surgery and neoadjuvant therapy in resectable or borderline resectable pancreatic cancer patients. Six comparative studies consisting of two randomized, controlled trials and four retrospective studies were included. The overall pooled hazard ratio was 0.66 (95% confidence interval: 0.50-0.87, P = 0.003), indicating that patients in the neoadjuvant group had better long-term survival than those in the upfront surgery group. However, considerable inter-study heterogeneity was observed (I2 = 62%). This meta-analysis focusing on comparative studies analyzed by intention-to-treat analysis showed that neoadjuvant therapy for resectable and borderline resectable pancreatic cancer tends to improve patients' long-term outcomes. However, the evidence level remains too low for a firm conclusion. The well-designed, randomized, controlled trials now ongoing will provide the definite evidence needed in the future.

  1178. Decreased serum carbohydrate antigen 19-9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients. International-journal Peer-reviewed

    Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Kenichiro Uemura, Ken-Ichi Okada, Ippei Matsumoto, Minako Nagai, Hiroaki Yanagimoto, Masanao Kurata, Takumi Fukumoto, Masamichi Mizuma, Hiroki Yamaue, Michiaki Unno

    BMC cancer　19　(1)　252-252　2019/03/21

    DOI： 10.1186/s12885-019-5460-4 　

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    BACKGROUND: Carbohydrate antigen (CA) 19-9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19-9 levels after neoadjuvant therapy has not been clarified. This study aimed to define the prognostic significance of decreased CA19-9 levels after neoadjuvant therapy in patients with pancreatic adenocarcinoma. METHODS: Between 2001 and 2012, 240 consecutive patients received neoadjuvant therapy and subsequent resection at seven high-volume institutions in Japan. These patients were divided into three groups: Normal group (no elevation [≤37 U/ml] before and after neoadjuvant therapy), Responder group (elevated levels [> 37 U/ml] before neoadjuvant therapy but decreased levels [≤37 U/ml] afterwards), and Non-responder group (elevated levels [> 37 U/ml] after neoadjuvant therapy). Analyses of overall survival and recurrence patterns were performed. Uni- and multivariate analyses were performed to clarify the clinicopathological factors influencing overall survival. The initial metastasis sites were also evaluated in these groups. RESULTS: The Responder group received a better prognosis than the Non-responder group (3-year overall survival: 50.6 and 41.6%, respectively, P = 0.026), but the prognosis was comparable to the Normal group (3-year overall survival: 54.2%, P = 0.934). According to the analysis of the receiver operating characteristic curve, the CA19-9 cut-off level defined as no elevation after neoadjuvant therapy was ≤103 U/ml. The multivariate analysis revealed that a CA19-9 level ≤ 103 U/ml, (P = 0.010, hazard ratio: 1.711; 95% confidence interval: 1.133-2.639), tumor size ≤27 mm (P = 0.040, 1.517; (1.018-2.278)), a lack of lymph node metastasis (P = 0.002, 1.905; (1.276-2.875)), and R0 status (P = 0.045, 1.659; 1.012-2.627) were significant predictors of overall survival. Moreover, the Responder group showed a lower risk of hepatic recurrence (18%) compared to the Non-responder group (31%), though no significant difference in loco-regional, peritoneal or other distant recurrence were observed between groups (P = 0.058, P = 0.700 and P = 0.350, respectively). CONCLUSIONS: Decreased CA19-9 levels after neoadjuvant therapy predicts a better prognosis, with low incidence of hepatic recurrence after surgery.

  1179. 内視鏡治療後に追加切除を行った直腸神経内分泌腫瘍症例の検討

    大沼 忍, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 鈴木 ゆき恵, 金原 圭吾, 伊勢 一郎, 相澤 卓, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A360-A360　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1180. 消化器領域における幹細胞研究とその応用 肝障害モデルに対するMuse細胞移植

    伊関 雅裕, 水間 正道, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A87-A87　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1181. 膵癌腹腔洗浄細胞診陽性症例に対するupfront surgeryの限界とconversion surgeryの展望

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 大塚 英郎, 石田 晶玄, 益田 邦洋, 川口 桂, 高舘 達之, 伊関 雅裕, 畠 達夫, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A291-A291　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1182. 切除企図膵癌に対する血中循環DNAのKRAS変異は画像診断で検出困難な微小病変の存在を予測しうるか?

    畠 達夫, 水間 正道, 元井 冬彦, 高舘 達之, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A315-A315　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1183. 胆管癌術前診断と手術切除の現状

    中川 圭, 益田 邦洋, 畠 達夫, 伊関 雅裕, 有明 恭平, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A465-A465　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1184. 食道アカラシア術後残存胸痛に対するPOEMが有効だった一例

    佐藤 千晃, 櫻井 直, 谷山 裕亮, 日景 允, 高屋 快, 今野 卓朗, 小関 健, 安藤 涼平, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会雑誌　116　(臨増総会)　A428-A428　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1185. 【温故知新-胆石の成因別/病態別治療法を考える】胆道内圧測定法 Peer-reviewed

    内藤 剛, 畠 達夫, 伊関 雅裕, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 海野 倫明

    胆と膵　40　(3)　203-206　2019/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1186. Laparoscopic partial liver resection improves the short-term outcomes compared to open surgery for liver tumors in the posterosuperior segments. Peer-reviewed

    Takanori Morikawa, Masaharu Ishida, Tatsuyuki Takadate, Takeshi Aoki, Hideo Ohtsuka, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Surgery today　49　(3)　214-223　2019/03

    DOI： 10.1007/s00595-018-1719-7 　

    ISSN： 0941-1291

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    PURPOSE: The aim of this study was to compare the clinical outcomes between laparoscopic partial liver resection and open partial hepatectomy for tumors in the posterosuperior segments. METHODS: The clinical outcomes of patients who underwent either laparoscopic (n = 20) or open (n = 44) resection in segments 7/8 of the liver were initially evaluated. Because of disparities in the background characteristics, a case-matched study (1:1) was conducted. In addition, a comparative study of the patients who met the institutional criteria for laparoscopic partial hepatectomy was performed. RESULTS: In the case-matched study, the laparoscopic technique required a longer operation time (p = 0.001), but was associated with less intraoperative blood loss (p = 0.021), a lower incidence of major complications (p = 0.014), higher levels of serum albumin on postoperative days 3 and 7 (p = 0.031 and p = 0.035), and earlier discharge (p = 0.001) than open resection. The results of the latter study were similar to those of the case-matched analysis. CONCLUSIONS: Laparoscopic partial hepatectomy was a feasible procedure for treating tumors in the posterosuperior segments without compromising oncological safety and yielded better short-term outcomes than open techniques. In addition, this study provides concrete selection criteria for laparoscopic partial hepatectomy for difficult lesions.

  1187. 腸閉塞に対する高気圧酸素療法

    小野 智之, 工藤 克昌, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(2)　256-260　2019/02

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1188. 膵切除後仮性動脈瘤の治療戦略 膵頭十二指腸切除術術後出血の治療とその成績

    森川 孝則, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 高瀬 圭, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　323-323　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1189. 膵仮性嚢胞・WONへのアプローチ〜各診療科の立場から step-up approachにおけるネクロセクトミーの位置づけ

    伊関 雅裕, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　330-330　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1190. 術中偶発症に対するリカバリーショット 肝胆膵手術における肝動脈に関わる術中偶発症とその対策

    石田 晶玄, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 宮城 重人, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　335-335　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1191. video-assisted retroperitoneal debridment(VARD)が有効であった急性膵炎の1例

    岩渕 蒼太, 石田 晶玄, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　377-377　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1192. 感染性腹部大動脈瘤の術中主膵管損傷による術後膵液瘻に対して瘻孔空腸吻合術を施行した1例

    遠山 慎吾, 水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 益田 邦洋, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 土田 憲, 赤松 大二朗, 後藤 均, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　432-432　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1193. 初回手術14年後に再発をきたした膵Solid-pseudopapillary neoplasmに対して腹腔動脈合併残膵切除を施行した1例

    千葉 和治, 畠 達夫, 元井 冬彦, 水間 正道, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 籔内 伸一, 大森 優子, 古川 徹, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　206回　75-75　2019/02

    Publisher: 日本消化器病学会-東北支部

  1194. 抗ドナー血液型抗体価4096倍のABO血液型不適合生体肝移植症例の経験 脱感作療法の重要性について Peer-reviewed

    齋藤 純健, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆, 佐々木 健吾, 福岡 健吾, 柿崎 裕太, 後藤 昌史, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　206回　84-84　2019/02

    Publisher: 日本消化器病学会-東北支部

  1195. Sustained Elevation of Postoperative Serum Level of Carbohydrate Antigen 19-9 is High-Risk Stigmata for Primary Hepatic Recurrence in Patients with Curatively Resected Pancreatic Adenocarcinoma. International-journal Peer-reviewed

    Fuyuhiko Motoi, Yoshiaki Murakami, Ken-Ichi Okada, Ippei Matsumoto, Kenichiro Uemura, Sohei Satoi, Masayuki Sho, Goro Honda, Takumi Fukumoto, Hiroaki Yanagimoto, Shoichi Kinoshita, Masanao Kurata, Shuichi Aoki, Masamichi Mizuma, Hiroki Yamaue, Michiaki Unno

    World journal of surgery　43　(2)　634-641　2019/02

    DOI： 10.1007/s00268-018-4814-4 　

    ISSN： 0364-2313

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    BACKGROUND: Survival after surgery for pancreatic adenocarcinoma (PA) is poor and heterogeneous, even for curative (R0) resection. Serum carbohydrate antigen (CA) 19-9 levels are important prognostic markers for resected PA. However, sustained elevation of CA19-9 in association with the patterns of recurrence has been rarely investigated. METHODS: Patients who underwent R0 resection (n = 539) were grouped according to postoperative serum CA19-9 levels (Group E: sustained elevation; Group N: no elevation). Clinicopathological factors, patterns of recurrence, and survival were compared between the groups. RESULTS: Group E (n = 159) had significantly shorter median overall survival (17.1 vs. 35.4 months, p < 0.0001) than Group N (n = 380). Postoperative CA19-9 elevation was a significant independent predictor of poor survival in multivariate analysis (hazard ratio 1.98, p < 0.0001). The rate of hepatic recurrence in Group E was 2.6-fold higher than in Group N (45% vs. 17%, p < 0.0001). Postoperative CA19-9 elevation was a strongest independent predictor of primary hepatic recurrence (p < 0.0001) by a multiple regression model. Loco-regional, peritoneal, and other distant recurrence did not differ between the groups. The extent of preoperative CA19-9 elevation was correlated sustained elevation of CA19-9 after surgery (p < 0.0001) and primary hepatic recurrence (p = 0.0019). CONCLUSIONS: Sustained CA19-9 elevation was strong predictor of primary hepatic recurrence and short survival in cases of R0 resection for PA.

  1196. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05). International-journal Peer-reviewed

    Fuyuhiko Motoi, Tomoo Kosuge, Hideki Ueno, Hiroki Yamaue, Sohei Satoi, Masayuki Sho, Goro Honda, Ippei Matsumoto, Keita Wada, Junji Furuse, Yutaka Matsuyama, Michiaki Unno

    Japanese journal of clinical oncology　49　(2)　190-194　2019/02/01

    DOI： 10.1093/jjco/hyy190 　

    ISSN： 0368-2811

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    A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer. Patients were enrolled after the diagnosis of resectable or borderline resectable by portal vein involvement pancreatic cancer with histological confirmation. They were randomly assigned to either neoadjuvant chemotherapy or upfront surgery. Adjuvant chemotherapy using S-1 was administered for 6 months to patients with curative resection who fully recovered within 10 weeks after surgery in both arms. The primary endpoint is overall survival; secondary endpoints include adverse events, resection rate, recurrence-free survival, residual tumor status, nodal metastases and tumor marker kinetics. The target sample size was required to be at least 163 (alpha-error 0.05; power 0.8) in both arms. A total of 360 patients were required after considering ineligible cases. This trial began in January 2013 and was registered with the UMIN Clinical Trials Registry (UMIN000009634).

  1197. Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Arun S Singh, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Shree Ram Singh, Fritz C Eilber, Robert M Hoffman

    Journal of drug targeting　27　(2)　211-216　2019/02

    DOI： 10.1080/1061186X.2018.1499748 　

    ISSN： 1061-186X

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    Undifferentiated/unclassified soft tissue sarcoma (USTS) is a recalcitrant disease; therefore, precise individualised therapy is needed. Toward this goal, we previously established patient-derived orthotopic xenograft (PDOX) models of USTS in nude mice. Here, we determined the extent of uniqueness of drug response in a panel on USTS PDOX models from 5 different patients. We previously showed that 3 of the 5 patients were resistant to doxorubicin (DOX) despite DOX being first-line therapy. Two weeks after orthotopic tumour implantation, PDOX mouse models were randomised into five groups: untreated control, DOX, gem-citabine/docetaxel (GEM/DOC), pazopanib (PAZ), temozolomide (TEM). Three PDOX cases were completely resistant to DOX. TEM had high efficacy for 4 USTS PDOX models, including DOX-resistant cases. GEM/DOC and PAZ were effective in three USTS PDOX. One case was completely resistant to TEM. Two cases were completely resistant to PAZ. The results showed the drug sensitivity pattern for each USTS PDOX was highly individualised and that at least one effective drug could be found for each. The PDOX model could be effective in precise individualised drug sensitivity testing which is especially important for heterogeneous cancers such as USTS, and can give the patient a greater chance to be treated with an effective drug.

  1198. Current status of projects for developing cancer-related clinical practice guidelines in Japan and recommendations for the future. Peer-reviewed

    Masafumi Imamura, Koichi Hirata, Michiaki Unno, Kinj Kamiya, Mitsukazu Gotoh, Hiroyuki Konno, Akiko Shibata, Kenichi Sugihara, Arata Takahashi, Masahiko Nishiyama, Kenichi Hakamada, Tsuguya Fukui, Toshiharu Furukawa, Tsunekazu Mizushima, Masamichi Mizuma, Hiroaki Miyata, Masaki Mori, Ichiro Takemasa, Toru Mizuguchi, Toshiyoshi Fujiwara

    International journal of clinical oncology　24　(2)　189-195　2019/02

    DOI： 10.1007/s10147-018-1340-1 　

    ISSN： 1341-9625

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    BACKGROUND: The current status and adoption of cancer-related clinical practice guidelines in Japan has not been elucidated yet. The purpose of this study was to propose roles and suggestions to develop future cancer-related clinical guidelines. METHODS: A questionnaire consisting of four domains with a total of 17 questions was developed. We distributed the questionnaire to 28 specific academic organizations in Japan which have developed any cancer-related clinical practice guidelines and which were funded by the Ministry of Health, Labor, and Welfare. RESULTS: Most organizations have investigated nationwide dissemination and adoption of clinical practice guidelines. The rate of adoption in clinical practice was estimated at approximately ≥ 70%. However, organizations with smaller budgets reported surveying approximately 60% of the time, whereas the ones with larger budgets reported approximately 100% success in surveying about their guidelines. The presidents of the organizations agreed that a new organization operated directly by the national government was necessary. CONCLUSION: In Japan, to develop cancer-related clinical practice guidelines, a study of clinical validation is necessary. Sufficient funds must be available to support the project to maintain and revise the guidelines. Furthermore, legal and ethical issues should be solved before establishing any registry system.

  1199. A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study. Peer-reviewed

    Fuyuhiko Motoi, Sohei Satoi, Goro Honda, Keita Wada, Hiroyuki Shinchi, Ippei Matsumoto, Masayuki Sho, Akihiko Tsuchida, Michiaki Unno

    Journal of gastroenterology　54　(2)　194-203　2019/02

    DOI： 10.1007/s00535-018-1506-7 　

    ISSN： 0944-1174

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    BACKGROUND: Neoadjuvant chemotherapy (NAC) represents a promising alternative to pancreatic ductal adenocarcinoma (PDAC) planned resection, but the survival impact remains undefined. To assess the feasibility and survival outcomes of NAC with gemcitabine and S1 (GS) for PDAC planned resection by prospective study. METHODS: Patients with resectable or borderline resectable PDAC received 2 cycles of NAC-GS and were offered curative resection followed by gemcitabine adjuvant. The primary endpoint was 2-year overall survival (OS). Adverse events during NAC, radiological and tumor marker responses, resection rate, and surgical safety were evaluated as secondary endpoints (UMIN000004148). RESULTS: We enrolled 104 patients between 2010 and 2012, with 101 patients treated using NAC-GS as the full analysis set (FAS). Of the 101 patients, 88% received the planned 2 cycles of NAC. Grade 3 neutropenia was common (35%). Radiological partial response and decreased carbohydrate antigen 19-9 concentration (> 50% decrease) were noted in 13% and 41%, respectively. R0/1 resections with M0 were performed in 65 patients without surgical mortality. Of the 65 patients, 44 received planned gemcitabine adjuvant for 6 months as the on-protocol cohort. The primary endpoint for the 2-year OS rate was 55.9% in the FAS (n = 101) and 74.6% in the on-protocol cohort (n = 44). CONCLUSIONS: NAC-GS was feasible and actively prolonged survival following PDAC planned resection. Randomized control trials are needed to further clarify the survival benefit of NAC-GS in addition to surgery followed by adjuvant therapy.

  1200. Combination of longitudinal pancreaticojejunostomy with coring-out of the pancreatic head (Frey procedure) and distal pancreatectomy for chronic pancreatitis. Peer-reviewed

    Hideaki Sato, Masaharu Ishida, Fuyuhiko Motoi, Naoaki Sakata, Takeshi Aoki, Hideyuki Suzuki, Akihiro Yamamura, Hideaki Karasawa, Tatsuo Hata, Hideo Ohtsuka, Masamichi Mizuma, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Takashi Kamei, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno

    Surgery today　49　(2)　137-142　2019/02

    DOI： 10.1007/s00595-018-1720-1 　

    ISSN： 0941-1291

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    PURPOSE: The Frey procedure is an effective surgery for chronic pancreatitis (CP) patients who have pancreatic head lesions with dilation of the main pancreatic duct. However, pancreatic tail lesions can cause relapsing pancreatitis after the procedure. Therefore, additional distal pancreatectomy (DP) might complement the therapeutic effect of the Frey procedure in controlling inflammation of the pancreatic tail. The Frey procedure with DP (Frey + DP) is indicated for inflammatory lesions in the pancreatic head and tail. In this study, we assessed the usefulness of Frey + DP using the retrospective clinical data of our cases. METHODS: The clinical outcomes were compared between CP patients who underwent the Frey procedure (N = 44) and Frey + DP (N = 13) from January 2005 to April 2016. RESULTS: Frey + DP showed similarly good therapeutic effects to the Frey procedure with regard to the postoperative stay, morbidity, mortality, pain relief and nutrition, although the Frey + DP had a longer operative time, more bleeding and higher incidence of diabetes mellitus than the Frey procedure because of the additional DP. One patient in the Frey group received additional DP because of recurrent pain due to the tail lesion. CONCLUSION: Frey + DP can be a promising treatment for CP patients with pancreatic head and tail lesions.

  1201. Thoracoscopic esophagectomy with subcarinal lymph node dissection in the prone position for esophageal cancer with a right superior pulmonary vein anomaly: a case report. International-journal Peer-reviewed

    Yu Onodera, Yusuke Taniyama, Tadashi Sakurai, Makoto Hikage, Chiaki Sato, Kai Takaya, Hiroshi Okamoto, Shota Maruyama, Takuro Konno, Michiaki Unno, Takashi Kamei

    Surgical case reports　5　(1)　6-6　2019/01/14

    DOI： 10.1186/s40792-019-0567-z 　

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    BACKGROUND: Superior posterior pulmonary vein anomaly in the right upper lobe (anomalous V2), which is one of the anomalies of the right superior pulmonary vein (RSPV), runs behind the right main or intermediate bronchus. Although this rarely occurs, attention should be given to this venous anomaly during thoracoscopic esophagectomy with subcarinal lymph node dissection. Here, we report a case of thoracoscopic esophagectomy with subcarinal lymph node dissection in the prone position for lower thoracic esophageal cancer with anomaly of the superior posterior pulmonary vein in the right lobe (anomalous V2). CASE PRESENTATION: A 61-year-old man was diagnosed as having lower esophageal cancer with swelling of multiple lymph nodes in the mediastinum and abdomen. His clinical diagnosis based on the eighth TNM classification system was cT3 N2 M0 stage IIIB. In addition, an anomalous V2 was recognized on preoperative computed tomography imaging before the operation. The vein ran behind the intermediate bronchus and drained into the RSPV located at the area of the subcarinal lymph node. We performed preoperative simulation by using virtual thoracoscopic imaging with the same view as that during operation to help us better dissect the lymph nodes. As a result, thoracoscopic esophagectomy and subcarinal lymph node dissection were performed in the prone position without injuring the anomalous V2. Severe complications did not occur in the postoperative course except for paralysis of the left recurrent laryngeal nerve. The patient was discharged on postoperative day 17. CONCLUSIONS: Injury to an anomalous V2 can cause severe hemorrhage during subcarinal lymph node dissection in esophagectomy. Preoperative simulation by using virtual thoracoscopic imaging is useful to avoid this complication in patients with an anatomical anomaly.

  1202. Pediatric Living-Donor Liver Transplant Recipients without Transition After Reaching Adulthood. International-journal Peer-reviewed

    Chikashi Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Annals of transplantation　24　18-24　2019/01/08

    DOI： 10.12659/AOT.911544 　

    ISSN： 1425-9524

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    BACKGROUND Transition to adult care can trigger certain problems for pediatric liver transplant recipients. At our institution, the same transplant team performs both adult and pediatric liver transplantation and post-transplant care; thus, pediatric liver transplant recipients do not have to be transferred. However, it is unclear whether this system affects the recipient's outcome during the transition period. Therefore, we retrospectively assessed pediatric liver transplant recipients who reached adulthood at our institution. MATERIAL AND METHODS This was a single-center, retrospective study involving consecutive pediatric living-donor liver transplant recipients who reached the age of 18 by October 2017. A total of 36 recipients, 20 females and 16 males, were included in the study. RESULTS The 5- and 10-year patient survival after reaching the age of 18 was 100% and 93%, respectively. All of the 3 patients who died had been suffering from secondary biliary cirrhosis due to biliary stricture. In 5 patients (13.9%), biliary stricture became symptomatic or recurred after reaching the age of 18 years. Late-onset acute rejection and chronic rejection developed in 2 (5.6%) and 4 patients (11.1%), respectively. Only 4 (11.1%) patients were obviously noncompliant. We found no significant association between compliance and rejection or survival. Among the patients who are 18 years old and older, 5 (13.9%) had a psychiatric diagnosis. CONCLUSIONS Pediatric liver transplant recipients who underwent transplant surgery and received post-transplant care at our institution have good long-term outcomes. This suggests that having the same team perform both adult and pediatric transplantation and post-transplant care is beneficial for young adult recipients.

  1203. A case of progressive focal nodular hyperplasia developed in a young patient taking oral contraceptives

    Yuki Miyazaki, Yasuyuki Hara, Shigehito Miyagi, Chikashi Nakanishi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

    Acta Hepatologica Japonica　60　(4)　127-134　2019

    Publisher: Japan Society of Hepatology

    DOI： 10.2957/kanzo.60.127 　

    ISSN： 1881-3593 0451-4203

  1204. 右上肺静脈異常を伴う食道癌に対する腹臥位での気管分岐部リンパ節郭清を伴う胸腔鏡下食道切除術 1症例報告(Thoracoscopic esophagectomy with subcarinal lymph node dissection in the prone position for esophageal cancer with a right superior pulmonary vein anomaly: a case report)

    Onodera Yu, Taniyama Yusuke, Sakurai Tadashi, Hikage Makoto, Sato Chiaki, Takaya Kai, Okamoto Hiroshi, Maruyama Shota, Konno Takuro, Unno Michiaki, Kamei Takashi

    Surgical Case Reports　5　(January)　1-5　2019/01

    Publisher: Springer Berlin Heidelberg

    eISSN： 2198-7793

  1205. 多領域に血栓が充満したVTEに対する血管内治療の役割 Peer-reviewed

    梅津 道久, 後藤 均, 赤松 大二朗, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 小笠原 紀信, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　28　(Suppl.)　O9-4　2019

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  1206. 【Muse細胞-現状と将来展望-】肝硬変におけるMuse細胞を用いた治療戦略 Invited

    伊関 雅裕, 水間 正道, 海野 倫明

    血液フロンティア　29　(2)　243-247　2019/01

  1207. Strategy towards tailored donor tissue-specific pancreatic islet isolation. International-journal Peer-reviewed

    Yuki Miyazaki, Kazutaka Murayama, Ibrahim Fathi, Takehiro Imura, Youhei Yamagata, Kimiko Watanabe, Hiroshi Maeda, Akiko Inagaki, Yasuhiro Igarashi, Shigehito Miyagi, Hiroki Shima, Kazuhiko Igarashi, Takashi Kamei, Michiaki Unno, Masafumi Goto

    PloS one　14　(5)　e0216136　2019

    DOI： 10.1371/journal.pone.0216136 　

    ISSN： 1932-6203

  1208. 【膵全摘術を考える】膵癌に対する膵全摘術の適応と成績 Peer-reviewed

    元井 冬彦, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 亀井 尚, 海野 倫明

    胆と膵　40　(1)　11-16　2019/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1209. Expression of Epithelial-Mesenchymal Transition Proteins in Pancreatic Anaplastic (Undifferentiated) Carcinoma. International-journal Peer-reviewed

    Kazuyuki Ishida, Rina Yamashita, Mitsumasa Osakabe, Noriyuki Uesugi, Noriyuki Yamada, Hiroyuki Nitta, Fumiyoshi Fujishima, Fuyuhiko Motoi, Hiroyoshi Suzuki, Hiromune Shimamura, Yutaka Noda, Takashi Sawai, Michiaki Unno, Hironobu Sasano, Akira Sasaki, Tamotsu Sugai

    Pancreas　48　(1)　36-42　2019/01

    DOI： 10.1097/MPA.0000000000001199 　

    ISSN： 0885-3177

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    OBJECTIVES: The aim of this study was to identify an association of pancreatic anaplastic carcinoma (APC) with the epithelial-mesenchymal transition (EMT). METHODS: Resected APCs (n = 24) were examined to assess components of APCs, including carcinomatous, transitional, and sarcomatous regions. Analysis was performed based on the immunoreactivity of E-cadherin and 3 EMT-related proteins: Slug (zinc finger protein SNAI2), Twist (Twist-related protein 1), and Zeb1 (zinc finger E-box-binding homeobox 1). Expression score was determined based on staining intensity and stained area of the target cells. Finally, we performed a hierarchical clustering based on the expression pattern of E-cadherin and EMT-related proteins of the sarcomatous component. RESULTS: The expression score of E-cadherin decreased in the order of sarcomatous > transitional > carcinomatous components (P < 0.01). Although there were significant differences in the immunohistochemical scores of Slug, Twist, and Zeb1 between carcinomatous and transitional components (P < 0.01), the significant difference in immunohistochemical score of Zeb1 between transitional and sarcomatous components was found (P < 0.05). Furthermore, APCs were divided into 2 subgroups based on the expression patterns of E-cadherin and EMT-related proteins (hierarchical clustering analysis). Consequently, these subgroups were distinguished by Twist expression. CONCLUSIONS: Epithelial-mesenchymal transition plays an essential role in the pathogenesis of APC.

  1210. Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma. International-journal Peer-reviewed

    Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Takanori Morikawa, Tatsuyuki Takadate, Kei Nakagawa, Hiroki Hayashi, Atsushi Kanno, Atsushi Masamune, Takashi Kamei, Toru Furukawa, Takeshi Naitoh, Michiaki Unno

    Pancreas　48　(1)　99-106　2019/01

    DOI： 10.1097/MPA.0000000000001202 　

    ISSN： 0885-3177

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    OBJECTIVES: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma. METHODS: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. RESULTS: The median (interquartile range) preoperative NLR was higher in IPMN with HGD/invasive carcinoma (2.03 [1.48-2.93]) than IPMN with low-grade dysplasia (1.74 [1.42-2.24], P = 0.0137). The C-reactive protein-to-albumin ratio and derived NLR values were also significant higher in cases with HGD/invasive carcinoma. A combination assay of NLR, carcinoembryonic antigen, and carbohydrate antigen 19-9 revealed a 58.8% sensitivity and 76.8% specificity. Among the cases with worrisome features, the high NLR values increased the positive predictive value (68.8%) compared with low values (31.8%). In IPMN cases with the associated invasive carcinoma, high NLR values showed association with the deeper vertical invasion and shorter survival periods. CONCLUSIONS: Preoperative NLR, combined with tumor markers and image findings, can be a useful predictive marker for the presence of HGD/invasive carcinoma in IPMNs. Preoperative NLR also predicts the long-term outcomes in IPMN cases with invasive carcinoma.

  1211. Clinical practice guidelines for IgG4-related sclerosing cholangitis. Peer-reviewed

    Terumi Kamisawa, Takahiro Nakazawa, Susumu Tazuma, Yoh Zen, Atsushi Tanaka, Hirotaka Ohara, Takashi Muraki, Kazuo Inui, Dai Inoue, Takayoshi Nishino, Itaru Naitoh, Takao Itoi, Kenji Notohara, Atsushi Kanno, Kensuke Kubota, Kenji Hirano, Hiroyuki Isayama, Kyoko Shimizu, Toshio Tsuyuguchi, Tooru Shimosegawa, Shigeyuki Kawa, Tsutomu Chiba, Kazuichi Okazaki, Hajime Takikawa, Wataru Kimura, Michiaki Unno, Masahiro Yoshida

    Journal of hepato-biliary-pancreatic sciences　26　(1)　9-42　2019/01

    DOI： 10.1002/jhbp.596 　

    ISSN： 1868-6974

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    IgG4-related sclerosing cholangitis (IgG4-SC) is a distinct type of cholangitis frequently associated with autoimmune pancreatitis and currently recognized as a biliary manifestation of IgG4-related disease. Although clinical diagnostic criteria of IgG4-SC were established in 2012, differential diagnosis from primary sclerosing cholangitis and cholangiocarcinoma is sometimes difficult. Furthermore, no practical guidelines for IgG4-SC are available. Because the evidence level of most articles retrieved through searching the PubMed, Cochrane Library, and Igaku Chuo Zasshi databases was below C based on the systematic review evaluation system of clinical practice guidelines MINDS 2014, we developed consensus guidelines using the modified Delphi approach. Three committees (a guideline creating committee, an expert panelist committee for rating statements according to the modified Delphi method, and an evaluating committee) were organized. Eighteen clinical questions (CQs) with clinical statements were developed regarding diagnosis (14 CQs) and treatment (4 CQs). Recommendation levels for clinical statements were set using the modified Delphi approach. The guidelines explain methods for accurate diagnosis, and safe and appropriate treatment of IgG4-SC.

  1212. Correction: Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease. International-journal Peer-reviewed

    Hirofumi Chiba, Yoichi Kakuta, Yoshitaka Kinouchi, Yosuke Kawai, Kazuhiro Watanabe, Munenori Nagao, Takeo Naito, Motoyuki Onodera, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Kenichi Negoro, Masao Nagasaki, Michiaki Unno, Tooru Shimosegawa

    PloS one　14　(2)　e0212148　2019

    DOI： 10.1371/journal.pone.0212148 　

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    [This corrects the article DOI: 10.1371/journal.pone.0194036.].

  1213. 定型的膵切除術(PD and DP):腹腔鏡VS開腹pros and cons 腹腔鏡下膵尾側切除術は、開腹のQualityを超えられるか?

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　PD13-3　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1214. 小児先天性胆道拡張症手術における腹腔鏡下再建法:細径胆管の吻合法 先天性胆管拡張症成人例に対する腹腔鏡下肝外胆管切除術

    森川 孝則, 大塚 英郎, 石田 晶玄, 高舘 達之, 伊関 雅裕, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 水間 正道, 林 洋毅, 中川 圭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　WS20-7　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1215. 腹腔鏡下肝切除術の定型化に向けたチームでの取り組み

    高舘 達之, 森川 孝則, 石田 晶玄, 畠 達夫, 伊関 雅裕, 三浦 孝之, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS222-1　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1216. 主に部分切除術・外側区域切除術を対象とした、腹腔鏡下肝切除術の周術期成績の検討

    石田 晶玄, 森川 孝則, 高舘 達之, 畠 達夫, 伊関 雅裕, 三浦 孝之, 戸子台 和哲, 青木 豪, 中西 史, 中川 圭, 林 洋毅, 宮城 重人, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS185-3　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1217. Thoracoscopic Esophagectomy for a Patient With Perforated Esophageal Epiphrenic Diverticulum After Kidney Transplantation: A Case Report. International-journal Peer-reviewed

    Y Onodera, T Nakano, T Fukutomi, T Naitoh, M Unno, C Shibata, T Kamei

    Transplantation proceedings　50　(10)　3964-3967　2018/12

    DOI： 10.1016/j.transproceed.2018.08.042 　

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    A 58-year-old man who underwent cadaveric kidney transplantation twice presented to hospital with a perforated epiphrenic diverticulum. Computed tomography revealed epiphrenic diverticulitis and right pleural effusion. Upper gastrointestinal fibroscopy showed an epiphrenic diverticulum full of food residue. He was transferred to our hospital, where we performed percutaneous endoscopic gastrostomy under general anesthesia in the supine position before thoracoscopy. Thoracoscopic esophagectomy was performed in the semi-prone position under 6-10 mmHg artificial pneumothorax via the right thoracic cavity. We performed subtotal esophagectomy to remove sources of infection because the esophageal wall surrounding the diverticulum was too thick to close or to perform diverticulectomy. A cervical esophagostomy was constructed after the thoracic procedure. The patient was managed with continuous hemodiafiltration and administered immunosuppressants and steroids to preserve the transplanted kidney. Continuous hemodiafiltration was stopped on postoperative day (POD) 4. The patient was discharged from the intensive care unit on POD 10 and transferred to the original hospital on POD 24 for rehabilitation. The second operative stage was performed on POD 157 at our hospital. We performed gastric tube reconstruction via the ante-sternal route and anastomosed the tube to the cervical esophagus. The postoperative course was uneventful; the patient was transferred to the original hospital on POD 15 after the second operation. Minimally invasive surgery was sufficient to treat perforated epiphrenic diverticulum while preserving the transplanted kidney. We recommend completely removing the source of infection and reducing surgical invasiveness to preserve the transplanted kidney in cases of esophageal perforation following kidney transplantation.

  1218. 【ここがポイント!-サルコペニアの病態と対処法】周術期管理と手術・治療の留意点 食道手術 食道癌患者とサルコペニアの関係と治療上の留意点 Peer-reviewed

    小澤 洋平, 櫻井 直, 谷山 裕亮, 日景 允, 佐藤 千晃, 高屋 快, 小野寺 優, 今野 卓朗, 内藤 剛, 海野 倫明, 亀井 尚

    臨床外科　73　(13)　1468-1472　2018/12

    Publisher: (株)医学書院

    ISSN： 0386-9857

    eISSN： 1882-1278

  1219. 化学放射線療法と肝動脈血流改変により切除し得た局所進行切除不能膵頭部癌の1例 Peer-reviewed

    遠山 慎吾, 水間 正道, 林 洋毅, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　45　(13)　2309-2311　2018/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1220. FBXW7 modulates malignant potential and cisplatin-induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1. International-journal Peer-reviewed

    Akiko Mori, Kunihiro Masuda, Hideo Ohtsuka, Masahiro Shijo, Kyohei Ariake, Koji Fukase, Naoaki Sakata, Masamichi Mizuma, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Fumiyoshi Fujishima, Michiaki Unno

    Cancer science　109　(12)　3883-3895　2018/12

    DOI： 10.1111/cas.13829 　

    ISSN： 1347-9032

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    The ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is responsible for degrading diverse oncoproteins and is considered a tumor suppressor in many human cancers. Inhibiting FBXW7 enhances the malignant potential of several cancers. In this study, we aimed to investigate the role of FBXW7 in cholangiocarcinoma. We found that FBXW7 expression was associated with clinicopathological outcomes in cholangiocarcinoma patients. Both disease-free and overall survival were significantly worse in the low-FBXW7 group than in the high-FBXW7 group (P = .001 and P < .001, respectively). Multivariate analysis with the Cox proportional hazards model indicated that FBXW7 was the most important independent prognostic factor for disease-free (P = .006) and overall (P = .0004) survival. We also showed that the two FBXW7 substrates, NOTCH1 and myeloid cell leukemia sequence 1 (MCL1), regulate cholangiocarcinoma progression. Depletion of FBXW7 resulted in NOTCH1 accumulation and increased cholangiocarcinoma cell migration and self-renewal. Interestingly, when cells were stimulated with cis-diamminedichloridoplatinum(II) (cisplatin), FBXW7 suppression induced MCL1 upregulation, which reduced the sensitivity of cholangiocarcinoma cells to apoptosis, indicating that FBXW7-mediated ubiquitylation is context-dependent. These results indicate that FBXW7 modulates the malignant potential of cholangiocarcinoma through independent regulation of NOTCH1 and MCL1.

  1221. [A Case of Laparoscopically Resected Giant Rectal Cancer Following Neoadjuvant Chemoradiotherapy]. Peer-reviewed

    Takashi Aizawa, Hideaki Karasawa, Shinobu Ohnuma, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Naoki Tanaka, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(13)　1931-1933　2018/12

    ISSN： 0385-0684

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    A woman in her 40s who presented to a local hospital with bloody stool was referred to our hospital. Colonoscopy showed a rectal tumor, and histological examination showed moderately differentiated adenocarcinoma. CT and MRI revealed that the tumor was 65mm in diameter with no distant metastasis. After the construction of ileostomy, neoadjuvant chemoradiothera- py(NACRT: 45 Gy/25 Fr, S-1 80mg/m2)was performed. The tumor shrank remarkably, and then we performed laparoscopy- assisted low anterior resection. Pathological examination revealed complete disappearance of the cancer cells in the primary site and no appearance of cancer cells in all dissected lymph nodes. NACRT has been recently reported to provide pathological complete response, and these patients are supposed to have a good prognosis. In our case, NACRT enhanced the performance of laparoscopic curative resection while preserving anal function. NACRT should contribute to the curative resection while preserving anal function in patients with locally advanced rectal cancer.

  1222. [Two Cases of Locally Recurrent Rectal Cancer Successfully Treated by Carbon Ion Radiotherapy]. Peer-reviewed

    Keigo Kanehara, Shinobu Ohnuma, Hideyuki Suzuki, Akihiro Yamamura, Hideaki Karasawa, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Naoki Tanaka, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(13)　1940-1942　2018/12

    ISSN： 0385-0684

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    Case 1: A female patient in her 60s underwent laparoscopic intersphincteric resection for rectal cancer. After 42 months, the serum level of carcinoembryonic antigen(CEA)was elevated, and PET-CT showed a locally recurrent rectal cancer that increased FDG-uptake. Carbon ion radiotherapy(CIRT)(73.6 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 12 months. Case 2: A female patient in her 60s underwent abdominoperineal resection for rectal cancer. After 42 months, the serum level of CEA was elevated, and CT revealed a local recurrence of rectal cancer. Subsequently, the tumor was resected; however, resection margin was microscopically positive. Therefore, chemoradiotherapy(S-1, 60 Gy)was performed. At 31 months after local resection, a re-recurrent tumor was noted in her left ischium. Therefore, CIRT(70.4 GyE/16 Fr)was performed. Serum CEA level and FDG-uptake were normalized. No regrowth of tumor has been found for 24 months. CIRT is an effective therapy for locally recurrent rectal cancer.

  1223. [A Small Rectal Neuroendocrine Tumor of Less Than 5mm with Lymph Node Metastasis]. Peer-reviewed

    Shoji Kokubo, Shinobu Ohnuma, Hideyuki Suzuki, Hirofumi Imoto, Akihiro Yamamura, Hideaki Karasawa, Atsushi Kohyama, Takeshi Aoki, Kazuhiro Watanabe, Naoki Tanaka, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(13)　1985-1987　2018/12

    ISSN： 0385-0684

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    According to the treatment guideline for rectal neuroendocrine tumor(NET), tumor with a diameter ofC10mm should be resected endoscopically, while tumor with a diameter of>10mm should be resected surgically with lymph node dissection. We experienced a case of a rectal NET with a diameter of 5mm with lymph node metastasis. A 69-year-old man underwent colonoscopy for positive fecal occult blood test. The colonoscopy revealed a submucosal tumor(SMT)with a diameter of 5 mm in the lower rectum. An endoscopic mucosal resection(EMR)was performed after SMT was diagnosed as NET by biopsy. Histopathological findings were NET-G1, 4.5×2.5 mm, v(+), ly(+). Then, laparoscopically assisted rectal resection with D2 lymph node dissection was performed. In histopathological examination, no tumor residue was observed in the specimu; however, a regional lymph node metastasis was detected. Risk factors of lymph node metastasis with rectal NET are a diameter of>10 mm, recessed or ulcerated surface, and lymphovascular invasion. However, we have to keep in mind that lymph node metastasis may occur even in small rectal NET with a diameter of ≤10mm.

  1224. [Conversion Surgery Combined with Preoperative Coil Embolization of Hepatic Artery for Locally Advanced Unresectable Pancreatic Head Cancer with Hepatic Artery Invasion-A Case Report]. Peer-reviewed

    Shingo Toyama, Masamichi Mizuma, Hiroki Hayashi, Masahiro Iseki, Tatsuyuki Takadate, Kyohei Ariake, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(13)　2309-2311　2018/12

    ISSN： 0385-0684

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    Here we report a case treated with conversion surgery combined with preoperative coil embolization of the hepatic artery after chemoradiation therapy for locally advanced unresectable pancreatic head cancer with hepatic artery invasion. A 63- year-old man was referred to our hospital for treatment of pancreatic cancer. Abdominal CT scan revealed a 30mm pancreatic head tumor with involvement of the common hepatic artery(CHA)and proper hepatic artery(PHA). The left hepatic artery diverged from the left gastric artery. Although S-1 with concurrent radiation therapy was performed, a follow-up CT scan revealed the progression of soft tissue shadow around the CHA. Subsequently, gemcitabine plus nab-paclitaxel(GnP)was administered 13 times. GnP helped achieve normalization of the tumor markers and long stable disease(SD)based on the Response Evaluation Criteria in Solid Tumors(RECIST). For the conversion surgery, embolization of the middle hepatic artery (MHA)was performed. Twelve days after, the right hepatic artery was embolized. Subtotal stomach-preserving pancreaticoduodenectomy was performed with resection of the CHA and PHA without arterial reconstruction 16 days after the hepatic arterial embolization. The patient was discharged from our hospital 33 days after surgery without complications related to hepatic ischemia. The patient is alive without recurrence 42 months after the initial diagnosis and 26 months after surgery.

  1225. Effects of Calcitonin Gene-Related Peptide on Colonic Motility and Defecation in Conscious Dogs. International-journal Peer-reviewed

    Tomoyuki Ono, Munenori Nagao, Hirofumi Imoto, Kazuhiro Watanabe, Naoki Tanaka, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　22　(12)　2097-2103　2018/12

    DOI： 10.1007/s11605-018-3858-y 　

    ISSN： 1091-255X

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    BACKGROUND: Although intra-arterial infusion of calcitonin gene-related peptide (CGRP) reportedly stimulates giant migrating contractions (GMCs) of the small intestine in conscious dogs, the effect of intravenous CGRP administration on colonic motility remains unclear. In the present study, we investigated the effects of intravenous CGRP on colonic motility and defecation and determined the underlying mechanism of action in conscious dogs. METHODS: Sixteen Beagle dogs weighing 11-13 kg were included. The effects of intravenous CGRP at doses of 3.33 (with various antagonists), 0.83, and 1.67 μg/kg on colonic motility and defecation were evaluated in neurally intact dogs (n = 6). For comparison, dogs with transection/re-anastomosis (T/R) between the proximal and middle segments of the colon (n = 5) and dogs with extrinsic denervation of the ileocolonic segments (n = 5) also received intravenous CGRP at 3.33 μg/kg. All dogs were equipped with strain gauge force transducers on the ileocolon for measurement of the colonic contractile activity. RESULTS: Intravenous CGRP evoked GMCs and defecation in the neurally intact group; these stimulatory effects were inhibited by atropine and hexamethonium. Compared with the neurally intact group, the T/R group exhibited similar proximal colonic motility and decreased distal colonic motility after intravenous CGRP administration, whereas the extrinsic denervation group exhibited increased colonic motility overall. CONCLUSIONS: Intravenous CGRP induces colonic motility and defecation through acetylcholine release in conscious dogs. The continuity of the enteric nerves plays an important role in CGRP-induced colonic contractions and defecation, while the extrinsic nerves suppress CGRP-induced colonic motility.

  1226. 肝Reactive lymphoid hyperplasia3例の臨床病理組織学的検討

    熊田 博之, 松村 宗幸, 清水 健司, 中西 渉, 戸子台 和哲, 中西 史, 宮城 重人, 海野 倫明, 亀井 尚

    日本消化器外科学会雑誌　51　(Suppl.2)　182-182　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1227. Cytoprotective Effects of Mesenchymal Stem Cells During Liver Transplantation from Donors After Cardiac Death in Rats

    H. Sasajima, S. Miyagi, Y. Kakizaki, T. Kamei, M. Unno, S. Satomi, M. Goto

    Transplantation Proceedings　50　(9)　2815-2820　2018/11/01

    Publisher: Elsevier USA

    DOI： 10.1016/j.transproceed.2018.02.180 　

    ISSN： 1873-2623 0041-1345

  1228. 大腸癌合併潰瘍性大腸炎の発生部位別の検討

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　357-357　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1229. Stage IV大腸癌に対する原発巣切除の意義

    大沼 忍, 唐澤 秀明, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　289-289　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1230. 回腸嚢炎治療における経口第三世代セフェム系抗菌薬の使用経験と考察

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 武者 宏昭, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　359-359　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1231. クローン病に対する新吻合法(Anti-mesenteric cutback end-to-side isoperistaltic anastomosis)は再手術率を低下させる可能性がある

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 青木 豪, 井本 博文, 山村 明寛, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　359-359　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1232. 新たに定義されたIntrahepatic cholangiocarcinoma with ductal plate malformationが疑われた一例

    海野 裕一郎, 伊関 雅裕, 水間 正道, 畠 達夫, 高館 達之, 有明 恭平, 石田 晶玄, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 藤島 史善, 古川 徹, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　183-183　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1233. 腹腔鏡下膵手術により得られた膵周囲の膜解剖 膵体尾部を中心に

    森川 孝則, 石田 晶玄, 高舘 達之, 青木 豪, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　385-385　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1234. 後期高齢者膵癌における外科治療の特徴と術前治療の有用性

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    日本消化器外科学会雑誌　51　(Suppl.2)　376-376　2018/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1235. 生体部分肝移植ドナー手術における低侵襲化の試み 上腹部正中切開での右葉グラフト摘出

    福岡 健吾, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 熊田 博之, 海野 倫明

    肝臓　59　(Suppl.3)　A926-A926　2018/11

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  1236. Arterial Complication After Simultaneous Pancreas-Kidney Transplantation From an Abdominal Aortic Aneurysm Donor: A Case Report

    K. Shimizu, S. Miyagi, K. Maida, W. Nakanishi, Y. Hara, K. Tokodai, C. Nakanishi, Y. Umeda, S. Satomi, M. Goto, M. Unno, T. Kamei

    Transplantation Proceedings　50　2891-2894　2018/11/01

    DOI： 10.1016/j.transproceed.2018.02.188 　

    ISSN： 0041-1345

  1237. Correlation Between Splenectomy and Portal Vein Complications in Living Donor Liver Transplantation

    S. Miyagi, C. Nakanishi, Y. Hara, W. Nakanishi, K. Tokodai, K. Shimizu, S. Uematsu, H. Kumata, Y. Kakizaki, M. Goto, T. Kamei, M. Unno, S. Satomi

    Transplantation Proceedings　50　2611-2613　2018/11/01

    DOI： 10.1016/j.transproceed.2018.03.104 　

    ISSN： 0041-1345

  1238. Effect of Middle Hepatic Vein Tributaries Preserving Technique Until Just Before Graft Retrieval on Donors’ Surgical Outcomes in Living Donor Liver Transplantation

    K. Miyazawa, S. Miyagi, C. Nakanishi, Y. Hara, K. Tokodai, K. Tokodai, W. Nakanishi, S. Uematsu, K. Shimizu, M. Goto, T. Kamei, M. Unno

    Transplantation Proceedings　50　(9)　2636-2639　2018/11/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.transproceed.2018.03.092 　

    ISSN： 0041-1345

  1239. 広汎子宮全摘・骨盤リンパ節郭清術後に生じた尿管による絞扼性腸閉塞の1例

    小林 実, 大沼 忍, 村上 恵, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 武者 宏昭, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　38　(7)　1149-1152　2018/11

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1240. Outcomes of 1,639 hepatectomies for non-colorectal non-neuroendocrine liver metastases: a multicenter analysis. Peer-reviewed

    Keiji Sano, Masakazu Yamamoto, Tetsushige Mimura, Itaru Endo, Shoji Nakamori, Masaru Konishi, Masaru Miyazaki, Toshifumi Wakai, Masato Nagino, Keiichi Kubota, Michiaki Unno, Naohiro Sata, Junji Yamamoto, Hiroki Yamaue, Tadahiro Takada

    Journal of hepato-biliary-pancreatic sciences　25　(11)　465-475　2018/11

    DOI： 10.1002/jhbp.587 　

    ISSN： 1868-6974

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    BACKGROUND: Whether non-colorectal non-neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear. METHODS: Data regarding 1,639 hepatectomies performed between 2001 and 2010 for 1,539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post-hepatectomy outcomes were analyzed. RESULTS: The five most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%]). R0/1 hepatectomy was achieved in 90% of patients, with 1.5% in-hospital mortality rate. Overall and disease-free survival rates of 1,465 patients included in survival analysis were 41% and 21%, respectively, at 5 years, and 28% and 15%, respectively, at 10 years. Five-year survival associated with the five frequent primary tumors were 32%, 72%, 17%, 52%, and 31%, respectively, and factors predictive of a poor outcome differed by the primary tumor type. CONCLUSIONS: Our data indicated that hepatectomy is safe for NCNNLM and that patient prognoses vary depending on the type of primary tumors. Indications for hepatectomy should be determined with reference to survival rates and risk factors specific to each of the various types of primary tumor.

  1241. Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms. International-journal Peer-reviewed

    Hiroyuki Kumata, Keigo Murakami, Kazuyuki Ishida, Shigehito Miyagi, Atsushi Arakawa, Yoshiaki Inayama, Keiichi Kinowaki, Atsushi Ochiai, Motohiro Kojima, Michiyo Higashi, Suzuko Moritani, Kyoko Kuwahara, Yukio Nakatani, Dai Kajiura, Gen Tamura, Hiroshi Kijima, Mitsunori Yamakawa, Taizo Shiraishi, Yukinori Inadome, Kazuhiro Murakami, Hiroyoshi Suzuki, Takashi Sawai, Michiaki Unno, Takashi Kamei, Hironobu Sasano

    Hepatology research : the official journal of the Japan Society of Hepatology　48　(12)　989-999　2018/11

    DOI： 10.1111/hepr.13201 　

    ISSN： 1386-6346

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    STEROIDOGENESIS IN HEPATIC MUCINOUS CYSTIC NEOPLASM: Aim Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. Mucinous cystic neoplasms are known to harbor ovarian-like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs. Methods Both steroid receptors and steroidogenic factors were immunohistochemically evaluated using H-scores and results were compared with those in 15 ovarian MCNs and 10 normal ovaries. Results Androgen receptor (AR) H-scores in OLS were significantly higher in hepatic, pancreatic, and ovarian MCN than those in normal ovaries. H-scores of cytochrome P450 17α-hydroxylase/c17-20 lyase (P450c17) and 5α-reductase-1 (5αRED-1) in the stroma were significantly higher in OLS of hepatic and pancreatic MCN than in the stroma of ovarian MCN and normal ovary. In tumor epithelium, AR H-scores were significantly higher in hepatic and pancreatic MCN than in ovarian MCN. In both hepatic and pancreatic MCN, a significant positive correlation was detected between AR H-score in the epithelium and P450c17 H-score in OLS (hepatic MCN: Pearson's r = 0.446, P = 0.025; pancreatic MCN: r = 0.432, P = 0.035). In pancreatic MCN, a significantly positive correlation was detected between AR H-score in the tumor epithelium and 5αRED-1 H-score in OLS (Pearson's r = 0.458, P = 0.024). Conclusions These results indicated that locally produced androgens in OLS could be pivotal for tumorigenesis of both hepatic and pancreatic MCN and influence epithelial cells, possibly in a paracrine fashion, which could represent biological significance of OLS in these neoplasms.

  1242. 膵神経内分泌腫瘍の治療戦略 膵神経内分泌腫瘍における肝転移リスク因子の検討

    志村 充広, 水間 正道, 海野 倫明

    日本消化器病学会雑誌　115　(臨増大会)　A637-A637　2018/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1243. 【あたらしい外科局所解剖全図-ランドマークとその出し方】肝胆膵 Special Lecture 尾状葉門脈枝のバリエーション

    益田 邦洋, 中川 圭, 青木 修一, 海野 倫明

    臨床外科　73　(11)　212-218　2018/10

    Publisher: (株)医学書院

    ISSN： 0386-9857

  1244. 分子生物学から臨床への還元 胃の主細胞に幹細胞が存在し胃癌の起源となりうる

    山村 明寛, 伊藤 嘉明, 海野 倫明

    日本消化器病学会雑誌　115　(臨増大会)　A615-A615　2018/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1245. 進行胆嚢癌の術式選択と治療成績:いかにして根治を得るか? 胆嚢癌切除成績の検討からみた術前予後因子抽出の重要性

    中川 圭, 高舘 達之, 水間 正道, 大塚 英郎, 益田 邦洋, 伊関 雅裕, 有明 恭平, 川口 桂, 石田 晶玄, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　297-297　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1246. Borderline resectable膵癌の治療戦略と成績 BR/UR-LA膵癌に対する外科治療戦略 Neoadjuvantか? Conversionか?

    元井 冬彦, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　355-355　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1247. 局所進行切除不能膵癌conversion surgeryの成績:安全性と予後の評価 局所進行切除不能膵癌に対する治療戦略

    林 洋毅, 元井 冬彦, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　368-368　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1248. 大腸癌肝転移術後早期再発予測因子の検討

    伊関 雅裕, 中川 圭, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　474-474　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1249. 安全性と定型化を意識した高難度腹腔鏡下膵切除術

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 川口 桂, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　506-506　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1250. 多発肝転移、リンパ節転移を認めた非機能性十二指腸神経内分泌腫瘍G1の一例

    小山 慧, 伊関 雅裕, 水間 正道, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 藤島 史喜, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　857-857　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1251. 肝門部領域胆管癌において腹腔洗浄細胞診を検討する意義はあるか

    中川 圭, 益田 邦洋, 伊関 雅裕, 高舘 達之, 畠 達夫, 有明 恭平, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　PS-5　2018/10

    Publisher: (一社)日本癌治療学会

  1252. 肝細胞移植における至適移植部位の検討

    小笠原 弘之, 稲垣 明子, 猪村 武弘, 齋藤 純健, 松村 宗幸, 福岡 健吾, Fathi Ibrahim, 宮城 重人, 大橋 一夫, 海野 倫明, 亀井 尚, 後藤 昌史

    Organ Biology　25　(3)　67-67　2018/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1253. 膵島との共移植が肝細胞生着へ及ぼす影響に関する検討

    齋藤 純健, 稲垣 明子, 猪村 武弘, 猪村 梢, Fathi Ibrahim, 小笠原 弘之, 宮城 重人, 亀井 尚, 海野 倫明, 安波 洋一, 後藤 昌史

    Organ Biology　25　(3)　68-68　2018/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1254. ドナー膵の細胞外マトリックス組成に対応する膵島分離の実現に向けた試み

    宮崎 勇希, 猪村 武弘, 村山 和隆, 稲垣 明子, 宮城 重人, 島 弘季, 五十嵐 和彦, 海野 倫明, 亀井 尚, 後藤 昌史

    Organ Biology　25　(3)　94-94　2018/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1255. 【胆道癌の薬物療法:Up-to-Date】切除可能胆道癌に対する術前補助療法 Peer-reviewed

    中川 圭, 益田 邦洋, 伊関 雅裕, 高舘 達之, 元井 冬彦, 海野 倫明

    胆と膵　39　(10)　881-885　2018/10

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1256. Lymph nodes around the posterior gastric artery: their existence, frequency, and clinical implications. Peer-reviewed

    Kentaro Ishii, Masaharu Ishida, Norihiko Sugisawa, Megumi Murakami, Tomoyuki Ono, Tomoyoshi Tachibana, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Shinobu Ohnuma, Naoaki Sakata, Hiroaki Musha, Takanori Morikawa, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　48　(10)　916-920　2018/10

    DOI： 10.1007/s00595-018-1677-0 　

    ISSN： 0941-1291

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    PURPOSE: The lymphatic flow along the posterior gastric artery (PGA) is considered of possible clinical importance in terms of lymphatic metastasis; however, little is known about the lymph nodes (LNs) around this artery. The purpose of this study was to establish if LNs exist around the PGA and to evaluate their clinical implications. METHODS: We examined the tissues surrounding the PGA from 21 cadavers to search for LNs. We also investigated the patterns of lymphatic metastases in patients who underwent surgery for gastric neoplasms at our institute to detect their presence along the PGA. RESULTS: The PGA was identified in 11 cadavers, and LNs around the PGA were detected microscopically in 2 of these. Lymphatic metastasis directly to the LNs at the splenic artery without any metastases was regarded as skip metastasis along the PGA. Skip metastasis was found in two of ten patients who underwent surgery for remnant gastric cancer. CONCLUSIONS: The existence of LNs around the PGA was confirmed, and based on our findings, lymphatic metastasis through the PGA is possible in patients with remnant gastric cancer.

  1257. Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Michael Bouvet, Shree Ram Singh, Michiaki Unno, Robert M Hoffman

    Cancer letters　432　251-259　2018/09/28

    Publisher: Elsevier Ireland Ltd

    DOI： 10.1016/j.canlet.2018.06.016 　

    ISSN： 1872-7980 0304-3835

  1258. Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma. International-journal Peer-reviewed

    Kei Kawaguchi, Takashi Higuchi, Shukuan Li, Qinghong Han, Yuying Tan, Kentaro Igarashi, Ming Zhao, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Hiromichi Ohshiro, Norihiko Sugisawa, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Mark A Eckardt, Arun S Singh, Shree Ram Singh, Fritz C Eilber, Michiaki Unno, Robert M Hoffman

    Biochemical and biophysical research communications　503　(4)　3086-3092　2018/09/18

    DOI： 10.1016/j.bbrc.2018.08.097 　

    ISSN： 0006-291X

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    Melanoma is a recalcitrant cancer. To improve and individualize treatment for this disease, we previously developed a patient-derived orthotopic xenograft (PDOX) model for melanoma. We previously reported the individual efficacy of tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) and recombinant methioninase (rMETase) for melanoma in the PDOX models of this disease. In the present study, we evaluated the efficacy of the combination of S. typhimurium A1-R with orally-administered rMETase (o-rMETase) for BRAF-V600E-negative melanoma in a PDOX model. Three weeks after implantation, 60 PDOX mouse models were randomized into six groups of 10 mice each: untreated control, temozolomide (TEM); o-rMETase; S. typhimurium A1-R; TEM + rMETase, S. typhimurium A1-R + rMETase. All treatments inhibited tumor growth compared to untreated control (TEM: p < 0.0001, rMETase: p < 0.0001, S. typhimurium A1-R: p < 0.0001, TEM + rMETase: p < 0.0001, S. typhimurium A1-R + rMETase: p < 0.0001). The most effective was the combination of S. typhimurium A1-R + o-rMETase which regressed this melanoma PDOX, thereby indicating a new paradigm for treatment of metastatic melanoma.

  1259. Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report. International-journal Peer-reviewed

    Hiroyuki Kumata, Ryuichi Nishimura, Chikashi Nakanishi, Chihiro Inoue, Yuta Tezuka, Hidenori Endo, Shigehito Miyagi, Teiji Tominaga, Michiaki Unno, Takashi Kamei

    Surgical case reports　4　(1)　119-119　2018/09/17

    DOI： 10.1186/s40792-018-0529-x 　

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    BACKGROUND: Ganglioneuroblastomas, particularly those that produce catecholamine, are extremely rare in adults. Here, we report an interesting surgical case of an adult patient with a catecholamine-producing ganglioneuroblastomas in her adrenal gland, suspected to be a pheochromocytoma, and with a cerebral aneurysm. CASE PRESENTATION: The patient was a 73-year-old woman under treatment for hypertension. During a health check-up, a cystic retroperitoneal tumor was incidentally found in the superior pole of her right kidney. Her blood adrenaline level was slightly elevated, and her urinary adrenaline, noradrenaline, and dopamine levels were above the upper reference limits. In addition, 24-h urinary excretion of metanephrine, normetanephrine, and vanillylmandelic acid were all increased. 123I-Meta-iodobenzylguanidine scintigraphy showed an abnormal accumulation of the marker in the cyst wall. She was, therefore, diagnosed with a pheochromocytoma and scheduled for tumor resection. However, preoperatively, 8-mm-diameter cerebral aneurysm was incidentally found in her basilar artery. This required careful preoperative discussion. The aneurysm was difficult to approach and treat, and based on its position, shape, and size, the risk of rupture was low. Because hypertension is a major risk factor for aneurysmal rupture, we decided to proceed with the tumor resection. A lumbar catheter was placed to monitor the cerebral aneurysm for intraoperative rupture, and her transcranial motor-evoked potential and somatosensory-evoked potentials were monitored to track her intraoperative neurological function. During surgery, we carefully monitored fluctuations in blood pressure and resected the tumor with minimal mobilization. Postoperatively, head computed tomography confirmed that there was no sign of rupture. Histopathologically, the tumor was diagnosed as a catecholamine-producing ganglioneuroblastoma. The postoperative course was good, and the patient's blood pressure improved. CONCLUSIONS: Careful perioperative management is needed for a patient with both a catecholamine-producing tumor and cerebral aneurysm.

  1260. Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell. International-journal Peer-reviewed

    Norihiko Sugisawa, Shinobu Ohnuma, Hirofumi Ueda, Megumi Murakami, Kyoko Sugiyama, Kosuke Ohsawa, Kuniyuki Kano, Hidetoshi Tokuyama, Takayuki Doi, Junken Aoki, Masaharu Ishida, Katsuyoshi Kudoh, Takeshi Naitoh, Suresh V Ambudkar, Michiaki Unno

    Molecular pharmaceutics　15　(9)　4021-4030　2018/09/04

    DOI： 10.1021/acs.molpharmaceut.8b00457 　

    ISSN： 1543-8384

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    ATP-binding cassette (ABC) transporters, which are concerned with the efflux of anticancer drugs from cancer cells, have a pivotal role in multidrug resistance (MDR). In particular, ABCB1 is a well-known ABC transporter that develops MDR in many cancer cells. Some ABCB1 modulators can reverse ABCB1-mediated MDR; however, no modulators with clinical efficacy have been approved. The aim of this study was to identify novel ABCB1 modulators by using high-throughput screening. Of the 5861 compounds stored at Tohoku University, 13 compounds were selected after the primary screening via a fluorescent plate reader-based calcein acetoxymethylester (AM) efflux assay. These 13 compounds were validated in a flow cytometry-based calcein AM efflux assay. Two isoquinoline derivatives were identified as novel ABCB1 inhibitors, one of which was a phenethylisoquinoline alkaloid, (±)-7-benzyloxy-1-(3-benzyloxy-4-methoxyphenethyl)-1,2,3,4-tetrahydro-6-methoxy-2-methylisoquinoline oxalate. The compound, a phenethylisoquinoline alkaloid, was subsequently evaluated in the cytotoxicity assay and shown to significantly enhance the reversal of ABCB1-mediated MDR. In addition, the compound activated the ABCB1-mediated ATP hydrolysis and inhibited the photolabeling of ABCB1 with [125I]-iodoarylazidoprazosin. Furthermore, the compound also reversed the resistance to paclitaxel without increasing the toxicity in the ABCB1-overexpressing KB-V1 cell xenograft model. Overall, we concluded that the newly identified phenethylisoquinoline alkaloid reversed ABCB1-mediated MDR through direct interaction with the substrate-binding site of ABCB1. These findings may contribute to the development of more potent and less toxic ABCB1 modulators, which could overcome ABCB1-mediated MDR.

  1261. 【胆管癌の手術】 肝門部領域胆管癌に対する動脈再建を伴う拡大切除

    中川 圭, 宮城 重人, 深瀬 耕二, 益田 邦洋, 元井 冬彦, 海野 倫明

    手術　72　(10)　1491-1498　2018/09

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1262. 巨大後腹膜腫瘍切除後に椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症の1例

    三浦 孝之, 伊関 雅裕, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　84-84　2018/09

    Publisher: 日本Acute Care Surgery学会

    eISSN： 2436-102X

  1263. 胃癌におけるRunx3遺伝子のR122C変異は前癌病変の腸上皮化生を誘導する(Gastric cancer derived RUNX3 mutation, R122C, induces intestinal metaplasia-like lesion in the antrum of knock-in mouse)

    山村 明寛, 堂地 大輔, 松尾 純一, リムイーフイ・メリッサ, 河府 和義, ディディー・リアナヘン, ムハンマドザキール・ホサイン, 内藤 剛, 亀井 尚, 海野 倫明, 伊藤 嘉明

    日本癌学会総会記事　77回　1106-1106　2018/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  1264. 抗ドナーHLA抗体陽性の肝移植の短期・長期成績と問題点 肝移植後長期経過症例における抗ドナーHLA抗体陽性の意義

    戸子台 和哲, 宮城 重人, 中西 史, 中西 渉, 西村 隆一, 清水 健司, 福岡 健吾, 熊田 博之, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　53　(総会臨時)　256-256　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1265. 脳死肝摘出オールジャパン体制は是か否か 肝膵腎移植を同チームで施行する立場から

    宮城 重人, 中西 史, 戸子台 和哲, 原 康之, 中西 渉, 西村 隆一, 清水 健司, 熊田 博之, 福岡 健吾, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　53　(総会臨時)　261-261　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1266. 小児移植後長期経過例の諸問題 小児生体肝移植後成人移行症例の検討

    中西 史, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　53　(総会臨時)　286-286　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1267. 当施設における生体肝移植ドナーの術後長期フォロー

    西村 隆一, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 清水 健司, 福岡 健吾, 熊田 博之, 齋藤 尚子, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　53　(総会臨時)　405-405　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1268. 腎グラフトに生じた尿管癌に対して移植腎摘出した一例

    中西 渉, 宮城 重人, 中西 史, 戸子台 和哲, 西村 隆一, 清水 健司, 福岡 健吾, 熊田 博之, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　53　(総会臨時)　414-414　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1269. 抗ドナー血液型抗体価4096倍のABO血液型不適合生体肝移植を施行し良好な経過を得た1例

    齋藤 純健, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 清水 健司, 福岡 健吾, 熊田 博之, 松村 宗幸, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　53　(総会臨時)　449-449　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1270. 膵腎同時移植後合併症と対策

    宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　53　(総会臨時)　518-518　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1271. AOM/DSS炎症性発癌モデルにおけるインフリキシマブの大腸癌抑制効果(Infliximab inhibits colon carcinogenesis in AOM/DSS-induced colitic cancer mouse model)

    王 丹陽, 大沼 忍, 石居 健太郎, 村上 恵, 杉沢 徳彦, 唐澤 秀明, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本癌学会総会記事　77回　398-398　2018/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1272. 本邦の膵島移植の今後の展開 東北大学が目指す膵島移植の次の展開

    後藤 昌史, 稲垣 明子, 山形 洋平, 村山 和隆, 渡邉 君子, 前田 浩, 猪村 武弘, 五十嵐 康宏, 植松 智海, 宮崎 勇希, 水井 崇浩, Fathi Ibrahim, 戸子台 和哲, 宮城 重人, 藤盛 啓成, 亀井 尚, 海野 倫明

    移植　53　(総会臨時)　275-275　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1273. 膵島から放出される細胞生着促進因子を用いた肝細胞グラフトの成績向上について

    齋藤 純健, 猪村 武弘, 稲垣 明子, 後藤 めぐみ, Fathi Ibrahim, 小笠原 弘之, 宮城 重人, 亀井 尚, 海野 倫明, 安波 洋一, 後藤 昌史

    移植　53　(総会臨時)　514-514　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1274. 肝細胞移植の生着率向上をめざしたヘパリン及びアピラーゼ肝細胞表面コーティング法の最適化についての検討

    小笠原 弘之, 寺村 裕治, 稲垣 明子, 齋藤 純健, 松村 宗幸, Fathi Ibrahim, 宮城 重人, Nilsson Kristina, 大橋 一夫, 海野 倫明, 亀井 尚, Nilsson Bo, Gustafson Elisabet, 後藤 昌史

    移植　53　(総会臨時)　515-515　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1275. ドナー膵組織の細胞外マトリックス組成に対応する膵島分離酵素の至適化に向けた試み

    宮崎 勇希, 猪村 武弘, 村山 和隆, Fathi Ibrahim, 山形 洋平, 前田 浩, 渡邉 君子, 稲垣 明子, 宮城 重人, 島 弘季, 五十嵐 和彦, 海野 倫明, 亀井 尚, 後藤 昌史

    移植　53　(総会臨時)　523-523　2018/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1276. ここまで来た!膵癌の早期診断 膵癌の疫学:膵癌登録におけるT1膵癌の解析

    水間正道, 海野倫明, 五十嵐久人, 糸井隆夫, 江川新一, 児玉裕三, 里井壯平, 濱田晋, 水元一博, 下瀬川徹, 岡崎和一

    胆と膵　39　(9)　763-767　2018/09

    Publisher:

    ISSN： 0388-9408

  1277. 【胆管癌の手術】肝門部領域胆管癌に対する動脈再建を伴う拡大切除 Peer-reviewed

    中川 圭, 宮城 重人, 深瀬 耕二, 益田 邦洋, 元井 冬彦, 海野 倫明

    手術　72　(10)　1491-1498　2018/09

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1278. Clinical guidelines for primary sclerosing cholangitis 2017. Peer-reviewed

    Hiroyuki Isayama, Susumu Tazuma, Norihiro Kokudo, Atsushi Tanaka, Toshio Tsuyuguchi, Takahiro Nakazawa, Kenji Notohara, Suguru Mizuno, Nobuhisa Akamatsu, Masahiro Serikawa, Itaru Naitoh, Yoshiki Hirooka, Toshifumi Wakai, Takao Itoi, Tomoki Ebata, Shinji Okaniwa, Terumi Kamisawa, Hiroki Kawashima, Atsushi Kanno, Keiichi Kubota, Masami Tabata, Michiaki Unno, Hajime Takikawa

    Journal of gastroenterology　53　(9)　1006-1034　2018/09

    DOI： 10.1007/s00535-018-1484-9 　

    ISSN： 0944-1174

    More details Close

    BACKGROUND: Primary sclerosing cholangitis (PSC) is relatively rare disease and pathogenesis and methods of treatments were still not established. Then, we had conducted the making clinical guidelines to manage patients with PSC based on the literature review and expert opinions. These clinical guidelines were made for the medical doctors on the management of PSC, except child case of PSC. METHODS: We had employed modified Delphi method. The production committee decided guidelines, strength of recommendations and evidence level after reviewed literatures systematically, and The Expert panel evaluated those. The Scientific Committee of the Japan Biliary Association (JBA) evaluated revised guidelines, and the Public comments were collected on web site of JBA. RESULTS: We had made 16 guidelines about epidemiology/pathophysiology, diagnostics, therapy and prognosis. Also, we had made both diagnostic and therapeutic flow chart. CONCLUSIONS: We hope that these guidelines will contribute to the improvement and development of the medical care of PSC.

  1279. Surgical outcome of extra-hepatic cholangiocarcinoma

    Michiaki Unno, Kei Nakagawa, Hiroki Hayashi, Koji Fukase, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh

    Surgery, Gastroenterology and Oncology　23　(4)　278-283　2018/08/01

    Publisher: Celsius Publishing House

    DOI： 10.21614/sgo-23-4-278 　

    ISSN： 2601-1700 2559-723X

  1280. 【ここまで来た ナビゲーション手術】肝門部領域胆管癌に対する術前シミュレーションと術中応用

    益田 邦洋, 中川 圭, 伊関 雅裕, 高舘 達之, 元井 冬彦, 海野 倫明

    消化器外科　41　(9)　1305-1315　2018/08

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  1281. 【胆管内乳頭状腫瘍(IPNB)の病態と診療の現状】 胆管内乳頭状腫瘍(IPNB) 粘液産生の有無で区別する臨床的意義 Invited

    水間 正道, 青木 泰孝, 森川 孝則, 元井 冬彦, 古川 徹, 海野 倫明

    胆と膵　39　(8)　707-710　2018/08

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1282. 【ここまで来た ナビゲーション手術】 肝門部領域胆管癌に対する術前シミュレーションと術中応用

    益田 邦洋, 中川 圭, 伊関 雅裕, 高舘 達之, 元井 冬彦, 海野 倫明

    消化器外科　41　(9)　1305-1315　2018/08

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  1283. 【徹底解説! 膵尾側切除を極める】術式のポイント 腹腔動脈合併膵体尾部切除術(DP-CAR)の適応と手術手技

    元井 冬彦, 林 洋毅, 海野 倫明

    臨床外科　73　(8)　970-975　2018/08

    Publisher: (株)医学書院

    ISSN： 0386-9857

  1284. Classical Hodgkin lymphoma-type and monomorphic-type post-transplant lymphoproliferative disorder following liver transplantation: a case report. International-journal Peer-reviewed

    Hiroyuki Kumata, Chikashi Nakanishi, Keigo Murakami, Shigehito Miyagi, Noriko Fukuhara, Joaquim Carreras, Naoya Nakamura, Ryo Ichinohasama, Michiaki Unno, Takashi Kamei, Hironobu Sasano

    Surgical case reports　4　(1)　72-72　2018/07/06

    DOI： 10.1186/s40792-018-0480-x 　

    More details Close

    BACKGROUND: Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication that can be difficult to treat; moreover, determination of the pathophysiological type is difficult. We report a rare case of a patient who developed two types of Epstein-Barr virus (EBV)-negative PTLD following living donor liver transplantation (LDLT). CASE PRESENTATION: A 64-year-old man underwent LDLT for acute fulminant hepatitis B. Sixty-five months later, he developed EBV-negative monomorphic B cell PTLD. Reduction of immunosuppressive therapy and chemotherapy with rituximab resulted in a partial response. He received radioimmunotherapy with yttrium-90-ibritumomab tiuxetan, which was effective for all lesions, except for the splenic hilar lesion, which enlarged and seemed to penetrate the stomach. Therefore, he underwent resection of the pancreatic tail with splenectomy and partial gastrectomy. The pathological diagnosis was EBV-negative classical Hodgkin lymphoma (cHL)-type PTLD. CONCLUSIONS: This patient showed an unexpected course of PTLD, from both a clinical and pathological perspective. There are no prior reports of an adult case of EBV-negative cHL-type PTLD coexisting with EBV-negative monomorphic B cell PTLD. When a strange and refractory lesion persists despite effective therapy for PTLD, we must consider the possibility of another type of PTLD within the residual lesion.

  1285. The Risk Factors for Portal Vein Thrombosis After Living Donor Liver Transplantation in Adults Peer-reviewed

    Miyagi Shigehito, Nakanishi Chikashi, Hara Yasuyuki, Tokodai Kazuaki, Nakanishi Wataru, Nishimura Ryuichi, Shimizu Kenji, Uematsu Satomi, Kumata Hiroyuki, Kakizaki Yuta, Matsumura Muneyuki, Unno Michiaki, Satomi Susumu, Kamei Takashi, Goto Masafumi

    TRANSPLANTATION　102　S885　2018/07

    DOI： 10.1097/01.tp.0000543975.03568.bd 　

    ISSN： 0041-1337

  1286. 【胆膵】胆管癌に対する術前治療の意義 胆管癌に対する術前化学放射線療法の有用性とその適応

    中川 圭, 深瀬 耕二, 益田 邦洋, 伊関 雅裕, 高舘 達之, 大塚 英郎, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　68-68　2018/07

    Publisher: (一社)日本消化器外科学会

  1287. 【肝】肝内胆管癌の予後改善に向けた取り組み 腫瘤形成型肝内胆管癌に対するリンパ節郭清を伴う胆管切除の意義

    益田 邦洋, 中川 圭, 伊関 雅裕, 高舘 達之, 深瀬 耕二, 大塚 英郎, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　267-267　2018/07

    Publisher: (一社)日本消化器外科学会

  1288. 膵癌術前治療後の低骨格筋量は予後不良因子である

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　745-745　2018/07

    Publisher: (一社)日本消化器外科学会

  1289. 膵癌術前治療前後のPET SUVmax値の変化と組織学的治療効果の関係

    客本 ゆき恵, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　745-745　2018/07

    Publisher: (一社)日本消化器外科学会

  1290. 膵全摘後長期生存例の栄養状態の検討

    初沢 悠人, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　960-960　2018/07

    Publisher: (一社)日本消化器外科学会

  1291. Runx3変異は腸上皮化生を引き起こし胃癌の起源となる

    山村 明寛, 松尾 純一, 堂地 大輔, Lim Yi Hui Melissa, Dede Liana Heng, Hosain Md Zakir, 亀井 尚, 内藤 剛, 海野 倫明, 伊藤 嘉明

    日本消化器外科学会総会　73回　152-152　2018/07

    Publisher: (一社)日本消化器外科学会

  1292. 肝細胞と膵島の共移植による肝細胞生着の定量的及び組織学的検討

    齋藤 純健, 猪村 武弘, 稲垣 明子, Fathi Ibrahim, 小笠原 弘之, 宮城 重人, 亀井 尚, 海野 倫明, 安波 洋一, 後藤 昌史

    日本組織移植学会雑誌　17　(1)　48-48　2018/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  1293. 肝細胞移植における経門脈移植法と脾実質移植法の比較検討

    小笠原 弘之, 稲垣 明子, 猪村 武弘, 齋藤 純健, 松村 宗幸, 福岡 健吾, Fathi Ibrahim, 宮城 重人, 大橋 一夫, 海野 倫明, 亀井 尚, 後藤 昌史

    日本組織移植学会雑誌　17　(1)　49-49　2018/07

    Publisher: 日本組織移植学会

    ISSN： 1347-6491

  1294. Chronological Evaluation of Postoperative Nutritional Status and Quality of Life of Pancreatic Cancer Patients Peer-reviewed

    Sato N, Motoi F, Ariake K, Nakagawa K, Kawaguchi K, Sato M, Katayose Y, Sato F, Unno M

    Pancreas　47　(6)　783-784　2018/07

  1295. 【R0切除をめざした胆管癌の術前・術中・術後における診断・治療の工夫】胆道癌に対する術後補助療法の意義と適応 Peer-reviewed

    高舘 達之, 中川 圭, 益田 邦洋, 深瀬 耕二, 林 洋毅, 海野 倫明

    胆と膵　39　(7)　647-651　2018/07

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1296. 【R0切除をめざした胆管癌の術前・術中・術後における診断・治療の工夫】 胆道癌に対する術後補助療法の意義と適応

    高舘 達之, 中川 圭, 益田 邦洋, 深瀬 耕二, 林 洋毅, 海野 倫明

    胆と膵　39　(7)　647-651　2018/07

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1297. クローン病における直腸肛門管癌の癌スクリーニングの現状と問題点 国内専門施設へのアンケート調査

    渡辺 和宏, 倉地 清隆, 水島 恒和, 亀山 仁史, 佐々木 巌, 杉田 昭, 根津 理一郎, 舟山 裕士, 福島 浩平, 内藤 剛, 海野 倫明, 二見 喜太郎

    日本大腸肛門病学会雑誌　71　(7)　283-290　2018/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1298. 【最新版 "腸閉塞"を極める!】疾患別 診断と治療 慢性偽性腸閉塞症

    渡辺 和宏, 内藤 剛, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明

    臨床外科　73　(7)　830-834　2018/07

    Publisher: (株)医学書院

    ISSN： 0386-9857

  1299. 臨床研究成果の国際的発信"Surgery Today"の役割

    海野 倫明

    日本外科学会雑誌　119　(4)　438-440　2018/07

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1300. 【消化器癌に対する最新の集学的治療戦略】 転移性肝腫瘍の集学的治療戦略

    中川 圭, 伊関 雅裕, 有明 恭平, 元井 冬彦, 海野 倫明

    外科　80　(8)　844-850　2018/07

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  1301. Postoperative hepatolithiasis in pancreaticobiliary maljunction and congenital biliary dilatation

    Hideo Ohtsuka, Michiaki Unno

    Pancreaticobiliary Maljunction and Congenital Biliary Dilatation　243-252　2018/06/05

    Publisher: Springer Singapore

    DOI： 10.1007/978-981-10-8654-0_29 　

  1302. 膵切除術後の残膵における再発膵癌の切除術は臨床的に有望である 日本肝胆膵外科学会による膵臓手術に関するプロジェクト研究の結果(Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery)

    Yamada Suguru, Izumo Wataru, Kobayashi Akira, Miyagawa Shinichi, Nakamori Shoji, Hashimoto Daisuke, Baba Hideo, Shiozaki Shigehiro, Shima Yasuo, Maeda Shimpei, Unno Michiaki, Sato Naoya, Kenjo Akira, Natsume Seiji, Shimizu Yasuhiro, Hiyoshi Masahide, Nanashima Atsushi, Satoi Sohei, Okada Ken-ichi, Murata Yasuhiro, Murotani Kenta, Isaji Shuji, Nakamura Masafumi, Hirano Satoshi, Murakami Yoshiaki, Kodera Yasuhiro, Miyazaki Masaru, Yamamoto Masakazu, Yamaue Hiroki, 名古屋大学

    日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　229-229　2018/06

    Publisher: (一社)日本肝胆膵外科学会

  1303. 【胆膵疾患と性差医学】性差による臨床像の差異 胆管内乳頭状腫瘍

    窪田 敬一, 松本 尊嗣, 青木 琢, 中沼 安二, 乾 和郎, 海野 倫明

    胆と膵　39　(6)　509-514　2018/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1304. Effects of Subnormothermic Perfusion Before Transplantation for Liver Grafts from Donation After Cardiac Death: A Simplified Dripping Perfusion Method in Pigs. Peer-reviewed

    Kakizaki Y, Miyagi S, Shimizu K, Kumata H, Matsumura M, Miyazaki Y, Fukuoka K, Uematsu SS, Tokodai K, Hara Y, Nakanishi C, Unno M, Kamei T, Goto M

    Transplantation Proceedings　50　(5)　1538-1548　2018/06

  1305. 【胆膵疾患と性差医学】 性差による臨床像の差異 胆管内乳頭状腫瘍

    窪田 敬一, 松本 尊嗣, 青木 琢, 中沼 安二, 乾 和郎, 海野 倫明

    胆と膵　39　(6)　509-514　2018/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1306. Increased Bile Acid Signals After Duodenal-Jejunal Bypass Improve Non-alcoholic Steatohepatitis (NASH) in a Rodent Model of Diet-Induced NASH. International-journal Peer-reviewed

    Takahiro Tsuchiya, Takeshi Naitoh, Munenori Nagao, Naoki Tanaka, Kazuhiro Watanabe, Hirofumi Imoto, Tomohiro Miyachi, Fuyuhiko Motoi, Michiaki Unno

    Obesity surgery　28　(6)　1643-1652　2018/06

    DOI： 10.1007/s11695-017-3065-z 　

    ISSN： 0960-8923

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    BACKGROUND: The increasing incidence of non-alcoholic steatohepatitis (NASH) has resulted in it becoming a common cause of liver-related mortality; however, no efficient treatment has been established. It has been reported that bariatric surgery improves metabolic comorbidities, such as diabetes mellitus and NASH. Although the mechanism is unclear, it is thought that the changes in bile acid (BA) signaling via its nuclear receptor, farnesoid X receptor (FXR), produce various metabolic effects. We sought to investigate the effects and mechanisms of bariatric surgery on NASH improvement. METHODS: Male Sprague-Dawley rats were fed by a high-fat and high-fructose diet, which results in obesity, insulin resistance, and NASH. Rats underwent duodenal-jejunal bypass (DJB), which is a main component of bariatric procedures. The liver pathological findings and the expression level of mRNA of FXR were investigated. The plasma BA level was measured in peripheral and portal vein blood. RESULTS: DJB suppressed weight gain, improved insulin resistance, and ameliorated NASH mainly in a point of inflammation. The plasma BA level along with the expression of FXR and its target transcriptional factor, small heterodimer partner (SHP), in the liver were elevated. CONCLUSIONS: DJB has a direct effect on NASH improvement, and there is a possibility that an anti-inflammatory effect is functioning as a part of the mechanism. The increase of plasma bile acid level followed by the stimulation of FXR signaling may contribute to this phenomenon.

  1307. MEK inhibitor trametinib in combination with gemcitabine regresses a patient-derived orthotopic xenograft (PDOX) pancreatic cancer nude mouse model. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Thinzar M Lwin, Masuyo Miyake, Tasuku Kiyuna, Ho Kyoung Hwang, Takashi Murakami, Jonathan C Delong, Shree Ram Singh, Bryan Clary, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Tissue & cell　52　124-128　2018/06

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.tice.2018.05.003 　

    ISSN： 1532-3072 0040-8166

  1308. A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis. International-journal Peer-reviewed

    Mitsuhiro Shimura, Masamichi Mizuma, Tatsuyuki Takadate, Yasutake Katoh, Takashi Suzuki, Masahiro Iseki, Tatsuo Hata, Shuichi Aoki, Yukie Suzuki, Naoaki Sakata, Hideo Ohtsuka, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Hironobu Sasano, Michiaki Unno

    Oncotarget　9　(36)　24291-24303　2018/05/11

    DOI： 10.18632/oncotarget.25110 　

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    The aim of this study was to identify novel liver metastasis-correlated proteins of PanNEN by proteomics to compare pancreatic tumor (PT) with paired metastatic liver tumor (LT). Of 118 surgical cases with PanNEN, 7 cases with formalin-fixed paraffin-embedded (FFPE) tissues of both PT and paired LT were evaluated by proteomics. Tumor cells were selectively collected from FFPE tissues by laser capture microdissection. A total of 3,722 proteins were detected from extracted peptides by mass spectrometry-based shotgun analysis. Selection of the candidate proteins expressed differently between PT and LT were performed by semi-quantitative comparison in silico and confirmation with immunohistochemistry. We focused on ANXA6, CNPY2, RAB11B and TUBB3, all of which had higher expressions in LT. In all surgical cases with FFPE samples, liver recurrence-free survival (RFS) was evaluated in correlation to the expression of the candidate proteins in PT by immunohistochemistry. Liver RFS was significantly poorer in CNPY2 positive patients than in negative patients (10-year liver RFS; 39.8% vs. 92.3%, p = 0.012). Also, liver RFS tended to be poorer in ANXA6 positive patients than in those who were negative (10-year liver RFS; 51.4% vs. 95.0%, p = 0.099). In the multivariate analysis, the independent predictors of liver RFS were CNPY2 positivity (HR: 6.19, 95 % CI: 1.47-42.79, p = 0.011) and tumor size ≥ 42 mm (HR: 4.63, 95 % CI: 1.03-23.23, p = 0.045). In conclusion, CNPY2 is a novel liver metastasis-correlated protein of PanNEN.

  1309. プロテオミクス解析により発見した膵神経内分泌腫瘍の新規肝転移関連因子

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 青木 豪, 深瀬 耕二, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    膵臓　33　(3)　370-370　2018/05

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1310. 【敗血症・院内感染にいかに挑むか】 待機的肝胆膵術後敗血症の術前リスク因子解析および予後の検討

    片寄 友, 伊勢 一郎, 林 洋毅, 中川 圭, 森川 孝則, 水間 正道, 大塚 英郎, 武藤 満完, 徳村 弘実, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　38　(4)　635-641　2018/05

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1311. 【肝胆膵疾患のエピジェネティクスを学ぶ】 膵疾患のエピジェネティクス 膵IPMNのメチル化解析と診断への応用

    畠 達夫, 水間 正道, 元井 冬彦, 海野 倫明, Goggins Michael

    肝・胆・膵　76　(5)　939-944　2018/05

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1312. 【胆道・膵疾患術後の晩期障害】慢性膵炎に対するFrey手術後の再燃・発癌

    江川 新一, 石田 晶玄, 元井 冬彦, 海野 倫明

    胆と膵　39　(5)　491-494　2018/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1313. 【胆道・膵疾患術後の晩期障害】膵・胆管合流異常、先天性胆道拡張症分流手術後の胆道癌

    大塚 英郎, 水間 正道, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    胆と膵　39　(5)　459-465　2018/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1314. 【膵癌update】 治療 膵癌に対する術前補助療法

    元井 冬彦, 海野 倫明

    臨床消化器内科　33　(7)　831-837　2018/05

    Publisher: (株)日本メディカルセンター

    DOI： 10.19020/CG.0000000399 　

    ISSN： 0911-601X

  1315. 【膵癌に挑む】 切除可能膵癌に対する術前治療

    高舘 達之, 水間 正道, 元井 冬彦, 海野 倫明

    消化器外科　41　(6)　885-888　2018/05

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  1316. Association of post-transplant donor-specific HLA antibody with liver graft fibrosis during long-term follow-up after pediatric liver transplantation. International-journal Peer-reviewed

    Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Koji Miyazawa, Kenji Shimizu, Keigo Murakami, Hironobu Sasano, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Pediatric transplantation　22　(3)　e13169　2018/05

    Publisher: Blackwell Publishing Inc.

    DOI： 10.1111/petr.13169 　

    ISSN： 1399-3046 1397-3142

  1317. Clinical impact of developing better practices at the institutional level on surgical outcomes after distal pancreatectomy in 1515 patients: Domestic audit of the Japanese Society of Pancreatic Surgery. Peer-reviewed

    Sohei Satoi, Tomohisa Yamamoto, Fuyuhiko Motoi, Ippei Matsumoto, Hideyuki Yoshitomi, Ryosuke Amano, Munenori Tahara, Yoshiaki Murakami, Hidehito Arimitsu, Seiko Hirono, Masayuki Sho, Hironori Ryota, Masayuki Ohtsuka, Michiaki Unno, Yoshifumi Takeyama, Hiroki Yamaue

    Annals of gastroenterological surgery　2　(3)　212-219　2018/05

    DOI： 10.1002/ags3.12066 　

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    Background and Aim: Institutional standardization in the perioperative management of distal pancreatectomy (DP) has not been evaluated in a multicenter setting. The aim of the present study was to assess the influence of institutional standardization on the development of postoperative complications after DP. Methods: Data were collected from 1515 patients who underwent DP in 2006, 2010, and 2014 at 53 institutions in Japan. A standardized institution (SI) was defined as one that implemented ≥6 of 11 quality initiatives according to departmental policy. There were 541 patients in the SI group and 974 in the non-SI group. Clinical parameters were compared between groups. Risk factors for morbidity and mortality were assessed by logistic regression analysis with a mixed-effects model. Results: Proportion of patients who underwent DP in SI increased from 16.5% in 2006 to 46.4% in 2014. The SI group experienced an improved process of care and a lower frequency of severe complications vs the non-SI group (grade III/IV Clavien-Dindo; 22% vs 29%, respectively, clinically relevant postoperative pancreatic fistula; 22% vs 31%, respectively, P < .05 for both). Duration of in-hospital stay in the SI group was significantly shorter than that in the non-SI group (16 [5-183] vs 20 postoperative days [5-204], respectively; P = .002). Multivariate analysis with a mixed-effects model showed that soft pancreas, late drain removal, excess blood loss and long surgical time were risk factors for post-DP complications (P < .05). Pancreatic texture, drain management and surgical factors, but not standardization of care, were associated with a lower incidence of post-DP complications.

  1318. 膵手術と短期成績 膵管空腸側側吻合術(Lateral pancreatico-jejunostomy)

    石田 晶玄, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 大沼 忍, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　382-382　2018/04

    Publisher: (一社)日本外科学会

  1319. IPMNとIPNB-診断と治療のアップデート- 新分類(type1、type2)による胆管内乳頭状腫瘍(IPNB)切除例の検討

    水間 正道, 青木 泰孝, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 古川 徹, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　560-560　2018/04

    Publisher: (一社)日本外科学会

  1320. Border line膵癌に対する腹腔動脈合併尾側膵切除術(DP-CAR)の意義 腹腔動脈接触角度と術前治療有無からみた、当科DP-CAR症例の予後の検討

    林 洋毅, 元井 冬彦, 水間 正道, 有明 恭平, 畠 達夫, 高舘 達之, 伊関 雅裕, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　607-607　2018/04

    Publisher: (一社)日本外科学会

  1321. 安全に配慮した高難度腹腔鏡下膵切除 Referee systemを用いた安全な腹腔鏡下膵頭十二指腸切除術の導入

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 大沼 忍, 深瀬 耕二, 大塚 英郎, 水間 正道, 武者 宏昭, 中川 圭, 林 洋毅, 宮城 重人, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　686-686　2018/04

    Publisher: (一社)日本外科学会

  1322. 進行胆嚢癌に対する集学的治療と新たな治療 進行胆嚢癌の治療成績から見た手術適応と治療戦略

    益田 邦洋, 林 洋毅, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　696-696　2018/04

    Publisher: (一社)日本外科学会

  1323. 肝再生におけるMuse細胞移植の可能性

    伊関 雅裕, 水間 正道, 深瀬 正彦, 小野 智之, 志村 充宏, 鈴木 ゆき恵, 伊勢 一郎, 石田 晶玄, 工藤 克昌, 林 洋毅, 元井 冬彦, 若尾 昌平, 串田 良祐, 亀井 尚, 石田 孝宣, 内藤 剛, 出澤 真理, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1249-1249　2018/04

    Publisher: (一社)日本外科学会

  1324. 重症急性胆嚢炎の治療戦略

    大塚 英郎, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1691-1691　2018/04

    Publisher: (一社)日本外科学会

  1325. 肝門部領域胆管癌における腹腔洗浄細胞診の意義

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 畠 達夫, 有明 恭平, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2032-2032　2018/04

    Publisher: (一社)日本外科学会

  1326. 術後合併症予防・早期回復のための周術期管理の工夫 当科におけるEnhanced Recovery After Surgeryの原発性肝癌に対する肝切除における効果についての検討

    中西 渉, 宮城 重人, 中西 史, 戸子台 和哲, 原 康之, 宮澤 恒持, 清水 健司, 植松 智海, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　394-394　2018/04

    Publisher: (一社)日本外科学会

  1327. 小児肝移植後ドナー特異的抗HLA抗体と肝線維化の関連

    戸子台 和哲, 宮城 重人, 中西 史, 原 康之, 中西 渉, 宮澤 恒持, 植松 智海, 清水 健司, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1076-1076　2018/04

    Publisher: (一社)日本外科学会

  1328. 膵頭十二指腸切除における動脈合併切除再建の安全性と当科における工夫

    宮城 重人, 中西 史, 原 康之, 中西 渉, 戸子台 和哲, 宮澤 恒持, 清水 健司, 植松 智海, 森川 孝則, 元井 冬彦, 石田 孝宣, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1367-1367　2018/04

    Publisher: (一社)日本外科学会

  1329. 再建困難例に対する肝移植の工夫 特に動脈再建について

    宮城 重人, 亀井 尚, 海野 倫明

    肝臓　59　(Suppl.1)　A534-A534　2018/04

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  1330. Barrett食道癌に対するリンパ節郭清範囲と術式の検討

    郷右近 祐介, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 丸山 祥太, 岡本 宏史, 石田 裕嵩, 小野寺 優, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1098-1098　2018/04

    Publisher: (一社)日本外科学会

  1331. 食道胃接合部癌の縦隔リンパ節至適郭清範囲に対する検討

    瓶子 隆弘, 小野寺 優, 石田 裕嵩, 丸山 祥太, 櫻井 直, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1961-1961　2018/04

    Publisher: (一社)日本外科学会

  1332. cT4食道癌に対する化学放射線治療後の外科手術の治療成績

    小野寺 優, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 丸山 祥太, 石田 裕嵩, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　2324-2324　2018/04

    Publisher: (一社)日本外科学会

  1333. 膵頭十二指腸切除術における周術期管理標準化は術後合併症に影響を与えるか? 日本膵切研究会アンケート調査結果報告 Peer-reviewed

    里井 壯平, 山本 智久, 吉富 秀幸, 元井 冬彦, 廣野 誠子, 藤井 努, 和田 慶太, 有光 秀仁, 庄 雅之, 松本 逸平, 平野 聡, 柳本 泰明, 大塚 将之, 海野 倫明, 山上 裕機, 權 雅憲

    日本外科学会定期学術集会抄録集　118回　1285-1285　2018/04

    Publisher: (一社)日本外科学会

  1334. 慢性偽性腸閉塞症と鑑別を要した急性膵炎に続発した慢性巨大結腸症の1例

    佐藤 英昭, 石田 晶玄, 長尾 宗紀, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(4)　820-824　2018/04

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1335. 【高齢者における外科治療の意義と限界】 胆管癌手術の光と影 高難度手術の手術死亡はJustifyされるか?

    海野 倫明

    Geriatric Medicine　56　(4)　335-338　2018/04

    Publisher: (株)ライフ・サイエンス

    ISSN： 0387-1088

  1336. 術前診断が潰瘍性大腸炎であったcolitic cancerを合併したCrohn病の1例

    相澤 卓, 渡辺 和宏, 長尾 宗紀, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(4)　814-819　2018/04

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1337. The functional outcome and factors influencing the quality of life after ileal pouch anal anastomosis in patients with ulcerative colitis. Peer-reviewed

    Kazuhiro Watanabe, Munenori Nagao, Hideyuki Suzuki, Hideaki Karasawa, Shinobu Ohnuma, Hiroaki Musha, Yuji Funayama, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgery today　48　(4)　455-461　2018/04

    DOI： 10.1007/s00595-017-1613-8 　

    ISSN： 0941-1291

    More details Close

    PURPOSE: The aim of this study was to assess the bowel function and quality of life (QOL) in patients with ulcerative colitis (UC) after total proctocolectomy with ileal pouch anal anastomosis (IPAA). METHODS: Two questionnaires ["Questionnaire sheet on the bowel function" and "Inflammatory bowel disease questionnaire (Japanese IBDQ)"] were sent to 121 patients with UC who underwent IPAA at Tohoku University Hospital. Seventy-nine patients (65%) participated in the study. RESULTS: The median number of daily bowel movements was 6.5, which significantly decreased with postoperative time (≤ 1, 1-5, 5-15 years) and increased with age (< 45, ≥ 45 years at colectomy). The ratio of patients who usually had bowel movements at night also significantly decreased with postoperative time and increased with age. The median total IBDQ score was 180. A multivariate analysis showed that "trip activity", "care about where the restroom is", and "bowel movements in the day" were significant independent risk factors for the daily life satisfaction score. CONCLUSIONS: The bowel function and QOL were acceptable in patients with UC after IPAA; however, patients with a short postoperative time or older age had a lower functional outcome than others.

  1338. The Effects of Short-term Subnormothermic Perfusion After Cold Preservation on Liver Grafts From Donors After Circulatory Death: An Ex Vivo Rat Model. International-journal Peer-reviewed

    Yuta Kakizaki, Shigehito Miyagi, Kenji Shimizu, Koji Miyazawa, Wataru Nakanishi, Kazuaki Tokodai, Yasuyuki Hara, Chikashi Nakanishi, Michiaki Unno, Takashi Kamei, Masafumi Goto, Susumu Satomi

    Transplantation　102　(4)　e147-e154-e154　2018/04

    Publisher: Lippincott Williams and Wilkins

    DOI： 10.1097/TP.0000000000002080 　

    ISSN： 0041-1337

  1339. Progesterone arrested cell cycle progression through progesterone receptor isoform A in pancreatic neuroendocrine neoplasm. International-journal Peer-reviewed

    Samaneh Yazdani, Atsuko Kasajima, Yoshiaki Onodera, Keely May McNamara, Kazue Ise, Yasuhiro Nakamura, Tomoyoshi Tachibana, Fuyuhiko Motoi, Michiaki Unno, Hironobu Sasano

    The Journal of steroid biochemistry and molecular biology　178　243-253　2018/04

    Publisher: Elsevier Ltd

    DOI： 10.1016/j.jsbmb.2018.01.003 　

    ISSN： 1879-1220 0960-0760

  1340. 基礎研究から紐解く膵・胆道の恒常性とその破綻 膵切後脂肪肝の基礎的・臨床的検討

    石田 晶玄, 坂田 直昭, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A188-A188　2018/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1341. 慢性膵炎診療の現状と課題 当科における慢性膵炎手術の検討

    佐藤 英昭, 石田 晶玄, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A128-A128　2018/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1342. CA19-9正常膵癌の検討

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 下瀬川 徹, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A288-A288　2018/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1343. 手術手技 拡大手術で必要な会陰再建法 Peer-reviewed

    唐澤 秀明, 高木 尚之, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    手術　72　(3)　307-313　2018/03

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1344. Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study. International-journal Peer-reviewed

    Sumiyuki Nishida, Takeshi Ishikawa, Shinichi Egawa, Shigeo Koido, Hiroaki Yanagimoto, Jun Ishii, Yoshihide Kanno, Satoshi Kokura, Hiroaki Yasuda, Mari Saito Oba, Maho Sato, Soyoko Morimoto, Fumihiro Fujiki, Hidetoshi Eguchi, Hiroaki Nagano, Atsushi Kumanogoh, Michiaki Unno, Masanori Kon, Hideaki Shimada, Kei Ito, Sadamu Homma, Yoshihiro Oka, Satoshi Morita, Haruo Sugiyama

    Cancer immunology research　6　(3)　320-331　2018/03

    DOI： 10.1158/2326-6066.CIR-17-0386 　

    ISSN： 2326-6066

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    We investigated the efficacy of a Wilms' tumor gene 1 (WT1) vaccine combined with gemcitabine (GEMWT1) and compared it with gemcitabine (GEM) monotherapy for advanced pancreatic ductal adenocarcinoma (PDAC) in a randomized phase II study. We randomly assigned HLA-A*02:01- or HLA-A*24:02-positive patients with advanced PDAC to receive GEMWT1 or GEM. We assessed WT1-specific immune responses via delayed-type hypersensitivity (DTH) to the WT1 peptide and a tetramer assay to detect WT1-specific cytotoxic T lymphocytes (WT1-CTL). Of 91 patients enrolled, 85 were evaluable (GEMWT1: n = 42; GEM: n = 43). GEMWT1 prolonged progression-free survival [PFS; hazard ratio (HR), 0.66; P = 0.084] and improved overall survival rate at 1 year (1-year OS%; GEMWT1: 35.7%; GEM: 20.9%). However, the difference in OS was not significant (HR: 0.82; P = 0.363). These effects were particularly evident in metastatic PDAC (PFS: HR 0.51, P = 0.0017; 1-year OS%: GEMWT1 27.3%; GEM 11.8%). The combination was well tolerated, with no unexpected serious adverse events. In patients with metastatic PDAC, PFS in the DTH-positive GEMWT1 group was significantly prolonged, with a better HR of 0.27 compared with the GEM group, whereas PFS in the DTH-negative GEMWT1 group was similar to that in the GEM group (HR 0.86; P = 0.001). DTH positivity was associated with an increase in WT1-CTLs induced by the WT1 vaccine. GEM plus the WT1 vaccine prolonged PFS and may improve 1-year OS% in advanced PDAC. These clinical effects were associated with the induction of WT1-specific immune responses. Cancer Immunol Res; 6(3); 320-31. ©2018 AACR.

  1345. [Endoscopy-Assisted Partial Duodenal Resection for Duodenal Adenoma in a Patient with Familial Adenomatous Polyposis]. Peer-reviewed

    Tomoaki Hirashima, Shinobu Ohnuma, Hideaki Karasawa, Kazuhiro Watanabe, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(3)　518-520　2018/03

    ISSN： 0385-0684

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    We here report a case of endoscopy-assisted partial duodenal resection for duodenal adenoma in a patient with familial adenomatous polyposis(FAP). A male underwent total proctocolectomy with ileal pouch anal anastomosis in 1997. Since 2004, duodenal adenomas occurred and the atypical grade of adenoma was gradually aggravated. Therefore, he underwent endoscopy-assisted partial duodenal resection in 2013. The pathological finding of the specimen showed well-differentiated tubular adenocarcinoma(pM, ly0, v0). No recurrence has been observed at 4 years after the operation. Endoscopy-assisted partial duodenal resection was minimum invasive surgery and considered to be useful for the patients with duodenal adenoma.

  1346. Different strategy of salvage esophagectomy between residual and recurrent esophageal cancer after definitive chemoradiotherapy. International-journal Peer-reviewed

    Yusuke Taniyama, Tadashi Sakurai, Takahiro Heishi, Hiroshi Okamoto, Chiaki Sato, Shota Maruyama, Yu Onodera, Hirotaka Ishida, Michiaki Unno, Takashi Kamei

    Journal of thoracic disease　10　(3)　1554-1562　2018/03

    Publisher: AME Publishing Company

    DOI： 10.21037/jtd.2018.03.04 　

    ISSN： 2077-6624 2072-1439

  1347. Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. International-journal Peer-reviewed

    Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Bartosz Chemielwski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Arun S Singh, Mark A Eckardt, Michiaki Unno, Fritz C Eilber, Robert M Hoffman

    Oncotarget　9　(13)　11119-11125　2018/02/16

    Publisher: Impact Journals LLC

    DOI： 10.18632/oncotarget.24264 　

    ISSN： 1949-2553

  1348. 移植前肝細胞に対するADP/ATP ratioを用いた新規評価法の確立

    松村 宗幸, 猪村 武弘, 小笠原 弘之, 福岡 健吾, 稲垣 明子, 宮城 重人, 大橋 一夫, 海野 倫明, 亀井 尚, 里見 進, 後藤 昌史

    移植　52　(6)　557-557　2018/02

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1349. Efficacy of Sleeve Gastrectomy with Duodenal-Jejunal Bypass for the Treatment of Obese Severe Diabetes Patients in Japan: a Retrospective Multicenter Study. International-journal Peer-reviewed

    Takeshi Naitoh, Kazunori Kasama, Yosuke Seki, Masayuki Ohta, Takashi Oshiro, Akira Sasaki, Yasuhiro Miyazaki, Tsuyoshi Yamaguchi, Hideki Hayashi, Hirofumi Imoto, Naoki Tanaka, Michiaki Unno

    Obesity surgery　28　(2)　497-505　2018/02

    DOI： 10.1007/s11695-017-2874-4 　

    ISSN： 0960-8923

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    BACKGROUND: The incidence of obesity with type 2 diabetes (T2DM) is increasing in Japan. The main bariatric surgery procedures in Japan are laparoscopic sleeve gastrectomy (LSG) and LSG with duodenal-jejunal bypass (LSG/DJB) because of the high incidence of gastric cancer and difficulty exploring a remnant stomach after gastric bypass. However, few studies have compared the antidiabetic effect of LSG/DJB with LSG alone. PURPOSE: The purpose of this study is to compare the antidiabetic effect of LSG/DJB with that of LSG alone in Japanese obese diabetic patients. METHODS: This was a retrospective multicenter study including 298 cases: 177 and 121 LSG and LSG/DJB cases, respectively. We investigated the antidiabetic effect of these two procedures at 12 months after surgery. Univariate and multivariate analyses were done to evaluate the predictive factors of T2DM remission. RESULTS: The diabetes remission rate at 12 months after surgery was 80.8% for LSG and 86.0% for LSG/DJB. Insulin use and HbA1c ≤ 6.7% were significant predictive factors in multivariate analysis for all patients. In patients with ABCD score ≥ 6, the diabetes remission rate was 94.8% and there was no difference between procedures. Only duration of diabetes and insulin use were significant predictive factors both in univariate and multivariate analyses. However, in cases with ABCD score ≤ 5, the remission rate was 70.3% and procedure type was the most significant predictive factor for diabetes remission (odds ratio [OR] 5.140). CONCLUSIONS: Although both LSG and LSG/DJB have good antidiabetic effects in Japanese obese patients, LSG/DJB is more effective for patients with lower ABCD scores.

  1350. 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Recurrence in Resected Pancreatic Ductal Adenocarcinoma. International-journal Peer-reviewed

    Kyohei Ariake, Fuyuhiko Motoi, Hideo Shimomura, Masamichi Mizuma, Shimpei Maeda, Chiaki Terao, Yasuko Tatewaki, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Tatsuyuki Takadate, Takeshi Naitoh, Yasuyuki Taki, Michiaki Unno

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　22　(2)　279-287　2018/02

    DOI： 10.1007/s11605-017-3627-3 　

    ISSN： 1091-255X

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    BACKGROUND: We aimed to determine whether treatment should be stratified according to 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake values (SUVmax) in pancreatic ductal adenocarcinoma. METHODS: Patients who underwent preoperative 18F-FDG PET/CT between 2006 and 2014 (n = 138) were stratified into high (≥ 4.85) and low (< 4.85) PET groups. The clinicopathological characteristics and prognostic outcomes were analyzed retrospectively. RESULTS: The primary tumor SUVmax was positively correlated with preoperative CA19-9 levels (P < 0.001). The high PET group failed to achieve postoperative CA19-9 normalization (P = 0.014). Disease-specific (P < 0.001), recurrence-free (P < 0.001), liver recurrence-free (P < 0.001), and peritoneal recurrence-free (P = 0.020) survivals were significantly shorter in the high PET group. The primary tumor SUVmax was an independent predictive risk factor for liver metastasis (hazard ratio 3.46, 95% confidence interval 1.61-7.87; P = 0.001) and peritoneal recurrence (hazard ratio 3.36, 95% confidence interval 1.18-10.89; P = 0.023). CONCLUSIONS: Surgical resection failed to achieve CA19-9 normalization in the high PET group and distant recurrence was frequent. This suggests the potential for residual cancer at distant sites, even after curative resection. Stronger preoperative systemic chemotherapy is preferred for the high PET group patients.

  1351. Successful Endoscopic Treatment of Severe Pancreaticojejunostomy Strictures by Puncturing the Anastomotic Site with an EUS-guided Guidewire. Peer-reviewed

    Tatsuhide Nabeshima, Atsushi Kanno, Atsushi Masamune, Hiroki Hayashi, Seiji Hongo, Naoki Yoshida, Eriko Nakano, Shin Miura, Shin Hamada, Kazuhiro Kikuta, Kiyoshi Kume, Morihisa Hirota, Michiaki Unno, Tooru Shimosegawa

    Internal medicine (Tokyo, Japan)　57　(3)　357-362　2018/02/01

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.9133-17 　

    ISSN： 1349-7235 0918-2918

  1352. [Conversion Surgery for Pancreatic Head Cancer with Peritoneal Dissemination Following Chemotherapy for Two Years - A Case Report]. Peer-reviewed

    Yuuri Hatsuzawa, Masamichi Mizuma, Fuyuhiko Motoi, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Hiroki Hayashi, Takeshi Naitoh, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　45　(2)　347-349　2018/02

    ISSN： 0385-0684

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    Here we report a case of pancreatic cancer(PC)with peritoneal dissemination, underwent conversion surgery following chemotherapy for 2 years. A5 5-year-old woman was referred to our hospital for treatment of PC. Abdominal CT scan revealed 3.0 cm of a pancreatic head tumor with abutment of the portal vein and the hepatic artery, classified as borderline resectable. Staging laparoscopy(SL)showed positive peritoneal cytology(CY). Gemcitabine(Gem)plus S-1 therapy(GS) was performed. Ten months after initial GS, SL revealed the disseminated nodule and positive CY. The regimen was changed to Gem plus nab-paclitaxel therapy(Gem plus nab-PTX). Since right ovarian tumor was detected by CT scan 6 months after initial Gem plus nab-PTX, laparoscopic oophorectomy was performed. Histological findings showed positive CY and ovarian metastasis of PC. Afterward, Gem plus nab-PTX has been continued for 8 months. Since SL after 2 years from initial chemotherapy showed negative CY and no metastatic lesion, pancreaticoduodenectomy with portal vein resection was performed as conversion surgery. According to General Rules for the Study of Pancreatic Cancer the 7th edition by Japan Pancreas Society, histological findings showed ypT3, ypN0, R0, and Grade 1b of histological effect. The patient is alive without recurrence 6 months after the resection.

  1353. Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Fritz C Eilber, Robert M Hoffman

    Oncotarget　9　(1)　915-923　2018/01/02

    Publisher: Impact Journals LLC

    DOI： 10.18632/oncotarget.23185 　

    ISSN： 1949-2553

  1354. Megacolon Secondary to Acute Pancreatitis Requiring Differentiation from Chronic Intestinal Pseudo-obstruction—A Case Report—

    Hideaki SATO, Masaharu ISHIDA, Munenori NAGAO, Fuyuhiko MOTOI, Takeshi NAITOH, Michiaki UNNO

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)　79　(4)　820-824　2018

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.79.820 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  1355. 肝切除術における術前血清亜鉛値の栄養学的意義

    中西 渉, 宮城 重人, 中西 史, 原 康之, 宮澤 恒持, 清水 健司, 海野 倫明, 亀井 尚

    日本静脈経腸栄養学会雑誌　33　(Suppl.)　304-304　2018/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  1356. The utility of superb microvascular imaging for monitoring low-velocity venous flow following pancreas transplantation: report of a case. Peer-reviewed

    Tokodai K, Miyagi S, Nakanishi C, Hara Y, Nakanishi W, Miyazawa K, Shimizu K, Goto M, Kamei T, Unno M

    Journal of medical ultrasonics (2001)　45　(1)　171-174　2018/01

    DOI： 10.1007/s10396-017-0795-4 　

    ISSN： 1346-4523

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    Vascular thrombosis is a major complication after pancreas transplantation. Because delays in detecting thrombosis often result in graft failure, monitoring blood flow is crucial. Periodic evaluation using color Doppler ultrasonography is mostly performed for monitoring blood flow in the grafted pancreas. However, conventional color Doppler imaging has limited capability to visualize low-velocity blood flow. Superb microvascular imaging (SMI) is a novel ultrasound Doppler technique that is especially sensitive in detecting low-velocity flow. Herein, the authors describe the utility of SMI for monitoring splenic venous blood flow not detected by conventional color Doppler ultrasonography after pancreas transplantation. Ultrasonographic evaluation was performed every 4-6 h for 2 weeks after pancreas transplantation. SMI was used for detecting venous blood flow that was not clearly visible by conventional color Doppler imaging. The greater part of venous blood flow was undetectable by conventional color Doppler imaging, especially in the horizontal regions of the splenic vein. However, SMI clearly described venous flow at all points, even immediately after transplantation and when the patient developed hypotension due to massive bleeding complications. SMI is an extremely useful tool for monitoring venous flow after pancreas transplantation and does not require contrast agents.

  1357. Frey's procedure for chronic pancreatitis improves the nutritional status of these patients. Peer-reviewed

    Sato H, Ishida M, Motoi F, Sakata N, Aoki T, Kudoh K, Ohtsuka H, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Naitoh T, Egawa S, Unno M

    Surgery today　48　(1)　80-86　2018/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00595-017-1557-z 　

    ISSN： 0941-1291

    eISSN： 1436-2813

  1358. Synthetic Analogs of Curcumin as Modulators of Multidrug Resistance-Linked ABC Transporters Peer-reviewed

    Murakami Megumi, Ohnuma Shinobu, Kudoh Katsuyoshi, Ishida Masaharu, Iwabuchi Yoshiharu, Shibata Hiroyuki, Hayashi Hiroki, Motoi Fuyuhiko, Naitoh Takeshi, Unno Michiaki

    CANCER SCIENCE　109　63-63　2018/01

    ISSN： 1349-7006

  1359. Association between chronological depressive changes and physical symptoms in postoperative pancreatic cancer patients. International-journal Peer-reviewed

    Naoko Sato, Yoshimi Hasegawa, Asami Saito, Fuyuhiko Motoi, Kyohei Ariake, Yu Katayose, Kei Nakagawa, Kei Kawaguchi, Shin Fukudo, Michiaki Unno, Fumiko Sato

    BioPsychoSocial medicine　12　13-13　2018

    DOI： 10.1186/s13030-018-0132-1 　

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    Background: Pancreatic cancer (PC) has poorer prognosis and higher surgical invasiveness than many other cancers, with associated psychiatric symptoms including depression and anxiety. Perioperative depression has not been investigated in PC patients regarding surgical stress and relevant interventions. Methods: We evaluated chronological depressive changes and subjective physical symptoms in surgically treated PC patients preoperatively and at 3 and 6 months postoperatively.Enrolled patients undergoing pancreatic tumor surgery completed questionnaires based on the Self-Rating Depression Scale (SDS) and Functional Assessment of Cancer Therapy for Patients with Hepatobiliary Cancer (FACT-Hep) preoperatively, and at 3 and 6 months postoperatively. Responses were analyzed with JMP® Pro using one-way and two-way ANOVA, Spearman's rank correlation coefficient, and multiple regression analysis. Results: Malignancy was diagnosed in 73 of 101 patients postoperatively; SDS score was significantly higher in these patients than in those with benign tumors at all timepoints: malignant/benign, 41.8/37.9 preoperatively (p = 0.004); 43.5/37.8 3 months postoperatively (p = 0.006); and 42.9/37.7 6 months postoperatively (p = 0.020). SDS scores were significantly higher in patients < 65 years old with malignancy at 3 months than at 6 months postoperatively (44.6/42.5, p = 0.046) and in patients with malignancy who underwent pancreaticoduodenectomy at 3 months postoperatively than preoperatively (43.4/41.1; p = 0.028). SDS scores moderately correlated with 8 physical symptom-related FACT-Hep items 3 months postoperatively (p < 0.05), showing low-to-moderate correlation with 16 physical symptom-related FACT-Hep items at 6 months postoperatively (p < 0.05). Multiple regression analysis of FACT-Hep symptoms significantly correlated with SDS scores revealed the following significant variables: "lack of energy" (p < 0.000) and "pain" (p = 0.018) preoperatively (R2 = 0.43); "able to perform usual activities" (p = 0.031) and "lack of energy" (p < 0.000) at 3 months postoperatively (R2 = 0.51); and "stomach swelling or cramps" (p = 0.034) and "bowel control" (p = 0.049) at 6 months postoperatively (R2 = 0.52). Conclusions: PC patients experience persistently high levels of depression preoperatively through 6 months postoperatively, with associated subjective symptoms including pain and gastrointestinal symptoms. Trial registration: UMIN Clinical Trials Registry 000009592, Registered 20 December 2012.

  1360. Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer. International-journal Peer-reviewed

    Takashi Hirosawa, Masaharu Ishida, Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M Selaru, Michiaki Unno

    PloS one　13　(11)　e0206643　2018

    DOI： 10.1371/journal.pone.0206643 　

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    BACKGROUND: BRCA-1 associated protein (BAP1) is a de-ubiquitinating enzyme that regulates gene expression. Recently, the BAP1 mutation and its involvement in cancer survival have been reported in a range of tumor types, including uveal melanoma, mesothelioma, renal cancers, and biliary tract cancers. However, the frequency of BAP1 mutation and down-regulation varies among tumor types, and little is known about the function of BAP1 silencing in cancer cells. Gallbladder carcinoma (GBC) is a type of biliary tract cancer with a poor prognosis. Few mutational studies have investigated the role of BAP1 in GBC, and no functional study in vitro-, or clinical studies about cancer survival have been done. METHODS: GBC cells were studied by following the small interfering RNA mediated silencing of BAP1 with regard to proliferation, migration, invasion, and drug sensitivity. We carried out genomic, epigenomic and immunohistochemical analyses to detect somatic BAP1 alterations in 47 GBC patients undergoing surgical resection. RESULTS: BAP1 depletion resulted in increased migration and invasion, but not proliferation, and also resulted in decreased sensitivity to bortezomib, a proteasome inhibitor. Suppressed expression of BAP1 occurred in 22 GBC cases (46.8%) and showed a strong trend toward a worse median survival time of 13.3 months (95% CI, 17.6-62.6) (p = 0.0034). Sanger sequencing revealed a loss-of-function mutation of BAP1 in 11 out of these 22 GBC cases (50%) with low BAP1 expression, whereas 2 out of 25 GBC cases (8%) were detected in cases with high BAP1 expression. Partial changes in methylation were observed in 6 out of 47 cases, but methylation did not show a strong relationship to BAP1 expression or to the prognosis. CONCLUSION: Our findings showed that genetic mutations are involved in BAP1 down-regulation, leading to promotion of the invasive character of cancer cells and poor prognosis in GBC.

  1361. Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study. International-journal Peer-reviewed

    Tomohisa Yamamoto, Sohei Satoi, Manabu Kawai, Fuyuhiko Motoi, Masayuki Sho, Ken-Ichiro Uemura, Ippei Matsumoto, Goro Honda, Ken-Ichi Okada, Takahiro Akahori, Hirochika Toyama, Masanao Kurata, Hiroaki Yanagimoto, Hiroki Yamaue, Michiaki Unno, Masanori Kon, Yoshiaki Murakami

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　18　(1)　106-113　2018/01

    DOI： 10.1016/j.pan.2017.11.005 　

    ISSN： 1424-3903

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    OBJECTIVES: We retrospectively investigated the operative outcomes of patients who underwent distal pancreatectomy (DP) for invasive pancreatic ductal adenocarcinoma (PDAC) located at the body and tail. METHODS: Data from 395 patients with PDAC who underwent DP with margin-negative resection (R0 or R1) were collected from seven high-volume centers in Japan from 2001 to 2012. Among them, 72 patients underwent DP with en-bloc celiac axis resection (DP-CAR). The remaining 323 patients underwent conventional DP with splenectomy (DP-S). To determine the efficacy of DP-CAR, clinicopathological data were compared between the DP-CAR and the DP-S groups. RESULTS: The DP-S group consisted mainly of patients with resectable disease (93%), and conversely, all patients in the DP-CAR group had borderline resectable or unresectable disease. The overall morbidity was significantly higher in the DP-CAR group than in the DP-S group (63% vs 47%, respectively; P = 0.017). The median survival time (MST) of the DP-CAR group was significantly shorter than that of the DP-S group (17.5 vs 28.6 months, respectively; P = 0.004). However, the MST of patients in the DP-CAR group (n = 61, 85%) who received adjuvant therapy was significantly longer than that of patients in the DP-S group (n = 65, 20%) who underwent R1 resection (21.9 vs 16.7 months, respectively; P = 0.024). CONCLUSION: DP-CAR followed by adjuvant chemotherapy provided an acceptable overall survival rate in patients with highly advanced PDAC, but should be performed with great caution because of high morbidity. Patients with a high risk of positive surgical margins with DP-S may be candidates for DP-CAR.

  1362. Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention. International-journal Peer-reviewed

    Kei Kawaguchi, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Arun S Singh, Mark A Eckardt, Michiaki Unno, Fritz C Eilber, Robert M Hoffman

    Cell cycle (Georgetown, Tex.)　17　(3)　356-361　2018

    Publisher: Taylor and Francis Inc.

    DOI： 10.1080/15384101.2017.1405195 　

    ISSN： 1551-4005 1538-4101

  1363. Individualized doxorubicin sensitivity testing of undifferentiated soft tissue sarcoma (USTS) in a patient-derived orthotopic xenograft (PDOX) model demonstrates large differences between patients. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Arun S Singh, Michiaki Unno, Fritz C Eilber, Robert M Hoffman

    Cell cycle (Georgetown, Tex.)　17　(5)　627-633　2018

    Publisher: Taylor and Francis Inc.

    DOI： 10.1080/15384101.2017.1421876 　

    ISSN： 1551-4005 1538-4101

  1364. Allele-specific DNA methylation of disease susceptibility genes in Japanese patients with inflammatory bowel disease. International-journal Peer-reviewed

    Hirofumi Chiba, Yoichi Kakuta, Yoshitaka Kinouchi, Yosuke Kawai, Kazuhiro Watanabe, Munenori Nagao, Takeo Naito, Motoyuki Onodera, Rintaro Moroi, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Hisashi Shiga, Katsuya Endo, Kenichi Negoro, Masao Nagasaki, Michiaki Unno, Tooru Shimosegawa

    PloS one　13　(3)　e0194036　2018

    DOI： 10.1371/journal.pone.0194036 　

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    BACKGROUND: Inflammatory bowel disease (IBD) has an unknown etiology; however, accumulating evidence suggests that IBD is a multifactorial disease influenced by a combination of genetic and environmental factors. The influence of genetic variants on DNA methylation in cis and cis effects on expression have been demonstrated. We hypothesized that IBD susceptibility single-nucleotide polymorphisms (SNPs) regulate susceptibility gene expressions in cis by regulating DNA methylation around SNPs. For this, we determined cis-regulated allele-specific DNA methylation (ASM) around IBD susceptibility genes in CD4+ effector/memory T cells (Tem) in lamina propria mononuclear cells (LPMCs) in patients with IBD and examined the association between the ASM SNP genotype and neighboring susceptibility gene expressions. METHODS: CD4+ effector/memory T cells (Tem) were isolated from LPMCs in 15 Japanese IBD patients (ten Crohn's disease [CD] and five ulcerative colitis [UC] patients). ASM analysis was performed by methylation-sensitive SNP array analysis. We defined ASM as a changing average relative allele score ([Formula: see text]) >0.1 after digestion by methylation-sensitive restriction enzymes. Among SNPs showing [Formula: see text] >0.1, we extracted the probes located on tag-SNPs of 200 IBD susceptibility loci and around IBD susceptibility genes as candidate ASM SNPs. To validate ASM, bisulfite-pyrosequencing was performed. Transcriptome analysis was examined in 11 IBD patients (seven CD and four UC patients). The relation between rs36221701 genotype and neighboring gene expressions were analyzed. RESULTS: We extracted six candidate ASM SNPs around IBD susceptibility genes. The top of [Formula: see text] (0.23) was rs1130368 located on HLA-DQB1. ASM around rs36221701 ([Formula: see text] = 0.14) located near SMAD3 was validated using bisulfite pyrosequencing. The SMAD3 expression was significantly associated with the rs36221701 genotype (p = 0.016). CONCLUSIONS: We confirmed the existence of cis-regulated ASM around IBD susceptibility genes and the association between ASM SNP (rs36221701) genotype and SMAD3 expression, a susceptibility gene for IBD. These results give us supporting evidence that DNA methylation mediates genetic effects on disease susceptibility.

  1365. Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Miyake, Qinghong Han, Shukuan Li, Yuying Tan, Kentaro Igarashi, Thinzar M Lwin, Takashi Higuchi, Tasuku Kiyuna, Masuyo Miyake, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Cell cycle (Georgetown, Tex.)　17　(7)　868-873　2018

    DOI： 10.1080/15384101.2018.1445907 　

    ISSN： 1538-4101

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    Pancreatic cancer is a recalcitrant disease. Gemcitabine (GEM) is the most widely-used first-line therapy for pancreatic cancer, but most patients eventually fail. Transformative therapy is necessary to significantly improve the outcome of pancreatic cancer patients. Tumors have an elevated requirement for methionine and are susceptible to methionine restriction. The present study used a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer to determine the efficacy of recombinant methioninase (rMETase) to effect methionine restriction and thereby overcome GEM-resistance. A pancreatic cancer obtained from a patient was grown orthotopically in the pancreatic tail of nude mice to establish the PDOX model. Five weeks after implantation, 40 pancreatic cancer PDOX mouse models were randomized into four groups of 10 mice each: untreated control (n = 10); GEM (100 mg/kg, i.p., once a week for 5 weeks, n = 10); rMETase (100 units, i.p., 14 consecutive days, n = 10); GEM+rMETase (GEM: 100 mg/kg, i.p., once a week for 5 weeks, rMETase: 100 units, i.p., 14 consecutive days, n = 10). Although GEM partially inhibited PDOX tumor growth, combination therapy (GEM+rMETase) was significantly more effective than mono therapy (GEM: p = 0.0025, rMETase: p = 0.0010). The present study is the first demonstrating the efficacy of rMETase combination therapy in a pancreatic cancer PDOX model to overcome first-line therapy resistance in this recalcitrant disease.

  1366. Surgical outcomes in gastroenterological surgery in Japan: Report of National Clinical database 2011-2016. Peer-reviewed

    Yoshihiro Kakeji, Arata Takahashi, Harushi Udagawa, Michiaki Unno, Itaru Endo, Chikara Kunisaki, Akinobu Taketomi, Akira Tangoku, Tadahiko Masaki, Shigeru Marubashi, Kazuhiro Yoshida, Mitsukazu Gotoh, Hiroyuki Konno, Hiroaki Miyata, Yasuyuki Seto

    Annals of gastroenterological surgery　2　(1)　37-54　2018/01

    DOI： 10.1002/ags3.12052 　

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    The National Clinical Database (NCD) of Japan started its registration in 2011 and over 9 000 000 cases from more than 5000 facilities were registered over a 6-year period. This is the report of NCD based upon gastrointestinal surgery information in excess of 3 200 000 cases from 2011 to 2016 adding data of complications. About 70% of all gastrointestinal surgeries were carried out at certified institutions, and the percentage of surgeries done at certified institutions was particularly high for the esophagus (92.4% in 2016), liver (88.4%), pancreas (89.8%), and spleen (86.8%). The percentage of anesthesiologist participation was more than 90% for almost all organs, except 85.7% for the rectum and anus. Approximately, more than two-thirds of the surgeries were carried out with the participation of a board-certified surgeon. Although patients have been getting older, mortalities have not been increasing. There were differences in the incidence of complications according to organ site and procedure. Remarkably, mortality rates of low anterior resection were very low, and those of hepatectomy and acute diffuse peritonitis surgery have been gradually decreasing. Although the complication rates were gradually increasing for esophagectomy or pancreaticoduodenectomy, the mortality rates for these procedures were decreasing. Nationwide, this database is expected to ensure the quality of the board-certification system and surgical outcomes in gastroenterological surgery.

  1367. Tumor targeting Salmonella typhimurium A1-R in combination with gemcitabine (GEM) regresses partially GEM-resistant pancreatic cancer patient-derived orthotopic xenograft (PDOX) nude mouse models. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Miyake, Ming Zhao, Tasuku Kiyuna, Kentaro Igarashi, Masuyo Miyake, Takashi Higuchi, Hiromichi Oshiro, Michael Bouvet, Michiaki Unno, Robert M Hoffman

    Cell cycle (Georgetown, Tex.)　17　(16)　2019-2026　2018

    DOI： 10.1080/15384101.2018.1480223 　

    ISSN： 1538-4101

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    Gemcitabine (GEM) is first-line therapy for pancreatic cancer but has limited efficacy in most cases. Nanoparticle-albumin bound (nab)-paclitaxel is becoming first-line therapy for pancreatic cancer, but also has limited efficacy for pancreatic cancer. Our goal was to improve the treatment outcome in patient-like models of pancreatic cancer. We previously established patient-derived orthotopic xenografts (PDOX) pancreatic cancers from two patients. The pancreatic tumor was implanted orthotopically in the pancreatic tail of nude mice to establish the PDOX models. Five weeks after implantation, 50 PDOX mouse models were randomized into five groups of 10 mice for each pancreatic cancer PDOX: untreated control; GEM (100 mg/kg, i.p., once a week for 2 weeks); GEM + nab-PTX (GEM: 100 mg/kg, i.p., once a week for 2 weeks, nab-PTX: 10 mg/kg, i.v., twice a week for 2 weeks); S. typhimurium A1-R (5 × 107 CFU/100 μl, i.v., once a week for 2 weeks); GEM + S. typhimurium A1-R (GEM: 100 mg/kg, i.p., once a week for 2 weeks, S. typhimurium A1-R; 5 × 107 CFU/100 μl, i.v., once a week for 2 weeks). GEM + nab-PTX was significantly more effective than GEM alone in one PDOX model (p = 0.0004), but there was no significant difference in the other PDOX model. The combination of GEM + S. typhimurium A1-R regressed both PDOX models. These results show S. typhimurium A1-R can overcome the ineffectiveness or partial effectiveness of GEM in patient-like models of pancreatic cancer and demonstrate clinical potential for this combination.

  1368. A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis. International-journal Peer-reviewed

    Mitsuhiro Shimura, Masamichi Mizuma, Hiroki Hayashi, Akiko Mori, Tomoyoshi Tachibana, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Kyohei Ariake, Shimpei Maeda, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Takeshi Naitoh, Takashi Kamei, Fuyuhiko Motoi, Michiaki Unno

    Surgical case reports　3　(1)　132-132　2017/12/29

    DOI： 10.1186/s40792-017-0409-9 　

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    BACKGROUND: Pancreatic cancer with distant metastases is classified as "unresectable," for which the standard treatment is systemic chemotherapy. The effectiveness of radical resection for pancreatic cancer with distant metastases is unknown. Here, we report a case of long term survival treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis. CASE PRESENTATION: A 73-year-old man was referred to our hospital to examine and treat for cancer of the pancreatic body. Computed tomography (CT) scan revealed a 26-mm hypovascular tumor in contact with the common hepatic artery (CHA) (> 180°), the celiac artery (< 180°), and portal vein at the pancreatic body. Resectability was determined as "borderline resectable." Two courses of gemcitabine plus S-1 combination therapy (GS) were administered as neoadjuvant chemotherapy (NAC). CT scan showed tumor shrinkage (21 mm), determined as stable disease (SD) according to Response Evaluation Criteria in Solid Tumors (RECIST). Although the abdomen was opened for radical resection, a small nodule on the liver was detected and removed. Since the nodule was diagnosed as adenocarcinoma by intraoperative frozen section, resection of the primary tumor was not performed. After three subsequent courses of GS therapy, no distant metastases were detected under radiological findings. Distal pancreatectomy with celiac artery resection (DP-CAR) was performed as radical surgery 6 months after the initial diagnosis. Histological diagnosis was well-differentiated tubular adenocarcinoma, showing ypT1 ypN1 M1 stage IV, negative surgical margin (R0), and grade III in the Evans classification. S-1 was administered every other day from 6 months after resection up to the present. The patient has been alive with no recurrence for 5 years after the initial diagnosis and 4.5 years after the resection. CONCLUSION: There is a case that received survival benefits from conversion surgery following chemotherapy after diagnostic metastasectomy in pancreatic cancer with synchronous liver metastasis.

  1369. Natural History and Chronological Growth Rate of Renal Artery Aneurysms. Peer-reviewed

    Michihisa Umetsu, Hitoshi Goto, Masato Ohara, Munetaka Hashimoto, Takuya Shimizu, Daijirou Akamatsu, Ken Tsuchida, Yuta Tajima, Shunya Suzuki, Keisuke Yamamoto, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

    Annals of vascular diseases　10　(4)　411-416　2017/12/25

    DOI： 10.3400/avd.oa.17-00075 　

    ISSN： 1881-641X

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    Objective: Renal artery aneurysm (RAA) is an uncommon disease, the natural course of which is still not well known. The objective of this study is to define factors that affect the growth rate of RAAs. Materials and Methods: We retrospectively reviewed 32 aneurysms in 26 patients at our institute between January 2010 and March 2016. Basal demographics, comorbidities, reason for diagnosis, and details of the aneurysms and interventions were recorded. The chronological changes in the diameter of the RAA using multiplanar reconstructions of computed tomography images were measured and analyzed. Results: The baseline mean diameter was 20.1±8.4 mm (range: 9.9-41). The mean follow-up period was 3.13±2.1 y (range: 0.5-7.1). The median growth rate was 0.35 mm/y (interquartile range: 0.05, 0.62). The growth rate was slower when the initial diameter was <20 mm than when it was >20 mm (p=0.036). Also, whole-completed calcification was a significant factor for slower growth (p=0.016). We performed ex-vivo surgery in two cases and coil packing with stenting in one. No ruptures occurred during the study period. Conclusion: Our results suggest that cases with an RAA diameter <20 mm do not require intervention. The interval period can be longer in whole-completed calcification types.

  1370. 高齢者食道癌に対する腹臥位胸腔鏡下食道切除術の検討 側臥位との比較

    岡本 宏史, 谷山 裕亮, 櫻井 直, 佐藤 千晃, 丸山 祥太, 石田 裕嵩, 小野寺 優, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　22　(7)　EP148-07　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1371. High-riding innominate arteryを伴う食道癌に対しNerve Integrity Monitorを用い反回神経を温存しえた1例

    堀江 悠太, 石田 裕嵩, 小野寺 優, 丸山 祥太, 岡本 宏史, 佐藤 千晃, 櫻井 直, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本内視鏡外科学会雑誌　22　(7)　EP193-07　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1372. A Case of Successful Simultaneous Pancreas-Kidney Transplantation Using the Injured Pancreas Graft Invited Peer-reviewed

    S. Miyagi, K. Shimizu, K. Miyazawa, W. Nakanishi, Y. Hara, K. Tokodai, C. Nakanishi, S. Satomi, M. Goto, M. Unno, T. Kamei

    TRANSPLANTATION PROCEEDINGS　49　(10)　2315-2317　2017/12

    DOI： 10.1016/j.transproceed.2017.10.017 　

    ISSN： 0041-1345

    eISSN： 1873-2623

  1373. Gallbladder cancer

    中川 圭, 海野 倫明

    臨床外科 = Journal of clinical surgery　72　(13)　1432-1439　2017/12

    Publisher: 医学書院

    DOI： 10.11477/mf.1407211875 　

    ISSN： 0386-9857

  1374. Predictive risk factors for peritoneal recurrence after pancreatic cancer resection and strategies for its prevention Peer-reviewed

    Kyohei Ariake, Fuyuhiko Motoi, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Shimpei Maeda, Tatsuyuki Takadate, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno

    SURGERY TODAY　47　(12)　1434-1442　2017/12

    DOI： 10.1007/s00595-017-1531-9 　

    ISSN： 0941-1291

    eISSN： 1436-2813

  1375. Locally advanced pancreatic cancer successfully treated by distal pancreatectomy with celiac axis resection (DP-CAR) after S-1 with radiation therapy followed by gemcitabine/nab-paclitaxel therapy: a case report. International-journal Peer-reviewed

    Ariake K, Motoi F, Mizuma M, Murakami K, Takadate T, Ohtsuka H, Fukase K, Masuda K, Hayashi H, Nakagawa K, Sakata N, Morikawa T, Maeda S, Naitoh T, Egawa S, Unno M

    Surgical case reports　3　(1)　15-15　2017/12

    DOI： 10.1186/s40792-017-0290-6 　

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    BACKGROUND: The prognosis for pancreatic cancer remains dismal because many patients are diagnosed with unresectable cancer at the initial diagnosis. Recently, conversion surgery was reported as an effective treatment for initially unresectable pancreatic cancer with a favorable response to non-surgical treatment lasting over 240 days. Here, we describe a case of locally advanced pancreatic cancer (LAPC) successfully resected after treatment with S-1 and radiation followed by gemcitabine/nab-paclitaxel therapy. CASE PRESENTATION: A 73-year-old man with LAPC was referred to our hospital. Computed tomography findings revealed a 2.5-cm mass in the pancreatic body that had invaded the celiac artery, common hepatic artery, and splenic artery. Superior mesenteric artery (SMA) encasement was not observed, but tumor abutment over 180° with the main tumor was detected. Staging laparoscopy showed no findings of distant metastasis, and washing cytology revealed no malignancy. He was diagnosed with unresectable pancreatic cancer. Treatment with S-1 with radiation therapy followed by gemcitabine with nab-paclitaxel was performed. Six months after the initial treatment, the tumor size had decreased to 1.2 cm, and encasement of the main artery was diminished. Though abutment to the main artery, including the SMA, was still detected, distal pancreatectomy with celiac artery resection was performed. The histopathological findings around the celiac artery revealed fibrous changes with an Evans classification of grade IIb. There was no residual cancer at the periphery; thus, R0 resection was achieved. The patient has been healthy and without recurrence for more than 12 months since the initial treatment. CONCLUSIONS: Gemcitabine/nab-paclitaxel therapy revealed high response rate for metastasic pancreatic cancer (PC), but the effect for LAPC proposing conversion surgery was not well discussed. In this case, we achieve R0 resection combined with chemoradiation therapy and gemcitabine/nab-paclitaxel therapy. This regimen was also effective for LAPC and may be used to increase the population of conversion surgery by its high response rate.

  1376. A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. International-journal Peer-reviewed

    Mori A, Fukase K, Masuda K, Sakata N, Mizuma M, Ohtsuka H, Morikawa T, Nakagawa K, Hayashi H, Motoi F, Naitoh T, Murakami K, Unno M

    Surgical case reports　3　(1)　19-19　2017/12

    DOI： 10.1186/s40792-017-0295-1 　

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    BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant mesenchymal tumor that usually occurs in children and is rarely diagnosed in adults. CASE PRESENTATION: Here, we describe the case of a 65-year-old woman who presented with a huge cystic lesion in the liver. Laboratory studies performed on admission showed modest inflammation, poor nutrition, and elevated levels of total bilirubin, alkaline phosphatase, and γ-glutamyl transferase. Computed tomography showed a well-defined, heterogeneous tumor with multiple cysts involving the right lobe and the medial segment of the liver, with a maximum diameter of 16 cm. Positron emission tomography/computed tomographic scans showed the uptake of 2-(fluorine-18)-fluoro-2-deoxy-D-glucose in a part of the cyst. The patient was diagnosed with mucinous cystadenocarcinoma or sarcoma of the liver and underwent right trisectionectomy. Histopathological studies revealed that the tumor was composed of pleomorphic and polynuclear dyskaryotic cells with eosinophilic globules in the cytoplasm. Mesenchymal hamartoma-like tissue was observed in the peripheral part of the tumor. Immunohistochemical analyses showed the tumor stained with vimentin, α-smooth muscle actin, desmin, α1-antitrypsin, and α1-antichymotripsin. Therefore, a histological diagnosis of UESL was made. Eighteen months following treatment, two recurrent tumors in the remnant liver were detected and resection of the recurrent tumors was performed. CONCLUSIONS: A UESL should be considered in the differential diagnosis of large cystic hepatic lesions. Although the prognosis of UESL is extremely unfavorable, aggressive surgical resection should be the most important factor for ensuring long-term survival.

  1377. microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer. International-journal Peer-reviewed

    Hidekazu Takahashi, Masanobu Takahashi, Shinobu Ohnuma, Michiaki Unno, Yuki Yoshino, Kota Ouchi, Shin Takahashi, Yasuhide Yamada, Hideki Shimodaira, Chikashi Ishioka

    BMC cancer　17　(1)　723-723　2017/11/07

    DOI： 10.1186/s12885-017-3739-x 　

    ISSN： 1471-2407

    eISSN： 1471-2407

  1378. 移植前肝細胞におけるviability評価法としてのADP/ATP assayの有用性に関する検証

    松村 宗幸, 猪村 武弘, 小笠原 弘之, 福岡 健吾, 稲垣 明子, 宮城 重人, 大橋 一夫, 海野 倫明, 亀井 尚, 里見 進, 後藤 昌史

    Organ Biology　24　(3)　91-91　2017/11

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1379. Retrospective Study of the Correlation Between Pathological Tumor Size and Survival After Curative Resection of T3 Pancreatic Adenocarcinoma: Proposal for Reclassification of the Tumor Extending Beyond the Pancreas Based on Tumor Size Peer-reviewed

    Masanao Kurata, Goro Honda, Yoshiaki Murakami, Kenichiro Uemura, Sohei Satoi, Fuyuhiko Motoi, Masayuki Sho, Ippei Matsumoto, Manabu Kawai, Hiroaki Yanagimoto, Takumi Fukumoto, Minako Nagai, Masahiko Gosho, Michiaki Unno, Hiroki Yamaue

    WORLD JOURNAL OF SURGERY　41　(11)　2867-2875　2017/11

    DOI： 10.1007/s00268-017-4077-5 　

    ISSN： 0364-2313

    eISSN： 1432-2323

  1380. Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2. International-journal Peer-reviewed

    Megumi Murakami, Shinobu Ohnuma, Michihiro Fukuda, Eduardo E Chufan, Katsuyoshi Kudoh, Keigo Kanehara, Norihiko Sugisawa, Masaharu Ishida, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V Ambudkar, Michiaki Unno

    Drug metabolism and disposition: the biological fate of chemicals　45　(11)　1166-1177　2017/11

    DOI： 10.1124/dmd.117.076000 　

    ISSN： 0090-9556

    eISSN： 1521-009X

  1381. The extra-anatomical jump graft reconstruction of the right hepatic artery after resection of a biliary tract malignancy with a common hepatic artery aneurysm: a case report. International-journal Peer-reviewed

    Yuta Kakizaki, Shigehito Miyagi, Yasuyuki Hara, Atsushi Fujio, Koji Miyazawa, Kai Maida, Toshiaki Kashiwadate, Kazuaki Tokodai, Chikashi Nakanishi, Takashi Kamei, Michiaki Unno

    Clinical case reports　5　(11)　1841-1846　2017/11

    DOI： 10.1002/ccr3.1200 　

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    Performing resection of a biliary tract malignancy with a hepatic artery aneurysm is very challenging. Resection of the extrahepatic bile duct and extra-anatomical reconstruction can be successfully performed using free radial artery autografts from the aorta to the right hepatic artery. Hepatic artery thrombosis can be prevented with intimal preservation.

  1382. [A Case of Leiomyosarcoma of the Small Intestine with Intestinal Hemorrhage Due to Intraluminal Penetration]. Peer-reviewed

    Takahiro Tsuchiya, Naoki Tanaka, Munenori Nagao, Kazuhiro Watanabe, Hirofumi Imoto, Shinobu Ohnuma, Hiroaki Musha, Mika Watanabe, Keigo Murakami, Fumiyoshi Fujishima, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　44　(12)　1068-1070　2017/11

    ISSN： 0385-0684

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    A 40-year-old man was referred to our hospital because of severe anemia and small intestinal tumor revealed by computed tomography. The enteroscopy exam showed the intraluminal penetration of the tumor, which was considered as a cause of anemia. Although emergency operation was performed laparoscopically, intraoperative findings indicated tumor invasion into peritoneum, and we converted from laparoscopic surgery to open surgery that included concomitant peritoneum resection. Histopathological findings showed spindle-shaped tumor cells with severe atypia. Immunohistochemical study showed tumor cells to be positive for aSMA, but negative for c-kit and CD34, then we diagnosed the tumor as leiomyosarcoma of the ileum. Since leiomyosarcoma of the small intestine is a rare entity, we have reported with literature consideration.

  1383. [Multidisciplinary Therapy with Gemcitabine and Nab-Paclitaxel for Unresectable Pancreatic Cancer]. Peer-reviewed

    Fuyuhiko Motoi, Tatsuyuki Takadate, Shimpei Maeda, Kyohei Ariake, Kunihiro Masuda, Masaharu Ishida, Koji Fukase, Masamichi Mizuma, Hideo Ohtsuka, Naoaki Sakata, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　44　(12)　1241-1244　2017/11

    ISSN： 0385-0684

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    Gemcitabine with nab-paclitaxel(GN)shows promisinganti -tumor effect and has been established standard regimen for metastatic pancreatic cancer(PC). Conversion surgery(CS), recently reported about initially unresectable PC with favorable response to non-surgical treatment, might provide long-term survival. The aim of this study is to evaluate the efficacy of multi-modal treatment includingCS after GN therapy for initially unresectable PC. From 2015 to 2016, 29 initially unresectable PC treated with chemotherapy includingGN were eligible for the retrospective analysis. Unresectability was defined over 180- degree abutment to major arteries(UR-LA)or suspicious small metastases(UR-M). CS was planed after clinical favorable response over 6 months of treatment duration. Median age of the patients was 62.5 years old, including 18 males and 11 females. Tumor in the pancreas head(n=20)was dominant. Eighteen patients were UR-LA and remaining1 1 were UR-M. CS was performed in 9 cases(31%)with no significant difference between UR-LA and UR-M. CS showed significant better survival with 67%of 2-year survival rate, compared to without CS(p=0.039). GN regimen effectively induced CS for initially unresectable PC. Multidisciplinary therapy includinginduction GN and CS might have survival impact on unresectable PC.

  1384. [A Case of Curatively Resected Ascending Colon Cancer with Ovarian Metastasis and Peritoneal Dissemination after Chemotherapy]. Peer-reviewed

    Yasushi Mochizuki, Hideaki Karasawa, Hideki Shimodaira, Shinobu Ohnuma, Kazuhiro Watanabe, Shimpei Maeda, Munenori Nagao, Takeshi Aoki, Katsuyoshi Kudo, Naoki Tanaka, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　44　(12)　1711-1713　2017/11

    ISSN： 0385-0684

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    A52 -year-old woman was diagnosed with ascending colon cancer with ovarian metastasis and peritoneal dissemination. Since the patient did not have symptoms with intestinal obstruction, mFOLFOX6 plus bevacizumab(Bmab)was performed for 12 cycles. After chemotherapy, the tumors of ascending colon and ovary were significantly shrunken and novel distant metastasis was not observed by CT scans. Therefore, the tumors were considered to be resectable and curative resection was performed. In the surgical findings, the peritoneal disseminations were localized, and right colectomy, bilateral oophorectomy and extirpation of the peritoneal disseminations were performed. R0 resection was pathologically achieved and adjuvant chemotherapy with UFT/UZEL was administrated for 6 months. The patient is alive without recurrence for 1 year. Since right sided colon cancer is less likely to have obstruction, upfront chemotherapy can be a strategy for locally advanced right sided colon cancer with distant metastasis.

  1385. [A Case of Successful Adjuvant Surgery for the Pancreas Head Cancer with Peritoneal Metastasis]. Peer-reviewed

    Yukie Kyakumoto, Tatsuyuki Takadate, Masamichi Mizuma, Tatsuo Hata, Masahiro Iseki, Hideo Ohtsuka, Naoaki Sakata, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Takeshi Naitoh, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　44　(12)　1880-1882　2017/11

    ISSN： 0385-0684

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    We report a case of the pancreas head cancer with peritoneal metastasis, which was resected curatively after chemotherapy. A6 6-year-old male was referred to our hospital for the treatment of biliary stenosis. The serum CA19-9 level was elevated and abdominal CT scan showed stenosis of distal bile duct. By laparotomy, we noticed mass in the head of the pancreas with 8mm of the seeding nodule in a diameter at jejunal mesentery which was diagnosed as adenocarcinoma by intraoperative frozen sections. Therefore, the patient was diagnosed as pancreas head cancer with peritoneal metastasis. After hepaticojejunostomy, we started chemotherapy planning adjuvant surgery if the clinical response was observed. Systemic chemotherapy with gemcitabine and nab-paclitaxel was administrated on days 1, 8 and 15 every 4 weeks. After 5 courses, therapeutic effect was stable disease(SD)in response evaluation criteria in solid tumor(RECIST). All of tumor markers were normalized. Subtotal stomach-preserving pancreatoduodenectomy(SSPPD)was performed 6 months after the initial surgery. Histopathologically, most cancer cells showed degeneration and eliminated in the head of the pancreas. R0 resection was achieved with diagnosis of ypT3, ypN1, pM1(PER), Stage IV . Histological therapeutic effect was Grade III according to the Evans classification. The patient is alive, with no sign of recurrence 8 months after surgery. Adjuvant surgery was suggested to be one of the therapeutic options for pancreatic cancer with peritoneal metastasis.

  1386. [Multidisciplinary Treatment for Squamous Cell Carcinoma of the Anal Canal]. Peer-reviewed

    Hideaki Karasawa, Shinobu Ohnuma, Kazuhiro Watanabe, Takahiro Tsuchiya, Hirofumi Imoto, Takeshi Aoki, Katsuyoshi Kudoh, Naoki Tanaka, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Fuyuhiko Motoi, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Gan to kagaku ryoho. Cancer & chemotherapy　44　(12)　2009-2010　2017/11

    ISSN： 0385-0684

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    Chemoradiotherapy(CRT)has been recognized as a standard treatment for locoregional squamous cell carcinoma of the anal canal in Western countries. However, surgery had historically been considered as a standard treatment and there are only a few reports on CRT for anal canal cancer in Japan. In this study, we analyzed medical records of 5 anal canal cancer patients treated with CRT in our hospital between 2005 and 2015. Patients' characteristics were as follows: median age, 70 years (range 42-80 years); male/female, 1/4; and clinical Stage I / III a/ III b, 3/1/1. The regimens of chemotherapy were MMC plus 5-FU in 4 patients and CDDP in 1 patient. The median follow-up period was 30 months(range, 6 to 100 months). After CRT, 4 patients achieved complete response. The other patient with partial response underwent salvage surgery. All patients were alive without recurrence. In conclusion, our retrospective study showed that CRT is considered to be a standard treat- ment for anal canal cancer.

  1387. The comparative anatomy of the folds, fossas, and adhesions around the duodenojejunal flexure in mammals. Peer-reviewed

    Masaharu Ishida, Naoaki Sakata, Ichiro Ise, Tomoyuki Ono, Mitsuhiro Shimura, Kentaro Ishii, Megumi Murakami, Tatsuyuki Takadate, Takeshi Aoki, Katsuyoshi Kudo, Shinobu Ohnuma, Koji Fukase, Hideo Ohtsuka, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    Folia Morphol (Warsz)　2017/10/24

    DOI： 10.5603/FM.a2017.0089 　

  1388. Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. International-journal Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Tasuku Kiyuna, Kentaro Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Fritz C Eilber, Robert M Hoffman

    Oncotarget　8　(49)　85516-85525　2017/10/17

    DOI： 10.18632/oncotarget.20231 　

    ISSN： 1949-2553

  1389. 膵臓外科領域における内視鏡外科の有用性 当科症例の検討から

    森川 孝則, 高館 達之, 石田 昌玄, 青木 豪, 伊関 雅裕, 前田 晋平, 有明 恭平, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　234-234　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1390. 膵頭十二指腸切除術におけるNCDリスクカリキュレーターの有用性

    水間 正道, 伊関 雅裕, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　237-237　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1391. 膵神経内分泌腫瘍に骨転移との鑑別を要する腸骨リンパ腫が合併したvon Hippel-Lindau病の1例

    客本 ゆき恵, 水間 正道, 前田 晋平, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 阿部 友哉, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　426-426　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1392. 肝門部領域胆管癌におけるgemcitabine補助化学療法の効果検討

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 前田 晋平, 有明 恭平, 石田 晶玄, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　527-527　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1393. 膵臓外科領域における内視鏡外科の有用性 当科症例の検討から

    森川 孝則, 高館 達之, 石田 昌玄, 青木 豪, 伊関 雅裕, 前田 晋平, 有明 恭平, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　234-234　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1394. 膵頭十二指腸切除術におけるNCDリスクカリキュレーターの有用性

    水間 正道, 伊関 雅裕, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　237-237　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1395. 膵神経内分泌腫瘍に骨転移との鑑別を要する腸骨リンパ腫が合併したvon Hippel-Lindau病の1例

    客本 ゆき恵, 水間 正道, 前田 晋平, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 阿部 友哉, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　426-426　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1396. 肝門部領域胆管癌におけるgemcitabine補助化学療法の効果検討

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 前田 晋平, 有明 恭平, 石田 晶玄, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(Suppl.2)　527-527　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1397. 開腹手術での起死回生の一手(肝) 生体肝移植における動脈再建困難例に対するジャンピンググラフトを用いた非解剖学的再建

    中西 渉, 宮城 重人, 中西 史, 原 康之, 宮澤 恒持, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　353-353　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1398. 外科手術での補助器具開発 パルスジェットメスの開発 肝切除術への臨床応用を目指して

    中西 史, 中野 徹, 宮城 重人, 原 康之, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 横沢 友樹, 佐藤 千晃, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　403-403　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1399. ミラノ基準外肝細胞癌初回切除例の検討

    原 康之, 宮城 重人, 中西 史, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　521-521　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1400. 再々発に対して根治手術を施行した後腹膜脂肪肉腫の一例

    笹嶋 秀憲, 原 康之, 宮澤 恒持, 中西 渉, 中西 史, 宮城 重人, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　724-724　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1401. Hybrid手術室でのステントグラフト内挿術と胆嚢摘出術の同時手術

    齋藤 純健, 原 康之, 宮澤 恒持, 中西 渉, 中西 史, 宮城 重人, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　743-743　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1402. 右心房内腫瘍栓を伴う横隔膜再発肝細胞癌の一切除例

    太田 嶺人, 中西 史, 宮城 重人, 原 康之, 中西 渉, 宮澤 恒持, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　908-908　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1403. 肝切除におけるEnhanced Recovery After Surgery(ERAS)の有効性についての介入研究

    中西 渉, 宮城 重人, 中西 史, 戸子台 和哲, 原 康之, 宮澤 恒持, 清水 健司, 海野 倫明, 亀井 尚

    日本消化器外科学会雑誌　50　(Suppl.2)　508-508　2017/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1404. 開胸開腹手術での起死回生の一手(食道) 食道切除後、気道壊死に対する有茎性大網充填術の有用性

    櫻井 直, 谷山 裕亮, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 石田 裕嵩, 小野寺 優, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　339-339　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1405. 内視鏡下手術での起死回生の一手(食道) 腹臥位胸腔鏡下食道切除術における左下肺静脈損傷のピットフォールと対応・予防策

    谷山 裕亮, 桜井 直, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 小野寺 優, 石田 裕嵩, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　344-344　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1406. 食道・胃癌術前補助療法CR症例[手術vs経過観察] 食道癌術前補助療法Clinical Complete Response(CR)判定の適中率の検討

    瓶子 隆弘, 小野寺 優, 石田 裕嵩, 丸山 祥太, 岡本 宏史, 佐藤 千晃, 櫻井 直, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　355-355　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1407. 食道癌補助療法後の至適郭清[3領域vs2領域] 術前化学療法後食道癌手術における頸部郭清の意義についての検討

    岡本 宏史, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 丸山 祥太, 石田 裕嵩, 小野寺 優, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　372-372　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1408. 当科における胸腔鏡下食道切除術の手術手技と治療成績

    櫻井 直, 谷山 裕亮, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 小野寺 優, 石田 裕嵩, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　485-485　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1409. Salvage食道切除術における安全性の追求 16年103例の経験から

    谷山 裕亮, 桜井 直, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 小野寺 優, 石田 裕嵩, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　514-514　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1410. 食道破裂が疑われた食道裂孔ヘルニアを伴う胃潰瘍穿孔の一例

    小野寺 優, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 石田 裕嵩, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　78　(増刊)　782-782　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1411. 破骨細胞様巨細胞を伴った肝血管肉腫の1例

    水井 崇浩, 村上 圭吾, 原 康之, 宮城 重人, 中西 史, 中西 渉, 宮澤 恒持, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　576-576　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1412. Animal ethics and welfare education in wet-lab training can foster residents' ethical values toward life Peer-reviewed

    Yuko Iki, Takuya Ito, Katsuyoshi Kudo, Masafumi Noda, Masahiko Kanehira, Teruko Sueta, Ichiro Miyoshi, Yutaka Kagaya, Yoshinori Okada, Michiaki Unno

    EXPERIMENTAL ANIMALS　66　(4)　313-320　2017/10

    DOI： 10.1538/expanim.17-0026 　

    ISSN： 1341-1357

    eISSN： 1881-7122

  1413. 十二指腸狭窄を伴う慢性膵炎に対して膵頭十二指腸切除術と膵管空腸側々吻合術を併施した1例

    佐藤 英昭, 石田 晶玄, 岡田 恭穂, 元井 冬彦, 坂田 直昭, 青木 豪, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 海野 倫明

    膵臓　32　(5)　836-842　2017/10

    Publisher: 日本膵臓学会

    DOI： 10.2958/suizo.32.836 　

    ISSN： 0913-0071

    eISSN： 1881-2805

  1414. Pancreatic neuroendocrine tumor with complete replacement of the pancreas by serous cystic neoplasms in a patient with von Hippel-Lindau disease: a case report. International-journal Peer-reviewed

    Shimpei Maeda, Fuyuhiko Motoi, Shuhei Oana, Kyohei Ariake, Masamichi Mizuma, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Takashi Kamei, Takeshi Naitoh, Michiaki Unno

    Surgical case reports　3　(1)　105-105　2017/09/25

    DOI： 10.1186/s40792-017-0381-4 　

    More details Close

    BACKGROUND: von Hippel-Lindau disease is a dominantly inherited multi-system syndrome with neoplastic hallmarks. Pancreatic lesions associated with von Hippel-Lindau include serous cystic neoplasms, simple cysts, and neuroendocrine tumors. The combination of pancreatic neuroendocrine tumors and serous cystic neoplasms is relatively rare, and the surgical treatment of these lesions must consider both preservation of pancreatic function and oncological clearance. We report a patient with von Hippel-Lindau disease successfully treated with pancreas-sparing resection of a pancreatic neuroendocrine tumor where the pancreas had been completely replaced by serous cystic neoplasms, in which pancreatic function was preserved. CASE PRESENTATION: A 39-year-old female with von Hippel-Lindau disease was referred to our institution for treatment of a pancreatic neuroendocrine tumor. Abdominal computed tomography demonstrated a well-enhanced mass, 4 cm in diameter in the tail of the pancreas, and two multilocular tumors with several calcifications, 5 cm in diameter, in the head of the pancreas. There was complete replacement of the pancreas by multiple cystic lesions with diameters ranging from 1 to 3 cm. Magnetic resonance cholangiopancreatography showed innumerable cystic lesions on the whole pancreas and no detectable main pancreatic duct. Endoscopic ultrasound-guided fine-needle aspiration of the mass in the pancreatic tail showed characteristic features of a neuroendocrine tumor. A diagnosis of pancreatic neuroendocrine tumor in the tail of the pancreas and mixed-type serous cystic neoplasms replacing the whole pancreas was made and she underwent distal pancreatectomy while avoiding total pancreatectomy. The stump of the pancreas was sutured as firm as possible using a fish-mouth closure. The patient made a good recovery and was discharged on postoperative day 9. She is currently alive and well with no symptoms of endocrine or exocrine pancreatic insufficiency 8 months after surgery. CONCLUSIONS: A pancreas-sparing resection should be considered for patients with pancreatic neuroendocrine tumors and complete cystic replacement of the pancreas to preserve quality of life after surgery.

  1415. Renoportal Anastomosis in Left Lateral Lobe Living Donor Liver Transplantation: A Pediatric Case Peer-reviewed

    Hiroyuki Ogasawara, Chikashi Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Yasuyuki Hara, Wataru Nakanishi, Koji Miyazawa, Kenji Shimizu, Hiroyuki Kumata, Hitoshi Goto, Masafumi Goto, Michiaki Unno, Takashi Kamei

    Case Reports in Gastroenterology　11　(3)　584-592　2017/09/06

    Publisher: S. Karger AG

    DOI： 10.1159/000481160 　

    ISSN： 1662-0631

  1416. 抗癌剤感受性の増強を目指したP-glycoproteinに対する新規抑制剤の開発

    杉沢 徳彦, 大沼 忍, 村上 恵, 海野 倫明

    日本癌学会総会記事　76回　P-1371　2017/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1417. Developing better practices at the institutional level leads to better outcomes after pancreaticoduodenectomy in 3,378 patients: domestic audit of the Japanese Society of Pancreatic Surgery Peer-reviewed

    Sohei Satoi, Tomohisa Yamamoto, Hideyuki Yoshitomi, Fuyuhiko Motoi, Manabu Kawai, Tsutomu Fujii, Keita Wada, Hidehito Arimitsu, Masayuki Sho, Ippei Matsumoto, Satoshi Hirano, Hiroaki Yanagimoto, Masayuki Ohtsuka, Michiaki Unno, Hiroki Yamaue, Masanori Kon

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　24　(9)　501-510　2017/09

    DOI： 10.1002/jhbp.492 　

    ISSN： 1868-6974

    eISSN： 1868-6982

  1418. Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration Peer-reviewed

    Takayuki Miura, Masanori Tachikawa, Hideo Ohtsuka, Koji Fukase, Shun Nakayama, Naoaki Sakata, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Yasuo Uchida, Sumio Ohtsuki, Tetsuya Terasaki, Michiaki Unno

    JOURNAL OF PHARMACEUTICAL SCIENCES　106　(9)　2499-2508　2017/09

    DOI： 10.1016/j.xphs.2017.02.018 　

    ISSN： 0022-3549

    eISSN： 1520-6017

  1419. miRNAによる膵全摘自家膵島移植に対する新規予後予測バイオマーカーの探索

    吉松 軍平, 坂田 直昭, 西中村 瞳, 松岡 泰祐, 高橋 宏幸, Naziruddin Bashoo, 海野 倫明, 小玉 正太

    移植　52　(総会臨時)　402-402　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1420. 小児移植におけるtransitional(移行期)ケアのあり方 小児肝移植後成人移行症例における精神的問題を含めた諸問題

    中西 史, 宮城 重人, 戸子台 和哲, 原 康之, 中西 渉, 齋藤 尚子, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　267-267　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1421. 灌流臓器保存の現状と将来 心停止下摘出肝グラフトに対する酸素化灌流の臓器保存効果

    柿崎 裕太, 宮城 重人, 清水 健司, 米田 海, 熊田 博之, 松村 宗幸, 宮崎 勇希, 福岡 健吾, 植松 智海, 原 康之, 中西 史, 海野 倫明, 亀井 尚, 後藤 昌史

    移植　52　(総会臨時)　282-282　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1422. 膵臓移植:マージナルドナーの適応と限界 当院におけるマージナルドナー膵腎移植の現状

    宮城 重人, 中西 史, 原 康之, 戸子台 和哲, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　293-293　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1423. 当科肝移植患者におけるPTLDの検討

    宮城 重人, 中西 史, 原 康之, 戸子台 和哲, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　352-352　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1424. 生体肝移植後腎機能と長期予後ついての検討

    中西 史, 宮城 重人, 戸子台 和哲, 原 康之, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　514-514　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1425. Tumor-Targeting Salmonella typhimurium A1-R Sensitizes Melanoma With a BRAF-V600E Mutation to Vemurafenib in a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Ming Zhao, Yong Zhang, Bartosz Chmielowski, Tasuku Kiyuna, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Michiaki Unno, Fritz C. Eilber, Robert M. Hoffman

    JOURNAL OF CELLULAR BIOCHEMISTRY　118　(8)　2314-2319　2017/08

    DOI： 10.1002/jcb.25886 　

    ISSN： 0730-2312

    eISSN： 1097-4644

  1426. Impact of the Trough Level of Calcineurin Inhibitor on the Prevalence of Donor-Specific Human Leukocyte Antigen Antibodies During Long-Term Follow-Up After Pediatric Liver Transplantation: Antibody Strength and Complement-Binding Ability. International-journal Peer-reviewed

    Tokodai K, Miyagi S, Nakanishi C, Hara Y, Nakanishi W, Goto M, Unno M, Kamei T

    Transplantation direct　3　(8)　e196　2017/08

    DOI： 10.1097/TXD.0000000000000713 　

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    BACKGROUND: In pediatric patients, long-term immunosuppression after liver transplantation (LT) is typically minimal. However, posttransplant donor-specific HLA antibodies (DSAs) may be prevalent under these conditions. Here, we evaluated the effects of minimized calcineurin inhibitor (CNI) on DSA development to assess the validity of minimized/withdrawn immunosuppression. METHODS: We retrospectively examined 66 patients who underwent pediatric LT at our institution between July 1991 and October 2013. Patients were divided into 2 groups based on the CNI trough level. The cutoff trough levels were 3 and 30 ng/mL for tacrolimus and cyclosporine, respectively. Luminex single-antigen bead assays were performed, and the cutoff for a positive reaction was set at a mean fluorescence intensity (MFI) of at least 1000. RESULTS: The mean recipient ages at the time of LT were 29.1 and 77.2 months for the low and regular CNI groups, respectively (P = 0.0007). Univariate logistic regression analysis revealed that recipient age at LT younger than 3 years (P = 0.0099) and low CNI (P < 0.0001) were significantly associated with DSA development. In multivariate analysis, low CNI was an independent risk factor of DSA development (P = 0.0011). Of 15 high-MFI DSAs, 3 were anti-DR, and 12 were anti-DQ. Two of 3 anti-DR DSAs and 11 of 12 anti-DQ DSAs had complement-binding ability and high MFIs. CONCLUSIONS: CNI minimization was an independent risk factor for posttransplant DSA during long-term follow-up after pediatric LT. Adjusting CNI to appropriate levels is a safe first step to prevent the immunological effects of DSA.

  1427. Surgical technique and long-term outcome of major vessel resection for perihilar cholangiocarcinoma

    深瀬 耕二, 伊関 雅裕, 高舘 達之, 益田 邦洋, 中川 圭, 元井 冬彦, 海野 倫明

    外科 = Surgery : 臨床雑誌　79　(8)　720-724　2017/08

    Publisher: 南江堂

    DOI： 10.15106/J00393.2017324285 　

    ISSN： 0016-593X

  1428. 自然破裂により発症した膵粘液性嚢胞腫瘍の1例

    客本 ゆき恵, 水間 正道, 石田 晶玄, 橘 知睦, 伊関 雅裕, 高舘 達之, 阿部 友哉, 大塚 英郎, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 佐藤 聡子, 藤島 史喜, 菅野 敦, 下瀬川 徹, 海野 倫明

    膵臓　32　(4)　767-774　2017/08

    Publisher: 日本膵臓学会

    DOI： 10.2958/suizo.32.767 　

    ISSN： 0913-0071

    eISSN： 1881-2805

  1429. 胆管内乳頭状腫瘍(IPNB)に対する診断、手術適応と至適術式 胆管内乳頭状腫瘍(IPNB)を粘液産生の有無で区別する臨床的意義

    水間 正道, 森川 孝則, 高舘 達之, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　WS07-5　2017/07

    Publisher: (一社)日本消化器外科学会

  1430. 摘出膵臓の硬度変化から見た膵全摘自家膵島移植における移植成績の影響について

    吉松 軍平, 坂田 直昭, 伊東 威, Naziruddin Bashoo, 海野 倫明, 小玉 正太

    日本消化器外科学会総会　72回　PK12-2　2017/07

    Publisher: (一社)日本消化器外科学会

  1431. LRRFIP1発現抑制膵癌細胞におけるJNKを介したアポトーシス誘導とゲムシタビン感受性変化の検討

    川崎 修平, 大塚 英郎, 堂地 大輔, 有明 恭平, 益田 邦洋, 深瀬 耕二, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PK1-5　2017/07

    Publisher: (一社)日本消化器外科学会

  1432. 膵癌術前治療における骨格筋量の変化と予後 Invited

    志村 充広, 水間 正道, 元井 冬彦, 海野 倫明

    肝・胆・膵　75　(1)　93-99　2017/07

  1433. MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX) Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Tasuku Kiyuna, Thinzar M. Lwin, Ho Kyoung Hwang, Jonathan C. Delong, Bryan M. Clary, Michael Bouvet, Michiaki Unno, Robert M. Hoffman

    ONCOTARGET　8　(29)　47490-47496　2017/07

    DOI： 10.18632/oncotarget.17667 　

    ISSN： 1949-2553

  1434. 【十二指腸乳頭部癌-現状の問題点と今後の展望-】 乳頭部癌の術前リンパ節転移診断 Peer-reviewed

    伊関 雅裕, 中川 圭, 海野 倫明

    胆と膵　38　(7)　673-677　2017/07

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1435. Synthetic analogs of curcumin as modulators of multidrug resistance-linked ABC transporters Peer-reviewed

    Obara Megumi, Ohnuma Shinobu, Chufan Eduardo E, Ishida Masaharu, Kudoh Katsuyoshi, Sugisawa Norihiko, Ohtsuka Hideo, Naitoh Takeshi, Shibata Hiroyuki, Iwabuchi Yoshiharu, Ambudkar Suresh V, Unno Michiaki

    CANCER RESEARCH　77　2017/07

    DOI： 10.1158/1538-7445.AM2017-3242 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1436. The Optimization of Short-Term Hepatocyte Preservation Before Transplantation. International-journal Peer-reviewed

    Fukuoka K, Inagaki A, Nakamura Y, Matsumura M, Yoshida S, Imura T, Igarashi Y, Miyagi S, Ohashi K, Enosawa S, Kamei T, Unno M, Ohuchi N, Satomi S, Goto M

    Transplantation direct　3　(7)　e176　2017/07

    DOI： 10.1097/TXD.0000000000000687 　

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    BACKGROUND: No optimal methods for short-term hepatocyte preservation have been established. We have recently developed a prominent oxygen-permeable bag (Tohoku Device [TD]) for pancreatic islet culture and transplantation. In this study, we investigated whether TD is also effective for hepatocyte preservation and tried to optimize other conditions. METHODS: Hepatocytes were preserved in the following conditions, and their outcomes were observed. First, the effectiveness of TD was investigated. Second, hepatocyte medium (HM) and organ preservation solutions with or without fetal bovine serum (FBS) were compared. Third, as supplementations, FBS and human serum albumin (HSA) were compared. Fourth, low, room and high temperature were compared. And finally, hepatocytes preserved in various conditions were transplanted into the subrenal capsule space of nonalbumin rats and engrafted areas were assessed. RESULTS: The survival rate of hepatocytes preserved in TD tended to be higher and their viability and function were maintained significantly greater than those of non-TD group. Irrespective of FBS supplementation, the survival rate of HM group was significantly higher than those of organ preservation solution group while viabilities and plating efficiency were similar among them. Although survival rates of groups without FBS were extremely low, results of HSA supplemented group were not inferior to FBS supplemented group. Hepatocytes preserved at high temperature had the worst results. The engrafted area of TD group tended to be higher than those of other groups. CONCLUSIONS: TD is effective for short-term hepatocyte preservation. HSA is a useful substitute for FBS, and preserving in HM at low temperature is recommended.

  1437. Effect of Recipient Age at Liver Transplantation on Prevalence of Post-Transplant Donor-Specific HLA Antibody Peer-reviewed

    Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Michiaki Unno, Takashi Kamei

    ANNALS OF TRANSPLANTATION　22　2017/06

    DOI： 10.12659/AOT.903926 　

    ISSN： 1425-9524

  1438. 胆管炎の移植膵島に対する影響とそのメカニズム． Invited Peer-reviewed

    坂田直昭, 海野倫明

    胆膵の病態生理　33　(1)　25-28　2017/06

    Publisher:

    ISSN： 2185-4564

  1439. p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation. International-journal Peer-reviewed

    Nakayama S, Karasawa H, Suzuki T, Yabuuchi S, Takagi K, Aizawa T, Onodera Y, Nakamura Y, Watanabe M, Fujishima F, Yoshida H, Morikawa T, Sase T, Naitoh T, Unno M, Sasano H

    Cancer medicine　6　(6)　1264-1274　2017/06

    DOI： 10.1002/cam4.1093 　

    More details Close

    p62/sequestosome 1 (p62) is a multi-domain protein that functions as a receptor for ubiquitinated targets in the selective autophagy and serves as a scaffold in various signaling cascades. p62 have been reported to be up-regulated in several human malignancies, but the biological roles and significance of p62 are still poorly understood in colorectal carcinoma. We immunohistochemically evaluated p62 in 118 colorectal adenocarcinoma and 28 colorectal adenoma cases. We used four colon carcinoma cells (HCT8, HT29, COLO320, and SW480) in the in vitro studies. p62 immunoreactivity was detected in 11% of colorectal adenoma cases and 31% of adenocarcinoma cases, while it was negligible in the normal epithelium. The immunohistochemical p62 status was significantly associated with synchronous liver metastasis, and it turned out to be an independent adverse prognostic factor in colorectal cancer patients. Following in vitro studies revealed that HCT8 and HT29 cells transfected with p62-specific siRNA showed significantly decreased cell proliferation activity, whereas COLO320 and SW480 cells transfected with p62 expression plasmid showed significantly increased cell proliferation activity. The p62-mediated cell proliferation was not associated with the autophagy activity. These findings suggest that p62 promotes the cell proliferation mainly as a scaffold protein, and that the p62 status is a potent prognostic factor in colorectal carcinoma patients.

  1440. [Surgical Training Utilizing Swine Under General Anesthesia and Animal Ethics]. Peer-reviewed

    Iki Y, Noda M, Kudoh K, Sueta T, Kanehira M, Ito T, Matsuda Y, Okada Y, Unno M

    Kyobu geka. The Japanese journal of thoracic surgery　70　(5)　329-333　2017/05

    Publisher:

    ISSN： 0021-5252

  1441. Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics Peer-reviewed

    Yoshihiro Sato, Yasutake Katoh, Mitsuyo Matsumoto, Masaki Sato, Masayuki Ebina, Ari Itoh-Nakadai, Ryo Funayama, Keiko Nakayama, Michiaki Unno, Kazuhiko Igarashi

    JOURNAL OF BIOLOGICAL CHEMISTRY　292　(19)　8019-+　2017/05

    DOI： 10.1074/jbc.M116.774547 　

    ISSN： 0021-9258

    eISSN： 1083-351X

  1442. Safety-related outcomes of the Japanese Society of Hepato-Biliary-Pancreatic Surgery board certification system for expert surgeons Peer-reviewed

    Takehito Otsubo, Shinjiro Kobayashi, Keiji Sano, Takeyuki Misawa, Takehiro Ota, Satoshi Katagiri, Katsuhiko Yanaga, Hiroki Yamaue, Norihiro Kokudo, Michiaki Unno, Jiro Fujimoto, Fumihiko Miura, Masaru Miyazaki, Masakazu Yamamoto

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　24　(5)　252-261　2017/05

    DOI： 10.1002/jhbp.444 　

    ISSN： 1868-6974

    eISSN： 1868-6982

  1443. All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase Peer-reviewed

    Hiroki Kuroda, Masanori Tachikawa, Yasuo Uchida, Koetsu Inoue, Hideo Ohtsuka, Sumio Ohtsuki, Michiaki Unno, Tetsuya Terasaki

    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES　103　116-121　2017/05

    DOI： 10.1016/j.ejps.2017.02.021 　

    ISSN： 0928-0987

    eISSN： 1879-0720

  1444. 肝動脈変異症例に対する肝門部領域胆管癌手術 (特集 解剖学的変異を考慮した肝胆膵外科手術)

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 元井 冬彦, 海野 倫明

    手術 = Operation　71　(6)　845-852　2017/05

    Publisher: 金原出版

    ISSN： 0037-4423

  1445. 【胆膵腫瘍に対する術前治療と切除前後の効果判定法】 切除企図膵癌に対する術前治療と効果判定・有効性評価

    元井 冬彦, 伊関 雅裕, 有明 恭平, 高館 達之, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 森川 孝則, 中川 圭, 内藤 剛, 海野 倫明

    胆と膵　38　(5)　471-479　2017/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1446. Risk factors of serious postoperative complications after pancreaticoduodenectomy and risk calculators for predicting postoperative complications: a nationwide study of 17,564 patients in Japan Peer-reviewed

    Shuichi Aoki, Hiroaki Miyata, Hiroyuki Konno, Mitsukazu Gotoh, Fuyuhiko Motoi, Hiraku Kumamaru, Go Wakabayashi, Yoshihiro Kakeji, Masaki Mori, Yasuyuki Seto, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　24　(5)　243-251　2017/05

    DOI： 10.1002/jhbp.438 　

    ISSN： 1868-6974

    eISSN： 1868-6982

  1447. Bile acid and colorectal cancer Peer-reviewed

    Michiaki Unno

    Bile Acids in Gastroenterology: Basic and Clinical　185-192　2017/04/03

    Publisher: Springer Japan

    DOI： 10.1007/978-4-431-56062-3_14 　

  1448. 難治性慢性膵炎に対する膵全摘自家膵島移植における再建術式の検討 Pylorus温存vs非温存 Baylor University Medical Centerにおける83例の検討

    吉松 軍平, 坂田 直昭, Shahbazov Rauf, 伊東 威, Naziruddin Bashoo, Levy Marlon F., 海野 倫明, 小玉 正太

    日本外科学会定期学術集会抄録集　117回　PS-8　2017/04

    Publisher: (一社)日本外科学会

  1449. Randomized clinical trial of duct-to-mucosa pancreaticogastrostomy versus handsewn closure after distal pancreatectomy Peer-reviewed

    K. Uemura, S. Satoi, F. Motoi, M. Kwon, M. Unno, Y. Murakami

    British Journal of Surgery　104　(5)　536-543　2017/04/01

    Publisher: John Wiley and Sons Ltd

    DOI： 10.1002/bjs.10458 　

    ISSN： 1365-2168 0007-1323

  1450. Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination Peer-reviewed

    Ryo Funayama, Hajime Taniguchi, Masamichi Mizuma, Fumiyoshi Fujishima, Minoru Kobayashi, Shinobu Ohnuma, Michiaki Unno, Keiko Nakayama

    CANCER SCIENCE　108　(4)　713-718　2017/04

    DOI： 10.1111/cas.13179 　

    ISSN： 1349-7006

  1451. 【先天性胆道拡張症の最前線】 先天性胆道拡張症術後の肝内結石 Peer-reviewed

    大塚 英郎, 森川 孝則, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    胆と膵　38　(4)　401-406　2017/04

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1452. Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers Peer-reviewed

    Michiko Yamaki, Hiroki Saito, Kunio Isono, Tomoko Goto, Hitoshi Shirakawa, Noriaki Shoji, Shizuko Satoh-Kuriwada, Takashi Sasano, Ryo Okada, Katsuyoshi Kudoh, Fuyuhiko Matoi, Michiaki Unno, Michio Komai

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　63　(2)　148-154　2017/04

    DOI： 10.3177/jnsv.63.148 　

    ISSN： 0301-4800

    eISSN： 1881-7742

  1453. Kindlin-2 in pancreatic stellate cells promotes the progression of pancreatic cancer Peer-reviewed

    Naoki Yoshida, Atsushi Masamune, Shin Hamada, Kazuhiro Kikuta, Tetsuya Takikawa, Fuyuhiko Motoi, Michiaki Unno, Tooru Shimosegawa

    CANCER LETTERS　390　103-114　2017/04

    DOI： 10.1016/j.canlet.2017.01.008 　

    ISSN： 0304-3835

    eISSN： 1872-7980

  1454. MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells Peer-reviewed

    Koetsu Inoue, Hideo Ohtsuka, Masanori Tachikawa, Fuyuhiko Motoi, Masahiro Shijo, Daisuke Douchi, Shuhei Kawasaki, Kei Kawaguchi, Kunihiro Masuda, Koji Fukase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Tetsuya Terasaki

    PANCREAS　46　(4)　557-566　2017/04

    DOI： 10.1097/MPA.0000000000000778 　

    ISSN： 0885-3177

    eISSN： 1536-4828

  1455. Protein-arginine deiminase 2 suppresses proliferation of colon cancer cells through protein citrullination. Peer-reviewed

    Funayama R, Taniguchi H, Mizuma M, Fujishima F, Kobayashi M, Ohnuma S, Unno M, Nakayama K

    Cancer science　108　(4)　713-718　2017/04

    DOI： 10.1111/cas.13179 　

    ISSN： 1347-9032

  1456. Hexokinase 2 in colorectal cancer: a potent prognostic factor associated with glycolysis, proliferation and migration. International-journal Peer-reviewed

    Katagiri M, Karasawa H, Takagi K, Nakayama S, Yabuuchi S, Fujishima F, Naitoh T, Watanabe M, Suzuki T, Unno M, Sasano H

    Histology and histopathology　32　(4)　351-360　2017/04

    DOI： 10.14670/HH-11-799 　

    ISSN： 0213-3911

    More details Close

    BACKGROUND: It is well known that proliferating carcinoma cells preferentially use aerobic glycolysis rather than oxidative phosphorylation for energy production. Hexokinase 2 (HK2) plays a pivotal role in the glycolytic pathway. Previous studies have demonstrated that HK2 activity is markedly increased in various malignant neoplasms, but the clinical and biological significance of HK2 remain largely unclear in the colorectal carcinoma. PATIENTS AND METHODS: We performed immunohistochemistry for HK2 in 195 colorectal carcinoma tissues. We also used HCT8 and HT29 colon carcinoma cells in in vitro studies. RESULTS: HK2 immunoreactivity was detected in 100 out of 195 (51%) colorectal carcinoma tissues, and the immunohistochemical HK2 status was significantly associated with tumor size, depth of invasion, liver metastasis and TNM stage in these cases. Moreover, the HK2 status was significantly associated with increased incidence of recurrence and overall mortality of the patients, and multivariate analyses demonstrated that HK2 status was an independent prognostic factor for both disease-free and overall survival. Subsequent in vitro experiments revealed that both HCT8 and HT29 colon carcinoma cells transfected with specific siRNA for HK2 significantly decreased the lactate production, proliferation activity and migration property. CONCLUSION: These results suggest that HK2 plays important roles in the glycolytic, proliferation and migration properties of colorectal carcinoma and, therefore, HK2 status is a potent worse prognostic factor in colorectal cancer patients.

  1457. High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models Peer-reviewed

    Kei Kawaguchi, Takashi Murakami, Atsushi Suetsugu, Tasuku Kiyuna, Kentaro Igarashi, Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Michael Bouvet, Bryan M. Clary, Michiaki Unno, Robert M. Hoffman

    ONCOTARGET　8　(12)　19065-19073　2017/03

    DOI： 10.18632/oncotarget.12227 　

    ISSN： 1949-2553

  1458. 【超高齢者(80歳以上)の胆膵疾患診療を考える】 高齢者膵癌に対する外科治療戦略

    元井 冬彦, 伊関 雅裕, 有明 恭平, 高館 達之, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 森川 孝則, 中川 圭, 内藤 剛, 海野 倫明

    胆と膵　38　(3)　273-278　2017/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1459. Wisteria floribunda agglutinin- sialylated mucin core polypeptide 1 is a sensitive biomarker for biliary tract carcinoma and intrahepatic cholangiocarcinoma: a multicenter study Peer-reviewed

    Junichi Shoda, Atsushi Matsuda, Takashi Shida, Masakazu Yamamoto, Masato Nagino, Toshio Tsuyuguchi, Takahiro Yasaka, Susumu Tazuma, Kazuhisa Uchiyama, Michiaki Unno, Nobuaki Ohkohchi, Yasuni Nakanuma, Atsushi Kuno, Hisashi Narimatsu

    JOURNAL OF GASTROENTEROLOGY　52　(2)　218-228　2017/02

    DOI： 10.1007/s00535-016-1230-0 　

    ISSN： 0944-1174

    eISSN： 1435-5922

  1460. Multicenter Phase II Study of Intravenous and Intraperitoneal Paclitaxel With S-1 for Pancreatic Ductal Adenocarcinoma Patients With Peritoneal Metastasis Peer-reviewed

    Sohei Satoi, Tsutomu Fujii, Hiroaki Yanagimoto, Fuyuhiko Motoi, Masanao Kurata, Naminatsu Takahara, Suguru Yamada, Tomohisa Yamamoto, Masamichi Mizuma, Goro Honda, Hiroyuki Isayama, Michiaki Unno, Yasuhiro Kodera, Hironori Ishigami, Masanori Kon

    ANNALS OF SURGERY　265　(2)　397-401　2017/02

    DOI： 10.1097/SLA.0000000000001705 　

    ISSN： 0003-4932

    eISSN： 1528-1140

  1461. National Clinical Database(消化器外科領域) Annual Report 2015

    掛地 吉弘, 宇田川 晴司, 海野 倫明, 遠藤 格, 國崎 主税, 武冨 紹信, 丹黒 章, 正木 忠彦, 丸橋 繁, 吉田 和弘, 渡邉 聡明, 後藤 満一, 今野 弘之, 高橋 新, 宮田 裕章, 瀬戸 泰之, 一般社団法人National, Clinical Database

    日本消化器外科学会雑誌　50　(2)　166-176　2017/02

    Publisher: (一社)日本消化器外科学会

    DOI： 10.5833/jjgs.2017.sr001 　

    ISSN： 0386-9768

    eISSN： 1348-9372

  1462. NDRG2, suppressed expression associates with poor prognosis in pancreatic cancer, is hypermethylated in the second promoter in human gastrointestinal cancers. International-journal Peer-reviewed

    Yamamura A, Miura K, Karasawa H, Motoi F, Mizuguchi Y, Saiki Y, Fukushige S, Sunamura M, Shibata C, Unno M, Horii A

    Biochemical and biophysical research communications　484　(1)　138-143　2017/02

    DOI： 10.1016/j.bbrc.2017.01.055 　

    ISSN： 0006-291X

    More details Close

    Although N-myc downstream regulated gene 2 (NDRG2) is frequently downregulated in various cancers and is considered to be a candidate tumor suppressor gene, molecular mechanisms of the expressional suppression that lead to cancers are largely unknown. Recent studies indicated that epigenetic suppression of NDRG2 involved carcinogenesis and progression in several tumor types, and we demonstrated positive association with NDRG2 suppression and poor prognosis in pancreatic cancer. In this study, we analyzed mRNA and protein expressions of NDRG2 in 26 cancer cell lines (20 colorectal and 6 gastric cancers) and found that many cell lines showed variously reduced NDRG2 expressions. Furthermore, NDRG2 expressions were significantly reduced in primary resected cancer tissues compared to corresponding normal tissues immunohistochemically (19 of 20 colorectal and 14 of 17 gastric cancers). Treatment with 5-Aza-2' deoxycytidine predominantly upregulated NDRG2 expressions in NDRG2 low-expressing cell lines. Bisulfite sequencing analyses and methylation specific PCR revealed that methylation status at one of the two promoters (around exon 2) correlated well with the suppressed expression, and this is the major promoter in colorectal and gastric cancer cell lines. Our present results suggest that hypermethylation in promoter around exon 2 is functioning as essential factors of NDRG2 silencing in gastrointestinal cancers.

  1463. Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice Peer-reviewed

    Junichi Matsuo, Shunichi Kimura, Akihiro Yamamura, Cai Ping Koh, Md Zakir Hossain, Dede Liana Heng, Kazuyoshi Kohu, Dominic Chih-Cheng Voon, Hiroshi Hiai, Michiaki Unno, Jimmy Bok Yan So, Feng Zhu, Supriya Srivastava, Ming Teh, Khay Guan Yeoh, Motomi Osato, Yoshiaki Ito

    GASTROENTEROLOGY　152　(1)　218-+　2017/01

    DOI： 10.1053/j.gastro.2016.09.018 　

    ISSN： 0016-5085

    eISSN： 1528-0012

  1464. Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. International-journal Peer-reviewed

    Yamamura A, Miura K, Karasawa H, Morishita K, Abe K, Mizuguchi Y, Saiki Y, Fukushige S, Kaneko N, Sase T, Nagase H, Sunamura M, Motoi F, Egawa S, Shibata C, Unno M, Sasaki I, Horii A

    Biochem Biophys Res Commun.　441　(1)　102-107　2017

    DOI： 10.1016/j.bbrc.2013.10.010 　

    More details Close

    Pancreatic cancer is a highly lethal disease with a poor prognosis; the molecular mechanisms of the development of this disease have not yet been fully elucidated. N-myc downstream regulated gene 2 (NDRG2), one of the candidate tumor suppressor genes, is frequently downregulated in pancreatic cancer, but there has been little information regarding its expression in surgically resected pancreatic cancer specimens. We investigated an association between NDRG2 expression and prognosis in 69 primary resected pancreatic cancer specimens by immunohistochemistry and observed a significant association between poor prognosis and NDRG2-negative staining (P=0.038). Treatment with trichostatin A, a histone deacetylase inhibitor, predominantly up-regulated NDRG2 expression in the NDRG2 low-expressing cell lines (PANC-1, PCI-35, PK-45P, and AsPC-1). In contrast, no increased NDRG2 expression was observed after treatment with 5-aza-2' deoxycytidine, a DNA demethylating agent, and no hypermethylation was detected in either pancreatic cancer cell lines or surgically resected specimens by methylation specific PCR. Our present results suggest that (1) NDRG2 is functioning as one of the candidate tumor-suppressor genes in pancreatic carcinogenesis, (2) epigenetic mechanisms such as histone modifications play an essential role in NDRG2 silencing, and (3) the expression of NDRG2 is an independent prognostic factor in pancreatic cancer.

  1465. Combination of gemcitabine and docetaxel regresses both gastric leiomyosarcoma proliferation and invasion in an imageable patient-derived orthotopic xenograft (iPDOX) model Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Tasuku Kiyuna, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Tara A. Russell, Arun S. Singh, Bartosz Chmielowski, Michiaki Unno, Fritz C. Eilber, Robert M. Hoffman

    CELL CYCLE　16　(11)　1063-1069　2017

    DOI： 10.1080/15384101.2017.1314406 　

    ISSN： 1538-4101

    eISSN： 1551-4005

  1466. Salmonella typhimurium A1-R targeting of a chemotherapy-resistant BRAF-V600E melanoma in a patient-derived orthotopic xenograft (PDOX) model is enhanced in combination with either vemurafenib or temozolomide Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Tasuku Kiyuna, Ming Zhao, Yong Zhang, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Arun S. Singh, Bartosz Chmielowski, Yunfeng Li, Michiaki Unno, Fritz C. Eilber, Robert M. Hoffman

    CELL CYCLE　16　(13)　1288-1294　2017

    DOI： 10.1080/15384101.2017.1314420 　

    ISSN： 1538-4101

    eISSN： 1551-4005

  1467. A Giant Intraductal Papillary Mucinous Neoplasm of the Pancreas Which Was Resectable by Cystectomy

    佐藤正規, 深瀬耕二, 有明恭平, 大塚英郎, 村上圭吾, 藤島史喜, 元井冬彦, 内藤剛, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　50　(4)　303‐310(J‐STAGE)-310　2017/01/01

    Publisher: 一般社団法人 日本消化器外科学会

    DOI： 10.5833/jjgs.2016.0147 　

    ISSN： 1348-9372

  1468. Oral rehydration solution normalizes plasma renin and aldosterone levels in patients with ulcerative colitis after proctocolectomy. Peer-reviewed

    Katsuyoshi Kudoh, Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Kenichi Takahashi, Munenori Nagao, Sho Haneda, Kazuhiro Watanabe, Takeshi Naitoh, Michiaki Unno

    Journal of the anus, rectum and colon　1　(3)　78-83　2017

    DOI： 10.23922/jarc.2016-015 　

    More details Close

    OBJECTIVES: The possible effects and benefits of oral rehydration solution (ORS) on chronic dehydration after total proctocolectomy. METHODS: To evaluate the effect of ORS on the renin-angiotensin system after remnant proctocolectomy in patients with ulcerative colitis (UC), we selected 20 patients after remnant proctocolectomy, ileal J pouch-anal anastomosis, and construction of a diverting ileostomy for UC. Patients were randomly divided into two groups, A (n=9) or B (n=11), 2 weeks after the surgery. In group A, ORS (1000 mL/day) was given for the first 7 days and mineral water (1000 mL/day) for the next 7 days. In group B, mineral water (1000 mL/day) was given for the first 7 days and ORS (1000 mL/day) for next 7 days. Plasma levels of renin, aldosterone and excretion of sodium in urine were evaluated at days 0, 7, and 14. We defined day 0 as the day of beginning this study. RESULTS: Mean plasma renin levels on day 0 were six to eight times greater than the upper normal limit. In group A, ORS lowered plasma renin levels. In group B, plasma levels of renin and aldosterone after ORS were lower than those at days 0 and 7. CONCLUSIONS: ORS corrected increased plasma levels of renin and aldosterone to within the normal range in patients after proctocolectomy.

  1469. 手術手技 同時性肝転移を有する膵神経内分泌腫瘍の治療． Invited

    青木 豪, 大塚英郎, 坂田直昭, 内藤 剛, 元井冬彦, 海野倫明

    手術　71　(1)　87-92　2017/01

    ISSN： 0037-4423

  1470. Human Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis Peer-reviewed

    Masahiro Iseki, Yoshihiro Kushida, Shohei Wakao, Takahiro Akimoto, Masamichi Mizuma, Fuyuhiko Motoi, Ryuta Asada, Shinobu Shimizu, Michiaki Unno, Gregorio Chazenbalk, Mari Dezawa

    CELL TRANSPLANTATION　26　(5)　821-840　2017

    DOI： 10.3727/096368916X693662 　

    ISSN： 0963-6897

    eISSN： 1555-3892

  1471. Endovascular Treatment of Hepatic Artery Pseudoaneurysm after Pancreaticoduodenectomy: Risk Factors Associated with Mortality and Complications. Peer-reviewed

    Hasegawa T, Ota H, Matsuura T, Seiji K, Mugikura S, Motoi F, Unno M, Takase K

    Journal of vascular and interventional radiology : JVIR　28　(1)　50-59.e5　2017/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.jvir.2016.04.004 　

    ISSN： 1051-0443

  1472. The Boundary between the Caudate Lobe and the Right Liver: Anatomical Evaluation of Portal and Biliary Branches in the Dorsal Sector Using Multidetector Computed Tomography

    Aoki Shuichi, Unno Michiaki, Mizuma Masamichi, Sakata Naoaki, Otsuka Hideo, Hayashi Hiroki, Nakagawa Kei, Morikawa Takanori, Motoi Fuyuhiko, Naitoh Takeshi

    The Japanese Journal of Gastroenterological Surgery　50　(1)　1-8　2017

    Publisher: The Japanese Society of Gastroenterological Surgery

    ISSN： 0386-9768

  1473. Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductalpapillary mucinous neoplasm and ductal adenocarcinoma. International-journal Peer-reviewed

    Basturk O, Berger MF, Yamaguchi H, Adsay V, Askan G, Bhanot UK, Zehir A, Carneiro F, Hong S-M, Zamboni G, Dikoglu E, Jobanputra V, Wrzeszczynski KO, Balci S, Allen P, Ikari N, Takeuchi S, Akagawa H, Kanno A, Shimosegawa T, Morikawa T, Motoi F, Unno M, Higuchi R, Yamamoto M, Shimizu K, Furukawa T, Klimstra DS

    Mod Pathol　30　(12)　1760-1772　2017

    DOI： 10.1038/modpathol.2017.60 　

    More details Close

    Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. However, the genetic characteristics of intraductal tubulopapillary neoplasm have not been well characterized. Twenty-two intraductal tubulopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (≥300) genes, or whole-exome sequencing. Three of these intraductal tubulopapillary neoplasms were also subjected to whole-genome sequencing. All intraductal tubulopapillary neoplasms revealed the characteristic histologic (cellular intraductal nodules of back-to-back tubular glands lined by predominantly cuboidal cells with atypical nuclei and no obvious intracellular mucin) and immunohistochemical (immunolabeled with MUC1 and MUC6 but were negative for MUC2 and MUC5AC) features. By genomic analyses, there was loss of CDKN2A in 5/20 (25%) of these cases. However, the majority of the previously reported intraductal papillary mucinous neoplasm-related alterations were absent. Moreover, in contrast to most ductal neoplasms of the pancreas, MAP-kinase pathway was not involved. In fact, 2/22 (9%) of intraductal tubulopapillary neoplasms did not reveal any mutations in the tested genes. However, certain chromatin remodeling genes (MLL1, MLL2, MLL3, BAP1, PBRM1, EED, and ATRX) were found to be mutated in 7/22 (32%) of intraductal tubulopapillary neoplasms and 27% harbored phosphatidylinositol 3-kinase (PI3K) pathway (PIK3CA, PIK3CB, INPP4A, and PTEN) mutations. In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion. Intraductal tubulopapillary neoplasm is a distinct clinicopathologic entity in the pancreas. Although its intraductal nature and some clinicopathologic features resemble those of intraductal papillary mucinous neoplasm, our results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics. Some of these mutated genes are potentially targetable. Future functional studies will be needed to determine the consequences of these gene alterations.

  1474. Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage. International-journal Peer-reviewed

    Naoaki Sakata, Yohko Yamaguchi, Yu Chen, Masayuki Shimoda, Gumpei Yoshimatsu, Michiaki Unno, Shoichiro Sumi, Rieko Ohki

    PloS one　12　(11)　e0187927　2017

    DOI： 10.1371/journal.pone.0187927 　

    ISSN： 1932-6203

  1475. Surgical management of chronic pancreatitis Peer-reviewed

    Masaharu Ishida, Fuyuhiko Motoi, Michiaki Unno

    Journal of Japanese Society of Gastroenterology　114　(12)　2118-2124　2017

    Publisher: Japanese Society of Gastroenterology

    DOI： 10.11405/nisshoshi.114.2118 　

    ISSN： 1349-7693 0446-6586

  1476. Wnt-β-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer. Peer-reviewed

    Kobayashi M, Funayama R, Ohnuma S, Unno M, Nakayama K

    Cancer science　107　(12)　1776-1784　2016/12

    DOI： 10.1111/cas.13097 　

    ISSN： 1347-9032

  1477. Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer. Peer-reviewed

    Takahashi Y, Sugai T, Habano W, Ishida K, Eizuka M, Otsuka K, Sasaki A, Takayuki Matsumoto, Morikawa T, Unno M, Suzuki H

    International journal of cancer　139　(11)　2493-2501　2016/12

    DOI： 10.1002/ijc.30377 　

    ISSN： 0020-7136

  1478. 消化器疾患と代謝異常の関わり 膵癌術前治療における骨格筋量の変化と予後に関する検討

    志村 充広, 水間 正道, 海野 倫明

    日本消化器外科学会雑誌　49　(Suppl.2)　100-100　2016/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1479. 皮膚筋炎合併大腸癌の臨床病理学的検討

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　49　(Suppl.2)　187-187　2016/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1480. pNECに対する外科治療の有効性

    元井 冬彦, 青木 豪, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 阿部 友哉, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　49　(Suppl.2)　204-204　2016/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1481. 当教室におけるIPMN併存膵癌切除例の検討

    水間 正道, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 大沼 忍, 武者 宏昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 下瀬川 徹, 海野 倫明

    日本消化器外科学会雑誌　49　(Suppl.2)　205-205　2016/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1482. 腫瘍による多臓器圧排症状が顕著であった巨大Extra-GISTの1切除例

    竹浪 努, 前田 晋平, 唐澤 秀明, 井本 博文, 大沼 忍, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　49　(Suppl.2)　384-384　2016/11

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1483. Tumor-targeting Salmonella typhimurium A1-R combined with temozolomide regresses malignant melanoma with a BRAF-V600E mutation in a patient-derived orthotopic xenograft (PDOX) model Peer-reviewed

    Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Bartosz Chmielowski, Tasuku Kiyuna, Ming Zhao, Yong Zhang, Arun Singh, Michiaki Unno, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Fritz C. Eilber, Robert M. Hoffman

    Oncotarget　7　(52)　2016/11

    Publisher: Impact Journals, {LLC}

    DOI： 10.18632/oncotarget.13231 　

    ISSN： 1949-2553

  1484. Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society. International-journal Peer-reviewed

    Hidetoshi Eguchi, Hiroki Yamaue, Michiaki Unno, Masamichi Mizuma, Shin Hamada, Hisato Igarashi, Tamotsu Kuroki, Sohei Satoi, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshiki Hirooka, Tsutomu Fujii, Atsushi Masamune, Kazuhiro Mizumoto, Takao Itoi, Shinichi Egawa, Yuzo Kodama, Masao Tanaka, Tooru Shimosegawa

    Pancreas　45　(10)　1411-1417　2016/11

    DOI： 10.1097/MPA.0000000000000636 　

    ISSN： 0885-3177

    eISSN： 1536-4828

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    OBJECTIVES: The aim of this study was to determine the characteristics of patients with pancreatic ductal adenocarcinoma younger than 40 years. METHODS: Data from the Japan Pancreas Society's nationwide Pancreatic Cancer Registry were analyzed retrospectively. Clinicopathological characteristics were compared in patients who were grouped according to age, namely, younger than 40 years versus 40 years and older. RESULTS: Of the 36 145 patients in the database, the younger group included 526 (1.5%) patients. A family history of pancreatic cancer was not more frequent in the younger group. The frequency of Union Internationale Contre le Cancer T4 and M1 were both significantly higher in younger patients, resulting in a higher percentage of patients with Union Internationale Contre le Cancer stage IV. Pancreatectomy was performed less frequently in the younger group, and R0 resection was also less frequent. The overall survival rate was significantly better in the older group, whereas in surgically resected patients, the overall survival and recurrence-free survival rates were not different between the 2 groups. CONCLUSIONS: Younger patients with pancreatic adenocarcinoma were more often diagnosed at advanced stages, and the overall survival rate was worse than that in older patients. Family genetic background and the prognoses of patients who underwent surgery were similar between the 2 groups.

  1485. Comparison of laparoscopic major hepatectomy with propensity score matched open cases from the National Clinical Database in Japan Peer-reviewed

    Takahara Takeshi, Wakabayashi Go, Konno Hiroyuki, Gotoh Mitsukazu, Yamaue Hiroki, Yanaga Katsuhiko, Fujimoto Jirou, Kaneko Hironori, Unno Michiaki, Endo Itaru, Seto Yasuyuki, Miyata Hiroaki, Miyazaki Masaru, Yamamoto Masakazu

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　23　(11)　721-734　2016/11

    DOI： 10.1002/jhbp.405 　

    ISSN： 1868-6974

  1486. 肝動脈走行破格と術前治療により腹腔動脈合併膵頭十二指腸切除で切除し得た膵癌の1例

    客本 ゆき恵, 水間 正道, 阿部 友哉, 高舘 達之, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 元井 冬彦, 菅野 敦, 下瀬川 徹, 海野 倫明

    癌と化学療法　43　(12)　1966-1968　2016/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1487. [A Case of Successful Stomach-Preserving Pancreaticoduodenectomy with Celiac Artery Resection after Neoadjuvant Chemoradiation Therapy for Pancreatic Cancer with Hepatic Arterial Variation]. Peer-reviewed

    Kyakumoto Y, Mizuma M, Abe T, Takadate T, Fukase K, Otsuka H, Sakata N, Nakagawa K, Morikawa T, Hayashi H, Naitoh T, Motoi F, Kanno A, Shimosegawa T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　43　(12)　1966-1968　2016/11

    ISSN： 0385-0684

  1488. Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. International-journal Peer-reviewed

    Murakami K, Nakamura Y, Felizola SJ, Morimoto R, Satoh F, Takanami K, Katakami H, Hirota S, Takeda Y, Meguro-Horike M, Horike S, Unno M, Sasano H

    Molecular and cellular endocrinology　436　268-273　2016/11

    DOI： 10.1016/j.mce.2016.08.044 　

    ISSN： 0303-7207

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    Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II. We report the first case of pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. An 82-year-old Japanese man presented with lower limb edema, uncontrolled hypertension, hypokalemia, and baseline hypercortisolism. Distal pancreatectomy was performed after the clinical diagnosis of a neuroendocrine tumor with ectopic secretion of adrenocorticotropic hormone. On histological examination, the tumor showed spindle cells in a fascicular arrangement. The diagnosis of the solitary fibrous tumor was confirmed by the identification of the NAB2-STAT6 fusion gene and positive immuno-histochemical staining for STAT6 and CD34. Using quantitative real-time polymerase chain reaction, mRNA that encoded proopiomelanocortin, precursor of adrenocorticotropic hormone, was detected. Proopiomelanocortin production through the demethylation of the promoter region Domain IV was detected. Pancreatic solitary fibrous tumors represent a new cause of ectopic adrenocorticotropic hormone syndrome.

  1489. [A Successful Case of Conversion Therapy after Chemotherapy for Advanced Rectal Cancer with Inguinal Lymph Node Metastasis]. Peer-reviewed

    Sato J, Karasawa H, Maeda S, Ohnuma S, Watanabe K, Nagao M, Abe T, Musha H, Motoi F, Naitoh T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　43　(12)　2145-2147　2016/11

    ISSN： 0385-0684

  1490. [Resection of a Huge Gastrointestinal Stromal Tumor of the Stomach Following Neoadjuvant Chemotherapy with Imatinib]. Peer-reviewed

    Sato Y, Karasawa H, Aoki T, Imoto H, Tanaka N, Watanabe K, Abe T, Nagao M, Ohnuma S, Musha H, Takahashi M, Motoi F, Naitoh T, Ishioka C, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　43　(12)　2216-2218　2016/11

    ISSN： 0385-0684

  1491. [A Case of Undifferentiated Carcinoma of the Sigmoid Colon That Responded to Paclitaxel and Carboplatin Chemotherapy]. Peer-reviewed

    Toyama S, Kudoh K, Ohnuma S, Sato S, Tanaka N, Aoki T, Imoto H, Karasawa H, Watanabe K, Nagao M, Abe T, Musha H, Motoi F, Naitoh T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　43　(12)　2295-2297　2016/11

    ISSN： 0385-0684

  1492. Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties. International-journal Peer-reviewed

    Aoki S, Mizuma M, Takahashi Y, Haji Y, Okada R, Abe T, Karasawa H, Tamai K, Okada T, Morikawa T, Hayashi H, Nakagawa K, Motoi F, Naitoh T, Katayose Y, Unno M

    BMC cancer　16　(1)　854-854　2016/11

    DOI： 10.1186/s12885-016-2919-4 　

    eISSN： 1471-2407

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    BACKGROUND: Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression of hairy and enhancer of split 1 (Hes-1) has not been investigated yet in resected specimens of CC. Notch signaling has been reported to be related to cancer stem cell (CSC) like properties in some malignancies. Our aim is to investigate the participation of Notch signaling in resected specimens of extrahepatic CC (EHCC) and to evaluate the efficacy of CC cells with CSC-like properties by Notch signaling blockade. METHODS: First, the expression of Notch1, 2, 3, 4 and Hes-1 was examined by immunohistochemistry in 132 resected EHCC specimens. The clinicopathological characteristics in the expression of Notch receptors and Hes-1 were investigated. Second, GSI IX, which is a γ-secretase-inhibitor, was used for Notch signaling blockade in the following experiment. Alterations of the subpopulation of CD24+CD44+ cells, which are surface markers of CSCs in EHCC, after exposure with GSI IX, gemcitabine (GEM), and the combination of GSI IX plus GEM were assessed by flow cytometry using the human CC cell lines, RBE, HuCCT1 and TFK-1. Also, anchorage-independent growth and mice tumorigenicity in the cells recovered by regular culture media after GSI IX exposure were assessed. RESULTS: Notch1, 2, 3, 4 and Hes-1 in the resected EHCC specimens were expressed in 50.0, 56.1, 42.4, 6.1, and 81.8 % of the total cohort, respectively. Notch1 and 3 expressions were associated with poorer histological differentiation (P = 0.008 and 0.053). The patients with the expression of at least any one of Notch1-3 receptors, who were in 80.3 % of the total, exhibited poorer survival (P = 0.050). Similarly, the expression of Hes-1 tended to show poor survival (P = 0.093). In all of the examined CC cell lines, GSI IX treatment significantly diminished the subpopulation of CD24+CD44+ cells. Although GEM monotherapy relatively increased the subpopulation of CD24+CD44+ cells in all lines, GSI IX plus GEM attenuated it. Anchorage-independent growth and mice tumorigenicity were inhibited in GSI IX-pretreated cells in RBE and TFK-1 (P < 0.05). CONCLUSION: Aberrant Notch signaling is involved with EHCC. Inhibition of Notch signaling is a novel therapeutic strategy for targeting cells with CSC-like properties.

  1493. 大腸癌で発現が抑制されるPeptidylarginine deiminase 2の機能解析 Peer-reviewed

    谷口 肇, 舟山 亮, 小林 実, 高館 達之, 阿部 友哉, 水間 正道, 藤島 史喜, 大沼 忍, 内藤 剛, 海野 倫明, 中山 啓子

    日本癌学会総会記事　75回　P-1267　2016/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1494. 膵体尾部切除における膵断端処理の工夫 尾側膵切除術における膵断端処理法の多施設共同ランダム化比較試験 断端膵管胃粘膜吻合vs.膵断端縫合閉鎖 Peer-reviewed

    上村 健一郎, 里井 壮平, 元井 冬彦, 橋本 泰司, 柳本 泰明, 深瀬 耕二, 權 雅憲, 海野 倫明, 村上 義昭

    日本臨床外科学会雑誌　77　(増刊)　405-405　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1495. 膵臓 耐容性の低い患者に対する包括的がん治療 多施設共同研究による高齢者膵癌に対する切除意義および予後因子の解析 Peer-reviewed

    庄 雅之, 村上 義昭, 川井 学, 元井 冬彦, 里井 壮平, 松本 逸平, 本田 五郎, 上村 健一郎, 柳本 泰明, 赤堀 宇広, 木下 正一, 長井 美奈子, 西和田 敏, 海野 倫明, 山上 裕機

    日本癌治療学会学術集会抄録集　54回　WS5-1　2016/10

    Publisher: (一社)日本癌治療学会

  1496. 胆道癌に対するCT、MRI、PETの役割 特にPETの活用法について

    片寄 友, 中川 圭, 深瀬 耕二, 元井 冬彦, 徳村 弘実, 海野 倫明

    胆道　30　(4)　659-666　2016/10

    Publisher: 日本胆道学会

    DOI： 10.11210/tando.30.659 　

    ISSN： 0914-0077

  1497. 先天性胆道拡張症に伴う胆管癌術後に発症した肝門部領域遺残胆管癌の1例

    佐藤 正規, 有明 恭平, 大塚 英郎, 深瀬 耕二, 中川 圭, 青木 豪, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　30　(4)　749-755　2016/10

    Publisher: 日本胆道学会

    DOI： 10.11210/tando.30.749 　

    ISSN： 0914-0077

  1498. 消化器疾患と代謝異常の関わり 膵癌術前治療における骨格筋量の変化と予後に関する検討

    志村 充広, 水間 正道, 海野 倫明

    日本消化器病学会雑誌　113　(臨増大会)　A566-A566　2016/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1499. Muse細胞投与はマウス急性膵炎モデルを改善する

    深瀬 正彦, 坂田 直昭, 串田 良祐, 若尾 昌平, 海野 倫明, 出澤 真理

    移植　51　(総会臨時)　320-320　2016/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  1500. Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model Peer-reviewed

    Kei Kawaguchi, Takashi Murakami, Bartosz Chmielowski, Kentaro Igarashi, Tasuku Kiyuna, Michiaki Unno, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Fritz C. Eilber, Robert M. Hoffman

    Oncotarget　7　(44)　2016/09

    Publisher: Impact Journals, {LLC}

    DOI： 10.18632/oncotarget.12328 　

    ISSN： 1949-2553

  1501. Outcomes after resection of occupational cholangiocarcinoma Peer-reviewed

    Kubo Shoji, Takemura Shigekazu, Tanaka Shogo, Shinkawa Hiroji, Kinoshita Masahiko, Hamano Genya, Ito Tokuji, Koda Masaki, Aota Takanori, Yamamoto Takatsugu, Terajima Hiroaki, Tachiyama Gorou, Yamada Terumasa, Nakamori Shoji, Arimoto Akira, Fujikawa Masahiro, Tomimaru Yoshito, Sugawara Yasuhiko, Nakagawa Kei, Unno Michiaki, Mizuguchi Toru, Takenaka Kenji, Kimura Koichi, Shirabe Ken, Saiura Akio, Uesaka Katsuhiko, Taniguchi Hiroki, Fukuda Akira, Chong Ja-Mun, Kuwae Yuko, Ohsawa Masahiko, Sato Yasunori, Nakanuma Yasuni

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　23　(9)　556-564　2016/09

    DOI： 10.1002/jhbp.373 　

    ISSN： 1868-6974

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    BACKGROUND: Cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane is recognized as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease. METHODS: Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated. RESULTS: Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients. CONCLUSIONS: The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.

  1502. 経皮的心肺補助法で救命した緊急手術時たこつぼ心筋症による心停止の1例 Peer-reviewed

    佐藤 英昭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(9)　2175-2179　2016/09

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.77.2175 　

    ISSN： 1345-2843

  1503. Reappraisal of Total Pancreatectomy in 45 Patients With Pancreatic Ductal Adenocarcinoma in the Modern Era Using Matched-Pairs Analysis: Multicenter Study Group of Pancreatobiliary Surgery in Japan. International-journal Peer-reviewed

    Satoi S, Murakami Y, Motoi F, Sho M, Matsumoto I, Uemura K, Kawai M, Kurata M, Yanagimoto H, Yamamoto T, Mizuma M, Unno M, Kinoshita S, Akahori T, Shinzeki M, Fukumoto T, Hashimoto Y, Hirono S, Yamaue H, Honda G, Kwon M

    Pancreas　45　(7)　1003-1009　2016/08

    DOI： 10.1097/MPA.0000000000000579 　

    ISSN： 0885-3177

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    OBJECTIVE: The aim of this study was to reappraise the clinical role of total pancreatectomy with curative intent in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: In 2001 to 2011 database from 7 institutions in Japan, 45 (3.1%) of 1451 patients with PDAC underwent total pancreatectomy (TP group), and 885 patients underwent pancreaticoduodenectomy (PD group). A matched-pairs group consisted of 45 patients matched for age, sex, year, resectability status, and neoadjuvant therapy (matched-PD group). Clinicopathological data, overall survival, and disease-free survival were compared between groups. RESULTS: Clinical features of the TP group revealed higher-stage disease, greater surgical stress, a higher frequency of lymph node metastasis, and a lower adjuvant chemotherapy completion rate compared with the PD group (P < 0.05). Overall survival and disease-free survival in the TP group were significantly worse than those in the PD group (P < 0.05). Multivariate analysis revealed resectability status, neoadjuvant therapy, blood transfusion, lymph node metastasis, and adjuvant therapy to be significant prognostic factors. No differences in mortality and morbidity rates were observed between the 2 groups. A matched-pairs analysis revealed similar surgical outcomes and overall survival. CONCLUSIONS: The surgical outcome of total pancreatectomy for patients with PDAC is acceptable. When margin-negative resection is expected, total pancreatectomy should not be abandoned in the modern era.

  1504. Grade B pancreatic fistulas do not affect survival after pancreatectomy for pancreatic cancer: A multicenter observational study. International-journal Peer-reviewed

    Kawai M, Murakami Y, Motoi F, Sho M, Satoi S, Matsumoto I, Honda G, Hirono S, Okada K, Unno M, Nakajima Y, Uemura K, Kwon AH, Fukumoto T, Kurata M, Yamaue H

    Surgery　160　(2)　293-305　2016/08

    DOI： 10.1016/j.surg.2016.02.032 　

    ISSN： 0039-6060

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    BACKGROUND: Several studies have demonstrated that postoperative complications after pancreatectomy for pancreatic cancer adversely affect survival. The impact on survival of a pancreatic fistula according to the classification of the International Study Group for Pancreatic Surgery has not been fully evaluated. The aim of this multicenter, observational study was to evaluate the impact of pancreatic fistula on pancreatic cancer patients who had undergone pancreatectomy. METHODS: Between 2001 and 2012, 1,397 patients who underwent pancreatectomy for pancreatic cancer at 7 high-volume centers in Japan were reviewed retrospectively. The impact of pancreatic fistula on survival was evaluated by univariate and multivariate analysis. RESULTS: Pancreatic fistula occurred in 327 of 1,397 patients (23.4%) and was classified based on the International Study Group for Pancreatic Surgery as follows: grade A in 9.9%, grade B in 10.6%, and grade C in 2.9% of the patients. Median survival time in no fistula/grade A, grade B, and grade C were 23.6, 26.0, and 9.0 months, respectively. There was no significant difference in overall survival between patients with no fistula/grade A and those with grade B (P = .403); in contrast, overall survival in patients with grade C was worse than in patients without grade C (P < .001). The multivariate Cox proportional hazard analysis demonstrated that grade C pancreatic fistula was an independent prognostic factor (hazard ratio 1.59; 95% confidence interval, 1.03-2.45; P = .035). CONCLUSION: Grade B pancreatic fistula after pancreatectomy does not adversely affect long-term survival, but a grade C pancreatic fistula has a negative impact on long-term survival of patients with pancreatic cancer.

  1505. 外科における基礎的研究 セレンディピティーを求めて 膵癌細胞におけるWnt関連蛋白LRRFIP1による上皮間葉転換の制御と、浸潤転移機構の解析

    大塚 英郎, 堂地 大輔, 有明 恭平, 川崎 修平, 深瀬 耕二, 益田 邦洋, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　WS7-8　2016/07

    Publisher: (一社)日本消化器外科学会

  1506. 主膵管の管内乳頭粘液性腫瘍を合併した自己免疫性膵炎の一例(A case of autoimmune pancreatitis concomitant with a main duct intraductal papillary mucinous neoplasm)

    Nakano Eriko, Kanno Atsushi, Masamune Atsushi, Yoshida Naoki, Hongo Seiji, Miura Shin, Hamada Shin, Kume Kiyoshi, Kikuta Kazuhiro, Hirota Morihisa, Morikawa Takanori, Fukase Koji, Unno Michiaki, Fujishima Fumiyoshi, Shimosegawa Tooru

    膵臓　31　(3)　557-558　2016/07

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1507. Strategy of Symptom-Targeted Intervention Based on Patient Quality of Life at Three Months After Pancreatectomy Peer-reviewed

    Sato Naoko, Katayose Yu, Motoi Fuyuhiko, Nakagawa Kei, Sakata Naoaki, Kawaguchi Kei, Sato Fumiko, Unno Michiaki

    PANCREAS　45　(6)　920-921　2016/07

    ISSN： 0885-3177

  1508. Borderline resectable膵癌と術前化学放射線療法 Invited

    中川 圭, 元井 冬彦, 水間 正道, 中村 聡明, 片寄 友, 神宮 啓一, 海野 倫明

    コンセンサス癌治療　14　(2)　107-110　2016/07

  1509. 【膵・胆道癌の治療戦略:こんなときどうするか?-ガイドラインにないエキスパートオピニオン-】 肝内胆管癌で腹腔内リンパ節はどこまで切除するか?

    益田 邦洋, 中川 圭, 深瀬 耕二, 元井 冬彦, 海野 倫明

    胆と膵　37　(6)　505-510　2016/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1510. 高齢者膵癌における膵切除の意義に関する多施設共同研究(Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study) Peer-reviewed

    西和田 敏, 庄 雅之, 村上 義昭, 川井 学, 元井 冬彦, 里井 壯平, 上村 健一郎, 柳本 泰明, 赤堀 宇広, 木下 正一, 長井 美奈子, 海野 倫明, 山上 裕機, 中島 祥介

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　391-391　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  1511. Validation of the board certification system for expert surgeons (hepato-biliary-pancreatic field) using the data of the National Clinical Database of Japan: part 1 - Hepatectomy of more than one segment. Peer-reviewed

    Miura F, Yamamoto M, Gotoh M, Konno H, Fujimoto J, Yanaga K, Kokudo N, Yamaue H, Wakabayashi G, Seto Y, Unno M, Miyata H, Hirahara N, Miyazaki M

    Journal of hepato-biliary-pancreatic sciences　23　(6)　313-323　2016/06

    DOI： 10.1002/jhbp.344 　

    ISSN： 1868-6974

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    BACKGROUND: The objective of this study was to validate the board certification system of the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) using the data of hepatectomy cases from the National Clinical Database (NCD) of Japan. METHODS: Minimal required annual numbers of high-level hepato-biliary-pancreatic (HBP) surgeries were 50 for a board-certified A training institution and 30 for a board-certified B training institution. Records of 14,970 patients who had undergone hepatectomy of more than one segment (MOS), excluding lateral segmentectomy, during 2011 and 2012 were analyzed according to the category of board-certified institution and with or without participation of board-certified instructors or expert surgeons. RESULTS: Thirty-day mortality and operative mortality of 14,970 patients after MOS hepatectomy were 1.9% and 3.8%, respectively. Operative mortality rates after MOS hepatectomies performed at certified A institutions, certified B institutions, and non-certified institutions were 3.1%, 3.8%, and 4.5%, respectively (P < 0.001). The operative mortality rates after MOS hepatectomies performed with participation of certified instructors or expert surgeons were better than those without (3.5% vs. 4.3%, P = 0.012). A multiple logistic regression model showed that the cutoffs of high-level HBP surgeries performed per year at hospitals that predicted operative mortality after MOS hepatectomies were 10 and 50. CONCLUSIONS: Competences and requirements for board-certified institutions, instructors, and expert surgeons to perform hepatectomy were found to be appropriate.

  1512. Validation of the board certification system for expert surgeons (hepato-biliary-pancreatic field) using the data of the National Clinical Database of Japan: part 2 - Pancreatoduodenectomy. Peer-reviewed

    Miura F, Yamamoto M, Gotoh M, Konno H, Fujimoto J, Yanaga K, Kokudo N, Yamaue H, Wakabayashi G, Seto Y, Unno M, Miyata H, Hirahara N, Miyazaki M

    Journal of hepato-biliary-pancreatic sciences　23　(6)　353-363　2016/06

    DOI： 10.1002/jhbp.348 　

    ISSN： 1868-6974

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    BACKGROUND: Data of pancreatoduodenectomy (PD) cases from the National Clinical Database (NCD) were analyzed in order to validate the board certification system established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS). METHODS: Board-certified A training institutions and board-certified B training institutions were required to perform at least 50 and 30 high-level hepato-biliary-pancreatic (HBP) surgeries per year, respectively. Records of 17,563 patients who had undergone PD during 2011 and 2012 were retrospectively analyzed according to the category of the board-certified institution and with or without participation of board-certified instructors or expert surgeons. RESULTS: Operative mortality rates after PDs performed at certified A institutions, certified B institutions, and non-certified institutions were 1.5%, 3.0%, and 3.9%, respectively (P < 0.001). The operative mortality rates after PDs performed with participation of certified instructors or expert surgeons were better than those without (2.2% vs. 3.8%, P < 0.001). A multiple logistic regression model showed that cutoffs of high-level HBP surgeries performed per year at hospitals that predicted 30-day mortality after PDs were 10 and 50, and that those that predicted operative mortality were 10 and 70. CONCLUSIONS: The requirements for board-certified institutions, instructors, and expert surgeons to perform PD were appropriate. The requirements for board-certified A institutions were close to the identified cutoffs. Further analyses are necessary to elucidate the implications of the board certification system.

  1513. Risk factors for recurrent biliary obstruction following placement of self-expandable metallic stents in patients with malignant perihilar biliary stricture. International-journal Peer-reviewed

    Miura S, Kanno A, Masamune A, Hamada S, Hongou S, Yoshida N, Nakano E, Takikawa T, Kume K, Kikuta K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T

    Endoscopy　48　(6)　536-545　2016/06

    DOI： 10.1055/s-0042-102651 　

    ISSN： 0013-726X

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    BACKGROUND AND STUDY AIM: Self-expandable metallic stents (SEMSs) are used for palliation in patients with malignant perihilar biliary strictures. However, recurrent biliary obstruction occasionally causes cholangitis and jaundice. This study aimed to identify risk factors for recurrent biliary obstruction in such patients. METHODS: Data from consecutive patients with malignant perihilar biliary strictures treated with endoscopic placement of SEMSs between 2007 and 2014 in Tohoku University Hospital were retrospectively reviewed. Risk factors for recurrent biliary obstruction were calculated using the Cox proportional hazards models (with hazard ratios [HRs] and 95 % confidence interval [95 %CIs]), and SEMS patency period was examined using the Kaplan - Meier method. SEMS patency was defined as the period between SEMS insertion and the development of recurrent biliary obstruction. RESULTS: 104 patients were included. Median survival time was 281 days; and 85 patients died during a median follow-up period of 320 days. Recurrent biliary obstruction occurred in 35 patients. Median SEMS patency period was 549 days. Multivariable analyses showed that: compared with bile duct carcinoma, gallbladder carcinoma was associated with shorter SEMS patency (HR 8.18, 95 %CI 2.41 - 26.83); patency of left-sided SEMS was inferior to that of bilateral (HR 0.5, 95 %CI 0.32 - 0.93) and right-sided SEMS (HR 0.1, 95 %CI 0.02 - 0.65). Cholangitis before SEMS placement increased the risk of recurrent biliary obstruction (HR 11.44; 95 %CI 4.48 - 32.35) and reduced the SEMS patency period (746 vs. 210 days). CONCLUSION: Gallbladder carcinoma, left-sided stent placement, and cholangitis before SEMS placement are risk factors for recurrent biliary obstruction after SEMS placement.

  1514. 【診療ガイドライン改訂後の膵炎診療】 慢性膵炎 慢性膵炎に対するFrey手術． Invited

    元井冬彦, 石田晶玄, 坂田直昭, 江川新一, 内藤 剛, 下瀬川徹, 海野倫明

    肝胆膵　72　(6)　1105-1110　2016/06

    ISSN： 0389-4991

  1515. 【膵切除・膵再建を再考する】膵再建 縫合糸ホルダーASRCを用いて定型化した膵管空腸粘膜吻合 Peer-reviewed

    中川 圭, 元井 冬彦, 海野 倫明

    手術　70　(7)　919-924　2016/06

    Publisher: 金原出版(株)

    DOI： 10.18888/J00620.2016287830 　

    ISSN： 0037-4423

  1516. Surgical anatomy of the right hepatic artery in Rouviere's sulcus evaluated by preoperative multidetector-row CT images. International-journal Peer-reviewed

    Aoki S, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Naitoh T, Egawa S, Unno M

    BMC surgery　16　(1)　40-40　2016/06

    DOI： 10.1186/s12893-016-0155-0 　

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    BACKGROUND: Lymph node dissection in Rouviere's sulcus (RS) is essential during left-sided hepatectomy and caudate lobectomy for hilar cholangiocarcinoma. However, the small segmental or subsegmental arteries (SA/SSA) are often encountered in RS and must be preserved to prevent critical complications, such as liver infarction or liver failure. The aim of this study is to elucidate the anatomy of SA/SSA around RS, which should be understood preoperatively. METHODS: Between January 2008 and April 2013 from a total of 124 consecutive patients with hilar cholangiocarcinoma, preoperative multidetector-row computed tomography (MDCT) images were obtained at our institution and evaluated. The bifurcation patterns of the SA/SSA, the courses of the posterior SA/SSA and the bifurcation site of the SA/SSA were investigated using MDCT images. RESULTS: The typical form, in which right hepatic artery (RHA) bifurcated into the anterior (Aant) and posterior (Apost) hepatic artery and thereafter, Aant/Apost bifurcated into the SA and SSA, was observed in 75 patients (60.5 %). On the other hand, the atypical forms, in which the SA/SSA were independently branched off from RHA before the main bifurcation of the Aant and Apost, were observed in 43 patients (34.7 %). The prior branched arteries supplied the whole or ventral area of segment VI (A6 or A6a) in 11 patients (8.9 %), which was most commonly observed in the atypical form. 15 patients (34.9 %) of the 43 patients with atypical form had partially supraportal posterior branches, that showed early-bifurcated posterior SA/SAA following supraportal course, while the other posterior SA/SSA followed infraportal course. The SA/SSA were extrahepatically bifurcated in 82 patients (66.1 %), comprised of all 43 atypical form and 39 of typical form, while the SA/SSA were intrahepatically bifurcated in remaining 36 patients of typical forms (29.0 %). CONCLUSION: The extrahepatic bifurcation of the SA/SSA from RHA was relatively common. The early-bifurcated SA/SSA was often observed (34.7 % of total cohort) and, in 34.8 % of those atypical forms, posterior SA/SSA from RHA followed a supraportal course. The detailed preoperative knowledge of the anatomy, including SA/SSA, is crucial for left-sided hepatectomy for hilar cholangiocarcinoma.

  1517. Indocyanine green蛍光法が胆管損傷の予防に有用であった肝嚢胞の1例

    井上 亨悦, 森川 孝則, 赤田 昌紀, 上野 達也, 海野 倫明, 内藤 広郎

    日本臨床外科学会雑誌　77　(5)　1202-1206　2016/05

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.77.1202 　

    ISSN： 1345-2843

  1518. Biliopancreatic limb plays an important role in metabolic improvement after duodenal-jejunal bypass in a rat model of diabetes. International-journal Peer-reviewed

    Miyachi T, Nagao M, Shibata C, Kitahara Y, Tanaka N, Watanabe K, Tsuchiya T, Motoi F, Naitoh T, Unno M

    Surgery　159　(5)　1360-1371　2016/05

    DOI： 10.1016/j.surg.2015.11.027 　

    ISSN： 0039-6060

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    BACKGROUND AND AIMS: Roux-en-Y gastric bypass improves glucose metabolism in clinical practice, and duodenal-jejunal bypass (DJB), an experimental bypass procedure, also improves metabolism in animals. However, the mechanism remains controversial; especially, the role of the biliopancreatic limb (BP-limb) remains unclear. Our aim was to examine the importance of the function of the BP-limb after DJB using a novel operative model. METHODS: Otsuka Long-Evans Tokushima Fatty rats with diabetes were divided into the following groups: DJB with a short alimentary limb (A-limb) and long BP-limb (B-DJB group), DJB with jejunectomy (J-DJB group) in which the entire length of the jejunum used for the BP-limb of the B-DJB group was excised; and a sham operation group. Glucose tolerance, plasma bile acid levels, and the gut microbiota were assessed postoperatively. RESULTS: Glucose tolerance was improved and weight gain was suppressed after surgery in the B-DJB group. In contrast, these effects were cancelled in the J-DJB group. The plasma levels of bile acids in the B-DJB group were greater than those in other groups. The analysis of gut microbiota showed distinct differences between the B-DJB and other groups; especially, the relative abundance of genus Bifidobacterium was much higher in the B-DJB group. CONCLUSION: The BP-limb played an important role in the control of weight gain, glucose tolerance, and increased plasma bile acid levels after DJB in this rat model of type 2 diabetes mellitus. Plasma bile acids and gut microbiota may be involved in these processes.

  1519. Telomerase activity in pancreatic juice differentiates pancreatic cancer from chronic pancreatitis: A meta-analysis. Peer-reviewed

    Hata T, Ishida M, Motoi F, Yamaguchi T, Naitoh T, Katayose Y, Egawa S, Unno M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　16　(3)　372-381　2016/05

    DOI： 10.1016/j.pan.2016.01.007 　

    ISSN： 1424-3903

  1520. SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer. International-journal Peer-reviewed

    Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M

    Cancer science　107　(5)　619-628　2016/05

    DOI： 10.1111/cas.12909 　

    ISSN： 1347-9032

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    An increasingly accepted concept is that the progression of colorectal cancer is accompanied by epithelial-mesenchymal transition (EMT). In our study, in order to characterize the properties of EMT in 16 colorectal cancer cell lines, the cells were first orthotopically implanted into nude mice, and the tumors in vivo, as well as cells cultured in vitro, were immunostained for EMT markers. The immunostaining revealed that seven of the cells had an epithelial phenotype with a high expression of E-cadherin, whereas other cells showed opposite patterns, such as a high expression of vimentin (CX-1, COLO205, CloneA, HCT116, and SW48). Among the cells expressing vimentin, some expressed vimentin in the orthotopic tumors but not in the cultured cells (SW480, SW620, and COLO320). We evaluated these findings in combination with microarray analyses, and selected five genes: CHST11, SERPINI1, AGR2, FBP1, and FOXA1. Next, we downregulated the expression of SERPINI1 with siRNA in the cells, the results of which showed reverse-EMT changes at the protein level and in the cellular morphology. Along with immunohistochemical analyses, we confirmed the effect of the intracellular and secreted SERPINI1 protein of SW620 cells, which supported the importance of SERPINI1 in EMT. The development of therapeutic strategies targeting EMT is ongoing, including methods targeting the transforming growth factor-β signaling pathway as well as the Wnt pathway. SERPINI1 is an important regulator of EMT. Our findings help to elucidate the signaling pathways of EMT, hopefully clarifying therapeutic pathways as well.

  1521. Immunohistochemical analysis of steroidogenic enzymes in ovarian-type stroma of pancreatic mucinous cystic neoplasms: Comparative study of subepithelial stromal cells in intraductal papillary mucinous neoplasms of the pancreas. Peer-reviewed

    Ishida K, Sasano H, Moriya T, Takahashi Y, Sugimoto R, Mue Y, Murakami K, Fujishima F, Nakamura Y, Morikawa T, Motoi F, Suzuki T, Unno M, Sugai T

    Pathology international　66　(5)　281-287　2016/05

    DOI： 10.1111/pin.12406 　

    ISSN： 1320-5463

    eISSN： 1440-1827

  1522. 80歳以上高齢者膵癌に対する外科治療成績 多施設共同研究 Peer-reviewed

    庄 雅之, 村上 義昭, 川井 学, 元井 冬彦, 里井 壮平, 松本 逸平, 本田 五郎, 上村 健一郎, 柳本 泰明, 倉田 昌直, 赤堀 宇広, 木下 正一, 長井 美奈子, 西和田 敏, 海野 倫明, 山上 裕機, 中島 祥介

    日本外科学会定期学術集会抄録集　116回　OP-6　2016/04

    Publisher: (一社)日本外科学会

  1523. Phase II Study of Intravenous and Intraperitoneal Paclitaxel With S-1 for Pancreatic Ductal Adenocarcinoma Patients With Peritoneal Metastasis Peer-reviewed

    Mizuma Masamichi, Satoi Sohei, Fujii Tsutomu, Yanagimoto Hiroaki, Kurata Masanao, Takahara Naminatsu, Yamada Suguru, Motoi Fuyuhiko, Yamamoto Tomohisa, Honda Goro, Isayama Hiroyuki, Ishigami Hironori, Unno Michiaki, Kwon A-Hon

    GASTROENTEROLOGY　150　(4)　S319　2016/04

    DOI： 10.1016/S0016-5085(16)31119-2 　

    ISSN： 0016-5085

  1524. Effect of Hospital Volume on Surgical Outcomes After Pancreaticoduodenectomy: A Systematic Review and Meta-analysis. Peer-reviewed

    Hata T, Motoi F, Ishida M, Naitoh T, Katayose Y, Egawa S, Unno M

    Annals of surgery　263　(4)　664-672　2016/04

    DOI： 10.1097/SLA.0000000000001437 　

    ISSN： 0003-4932

  1525. A case of a ruptured submucosal aneurysm of the small intestine identified using double-balloon enteroscopy. Peer-reviewed

    Chiba H, Endo K, Fujishima F, Ohtsuka H, Naitoh T, Kuroha M, Kimura T, Shiga H, Kakuta Y, Kinouchi Y, Unno M, Shimosegawa T

    Clinical journal of gastroenterology　9　(2)　49-54　2016/04

    DOI： 10.1007/s12328-016-0639-6 　

    ISSN： 1865-7257

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    A 47-year-old woman was admitted to our hospital urgently with sudden-onset hematochezia. She was temporarily in a state of hemorrhagic shock. As we strongly suspected bleeding from the small intestine, peroral double-balloon enteroscopy was performed, and indicated a 2.0-cm diameter hemispheric elevated lesion in the jejunum. Moreover, a blood clot was observed at the top of the protrusion. The site was marked by injecting India ink, without taking a biopsy specimen, to avoid further hemorrhaging. Subsequently, laparoscopic partial small bowel resection was performed. On histopathological examination, the lesion was found to be a sac-like submucosal arterial aneurysm, with a diameter of 3.5 mm, comprising several small abnormal arteries. The final diagnosis was a ruptured submucosal aneurysm of the small intestine. Ruptured submucosal aneurysms are very rarely observed in the small intestine. Only a few reports have described their endoscopic findings. Our experience indicates that small bowel enteroscopy may be useful for managing ruptured submucosal aneurysms of the small intestine.

  1526. Does Tacrolimus Affect the Outcome After Surgery for Ulcerative Colitis? Peer-reviewed

    Nagao Munenori, Watanabe Kazuhiro, Karasawa Hideaki, Abe Tomoya, Ohnuma Shinobu, Musha Hiroaki, Shibata Chikashi, Naitoh Takeshi, Unno Michiaki

    GASTROENTEROLOGY　150　(4)　S1218-S1219　2016/04

    DOI： 10.1016/S0016-5085(16)34123-3 　

    ISSN： 0016-5085

  1527. Clinical Characteristics and Risk Factors for the Development of Postoperative Hepatic Steatosis After Total Pancreatectomy. Peer-reviewed

    Hata T, Ishida M, Motoi F, Sakata N, Yoshimatsu G, Naitoh T, Katayose Y, Egawa S, Unno M

    Pancreas　45　(3)　362-369　2016/03

    DOI： 10.1097/MPA.0000000000000462 　

    ISSN： 0885-3177

  1528. Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study. Peer-reviewed

    Sho M, Murakami Y, Kawai M, Motoi F, Satoi S, Matsumoto I, Honda G, Uemura K, Yanagimoto H, Kurata M, Akahori T, Kinoshita S, Nagai M, Nishiwada S, Fukumoto T, Unno M, Yamaue H, Nakajima Y

    Journal of hepato-biliary-pancreatic sciences　23　(3)　188-197　2016/03

    DOI： 10.1002/jhbp.320 　

    ISSN： 1868-6974

  1529. 膵外分泌機能不全と膵酵素補充療法の進歩 慢性膵炎のFrey術後の栄養状態の変化

    江川新一, 佐々木宏之, 高舘達之, 有明恭平, 前田晋平, 益田邦洋, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 元井冬彦, 内藤剛, 海野倫明, 江川新一, 佐々木宏之, 高舘達之, 有明恭平, 前田晋平, 益田邦洋, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 元井冬彦, 内藤剛, 海野倫明

    胆とすい　37　(2)　185‐189　2016/02/15

    ISSN： 0388-9408

  1530. Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma Peer-reviewed

    Kinoshita Masahiko, Kubo Shoji, Nakanuma Yasuni, Sato Yasunori, Takemura Shigekazu, Tanaka Shogo, Hamano Genya, Ito Tokuji, Terajima Hiroaki, Yamada Terumasa, Nakamori Shoji, Arimoto Akira, Fujikawa Masahiro, Sugawara Yasuhiko, Yamamoto Takatsugu, Abue Makoto, Nakagawa Kei, Unno Michiaki, Mizuguchi Toru, Takenaka Kenji, Shirabe Ken, Shibata Toshihiko

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　23　(2)　92-101　2016/02

    DOI： 10.1002/jhbp.305 　

    ISSN： 1868-6974

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    BACKGROUND: We aimed to identify the pathological characteristics of occupational cholangiocarcinoma. METHODS: We examined the location and distribution of the carcinomas: atypical epithelium including biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB); and chronic bile duct injuries in operative or autopsy liver specimens from 16 patients. We examined the detailed pathological findings and diagnostic imaging of three patients. Immunohistochemical analysis using primary antibodies against γH2AX and S100P was performed. RESULTS: BilIN and chronic bile duct injury were observed in 16 patients, and IPNB or invasive IPNB was observed in 11 patients. BilIN, IPNB, and/or chronic bile duct injury were observed in almost all the large bile ducts. Regional dilatation of the bile ducts without tumor-induced obstruction revealed such pathological changes. Highly positive results for the γH2AX and S100P markers were noted in invasive carcinoma, BilIN, and IPNB, whereas positive results for γH2AX and negative results for S100P were noted in non-neoplastic biliary epithelium. CONCLUSIONS: The carcinogenic process of occupational cholangiocarcinoma comprised chronic bile duct injury and DNA damage in almost all the large bile ducts, along with induction of precancerous lesions and development of invasive carcinoma. Such pathological findings reflected radiological changes on diagnostic imaging.

  1531. 慢性膵炎のFrey術後の栄養状態の変化 Invited

    江川新一, 佐々木宏之, 高舘達之, 有明恭平, 前田晋平, 益田邦洋, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林 洋毅, 中川 圭, 元井冬彦, 内藤 剛, 海野倫明

    胆と膵　37　(2)　185-189　2016/02

    ISSN： 0388-9408

  1532. 【新たに定義された"肝門部領域胆管癌"の診断と治療】 治療方針決定のためのCTおよびMRI

    片寄 友, 中川 圭, 益田 邦洋, 元井 冬彦, 海野 倫明

    胆と膵　37　(1)　29-36　2016/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1533. Lymph Nodes Surrounding the Inferior Mesenteric Vein

    Ishida Masaharu, Sakata Naoaki, Katagiri Munetoshi, Yoshimatsu Gunpei, Ohnuma Shinobu, Kitada Masaaki, Motoi Fuyuhiko, Naitoh Takeshi, Unno Michiaki

    The Japanese Journal of Gastroenterological Surgery　49　(4)　261-266　2016

    Publisher: The Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.2015.0148 　

    ISSN： 0386-9768

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    Purpose: In surgery for left colon cancer, there is no consistent idea about management of the inferior mesenteric vein (IMV). The IMV and its surrounding tissue is not considered as a subject of general dissection since the existence of the lymph nodes surrounding the IMV has not been clarified. The authors have previously encountered a case of descending colon cancer with metastasis to the lymph node surrounding the IMV. Based on this experience, the search for regional lymph nodes around the IMV was performed in 10 cadavers. Method: The tissue along the IMV was carefully examined in the cadavers. After gross observations, the IMV including the surrounding tissue was excised for microscopic search of the regional lymph nodes. Result: In 8 cadavers, lymph nodes surrounding the IMV were identified, and in 4 cadavers, the lymph nodes were located in the middle portion between the left colon artery and the splenic vein. Therefore, lymph nodes around the IMV were considered to exist at a relatively high frequency. Conclusion: Although lymph nodes around the IMV have been described in textbooks since the 1900s, they are not regarded as a significant issue in colon cancer surgery today. However, there is a possibility of metastasis of colon cancer to the lymph nodes along the IMV, if the left colonic lymphatic flow is obstructed in such tumor metastasis and the cancer cells travel through the accessory lymphatic path along the IMV. To clarify the clinical significance of the lymph nodes surrounding the IMV, the accumulation of future clinical data is necessary.

  1534. Genomic sequencing identifies ELF3 as a driver of ampullary carcinoma. Peer-reviewed

    Yachida S, Wood LD, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss MJ, Wolfgang CL, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban RH, Shibata T

    Cancer Cell　29　(2)　229-240　2016

    DOI： 10.1016/j.ccell.2015.12.012 　

  1535. National Clinical Database(消化器外科領域) Annual Report 2014

    若林 剛, 今野 弘之, 宇田川 晴司, 海野 倫明, 遠藤 格, 國崎 主税, 武冨 紹信, 丹黒 章, 橋本 英樹, 正木 忠彦, 本村 昇, 吉田 和弘, 渡邉 聡明, 宮田 裕章, 神谷 欣志, 平原 憲道, 後藤 満一, 森 正樹, 一般社団法人National Clinical Database

    日本消化器外科学会雑誌　48　(12)　1032-1044　2015/12

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1536. 多層的オミックス解析による肝再生分子メカニズムの解明

    佐藤 好宏, 加藤 恭丈, 松本 光代, 蝦名 貴行, 海野 倫明, 五十嵐 和彦

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[3P1029]-[3P1029]　2015/12

    Publisher: (公社)日本生化学会

  1537. Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study. International-journal Peer-reviewed

    Uemura K, Murakami Y, Satoi S, Sho M, Motoi F, Kawai M, Matsumoto I, Honda G, Kurata M, Yanagimoto H, Nishiwada S, Fukumoto T, Unno M, Yamaue H

    Annals of surgical oncology　22 Suppl 3　S1238-46　2015/12

    DOI： 10.1245/s10434-015-4618-9 　

    ISSN： 1068-9265

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    BACKGROUND: This study aimed to evaluate the impact of preoperative biliary drainage (PBD) on the long-term survival of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent pancreaticoduodenectomy (PD). METHODS: A multicenter observational study was performed using a common database of patients with resected PDAC from seven high-volume surgical institutions in Japan. RESULTS: Of 932 patients who underwent PD for PDAC, 573 (62 %) underwent PBD, including 407 (44 %) who underwent endoscopic biliary drainage (EBD) and 166 (18 %) who underwent percutaneous transhepatic biliary drainage (PTBD). The patients who did not undergo PBD and those who underwent EBD had a significantly better overall survival than those who underwent PTBD, with median survival times of 25.7 months (P < 0.001), 22.3 months (P = 0.001), and 16.7 months, respectively. Multivariate analysis showed that seven clinicopathologic factors, including the use of PTBD but not EBD, were independently associated with poorer overall survival. Furthermore, patients who underwent PTBD more frequently experienced peritoneal recurrence (23 %) than those who underwent EBD (10 %; P < 0.001) and those who did not undergo PBD (11 %; P = 0.001). Multivariate analysis demonstrated that the independent risk factors for peritoneal recurrence included surgical margin status (P < 0.001) and use of PTBD (P = 0.004). CONCLUSIONS: Use of PTBD, but not EBD, was associated with a poorer prognosis, with an increased rate of peritoneal recurrence among patients who underwent PD for PDAC.

  1538. Postoperative infectious complications after pancreatic resection Peer-reviewed

    K. Okano, T. Hirao, M. Unno, T. Fujii, H. Yoshitomi, S. Suzuki, S. Satoi, S. Takahashi, O. Kainuma, Y. Suzuki

    British Journal of Surgery　102　(12)　1551-1560　2015/11/01

    Publisher: John Wiley and Sons Ltd

    DOI： 10.1002/bjs.9919 　

    ISSN： 1365-2168 0007-1323

  1539. Proposed preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: A multi-center retrospective study. International-journal Peer-reviewed

    Matsumoto I, Murakami Y, Shinzeki M, Asari S, Goto T, Tani M, Motoi F, Uemura K, Sho M, Satoi S, Honda G, Yamaue H, Unno M, Akahori T, Kwon AH, Kurata M, Ajiki T, Fukumoto T, Ku Y

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　15　(6)　674-680　2015/11

    DOI： 10.1016/j.pan.2015.09.008 　

    ISSN： 1424-3903

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    BACKGROUND/OBJECTIVE: Although surgical resection remains the only chance for cure in patients with pancreatic ductal adenocarcinoma (PDAC), postoperative early recurrence (ER) is frequently encountered. The purpose of this study is to determine the preoperative predictive factors for ER after upfront surgical resection. METHODS: Between 2001 and 2012, 968 patients who underwent upfront surgery with R0 or R1 resection for PDAC at seven high-volume centers in Japan were retrospectively reviewed. ER was defined as relapse within 6 months after surgery. Study analysis stratified by resectable (R) and borderline resectable (BR) PDACs was conducted according to the National Comprehensive Cancer Network guidelines. RESULTS: ER occurred in 239 patients (25%) with a median survival time (MST) of 8.8 months. Modified Glasgow prognostic score = 2 (odds ratio (OR) 2.06, 95% confidence interval (CI) 1.05-3.95; P = 0.044), preoperative CA19-9 ≥300 U/ml (OR 1.94, 1.29-2.90; P = 0.003), and tumor size ≥30 mm (OR 1.72, 1.16-2.56; P = 0.006), were identified as preoperative independent predictive risk factors for ER in patients with R-PDAC. In the R-PDAC patients, MST was 35.5, 26.3, and 15.9 months in patients with 0, 1 and ≥2 risk factors, respectively. There were significant differences in overall survival between the three groups (P < 0.001). No preoperative risk factors were identified in BR-PDAC patients with a high rate of ER (39%). CONCLUSIONS: There is a high-risk subset for ER even in patients with R-PDAC and a simple risk scoring system is useful for prediction of ER.

  1540. [A Patient with Three-Year Relapse-Free Survival after Surgical Resection for Lung and Liver Metastases of Cholangiocarcinoma]. Peer-reviewed

    Aoki S, Mizuma M, Oyauchi M, Yoshida H, Okada R, Abe T, Sakata N, Nakagawa K, Hayashi H, Morikawa T, Motoi F, Naitoh T, Okada Y, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　42　(12)　1573-1575　2015/11

    ISSN： 0385-0684

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    We report of a patient with 3-year relapse-free survival after surgical resection for lung and liver metastases of distal cholangiocarcinoma (DCC). A quinquagenarianman was taken to a local hospital in October 2009 for yellow urine. He was diagnosed with DCC and was referred to our hospital for surgery. Pancreaticoduodenectomy was performed, and there was no residual tumor on histological examination. He did not receive any adjuvant therapy. One year 7 months after surgery, an isolated lung metastasis was identified on CT and was surgically removed. Six months after resection of the lung metastasis, a solitary liver metastasis was detected. Although systematic chemotherapy (gemcitabine plus S-1; 2 weeks treatment, 1 week drug free) was administered, the treatment was abandoned because of grade 3 (CTCAE v4.0) of skin disorders during the third course. Partial resection of the liver was performed in April 2012. Alternate-day treatment with S-1 was performed after resection of liver metastasis and is ongoing without adverse events. He has survived for more than 3 years without recurrence after liver resection. In this case of DCC metastasis, prognosis improved with surgical resection.

  1541. [Total Pelvic Exenteration for Local Recurrence of Rectal Cancer Appearing 12 Years after Curative Operation--A Case Report]. Peer-reviewed

    Obara M, Ohnuma S, Karasawa H, Watanabe K, Kudoh K, Ishida M, Imoto H, Aoki T, Tanaka N, Nagao M, Abe T, Musha H, Motoi F, Naitoh T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　42　(12)　2337-2339　2015/11

    ISSN： 0385-0684

  1542. ステージ4大腸癌の外科治療

    大沼 忍, 唐澤 秀明, 阿部 友哉, 青木 豪, 工藤 克昌, 石田 晶玄, 佐々木 宏之, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 坂田 直昭, 岡田 恭穂, 林 洋毅, 武者 宏昭, 中川 圭, 森川 孝則, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　48　(Suppl.2)　151-151　2015/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1543. 潰瘍性大腸炎手術後の排便機能およびQOLについての横断的・縦断的検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 土屋 堯裕, 河野 えみ子, 小野 智之, 大沼 忍, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　48　(Suppl.2)　138-138　2015/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1544. Extracellular Matrix and Growth Factors Improve the Efficacy of Intramuscular Islet Transplantation Peer-reviewed

    Haruyuki Tsuchiya, Naoaki Sakata, Gumpei Yoshimatsu, Masahiko Fukase, Takeshi Aoki, Masaharu Ishida, Yu Katayose, Shinichi Egawa, Michiaki Unno

    PLOS ONE　10　(10)　e0140910　2015/10

    DOI： 10.1371/journal.pone.0140910 　

    ISSN： 1932-6203

  1545. 多層的オミックス解析による肝再生分子メカニズムの解明

    佐藤 好宏, 加藤 恭丈, 松本 光代, 蝦名 真行, 海野 倫明, 五十嵐 和彦

    Organ Biology　22　(3)　74-74　2015/10

    Publisher: (一社)日本臓器保存生物医学会

    ISSN： 1340-5152

    eISSN： 2188-0204

  1546. 大動脈周囲リンパ節転移陽性膵癌の治療成績 多施設共同研究解析結果 Peer-reviewed

    庄 雅之, 村上 義昭, 元井 冬彦, 里井 壮平, 松本 逸平, 川井 学, 本田 五郎, 上村 健一郎, 柳本 泰明, 倉田 昌直, 後藤 直大, 赤堀 宇広, 海野 倫明, 山上 裕機, 中島 祥介

    日本臨床外科学会雑誌　76　(増刊)　725-725　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  1547. Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study Peer-reviewed

    Hideo Baba, Yoshifumi Baba, Shinji Uemoto, Kazuhiro Yoshida, Akio Saiura, Masayuki Watanabe, Yoshihiko Maehara, Eiji Oki, Yasuharu Ikeda, Hiroyuki Matsuda, Masakazu Yamamoto, Mitsuo Shimada, Akinobu Taketomi, Michiaki Unno, Kenichi Sugihara, Yutaka Ogata, Susumu Eguchi, Seigo Kitano, Kazuo Shirouzu, Yasumitsu Saiki, Hiroshi Takamori, Masaki Mori, Toshihiko Hirata, Go Wakabayashi, Norihiro Kokudo

    ONCOTARGET　6　(32)　34004-34013　2015/10

    DOI： 10.18632/oncotarget.5227 　

    ISSN： 1949-2553

    eISSN： 1949-2553

  1548. Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. Peer-reviewed

    Nakamura M, Wakabayashi G, Miyasaka Y, Tanaka M, Morikawa T, Unno M, Tajima H, Kumamoto Y, Satoi S, Kwon M, Toyama H, Ku Y, Yoshitomi H, Nara S, Shimada K, Yokoyama T, Miyagawa S, Toyama Y, Yanaga K, Fujii T, Kodera Y, Study Group of, JHBPS, JSEPS, Tomiyama Y, Miyata H, Takahara T, Beppu T, Yamaue H, Miyazaki M, Takada T

    Journal of hepato-biliary-pancreatic sciences　22　(10)　731-736　2015/10

    DOI： 10.1002/jhbp.268 　

    ISSN： 1868-6974

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    BACKGROUND: Laparoscopic distal pancreatectomy has been shown to be associated with favorable postoperative outcomes using meta-analysis. However, there have been no randomized controlled studies yet. This study aimed to compare laparoscopic and open distal pancreatectomy using propensity score-matching. METHODS: We retrospectively collected perioperative data of 2,266 patients who underwent distal pancreatectomy in 69 institutes from 2006-2013 in Japan. Among them, 2,010 patients were enrolled in this study and divided into two groups, laparoscopic distal pancreatectomy and open distal pancreatectomy. Perioperative outcomes were compared between the groups using unmatched and propensity matched analysis. RESULTS: After propensity score-matching, laparoscopic distal pancreatectomy was associated with favorable perioperative outcomes compared with open distal pancreatectomy, including higher rate of preservation of spleen and splenic vessels (P < 0.001); lower rates of intraoperative transfusion (P = 0.020), clinical grade of pancreatic fistula (International Study Group on Pancreatic Fistula grade B and C; P < 0.001), and morbidity (P < 0.001); and shorter hospital stay (P = 0.001), but a longer operative time (P < 0.001). CONCLUSIONS: Laparoscopic distal pancreatectomy was associated with more favorable perioperative outcomes than open distal pancreatectomy.

  1549. S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation. Peer-reviewed

    Nakagawa T, Araki T, Nakagawa M, Hirao A, Unno M, Nakayama K

    Molecular and cellular biology　35　(20)　3517-3527　2015/10

    DOI： 10.1128/MCB.00343-15 　

    ISSN： 0270-7306

  1550. Gastrointestinal toxicities of 5-fluorouracil increase the proportion of regulatory T cells in intestinal tract: advantages of alternate-day S-1 administration Peer-reviewed

    Taiki Kajiwara, Koh Miura, Shinobu Ohnuma, Miki Shimada, Toshihiro Komura, Masahide Toshima, Atsushi Kohyama, Katsuyoshi Kudoh, Sho Haneda, Hiroaki Musha, Takeshi Naitoh, Tetsuhiko Shirasaka, Michiaki Unno

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　20　(5)　913-921　2015/10

    DOI： 10.1007/s10147-015-0791-x 　

    ISSN： 1341-9625

    eISSN： 1437-7772

  1551. 消化器疾患と胆汁酸 病態・診断・治療への関わり 十二指腸空腸バイパス手術後ラットにおける血中胆汁酸上昇とNASH改善効果の検討

    土屋 堯裕, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　112　(臨増大会)　A779-A779　2015/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1552. 新規胆管癌糖蛋白質マーカー、WFA-positive sialtl-MUCIの臨床的意義 －多施設臨床試験の結果よりー

    大河内,信弘, 志田隆史, 樋口亮太, 山本雅一, 椰野正人, 露口利夫, 八坂貴宏, 田妻 進, 内山和久, 海野倫明, 松田厚志, 久野 敦, 成松 久, 正田純一

    第51回日本胆道学会学術集会プログラム・抄録集　189　2015/09

  1553. 【難治な胆道良性疾患の対処法を考える】 良性胆道疾患別の診断と治療(各論) 慢性膵炎による胆道狭窄 外科的治療． Invited

    坂田直昭, 江川新一, 青木 豪, 水間正道, 石田晶玄, 元井冬彦, 内藤 剛, 海野倫明

    肝胆膵　71　475-479　2015/09

    ISSN： 0389-4991

  1554. Mass spectrometry-based proteomic analysis of formalin-fixed paraffin-embedded extrahepatic cholangiocarcinoma. Peer-reviewed

    Maeda S, Morikawa T, Takadate T, Suzuki T, Minowa T, Hanagata N, Onogawa T, Motoi F, Nishimura T, Unno M

    Journal of hepato-biliary-pancreatic sciences　22　(9)　683-691　2015/09

    DOI： 10.1002/jhbp.262 　

    ISSN： 1868-6974

  1555. National Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma Predicts Overall Survival. International-journal Peer-reviewed

    Murakami Y, Satoi S, Sho M, Motoi F, Matsumoto I, Kawai M, Honda G, Uemura K, Yanagimoto H, Shinzeki M, Kurata M, Kinoshita S, Yamaue H, Unno M

    World journal of surgery　39　(9)　2306-2314　2015/09

    DOI： 10.1007/s00268-015-3096-3 　

    ISSN： 0364-2313

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    BACKGROUND: The aim of this study was to evaluate the validity of preoperative resectability status, as defined by the National Comprehensive Cancer Network (NCCN), from the viewpoint of overall survival. METHODS: A total of consecutive 704 patients with pancreatic head carcinoma who underwent pancreatoduodenectomy with upfront surgery at seven Japanese hospitals between 2001 and 2012 were evaluated retrospectively. According to the NCCN definition of preoperative resectability status, tumors were divided into resectable tumors without vascular contact (R group), resectable tumors with portal or superior mesenteric vein (PV/SMV) contact of ≦180° (R-PV group), borderline resectable(BR) tumors with PV/SMV contact of >180° (BR-PV group), and BR tumors with arterial contact (BR-A group). The relationship between the NCCN definition of preoperative resectability status and overall survival was analyzed. RESULTS: Of the 704 patients, 389, 114, 145, and 56 were classified into the R group, the R-PV group, the BR-PV group, and the BR-A group, respectively. Overall survival of the BR-PV and BR-A groups was significantly worse than that of the R group and R-PV groups (P < 0.05), although there was no significant difference in overall survival between the R group and the R-PV group (P = 0.310). Multivariate analysis revealed that PV/SMV contact of >180° (P = 0.008) and arterial contact (P < 0.001) were independent prognostic factors of overall survival. CONCLUSION: From the viewpoint of overall survival, the NCCN definition of preoperative resectability status was valid.

  1556. Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK. International-journal Peer-reviewed

    Nakano T, Saiki Y, Kudo C, Hirayama A, Mizuguchi Y, Fujiwara S, Soga T, Sunamura M, Matsumura N, Motoi F, Unno M, Horii A

    Biochemical and biophysical research communications　464　(4)　1084-1089　2015/09

    DOI： 10.1016/j.bbrc.2015.07.080 　

    ISSN： 0006-291X

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    The anti-tumor activity of gemcitabine (GEM) has been clinically proven in several solid tumors, including pancreatic cancer, biliary tract cancer, urinary bladder cancer, and non-small cell lung cancer. However, problems remain with issues such as acquisition of chemoresistance against GEM. GEM is activated after phosphorylation by deoxycytidine kinase (DCK) inside of the cell; thus, DCK inactivation is one of the important mechanisms for acquisition of GEM resistance. We previously investigated the DCK gene in multiple GEM resistant cancer cell lines and identified frequent inactivating mutations. In this study, we identified two crucial genetic alteration in DCK. (1) A total deletion of DCK in RTGBC1-TKB, an acquired GEM resistant cell line derived from a gall bladder cancer cell line TGBC1-TKB. (2) An E197K missense alteration of DCK in MKN28, a gastric cancer cell line; its acquired GEM resistant cancer cell line, RMKN28, showed a loss of the normal E197 allele. We introduced either normal DCK or altered DCK_E197K into RMKN28 and proved that only the introduction of normal DCK restored GEM sensitivity. Furthermore, we analyzed 104 healthy volunteers and found that none of them carried the same base substitution observed in MKN28. These results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of GEM resistance in RMKN28.

  1557. Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment. Peer-reviewed

    Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Ohtsuka H, Kamiie J, Abe T, Unno M, Terasaki T

    Molecular pharmaceutics　12　(9)　3282-3291　2015/09

    DOI： 10.1021/acs.molpharmaceut.5b00282 　

    ISSN： 1543-8384

  1558. Cholestatic Liver Injury After Biliary Reconstruction Impairs Transplanted Islet Viability and Function

    T. Hata, N. Sakata, G. Yoshimatsu, H. Tsuchiya, M. Fukase, M. Ishida, T. Aoki, Y. Katayose, S. Egawa, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　15　(8)　2085-2095　2015/08

    DOI： 10.1111/ajt.13266 　

    ISSN： 1600-6135

    eISSN： 1600-6143

  1559. 胆道疾患と脂質代謝異常 診断と治療を含めて 十二指腸空腸バイパス手術後ラットにおける血中胆汁酸上昇とNASH改善効果の検討

    土屋 堯裕, 内藤 剛, 海野 倫明

    胆道　29　(3)　413-413　2015/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1560. Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway. International-journal Peer-reviewed

    Douchi D, Ohtsuka H, Ariake K, Masuda K, Kawasaki S, Kawaguchi K, Fukase K, Oikawa M, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M

    Cancer letters　365　(1)　132-140　2015/08

    DOI： 10.1016/j.canlet.2015.05.023 　

    ISSN： 0304-3835

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    The canonical Wnt/β-catenin signaling pathway has been shown to promote the epithelial-mesenchymal transition (EMT), which is a crucial process in multiple embryonic developmental processes and the progression of carcinomas. We recently provided evidence that leucine-rich repeat flightless-1-interacting protein 1 (LRRFIP1) promotes cancer metastasis and invasion. In the present study, we identified the signaling elements targeted by LRRFIP1 for promotion of the EMT in pancreatic and lung cancer. LRRFIP1 silencing reversed the EMT, as shown by increased expression of E-cadherin (an epithelial marker) and decreased expression of vimentin (a mesenchymal marker). Silencing of LRRFIP1 up-regulated phosphorylation of β-catenin and decreased its nuclear localization by targeting the β-catenin destruction complex. The expression of β-catenin and E-cadherin in the plasma membrane fraction was increased in LRRFIP1 silenced cancer cells, and the migration and invasion capabilities were strongly inhibited. In addition, this protein was highly expressed at the invasion front of malignant tissue collected from pancreatic cancer patients. Consequently, our data strongly suggested that LRRFIP1 played an important role in the invasion of carcinoma cells. Our data provide experimental evidence that LRRFIP1 is an attractive candidate for targeted therapy in human cancers.

  1561. 膵全摘術後1年の体重減少に影響する危険因子

    志村 充広, 水間 正道, 畠 達夫, 岡田 良, 阿部 友哉, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　P-4　2015/07

    Publisher: (一社)日本消化器外科学会

  1562. 尾側膵切除術における断端膵管胃粘膜吻合の有用性 多施設共同ランダム化比較試験 Peer-reviewed

    上村 健一郎, 里井 壮平, 元井 冬彦, 橋本 泰司, 柳本 泰明, 深瀬 耕二, 權 雅憲, 海野 倫明, 村上 義昭

    日本消化器外科学会総会　70回　P-8　2015/07

    Publisher: (一社)日本消化器外科学会

  1563. Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs. Peer-reviewed

    Someya S, Nagao M, Shibata C, Tanaka N, Sasaki H, Kikuchi D, Miyachi T, Naitoh T, Unno M

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　19　(7)　1342-1349　2015/07

    DOI： 10.1007/s11605-015-2813-4 　

    ISSN： 1091-255X

  1564. 切除企図膵癌に対する術前・術後補助化学療法． Invited

    元井冬彦, 岡田 良, 川口 桂, 益田邦洋, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野倫明

    肝胆膵　71　(1)　63-71　2015/07

    ISSN： 0389-4991

  1565. [Occupational cholangiocarcinoma in a printer that responded to neoadjuvant chemoradiotherapy]. Peer-reviewed

    Nakagawa K, Katayose Y, Ishida K, Hayashi H, Morikawa T, Yoshida H, Motoi F, Naitoh T, Kubo S, Unno M

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology　112　(7)　1341-1347　2015/07

    Publisher: The Japanese Society of Gastroenterology

    DOI： 10.11405/nisshoshi.112.1341 　

    ISSN： 0446-6586

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    A 42-year-old man working at a printing company was referred to our hospital for examination and treatment of icterus. We diagnosed resectable hilar cholangiocarcinoma and provided neoadjuvant chemoradiotherapy, extended right hepatectomy, and extrahepatic bile duct resection. A detailed history revealed that he had used 1,2-dichloropropane as part of his work as an offset colour proof-printer, and he has subsequently been recognized as having occupational cholangiocarcinoma. He has survived without recurrence for more than 2 and half years since the liver resection. In the present report, we describe our valuable experience of neoadjuvant chemoradiotherapy for occupational cholangiocarcinoma.

  1566. Nerve Growth Factor Improves Survival and Function of Transplanted Islets Via TrkA-mediated beta Cell Proliferation and Revascularization Peer-reviewed

    Tatsuo Hata, Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Masahiko Fukase, Masaharu Ishida, Takeshi Aoki, Yu Katayose, Shinichi Egawa, Michiaki Unno

    TRANSPLANTATION　99　(6)　1132-1143　2015/06

    DOI： 10.1097/TP.0000000000000655 　

    ISSN： 0041-1337

    eISSN： 1534-6080

  1567. Enhanced Ultrasonography Using a Nano/Microbubble Contrast Agent for Islet Transplantation

    N. Sakata, N. Sax, G. Yoshimatsu, H. Tsuchiya, S. Kato, T. Aoki, M. Ishida, Y. Katayose, S. Egawa, T. Kodama, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　15　(6)　1531-1542　2015/06

    DOI： 10.1111/ajt.13152 　

    ISSN： 1600-6135

    eISSN： 1600-6143

  1568. 87歳肝血管腫自然破裂の1例 Peer-reviewed

    志村 充広, 水間 正道, 元井 冬彦, 片寄 友, 高瀬 圭, 海野 倫明

    日本臨床外科学会雑誌　76　(6)　1469-1473　2015/06

    DOI： 10.3919/jjsa.76.1469 　

  1569. Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients. Peer-reviewed

    Sho M, Murakami Y, Motoi F, Satoi S, Matsumoto I, Kawai M, Honda G, Uemura K, Yanagimoto H, Kurata M, Fukumoto T, Akahori T, Kinoshita S, Nagai M, Nishiwada S, Unno M, Yamaue H, Nakajima Y

    Journal of gastroenterology　50　(6)　694-702　2015/06

    DOI： 10.1007/s00535-014-1005-4 　

    ISSN： 0944-1174

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    BACKGROUND: The prognosis of pancreatic cancer patients with metastatic para-aortic lymph node (PALN) has been reported to be extremely poor. In general, PALN metastasis has been considered as a contraindication for pancreatic resection. The aim of this study was to reevaluate the postoperative prognostic value of PALN metastasis in pancreatic cancer and to determine the validity of pancreatic surgery. METHODS: Retrospective multicenter analysis of 882 patients who have undergone curative-intent pancreatic resection with pathological evaluation of PALNs for pancreatic ductal adenocarcinoma between 2001 and 2012 was conducted. Clinicopathological data and outcomes were evaluated with univariate and multivariate analysis. RESULTS: In total, 102 (12.4 %) patients had positive metastasis in PALN. Patients with metastatic PALN had significantly poorer survival than those without (17 vs. 23 months; p < 0.001). Multivariable analysis of 822 patients identified adjuvant chemotherapy, primary tumor status, regional lymph node metastasis, portal vein invasion, pre- and post-operative serum CA19-9 levels, and tumor grade as independent prognostic factors. In contrast, PALN metastasis did not have a significant prognostic value. Furthermore, the multivariate prognostic analysis in patients with PALN metastasis revealed that adjuvant chemotherapy and the number of metastatic PALN were significantly associated with long-term survival. Lung metastasis as initial recurrence was observed more often in patients with PALN metastasis in comparison with those without. CONCLUSIONS: Some pancreatic cancer patients with metastatic PALN may survive for longer than expected after pancreatectomy. Adjuvant chemotherapy and the number of metastatic PALN were critical factors for long-term survival of those patients.

  1570. Early experience of robotic surgery for type I congenital dilatation of the bile duct. Peer-reviewed

    Naitoh T, Morikawa T, Tanaka N, Aoki T, Ohtsuka H, Okada T, Sakata N, Ohnuma S, Nakagawa K, Hayashi H, Musha H, Yoshida H, Motoi F, Katayose Y, Unno M

    Journal of robotic surgery　9　(2)　143-148　2015/06

    DOI： 10.1007/s11701-015-0504-5 　

    ISSN： 1863-2483

  1571. Borderline resectable膵癌に対する術前治療． Invited

    元井冬彦, 岡田 良, 川口 桂, 益田邦洋, 石田晶玄, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川新一, 海野倫明

    外科　77　(5)　517-522　2015/05

    ISSN： 0016-593X

  1572. 肝胆膵 膵管内腺癌患者の長期生存率に対する術前胆道ドレナージの効果に関する多施設共同観察研究(A multicenter observational study of potential effect of preoperative biliary drainage on long-term survival in the patients with pancreatic ductal adenocarcinoma) Peer-reviewed

    上村 健一郎, 村上 義昭, 里井 壮平, 庄 雅之, 元井 冬彦, 川井 学, 松本 逸平, 本田 五郎, 倉田 昌直, 柳本 泰明, 赤堀 宇広, 浅利 貞毅, 海野 倫明, 山上 裕機

    日本外科学会定期学術集会抄録集　115回　IS-4　2015/04

    Publisher: (一社)日本外科学会

  1573. 肝胆膵 切除可能膵癌の術前療法臨床試験における術前切除可能性判定標準化の重要性 Peer-reviewed

    村上 義昭, 里井 壯平, 元井 冬彦, 川井 学, 本田 五郎, 庄 雅之, 松本 逸平, 上村 健一郎, 倉田 昌直, 赤堀 宇弘, 柳本 泰明, 浅利 貞毅, 海野 倫明, 山上 裕機

    日本外科学会定期学術集会抄録集　115回　OP-1　2015/04

    Publisher: (一社)日本外科学会

  1574. 続発性ヘモクロマトーシスを背景とした肝細胞癌門脈腫瘍栓再発に対し放射線治療が著効した1例(続報) Peer-reviewed

    井上 亨悦, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 神宮 啓一, 海野 倫明

    肝臓　56　(4)　150-156　2015/04

    DOI： 10.2957/kanzo.41.823 　

  1575. Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition Peer-reviewed

    Miyazaki Masaru, Yoshitomi Hideyuki, Miyakawa Shuichi, Uesaka Katsuhiko, Unno Michiaki, Endo Itaru, Ota Takehiro, Ohtsuka Masayuki, Kinoshita Hisafumi, Shimada Kazuaki, Shimizu Hiroaki, Tabata Masami, Chijiiwa Kazuo, Nagino Masato, Hirano Satoshi, Wakai Toshifumi, Wada Keita, Iasayama Hiroyuki, Okusaka Takuji, Tsuyuguchi Toshio, Fujita Naotaka, Furuse Junji, Yamao Kenji, Murakami Koji, Yamazaki Hideya, Kijima Hiroshi, Nakanuma Yasuni, Yoshida Masahiro, Takayashiki Tsukasa, Takada Tadahiro

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　22　(4)　249-273　2015/04

    DOI： 10.1002/jhbp.233 　

    ISSN： 1868-6974

  1576. 腹腔鏡下尾側膵切除術の手術手技． Invited

    森川孝則, 内藤 剛, 青木 豪, 石田昌玄, 深瀬耕二, 水間正道, 坂田直昭, 中川 圭, 林 洋毅, 元井冬彦, 片寄 友, 海野倫明

    消化器外科　38　(4)　511-519　2015/04

    ISSN： 0387-2645

  1577. A Retrospective Study of 45 Patients Who Underwent Surgical Treatment for Local Recurrence of Rectal Cancer Peer-reviewed

    Ohnuma Shinobu, Karasawa Hideaki, Watanabe Kazuhiro, Nagao Munenori, Abe Tomoya, Naitoh Takeshi, Unno Michiaki

    GASTROENTEROLOGY　148　(4)　S1153-S1154　2015/04

    ISSN： 0016-5085

  1578. Which Is the Better Procedure for the Closure of Diverting Loop Ileostomy After Ileal Pouch Anal Anastomosis for Ulcerative Colitis; Stapled or Hand-Sewn Anastomosis? Peer-reviewed

    Nagao Munenori, Watanabe Kazuhiro, Karasawa Hideaki, Abe Tomoya, Ohnuma Shinobu, Musha Hiroaki, Shibata Chikashi, Naitoh Takeshi, Unno Michiaki

    GASTROENTEROLOGY　148　(4)　S1186　2015/04

    ISSN： 0016-5085

  1579. 【進行膵・胆道癌における血管合併切除の諸問題】 肝門部領域胆管癌における門脈浸潤例の切除戦略

    益田 邦洋, 中川 圭, 元井 冬彦, 海野 倫明

    胆と膵　36　(3)　213-219　2015/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1580. Classification of biliary tract cancers established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery: 3rd English edition Peer-reviewed

    Miyazaki Masaru, Ohtsuka Masayuki, Miyakawa Shuichi, Nagino Masato, Yamamoto Masakazu, Kokudo Norihiro, Sano Keiji, Endo Itaru, Unno Michiaki, Chijiiwa Kazuo, Horiguchi Akihiko, Kinoshita Hisafumi, Oka Masaaki, Kubota Keiichi, Sugiyama Masanori, Uemoto Shinji, Shimada Mitsuo, Suzuki Yasuyuki, Inui Kazuo, Tazuma Susumu, Furuse Junji, Yanagisawa Akio, Nakanuma Yasuni, Kijima Hiroshi, Takada Tadahiro

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　22　(3)　181-196　2015/03

    DOI： 10.1002/jhbp.211 　

    ISSN： 1868-6974

  1581. [Treatment strategy of the gallbladder cancer]. Peer-reviewed

    Katayose Y, Hayashi H, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　572-575　2015/03

    ISSN： 0047-1852

  1582. [Surgical treatment for gallbladder cancer]. Peer-reviewed

    Yoshida H, Hayashi H, Katayose Y, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　576-579　2015/03

    ISSN： 0047-1852

  1583. [Prognostic factors of gallbladder cancer]. Peer-reviewed

    Hayashi H, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　610-614　2015/03

    ISSN： 0047-1852

  1584. [Outcomes of surgical treatment for gallbladder cancer: differences between Japan and western countries]. Peer-reviewed

    Ohtsuka H, Hayashi H, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　605-609　2015/03

    ISSN： 0047-1852

  1585. [Surgical management of intestinal Crohn's disease]. Peer-reviewed

    Funayama Y, Suzuki H, Takahashi K, Haneda S, Watanabe K, Ikezawa F, Unno M

    Nihon Geka Gakkai zasshi　116　(2)　94-98　2015/03

    ISSN： 0301-4894

  1586. 子宮内避妊器具が原因と思われたS状結腸穿通を伴う腹部放線菌症の1例 Peer-reviewed

    土屋朗之, 田中直樹, 坂田直昭, 森川孝則, 内藤 剛, 海野倫明

    日臨外会誌　76　(3)　603-607　2015/03

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.76.603 　

    ISSN： 1345-2843

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    A woman in her sixties, who had an abdominal abscess with a long-term placement of an intrauterine contraceptive device and received removal of the device, had multiple abdominal masses including a left ovarian mass. An ovarian tumor with multiple peritoneal metastases was suspected, and she received detailed examinations. During the examinations, the ovarian mass was found to have penetrated into the sigmoid colon and then she had to undergo an emergency operation because of acute peritonitis with severe inflammation due to an enlargement of the abdominal mass. Resection of the uterus and ovarium with drainage of the abscess and temporary ileostomy was performed. Numerous Gram-positive bacilli were observed in the resected tissue, and Actinomyces israelii was detected by the bacterial culture. In this case, it was considered that abdominal actinomycosis might be caused by the long-term placement of the intrauterine contraceptive device. After oral administration of penicillin for postoperative 6 months, she has had no recurrence as of 2 years and 8 months.<BR>This case report suggests that the long-term placement of an intrauterine contraceptive device can cause abdominal actinomycosis.

  1587. [Efficacy of neoadjuvant chemotherapy for pancreatic carcinoma planned resection]. Peer-reviewed

    Motoi F, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　152-158　2015/03

    ISSN： 0047-1852

  1588. Feasibility Assessment of Modified FOLFOX-6 as adjuvant treatment after resection of liver metastases from colorectal cancer: analyses of a multicenter phase II clinical trial (Miyagi-HBPCOG Trial-001). Peer-reviewed

    Katayose Y, Yamamoto K, Nakagawal K, Takemura S, Takahashi M, Nakamura R, Shimamura H, Rikiyama T, Egawa S, Yoshda H, Motoi F, Naitoh T, Unno M

    Hepato-gastroenterology　62　(138)　303-308　2015/03

    DOI： 10.5754/hge141044 　

    ISSN： 0172-6390

  1589. 術式決定にMDCTが有用であった広範囲胆管癌の1例 Peer-reviewed

    海野 倫明, 吉田, 寛, 菅野, 敦, 藤島 史喜

    胆道　29　(1)　163-166　2015/03

    DOI： 10.11210/tando.29.163 　

  1590. Clinicopathological features and surgical outcomes of adenosquamous carcinoma of the pancreas: a retrospective analysis of patients with resectable stage tumors. Peer-reviewed

    Komatsu H, Egawa S, Motoi F, Morikawa T, Sakata N, Naitoh T, Katayose Y, Ishida K, Unno M

    Surgery today　45　(3)　297-304　2015/03

    DOI： 10.1007/s00595-014-0934-0 　

    ISSN： 0941-1291

  1591. 九死に一生を得た膵頭十二指腸切除術後出血の1例 Peer-reviewed

    志村 充広, 岡田 恭穂, 水間 正道, 吉田 寛, 林 洋毅, 中川 圭, 藪内 伸一, 工藤 克昌, 土屋 堯裕, 小林 実, 阿部 友哉, 岡田 良, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　35　(2)　392-392　2015/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1592. Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects. Peer-reviewed

    Komura T, Miura K, Shirasaka T, Ohnuma S, Shimada M, Kajiwara T, Fujishima F, Philchenkov A, Nakagawa K, Kudoh K, Haneda S, Toshima M, Kohyama A, Musha H, Naitoh T, Shibata C, Unno M

    International journal of clinical oncology　20　(1)　117-125　2015/02

    DOI： 10.1007/s10147-014-0699-x 　

    ISSN： 1341-9625

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    BACKGROUND: A clinical trial of S-1 with leucovorin (S-1/LV) in metastatic colorectal cancer (CRC) patients demonstrated promising efficacy; however, the gastrointestinal toxicities were so severe that it has not been applied in the clinical setting. On the other hand, alternate-day administration of S-1 has been proposed to attenuate the adverse events without reducing its anticancer activity. Our present study was conducted to confirm the feasibility of alternate-day administration of S-1/LV in in vivo xenograft tumor models. METHODS: Mice were treated with S-1/LV in a daily group (2 weeks of administration followed by 2 weeks of withdrawal) or an alternate-day group (administration on alternate days for 4 weeks), then the mice were killed and the xenograft tumors were resected. We compared body weight changes, condition of feces, mucosal injury and myelosuppression and assessed adverse reactions, tumor volume, tumor growth inhibition (TGI) and expression of Ki67, TUNEL, cIAP2 and XIAP to evaluate the antitumor activity and tumor apoptosis. RESULTS: Severe weight loss, diarrhea, mucosal injury and myelosuppression were observed only in the daily group; however, some myelosuppression was also observed in the alternate-day group. The TGI in the alternate-day group was better than in the daily group, possibly resulting from apoptosis due to the suppression of cIAP2 but not XIAP. CONCLUSION: Our findings suggest that alternate-day administration of S-1/LV for CRC treatment can achieve high antitumor activity without severe adverse reactions, and we propose that clinical trials with this regimen should be conducted in CRC patients.

  1593. Reappraisal of peritoneal washing cytology in 984 patients with pancreatic ductal adenocarcinoma who underwent margin-negative resection. International-journal Peer-reviewed

    Satoi S, Murakami Y, Motoi F, Uemura K, Kawai M, Kurata M, Sho M, Matsumoto I, Yanagimoto H, Yamamoto T, Mizuma M, Unno M, Hashimoto Y, Hirono S, Yamaue H, Honda G, Nagai M, Nakajima Y, Shinzeki M, Fukumoto T, Kwon AH

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　19　(1)　6-14; discussion 14　2015/01

    DOI： 10.1007/s11605-014-2637-7 　

    ISSN： 1091-255X

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    OBJECTIVE: The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection. METHODS: In a 2001-2011 database from seven high-volume surgical institutions in Japan, 69 patients (7%) had positive CY (CY+ group) indicative of M1 disease and 915 patients had negative CY (CY- group). Clinicopathological data and survival were compared between groups. RESULTS: Significant correlations between CY+ and high CA19-9 level, pancreatic body and tail cancer, lymph node metastasis, and a lower frequency of R0 resection were observed. Overall survival (OS) of CY+ patients was significantly worse than that of CY- patients (median survival time [MST], 16 vs. 25 months; 3-year OS rate, 6 vs. 37%; p < 0.001). CY+ patients had a significantly higher rate of post-operative peritoneal carcinomatosis than CY- patients (48 vs. 21%; p < 0.001). Administration of adjuvant chemotherapy did not provide a favorable survival outcome to CY+ patients. The current study showed that patients with M1 disease had acceptable MST after margin-negative resection and a high incidence of peritoneal carcinomatosis within 3 years after surgery, resulting in decreased long-term survival. The development of a new strategy to control peritoneal carcinomatosis when surgical resection is performed in such patients is required.

  1594. 術前戦略 術前chemo (radiation) therapy Invited

    片寄 友, 吉田 寛, 中川 圭, 林 洋毅, 森川孝則, 岡田恭穂, 坂田直昭, 元井冬彦, 内藤 剛, 海野倫明

    臨床外科　70　(1)　18-22　2015/01

    ISSN： 0386-9857

  1595. The co-transplantation of bone marrow derived mesenchymal stem cells reduced inflammation in intramuscular islet transplantation. Peer-reviewed

    Yoshimatsu G, Sakata N, Tsuchiya H, Minowa T, Takemura T, Morita H, Hata T, Fukase M, Aoki T, Ishida M, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M

    PloS one　10　(2)　e0117561　2015

    DOI： 10.1371/journal.pone.0117561 　

  1596. Long-term outcomes after extrahepatic excision of congenital choladocal cysts: 30 years of experience at a single center. Peer-reviewed

    Ohtsuka H, Fukase K, Yoshida H, Motoi F, Hayashi H, Morikawa T, Okada T, Nakagawa K, Naitoh T, Katayose Y, Unno M

    Hepato-gastroenterology　62　(137)　1-5　2015/01

    DOI： 10.5754/hge14139 　

    ISSN： 0172-6390

  1597. Progesterone Receptor Isoforms A and B in Pancreatic Neuroendocrine Tumor. Peer-reviewed

    Yazdani S, Kasajima A, Ogata H, Felizola SJ, Nakamura Y, Onodera Y, Watanabe M, Motoi F, Unno M, Sasano H

    Neuroendocrinology　101　(4)　309-320　2015

    DOI： 10.1159/000381455 　

    ISSN： 0028-3835

  1598. A long term survival case of hilar cholangiocarcinoma with multiple metastases treated with chemotherapy and operation Peer-reviewed

    Keiichi Shirasaki, Takanori Morikawa, Hideo Otsuka, Yu Katayose, Michiaki Unno

    Japanese Journal of Cancer and Chemotherapy　41　(12)　1530-1532　2014/11/01

    Publisher: Japanese Journal of Cancer and Chemotherapy Publishers Inc.

    ISSN： 0385-0684

  1599. Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma Peer-reviewed

    Kubo Shoji, Kinoshita Masahiko, Takemura Shigekazu, Tanaka Shogo, Shinkawa Hiroji, Nishioka Takayoshi, Hamano Genya, Ito Tokuji, Abue Makoto, Aoki Masaru, Nakagawa Kei, Unno Michiaki, Hijioka Susumu, Fujiyoshi Toshihisa, Shimizu Yasuhiro, Mizuguchi Toru, Shirabe Ken, Nishie Akihiro, Oda Yoshinao, Takenaka Kenji, Kobarai Tomonari, Hisano Terumasa, Saiura Akio, Numao Hiroshi, Toda Mayura, Kuwae Yuko, Nakanuma Yasuni, Endo Ginji

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　21　(11)　809-817　2014/11

    DOI： 10.1002/jhbp.137 　

    ISSN： 1868-6974

  1600. 肝門部胆管癌多発肝転移に対し肝切除およびGemcitabine、S-1療法が奏効し長期生存を得た1例 Peer-reviewed

    白崎 圭一, 森川 孝則, 大塚 英郎, 片寄 友, 海野 倫明

    癌と化学療法　41　(12)　1530-1532　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1601. [Tips and pitfalls of Frey's procedure for chronic pancreatitis]. Peer-reviewed

    Motoi F, Egawa S, Unno M

    Nihon Geka Gakkai zasshi　115　(6)　345-347　2014/11

    ISSN： 0301-4894

  1602. The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification. International-journal Peer-reviewed

    Unno J, Kanno A, Masamune A, Kasajima A, Fujishima F, Ishida K, Hamada S, Kume K, Kikuta K, Hirota M, Motoi F, Unno M, Shimosegawa T

    Scandinavian journal of gastroenterology　49　(11)　1367-1374　2014/11

    DOI： 10.3109/00365521.2014.934909 　

    ISSN： 0036-5521

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    BACKGROUND: We assessed the controversial topic of using 22-gauge needles in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis and evaluation of Ki67 labeling indices (Ki67LI) of pancreatic neuroendocrine tumors (pNET). METHODS: Thirty-eight patients with pNET who underwent EUS-FNA between January 1, 2008 and December 31, 2012 were enrolled in this study. When available, the Ki67LI and WHO classifications obtained by EUS-FNA and surgical resection were compared. RESULTS: EUS-FNA with a 22-gauge needle acquired sufficient histological sample to correctly diagnose pNET in 35 cases (92.1%). Both EUS-FNA and surgical histological specimens were available for 19 cases, and grading classes of the 2 procedures were consistent in 17 cases (89.5%) according to the WHO classification based on the Ki67LI. Tumor size was associated with a difference in the Ki67LI between the 2 procedures, although the Ki67LI was almost completely consistent for tumors less than 18 mm in size. CONCLUSIONS: EUS-FNA with a 22-gauge needle is a safe and highly accurate technique for the diagnosis of pNET. There was a clear correlation between the Ki67LI of histological specimens acquired by EUS-FNA and surgery. EUS-FNA with a 22-gauge needle is useful to predict the WHO classification of pNET.

  1603. [A case of advanced gallbladder cancer with mediastinum lymph node metastasis successfully treated with multimodality therapy]. Peer-reviewed

    Katagiri M, Katayose Y, Yabuuchi S, Karasawa H, Sato J, Morikawa T, Motoi F, Naito T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　41　(12)　1527-1529　2014/11

    ISSN： 0385-0684

  1604. [A case of pathological complete response to lt. Lateral lymph node metastasis from lower rectal cancer by S-1 combined neoadjuvant chemoradiotherapy]. Peer-reviewed

    Kimura S, Ohnuma S, Karasawa H, Aoki T, Kudoh K, Watanabe K, Tanaka N, Nagao M, Abe T, Musha H, Morikawa T, Motoi F, Katayose Y, Naitoh T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　41　(12)　1560-1562　2014/11

    ISSN： 0385-0684

  1605. [A case report of complete pathological response of a locally advanced rectal cancer after long term chemotherapy]. Peer-reviewed

    Kobayashi M, Ohnuma S, Kato S, Karasawa H, Aoki T, Kudo K, Tanaka N, Watanabe K, Nagao M, Abe T, Musha H, Morikawa T, Motoi F, Katayose Y, Naito T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　41　(12)　1755-1757　2014/11

    ISSN： 0385-0684

  1606. [A case of pancreatic cancer with local recurrence and liver metastases eight years after surgery]. Peer-reviewed

    Taniguchi H, Mizuma M, Motoi F, Abe T, Okada R, Kawaguchi K, Karasawa H, Masuda K, Yabuuchi S, Fukase K, Sakata N, Okada T, Nakagawa K, Hayashi H, Morikawa T, Yoshida H, Naito T, Katayose Y, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　41　(12)　2193-2195　2014/11

    ISSN： 0385-0684

  1607. [Two cases of advanced gastric cancer achieved pathological complete response by preoperative chemotherapy with S-1 plus weekly low-dose CDDP]. Peer-reviewed

    Kono E, Tanaka N, Kudo K, Musha H, Tsuchiya T, Miyachi T, Nagao M, Kajiwara T, Kimura S, Karasawa H, Aoki T, Abe T, Ohnuma S, Nakagawa K, Morikawa T, Yoshida H, Motoi F, Katayose Y, Naito T, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　41　(12)　2279-2281　2014/11

    ISSN： 0385-0684

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    We report 2 cases of resectable advanced gastric cancer who achieved pathological complete response by preoperative chemotherapy with S-1 plus weekly low-dose cisplatin (CDDP). S-1 (80 mg/m²)was administered consecutively for 21 days followed by 14 days' rest, with CDDP (25mg/m²) injected on days 1, 8, and 21. Case 1: A man in his 70s diagnosed with cStage III gastric cancer with lymph node metastases received 2 courses of preoperative chemotherapy with S-1 plus weekly low-dose CDDP followed by total gastrectomy with D2 lymph node dissection. Case 2: A man in his 60s diagnosed with cStage III gastric cancer with lymph node metastases received 4 courses of preoperative chemotherapy with S-1 plus weekly low-dose CDDP followed by total gastrectomy with D2 lymph-node dissection. In both cases, postoperative pathological examination revealed no cancer cells in the resected stomach and lymph nodes. The therapeutic effect of preoperative chemotherapy was assessed as Grade 3. With this regimen, we accomplished preoperative chemotherapy successfully without inpatient care. This regimen can be a promising option as preoperative chemotherapy for advanced gastric cancer.

  1608. 【ERAS時代の周術期管理マニュアル】 術式別の術前・術中・術後管理 肝 化学療法後の肝切除

    益田 邦洋, 吉田 寛, 片寄 友, 海野 倫明

    臨床外科　69　(11)　162-164　2014/10

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1407200020 　

    ISSN： 0386-9857

  1609. Gastrointestinal toxicities of 5-FU increase the proportion of regulatory T cells in murine intestinal tract: Advantages of alternate-day S-1 administration Peer-reviewed

    Taiki Kajiwara, Koh Miura, Shinobu Ohnuma, Tetsuhiko Shirasaka, Toshihiro Komura, Masahide Toshima, Atsushi Kohyama, Katsuyoshi Kudoh, Sho Haneda, Hiroaki Musha, Fuyuhiko Motoi, Yu Katayose, Takeshi Naitoh, Michiaki Unno

    CANCER RESEARCH　74　(19)　2014/10

    DOI： 10.1158/1538-7445.AM2014-631 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1610. Single nucleotide polymorphisms of DPYD and MTHFR predict adverse events associated with 5-fluorouracil in patients with gastrointestinal cancer Peer-reviewed

    Toshima Masahide, Ohnuma Shinobu, Tanaka Michiiro, Miura Koh, Fujibuchi Wataru, Kajiwara Taiki, Komura Toshihiro, Musha Hiroaki, Haneda Sho, Kudoh Katsuyoshi, Kohyama Atsushi, Naitoh Takeshi, Unno Michiaki

    CANCER RESEARCH　74　(19)　2014/10/01

    DOI： 10.1158/1538-7445.AM2014-2832 　

    ISSN： 0008-5472

  1611. Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: A shorter drug-free interval leads to more efficient antitumor effects Peer-reviewed

    Komura Toshihiro, Ohnuma Shinobu, Miura Koh, Shirasaka Tetsuhiko, Kajiwara Taiki, Kudoh Katsuyoshi, Haneda Sho, Toshima Masahide, Kohyama Atsushi, Musha Hiroaki, Naitoh Takeshi, Katayose Yu, Unno Michiaki

    CANCER RESEARCH　74　(19)　2014/10/01

    DOI： 10.1158/1538-7445.AM2014-792 　

    ISSN： 0008-5472

  1612. Erratum: Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice (Biochemical and Biophysical Research Communications (2014) 447 (346-351)) Peer-reviewed

    Yoichi Haji, Makiko Suzuki, Kunihiko Moriya, Takanori So, Katsuto Hozumi, Masamichi Mizuma, Michiaki Unno, Naoto Ishii

    Biochemical and Biophysical Research Communications　452　(1)　206-207　2014/09/12

    Publisher: Academic Press Inc.

    DOI： 10.1016/j.bbrc.2014.08.099 　

    ISSN： 1090-2104 0006-291X

  1613. LRRFIP1の発現抑制はWnt/β-カテニン経路を抑制することによりReversing EMTを起こす(Silencing LRRFIP1 reverses epithelial-mesenchymal transition through inhibition of Wnt/β-catenin signaling pathway)

    堂地 大輔, 大塚 英郎, 有明 恭平, 川崎 修平, 川口 桂, 益田 邦洋, 深瀬 耕二, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本癌学会総会記事　73回　P-2162　2014/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  1614. Safety of postoperative thromboprophylaxis after major hepatobiliary-pancreatic surgery in Japanese patients. Peer-reviewed

    Hayashi H, Morikawa T, Yoshida H, Motoi F, Okada T, Nakagawa K, Mizuma M, Naitoh T, Katayose Y, Unno M

    Surgery today　44　(9)　1660-1668　2014/09

    DOI： 10.1007/s00595-014-0890-8 　

    ISSN： 0941-1291

  1615. Proposal of a new staging system for mass-forming intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery Peer-reviewed

    Takahiro Uenishi, Shunichi Ariizumi, Taku Aoki, Tomoki Ebata, Masayuki Ohtsuka, Eiichi Tanaka, Hiroshi Yoshida, Satoru Imura, Masaki Ueno, Norihiro Kokudo, Masato Nagino, Satoshi Hirano, Shoji Kubo, Michiaki Unno, Mitsuo Shimada, Hiroki Yamaue, Masakazu Yamamoto, Masaru Miyazaki, Tadahiro Takada

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　21　(7)　499-508　2014/07

    DOI： 10.1002/jhbp.92 　

    ISSN： 1868-6974

    eISSN： 1868-6982

  1616. 手術手技 腹腔鏡下脾動静脈温存膵体尾部切除術の手術手技 Peer-reviewed

    森川 孝則, 内藤 剛, 青木 豪, 元井 冬彦, 片寄 友, 海野 倫明

    手術　68　(8)　1101-1106　2014/07

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1617. Borderline Resectable (BR) 膵癌に対する治療戦略 : NCCN定義の再考と術前GS療法の意義． Invited

    元井冬彦, 岡田 良, 川口 桂, 青木 豪, 石田晶玄, 薮内伸一, 深瀬耕二, 大塚英郎, 水間正道, 坂田直昭, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川新一, 海野倫明

    癌の臨床　60　(3)　273-280　2014/07

    ISSN： 0021-4949

  1618. Somatostatin analog inhibits the growth of insulinoma cells by p27-mediated G1 cell cycle arrest. Peer-reviewed

    Aoki T, Motoi F, Sakata N, Naitoh T, Katayose Y, Egawa S, Miyazaki J, Unno M

    Pancreas　43　(5)　720-729　2014/07

    DOI： 10.1097/MPA.0000000000000128 　

    ISSN： 0885-3177

  1619. 膵癌根治切除患者における腹腔洗浄細胞診検査の臨床的意義 Peer-reviewed

    里井 壯平, 村上 義昭, 元井 冬彦, 川井 学, 倉田 昌直, 庄 雅之, 松本 逸平, 柳本 泰明, 山本 智久, 上村 健一郎, 海野 倫明, 山上 裕機, 本田 五郎, 木下 正一, 新関 亮, 權 雅憲, Multicenter Study Group of Pancreatobiliary Surgery(MSG-PB)

    膵臓　29　(3)　377-377　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1620. 膵頭部癌に対する門脈合併切除は予後を改善するか Peer-reviewed

    村上 義昭, 里井 壯平, 上村 健一郎, 元井 冬彦, 川井 学, 本田 五郎, 倉田 昌直, 庄 雅之, 赤堀 宇広, 松本 逸平, 浅利 貞毅, 柳本 泰明, 海野 倫明, 山上 裕機, Multicenter Study Group of Pancreatobiliary Surgery(MSG-PBS)

    膵臓　29　(3)　378-378　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1621. 大動脈周囲リンパ節転移陽性膵癌の手術成績 多施設共同研究822例の解析結果 Peer-reviewed

    庄 雅之, 村上 義昭, 元井 冬彦, 里井 壮平, 松本 逸平, 川井 学, 本田 五郎, 上村 健一郎, 柳本 泰明, 倉田 昌直, 後藤 直大, 赤堀 宇広, 海野 倫明, 山上 裕機, 中島 祥介, MSG-PBS

    日本癌治療学会誌　49　(3)　831-831　2014/06

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1622. NF-E2-Related Factor 2 Promotes Compensatory Liver Hypertrophy After Portal Vein Branch Ligation in Mice Peer-reviewed

    Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki Yamamoto

    HEPATOLOGY　59　(6)　2371-2382　2014/06

    DOI： 10.1002/hep.27020 　

    ISSN： 0270-9139

    eISSN： 1527-3350

  1623. Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma Peer-reviewed

    Keiichi Tamai, Mao Nakamura, Masamichi Mizuma, Mai Mochizuki, Misa Yokoyama, Hiroyuki Endo, Kazunori Yamaguchi, Takayuki Nakagawa, Masaaki Shiina, Michiaki Unno, Koji Muramoto, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura, Nobuyuki Tanaka

    CANCER SCIENCE　105　(6)　667-674　2014/06

    DOI： 10.1111/cas.12406 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  1624. 膵癌に対する術前化学療法の有効性評価 Invited

    元井冬彦, 岡田 良, 川口 桂, 益田邦洋, 青木 豪, 藪内伸一, 深瀬耕二, 水間正道, 坂田直昭, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川新一, 海野倫明

    消化器内科　58　(6)　817-823　2014/06

    ISSN： 1884-2895

  1625. Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice Peer-reviewed

    Yoichi Haji, Makiko Suzuki, Kunihiko Moriya, Takanori So, Katsuto Hozumi, Masamichi Mizuma, Michiaki Unno, Naoto Ishii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　447　(2)　346-351　2014/05

    DOI： 10.1016/j.bbrc.2014.04.003 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  1626. 腸閉塞で発症した回腸子宮内膜症の1例 Peer-reviewed

    佐藤 好宏, 渡辺, 和宏, 高橋, 良延, 小針, 正人, 大和田, 康夫, 海野 倫明

    外科　76　(5)　555-558　2014/05

    Publisher:

    ISSN： 0016-593X

  1627. Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". Peer-reviewed

    Nakanuma Y, Sato Y, Ojima H, Kanai Y, Aishima S, Yamamoto M, Ariizumi S, Furukawa T, Hayashi H, Unno M, Ohta T, Hepatolithiasis Subdivision of, Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi

    Int J Clin Exp Pathol　7　(6)　3112-3122　2014/05

  1628. 高濃度Reg蛋白質による膵β細胞死はIL-6/dexamethasoneによるHGF遺伝子の発現誘導によって防止される

    高沢 伸, 中川 圭, 那谷 耕司, 山内 晶世, 広中 安佐子, 太田 浩世, 土田 澄代, 武田 麻衣子, 藤村 貴則, 辻中 大生, 海野 倫明, 岡本 宏

    糖尿病　57　(Suppl.1)　S-263　2014/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  1629. Angiogenesis and vascular maturation in neuroendocrine tumors. Peer-reviewed

    Yazdani S, Kasajima A, Tamaki K, Nakamura Y, Fujishima F, Ohtsuka H, Motoi F, Unno M, Watanabe M, Sato Y, Sasano H

    Human pathology　45　(4)　866-874　2014/04

    DOI： 10.1016/j.humpath.2013.09.024 　

    ISSN： 0046-8177

  1630. Effects of duodeno-jejunal bypass on glucose metabolism in obese rats with type 2 diabetes. Peer-reviewed

    Imoto H, Shibata C, Ikezawa F, Kikuchi D, Someya S, Miura K, Naitoh T, Unno M

    Surgery today　44　(2)　340-348　2014/02

    DOI： 10.1007/s00595-013-0638-x 　

    ISSN： 0941-1291

  1631. Influence of preoperative anti-cancer therapy on resectability and perioperative outcomes in patients with pancreatic cancer: project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Peer-reviewed

    Motoi F, Unno M, Takahashi H, Okada T, Wada K, Sho M, Nagano H, Matsumoto I, Satoi S, Murakami Y, Kishiwada M, Honda G, Kinoshita H, Baba H, Hishinuma S, Kitago M, Tajima H, Shinchi H, Takamori H, Kosuge T, Yamaue H, Takada T

    Journal of hepato-biliary-pancreatic sciences　21　(2)　148-158　2014/02

    DOI： 10.1002/jhbp.15 　

    ISSN： 1868-6974

    More details Close

    BACKGROUND: Little is known about the effects of neoadjuvant therapy on outcomes in patients with pancreatic cancer. This study evaluated the effects of neoadjuvant therapy on resectability and perioperative outcomes. METHODS: A total of 992 patients were enrolled, with 971 deemed eligible. Of these, 582 had resectable tumors and 389 had borderline resectable tumors, and 388 patients received neoadjuvant therapy. Demographic characteristics and peri- and postoperative parameters were assessed by a questionnaire survey. RESULTS: The R0 rate was significantly higher in patients with resectable tumors who received neoadjuvant therapy than in those who underwent surgery first, but no significant difference was noted in patients with borderline resectable tumors. Operation time was significantly longer and blood loss was significantly greater in patients who received neoadjuvant therapy than in those who underwent surgery first, but there were no significant differences in specific complications and mortality rates. The node positivity rate was significantly lower in the neoadjuvant than in the surgery-first group, indicating that the former had significantly lower stage tumors. CONCLUSIONS: Neoadjuvant therapy may not increase the mortality and morbidity rate and may be able to increase the chance for curative resection against resectable tumor.

  1632. Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas Peer-reviewed

    T. Ebata, T. Kosuge, S. Hirano, M. Unno, M. Yamamoto, M. Miyazaki, N. Kokudo, S. Miyagawa, T. Takada, M. Nagino

    British Journal of Surgery　101　(2)　79-88　2014/01

    DOI： 10.1002/bjs.9379 　

    ISSN： 0007-1323 1365-2168

  1633. The effects of endothelial cells- preserving technique on microsurgical vascular reconstruction in biliary tract malignancy: report of twenty cases International-journal

    Miyagi S, Nakanishi W, Kawagishi N, Yoshida H, Unno M, Ohuchi N

    Case Rep Gastroenterol 2014 Jan15; 8(1):18?25. doi: 10.1159/000358192.　8　(1)　18-25　2014

    DOI： 10.1159/000358192 　

    More details Close

    We describe our experience of resectional surgery with microsurgical reconstruction of the hepatic arteries in 20 cases with biliary tract malignancy. Hepatic artery thrombosis (HAT) is a lethal complication; therefore, it is important to perform microsurgical reconstruction safely. Recently, we adopted the back wall support suture technique with double needle sutures that does not require the damaged short arteries to be turned over. In this technique, each stitch is placed from the inner side to the outer side to keep endothelial cells. The purpose of this study was to develop safety methods. From 2003 to 2012, 20 patients with biliary tract malignancy with possible involvement of the hepatic arteries underwent resectional surgery with microvascular reconstruction (cholangiocarcinoma: n = 15; others: n = 5). For this cohort study, patients were divided into two groups: group I (n = 5) included patients who underwent the conventional 'twist technique' and group II (n = 15) included patients who underwent the microsurgical back wall support suture technique with double needle sutures and received gabexate mesilate, a strong serine protease inhibitor (40 mg/kg/day) for 7 days. We investigated HAT using Doppler ultrasonography for 10 days. No postoperative mortality was observed. The incidence of HAT was only one case in group I, and there was no significant difference between the two groups. However, the value of the pulsatile index and acceleration time were significantly improved in group II. In conclusion, the back wall support suture technique with gabexate mesilate administration during microvascular reconstruction was found to be safe. It is important to keep endothelial cells healthy for microvascular reconstruction.

  1634. Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics. Peer-reviewed

    Asano R, Shimomura I, Konno S, Ito A, Masakari Y, Orimo R, Taki S, Arai K, Ogata H, Okada M, Furumoto S, Onitsuka M, Omasa T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I

    mAbs　6　1243-1254　2014

    Publisher: 5

    DOI： 10.4161/mabs.29445 　

    ISSN： 1942-0862

  1635. Role of the intraluminal contents and the continuity of intrinsic neurons in intracolonic capsaicin-induced contraction and defecation in dogs. Peer-reviewed

    Kikuchi D, Shibata C, Imoto H, Someya S, Miyachi T, Miura K, Naitoh T, Unno M

    Surgery today　44　(1)　152-159　2014/01

    DOI： 10.1007/s00595-013-0493-9 　

    ISSN： 0941-1291

  1636. 切除可能膵癌に対する術前治療の有効性． Invited

    元井冬彦, 川口 桂, 益田邦洋, 青木 豪, 工藤克昌, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川新一, 海野倫明

    胆と膵　35　(1)　19-24　2014/01

    ISSN： 0388-9408

  1637. Sudden disappearance of the blood flow in a case of pancreatic acinar cell carcinoma. Peer-reviewed

    Kanno A, Masamune A, Hamada S, Kikuta K, Kume K, Hirota M, Shima K, Okada T, Motoi F, Fujishima F, Ishida K, Unno M, Shimosegawa T

    Internal medicine (Tokyo, Japan)　53　(22)　2589-2593　2014

    DOI： 10.2169/internalmedicine.53.2859 　

    ISSN： 0918-2918

  1638. GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes. Peer-reviewed

    Komatsu H, Tanji E, Sakata N, Aoki T, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M, Furukawa T

    PLoS One　9　(2)　2014

    DOI： 10.1371/journal.pone.0087875 　

  1639. Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation Peer-reviewed

    Kei Nakagawa, Shin Takasawa, Koji Nata, Akiyo Yamauchi, Asako Itaya-Hironaka, Hiroyo Ota, Kiyomi Yoshimoto, Sumiyo Sakuramoto-Tsuchida, Tomoko Miyaoka, Maiko Takeda, Michiaki Unno, Hiroshi Okamoto

    Biochimica et Biophysica Acta - Molecular Cell Research　1833　(12)　2988-2995　2013/12

    DOI： 10.1016/j.bbamcr.2013.08.004 　

    ISSN： 0167-4889 1879-2596

  1640. Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation. Peer-reviewed

    Nakagawa K, Takasawa S, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Yoshimoto K, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, Unno M, Okamoto H

    Biochimica et biophysica acta　1833　(12)　2988-2995　2013/12

    DOI： 10.1016/j.bbamcr.2013.08.004 　

    ISSN： 0006-3002

  1641. 切除企図・切除可能膵癌に対する術前化学療法の有効性

    元井 冬彦, 川口 桂, 青木 豪, 工藤 克昌, 藪内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    癌と化学療法　40　(12)　1632-1636　2013/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1642. Criteria for the glucagon provocative test in the diagnosis of gastrinoma. Peer-reviewed

    Shibata C, Kakyo M, Kinouchi M, Tanaka N, Miura K, Naitoh T, Ogawa H, Motoi F, Egawa S, Ueno T, Naito H, Unno M

    Surgery today　43　(11)　1281-1285　2013/11

    DOI： 10.1007/s00595-012-0334-2 　

    ISSN： 0941-1291

  1643. Dilated papilla with mucin extrusion is a potential predictor of acute pancreatitis associated with intraductal papillary mucinous neoplasms of pancreas. Peer-reviewed

    Hata T, Sakata N, Okada T, Aoki T, Motoi F, Katayose Y, Egawa S, Unno M

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]　13　(6)　615-620　2013/11

    DOI： 10.1016/j.pan.2013.09.003 　

    ISSN： 1424-3903

  1644. [Efficacy of neoadjuvant chemotherapy for resectable pancreatic carcinoma]. Peer-reviewed

    Motoi F, Kawaguchi K, Aoki T, Kudo K, Yabuuchi S, Fukase K, Mizuma M, Sakata N, Otsutomo S, Morikawa T, Hayashi H, Nakagawa K, Okada T, Yoshida H, Naitoh T, Katayose Y, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　40　(12)　1632-1636　2013/11

    ISSN： 0385-0684

  1645. [A case of successful R0 resection after neoadjuvant therapy for locally advanced unresectable pancreatic cancer]. Peer-reviewed

    Aoki S, Mizuma M, Motoi F, Fukase K, Sakata N, Nakagawa K, Okada T, Hayashi H, Morikawa T, Yoshida H, Naitoh T, Katayose Y, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　40　(12)　1868-1871　2013/11

    ISSN： 0385-0684

    More details Close

    Adjuvant surgery for initially unresectable pancreatic cancer with a favorable response to chemotherapy or chemoradiation therapy often contributes to a better prognosis than non-surgical treatment alone. We encountered a sexagenarian woman with cancer of the pancreatic body involving the celiac trunk, common hepatic artery, and gastroduodenal artery, which are normally indicative of an unresectable tumor. After systemic chemotherapy (gemcitabine plus S-1 following chemoradiation therapy [S-1 plus irradiation, total 56 Gy]), the level of carbohydrate antigen 19-9 (CA19-9) decreased to within the normal range and the radiological findings showed a slight regression of the tumor without evidence of metastases. Ten months after the initial treatment, distal pancreatectomy with celiac axis resection was performed. Histopathologically, the tumor was almost replaced by marked fibrosis, including the nerve plexus around the adjacent arteries. Viable cells were observed in a part of the nerve plexus of the common hepatic artery alone. S-1 was administered after the surgery, and the patient has survived without recurrence for 17 months since the initial therapy. Here, we report a case of successful R0 resection after chemoradiation therapy for locally advanced unresectable pancreatic cancer.

  1646. [A case of curatively resected locally advanced pancreatic cancer with combined resection of the portal vein and common hepatic artery after neoadjuvant chemotherapy]. Peer-reviewed

    Kawaguchi K, Motoi F, Yokoyama S, Takemura S, Doi T, Nozawa Y, Fujishima F, Unno M, Kuroda F

    Gan to kagaku ryoho. Cancer & chemotherapy　40　(12)　1875-1877　2013/11

    ISSN： 0385-0684

  1647. [Therapeutic strategy for neuroendocrine tumor of the rectum]. Peer-reviewed

    Ohnuma S, Naitoh T, Haneda S, Kudoh K, Kohyama A, Nagao M, Tanaka N, Sasaki H, Aoki T, Abe T, Musha H, Morikawa T, Yoshida H, Motoi F, Katayose Y, Shibata C, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　40　(12)　2077-2079　2013/11

    ISSN： 0385-0684

  1648. Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma: results from a prospective multi-institutional phase 2 trial. Peer-reviewed

    Motoi F, Ishida K, Fujishima F, Ottomo S, Oikawa M, Okada T, Shimamura H, Takemura S, Ono F, Akada M, Nakagawa K, Katayose Y, Egawa S, Unno M

    Annals of surgical oncology　20　(12)　3794-3801　2013/11

    DOI： 10.1245/s10434-013-3129-9 　

    ISSN： 1068-9265

  1649. Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer. International-journal Peer-reviewed

    Yamamura A, Miura K, Karasawa H, Morishita K, Abe K, Mizuguchi Y, Saiki Y, Fukushige S, Kaneko N, Sase T, Nagase H, Sunamura M, Motoi F, Egawa S, Shibata C, Unno M, Sasaki I, Horii A

    Biochemical and biophysical research communications　441　(1)　102-107　2013/11

    DOI： 10.1016/j.bbrc.2013.10.010 　

    ISSN： 0006-291X

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    Pancreatic cancer is a highly lethal disease with a poor prognosis; the molecular mechanisms of the development of this disease have not yet been fully elucidated. N-myc downstream regulated gene 2 (NDRG2), one of the candidate tumor suppressor genes, is frequently downregulated in pancreatic cancer, but there has been little information regarding its expression in surgically resected pancreatic cancer specimens. We investigated an association between NDRG2 expression and prognosis in 69 primary resected pancreatic cancer specimens by immunohistochemistry and observed a significant association between poor prognosis and NDRG2-negative staining (P=0.038). Treatment with trichostatin A, a histone deacetylase inhibitor, predominantly up-regulated NDRG2 expression in the NDRG2 low-expressing cell lines (PANC-1, PCI-35, PK-45P, and AsPC-1). In contrast, no increased NDRG2 expression was observed after treatment with 5-aza-2' deoxycytidine, a DNA demethylating agent, and no hypermethylation was detected in either pancreatic cancer cell lines or surgically resected specimens by methylation specific PCR. Our present results suggest that (1) NDRG2 is functioning as one of the candidate tumor-suppressor genes in pancreatic carcinogenesis, (2) epigenetic mechanisms such as histone modifications play an essential role in NDRG2 silencing, and (3) the expression of NDRG2 is an independent prognostic factor in pancreatic cancer.

  1650. The best surgical approach for perforated gastric cancer: one-stage vs. two-stage gastrectomy. Peer-reviewed

    Hata,T, Sakata,N, Kudoh,K, Shibata,C, Unno,M

    Gastric.Cancer　17　(3)　578-587　2013/10/12

    Publisher: [Springer Japan]

    DOI： 10.1007/s10120-013-0308-0 　

    ISSN： 1436-3291

  1651. 膵頭十二指腸切除術後の肝切除における術後合併症の検討

    水間 正道, 乙供 茂, 高橋 弥生, 川口 桂, 青木 豪, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　158-158　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1652. 局所進行膵癌に対する集学的治療戦略:GS療法・化学放射線療法後の切除の意義と適応

    元井 冬彦, 川口 桂, 青木 豪, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 三浦 康, 柴田 近, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　164-164　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1653. FDG-PETの膵管内乳頭粘液性腫瘍(IPMN)における診断能と外科切除例における予後予測能について

    岡田 恭穂, 元井 冬彦, 水間 正道, 畠 達夫, 川口 桂, 青木 豪, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 林 洋毅, 中川 圭, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　320-320　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1654. Multiple endocrine neoplasia type 1(MEN-1)に伴うガストリノーマの外科治療

    柴田 近, 森川 孝則, 大塚 英郎, 長尾 宗紀, 田中 直樹, 羽根田 祥, 大沼 忍, 工藤 克昌, 佐々木 宏之, 神山 篤史, 鹿郷 昌之, 小川 仁, 内藤 剛, 三浦 康, 青木 豪, 吉田 寛, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　329-329　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1655. 年齢と併存疾患からみた腹腔鏡補助下胃切除術の周術期成績

    田中 直樹, 鹿郷 昌之, 柴田 近, 工藤 克昌, 神山 篤史, 大沼 忍, 佐々木 宏之, 長尾 宗紀, 森川 孝則, 小川 仁, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　344-344　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1656. 腹腔鏡下に切除した成人横行結腸重複腸管の1例

    小村 俊博, 工藤 克昌, 大沼 忍, 内藤 剛, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　74　(10)　2808-2811　2013/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.74.2808 　

    ISSN： 1345-2843

  1657. Liver、Pancreas、Biliary Tract Cancer 肝・胆・膵癌 肝胆膵癌の新展開 肝外胆管癌に対する術前治療 Invited

    水間正道, 中川 圭, 坂田直昭, 林 洋毅, 岡田恭穂, 森川孝則, 吉田 寛, 元井冬彦, 内藤 剛, 片寄 友, 海野倫明

    癌と化学療法　40　(10)　1311-1313　2013/10

    ISSN： 0385-0684

  1658. 腹壁瘢痕ヘルニア修復術後9年4カ月で発症したメッシュ感染の1例 Peer-reviewed

    畠 達夫, 渡辺和宏, 坂田直昭, 佐藤好宏, 海野倫明

    日臨外会誌　74　(10)　2929-2934　2013/10

    DOI： 10.3919/jjsa.74.2929 　

    ISSN： 1345-2843

  1659. 早期胃癌腹腔鏡下手術中に腸回転異常症が指摘された1例 Peer-reviewed

    伊関雅裕, 安食 隆, 山内淳一郎, 石山秀一, 坂田直昭, 海野倫明

    日臨外会誌　74　(10)　2776-2781　2013/10

    DOI： 10.3919/jjsa.74.2776 　

    ISSN： 1345-2843

  1660. Postoperative cholestasis and cholangitis after total pancreatectomy with biliary reconstruction impair the function of autotransplanted islets. Peer-reviewed

    Hata T, Sakata N, Aoki T, Yoshimatsu G, Tsuchiya H, Hayashi H, Motoi F, Goto M, Katayose Y, Egawa S, Unno M

    Transplantation　96　(5)　e40-3　2013/09

    DOI： 10.1097/TP.0b013e3182a049bb 　

    ISSN： 0041-1337

  1661. Imaging of transplanted islets by positron emission tomography, magnetic resonance imaging, and ultrasonography. Peer-reviewed

    Sakata N, Yoshimatsu G, Tsuchiya H, Aoki T, Mizuma M, Motoi F, Katayose Y, Kodama T, Egawa S, Unno M

    Islets　5　(5)　179-187　2013/09

    DOI： 10.4161/isl.26980 　

    ISSN： 1938-2014

  1662. Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs. Peer-reviewed

    Kikuchi D, Shibata C, Imoto H, Naitoh T, Miura K, Unno M

    The Tohoku journal of experimental medicine　230　(4)　197-204　2013/08

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.230.197 　

    ISSN： 0040-8727

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    Japanese herbal medicine, also known as Kampo, is used for various diseases in Japan. One of those medicines, Dai-Kenchu-To (DKT), is considered clinically effective for adhesive bowel obstruction and chronic constipation. Although scientific evidence of DKT to improve adhesive bowel obstruction was shown in several previous reports, mechanism of DKT to improve constipation remains unknown. Our aim was to study the effect of intragastric DKT on colonic motility and defecation, and the involvement of various receptors in DKT-induced colonic contractions. Five beagle dogs were instructed with serosal strain-gauge force transducers to measure circular muscle activity at the proximal, middle, and distal colon. Dogs are suitable for a present study to administer the drugs repeatedly to the same individual and look at its effect on colonic motility. We studied the effects of DKT (2.5 or 5 g) administered into the stomach on colonic motility. Muscarinic receptor antagonist atropine, nicotinic receptor antagonist hexamthonium, or 5-hydroxytryptamine-3 receptor antagonist ondansetron was injected intravenously 10 min before DKT administration. Capsazepine, an antagonist to transient receptor potential cation channel subfamily V member 1 (TRPV1), was administered into the stomach 5 min before DKT administration. Intragastric DKT (2.5 or 5 g) induced colonic contractions within 10 min after administration but did not induce defecation. Pretreatment with atropine, hexamthonium, ondansetron, or capsazepine inhibited DKT-induced colonic contractions. These results indicate that orally administered DKT stimulates colonic motility via TRPV1, muscarinic, nicotinic, and 5-hydroxytryptamine-3 receptors, thereby providing scientific support for the efficacy of oral DKT in chronic constipation.

  1663. The expression of S100A4 in human pancreatic cancer is associated with invasion. International-journal Peer-reviewed

    Tsukamoto N, Egawa S, Akada M, Abe K, Saiki Y, Kaneko N, Yokoyama S, Shima K, Yamamura A, Motoi F, Abe H, Hayashi H, Ishida K, Moriya T, Tabata T, Kondo E, Kanai N, Gu Z, Sunamura M, Unno M, Horii A

    Pancreas　42　(6)　1027-1033　2013/08

    DOI： 10.1097/MPA.0b013e31828804e7 　

    ISSN： 0885-3177

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    OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies; its poor prognosis is strongly associated with invasion and metastasis. Expression of S100A4 has been reported to correlate with poor prognosis in various cancers. We have investigated the role of S100A4 in pancreatic cancer tumorigenesis and its clinicopathologic significance. METHODS: Protein expression of S100A4 was examined by Western blot in pancreatic cancer cell lines and a human pancreatic ductal epithelium cell line, HPDE-6. Then the expressions of S100A4, TP53, and CD133 were examined immunohistochemically in resected specimens from 83 patients with pancreatic cancer to clarify their clinicopathologic significance. Survival analyses were performed using the Kaplan-Meier method and the Mantel-Cox method. RESULTS: Forty-eight (58%) of 83 patients with pancreatic cancer positively expressed S100A4, and 50 (60%) and 29 (36%) patients positively expressed TP53 and CD133, respectively. S100A4 expression was significantly correlated with perineural invasion (P = 0.029) and invasion pattern (P = 0.001). Neither TP53 nor CD133 expression showed significant correlations with any other parameters. CONCLUSIONS: Our present results suggest that S100A4 plays an important role in the invasiveness, particularly with perineural invasion and invasion pattern, of pancreatic cancer. Development of new strategies targeting S100A4 or its downstream effectors is warranted.

  1664. 当科におけるGIST肝転移症例の検討

    佐藤 好宏, 大塚 英郎, 深瀬 耕二, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　RS-2　2013/07

    Publisher: (一社)日本消化器外科学会

  1665. がん微小環境における新規細胞骨格調節因子GCF2/LRRFIP1の機能解析

    堂地 大輔, 大塚 英郎, 有明 恭平, 深瀬 耕二, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　P-3　2013/07

    Publisher: (一社)日本消化器外科学会

  1666. Duodenal switch for intractable reflux gastroesophagitis after proximal gastrectomy. Peer-reviewed

    Someya S, Shibata C, Tanaka N, Kudoh K, Naitoh T, Miura K, Unno M

    The Tohoku journal of experimental medicine　230　(3)　129-132　2013/07

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.230.129 　

    ISSN： 0040-8727

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    Reflux gastroesophagitis is a common postgastrectomy complication after proximal gastrectomy, and conservative treatments including protease inhibitors and proton pump inhibitors are effective in most patients. Here we report a patient with severe reflux gastroesophagitis after proximal gastrectomy, in whom surgical treatment of duodenal switch was effective. An 80-year-old man complained of intractable heartburn, anorexia, and body weight loss after having undergone proximal gastrectomy, with reconstruction by esophagogastrostomy with valvuloplasty and pyloroplasty, for early gastric cancer 14 months before referral to our department. Oral administration of protease inhibitors and proton pump inhibitors was ineffective. Laboratory evaluation showed poor nutritional status. On endoscopic examination, we noted the redness, bleeding, and multiple erosions in the esophagus and the gastric remnant. He was diagnosed to have severe gastroesophagitis due to reflux of duodenal juice into the gastric remnant and esophagus. We performed duodenal switch to divert duodenal juice from the gastric remnant and esophagus; the duodenum was transected 2 cm distal to the pylorus, the duodenal distal end was closed, and a 50-cm Roux limb from the proximal jejunum was anastomosed to the proximal end of the duodenum. The heartburn disappeared postoperatively, and endoscopic examination revealed marked improvement of the reflux gastroesophagitis. One year postoperatively, the patient is free from symptoms including heartburn. His body weight increased, and laboratory data showed improvement in nutritional status. In conclusion, the duodenal switch may be surgical treatment of choice for intractable reflux gastroesophagitis after proximal gastrectomy.

  1667. Development of Polyvinyl Alcohol Bioartificial Pancreas with Rat Islets and Mesenchymal Stem Cells Peer-reviewed

    G. Yoshimatsu, N. Sakata, H. Tsuchiya, M. Ishida, F. Motoi, S. Egawa, S. Sumi, M. Goto, M. Unno

    TRANSPLANTATION PROCEEDINGS　45　(5)　1875-1880　2013/06

    DOI： 10.1016/j.transproceed.2013.01.043 　

    ISSN： 0041-1345

  1668. 男性に発症し、特異な形態を呈したSolid-pseudo papillary neoplasmの1例

    三浦 晋, 菅野 敦, 中野 絵里子, 滝川 哲也, 有賀 啓之, 濱田 晋, 海野 純, 粂 潔, 菊田 和宏, 廣田 衛久, 正宗 淳, 元井 冬彦, 海野 倫明, 藤島 史喜, 下瀬川 徹

    膵臓　28　(3)　495-495　2013/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1669. Prognosis of autoimmune hepatitis showing acute presentation Peer-reviewed

    Kazuhide Yamamoto, Yasuhiro Miyake, Hiromasa Ohira, Yoshiyuki Suzuki, Mikio Zeniya, Morikazu Onji, Hirohito Tsubouchi, Kaname Yoshizawa, Toshio Morizane, Toshifumi Hibi, Yutaka Aoyagi, Yasuni Nakanuma, Junko Hirohara, Hajime Takikawa, Hiromi Ishibashi, Shinji Shimoda, Shotaro Sakisaka, Makoto Nakamuta, Yasushi Matsuzaki, Toshiji Saibara, Yoshiyuki Ueno, Hiroshi Miyakawa, Norihiro Kokudo, Hiroto Egawa, Yoshihiko Maehara, Satoshi Mochida, Isao Sakaida, Tomoo Fujisawa, Kazuyuki Suzuki, Kazuaki Inoue, Takafumi Ichida, Osamu Yokosuka, Hiroshi Fukui, Hisataka Moriwaki, Mitsuru Mori, Toshiyuki Mori, Masato Nagino, Naohiro Sata, Susumu Tazuma, Takahiro Yasaka, Toshio Tsuyuguchi, Junichi Shoda, Masao Honda, Hiroki Yamaue, Michiaki Unno, Norio Hayashi

    Hepatology Research　43　(6)　630-638　2013/06

    DOI： 10.1111/j.1872-034X.2012.01109.x 　

    ISSN： 1386-6346 1872-034X

  1670. Bach2 maintains T cells in a naive state by suppressing effector memory-related genes. International-journal Peer-reviewed

    Tsukumo S, Unno M, Muto A, Takeuchi A, Kometani K, Kurosaki T, Igarashi K, Saito T

    Proceedings of the National Academy of Sciences of the United States of America　110　(26)　10735-10740　2013/06

    DOI： 10.1073/pnas.1306691110 　

    ISSN： 0027-8424

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    The transcriptional repressor BTB and CNC homology 2 (Bach2) is thought to be mainly expressed in B cells with specific functions such as class switch recombination and somatic hypermutation, but its function in T cells is not known. We found equal Bach2 expression in T cells and analyzed its function using Bach2-deficient (-/-) mice. Although T-cell development was normal, numbers of peripheral naive T cells were decreased, which rapidly produced Th2 cytokines after TCR stimulation. Bach2(-/-) naive T cells highly expressed genes related to effector-memory T cells such as CCR4, ST-2 and Blimp-1. Enhanced expression of these genes induced Bach2(-/-) naive T cells to migrate toward CCR4-ligand and respond to IL33. Forced expression of Bach2 restored the expression of these genes. Using Chromatin Immunoprecipitation (ChIP)-seq analysis, we identified S100 calcium binding protein a, Heme oxigenase 1, and prolyl hydroxylase 3 as Bach2 direct target genes, which are highly expressed in effector-memory T cells. These findings indicate that Bach2 suppresses effector memory-related genes to maintain the naive T-cell state and regulates generation of effector-memory T cells.

  1671. 化学放射線療法(CRT)と化学療法(GS療法)が奏効して切除し得た進行膵体部癌の一例 Peer-reviewed

    高橋 弥生, 森川, 孝則, 元井, 冬彦, 川口, 圭, 薮内, 伸一, 青木, 豪, 坂田, 直昭, 深瀬, 耕二, 水間, 正道, 乙供, 茂, 大塚, 英郎, 中川, 圭 林, 洋毅, 岡田, 恭穂, 吉田, 寛, 内藤, 剛, 片寄, 友, 江川, 新一, 菅野, 敦, 海野 倫明

    膵臓　28　(3)　512-512　2013/06

  1672. 膵全摘後に腸管気腫性嚢胞症を発症した2例 Peer-reviewed

    中川 圭, 元井, 冬彦, 深瀬, 耕二, 水間, 正道, 乙供, 茂, 森川, 孝則, 林, 洋毅, 吉田, 寛, 片寄, 友, 柴田, 近, 江川, 新一, 海野 倫明

    膵臓　28　(3)　512-512　2013/06

  1673. 膵頭十二指腸切除後膵瘻に関する早期発生リスクの検討 Peer-reviewed

    乙供 茂, 元井, 冬彦, 森川, 孝則, 岡田, 恭穂, 中川, 圭 林, 洋毅, 大塚, 英郎, 坂田, 直昭, 水間, 正道, 深瀬, 耕二, 藪内, 伸一, 青木, 豪, 川口, 桂, 吉田, 寛, 内藤, 剛, 片寄, 友, 江川, 新一, 下瀬川, 徹, 海野 倫明

    膵臓　28　(3)　473-473　2013/06

  1674. 通常型膵癌切除例における実5年生存者20例の検討 Peer-reviewed

    吉松 軍平, 元井, 冬彦, 坂田, 直昭, 川口, 桂, 青木, 豪, 藪内, 伸一, 深瀬, 耕二, 水間, 正道, 大塚, 英郎, 中川, 圭, 林, 洋毅, 岡田, 恭穂, 森川, 孝則, 吉田, 寛, 内藤, 剛, 片寄, 友, 江川, 新一, 菅野, 敦, 下瀬川, 徹, 海野 倫明

    膵臓　28　(3)　457-457　2013/06

  1675. IPMN切除後の残膵病変における病理学的検討 Peer-reviewed

    土屋 朗之, 坂田, 直昭, 元井, 冬彦, 川口, 桂, 青木, 豪, 深瀬, 耕二, 薮内, 伸一, 大塚, 英郎, 乙供, 茂, 水間, 正道, 岡田, 恭穂, 中川, 圭, 林, 洋毅, 森川, 孝則, 吉田, 寛, 内藤, 剛, 片寄, 友, 江川, 新一, 下瀬川, 徹, 海野 倫明

    膵臓　28　(3)　456-456　2013/06

  1676. 急性膵炎を発症した膵管内乳頭粘液性腫瘍(IPMN)症例の検討 Peer-reviewed

    畠 達夫, 坂田, 直昭, 岡田, 恭穂, 青木, 豪, 乙供, 茂, 深瀬, 耕二, 大塚, 英郎, 水間, 正道, 中川, 圭, 森川, 孝則, 林, 洋毅, 吉田, 寛, 菅野, 敦, 元井, 冬彦, 内藤, 剛, 片寄, 友, 江川, 新一, 下瀬川, 徹, 海野 倫明

    膵臓　28　(3)　452-452　2013/06

  1677. 慢性膵炎に対するFrey手術症例の検討 Peer-reviewed

    青木 豪, 坂田, 直昭, 川口, 圭, 薮内, 伸一, 深瀬, 耕二, 水間, 正道, 乙供, 茂, 大塚, 英郎, 中川, 圭, 森川, 孝則, 林, 洋毅, 岡田, 恭穂, 吉田, 寛, 元井, 冬彦, 内藤, 剛, 片寄, 友, 江川, 新一, 菅野, 敦, 下瀬川, 徹, 海野 倫明

    膵臓　28　(3)　433-433　2013/06

  1678. 門脈内膵島移植の問題と新たな移植部位の確立に向けて Peer-reviewed

    坂田 直昭, 吉松, 軍平, 土屋, 朗之, 青木, 豪, 川口, 桂, 薮内, 伸一, 深瀬, 耕二, 大塚, 英郎, 乙供, 茂, 水間, 正道, 岡田, 恭穂, 中川, 圭, 林, 洋毅, 森川, 孝則, 吉田, 寛, 元井, 冬彦, 内藤, 剛, 片寄, 友, 江川, 新一, 海野 倫明

    膵臓　28　(3)　397-397　2013/06

  1679. [A case of Peutz-Jeghers syndrome with repeated small intestinal intussusception successfully treated by intraoperative endoscopic polypectomy]. Peer-reviewed

    Miyachi T, Tanaka N, Endo K, Fujishima F, Sasaki H, Nagao M, Morikawa T, Naitoh T, Miura K, Shibata C, Shimosegawa T, Unno M

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology　110　(6)　1014-1021　2013/06

    ISSN： 0446-6586

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    Intestinal polyps are a distinctive feature of Peutz-Jeghers syndrome (PJS). These hamartomas can lead to significant complications such as intussusception or gastrointestinal bleeding which necessitate multiple laparotomies and bowel resections. In an operation for intestinal intussusception, it is preferable to simultaneously resect as many polyps as possible to prevent recurrence of complications caused by intestinal polyps. We report a case of a woman in her twenties with PJS, diagnosed as small intestinal intussusception caused by an intestinal polyp. We performed not only repair of the intussusception but also endoscopic polypectomy without resection of the small intestine. We successfully resected all polyps larger than 10mm from the duodenum to the ascending colon during the operation.

  1680. miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. International-journal Peer-reviewed

    Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Egawa S, Motoi F, Unno M, Shimosegawa T

    Journal of cellular physiology　228　(6)　1255-1263　2013/06

    DOI： 10.1002/jcp.24280 　

    ISSN： 0021-9541

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    Invasive ductal adenocarcinoma (IDA) of the pancreas manifests poor prognosis due to the early invasion and distant metastasis. In contrast, intraductal papillary mucinous adenoma or carcinoma (IPMA or IPMC) reveals better clinical outcomes. Various molecular mechanisms contribute to these differences but entire picture is still unclear. Recent researches emphasized the important role of miRNA in biological processes including cancer invasion and metastasis. We previously described that miR-126 is down-regulated in IDA compared with IPMA or IPMC, and miR-126 regulates the expression of invasion related molecule disintegrin and metalloproteinase domain-containing protein 9 (ADAM9). Assessing the difference of miRNA expression profiles of IDA, IPMA, and IPMC, we newly identified miR-197 as an up-regulated miRNA specifically in IDA. Expression of miR-197 in pancreatic cancer cells resulted in the induction of epithelial-mesenchymal transition (EMT) along with the down-regulation of p120 catenin which is a putative target of miR-197. Direct interaction between miR-197 and p120 catenin mRNA sequence was confirmed by 3'UTR assay, and knockdown of p120 catenin recapitulated EMT induction in pancreatic cancer cells. In situ hybridization of miR-197 and immunohistochemistry of p120 catenin showed mutually exclusive patterns suggesting pivotal role of miR-197 in the regulation of p120 catenin. This miR-197/p120 catenin axis could be a novel therapeutic target.

  1681. 開腹下に内視鏡的ポリープ切除術を施行したPeutz-Jeghers症候群にともなう小腸重積の1例 Peer-reviewed

    宮地 智洋, 田中, 直樹, 遠藤, 克哉, 藤島, 史喜, 佐々木, 宏之, 長尾, 宗紀, 森川, 孝則, 内藤, 剛, 三浦, 康, 柴田, 近, 下瀬川, 徹, 海野 倫明

    日本消化器病学会雑誌　110　(6)　1014-1021　2013/06

    Publisher:

    DOI： 10.11405/nisshoshi.110.1014 　

    ISSN： 0446-6586

    eISSN： 1349-7693

  1682. Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody. Peer-reviewed

    Asano R, Kumagai T, Nagai K, Taki S, Shimomura I, Arai K, Ogata H, Okada M, Hayasaka F, Sanada H, Nakanishi T, Karvonen T, Hayashi H, Katayose Y, Unno M, Kudo T, Umetsu M, Kumagai I

    Protein engineering, design & selection : PEDS　26　(5)　359-367　2013/05

    DOI： 10.1093/protein/gzt009 　

    ISSN： 1741-0126

  1683. Construction of Permanent Ileostomy After Restorative Proctocolectomy for Ulcerative Colitis Peer-reviewed

    Nagao Munenori, Shibata Chikashi, Ogawa Hitoshi, Haneda Sho, Ohnuma Shinobu, Sasaki Hiroyuki, Kohyama Atsushi, Naitoh Takeshi, Miura Koh, Unno Michiaki

    GASTROENTEROLOGY　144　(5)　S1119-S1120　2013/05

    ISSN： 0016-5085

  1684. 縮小と増大をくり返した成人結腸重複症の1例 Peer-reviewed

    畠 達夫, 坂田直昭, 海野倫明

    日臨外会誌　74　(4)　977-981　2013/04

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.74.977 　

    ISSN： 1345-2843

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    A 39-year-old woman who had abdominal pain and was found to have an approximately 8-cm cystic lesion on the mesenteric side of the ascending colon extending to the intra- and extraluminal sides on CT examination at the previous hospital was admitted to our hospital. Barium enema revealed a diverticular structure on the wall of the mesenteric side of the ascending colon. Due to the lack of symptoms and the decrease in the size of the lesion, she underwent follow-up with imaging examinations at our outpatient department. Two years later, she felt abdominal pain again and underwent examination at our hospital. CT examination revealed that the lesion had become larger, extending to the intraluminal side and causing stenosis of the ascending colon. As we could rule out the possibility of a malignant tumor, we performed ileocecal resection for histological diagnosis and relief from symptoms. Histological examination revealed that the cystic lesion was overlaid by the mucosal epithelium, had a smooth muscular layer and had no lumen connecting it to the ascending colon. We finally diagnosed the patient with colonic duplication with a round and non-continuous pattern. The characteristics and impressive imaging findings may be useful for the diagnosis of non-continuous colonic duplication.

  1685. Pancreatic intraepithelial neoplasia-3 with localized acute pancreatitis in the main pancreatic duct. Peer-reviewed

    Okada T, Motoi F, Kanno A, Masamune A, Ishida K, Fujishima F, Rikiyama T, Katayose Y, Egawa S, Shimosegawa T, Unno M

    Clinical journal of gastroenterology　6　(2)　164-168　2013/04

    DOI： 10.1007/s12328-013-0368-z 　

    ISSN： 1865-7257

  1686. Surgical treatment of colorectal cancer associated with ulcerative colitis

    FUNAYAMA Yuji, TAKAHASHI Ken-ichi, IKEZAWA Fumie, OGAWA Hitoshi, WATANABE Kazuhiro, HANEDA Sho, SUZUKI Takayuki, FUKUSHIMA Kohei, UNNO Michiaki, SASAKI Iwao

    Nippon Shokakibyo Gakkai Zasshi　110　(3)　391-395　2013/03/05

    Publisher: The Japanese Society of Gastroenterology

    DOI： 10.11405/nisshoshi.110.391 　

    ISSN： 0446-6586

  1687. 新規RhoA調節蛋白GCF2/LRRFIP1による大腸癌浸潤転移制御の可能性

    大塚 英郎, 有明 恭平, 堂地 大輔, 元井 冬彦, 深瀬 耕二, 青木 豪, 乙供 茂, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 岡田 恭穂, 吉田 寛, 鹿郷 昌之, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　617-617　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1688. Clinical features and treatment outcome of borderline resectable pancreatic head/body cancer: a multi-institutional survey by the Japanese Society of Pancreatic Surgery. Peer-reviewed

    Kato H, Usui M, Isaji S, Nagakawa T, Wada K, Unno M, Nakao A, Miyakawa S, Ohta T

    Journal of hepato-biliary-pancreatic sciences　20　(6)　601-10　2013/03

    DOI： 10.1007/s00534-013-0595-1 　

    ISSN： 1868-6974

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    BACKGROUND: Optimal treatment types and prognosis for patients with borderline resectable pancreatic cancer (BRPC) remain unclear because of the lack of studies involving large series of patients. METHODS: We retrospectively analyzed various prognostic factors for 624 BRPC (pancreatic head/body) patients treated from June 2002 to May 2007, by distributing questionnaires to member institutions of the Japanese Society of Pancreatic Surgery in 2010. BRPC was defined according to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines (2009). RESULTS: Among 624 patients, 539 (86.4 %) underwent curative-intent resection, showing an R0 resection rate of 65.9 %. The 3- and 5-year survival rates were 16.1 and 9.9 % in all patients, 22.8 and 12.5 % in the resected patients, and 4.4 and 0 % (P < 0.0001) in the unresected patients, respectively. The following factors influencing survival in all patients were selected as independent prognostic factors using multivariate analysis: major arterial involvement on imaging study; preoperative treatment; surgical resection; and postoperative chemotherapy. Among the resected cases, multivariate analysis revealed that major arterial involvement and remnant tumor status were independent prognostic factors. CONCLUSION: BRPC included two distinct categories of tumors influencing survival: those with portal vein/superior mesenteric vein invasion alone and those with major arterial invasion, which was the most exacerbating factor in the analysis.

  1689. Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues. International-journal Peer-reviewed

    Takadate T, Onogawa T, Fukuda T, Motoi F, Suzuki T, Fujii K, Kihara M, Mikami S, Bando Y, Maeda S, Ishida K, Minowa T, Hanagata N, Ohtsuka H, Katayose Y, Egawa S, Nishimura T, Unno M

    International journal of cancer　132　(6)　1368-1382　2013/03

    DOI： 10.1002/ijc.27797 　

    ISSN： 0020-7136

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    Pancreatic cancer is among the most lethal malignancies worldwide. We aimed to identify novel prognostic markers by applying mass spectrometry (MS)-based proteomic analysis to formalin-fixed paraffin-embedded (FFPE) tissues. Resectable, node positive pancreatic ductal adenocarcinoma (PDAC) with poor (n = 4) and better (n = 4) outcomes, based on survival duration, with essentially the same clinicopathological backgrounds, and noncancerous pancreatic ducts (n = 5) were analyzed. Cancerous and noncancerous cells collected from FFPE tissue sections by laser microdissection (LMD) were processed for liquid chromatography (LC)-tandem MS (MS/MS). Candidate proteins were identified by semiquantitative comparison and then analyzed quantitatively using selected reaction monitoring (SRM)-based MS. To confirm the associations between candidate proteins and outcomes, we immunohistochemically analyzed a cohort of 87 cases. In result, totally 1,229 proteins were identified and 170 were selected as candidate proteins for SRM-based targeted proteomics. Fourteen proteins overexpressed in cancerous as compared to noncancerous tissue showed different expressions in the poor and better outcome groups. Among these proteins, we found that three novel proteins ECH1, OLFM4 and STML2 were overexpressed in poor group than in better group, and that one known protein GTR1 was expressed reciprocally. Kaplan-Meier analysis showed high expressions of all four proteins to correlate with significantly worse overall survival (p < 0.05). In conclusion, we identified four proteins as candidates of prognostic marker of PDAC. The combination of shotgun proteomics verified by SRM and validated by immunohistochemistry resulted in the prognostic marker discovery that will contribute the understanding of PDAC biology and therapeutic development.

  1690. 残膵全摘10例の検討

    堂地 大輔, 大塚 英郎, 青木 豪, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A244-A244　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1691. 【膵癌外科切除成績の向上を目指した治療戦略】 切除企図膵癌に対する術前化学療法の有効性評価 R0切除とマーカー陰性化による「真の」R0率を指標として Peer-reviewed

    元井 冬彦, 力山, 敏樹, 片寄, 友, 江川, 新一, 海野 倫明

    癌の臨床　59　(1)　61-66　2013/02

  1692. Clinical characteristics of gastric cancer in patients with familial adenomatous polyposis. Peer-reviewed

    Shibata C, Ogawa H, Miura K, Naitoh T, Yamauchi J, Unno M

    The Tohoku journal of experimental medicine　229　(2)　143-146　2013/02

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.229.143 　

    ISSN： 0040-8727

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    Familial adenomatous polyposis is an autosomal dominant hereditary disease leading to the development of numerous colorectal polyps with malignant potential. Extra-colonic neoplasms are observed often in patients with familial adenomatous polyposis, but clinical characteristics of gastric cancer associated with familial adenomatous polyposis are not well understood. We studied the clinical characteristics of five Japanese patients who developed gastric cancer after undergoing colectomy for familial adenomatous polyposis. Gastric cancer was found on gastroduodenal endoscopy performed during postoperative follow-up in all five patients. Mean ages at the time of colectomy and at the time of diagnosis of gastric cancer were 39.2 and 58 years, respectively. Importantly, gastric fundic gland polyps were undetectable in these five patients. The mean duration between colectomy and diagnosis of gastric cancer was more than 20 years in three of five patients (mean: 19 years and 1 month). Cancers were multiple in three of five patients. Two patients developed metachronous gastric cancer in the gastric remnant. All five patients presented with well to moderately differentiated adenocarcinoma; four of the five patients were stage IA. Characteristics of the gastric cancer with familial adenomatous polyposis include a long duration between occurrence of gastric cancer and colectomy, metachronous cancers, multicentric lesions, and a high rate of well to moderately differentiated adenocarcinoma. Long-term and periodic gastroduodenal surveillance endoscopy is recommended for patients with FAP who underwent colectomy.

  1693. Adenocarcinoma associated with perianal fistulas in Crohn's disease. International-journal Peer-reviewed

    Ogawa H, Haneda S, Shibata C, Miura K, Nagao M, Ohnuma S, Kohyama A, Unno M

    Anticancer research　33　(2)　685-689　2013/02

    ISSN： 0250-7005

    eISSN： 1791-7530

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    AIM: The purpose of the present study was to examine the possible relation between anorectal carcinoma and infliximab therapy for Crohn's disease. PATIENTS AND METHODS: This study reviewed the medical records of patients with perianal Crohn's disease, who have required surgical intervention at the Tohoku University Hospital since May 2002, when infliximab was approved as a remedy for Crohn's disease in Japan. RESULTS: Ninety-two patients underwent surgery due to perianal Crohn's disease between May 2002 and December 2011. Four out of 92 patients were diagnosed as having anorectal carcinoma associated with perianal fistula. All four patients had advanced carcinoma, and received infliximab before the diagnosis of cancer was made. Infliximab was administered due to an exacerbated anal lesion in three patients. CONCLUSION: Careful inspection and obtaining of a biopsy sample under anesthesia is recommended for patients with Crohn's disease who have long-standing anal fistulas, especially before infliximab administration due to a possible exacerbation of anal symptoms.

  1694. One of the multifocal intraductal papillary mucinous neoplasms with the clinical characteristics of mucinous cystic neoplasm. Peer-reviewed

    Hata T, Sakata N, Motoi F, Unno M

    BMJ case reports　2013　2013/02

    DOI： 10.1136/bcr-2012-008276 　

  1695. 【通常型膵癌の治療戦略】 切除企図膵癌に対する術前治療戦略の意義 Peer-reviewed

    元井 冬彦, 片寄, 友, 江川, 新一, 海野 倫明

    膵臓　28　(1)　25-33　2013/02

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.28.25 　

    ISSN： 0913-0071

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    Although the standard treatment for resected pancreatic cancer is adjuvant chemotherapy, the strategy cannot be indicated for all cases with planned resection because of delayed recovery and/or residual tumor. A Neoadjuvant strategy (N-group) was compared to the surgery-first approach (S-group) by intention-to-treat anlaysis.<br> Eligibility criteria for adjuvant therapy were defined by: distant lymph node involvement, peritoneal washing cytology, residual tumor, delayed recovery, and serum marker sustained elevation after surgery.<br> Resection rate of N- and S-groups were both more than 80%. The frequency of the case eligible for adjuvant therapy was similar, 47% in S-group and 53% in N-group. The median survival time (MST) of the whole cohort and subgroup receiving adjuvant therapy were 21.2 and 31.6 months in N-group and 17.1 and 21.4 months in S-group, respectively. In N-group, GS-neoadjuvant (NAC-GS) was compared with Gemcitabine-neoadjuvant (NAC-G) treatment. The MST of the whole cohort and subgroup receiving adjuvant therapy in NAC-GS were 25.2 and 35.8 months, respectively, which were both significantly longer than those in NAC-G.<br> These results suggest that neoadjuvant chemotherapy shows a survival benefit without reducing the resection rate.<br>

  1696. Biliary peritonitis due to bile leakage through the gallbladder without perforation, complicated by carcinoma In situ of the gallbladder: Report of a case Peer-reviewed

    Takahiro Kamiga, Kazuhiro Takami, Tomoya Abe, Takeshi Tominaga, Michiaki Unno, Nobuaki Tamahashi

    Japanese Journal of Gastroenterological Surgery　46　(4)　260-267　2013

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.2011.0343 　

    ISSN： 1348-9372 0386-9768

  1697. Connexins regulate cell functions in pancreatic stellate cells International-journal Peer-reviewed

    Masamune, A, Suzuki, N, Kikuta, K.a, Ariga, H.a, Hayashi, S.a, Takikawa, T, Kume, K, Hamada, S, Hirota, M.a, Kanno, A.a, Egawa, S, Unno, M, Shimosegawa, T.a

    Pancreas　42　(2)　308-316　2013

    DOI： 10.1097/MPA.0b013e31825c51d6 　

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    OBJECTIVES: Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis associated with chronic pancreatitis and pancreatic cancer. Connexins (Cxs) allow direct intercellular communications as components of gap junction but also play important roles in the regulation of cell proliferation, cell differentiation, and tissue development. We here examined the expression of Cxs and Cx-mediated regulation of cell functions in PSCs. METHODS: Human PSCs were isolated from patients undergoing operation for chronic pancreatitis or pancreatic cancer. The expression of Cxs was examined by reverse transcription polymerase chain reaction, Western blotting, and immunofluorescent staining. The roles of Cxs in PSC functions were examined by using carbenoxolone, a broad-spectrum Cx inhibitor, and small interfering RNA for Cx43. RESULTS: Human activated PSCs expressed a variety of Cxs including Cx43 both in vitro and in vivo. Carbenoxolone inhibited platelet-derived growth factor-BB-induced proliferation and migration, and type I collagen expression in PSCs. In addition, carbenoxolone inhibited the activation of quiescent PSCs to a myofibroblastlike phenotype. Decreased Cx43 expression by small interfering RNA resulted in decreased proliferation and type I collagen expression. CONCLUSIONS: Pancreatic stellate cells expressed a variety of Cxs. Connexins, especially Cx43, might regulate the cell functions and activation of PSCs.

  1698. 膵癌の治療効果と治療費. Invited

    青木 豪, 坂田直昭, 元井冬彦, 江川新一, 海野倫明

    外科　75　(1)　54-58　2013/01

    Publisher:

    ISSN： 0016-593X

  1699. 慢性膵炎に対するドレナージ手術の適応と実際． Invited

    佐々木宏之, 青木 豪, 坂田直昭, 岡田恭穂, 林 洋毅, 吉田 寛, 元井冬彦, 内藤 剛, 片寄 友, 海野倫明, 江川新一

    胆と膵　34　(臨増特大)　981-984　2013/01

    ISSN： 0388-9408

  1700. Infiltration of CD40-positive tumor-associated macrophages indicates a favorable prognosis in colorectal cancer patients. Peer-reviewed

    Kinouchi M, Miura K, Mizoi T, Ishida K, Fujibuchi W, Sasaki H, Ohnuma S, Saito K, Katayose Y, Naitoh T, Motoi F, Shiiba K, Egawa S, Shibata C, Unno M

    Hepato-gastroenterology　60　(121)　83-88　2013/01

    DOI： 10.5754/hge12372 　

    ISSN： 0172-6390

  1701. Solid pseudopapillary neoplasms of the pancreas: an 18-year experience at a single Japanese Institution. Peer-reviewed

    Morikawa T, Onogawa T, Maeda S, Takadate T, Shirasaki K, Yoshida H, Ishida K, Motoi F, Naitoh T, Rikiyama T, Katayose Y, Egawa S, Unno M

    Surgery today　43　(1)　26-32　2013/01

    DOI： 10.1007/s00595-012-0345-z 　

    ISSN： 0941-1291

  1702. 腹腔鏡下膵体尾部切除術後に遅発性に発症した両側膵性胸水の1例 Peer-reviewed

    森川 孝則, 内藤, 剛, 鹿郷, 昌之, 田中, 直樹, 渡辺, 和宏, 廣田, 衛久, 元井, 冬彦, 三浦, 康, 片寄, 友, 柴田, 近, 江川, 新一, 下瀬川, 徹, 海野 倫明

    膵臓　27　(6)　780-785　2012/12

    DOI： 10.2958/suizo.27.780 　

  1703. GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation. International-journal Peer-reviewed

    Ariake K, Ohtsuka H, Motoi F, Douchi D, Oikawa M, Rikiyama T, Fukase K, Katayose Y, Egawa S, Unno M

    Cancer letters　325　(1)　99-107　2012/12

    DOI： 10.1016/j.canlet.2012.06.012 　

    ISSN： 0304-3835

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    The precise relationship between GCF2 expression and carcinogenesis has not yet been established. To clarify the metastatic potential of GCF2 in colorectal cancer, HT-29 cells stably suppressing GCF2 expression were injected into the spleens of severe combined immunodeficient (SCID) mice. GCF2 suppression reduced the number of metastatic foci in the liver and reduced fibronectin-induced cell adhesion, migration, and invasion. Downstream from the integrin signaling pathways, GCF2 regulates RhoA interaction with the RGS domain of Leukemia associated RhoGEF (LARG). Altogether, our results suggest that GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion.

  1704. 直達手術の遠隔期に生じた門脈血栓症に対して上腸間膜静脈-右卵巣静脈短絡術が奏効した特発性門脈圧亢進症・難治性食道静脈瘤の1例

    堂地 大輔, 鈴木 正徳, 竹内 丙午, 力山 敏樹, 片寄 友, 海野 倫明

    日本門脈圧亢進症学会雑誌　18　(4)　194-199　2012/11

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

    eISSN： 2186-6376

  1705. 術前治療後に腹腔動脈合併膵体尾部切除を行った局所進行膵体部癌の5年生存例 Peer-reviewed

    伊関 雅裕, 元井, 冬彦, 水間, 正道, 林, 洋毅, 中川, 圭, 岡田, 恭穂, 大塚, 英郎, 乙供, 茂, 坂田, 直昭, 深瀬, 耕二, 吉田, 寛, 小野川, 徹, 内藤, 剛, 片寄, 友, 江川, 新一, 海野 倫明

    癌と化学療法　39　(12)　1948-1950　2012/11

  1706. 【内分泌外科の現状と将来】 膵神経内分泌腫瘍の外科

    柴田 近, 江川 新一, 元井 冬彦, 森川 孝則, 内藤 剛, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　113　(6)　502-506　2012/11

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1707. [Surgery for pancreatic neuroendocrine tumors]. Peer-reviewed

    Shibata C, Egawa S, Motoi F, Morikawa T, Naitoh T, Unno M, Sasaki I

    Nihon Geka Gakkai zasshi　113　(6)　502-506　2012/11

    ISSN： 0301-4894

  1708. [A 5-year survival case of locally advanced cancer of the pancreatic body treated by distal pancreatectomy with en bloc celiac axis resection after neoadjuvant chemoradiation therapy]. Peer-reviewed

    Iseki M, Motoi F, Mizuma M, Hayashi H, Nakagawa K, Okada T, Otsuka H, Ottomo S, Sakata N, Fukase K, Yoshida H, Onogawa T, Naito T, Katayose Y, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　39　(12)　1948-1950　2012/11

    ISSN： 0385-0684

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    A 59-year-old man was diagnosed with locally advanced cancer of the pancreatic body, involving the nerve plexus around the celiac axis, the common hepatic artery, and the splenic artery. He was treated with a combination of irradiation (2 Gy/day, total 24 Gy) and 600 mg/m2 of gemcitabine(GEM)biweekly. The tumor size and the involved plexus area were not diminished, but CA19-9 was reduced by half. Distal pancreatectomy with en bloc celiac axis resection(DP-CAR)was performed. The histological findings indicated extensive invasion into the nerve plexus, including that adjacent to the stump of the pancreas, and thus the R classification was R1. After surgery, 1,000 mg/m2 of GEM was administered biweekly. The chemotherapy has been performed for 5 years to prevent local and systemic recurrence. No recurrence has been found 5 years after surgery. Multidisciplinary treatment, combined with neoadjuvant chemoradiation therapy, curative-intent resection, and postoperative chemotherapy is important for effective treatment of locally advanced pancreatic cancer.

  1709. Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. Peer-reviewed

    Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, Takagi K, Onodera Y, Miki Y, Watanabe M, Ishida K, Ohnuma S, Sasaki H, Sato R, Karasawa H, Shibata C, Unno M, Sasaki I, Sasano H

    International journal of cancer　131　(10)　2284-2293　2012/11

    DOI： 10.1002/ijc.27525 　

    ISSN： 0020-7136

  1710. 術前治療とR0を目指した後腹膜一括郭清による進行膵癌に対する治療戦略

    元井 冬彦, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 小野川 徹, 力山 敏樹, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　45　(Suppl.2)　168-168　2012/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1711. 当院における消化管GIST術後再発症例に対する治療成績の検討

    工藤 克昌, 柴田 近, 三浦 康, 安藤 敏典, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 羽根田 祥, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 鈴木 秀幸, 梶原 大輝, 小村 俊博, 染谷 崇徳, 戸嶋 政秀, 松田 泰史, 海野 倫明

    日本消化器外科学会雑誌　45　(Suppl.2)　292-292　2012/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1712. 大建中湯胃内投与の結腸運動亢進効果に関与する受容体の検討

    柴田 近, 菊地 大介, 井本 博文, 染谷 崇徳, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 工藤 克昌, 羽根田 祥, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 長尾 宗紀, 海野 倫明

    日本消化器外科学会雑誌　45　(Suppl.2)　443-443　2012/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1713. 膵癌切除例における術前補助化学療法． Invited

    江川新一, 元井冬彦, 石田晶玄, 深瀬耕二, 水間正道, 坂田直昭, 乙供 茂, 大塚英郎, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 三浦 康, 海野倫明

    癌の臨床　58　(5)　247-254　2012/10

    ISSN： 0021-4949

  1714. PATHOLOGICAL RESPONSE OF SYNCHRONOUS LIVER METASTASES FROM COLORECTAL CANCER TREATED WITH BEVACIZUMAB PLUS MFOLFOX6 IN AN ANALYSIS OF A PHASE II STUDY OF NEOADJUVANT CHEMOTHERAPY Peer-reviewed

    Y. Katayose, J. Yamauchi, M. Oikawa, N. Sakurai, H. Musya, H. Shimamura, K. Miura, K. Nakagawa, S. Egawa, M. Unno

    ANNALS OF ONCOLOGY　23　(9)　211-211　2012/09

    ISSN： 0923-7534

  1715. 【胆膵領域におけるDPCと電子カルテ時代に対応したクリニカルパス】 膵体尾部切除術に対するクリニカルパス Invited

    岡田 恭穂, 江川, 新一, 海野 倫明

    胆と膵　33　(9)　771-776　2012/09

  1716. Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma. Peer-reviewed

    Katayose Y, Nakagawa K, Yamamoto K, Yoshida H, Hayashi H, Mizuma M, Ohtsuka H, Fukase K, Onogawa T, Motoi F, Rikiyama T, Egawa S, Unno M

    Hepato-gastroenterology　59　(118)　1758-1760　2012/09

    DOI： 10.5754/hge11806 　

    ISSN： 0172-6390

  1717. Presented at the 64th Annual Scientific Meeting of the Japanese Association for thoracic surgery: wet-lab training for thoracic surgery at the laboratory animal facilities. Invited Peer-reviewed

    Noda Masafumi, Mizuma Masamichi, Maeda Sumiko, Sakurada Akira, Hoshikawa Yasushi, Endo Chiaki, Okada Yoshinori, Unno Michiaki, Kasai Noriyuki, Kondo Takashi

    Gen Thorac Cardiovasc Surg　in press　2012/08/12

    DOI： 10.1007/s11748-012-0134-z 　

  1718. Keap1 degradation by autophagy for the maintenance of redox homeostasis Peer-reviewed

    Keiko Taguchi, Nanako Fujikawa, Masaaki Komatsu, Tetsuro Ishii, Michiaki Unno, Takaaki Akaike, Hozumi Motohashi, Masayuki Yamamoto

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　109　(34)　13561-13566　2012/08

    DOI： 10.1073/pnas.1121572109 　

    ISSN： 0027-8424

  1719. Aromatase in colon carcinoma. Peer-reviewed

    Sato Ryuichiro, Suzuki Takashi, Katayose Yu, Miura Koh, Shiiba Kenichi, Miki Yasuhiro, Kamogawa Yukiko, Yamamoto Kuniharu, Takayuki, Egawa Shinichi, Unno Michiaki, Sasano Hironobu

    Anticancer Res　32　(8)　3069-3075　2012/08

    ISSN： 0250-7005

  1720. A unique variant of afferent limb syndrome after ileal pouch-anal anastomosis: a case series and review of the literature. Peer-reviewed

    Ogawa H, Haneda S, Watanabe K, Suzuki H, Miura K, Ohnuma S, Sasaki H, Shibata C, Unno M

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　16　(8)　1581-1584　2012/08

    DOI： 10.1007/s11605-012-1872-z 　

    ISSN： 1091-255X

  1721. A Case of Hepatic Portal Venous Gas Due to Accidental Ingestion of Hydrogen Peroxide

    YOSHIMATSU Gumpei, SAKATA Naoaki, YAMANOUCHI Satoshi, AKAISHI Satoshi, FUJITA Motoo, KUSHIMOTO Shigeki, UNNO Michiaki

    Progress in Acute Abdominal Medicine　32　(5)　989-992　2012/07/31

    Publisher: Japanese Society for Abdominal Emergency Medicine

    DOI： 10.11231/jaem.32.989 　

    ISSN： 1340-2242

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    A 75-year-old man was admitted to our hospital due to accidental ingestion of hydrogen peroxide. Although he suffered from repeated vomiting and abdominal fullness, signs of peritonitis were not detected. An abdominal CT examination showed obvious gas images in the gastroepiploic vessels and intrahepatic portal veins. Upper gastrointestinal endoscopy revealed mucosal redness, swelling, and erosion from the lower part of the esophagus to the middle body of the stomach, while there was no evidence of gastrointestinal tract perforation. We treated him non-operatively with a proton pump inhibitor and sodium alginate. On the next day, all of the hepatic portal venous gasses had disappeared on CT and his symptoms had improved. He was discharged on the fifth day after admission. When the hepatic portal gas associated with the ingestion of hydrogen peroxide is not combined with gastrointestinal perforation, conservative therapy can be performed, but it is necessary to observe the case carefully because it could be a preliminary symptom of gas embolism.

  1722. Emergency laparoscopic cholecystectomy for a patient with an implantable left ventricular assist device: report of a case. Peer-reviewed

    Naitoh T, Morikawa T, Sakata N, Unno M, Akiyama M, Saiki Y

    Surg Today　43　(3)　313-316　2012/07/04

    DOI： 10.1007/s00595-012-0241-6 　

  1723. CD133-expressing Cells Have Cancer Stem Cell-like Properties in Cholangiocarcinoma Peer-reviewed

    Y. Kitamura, H. Yoshida, S. Ottomo, M. Mizuma, F. Motoi, T. Rikiyama, Y. Katayose, S. Egawa, M. Unno

    EUROPEAN JOURNAL OF CANCER　48　(5)　S68-S68　2012/07

    ISSN： 0959-8049

  1724. 【最新臨床糖尿病学 下-糖尿病学の最新動向-】 ライフステージ・タイプ別糖尿病の病態と治療 二次性糖尿病 内分泌疾患による糖尿病 グルカゴノーマ (日本臨床)

    柴田近, 三浦康, 内藤剛, 江川新一, 海野倫明

    日本臨床　70　(増刊5 最新臨床糖尿病学(下))　158-160　2012/07

  1725. [Glucagonoma]. Peer-reviewed

    Shibata C, Miura K, Naitoh T, Egawa S, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　70 Suppl 5　158-160　2012/07

    ISSN： 0047-1852

  1726. Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells. Peer-reviewed

    Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Egawa S, Unno M, Terasaki T

    Pharmaceutical research　29　(7)　2006-2016　2012/07

    DOI： 10.1007/s11095-012-0728-2 　

    ISSN： 0724-8741

  1727. Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system Peer-reviewed

    Kentaro Shima, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takaho Okada, Naoaki Sakata, Noriyuki Omura, Yo Kitamura, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Naoto Ishii, Akira Horii, Michiaki Unno

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH　31　2012/06

    DOI： 10.1186/1756-9966-31-55 　

    ISSN： 1756-9966

  1728. 【よくわかるNCD】 NCDへの取り組み 消化器外科 肝胆膵外科

    三浦 文彦, 高田 忠敬, 山本 雅一, 矢永 勝彦, 海野 倫明

    臨床外科　67　(6)　776-778　2012/06

    DOI： 10.11477/mf.1407104106 　

    ISSN： 0386-9857

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    ＜ポイント＞◆肝胆膵外科学会高度技能専門医制度の各種申請の際の高難度肝胆膵外科手術の手術実績は,NCD登録を前提としている.◆2012年1月以降の症例は,NCDの肝胆膵外科詳細項目がすべて入力されていないと,高難度肝胆膵外科手術の手術実績として認められない見込みである.◆NCDでの肝胆膵外科高難度手術の術式選択には注意が必要で,NCDサイト内の[CRF,マニュアル]にある「NCD術式と高難度手術術式の対応表」を適宜参照されたい.(著者抄録)

  1729. 【肝・胆・膵腫瘍の薬物療法-最近の進歩】 膵がん 術前術後補助療法の現状と課題． Invited

    江川新一, 元井冬彦, 石田晶玄, 青木 豪, 深瀬耕二, 水間正道, 坂田直昭, 乙供 茂, 大塚英郎, 森川孝則, 林 洋毅, 中川 圭, 岡田恭穂, 吉田 寛, 内藤 剛, 片寄 友, 海野倫明

    腫瘍内科　9　(6)　718-726　2012/06

    Publisher:

    ISSN： 1881-6568

  1730. Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system. Peer-reviewed

    Shima K, Mizuma M, Hayashi H, Nakagawa K, Okada T, Sakata N, Omura N, Kitamura Y, Motoi F, Rikiyama T, Katayose Y, Egawa S, Ishii N, Horii A, Unno M

    Journal of experimental & clinical cancer research : CR　31　55　2012/06

    DOI： 10.1186/1756-9966-31-55 　

    ISSN： 0392-9078

  1731. Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. International-journal Peer-reviewed

    Takadate T, Onogawa T, Fujii K, Motoi F, Mikami S, Fukuda T, Kihara M, Suzuki T, Takemura T, Minowa T, Hanagata N, Kinoshita K, Morikawa T, Shirasaki K, Rikiyama T, Katayose Y, Egawa S, Nishimura T, Unno M

    Clinical proteomics　9　(1)　8-8　2012/06

    DOI： 10.1186/1559-0275-9-8 　

    ISSN： 1542-6416

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    BACKGROUND: Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic analysis with formalin-fixed paraffin-embedded (FFPE) tissue. RESULTS: The two groups with poor prognosis (n = 4) and with better prognosis (n = 4) had been carefully chosen among 96 resected cases of pancreatic cancer during 1998 to 2007 in Tohoku University Hospital. Although those 2 groups had adjusted background (UICC-Stage IIB, Grade2, R0, gemcitabine adjuvant), there was a significant difference in postoperative mean survival time (poor 21.0 months, better 58.1 months, P = 0.0067). Cancerous epithelial cells collected from FFPE tissue sections by laser micro-dissection (LMD) were processed for liquid chromatography-tandem mass spectrometry (LC-MS/MS). In total, 1099 unique proteins were identified and 6 proteins showed different expressions in the 2 groups by semi-quantitative comparison. Among these 6 proteins, we focused on Nm23/Nucleoside Diphosphate Kinase A (NDPK-A) and immunohistochemically confirmed its expression in the cohort of 96 cases. Kaplan-Meier analysis showed high Nm23/NDPK-A expression to correlate with significantly worse overall survival (P = 0.0103). Moreover, in the multivariate Cox regression model, Nm23/NDPK-A over-expression remained an independent predictor of poor survival with a hazard ratio of 1.97 (95% CI 1.16-3.56, P = 0.0110). CONCLUSIONS: We identified 6 candidate prognostic markers for postoperative pancreatic cancer using FFPE tissues and immunohistochemically demonstrated high Nm23/NDPK-A expression to be a useful prognostic marker for pancreatic cancer.

  1732. 【膵癌update 2012】 治療 最新の膵癌化学療法 Invited

    石田晶玄, 元井冬彦, 坂田直昭, 内藤 剛, 力山敏樹, 片寄 友, 江川新一, 海野倫明

    外科　74　(5)　523-529　2012/05

    Publisher:

    ISSN： 0016-593X

  1733. An analysis of a second-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer. Peer-reviewed

    Katayose Y, Ohtsuka H, Kitamura Y, Masuda K, Nakagawa K, Yamamoto K, Yoshida H, Onogawa T, Motoi F, Naitoh T, Rikiyama T, Egawa S, Unno M

    Hepato-gastroenterology　59　(115)　691-695　2012/05

    DOI： 10.5754/hge11530 　

    ISSN： 0172-6390

  1734. 【学会機関誌創刊に向けて】 膵神経内分泌腫瘍の外科

    江川 新一, 柴田 近, 元井 冬彦, 森川 孝則, 内藤 剛, 海野 倫明, 佐々木 巖

    日本内分泌・甲状腺外科学会雑誌　29　(1)　39-42　2012/04

    Publisher: 日本内分泌外科学会・日本甲状腺外科学会

    DOI： 10.11226/jaesjsts.29.1_39 　

    ISSN： 2186-9545

  1735. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. International-journal Peer-reviewed

    Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, Mano N, Nakano T, Lee Y, Shimizu S, Oba S, Fujiwara S, Shimizu H, Chen N, Nezhad ZK, Jin G, Fukushige S, Sunamura M, Ishida M, Motoi F, Egawa S, Unno M, Horii A

    Biochemical and biophysical research communications　421　(1)　98-104　2012/04

    DOI： 10.1016/j.bbrc.2012.03.122 　

    ISSN： 0006-291X

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    Although gemcitabine is the most effective chemotherapeutic agent against pancreatic cancer, a growing concern is that a substantial number of patients acquire gemcitabine chemoresistance. To elucidate the mechanisms of acquisition of gemcitabine resistance, we developed gemcitabine-resistant cell lines from six human cancer cell lines; three pancreatic, one gastric, one colon, and one bile duct cancer. We first analyzed gemcitabine uptake using three paired parental and gemcitabine resistant pancreatic cancer cell lines (PK-1 and RPK-1, PK-9 and RPK-9, PK-59 and RPK-59) and found that uptake of gemcitabine was rapid. However, no DNA damage was induced in resistant cells. We further examined the microarray-based expression profiles of the cells to identify genes associated with gemcitabine resistance and found a remarkable reduction in the expression of deoxycytidine kinase (DCK). DCK is a key enzyme that activates gemcitabine by phosphorylation. Genetic alterations and expression of DCK were studied in these paired parental and derived gemcitabine-resistant cell lines, and inactivating mutations were found only in gemcitabine-resistant cell lines. Furthermore, siRNA-mediated knockdown of DCK in the parental cell lines yielded gemcitabine resistance, and introduction of DCK into gemcitabine-resistant cell lines invariably restored gemcitabine sensitivities. Mutation analyses were expanded to three other different paired cell lines, DLD-1 and RDLD-1 (colon cancer cell line), MKN-28 and RMKN-28 (gastric cancer cell line), and TFK-1 and RTFK -1 (cholangiocarcinoma cell line). We found inactivating mutations in RDLD-1 and RTFK-1 and decreased expression of DCK in RMKN-28. These results indicate that the inactivation of DCK is one of the crucial mechanisms in acquisition of gemcitabine resistance.

  1736. Distal pancreatectomy (with video). Peer-reviewed

    Egawa S, Okada T, Motoi F, Rikiyama T, Katayose Y, Unno M

    Journal of hepato-biliary-pancreatic sciences　19　(2)　135-140　2012/03

    Publisher: Springer Japan

    DOI： 10.1007/s00534-011-0471-9 　

    ISSN： 1868-6974

  1737. Middle pancreatectomy. Peer-reviewed

    Motoi F, Egawa S, Unno M

    Journal of hepato-biliary-pancreatic sciences　19　(2)　148-151　2012/03

    Publisher: Springer Japan

    DOI： 10.1007/s00534-011-0477-3 　

    ISSN： 1868-6974

  1738. 浸潤性膵管癌切除後6年間無再発であった異時性浸潤性膵管癌の1例

    三浦孝之, 元井冬彦, 深瀬耕二, 大塚英郎, 坂田直昭, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　45　(3)　304-311　2012/03

    Publisher:

    DOI： 10.5833/jjgs.45.304 　

    ISSN： 0386-9768

    eISSN： 1348-9372

  1739. Encapsulated islets transplantation: Past, present and future. Invited Peer-reviewed

    Sakata,N, Sumi,S, Yoshimatsu,G, Goto,M, Egawa,S, Unno,M

    World.J.Gastrointest.Pathophysiol　3　(1)　19-26　2012/02/15

    DOI： 10.4291/wjgp.v3.i1.19 　

  1740. [Efficacy of neoadjuvant chemoradiation therapy for clinical Stage II cholangiocarcinoma as a preoperative diagnosis].

    Kei Nakagawa, Y. Katayose, Michiaki Unno

    Gan to kagaku ryoho. Cancer &amp; chemotherapy　39　(12)　1945-1947　2012

    ISSN： 0385-0684

  1741. Verification of Early Diagnostic Biomarker Candidates for Pancreatic Cancer by FFPE Tissue Proteomics

    Fukuda Tetsuya, Onogawa Tohru, Takadate Tatsuyuki, Fujii Kiyonaga, Mikami Sayaka, Kihara Makoto, Takemura Tarou, Minowa Takashi, Hanagata Nobutaka, Bando Yasuhiko, Nishimura Toshihide, Unno Hiroaki

    Abstracts for Annual Meeting of Japanese Proteomics Society　2012　90-90　2012

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    DOI： 10.14889/jhupo.2012.0.90.0 　

  1742. Adult gastric teratoma associated with gastric cancer in a gastric diverticulum Peer-reviewed

    Takahiro Kamiga, Ryoichi Anzai, Hiroaki Tanno, Takuya Moriya, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　45　(12)　1161-1169　2012

    DOI： 10.5833/jjgs.45.1161 　

    ISSN： 0386-9768 1348-9372

  1743. Sustained elevation of serum tumor markers after resection is an important prognostic factor for pancreatic cancer Peer-reviewed

    Fuyuhiko Motoi, Hiromune Shimamura, Shu-Ichi Ishiyama, Masaya Oikawa, Naoki Sakurai, Youji Anami, Ryuji Nakamura, Tetsuyuki Uchiyama, Yu Katayose, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　45　(7)　697-707　2012

    DOI： 10.5833/jjgs.45.697 　

    ISSN： 0386-9768 1348-9372

  1744. Segmentectomy of the liver. Peer-reviewed

    Yoshida H, Katayose Y, Rikiyama T, Motoi F, Onogawa T, Egawa S, Unno M

    Journal of hepato-biliary-pancreatic sciences　19　(1)　67-71　2012/01

    DOI： 10.1007/s00534-011-0448-8 　

    ISSN： 1868-6974

  1745. [A case of curatively resected locally advanced cancer of the pancreatic body treated by distal pancreatectomy with en bloc celiac axis resection after neoadjuvant chemotherapy]. Peer-reviewed

    Okada T, Sakurai N, Yamamoto K, Motoi F, Kakizaki Y, Tamura G, Unno M, Iizawa H

    Gan to kagaku ryoho. Cancer & chemotherapy　39　(1)　135-137　2012/01

    ISSN： 0385-0684

  1746. [Pancreatic tumor: progress in diagnosis and treatment. Topics: I. Pancreatic carcinoma; 5. Improvements in surgical treatment]. Peer-reviewed

    Egawa S, Motoi F, Unno M

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　101　(1)　37-42　2012/01

    ISSN： 0021-5384

  1747. 術前化学療法施行後、腹腔動脈合併尾側膵切除にてR0手術を施行し得た局所進行膵体部癌の1例 Peer-reviewed

    岡田恭穂, 櫻井直樹, 山本久仁治, 元井冬彦, 柿崎泰明, 田村元, 海野倫明, 飯澤肇

    癌と化学療法　39　(1)　135-137　2012/01

  1748. Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system

    Asano R, Nakayama M, Kawaguchi H, Kubota T, Nakanishi T, Umetsu M, Hayashi H, Katayose Y, Unno M, Kudo T, Kumagai I

    FEBS J.　279　(2)　223-233　2012/01

    DOI： 10.1111/j.1742-4658.2011.08417.x 　

  1749. Clinicopathological Characteristics and Molecular Analyses of Multifocal Intraductal Papillary Mucinous Neoplasms of the Pancreas. Peer-reviewed

    Matthaei H, Norris-Kirby A, Tsiatis AC, Olino K, Hong S, dal Molin M, Goggins MG, Canto M, Horton KM, Jackson KD, Capelli P, Zamboni G, Bortesi L, Furukawa T, Egawa S, Ishida M, Ottomo S, Unno M, Motoi F, Wolfgang CL, Edil BH, Cameron JL, Eshleman JR, Schulick RD, Maitra A, Hruban RH

    Ann Surg　255　(2)　326-333　2012

    DOI： 10.1097/SLA.0b013e3182378a18 　

  1750. Animal Models of Diabetes Mellitus for Islet Transplantation Peer-reviewed

    Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Shinichi Egawa, Michiaki Unno

    EXPERIMENTAL DIABETES RESEARCH　2012　256707-256707　2012

    DOI： 10.1155/2012/256707 　

    ISSN： 1687-5214

    eISSN： 1687-5303

  1751. Intraoperative ultrasound examination is useful for monitoring transplanted islets: A case report Peer-reviewed

    Naoaki Sakata, Masafumi Goto, Yoshimatsu Gumpei, Masamichi Mizuma, Fuyuhiko Motoi, Susumu Satomi, Michiaki Unno

    Islets　4　(5)　339-342　2012

    Publisher: Landes Bioscience

    DOI： 10.4161/isl.22384 　

    ISSN： 1938-2022 1938-2014

  1752. Utility of co-transplanting mesenchymal stem cells in islet transplantation. Invited Peer-reviewed

    Sakata,N, Goto,M, Yoshimatsu,G, Egawa,S, Unno,M

    World J Gastroenterol　17　(47)　5150-5155　2011/12/21

    DOI： 10.3748/wjg.v17.i47.5150 　

  1753. Severe cholestatic liver failure associated with gemcitabine adjuvant monotherapy for pancreatic cancer. Peer-reviewed

    Okada T, Egawa S, Motoi F, Yamamoto K, Ottomo S, Sakata N, Rikiyama T, Katayose Y, Unno M

    Clinical journal of gastroenterology　4　(6)　391-395　2011/12

    DOI： 10.1007/s12328-011-0257-2 　

    ISSN： 1865-7257

  1754. [A case of hypersensitivity reaction to reintroduced-oxaliplatin at the second course of oxaliplatin-based chemotherapy after neoadjuvant chemotherapy for liver metastases from colon cancer]. Peer-reviewed

    Katayose Y, Nakagawa K, Onogawa T, Yoshida H, Motoi F, Naitoh T, Rikiyama T, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　38　(13)　2651-2653　2011/12

    ISSN： 0385-0684

  1755. Oxaliplatin再導入2コース目に即時型アレルギーを呈した大腸癌肝転移再発の1例 Peer-reviewed

    片寄友, 中川圭, 小野川徹, 吉田寛, 元井冬彦, 内藤剛, 力山敏樹, 江川新一, 海野倫明

    癌と化学療法　38　(13)　2651-2653　2011/12

  1756. [A case of distal cholangiocarcinoma with high sensitivity to neoadjuvant chemoradiation therapy]. Peer-reviewed

    Haji Y, Mizuma M, Hayashi H, Nakagawa K, Okada T, Otsuka H, Ottomo S, Sakata N, Fukase K, Yoshida H, Onogawa T, Motoi F, Naito T, Rikiyama T, Katayose Y, Egawa S, Unno M

    Gan to kagaku ryoho. Cancer & chemotherapy　38　(12)　2426-2428　2011/11

    ISSN： 0385-0684

  1757. 術前化学放射線療法に高感受性を示した下部胆管癌の1例

    土師陽一, 水間正道, 林洋毅, 中川圭, 岡田恭穂, 大塚英郎, 乙供茂, 坂田直昭, 深瀬耕二, 吉田寛, 小野川徹, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    癌と化学療法　38　(12)　2426-2428　2011/11

  1758. 【外科医のための最新癌薬物療法】 (I章)臓器別薬物療法 胆道癌 術前療法 Invited

    片寄 友, 力山, 敏樹, 中川, 圭, 江川, 新一, 海野 倫明

    臨床外科　66　(11)　190-195　2011/10

    DOI： 10.11477/mf.1407103804 　

  1759. 膵癌切除後3年後に発生し膵癌肝転移と鑑別が困難であった肝内胆管癌の1例 Peer-reviewed

    小松弘武, 坂田直昭, 元井冬彦, 内藤 剛, 片寄 友, 力山敏樹, 江川新一, 笠島敦子, 石田和之, 海野倫明

    膵臓　26　(5)　190-196　2011/10

    DOI： 10.2958/suizo.26.589 　

    ISSN： 0913-0071

  1760. [Current status and future prospect of pre- and post-operative adjuvant therapy of pancreatic cancer: discussion]. Peer-reviewed

    Unno M, Ueno H, Honda G, Satoi S, Shou M, Tani S, Motoi F

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology　108　(10)　1676-1695　2011/10

    ISSN： 0446-6586

  1761. In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody Peer-reviewed

    Watanabe, Yasuhiro, Asano, Ryutaro, Arai, Kyoko, Shimomura, Ippei, Ogata, Hiromi, Kawaguchi, Hiroko, Hayashi, Hiroki, Ohtsuka, Hideo, Yoshida, Hiroshi, Katayose, Yu, Egawa, Shinichi, Nakanishi, Takeshi, Umetsu, Mitsuo, Yasui, Hiroshi, Ishida, Tadao, Imai, Kohzoh, Kudo, Toshio, Unno, Michiaki, Kumagai, Izumi

    ONCOLOGY REPORTS　26　(4)　949-955　2011/10

    DOI： 10.3892/or.2011.1382 　

    ISSN： 1021-335X

    eISSN： 1791-2431

  1762. Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer: a retrospective study Peer-reviewed

    Shimpei Maeda, Fuyuhiko Motoi, Tohru Onogawa, Takanori Morikawa, Ottomo Shigeru, Naoaki Sakata, Tatsuyuki Takadate, Takeshi Naitoh, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Michiaki Unno

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY　16　(5)　539-545　2011/10

    DOI： 10.1007/s10147-011-0220-8 　

    ISSN： 1341-9625

  1763. GC-binding factor 2 interacts with Dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines Peer-reviewed

    Hideo Ohtsuka, Masaya Oikawa, Kyohei Ariake, Toshiki Rikiyama, Fuyuhiko Motoi, Yu Katayose, Michiaki Unno, Alfred C. Johnson

    INTERNATIONAL JOURNAL OF CANCER　129　(7)　1599-1610　2011/10

    DOI： 10.1002/ijc.25837 　

    ISSN： 0020-7136

  1764. CD133は胆管癌における腫瘍増殖に関係する(CD133 is related to tumorigenicity in cholangiocarcinoma)

    北村 洋, 吉田 寛, 中山 瞬, 高野 成尚, 荒木 孝明, 水間 正道, 乙供 茂, 山本 久仁治, 片寄 友, 江川 新一, 海野 倫明

    日本癌学会総会記事　70回　330-331　2011/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  1765. Neoadjuvant Chemoradiation Therapy With Gemcitabine for Cholangiocarcinoma - Three-years Results After Phase I Study and Interim Analysis of Phase II Study Peer-reviewed

    Y. Katayose, K. Nakagawa, T. Morikawa, H. Yoshida, T. Onogawa, H. Hayashi, F. Motoi, T. Rikiyama, S. Egawa, M. Unno

    EUROPEAN JOURNAL OF CANCER　47　(1)　S448-S449　2011/09

    ISSN： 0959-8049

  1766. Monitoring transplanted islets by high-frequency ultrasound Peer-reviewed

    Naoaki Sakata, Tetsuya Kodama, Rui Chen, Gumpei Yoshimatsu, Masafumi Goto, Shinichi Egawa, Michiaki Unno

    ISLETS　3　(5)　259-266　2011/09

    DOI： 10.4161/isl.3.5.17058 　

    ISSN： 1938-2014

  1767. 直達手術遠隔期に生じた門脈血栓症に対し上腸間膜静脈-右卵巣静脈短絡術が奏効した特発性門脈圧亢進症・難治性食道静脈瘤の一例

    堂地 大輔, 竹内 丙午, 力山 敏樹, 片寄 友, 海野 倫明, 鈴木 正徳

    日本門脈圧亢進症学会雑誌　17　(3)　107-107　2011/08

    Publisher: (一社)日本門脈圧亢進症学会

    ISSN： 1344-8447

    eISSN： 2186-6376

  1768. 【膵神経内分泌腫瘍-Up date 2011】 機能性腫瘍の臨床・画像診断 グルカゴノーマの診断 (肝・胆・膵)

    柴田近, 鹿郷昌之, 田中直樹, 工藤克昌, 三浦康, 内藤剛, 小川仁, 江川新一, 海野倫明, 佐々木巖

    肝・胆・膵　63　(2)　263-266　2011/08

  1769. 胃全摘術を要した急性胃軸捻転症の1例 Peer-reviewed

    深瀬耕二, 伊関雅裕, 森川孝則, 佐藤俊, 富永剛, 海野倫明

    日本消化器外科学会雑誌　44　(8)　963-969　2011/08

  1770. ガストリノーマの臨床診断． Invited

    坂田直昭, 江川新一, 柴田 近, 元井冬彦, 内藤 剛, 海野倫明

    肝胆膵　63　(2)　249-253　2011/08

    ISSN： 0389-4991

  1771. Fulminant type of emphysematous pancreatitis has risk of massive hemorrhage. Peer-reviewed

    Komatsu H, Yoshida H, Hayashi H, Sakata N, Morikawa T, Onogawa T, Motoi F, Rikiyama T, Katayose Y, Egawa S, Hirota M, Shimosegawa T, Unno M

    Clinical journal of gastroenterology　4　(4)　249-254　2011/08

    DOI： 10.1007/s12328-011-0229-6 　

    ISSN： 1865-7257

    More details Close

    Emphysematous pancreatitis (air in the parenchyma) was previously considered an indication for surgery, but some recent studies have reported good clinical outcomes with non-operative management. As a step toward establishing a better treatment strategy, we report a case of fulminant pancreatitis with massive hemorrhage into the emphysematous space. A 75-year-old man was admitted with worsening abdominal pain with obstructive jaundice and renal failure 28 h after the onset. He was diagnosed as having emphysematous pancreatitis with slight pancreatic necrosis. Despite conservative treatment with intensive care, sudden cardiac and respiratory failure occurred, and he died 53 h after onset. The autopsy findings revealed biliary sludge and massive bleeding in the retroperitoneal space around the pancreas, suggesting that temporary obstruction of the bile duct with sludge induced emphysema and the hemorrhage rapidly spread into the broadened emphysematous space. Whereas conservative management has been thought to be appropriate in selected cases of emphysematous pancreatitis, when there is pancreatic emphysema in the early phase, a fulminant course tends to develop. Since there is a risk of massive bleeding into the emphysematous space, endoscopic or invasive drainage performed to collapse the emphysematous space could benefit the outcome.

  1772. Long-Period Pancreatic Stenting for Painful Chronic Calcified Pancreatitis Required Higher Medical Costs and Frequent Hospitalizations Compared With Surgery Peer-reviewed

    Morihisa Hirota, Tohru Asakura, Atsushi Kanno, Kazuhiro Kikuta, Kiyoshi Kume, Shin Hamada, Jun Unno, Hiromichi Ito, Hiroyuki Ariga, Atsushi Masamune, Kennichi Satoh, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Tooru Shimosegawa

    PANCREAS　40　(6)　946-950　2011/08

    DOI： 10.1097/MPA.0b013e31821a9215 　

    ISSN： 0885-3177

    eISSN： 1536-4828

  1773. Intraductal papillary mucininous neoplasm of the bile ducts: multimodality assessment with pathologic correlation Peer-reviewed

    Kentaro Takanami, Takayuki Yamada, Masashi Tsuda, Kei Takase, Kazuyuki Ishida, Yasuhiro Nakamura, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno, Shoki Takahashi

    ABDOMINAL IMAGING　36　(4)　447-456　2011/08

    DOI： 10.1007/s00261-010-9649-x 　

    ISSN： 0942-8925

  1774. Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Peer-reviewed

    Kawai M, Kondo S, Yamaue H, Wada K, Sano K, Motoi F, Unno M, Satoi S, Kwon AH, Hatori T, Yamamoto M, Matsumoto J, Murakami Y, Doi R, Ito M, Miyakawa S, Shinchi H, Natsugoe S, Nakagawara H, Ohta T, Takada T

    Journal of hepato-biliary-pancreatic sciences　18　(4)　601-608　2011/07

    DOI： 10.1007/s00534-011-0373-x 　

    ISSN： 1868-6974

  1775. PV+のBorderline resectable膵癌に対し、術前化学療法が奏功し、PVRなしでR0切除が可能であった1例

    益田邦洋, 内山哲之, 児玉英鎌, 村田幸生, 大石英和, 渡辺みか, 力山敏樹, 元井冬彦, 海野倫明, 伊勢秀雄

    日本消化器外科学会総会　66回　669-669　2011/07

  1776. Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array) Peer-reviewed

    Hideyuki Shimizu, Akira Horii, Makoto Sunamura, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Shinichi Fukushige

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　411　(1)　162-167　2011/07

    DOI： 10.1016/j.bbrc.2011.06.121 　

    ISSN： 0006-291X

  1777. THE STRATEGY OF THE TREATMENT FOR PANCREATIC NEUROENDOCRINE TUMORS WITH LIVER OR LYMPH NODE METASTASES Peer-reviewed

    Nakayama, Shun Ottomo, Shigeru Yoshida, Hiroshi Motoi, Fuyuhiko Rikiyama, Toshiki Katayose, Yu Egawa, Shinichi Unno, Michiaki

    ANNALS OF ONCOLOGY　22　(5)　v68-v68　2011/06

  1778. Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery Peer-reviewed

    Kazuhisa Uchiyama, Masakazu Yamamoto, Hiroki Yamaue, Shun-ichi Ariizumi, Taku Aoki, Norihiro Kokudo, Tomoki Ebata, Masato Nagino, Masayuki Ohtsuka, Masaru Miyazaki, Eiichi Tanaka, Satoshi Kondo, Takahiro Uenishi, Shoji Kubo, Hiroshi Yoshida, Michiaki Unno, Satoru Imura, Mitsuo Shimada, Masaki Ueno, Tadahiro Takada

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　18　(3)　443-452　2011/05

    DOI： 10.1007/s00534-010-0349-2 　

    ISSN： 1868-6974

  1779. Neoadjuvant chemotherapy for pancreatic carcinoma. Invited Peer-reviewed

    Motoi Fuyuhiko, Rikiyama Toshiki, Katayose Yu, Egawa Shinichi, Unno Michiaki

    Nihon Shokakibyo Gakkai Zasshi　108　(10)　1654-1660　2011/04

    Publisher: The Japanese Society of Gastroenterology

    DOI： 10.11405/nisshoshi.108.1654 　

    ISSN： 0446-6586

  1780. 化学療法によって縮小した直腸癌多発肝転移をソナゾイドTM術中USにて描出し肝切除術を行った1例 Peer-reviewed

    乙供茂, 力山敏樹, 江川新一, 片寄友, 元井冬彦, 山本久仁治, 吉田寛, 三浦孝之, 舟山裕士, 海野倫明

    日本消化器外科学会雑誌　44　(4)　490-496　2011/04

  1781. 【膵臓・膵島移植の現況と最新の研究】 MRIを用いた移植膵島の生着評価法 Peer-reviewed

    坂田直昭, 後藤昌史, 江川新一, 海野倫明

    膵臓　26　(2)　190-196　2011/04

    DOI： 10.2958/suizo.26.190 　

  1782. The evaluation of MSX2 mRNA expression level in biliary brush cytological specimens. International-journal Peer-reviewed

    Ito H, Satoh K, Hamada S, Hirota M, Kanno A, Ishida K, Unno J, Masamune A, Katayose Y, Unno M, Shimosegawa T

    Anticancer research　31　(3)　1011-1017　2011/03

    ISSN： 0250-7005

    eISSN： 1791-7530

    More details Close

    BACKGROUND: To distinguish cholangiocarcinoma from inflammatory disease remains difficult when stricture is present in the bile duct. Endoscopic brushing cytology is a convenient method for stricture in the bile duct, however, the diagnostic sensitivity of this method for malignancy is reported to be low (<60%). Msh homeobox 2 is frequently expressed in carcinoma cells of epithelial origin but not in normal tissues. AIM: To assess whether MSX2 expression level in brushing samples allows differentiation of malignant from benign bile duct stricture. PATIENTS AND METHODS: Cytological brushing specimens were obtained from strictures of the bile duct during endoscopic retrograde cholangiopancreaticography (ERCP) in 71 patients. The brushing fluid was subjected to cytological diagnosis and RNA extraction. The expression level of MSX2 was evaluated by one-step real-time RT-PCR. RESULTS: MSX2 expression levels were significantly higher in malignant than in benign bile duct stricture (p=0.004). The sensitivity and specificity for cholangiocarcinoma of cytology and MSX2 expression in strictures of the bile duct were: 55.3% and 100%, and 72.3% and 58.3%, respectively. CONCLUSION: The sensitivity of MSX2 expression level for cholangiocarcinoma was much higher than that of cytology. This suggests that the evaluation of MSX2 level in ERCP brushing samples would be a useful tool to distinguish malignant from benign bile duct stricture.

  1783. Screening of Antibiotics That Interact with Organic Anion-Transporting Polypeptides 1B1 and 1B3 Using Fluorescent Probes Peer-reviewed

    Hiroaki Yamaguchi, Toshiko Takeuchi, Masahiro Okada, Minako Kobayashi, Michiaki Unno, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, Nariyasu Mano

    BIOLOGICAL & PHARMACEUTICAL BULLETIN　34　(3)　389-395　2011/03

    DOI： 10.1248/bpb.34.389 　

    ISSN： 0918-6158

  1784. Computed Tomography Reflected Endocrine Function of the Pancreas Peer-reviewed

    Naoaki Sakata, Shinichi Egawa, Toshiki Rikiyama, Gumpei Yoshimatsu, Kunihiro Masuda, Hideo Ohtsuka, Shigeru Ottomo, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Tohru Onogawa, Kuniharu Yamamoto, Hiroshi Yoshida, Masanori Akada, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno

    JOURNAL OF GASTROINTESTINAL SURGERY　15　(3)　525-532　2011/03

    DOI： 10.1007/s11605-010-1406-5 　

    ISSN： 1091-255X

  1785. 【転移性肝癌 多様化する治療】 大腸癌肝転移の治療 大腸癌肝転移切除例に対する補助化学療法 Invited Peer-reviewed

    山本久仁治, 片寄友, 中川圭, 海野倫明

    臨床消化器内科　26　(4)　421-426　2011/03

  1786. Retrospective Evaluation of the Influence of Postoperative Tumor Marker Status on Survival and Patterns of Recurrence After Surgery for Pancreatic Cancer Based on RECIST Guidelines Peer-reviewed

    Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Shin-ichi Egawa, Michiaki Unno

    ANNALS OF SURGICAL ONCOLOGY　18　(2)　371-379　2011/02

    DOI： 10.1245/s10434-010-1311-x 　

    ISSN： 1068-9265

  1787. 【膵がん・膵内分泌腫瘍の最近の動向】 切除可能および切除境界膵がんに対する術前治療戦略 Invited Peer-reviewed

    元井冬彦, 江川新一, 力山敏樹, 片寄友, 海野倫明

    腫瘍内科　7　(2)　174-180　2011/02

    Publisher:

    ISSN： 1881-6568

  1788. A case of complete transection of the common bile duct due to blunt trauma Peer-reviewed

    Takeaki Sato, Satoshi Akaishi, Michiaki Unno, Iwao Sasaki, Susumu Satomi

    Japanese Journal of Gastroenterological Surgery　44　(7)　848-854　2011

    DOI： 10.5833/jjgs.44.848 　

    ISSN： 0386-9768 1348-9372

  1789. Total gastrectomy for acute organoaxial gastric volvulus Peer-reviewed

    Koji Fukase, Masahiro Iseki, Takanori Morikawa, Syun Sato, Tsuyoshi Tominaga, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　44　(8)　963-969　2011

    DOI： 10.5833/jjgs.44.963 　

    ISSN： 0386-9768 1348-9372

  1790. Minimal multiple liver metastases after chemotherapy from colorectal cancer could be revealed with intra operative ultrasonography using SONAZOID™ Peer-reviewed

    Shigeru Ottomo, Toshiki Rikiyama, Shinichi Egawa, Yu Katayose, Fuyuhiko Motoi, Kuniharu Yamamoto, Hiroshi Yoshida, Takayuki Miura, Yuji Funayama, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　44　(4)　490-496　2011

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.44.490 　

    ISSN： 1348-9372 0386-9768

  1791. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. International-journal Peer-reviewed

    Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, Shin N, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Harada Y, Furukawa T

    Am J Surg Pathol　35　(12)　1812-1817　2011

    DOI： 10.1097/PAS.0b013e31822769a0 　

    More details Close

    Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11 cases of ITPNs and compared these data with those of 50 cases of intraductal papillary mucinous neoplasm (IPMN), another distinct variant of pancreatic intraductal neoplasms. Mutations in PIK3CA were found in 3 of 11 ITPNs but not in IPMNs (P = 0.005; Fisher exact test). In contrast, mutations in KRAS were found in none of the ITPNs but were found in 26 of the 50 IPMNs (P = 0.001; Fisher exact test). PIK3CA mutations were associated with strong expression of phosphorylated AKT (P < 0.001; the Mann-Whitney U test). Moreover, the expression of phosphorylated AKT was apparent in most ITPNs but only in a few IPMNs (P < 0.001; the Mann-Whitney U test). Aberrant expressions of TP53, SMAD4, and CTNNB1 were not statistically different between these neoplasms. Mutations in PIK3CA and the expression of phosphorylated AKT were not associated with age, sex, tissue invasion, and patients' prognosis in ITPNs. These results indicate that activation of the phosphatidylinositol 3-kinase pathway may play a crucial role in ITPNs but not in IPMNs. In contrast, the mutation in KRAS seems to play a major role in IPMNs but not in ITPNs. The activated phosphatidylinositol 3-kinase pathway may be a potential target for molecular diagnosis and therapy of ITPNs.

  1792. Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Peer-reviewed

    Furukawa T, Hatori T, Fujita I, Yamamoto M, Kobayashi M, Ohike N, Morohoshi T, Egawa S, Unno M, Takao S, Osako M, Yonezawa S, Mino-Kenudson M, Lauwers GY, Yamaguchi H, Ban S, Shimizu M

    Gut　60　(4)　509-516　2011

    DOI： 10.1136/gut.2010.210567 　

  1793. Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma Peer-reviewed

    Shin Hamada, Kennichi Satoh, Morihisa Hirota, Atsushi Kanno, Kazuyuki Ishida, Jun Umino, Hiromichi Ito, Kazuhiro Kikuta, Kiyoshi Kume, Atsushi Masamune, Yu Katayose, Michiaki Unno, Tooru Shimosegawa

    CANCER SCIENCE　102　(1)　150-156　2011/01

    DOI： 10.1111/j.1349-7006.2010.01757.x 　

    ISSN： 1347-9032

  1794. Evaluation of MSX2 mRNA in brush cytology specimens distinguished pancreatic carcinoma from chronic pancreatitis Peer-reviewed

    Kennichi Satoh, Shin Hamada, Atsushi Kanno, Kazuyuki Ishida, Hiromichi Ito, Morihisa Hirota, Atsushi Masamune, Shinichi Egawa, Michiaki Unno, Tooru Shimosegawa

    CANCER SCIENCE　102　(1)　157-161　2011/01

    DOI： 10.1111/j.1349-7006.2010.01759.x 　

    ISSN： 1347-9032

  1795. Serous Cystic Neoplasms of the Whole Pancreas in a Patient with von Hippel-Lindau Disease Peer-reviewed

    Atsushi Kanno, Kennichi Satoh, Shin Hamada, Morihisa Hirota, Atsushi Masamune, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Kazuyuki Ishida, Kenji Kimura, Taro Shuin, Tooru Shimosegawa

    INTERNAL MEDICINE　50　(12)　1293-1298　2011

    DOI： 10.2169/internalmedicine.50.4946 　

    ISSN： 0918-2918

  1796. 陽子線治療後にサルベージとして切除した局所進行膵頭部癌の1例 Peer-reviewed

    吉松軍平, 元井冬彦, 坂田直昭, 松田泰史, 水間正道, 乙供茂, 中川圭, 林洋毅, 力山俊樹, 片寄友, 江川新一, 海野倫明

    東北医学雑誌　122　(2)　193-194　2010/12

  1797. 術前に診断し得た下部胆管原発腺内分泌細胞癌の1例 Peer-reviewed

    菅野敦, 佐藤賢一, 廣田衛久, 正宗淳, 高舘達之, 力山敏樹, 海野倫明, 石田和之, 下瀬川徹

    胆道　24　(5)　714-722　2010/12

    Publisher:

    DOI： 10.11210/tando.24.714 　

    ISSN： 0914-0077

    eISSN： 1883-6879

  1798. Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells Peer-reviewed

    Kazuhiro Kikuta, Atsushi Masamune, Takashi Watanabe, Hiroyuki Ariga, Hiromichi Itoh, Shin Hamada, Kennichi Satoh, Shinichi Egawa, Michiaki Unno, Tooru Shimosegawa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　403　(3-4)　380-384　2010/12

    DOI： 10.1016/j.bbrc.2010.11.040 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  1799. [Long-term survival case after liver resection and postoperative hepatic arterial infusion for multiple liver metastases from rectal cancer]. Peer-reviewed

    Kitamura Yo, Katayose Yu, Miura Koh, Yamamoto Kuniharu, Yoshida Hiroshi, Ottomo Shigeru, Motoi Fuyuhiko, Rikiyama Toshiki, Egawa Shinichi, Sasaki Iwao, Unno Michiaki

    Gan To Kagaku Ryoho　37　(12)　2641-2643　2010/11

    ISSN： 0385-0684

  1800. Assessment of Frey procedures: Japanese experience Peer-reviewed

    Shinichi Egawa, Fuyuhiko Motoi, Naoaki Sakata, Yo Kitamura, Kei Nakagawa, Hideo Ohtsuka, Hiroki Hayashi, Takanori Morikawa, Noriyuki Omura, Shigeru Ottomo, Hiroshi Yoshida, Toru Onogawa, Kuniharu Yamamoto, Masanori Akada, Toshiki Rikiyama, Yu Katayose, Seiki Matsuno, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　17　(6)　745-751　2010/11

    DOI： 10.1007/s00534-009-0185-4 　

    ISSN： 1868-6974

  1801. 直腸癌術後に早期多発肝転移を来し手術と肝動注療法を施行し長期生存が得られている1例 Peer-reviewed

    北村洋, 片寄友, 三浦康, 山本久仁治, 吉田寛, 乙供茂, 元井冬彦, 力山敏樹, 江川新一, 佐々木巖, 海野倫明

    癌と化学療法　37　(12)　2641-2643　2010/11

  1802. 内翻したヘルニア嚢が小腸間膜とバンドを形成し内ヘルニアを呈した1例 Peer-reviewed

    三浦孝之, 荒木孝明, 元井冬彦, 田邊淳, 蝦名宣男, 海野倫明

    日本臨床外科学会雑誌　71　(11)　3002-3006　2010/11

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.71.3002 　

    ISSN： 1345-2843

    More details Close

    A 58-year-old man was admitted to hospital due to abdominal pain occurring after the repositioning of an incarcerated left inguinal hernia at the end of August 2009. On the day after admission, abdominal X-rays showed dilatation of the small intestine. Decompression by a long tube relieved the patient's abdominal pain. Tube enterography revealed stenosis of the ileum. Surgery was performed on the tenth hospital day since the long tube was ineffective in dealing with the intestinal obstruction. <BR>During surgery , an inverted left inguinal hernia sac which had adhered to the mesentery proper was found. The ileum was impacted in this space, resulting in an internal hernia. Following reduction of the strangulation, the affected ileum resumed peristalsis ; it was not ischemic. A preperitoneal kugel patch was placed ; intestinal resection was not required. The patient's post-operative course was uneventful. <BR>No other cases of intestinal obstruction due to adhesions of an inverted hernia sac were found in the Japanese literature. Our case is quite rare. However, this condition should be considered in patients who have had an inguinal hernia who then develop abdominal pain.

  1803. 縫合結紮糸変更を軸としたベストプラクティス導入による手術部位感染対策の効果 Peer-reviewed

    内山哲之, 兒玉英謙, 村田幸生, 大石英和, 小田聡, 北山卓, 阿部友哉, 伊勢秀雄, 海野倫明

    日本臨床外科学会雑誌　71　(11)　2773-2780　2010/11

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.71.2773 　

    ISSN： 1345-2843

    More details Close

    [Objective] In this study, the overall effects of changes in prevention strategies for surgical site infection (SSI) including changing the ligation suture were evaluated. [Method] Subjects were consecutive 957 patients who underwent open digestive surgery at our hospital in a 4-year period from October 2004 to September 2008. They were divided into three groups to evaluate the SSI rates, namely 227 patients operated on until September 2005 when silk suture was mainly used (the early group), 485 patients operated on from October 2005 to September 2007 when synthetic absorbable suture was used except for skin closure (the middle group), and 245 patients operated on after October 2007 when the use of silk suture was discontinued completely and when other best practices based on the CDC guideline were introduced (the late group). [Results] The overall SSI rates for the early, middle, and late groups were 27.8%, 17.9%, and 12.2%, respectively, showing significant decreases over the period. The average post-operative length of hospital stay were 30.2 days, 24.0 days, and 20.0 days, respectively, showing decreases. As for the SSI rates by classification, the deep incisional SSI rates were 6.6%, 1.4%, and 2.5%, respectively, showing significant decreases in the middle and late groups compared with the early group. The organ/space SSI rates were 11.9%, 6.4%, and 3.3%, respectively, showing a decreasing tendency even in the late group. [Conclusion] It is concluded that the SSI prevention strategy including the changes in surgical suture allowed the smooth introduction of best practices in the late group. Not only immediate but also overall effects of the ligation suture change have been demonstrated in the late group.

  1804. 浸潤性膵管癌切除6年後、残膵に発生した異時浸潤性膵管癌に対し残膵全摘を施行した1例

    三浦 孝之, 元井 冬彦, 石田 和之, 小松 弘武, 益田 邦洋, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 赤田 昌紀, 力山 敏樹, 片寄 友, 江川 新一, 菅野 敦, 佐藤 賢一, 下瀬川 徹, 海野 倫明

    日本消化器外科学会雑誌　43　(Suppl.2)　375-375　2010/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1805. 消化器外科病棟における栄養サポートチーム(NST)活動

    生澤 史江, 柴田 近, 三浦 康, 内藤 剛, 小川 仁, 鹿郷 昌之, 木内 誠, 安藤 敏典, 矢崎 伸樹, 田中 直樹, 羽根田 祥, 渡辺 和宏, 佐藤 学, 林 洋毅, 海野 倫明, 佐々木 巖

    日本消化器外科学会雑誌　43　(Suppl.2)　238-238　2010/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1806. Successful intervention with a longitudinal pancreaticojejunostomy for chronic pancreatitis due to obstruction of the pancreatogastrostomy after pancreatoduodenectomy Peer-reviewed

    Takayuki Miura, Fuyuhiko Motoi, Kei Ito, Hiromichi Ito, Atsushi Kanno, Kenichi Satoh, Masanori Akada, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Tohru Shimosegawa, Michiaki Unno

    Journal of Japanese Society of Gastroenterology　107　(10)　1669-1675　2010/10

    ISSN： 0446-6586

  1807. 腹腔鏡下修復術を施行したLarrey孔ヘルニアの1例 Peer-reviewed

    阿部友哉, 神賀貴大, 高見一弘, 高野成尚, 富永剛, 海野倫明

    日本臨床外科学会雑誌　71　(10)　2562-2565　2010/10

    DOI： 10.3919/jjsa.71.2562 　

  1808. 膵頭十二指腸切除6年後に発症した膵胃吻合部閉塞による慢性膵炎に膵管空腸側々吻合術が有効であった1例 Peer-reviewed

    三浦孝之, 元井冬彦, 伊藤啓, 伊藤広通, 菅野敦, 佐藤賢一, 赤田昌紀, 力山敏樹, 片寄友, 江川新一, 下瀬川徹, 海野倫明

    日本消化器病学会雑誌　107　(10)　1669-1675　2010/10

    Publisher:

    DOI： 10.11405/nisshoshi.107.1669 　

    ISSN： 0446-6586

    eISSN： 1349-7693

  1809. 【術前・術後に要注意 併存疾患の手術リスクと対策】 基礎疾患併存例の手術 循環器疾患 Invited Peer-reviewed

    林洋毅, 海野倫明

    外科　72　(9)　917-923　2010/09

    Publisher:

    ISSN： 0016-593X

  1810. 肝胆膵手術閉創における真皮縫合とSkin Stapleの創感染率の比較検討． Peer-reviewed

    水間正道, 力山敏樹, 吉田 寛, 小野川徹, 中川 圭, 林 洋毅, 岡田恭穂, 森川孝則, 坂田直昭, 乙供 茂, 大塚英郎, 深瀬耕二, 元井冬彦, 内藤 剛, 片寄 友, 江川新一, 海野倫明

    日外感学誌　8　(6)　687-692　2010/08

    ISSN： 1349-5755

  1811. Blockade of Delta-Like Ligand 4 Signaling Inhibits Both Growth and Angiogenesis of Pancreatic Cancer Peer-reviewed

    Hidekazu Oishi, Makoto Sunamura, Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Toru Furukawa, Nagy A. Habib, Hideo Yagita

    PANCREAS　39　(6)　897-903　2010/08

    DOI： 10.1097/MPA.0b013e3181ce7185 　

    ISSN： 0885-3177

  1812. Expression of MSX2 predicts malignancy of branch duct intraductal papillary mucinous neoplasm of the pancreas Peer-reviewed

    Kennichi Satoh, Shin Hamada, Atsushi Kanno, Morihisa Hirota, Jun Umino, Hiromichi Ito, Atsushi Masamune, Shinichi Egawa, Michiaki Unno, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　45　(7)　763-770　2010/07

    DOI： 10.1007/s00535-010-0200-1 　

    ISSN： 0944-1174

  1813. Major hepatectomy for perihilar cholangiocarcinoma Peer-reviewed

    Michiaki Unno, Yu Katayose, Toshiki Rikiyama, Hiroshi Yoshida, Kuniharu Yamamoto, Takanori Morikawa, Hiroki Hayashi, Fuyuhiko Motoi, Shinichi Egawa

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　17　(4)　463-469　2010/07

    DOI： 10.1007/s00534-009-0206-3 　

    ISSN： 1868-6974

  1814. 【肝門部の解剖を極める 適切な手術とインターベンション治療のために】 肝門部胆管と門脈の解剖 Invited Peer-reviewed

    力山敏樹, 吉田寛, 林洋毅, 元井冬彦, 片寄友, 江川新一, 海野倫明

    胆と膵　31　(7)　703-709　2010/07

  1815. 【必読 炎症性疾患手術】 慢性膵炎に対する外科治療 Frey手術の手技 Invited Peer-reviewed

    江川新一, 坂田直昭, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    手術　64　(8)　1131-1136　2010/07

  1816. 【もう一度学ぶ「ラパコレ」】 「ラパコレ」困難例の予測とインフォームド・コンセント Invited Peer-reviewed

    内藤剛, 海野倫明, 森川孝則

    外科治療　103　(1)　7-11　2010/07

    Publisher:

    ISSN： 0433-2644

  1817. 【進行癌の治療戦略】 膵癌の治療戦略 術前治療とR0切除をめざした後腹膜一括郭清 Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    外科　72　(7)　734-742　2010/07

    Publisher:

    ISSN： 0016-593X

  1818. Highly Enhanced Cytotoxicity of a Dimeric Bispecific Diabody, the hEx3 Tetrabody Peer-reviewed

    Ryutaro Asano, Keiko Ikoma, Yukiko Sone, Hiroko Kawaguchi, Shintaro Taki, Hiroki Hayashi, Takeshi Nakanishi, Mitsuo Umetsu, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    JOURNAL OF BIOLOGICAL CHEMISTRY　285　(27)　20844-20849　2010/07

    DOI： 10.1074/jbc.M110.120444 　

    ISSN： 0021-9258

    eISSN： 1083-351X

  1819. 膵切除術後に発症し、弁置換術施行するも救命しえなかったMRSA感染性心内膜炎の1例 Peer-reviewed

    小松弘武, 吉田寛, 小野川徹, 片寄友, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    日本外科感染症学会雑誌　7　(3)　285-291　2010/06

    Publisher:

    ISSN： 1349-5755

  1820. Target cell-restricted apoptosis induction by 528scFv-TRAIL fusion protein specific for human EGFR and expressed in Escherichia coli Peer-reviewed

    Adel Badran, Ryutaro Asano, Makoto Nakayama, Yasuhiro Watanabe, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Izumi Kumagai

    INTERNATIONAL JOURNAL OF ONCOLOGY　36　(5)　1229-1234　2010/05

    DOI： 10.3892/ijo_00000606 　

    ISSN： 1019-6439

    eISSN： 1791-2423

  1821. 食道癌術後胃管浸潤を来した広義の肝門部胆管癌および下咽頭癌の同時性重複癌の1例 Peer-reviewed

    高舘達之, 山本久仁治, 森川孝則, 小野川徹, 志賀清人, 小林俊光, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    胆道　24　(2)　204-208　2010/05

    DOI： 10.11210/tando.24.204 　

  1822. 【画像による癌深達度診断 外科治療方針決定のために】 膵癌における進行度診断 Invited Peer-reviewed

    乙供茂, 元井冬彦, 江川新一, 海野倫明

    消化器外科　33　(6)　1049-1056　2010/05

  1823. Peutz-Jeghers症候群による小腸癌術後に膵頭部癌を発症し手術を施行した一例 Peer-reviewed

    菊地大介, 蝦名宣男, 田邊淳, 八巻孝之, 原田昭彦, 海野倫明, 江川新一, 元井冬彦, 柴田近, 佐々木巖

    日本消化器病学会雑誌　107　(臨増総会)　A435-A435　2010/03

  1824. 【膵癌治療法の進歩】 Stage IV局所進行膵癌の治療戦略 術前治療(NAC)とR0切除を目的とした後腹膜一括切除(en-bloc dissection:EBD) Invited Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    消化器内科　50　(3)　288-296　2010/03

  1825. 無治療にて2年9ヵ月経過後に治癒切除施行し得た胆管内発育型肝内胆管癌の1例 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 前田晋平, 高舘達之, 吉田寛, 江川新一, 海野倫明

    胆道　24　(1)　105-111　2010/03

    Publisher: Japan Biliary Association

    DOI： 10.11210/tando.24.105 　

    ISSN： 0914-0077

    More details Close

    We experienced a case of intrahepatic cholangiocarcinoma, successfully resected 33 months after first diagnosis. A 72-year-old man, who had been referred to our hospital for the operation of intrahepatic cholangiocarcinoma and declined the treatment 2 years before, was admitted to our hospital for the same diagnosis. CT scan revealed the enlargement of the low density mass at the posterior segment of the bile duct and the atrophy of right lobe due to right portal vein occlusion. Under the diagnosis of intrahepatic cholangiocarcinoma, extended right hepatic sectionectomy and excision of the extrahepatic bile duct were performed. The lesion in the posterior segment was histologically diagnosed as intraductal growth type of intrahepatic cholangiocarcinoma, which is compatible with intraductal papillary neoplasm of the bile duct. The patient is currently alive 3 years after the operation without any signs of recurrence.<br>

  1826. Cytochrome 3A and 2E1 in human liver tissue: Individual variations among normal Japanese subjects Peer-reviewed

    Shuko Hata, Yasuhiro Miki, Fumiyoshi Fujishima, Ryuichiro Sato, Adoru Okaue, Keiko Abe, Kazuyuki Ishida, Jun-ichi Akahira, Michiaki Unno, Hironobu Sasano

    LIFE SCIENCES　86　(11-12)　393-401　2010/03

    DOI： 10.1016/j.lfs.2010.01.011 　

    ISSN： 0024-3205

  1827. Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts Peer-reviewed

    K. Masuda, Y. Ishikawa, I. Onoyama, M. Unno, I. M. de Alboran, K. I. Nakayama, K. Nakayama

    ONCOGENE　29　(12)　1798-1809　2010/03

    DOI： 10.1038/onc.2009.469 　

    ISSN： 0950-9232

  1828. FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts Peer-reviewed

    Kentaro Takanami, Tomomichi Hiraide, Tomohiro Kaneta, Hiroki Hayashi, Michiaki Unno, Fumiyoshi Fujishima, Hiroshi Fukuda, Shogo Yamada, Shoki Takahashi

    CLINICAL NUCLEAR MEDICINE　35　(2)　83-85　2010/02

    DOI： 10.1097/RLU.0b013e3181c7bff0 　

    ISSN： 0363-9762

  1829. 【転移性腫瘍の診断・治療指針】 転移性肝癌の診断と治療 Peer-reviewed

    大村範幸, 山本久仁治, 片寄友, 江川新一, 海野倫明

    癌と化学療法　37　(2)　194-199　2010/02

  1830. 【外科医に必要なPET検査の知識 その有用性と問題点】 胆嚢癌・胆管癌におけるPET検査の意義 Peer-reviewed

    山本久仁治, 海野倫明

    臨床外科　65　(2)　238-242　2010/02

    Publisher:

    DOI： 10.11477/mf.1407102968 　

    ISSN： 0386-9857

  1831. Granular cell tumor of the pancreas: A case report and review of literature Peer-reviewed

    Atsushi Kanno, Kennichi Satoh, Morihisa Hirota, Shin Hamada, Jun Umino, Hiromichi Itoh, Atsushi Masamune, Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Kazuyuki Ishida, Tooru Shimosegawa

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY　2　(2)　121-124　2010/02

    DOI： 10.4251/wjgo.v2.i1.121 　

    ISSN： 1948-5204

  1832. ホルマリン固定パラフィン包埋(FFPE) 組織切片の臨床プロテオーム解析における基礎パラメータの検討 -JHUPO FFPE Clinical Proteome Initiative-

    小野川 徹, 高舘 達之, 三上 紗弥香, 竹村 太郎, 前田 めぐみ, 吉田 寛, 乙供 茂, 前田 晋平, 森川 孝則, 福田 哲也, 板東 泰彦, 箕輪 貴司, 花方 信孝, 西村 俊秀, 海野 倫明

    日本プロテオーム学会大会要旨集　2010　89-89　2010

    Publisher: 日本プロテオーム学会（日本ヒトプロテオーム機構）

    DOI： 10.14889/jhupo.2010.0.89.1 　

  1833. Application of the Fc fusion format to generate tag-free bi-specific diabodies Peer-reviewed

    Ryutaro Asano, Keiko Ikoma, Hiroko Kawaguchi, Yuna Ishiyama, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    FEBS JOURNAL　277　(2)　477-487　2010/01

    DOI： 10.1111/j.1742-4658.2009.07499.x 　

    ISSN： 1742-464X

    eISSN： 1742-4658

  1834. F-18 FDG PET/CT Findings in Two Patients With Hepatic Angiomyolipoma With and Without Intratumoral Hemorrhage Peer-reviewed

    Kentaro Takanami, Tomohiro Kaneta, Shin Hitachi, Takayuki Yamada, Kazuyuki Ishida, Toshiki Rikiyama, Yu Katayose, Michiaki Unno, Shogo Yamada, Shoki Takahashi

    CLINICAL NUCLEAR MEDICINE　35　(1)　18-21　2010/01

    DOI： 10.1097/RLU.0b013e3181c3611f 　

    ISSN： 0363-9762

  1835. The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides Peer-reviewed

    Michiaki Abe, Takafumi Toyohara, Akiko Ishii, Takehiro Suzuki, Naoya Noguchi, Yasutoshi Akiyama, Hiromi O. Shiwaku, Rie Nakagomi-Hagihara, Guodong Zheng, Eisuke Shibata, Tomokazu Souma, Tomohiko Shindo, Hirohito Shima, Yoichi Takeuchi, Eikan Mishima, Masayuki Tanemoto, Tetsuya Terasaki, Tohru Onogawa, Michiaki Unno, Sadayoshi Ito, Shin Takasawa, Takaaki Abe

    DRUG METABOLISM AND PHARMACOKINETICS　25　(3)　274-282　2010

    DOI： 10.2133/dmpk.25.274 　

    ISSN： 1347-4367

  1836. 膵頭十二指腸切除術術後に発症したAeromonas Hydrophila敗血症の1例 Peer-reviewed

    有明恭平, 元井冬彦, 吉田寛, 國島広之, 江川新一, 海野倫明

    日本臨床外科学会雑誌　70　(12)　3517-3522　2009/12

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.70.3517 　

    ISSN： 1345-2843

    More details Close

    The patient was a 77-year-old man with carcinoma of the papilla of vater who underwent pylorus-preserving pancreatoduodenectomy. He developed rapidly progressive respiratory dysfunction 44 hours after the operation. Under assisted ventilation, his arterial blood gas tension continued to deteriorate. Neither anastomotic leakage nor intestinal ischemia was found at the time of emergency exploratory laparotomy 60 hours after the initial operation. Despite intensive medical efforts, he died of multiple organ failure, 83 hours after the initial operation. Aeromonas hydrophila (A. hydrophila) was isolated from blood and ascites. A. hydrophila septicemia is relatively rare. Furthermore, this septicemia is rapidly progressive and is associated with a high mortality rate before the final diagnosis. Taking adequate precautions against A. hydrophila would have an important role in preventing septicemia after surgical operations.

  1837. 【胆道癌治療における癌化学療法の新たな展開】 胆管癌治療に対するNeoadjuvant Chemoradiation Therapyを用いた治療戦略 Peer-reviewed

    片寄友, 森川孝則, 力山敏樹, 江川新一, 海野倫明

    胆と膵　30　(12)　1445-1450　2009/12

  1838. 胆管癌の術前放射線化学療法(NACRAC)による局所制御の可能性 Peer-reviewed

    中川圭, 片寄友, 力山敏樹, 岡上能斗竜, 海野倫明

    癌と化学療法　36　(12)　2009-2011　2009/11

  1839. 手術のtips and pitfalls 肝動脈合併切除・再建を伴う肝門部胆管癌手術 Invited Peer-reviewed

    海野倫明

    日本外科学会雑誌　110　(6)　359-361　2009/11

  1840. 肝内胆管癌に対する放射線療法の治療成績. Invited

    吉田寛 片寄友, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    肝胆膵　57　(1)　143-147　2009/10

  1841. LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells Peer-reviewed

    Jun Unno, Kennichi Satoh, Morihisa Hirota, Atsushi Kanno, Shin Hamada, Hiromichi Ito, Atsushi Masamune, Nobukazu Tsukamoto, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii, Tooru Shimosegawa

    INTERNATIONAL JOURNAL OF ONCOLOGY　35　(4)　813-821　2009/10

    DOI： 10.3892/ijo_00000394 　

    ISSN： 1019-6439

  1842. 類円形を呈した胆管内乳頭状腫瘍の一例 Peer-reviewed

    菅野敦, 佐藤賢一, 廣田衛久, 正宗淳, 片寄友, 海野倫明, 石田和之, 全陽, 下瀬川徹

    胆道　23　(4)　677-683　2009/10

    Publisher:

    DOI： 10.11210/tando.23.677 　

    ISSN： 0914-0077

    eISSN： 1883-6879

  1843. 肝門部胆管癌肝切除120例における術後新鮮凍結血漿投与量の検討 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 林洋毅, 大塚英郎, 元井冬彦, 江川新一, 海野倫明

    胆道　23　(4)　630-639　2009/10

    DOI： 10.11210/tando.23.630 　

  1844. Liver,Pancreas,Biliary Tract Cancer 肝・胆・膵癌 膵癌(浸潤性膵管癌)診療の新たな展開 切除不能・転移性膵癌に対する化学療法 Peer-reviewed

    乙供茂, 江川新一, 海野倫明

    癌と化学療法　36　(10)　1648-1651　2009/10

  1845. The effect of a total colectomy on the motor inhibition of the upper gut induced by intraileal stimuli in conscious dogs Peer-reviewed

    Munenori Nagao, Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Koh Miura, Hitoshi Ogawa, Tatsuya Ueno, Katsuyoshi Kudoh, Michiaki Unno, Iwao Sasaki

    SURGERY TODAY　39　(9)　780-786　2009/09

    DOI： 10.1007/s00595-009-3953-5 　

    ISSN： 0941-1291

  1846. S-1+CDDP併用療法後に切除術を施行した高度進行胃癌症例の検討 Peer-reviewed

    木内誠, 柴田近, 三浦康, 岡部光規, 安藤敏典, 鹿郷昌之, 西條文人, 羽根田祥, 小川仁, 海野倫明, 佐々木巖

    癌と化学療法　36　(9)　1481-1484　2009/09

  1847. 下部胆管に発生した腺内分泌細胞癌の一例

    菅野 敦, 佐藤 賢一, 廣田 衛久, 下瀬川 徹, 力山 敏樹, 海野 倫明, 石田 和之

    胆道　23　(3)　518-518　2009/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  1848. 胆管癌におけるS100P高発現とその意義について(Frequent expression of S100P in the cholangiocarcinoma and its functional role)

    濱田 晋, 佐藤 賢一, 廣田 衛久, 片寄 友, 海野 倫明, 下瀬川 徹

    日本癌学会総会記事　68回　262-262　2009/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1849. Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms Peer-reviewed

    Hiroshi Yamaguchi, Michio Shimizu, Shinichi Ban, Isamu Koyama, Takashi Hatori, Izumi Fujita, Masaka Yamamoto, Shunji Kawamura, Makio Kobayashi, Kazuyuki Ishida, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno, Atsushi Kanno, Kennichi Satoh, Tooru Shimosegawa, Hideki Orikasa, Tomoo Watanabe, Kazuhiko Nishimura, Yoshiro Ebihara, Naoto Koike, Toru Furukawa

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY　33　(8)　1164-1172　2009/08

    DOI： 10.1097/PAS.0b013e3181a162e5 　

    ISSN： 0147-5185

  1850. 【肝胆膵癌に対する補助療法 治療成績の向上を目指して】 胆管癌に対するアジュバントの現状と術前化学放射線療法の可能性 Invited Peer-reviewed

    海野倫明

    臨床外科　64　(7)　919-923　2009/07

    Publisher:

    DOI： 10.11477/mf.1407102619 　

    ISSN： 0386-9857

  1851. 【肝胆膵手術〜教えるポイント・教わるポイント】 教えるポイント・教わるポイント 標準的膵頭十二指腸切除(切除後の再建について) 膵空腸粘膜吻合(no stent法)を中心に Invited Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    手術　63　(7)　1035-1040　2009/06

    Publisher:

    ISSN： 0037-4423

  1852. Overexpression of Adenovirus-mediated p27(kip1) Lacking the Jab1-binding Region Enhances Cytotoxicity and Inhibits Xenografted Human Cholangiocarcinoma Growth Peer-reviewed

    Satoru Shiraso, Yu Katayose, Kuniharu Yamamoto, Masamichi Mizuma, Shinichi Yabuuchi, Akira Oda, Toshiki Rikiyama, Tohru Onogawa, Hiroshi Yoshida, Hiroki Hayashi, Hideo Ohtsuka, Fuyuhiko Motoi, Shinichi Egawa, Junya Kato, Michiaki Unno

    ANTICANCER RESEARCH　29　(6)　2015-2024　2009/06

    ISSN： 0250-7005

  1853. Predominant role of REG R#945; among the REG gene family in the proliferation of human colorectal adenocarcinoma Peer-reviewed

    Yoshikawa Takeo, Ikeda Takayuki, Sakai Kazuko, Noguchi Naoya, Takahashi Iwao, Shervani Nausheen, Uruno Akira, Yamauchi Akiyo, Sakai Eiichi, Onogawa Tohru, Okabe Mitsunori, Ando Toshinori, Kinouchi Makoto, Miura Koh, Unno Michiaki, Emura Tomohiro, Fujiwara Masahiko, Takasawa Shin, Okamoto Hiroshi, Sugawara Akira

    CANCER RESEARCH　69　2009/05/01

    DOI： 10.1369/jhc.2010.956961 　

    ISSN： 0008-5472

  1854. 【新規抗癌剤の導入で膵癌治療はどう変わるか?】 RECIST基準に準じた膵癌切除治療の効果判定 切除完全奏効率からみた術前治療の有効性評価 Invited Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    癌の臨床　55　(3)　191-197　2009/05

  1855. 大腸SM・MP癌における転移・再発の検討と今後への展望 Peer-reviewed

    三浦康, 山村明寛, 唐澤秀明, 金子直征, 岡部光規, 安藤敏典, 小川仁, 柴田近, 木内誠, 佐瀬友彦, 井本博文, 海野倫明, 佐々木巖

    日本大腸肛門病学会雑誌　62　(5)　361-361　2009/05

  1856. Important role of heparan sulfate in postnatal islet growth and insulin secretion Peer-reviewed

    Iwao Takahashi, Naoya Noguchi, Koji Nata, Shuhei Yamada, Tomoyuki Kaneiwa, Shuji Mizumoto, Takayuki Ikeda, Kazushi Sugihara, Masahide Asano, Takeo Yoshikawa, Akiyo Yamauchi, Nausheen Jamal Shervani, Akira Uruno, Ichiro Kato, Michiaki Unno, Kazuyuki Sugahara, Shin Takasawa, Hiroshi Okamoto, Akira Sugawara

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　383　(1)　113-118　2009/05

    DOI： 10.1016/j.bbrc.2009.03.140 　

    ISSN： 0006-291X

  1857. 続発性ヘモクロマトーシスに合併した肝細胞癌にて再々切除術を施行した一症例 Peer-reviewed

    荒木孝明, 片寄友, 中川圭, 山本久二治, 吉田寛, 赤田昌紀, 小野川徹, 林洋毅, 森川孝則, 乙供茂, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    肝臓　50　(Suppl.1)　A363-A363　2009/04

  1858. マウス膵β細胞におけるヘパラン硫酸の発現とインスリン分泌の維持 Peer-reviewed

    野口直哉, 高橋巌, 吉川雄朗, ShervaniNausheen Jamal, 宇留野晃, 海野倫明, 岡本宏, 菅原明

    糖尿病　52　(Suppl.1)　S-216　2009/04

  1859. 術中超音波で確定診断された膵仮性嚢胞内仮性動脈瘤の一切除例 Peer-reviewed

    佐藤学, 江川新一, 福山尚治, 蝦名宣男, 原田昭彦, 對馬清人, 元井冬彦, 海野倫明, 佐々木巖

    膵臓　24　(2)　176-183　2009/04

    DOI： 10.2958/suizo.24.176 　

  1860. Clock Gene Mouse Period2 Overexpression Inhibits Growth of Human Pancreatic Cancer Cells and Has Synergistic Effect with Cisplatin Peer-reviewed

    Akira Oda, Yu Katayose, Shinichi Yabuuchi, Kuniharu Yamamoto, Masamichi Mizuma, Satoru Shirasou, Toru Onogawa, Hideo Ohtsuka, Hiroshi Yoshida, Hiroki Hayashi, Toshiki Rikiyama, Hyunjung Kim, Youngshik Choe, Kyungjin Kim, Hosun Son, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno

    ANTICANCER RESEARCH　29　(4)　1201-1209　2009/04

    ISSN： 0250-7005

  1861. ZD1839 (IRESSA (R)) Stabilizes p27(Kip1) and Enhances Radiosensitivity in Cholangiocarcinoma Cell Lines Peer-reviewed

    Shinichi Yabuuchi, Yu Katayose, Akira Oda, Masamichi Mizuma, Satoru Shirasou, Tsuyoshi Sasaki, Kunhiharu Yamamoto, Masaya Oikawa, Toshiki Rikiyama, Tohru Onogawa, Hiroshi Yoshida, Hideo Ohtuska, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno

    ANTICANCER RESEARCH　29　(4)　1169-1180　2009/04

    ISSN： 0250-7005

  1862. FDG-PETによる胆道癌の浸潤能評価 Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 吉田寛, 林洋毅, 森川孝則, 乙供茂, 大塚英郎, 佐藤龍一郎, 益田邦洋, 北村洋, 荒木孝明, 江川新一, 海野倫明

    日本消化器病学会雑誌　106　(臨増総会)　A331-A331　2009/03

  1863. 大建中湯の胃・結腸内投与による結腸運動亢進作用と各種拮抗剤の影響の検討 Peer-reviewed

    菊地大介, 柴田近, 福島浩平, 三浦康, 小川仁, 鹿郷昌之, 木内誠, 西條文人, 林啓一, 佐藤学, 生澤史江, 井本博文, 海野倫明, 佐々木巖

    日本消化器病学会雑誌　106　(臨増総会)　A312-A312　2009/03

  1864. 胆管癌に対する術前化学放射線療法施行例30例の検討 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 阿部永, 林洋毅, 大塚英郎, 乙供茂, 岡上能斗竜, 前田晋平, 高舘達之, 江川新一, 海野倫明

    日本消化器病学会雑誌　106　(臨増総会)　A301-A301　2009/03

  1865. 胆道癌の進展度診断と治療戦略 MDCTによる胆管癌の長軸進展度診断と治療方針 Peer-reviewed

    力山敏樹, 岡上能斗竜, 海野倫明

    日本消化器病学会雑誌　106　(臨増総会)　A90-A90　2009/03

  1866. 膵悪性疾患に対する治療成績の進歩 Stage IV局所進行膵癌に対する治療戦略:術前治療(NAC)と剥離面陰性化を目的とした後腹膜一括切除(en bloc dissection:EBD)の有効性の検証 Peer-reviewed

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　106　(臨増総会)　A56-A56　2009/03

  1867. 肝門部に限局した病変を有し肝門部胆管癌との鑑別に苦慮したIgG4関連硬化性胆管炎の1例 Invited Peer-reviewed

    海野倫明, 力山敏樹, 岡上能斗竜, 片寄友

    胆道　23　(1)　119-123　2009/03

    Publisher: Japan Biliary Association

    DOI： 10.11210/tando.23.119 　

    ISSN： 0914-0077

  1868. Matrix metalloproteinase-9 derived from polymorphonuclear neutrophils increases gut barrier dysfunction and bacterial translocation in rat severe acute pancreatitis Peer-reviewed

    Yukio Mikami, Ernst V. Dobschuetz, Olaf Sommer, Ulrich Wellner, Michiaki Unno, Ulrich Hopt, Tobias Keck

    SURGERY　145　(2)　147-156　2009/02

    DOI： 10.1016/j.surg.2008.08.036 　

    ISSN： 0039-6060

  1869. 膵管癌におけるS100A4の免疫組織化学的発現解析並びに臨床病理学的検討 Peer-reviewed

    塚本信和, 阿部永, 林洋毅, 阿部佳子, 江川新一, 海野倫明, 堀井明

    日本外科学会雑誌　110　(臨増2)　757-757　2009/02

  1870. 幽門輪温存膵頭十二指腸切除術と亜全胃温存膵頭十二指腸切除術の周術期比較 Peer-reviewed

    北村洋, 江川新一, 山本久仁治, 吉田寛, 乙供茂, 赤田昌紀, 阿部永, 森川孝則, 林洋毅, 大塚英郎, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    日本外科学会雑誌　110　(臨増2)　765-765　2009/02

  1871. 結腸内カプサイシン投与の結腸運動亢進・排便誘発効果とその作用機序 Peer-reviewed

    林啓一, 柴田近, 三浦康, 小川仁, 鹿郷昌之, 岡部光規, 木内誠, 佐藤学, 菊地大介, 海野倫明, 佐々木巖

    日本外科学会雑誌　110　(臨増2)　708-708　2009/02

  1872. fCurCに終わった胆嚢癌切除症例からみた予後と手術適応 Peer-reviewed

    林洋毅, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　640-640　2009/02

  1873. 局所進行膵体部癌に対する全胃温存腹腔動脈合併膵体尾部切除術の検討 Peer-reviewed

    有明恭平, 元井冬彦, 大塚英郎, 横山智, 川口桂, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　634-634　2009/02

  1874. flow cytometryを用いた大腸癌組織における腫瘍関連マクロファージの検討 Peer-reviewed

    木内誠, 三浦康, 岡部光規, 安藤敏典, 柴田近, 鹿郷昌之, 長尾宗記, 西條文人, 羽根田翔, 小川仁, 海野倫明, 佐々木巖

    日本外科学会雑誌　110　(臨増2)　589-589　2009/02

  1875. 大腸SM・MP癌における転移・再発例の検討と今後への展望 Peer-reviewed

    山村明寛, 三浦康, 唐澤秀明, 金子直征, 岡部光則, 安藤敏典, 小川仁, 柴田近, 木内誠, 佐瀬友彦, 福島浩平, 海野倫明, 佐々木巖

    日本外科学会雑誌　110　(臨増2)　580-580　2009/02

  1876. 長期生存膵癌の条件と遺伝子発現 Peer-reviewed

    赤田昌紀, 江川新一, 元井冬彦, 乙供茂, 阿部永, 吉田寛, 林洋毅, 森川孝則, 大塚英郎, 山本久仁治, 力山敏樹, 片寄友, 海野倫明

    日本外科学会雑誌　110　(臨増2)　505-505　2009/02

  1877. 先天性胆道拡張症分流手術後長期合併症の検討 Peer-reviewed

    大塚英郎, 元井冬彦, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　496-496　2009/02

  1878. ステロイドサルファターゼとエストロゲンスルフォトランスフェラーゼは大腸癌腫瘍内エストロゲン濃度を制御し、また、予後規定因子となる Peer-reviewed

    佐藤龍一郎, 鈴木貴, 山本久仁治, 三浦康, 椎葉健一, 立野紘雄, 三木康宏, 井伊貴幸, 赤平純一, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 笹野公伸, 海野倫明

    日本外科学会雑誌　110　(臨増2)　448-448　2009/02

  1879. 先天性胆道拡張症分流手術後の遺残膵内胆管癌 自験例3例と本邦報告例の検討 Peer-reviewed

    前田晋平, 片寄友, 森川孝則, 岡上能斗竜, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 林洋毅, 阿部永, 乙供茂, 大塚英郎, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　236-236　2009/02

  1880. 膵癌細胞における薬物輸送担体タンパク群及び関連代謝酵素の網羅的同時絶対定量解析に基づくGEM感受性・耐性規定因子の同定 Peer-reviewed

    川口桂, 元井冬彦, 大峰健, 大槻純男, 大塚英郎, 力山敏樹, 片寄友, 江川新一, 寺崎哲也, 海野倫明

    日本外科学会雑誌　110　(臨増2)　225-225　2009/02

  1881. RAB27B遺伝子は膵癌における候補癌抑制遺伝子である Peer-reviewed

    横山智, 元井冬彦, 大塚英郎, 川口桂, 有明恭平, 江川新一, 堀井明, 海野倫明

    日本外科学会雑誌　110　(臨増2)　224-224　2009/02

  1882. GEM、TS1時代の膵癌外科治療 膵癌に対するGemcitabine術前化学療法の有用性 Peer-reviewed

    乙供茂, 元井冬彦, 片寄友, 力山敏樹, 赤田昌紀, 山本久仁治, 吉田寛, 森川孝則, 阿部永, 林洋毅, 大塚英郎, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　172-172　2009/02

  1883. 膵臓外科の諸問題に対する対策 Stage IV進行膵頭部癌に対する、後腹膜・大動脈周囲リンパ節・神経叢一括郭清(PD-En bloc) Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　129-129　2009/02

  1884. 胆道癌における進展度診断の新展開 胆道癌における進展度診断の体系化と新展開 Invited Peer-reviewed

    海野倫明

    日本外科学会雑誌　110　(臨増2)　88-88　2009/02

  1885. 胆道癌のneoadjuvant therapy Invited Peer-reviewed

    海野倫明, 片寄友

    コンセンサス癌治療　8　(1)　46-47　2009/02

  1886. Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma: Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors Peer-reviewed

    Ryuichiro Sato, Takashi Suzuki, Yu Katayose, Koh Miura, Kenichi Shiiba, Hiroo Tateno, Yasuhiro Miki, Junichi Akahira, Yukiko Kamogawa, Shuji Nagasaki, Kuniharu Yamamoto, Takayuki Ii, Shinichi Egawa, Dean B. Evans, Michiaki Unno, Hironobu Sasano

    CANCER RESEARCH　69　(3)　914-922　2009/02

    DOI： 10.1158/0008-5472.CAN-08-0906 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1887. Thiazolidinediones inhibit REG I alpha gene transcription in gastrointestinal cancer cells Peer-reviewed

    Akiyo Yamauchi, Iwao Takahashi, Shin Takasawa, Koji Nata, Naoya Noguchi, Takayuki Ikeda, Takeo Yoshikawa, Nausheen J. Shervani, Iwao Suzuki, Akira Uruno, Michiaki Unno, Hiroshi Okamoto, Akira Sugawara

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　379　(3)　743-748　2009/02

    DOI： 10.1016/j.bbrc.2008.12.113 　

    ISSN： 0006-291X

  1888. How much of the pancreatic head should we resect in Frey&apos;s procedure? Peer-reviewed

    Naoaki Sakata, Shinichi Egawa, Fuyuhiko Motoi, Masafumi Goto, Seiki Matsuno, Yu Katayose, Michiaki Unno

    SURGERY TODAY　39　(2)　120-127　2009/02

    DOI： 10.1007/s00595-008-3816-5 　

    ISSN： 0941-1291

  1889. Correct Diagnosis of Vascular Encasement and Longitudinal Extension of Hilar Cholangiocarcinoma by Four-Channel Multidetector-Row Computed Tomography Peer-reviewed

    Tadayuki Okumoto, Akihiro Sato, Takayuki Yamada, Kei Takase, Toshio Matsuhashi, Masashi Tsuda, Kazumasa Seiji, Tadashi Ishibashi, Shuichi Higano, Yu Katayose, Michiaki Unno, Shoki Takahashi

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　217　(1)　1-8　2009/01

    DOI： 10.1620/tjem.217.1 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  1890. 高たんぱく質・高ナトリウム流動食PRONAによる栄養管理の有用性に関する検討 Peer-reviewed

    鈴木正徳, 竹内丙午, 菅間恒, 海野倫明, 宮崎桂介, 池田正幸, 武田安弘

    静脈経腸栄養　24　(1)　376-376　2009/01

  1891. A case of mesenteric desmoid tumor successfully treated with Tamoxifen and Sulindac Peer-reviewed

    Terutada Kobayashi, Koh Miura, Makoto Kinouchi, Toshinori Ando, Atsushi Oyama, Kazuhiro Takami, Naoyuki Kaneko, Hideaki Karasawa, Michiaki Unno, Iwao Sasaki

    Japanese Journal of Gastroenterological Surgery　42　(5)　611-616　2009

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.42.611 　

    ISSN： 1348-9372 0386-9768

  1892. Reoperation for relapsing pancreatitis after frey procedure for chronic pancreatitis Peer-reviewed

    Shinichi Egawa, Yoh Kitamura, Naoaki Sakata, Shigeru Ottomo, Hisashi Abe, Masanori Akada, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　42　(5)　466-472　2009

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.42.466 　

    ISSN： 1348-9372 0386-9768

  1893. 粘液産生胆管腫瘍(mucin-producing bile duct tumors:MPBTs)の4例の予後に関する検討

    藤川奈々子, 岡上能斗竜, 片寄友, 力山敏樹, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 阿部永, 林洋毅, 森川孝則, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    東北医学雑誌　120　(2)　209-209　2008/12

  1894. 術前放射線化学療法後に、上腸間膜静脈切離非再建でR0切除できた高度進行膵頭部癌

    嶋健太郎, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    東北医学雑誌　120　(2)　205-205　2008/12

  1895. 小腸腸間膜内に広範囲にわたり穿破した壊死性膵炎後膵仮性嚢胞に対する1手術例 Peer-reviewed

    有明恭平, 森川孝則, 大塚英郎, 元井冬彦, 佐藤俊, 富永剛, 江川新一, 海野倫明

    日本腹部救急医学会雑誌　28　(7)　969-972　2008/11

    DOI： 10.11231/jaem.28.969 　

  1896. ヘパラン硫酸はマウス膵ランゲルハンス島の形態形成やβ細胞増殖、インスリン分泌機能に重要な役割を果たしている Peer-reviewed

    高橋巌, 野口直哉, 那谷耕司, 山田修平, 金岩知之, 水本秀二, 池田崇之, 杉原一司, 浅野雅秀, 吉川雄朗, ShervaniNausheen J, 宇留野晃, 海野倫明, 菅原一幸, 高澤伸, 岡本宏, 菅原明

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　81回・31回　1T22-3　2008/11

  1897. Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting, of lymphocytes to tumor cells Peer-reviewed

    Ryutaro Asano, Hiroko Kawaguchi, Yasuhiro Watanabe, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    JOURNAL OF IMMUNOTHERAPY　31　(8)　752-761　2008/10

    DOI： 10.1097/CJI.0b013e3181849071 　

    ISSN： 1524-9557

    eISSN： 1537-4513

  1898. Preferential heterodimerization of a bispecific diabody based on a humanized anti-EGFR antibody 528 Peer-reviewed

    Ryutaro Asano, Yukiko Sone, Keiko Ikoma, Hiroki Hayashi, Takeshi Nakanishi, Mitsuo Umetsu, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    PROTEIN ENGINEERING DESIGN & SELECTION　21　(10)　597-603　2008/10

    DOI： 10.1093/protein/gzn037 　

    ISSN： 1741-0126

    eISSN： 1741-0134

  1899. PET検診で発見された硬化性腸間膜炎の1例 Peer-reviewed

    佐瀬友彦, 鹿郷昌之, 柴田近, 三浦康, 小川仁, 木内誠, 岡部光規, 安藤敏典, 西條文人, 金子直征, 唐澤秀明, 山村明寛, 福島浩平, 海野倫明, 佐々木巌

    日本臨床外科学会雑誌　69　(増刊)　455-455　2008/10

  1900. R0率向上を目指した、後腹膜・神経叢の一括郭清を膵切離に先行させた、膵頭部癌に対する膵頭十二指腸切除 Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　69　(増刊)　406-406　2008/10

  1901. 塩酸ゲムシタビン(GEM)による膵癌術前化学療法(NAC)の意義 Peer-reviewed

    元井冬彦, 乙供茂, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　69　(増刊)　289-289　2008/10

  1902. 腫瘤形成型肝内胆管癌の至適リンパ節郭清 Peer-reviewed

    吉田寛, 有明恭平, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 山本久仁治, 阿部永, 林洋毅, 森川孝則, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本臨床外科学会雑誌　69　(増刊)　288-288　2008/10

  1903. 膵頭十二指腸切除術術後に発症した劇症型Aeromonas hydrophila敗血症の1例 Peer-reviewed

    有明恭平, 吉田寛, 元井冬彦, 大塚英郎, 片寄友, 力山敏樹, 江川新一, 海野倫明

    日本外科感染症学会雑誌　5　(5)　560-560　2008/10

  1904. 私はこうしている「肝・胆道・膵手術と外科感染症発生防止対策」 肝門部胆管癌症例の周術期管理 Peer-reviewed

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    日本外科感染症学会雑誌　5　(5)　514-514　2008/10

  1905. 高齢者胃癌手術症例の検討 術前併存疾患との関連を中心に Peer-reviewed

    木内誠, 柴田近, 三浦康, 上野達也, 鹿郷昌之, 西條文人, 岡部光規, 安藤敏典, 小川仁, 羽根田翔, 海野倫明, 佐々木巖

    日本癌治療学会誌　43　(2)　909-909　2008/10

  1906. 術後GEM補助療法が無効となった再発胆道癌症例に対するS-1療法の検討 Peer-reviewed

    北村洋, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 乙供茂, 海野倫明

    日本癌治療学会誌　43　(2)　876-876　2008/10

  1907. 放射線化学療法後4年半CRで経過し胃粘膜転移を来たした中部食道癌の1例 Peer-reviewed

    佐瀬友彦, 柴田近, 三浦康, 鹿郷昌之, 木内誠, 岡部光則, 安藤敏則, 唐沢秀明, 金子直征, 山村明寛, 福島浩平, 海野倫明, 佐々木巌

    日本癌治療学会誌　43　(2)　734-734　2008/10

  1908. 大腸癌隣接臓器合併切除例の検討 Peer-reviewed

    山村明寛, 三浦康, 小川仁, 岡部光則, 木内誠, 安藤敏典, 金子直征, 唐澤秀明, 佐瀬友彦, 福島浩平, 海野倫明, 佐々木巌

    日本癌治療学会誌　43　(2)　537-537　2008/10

  1909. 膵癌切除+ゲムシタビン補助化学療法施行後の二次治療におけるTS1の有用性 Peer-reviewed

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　43　(2)　474-474　2008/10

  1910. PETはどれだけがん治療に貢献しているか 転移・再発診断への応用 胆道癌の術前診断におけるFDG-PETの有効性 Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 阿部永, 大塚英郎, 乙供茂, 岡上能斗竜, 江川新一, 海野倫明

    日本癌治療学会誌　43　(2)　353-353　2008/10

  1911. 進行、再発膵・胆道癌に対する新しい集学的治療 胆道癌 胆管癌に対する術前化学放射線療法の安全性の検討 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 小野川徹, 江川新一, 海野倫明

    日本癌治療学会誌　43　(2)　314-314　2008/10

  1912. 術前化学療法の現状と展望 消化器 切除可能胆管癌症例に対する術前放射線化学療法:第I相試験 Peer-reviewed

    片寄友, 森川孝則, 小野川徹, 岡上能斗竜, 山本久仁治, 吉田寛, 林洋毅, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    日本癌治療学会誌　43　(2)　271-271　2008/10

  1913. バイオマーカー研究 臨床から基礎への要望、基礎から臨床への要望 直腸とその他の骨盤領域(前立腺・膀胱など泌尿器系/卵巣など女性生殖器系)悪性腫瘍および肛門周囲悪性腫瘍の免疫組織化学的手法による系統的鑑別診断法の確立 Peer-reviewed

    三浦康, 石田和之, 岡部光規, 木内誠, 安藤敏典, 柴田近, 小川仁, 唐澤秀明, 金子直征, 岡上能斗竜, 山村明寛, 佐瀬友彦, 井本博文, 海野倫明, 佐々木巖

    日本癌治療学会誌　43　(2)　253-253　2008/10

  1914. 肝内胆管癌の病態・治療 腫瘤形成型肝内胆管癌の手術治療成績からみた標準術式の検討 Peer-reviewed

    吉田寛, 片寄友, 海野倫明

    肝臓　49　(Suppl.3)　A663-A663　2008/10

  1915. Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maljunction and congenital biliary cystic disease Peer-reviewed

    Hiroyuki Nakamura, Yu Katayose, Toshiki Rikiyama, Tohru Onogawa, Kuniharu Yamamoto, Hiroshi Yoshida, Hiroki Hayashi, Hideo Ohtsuka, Yutaka Hayashi, Shin-Ichi Egawa, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY　15　(5)　554-559　2008/09

    DOI： 10.1007/s00534-007-1310-x 　

    ISSN： 0944-1166

  1916. Institutional indications for islet transplantation after total pancreatectomy Peer-reviewed

    Naoaki Sakata, Shinichi Egawa, Fuyuhiko Motoi, Yukio Mikami, Masaharu Ishida, Takeshi Aoki, Shigeru Ottomo, Shoji Fukuyama, Toshiki Rikiyama, Yu Katayose, Masafumi Goto, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY　15　(5)　488-492　2008/09

    DOI： 10.1007/s00534-007-1309-3 　

    ISSN： 0944-1166

  1917. 腹腔鏡下胆嚢摘出術後に金属クリップを核とし形成された総胆管結石症の1例 Peer-reviewed

    森川孝則, 有明恭平, 佐藤俊, 富永剛, 江川新一, 海野倫明

    手術　62　(10)　1471-1474　2008/09

    Publisher:

    ISSN： 0037-4423

  1918. Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma Peer-reviewed

    Koji Fukase, Hideo Ohtsuka, Tohru Onogawa, Hiroshi Oshio, Takayuki Ii, Mitsuhisa Mutoh, Yu Katayose, Toshiki Rikiyama, Masaya Oikawa, Fuyuhiko Motoi, Shinichi Egawa, Takaaki Abe, Michiaki Unno

    CANCER SCIENCE　99　(9)　1785-1792　2008/09

    DOI： 10.1111/j.1349-7006.2008.00898.x 　

    ISSN： 1347-9032

  1919. The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer Peer-reviewed

    Masaharu Ishida, Makoto Sunamura, Toru Furukawa, Liviu P. Lefter, Rina Morita, Masanori Akada, Shinichi Egawa, Michiaki Unno, Akira Horii

    DIGESTIVE DISEASES AND SCIENCES　53　(9)　2576-2582　2008/09

    DOI： 10.1007/s10620-007-0154-1 　

    ISSN： 0163-2116

  1920. Up-regulated p27(Kip1) Reduces Matrix Metalloproteinase-9 and Inhibits Invasion of Human Breast Cancer Cells Peer-reviewed

    Masamichi Mizuma, Yu Katayose, Kuniharu Yamamoto, Satoru Shiraso, Tsuyoshi Sasaki, Shinichi Yabuuchi, Akira Oda, Kunihiro Masuda, Toshiki Rikiyama, Tohru Onogawa, Hideo Ohtsuka, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno

    ANTICANCER RESEARCH　28　(5A)　2669-2677　2008/09

    ISSN： 0250-7005

  1921. 膵癌におけるWT1発現 Peer-reviewed

    江川新一, 塚本信和, 石田晶玄, 阿部永, 林洋毅, 赤田昌紀, 元井冬彦, 片寄友, 石田和之, 森谷卓也, 堀井明, 海野倫明

    日本癌学会総会記事　67回　439-439　2008/09

  1922. 家族性膵癌におけるIGF-2の転写異常 Peer-reviewed

    阿部永, 谷地田真一, FuBaojin, LuoMigde, VillellasFellip, GogginsMichael, DonahueChristine, 林洋毅, 塚本信和, 江川新一, 海野倫明, HrubanRalph

    日本癌学会総会記事　67回　303-303　2008/09

  1923. 新規乳癌独立予後規定因子としての有機アニオントランスポーターLST-2/SLCO1B3の癌細胞特異的発現とその腫瘍生物学的意義 Peer-reviewed

    小野川徹, 鈴木貴, 片寄友, 力山敏樹, 阿部高明, 石田孝宣, 森川孝則, 岡上能斗竜, 前田晋平, 大内憲明, 笹野公伸, 江川新一, 海野倫明

    日本癌学会総会記事　67回　223-223　2008/09

  1924. 膵癌における18番染色体長腕の未知の癌抑制遺伝子の解析 Peer-reviewed

    横山智, 元井冬彦, 大塚英郎, 石田晶玄, 塚本信和, 金子直征, 江川新一, 海野倫明, 古川徹, 砂村真琴, 落谷孝広, 堀井明

    日本癌学会総会記事　67回　214-214　2008/09

  1925. 膵癌での分子標的治療に向けたS100A4を中心としたがん関連遺伝子の解析 Peer-reviewed

    塚本信和, 田畑孝洋, 顧兆ディ, 横山智, 金子直征, 古川徹, 砂村真琴, 石田昌玄, 阿部永, 林洋毅, 江川新一, 海野倫明, 堀井明

    日本癌学会総会記事　67回　213-213　2008/09

  1926. 大腸癌におけるステロイドサルファターゼとエストロゲンスルフォトランスフェラーゼの発現意義

    佐藤龍一郎, 鈴木貴, 片寄友, 三浦康, 椎葉健一, 立野紘雄, 三木康宏, 赤平純一, 山本久仁治, 井伊貴幸, 江川新一, 海野倫明, 笹野公伸

    日本癌学会総会記事　67回　197-197　2008/09

  1927. 新規Dishevelled関連蛋白:GC binding factor 2(GCF2)は、RhoAの活性化を制御する Peer-reviewed

    大塚英郎, 及川昌也, 力山敏樹, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本癌学会総会記事　67回　184-185　2008/09

  1928. 高たんぱく質・高Na流動食PRONAによる栄養管理の有用性に関する検討 Peer-reviewed

    鈴木正徳, 竹内丙午, 菅間恒, 海野倫明, 宮崎桂介, 池田正幸, 武田安弘

    New Diet Therapy　24　(2)　207-207　2008/09

  1929. 消化器病学会ガイドライン最終報告 胆石症 胆石症診療ガイドライン作成に向けて 胆石症の病態と疫学 Peer-reviewed

    正田純一, 海野倫明, 千々岩一男

    日本消化器病学会雑誌　105　(臨増大会)　A440-A440　2008/09

  1930. 慢性膵炎急性増悪をきたし、急性閉塞性胆管炎を併発した複雑型膵・胆管合流異常の1手術例 Peer-reviewed

    荒木孝明, 大塚英郎, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 山本久仁治, 阿部永, 森川孝則, 林洋毅, 乙供茂, 江川新一, 海野倫明

    日本膵・胆管合流異常研究会プロシーディングス　31　66-67　2008/09

  1931. 術前診断が可能であった胆嚢結腸瘻に対し腹腔鏡下手術を施行した1例 Peer-reviewed

    森川孝則, 佐藤俊, 深瀬耕二, 海野倫明

    日本内視鏡外科学会雑誌　13　(4)　423-427　2008/08

    DOI： 10.11477/mf.4426100216 　

  1932. 胆管内乳頭粘液腫瘍の一例 Peer-reviewed

    菅野敦, 佐藤賢一, 正宗淳, 佐藤晃彦, 廣田衛久, 菊田和弘, 粂潔, 濱田晋, 海野純, 高木康彦, 渡辺崇, 伊藤広通, 下瀬川徹, 片寄友, 海野倫明, 石田和之

    胆道　22　(3)　470-470　2008/08

    Publisher:

    ISSN： 0914-0077

    eISSN： 1883-6879

  1933. 粘液産生胆管腫(mucin-producing bile duct tumors:MPBTs)の4例の検討 Peer-reviewed

    藤川奈々子, 岡上能斗竜, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 阿部永, 森川孝則, 林洋毅, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    胆道　22　(3)　469-469　2008/08

  1934. 食道癌術後胃管浸潤を来した肝門型肝内胆管癌に下咽頭癌を合併した一症例 Peer-reviewed

    高舘達之, 山本久仁治, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 阿部永, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    胆道　22　(3)　452-452　2008/08

  1935. 大建中湯が術前経皮経肝門脈塞栓術による残肝容積肥大に及ぼす効果 Peer-reviewed

    林洋毅, 佐藤龍一郎, 片寄友, 力山敏樹, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 森川孝則, 阿部永, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    胆道　22　(3)　446-446　2008/08

  1936. 胆管癌に対する術前化学放射線療法の治療効果 Peer-reviewed

    片寄友, 岡上能斗竜, 森川孝則, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 阿部永, 大塚英郎, 元井冬彦, 江川新一, 海野倫明

    胆道　22　(3)　411-411　2008/08

  1937. 胆管癌手術における胆管断端癌陽性の取扱い 当科における胆管癌断端陽性例の臨床病理学的検討 Peer-reviewed

    岡上能斗竜, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 森川孝則, 前田晋平, 江川新一, 海野倫明

    胆道　22　(3)　351-351　2008/08

  1938. 胆道癌血管浸潤の診断と治療法の選択 MDCTによる肝門部胆管癌血管浸潤診断と門脈合併切除再建の治療成績・意義 Peer-reviewed

    力山敏樹, 片寄友, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 阿部永, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    胆道　22　(3)　330-330　2008/08

  1939. 肝門部胆管癌における減黄の意義と方法 肝門部胆管癌術前減黄 その必要性とアプローチ法 Peer-reviewed

    吉田寛, 有明恭平, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 山本久仁治, 江川新一, 海野倫明

    胆道　22　(3)　319-319　2008/08

  1940. 当科におけるpSM大腸癌、直腸癌手術症例の検討(内視鏡的切除例、経肛門的切除例の検討) Peer-reviewed

    小山淳, 三浦康, 唐沢秀明, 金子直征, 高見一弘, 佐々木宏之, 大沼忍, 木内誠, 小林照忠, 柴田近, 福島浩平, 舟山裕士, 海野倫明, 佐々木巖

    日本大腸肛門病学会雑誌　61　(8)　560-560　2008/08

  1941. Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines Peer-reviewed

    Hiroshi Oshio, Takaaki Abe, Tohru Onogawa, Hideo Ohtsuka, Takeaki Sato, Takayuki Ii, Kouji Fukase, Mitsuhisa Muto, Yu Katayose, Masaya Oikawa, Toshiki Rikiyama, Shinichi Egawa, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY　43　(7)　538-549　2008/07

    DOI： 10.1007/s00535-008-2188-3 　

    ISSN： 0944-1174

  1942. 当科で経験した膵病変を発症したvon Hippel-Lindau症候群(VHL)の2切除例 Peer-reviewed

    横山智, 元井冬彦, 川口桂, 青木豪, 大塚英郎, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1524-1524　2008/07

  1943. 大腸癌における腫瘍内エストロゲン濃度と合成酵素群との相関、および予後の検討 Peer-reviewed

    佐藤龍一郎, 鈴木貴, 片寄友, 三浦康, 椎葉健一, 山本久仁治, 井伊貴幸, 江川新一, 笹野公伸, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1504-1504　2008/07

  1944. 薬物療法により良好な経過をたどった腹腔内デスモイド腫瘍の1例 Peer-reviewed

    小林照忠, 三浦康, 木内誠, 安藤敏典, 小山淳, 高見一弘, 金子直征, 唐澤秀明, 佐々木巖, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1480-1480　2008/07

  1945. NSE産生尿膜管平滑筋肉腫の1例 Peer-reviewed

    益田邦洋, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 乙供茂, 佐藤龍一郎, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1436-1436　2008/07

  1946. 胆管癌手術における胆管切除断端の検討 Peer-reviewed

    岡上能斗竜, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 森川孝則, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1432-1432　2008/07

  1947. 早期手術により腸切除を回避できた腸回転異常症・Marfan症候群を合併した内ヘルニアの一例 Peer-reviewed

    菊地大介, 柴田近, 上野達也, 鹿郷昌之, 木内誠, 長尾宗則, 林啓一, 佐藤学, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　41　(7)　1381-1381　2008/07

  1948. 当施設における動物を使用した消化器外科領域での研修医教育の現況 Peer-reviewed

    福山尚治, 笠井憲雪, 岡田恭穂, 大塚英郎, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 徳村弘実, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1346-1346　2008/07

  1949. 結腸癌MP症例に対する至適リンパ節郭清 Peer-reviewed

    小山淳, 三浦康, 岡部光則, 木内誠, 安藤敏典, 福島浩平, 小川仁, 柴田近, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　41　(7)　1261-1261　2008/07

  1950. Type4胃癌症例の検討 Peer-reviewed

    山村明寛, 三浦康, 柴田近, 木内誠, 鹿郷昌之, 上野達也, 唐澤秀明, 金子直征, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　41　(7)　1247-1247　2008/07

  1951. 胆管癌肝切除例における周術期因子の予後への影響 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1247-1247　2008/07

  1952. 膵頭十二指腸切除術クリニカルパス定着のための工夫と効果 Peer-reviewed

    岡田恭穂, 元井冬彦, 福山尚治, 乙供茂, 阿部永, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1224-1224　2008/07

  1953. 膵臓癌におけるIGF-2の転写異常 Peer-reviewed

    阿部永, FuBaojin, LuoMigde, GogginsMichael, 江川新一, 海野倫明, DonahueChristine

    日本消化器外科学会雑誌　41　(7)　1165-1165　2008/07

  1954. 膵癌細胞における薬物輸送担体蛋白群の同時絶対定量解析に基づく薬剤耐性規定因子の同定 Peer-reviewed

    川口桂, 元井冬彦, 横山智, 青木豪, 江川新一, 海野倫明, 大峰健, 大槻純男, 寺崎哲也, 上家潤一

    日本消化器外科学会雑誌　41　(7)　1165-1165　2008/07

  1955. 重症急性膵炎の治療成績 小腸腸間膜内に広範囲にわたり穿破した壊死性膵仮性嚢胞に対する1手術例 Peer-reviewed

    有明恭平, 安部永, 森川孝則, 岡田恭穂, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1145-1145　2008/07

  1956. 浸潤性膵管癌の長期生存例、短期再発例の特徴 当科切除不能進行膵癌に対する治療成績 Peer-reviewed

    乙供茂, 江川新一, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 吉田寛, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1127-1127　2008/07

  1957. 消化器癌補助化学療法 肝・胆・膵 ジェムシタビンによる胆道癌術後補助化学療法の現状 Peer-reviewed

    大塚英郎, 片寄友, 江川新一, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1119-1119　2008/07

  1958. 消化器外科とSSI対策 肝門部胆管癌肝切除症例のSSI対策 周術期免疫増強栄養剤(IED)の有効性比較試験 Peer-reviewed

    吉田寛, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1107-1107　2008/07

  1959. 肝門部胆管癌の治療戦略 切除断端と剥離面の陰性化を目的とした術式の工夫と限界点 肝門部胆管癌の外科切除成績と新規治療戦略 断端陰性化を目指して Peer-reviewed

    力山敏樹, 片寄友, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1072-1072　2008/07

  1960. 胆嚢癌のStage別標準術式 その手技を考える 胆嚢癌手術治療 肝切除・胆管切除・膵頭十二指腸切除の意義 Peer-reviewed

    林洋毅, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 森川孝則, 大塚英郎, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1043-1043　2008/07

  1961. 最新の消化器癌補助療法 消化管 大腸癌肝転移切除例に対するmFOLFOX6補助化学療法に関する検討 Peer-reviewed

    山本久仁治, 片寄友, 浅沼拓, 佐藤正幸, 阿部友哉, 横山忠明, 阿部忠義, 竹村真一, 村田幸生, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1041-1041　2008/07

  1962. 膵癌に対する膵頭十二指腸切除術の各種手術手技 膵頭部癌に対する、後腹膜・神経叢の一括郭清を、膵切離に先行させた膵頭十二指腸切除 Peer-reviewed

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　41　(7)　1013-1013　2008/07

  1963. ヒト肝組織における薬物代謝酵素発現パターンの個人差の解析

    端秀子, 三木康宏, 藤島史喜, 佐藤龍一郎, 海野倫明, 笹野公伸

    The Journal of Toxicological Sciences　33　(Suppl.)　S155-S155　2008/06

  1964. 【いわゆる粘液産生胆管腫瘍をめぐって】 胆管内乳頭状腫瘍と膵IPMNの比較 Invited

    岡上能斗竜, 片寄友, 力山敏樹, 小野川徹, 石田和之, 江川新一, 海野倫明

    胆と膵　29　(6)　523-527　2008/06

  1965. 結腸内カプサイシン投与の結腸運動亢進・排便誘発効果とその作用機序 Invited

    林啓一, 柴田近, 三浦康, 小川仁, 上野達也, 鹿郷昌之, 木内誠, 長尾宗紀, 工藤克昌, 佐藤学, 海野倫明, 佐々木巌

    東北医学雑誌　120　(1)　80-82　2008/06

    ISSN： 0040-8700

  1966. 大腸癌5-FU耐性関連候補遺伝子の機能解析 Invited

    唐澤秀明, 三浦康, 木内誠, 岡部光規, 安藤敏典, 金子直征, 山村明寛, 佐瀬友彦, 海野倫明, 佐々木巖

    東北医学雑誌　120　(1)　62-64　2008/06

    ISSN： 0040-8700

  1967. 膵内分泌腫瘍の生物学に基づいた診断・治療法の開発 de novoインスリノーマに対するソマトスタチンアナログの増殖抑制効果 Peer-reviewed

    青木豪, 元井冬彦, 江川新一, 海野倫明

    日本内分泌外科学会総会プログラム・抄録集　20回　44-44　2008/06

  1968. Intraductal Tubular Carcinomaの一例 Peer-reviewed

    菅野敦, 佐藤賢一, 伊藤広通, 渡辺崇, 海野純, 高木康彦, 木村洋, 濱田晋, 菊田和宏, 粂潔, 廣田衛久, 佐藤晃彦, 正宗淳, 朝倉徹, 下瀬川徹, 元井冬彦, 江川新一, 海野倫明

    膵臓　23　(3)　464-464　2008/06

    Publisher:

    ISSN： 0913-0071

    eISSN： 1881-2805

  1969. 当科における膵漿液性嚢胞腺腫切除10例の検討 Peer-reviewed

    塚本信和, 岡田恭穂, 阿部永, 林洋毅, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    膵臓　23　(3)　435-435　2008/06

  1970. 当科膵癌症例における治療成績の変遷 Peer-reviewed

    乙供茂, 江川新一, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 吉田寛, 小野川徹, 岡田恭穂, 阿部永, 林洋毅, 森川孝則, 大塚英郎, 海野倫明

    膵臓　23　(3)　395-395　2008/06

  1971. Frey術後に再手術を要した特発性慢性膵炎の1例 Peer-reviewed

    北村洋, 江川新一, 有明恭平, 前田晋平, 乙供茂, 阿部永, 森川孝則, 岡田恭穂, 小野川徹, 吉田寛, 山本久仁治, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 海野倫明

    膵臓　23　(3)　380-380　2008/06

  1972. 膵癌治療の最前線 STAGE IV進行膵癌に対する術前化学療法(NAC)の効果 Peer-reviewed

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    膵臓　23　(3)　264-264　2008/06

  1973. 術後早期回復へ向けての代謝栄養学的工夫 胆管切除を伴う大量肝切除症例の周術期管理 周術期免疫増強栄養剤(IED)と厳密な血糖コントロールの有効性 Peer-reviewed

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    外科と代謝・栄養　42　(3)　7-7　2008/06

  1974. Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells Peer-reviewed

    Atsushi Kanno, Kennichi Satoh, Atsushi Masamune, Morihisa Hirota, Kenji Kimura, Jun Umino, Shin Hamada, Akihiko Satoh, Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Tooru Shimosegawa

    INTERNATIONAL JOURNAL OF CANCER　122　(12)　2707-2718　2008/06

    DOI： 10.1002/ijc.23332 　

    ISSN： 0020-7136

  1975. Granulocyte-colony stimulating factor-producing pancreatic cancer: Report of a case Peer-reviewed

    Kazuhiro Takami, Koh Miura, Heigo Takeuchi, Shin-Ichi Egawa, Takuya Moriya, Yasushi Nakamura, Atushi Tanabe, Jun-Ichi Sugita, Hideaki Karasawa, Michiaki Unno, Iwao Sasaki

    SURGERY TODAY　38　(5)　453-457　2008/05

    DOI： 10.1007/s00595-007-3636-z 　

    ISSN： 0941-1291

  1976. Optimization of glucose level to determine the stimulation index of isolated rat islets Peer-reviewed

    Naoaki Sakata, Shinichi Egawa, Shoichiro Sumi, Michiaki Unno

    PANCREAS　36　(4)　417-423　2008/05

    DOI： 10.1097/MPA.0b013e31815ccad2 　

    ISSN： 0885-3177

  1977. Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas Peer-reviewed

    Kennichi Satoh, Atsushi Kanno, Shin Hamada, Morihisa Hirota, Jun Umino, Atsushi Masamune, Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Tooru Shimosegawa

    ONCOLOGY REPORTS　19　(5)　1185-1190　2008/05

    ISSN： 1021-335X

  1978. 肝門部浸潤癌の治療戦略 肝門部胆管癌の治療戦略 術前化学放射線療法の第I相試験 Peer-reviewed

    片寄友, 小野川徹, 森川孝則, 岡上能斗竜, 力山敏樹, 江川新一, 海野倫明

    日本外科系連合学会誌　33　(3)　418-418　2008/05

  1979. Up-regulation of MSX2 enhances the malignant phenotype and is associated with Twist 1 expression in human pancreatic cancer cells Peer-reviewed

    Kennichi Satoh, Shin Hamada, Kenji Kimura, Atsushi Kanno, Morihisa Hirota, Jun Umino, Wataru Fujibuchi, Atsushi Masamune, Naoki Tanaka, Koh Miura, Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Barbara K. Vonderhaar, Tooru Shimosegawa

    AMERICAN JOURNAL OF PATHOLOGY　172　(4)　926-939　2008/04

    DOI： 10.2353/ajpath.2008.070346 　

    ISSN： 0002-9440

  1980. Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer Peer-reviewed

    Hiroyuki Sasaki, Koh Miura, Akira Horii, Naoyuki Kaneko, Wataru Fujibuchi, Larisa Kiseleva, Zhaodi Gu, Yukio Murata, Hideaki Karasawa, Takayuki Mizoi, Terutada Kobayashi, Makoto Kinouchi, Shinobu Ohnuma, Nobuki Yazaki, Michiaki Unno, Iwao Sasaki

    CANCER SCIENCE　99　(4)　711-719　2008/04

    DOI： 10.1111/j.1349-7006.2008.00725.x 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  1981. 肝胆膵外科周術期血糖管理の徹底による合併症予防の可能性 Peer-reviewed

    大塚英郎, 片寄友, 江川新一, 力山敏樹, 吉田寛, 小野川徹, 山本久仁治, 林洋毅, 森川孝則, 坂田直昭, 海野倫明

    日本外科学会雑誌　109　(臨増2)　707-707　2008/04

  1982. Gene Set Enrichment Analysisを用いたオキサリプラチン、イリノテカン、5-FU感受性に関わる機能遺伝子セットの同定 Peer-reviewed

    高見一弘, 三浦康, 藤渕航, 小林照忠, 木内誠, 安藤敏典, 小山淳, 大沼忍, 佐々木宏之, 金子直征, 唐沢秀明, 海野倫明, 佐々木巌

    日本外科学会雑誌　109　(臨増2)　660-660　2008/04

  1983. 胆道再建を伴う肝切除術における至適ドレナージ法の検討 A Prospective Randomized Trial Peer-reviewed

    吉田寛, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 岡田恭穂, 森川孝則, 林洋毅, 大塚英郎, 乙供茂, 坂田直昭, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　469-469　2008/04

  1984. 膵癌切除術後補助化学療法の最適期間 Peer-reviewed

    川口桂, 元井冬彦, 塚本信和, 横山智, 青木豪, 坂田直昭, 乙供茂, 岡田恭穂, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　637-637　2008/04

  1985. 大腸癌におけるエストロゲン合成酵素群の発現と予後の検討 Steroid sulfataseとEstrogen sulfotransferaseの発現意義 Peer-reviewed

    佐藤龍一郎, 鈴木貴, 三浦康, 椎葉健一, 力山敏樹, 片寄友, 江川新一, 笹野公伸, 海野倫明

    日本外科学会雑誌　109　(臨増2)　631-631　2008/04

  1986. ファーター乳頭部癌の長期成績と予後因子の検討 Peer-reviewed

    森川孝則, 片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 元井冬彦, 福山尚治, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　623-623　2008/04

  1987. 臨床検体微量ペプチド試料からの薬物輸送体及び代謝酵素蛋白群の網羅的同時絶対定量解析に基づく抗癌剤感受性予測 Peer-reviewed

    小野川徹, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 林洋毅, 森川孝則, 大塚英郎, 福山尚治, 元井冬彦, 岡田恭穂, 坂田直昭, 乙供茂, 上家潤一, 大槻純男, 寺崎哲也, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　584-584　2008/04

  1988. ヒト大腸癌細胞同所移植自然転移モデルを用いたリンパ節転移能と遺伝子発現プロファイルの解析(続報) Peer-reviewed

    佐々木宏之, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 高見一弘, 金子直征, 唐澤秀明, 山村明寛, 藤渕航, KiselevaLarisa, 福島浩平, 柴田近, 小川仁, 上野達也, 長尾宗紀, 海野倫明, 佐々木巌

    日本外科学会雑誌　109　(臨増2)　538-538　2008/04

  1989. 膵癌における18番染色体長腕の未知の癌抑制遺伝子の解析 Peer-reviewed

    横山智, 江川新一, 塚本信和, 青木豪, 坂田直昭, 乙供茂, 岡田恭穂, 元井冬彦, 力山敏樹, 片寄友, 堀井明, 海野倫明

    日本外科学会雑誌　109　(臨増2)　528-528　2008/04

  1990. 当科における高齢者胃癌手術症例の検討 Peer-reviewed

    木内誠, 柴田近, 三浦康, 小林照忠, 上野達也, 安藤敏典, 鹿郷昌之, 小山淳, 小川仁, 長尾宗紀, 福島浩平, 海野倫明, 佐々木巖

    日本外科学会雑誌　109　(臨増2)　500-500　2008/04

  1991. 膵癌根治術後の肝転移発生を予測する特徴的なCA19-9血中濃度動態の解析 Peer-reviewed

    岡田恭穂, 元井冬彦, 乙供茂, 坂田直昭, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　362-362　2008/04

  1992. 膵尾部仮性嚢胞に対する再手術時の最小膵切除と膵空腸吻合 Peer-reviewed

    江川新一, 元井冬彦, 乙供茂, 坂田直昭, 岡田恭穂, 三上幸夫, 福山尚治, 力山敏樹, 片寄友, 海野倫明

    日本外科学会雑誌　109　(臨増2)　328-328　2008/04

  1993. 時計遺伝子mouse Per2はヒト膵癌細胞に増殖抑制とシスプラチンへの感受性増強をもたらす Peer-reviewed

    小田聡, 片寄友, 力山敏樹, 山本久二治, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　248-248　2008/04

  1994. ソマトスタチンアナログはインスリノーマ細胞に対して、p27を介したG 1 cell cycle arrestによって増殖抑制効果をおこす Peer-reviewed

    青木豪, 元井冬彦, 江川新一, 片寄友, 力山敏樹, 福山尚治, 宮崎純一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　245-245　2008/04

  1995. EGFR標的ヒト型化二重特異性抗体のセツキシマブとの比較検討 Peer-reviewed

    渡部泰弘, 林洋毅, 浅野竜太郎, 吉田寛, 片寄友, 安井寛, 石田禎夫, 江川新一, 熊谷泉, 海野倫明

    日本外科学会雑誌　109　(臨増2)　236-236　2008/04

    Publisher:

    ISSN： 0301-4894

  1996. 進行肝門部胆管癌の新規治療戦略とMDCT仮想肝切除による術前シミュレーション Peer-reviewed

    力山敏樹, 片寄友, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 森川孝則, 岡田恭穂, 大塚英郎, 乙供茂, 坂田直昭, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　193-193　2008/04

  1997. 新規抗癌剤の導入で膵癌治療はどう変わるか? RECIST基準に準じた膵癌切除治療の効果判定 切除完全奏効率からみた術前治療の有効性評価 Peer-reviewed

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　168-168　2008/04

  1998. 術後5年以上生存例からみた進行胆嚢癌治療の再評価 Stage III以上進行胆嚢癌における予後規定因子ならびに術式の検討 Peer-reviewed

    林洋毅, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 大塚英郎, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　165-165　2008/04

  1999. FOLFOX時代の転移性肝癌に対する肝切除の位置づけ 大腸癌肝転移術後の補助化学療法としてのmFOLFOX6法の有効性と安全性に関する検討(多施設共同の第II相臨床試験の中間報告) Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 齋藤善広, 浅沼拓, 椎葉健一, 佐藤正幸, 内山哲之, 阿部友哉, 福原賢治, 横山忠明, 丹野弘晃, 阿部忠義, 黒田フサクニ, 竹村真一, 武藤満完, 江川新一, 海野倫明

    日本外科学会雑誌　109　(臨増2)　159-159　2008/04

  2000. 臨床検体情報をどう治療へむすびつけるか? 外科切除標本と生命科学情報データベースを駆使した胃癌特異的なsplicing variantの同定とその臨床応用 Peer-reviewed

    三浦康, 大沼忍, 金子直征, 堀井明, 藤渕航, LeeChristopher, 小林照忠, 木内誠, 安藤敏典, 小山淳, 佐々木宏之, 高見一弘, 唐澤秀明, 福島浩平, 柴田近, 小川仁, 鹿郷昌之, 上野達也, 山村明寛, 海野倫明, 佐々木巖

    日本外科学会雑誌　109　(臨増2)　144-144　2008/04

  2001. 膵β細胞特異的糖転移酵素EXTL3欠損マウスはβ細胞増殖能低下と耐糖能異常を生じる Peer-reviewed

    高橋巌, 那谷耕司, 野口直哉, 池田崇之, 吉川雄朗, 山内晶世, ShervaniNausheen J, 宇留野晃, 杉原一司, 浅野雅秀, 海野倫明, 高澤伸, 岡本宏, 菅原明

    糖尿病　51　(Suppl.1)　S-318　2008/04

  2002. Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis Peer-reviewed

    Yuko Muto, Yukio Mikami, Shiro Sakakibara, Atsuyuki Shimizu, Masashi Niida, Hiroshi Kataoka, Fumi Ito, Katsuyoshi Suzuki, Koji Kijima, Kazunori Maebashi, Toshihiko Takata, Muneo Hikida, Kazunori Takeda, Michiaki Unno

    Pancreas　36　(2)　125-132　2008/03

    DOI： 10.1097/MPA.0b013e3181568ed7 　

    ISSN： 0885-3177

  2003. 幽門側胃切除Uncut Roux-en Y再建症例の検討 Peer-reviewed

    柴田近, 小林照忠, 上野達也, 鹿郷昌之, 木内誠, 福島浩平, 三浦康, 小川仁, 安藤敏典, 小山淳, 長尾宗紀, 金子直征, 唐澤秀明, 林啓一, 佐藤学, 海野倫明, 佐々木巌

    日本消化器病学会雑誌　105　(臨増総会)　A397-A397　2008/03

  2004. 直腸癌と深部静脈血栓症(DVT)を発症した潰瘍性大腸炎の1例 Peer-reviewed

    山村明寛, 福島浩平, 神山篤志, 長尾宗紀, 西條文人, 小山淳, 鹿郷昌之, 小林忠照, 小川仁, 三浦康, 舟山裕士, 海野倫明, 佐々木巌

    日本消化器病学会雑誌　105　(臨増総会)　A281-A281　2008/03

  2005. 高バリアンス手術である膵頭十二指腸切除クリティカルパスを定着させる工夫 Peer-reviewed

    岡田恭穂, 元井冬彦, 福山尚治, 乙供茂, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　105　(臨増総会)　A234-A234　2008/03

  2006. 膵癌の補助療法 切除可能膵癌に対する術前化学療法の意義 Peer-reviewed

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　105　(臨増総会)　A157-A157　2008/03

  2007. 進行消化器癌の集学的治療(肝癌を除く) 胆管癌の集学的治療 Neoadjuvant chemo-radiation therapyの安全性と期待 Peer-reviewed

    片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　105　(臨増総会)　A121-A121　2008/03

  2008. 消化器疾患とnutrition support team(NST) 肝門部胆管癌症例に対する周術期経口・経腸免疫増強栄養療法の有用性 Peer-reviewed

    吉田寛, 片寄友, 海野倫明

    日本消化器病学会雑誌　105　(臨増総会)　A99-A99　2008/03

  2009. Gallbladder agenesis with a stone in the cystic duct bud Peer-reviewed

    Masaharu Ishida, Shinichi Egawa, Yoshinobu Takahashi, Masato Kohari, Yasuo Ohwada, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY　15　(2)　220-223　2008/03

    DOI： 10.1007/s00534-007-1236-3 　

    ISSN： 0944-1166

  2010. 出血性胃潰瘍を契機にNOMIを発症した1例 Peer-reviewed

    山村明寛, 三浦康, 小林照忠, 鹿郷昌之, 木内誠, 小山淳, 海野倫明, 佐々木巌

    日本腹部救急医学会雑誌　28　(2)　379-379　2008/02

  2011. Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes Peer-reviewed

    Hiroaki Yamaguchi, Minako Kobayashi, Masahiro Okada, Toshiko Takeuchi, Michiaki Unno, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Nariyasu Mano

    CANCER LETTERS　260　(1-2)　163-169　2008/02

    DOI： 10.1016/j.canlet.2007.10.040 　

    ISSN： 0304-3835

  2012. Biliopancreatic maljunction: Classification, diagnosis, and treatment Peer-reviewed

    T. Onogawa, T. Rikiyama, M. Unno, S. Matsuno

    Diseases of the Pancreas: Current Surgical Therapy　895-901　2008

    Publisher: Springer Berlin Heidelberg

    DOI： 10.1007/978-3-540-28656-1_88 　

  2013. Surgical resection of distal common bile duct carcinoma Peer-reviewed

    T. Rikiyama, M. Unno, S. Matsuno

    Diseases of the Pancreas: Current Surgical Therapy　807-815　2008

    Publisher: Springer Berlin Heidelberg

    DOI： 10.1007/978-3-540-28656-1_79 　

  2014. Surgical vascular anatomy and histology Peer-reviewed

    Y. Mikami, A. Otsuka, M. Unno

    Diseases of the Pancreas: Current Surgical Therapy　19-28　2008

    Publisher: Springer Berlin Heidelberg

    DOI： 10.1007/978-3-540-28656-1_3 　

  2015. Synchronous and Metachronous Extrapancreatic Malignant Neoplasms in Patients with Intraductal Papillary-Mucinous Neoplasm of the Pancreas Peer-reviewed

    Masaharu Ishida, Shinichi Egawa, Kei Kawaguchi, Takeshi Aoki, Naoaki Sakata, Yukio Mikami, Fuyuhiko Motoi, Tadayoshi Abe, Shoji Fukuyama, Yu Katayose, Makoto Sunamura, Michiaki Unno, Takuya Moriya, Akira Horii, Toru Furukawa

    PANCREATOLOGY　8　(6)　577-582　2008

    DOI： 10.1159/000159844 　

    ISSN： 1424-3903

  2016. Adenovirus expressing mutant p27(kip1) enhanced apoptosis and inhibited the growth of xenografted human breast cancer Peer-reviewed

    Tsuyoshi Sasaki, Yu Katayose, Kuniharu Yamamoto, Masamichi Mizuma, Satoru Shiraso, Shinichi Yabuuchi, Akira Oda, Toshiki Rikiyama, Masaya Oikawa, Toru Onogawa, Masanori Suzuki, Choon-Taek Lee, Michiaki Unno

    SURGERY TODAY　37　(12)　1073-1082　2007/12

    DOI： 10.1007/s00595-007-3546-0 　

    ISSN： 0941-1291

  2017. 家族性膵癌の一例

    川口桂, 元井冬彦, 江川新一, 片寄友, 力山敏樹, 福山尚治, 岡田恭穂, 坂田直昭, 青木豪, 横山智, 塚本信和, 海野倫明

    東北医学雑誌　119　(2)　167-167　2007/12

  2018. 胆管癌に対する術前化学放射線療法10例の検討

    森川孝則, 片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 大塚英郎, 岡上能斗竜, 江川新一, 海野倫明

    東北医学雑誌　119　(2)　165-165　2007/12

  2019. Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas Peer-reviewed

    Masaharu Ishida, Shinichi Egawa, Takeshi Aoki, Naoaki Sakata, Yukio Mikami, Fuyuhiko Motoi, Tadayoshi Abe, Shoji Fukuyama, Makoto Sunamura, Michiaki Unno, Takuya Moriya, Akira Horii, Toru Furukawa

    PANCREAS　35　(4)　348-352　2007/11

    DOI： 10.1097/mpa.0b013e31806da090 　

    ISSN： 0885-3177

  2020. 【知っておくべき胆嚢癌の診療方針】 診断 胆嚢癌の術前進展度診断法における最近の進歩 Invited Peer-reviewed

    吉田寛, 片寄友, 力山敏樹, 朝倉徹, 菅野敦, 江川新一, 海野倫明

    外科　69　(11)　1248-1254　2007/11

    Publisher:

    ISSN： 0016-593X

  2021. 当施設での膵仮性嚢胞に対する腹腔鏡下手術の経験 Peer-reviewed

    福山尚治, 江川新一, 上野達也, 鹿郷昌之, 海野倫明, 佐々木巌

    日本内視鏡外科学会雑誌　12　(7)　481-481　2007/11

  2022. 糖転移酵素EXTL3の膵β細胞特異的欠損マウスにおけるβ細胞増殖能の低下と耐糖能異常 Peer-reviewed

    高橋巌, 那谷耕司, 野口直哉, 池田崇之, 吉川雄朗, 山内晶世, ShervaniNausheen J, 杉原一司, 浅野雅秀, 宇留野晃, 海野倫明, 高澤伸, 岡本宏, 菅原明

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　80回・30回　3T6-2　2007/11

  2023. 消化管穿孔にて発症した小腸癌の一例 原発性か転移性か Peer-reviewed

    前田晋平, 三浦康, 山村明寛, 大沼忍, 長尾宗紀, 小山淳, 木内誠, 鹿郷昌之, 上野達也, 小川仁, 小林照忠, 柴田近, 福島浩平, 海野倫明, 佐々木巖

    日本臨床外科学会雑誌　68　(増刊)　1180-1180　2007/11

  2024. 大腸亜全摘後肛門周囲膿瘍を契機に発見されたFAP合併直腸癌の一例 Peer-reviewed

    山村明寛, 三浦康, 前田晋平, 大沼忍, 長尾宗紀, 小山淳, 鹿郷昌之, 小林照忠, 小川仁, 福島浩平, 舟山裕士, 海野倫明, 佐々木巌, 森谷卓也

    日本臨床外科学会雑誌　68　(増刊)　781-781　2007/11

  2025. 膵癌に対する術前化学療法の試み Peer-reviewed

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　68　(増刊)　485-485　2007/11

  2026. 胆道癌の間質浸潤診断 FDG-PETの新たな役割 Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 吉田寛, 林洋毅, 岡田恭穂, 大塚英郎, 坂田直昭, 乙供茂, 岡上能斗竜, 江川新一, 海野倫明

    日本臨床外科学会雑誌　68　(増刊)　441-441　2007/11

  2027. R0 resection for ductal pancreatic cancer - Japanese experience. Invited Peer-reviewed

    Matsuno S, Egawa S, Unno M

    Am J Surg　194　S110-S114　2007/10/01

    DOI： 10.1016/j.amjsurg.2007.05.025 　

  2028. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma Peer-reviewed

    Mitsuhisa Muto, Tohru Onogawa, Takashi Suzuki, Takanori Ishida, Toshiki Rikiyama, Yu Katayose, Noriaki Ohuchi, Hironobu Sasano, Takaaki Abe, Michiaki Unno

    CANCER SCIENCE　98　(10)　1570-1576　2007/10

    DOI： 10.1111/j.1349-7006.2007.00570.x 　

    ISSN： 1347-9032

  2029. Letton-Wilson手術が有効であった主膵管断裂を伴う膵外傷の2例 Peer-reviewed

    石田晶玄, 江川新一, 元井冬彦, 福山尚治, 片寄友, 海野倫明

    手術　61　(11)　1689-1692　2007/10

  2030. 膵臓外科領域疾患の膵島移植適応について 慢性膵炎の外科的治療についての考察 Peer-reviewed

    坂田直昭, 江川新一, 三上幸夫, 元井冬彦, 神賀貴大, 岡田恭穂, 福山尚治, 後藤昌史, 海野倫明

    移植　42　(総会臨時)　377-377　2007/10

  2031. 分離膵島の機能評価に関する基礎的研究 Peer-reviewed

    坂田直昭, 江川新一, 海野倫明

    移植　42　(総会臨時)　309-309　2007/10

  2032. 大腸癌におけるSteroid sulfataseとEstrogen sulfotransferaseの発現意義

    佐藤龍一郎, 鈴木貴, 三木康宏, 三浦康, 片寄友, 海野倫明, 笹野公伸

    日本内分泌学会雑誌　83　(2)　465-465　2007/09

  2033. Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma Peer-reviewed

    Masaharu Ishida, Shinichi Egawa, Naoaki Sakata, Yukio Mikami, Fuyuhiko Motoi, Tadayoshi Abe, Shoji Fukuyama, Makoto Sunamura, Toru Furukawa, Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY　14　(5)　522-525　2007/09

    DOI： 10.1007/s00534-006-1199-9 　

    ISSN： 0944-1166

  2034. Preoperative assessment of hilar cholangiocarcinoma by multidetector row computed tomography Peer-reviewed

    Michiaki Unno, Tadayuki Okumoto, Yu Katayose, Toshiki Rikiyama, Akihiro Sato, Fuyuhiko Motoi, Masaya Oikawa, Shinichi Egawa, Tadashi Ishibashi

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY　14　(5)　434-440　2007/09

    DOI： 10.1007/s00534-006-1191-4 　

    ISSN： 0944-1166

  2035. Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells Peer-reviewed

    Ryutaro Asano, Yasuhiro Watanabe, Hiroko Kawaguchi, Hidesuke Fukazawa, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    JOURNAL OF BIOLOGICAL CHEMISTRY　282　(38)　27659-27665　2007/09

    DOI： 10.1074/jbc.M704719200 　

    ISSN： 0021-9258

    eISSN： 1083-351X

  2036. Risk of facial splashes in four major surgical specialties in a multicentre study Peer-reviewed

    S. Endo, K. Kanemitsu, H. Ishii, M. Narita, T. Nemoto, G. Yaginuma, Y. Mikami, M. Unno, R. Hen, K. Tabayashi, T. Matsushima, H. Kunishima, M. Kaku

    JOURNAL OF HOSPITAL INFECTION　67　(1)　56-61　2007/09

    DOI： 10.1016/j.jhin.2007.05.020 　

    ISSN： 0195-6701

  2037. 慢性膵炎の外科的治療に関する検討 膵全摘術+自己膵島移植の是非について Peer-reviewed

    坂田直昭, 三上幸夫, 元井冬彦, 神賀貴大, 林洋毅, 小野川徹, 山本久仁治, 吉田寛, 力山俊樹, 福山尚治, 片寄友, 江川新一, 後藤昌史, 岡芳知, 海野倫明

    日本消化器病学会雑誌　104　(臨増大会)　A730-A730　2007/09

  2038. 肝内胆管癌の病態特性からみた外科治療の適応と限界 腫瘤形成型肝内胆管癌の手術適応 CT腫瘍内部造影効果と予後相関の観点から Peer-reviewed

    吉田寛, 片寄友, 海野倫明

    日本消化器病学会雑誌　104　(臨増大会)　A476-A476　2007/09

  2039. 胆膵癌治療成績の向上をめざして 切除後腫瘍マーカー(TM)非正常化例に対する効果からみた塩酸ゲムシタビン(GEM)補助化学療法の意義 Peer-reviewed

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　104　(臨増大会)　A423-A423　2007/09

  2040. 胆膵癌治療成績の向上をめざして 胆道癌の術前補助療法 術前放射線化学療法・化学療法の試み Peer-reviewed

    片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　104　(臨増大会)　A421-A421　2007/09

  2041. 膵・胆管合流異常術後長期成績の検討 Peer-reviewed

    大塚英郎, 吉田寛, 片寄友, 力山敏樹, 小野川徹, 山本久仁治, 林洋毅, 中村啓之, 渡部泰弘, 海野倫明

    日本膵・胆管合流異常研究会プロシーディングス　30　53-53　2007/09

  2042. Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis Peer-reviewed

    Masaharu Ishida, Makoto Sunamura, Toru Furukawa, Masanori Akada, Hiroko Fujimura, Emiko Shibuya, Shinichi Egawa, Michiaki Unnof, Akira Horii

    WORLD JOURNAL OF GASTROENTEROLOGY　13　(34)　4593-4597　2007/09

    ISSN： 1007-9327

  2043. 最新 癌の化学療法マニュアル 胆管癌 Invited Peer-reviewed

    片寄友, 江川新一, 海野倫明

    外科　69　(8)　961-965　2007/08

    Publisher:

    ISSN： 0016-593X

  2044. CDHPとsiRNAによるDPD阻害後のヒト膵癌細胞株の5-FUに対する化学感受性 Peer-reviewed

    石田晶玄, チョン・チョルン, 元井冬彦, 江川新一, 砂村眞琴, 海野倫明, 堀井明

    日本癌学会総会記事　66回　563-563　2007/08

  2045. S100A4のノックダウンによる膵癌細胞の細胞増殖及び移動の抑制 Peer-reviewed

    塚本信和, 田畑孝洋, 古川徹, 砂村眞琴, 石田晶玄, 江川新一, 海野倫明, 堀井明

    日本癌学会総会記事　66回　562-562　2007/08

  2046. ヒト大腸癌細胞株を用いたoxaliplatin、CTP-11感受性規定遺伝子の抽出と感受性予測 Peer-reviewed

    高見一弘, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 佐々木宏之, 唐澤秀明, 金子直征, 海野倫明, 佐々木巌, 藤渕航

    日本癌学会総会記事　66回　364-364　2007/08

  2047. ヒト大腸癌細胞同所移植自然転移モデルを用いたリンパ節転移に関連する遺伝子発現プロファイル解析(続報) Peer-reviewed

    佐々木宏之, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 高見一弘, 唐澤秀明, 金子直征, 海野倫明, 佐々木巌, 藤渕航, KiselevaLarisa

    日本癌学会総会記事　66回　329-329　2007/08

  2048. 【肝内結石症 最近の知見】 肝内結石症における肝内胆管癌の特徴と治療成績 Invited

    小野川徹, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 林洋毅, 大塚英郎, 江川新一, 海野倫明

    胆と膵　28　(7)　533-537　2007/07

  2049. 【膵癌早期診断・治療の新展開】 治療の新展開 膵癌に対する遺伝子治療 実験室から臨床試験へ Invited

    元井冬彦, 海野倫明

    医学のあゆみ　222　(1)　73-80　2007/07

  2050. 十二指腸癌異時性両側卵巣転移の1例 Peer-reviewed

    横山智, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 森谷卓也, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1270-1270　2007/07

  2051. ラット急性膵炎モデルにおける走査型電子顕微鏡による膵微小血管病変の観察 Peer-reviewed

    三上幸夫, 福山尚治, 坂田直昭, 元井冬彦, 江川新一, 武田和憲, 大塚愛二, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1205-1205　2007/07

  2052. 進行胆嚢癌に対する拡大手術の適応と意義 Peer-reviewed

    林洋毅, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 福山尚治, 元井冬彦, 江川新一, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1200-1200　2007/07

  2053. 幽門側胃切除術後の残胃の癌に対する臨床病理学的検討 Peer-reviewed

    小林照忠, 柴田近, 上野達也, 木内誠, 三浦康, 小山淳, 大沼忍, 佐々木宏之, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　40　(7)　1197-1197　2007/07

  2054. 腹腔鏡下胃切除術の成績と問題点 Peer-reviewed

    鹿郷昌之, 徳村弘実, 舟山裕士, 福島浩平, 柴田近, 三浦康, 小林照忠, 小川仁, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　40　(7)　1175-1175　2007/07

  2055. 肝切除、胆道再建を伴う胆道癌手術における術後経管栄養の有用性 Peer-reviewed

    佐藤龍一郎, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 小野川徹, 林洋毅, 福山尚治, 江川新一, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1110-1110　2007/07

  2056. 結腸癌fStageIII症例におけるD3郭清の検討 Peer-reviewed

    唐澤秀明, 三浦康, 小林照忠, 木内誠, 小山淳, 柴田近, 福島浩平, 舟山裕士, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　40　(7)　1107-1107　2007/07

  2057. Chronic intestinal pseudo-obstruction(CIP)に対する外科治療(5例の経験) Peer-reviewed

    上野達也, 柴田近, 小林照忠, 木内誠, 舟山裕士, 福島浩平, 内山哲之, 北山卓, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　40　(7)　1106-1106　2007/07

  2058. Stage IVa膵癌の治療戦略 切除可能膵癌に対するゲムシタビン(GEM)による術前化学療法(NAC)の試み Peer-reviewed

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1071-1071　2007/07

  2059. 胆管癌に対する拡大手術の適応と限界 治療成績向上のためには? Peer-reviewed

    力山敏樹, 片寄友, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 福山尚治, 江川新一, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1043-1043　2007/07

  2060. 肝胆膵癌に対する補助療法の位置づけ 胆管癌に対するアジュバントの現状と術前化学放射線療法の可能性 Peer-reviewed

    片寄友, 小野川徹, 力山敏樹, 山本久仁治, 吉田寛, 林洋毅, 江川新一, 福山尚治, 元井冬彦, 海野倫明

    日本消化器外科学会雑誌　40　(7)　1022-1022　2007/07

  2061. Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: A possible role of the adriamycin importer Peer-reviewed

    Kyoko Ota, Kiyoshi Ito, Jun-ichi Akahira, Naoko Sato, Tohru Onogawa, Takuya Moriya, Michlaki Unno, Takaaki Abe, Hitoshi Niikura, Tadao Takano, Nobuo Yaegashi

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY　26　(3)　334-340　2007/07

    DOI： 10.1097/01.pgp.0000236951.33914.1b 　

    ISSN： 0277-1691

  2062. Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR Peer-reviewed

    Hiroyuki Nakamura, Shingo Dan, Tetsuyuki Akashi, Michiaki Unno, Takao Yamori

    BIOLOGICAL & PHARMACEUTICAL BULLETIN　30　(6)　1181-1185　2007/06

    DOI： 10.1248/bpb.30.1181 　

    ISSN： 0918-6158

  2063. 肝門部胆管癌に対する右肝動脈合併切除・再建を伴う肝左葉切除 Invited

    海野倫明

    消化器外科　30　(7)　1029-1038　2007/06

  2064. 【急性膵炎の診療update】 動注療法 蛋白分解酵素阻害剤膵局所動注療法 ラット重症膵炎モデルの検討 Invited

    三上幸夫, 福山尚治, 江川新一, 海野倫明, 武田和憲

    医薬の門　47　(3)　246-251　2007/06

  2065. 【最新 肝胆膵手術アトラス】 腹腔鏡下膵腫瘍核出術 Invited

    福山尚治, 江川新一, 海野倫明

    手術　61　(6)　893-897　2007/06/01

  2066. Hyperglycemia and diabetic renal change in a model of polyvinyl alcohol bioartificial pancreas transplantation Peer-reviewed

    Naoaki Sakata, Shoichiro Sumi, Yvanjun Gu, Meirigeng Qi, Chiduru Yamamoto, Makoto Sunamura, Shinichi Egawa, Michiaki Unno, Seiki Matsuno, Kazutomo Inoue

    PANCREAS　34　(4)　458-465　2007/05

    DOI： 10.1097/MPA.0b013e318040d0cd 　

    ISSN： 0885-3177

  2067. 膵頭十二指腸切除後仮性動脈瘤破裂に対し特異な血管走行形態のために救命しえた1例 Peer-reviewed

    川口桂, 江川新一, 神賀貴大, 林洋毅, 小野川徹, 元井冬彦, 力山敏樹, 福山尚治, 片寄友, 海野倫明

    膵臓　22　(3)　421-421　2007/05

  2068. 当科における膵癌症例22例に対するPET-CTの経験 Peer-reviewed

    横山智, 元井冬彦, 川口桂, 塚本信和, 青木豪, 石田晶玄, 大石英和, 神賀貴大, 坂田直昭, 三上幸夫, 福山尚治, 江川新一, 海野倫明

    膵臓　22　(3)　416-416　2007/05

  2069. 胆管狭窄合併症例に対するFreyの手術の検討 Peer-reviewed

    塚本信和, 元井冬彦, 川口桂, 横山智, 青木豪, 坂田直昭, 神賀貴大, 福山尚治, 江川新一, 海野倫明

    膵臓　22　(3)　410-410　2007/05

  2070. 当科で経験した膵全摘並びに亜全摘症例の膵島移植適応に関する検討 Peer-reviewed

    坂田直昭, 元井冬彦, 三上幸夫, 石田晶玄, 川口桂, 横山智, 塚本信和, 青木豪, 大石英和, 神賀貴大, 福山尚治, 江川新一, 後藤昌史, 岡芳知, 海野倫明

    膵臓　22　(3)　389-389　2007/05

  2071. 当施設における腹腔鏡下膵切除術の経験 Peer-reviewed

    福山尚治, 江川新一, 神賀貴大, 坂田直昭, 三上幸夫, 元井冬彦, 海野倫明

    膵臓　22　(3)　387-387　2007/05

  2072. 悪性膵内分泌腫瘍に対する治療 2症例の検討を踏まえて Peer-reviewed

    青木豪, 元井冬彦, 川口桂, 横山智, 塚本信和, 坂田直昭, 神賀貴大, 福山尚治, 江川新一, 海野倫明

    膵臓　22　(3)　381-381　2007/05

  2073. 通常型膵癌切除後腫瘍マーカーの推移を利用した再発予後予測の有用性 Peer-reviewed

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    膵臓　22　(3)　380-380　2007/05

  2074. 急性膵炎重症化機序と長期予後 膵血管病変を中心とした急性膵炎重症化機序の検討 Peer-reviewed

    三上幸夫, 武田和憲, 福山尚治, 元井冬彦, 片寄友, 江川新一, 大塚愛二, 海野倫明

    膵臓　22　(3)　258-258　2007/05

    Publisher:

    ISSN： 0913-0071

    eISSN： 1881-2805

  2075. 【腫瘍外科治療の最前線】 膵の腫瘍性疾患 その他の膵内分泌腫瘍 Invited Peer-reviewed

    三上幸夫, 青木豪, 元井冬彦, 福山尚治, 片寄友, 江川新一, 柴田近, 海野倫明

    外科治療　96　(増刊)　637-642　2007/04

    Publisher:

    ISSN： 0433-2644

  2076. 【急性膵炎の診療update】 急性膵炎の病態 Grey Turner's signの謎 Invited

    武田和憲, 海野倫明, 三上幸夫

    医薬の門　47　(2)　130-132　2007/04

  2077. Reg蛋白質受容体欠損マウスの作製とそのβ細胞複製能の低下 Peer-reviewed

    那谷耕司, 高橋巌, 杉原一司, 浅野雅秀, 池田崇之, 野口直哉, 山内晶世, 吉川雄朗, ShervaniNausheen J, 海野倫明, 高沢伸, 岡本宏

    糖尿病　50　(Suppl.1)　S-161　2007/04

  2078. 【クリティカルケアに必要な分子生物学の基礎知識】 侵襲に対する生体反応の制御因子 シグナル伝達 Invited

    吉田寛, 片寄友, 力山敏樹, 小野川徹, 山本久仁治, 海野倫明

    Surgery Frontier　14　(1)　27-32　2007/03

  2079. 胃悪性リンパ腫に対する手術治療の意義 Peer-reviewed

    大沼忍, 三浦康, 小林照忠, 舟山裕士, 福島浩平, 柴田近, 高橋賢一, 小川仁, 上野達也, 木内誠, 小山淳, 佐々木宏之, 工藤克昌, 高見一弘, 神山篤史, 金子直征, 唐澤秀明, 森谷卓也, 海野倫明, 佐々木巖

    日本消化器病学会雑誌　104　(臨増総会)　A184-A184　2007/03

  2080. 膵疾患に対する内視鏡下手術の現状の検討 Peer-reviewed

    福山尚治, 江川新一, 坂田直昭, 神賀貴大, 三上幸夫, 元井冬彦, 海野倫明

    日本外科学会雑誌　108　(臨増2)　666-666　2007/03

  2081. TS1を中心とした術前化学療法後に切除した高度進行胃癌症例の検討 Peer-reviewed

    木内誠, 三浦康, 柴田近, 溝井賢幸, 小林照忠, 上野達也, 小山淳, 小川仁, 高橋賢一, 福島浩平, 舟山裕士, 海野倫明, 佐々木巌

    日本外科学会雑誌　108　(臨増2)　574-574　2007/03

  2082. 幽門側胃切除Uncut Roux-en Y再建症例の検討 Peer-reviewed

    柴田近, 小林照忠, 上野達也, 木内誠, 舟山裕士, 福島浩平, 溝井賢幸, 三浦康, 高橋賢一, 小川仁, 小山淳, 大沼忍, 佐々木宏之, 高見一弘, 金子直征, 唐澤秀明, 工藤克昌, 神山篤史, 林啓一, 海野倫明, 佐々木巖

    日本外科学会雑誌　108　(臨増2)　567-567　2007/03

  2083. 肝門部・上部胆管癌におけるリンパ節転移個数の予後規定因子としての意義 Peer-reviewed

    片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 海野倫明

    日本外科学会雑誌　108　(臨増2)　524-524　2007/03

  2084. 胆道再建を伴う肝切除術後の経管栄養の検討 Peer-reviewed

    佐藤龍一郎, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 海野倫明

    日本外科学会雑誌　108　(臨増2)　520-520　2007/03

  2085. 大腸癌のリンパ節転移に関与する遺伝子群の同定と解析 Peer-reviewed

    佐々木宏之, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 高見一弘, 唐澤秀明, 金子直征, 舟山裕士, 福島浩平, 柴田近, 高橋賢一, 小川仁, 上野達也, 佐々木巌, 海野倫明, 藤渕航, LarisaKiseleva

    日本外科学会雑誌　108　(臨増2)　433-433　2007/03

  2086. 大腸癌5-FU耐性関連遺伝子の機能解析 Peer-reviewed

    唐澤秀明, 三浦康, 溝井賢幸, 福島浩平, 柴田近, 小川仁, 小林照忠, 高橋賢一, 木内誠, 上野達也, 小山淳, 大沼忍, 佐々木宏之, 高見一弘, 金子直征, 舟山裕士, 海野倫明, 佐々木巌

    日本外科学会雑誌　108　(臨増2)　432-432　2007/03

  2087. ヒト大腸癌細胞株を用いたCPT-11,Oxaliplatin感受性・耐性遺伝子群の抽出とその臨床応用 Peer-reviewed

    高見一弘, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 佐々木宏之, 金子直征, 唐澤秀明, 舟山裕士, 福島浩平, 柴田近, 高橋賢一, 小川仁, 上野達也, 佐々木巌, 海野倫明

    日本外科学会雑誌　108　(臨増2)　426-426　2007/03

  2088. 抗癌剤投与下の膵癌における網羅的遺伝子・メタボローム解析 Peer-reviewed

    石田晶玄, 砂村眞琴, 紙健次郎, 曽我朋義, 阿部忠義, 江川新一, 堀井明, 海野倫明

    日本外科学会雑誌　108　(臨増2)　360-360　2007/03

  2089. 膵管内乳頭粘液性腫瘍のsubtypeと通常型膵癌、他臓器悪性腫瘍合併の相関 Peer-reviewed

    川口桂, 江川新一, 横山智, 青木豪, 石田晶玄, 坂田直昭, 三上幸夫, 元井冬彦, 福山尚治, 森谷卓也, 古川徹, 海野倫明

    日本外科学会雑誌　108　(臨増2)　356-356　2007/03

  2090. 先天性胆道拡張症術後の肝内結石症 Peer-reviewed

    吉田寛, 片寄友, 力山俊樹, 山本久仁治, 小野川徹, 林洋毅, 海野倫明

    日本外科学会雑誌　108　(臨増2)　343-343　2007/03

  2091. 胆道癌術前診断におけるFDG-PETの意義 リンパ節転移と間質浸潤診断について Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    日本外科学会雑誌　108　(臨増2)　297-297　2007/03

  2092. 全国膵癌登録データからみたJPS第5版取扱い規約とUICC第6版取扱い規約の比較 Peer-reviewed

    江川新一, 当間宏樹, 水元一博, 中尾昭公, 田中雅夫, 海野倫明

    日本外科学会雑誌　108　(臨増2)　203-203　2007/03

  2093. 中下部胆管癌の切除成績と適正切除範囲 治療成績向上のためには? Peer-reviewed

    力山敏樹, 片寄友, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    日本外科学会雑誌　108　(臨増2)　135-135　2007/03

  2094. 【画像診断による膵癌術前進行度診断 正診率の向上をめざして】 MDCTによる術前Stagingの評価 Peer-reviewed

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    胆と膵　28　(2)　89-95　2007/02

  2095. 急性腹症 画像診断の進歩 胃十二指腸潰瘍穿孔例の再検討 CTによる部位診断は可能か? Peer-reviewed

    上野達也, 柴田近, 内藤広郎, 赤井澤隆, 高橋道長, 菅野明弘, 後藤慎二, 長尾宗紀, 小林照忠, 木内誠, 海野倫明, 佐々木巌

    日本腹部救急医学会雑誌　27　(2)　270-270　2007/02

  2096. Expression of organic cation transporter SLC22A16 in human endometria Peer-reviewed

    Naoko Sato, Kiyoshi Ito, Toru Onogawa, Jun-Ichi Akahira, Michiaki Unno, Takaaki Abe, Hitoshi Niikura, Nobuo Yaegashi

    International Journal of Gynecological Pathology　26　(1)　53-60　2007/01

    DOI： 10.1097/01.pgp.0000225845.67245.b3 　

    ISSN： 0277-1691

  2097. Three successive cases of enteric Anisakiasis Peer-reviewed

    Masaharu Ishida, Akihiko Harada, Shinichi Egawa, Shuichi Watabe, Nobuo Ebina, Michiaki Unno

    DIGESTIVE SURGERY　24　(3)　228-231　2007

    DOI： 10.1159/000103325 　

    ISSN： 0253-4886

  2098. Surgical resection for gastric GIST with multiple liver metastases after imatinib therapy Peer-reviewed

    Ryuichiro Sato, Masaya Oikawa, Yu Katayose, Toshiki Rikiyama, Kuniharu Yamamoto, Hiroki Hayashi, Iwao Sasaki, Michiaki Unno

    Japanese Journal of Gastroenterological Surgery　40　(4)　427-432　2007

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.40.427 　

    ISSN： 1348-9372 0386-9768

  2099. 肝門部胆管癌の外科治療 Invited

    海野倫明

    東北医学雑誌　118　(2)　133-135　2006/12

    Publisher:

    ISSN： 0040-8700

  2100. 急性腹症で発症した膵粘液性嚢胞腺腫の1例 Peer-reviewed

    石田晶玄, 江川新一, 坂田直昭, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 安西良一, 丹野弘晃, 砂村眞琴, 古川徹, 海野倫明

    膵臓　21　(6)　525-529　2006/12

    DOI： 10.2958/suizo.21.525 　

  2101. 日常診療の指針 膵疾患に対する腹腔鏡下手術の現況 Invited

    福山尚治, 江川新一, 神賀貴大, 坂田直昭, 三上幸夫, 元井冬彦, 阿部忠義, 海野倫明

    外科治療　95　(6)　661-663　2006/12

    Publisher:

    ISSN： 0433-2644

  2102. 胆道癌術前診断におけるFDG-PETの意義 リンパ節転移と間質浸潤診断について Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    東北医学雑誌　118　(2)　158-159　2006/12

  2103. [A case of an elderly patient having advanced hepatocellular carcinoma with tumor thrombus in the inferior vena cava treated with chemo-radio-therapy--intraarterial infusion of weekly high dose 5-FU (WHF)] Peer-reviewed

    Yabuuchi Shinichi, Katayose Yu, Rikiyama Toshiki, Oikawa Masaya, Yamamoto Kuniharu, Onogawa Toru, Hayashi Hiroki, Muto Mitsuhisa, Unno Michiaki

    Gan To Kagaku Ryoho　33　(12)　1768-1770　2006/11

  2104. 下大静脈腫瘍栓(Vv3)を伴う進行肝細胞癌に対して放射線・肝動注化学療法を施行しQOLが改善した1例 Peer-reviewed

    薮内伸一, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 林洋毅, 武藤満完, 海野倫明

    癌と化学療法　33　(12)　1768-1770　2006/11

  2105. 【肝門部の解剖を多角的に見る】 MDCT-cholangiographyから見た肝門部の門脈分岐変異と胆管解剖 Invited

    力山敏樹, 北見昌広, 片寄友, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    胆と膵　27　(11)　827-833　2006/11

  2106. 【急性胆道炎の処置と手術 診療ガイドラインに基づく戦略】 急性胆管炎に対する緊急開腹ドレナージ Invited

    海野倫明, 小野川徹, 山本久仁治, 吉田寛, 力山敏樹, 片寄友

    手術　60　(12)　1855-1860　2006/11

  2107. 拡大肝右葉切除、尾状葉切除、門脈合併切除を施行したエホバの証人患者における肝門部胆管癌の1例 Peer-reviewed

    武藤満完, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 伊勢秀雄, 海野倫明

    胆道　20　(4)　515-521　2006/10

    Publisher: Japan Biliary Association

    DOI： 10.11210/tando1987.20.4_515 　

    ISSN： 0914-0077

    More details Close

    A 49-year-old man of the Jehovah's Witness faith was admitted with mild liver dysfunction to our hospital. Endoscopic retrograde cholangiography showed the stenosis from right hepatic duct to hilar bile duct indicating hilar cholangiocarcinoma. We performed extended right hepatectomy with total caudate lobectomy and resection of the extrahepatic bile duct. The patient and his family would not accept blood transfusion in principle. After several meetings with them to obtain informed consent, they agreed to blood transfusion when his life was threatened. Meticulous attention to hemostasis was maintained throughout the procedure using Harmonic scalpel. The operation time was 11 hours 14 min, and intraoperative total blood loss was 985 ml. Postoperatively, the patient did not require any blood transfusion and was discharged home on postoperative day 17. We had an experience that curative operation for hilar cholangiocarcinoma would be successfully performed in Jehovah's Witness patients after informed consent was obtained.

  2108. 【慢性膵炎 今日の進歩】 治療 予後改善からみた適応と限界 慢性膵炎の外科的治療 Invited

    横山忠明, 江川新一, 海野倫明

    肝・胆・膵　53　(4)　551-555　2006/10

  2109. 【腹部急性疾患の鑑別診断と初期対応】 重症急性膵炎の診断と治療 Invited

    福山尚治, 武田和憲, 三上幸夫, 坂田直昭, 神賀貴大, 元井冬彦, 阿部忠義, 江川新一, 海野倫明

    救急医学　30　(11)　1559-1565　2006/10

    Publisher:

    ISSN： 0385-8162

  2110. 術後CPT-11/MMC療法が奏功し長期CRが得られた虫垂粘液嚢胞腺癌腹膜播種の1例 Peer-reviewed

    平賀雅樹, 溝井賢幸, 小林照忠, 木内誠, 唐澤秀明, 海野倫明, 佐々木巖

    日本臨床外科学会雑誌　67　(増刊)　912-912　2006/10

  2111. 膵癌に対する塩酸ゲムシタビン化学療法施行中の間質性肺炎 Peer-reviewed

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    日本臨床外科学会雑誌　67　(増刊)　582-582　2006/10

  2112. 糖尿病性腎障害ならびに生命予後に関するカプセル化膵島異種移植の有効性 Peer-reviewed

    坂田直昭, 角昭一郎, 顧元駿, 奇梅こう, 日裏彰人, 元井冬彦, 江川新一, 砂村眞琴, 井上一知, 海野倫明

    人工臓器　35　(2)　S162-S162　2006/10

  2113. 拡張型膵管胆道合流異常の胆嚢癌・胆管癌同時重複発癌の1根治切除例 Peer-reviewed

    渡部泰弘, 片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 山本陽一朗, 福本学, 海野倫明

    日本膵管胆道合流異常研究会プロシーディングス　29回　28-28　2006/10

  2114. 膵癌登録のための連結可能匿名化プログラムの開発 Peer-reviewed

    江川新一, 田中雅夫, 元井冬彦, 福山尚治, 松野正紀, 海野倫明

    日本癌学会総会記事　65回　525-525　2006/09

  2115. PI3キナーゼ触媒サブユニットサブタイプのmRNA発現解析 Peer-reviewed

    中村啓之, 旦慎吾, 海野倫明, 矢守隆夫

    日本癌学会総会記事　65回　484-484　2006/09

  2116. 塩酸ゲムシタビン無効膵癌に対するタキサンによる2次治療 Peer-reviewed

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 海野倫明

    日本癌学会総会記事　65回　344-344　2006/09

  2117. Notch signal伝達経路を標的とした新規膵癌治療戦略 Peer-reviewed

    大石英和, 砂村真琴, 江川新一, 元井冬彦, 福山尚治, 阿部忠義, 坂田直昭, 阿部永, 大村範幸, 青木豪, 横山智, 海野倫明, 八木田秀雄

    日本癌学会総会記事　65回　311-312　2006/09

  2118. ヒト大腸癌細胞同所移植自然転移モデルを用いた転移能に相関する遺伝子発現プロファイルの解析(続報) Peer-reviewed

    佐々木宏之, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 大沼忍, 高見一弘, 金子直征, 唐澤秀明, 海野倫明, 佐々木巌, 藤渕航

    日本癌学会総会記事　65回　300-300　2006/09

  2119. ヒト大腸癌細胞株を用いたCPT-11,Oxaliplatin感受性関連遺伝子のスクリーニング Peer-reviewed

    高見一弘, 溝井賢幸, 三浦康, 小林照忠, 大沼忍, 佐々木宏之, 海野倫明, 佐々木巌

    日本癌学会総会記事　65回　281-281　2006/09

  2120. 術前化学療法後に切除した高度進行胃癌症例の検討 Peer-reviewed

    木内誠, 溝井賢幸, 柴田近, 小林照忠, 上野達也, 海野倫明, 佐々木巖

    日本癌治療学会誌　41　(2)　823-823　2006/09

  2121. 腫瘍マーカーの推移からみた膵癌化学療法の効果判定 Peer-reviewed

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本癌治療学会誌　41　(2)　686-686　2006/09

  2122. 抗上皮増殖因子受容体(EGFR)を標的とした、二重特異性抗体を用いた胆管癌養子免疫療法 Peer-reviewed

    林洋毅, 浅野竜太郎, 渡部泰弘, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 熊谷泉, 海野倫明

    日本癌治療学会誌　41　(2)　422-422　2006/09

  2123. 肝門部胆管癌の成績向上を目指して:アジュバント療法の現状と今後 Peer-reviewed

    片寄友, 力山敏樹, 及川昌也, 小野川徹, 山本久仁治, 林洋毅, 海野倫明

    日本癌治療学会誌　41　(2)　421-421　2006/09

  2124. 分子マーカーによる乳癌・大腸癌の予後と薬剤感受性の予測 新規乳癌独立予後規定因子LST-2/SLC01B3の癌細胞特異的発現とその腫瘍生物学的意義 Peer-reviewed

    小野川徹, 鈴木貴, 井伊貴幸, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 武藤満完, 佐藤龍一郎, 海野倫明

    日本癌治療学会誌　41　(2)　273-273　2006/09

  2125. 当科における非B非C型肝細胞癌肝切除例の臨床的検討 Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 及川昌也, 小野川徹, 林洋毅, 海野倫明

    肝臓　47　(Suppl.2)　A449-A449　2006/09

  2126. インスリノーマに対する腹腔鏡手術の経験 Peer-reviewed

    福山尚治, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増大会)　A1009-A1009　2006/09

  2127. 当科における悪性膵内分泌腫瘍の検討 Peer-reviewed

    三上幸夫, 福山尚治, 坂田直昭, 元井冬彦, 阿部忠義, 江川新一, 海野倫明

    日本消化器病学会雑誌　103　(臨増大会)　A1008-A1008　2006/09

  2128. 進行膵癌切除後腫瘍マーカー非正常化の臨床的意義 Peer-reviewed

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増大会)　A982-A982　2006/09

  2129. 膵がん診療におけるトランスレーショナルリサーチの現状と展望 膵癌に対するα1樹状細胞を用いた免疫治療第1相試験 Peer-reviewed

    江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増大会)　A442-A442　2006/09

  2130. 【胆嚢癌をめぐる最近の話題】 視点 肝胆道癌の転移・浸潤と転写因子Snail Peer-reviewed

    深瀬耕二, 阿部高明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 元井冬彦, 江川新一, 海野倫明

    肝・胆・膵　53　(2)　263-270　2006/08

  2131. 胆道癌にネオアジュバント放射線化学療法を施行した1例 Peer-reviewed

    小野川徹, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 吉田寛, 林洋毅, 海野倫明

    胆道　20　(3)　415-415　2006/08

  2132. 胆管内乳頭状腫瘍(intraductal papillary neoplasm of the bile duct,IPN-B)の診断と手術成績 Peer-reviewed

    片寄友, 小田聡, 力山敏樹, 小野川徹, 山本久仁治, 海野倫明

    胆道　20　(3)　388-388　2006/08

  2133. ss胆嚢癌の診断と治療 ss胆嚢癌の予後規定因子 Peer-reviewed

    林洋毅, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 海野倫明

    胆道　20　(3)　323-323　2006/08

  2134. 【腹部救急診療と情報システム】 外科手術のテレメンタリングシステムの開発と有用性の評価 Invited

    福山尚治, 渋谷和彦, 江川新一, 杉山啓輔, 佐藤大, 砂村眞琴, 海野倫明

    日本腹部救急医学会雑誌　26　(5)　633-636　2006/07

    DOI： 10.11231/jaem1993.26.633 　

  2135. 【粘液産生胆管腫瘍の新展開と問題点】 粘液産生胆管腫瘍外科切除例の検討 Invited

    小田聡, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 林洋毅, 海野倫明

    胆と膵　27　(7)　487-493　2006/07

  2136. 【長期生存膵管癌の臨床と画像】 全国集計による長期生存膵管癌の実態 Invited

    江川新一, 砂村眞琴, 松野正紀, 海野倫明

    消化器画像　8　(4)　413-419　2006/07

    DOI： 10.11477/mf.1427100173 　

  2137. 【消化器外科における非観血的ドレナージ】 膵 膵仮性嚢胞,膵膿瘍 Invited

    三上幸夫, 佐藤晃彦, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 朝倉徹, 下瀬川徹, 海野倫明

    臨床外科　61　(7)　935-939　2006/07

    Publisher:

    DOI： 10.11477/mf.1407100929 　

    ISSN： 0386-9857

  2138. 直腸骨盤内腫瘍のリンパ節転移診断に関するPET(PET-CT)の有用性の検討 Peer-reviewed

    平賀雅樹, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　39　(7)　1357-1357　2006/07

  2139. 当科にて経験したIPMN切除例における同時性・異時性他臓器癌合併例の検討 Peer-reviewed

    青木豪, 元井冬彦, 石田晶玄, 大石英和, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1346-1346　2006/07

  2140. 胆道癌肝切除症例における閉鎖式低圧持続吸引ドレナージの効果 Peer-reviewed

    益田邦洋, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 武藤満完, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1327-1327　2006/07

  2141. GISTとの鑑別に難渋した退形成性膵管癌(破骨細胞型巨細胞癌)の1例 Peer-reviewed

    横山智, 砂村眞琴, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 海野倫明, 渡辺みか

    日本消化器外科学会雑誌　39　(7)　1312-1312　2006/07

  2142. 重症急性膵炎における輸液管理 Peer-reviewed

    三上幸夫, 福山尚治, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1307-1307　2006/07

  2143. 肝門部胆管癌術後補助化学療法の可能性 Peer-reviewed

    片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 林洋毅, 小田聡, 武藤満完, 佐藤龍一郎, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1301-1301　2006/07

  2144. 切除不能胆管癌に対する集学的治療-その後の経口化学療法 Peer-reviewed

    佐藤龍一郎, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1301-1301　2006/07

  2145. 胆嚢癌の手術術式の検討 Peer-reviewed

    林洋毅, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1300-1300　2006/07

  2146. 小腸リンパ管拡張症の一例 Peer-reviewed

    林啓一, 舟山裕士, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　39　(7)　1246-1246　2006/07

  2147. 膵癌治療における抗癌剤に関わる遺伝子と臨床成績 Peer-reviewed

    石田晶玄, 元井冬彦, チョン・チョルウン, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 堀井明, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1191-1191　2006/07

  2148. Whole Genome Amplificationを利用した膵癌の遺伝子診断 Peer-reviewed

    阿部忠義, 砂村眞琴, 江川新一, 福山尚治, 元井冬彦, 福重真一, 堀井明, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1180-1180　2006/07

  2149. 膵頭十二指腸切除術後のクリニカルパス Peer-reviewed

    江川新一, 砂村眞琴, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1162-1162　2006/07

  2150. 膵全摘術の適応と術後長期成績 Peer-reviewed

    大石英和, 江川新一, 元井冬彦, 阿部忠義, 福山尚治, 砂村真琴, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1153-1153　2006/07

  2151. 脾疾患に対する鏡視下手術の利点の検討 Peer-reviewed

    福山尚治, 江川新一, 三上幸夫, 元井冬彦, 阿部忠義, 砂村眞琴, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1131-1131　2006/07

  2152. 放射線化学療法後再発した肛門扁平上皮癌の2例 Peer-reviewed

    田中直樹, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　39　(7)　1107-1107　2006/07

  2153. 原発性虫垂腫瘍8例の検討 Peer-reviewed

    金子直征, 溝井賢幸, 小林照忠, 平賀雅樹, 木内誠, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　39　(7)　1093-1093　2006/07

  2154. 大腸癌細胞同所移植転移モデルでの転移能に相関する遺伝子発現プロファイル解析(続報) Peer-reviewed

    佐々木宏之, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 海野倫明, 佐々木巌, 藤渕航

    日本消化器外科学会雑誌　39　(7)　1078-1078　2006/07

  2155. 胃悪性リンパ腫に対する手術治療の意義 Peer-reviewed

    大沼忍, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 柴田近, 森谷卓也, 海野倫明, 佐々木巖

    日本消化器外科学会雑誌　39　(7)　1070-1070　2006/07

  2156. 詳細な病理学的検討により診断した胃未分化癌の1例 Peer-reviewed

    高見一弘, 佐々木巌, 海野倫明, 森谷卓也, 溝井賢幸, 柴田近, 三浦康, 小林照忠, 平賀雅樹, 木内誠

    日本消化器外科学会雑誌　39　(7)　1068-1068　2006/07

  2157. 巨大な1型早期胃癌を合併したCronkhite-Canada症候群の1例 Peer-reviewed

    唐澤秀明, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 森谷卓也, 海野倫明, 佐々木巌

    日本消化器外科学会雑誌　39　(7)　1062-1062　2006/07

  2158. 胆膵癌における化学療法の有用性 臨床病理学的因子からみた通常型膵癌切除後補助療法としての塩酸ゲムシタビンの有用性 Peer-reviewed

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本消化器外科学会雑誌　39　(7)　1007-1007　2006/07

  2159. 直腸・骨盤内腫瘍のリンパ節転移の評価に対するFDG-PETの有用性の検討 Peer-reviewed

    平賀雅樹, 溝井賢幸, 小林照忠, 木内誠, 田中直樹, 村田幸生, 大沼忍, 佐々木宏之, 高見一弘, 金子直征, 唐澤秀明, 佐々木巌, 海野倫明

    日本大腸肛門病学会雑誌　59　(7)　414-414　2006/07

  2160. Humanization of the bispecific epidermal growth factor receptor x CD3 diabody and its efficacy as a potential clinical reagent Peer-reviewed

    Ryutaro Asano, Yukiko Sone, Koki Makabe, Kouhei Tsumoto, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo, Izumi Kumagai

    CLINICAL CANCER RESEARCH　12　(13)　4036-4042　2006/07

    DOI： 10.1158/1078-0432.CCR-06-0059 　

    ISSN： 1078-0432

    eISSN： 1557-3265

  2161. Diagnosis and surgical treatment for primary liver gastrinoma: Report of a case Peer-reviewed

    Chikashi Shibata, Hiroo Naito, Yuji Funayama, Kouhei Fukushima, Ken-Ichi Takahashi, Michiaki Unno, Iwao Sasaki

    DIGESTIVE DISEASES AND SCIENCES　51　(6)　1122-1125　2006/06

    DOI： 10.1007/s10620-006-8018-7 　

    ISSN： 0163-2116

  2162. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 Peer-reviewed

    H Yamaguchi, M Okada, S Akitaya, H Ohara, T Mikkaichi, H Ishikawa, M Sato, M Matsuura, T Saga, M Unno, T Abe, N Mano, T Hishinuma, J Goto

    JOURNAL OF LIPID RESEARCH　47　(6)　1196-1202　2006/06

    DOI： 10.1194/jlr.M500532-JLR200 　

    ISSN： 0022-2275

  2163. 【転移性肝癌の新たな治療戦略】 大腸癌肝転移に対する肝切除術式選択と術後補助化学療法の位置づけ Invited

    山本久仁治, 片寄友, 力山敏樹, 及川昌也, 小野川徹, 林洋毅, 武藤満完, 海野倫明

    消化器科　42　(6)　588-594　2006/06

  2164. PanIN病変,膵癌のWhole Genome Amplificationを用いたゲノム解析 Peer-reviewed

    阿部忠義, 砂村眞琴, 江川新一, 福山尚治, 元井冬彦, 福重真一, 堀井明, 海野倫明

    膵臓　21　(3)　249-249　2006/06

  2165. Notch signaling pathwayを標的とした腫瘍血管新生抑制療法 Peer-reviewed

    大石英和, 砂村真琴, 江川新一, 元井冬彦, 福山尚治, 阿部忠義, 阿部永, 大村範幸, 海野倫明, 八木田秀雄

    膵臓　21　(3)　249-249　2006/06

  2166. 膵外傷9例の検討 Peer-reviewed

    石田晶玄, 元井冬彦, 塚本信和, 横山智, 青木豪, 大石英和, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    膵臓　21　(3)　239-239　2006/06

  2167. 当施設における膵疾患に対する腹腔鏡下手術の現況 Peer-reviewed

    福山尚治, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    膵臓　21　(3)　235-235　2006/06

  2168. 悪性インスリノーマ多発肝転移に対しオクトレオチドにて長期生存を得られている1例 Peer-reviewed

    青木豪, 元井冬彦, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    膵臓　21　(3)　224-224　2006/06

  2169. 膵癌進行度診断 画像診断はどこまで正確か MD-CTを用いた膵癌術前Stagingの評価:病理所見との対比 Peer-reviewed

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    膵臓　21　(3)　191-191　2006/06

  2170. 【胆管癌の診断と治療】 胆管癌に対する化学療法 Invited

    片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 小田聡, 海野倫明

    外科治療　94　(5)　809-816　2006/05

    Publisher:

    ISSN： 0433-2644

  2171. 膵内分泌腫瘍を合併したvon Hippel-Lindau病の2例 Peer-reviewed

    阿部忠義, 江川新一, 福山尚治, 元井冬彦, 三上幸夫, 砂村眞琴, 海野倫明

    家族性腫瘍　6　(2)　A48-A48　2006/05

  2172. マルチスライスCTによる胆道癌診断 Peer-reviewed

    海野倫明, 片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 石橋忠司, 松野正紀

    肝胆膵　49　(3)　309-314　2006/04

  2173. Farnesoid X receptor, hepatocyte nuclear factors 1 alpha and 3 beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene Peer-reviewed

    H Ohtsuka, T Abe, T Onogawa, N Kondo, T Sato, H Oshio, H Mizutamari, T Mikkaichi, M Oikawa, T Rikiyama, Y Katayose, M Unno

    JOURNAL OF GASTROENTEROLOGY　41　(4)　369-377　2006/04

    DOI： 10.1007/s00535-006-1784-3 　

    ISSN： 0944-1174

  2174. 【胆膵腫瘍治療成績に関する最新データとその評価】 悪性膵内分泌腫瘍 治療成績に関する最新のデータ Invited

    三上幸夫, 砂村眞琴, 青木豪, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 柴田近, 海野倫明

    胆と膵　27　(4)　243-247　2006/04

  2175. 胎児期マウス肝臓ではInsulinが発現している Peer-reviewed

    高沢伸, 村上晶子, 小野川徹, 那谷耕司, 池田崇之, 山内晶世, 高橋巌, 吉川雄朗, 野口直哉, 海野倫明, 岡本宏

    糖尿病　49　(Suppl.1)　S263-S263　2006/04

  2176. 膵頭部リンパ管腫の1例 Peer-reviewed

    石田晶玄, 塚本信和, 横山智, 青木豪, 大石英和, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増総会)　A313-A313　2006/03

  2177. 膵腺扁平上皮癌切除例の検討 Peer-reviewed

    元井冬彦, 古川徹, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増総会)　A281-A281　2006/03

  2178. 当科における膵漿液性嚢胞腺腫(serous cystadenoma)切除10例の検討 Peer-reviewed

    青木豪, 元井冬彦, 横山智, 塚本信和, 石田晶玄, 大石英和, 福山尚治, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    日本消化器病学会雑誌　103　(臨増総会)　A228-A228　2006/03

  2179. 小腸上皮を標的としたdrug delivery systemを用いた大腸全摘後の小腸adaptationの誘導の試み Peer-reviewed

    羽根田祥, 福島浩平, 舟山裕士, 柴田近, 高橋賢一, 小川仁, 渡辺和宏, 工藤克昌, 神山篤史, 林啓一, 海野倫明, 佐々木巖

    日本消化器病学会雑誌　103　(臨増総会)　A161-A161　2006/03

  2180. 高度進行胆道癌への挑戦 血行改変により切除し得た肝門部胆管癌の切除経験 Peer-reviewed

    渡部泰弘, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 海野倫明

    日本外科学会雑誌　107　(臨増2)　693-693　2006/03

  2181. 血管新生抑制抗体を用いた新規膵癌治療 Peer-reviewed

    大石英和, 砂村真琴, 元井冬彦, 阿部永, 大村範幸, 青木豪, 福山尚治, 江川新一, 八木田秀雄, 海野倫明

    日本外科学会雑誌　107　(臨増2)　564-564　2006/03

  2182. DPD活性阻害は5-FUを用いた膵癌治療に有用か Peer-reviewed

    鄭哲雲, 石田晶玄, 青木豪, 大石英和, 大村範幸, 阿部永, 三上幸夫, 阿部忠義, 元井冬彦, 福山尚治, 江川新一, 砂村眞琴, 古川徹, 堀井明, 海野倫明

    日本外科学会雑誌　107　(臨増2)　561-561　2006/03

  2183. 当施設におけるインスリノーマに対する腹腔鏡手術の経験 Peer-reviewed

    福山尚治, 江川新一, 三上幸夫, 元井冬彦, 阿部忠義, 砂村眞琴, 海野倫明

    日本外科学会雑誌　107　(臨増2)　515-515　2006/03

  2184. 膵癌術中腹腔洗浄細胞診の意義 Peer-reviewed

    元井冬彦, 阿部永, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本外科学会雑誌　107　(臨増2)　511-511　2006/03

  2185. 18番染色体導入膵癌細胞株を材料としたマイクロアレイによる癌抑制遺伝子の検索 Peer-reviewed

    石田晶玄, 大石英和, 大村範幸, 阿部永, 三上幸夫, 阿部忠義, 元井冬彦, 福山尚治, 江川新一, 砂村眞琴, 堀井明, 海野倫明

    日本外科学会雑誌　107　(臨増2)　509-509　2006/03

  2186. LST-2の大腸癌における発現 Peer-reviewed

    井伊貴幸, 小野川徹, 深瀬耕二, 武藤満完, 佐藤龍一郎, 三国潤一, 立野紘雄, 溝井賢幸, 柴田近, 椎葉健一, 力山敏樹, 片寄友, 佐々木巌, 海野倫明

    日本外科学会雑誌　107　(臨増2)　465-465　2006/03

  2187. 好中球除去によるラット重症急性膵炎におけるBacterial translocation(BT)の病態解明 Peer-reviewed

    三上幸夫, 武田和憲, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明, KeckTobias, HoptUlrich

    日本外科学会雑誌　107　(臨増2)　446-446　2006/03

  2188. 非B非C型肝細胞癌の肝切除例についての臨床的検討 Peer-reviewed

    山本久仁治, 片寄友, 力山敏樹, 及川昌也, 小野川徹, 林洋毅, 海野倫明

    日本外科学会雑誌　107　(臨増2)　444-444　2006/03

  2189. Whole Genome AmplificationとLaser Capture Microdissectionによる家族性膵癌の染色体異常の解析 Peer-reviewed

    阿部忠義, GogginsMichael, HrubanRalph, 砂村眞琴, 海野倫明

    日本外科学会雑誌　107　(臨増2)　382-382　2006/03

  2190. 胆汁酸はSnailの誘導を介しE-cadherinを抑制する Peer-reviewed

    深瀬耕二, 井伊貴幸, 武藤満完, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 海野倫明

    日本外科学会雑誌　107　(臨増2)　321-321　2006/03

  2191. 肝門部胆管癌の外科治療 適応の拡大・術前処置の必要性について 進行肝門部胆管癌の外科治療と適応 Peer-reviewed

    力山敏樹, 片寄友, 及川昌也, 山本久仁治, 小野川徹, 海野倫明

    日本外科学会雑誌　107　(臨増2)　131-131　2006/03

  2192. 急性膵炎に対する輸液と栄養管理 重症急性膵炎における体液変動と輸液管理 Peer-reviewed

    三上幸夫, 武田和憲, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    日本腹部救急医学会雑誌　26　(2)　234-234　2006/02

  2193. 高齢者胆道炎:診療ガイドラインをどのように実地臨床に応用するか? 高齢者胆道炎に対する治療方針 ガイドライン作製にあたって Peer-reviewed

    海野倫明

    日本腹部救急医学会雑誌　26　(2)　220-220　2006/02

  2194. [Indication and significance of hepatopancreatoduodenectomy for gallbladder carcinoma] Invited

    Rikiyama Toshiki, Hayashi Hiroki, Katayose Yu, Oikawa Masaya, Unno Michiaki

    Nippon Rinsho　64 Suppl 1　578-582　2006/01

  2195. [Multimodal therapy for unresectable upper and hilar bile duct carcinoma] Peer-reviewed

    Katayose Yu, Oda Akira, Oikawa Masaya, Rikiyama Toshiki, Unno Michiaki

    Nippon Rinsho　64 Suppl 1　547-550　2006/01

  2196. [Diagnosis of invasion of tumor depth and surgical decision in gallbladder carcinoma] Invited

    Unno Michiaki, Katayose Yu, Rikiyama Toshiki, Oikawa Masaya, Yamamoto Kuniharu, Hayashi Hiroki

    Nippon Rinsho　64 Suppl 1　488-492　2006/01

  2197. [Chemoradiation therapy and immunotherapy for pancreatic cancer] Invited

    Egawa Shinichi, Motoi Fuyuhiko, Fukuyama Shoji, Sunamura Makoto, Unno Michiaki

    Nippon Rinsho　64 Suppl 1　258-263　2006/01

  2198. 【重症急性膵炎の病態・診断・治療】 感染性膵壊死に対する新しいアプローチ 腹腔鏡補助下ネクロセクトミー Invited

    福山尚治, 武田和憲, 三上幸夫, 江川新一, 砂村眞琴, 海野倫明

    胆と膵　27　(1)　51-53　2006/01

  2199. 【重症急性膵炎の病態・診断・治療】 急性壊死性膵炎発症早期におけるvasospasmと膵虚血・膵壊死 Invited

    武田和憲, 木村憲治, 三上幸夫, 海野倫明

    胆と膵　27　(1)　13-21　2006/01

  2200. 【膵癌・胆道癌の診断と治療 最新の研究動向】 胆道癌 特論 胆嚢癌における肝膵合併切除術の意義 Invited

    力山敏樹, 林洋毅, 片寄友, 及川昌也, 海野倫明

    日本臨床　64　(増刊1)　578-582　2006/01

  2201. 【膵癌・胆道癌の診断と治療 最新の研究動向】 胆道癌 胆道癌の治療 進行・再発胆道癌の治療/集学的治療 切除不能進行胆管癌の集学的治療 Peer-reviewed

    片寄友, 小田聡, 及川昌也, 力山敏樹, 海野倫明

    日本臨床　64　(増刊1 膵癌・胆道癌の診断と治療)　547-550　2006/01

  2202. 【膵癌・胆道癌の診断と治療 最新の研究動向】 胆道癌 胆道癌の治療 早期胆道癌の治療/胆嚢癌の外科療法 胆嚢癌の深達度診断と手術 Peer-reviewed

    海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅

    日本臨床　64　(増刊1 膵癌・胆道癌の診断と治療)　488-492　2006/01

  2203. 【膵癌・胆道癌の診断と治療 最新の研究動向】 膵癌 膵癌の治療 進行・再発膵癌の治療/集学的治療 放射線化学療法と免疫療法 Peer-reviewed

    江川新一, 元井冬彦, 福山尚治, 砂村眞琴, 海野倫明

    日本臨床　64　(増刊1 膵癌・胆道癌の診断と治療)　258-263　2006/01

  2204. 血行改変により切除し得た高度進行肝門部胆管癌の1症例 Peer-reviewed

    渡部泰弘, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 海野倫明

    東北医学雑誌　117　(2)　190-190　2005/12

  2205. 膵腺扁平上皮癌の4切除例 Peer-reviewed

    元井冬彦, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    東北医学雑誌　117　(2)　185-186　2005/12

  2206. Autoimmune pancreatitis with hepatic inflammatory pseudotumor Peer-reviewed

    A Kanno, K Satoh, K Kimura, A Masamune, T Asakura, M Unno, S Matsuno, T Moriya, T Shimosegawa

    PANCREAS　31　(4)　420-423　2005/11

    DOI： 10.1097/01.mpa.0000179732.46210.da 　

    ISSN： 0885-3177

  2207. 【外科診療における材料・器具・装置のすべて】 装置 ベッセルシーリングシステム Peer-reviewed

    福山尚治, 江川新一, 砂村眞琴, 海野倫明

    外科　67　(12)　1555-1558　2005/11

  2208. Successful treatment of intraoperative heart failure caused by ampulla cardiomyopathy by intra-aortic balloon pumping and percutaneous cardiopulmonary support: Report of a case Peer-reviewed

    S Yabuuchi, K Miura, K Shiiba, C Shibata, S Ishii, T Mizoi, Y Ejima, T Horinouchi, K Iwabuchi, K Oda, M Unno, R Morita, K Nagaya, Y Nitta, S Matsuno, Sasaki, I

    SURGERY TODAY　35　(10)　874-878　2005/10

    DOI： 10.1007/s00595-005-3009-4 　

    ISSN： 0941-1291

  2209. [Low-dose cisplatin plus 5-fluorouracil with radiotherapy for unresectable upper and hilar bile duct carcinoma] Peer-reviewed

    Oda Akira, Katayose Yu, Rikiyama Toshiki, Oikawa Masaya, Yamamoto Kuniharu, Hayashi Hiroki, Unno Michiaki

    Gan To Kagaku Ryoho　32　(11)　1615-1617　2005/10

  2210. 若年女児に発症した膵管胆道合流異常・胆道拡張症に伴う進行胆管癌の1例 Peer-reviewed

    和田基, 佐藤智行, 天江新太郎, 石井智浩, 吉田茂彦, 海野倫明, 林富

    日本膵管胆道合流異常研究会プロシーディングス　28回　28-28　2005/10

  2211. 食道・胃静脈瘤に対する手術例の検討 手術症例の推移とHassab手術の適応について Peer-reviewed

    大塩博, 片寄友, 力山敏樹, 及川昌也, 林洋毅, 小野川徹, 海野倫明

    日本門脈圧亢進症学会雑誌　11　(2)　160-165　2005/10

    DOI： 10.11423/jsph1999.11.2_160 　

  2212. 胆道ステント療法の意義 進行上部・肝門部胆管癌に対する集学的治療 Peer-reviewed

    小田聡, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅, 海野倫明

    癌と化学療法　32　(11)　1615-1617　2005/10

  2213. 肝門部胆管癌の術式選択と治療成績の時代変遷 Peer-reviewed

    海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林洋毅

    日本臨床外科学会雑誌　66　(増刊)　260-260　2005/10

  2214. Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8(+) T cells Peer-reviewed

    N Arase, A Takeuchi, M Unno, S Hirano, T Yokosuka, H Arase, T Saito

    INTERNATIONAL IMMUNOLOGY　17　(9)　1227-1237　2005/09

    DOI： 10.1093/intimm/dxh299 　

    ISSN： 0953-8178

  2215. 胆管細胞癌の腫瘍内造影効果と予後相関 Peer-reviewed

    及川昌也, 海野倫明, 片寄友, 力山敏樹, 山本久仁治, 松野正紀

    日本消化器病学会雑誌　102　(臨増大会)　A841-A841　2005/09

  2216. 肝拡大葉切除術後にMRSA関連糸球体腎炎を併発した肝門部胆管癌の3症例 Peer-reviewed

    小田聡, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 松野正紀

    日本消化器病学会雑誌　102　(臨増大会)　A835-A835　2005/09

  2217. 肝門部胆管癌根治術後に異時性発生をきたした2例 Peer-reviewed

    佐藤龍一郎, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 松野正紀

    日本消化器病学会雑誌　102　(臨増大会)　A834-A834　2005/09

  2218. 大腸癌におけるLST-2の発現 Peer-reviewed

    井伊貴幸, 海野倫明, 小野川徹, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 深瀬耕二, 武藤満完, 松野正紀

    日本消化器病学会雑誌　102　(臨増大会)　A800-A800　2005/09

  2219. 転移性肝癌に対する新たな治療戦略 大腸癌肝転移に対する肝切除術式選択と術後化学療法の意義 Peer-reviewed

    山本久仁治, 海野倫明, 片寄友

    日本消化器病学会雑誌　102　(臨増大会)　A586-A586　2005/09

  2220. 根治度Cから見た切除不能肝門部・上部胆管癌への化学放射療法の意義 Peer-reviewed

    片寄友, 海野倫明, 山本久仁治

    日本癌治療学会誌　40　(2)　582-582　2005/09

  2221. 大腸癌肝転移に対する系統的肝切除の意義 Peer-reviewed

    山本久仁治, 海野倫明, 片寄友

    日本癌治療学会誌　40　(2)　394-394　2005/09

  2222. チアゾリジン誘導体によるREG(Regenerating gene)遺伝子の発現抑制とがん細胞の増殖抑制 Peer-reviewed

    高沢伸, 山内晶世, 高橋巌, 桑名文二, 那谷耕司, 野口直哉, 池田崇之, 吉川雄朗, 小野川徹, 海野倫明, 鈴木巌, 岡本宏

    日本癌学会総会記事　64回　312-312　2005/09

    Publisher:

    ISSN： 0546-0476

  2223. 大腸癌におけるLST-2発現 Peer-reviewed

    井伊貴幸, 小野川徹, 深瀬耕二, 武藤満完, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 海野倫明

    日本癌学会総会記事　64回　272-272　2005/09

  2224. Characterization of the organic cation transporter SLC22A16: A doxorubicin importer Peer-reviewed

    M Okabe, M Unno, H Harigae, M Kaku, Y Okitsu, T Sasaki, T Mizoi, K Shiiba, H Takanaga, T Terasaki, S Matsuno, Sasaki, I, S Ito, T Abe

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　333　(3)　754-762　2005/08

    DOI： 10.1016/j.bbrc.2005.05.174 　

    ISSN： 0006-291X

  2225. 新規乳癌独立予後規定因子LST-2/SLC01B3の癌細胞特異的発現とその腫瘍生物学的意義 Peer-reviewed

    小野川徹, 海野倫明, 鈴木貴, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 井伊貴幸, 笹野公伸, 松野正紀

    日本外科学会雑誌　106　(臨増)　124-124　2005/04

  2226. 肝切除術後管理（術後肝不全対策を含めて） Peer-reviewed

    及川昌也, 海野倫明, 片寄 友, 力, 山本久仁治, 武藤満完, 松野

    消化器外科　28　(4)　459-463　2005/04

  2227. 【胆道疾患の臨床 最近の進歩】 胆道癌 胆嚢癌の手術と遠隔成績(解説/特集)

    海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 松野正紀

    臨床消化器内科(0911-601X)　20　(7)　1025-1030　2005/04

  2228. 自己免疫性膵炎に合併した炎症性肝偽腫瘍の一例 Peer-reviewed

    菅野敦, 朝倉徹, 佐藤賢一, 正宗淳, 木村憲治, 菊田和宏, 佐藤真広, 粂潔, 鈴木範明, 下瀬川徹, 海野倫明, 松野正紀

    日本消化器病学会雑誌　102　(臨増総会)　A349-A349　2005/03

  2229. イマチニブ投与後に切除し得た胃原発GIST多発肝転移の一例 Peer-reviewed

    佐藤龍一郎, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 渡部泰弘, 松野正紀

    日本消化器病学会雑誌　102　(臨増総会)　A321-A321　2005/03

  2230. 肝内胆管癌の腫瘍内造影効果と治癒切除後予後との関係 Peer-reviewed

    及川昌也, 海野倫明, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 松野正紀

    日本消化器病学会雑誌　102　(臨増総会)　A290-A290　2005/03

  2231. Effect of ileo-jejunal transposition on ileal longitudinal smooth muscle contractility in vitro in rats Peer-reviewed

    C Shibata, Y Funayama, K Fukushima, T Ueno, M Nagao, H Naito, M Unno, K Shiiba, S Matsuno, Sasaki, I

    JOURNAL OF GASTROINTESTINAL SURGERY　8　(8)　1083-1089　2004/12

    DOI： 10.1016/j.gassur.2004.03.003 　

    ISSN： 1091-255X

  2232. 【肝病態生理研究のあゆみ】 癌細胞における胆汁酸トランスポーターの役割 Peer-reviewed

    大塩博, 海野倫明, 小野川徹, 大塚英郎, 井伊貴幸, 深瀬耕二, 武藤満完, 松野正紀, 阿部高明

    薬理と治療　32　(Suppl.2)　S205-S206　2004/12

  2233. ヒト腎臓特異的に発現しジゴキシン輸送を担う新規有機アニオントランスポーターの単離と機能解析及びラット相同遺伝子の同定 Peer-reviewed

    鈴木健弘, 三日市剛, 小野川徹, 種本雅之, 水溜浩弥, 岡田匡弘, 茶木辰治, 増田智先, 徳井太郎, 江藤伸晃, 阿部倫明, 佐藤文俊, 海野倫明, 菱沼隆則, 乾賢一, 後藤順一, 伊藤貞嘉, 阿部高明

    日本高血圧学会総会プログラム・抄録集　27回　48-48　2004/10

  2234. Hepatic resection through an anterior approach employing a modified liver hanging maneuver in patients with a massive liver tumor severely oppressing the inferior vena cava Peer-reviewed

    M Suzuki, M Unno, Y Katayose, H Takeuchi, T Rikiyama, T Onogawa, T Sato, M Mizuma, H Ohtuka, S Mastuno

    HEPATO-GASTROENTEROLOGY　51　(59)　1459-1463　2004/09

    ISSN： 0172-6390

  2235. マルチスライスCTによる胆道癌診断 Peer-reviewed

    海野倫明, 片寄, 友, 力山敏樹, 山本久仁治, 石橋忠司, 松野

    肝胆膵　49　(3)　309-314　2004/09

  2236. 乳癌での有機アニオントランスポーターLST-2の発現と予後の相関 Peer-reviewed

    海野倫明, 溝井賢幸, 宮川菊雄

    逓信医学　56　(4)　269-270　2004/09

  2237. 肝癌 治癒切除不能肝内胆管癌に対するマイクロ波凝固療法の有用性の検討 Peer-reviewed

    深瀬耕二, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 水間正道, 松野正紀

    Journal of Microwave Surgery　22　91-94　2004/09

    Publisher:

    DOI： 10.3380/jmicrowavesurg.22.91 　

    ISSN： 0917-7728

  2238. 乳癌での有機アニオントランスポーターLST-2の発現と予後との相関 Peer-reviewed

    海野倫明, 溝井賢幸, 宮川菊雄

    逓信医学　56　(4)　269-270　2004/09

  2239. 肝門部胆管癌の外科治療戦略 Peer-reviewed

    海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 松野正紀

    日本消化器病学会雑誌　101　(臨増大会)　A844-A844　2004/09

  2240. 大腸癌肝転移のグリソン浸潤を考慮した系統的肝切除の意義 Peer-reviewed

    山本久仁治, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 小野川徹, 井伊貴幸, 松野正紀

    日本消化器病学会雑誌　101　(臨増大会)　A828-A828　2004/09

  2241. 胆道癌におけるLST-2の発現 Peer-reviewed

    井伊貴幸, 海野倫明, 片寄友, 力山敏樹, 小野川徹, 大塩博, 深瀬耕二, 松野正紀

    日本消化器病学会雑誌　101　(臨増大会)　A798-A798　2004/09

  2242. 胆汁酸発癌機構の解析 胆汁酸トランスポーターLST-2と核内レセプターPPARαを介したcyclooxygenase-2の誘導 Peer-reviewed

    大塩博, 海野倫明, 小野川徹, 井伊貴幸, 深瀬耕二, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 松野正紀

    日本消化器病学会雑誌　101　(臨増大会)　A776-A776　2004/09

  2243. 有機アニオントランスポーター遺伝子群の発見とその臨床応用 Peer-reviewed

    海野倫明, 阿部高明

    東北医学雑誌　116　(1)　37-41　2004/08

  2244. A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo Peer-reviewed

    T Abe, M Unno, H Takeuchi, T Kakita, Y Katayose, T Rikiyama, T Morikawa, M Suzuki, S Matsuno

    JOURNAL OF GASTROINTESTINAL SURGERY　8　(5)　604-615　2004/07

    DOI： 10.1016/j.gassur.2004.02.011 　

    ISSN： 1091-255X

  2245. 画像上多隔壁胆嚢との鑑別が困難であった胆嚢腺筋症の1例 Peer-reviewed

    武藤満完, 海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 松野正紀

    胆と膵　25　(7)　455-458　2004/07

  2246. A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells Peer-reviewed

    H Hayashi, R Asano, K Tsumoto, Y Katayose, M Suzuki, M Unno, H Kodama, S Takemura, H Yoshida, K Makabe, K Imai, S Matsuno, Kumagai, I, T Kudo

    CANCER IMMUNOLOGY IMMUNOTHERAPY　53　(6)　497-509　2004/06

    DOI： 10.1007/s00262-003-0465-9 　

    ISSN： 0340-7004

  2247. 【はじめての消化器外科手術】Hassab手術 Peer-reviewed

    力山敏樹, 海野倫明, 片寄 友, 松野正紀

    手術　58　(6)　1067-1071　2004/06

  2248. PANCREATIC ss-CELL REGENERATION BY Reg GENE AND Reg PROTEIN Peer-reviewed

    Okamoto Hiroshi, Takasawa Shin, Unno Michiaki, Nata Koji, Npguchi Naoya, Akiyama Takako, Ikeda Takayuki, Yakauchi Akiyo, Takahashi Iwao, Nakagawa Kei, Onogawa Tohru, Matsuno Seiki

    J Jpn Pancreas Soc　19　(3)　231-231　2004/04

  2249. 【肝病態生理研究のあゆみ】 癌細胞における胆汁酸トランスポーターの役割

    大塩博, 医学部消化器外科学分野, 海野倫明, 小野川徹, 大塚英郎, 井伊貴幸, 深瀬耕二, 武藤満完, 松野正紀, 阿部高明

    薬理と治療(0386-3603)　32　(Suppl.2)　S205-S206　2004/04

  2250. 胆汁酸トランスポーターの発現と転写調節機構，発癌・癌細胞増殖・浸潤への関与 Peer-reviewed

    小野川徹, 海野倫明

    厚生労働省難治性疾患克服研究事業分担研究報告書　.　(.)　85-89　2004/03

  2251. 胆汁酸はトランスポーターにより細胞内に輸送されcyclooxygenase-2を誘導する Peer-reviewed

    大塩博, 海野倫明, 小野川徹, 大塚英郎, 佐藤武揚, 井伊貴幸, 深瀬耕二, 阿部高明, 松野正紀

    日本消化器病学会雑誌　101　(臨増総会)　A183-A183　2004/03

  2252. 胆汁酸と細胞増殖,アポトーシス G蛋白共役型胆汁酸膜受容体を介した胆汁酸の新たな生理活性の探索 Peer-reviewed

    小野川徹, 海野倫明, 松野正紀

    日本消化器病学会雑誌　101　(臨増総会)　A120-A120　2004/03

  2253. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Peer-reviewed

    T Mikkaichi, T Suzuki, T Onogawa, M Tanemoto, H Mizutamari, M Okada, T Chaki, S Masuda, T Tokui, N Eto, M Abe, F Satoh, M Unno, T Hishinuma, K Inui, S Ito, J Goto, T Abe

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　101　(10)　3569-3574　2004/03

    DOI： 10.1073/pnas.0304987101 　

    ISSN： 0027-8424

  2254. Adenovirus expressing mutant p27(kip1) enhanced apoptosis against cholangiocarcinoma than adenovirus-p27(kip1) wild type

    T Sasaki, Y Katayose, M Suzuki, K Yamamoto, S Shiraso, M Mizuma, M Unno, H Takeuchi, CT Lee, S Matsuno

    HEPATO-GASTROENTEROLOGY　51　(55)　68-75　2004/01

    ISSN： 0172-6390

  2255. A Case Report of Guillain-Barre Syndrome Induced by Transcatheter Chemoembolization after Percutaneous Transhepatic Portal Embolization Analyzed by Cytokines Peer-reviewed

    Yu Katayose, Michiaki Unno, Toshiki Rikiyama, Tetsuya Kakita, Toru Onogawa, Satoru Shirasou, Masamichi Mizuma, Hideo Ohtsuka, Takeaki Sato, Seiki Matsuno

    Japanese Journal of Gastroenterological Surgery　37　(3)　301-306　2004

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.37.301 　

    ISSN： 0386-9768

  2256. Reg蛋白質-Reg受容体系の細胞増殖シグナル

    高沢 伸, 池田 崇之, 秋山 貴子, 川口 晶子, 山内 晶世, Shervani Nausheen J., 野口 直哉, 那谷 耕司, 海野 倫明, 小野川 徹, 岡本 宏

    生化学　75　(12)　1573-1573　2003/12

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  2257. Molecular characterization of human and rat organic anion transporter OATP-D Peer-reviewed

    Hisanobu Adachi, Takehiro Suzuki, Michiaki Abe, Naoki Asano, Hiroya Mizutamari, Masayuki Tanemoto, Toshiyuki Nishio, Tohru Onogawa, Takafumi Toyohara, Satoshi Kasai, Fumitoshi Satoh, Masanori Suzuki, Taro Tokui, Michiaki Unno, Tooru Shimosegawa, Seiki Matsuno, Sadayoshi Ito, Takaaki Abe

    American Journal of Physiology - Renal Physiology　285　(6)　F1188-F1197　2003/12

    ISSN： 0363-6127

  2258. Molecular characterization of human and rat organic anion transporter OATP-D Peer-reviewed

    H Adachi, T Suzuki, M Abe, N Asano, H Mizutamari, M Tanemoto, T Nishio, T Onogawa, T Toyohara, S Kasai, F Satoh, M Suzuki, T Tokui, M Unno, T Shimosegawa, S Matsuno, S Ito, T Abe

    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　285　(6)　F1188-F1197　2003/12

    DOI： 10.1152/ajprenal.00402.2002 　

    ISSN： 1931-857X

  2259. ヒト肝細胞におけるLiver-Specific Organic Anion Transporter ; LST-2 の転写調節機構 Peer-reviewed

    大塚英郎, 海野倫明, 片寄 友, 小野川徹, 大塩 博, 松野正紀

    薬理と治療　31　(supplement)　89-93　2003/12

  2260. 【肝病態生理研究のあゆみ】 ヒト肝細胞におけるLiver-Specific Organic Anion Transporter LST-2の転写調節機構 Peer-reviewed

    大塚英郎, 海野倫明, 片寄友, 力山敏樹, 小野川徹, 佐藤武揚, 大塩博, 松野正紀, 阿部高明

    薬理と治療　31　(Suppl.1)　S89-S93　2003/12

  2261. Adenovirus expressing p27(KIP1) induces apoptosis against cholangiocarcinoma cells by triggering Fas ligand on the cell surface Peer-reviewed

    K Yamamoto, Y Katayose, M Suzuki, M Unno, T Sasaki, M Mizuma, S Shiraso, H Ohtuka, KH Cowan, P Seth, S Matsuno

    HEPATO-GASTROENTEROLOGY　50　(54)　1847-1853　2003/11

    ISSN： 0172-6390

  2262. Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the rat eye Peer-reviewed

    A Ito, K Yamaguchi, H Tomita, T Suzuki, T Onogawa, T Sato, H Mizutamari, T Mikkaichi, T Nishio, T Suzuki, M Unno, H Sasano, T Abe, M Tamai

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　44　(11)　4877-4884　2003/11

    DOI： 10.1167/iovs.02-1108 　

    ISSN： 0146-0404

    eISSN： 1552-5783

  2263. 切除不能胆管癌に対するexpandable metallic biliary stenting治療の工夫 Peer-reviewed

    柿田徹也, 海野倫明, 片寄 友, 力山敏樹, 松野正紀

    外科　65　(10)　1177-1182　2003/10

  2264. 胆管癌の治療 1. 分子標的治療 Peer-reviewed

    海野倫明, 片寄, 友, 工藤俊雄, 松野正

    肝・胆・膵疾患の最新医療 戸田剛太郎他編 先端医療技術研究所　.　(.)　254-258　2003/10

  2265. 【胆嚢癌治療の基本方針】術前・術中診断の進歩と限界 胆嚢癌の進達度診断と手術方針 Peer-reviewed

    海野倫明, 松野正紀

    外科治療　65　(4)　377-380　2003/09

  2266. 新しい視点 特集：「胆汁酸トランスポーターの最新情報」肝胆道疾患における異常様相 Peer-reviewed

    海野倫明

    たんじゅうさん　2　(1)　12-13　2003/09

  2267. 肝疾患治療への免疫学の挑戦 上皮増殖因子受容体(EGFR)シグナルの抑制効果を合わせ持つ新規二重特異性抗体(diabody)を用いた養子免疫療法の種々の癌への応用 Peer-reviewed

    林洋毅, 海野倫明, 片寄友

    日本消化器病学会雑誌　100　(臨増大会)　A360-A360　2003/09

  2268. 膵胆道癌 早期診断の進歩 胆管癌診断におけるmultidetector-row CTの有用性 Peer-reviewed

    海野倫明, 松野正紀

    日本消化器病学会雑誌　100　(臨増大会)　A358-A358　2003/09

  2269. Identification and characterization of novel rat and human gonad-specific organic anion transporters Peer-reviewed

    T Suzuki, T Onogawa, N Asano, H Mizutamari, T Mikkaichi, M Tanemoto, M Abe, F Satoh, M Unno, K Nunoki, M Suzuki, T Hishinuma, J Goto, T Shimosegawa, S Matsuno, S Ito, T Abe

    MOLECULAR ENDOCRINOLOGY　17　(7)　1203-1215　2003/07

    DOI： 10.1210/me.2002-0304 　

    ISSN： 0888-8809

  2270. 直接膵浸潤が術前MPR-CT画像上確認された中・下部胆管癌の１切除例 Peer-reviewed

    大塩 博, 海野倫明, 力山敏樹, 柿田徹也, 水間正道, 白相, 松野正紀

    胆と膵　24　(6)　465-469　2003/06

  2271. 術前MDCTのMPR画像で直接膵浸潤が確認された中・下部胆管癌の1切除例 Peer-reviewed

    大塩博, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 柿田徹也, 小野川徹, 水間正道, 白相悟, 松野正紀

    胆と膵　24　(6)　465-469　2003/06

  2272. Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model Peer-reviewed

    H Ogawa, K Fukushima, H Naito, Y Funayama, M Unno, K Takahashi, T Kitayama, S Matsuno, H Ohtani, S Takasawa, H Okamoto, Sasaki, I

    INFLAMMATORY BOWEL DISEASES　9　(3)　162-170　2003/05

    DOI： 10.1097/00054725-200305000-00003 　

    ISSN： 1078-0998

  2273. ヒト肝疾患組織における性ホルモン受容体の免疫化学的検討 Peer-reviewed

    設楽英樹, 鈴木貴, 森谷卓也, 遠藤希之, 海野倫明, 鈴木正徳, 松野正紀, 笹野公伸

    日本病理学会会誌　92　(1)　337-337　2003/04

  2274. ヒト肝細胞における有機アニオントランスポーターLST-2の転写調節機構の解析 Peer-reviewed

    大塚英郎, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 小野川徹, 佐藤武揚, 大塩博, 松野正紀, 阿部高明

    日本消化器病学会雑誌　100　(臨増総会)　A228-A228　2003/03

  2275. 胆汁酸の腸肝循環におけるOATP-Eの腸管での発現,その病理形態学的解析またはOATP-E is expressed in human ileum enterocyte Peer-reviewed

    佐藤武揚, 海野倫明, 小野川徹, 大塚英郎, 大塩博, 竹内丙午, 片寄友, 松野正紀, 阿部高明

    日本消化器病学会雑誌　100　(臨増総会)　A192-A192　2003/03

  2276. Reg-Reg受容体系による膵β細胞の再生増殖とapoptosis HGF遺伝子の活性化によるapoptosisの防止

    中川 圭, 秋山 貴子, 池田 崇之, Shervani Nausheen J., 那谷 耕司, 井上 大輔, 野口 直哉, 海野 倫明, 松野 正紀, 高沢 伸, 岡本 宏

    Diabetes Frontier　14　(1)　108-109　2003/02

    Publisher: (株)メディカルレビュー社

    ISSN： 0915-6593

  2277. Expression of organic anion transporting polypeptide E (OATP-E) in human placenta. Peer-reviewed

    Sato K, Sugawara J, Sato T, Mizutamari H, Suzuki T, Ito A, Mikkaichi T, Onogawa T, Tanemoto M, Unno M, Abe T, Okamura K

    Placenta　24　(2-3)　144-148　2003/02

    ISSN： 0143-4004

  2278. A novel adenovirus expressing human 4-1BB ligand enhances antitumor immunity Peer-reviewed

    H Yoshida, Y Katayose, M Unno, M Suzuki, H Kodama, S Takemura, R Asano, H Hayashi, K Yamamoto, S Matsuno, T Kudo

    CANCER IMMUNOLOGY IMMUNOTHERAPY　52　(2)　97-106　2003/02

    DOI： 10.1007/s00262-002-0334-y 　

    ISSN： 0340-7004

  2279. ”剣山法”MCTを施行した直径12cmの巨大胆管細胞癌の治療経験 Peer-reviewed

    竹内丙午, 鈴木正徳, 海野倫明, 片寄, 友, 森川孝則, 松野正紀

    肝臓　44　(2)　71-75　2003/02

    DOI： 10.2957/kanzo.44.71 　

  2280. The Transcriptional Regulations of the Liver-Specific Organic Anion Transporter-2 in Hep3B Cell

    Hideo Ohtsuka, Michiaki Unno, Yu Katayose, Toshiki Rikiyama, Tohru Onogawa, Takeaki Sato, Hiroshi Oshio, Seiki Matsuno, Takaaki Abe

    Japanese Pharmacology and Therapeutics　31　(1)　S89-S107　2003

    ISSN： 0386-3603

  2281. Similarity and dissimilarity of LST-1/OATP2/OATP-C (SLC21A6) and OATP8/LST-2 (SLC21A8) Peer-reviewed

    Michiaki Unno, Takaaki Abe

    Journal of Gastroenterology　38　(1)　108-109　2003/01/01

    DOI： 10.1007/s005350300018 　

    ISSN： 0944-1174

  2282. 肝温虚血・再灌流障害における食細胞由来superxideの重要性〜NADPH oxidase 阻害剤 apocyninおよび塩化ガドリニウム投与からの検討 Peer-reviewed

    竹内丙午, 鈴木正徳, 森川孝則, 海野倫明, 片寄, 友, 松野正紀

    肝臓　44　(1)　13-19　2003/01

    DOI： 10.2957/kanzo.44.13 　

  2283. The role of NADPH oxidase in early phase warm ischemia-reperfusion injury of the liver Peer-reviewed

    Heigo Takeuchi, Masanori Suzuki, Takanori Morikawa, Tomoya Abe, Michiaki Unno, Yu Katayose, Seiki Matsuno

    Acta Hepatologica Japonica　44　(1)　13-19　2003

    Publisher: Japan Society of Hepatology

    DOI： 10.2957/kanzo.44.13 　

    ISSN： 0451-4203

  2284. A new method of microwave coagulonecrotic therapy applied to a patient with huge cholangiocellular carcinoma, a case report Peer-reviewed

    Heigo Takeuchi, Masanori Suzuki, Michiaki Unno, Yu Katayose, Takanori Morikawa, Masamichi Mizuma, Seiki Matsuno

    Acta Hepatologica Japonica　44　(2)　71-75　2003

    Publisher: Japan Society of Hepatology

    DOI： 10.2957/kanzo.44.71 　

    ISSN： 0451-4203

  2285. Inhibition of heme oxygenase ameliorates sepsis-induced liver dysfunction in rats Peer-reviewed

    H Iwasashi, M Suzuki, M Unno, T Utiyama, M Oikawa, N Kondo, S Matsuno

    SURGERY TODAY　33　(1)　30-38　2003

    DOI： 10.1007/s005950300005 　

    ISSN： 0941-1291

  2286. 遺伝子改変動物を用いたインスリン産生細胞増殖因子Regの機能解析

    野口 直哉, 那谷 耕司, 海野 倫明, 中川 圭, 池田 崇之, 秋山 貴子, Shervani Nausheen J., 井上 大輔, 川口 晶子, 小野川 徹, 高沢 伸, 岡本 宏

    生化学　74　(12)　1492-1492　2002/12

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  2287. Production and characterization of Reg knockout mice - Reduced proliferation of pancreatic beta-cells in Reg knockout mice Peer-reviewed

    M Unno, K Nata, N Noguchi, Y Narushima, T Akiyama, T Ikeda, K Nakagawa, S Takasawa, H Okamoto

    DIABETES　51　S478-S483　2002/12

    ISSN： 0012-1797

  2288. 肝外発育傾向が著明で術前診断に苦慮した多発性肝嚢胞腺癌の一切除例 Peer-reviewed

    白相 悟, 海野倫明, 片寄, 力山敏樹, 松野正紀, 遠藤

    消化器画像　4　(.)　727-734　2002/11

    DOI： 10.11477/mf.1427900474 　

  2289. 肝外発育傾向が著明で術前診断に苦慮した多発性肝嚢胞腺癌の1切除例 Peer-reviewed

    白相悟, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 松野正紀, 遠藤希之

    消化器画像　4　(6)　727-734　2002/11

    DOI： 10.11477/mf.1427900474 　

  2290. 腹側膵が門脈を輪状に巻き込み膵体部と癒合した、いわゆる"portal annular pancreas" の１例． Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄 友, 力山敏樹, 竹内丙午, 白相 悟 松野正紀

    胆と膵　22　(11)　963-966　2002/11

  2291. 2)変異型スーパー抗原・バイスペシフィック抗体融合蛋白による新型養子免疫療法の確立─切除不能胆管癌を標的とする遺伝子工学的手法を導入した各種治療薬の開発─ Peer-reviewed

    鈴木正徳, 竹村真一, 海野倫明, 片寄 友, 松野正紀

    成人病と生活習慣病　32　(10)　1334-1340　2002/10

  2292. 下大静脈高度圧迫を伴う巨大肝腫瘍症例に対する hanging maneuverを用いた前方アプローチによる肝切除術 Peer-reviewed

    鈴木正徳, 海野倫明, 片寄 友, 力, 竹内丙午, 松野

    手術　56　(11)　1763-1768　2002/10

  2293. 開腹下MCTは肝部下大静脈に接する大型肝細胞癌に対しても奏功する Peer-reviewed

    及川昌也, 鈴木正徳, 海野倫明, 片寄 友, 松野正紀

    J Microwave Surg　18　79-85　2002/10

  2294. 変異型スーパー抗原・バイスペシフィック抗体融合蛋白による新型養子免疫療法の確立 切除不能胆管癌を標的とする遺伝子工学的手法を導入した各種治療薬の開発 Peer-reviewed

    鈴木正徳, 竹村真一, 海野倫明, 遠藤公人, 片寄友, 松野正紀

    成人病と生活習慣病　32　(10)　1334-1340　2002/10

  2295. 肝細胞癌に対する開腹下マイクロウェーブ凝固壊死療法（open MCT）の治療成績 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄, 力山敏樹, 森川孝則, 松野正紀

    Jounal of Microwave Surgery　.　(20)　57-59　2002/09

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.20.57 　

    ISSN： 0917-7728

    More details Close

    We now evaluated our therapeutic outcomes of open microwave coagulo-necrotic therapy (MCT) for hepatocellular carcinoma (HCC). The subjects were 23 patients for whom we underwent open MCT from November 1992 to December 2000. Postoperative three-year survival rate in Stage III cases for which open MCT was performed was 45.5%. In a comparison of the cumulative survival rates, there is no significant difference between the cases of the open MCT and hepatic resection. Local recurrence of treated area was experienced in only one case. This result suggested that open MCT is good for local ablation therapy for HCC. However, we actually experienced the lethal complications such as hepatic failure and pyothorax. We must be careful for extending the indication of open MCT.

  2296. 肝細胞癌に対する開腹下マイクロウェーブ凝固壊死療法(open MCT)の治療成績 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 森川孝則, 及川昌也, 松野正紀

    Journal of Microwave Surgery　20　57-59　2002/09

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.20.57 　

    ISSN： 0917-7728

    More details Close

    We now evaluated our therapeutic outcomes of open microwave coagulo-necrotic therapy (MCT) for hepatocellular carcinoma (HCC). The subjects were 23 patients for whom we underwent open MCT from November 1992 to December 2000. Postoperative three-year survival rate in Stage III cases for which open MCT was performed was 45.5%. In a comparison of the cumulative survival rates, there is no significant difference between the cases of the open MCT and hepatic resection. Local recurrence of treated area was experienced in only one case. This result suggested that open MCT is good for local ablation therapy for HCC. However, we actually experienced the lethal complications such as hepatic failure and pyothorax. We must be careful for extending the indication of open MCT.

  2297. [S4 S5 subsegmentectomy of the liver for gallbladder carcinoma] Peer-reviewed

    Unno Michiaki, Suzuki Masanori, Katayose Yu, Takeuchi Heigo, Rikiyama Toshiki, Matsuno Seiki

    Nippon Geka Gakkai Zasshi　103　(8)　543-548　2002/08

  2298. 肝切除を伴う外科治療の適応 Peer-reviewed

    小野川徹, 鈴木正徳, 海野倫明, 片寄, 竹内丙午, 松野

    肝胆膵　45　(2)　269-273　2002/08

  2299. 胆嚢癌に対する拡大胆嚢摘出術 Peer-reviewed

    海野倫明, 鈴木正徳, 松野正紀

    手術　56　(9)　1304-1310　2002/08

  2300. 胆嚢癌に対するS4下S5切除─適応と手術の要点 Peer-reviewed

    海野倫明, 鈴木正徳, 片寄 友, 竹, 力山敏樹, 松野

    日外会誌　103　(8)　543-548　2002/08

  2301. Thyroid hormone transporters: recent advances Peer-reviewed

    T Abe, T Suzuki, M Unno, T Tokui, S Ito

    TRENDS IN ENDOCRINOLOGY AND METABOLISM　13　(5)　215-220　2002/07

    DOI： 10.1016/S1043-2760(02)00599-4 　

    ISSN： 1043-2760

  2302. 肝臓外科周術期管理におけるドレーンパウチ法の有用性 Peer-reviewed

    大塚英郎, 鈴木正徳, 海野倫明, 片寄, 竹内丙午, 松野

    日消外会誌　35　(6)　575-581　2002/06

    DOI： 10.5833/jjgs.35.575 　

  2303. 専門医療施設における鑑別診断─CT検査─． Peer-reviewed

    海野倫明, 山本久仁治, 鈴木正徳, 松野正紀

    消化器の臨床　4　(6)　714-718　2002/06

  2304. 吸収性テープやLiver Hanging Maneuver を応用した肝離断 Peer-reviewed

    鈴木正徳, 海野倫明, 力山敏樹, 片寄, 竹内丙午, 大塚英郎, 松野

    外科　64　(5)　558-565　2002/05

  2305. 粘膜に限局する乳頭型肝門部胆管癌治癒切除術後遠隔期に生じた肝腫瘍の１切除例 Peer-reviewed

    阿部友哉, 鈴木正徳, 海野倫明, 片寄, 力山敏樹, 水間正道, 遠藤希之

    胆道　16　(2)　125-131　2002/05

    DOI： 10.11210/tando1987.16.2_125 　

  2306. 粘膜に限局する乳頭型肝門部胆管癌治癒切除術後遠隔期に生じた肝腫瘍の1切除例 Peer-reviewed

    阿部友哉, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 水間正道, 松野正紀, 遠藤希之

    胆道　16　(2)　125-131　2002/05

    DOI： 10.11210/tando1987.16.2_125 　

  2307. 肝細胞癌に対する経皮的ラジオ波熱焼灼療法(PRFA)の治療効果の検討 Peer-reviewed

    林洋毅, 鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 竹内丙午, 松野正紀

    癌の臨床　48　(4)　223-228　2002/05

    Publisher:

    ISSN： 0021-4949

  2308. 術前に診断が可能であった上部胆管腺扁平上皮癌の１切除例． Peer-reviewed

    大塚英郎, 鈴木正徳, 海野倫明, 片寄 友, 竹内丙午, 佐藤武揚, 渡辺みか, 松野正紀

    胆道　15　(5)　399-405　2002/05

    DOI： 10.11210/tando1987.15.5_399 　

  2309. Reg-Reg受容体系によるβ細胞cyclin D1遺伝子の活性化

    高沢 伸, 池田 崇之, 中川 圭, 秋山 貴子, Shervani Nausheen J., 井上 大輔, 川口 晶子, 野口 直哉, 那谷 耕司, 海野 倫明, 松野 正紀, 岡本 宏

    糖尿病　45　(Suppl.2)　S169-S169　2002/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  2310. 止血用動物性微線維性コラーゲンに起因する炎症性腫瘤による良性胆管狭窄の１例 Peer-reviewed

    白相 悟, 鈴, 海野倫明, 片寄, 力山敏樹, 松野正紀

    日臨外会誌　63　(4)　989-993　2002/04

    DOI： 10.3919/jjsa.63.989 　

  2311. 肝細胞癌に対する経皮的ラジオ波熱焼灼療法（PRFA）の治療効果の検討 Peer-reviewed

    林 洋毅, 海野倫明, 片寄 友, 竹内丙, 松野正紀

    癌の臨床　48　(4)　223-228　2002/04

    Publisher:

    ISSN： 0021-4949

  2312. 止血用動物性微線維性コラーゲンに起因する炎症性腫瘤による良性胆管狭窄の1例 Peer-reviewed

    白相悟, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 松野正紀

    日本臨床外科学会雑誌　63　(4)　989-993　2002/04

    DOI： 10.3919/jjsa.63.989 　

  2313. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina Peer-reviewed

    A Ito, K Yamaguchi, T Onogawa, M Unno, T Suzuki, T Nishio, T Suzuki, H Sasano, T Abe, M Tamai

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　43　(3)　858-863　2002/03

    ISSN： 0146-0404

  2314. 経過観察中に急速な増大を来した肝血管筋脂肪腫の１例 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄, 友, 白相 悟, 松野正, 森谷卓也

    肝臓　43　(3)　144-149　2002/03

    DOI： 10.2957/kanzo.43.144 　

  2315. ラット腸管に発現する2種の有機アニオントランスポーターの解析 Peer-reviewed

    佐藤武揚, 海野倫明, 小野川徹, 大塚英郎, 浅野直喜, 阿部高明, 鈴木正徳, 松野正紀

    日本消化器病学会雑誌　99　(臨増総会)　A264-A264　2002/03

  2316. アデノウイルス発現系によるヒト肝特異的有機アニオントランスポーターの機能解析 Peer-reviewed

    安達尚宣, 海野倫明, 阿部高明, 小野川徹, 藤原耕, 安藤敏典, 大塚英郎, 片寄友, 鈴木正徳, 松野正紀

    日本消化器病学会雑誌　99　(臨増総会)　A241-A241　2002/03

  2317. ヒト肝臓特異的有機アニオントランスポーターLST-2の消化器癌での発現と転写調節機構の解析 Peer-reviewed

    大塚英郎, 小野川徹, 海野倫明, 阿部高明, 佐藤武揚, 浅野直喜, 近藤典子, 鈴木正徳, 松野正紀

    日本消化器病学会雑誌　99　(臨増総会)　A240-A240　2002/03

  2318. 消化器疾患と胆汁酸研究 今後の展開 肝臓・消化器癌における有機アニオントランスポーターの発現と機能 Peer-reviewed

    海野倫明, 阿部高明, 鈴木正徳

    日本消化器病学会雑誌　99　(臨増総会)　A56-A56　2002/03

  2319. 胆汁酸の腸肝循環を担う有機アニオントランスポーターの発現と機能 Peer-reviewed

    海野倫明, 藤原, 耕, 佐藤武揚, 安達尚宣, 小野川徹, 松野正紀

    消化と吸収　24　(1)　52-57　2002/02

  2320. 胆管癌に対するDouble angled pre-shaped sheathを用いた高線量率192Ir線源による胆管腔内放射線照射療法 Peer-reviewed

    鈴木正徳, 大塚英郎, 海野倫明, 片寄, 竹内丙午, 佐藤武揚, 有賀久哲, 松野

    胆と膵　23　(2)　135-140　2002/02

  2321. 膵鈎状突起が上腸間膜静脈を輪状に巻き込み膵体部と癒合したportal annular pancreas 一例〜幽門温存膵頭十二指腸切除術を併施した胆嚢癌切除の経験から〜． Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄, 竹内丙午, 松野

    臨床解剖研究会記録2002　2　(.)　38-39　2002/02

  2322. Changes of hepatic sinusoids in experimental septicemia of rats are correlated with the production of nitrogen monoxide. A morphometrical and immunohistochemical study Peer-reviewed

    K Endo, M Suzuki, T Takahashi, M Unno, H Iwasashi, T Sasaki, S Matsuno

    HEPATO-GASTROENTEROLOGY　49　(43)　136-143　2002/01

    ISSN： 0172-6390

  2323. 外因性液状フィブリングルー製剤の事前調整の可能性に関する実験的検討 Peer-reviewed

    鈴木正徳, 小野川徹, 海野倫明, 片寄 友, 竹, 及川昌也, 松野正紀

    日消外会誌　35　(1)　18-23　2002/01

    DOI： 10.5833/jjgs.35.18 　

  2324. 食道静脈瘤の発生を契機に発見された先天性上大静脈欠損症の一成人例． Peer-reviewed

    近藤典子, 鈴木正徳, 海野倫明, 児玉英謙, 岩指, 小野川徹, 松野

    外科治療　64　(1)　106-111　2002/01

  2325. Possibility of pre-adjusting exogenous liquid fibrin glue prior to the surgical operation Peer-reviewed

    Masanori Suzuki, Tohru Onogawa, Michiaki Unno, Kojin Endo, Yu Katayose, Heigo Takeuchi, Masaya Oikawa, Noriko Kondo, Seiki Matsuno

    Japanese Journal of Gastroenterological Surgery　35　(1)　18-23　2002

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.35.18 　

    ISSN： 0386-9768

  2326. 胆汁酸の腸肝循環を担う有機アニオントランスポーターの発現と機能 Peer-reviewed

    海野倫明, 藤原 耕, 佐藤武揚, 大塚英郎, 安達尚宣, 近藤典子, 小野川徹, 鈴木正徳, 松野正紀

    消化と吸収　24　(1)　52-57　2002/01

  2327. 食道静脈瘤の発生を契機に発見された先天性上大静脈欠損症の一成人例． Peer-reviewed

    近藤典子, 鈴木正徳, 海野倫明, 遠藤公人, 児玉英謙, 岩指 元, 小野川徹, 松野正紀

    外科　64　(1)　106-111　2002/01

  2328. 膵鈎状突起が上腸間膜静脈を輪状に巻き込み膵体部と癒合したportal annular pancreas 一例〜幽門温存膵頭十二指腸切除術を併施した胆嚢癌切除の経験から〜． Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄 友, 竹内丙午, 松野正紀

    臨床解剖研究会記録2002　2　38-39　2002/01

  2329. A case of hepatic angiomyolipoma with rapid growth in follow-up Peer-reviewed

    Masamichi Mizuma, Masanori Suzuki, Michiaki Unno, Yu Katayose, Heigo Takeuchi, Satoru Shiraso, Seiki Matsuno, Takuya Moriya

    Acta Hepatologica Japonica　43　(3)　144-149　2002

    Publisher: Japan Society of Hepatology

    DOI： 10.2957/kanzo.43.144 　

    ISSN： 0451-4203

  2330. Significance of xanthine oxidase in the production of intracellular oxygen radicals in an in-vitro hypoxia-reoxygenation model Peer-reviewed

    Tetsuya Kakita, Masanori Suzuki, Heigo Takeuchi, Michiaki Unno, Seiki Matsuno

    Journal of Hepato-Biliary-Pancreatic Surgery　9　(2)　249-255　2002

    DOI： 10.1007/s005340200027 　

    ISSN： 0944-1166

  2331. Benefit of the drain pauch method in the postoperative management of the hepatic surgery Peer-reviewed

    Hideo Ohtsuka, Masanori Suzuki, Michiaki Unno, Yu Katayose, Heigo Takeuchi, Seiki Matsuno

    Japanese Journal of Gastroenterological Surgery　35　(6)　575-581　2002

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.35.575 　

    ISSN： 0386-9768

  2332. 胆汁酸トランスポーター機構の変化 ─LST/OATPファミリーの機能と転写調節─ Peer-reviewed

    海野倫明, 近藤典子, 阿部高明, 藤原 耕, 安, 鈴木正徳, 松野

    肝胆膵　43　(6)　1021-1027　2001/12

  2333. 術前に診断が可能であった上部胆管腺扁平上皮癌の１切除例． Peer-reviewed

    大塚英郎, 鈴木正徳, 海野倫明, 片寄, 竹内丙午, 渡辺みか 松野正紀

    胆道　15　(5)　399-405　2001/12

    DOI： 10.11210/tando1987.15.5_399 　

  2334. 術前に診断が可能であった上部胆管腺扁平上皮癌の1切除例 Peer-reviewed

    大塚英郎, 鈴木正徳, 海野倫明, 片寄友, 竹内丙午, 佐藤武揚, 水間正道, 渡辺みか, 松野正紀

    胆道　15　(5)　399-405　2001/12

    DOI： 10.11210/tando1987.15.5_399 　

  2335. 組織接着閉鎖剤の種類と特徴 Peer-reviewed

    鈴木正徳, 海野倫明, 片寄 友, 竹, 小野川徹, 及川昌也, 松野

    Surgery frontier　8　(4)　100-104　2001/11

  2336. 腹側膵が門脈を輪状に巻き込み膵体部と癒合した、いわゆる"portal annular pancreas" の１例． Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄, 力山敏樹, 白相 悟, 松野正紀

    胆と膵　22　(11)　963-966　2001/11

  2337. 腹側膵が門脈を輪状に巻き込み膵体部と癒合した,いわゆる"portal annular pancreas"の1例 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄友, 力山敏樹, 竹内丙午, 白相悟, 松野正紀

    胆と膵　22　(11)　963-966　2001/11

  2338. Reg蛋白受容体の構造と機能

    小林 誠一, 秋山 貴子, 那谷 耕司, Shervani Nausheen J., 池田 崇之, 中川 圭, 加藤 一郎, 海野 倫明, 松野 正紀, 佐々木 英忠

    Diabetes Frontier　12　(5)　660-660　2001/10

    Publisher: (株)メディカルレビュー社

    ISSN： 0915-6593

  2339. 専門医療施設における鑑別診断─CT検査─ Peer-reviewed

    海野倫明, 山本久仁治, 鈴木正徳, 松野正紀

    消化器の臨床　4　(6)　714-718　2001/10

  2340. 肝部下大静脈に隣接した転移性肝腫瘍に対して,流入流出路血行遮断下,中肝静脈経由でopen MCTを施行して有効であった1症例 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄友, 遠藤公人, 及川昌也, 山本久仁治, 松野正紀, 鈴木幸正

    Journal of Microwave Surgery　19　89-92　2001/10

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.19.89 　

    ISSN： 0917-7728

    More details Close

    We experienced a patient who underwent open MCT with the needle advanced via the middle hepatic vein for a metastatic liver tumor neighboring the paracaval portion. Open MCT was performed under hepatic inflow and outflow block to reduce the cooling effect by the blood flow. The operation was uneventfully performed, and no complications such as massive hemorrhage from middle hepatic vein, pulmonary infarction nor congestion in the drainage area of middle hepatic vein occurred. There was no evidence of local recurrence and other intrahepatic or extrahepatic metastases within 11 months after the operation. In conclusion, open MCT under hepatic inflow and outflow block is effective for tumors adjacent to a major hepatic vein. There was no complication when open MCT was performed by penetrating a major hepatic vein.

  2341. 臓器機能再生と再建のための手術：門脈修復 Peer-reviewed

    片寄 友, 鈴木正徳, 海野倫明, 松野正紀

    手術　55　(8)　1215-1221　2001/09

  2342. 膵β細胞でReg遺伝子を過剰発現するNODマウスでは糖尿病発症が抑制される

    那谷 耕司, 加藤 一郎, 野口 直哉, 吉川 雄朗, 井上 大輔, 海野 倫明, 松野 正紀, 高澤 伸, 岡本 宏

    生化学　73　(8)　1012-1012　2001/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  2343. 高線量率192Ir線源専用新規アプリケーターを用いた切除不能肝外胆管癌に対する低侵襲性chemoradiation 併用胆道 stenting Peer-reviewed

    鈴木正徳, 佐藤武揚, 海野倫明, 片寄, 竹内丙午, 小野川徹, 林, 松野正紀, 松下

    胆と膵　22　(8)　683-689　2001/08

  2344. 新しい有機アニオントランスポーターLST-2は消化器癌に異所性に発現しMTX感受性を担う Peer-reviewed

    小野川徹, 海野倫明, 近藤典子, 藤原 耕, 大谷明夫, 名倉 宏, 阿部高, 松野正紀

    東北医誌　113　(1)　91-93　2001/08

  2345. 高線量率192Ir線源専用新規アプリケーターを用いた切除不能肝外胆管癌に対する低侵襲性chemoradiation併用胆道stenting Peer-reviewed

    鈴木正徳, 佐藤武揚, 海野倫明, 片寄友, 竹内丙午, 及川昌也, 小野川徹, 林洋毅, 松野正紀, 松下晴雄

    胆と膵　22　(8)　683-689　2001/08

  2346. 門脈損傷時の門脈修復の実際 Peer-reviewed

    片寄 友, 鈴木正徳, 海野倫明, 松野正紀

    手術　55　(8)　1215-1221　2001/07

  2347. 有機アニオントランスポーターoatp/LSTとその機能 Peer-reviewed

    阿部高明, 海野倫明, 小野川徹, 徳井太郎

    蛋白質・核酸・酵素　46　(5)　612-620　2001/05

  2348. 肝部下大静脈に隣接した転移性肝腫瘍に対して、流入流出路結構遮断下、中肝静脈経由でopen MCTを施行して有効であった一症例 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄, 遠藤公人, 山本久仁治, 鈴木幸正

    J Microwave Surg　19　(.)　89-92　2001/05

  2349. Enhancement of Reg-induced beta-cell regeneration by hepatocyte growth factor. Peer-reviewed

    Okamoto H, Nakagawa J, Akiyama T, Nata K, Kobayashi S, Shervani N. J, Ikeda T, Noguchi N, Kato I, Unno M, Matsuno S, Takasawa S

    Diabetes　50　A336-A336　2001/04

  2350. Reg遺伝子の過剰発現によるNODマウスの糖尿病発症抑制

    那谷 耕司, 秋山 貴子, 小林 誠一, 野口 直哉, 加藤 一郎, 海野 倫明, 松野 正紀, 高澤 伸, 岡本 宏

    糖尿病　44　(Suppl.1)　S90-S90　2001/03

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  2351. 胎児肝,胆道閉鎖症でのLST(liver specific transporter)1及び2の発現についての検討 Peer-reviewed

    佐々木英之, 鈴木貴, 阿部高明, 海野倫明, 大井龍司, 笹野公伸

    日本病理学会会誌　90　(1)　285-285　2001/03

  2352. 胆道メタリックステンティングの問題点と対策 放射線化学療法併用と胆道ステンティング Peer-reviewed

    鈴木正徳, 海野倫明, 片寄 友, 竹, 及川昌也, 林 洋毅, 松野正紀

    胆と膵　22　(3)　255-259　2001/03

  2353. Reg蛋白レセプター Peer-reviewed

    海野倫明, 小林誠一, 高沢 伸, 松野正紀, 岡本 宏

    分子糖尿病─基礎から臨床まで2001─　.　(.)　165-169　2001/03

  2354. インターフェロン著効後、約６年の経過で発症した肝細胞癌の１例 Peer-reviewed

    坂田直昭, 鈴木正徳, 海野倫明, 松野正紀, 遠藤

    日臨外会誌　63　(3)　761-766　2001/03

    DOI： 10.3919/jjsa.62.761 　

  2355. インターフェロン著効後,約6年の経過で発症した肝細胞癌の1例 Peer-reviewed

    坂田直昭, 鈴木正徳, 海野倫明, 及川昌也, 松野正紀, 遠藤希之

    日本臨床外科学会雑誌　62　(3)　761-766　2001/03

    DOI： 10.3919/jjsa.62.761 　

  2356. 肝門部胆管癌に対する腫瘍形態に応じた治療法選択の可能性について Peer-reviewed

    鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 竹内丙午, 竹村真一, 及川昌也, 松野正紀

    胆道　15　(1)　25-34　2001/03

    DOI： 10.11210/tando1987.15.1_25 　

  2357. インスリン産生細胞増殖因子Reg受容体の構造・発現・機能

    小林 誠, 秋山 貴子, 那谷 耕司, Shervani Nausheen J., 池田 崇之, 許 立慶, 中川 圭, 野口 直哉, 海野 倫明, 松野 正樹

    生化学　73　(2)　132-132　2001/02

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  2358. 下血を主訴として発見された Meckel 憩室腫瘍の１例 Peer-reviewed

    坂田直昭, 鈴木正徳, 海野倫明, 松野正紀, 大谷

    日臨外会誌　62　(2)　415-420　2001/02

    DOI： 10.3919/jjsa.62.415 　

    ISSN： 1345-2843

  2359. 3. 肝膵同時切除術後の肝非実質細胞を介した肝再生抑制機構 〜ラット肝・膵同時切除モデルを用いた実験的検討〜 Peer-reviewed

    鈴木正徳, 力山敏樹, 海野倫明, 及川昌也, 松野

    日外会誌　102　(2)　203-209　2001/02

  2360. 肝特異的トランスポーター蛋白を用いた人工脂質二重膜による無細胞人工肝臓の開発 Peer-reviewed

    海野倫明

    東北医誌　112　180-182　2001/02

  2361. Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Peer-reviewed

    Akiyama T, Takasawa S, Nata K, Kobayashi S, Abe M, Shervani N J, Ikeda T, Nakagawa K, Unno M, Matsuno S, Okamoto H

    Proc Natl Acad Sci U S A　98　(1)　48-53　2001/01/02

    DOI： 10.1073/pnas.240458597 　

  2362. Interleukin-10 induction after combined resection of liver and pancreas Peer-reviewed

    T. Uchiyama, M. Suzuki, M. Unno, T. Rikiyama, M. Oikawa, S. Matsuno

    Hepato-Gastroenterology　48　(42)　1705-1710　2001

    ISSN： 0172-6390

  2363. Hemodynamic patterns of phosphatidylcholine hydroperoxide and hyaluronic acid during hepatic ischemia-reperfusion Peer-reviewed

    Masanori Suzuki, Takayuki Yamaki, Heigo Takeuchi, Michiaki Unno, Yu Katayose, Tetsuya Kakita, Mohammad Masihur Rahman, Seiki Matsuno

    Journal of Hepato-Biliary-Pancreatic Surgery　8　(2)　161-168　2001

    DOI： 10.1007/s005340170041 　

    ISSN： 0944-1166

  2364. 腸管に発現する有機アニオントランスポーターの単離と機能解析 Peer-reviewed

    海野倫明, 小野川徹, 藤原 耕, 安, 近藤典子, 鈴木正徳, 阿部高明, 徳井

    消化と吸収　23　(1)　32-36　2001/01

    ISSN： 0389-3626

  2365. 食道静脈瘤の発生を契機に発見された先天性上大静脈欠損の1成人例 Peer-reviewed

    近藤典子, 鈴木正徳, 海野倫明, 遠藤公人, 児玉英謙, 岩指元, 小野川徹, 松野正紀

    外科　64　(1)　106-111　2001/01

  2366. アルコール性肝硬変に合併した小腸静脈瘤破裂出血に対してTIPSが奏効した1例 Peer-reviewed

    佐々木剛, 鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 松野正紀, 小熊徹彦, 菊池淳

    日本門脈圧亢進症学会雑誌　6　(3)　161-165　2000/11

    DOI： 10.11423/jsph1999.6.3_161 　

  2367. The involvement of the intracellular superoxide production system in hepatic ischemia-reperfusion injuryIn vivo and in vitro experiments using transgenic mice manifesting excessive CuZn-SOD activity Peer-reviewed

    Masanori Suzuki, Heigo Takeuchi, Tetsuya Kakita, Michiaki Unno, Yu Katayose, Seiki Matsuno

    Free Radical Biology and Medicine　29　(8)　756-763　2000/10/15

    DOI： 10.1016/S0891-5849(00)00369-5 　

    ISSN： 0891-5849

  2368. アルコール性肝硬変に合併した小腸静脈瘤破裂出血に対してTIPSが奏功した１例 Peer-reviewed

    佐々木剛, 鈴木正徳, 海野倫明, 片寄 友, 松野正紀, 菊池 淳

    日門亢会誌　6　(.)　161-165　2000/10

    DOI： 10.11423/jsph1999.6.3_161 　

  2369. 開腹下MCTは肝部下大静脈に接する大型肝細胞癌に対しても奏効する Peer-reviewed

    及川昌也, 鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 松野正紀

    Journal of Microwave Surgery　18　79-85　2000/10

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.18.79 　

    ISSN： 0917-7728

    More details Close

    Microwave coagulo-necrotic therapy (MCT) have been realised ablation of hepatic tumor ensuring the tumor free margin without taking too many risks. It is the feature of MCT distinguished from any other minimal invasive therapy, including percutaneous ethanol injection therapy (PEIT) and transarterial chemoembolization (TACE) for hepatocellular carcinoma. But the lesions adjacent to the inferior vena cava (IVC) or the hepatic hilar portion are thought to be not good candidates for MCT on account of injuring these structures in ease.<br>We report a treated case of HCC adjacent to the IVC. Initially, TACE applied because of poor hepatic functional reserve, but TACE showed an insufficient effect, and MCT underwent secondary. After laparotomy, we performed 63 times punctures of the needle and coagulation to the tumor, and accomplished complete ablation to the tumor just front of the IVC. After 2 months from the open MCT, the lesions were enclosed within the coagulating area and no carcinoma recurence has been found for 2 years after these procedures.<br>This result from the case demonstrates that the MCT for the lesions neighboring the paracaval portion of the liver is one of useful procedures within the multidiscipliary approach to the hepatocellular caricinoma.

  2370. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Peer-reviewed

    Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, Nakai D, Shiiba K, Suzuki M, Ohtani H, Kondo Y, Unno M, Ito S, Iinuma K, Nunoki K, Matsuno S, Abe T

    Biochem Biophys Res Commun　275　(3)　831-838　2000/09/07

    DOI： 10.1006/bbrc.2000.3377 　

  2371. 肝動注癌化学療法後肝切除を施行した大腸癌肝転移症例の検討 Peer-reviewed

    吉田 寛, 鈴, 海野倫明, 小笠原鉄郎, 山崎日

    日消誌　97　(10)　1252-1260　2000/09

    DOI： 10.11405/nisshoshi1964.97.1252 　

  2372. 外科的立場からみた切除不能肝管・上中部胆管癌に対する集学的治療 Peer-reviewed

    鈴木正徳, 海野倫明, 遠藤公人, 片寄, 及川昌也, 林, 柿田徹也, 松野

    消化器外科　23　(9)　1447-1454　2000/08

  2373. 遠隔成績からみた多発肝細胞癌に対する肝切除の臨床的意義 Peer-reviewed

    鈴木正徳, 藤原, 耕, 海野倫明, 片寄 友, 森, 近藤典子, 松野

    消化器科　30　(5)　634-640　2000/05

  2374. 自己拡張性金属製ステントによる胆管内瘻化の過程で胆管破裂を認めた切除不能肝門部胆管癌の１症例 Peer-reviewed

    中川 圭, 海野倫明, 遠藤公人, 片寄, 柿田徹也, 松

    胆と膵　21　(5)　403-407　2000/05

  2375. 胆道の腫瘍性疾患 胆管癌 Peer-reviewed

    片寄 友, 鈴木正徳, 海野倫明, 松野正紀

    外科治療　82　(増刊)　261-266　2000/05

  2376. 肝臓の胆汁酸トランスポーターとその機能 Peer-reviewed

    海野倫明, 阿部高明, 鈴木正徳, 松野正紀

    肝胆膵　41　(5)　727-735　2000/05

  2377. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. Peer-reviewed

    Kobayashi S, Akiyama T, Nata K, Abe M, Tajima M, Shervani N J, Unno M, Matsuno S, Sasaki H, Takasawa S, Okamoto H

    J Biol Chem　275　(15)　10723-10726　2000/04/14

    DOI： 10.1074/jbc.275.15.10723 　

  2378. 予後から見たss胆嚢癌に対する適正手術 Peer-reviewed

    海野倫明, 鈴木正徳, 松野正紀

    消化器科　30　(4)　525-530　2000/04

  2379. 耐性菌感染症とその緊急具体策：対策編 Peer-reviewed

    遠藤公人, 鈴木正徳, 海野倫明, 片寄, 友, 松野正紀

    化学療法の領域　16　(S-2)　250-255　2000/04

  2380. 乳頭炎と胆道内圧 ─胆道内圧からみた乳頭狭窄と乳頭不全─ Peer-reviewed

    海野倫明, 内藤, 剛, 鈴木正徳, 松野正

    胆と膵　21　(2)　115-118　2000/02

  2381. 食道胃静脈瘤に対する Hassab 手術の手技簡略化および侵襲軽減の試み Peer-reviewed

    鈴木正徳, 岩指, 元, 海野倫明, 片寄 友, 近藤典子, 吉田, 佐々木巌, 松

    手術　54　(2)　217-221　2000/02

  2382. Detection of perfusion areas of the gallbladder vein on computed tomography during arterial portography (CTAP) - The background for dual S(4a) · S5 hepatic subsegmentectomy in advanced gallbladder carcinoma Peer-reviewed

    Masanori Suzuki, Kuniharu Yamamoto, Michiaki Unno, Yu Katayose, Kojin Endo, Masaya Oikawa, Seiki Matsuno

    Hepato-Gastroenterology　47　(33)　631-635　2000

    ISSN： 0172-6390

  2383. Surgical treatment and postoperative outcomes for middle and lower bile duct carcinoma in Japan - Experience of a single institute Peer-reviewed

    Masanori Suzuki, Michiaki Unno, Masaya Oikawa, Kojin Endo, Yu Katayose, Seiki Matsuno

    Hepato-Gastroenterology　47　(33)　650-657　2000

    ISSN： 0172-6390

  2384. Splenic vein occlusion secondary to tuberculous lymphadenitis at the splenic hilum: Report of a case Peer-reviewed

    Heigo Takeuchi, Masanori Suzuki, Michiaki Unno, Tetsuya Kakita, Seiki Matsuno, Hiroshi Nakura

    Surgery Today　30　(4)　383-385　2000

    Publisher: Springer Japan

    DOI： 10.1007/s005950050606 　

    ISSN： 0941-1291

  2385. Correlation between plasma and hepatic phosphatidylcholine hydroperoxide, energy charge, and total glutathione content in ischemia reperfusion injury of rat liver Peer-reviewed

    M. Suzuki, K. Fukuhara, M. Unno, T. Htwe, H. Takeuchi, T. Kakita, S. Matsuno

    Hepato-Gastroenterology　47　(34)　1082-1089　2000

    ISSN： 0172-6390

  2386. A study of liver metastasis from colorectal cancer in which hepatic resection was performed after hepatic arterial infusion chemotherapy Peer-reviewed

    H. Yoshida, M. Suzuki, M. Unno, S. Matsuno, T. Ogasawara, H. Yamazaki

    Japanese Journal of Gastroenterology　97　(10)　1252-1260　2000

    ISSN： 0446-6586

  2387. A case of hepatocellula carcinoma with erythropoietic hemochromatosis due to myelodysplastic syndrome Peer-reviewed

    K. Nakagawa, M. Suzuki, M. Unno, K. Endo, Y. Katayose, S. Matuno

    Acta Hepatologica Japonica　41　(12)　823-828　2000

    Publisher: Japan Society of Hepatology

    DOI： 10.2957/kanzo.41.823 　

    ISSN： 0451-4203

  2388. 胃平滑筋肉腫の異時性肝転移再々発症例に対してPMCT及びopen MCTにて腫瘍制御を試みた1例 Peer-reviewed

    竹村真一, 鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 内山哲之, 山本久仁治, 松野正紀

    Journal of Microwave Surgery　17　171-176　1999/11

  2389. 孤立性肝転移を伴うZollinger-Ellison症候群に対してOpen MCTを施行した1例 Peer-reviewed

    山本久仁治, 鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 柴田近, 福島浩平, 舟山祐士, 内藤広郎, 佐々木巌, 松野正紀

    Journal of Microwave Surgery　17　177-185　1999/11

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.17.177 　

    ISSN： 0917-7728

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    Recently, the symptoms related to gastric hypersecretion in patients with Zollinger-Ellison syndrome (ZES) can be well controlled with histamine receptor antagonists or proton pump inhibitors. The radical treatment for patients with ZES is complete resection of the primary and metastatic tumor. However, metastatic liver tumors from the primary region, especially those occupying the hepatic hilum, are difficult to resect completely due to neighboring important vessels such as the portal vein or hepatic artery. We report a 52-year-old man showing ZES. He had a solitary metastatic tumor near the hepatic hilum, although the primary gastrinoma could not be detected in the pancreas or duodenum even by selective arterial secretin injection test (SASI test) or various diagnostic images. Transcatheteric arterial embolization therapy for the metastatic liver tumor had not controlled the tumor growth effectively, but open microwave coagulation therapy (MCT) for the metastatic liver tumor could decrease the serum level of gastrin and the tumor size remarkably. This case indicates that the MCT is able to improve the prognosis of the patients with unresectable liver metastases of neuroendocrine tumors.

  2390. 孤立性肝転移を伴う Zollinger-Ellison 症候群に対してOpen MCT を施行した１例 Peer-reviewed

    山本久仁治, 鈴木正徳, 海野倫明, 片寄 友, 柴田, 福島浩平, 内藤広郎, 松野正紀

    J. Microwave Surg　17　(.)　177-185　1999/10

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.17.177 　

    ISSN： 0917-7728

    More details Close

    Recently, the symptoms related to gastric hypersecretion in patients with Zollinger-Ellison syndrome (ZES) can be well controlled with histamine receptor antagonists or proton pump inhibitors. The radical treatment for patients with ZES is complete resection of the primary and metastatic tumor. However, metastatic liver tumors from the primary region, especially those occupying the hepatic hilum, are difficult to resect completely due to neighboring important vessels such as the portal vein or hepatic artery. We report a 52-year-old man showing ZES. He had a solitary metastatic tumor near the hepatic hilum, although the primary gastrinoma could not be detected in the pancreas or duodenum even by selective arterial secretin injection test (SASI test) or various diagnostic images. Transcatheteric arterial embolization therapy for the metastatic liver tumor had not controlled the tumor growth effectively, but open microwave coagulation therapy (MCT) for the metastatic liver tumor could decrease the serum level of gastrin and the tumor size remarkably. This case indicates that the MCT is able to improve the prognosis of the patients with unresectable liver metastases of neuroendocrine tumors.

  2391. 肝腫瘍に対する３次元超音波診断装置を用いた肝切除支援の実際 Peer-reviewed

    鈴木正徳, 海野倫明, 遠藤公人, 片寄, 岩指 元, 及, 柿田徹也, 松野

    映像情報MEDICAL　31　(18)　1054-1059　1999/09

  2392. 幽門輪温存膵頭十二指腸切除術後遠隔期に発症した急性汎発性腹膜炎の１例 Peer-reviewed

    及川昌也, 鈴木正徳, 海野倫明, 竹村真一, 松野

    日臨外会誌　60　(9)　2584-2588　1999/09

    DOI： 10.3919/jjsa.60.2484 　

  2393. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Peer-reviewed

    Abe Takaaki, Masayuki Kakyo, Taro Tokui, Rie Nakagomi, Toshiyuki Nishio, Daisuke Nakai, Hideki Nomura, Michiaki Unno, Masanori Suzuki, Takeshi Naitoh, Seiki Matsuno, Hiromu Yawo

    Journal of Biological Chemistry　274　(24)　17159-17163　1999/06/11

    DOI： 10.1074/jbc.274.24.17159 　

    ISSN： 0021-9258

  2394. 三次元超音波診断装置を用いた肝門部胆管癌の局所浸潤診断能の評価 Peer-reviewed

    鈴木正徳, 海野倫明, 及川昌也, 遠藤公人, 片寄友, 松野正紀

    胆道　13　(2)　81-88　1999/05

    DOI： 10.11210/tando1987.13.2_81 　

  2395. Induction of epithelial Na+channel in rat ileum after proctocolectomy

    Kaori Koyama, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Kouhei Fukushima, Michiaki Unno, Seiki Matsuno, Hisayoshi Hayashi, Yuichi Suzuki

    American Journal of Physiology-Gastrointestinal and Liver Physiology　276　(4)　G975-G984　1999/04/01

    Publisher: American Physiological Society

    DOI： 10.1152/ajpgi.1999.276.4.g975 　

    ISSN： 0193-1857

    eISSN： 1522-1547

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    In patients with colectomy, epithelial transport function in the remnant small intestine can be regulated in response to the increased fecal electrolyte and fluid loss. Using a rat colectomy model, we investigated the Na+ and K+ transport mechanisms underlying the intestinal response. Proctocolectomy with ileoanal anastomosis was performed on rats. The small intestinal mucosa was mounted in Ussing chambers; then short-circuit currents and22Na+fluxes were measured. mRNA expression of the epithelial Na+ channel (ENaC) was determined by Northern blotting. Amiloride-sensitive, electrogenic Na+ absorption appeared in the ileum after proctocolectomy. This functional change was accompanied by the chronological induction of mRNAs for α-, β-, and γ-subunits of the ENaC in the ileum. Tetraethylammonium-sensitive short-circuit current was also activated. We conclude that electrogenic Na+ absorption and probably K+ secretion are induced in the ileum after proctocolectomy. This induction of electrogenic Na+ absorption is probably mediated by the increase in the mRNA levels for all three types of subunits of the ENaC and may contribute to the recovery from the increased fecal Na+ loss.

  2396. The degree of hepatic regeneration after partial hepatectomy in rats with peritonitis and the role of lipid peroxidation Peer-reviewed

    Kenji Fukuhara, Masanori Suzuki, Michiaki Unno, Mohammad Masihur Rahman, Kojin Endo, Seiki Matsuno

    Free Radical Biology and Medicine　26　(7-8)　881-886　1999/04

    DOI： 10.1016/S0891-5849(98)00280-9 　

    ISSN： 0891-5849

  2397. 胃平滑筋肉腫の異時性肝転移再々発症例に対してPMCTおよびopen MCTにて腫瘍制御を試みた１例 Peer-reviewed

    竹村真一, 鈴木正徳, 海野倫明, 片寄 友, 内, 山本久仁治

    J Microwave Surg　17　(.)　171-176　1999/04

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.17.171 　

    ISSN： 0917-7728

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    Gastrointestinal leiomyosarcoma usually results in repeated liver metastases or peritoneal disseminations during a long clinical course. Considering the therapeutic strategies for these liver metastases other than operative hepatic resection, percutaneous ethanol injection therapy (PEIT) or transcatheteric arterial embolization (TAE) may be not very effective due to the tumor's solidity and hypovascularity. Recently, microwave coagulonecrotic therapy (MCT) is becoming familiar as one of the strategies for liver tumors. We performed percutaneous MCT (PMCT) and open MCT consecutively for one case of an unresectable second recurrent metastatic liver tumor of gastric leiomyosarcoma and were able to control the growth of the tumor.<br>In our present strategy for liver metastases of leiomyosarcoma, small metastases under 2 cm in diameter are treated by PMCT or open MCT, but for large metastatic tumors, hepatectomy should be chosen in cases in which operative curability can be expected. In terms of quality of life, it is possible to employ open MCT aggressively for huge metastatic liver tumors that can not be resected for anatomical reasons.

  2398. Computed tomography during arterial portography(CTAP)からみた胆嚢静脈環流領域の同定 Peer-reviewed

    山本久仁治, 鈴木正徳, 海野倫明, 片寄 友, 小, 孫 正友, 松野

    胆と膵　20　(8)　597-693　1999/04

  2399. 制御困難な肝切離面出血に対してgelatin-resorcin formaldehyde(GRF)glueが有効であった1例 Peer-reviewed

    内山哲之, 鈴木正徳, 福原賢治, 海野倫明, 遠藤公人, 及川昌也, 竹村真一, 松野正紀

    外科　61　(2)　209-212　1999/02

  2400. Kupffer Cell-Mediated Inhibition of Liver Regeneration after Combined Hepatectomy and Pancreatectomy Peer-reviewed

    Toshiki Rikiyama, Masanori Suzuki, Michiaki Unno, Kenji Fukuhara, Tetsuyuki Uchiyama, Seiki Matsuno

    Journal of Gastrointestinal Surgery　3　(6)　654-661　1999

    Publisher: Elsevier Inc.

    DOI： 10.1016/S1091-255X(99)80089-4 　

    ISSN： 1091-255X

  2401. Induction of epithelial Na + channel in rat ileum after proctocolectomy Peer-reviewed

    Kaori Koyama, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Kouhei Fukushima, Michiaki Unno, Seiki Matsuno, Hisayoshi Hayashi, Yuichi Suzuki

    American Journal of Physiology　276　(4)　G975-G984　1999

    ISSN： 0002-9513

  2402. Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1 Peer-reviewed

    M. Kakyo, M. Unno, T. Tokui, R. Nakagomi, T. Nishio, H. Iwasashi, D. Nakai, M. Seki, M. Suzuki, T. Naitoh, S. Matsuno, H. Yawo, T. Abe

    Gastroenterology　117　(4)　770-775　1999

    Publisher: W.B. Saunders

    DOI： 10.1016/S0016-5085(99)70333-1 　

    ISSN： 0016-5085

  2403. Hepatic phosphatidylcholine hydroperoxide content in noncirrhotic, cirrhotic, and antioxidant-treated rats with endotoxemia Peer-reviewed

    Mohammad Masihur Rahman, Masanori Suzuki, Michiaki Unno, Kojin Endo, Heigo Takeuchi, Tetsuya Kakita, Seiki Matsuno

    Surgery Today　29　(10)　1047-1052　1999

    DOI： 10.1007/s005950050643 　

    ISSN： 0941-1291

  2404. Changes in the tissue and plasma lipid peroxides, and significance of mesurment of lipid peroxides following hepatic inchemia and reperfusion Peer-reviewed

    T. Yamaki, M. Suzuki, K. Hukuhara, M. Unno, K. Endo, H. Takeuchi, T. Kakita, S. Matuno

    Japanese Journal of Gastroenterological Surgery　32　(8)　2077-2084　1999

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.32.2077 　

    ISSN： 0386-9768

  2405. 肝虚血再灌流障害発生における細胞内superoxide産生系の関与 CuZn-SOD過剰発現トランスジェニックマウスを用いた検討 Peer-reviewed

    竹内丙午, 鈴木正徳, 福原賢治, 海野倫明, 八巻孝之, 松野正紀

    肝臓　40　(1)　13-19　1999/01

    Publisher: The Japan Society of Hepatology

    DOI： 10.2957/kanzo.40.13 　

    ISSN： 0451-4203

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    Reactive oxygen species have been involved in pathogenesis of ischemia/reperfusion injury of the liver. It is hypothesized that the phagocytic cells mainly generate the free radicals in reperfusion injury. The aim of this study was to determine whether superoxide radicals are generated in cytoplasm following warm ischemia/reperfusion of murine liver. Transgenic mice overexpressing CuZn superoxide dismutase and normal mice underwent partial-liver ischemia and reperfusion for this purpose. Partial ischemia was performed by clamping hepatic vessels of left and median lobes for 15 minutes. We measured alanine aminotransferase (ALT), hyaluronic acid and phosphatidylcholine hydroperoxide (PCOOH) which was a primary peroxidative product of main component of cell membrane. Forty-five minutes after reperfusion, plasma ALT and PCOOH concentration in the liver were significantly decreased in transgenic mice compared to normal mice. These results suggest that superoxide radicals produced in cytoplasm play a definitive role in the tissue injury after reperfusion of the liver.

  2406. Surgical treatment of hepatocellular carcinoma: A rational strategy based on therapeutic outcome Peer-reviewed

    M. Suzuki, K. Fukuhara, M. Unno, H. Takeuchi, N. Sakurai, H. Kodama, M. Oikawa, S. Matsuno

    Japanese Journal of Gastroenterological Surgery　32　(4)　1048-1053　1999

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.32.1048 　

    ISSN： 0386-9768

  2407. 肝切除術時に発症したビタミンB1欠乏性代謝性アシドーシスの1例 Peer-reviewed

    及川昌也, 鈴木正徳, 海野倫明, 遠藤公人, 内山哲之, 木村良直, 中嶋康之, 松野正紀

    外科と代謝・栄養　32　(6)　351-356　1998/12

  2408. 慢性腎不全を合併した胆管細胞癌に対してマイクロ波凝固壊死療法を施行した1例 Peer-reviewed

    竹村真一, 鈴木正徳, 海野倫明, 遠藤公人, 内山哲之, 松野正紀

    Journal of Microwave Surgery　16　117-123　1998/11

    Publisher: Study Group of Microwave Surgery

    DOI： 10.3380/jmicrowavesurg.16.117 　

    ISSN： 0917-7728

    More details Close

    Recently, microwave coagulo-necrotic therapy (MCN) is becoming popular as one of the therapy for hepatocellular carcinoma (HCC). But it is not clear whether MCN is an effective treatment for adenocarcinoma as metastatic liver tumor or cholangiocellular carcinoma (CCC). We performed open MCN for a case of CCC with chronic renal failure.<br>This case was 76 years old male patient. Abdominal CT scan showed a low density mass about 3.5 cm in diameter in the caudate lobe of the liver and compressed inferior vena cava. Considering his poor health status, advanced age and history of chronic renal failure, curative operation with caudate hepatic lobectomy and the resection of inferior vena cava was impossible. So we selected the open MCN bacause of low operative stress and shorter time. Using 30 mm and 10 mm needle, we performed MCN for the tumor all over.<br>Postoperative course was uneventful and without complications. Through this case, we study and report the effect of MCN for CCC.

  2409. 横断画像上 Segment IX を含む肝尾状葉が明瞭に識別できた肝門部癌の１例 Peer-reviewed

    柿田徹也, 鈴木正徳, 海野倫明, 佐藤明弘, 松野正紀

    胆と膵　19　(8)　711-715　1998/08

  2410. 横断画像上Segment IXを含む肝尾状葉が明瞭に識別できた肝門部癌の1例 Peer-reviewed

    柿田徹也, 鈴木正徳, 海野倫明, 遠藤公人, 佐藤明弘, 石橋忠司, 松野正紀

    胆と膵　19　(8)　711-715　1998/08

  2411. 硬変肝切除後の肝再生とエネルギー代謝に与える外因性脂肪投与の意義 Peer-reviewed

    坂本宣英, 鈴木正徳, 福原賢治, 海野倫明, 竹内丙午, 内山哲之, 岩指元, 松野正紀

    外科と代謝・栄養　32　(4)　241-250　1998/07

  2412. 肝門部悪性胆道狭窄に対するY型stentingの手技に関する工夫 Peer-reviewed

    及川昌也, 鈴木正徳, 海野倫明

    胆と膵　19　(6)　501-506　1998/06

  2413. 胆石併存胆嚢癌症例からみた胆石と発がんの関連について Peer-reviewed

    海野倫明, 鈴木正徳, 松野正紀

    臨床と研究　75　(5)　1001-1005　1998/05

  2414. 肝膵同時切除術後の肝再生抑制とparacrine機構からみたInterleukin-10の意義 Peer-reviewed

    内山哲之, 鈴木正徳, 海野倫明

    肝臓　39　(5)　360-362　1998/05

    Publisher: The Japan Society of Hepatology

    DOI： 10.2957/kanzo.39.360 　

    ISSN： 0451-4203

  2415. 【肝癌に対する現時点でのSMANCSの評価】 SMANCS動注単独投与 切除不能肝細胞癌に対するSMANCS/Lipiodol動注療法の功罪 Peer-reviewed

    鈴木正徳, 福原賢治, 海野倫明

    癌と化学療法　25　(Suppl.I)　39-45　1998/02

  2416. Simplified hepatic resection utilizing absorbable polyglycolic acid-based tape and other ligature apparatus Peer-reviewed

    Masanori Suzuki, Kenji Fukuhara, Michiaki Unno, Toshiki Rikiyama, Heigo Takeuchi, Tetsuyuki Uchiyama, Seiki Matsuno

    Journal of Hepato-Biliary-Pancreatic Surgery　5　(3)　292-296　1998

    Publisher: Springer Japan

    DOI： 10.1007/s005340050048 　

    ISSN： 0944-1166

  2417. 【糖尿病】特論 その他の重要事項 Reg遺伝子とその産物Reg蛋白質の構造と機能 新しい糖尿病治療への展望を求めて

    海野 倫明, 那谷 耕司, 成島 陽一

    日本臨床　55　(増刊 糖尿病(2))　817-821　1997/11

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  2418. [Structure and biological function of Reg genes and Reg proteins]

    Unno M, Nata K, Narushima Y, Takasawa S, Okamoto H, Matsuno S

    Nippon Rinsho　55 Suppl　817-821　1997/11

  2419. A case of poorly differentiated hepatocellular carcinoma with extremely rapid growth: An immunohistochemical study with monoclonal antibody MIB-1 Peer-reviewed

    Tetsuyuki Uchiyama, Masanori Suzuki, Kenji Fukuhara, Michiaki Unno, Seiki Matsuno, Takao Iwasaki, Takehiro Akahane, Mareyuki Endoh

    Japanese Journal of Gastroenterology　94　(9)　622-626　1997/09

    ISSN： 0446-6586

  2420. ジノスタチン スチマラマー反復肝動注後のショックに抗ヒスタミン薬が著効した肝細胞癌の1例 Peer-reviewed

    福原賢治, 鈴木正徳, 海野倫明

    癌と化学療法　24　(8)　1023-1026　1997/06

  2421. 細胞膜脂質過酸化物phosphatidylcholine hydroperoxide血中濃度による肝虚血再灌流障害の評価 Peer-reviewed

    福原賢治, 鈴木正徳, 海野倫明

    日本外科学会雑誌　98　(4)　470-470　1997/04

    ISSN： 0301-4894

  2422. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIIIα, RegIIIβ, RegIIIγ Peer-reviewed

    Yoichi Narushima, Michiaki Unno, Kan-Ichi Nakagawara, Mitsuko Mori, Hikari Miyashita, Yoshihisa Suzuki, Naoya Noguchi, Shin Takasawa, Tomoko Kumagai, Hideto Yonekura, Hiroshi Okamoto

    Gene　185　(2)　159-168　1997/02/07

    DOI： 10.1016/S0378-1119(96)00589-6 　

    ISSN： 0378-1119

  2423. Clinicopathologic Evaluation of 49 Patients of Cystic Diseases of the Liver Peer-reviewed

    Heigo Takeuchi, Masanori Suzuki, Fukuhara Kenji, Michiaki Unno, Koujin Endou, Youichi Narushima, Toshiki Rikiyama, Nobuhide Sakamoto, Masao Shinoda, Seiki Matsuno

    Japanese Journal of Gastroenterological Surgery　30　(3)　719-723　1997

    Publisher: Japanese Society of Gastroenterological Surgery

    DOI： 10.5833/jjgs.30.719 　

    ISSN： 0386-9768

  2424. Gallbladder metastasis from renal cell carcinoma - A report of a case Peer-reviewed

    Tetsuyuki Uchiyama, Masanori Suzuki, Kenji Fukuhara, Michiaki Unno, Hideo Ise, Seiki Matsuno

    Japanese Journal of Gastroenterology　94　(1)　68-72　1997/01

    ISSN： 0446-6586

  2425. An anaphylactic shock case after hepatic arterial infusion of Zinostatin Stimalamer suspension improved by anti-histaminics Peer-reviewed

    K. Fukuhara, M. Suzuki, M. Unno, T. Rikiyama, N. Sakamoto, H. Takeuchi, T. Uchiyama, T. Yamaki, H. Iwasashi, H. Kodama, S. Matsuno

    Japanese Journal of Cancer and Chemotherapy　24　(8)　1023-1026　1997

    ISSN： 0385-0684

  2426. 肝癌症例フイルム呈示によるアンケート集計報告からみた東北地方における肝細胞癌治療の現況 Peer-reviewed

    鈴木正徳, 福原賢治, 海野倫明

    新薬と臨床　45　(9)　1845-1855　1996/09

  2427. 腸管に発現する有機アニオントランスポーターの単離と機能解析 Peer-reviewed

    海野倫明, 小野川徹, 藤原 耕, 安達尚宣, 近藤典子, 鹿郷昌之, 鈴木正徳, 松野正紀, 阿部高明, 徳井太郎

    消化と吸収　23　(1)　32-36　1996/04

  2428. 下血を主訴として発見された Meckel 憩室腫瘍の１例 Peer-reviewed

    坂田直昭, 鈴木正徳, 海野倫明, 遠藤公人, 松野正紀, 大谷明夫

    日臨外会誌　62　(2)　415-420　1996/04

    DOI： 10.3919/jjsa.62.415 　

  2429. 3. 肝膵同時切除術後の肝非実質細胞を介した肝再生抑制機構 〜ラット肝・膵同時切除モデルを用いた実験的検討〜 Peer-reviewed

    鈴木正徳, 力山敏樹, 海野倫明, 内山哲之, 及川昌也, 松野正紀

    日外会誌　102　(2)　203-209　1996/04

  2430. 肝特異的トランスポーター蛋白を用いた人工脂質二重膜による無細胞人工肝臓の開発 Peer-reviewed

    海野倫明

    東北医誌　112　180-182　1996/04

  2431. 肝門部胆管癌に対する腫瘍形態に応じた治療法選択の可能性について Peer-reviewed

    鈴木正徳, 海野倫明, 遠藤公人, 片寄 友, 竹内丙午, 竹村真一, 及川昌也, 松野

    胆道　15　(1)　25-34　1996/04

    DOI： 10.11210/tando1987.15.1_25 　

  2432. 胆道メタリックステンティングの問題点と対策 放射線化学療法併用と胆道ステンティング Peer-reviewed

    鈴木正徳, 海野倫明, 片寄 友, 竹内丙午, 及川昌也, 小野川徹, 林 洋毅, 佐藤武揚, 松野正紀

    胆と膵　22　(3)　255-259　1996/04

  2433. 高線量率192Ir線源専用新規アプリケーターを用いた切除不能肝外胆管癌に対する低侵襲性chemoradiation 併用胆道 stenting Peer-reviewed

    鈴木正徳, 佐藤武揚, 海野倫明, 片寄 友, 竹内丙午, 及川昌也, 小野川徹, 林, 弘毅, 松野正紀, 松下晴雄

    胆と膵　22　(8)　683-689　1996/04

  2434. 組織接着閉鎖剤の種類と特徴 Peer-reviewed

    鈴木正徳, 海野倫明, 片寄 友, 竹内丙午, 小野川徹, 大塚英郎, 及川昌也, 松野正

    Surgery Frontier　8　(4)　100-104　1996/04

  2435. 胆汁酸トランスポーター機構の変化 ─LST/OATPファミリーの機能と転写調節─ Peer-reviewed

    海野倫明, 近藤典子, 阿部高明, 小野川徹, 藤原, 耕, 安達尚宣, 鈴木正徳, 松野

    肝胆膵　43　(6)　1021-1027　1996/04

  2436. インターフェロン著効後、約６年の経過で発症した肝細胞癌の１例 Peer-reviewed

    坂田直昭, 鈴木正徳, 海野倫明, 及川昌也, 松野正紀, 遠藤希之

    日臨外会誌　63　(3)　761-766　1996/04

    DOI： 10.3919/jjsa.62.761 　

  2437. 有機アニオントランスポーターoatp/LSTとその機能 Peer-reviewed

    阿部高明, 海野倫明, 小野川徹, 徳井太郎

    蛋白質・核酸・酵素　46　(5)　612-620　1996/04

  2438. 肝部下大静脈に隣接した転移性肝腫瘍に対して、流入流出路結構遮断下、, 中肝静脈経由でopen MCTを施行して有効であった一症例 Peer-reviewed

    水間正道, 鈴木正徳, 海野倫明, 片寄 友, 遠藤公人, 及川昌也, 山本久仁治, 松野正紀, 鈴木幸正

    J Microwave Surg　19　89-92　1996/04

  2439. 新しい有機アニオントランスポーターLST-2は消化器癌に異所性に発現しMTX感受性を担う Peer-reviewed

    小野川徹, 海野倫明, 近藤典子, 安達尚宣, 藤原, 耕, 鈴木正徳, 大谷明夫, 佐藤永一, 名倉 宏, 阿部高明, 松野

    東北医誌　113　(1)　91-93　1996/04

  2440. 臓器機能再生と再建のための手術：門脈修復 Peer-reviewed

    片寄 友, 鈴木正徳, 海野倫明, 竹内丙午, 松野正

    手術　55　(8)　1215-1221　1996/04

  2441. A Case Report of Multiple Endocrine Neoplasia Type 1 with Duodenal Microgastrinoma and Pancreatic Insulinoma Peer-reviewed

    Takashi Doi, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Yasuhiko Kamiyama, Michinaga Takahashi, Kouhei Fukushima, Chikashi Shibata, Vhideo Segami, Noriya Otani, Akihiro Iwatsuki, Seiki Matsuno, Michiaki Unno, Seiichi Ohira

    Japanese Journal of Gastroenterological Surgery　28　(4)　850-854　1995

    DOI： 10.5833/jjgs.28.850 　

    ISSN： 1348-9372 0386-9768

  2442. Characterization of the 5′-regulatory region of rat Reg I gene Peer-reviewed

    Hikari Miyashita, Hideto Yonekura, Michiaki Unno, Yoshihisa Suzuki, Takuo Watanabe, Shigeki Moriizumi, Shin Takasawa, Hiroshi Okamoto

    BBA - Gene Structure and Expression　1219　(1)　241-243　1994/09/13

    DOI： 10.1016/0167-4781(94)90281-X 　

    ISSN： 0167-4781

  2443. Structure and expression of a novel rat RegIII gene Peer-reviewed

    Suzuki Yoshihisa, Yonekura Hideto, Watanabe Takuo, Unno Michiaki, Moriizumi Shigeki, Miyashita Hikari, Okamoto Hiroshi

    Gene　144　(2)　315-316　1994/07/08

    DOI： 10.1016/0378-1119(94)90399-9 　

    ISSN： 0378-1119

  2444. Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein Peer-reviewed

    Takuo Watanabe, Yutaka Yonemura, Hideto Yonekura, Yoshihisa Suzuki, Hikari Miyashita, Kazuo Sugiyama, Shigeki Moriizumi, Michiaki Unno, Osamu Tanaka, Hisatake Kondo, Adrian J. Bone, Shin Takasawa, Hiroshi Okamoto

    Proceedings of the National Academy of Sciences of the United States of America　91　(9)　3589-3592　1994/04/26

    Publisher: National Academy of Sciences

    DOI： 10.1073/pnas.91.9.3589 　

    ISSN： 0027-8424

  2445. Isolation, structural determination and expression of a novel reg gene, human reg Iβ Peer-reviewed

    Shigeki Moriizumi, Takuo Watanabe, Michiaki Unno, Kan-ichi Nakagawara, Yoshihisa Suzuki, Hikari Miyashita, Hideto Yonekura, Hiroshi Okamoto

    BBA - Gene Structure and Expression　1217　(2)　199-202　1994/03/01

    DOI： 10.1016/0167-4781(94)90035-3 　

    ISSN： 0167-4781

  2446. Obstructive jaundice associated with extrahepatic portal vein obstruction: Report of two cases Peer-reviewed

    Kiyoaki Ouchi, Tsuyoshi Tominaga, Michiaki Unno, Seiki Matsuno

    Surgery Today　23　(8)　737-741　1993/08

    Publisher: Springer-Verlag

    DOI： 10.1007/BF00311715 　

    ISSN： 0941-1291 1436-2813

  2447. Significance of subserosal lesions and results of extended cholecystectomy in the treatment of primary carcinoma of the gallbladder

    K. Ouchi, M. Suzuki, M. Unno, K. Endo, S. Matsuno

    Digestive Surgery　10　(5)　225-229　1993

    Publisher: S. Karger AG

    DOI： 10.1159/000172181 　

    ISSN： 0253-4886

  2448. The primary structure of rat rig/ribosomal protein S15 gene Peer-reviewed

    Shin Takasawa, Akira Tohgo, Michiaki Unno, Kiyoto Shiga, Hideto Yonekura, Hiroshi Okamoto

    BBA - Gene Structure and Expression　1132　(2)　228-230　1992/09/24

    DOI： 10.1016/0167-4781(92)90020-Z 　

    ISSN： 0167-4781

  2449. Structural determination of Saccharomyces cerevisiae rig gene and identification of its product as ribosomal protein S21 Peer-reviewed

    Shin Takasawa, Akira Tohgo, Michiaki Unno, Hideto Yonekura, Hiroshi Okamoto

    FEBS Letters　307　(3)　318-323　1992/08/03

    DOI： 10.1016/0014-5793(92)80704-K 　

    ISSN： 0014-5793

  2450. ISLET BETA-CELL REGENERATION AND REG GENES Peer-reviewed

    M UNNO, T ITOH, T WATANABE, H MIYASHITA, S MORIIZUMI, H TERAOKA, H YONEKURA, H OKAMOTO

    PANCREATIC ISLET CELL REGENERATION AND GROWTH　321　61-69　1992

  2451. A Completely Resected Case of Intraduodenal Malignant Gastrinoma by Utilizing Selective Arterial Secretin Injection Test and Intra-operative Secretin Test Peer-reviewed

    Chikashi Shibata, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Yasuhiko Kamiyama, Michinaga Takahashi, Kohei Fukushima, Hideo Segami, Takashi Doi, Akihiro Iwatsuki, Noriya Ohtani, Tooru Furukawa, Seiki Matsumo, Taisuke Nomura, Michiaki Unno, Hiroshi Okamoto

    The Japanese Journal Of Gastroenterological Surgery　24　(9)　2414-2418　1991/02/01

    DOI： 10.5833/jjgs.24.2414 　

    ISSN： 1348-9372 0386-9768

  2452. [Structure and expression of rig]

    Shiga K, Unno M, Takasawa S, Sugawara A, Inoue C, Kitagawa M, Tohgo A, Yamamoto H, Okamoto H

    Nippon Rinsho　49 Suppl　760-768　1991/02

  2453. 腎細胞癌の胆嚢転移の1例 転移性胆嚢腫瘍の形態学的考察を併せて Peer-reviewed

    鍋島 立秀, 学, 大学院消化器病態学分野, 菅野 敦, 正宗 淳, 益田 邦洋, 三浦 晋, 滝川 哲也, 森川 孝則, 藤島 史喜, 海野 倫明, 古川 徹, 下瀬川 徹

  2454. 胆嚢原発肝様腺癌の1例 Peer-reviewed

    佐野 貴紀, 民健康保険丸森病院, 内科, 菅野 敦, 田中 裕, 松本 諒太郎, 鍋島 立秀, 滝川 哲也, 三浦 晋, 森川 孝則, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 淳

Show all ︎Show first 5

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  1. 膵島移植に理想的な新規免疫抑制プロトコールの開発

    鈴木翔輝, 猪村武弘, 前川正充, 稲垣明子, 眞屋梢, 後藤めぐみ, 遠藤有希子, 片野匠, 戸子台和哲, 戸子台和哲, 海野倫明, 亀井尚, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　51st　2024

  2. 不織布構造ゼラチン基材を用いた新規膵島移植法の構築

    遠藤有希子, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　51st　2024

  3. 皮下膵島移植における低酸素環境改善が移植膵島グラフトに与える影響

    三頭啓明, 猪村武弘, 稲垣明子, 鈴木翔輝, 遠藤有希子, 片野匠, 戸子台和哲, 渡邉君子, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    膵臓(Web)　39　(3)　2024

    ISSN： 1881-2805

  4. 高異型度PanIN/膵上皮内癌・小径膵癌の分子進化モデル

    伊藤泰斗, 大森優子, 大森優子, 高橋賢治, 國米崇, 國米崇, 正宗淳, 海野倫明, 水上裕輔, 水上裕輔, 古川徹

    日本消化器病学会雑誌(Web)　121　2024

    ISSN： 1349-7693

  5. 転移性膵癌に対する治療戦略 膵癌切除例における腹腔細胞診疑陽性の臨床的意義 膵癌取扱い規約検討委員会研究

    田中 晴祥, 平林 健一, 藤井 努, 大池 信之, 上野 誠, 水井 崇浩, 石田 晶玄, 江川 新一, 古川 徹, 永川 裕一, 糸井 隆夫, 北川 裕久, 眞杉 洋平, 谷 眞至, 福嶋 敬宜, 羽鳥 隆, 里井 壯平, 海野 倫明, 竹山 宜典, 膵癌取扱い規約検討委員会

    膵臓　38　(3)　A156-A156　2023/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  6. 癌治療における術前術後集学的治療の現状と成績 腹腔洗浄細胞診陽性膵癌に対する集学的治療 Conversion Surgeryの適応と治療成績

    平野 直大, 中山 瞬, 水間 正道, 青木 修一, 井上 亨悦, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　48　(3)　274-274　2023/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  7. 膵切除後膵液瘻予防のコツ 腹腔鏡下膵尾側切除における術後膵瘻予防の工夫

    林 秀一郎, 石田 晶玄, 青木 修一, 井上 亨悦, 伊関 雅裕, 中山 瞬, 堂地 大輔, 三浦 孝之, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　48　(3)　289-289　2023/05

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    ISSN： 0385-7883

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  8. 肝胆膵良性疾患における標準的術式とその理論的背景 先天性胆道拡張症成人例に対する至適アプローチ法の検討

    森川 孝則, 大塚 英郎, 宮崎 健人, 日下 彬子, 井上 亨悦, 青木 修一, 伊関 雅裕, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 田中 直樹, 西條 文人, 水間 正道, 中川 圭, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

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  9. 癌免疫療法時代における外科医の役割 Interferon alpha-STAT3 axis制御による新規膵癌免疫治療 KRAS mutation subtype機能解析から得られた知見

    井上 亨悦, 宮崎 健人, 日下 彬子, 青木 修一, 伊関 雅裕, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 亀井 尚, Duda Dan, 海野 倫明

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  10. 膵癌に対する低侵襲治療の適応とベストプラクティス 当施設での膵癌に対する腹腔鏡下膵尾側切除術の適応と工夫

    石田 晶玄, 森川 孝則, 青木 修一, 井上 亨悦, 伊関 雅裕, 中山 瞬, 堂地 大輔, 三浦 孝之, 水間 正道, 大塚 英郎, 中川 圭, 亀井 尚, 海野 倫明

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  11. 膵管内乳頭粘液性腫瘍における新たな知見と外科治療指針 Intraductal oncocytic papillary neoplasm(IOPN)に対する外科治療成績

    三浦 孝之, 宮崎 健人, 日下 彬子, 井上 亨悦, 青木 修一, 伊関 雅裕, 中山 瞬, 堂地 大輔, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 古川 徹, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　WS-7　2023/04

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  12. 腹腔洗浄細胞診陽性膵癌に対する化学療法後の腹腔ポート細胞診陰転化の意義

    中山 瞬, 水間 正道, 有明 恭平, 日下 彬, 青木 修一, 井上 亨悦, 伊関 雅裕, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-7　2023/04

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  13. がん遺伝子パネル検査を受けた胆道癌症例に関する前向き観察研究

    堂地 大輔, 大塚 英郎, 廣岡 芳樹, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-1　2023/04

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  14. 胆道癌に対する審査腹腔鏡・門脈塞栓術併施の取り組み

    伊関 雅裕, 中川 圭, 青木 修一, 宮崎 健人, 日下 彬子, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-8　2023/04

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  15. GFPT2はGemcitabine刺激によって発現が誘導されヘキソサミン経路を介した癌細胞の移動・浸潤能を亢進する

    宮崎 健人, 有明 恭平, 石田 晶玄, 中山 舜, 井上 亨悦, 堂地 大輔, 青木 修一, 伊関 雅裕, 三浦 孝之, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-5　2023/04

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  16. 膵癌細胞におけるAtaxia-telangiectasia Mutated(ATM)の発現とその機能解析

    大塚 英郎, 荀 静宇, 宮崎 健人, 日下 彬子, 井上 亨悦, 青木 修一, 伊関 雅裕, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　SF-6　2023/04

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  17. GATA6とCK5の発現表現型が術前化学療法後の膵癌の予後を層別化する

    國米 崇, 大森 優子, 石田 晶玄, 伊達 文子, 三浦 晋, 中山 瞬, 堂地 大輔, 三浦 孝之, 粂 潔, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 正宗 淳, 亀井 尚, 海野 倫明, 古川 徹

    日本外科学会定期学術集会抄録集　123回　SF-1[Y]　2023/04

    Publisher: (一社)日本外科学会

  18. 肝門部胆管癌の切除適応と治療戦略

    中川 圭, 伊関 雅裕, 青木 修一, 日下 彬子, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-7　2023/04

    Publisher: (一社)日本外科学会

  19. 肝門部領域胆管癌における高齢者フレイルの評価と周術期管理の検討

    青木 修一, 中川 圭, 伊関 雅裕, 宮崎 健人, 日下 彬子, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-1　2023/04

    Publisher: (一社)日本外科学会

  20. 高度進行結腸癌に対する治療戦略 肥満症例における高度進行大腸癌(pT4,pN2)の腹腔鏡手術成績(LOVERY study副次解析)

    小林 実, 大沼 忍, 肥田 侯矢, 佐藤 誠二, 植村 守, 赤木 智徳, 河野 洋平, 中嶋 健太郎, 賀川 義規, 中村 隆俊, 猪股 雅史, 山本 聖一郎, 坂井 義治, 内藤 剛, 渡邊 昌彦, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　WS-6　2023/04

    Publisher: (一社)日本外科学会

  21. 肝内胆管癌におけるHGF/METシグナルの亢進は免疫抑制的な微小環境を創出する

    海野 裕一郎, 青木 修一, 村上 圭吾, 安藤 未佳, 柏木 良介, 井上 亨悦, 伊関 雅裕, 三浦 孝之, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　123回　DP-7　2023/04

    Publisher: (一社)日本外科学会

  22. GATA6とCK5の発現表現型が術前化学療法後の膵癌の予後を層別化する

    國米 崇, 大森 優子, 石田 晶玄, 伊達 文子, 三浦 晋, 中山 瞬, 堂地 大輔, 三浦 孝之, 粂 潔, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 正宗 淳, 亀井 尚, 海野 倫明, 古川 徹

    日本外科学会定期学術集会抄録集　123回　SF-1[Y]　2023/04

    Publisher: (一社)日本外科学会

  23. エストロゲン受容体陰性乳癌における細胞質内エストロゲン受容体は予後良好因子の可能性がある

    江幡 明子, 鈴木 貴, 多田 寛, 原田 成美, 濱中 洋平, 宮下 穣, 深町 佳世子, 柳垣 美歌, 進藤 晴彦, 角掛 聡子, 本成 登貴和, 山崎 あすみ, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 石田 孝宣

    日本外科学会定期学術集会抄録集　123回　DP-2　2023/04

    Publisher: (一社)日本外科学会

  24. 乳癌におけるSGLT1の発現と予後不良因子としての検討

    角掛 聡子, 岩渕 英里奈, 三木 康宏, 小野寺 好明, 多田 寛, 原田 成美, 宮下 穣, 濱中 洋平, 江幡 明子, 柳垣 美歌, 進藤 晴彦, 本成 登貴和, 山崎 あすみ, 和田 基, 大沼 忍, 亀井 尚, 海野 倫明, 笹野 公伸, 鈴木 貴, 石田 孝宣

    日本外科学会定期学術集会抄録集　123回　DP-4　2023/04

    Publisher: (一社)日本外科学会

  25. CLTI(包括的高度慢性下肢虚血)の治療選択 Distal Bypass術後のSPP連続測定から考えるDirect Revascularizationの意義

    芹澤 玄, 中野 善之, 佐々木 茂, 佐藤 博子, 橋本 宗敬, 玉手 義久, 鈴木 峻也, 大原 勝人, 河村 圭一郎, 渡辺 徹雄, 梅津 道久, 小笠原 紀信, 清水 港太, 木村 俊作, 赤松 大二朗, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　123回　WS-7　2023/04

    Publisher: (一社)日本外科学会

  26. Molecular Phenotyping and the Combinatorial System by the Number of Accumulated Gene Alterations of Intraductal Papillary Mucinous Neoplasms Stratifies the Risk of Invasion and Outcome: New Insight for Management Strategy

    Yuko Omori, Yusuke Ono, Takashi Kokumai, Fumiko Date, Ryota Higuchi, Goro Honda, Yusuke Mizukami, Takanori Morikawa, Michiaki Unno, Toru Furukawa

    LABORATORY INVESTIGATION　103　(3)　S1520-S1520　2023/03

    ISSN： 0023-6837

    eISSN： 1530-0307

  27. 膵切除後残膵病変の発生パターンの検討

    伊関 雅裕, 水間 正道, 國米 崇, 柏木 良介, 日下 彬子, 青木 修一, 井上 亨悦, 中山 瞬, 堂地 大輔, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　214回　105-105　2023/02

    Publisher: 日本消化器病学会-東北支部

  28. 術後合併症に対するIVR・内視鏡的ドレナージ治療 消化器外科術後合併症に対するVIABAHNステントグラフトの治療成績

    三浦 孝之, 日下 彬子, 井上 亨悦, 青木 修一, 伊関 雅裕, 堂地 大輔, 中山 瞬, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 高瀬 圭, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　43　(2)　357-357　2023/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  29. 不織布構造ゼラチン基材と脂肪由来幹細胞の併用による皮下膵島移植成績の検討

    齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 遠藤有希子, 三頭啓明, 金井哲史, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023

  30. 不織布構造ゼラチン基材の前留置期間が皮下膵島移植のグラフト生着へ及ぼす影響に関する検討

    齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 遠藤有希子, 三頭啓明, 金井哲史, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023

  31. 低酸素環境改善を目的とした新規組織内酸素濃度測定法の開発と皮下膵島移植への応用

    三頭啓明, 猪村武弘, 稲垣明子, 鈴木翔輝, 遠藤有希子, 片野匠, 齋藤竜助, 戸子台和哲, 渡邉君子, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023

  32. BACH1 promotes metastasis of pancreatic cancer

    佐藤正規, 大塚英郎, 水間正道, 松本光代, 斎木由利子, 大沼忍, 中川圭, 亀井尚, 五十嵐和彦, 海野倫明

    日本がん転移学会学術集会・総会プログラム抄録集　32nd　2023

  33. 膵退形成癌に対する術前治療

    水間正道, 國米崇, 柏木良介, 日下彬子, 青木修一, 伊関雅裕, 井上亨悦, 堂地大輔, 中山瞬, 三浦孝之, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 大沼忍, 粂潔, 正宗淳, 亀井尚, 海野倫明

    日本消化器外科学会雑誌(Web)　56　(Supplement2)　2023

    ISSN： 1348-9372

  34. Orthotopic colon cancer model recapitulates the histological findings associated with LN metastasis

    唐澤秀明, 村上圭吾, 三浦康, 佐々木宏之, 小野智之, 小林実, 梶原大輝, 亀井尚, 大沼忍, 海野倫明

    日本がん転移学会学術集会・総会プログラム抄録集　32nd　2023

  35. 東北大学における膵島移植の保険診療実施体制の構築

    沖田ひとみ, 伊藤貴子, 佐藤則子, 佐藤則子, 藤尾淳, 戸子台和哲, 戸子台和哲, 戸子台和哲, 岡田克典, 岡田克典, 岡田克典, 海野倫明, 亀井尚, 亀井尚, 後藤昌史, 後藤昌史, 後藤昌史, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023

  36. Response Evaluation of the Neoadjuvant Therapy for Pancreatic Cancer

    堂地大輔, 國米崇, 佐藤英昭, 日下彬子, 青木修一, 伊関雅裕, 三浦孝之, 前田晋平, 石田晶玄, 大塚英郎, 水間正道, 中川圭, 海野倫明

    胆と膵　44　(8)　2023

    ISSN： 0388-9408

  37. Molecular phenotyping and risk stratification of intraductal papillary mucinous neoplasms.

    Yuko Omori, Yusuke Ono, Takashi Kokumai, Fumiko Date, Ryota Higuchi, Goro Honda, Yusuke Mizukami, Takanori Morikawa, Michiaki Unno, Toru Furukawa

    CANCER RESEARCH　82　(22)　170-170　2022/11

    ISSN： 0008-5472

    eISSN： 1538-7445

  38. 癌関連線維芽細胞はWntシグナル経路を介して大腸癌におけるリンパ行性転移に関与する

    唐澤 秀明, 村上 圭吾, 相澤 卓, 平嶋 倫亮, 三浦 康, 佐々木 宏之, 小野 智之, 小林 実, 梶原 大輝, 亀井 尚, 大沼 忍, 海野 倫明

    日本癌治療学会学術集会抄録集　60回　OF-5　2022/10

    Publisher: (一社)日本癌治療学会

  39. 【炎症性腸疾患治療における外科と内科の接点】Crohn病に対する腸管切除後のフォローアップと治療

    渡辺 和宏, 大沼 忍, 神山 篤史, 唐澤 秀明, 亀井 尚, 海野 倫明

    外科　84　(10)　1044-1048　2022/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  40. 外科系周術期栄養のアップデート 膵臓外科における周術期栄養評価の重要性

    森川 孝則, 石田 晶玄, 伊関 雅裕, 宮崎 健人, 日下 彬子, 井上 亨悦, 青木 修一, 中山 瞬, 堂地 大輔, 三浦 孝之, 大塚 英郎, 水間 正道, 中川 圭, 大沼 忍, 亀井 尚, 海野 倫明

    New Diet Therapy　38　(2)　100-100　2022/09

    Publisher: (一社)日本臨床栄養協会

    ISSN： 0910-7258

    eISSN： 2434-7159

  41. 【IBD術後の諸問題に対応する!】潰瘍性大腸炎術後の重篤な小腸炎

    神山 篤史, 福島 浩平, 渡辺 和宏, 大沼 忍, 海野 倫明

    IBD Research　16　(3)　143-148　2022/09

    Publisher: (株)先端医学社

    ISSN： 1881-6533

  42. 直腸切除後の排便排尿および性機能障害に対するスマート問診システムの確立と機能障害評価

    梶原 大輝, 大沼 忍, 市川 英孝, 小林 実, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 森川 孝則, 亀井 尚, 海野 倫明

    日本外科系連合学会誌　47　(4)　611-611　2022/08

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

    eISSN： 1882-9112

  43. 局所進行S状結腸癌に対する術前化学療法の短期成績

    唐澤 秀明, 市川 英孝, 小林 実, 梶原 大輝, 神山 篤史, 渡辺 和宏, 亀井 尚, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　77回　RS18-5　2022/07

    Publisher: (一社)日本消化器外科学会

  44. 当院における肝硬変及び維持透析症例の胸腔鏡下食道切除術の検討

    赤石 隆二郎, 谷山 裕亮, 佐藤 千晃, 岡本 宏史, 福富 俊明, 小澤 洋平, 小関 健, 大沼 忍, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　77回　P235-2　2022/07

    Publisher: (一社)日本消化器外科学会

  45. 当院における亜全胃温存膵頭十二指腸切除術後腹腔内出血の治療成績

    井上 亨悦, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 大沼 忍, 亀井 尚, 高瀬 圭, 海野 倫明

    日本消化器外科学会総会　77回　RS19-3　2022/07

    Publisher: (一社)日本消化器外科学会

  46. リンパ節転移陽性胃癌の術後腹膜再発リスク

    杉沢 徳彦, 田中 直樹, 山村 明寛, 井本 博文, 土屋 堯裕, 西條 文人, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　77回　P278-3　2022/07

    Publisher: (一社)日本消化器外科学会

  47. 早期胃癌ESD後の追加胃切除術における治療成績と安全性の検討

    佐々木 啓迪, 土屋 堯裕, 山村 明寛, 田中 直樹, 井本 博文, 八田 和久, 尾形 洋平, 宇野 要, 小池 智幸, 西條 文人, 森川 孝則, 大沼 忍, 正宗 淳, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　65-65　2022/07

    Publisher: 日本消化器病学会-東北支部

  48. 切除可能境界膵体部癌に対して術前治療により病理学的完全奏効が得られた1例

    平野 直大, 伊関 雅裕, 水間 正道, 野口 彩, 青木 修一, 井上 亨悦, 中山 瞬, 三浦 孝之, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 佐藤 真広, 粂 潔, 正宗 淳, 廣瀬 勝也, 古川 徹, 大沼 忍, 亀井 尚, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　213回　71-71　2022/07

    Publisher: 日本消化器病学会-東北支部

  49. 過去から学ぶ大規模災害における外科医と外科医局の役割

    宮城 重人, 石井 正, 赤松 大二朗, 原 康之, 谷山 裕亮, 田中 直樹, 大沼 忍, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　122回　SP-1　2022/04

    Publisher: (一社)日本外科学会

  50. 肥満症における腸管の意義 腸内環境から探る十二指腸空腸バイパス術の代謝改善効果

    土屋 尭裕, 田中 直樹, 井本 博文, 山村 明寛, 杉沢 徳彦, 市川 英孝, 佐々木 啓迪, 川名 友美, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　148-148　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  51. 減量・代謝改善手術の長期成績(5年以上)とフォローアップ 腹腔鏡下スリーブ状胃切除術の長期治療成績

    田中 直樹, 井本 博文, 土屋 尭裕, 山村 明寛, 杉沢 徳彦, 武田 みゆき, 田中 千尋, 布田 美貴子, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　249-249　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  52. 管理栄養士と医師が相互理解しながら、患者さんを多方面からサポートするには? 自力歩行不能で緊急入院となった超重症肥満症に対し術前栄養介入後スリーブ状胃切除術を施行した1例

    田中 千尋, 井本 博文, 武田 みゆき, 布田 美貴子, 土屋 尭裕, 杉沢 徳彦, 山村 明寛, 田中 直樹, 原田 卓, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　251-251　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  53. 管理栄養士と医師が相互理解しながら、患者さんを多方面からサポートするには? 比較的急な対応を要し多職種介入により良好な経過をたどった超重症肥満症例

    井本 博文, 田中 直樹, 土屋 尭裕, 山村 明寛, 杉沢 徳彦, 原田 卓, 布田 美貴子, 武田 みゆき, 田中 千尋, 森川 孝則, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　252-252　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  54. Revision surgery(減量不良・リバウンドならびに術後合併症)の実際と課題 スリーブ状胃切除術後通過障害に対する胃管固定術の有用性

    井本 博文, 田中 直樹, 山村 明寛, 杉沢 徳彦, 土屋 尭裕, 佐々木 啓迪, 川名 友美, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　264-264　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  55. ハイリスク患者に対する減量・代謝改善手術の意義と危険性 重度の心不全を合併した病的肥満患者に対する減量手術の有用性

    井本 博文, 田中 直樹, 山村 明寛, 杉沢 徳彦, 土屋 尭裕, 佐々木 啓迪, 川名 友美, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　271-271　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  56. BMI50以上の超重症肥満症例における肥満外科手術の現状

    土屋 尭裕, 田中 直樹, 井本 博文, 山村 明寛, 杉沢 徳彦, 佐々木 啓迪, 川名 友美, 大沼 忍, 森川 孝則, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　312-312　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  57. 病的肥満症を合併した腎細胞癌患者に対しスリーブ状胃切除術を先行して施行した一例

    佐々木 啓迪, 井本 博文, 田中 直樹, 山村 明寛, 土屋 尭裕, 杉沢 徳彦, 川名 友美, 大沼 忍, 亀井 尚, 海野 倫明

    肥満研究　27　(Suppl.)　366-366　2022/03

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  58. 患者由来IPMNオルガノイドとゲノム解析を用いた増殖形態の解明

    椎原正尋, 石川智彦, 大森優子, 元井冬彦, 森川孝則, 中川圭, 林洋毅, 水間正道, 大塚英郎, 岡村容伸, 木下賢吾, 海野倫明, 古川徹

    日本外科学会定期学術集会(Web)　122nd　2022

  59. 食道癌切除後乳び胸の危険因子に関する検討

    土谷祐馬, 谷山裕亮, 岡本宏史, 小関健, 小澤洋平, 福富俊明, 佐藤千晃, 亀井尚, 海野倫明

    日本食道学会学術集会抄録集(CD-ROM)　76th　2022

  60. 十二指腸乳頭部癌術後10年以上経過後に発症した膵管内転移の1例

    赤森洋太, 伊関雅裕, 國米崇, 國米崇, 井上亨悦, 中山瞬, 堂地大輔, 三浦孝之, 石田晶玄, 水間正道, 大塚英郎, 中川圭, 森川孝則, 亀井尚, 古川徹, 海野倫明

    日本臨床外科学会雑誌　83　(Supplement (Web))　2022

    ISSN： 1345-2843

  61. 皮下膵島移植における不織布構造ゼラチン基材の前留置期間に関する検討

    齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 遠藤有希子, 三頭啓明, 金井哲史, 宮城重人, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

    日本膵・膵島移植学会プログラム・抄録集　49th　2022

  62. 肝細胞と脂肪由来幹細胞の共移植による移植肝細胞生着促進効果

    山名浩樹, 稲垣明子, 猪村武弘, 中村保宏, 西牧宏泰, 片野匠, 大橋一夫, 宮城重人, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本移植学会総会プログラム抄録集　58th (Web)　2022

  63. 不織布構造ゼラチン基材と脂肪由来幹細胞の併用による皮下膵島移植の成績向上

    齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 遠藤有希子, 三頭啓明, 金井哲史, 宮城重人, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

    日本移植学会総会プログラム抄録集　58th (Web)　2022

  64. 皮下膵島移植における不織布構造ゼラチン基材の前留置期間が移植結果へ及ぼす影響

    齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 遠藤有希子, 三頭啓明, 金井哲史, 宮城重人, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

    日本移植学会総会プログラム抄録集　58th (Web)　2022

  65. 難治性食道狭窄を呈した微小ガストリノーマの1例

    草野啓介, 宇野要, 小池智幸, 三浦晋, 齊藤真弘, 金笑奕, 菅野武, 八田和久, 浅野直喜, 今谷晃, 正宗淳, 益田邦洋, 大塚英郎, 海野倫明, 藤島史喜, 中堀昌人

    日本消化器病学会東北支部例会誌　212th　2022

  66. 副腎皮質癌における腫瘍浸潤リンパ球とその臨床病理学的意義に関する検討

    石川裕貴, 山崎有人, 手塚雄太, 手塚雄太, 尾股慧, 尾股慧, 小野美澄, 小野美澄, 森本玲, 森本玲, 藤島史喜, 中村保宏, 佐藤文俊, 佐藤文俊, 伊藤明宏, 宮城重人, 宮城重人, 海野倫明, 海野倫明, 亀井尚, 亀井尚, 鈴木貴, 鈴木貴, 鈴木貴, 笹野公伸, 笹野公伸

    間脳・下垂体・副腎系研究会プログラム・抄録集(Web)　33rd　2022

  67. 基礎・臨床研究からみた消化管バイパス術導入の必要性

    内藤 剛, 田中 直樹, 井本 博文, 中馬 基博, 細田 桂, 海野 倫明, 佐藤 武郎, 山下 継史, 隈元 雄介, 比企 直樹

    日本内視鏡外科学会雑誌　26　(7)　SP1-2　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  68. 肥満外科手術の最新のエビデンス 消化管バイパス術の糖尿病改善効果の発現機序

    内藤 剛, 田中 直樹, 井本 博文, 中馬 基博, 細田 桂, 海野 倫明, 佐藤 武郎, 山下 継史, 隈元 雄介, 比企 直樹

    日本内視鏡外科学会雑誌　26　(7)　SY4-4　2021/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  69. 膵胆道癌オルガノイドの個別化医療モデルへの活用

    椎原正尋, 椎原正尋, 樋口亮太, 岡村容伸, 木下賢吾, 山本雅一, 元井冬彦, 海野倫明, 古川徹

    日本癌学会学術総会抄録集(Web)　80th　2021

  70. A successful case of pancreaticoduodenectomy after neoadjuvant therapy for pancreatic head cancer with acute pancreatitis due to iatrogenic injury of the pancreatic duct

    Kazuharu Chiba, Masamichi Mizuma, Fuyuhiko Motoi, Hirokif Hayashi, Shuichi Aoki, Tatsuo Hata, Tatsuyuki Takadate, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Takanori Morikawa, Takashi Kamei, Michiaki Unno

    Japanese Journal of Cancer and Chemotherapy　48　(1)　118-120　2021/01/01

    Publisher: Japanese Journal of Cancer and Chemotherapy Publishers Inc.

    ISSN： 0385-0684

  71. 術前に血管変異を伴わない右胸管を同定し温存しえた食道癌の1切除例

    土谷祐馬, 福富俊明, 高橋梢, 小澤洋平, 岡本宏史, 佐藤千晃, 谷山裕亮, 亀井尚, 海野倫明

    日本臨床外科学会雑誌　82　(Supplement (Web))　2021

    ISSN： 1345-2843

  72. 膵癌に対する予防域を含めた放射線治療における3DCRTとIMRTでの急性期有害事象の比較

    梅澤玲, 中川圭, 水間正道, 山本貴也, 石川陽二郎, 海野倫明, 神宮啓一

    日本癌治療学会学術集会(Web)　59th　2021

  73. STK11 Plays a Canonical Role in Malignant Progression of KRAS-mutant and GNAS-wild-type IPMNs

    大森優子, 小野裕介, 小野裕介, 森川孝則, 元井冬彦, 樋口亮太, 山本雅一, 唐崎秀則, 水上裕輔, 水上裕輔, 海野倫明, 古川徹

    日本病理学会会誌　110　(1)　2021

    ISSN： 0300-9181

  74. Molecular biomarkers for progression of IPMNs focused on epithelial subtypes

    大森優子, 小野裕介, 小野裕介, 森川孝則, 伊達文子, 樋口亮太, 山本雅一, 唐崎秀則, 水上裕輔, 水上裕輔, 海野倫明, 古川徹

    日本病理学会会誌　110　(1)　2021

    ISSN： 0300-9181

  75. 内分泌療法耐性乳癌における代謝の変化

    進藤晴彦, 原田成美, 多田寛, 宮下穣, 濱中洋平, 佐藤章子, 江幡明子, 本成登貴和, 金井綾子, 柳垣美歌, 角掛聡子, 鈴木貴, 海野倫明, 亀井尚, 石田孝宣

    日本外科学会定期学術集会(Web)　121st　2021

  76. BRACAnalysis保険適用後の現状と問題点

    江幡明子, 多田寛, 宮下穣, 原田成美, 佐藤章子, 濱中洋平, 深町佳世子, 佐藤未来, 金井綾子, 本成登貴和, 柳垣美歌, 進藤晴彦, 角掛聡子, 海野倫明, 亀井尚, 石田孝宣

    日本外科学会定期学術集会(Web)　121st　2021

  77. 乳癌治療におけるがん遺伝子パネル検査の最適な活用の考察

    多田寛, 宮下穣, 原田成美, 佐藤章子, 濱中洋平, 江幡明子, 海野倫明, 亀井尚, 石田孝宣

    日本外科学会定期学術集会(Web)　121st　2021

  78. 不織布構造ゼラチン基材の導入による経門脈移植を凌駕する革新的皮下膵島移植法の確立

    金井哲史, 稲垣明子, 中村保宏, 猪村武弘, FATHI Ibrahim, 三頭啓明, 斎藤竜助, 宮城重人, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　48th　2021

  79. Organoid培養とゲノム解析を用いた膵胆道癌の個別化医療システムの開発

    椎原正尋, 碇直樹, 樋口亮太, 山本雅一, 森川孝則, 中川圭, 林洋毅, 水間正道, 大塚英郎, 元井冬彦, 元井冬彦, 海野倫明, 岡村容伸, 木下賢吾, 古川徹

    日本外科学会定期学術集会(Web)　121st　2021

  80. 切除膵癌における腹腔洗浄細胞診の意義の検討 日本膵臓学会プロジェクト研究結果より

    藤井 努, 土田 浩喜, 水間 正道, 里井 壯平, 江口 英利, 五十嵐 久人, 北野 雅之, 黒木 保, 清水 泰博, 谷 眞至, 丹野 誠志, 辻 喜久, 廣岡 芳樹, 正宗 淳, 海野 倫明, 山上 裕機, 岡崎 和一

    膵臓　35　(3)　A101-A101　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  81. 膵全摘術の現状と展望 高齢者に対する膵全摘の問題と対策

    伊関 雅裕, 水間 正道, 青木 修一, 畠 達夫, 三浦 孝之, 前田 晋平, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 海野 倫明

    膵臓　35　(3)　A114-A114　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  82. 膵全摘術の現状と展望 膵全摘患者のQOL調査 多施設共同前向き研究結果

    亀井 敬子, 松本 逸平, 加藤 宏之, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A115-A115　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  83. 膵全摘術の現状と展望 膵全摘後の脂肪肝発生頻度とそのリスク解析 膵全摘患者に対する前向き実態調査の結果から

    加藤 宏之, 亀井 敬子, 須藤 広誠, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A117-A117　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  84. 膵全摘術の現状と展望 膵全摘術後の糖尿病コントロールと栄養指標の変化について

    須藤 広誠, 亀井 敬子, 加藤 宏之, 三澤 健之, 海野 倫明, 新田 浩幸, 里井 壯平, 川畑 康成, 大塚 将之, 力山 敏樹, 首藤 毅, 松本 逸平, 岡野 圭一, 鈴木 康之, 佐田 尚宏, 伊佐地 秀司, 杉山 政則, 竹山 宜典

    膵臓　35　(3)　A118-A118　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  85. 膵全摘術の現状と展望 National clinical databaseによる膵全摘術の術後重症合併症リスクモデル

    橋本 大輔, 水間 正道, 隈丸 拓, 宮田 裕章, 近本 亮, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 濱田 晋, 水元 一博, 山上 裕機, 山本 雅一, 掛地 吉弘, 瀬戸 泰之, 馬場 秀夫, 海野 倫明, 下瀬川 徹, 岡崎 和一

    膵臓　35　(3)　A119-A119　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  86. 膵癌取り扱い規約変更に関する説明会 第7版増補版改定の要点

    石田 晶玄, 海野 倫明

    膵臓　35　(3)　A122-A122　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  87. 膵癌取り扱い規約変更に関する説明会 膵癌取り扱い規約の手術に関する記載法改定について

    大塚 隆生, 石田 晶玄, 中村 雅史, 海野 倫明, 膵癌取り扱い規約委員会

    膵臓　35　(3)　A125-A125　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  88. 切除可能膵癌に対する術前治療 切除可能膵癌に対する術前化学療法の治療成績

    元井 冬彦, 青木 修一, 畠 達夫, 三浦 孝之, 高館 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 海野 倫明

    膵臓　35　(3)　A144-A144　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  89. p-NEN診療ガイドラインの問題点 腫瘍径が小さい膵神経内分泌腫瘍に対する診断能の検討

    滝川 哲也, 池田 美緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A154-A154　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  90. 切除不能膵癌に対する集学的治療 遠隔転移を有する切除不能膵癌に対する外科的切除の意義

    水間 正道, 元井 冬彦, 林 洋毅, 青木 修一, 畠 達夫, 三浦 孝之, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 亀井 尚, 正宗 淳, 海野 倫明

    膵臓　35　(3)　A182-A182　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  91. 急性膵炎に対する局所合併症治療 内視鏡的ネクロセクトミー後のWONの再発要因について

    粂 潔, 菅野 敦, 池田 未緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A208-A208　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  92. 膵癌のconversion surgery:課題と展望 初診時切除不能膵癌に対する非手術療法奏効後切除の前向き観察研究 Prep-04

    元井 冬彦, 中森 正二, 松本 逸平, 里井 壯平, 平野 聡, 川畑 康成, 庄 雅之, 本田 五郎, 木村 康利, 岸和田 昌之, 青笹 季文, 岡野 圭一, 北川 裕久, 村上 義昭, 海野 倫明

    膵臓　35　(3)　A240-A240　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  93. 膵癌のconversion surgery:課題と展望 局所進行切除不能膵癌に対するconversion Surgery後の早期再発例から切除適応を考える

    林 洋毅, 水間 正道, 畠 達夫, 青木 修一, 高舘 達之, 前田 晋平, 有明 恭平, 川口 桂, 石田 晶玄, 中川 圭, 森川 孝則, 元井 冬彦, 海野 倫明

    膵臓　35　(3)　A243-A243　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  94. 糖尿病関連症状を契機に発見された膵癌患者の臨床学的特徴と予後

    滝川 哲也, 池田 美緒, 佐野 貴紀, 松本 諒太郎, 田中 裕, 鍋島 立秀, 本郷 星仁, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 海野 倫明, 正宗 淳

    膵臓　35　(3)　A270-A270　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  95. 膵頭十二指腸切除後の重症合併症の予測診断における血清プロカルシトニン測定の有用性

    畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 三浦 孝之, 高舘 達之, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 亀井 尚, 海野 倫明

    膵臓　35　(3)　A286-A286　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  96. 洗浄細胞診陽性膵癌に対する化学療法先行治療の有用性

    有明 恭平, 水間 正道, 林 洋毅, 畠 達夫, 青木 修一, 高舘 達之, 三浦 孝之, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 海野 倫明

    膵臓　35　(3)　A302-A302　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  97. 汎用化を目指した腹腔鏡下膵尾側切除術

    森川 孝則, 石田 晶玄, 元井 冬彦, 亀井 尚, 海野 倫明

    膵臓　35　(3)　A335-A335　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  98. 高齢者の膵管内乳頭粘液性腺癌術後5年目に生じた残膵病変に対し残膵全摘を施行した1例

    千葉 和治, 畠 達夫, 水間 正道, 元井 冬彦, 青木 修一, 高舘 達之, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 菅野 敦, 正宗 淳, 大森 優子, 古川 徹, 亀井 尚, 海野 倫明

    膵臓　35　(3)　A402-A402　2020/07

    Publisher: (一社)日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  99. Aortoiliac occlusive disease(AIOD)患者の治療成績と自然予後

    小笠原 紀信, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 高橋 宏和, 内藤 剛, 海野 倫明, 石田 孝宜, 亀井 尚

    日本血管外科学会雑誌　29　(Suppl.)　SF4-4　2020

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

    eISSN： 1881-767X

  100. 内視鏡的ネクロセクトミー後のWONの再発要因について

    粂潔, 池田未緒, 佐野貴紀, 松本諒太郎, 田中裕, 本郷星仁, 滝川哲也, 三浦晋, 濱田晋, 菊田和宏, 海野倫明, 正宗淳

    日本消化器病学会雑誌(Web)　117　2020

    ISSN： 1349-7693

  101. 十二指腸乳頭部原発混合型腺神経内分泌癌(MiNEN)と混合型膵管乳頭粘液性腫瘍(IPMN)の1併存例

    三浦孝之, 中川圭, 林洋毅, 森川孝則, 菅野敦, 大森優子, 古川徹, 元井冬彦, 内藤剛, 亀井尚, 海野倫明

    日本消化器画像診断研究会プログラム・抄録集　72nd　2020

  102. 胆道癌に対する術前・術後補助療法の意義 胆管癌切除例の再発因子と補助化学療法の有用性

    益田 邦洋, 中川 圭, 海野 倫明

    胆道　33　(3)　444-444　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  103. 肝門部領域胆管癌の手術適応と治療戦略

    中川 圭, 益田 邦洋, 吉町 信吾, 青木 修一, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    胆道　33　(3)　510-510　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  104. 胆嚢管に発生したintracholecystic papillary and tubular neoplasm(ICPTN)が総胆管に広範に進展・浸潤した一例

    青木 泰孝, 伊関 雅裕, 高舘 達之, 益田 邦洋, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    胆道　33　(3)　658-658　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  105. 症候性上腸間膜動脈解離症例の検討

    菅原 宏文, 後藤 均, 赤松 大二朗, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 小笠原 紀信, 高橋 宏和, 海野 倫明, 亀井 尚

    脈管学　59　(Suppl.)　S190-S190　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  106. 総大腿動脈(CFA)病変に対する、血栓内膜摘除術の手術成績の検討

    小笠原 紀信, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 高橋 宏和, 内藤 剛, 海野 倫明, 石田 孝宣, 亀井 尚

    脈管学　59　(Suppl.)　S238-S239　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  107. 進行腎細胞癌による下肢動脈腫瘍塞栓の一例

    鈴木 峻也, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 堀井 晋一良, 小笠原 紀信, 高橋 宏和, 亀井 尚, 海野 倫明, 石田 孝宣, 内藤 剛

    脈管学　59　(Suppl.)　S277-S277　2019/10

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

    eISSN： 1880-8840

  108. 膵胆管合流異常を伴う胆嚢Mixed adenoneuroendcrine carcinomaの1例

    佐野 貴紀, 菅野 敦, 田中 裕, 松本 諒太郎, 鍋島 立秀, 滝川 哲也, 三浦 晋, 林 洋毅, 益田 邦洋, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 敦

    胆道　33　(3)　673-673　2019/10

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  109. 術後合併症で苦しんだ症例2(下部消化管) 血栓性微小血管障害症を合併し治療に難渋したS状結腸癌の1例

    唐澤 秀明, 大沼 忍, 梶原 大輝, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　80　(増刊)　413-413　2019/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  110. Adjuvant and neoadjuvant therapy for pancreatic cancer

    Shimpei Maeda, Michiaki Unno, Jun Yu

    Journal of Pancreatology　2　(3)　100-106　2019/09/01

    Publisher: Wolters Kluwer Health

    DOI： 10.1097/JP9.0000000000000028 　

    ISSN： 2577-3577 2096-5664

  111. 晩期合併症・トランジション 先天性胆道拡張症術後肝内結石に対する治療

    大塚 英郎, 畠 達夫, 青木 修一, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　42　33-33　2019/09

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  112. 血液型不適合肝臓移植の現状と課題 心停止ドナー肝グラフトの臓器再生の現状と展望

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　184-184　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  113. 肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

    佐々木 健吾, 宮城 重人, 笹嶋 秀憲, 宮崎 勇希, 藤尾 淳, 西村 隆一, 中西 渉, 戸子台 和哲, 大田 英揮, 高瀬 圭, 亀井 尚, 海野 倫明

    移植　54　(総会臨時)　200-200　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  114. 補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響

    戸子台 和哲, 宮城 重人, 中西 渉, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　54　(総会臨時)　226-226　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  115. エコー上指摘された生体肝移植後早期門脈ガス像の臨床的意義

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 藤尾 淳, 佐々木 健吾, 宮崎 勇希, 笹嶋 秀憲, 内藤 剛, 海野 倫明, 後藤 昌史, 亀井 尚

    移植　54　(総会臨時)　290-290　2019/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  116. 低侵襲細胞移植療法の確立を目的とした羊膜上皮細胞分離体制の構築

    戸子台和哲, 伊藤貴子, 沖田ひとみ, 齋藤昌利, 星合哲郎, 山田修平, 宮城重人, 海野倫明, 亀井尚, 後藤昌史, 後藤昌史

    日本組織移植学会雑誌　18　(1)　44　2019/07/05

    ISSN： 1347-6491

  117. 胆膵悪性疾患に対する膵頭十二指腸切除

    中川 圭, 益田 邦洋, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　P203-6　2019/07

    Publisher: (一社)日本消化器外科学会

  118. 【肝胆膵】肝内胆管癌:肝内胆管癌切除における至適リンパ節郭清 リンパ節郭清及び胆管切除が肝内胆管癌の予後に与える影響

    益田 邦洋, 中川 圭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　WS30-6　2019/07

    Publisher: (一社)日本消化器外科学会

  119. 短期間で形態変化を認めた膵腺房細胞癌の1例

    池田 未緒, 三浦 晋, 佐野 貴紀, 田中 裕, 松本 諒太郎, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 菊田 和宏, 濱田 晋, 粂 潔, 菅野 敦, 畠 達夫, 元井 冬彦, 海野 倫明, 大森 優子, 古川 徹, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　207回　50-50　2019/07

    Publisher: 日本消化器病学会-東北支部

  120. 腹腔鏡下幽門側胃切除における予後規定因子の検討

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　P56-7　2019/07

    Publisher: (一社)日本消化器外科学会

  121. 進行消化管癌は癌関連DICを引き起こすか

    山村 明寛, 武者 宏昭, 大沼 忍, 田中 直樹, 渡辺 和宏, 青木 豪, 神山 篤史, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P276-1　2019/07

    Publisher: (一社)日本消化器外科学会

  122. 当科における腹壁瘢痕ヘルニアに対する治療戦略

    青木 豪, 井本 博文, 山村 明寛, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P262-2　2019/07

    Publisher: (一社)日本消化器外科学会

  123. 減量手術における術前減量の効果の検討

    田中 直樹, 井本 博文, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　74回　P41-4　2019/07

    Publisher: (一社)日本消化器外科学会

  124. 当院における病的肥満症に対する減量手術の治療成績と治療戦略

    井本 博文, 田中 直樹, 山村 明寛, 青木 豪, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器外科学会総会　74回　O52-3　2019/07

    Publisher: (一社)日本消化器外科学会

  125. 高度心機能低下を有するWilson病患者に対し、肝移植後、大動脈内バルーンパンピングを使用し救命した一例

    佐々木 健吾, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P195-4　2019/07

    Publisher: (一社)日本消化器外科学会

  126. 腎機能障害を有する患者の周術期管理 Chronic kidney diseaseを伴う肝細胞癌患者に対する肝切除術 周術期合併症への影響

    西村 隆一, 宮城 重人, 戸子台 和哲, 中西 渉, 藤尾 淳, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　WS16-7　2019/07

    Publisher: (一社)日本消化器外科学会

  127. 小児生体肝移植術後の晩期門脈合併症に対する治療戦略

    藤尾 淳, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　P198-6　2019/07

    Publisher: (一社)日本消化器外科学会

  128. 胆道閉鎖症葛西術後キャリーオーバー症例を含む、複数開腹歴のある症例に対する肝移植

    宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 福岡 健吾, 佐々木 健吾, 柿崎 裕太, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　74回　O22-2　2019/07

    Publisher: (一社)日本消化器外科学会

  129. 臨床外科医ができる動物移植モデルを使った基礎研究

    山田 修平, 柿崎 裕太, 宮城 重人, 戸子台 和哲, 中西 渉, 西村 隆一, 藤尾 淳, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　74回　RS36-6　2019/07

    Publisher: (一社)日本消化器外科学会

  130. 膀胱浸潤大腸癌に対する機能温存と根治性を求めた治療戦略

    唐澤 秀明, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　74回　P142-1　2019/07

    Publisher: (一社)日本消化器外科学会

  131. 肝硬変を合併した特発性食道破裂に対し胸腔鏡下に一期的縫合閉鎖を行い救命し得た1例

    鳩山 恵一朗, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 岡本 宏史, 今野 卓, 氏家 直人, 海野 倫明, 亀井 尚

    日本食道学会学術集会プログラム・抄録集　73回　206-206　2019/06

    Publisher: (NPO)日本食道学会

  132. MCN疑い病変の取扱い-経過観察可能な病変はあるか? Mucinous cystic neoplasmsの術前診断能と良悪性診断に関する検討

    三浦 晋, 菅野 敦, 松本 裕, 松本 遼太郎, 本郷 星仁, 滝川 哲也, 濱田 晋, 菊田 和宏, 粂 潔, 元井 冬彦, 海野 倫明, 正宗 淳

    膵臓　34　(3)　A78-A78　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  133. 膵神経内分泌腫瘍の切除適応と切除範囲 非機能性膵神経内分泌腫瘍における悪性因子と長期予後に関する検討

    滝川 哲也, 菅野 敦, 松本 諒太郎, 田中 裕, 本郷 星仁, 鍋島 立秀, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 中川 圭, 元井 冬彦, 海野 倫明, 正宗 淳

    膵臓　34　(3)　A83-A84　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  134. MCN疑い病変の取扱い-経過観察可能な病変はあるか? Mucinous cystic neoplasmsの術前診断能と良悪性診断に関する検討

    三浦 晋, 菅野 敦, 松本 裕, 松本 遼太郎, 本郷 星仁, 滝川 哲也, 濱田 晋, 菊田 和宏, 粂 潔, 元井 冬彦, 海野 倫明, 正宗 淳

    膵臓　34　(3)　A78-A78　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  135. 膵神経内分泌腫瘍の切除適応と切除範囲 非機能性膵神経内分泌腫瘍における悪性因子と長期予後に関する検討

    滝川 哲也, 菅野 敦, 松本 諒太郎, 田中 裕, 本郷 星仁, 鍋島 立秀, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 中川 圭, 元井 冬彦, 海野 倫明, 正宗 淳

    膵臓　34　(3)　A83-A84　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  136. 膵癌術前治療後のγStageに関する検討

    水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    膵臓　34　(3)　A275-A275　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  137. 膵頭十二指腸切除周術期における亜鉛欠乏症

    伊関 雅裕, 水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 正宗 淳, 海野 倫明

    膵臓　34　(3)　A285-A285　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  138. ストーマ脱の還納、浮腫腸管のストーマ造設における高浸透圧を利用したslug法(ナメクジ法)の手技

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　35　(2)　45-45　2019/06

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  139. 腸型IPMNはどのように発生するか? CDX2、MUC2、alcian blue三重染色による検討

    大森 優子, 水上 裕輔, 元井 冬彦, 海野 倫明, 古川 徹

    膵臓　34　(3)　A169-A169　2019/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  140. クローン病の直腸肛門部癌症例の特徴について とくに術前CEA値の有用性についての考察

    渡辺 和宏, 長尾 宗紀, 大沼 忍, 唐澤 秀明, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　255-255　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  141. 大腸癌における術前血清p53抗体測定の臨床的意義の検討

    初沢 悠人, 小野 智之, 唐澤 秀明, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　256-256　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  142. BMI 25以上の結腸癌に対する腹腔鏡手術

    小野 智之, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　280-280　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  143. StageII大腸癌の治療成績および危険因子の検討

    平嶋 倫亮, 大沼 忍, 村上 恵, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　297-297　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  144. 大腸癌切除症例の占拠部位による治療成績

    小野 智之, 大沼 忍, 村上 恵, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　302-302　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  145. 手術治療を施した原発性小腸癌9例の検討

    小久保 翔志, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　341-341　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  146. 大腸SM癌のリンパ節転移リスク因子に関する検討

    鈴木 ゆき恵, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　72　(5)　358-358　2019/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  147. 人工知能がもたらす外科の将来像 機械学習の外科臨床への応用

    石田 晶玄, 森川 孝則, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　WS-20　2019/04

    Publisher: (一社)日本外科学会

  148. 進行膵癌に対する腹腔動脈合併切除兼尾側膵切除(DP-CAR)の適応と意義

    元井 冬彦, 伊関 雅裕, 三浦 孝之, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 石田 孝宣, 亀井 尚, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-002　2019/04

    Publisher: (一社)日本外科学会

  149. 膵癌肝転移に対する肝切除の適応

    伊関 雅裕, 森川 孝則, 畠 達夫, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-017　2019/04

    Publisher: (一社)日本外科学会

  150. 膵癌におけるBACH1の機能

    佐藤 正規, 大塚 英郎, 松本 光代, 齋木 由利子, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-065　2019/04

    Publisher: (一社)日本外科学会

  151. アミノ酸プロファイルに基づく膵良悪性疾患鑑別因子の検討

    川口 桂, 水間 正道, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高館 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-067　2019/04

    Publisher: (一社)日本外科学会

  152. 膵癌細胞株における放射線照射によるdCK活性増加を介したGEM感受性亢進作用の解明

    高橋 裕季, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-065　2019/04

    Publisher: (一社)日本外科学会

  153. 当院における原発性十二指腸癌13例の臨床病理学的検討

    三田地 克昂, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-083　2019/04

    Publisher: (一社)日本外科学会

  154. 細胞診陽性切除可能膵癌に対するコンバージョン切除を企図した取り組み

    有明 恭平, 水間 正道, 元井 冬彦, 林 洋毅, 中川 圭, 大塚 英郎, 石田 晶玄, 益田 邦洋, 川口 桂, 高館 達之, 三浦 孝之, 伊関 雅裕, 畠 達夫, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-093　2019/04

    Publisher: (一社)日本外科学会

  155. 肝門部領域胆管癌の至適手術適応の検討

    中川 圭, 益田 邦洋, 高舘 達之, 伊関 雅裕, 畠 達夫, 三浦 孝之, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 宮城 重人, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-119　2019/04

    Publisher: (一社)日本外科学会

  156. 遠位胆管癌の治療成績と補助化学療法の有用性

    益田 邦洋, 中川 圭, 畠 達夫, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 石田 晶玄, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-120　2019/04

    Publisher: (一社)日本外科学会

  157. 膵頭十二指腸切除術後の膵液瘻に対する感染対策 ドレーン検査と炎症反応による早期診断と治療介入の応用性

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-195　2019/04

    Publisher: (一社)日本外科学会

  158. 当院における原発性十二指腸癌13例の臨床病理学的検討

    三田地 克昂, 大塚 英郎, 三浦 孝之, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-083　2019/04

    Publisher: (一社)日本外科学会

  159. 経口摂取可能食道癌患者における術前治療中の栄養評価

    日景 允, 谷山 裕亮, 櫻井 直, 佐藤 千晃, 高屋 快, 岡本 宏史, 氏家 直人, 今野 卓朗, 内藤 剛, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-050　2019/04

    Publisher: (一社)日本外科学会

  160. 当院の食道癌術後再発症例に対する治療の検討

    岡本 宏史, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 今野 卓朗, 氏家 直人, 内藤 剛, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-122　2019/04

    Publisher: (一社)日本外科学会

  161. ロボット支援下食道切除術の導入時における問題点と対処法

    谷山 裕亮, 桜井 直, 日景 允, 岡本 宏史, 佐藤 千晃, 高屋 快, 今野 卓郎, 氏家 直人, 内藤 剛, 石田 孝宣, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-221　2019/04

    Publisher: (一社)日本外科学会

  162. 多職種介入によるNSTの現状と問題点

    中西 渉, 宮城 重人, 戸子台 和哲, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-012　2019/04

    Publisher: (一社)日本外科学会

  163. 当科における12歳未満の小児生体肝移植の成績について

    藤尾 淳, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 西村 隆一, 佐々木 健吾, 福岡 健吾, 熊田 博之, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-088　2019/04

    Publisher: (一社)日本外科学会

  164. 非アルコール性脂肪性肝炎を背景とした微小肝細胞がんの高精度検出および高感度病理解析

    太田 嶺人, 宇根 範和, 西村 隆一, 宮城 重人, 海野 倫明, 権田 幸祐

    肝臓　60　(Suppl.1)　A464-A464　2019/04

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

  165. 下腿単独病変による重症虚血肢における治療の課題

    赤松 大二朗, 後藤 均, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 内藤 剛, 海野 倫明, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　SF-042　2019/04

    Publisher: (一社)日本外科学会

  166. 非解剖学的上腸間膜バイパスを施行した13例の検討

    濱田 庸, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 海野 倫明, 内藤 剛, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-144　2019/04

    Publisher: (一社)日本外科学会

  167. 超常磁性酸化鉄造影剤を用いた核磁気共鳴画像法による腹部大動脈瘤の中膜および外膜内の組織マクロファージの局在評価

    梅津 道久, 後藤 均, 赤松 大二朗, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 内藤 剛, 石田 孝宜, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-148　2019/04

    Publisher: (一社)日本外科学会

  168. 下腿単独病変による重症虚血肢における治療の課題

    赤松 大二朗, 後藤 均, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 内藤 剛, 海野 倫明, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　SF-042　2019/04

    Publisher: (一社)日本外科学会

  169. 非解剖学的上腸間膜バイパスを施行した13例の検討

    濱田 庸, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 海野 倫明, 内藤 剛, 石田 孝宣, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-144　2019/04

    Publisher: (一社)日本外科学会

  170. 超常磁性酸化鉄造影剤を用いた核磁気共鳴画像法による腹部大動脈瘤の中膜および外膜内の組織マクロファージの局在評価

    梅津 道久, 後藤 均, 赤松 大二朗, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 内藤 剛, 石田 孝宜, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　119回　PS-148　2019/04

    Publisher: (一社)日本外科学会

  171. 全国大学医学部における卒前のキャリア教育による早期啓発講義の調査報告

    佐藤 章子, 多田 寛, 宮下 穣, 原田 成美, 濱中 洋平, 藤井 里圭, 福與 なおみ, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　119回　SP-1　2019/04

    Publisher: (一社)日本外科学会

  172. 術前薬物療法後の乳癌の外科治療:切除範囲,センチネルリンパ節生検の適応,再建方法 乳癌に対するネオアジュバント化学療法後の残存病変の評価(Evaluation of remaining lesion after neo-adjuvant chemotherapy for breast cancer)

    濱中 洋平, 多田 寛, 宮下 穣, 原田 成美, 佐藤 章子, 藤井 里圭, 森 菜緒子, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　119回　SY-14　2019/04

    Publisher: (一社)日本外科学会

  173. 乳癌ゲノム医療の推進に向けた取り組み 東北大学における乳癌ゲノム医療への取り組み

    多田 寛, 宮下 穣, 原田 成美, 佐藤 章子, 濱中 洋平, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　119回　WS-17　2019/04

    Publisher: (一社)日本外科学会

  174. 進行膵癌に対する腹腔動脈合併切除兼尾側膵切除(DP-CAR)の適応と意義

    元井 冬彦, 伊関 雅裕, 三浦 孝之, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 石田 孝宣, 亀井 尚, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-1　2019/04

    Publisher: (一社)日本外科学会

  175. National clinical database(NCD)による膵全摘術の術後合併症リスクモデル

    橋本 大輔, 水間 正道, 隈丸 拓, 宮田 裕章, 近本 亮, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壮平, 濱田 晋, 水元 一博, 山上 裕機, 山本 雅一, 掛地 吉弘, 瀬戸 泰之, 馬場 秀夫, 海野 倫明, 下瀬川 徹, 岡崎 和一

    日本外科学会定期学術集会抄録集　119回　SF-2　2019/04

    Publisher: (一社)日本外科学会

  176. National Clinical Database(NCD)膵癌登録の第1回予後調査

    水間 正道, 海野 倫明, 隈丸 拓, 宮田 裕章, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壮平, 濱田 晋, 水元 一博, 掛地 吉弘, 瀬戸 泰之, 下瀬川 徹, 岡崎 和一

    日本外科学会定期学術集会抄録集　119回　SF-1:[P]　2019/04

    Publisher: (一社)日本外科学会

  177. Affibodyの新規18F標識法によるHER2、PD-L1発現腫瘍の分子イメージング

    谷内 亜衣, 原田 龍一, 岩田 錬, 吉川 雄朗, 古本 祥三, 谷内 一彦, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宜

    日本外科学会定期学術集会抄録集　119回　PS-3　2019/04

    Publisher: (一社)日本外科学会

  178. Affibodyの新規18F標識法によるHER2、PD-L1発現腫瘍の分子イメージング

    谷内 亜衣, 原田 龍一, 岩田 錬, 吉川 雄朗, 古本 祥三, 谷内 一彦, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宜

    日本外科学会定期学術集会抄録集　119回　PS-110　2019/04

    Publisher: (一社)日本外科学会

  179. 各臓器癌の肝転移に対する手術的治療(Conversionを含む) 神経内分泌腫瘍肝転移に関する外科的転帰 日本における後向き多施設共同調査(Surgical outcomes for neuroendocrine liver metastases:A retrospective, multicenter survey in japan)

    青木 琢, 窪田 敬一, 國土 典宏, 桐谷 翔, 有田 淳一, 森実 千種, 増井 俊彦, 河本 泉, 波多野 悦朗, 伊藤 鉄英, 長村 義之, 海野 倫明, 上本 伸二, 日本神経内分泌腫瘍研究会

    日本外科学会定期学術集会抄録集　119回　SY-1　2019/04

  180. 膵癌間質プロテオミクスによる新規リンパ節転移関連因子ヘモペキシンの発見

    鈴木 ゆき恵, 高館 達之, 水間 正道, 島 弘季, 鈴木 貴, 橘 知睦, 志村 充広, 畠 達夫, 伊関 雅裕, 川口 桂, 青木 豪, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-063　2019/04

    Publisher: (一社)日本外科学会

  181. 乳癌におけるアミノ酸トランスポーターの発現と治療による変化

    佐藤 未来, 原田 成美, 宮下 穰, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣, 鈴木 貴, 笹野 公伸

    日本外科学会定期学術集会抄録集　119回　PS-110　2019/04

    Publisher: (一社)日本外科学会

  182. 癌関連線維芽細胞はWnt2を介して大腸癌の進展を制御する

    相澤 卓, 唐澤 秀明, 鈴木 秀幸, 山村 明寛, 大沼 忍, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-020　2019/04

    Publisher: (一社)日本外科学会

  183. 術前化学療法が著効し骨盤内臓全摘を回避し得た膀胱浸潤直腸癌の1切除例

    望月 保志, 唐澤 秀明, 宇根 範和, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　46　(4)　820-822　2019/04

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  184. 炎症性腸疾患に対する外科治療の成績と方向性 生物学的製剤導入後の潰瘍性大腸炎に対する外科治療の時代的変化

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SY-17　2019/04

    Publisher: (一社)日本外科学会

  185. クローン病手術症例の複数回の再手術率および腸管不全の発症例についての検討

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 青木 豪, 井本 博文, 山村 明寛, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-023　2019/04

    Publisher: (一社)日本外科学会

  186. 高齢者に対する腹腔鏡下幽門側胃切除術の治療成績

    武者 宏昭, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 山村 明寛, 青木 豪, 神山 篤史, 田中 直樹, 渡辺 和宏, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-029　2019/04

    Publisher: (一社)日本外科学会

  187. 十二指腸空腸バイパス手術における胆膵路の長さの違いが代謝に及ぼす影響とその機序の検討

    伊勢 一郎, 田中 直樹, 井本 博文, 前川 正充, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-035　2019/04

    Publisher: (一社)日本外科学会

  188. 直腸癌局所再発に対する手術療法の問題点と治療戦略

    大沼 忍, 唐澤 秀明, 神山 篤史, 鈴木 秀幸, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-088　2019/04

    Publisher: (一社)日本外科学会

  189. 直腸癌の病期診断におけるMRIの有用性

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 神山 篤史, 鈴木 秀幸, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　SF-090　2019/04

    Publisher: (一社)日本外科学会

  190. 腹腔鏡下スリーブ状胃切除術の手術手技とピットフォール

    井本 博文, 田中 直樹, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 石田 孝宣, 海野 倫明, 内藤 剛

    日本外科学会定期学術集会抄録集　119回　PS-028　2019/04

    Publisher: (一社)日本外科学会

  191. 当科におけるLECS(腹腔鏡内視鏡合同手術)の治療成績と早期胃癌へのアプローチ

    青木 豪, 井本 博文, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-028　2019/04

    Publisher: (一社)日本外科学会

  192. 胃全摘後のビタミンB12サーベイランスと経口薬による補充療法

    田中 直樹, 武者 宏昭, 青木 豪, 山村 明寛, 井本 博文, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 亀井 尚, 元井 冬彦, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-047　2019/04

    Publisher: (一社)日本外科学会

  193. 一般向け物理エンジンを用いた流体シミュレーションの消化器外科分野への応用

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 大沼 忍, 田中 直樹, 青木 豪, 山村 明寛, 井本 博文, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　119回　PS-188　2019/04

    Publisher: (一社)日本外科学会

  194. 甲状腺髄様癌が傍神経節腫に腫瘍内転移したMEN2Bの一例

    菖野佳浩, 戸子台和哲, 西村隆一, 中西渉, 藤尾淳, 佐々木健吾, 福岡健吾, 柿崎裕太, 宮城重人, 亀井尚, 石田孝宣, 海野倫明, 山崎有人, 笹野公伸

    日本内分泌学会雑誌　95　(1)　497　2019/04/01

    ISSN： 0029-0661

  195. 膵頭部癌における血清亜鉛値の検討

    水間 正道, 伊関 雅裕, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 正宗 淳, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A381-A381　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  196. 内視鏡治療後に追加切除を行った直腸神経内分泌腫瘍症例の検討

    大沼 忍, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 渡辺 和宏, 鈴木 ゆき恵, 金原 圭吾, 伊勢 一郎, 相澤 卓, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　116　(臨増総会)　A360-A360　2019/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  197. 当科で経験した特発性食道破裂症例13例の検討

    高屋 快, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 岡本 宏史, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本腹部救急医学会雑誌　39　(2)　364-364　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  198. 目指せ!消化器病専門医-後期研修医からの報告 dCRT後の瘢痕狭窄部遠位に生じた異時性再発食道癌に対し、経胃瘻的にPDTを施行した1例

    安藤 涼平, 櫻井 直, 小関 健, 氏家 直人, 今野 卓朗, 岡本 宏史, 高屋 快, 佐藤 千晃, 日景 充, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　206回　68-68　2019/02

    Publisher: 日本消化器病学会-東北支部

  199. Heller-Dor術後の食道アカラシア症残存胸痛に対しPOEMを施行した1例

    佐藤 千晃, 櫻井 直, 谷山 裕亮, 日景 允, 高屋 快, 岡本 宏史, 今野 卓朗, 氏家 直人, 小関 健, 安藤 涼平, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　206回　85-85　2019/02

    Publisher: 日本消化器病学会-東北支部

  200. 当科で経験した特発性食道破裂症例13例の検討

    高屋 快, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 岡本 宏史, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本腹部救急医学会雑誌　39　(2)　364-364　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  201. 目指せ!消化器病専門医-後期研修医からの報告 dCRT後の瘢痕狭窄部遠位に生じた異時性再発食道癌に対し、経胃瘻的にPDTを施行した1例

    安藤 涼平, 櫻井 直, 小関 健, 氏家 直人, 今野 卓朗, 岡本 宏史, 高屋 快, 佐藤 千晃, 日景 充, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　206回　68-68　2019/02

    Publisher: 日本消化器病学会-東北支部

  202. Heller-Dor術後の食道アカラシア症残存胸痛に対しPOEMを施行した1例

    佐藤 千晃, 櫻井 直, 谷山 裕亮, 日景 允, 高屋 快, 岡本 宏史, 今野 卓朗, 氏家 直人, 小関 健, 安藤 涼平, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　206回　85-85　2019/02

    Publisher: 日本消化器病学会-東北支部

  203. 一期的に手術し得た維持透析患者への胸腔鏡下食道切除術5例の検討

    今野 卓朗, 谷山 裕亮, 櫻井 直, 日景 允, 佐藤 千晃, 高屋 快, 岡本 宏史, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器病学会東北支部例会プログラム・抄録集　206回　86-86　2019/02

    Publisher: 日本消化器病学会-東北支部

  204. 内臓動脈疾患の診断と治療戦略 孤立性上腸間膜動脈解離12例の検討

    菅原 宏文, 後藤 均, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　322-322　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  205. 内臓動脈疾患の診断と治療戦略 上腸間膜動脈バイパス術の手術手技と成績

    赤松 大二朗, 後藤 均, 海野 倫明, 内藤 剛, 亀井 尚

    日本腹部救急医学会雑誌　39　(2)　323-323　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  206. 感染性腹部大動脈瘤の術中主膵管損傷による術後膵液瘻に対して瘻孔空腸吻合術を施行した1例

    遠山 慎吾, 水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 益田 邦洋, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 土田 憲, 赤松 大二朗, 後藤 均, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　432-432　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  207. 自己免疫性膵炎の維持療法中に膵上皮内癌の発生が疑われ、膵体尾部切除術を施行した1例

    松本 諒太郎, 菅野 敦, 田中 裕, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 石田 晶玄, 元井 冬彦, 海野 倫明, 藤島 史喜, 大森 優子, 古川 徹, 正宗 淳

    日本消化器病学会東北支部例会プログラム・抄録集　206回　75-75　2019/02

    Publisher: 日本消化器病学会-東北支部

  208. 急性膵炎に続発した慢性巨大結腸症

    佐藤 英昭, 石田 晶玄, 長尾 宗紀, 田中 直樹, 大沼 忍, 大塚 英郎, 水間 正道, 武者 宏昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　431-431　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  209. 消化器疾患の診断と治療戦略 消化管の部 病的肥満症・糖尿病に対する外科治療 減量手術からmetabolic surgeryへ

    井本 博文, 田中 直樹, 亀井 尚, 海野 倫明, 内藤 剛

    日本消化器病学会東北支部例会プログラム・抄録集　206回　48-48　2019/02

    Publisher: 日本消化器病学会-東北支部

  210. 炎症性腸疾患に対する緊急処置-外科的介入と問題点- 潰瘍性大腸炎手術例の時代的変化

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　326-326　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  211. 炎症性腸疾患に対する緊急処置-外科的介入と問題点- 回腸嚢炎に対する緊急処置の検討

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　328-328　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  212. 高度肥満(BMI=50)により周術期管理に苦慮した消化管出血を伴う盲腸癌の1例

    田山 穂高, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　365-365　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  213. 下血と穿孔を繰り返し剖検でサイトメガロウイルス腸炎と診断された多発小腸潰瘍の1例

    上野 知尭, 井本 博文, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 青木 豪, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　365-365　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  214. 閉塞性大腸癌に対する人工肛門造設術の検討

    鈴木 ゆき恵, 唐澤 秀明, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　374-374　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  215. 水腎症を呈した膀胱全摘術後の絞扼性腸閉塞の1例

    相澤 卓, 山村 明寛, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 青木 豪, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　404-404　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  216. 大腸壊死に伴う多発消化管穿孔の1例

    初沢 悠人, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　413-413　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  217. 手術を要した腸管型ベーチェット病の長期予後の検討

    伊勢 一郎, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　414-414　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  218. 肺塞栓症術後、抗凝固療法にて血栓消失し、横行結腸癌手術を行った1例

    青木 泰孝, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　456-456　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  219. 病的肥満に対するLaparoscopic sleeve gastrectomy(LSG)後の狭窄に対して、バルーン拡張術後に腹腔内出血を来した1例

    市川 英孝, 井本 博文, 田中 直樹, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　459-459　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  220. 閉塞性右側結腸癌に対する腹腔鏡下手術の検討

    金原 圭吾, 唐澤 秀明, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　463-463　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  221. 急速な全身状態悪化を招いた転移性卵巣腫瘍破裂に対して外科的切除が有効であったS状結腸癌卵巣転移の1例

    佐藤 圭佑, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 武者 宏昭, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　39　(2)　463-463　2019/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  222. 肺転移を来したHead invasionと病理学的に診断された大腸SM癌の2例

    佐藤 圭佑, 大沼 忍, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 佐藤 聡子, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会東北支部例会プログラム・抄録集　206回　94-94　2019/02

    Publisher: 日本消化器病学会-東北支部

  223. 膵腎同時移植後の血管合併症と対策

    宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 福岡健吾, 柿崎裕太, 笹嶋秀憲, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　46th　52　2019/02

  224. 脂肪由来幹細胞を付加したリコンビナントペプチドの導入による新規皮下膵島移植法の開発

    水井崇浩, 稲垣明子, 中村保宏, IBRAHIM Fathi, 猪村武弘, 植松智海, 宮城重人, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　46th　61　2019/02

  225. 免疫抑制剤不要の次世代膵島移植実現へ向けた試み

    後藤昌史, 後藤昌史, 稲垣明子, 猪村武弘, IBRAHIM Fathi, 水井崇浩, 金井哲史, 戸子台和哲, 宮城重人, 村山和隆, 亀井尚, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　46th　2019

  226. 直腸癌局所再発に対する手術療法の現状と問題点

    大沼忍, 唐澤秀明, 鈴木秀幸, 神山篤史, 渡辺和宏, 内藤剛, 海野倫明

    日本大腸肛門病学会雑誌(Web)　72　(9)　2019

    ISSN： 1882-9619

  227. 膵癌の長期予後に術後合併症が及ぼす影響

    水間正道, 元井冬彦, 林洋毅, 畠達夫, 伊関雅裕, 高舘達之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 内藤剛, 亀井尚, 菅野敦, 正宗淳, 海野倫明

    日本消化器外科学会雑誌(Web)　52　(Supplement2)　2019

    ISSN： 1348-9372

  228. クローン病の腸管不全例の予防/治療における専門領域での連携

    渡辺和宏, 神山篤史, 鈴木秀幸, 唐澤秀明, 大沼忍, 武者宏昭, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    日本大腸肛門病学会雑誌(Web)　72　(9)　2019

    ISSN： 1882-9619

  229. ストーマサイトとストーマ関連腸閉塞の関連性

    鈴木秀幸, 渡辺和宏, 神山篤史, 大沼忍, 唐澤秀明, 武者宏昭, 田中直樹, 青木豪, 山村明寛, 井本博文, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    日本消化器外科学会雑誌(Web)　52　(Supplement2)　2019

    ISSN： 1348-9372

  230. 高齢者潰瘍性大腸炎の外科治療の特徴と治療成績

    神山篤史, 渡辺和宏, 鈴木秀幸, 唐澤秀明, 大沼忍, 内藤剛, 海野倫明

    日本大腸肛門病学会雑誌(Web)　72　(9)　2019

    ISSN： 1882-9619

  231. 周術期栄養状態の変化からみた高齢者に対する膵全摘

    伊関雅裕, 水間正道, 畠達夫, 高舘達之, 有明恭平, 川口桂, 益田邦洋, 石田晶玄, 大塚英郎, 中川圭, 林洋毅, 森川孝則, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    日本消化器外科学会雑誌(Web)　52　(Supplement2)　2019

    ISSN： 1348-9372

  232. 多領域に血栓が充満したVTEに対する血管内治療の役割

    梅津 道久, 後藤 均, 赤松 大二朗, 菅原 宏文, 濱田 庸, 土田 憲, 吉田 良太朗, 鈴木 峻也, 堀井 晋一良, 小笠原 紀信, 海野 倫明, 亀井 尚

    日本血管外科学会雑誌　28　(Suppl.)　O9-4　2019

    Publisher: (NPO)日本血管外科学会

    ISSN： 0918-6778

  233. 女性外科医のキャリアパス 女性医師支援の現状把握と今後の展望

    佐藤 章子, 多田 寛, 渡部 剛, 原田 成美, 宮下 穣, 濱中 洋平, 藤井 里圭, 柳垣 美歌, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会雑誌　120　(1)　114-116　2019/01

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  234. 手術手技 ストーマ脱・直腸脱の還納,浮腫腸管のストーマ造設における高浸透圧を利用したナメクジ法(slug method)の手技

    渡辺 和宏, 内藤 剛, 神山 篤史, 渡邊 涼子, 亀井 尚, 海野 倫明

    手術　73　(1)　83-87　2019/01

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  235. Stoma outlet obstructionの現状と対策 大腸全摘術後Stoma Outlet Obstructionの危険因子の検討

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 高橋 真紀, 内藤 剛, 亀井 尚, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　35　(1)　123-123　2019/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  236. ストーマサイトマーキング位置推測に有用な指標の探求

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 大沼 忍, 武者 宏昭, 渡邊 涼子, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　35　(1)　208-208　2019/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  237. 潰瘍性大腸炎術後に著明な腸管拡張を呈したafferent limb syndromeに対してストーマ造設を行なった2例

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 武者 宏昭, 渡邊 涼子, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　35　(1)　266-266　2019/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  238. 肝・膵粘液性嚢胞腫瘍における卵巣様間質でのステロイドホルモン合成動態についての免疫組織化学的検討

    熊田博之, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

    日本外科学会定期学術集会(Web)　119th　ROMBUNNO.PS‐177‐1 (WEB ONLY)　2019

  239. 進行肝門部胆管癌に対する動門脈合併切除の成績及び血管内皮保護を目的とした超音波モニタリング術後管理法の有用性

    宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 熊田博之, 佐々木健吾, 中川圭, 森川孝則, 元井冬彦, 内藤剛, 石田孝宣, 力山敏樹, 亀井尚, 海野倫明

    日本外科学会定期学術集会(Web)　119th　ROMBUNNO.SF‐008‐1:(P) (WEB ONLY)　2019

  240. 生体肝移植におけるMELDを含む術前因子と予後の検討

    中西史, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 後藤昌史, 内藤剛, 海野倫明, 石田孝宣, 亀井尚

    日本外科学会定期学術集会(Web)　119th　ROMBUNNO.PS‐087‐2 (WEB ONLY)　2019

  241. Chronic kidney diseaseを併せもつ肝細胞癌症例に対するanatomical resectionとnon‐anatomical resectionの比較検討

    西村隆一, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 福岡健吾, 内藤剛, 石田孝宣, 海野倫明, 亀井尚

    日本外科学会定期学術集会(Web)　119th　ROMBUNNO.PS‐075‐4 (WEB ONLY)　2019

  242. 慢性抗体関連型拒絶の病理像を呈しDPにのみDSAを認めた1例

    福岡健吾, 戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 柿崎裕太, 海野倫明, 亀井尚

    日本臨床腎移植学会プログラム・抄録集　52nd　254　2019

  243. 1型糖尿病根治のための当施設のストラテジー―膵臓移植短期合併症の克服と低侵襲細胞治療の成績向上―

    戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 内藤剛, 石田孝宣, 後藤昌史, 海野倫明, 亀井尚

    日本外科学会定期学術集会(Web)　119th　ROMBUNNO.SF‐054‐5 (WEB ONLY)　2019

  244. 脂肪由来幹細胞を付加したリコンビナントペプチドの移植前留置による皮下膵島移植法の至適化

    水井崇浩, 稲垣明子, 中村保宏, FATHI Ibrahim, 猪村武弘, 植松智海, 宮城重人, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

    日本再生医療学会総会(Web)　18th　ROMBUNNO.O‐33‐1 (WEB ONLY)　2019

  245. 腹腔鏡下肝切除術の定型化に向けたチームでの取り組み

    高舘 達之, 森川 孝則, 石田 晶玄, 畠 達夫, 伊関 雅裕, 三浦 孝之, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS222-1　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  246. 肥満外科治療の現状と展望 腹腔鏡下スリーブバイパス術の糖尿病改善機序とその効果

    内藤 剛, 田中 直樹, 井本 博文, 青木 豪, 山村 明寛, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　SY10-5　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  247. 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除術の手技および長期成績

    武者 宏昭, 井本 博文, 青木 豪, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS202-4　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  248. 術前化学放射線療法が著効し腹腔鏡下に根治切除し得た巨大直腸癌の1例

    相澤 卓, 唐澤 秀明, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　45　(13)　1931-1933　2018/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  249. 直腸癌術後の局所再発に対し重粒子線治療が奏効した2例

    金原 圭吾, 大沼 忍, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　45　(13)　1940-1942　2018/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  250. リンパ節転移を認めた長径5mmの直腸神経内分泌腫瘍の1例

    小久保 翔志, 大沼 忍, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　45　(13)　1985-1987　2018/12

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  251. 肥満外科手術のコツ 当院における腹腔鏡下スリーブ・バイパス術の手術手技

    井本 博文, 田中 直樹, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 青木 豪, 神山 篤史, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明, 内藤 剛

    日本内視鏡外科学会雑誌　23　(7)　WS17-6　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  252. ヒヤリハットとその対応(消化器) 腹腔鏡下DSTにおけるトラブル対処法

    大沼 忍, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　WS32-8　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  253. 胃GISTに対する至適腹腔鏡手術術式 典型的胃部分切除からCLEAN-NETまで

    青木 豪, 井本 博文, 唐澤 秀明, 神山 篤史, 石田 晶玄, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 森川 孝則, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS22-5　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  254. 減量手術のノウハウを活かした肥満合併胃癌に対する腹腔鏡手術

    田中 直樹, 武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 大沼 忍, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS26-8　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  255. 腹腔鏡下大腸全摘回腸嚢肛門吻合術の治療成績

    神山 篤史, 渡辺 和宏, 唐澤 秀明, 田中 直樹, 青木 豪, 井本 博文, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS56-2　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  256. 術前治療後・回腸人工肛門造設下でのCo-axial settingによる腹腔鏡下直腸低位前方切除術

    唐澤 秀明, 大沼 忍, 神山 篤史, 渡辺 和宏, 井本 博文, 青木 豪, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　23　(7)　OS76-8　2018/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  257. 在宅中心静脈栄養症例におけるポートカテーテル 血流感染症に対する抗菌剤/抗真菌剤併用ロック療法の有用性の検討

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 山村 明寛, 井本 博文, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    移植　53　(2-3)　226-226　2018/11

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  258. 腸回転異常症に合併した膵体部癌の1例

    石田晶玄, 大塚英郎, 三浦孝之, 高館達之, 有明恭平, 川口桂, 益田邦洋, 水間正道, 林洋毅, 中川圭, 森川孝則, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    日本臨床外科学会雑誌　79　(増刊)　637-637　2018/10/20

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.79.637 　

    ISSN： 1345-2843

  259. 大腸癌肝転移術後早期再発予測因子の検討

    伊関雅裕, 中川圭, 三浦孝之, 高舘達之, 有明恭平, 川口桂, 石田晶玄, 大塚英郎, 水間正道, 森川孝則, 林洋毅, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    日本臨床外科学会雑誌　79　(増刊)　474-474　2018/10/20

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  260. 当科における家族歴を有する膵癌症例の患者背景,腫瘍学的特徴についての検討

    畠達夫, 水間正道, 元井冬彦, 三浦孝之, 高舘達之, 有明恭平, 川口桂, 石田晶玄, 大塚英郎, 中川圭, 森川孝則, 林洋毅, 亀井尚, 内藤剛, 海野倫明

    日本臨床外科学会雑誌　79　(増刊)　508-508　2018/10/20

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  261. 長時間腎動脈遮断を要した腹部大動脈瘤手術症例における冷却リンゲル液自然滴下灌流による腎保護効果の検討

    堀井晋一良, 菅原宏文, 梅津道久, 海野倫明, 亀井尚

    日本臨床外科学会雑誌　79　401　2018/10/20

    ISSN： 1345-2843

  262. 膵癌に対する膵全摘の適応

    元井 冬彦, 三浦 孝之, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　O17-2　2018/10

    Publisher: (一社)日本癌治療学会

  263. Borderline resectable膵癌の治療戦略と成績 BR/UR-LA膵癌に対する外科治療戦略 Neoadjuvantか? Conversionか?

    元井 冬彦, 伊関 雅裕, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　355-355　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  264. 膵切除後の残膵切除の適応・治療成績 残膵全摘術の短期・長期治療成績

    水間 正道, 元井 冬彦, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　393-393　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  265. 肝切除において腹腔ドレーンは必要か? 肝切除後腹腔ドレーン留置は本当に慎むべきか?

    森川 孝則, 石田 晶玄, 高館 達之, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 宮城 重人, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科感染症学会雑誌　15　(5)　529-529　2018/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  266. 慢性膵炎術後に重症感染性合併症をきたした1例

    水間 正道, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　15　(5)　575-575　2018/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  267. 膵切除後の残膵切除の適応・治療成績 残膵全摘術の短期・長期治療成績

    水間 正道, 元井 冬彦, 三浦 孝之, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　393-393　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  268. 腸回転異常症に合併した膵体部癌の1例

    石田 晶玄, 大塚 英郎, 三浦 孝之, 高館 達之, 有明 恭平, 川口 桂, 益田 邦洋, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　637-637　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  269. 胆道癌・膵癌に対する化学療法の進歩 胆管癌に対する集学的治療戦略

    中川 圭, 益田 邦洋, 海野 倫明

    日本消化器病学会雑誌　115　(臨増大会)　A526-A526　2018/10

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  270. 膵癌に対する膵全摘の適応

    元井 冬彦, 三浦 孝之, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　O17-2　2018/10

    Publisher: (一社)日本癌治療学会

  271. 食道胃接合部癌の術式と治療成績 食道胃接合部癌の縦隔リンパ節至適郭清範囲に関する検討

    櫻井 直, 谷山 裕亮, 日景 允, 佐藤 千晃, 高屋 快, 岡本 宏史, 小野寺 優, 今野 卓朗, 氏家 直人, 安藤 涼平, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　79　(増刊)　290-290　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  272. 胸部食道癌に対するロボット支援食道切除術

    日景 允, 谷山 裕亮, 櫻井 直, 佐藤 千晃, 高屋 快, 岡本 宏史, 小野寺 優, 小関 健, 今野 卓朗, 氏家 直人, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　79　(増刊)　496-496　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  273. 脳動脈瘤を有する褐色細胞腫の患者への対応

    熊田 博之, 西村 隆一, 中西 渉, 中西 史, 宮城 重人, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　79　(増刊)　680-680　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  274. 上腸間膜動脈起始部良性狭窄に対して術前にステントを留置し膵頭十二指腸切除術を施行した膵頭部癌の1例

    篠崎 康晴, 水間 正道, 赤松 大二朗, 益田 邦洋, 石田 昌玄, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 後藤 均, 内藤 剛, 石田 孝宜, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　800-800　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  275. 周術期管理から退院後のTOTAL SUPPORT〜GUT STARVATIONとKAMPO〜 幽門側胃切除術後クリニカルパスへの六君子湯の導入の効果

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 石田 孝宣, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　877-877　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  276. 腹腔鏡下幽門側胃切除における予後規定因子の検討

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　O59-1　2018/10

    Publisher: (一社)日本癌治療学会

  277. 肥満に対する外科治療の最前線 糖尿病に対する手術の現状と展望

    田中 直樹, 井本 博文, 青木 豪, 山村 明寛, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本臨床外科学会雑誌　79　(増刊)　374-374　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  278. クローン病における直腸肛門管癌の癌スクリーニングについての検討 とくに術前CEA値の有用性についての考察

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 山村 明寛, 井本 博文, 唐澤 秀明, 青木 豪, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　79　(増刊)　471-471　2018/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  279. 直腸癌に対する集学的治療における腹腔鏡下人工肛門造設術の有用性

    唐澤 秀明, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　O32-5　2018/10

    Publisher: (一社)日本癌治療学会

  280. 大腸SM癌治療後の再発例の検討

    大沼 忍, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　56回　O34-5　2018/10

    Publisher: (一社)日本癌治療学会

  281. 【あたらしい外科局所解剖全図-ランドマークとその出し方】肝胆膵 Special Lecture 尾状葉門脈枝のバリエーション

    益田 邦洋, 中川 圭, 青木 修一, 海野 倫明

    臨床外科　73　(11)　212-218　2018/10

    Publisher: (株)医学書院

    ISSN： 0386-9857

    eISSN： 1882-1278

  282. カテコールアミン産生神経節細胞芽腫と脳動脈瘤を呈する成人患者に対する手術戦略 1症例報告(Surgical strategy for an adult patient with a catecholamine-producing ganglioneuroblastoma and a cerebral aneurysm: a case report)

    Kumata Hiroyuki, Nishimura Ryuichi, Nakanishi Chikashi, Inoue Chihiro, Tezuka Yuta, Endo Hidenori, Miyagi Shigehito, Tominaga Teiji, Unno Michiaki, Kamei Takashi

    Surgical Case Reports　4　(September)　1-6　2018/09

    Publisher: Springer Berlin Heidelberg

  283. 破裂性腹部大動脈瘤に対する開腹手術とステントグラフト内挿術の検討

    土田 憲, 後藤 均, 赤松 大二朗, 菅原 宏文, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 亀井 尚, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　98-98　2018/09

    Publisher: 日本Acute Care Surgery学会

  284. 血管外科手術の巧み

    後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 亀井 尚, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　42-42　2018/09

    Publisher: 日本Acute Care Surgery学会

  285. 腎動脈上遮断を要する腹部大動脈瘤手術症例に対する冷却リンゲル液自然滴下灌流による腎保護効果の検討

    堀井 晋一良, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 海野 倫明, 亀井 尚

    脈管学　58　(Suppl.)　S174-S174　2018/09

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

  286. 【エビデンスからみた治療リスクの評価】膵癌治療におけるリスクと対応 膵癌治療におけるリスク評価と治療法選択

    水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 林 洋毅, 元井 冬彦, 海野 倫明

    外科　80　(10)　1031-1034　2018/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

    eISSN： 2432-9428

  287. 腎動脈上遮断を要する腹部大動脈瘤手術症例に対する冷却リンゲル液自然滴下灌流による腎保護効果の検討

    堀井 晋一良, 後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 海野 倫明, 亀井 尚

    脈管学　58　(Suppl.)　S174-S174　2018/09

    Publisher: (一社)日本脈管学会

    ISSN： 0387-1126

  288. 血管外科手術の巧み

    後藤 均, 赤松 大二朗, 菅原 宏文, 土田 憲, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 亀井 尚, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　42-42　2018/09

    Publisher: 日本Acute Care Surgery学会

  289. 破裂性腹部大動脈瘤に対する開腹手術とステントグラフト内挿術の検討

    土田 憲, 後藤 均, 赤松 大二朗, 菅原 宏文, 吉田 良太朗, 梅津 道久, 鈴木 峻也, 堀井 晋一良, 亀井 尚, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　98-98　2018/09

    Publisher: 日本Acute Care Surgery学会

  290. 救命し得なかった多発小腸潰瘍の1例

    井本 博文, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 青木 豪, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　141-141　2018/09

    Publisher: 日本Acute Care Surgery学会

    eISSN： 2436-102X

  291. IBD治療における内科・外科・肛門科の連携 クローン病の直腸肛門部癌症例の特徴についての検討 とくに術前CEA値と集学的治療についての考察

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A37-A37　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  292. 遺伝性大腸癌の診断と治療 長期成績からみた家族性大腸腺腫症の外科的治療

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A74-A74　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  293. マップ作成によるクローン病狭窄病変好発部位の新知見

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A95-A95　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  294. 一時的回腸人工肛門に伴うストーマ関連腸閉塞の術式別発生状況

    唐澤 秀明, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A136-A136　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  295. 初回内視鏡治療を施行した大腸SM癌の臨床病理学的検討

    大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A142-A142　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  296. 【切除可能膵癌の術前・術中・術後】 切除可能膵癌に対する術前治療 術前治療の是非、どのようなメリット・デメリットがあるか

    元井 冬彦, 海野 倫明

    日本医事新報　(4926)　28-35　2018/09

    Publisher: (株)日本医事新報社

    ISSN： 0385-9215

  297. 【エビデンスからみた治療リスクの評価】 膵癌治療におけるリスクと対応 膵癌治療におけるリスク評価と治療法選択

    水間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 林 洋毅, 元井 冬彦, 海野 倫明

    外科　80　(10)　1031-1034　2018/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

  298. 膵頭十二指腸切除の要点 動脈先行処理と安全確実な膵消化管吻合

    元井 冬彦, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　45-45　2018/09

    Publisher: 日本Acute Care Surgery学会

  299. 巨大後腹膜腫瘍切除後に椎骨動脈瘤破裂による気道閉塞から心肺停止をきたした神経線維腫症の1例

    三浦 孝之, 伊関 雅裕, 畠 達夫, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　84-84　2018/09

    Publisher: 日本Acute Care Surgery学会

  300. 救命し得なかった多発小腸潰瘍の1例

    井本 博文, 鈴木 秀幸, 山村 明寛, 唐澤 秀明, 青木 豪, 神山 篤史, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    Japanese Journal of Acute Care Surgery　8　(1)　141-141　2018/09

    Publisher: 日本Acute Care Surgery学会

  301. 一時的回腸人工肛門に伴うストーマ関連腸閉塞の術式別発生状況

    唐澤 秀明, 大沼 忍, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(抄録号)　A136-A136　2018/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  302. 胆嚢癌のリスクファクターは何か? 胆嚢癌における術前予後危険因子抽出の必要性

    中川 圭, 益田 邦洋, 海野 倫明

    胆道　32　(3)　437-437　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  303. 術後狭窄 膵頭十二指腸切除後、胆管空腸吻合部狭窄のリスク因子と対策

    伊関 雅裕, 大塚 英郎, 畠 達夫, 益田 邦洋, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 滝川 哲也, 菅野 敦, 正宗 淳, 海野 倫明

    胆道　32　(3)　497-497　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  304. 肝門部領域胆管癌における両葉ドレナージが門脈塞栓術後肝肥大に及ぼす影響

    益田 邦洋, 中川 圭, 深瀬 耕二, 伊関 雅裕, 高館 達之, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    胆道　32　(3)　611-611　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  305. 肝外発生胆管内乳頭状腫瘍(IPNB)の臨床病理学的特徴

    水間 正道, 青木 泰孝, 青木 豪, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    胆道　32　(3)　620-620　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  306. 胆嚢原発hepatoid adenocarcinomaの1例

    佐野 貴紀, 菅野 敦, 鍋島 立秀, 滝川 哲也, 三浦 晋, 森川 孝則, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 淳

    胆道　32　(3)　646-646　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  307. 胆嚢原発hepatoid adenocarcinomaの1例

    佐野 貴紀, 菅野 敦, 鍋島 立秀, 滝川 哲也, 三浦 晋, 森川 孝則, 海野 倫明, 藤島 史喜, 古川 徹, 正宗 淳

    胆道　32　(3)　646-646　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  308. 【胆管内乳頭状腫瘍(IPNB)の病態と診療の現状】 胆管内乳頭状腫瘍(IPNB) 粘液産生の有無で区別する臨床的意義

    水間 正道, 青木 泰孝, 森川 孝則, 元井 冬彦, 古川 徹, 海野 倫明

    胆と膵　39　(8)　707-710　2018/08

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  309. 術後狭窄 膵頭十二指腸切除後、胆管空腸吻合部狭窄のリスク因子と対策

    伊関 雅裕, 大塚 英郎, 畠 達夫, 益田 邦洋, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 滝川 哲也, 菅野 敦, 正宗 淳, 海野 倫明

    胆道　32　(3)　497-497　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  310. 肝門部領域胆管癌における両葉ドレナージが門脈塞栓術後肝肥大に及ぼす影響

    益田 邦洋, 中川 圭, 深瀬 耕二, 伊関 雅裕, 高館 達之, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 海野 倫明

    胆道　32　(3)　611-611　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  311. 肝外発生胆管内乳頭状腫瘍(IPNB)の臨床病理学的特徴

    水間 正道, 青木 泰孝, 青木 豪, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    胆道　32　(3)　620-620　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  312. 同時性・異時性多発病変を呈した胆管癌の1例

    吉町 信吾, 大塚 英郎, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 藤島 史喜, 内藤 剛, 海野 倫明

    胆道　32　(3)　638-638　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  313. 胆管非拡張型の膵・胆管合流異常に合併した若年発症肝門部領域胆管癌の1例

    高橋 裕季, 大塚 英郎, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    胆道　32　(3)　652-652　2018/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  314. 複雑な合流形態を呈し、繰り返す膵炎で発症した膵・胆管合流異常の1例

    山名 浩樹, 大塚 英郎, 石田 晶玄, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　41　83-83　2018/08

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  315. 【徹底解説! 膵尾側切除を極める】術式のポイント 腹腔動脈合併膵体尾部切除術(DP-CAR)の適応と手術手技

    元井 冬彦, 林 洋毅, 海野 倫明

    臨床外科　73　(8)　970-975　2018/08

    Publisher: (株)医学書院

    ISSN： 0386-9857

  316. 75歳以上の高齢胸部食道癌患者に対する縦郭リンパ節郭清

    氏家 直人, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 丸山 祥太, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　73回　932-932　2018/07

    Publisher: (一社)日本消化器外科学会

  317. 肝切除術後必要エネルギー量についての間接熱量計を用いた検討

    中西 渉, 宮城 重人, 中西 史, 原 康之, 西村 隆一, 清水 健司, 植松 智海, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　73回　40-40　2018/07

    Publisher: (一社)日本消化器外科学会

  318. 当科での40歳以下肝切除症例の検討

    宮崎 勇希, 原 康之, 清水 健司, 西村 隆一, 中西 渉, 中西 史, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　73回　311-311　2018/07

    Publisher: (一社)日本消化器外科学会

  319. 肝門部領域胆管癌動脈合併切除症例における動脈再建の工夫 Jump Graftを含めた安全な再建法

    宮城 重人, 中西 史, 原 康之, 中西 渉, 西村 隆一, 清水 健司, 深瀬 耕二, 元井 冬彦, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　653-653　2018/07

    Publisher: (一社)日本消化器外科学会

  320. 後腹膜巨大腫瘍手術症例の検討

    植松 智海, 原 康之, 清水 健司, 西村 隆一, 中西 渉, 中西 史, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　73回　747-747　2018/07

    Publisher: (一社)日本消化器外科学会

  321. 小児肝移植後におけるドナー特異的抗HLA-Cw/DP抗体の意義

    戸子台 和哲, 宮城 重人, 中西 史, 原 康之, 中西 渉, 西村 隆一, 清水 健司, 後藤 昌史, 海野 倫明, 亀井 尚

    日本消化器外科学会総会　73回　953-953　2018/07

    Publisher: (一社)日本消化器外科学会

  322. The Optimization of the Hepatocyte Surface Modification Procedures in Terms of Heparin and Apyrase for Improving Hepatocyte Engraftment

    Hiroyuki Ogasawara, Yuji Teramura, Takehiro Imura, Akiko Inagaki, Yoshikatsu Saito, Muneyuki Matsumura, Kengo Fukuoka, Ibrahim Fathi, Shigehito Miyagi, Kristina Nilsson, Kazuo Ohashi, Michiaki Unno, Takashi Kamei, Susumu Satomi, Bo Nilsson, Elisabet Gustafson, Masafumi Goto

    TRANSPLANTATION　102　S727-S727　2018/07

    DOI： 10.1097/01.tp.0000543706.60801.e9 　

    ISSN： 0041-1337

    eISSN： 1534-6080

  323. Analysis of the Association of Posttransplant Donor-Specific HLA Antibody with Liver Fibrosis After Pediatric Liver Transplantation

    Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Ryuichi Nishimura, Koji Miyazawa, Satomi Uematsu, Kenji Shimizu, Keigo Murakami, Hironobu Sasano, Masafumi Goto, Michiaki Unno, Takashi Kamei

    TRANSPLANTATION　102　S127-S127　2018/07

    DOI： 10.1097/01.tp.0000542741.72759.61 　

    ISSN： 0041-1337

    eISSN： 1534-6080

  324. 当科における膵尾部切除術を付加したFrey手術の検討

    佐藤 英昭, 石田 晶玄, 青木 豪, 山村 明寛, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会総会　73回　356-356　2018/07

    Publisher: (一社)日本消化器外科学会

  325. 【胆膵】切除不能膵癌に対するConversion surgery 切除不能膵癌に対するConversion Surgeryの適応 無再発生存を指標として

    元井 冬彦, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 江川 新一, 海野 倫明

    日本消化器外科学会総会　73回　860-860　2018/07

    Publisher: (一社)日本消化器外科学会

  326. 逆流防止弁形成食道残胃吻合再建を用いた腹腔鏡補助下噴門側胃切除術の長期成績

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　455-455　2018/07

    Publisher: (一社)日本消化器外科学会

  327. 胃GISTに対する治療戦略 低侵襲手術から術前治療まで

    青木 豪, 唐澤 秀明, 井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　812-812　2018/07

    Publisher: (一社)日本消化器外科学会

  328. 当院における胃GISTに対する腹腔鏡・内視鏡合同手術(LECS)

    井本 博文, 唐澤 秀明, 青木 豪, 田中 直樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　934-934　2018/07

    Publisher: (一社)日本消化器外科学会

  329. 大腸癌合併潰瘍性大腸炎36例の検討

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　284-284　2018/07

    Publisher: (一社)日本消化器外科学会

  330. 腹腔鏡下大腸切除術における術中偶発症の検討とその対応

    大沼 忍, 内藤 剛, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　303-303　2018/07

    Publisher: (一社)日本消化器外科学会

  331. 他臓器浸潤直腸癌に対する術前化学放射線療法の有用性

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 神山 篤史, 鈴木 秀幸, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　404-404　2018/07

    Publisher: (一社)日本消化器外科学会

  332. 潰瘍性大腸炎手術例における炎症の深さと手術のタイミング

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 武者 宏明, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　714-714　2018/07

    Publisher: (一社)日本消化器外科学会

  333. 翻転困難腸管に対する高浸透圧を利用したストーマ造設手技及び萎縮腸管に対する新吻合法によるストーマ閉鎖

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　862-862　2018/07

    Publisher: (一社)日本消化器外科学会

  334. Stage II大腸癌の治療成績および危険因子、術後補助化学療法の検討

    平嶋 倫亮, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　1050-1050　2018/07

    Publisher: (一社)日本消化器外科学会

  335. クローン病における直腸肛門管癌の癌スクリーニングの現状と問題点 国内専門施設へのアンケート調査

    渡辺 和宏, 倉地 清隆, 水島 恒和, 亀山 仁史, 佐々木 巌, 杉田 昭, 根津 理一郎, 舟山 裕士, 福島 浩平, 内藤 剛, 海野 倫明, 二見 喜太郎

    日本大腸肛門病学会雑誌　71　(7)　283-290　2018/07

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  336. GIST肝転移手術症例の検討

    吉町 信吾, 大塚 英郎, 有明 恭平, 益田 邦洋, 深瀬 耕二, 中川 圭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　39-39　2018/07

    Publisher: (一社)日本消化器外科学会

  337. 【胆膵】胆管癌に対する術前治療の意義 胆管癌に対する術前化学放射線療法の有用性とその適応

    中川 圭, 深瀬 耕二, 益田 邦洋, 伊関 雅裕, 高舘 達之, 大塚 英郎, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　68-68　2018/07

    Publisher: (一社)日本消化器外科学会

  338. 【肝】肝内胆管癌の予後改善に向けた取り組み 腫瘤形成型肝内胆管癌に対するリンパ節郭清を伴う胆管切除の意義

    益田 邦洋, 中川 圭, 伊関 雅裕, 高舘 達之, 深瀬 耕二, 大塚 英郎, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　267-267　2018/07

    Publisher: (一社)日本消化器外科学会

  339. 当科における膵尾部切除術を付加したFrey手術の検討

    佐藤 英昭, 石田 晶玄, 青木 豪, 山村 明寛, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会総会　73回　356-356　2018/07

    Publisher: (一社)日本消化器外科学会

  340. 肝門部領域胆管癌動脈合併切除症例における動脈再建の工夫 Jump Graftを含めた安全な再建法

    宮城 重人, 中西 史, 原 康之, 中西 渉, 西村 隆一, 清水 健司, 深瀬 耕二, 元井 冬彦, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　653-653　2018/07

    Publisher: (一社)日本消化器外科学会

  341. 血管合併切除を伴う肝門部領域胆管癌手術

    深瀬 耕二, 益田 邦洋, 中川 圭, 林 洋毅, 森川 孝則, 宮城 重人, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　653-653　2018/07

    Publisher: (一社)日本消化器外科学会

  342. 噴門側胃切後の十二指腸乳頭部癌に対して右胃動脈温存膵頭十二指腸切除術を施行し術中血流評価を行った1例

    高橋 裕季, 益田 邦洋, 有明 恭平, 深瀬 耕二, 大塚 英郎, 中川 圭, 内藤 剛, 元井 冬彦, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　690-690　2018/07

    Publisher: (一社)日本消化器外科学会

  343. 潰瘍性大腸炎手術例における炎症の深さと手術のタイミング

    鈴木 秀幸, 渡辺 和宏, 神山 篤史, 大沼 忍, 唐澤 秀明, 武者 宏明, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　714-714　2018/07

    Publisher: (一社)日本消化器外科学会

  344. 胆管癌におけるFBXW7発現の意義と基質MCL1を介した分子メカニズム

    盛 彬子, 益田 邦洋, 有明 恭平, 深瀬 耕二, 大塚 英郎, 中川 圭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　741-741　2018/07

    Publisher: (一社)日本消化器外科学会

  345. 膵癌術前治療後の低骨格筋量は予後不良因子である

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　745-745　2018/07

    Publisher: (一社)日本消化器外科学会

  346. 膵癌術前治療前後のPET SUVmax値の変化と組織学的治療効果の関係

    客本 ゆき恵, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　745-745　2018/07

    Publisher: (一社)日本消化器外科学会

  347. 膵管内乳頭粘液性腺癌(IPMC)の予測診断における血液中の炎症性マーカー測定の有用性

    畠 達夫, 水間 正道, 元井 冬彦, 森川 孝則, 高舘 達之, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　836-836　2018/07

    Publisher: (一社)日本消化器外科学会

  348. 膵頭十二指腸切除術周術期における血中アルブミン値と、アルブミン投与の意義

    大塚 英郎, 石田 晶玄, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　845-845　2018/07

    Publisher: (一社)日本消化器外科学会

  349. 腹膜播種の診断と治療の工夫 膵癌に対する審査腹腔鏡の有効性

    高舘 達之, 森川 孝則, 石田 晶玄, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　855-855　2018/07

    Publisher: (一社)日本消化器外科学会

  350. 【胆膵】切除不能膵癌に対するConversion surgery 切除不能膵癌に対するConversion Surgeryの適応 無再発生存を指標として

    元井 冬彦, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 亀井 尚, 江川 新一, 海野 倫明

    日本消化器外科学会総会　73回　860-860　2018/07

    Publisher: (一社)日本消化器外科学会

  351. 膵全摘後長期生存例の栄養状態の検討

    初沢 悠人, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　960-960　2018/07

    Publisher: (一社)日本消化器外科学会

  352. 切除可能膵癌における術前Gemcitabine+S-1併用療法の治療成績

    水間 正道, 元井 冬彦, 深瀬 耕二, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　1027-1027　2018/07

    Publisher: (一社)日本消化器外科学会

  353. Stage II大腸癌の治療成績および危険因子、術後補助化学療法の検討

    平嶋 倫亮, 大沼 忍, 鈴木 秀幸, 唐澤 秀明, 神山 篤史, 渡辺 和宏, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　1050-1050　2018/07

    Publisher: (一社)日本消化器外科学会

  354. Barrett食道癌における腫瘍浸潤リンパ球及び腫瘍関連好中球の予後因子としての有用性

    郷右近 祐介, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 藤島 史喜, 内藤 剛, 亀井 尚, 海野 倫明, 笹野 公伸

    日本消化器外科学会総会　73回　663-663　2018/07

    Publisher: (一社)日本消化器外科学会

  355. 【最新版 "腸閉塞"を極める!】疾患別 診断と治療 慢性偽性腸閉塞症

    渡辺 和宏, 内藤 剛, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 大沼 忍, 武者 宏昭, 亀井 尚, 海野 倫明

    臨床外科　73　(7)　830-834　2018/07

    Publisher: (株)医学書院

    ISSN： 0386-9857

  356. 大腸癌合併潰瘍性大腸炎36例の検討

    神山 篤史, 渡辺 和宏, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　284-284　2018/07

    Publisher: (一社)日本消化器外科学会

  357. 腹腔鏡下大腸切除術における術中偶発症の検討とその対応

    大沼 忍, 内藤 剛, 唐澤 秀明, 鈴木 秀幸, 神山 篤史, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　303-303　2018/07

    Publisher: (一社)日本消化器外科学会

  358. 他臓器浸潤直腸癌に対する術前化学放射線療法の有用性

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 神山 篤史, 鈴木 秀幸, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　404-404　2018/07

    Publisher: (一社)日本消化器外科学会

  359. 逆流防止弁形成食道残胃吻合再建を用いた腹腔鏡補助下噴門側胃切除術の長期成績

    武者 宏昭, 井本 博文, 山村 明寛, 青木 豪, 田中 直樹, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　455-455　2018/07

    Publisher: (一社)日本消化器外科学会

  360. 胃GISTに対する治療戦略 低侵襲手術から術前治療まで

    青木 豪, 唐澤 秀明, 井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　812-812　2018/07

    Publisher: (一社)日本消化器外科学会

  361. 翻転困難腸管に対する高浸透圧を利用したストーマ造設手技及び萎縮腸管に対する新吻合法によるストーマ閉鎖

    渡辺 和宏, 神山 篤史, 鈴木 秀幸, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　73回　862-862　2018/07

    Publisher: (一社)日本消化器外科学会

  362. 当院における胃GISTに対する腹腔鏡・内視鏡合同手術(LECS)

    井本 博文, 唐澤 秀明, 青木 豪, 田中 直樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本消化器外科学会総会　73回　934-934　2018/07

    Publisher: (一社)日本消化器外科学会

  363. 急速な増悪を伴った、切迫破裂により診断された肝未分化型肉腫の成人症例(A case of an adult undifferentiated sarcoma of liver that diagnosed by imminent rupture, with rapid poor progress)

    Suzuki Uematsu Satomi, Nakanishi Chikashi, Kakizaki Yuta, Matsumura Muneyuki, Shimizu Kenji, Nakanishi Wataru, Nishimura Ryuichi, Hara Yasuyuki, Miyagi Shigehito, Naito Takeshi, Unno Michiaki, Kamei Takashi

    日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　364-364　2018/06

    Publisher: (一社)日本肝胆膵外科学会

  364. 肝移植で術中大量出血がみられた後の周術期管理と長期予後(Perioperative management and long-term prognosis after intraoperative massive bleeding in liver transplantation)

    Nakanishi Wataru, Miyagi Shigehito, Nakanishi Chikashi, Hara Yasuyuki, Nishimura Ryuichi, Shimizu Kenji, Uematsu Satomi, Kakizaki Yuta, Matsumura Muneyuki, Kamei Takashi, Unno Michiaki

    日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　441-441　2018/06

    Publisher: (一社)日本肝胆膵外科学会

  365. 生体肝移植における顕微鏡下outer knotted sutureによる胆道再建術の初期結果と胆道狭窄の危険因子(Early term results of biliary reconstruction using microsurgical outer knotted suture technique and risk factors of biliary stricture in living donor liver transplantation)

    Miyagi Shigehito, Nakanishi Chikashi, Hara Yasuyuki, Nakanishi Wataru, Nishimura Ryuichi, Motoi Fuyuhiko, Kamei Takashi, Unno Michiaki

    日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　447-447　2018/06

    Publisher: (一社)日本肝胆膵外科学会

  366. 肝管空腸吻合を伴う生体肝移植後の胆道狭窄 危険因子、治療、長期追跡調査(Biliary stricture after living-donor liver transplantation with hepaticojejunostomy: risk factors, treatment and long-term follow up)

    Nakanishi Chikashi, Miyagi Shigehito, Tokodai Kazuaki, Hara Yasuyuki, Nakanishi Wataru, Nishimura Ryuichi, Kamei Takashi, Unno Michiaki

    日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　447-447　2018/06

    Publisher: (一社)日本肝胆膵外科学会

  367. 本邦におけるスリーブ状胃切除術およびスリーブ・バイパス術の糖尿病改善効果の検討 多施設共同研究結果より

    井本 博文, 笠間 和典, 関 洋介, 太田 正之, 大城 崇司, 佐々木 章, 林 秀樹, 宮崎 安弘, 山口 剛, 田中 直樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36回　117-117　2018/06

    Publisher: 日本肥満症治療学会

  368. 十二指腸空腸バイパス手術における胆膵路の長さの違いが代謝に及ぼす影響とその機序の検討

    伊勢 一郎, 田中 直樹, 上野 知尭, 小野 智之, 井本 博文, 神山 篤史, 渡辺 和宏, 前川 正充, 亀井 尚, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36回　107-107　2018/06

    Publisher: 日本肥満症治療学会

  369. 個別化、統合化した肥満症精密治療(Precision and integrated obesity medicine)に向けて 肥満2型糖尿病の治療を考える 内科治療と肥満外科治療 2型糖尿病に対する代謝改善手術の有効性と病態改善機序

    内藤 剛, 田中 直樹, 井本 博文, 元井 冬彦, 亀井 尚, 石田 孝宣, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36回　50-50　2018/06

    Publisher: 日本肥満症治療学会

  370. 本邦におけるスリーブ状胃切除術およびスリーブ・バイパス術の糖尿病改善効果の検討 多施設共同研究結果より

    井本 博文, 笠間 和典, 関 洋介, 太田 正之, 大城 崇司, 佐々木 章, 林 秀樹, 宮崎 安弘, 山口 剛, 田中 直樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36回　117-117　2018/06

    Publisher: 日本肥満症治療学会

  371. 十二指腸空腸バイパス手術における胆膵路の長さの違いが代謝に及ぼす影響とその機序の検討

    伊勢一郎, 田中直樹, 上野知尭, 小野智之, 井本博文, 神山篤史, 渡辺和宏, 前川正充, 亀井尚, 内藤剛, 海野倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36th　107-107　2018/06

    Publisher: 日本肥満症治療学会

  372. 重症NASHを合併した高度肥満患者に対してスリーブ状胃切除術を施行した一例

    上野知尭, 井本博文, 田中直樹, 武者宏昭, 青木豪, 山村明寛, 大沼忍, 渡辺和宏, 神山篤史, 唐澤秀明, 鈴木秀幸, 元井冬彦, 亀井尚, 海野倫明, 内藤剛

    日本肥満症治療学会学術集会プログラム・抄録集　36th　146-146　2018/06

    Publisher: 日本肥満症治療学会

  373. 当院の減量・代謝改善手術の治療成績と治療効果予測因子

    田中直樹, 井本博文, 伊勢一郎, 上野知堯, 青木豪, 山村明寛, 渡辺和宏, 神山篤史, 大沼忍, 武者宏昭, 元井冬彦, 亀井尚, 海野倫明, 内藤剛

    日本肥満症治療学会学術集会プログラム・抄録集　36th　108-108　2018/06

    Publisher: 日本肥満症治療学会

  374. 個別化、統合化した肥満症精密治療(Precision and integrated obesity medicine)に向けて 肥満2型糖尿病の治療を考える 内科治療と肥満外科治療 2型糖尿病に対する代謝改善手術の有効性と病態改善機序

    内藤 剛, 田中 直樹, 井本 博文, 元井 冬彦, 亀井 尚, 石田 孝宣, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　36回　50-50　2018/06

    Publisher: 日本肥満症治療学会

  375. 当院の減量・代謝改善手術の治療成績と治療効果予測因子

    田中 直樹, 井本 博文, 伊勢 一郎, 上野 知尭, 青木 豪, 山村 明寛, 渡辺 和宏, 神山 篤史, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本肥満症治療学会学術集会プログラム・抄録集　36回　108-108　2018/06

    Publisher: 日本肥満症治療学会

  376. 重症NASHを合併した高度肥満患者に対してスリーブ状胃切除術を施行した一例

    上野 知尭, 井本 博文, 田中 直樹, 武者 宏昭, 青木 豪, 山村 明寛, 大沼 忍, 渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 元井 冬彦, 亀井 尚, 海野 倫明, 内藤 剛

    日本肥満症治療学会学術集会プログラム・抄録集　36回　146-146　2018/06

    Publisher: 日本肥満症治療学会

  377. 動脈接触膵頭部癌に対する集学的治療戦略

    元井 冬彦, 畠 達夫, 有明 恭平, 青木 豪, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　426-426　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  378. 初診時局所進行切除不能膵癌に対する治療戦略

    林 洋毅, 有明 恭平, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 江川 新一, 亀井 尚, 海野 倫明

    膵臓　33　(3)　457-457　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  379. 腹腔鏡下脾温存膵体尾部切除術の術後成績 脾合併切除術との比較から

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　529-529　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  380. 膵管内乳頭粘液性腺癌の予測診断における血清抗p53抗体測定の意義

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 古川 徹, 江川 新一, 海野 倫明

    膵臓　33　(3)　552-552　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  381. 膵粘液性嚢胞腫瘍(MCN)の治療戦略の検討

    高舘 達之, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　553-553　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  382. 膵癌における術前治療と効果判定-画像・病理診断と腫瘍マーカーを中心に- 膵癌術前治療における組織効果と画像・腫瘍マーカーの変化との関係

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 有明 恭平, 高舘 達之, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    膵臓　33　(3)　355-355　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  383. 当院における非機能性pNENの予後についての検討

    滝川 哲也, 菅野 敦, 本郷 星仁, 鍋島 立秀, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 元井 冬彦, 海野 倫明, 藤島 史喜, 下瀬川 徹, 正宗 淳

    膵臓　33　(3)　527-527　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  384. 化合物ライブラリーを用いた抗癌剤耐性ABCトランスポーター抑制剤の同定

    大沼忍, 杉沢徳彦, 石田晶玄, 鈴木秀幸, 井本博文, 山村明寛, 唐澤秀明, 神山篤史, 青木豪, 渡辺和宏, 田中直樹, 武者宏昭, 元井冬彦, 亀井尚, 内藤剛, 海野倫明

    がんと代謝研究会プログラム&amp;抄録集　6th　95　2018/05

  385. 先天性胆道拡張症、膵・胆管合流異常における術後長期合併症の検討

    大塚 英郎, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本小児外科学会雑誌　54　(3)　559-559　2018/05

    Publisher: (NPO)日本小児外科学会

    ISSN： 0288-609X

    eISSN： 2187-4247

  386. 【肝胆膵疾患のエピジェネティクスを学ぶ】 膵疾患のエピジェネティクス 膵IPMNのメチル化解析と診断への応用

    畠 達夫, 水間 正道, 元井 冬彦, 海野 倫明, Goggins Michael

    肝・胆・膵　76　(5)　939-944　2018/05

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  387. 切除不能膵癌における治療方針-conversion surgeryの是非- 切除不能膵癌に対するConversion Surgeryの意義

    元井 冬彦, 海野 倫明, 膵癌術前治療研究会

    膵臓　33　(3)　340-340　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  388. 膵癌における術前治療と効果判定-画像・病理診断と腫瘍マーカーを中心に- 膵癌術前治療における組織効果と画像・腫瘍マーカーの変化との関係

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 有明 恭平, 高舘 達之, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    膵臓　33　(3)　355-355　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  389. プロテオミクス解析により発見した膵神経内分泌腫瘍の新規肝転移関連因子

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 青木 豪, 深瀬 耕二, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    膵臓　33　(3)　370-370　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  390. 動脈接触膵頭部癌に対する集学的治療戦略

    元井 冬彦, 畠 達夫, 有明 恭平, 青木 豪, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　426-426　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  391. 初診時局所進行切除不能膵癌に対する治療戦略

    林 洋毅, 有明 恭平, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 江川 新一, 亀井 尚, 海野 倫明

    膵臓　33　(3)　457-457　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  392. 膵管内乳頭粘液性腫瘍の発生・進展における染色体不安定性の関与

    畠 達夫, 水間 正道, 元井 冬彦, 海野 倫明, Goggins Michael

    膵臓　33　(3)　478-478　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  393. CD-DST法を用いた抗癌剤感受性試験は膵癌術後補助治療の有効性を予測する

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 高舘 達之, 畠 達夫, 内藤 剛, 亀井 尚, 海野 倫明

    膵臓　33　(3)　501-501　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  394. 当院における非機能性pNENの予後についての検討

    滝川 哲也, 菅野 敦, 本郷 星仁, 鍋島 立秀, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 元井 冬彦, 海野 倫明, 藤島 史喜, 下瀬川 徹, 正宗 淳

    膵臓　33　(3)　527-527　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  395. 腹腔鏡下脾温存膵体尾部切除術の術後成績 脾合併切除術との比較から

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　529-529　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  396. 膵管内乳頭粘液性腺癌の予測診断における血清抗p53抗体測定の意義

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 古川 徹, 江川 新一, 海野 倫明

    膵臓　33　(3)　552-552　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  397. 膵粘液性嚢胞腫瘍(MCN)の治療戦略の検討

    高舘 達之, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　33　(3)　553-553　2018/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  398. 先天性胆道拡張症、膵・胆管合流異常における術後長期合併症の検討

    大塚 英郎, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本小児外科学会雑誌　54　(3)　559-559　2018/05

    Publisher: (NPO)日本小児外科学会

    ISSN： 0288-609X

  399. 【膵癌update】 治療 膵癌に対する術前補助療法

    元井 冬彦, 海野 倫明

    臨床消化器内科　33　(7)　831-837　2018/05

    Publisher: (株)日本メディカルセンター

    DOI： 10.19020/CG.0000000399 　

    ISSN： 0911-601X

  400. 【胆道・膵疾患術後の晩期障害】 膵・胆管合流異常、先天性胆道拡張症分流手術後の胆道癌

    大塚 英郎, 水間 正道, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    胆と膵　39　(5)　459-465　2018/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  401. 【胆道・膵疾患術後の晩期障害】 慢性膵炎に対するFrey手術後の再燃・発癌

    江川 新一, 石田 晶玄, 元井 冬彦, 海野 倫明

    胆と膵　39　(5)　491-494　2018/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  402. 心停止下摘出肝グラフトに対する移植前室温酸素化灌流の臓器保存効果

    柿崎 裕太, 宮城 重人, 清水 健司, 熊田 博之, 松村 宗幸, 宮崎 勇希, 福岡 健吾, 植松 智海, 原 康之, 戸子台 和哲, 中西 史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1248-1248　2018/04

    Publisher: (一社)日本外科学会

  403. 胆管癌における予後予測因子としてのFBXW7発現の意義と分子メカニズム

    盛 彬子, 益田 邦洋, 四條 正浩, 有明 恭平, 深瀬 耕二, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 藤島 史喜, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　989-989　2018/04

    Publisher: (一社)日本外科学会

  404. Stomatin like protein 2はEMTを介した膵癌細胞の移動浸潤能を制御する

    有明 恭平, 党 超, 大塚 英郎, 元井 冬彦, 水間 正道, 林 洋毅, 深瀬 耕二, 益田 邦洋, 高舘 達之, 中川 圭, 森川 孝則, 畠 達夫, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2454-2454　2018/04

    Publisher: (一社)日本外科学会

  405. ハイブリッド手術室を用いた新たな外科手術の試み

    原 康之, 宮城 重人, 中西 史, 中西 渉, 宮澤 恒持, 植松 智海, 清水 健司, 赤松 大二朗, 後藤 均, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　2540-2540　2018/04

    Publisher: (一社)日本外科学会

  406. 女性外科医のキャリアパス 女性医師支援の現状把握と今後の展望

    佐藤 章子, 多田 寛, 渡部 剛, 宮下 穣, 原田 成美, 濱中 洋平, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　261-261　2018/04

    Publisher: (一社)日本外科学会

  407. 術前化学療法で乳癌治療は変わるか? 乳癌術前化学療法の現状と今後の課題 自験例からの検討

    宮下 穣, 多田 寛, 渡部 剛, 原田 成美, 濱中 洋平, 佐藤 章子, 海野 倫明, 内藤 剛, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　717-717　2018/04

    Publisher: (一社)日本外科学会

  408. 高感度定量的病理診断法"Nano-IHC"を用いた薬剤耐性バイオマーカーによる乳癌術前化学療法後の癌遺残症例の検討

    多田 寛, 宮下 穣, 佐藤 章子, 濱中 洋平, 原田 成美, 渡部 剛, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　759-759　2018/04

    Publisher: (一社)日本外科学会

  409. メタボロミクスを用いた乳癌組織におけるメチオニン代謝特性の解明とメチオニンPETへの応用の可能性

    原田 成美, 多田 寛, 渡部 剛, 宮下 穰, 濱中 洋平, 佐藤 章子, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　2131-2131　2018/04

    Publisher: (一社)日本外科学会

  410. UR膵癌に対する治療戦略 切除不能膵癌に対するConversion Surgey(CS)の適応 無再発生存期間の目標設定に基づくCS実施基準の再考

    元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 江川 新一, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　619-619　2018/04

    Publisher: (一社)日本外科学会

  411. 膵神経内分泌腫瘍のWHO2017分類におけるNET-G3とNEC-G3の比較検討

    青木 豪, 大塚 英郎, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 江川 新一, 元井 冬彦, 石田 孝宣, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1014-1014　2018/04

    Publisher: (一社)日本外科学会

  412. Runx1エンハンサーは膵臓において幹/プロジェニター細胞をマークする

    佐藤 英昭, 山村 明寛, 松尾 純一, 木村 俊一, 青木 豪, Lim Yi Hui Melissa, 須田 一人, 内藤 剛, 石田 孝宣, 亀井 尚, 大里 元美, 海野 倫明, 伊藤 嘉明

    日本外科学会定期学術集会抄録集　118回　2449-2449　2018/04

    Publisher: (一社)日本外科学会

  413. 多臓器の幹細胞におけるRunx1エンハンサーとLgr5の関与

    山村 明寛, 松尾 純一, 佐藤 英昭, Lim Yi Hui Melissa, Mon Naing Naing, Dede Liana Heng, Hosain Md Zakir, 青木 豪, 内藤 剛, 亀井 尚, Yeoh Khay Guan, 海野 倫明, 大里 元美, 伊藤 嘉明

    日本外科学会定期学術集会抄録集　118回　2467-2467　2018/04

    Publisher: (一社)日本外科学会

  414. 重症糖尿病に対するスリーブバイパス術の効果 日本人を対象とした多施設共同研究結果から Obesity Surgery

    内藤 剛, 笠間 和典, 関 洋介, 太田 正之, 大城 崇司, 佐々木 章, 宮崎 安弘, 山口 剛, 林 秀樹, 井本 博文, 田中 直樹, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　770-770　2018/04

    Publisher: (一社)日本外科学会

  415. クローン病における再(再々)手術率の検討および頻回の再手術例に対する新吻合法の有用性の検討

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　936-936　2018/04

    Publisher: (一社)日本外科学会

  416. pT因子によるStageII大腸癌の細分化は妥当である

    宇根 範和, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 村上 恵, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1132-1132　2018/04

    Publisher: (一社)日本外科学会

  417. 腹腔鏡下幽門側胃切除における予後規定因子の検討

    武者 宏昭, 村上 恵, 井本 博文, 鈴木 秀幸, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1558-1558　2018/04

    Publisher: (一社)日本外科学会

  418. 当院における病的肥満症に対する減量手術の治療成績

    井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 長尾 宗紀, 渡辺 和宏, 工藤 克昌, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1924-1924　2018/04

    Publisher: (一社)日本外科学会

  419. 肥満治療の最前線 新規薬剤開発から外科治療 日本における肥満と糖尿病の外科的治療の現状と将来展望(Forefront research into obesity management: from development of novel agents to surgical therapy Current status and future perspective of surgical treatment for obesity and diabetes in Japan)

    内藤 剛, 井本 博文, 田中 直樹, 元井 冬彦, 亀井 尚, 海野 倫明

    糖尿病　61　(Suppl.1)　S-95　2018/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  420. 原発性大腸癌イレウスに対するBridge to Surgeryとしての大腸ステントの有効性の検討

    神山篤史, 乙供茂, 梶原大輝, 内藤剛, 石田孝宣, 亀井尚, 海野倫明

    日本外科学会定期学術集会(Web)　118th　ROMBUNNO.PS‐004‐2 (WEB ONLY)-1503　2018/04

    Publisher: (一社)日本外科学会

  421. 【イラストで学ぶ解剖学的変異-外科手術アトラス】肝胆膵外科領域 門脈輪状膵

    水間 正道, 林 洋毅, 元井 冬彦, 海野 倫明

    外科　80　(5)　551-554　2018/04

    Publisher: (株)南江堂

    DOI： 10.15106/j_geka80_551 　

    ISSN： 0016-593X

  422. 女性外科医のキャリアパス 女性医師支援の現状把握と今後の展望

    佐藤 章子, 多田 寛, 渡部 剛, 宮下 穣, 原田 成美, 濱中 洋平, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　261-261　2018/04

    Publisher: (一社)日本外科学会

  423. 膵神経内分泌腫瘍におけるプロゲステロン受容体発現とインスリン産生の関連

    橘 知睦, 笠島 敦子, 青木 豪, Samaneh Yazdanikivi, 藤島 史喜, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明, 笹野 公伸

    日本外科学会定期学術集会抄録集　118回　1013-1013　2018/04

    Publisher: (一社)日本外科学会

  424. 膵手術と短期成績(Lateral pancreatico-jejunostomy)

    石田 晶玄, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 大沼 忍, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　382-382　2018/04

    Publisher: (一社)日本外科学会

  425. 術後合併症予防・早期回復のための周術期管理の工夫 当科におけるEnhanced Recovery After Surgeryの原発性肝癌に対する肝切除における効果についての検討

    中西 渉, 宮城 重人, 中西 史, 戸子台 和哲, 原 康之, 宮澤 恒持, 清水 健司, 植松 智海, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　394-394　2018/04

    Publisher: (一社)日本外科学会

  426. IPMNとIPNB-診断と治療のアップデート- 新分類(type1、type2)による胆管内乳頭状腫瘍(IPNB)切除例の検討

    水間 正道, 青木 泰孝, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 古川 徹, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　560-560　2018/04

    Publisher: (一社)日本外科学会

  427. Border line膵癌に対する腹腔動脈合併尾側膵切除術(DP-CAR)の意義 腹腔動脈接触角度と術前治療有無からみた、当科DP-CAR症例の予後の検討

    林 洋毅, 元井 冬彦, 水間 正道, 有明 恭平, 畠 達夫, 高舘 達之, 伊関 雅裕, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　607-607　2018/04

    Publisher: (一社)日本外科学会

  428. UR膵癌に対する治療戦略 切除不能膵癌に対するConversion Surgey(CS)の適応 無再発生存期間の目標設定に基づくCS実施基準の再考

    元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 江川 新一, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　619-619　2018/04

    Publisher: (一社)日本外科学会

  429. 安全に配慮した高難度腹腔鏡下膵切除 Referee systemを用いた安全な腹腔鏡下膵頭十二指腸切除術の導入

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 大沼 忍, 深瀬 耕二, 大塚 英郎, 水間 正道, 武者 宏昭, 中川 圭, 林 洋毅, 宮城 重人, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　686-686　2018/04

    Publisher: (一社)日本外科学会

  430. 進行胆嚢癌に対する集学的治療と新たな治療 進行胆嚢癌の治療成績から見た手術適応と治療戦略

    益田 邦洋, 林 洋毅, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　696-696　2018/04

    Publisher: (一社)日本外科学会

  431. 術前化学療法で乳癌治療は変わるか? 乳癌術前化学療法の現状と今後の課題 自験例からの検討

    宮下 穣, 多田 寛, 渡部 剛, 原田 成美, 濱中 洋平, 佐藤 章子, 海野 倫明, 内藤 剛, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　717-717　2018/04

    Publisher: (一社)日本外科学会

  432. 高感度定量的病理診断法"Nano-IHC"を用いた薬剤耐性バイオマーカーによる乳癌術前化学療法後の癌遺残症例の検討

    多田 寛, 宮下 穣, 佐藤 章子, 濱中 洋平, 原田 成美, 渡部 剛, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　759-759　2018/04

    Publisher: (一社)日本外科学会

  433. 重症糖尿病に対するスリーブバイパス術の効果 日本人を対象とした多施設共同研究結果から Obesity Surgery

    内藤 剛, 笠間 和典, 関 洋介, 太田 正之, 大城 崇司, 佐々木 章, 宮崎 安弘, 山口 剛, 林 秀樹, 井本 博文, 田中 直樹, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　770-770　2018/04

    Publisher: (一社)日本外科学会

  434. クローン病における再(再々)手術率の検討および頻回の再手術例に対する新吻合法の有用性の検討

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　936-936　2018/04

    Publisher: (一社)日本外科学会

  435. 肝切除を伴う胆道癌手術症例における敗血症発症の背景と長期予後

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    日本外科学会定期学術集会抄録集　118回　987-987　2018/04

    Publisher: (一社)日本外科学会

  436. 胆管癌における予後予測因子としてのFBXW7発現の意義と分子メカニズム

    盛 彬子, 益田 邦洋, 四條 正浩, 有明 恭平, 深瀬 耕二, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 藤島 史喜, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　989-989　2018/04

    Publisher: (一社)日本外科学会

  437. 膵神経内分泌腫瘍におけるプロゲステロン受容体発現とインスリン産生の関連

    橘 知睦, 笠島 敦子, 青木 豪, Samaneh Yazdanikivi, 藤島 史喜, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明, 笹野 公伸

    日本外科学会定期学術集会抄録集　118回　1013-1013　2018/04

    Publisher: (一社)日本外科学会

  438. 膵神経内分泌腫瘍のWHO2017分類におけるNET-G3とNEC-G3の比較検討

    青木 豪, 大塚 英郎, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 江川 新一, 元井 冬彦, 石田 孝宣, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1014-1014　2018/04

    Publisher: (一社)日本外科学会

  439. 膵管内乳頭粘液性腺癌の早期診断に有用なバイオマーカーの同定 嚢胞液を用いた探索的研究

    畠 達夫, 水間 正道, 森川 孝則, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明, Hruban Ralph, Goggins Michael

    日本外科学会定期学術集会抄録集　118回　1015-1015　2018/04

    Publisher: (一社)日本外科学会

  440. 小児肝移植後ドナー特異的抗HLA抗体と肝線維化の関連

    戸子台 和哲, 宮城 重人, 中西 史, 原 康之, 中西 渉, 宮澤 恒持, 植松 智海, 清水 健司, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1076-1076　2018/04

    Publisher: (一社)日本外科学会

  441. Barrett食道癌に対するリンパ節郭清範囲と術式の検討

    郷右近 祐介, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 丸山 祥太, 岡本 宏史, 石田 裕嵩, 小野寺 優, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1098-1098　2018/04

    Publisher: (一社)日本外科学会

  442. pT因子によるStageII大腸癌の細分化は妥当である

    宇根 範和, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 村上 恵, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 亀井 尚, 石田 孝宣, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1132-1132　2018/04

    Publisher: (一社)日本外科学会

  443. 肉眼的根治が得られた甲状腺乳頭癌Ex2症例に対する術後放射性ヨード治療

    佐藤 真実, 中島 範昭, 高橋 淑郎, 藤盛 啓成, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　1214-1214　2018/04

    Publisher: (一社)日本外科学会

  444. 心停止下摘出肝グラフトに対する移植前室温酸素化灌流の臓器保存効果

    柿崎 裕太, 宮城 重人, 清水 健司, 熊田 博之, 松村 宗幸, 宮崎 勇希, 福岡 健吾, 植松 智海, 原 康之, 戸子台 和哲, 中西 史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1248-1248　2018/04

    Publisher: (一社)日本外科学会

  445. 肝再生におけるMuse細胞移植の可能性

    伊関 雅裕, 水間 正道, 深瀬 正彦, 小野 智之, 志村 充宏, 鈴木 ゆき恵, 伊勢 一郎, 石田 晶玄, 工藤 克昌, 林 洋毅, 元井 冬彦, 若尾 昌平, 串田 良祐, 亀井 尚, 石田 孝宣, 内藤 剛, 出澤 真理, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1249-1249　2018/04

    Publisher: (一社)日本外科学会

  446. 膵頭十二指腸切除術における周術期管理標準化は術後合併症に影響を与えるか? 日本膵切研究会アンケート調査結果報告

    里井 壯平, 山本 智久, 吉富 秀幸, 元井 冬彦, 廣野 誠子, 藤井 努, 和田 慶太, 有光 秀仁, 庄 雅之, 松本 逸平, 平野 聡, 柳本 泰明, 大塚 将之, 海野 倫明, 山上 裕機, 權 雅憲

    日本外科学会定期学術集会抄録集　118回　1285-1285　2018/04

    Publisher: (一社)日本外科学会

  447. 膵頭部癌・遠位胆管癌の鑑別診断を可能とするタンパク質バイオマーカーの同定

    竹浪 努, 前田 晋平, 唐澤 秀明, 鈴木 貴, 高舘 達之, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1354-1354　2018/04

    Publisher: (一社)日本外科学会

  448. 膵頭十二指腸切除における動脈合併切除再建の安全性と当科における工夫

    宮城 重人, 中西 史, 原 康之, 中西 渉, 戸子台 和哲, 宮澤 恒持, 清水 健司, 植松 智海, 森川 孝則, 元井 冬彦, 石田 孝宣, 後藤 昌史, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1367-1367　2018/04

    Publisher: (一社)日本外科学会

  449. 原発性大腸癌イレウスに対するBridge to Surgeryとしての大腸ステントの有効性の検討

    神山 篤史, 乙供 茂, 梶原 大輝, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1503-1503　2018/04

    Publisher: (一社)日本外科学会

  450. 腹腔鏡下幽門側胃切除における予後規定因子の検討

    武者 宏昭, 村上 恵, 井本 博文, 鈴木 秀幸, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1558-1558　2018/04

    Publisher: (一社)日本外科学会

  451. 重症急性胆嚢炎の治療戦略

    大塚 英郎, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1691-1691　2018/04

    Publisher: (一社)日本外科学会

  452. 当院における病的肥満症に対する減量手術の治療成績

    井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 長尾 宗紀, 渡辺 和宏, 工藤 克昌, 内藤 剛, 亀井 尚, 石田 孝宣, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　1924-1924　2018/04

    Publisher: (一社)日本外科学会

  453. 食道胃接合部癌の縦隔リンパ節至適郭清範囲に対する検討

    瓶子 隆弘, 小野寺 優, 石田 裕嵩, 丸山 祥太, 櫻井 直, 谷山 裕亮, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　1961-1961　2018/04

    Publisher: (一社)日本外科学会

  454. 肝門部領域胆管癌における腹腔洗浄細胞診の意義

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 畠 達夫, 有明 恭平, 石田 晶玄, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 石田 孝宣, 亀井 尚, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2032-2032　2018/04

    Publisher: (一社)日本外科学会

  455. メタボロミクスを用いた乳癌組織におけるメチオニン代謝特性の解明とメチオニンPETへの応用の可能性

    原田 成美, 多田 寛, 渡部 剛, 宮下 穰, 濱中 洋平, 佐藤 章子, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　118回　2131-2131　2018/04

    Publisher: (一社)日本外科学会

  456. cT4食道癌に対する化学放射線治療後の外科手術の治療成績

    小野寺 優, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 丸山 祥太, 石田 裕嵩, 石田 孝宣, 内藤 剛, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　2324-2324　2018/04

    Publisher: (一社)日本外科学会

  457. マップ作成によるクローン病狭窄病変好発部位の検討

    鈴木 秀幸, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 唐澤 秀明, 村上 恵, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2343-2343　2018/04

    Publisher: (一社)日本外科学会

  458. 手術を要した腸管型ベーチェット病の再発形式と長期予後

    伊勢 一郎, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 唐澤 秀明, 鈴木 秀幸, 武者 宏昭, 元井 冬彦, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2344-2344　2018/04

    Publisher: (一社)日本外科学会

  459. Runx1エンハンサーは膵臓において幹/プロジェニター細胞をマークする

    佐藤 英昭, 山村 明寛, 松尾 純一, 木村 俊一, 青木 豪, Lim Yi Hui Melissa, 須田 一人, 内藤 剛, 石田 孝宣, 亀井 尚, 大里 元美, 海野 倫明, 伊藤 嘉明

    日本外科学会定期学術集会抄録集　118回　2449-2449　2018/04

    Publisher: (一社)日本外科学会

  460. Stomatin like protein 2はEMTを介した膵癌細胞の移動浸潤能を制御する

    有明 恭平, 党 超, 大塚 英郎, 元井 冬彦, 水間 正道, 林 洋毅, 深瀬 耕二, 益田 邦洋, 高舘 達之, 中川 圭, 森川 孝則, 畠 達夫, 石田 孝宣, 亀井 尚, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　118回　2454-2454　2018/04

    Publisher: (一社)日本外科学会

  461. 多臓器の幹細胞におけるRunx1エンハンサーとLgr5の関与

    山村 明寛, 松尾 純一, 佐藤 英昭, Lim Yi Hui Melissa, Mon Naing Naing, Dede Liana Heng, Hosain Md Zakir, 青木 豪, 内藤 剛, 亀井 尚, Yeoh Khay Guan, 海野 倫明, 大里 元美, 伊藤 嘉明

    日本外科学会定期学術集会抄録集　118回　2467-2467　2018/04

    Publisher: (一社)日本外科学会

  462. ハイブリッド手術室を用いた新たな外科手術の試み

    原 康之, 宮城 重人, 中西 史, 中西 渉, 宮澤 恒持, 植松 智海, 清水 健司, 赤松 大二朗, 後藤 均, 海野 倫明, 亀井 尚

    日本外科学会定期学術集会抄録集　118回　2540-2540　2018/04

    Publisher: (一社)日本外科学会

  463. 肝門部領域胆管癌の術前診療 肝門部領域胆管癌にマッピングバイオプシーがもたらすもの

    中川 圭, 菅野 敦, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A122-A122　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  464. 慢性膵炎診療の現状と課題 当科における慢性膵炎手術の検討

    佐藤 英昭, 石田 晶玄, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A128-A128　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  465. IPMNの新展開 血液中の血球細胞と蛋白成分から得た炎症性マーカーは膵管内乳頭粘液性腺癌(IPMC)の予測診断に有用か?

    畠 達夫, 水間 正道, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A179-A179　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  466. 基礎研究から紐解く膵・胆道の恒常性とその破綻 膵切後脂肪肝の基礎的・臨床的検討

    石田 晶玄, 坂田 直昭, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A188-A188　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  467. クローン病における再(再々)手術率の検討および頻回の再手術例に対する新吻合法の有用性の検討

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A257-A257　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  468. CA19-9正常膵癌の検討

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 下瀬川 徹, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A288-A288　2018/04

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  469. 再建困難例に対する肝移植の工夫 特に動脈再建について

    宮城 重人, 亀井 尚, 海野 倫明

    肝臓　59　(Suppl.1)　A534-A534　2018/04

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

  470. 肥満治療の最前線 新規薬剤開発から外科治療(Forefront research into obesity management: from development of novel agents to surgical therapy Current status and future perspective of surgical treatment for obesity and diabetes in Japan)

    内藤 剛, 井本 博文, 田中 直樹, 元井 冬彦, 亀井 尚, 海野 倫明

    糖尿病　61　(Suppl.1)　S-95　2018/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  471. 【胆嚢癌-術前診断に応じた治療を再考する-】 胆嚢癌の鑑別診断と進展度診断 超音波内視鏡

    菅野 敦, 正宗 淳, 鍋島 立秀, 本郷 星仁, 滝川 哲也, 三浦 晋, 濱田 晋, 菊田 和宏, 粂 潔, 下瀬川 徹, 海野 倫明

    胆と膵　39　(3)　217-227　2018/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  472. クローン病における再(再々)手術率の検討および頻回の再手術例に対する新吻合法の有用性の検討

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　115　(臨増総会)　A257-A257　2018/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  473. 胃GISTに対する外科治療(Surgical treatment for gastric gastrointestinal stromal tumors)

    橘 知睦, 杉沢 徳彦, 武者 宏昭, 相澤 卓, 工藤 克昌, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　440-440　2018/03

    Publisher: (一社)日本胃癌学会

  474. 重度の全身疾患を有する胃癌手術症例の治療成績(Surgical outcomes after gastrectomy for gastric cancer in the patients with severe systemic diseases)

    相澤 卓, 杉沢 徳彦, 武者 宏昭, 橘 知睦, 工藤 克昌, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　516-516　2018/03

    Publisher: (一社)日本胃癌学会

  475. 胃全摘後の体重減少と術後るいそうのリスク因子(Body weight loss after total gastrectomy and risk factors for emaciation)

    田中 直樹, 武者 宏昭, 杉沢 徳彦, 井本 博文, 青木 豪, 工藤 克昌, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　523-523　2018/03

    Publisher: (一社)日本胃癌学会

  476. 【胆嚢癌-術前診断に応じた治療を再考する-】 はじめに 術前診断に応じた胆嚢癌治療

    海野 倫明, 中川 圭, 林 洋毅, 元井 冬彦, 大塚 英郎

    胆と膵　39　(3)　187-189　2018/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  477. 【診療ガイドライン最新版による膵癌診療アップデート】 外科治療 切除 膵癌切除後の経過観察はどのようにするか? 切除後の腫瘍マーカー測定の意義

    元井 冬彦, 海野 倫明

    肝・胆・膵　76　(3)　393-401　2018/03

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  478. 家族性大腸腺腫症に併存した十二指腸腺腫に対する内視鏡補助下十二指腸局所切除術の1例

    平嶋 倫亮, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　45　(3)　518-520　2018/03

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  479. 腸管型ベーチェット病手術例の長期予後の検討

    伊勢 一郎, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 唐澤 秀明, 鈴木 秀幸, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　71　(3)　133-138　2018/03

    Publisher: (一社)日本大腸肛門病学会

    DOI： 10.3862/jcoloproctology.71.133 　

    ISSN： 0047-1801

  480. 【合併症ゼロを目指した最新の低侵襲内視鏡外科手術】 膵臓・脾臓 腹腔鏡下膵体尾部切除術

    高舘 達之, 森川 孝則, 石田 晶玄, 元井 冬彦, 内藤 剛, 海野 倫明

    手術　72　(4)　537-543　2018/03

    Publisher: 金原出版(株)

    DOI： 10.18888/op.0000000643 　

    ISSN： 0037-4423

  481. 膵頭十二指腸切除術症例におけるControlling Nutritional Statusを用いた術前栄養状態と術後合併症に関する検討

    石田 晶玄, 元井 冬彦, 佐藤 英昭, 村上 恵, 前田 晋平, 工藤 克昌, 大沼 忍, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　33　(1)　641-646　2018/03

    Publisher: (株)ジェフコーポレーション

    DOI： 10.11244/jspen.33.641 　

    ISSN： 2189-0161

    eISSN： 2189-017X

  482. 【肝胆膵がん】 膵がんの術前・術後 補助療法のエビデンス

    元井 冬彦, 海野 倫明

    腫瘍内科　21　(3)　280-287　2018/03

    Publisher: (有)科学評論社

    ISSN： 1881-6568

  483. 胃GISTに対する外科治療(Surgical treatment for gastric gastrointestinal stromal tumors)

    橘 知睦, 杉沢 徳彦, 武者 宏昭, 相澤 卓, 工藤 克昌, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　440-440　2018/03

    Publisher: (一社)日本胃癌学会

  484. 重度の全身疾患を有する胃癌手術症例の治療成績(Surgical outcomes after gastrectomy for gastric cancer in the patients with severe systemic diseases)

    相澤 卓, 杉沢 徳彦, 武者 宏昭, 橘 知睦, 工藤 克昌, 田中 直樹, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　516-516　2018/03

    Publisher: (一社)日本胃癌学会

  485. 胃全摘後の体重減少と術後るいそうのリスク因子(Body weight loss after total gastrectomy and risk factors for emaciation)

    田中 直樹, 武者 宏昭, 杉沢 徳彦, 井本 博文, 青木 豪, 工藤 克昌, 内藤 剛, 亀井 尚, 海野 倫明

    日本胃癌学会総会記事　90回　523-523　2018/03

    Publisher: (一社)日本胃癌学会

  486. 肝移植後急性腹症の検討

    原康之, 宮城重人, 中西史, 中西渉, 西村隆一, 植松智海, 清水健司, 熊田博之, 海野倫明, 亀井尚

    日本腹部救急医学会雑誌　38　(2)　329　2018/02/08

    ISSN： 1340-2242

  487. A randomized phase II study of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab for previously untreated, liver-limited metastatic colorectal cancer that is unsuitable for resection (ATOM trial).

    Hiroyuki Uetake, Yasunori Emi, Takeharu Yamanaka, Kei Muro, Eiji Oki, Takao Takahashi, Takeshi Nagasaka, Etsuro Hatano, Hitoshi Ojima, Dai Manaka, Tetsuya Kusumoto, Yu Katayose, Toshiyoshi Fujiwara, Kazuhiro Yoshida, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Kenichi Sugihara, Yoshihiko Maehara

    JOURNAL OF CLINICAL ONCOLOGY　36　(4)　2018/02

    DOI： 10.1200/JCO.2018.36.4_suppl.734 　

    ISSN： 0732-183X

    eISSN： 1527-7755

  488. 腹部大動脈瘤を伴ったマージナルドナーから脳死膵腎同時移植を施行した1例

    清水健司, 宮城重人, 楳田祐三, 中西史, 原康之, 中西渉, 西村隆一, 植松智海, 熊田博之, 柿崎裕太, 海野倫明, 亀井尚, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　45th　74　2018/02

  489. ドナー膵組織のマトリックス組成に対応するテーラーメイド型膵島分離法の確立へ向けた試み

    宮崎勇希, 猪村武弘, 村山和隆, 山形洋平, 前田浩, 渡邉君子, 稲垣明子, 宮城重人, 内藤剛, 海野倫明, 亀井尚, 里見進, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　45th　65　2018/02

  490. 東北大学病院における膵腎同時移植10例の現状と,マージナルドナー利用に向けた今後の基準の検討

    宮城重人, 中西史, 原康之, 中西渉, 西村隆一, 清水健司, 植松智海, 植松智海, 熊田博之, 柿崎裕太, 海野倫明, 亀井尚, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　45th　42　2018/02

  491. 膵島を用いた細胞生着促進因子を同定する有用な解析モデルの構築

    齋藤純健, 猪村武弘, 後藤めぐみ, 稲垣明子, FATHI Ibrahim, 小笠原弘之, 宮城重人, 亀井尚, 海野倫明, 里見進, 安波洋一, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　45th　65　2018/02

  492. 生体肝移植後のEdwardsiella tardaによる敗血症症例の考察

    清水 健司, 原 康之, 植松 智海, 宮澤 恒持, 中西 渉, 戸子台 和哲, 中西 史, 宮城 重人, 海野 倫明, 亀井 尚, 里見 進

    移植　52　(6)　559-559　2018/02

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  493. 破骨細胞様巨細胞を伴った肝血管肉腫の1例

    水井 崇浩, 村上 圭吾, 原 康之, 宮城 重人, 内藤 剛, 海野 倫明, 亀井 尚

    日本臨床外科学会雑誌　79　(2)　382-389　2018/02

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  494. 【肥満と消化器疾患】 減量手術・代謝改善手術

    田中 直樹, 井本 博文, 海野 倫明, 内藤 剛

    消化器・肝臓内科　3　(2)　203-208　2018/02

    Publisher: (有)科学評論社

    ISSN： 2432-3446

  495. 2年間の化学療法でDown-Stagingし根治切除を施行した腹膜転移を伴う膵頭部癌の1例

    初沢 悠人, 水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 高舘 達之, 大塚 英郎, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 菅野 敦, 下瀬川 徹, 海野 倫明

    癌と化学療法　45　(2)　347-349　2018/02

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  496. 消化管静脈瘤の診断と治療(異所性静脈瘤や手術後の静脈瘤を含む) 当科で経験した術後肝外門脈閉塞、門脈圧亢進症に伴う異所性静脈瘤の検討

    伊関 雅裕, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 菅野 敦, 下瀬川 徹, 海野 倫明

    日本腹部救急医学会雑誌　38　(2)　330-330　2018/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  497. 食道癌小腸転移からの消化管出血で緊急手術を要した1例

    三田地 克昂, 有明 恭平, 高舘 達之, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本腹部救急医学会雑誌　38　(2)　376-376　2018/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  498. 当科における臨時・緊急膵手術症例の検討

    森川 孝則, 元井 冬彦, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大沼 忍, 大塚 英郎, 坂田 直昭, 武者 宏昭, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　38　(2)　444-444　2018/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  499. 出血が少なく使いやすい皮下デバイスを目指して:糖尿病マウスにおけるRGD基含有ヒトI型コラーゲン素材による皮下膵島移植についての報告

    植松智海, 稲垣明子, 中村保宏, 後藤めぐみ, 猪村武弘, 猪村梢, 五十嵐康宏, FATHI Ibrahim, 宮城重人, 亀井尚, 内藤剛, 海野倫明, 里見進, 後藤昌史, 後藤昌史

    日本膵・膵島移植研究会プログラム・抄録集　45th　69　2018/02

  500. RGD基を含有する新規コラーゲン素材のリコンビナントペプチド(RCP)を用いた皮下膵島移植の試み

    植松 智海, 稲垣 明子, 中村 保宏, 後藤 めぐみ, 猪村 武弘, 猪村 梢, 五十嵐 康宏, 亀井 尚, 海野 倫明, 里見 進, 後藤 昌史

    移植　52　(6)　565-565　2018/02

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  501. 再生不良性貧血治療中に発症したメッケル憩室出血の一切除例

    市川 英孝, 唐澤 秀明, 村上 恵, 工藤 克昌, 大沼 忍, 林 洋毅, 中川 圭, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　38　(2)　376-376　2018/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  502. 移植前肝細胞に対するADP/ATP ratioを用いた簡便で有用な評価法の確立

    松村宗幸, 猪村武弘, 小笠原弘之, 福岡健吾, 稲垣明子, 宮城重人, 大橋一夫, 海野倫明, 亀井尚, 里見進, 後藤昌史, 後藤昌史

    日本再生医療学会総会(Web)　17th　2018

  503. The Current Trend of Anorectal Cancer Surveillance in Patients with Crohn's Disease: A Questionnaire Survey of Japanese Specialists

    渡辺和宏, 倉地清隆, 水島恒和, 水島恒和, 亀山仁史, 佐々木巌, 杉田昭, 根津理一郎, 舟山裕士, 福島浩平, 福島浩平, 内藤剛, 海野倫明, 二見喜太郎

    日本大腸肛門病学会雑誌(Web)　71　(7)　283‐290(J‐STAGE)　2018

    DOI： 10.3862/jcoloproctology.71.283 　

    ISSN： 1882-9619

  504. 【Borderline resectable膵癌に対する集学的治療】 Borderline resectable膵癌に対する治療前PET SUVmax値を用いた層別化:術前治療の適応に関する考察

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    癌の臨床　63　(5)　397-403　2018/01

    Publisher: (株)篠原出版新社

    ISSN： 0021-4949

  505. 膵癌術前治療における骨格筋量の変化と予後の検討

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 有明 恭平, 石田 晶玄, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　33　(Suppl.)　273-273　2018/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  506. 膵癌切除後の周術期栄養不良例の臨床的特徴

    元井 冬彦, 畠 達夫, 有明 恭平, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　33　(Suppl.)　303-303　2018/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  507. 膵癌患者における術前modified Glasgow Prognostic scoreの意義

    伊関 雅裕, 水間 正道, 志村 充広, 畠 達夫, 有明 恭平, 石田 晶玄, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　33　(Suppl.)　325-325　2018/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  508. 膵頭十二指腸切除術後の胃内容排泄遅延の有無と食事開始時期・退院時の栄養状態の関係について

    三浦 温子, 高橋 友貴子, 佐藤 菜保子, 深谷 真理子, 石田 晶玄, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　33　(Suppl.)　375-375　2018/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  509. A CASE OF LINEA ALBA HERNIA CAUSED BY PREGNANCY THAT WAS REPAIRED USING THE ENDOSCOPIC COMPONENTS SEPARATION TECHNIQUE

    伊勢 一郎, 青木 豪, 田中 直樹, 武者 宏昭, 海野 倫明, 内藤 剛

    日本臨床外科学会雑誌　79　(11)　2364-2369　2018

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  510. RGD基(Arg‐Gly‐Asp)含有するヒトI型コラーゲン素材の皮下デバイスを使用した皮下膵島移植法

    植松智海, 稲垣明子, 中村保宏, 後藤めぐみ, 猪村武弘, 猪村梢, 五十嵐康宏, IBRAHIM Fathi, 宮城重人, 亀井尚, 海野倫明, 里見進, 後藤昌史, 後藤昌史

    日本再生医療学会総会(Web)　17th　ROMBUNNO.O‐46‐6 (WEB ONLY)　2018

  511. 高浸透圧を利用したslug法(ナメクジ法)によるストーマ脱・直腸脱・浮腫腸管ストーマ造設の手技

    渡辺 和宏, 神山 篤史, 唐澤 秀明, 鈴木 秀幸, 大沼 忍, 武者 宏昭, 渡邊 涼子, 亀井 尚, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　34　(1)　214-214　2018/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  512. Drug delivery of oral anti-cancer fluoropyrimidine agents

    Koh Miura, Hiroshi Shima, Naoko Takebe, Julie Rhie, Kennichi Satoh, Yoichiro Kakugawa, Masayuki Satoh, Makoto Kinouchi, Kuniharu Yamamoto, Yasuhiro Hasegawa, Masaaki Kawai, Kousuke Kanazawa, Tsuneaki Fujiya, Michiaki Unno, Ryuichi Katakura

    Expert Opinion on Drug Delivery　14　(12)　1355-1366　2017/12/02

    Publisher: Taylor and Francis Ltd

    DOI： 10.1080/17425247.2017.1316260 　

    ISSN： 1744-7593 1742-5247

  513. 腹腔鏡補助下膵中央切除術を施行した膵体部Solid pseudopapillary neoplasmの1例

    高舘 達之, 森川 孝則, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP164-06　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  514. 【周術期薬物療法の新しい戦略】 各臓器がんに対する周術期治療 エビデンス・展望 膵がんに対する外科治療と術前術後補助療法

    元井 冬彦, 海野 倫明

    腫瘍内科　20　(6)　584-591　2017/12

    Publisher: (有)科学評論社

    ISSN： 1881-6568

  515. 膵癌患者の術後栄養状態とQOLの経時的評価

    佐藤 菜保子, 元井 冬彦, 有明 恭平, 中川 圭, 川口 桂, 佐藤 昌美, 片寄 友, 佐藤 冨美子, 海野 倫明

    膵臓　32　(6)　873-881　2017/12

    Publisher: 日本膵臓学会

    DOI： 10.2958/suizo.32.873 　

    ISSN： 0913-0071

  516. 腹腔鏡下肝切除時代の肝離断法 腹腔鏡下肝部分切除術における腫瘍局在別肝離断法の工夫

    森川 孝則, 石田 晶玄, 高館 達之, 畠 達夫, 伊関 雅裕, 原 康之, 中西 史, 青木 豪, 大塚 英郎, 林 洋毅, 中川 圭, 宮城 重人, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　WS5-4　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  517. Current status and future perspective of bariatric and metabolic surgery 減量・代謝改善手術の糖尿病改善効果とその機序

    内藤 剛, 田中 直樹, 井本 博文, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 武者 宏昭, 亀井 尚, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　S-4　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  518. 膵体尾部境界に関する外科解剖的考察

    石田 晶玄, 森川 孝則, 高舘 達之, 畠 達夫, 青木 豪, 工藤 克昌, 大沼 忍, 深瀬 耕二, 林 洋毅, 中川 圭, 武者 宏昭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP074-01　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  519. 横行結腸間膜原発長径24cm消化管外消化管間質腫瘍の1例

    竹浪 努, 前田 晋平, 唐澤 秀明, 元井 冬彦, 内藤 剛, 海野 倫明

    外科　79　(13)　1400-1404　2017/12

    Publisher: (株)南江堂

    DOI： 10.15106/j_geka79_1400 　

    ISSN： 0016-593X

  520. 【究極のこだわり 直腸癌に対する腹腔鏡下手術】 男性狭骨盤症例の腹腔鏡下低位前方切除術

    大沼 忍, 内藤 剛, 村上 恵, 鈴木 秀幸, 井本 博文, 山村 明寛, 唐澤 秀明, 神山 篤史, 青木 豪, 渡辺 和宏, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 海野 倫明

    消化器外科　40　(13)　1765-1771　2017/12

    Publisher: (株)へるす出版

    ISSN： 0387-2645

  521. 家族性大腸腺腫症に対する腹腔鏡下大腸全摘術

    大沼 忍, 渡辺 和宏, 長尾 宗紀, 唐澤 秀明, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　SF010-05　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  522. 当院における腹壁瘢痕ヘルニアに対する腹腔鏡下手術

    青木 泰孝, 青木 豪, 井本 博文, 唐澤 秀明, 石田 晶玄, 工藤 克昌, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 森川 孝則, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　SF069-01　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  523. 当院における病的肥満症に対する減量手術の治療成績の検討

    井本 博文, 田中 直樹, 武者 宏昭, 大沼 忍, 長尾 宗紀, 工藤 克昌, 青木 豪, 渡辺 和宏, 唐澤 秀明, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　SF085-02　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  524. 肥満患者腹腔鏡手術におけるポートサイト閉鎖手技の工夫

    安藤 涼平, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 大沼 忍, 武者 宏昭, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　SF085-07　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  525. 肥満患者における結腸癌に対する腹腔鏡手術

    小野 智之, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　SF103-06　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  526. 鼠径ヘルニアに合併したスピーゲルヘルニアの一例

    青木 豪, 井本 博文, 高舘 達之, 唐澤 秀明, 石田 晶玄, 工藤 克昌, 渡辺 和宏, 田中 直樹, 大沼 忍, 武者 宏昭, 森川 孝則, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP006-03　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  527. 開腹手技と腹腔鏡手技の利点を組み合わせた重症潰瘍性大腸炎に対するHALS大腸亜全摘術の術野展開

    渡辺 和宏, 長尾 宗紀, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP054-06　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  528. 腹腔鏡下幽門側切除術の短期成績におけるリスク因子の検討

    田中 直樹, 武者 宏昭, 井本 博文, 青木 豪, 工藤 克昌, 唐澤 秀明, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP103-05　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  529. 胃癌・大腸癌の重複癌に対する腹腔鏡下同時切除症例の検討

    相澤 卓, 唐澤 秀明, 杉沢 徳彦, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP105-09　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  530. パルスウォータージェットメスの腹腔鏡下大腸切除への応用

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 亀井 尚, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP127-01　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  531. 腹腔鏡下幽門側胃切除術における併施手術施行症例の検討

    武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 大沼 忍, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP168-05　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  532. 当科における胃GISTに対する腹腔鏡下手術の治療成績の検討

    小野 翼, 井本 博文, 武者 宏昭, 大沼 忍, 田中 直樹, 長尾 宗紀, 渡辺 和宏, 工藤 克昌, 青木 豪, 唐澤 秀明, 杉沢 徳彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本内視鏡外科学会雑誌　22　(7)　EP211-04　2017/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  533. Runx1エンハンサーは多臓器において幹細胞マーカーとなる

    山村 明寛, 松尾 純一, 佐藤 英昭, Lim Yi Hui Melissa, Mon Naing Naing, Heng Dede Liana, Hosain Md Zakir, 海野 倫明, Guan Yeoh Khay, 大里 元美, 伊藤 嘉明

    生命科学系学会合同年次大会　2017年度　[3AT11-0808)]　2017/12

    Publisher: 生命科学系学会合同年次大会運営事務局

  534. 消化器領域の神経内分泌腫瘍 3.消化器領域における神経内分泌腫瘍/神経内分泌癌に対する薬物治療の実際 1)消化管・膵神経内分泌腫瘍への薬物治療をどう進めていくか?

    大塚英郎, 青木豪, 海野倫明

    臨床腫瘍プラクティス　13　(4)　299‐304　2017/11/10

    ISSN： 1880-3083

  535. RGD基(Arg‐Gly‐Asp)含有コラーゲン素材を使用した皮下膵島移植における血管新生と移植効率についての報告

    植松智海, 稲垣明子, 中村保宏, 後藤めぐみ, 猪村武弘, 猪村梢, 五十嵐康宏, 亀井尚, 海野倫明, 里見進, 後藤昌史, 後藤昌史

    Organ Biology　24　(3)　78　2017/11/10

    ISSN： 1340-5152

  536. Neoadjuvant therapy for resectable pancreatic cancer

    72　(12)　1306-1310　2017/11

    Publisher: 医学書院

    ISSN： 0386-9857

  537. 小児肝移植後長期経過中におけるカルシニューリン阻害薬血中濃度がドナー特異的抗HLA抗体出現に与える影響

    戸子台 和哲, 清水 健司, 宮澤 恒持, 中西 渉, 原 康之, 中西 史, 宮城 重人, 亀井 尚, 海野 倫明

    移植　52　(4-5)　425-426　2017/11

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  538. 生体肝移植ドナー手術後における血小板数減少と肝再生との関連についての検討

    宮澤 恒持, 原 康之, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 植松 智海, 清水 健司, 亀井 尚, 海野 倫明, 後藤 昌史

    移植　52　(4-5)　442-442　2017/11

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  539. RENO-PORTAL吻合を施行した小児生体肝移植

    小笠原 弘之, 中西 史, 清水 健司, 宮澤 恒持, 中西 渉, 戸子台 和哲, 原 康之, 宮城 重人, 亀井 尚, 海野 倫明

    移植　52　(4-5)　462-462　2017/11

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  540. どんな手術でもパスにできます Frey手術クリニカルパスの経験

    石田 晶玄, 元井 冬彦, 坂田 直昭, 武者 宏昭, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 亀井 尚, 海野 倫明

    日本クリニカルパス学会誌　19　(4)　412-412　2017/11

    Publisher: 日本クリニカルパス学会

    ISSN： 2187-6592

    eISSN： 2436-1046

  541. 腸管内腔へ穿破し消化管出血を来した小腸平滑筋肉腫の1例

    土屋 堯裕, 田中 直樹, 長尾 宗紀, 渡辺 和宏, 井本 博文, 大沼 忍, 武者 宏昭, 渡辺 みか, 村上 圭吾, 藤島 史喜, 元井 冬彦, 内藤 剛, 海野 倫明

    癌と化学療法　44　(12)　1068-1070　2017/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  542. 切除不能膵癌に対するGemcitabine+Nab-Paclitaxel療法を用いた集学的治療

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    癌と化学療法　44　(12)　1241-1244　2017/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  543. 腹膜播種と卵巣転移を有した上行結腸癌に対し化学療法後に治癒切除を施行した1例

    望月 保志, 唐澤 秀明, 下平 秀樹, 大沼 忍, 渡辺 和宏, 前田 晋平, 長尾 宗紀, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　44　(12)　1711-1713　2017/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  544. 腹膜転移を有する膵頭部癌に対してAdjuvant Surgeryを企図し切除し得た1例

    客本 ゆき恵, 高舘 達之, 水間 正道, 畠 達夫, 伊関 雅裕, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 菅野 敦, 下瀬川 徹, 海野 倫明

    癌と化学療法　44　(12)　1880-1882　2017/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  545. 肛門管扁平上皮癌に対する集学的治療

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    癌と化学療法　44　(12)　2009-2010　2017/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  546. Neoadjuvant chemotherapy with gemcitabine and S1 (GS) for pancreatic cancer planned resection

    Fuyuhiko Motoi, Michiaki Unno

    ANNALS OF ONCOLOGY　28　2017/10

    ISSN： 0923-7534

    eISSN： 1569-8041

  547. 非典型的な画像所見を呈した肝reactive lymphoid hyperplasiaの一若年例

    宮崎 勇希, 原 康之, 宮城 重人, 中西 史, 戸子台 和哲, 中西 渉, 村上 圭吾, 海野 倫明, 亀井 尚

    肝臓　58　(10)　559-566　2017/10

    Publisher: (一社)日本肝臓学会

    ISSN： 0451-4203

    eISSN： 1881-3593

  548. 生体肝移植後に発熱と肝機能異常で発症したEdwardsiella tardaによる敗血症の一例

    植松 智海, 原 康之, 清水 健司, 宮澤 恒持, 中西 渉, 戸子台 和哲, 中西 史, 宮城 重人, 海野 倫明, 亀井 尚

    日本外科感染症学会雑誌　14　(5)　616-616　2017/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  549. 合併症ゼロを目指した手術(胆膵) 合併症の軽減を目指した肝門部領域胆管癌手術

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 有明 恭平, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　376-376　2017/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.78.376 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  550. シミュレーション手術の新展開 当科における腹腔鏡下膵尾側切除術の術前シミュレーション、術中ナビゲーションの取組み

    石田 晶玄, 森川 孝則, 高舘 達之, 益田 邦洋, 青木 豪, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　401-401　2017/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.78.401 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  551. Borderline resectable膵癌に対する治療戦略 動脈接触を伴う膵癌に対する化学放射線療法の有用性

    林 洋毅, 元井 冬彦, 水間 正道, 森川 孝則, 中川 圭, 坂田 直昭, 大塚 英郎, 深瀬 耕二, 石田 晶玄, 益田 邦洋, 有明 恭平, 前田 晋平, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　429-429　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  552. 動脈非再建の臓器温存腹腔動脈幹切除術を施行した後腹膜平滑筋肉腫の1例

    三田地 克昂, 水間 正道, 林 洋毅, 畠 達夫, 有明 恭平, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　571-571　2017/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.78.571 　

    ISSN： 1345-2843

  553. 膵癌術前治療の組織学的治療効果と予後との関係

    水間 正道, 元井 冬彦, 畠 達夫, 高舘 達之, 有明 恭平, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　679-679　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  554. 膵管拡張範囲に基づいた主膵管型膵管内乳頭粘液性腫瘍(IPMN)の術式選択と治療方針

    畠 達夫, 水間 正道, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　705-705　2017/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.78.705 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  555. 尋常性天疱瘡を合併した膵体部癌に対し術前治療後に腹腔動脈合併膵体尾部切除術を施行した1例

    千葉 和治, 水間 正道, 大塚 英郎, 畠 達夫, 高館 達之, 前田 晋平, 有明 恭平, 林 洋毅, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　744-744　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  556. 2区域以上の肝切除例における敗血症の発症率と長期予後

    片寄 友, 伊勢 一郎, 林 洋毅, 武藤 満完, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科感染症学会雑誌　14　(5)　641-641　2017/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  557. 膵頭十二指腸切除術後の腹腔内膿瘍からメタロβラクタマーゼ産生Enterococcus cloacaeが検出された1例

    永間 正道, 畠 達夫, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 坂田 直昭, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本外科感染症学会雑誌　14　(5)　651-651　2017/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

    eISSN： 2434-0103

  558. 「それぞれの癌」診断・治療の現状と展望 膵臓癌 切除可能膵癌に対する術前治療

    海野 倫明, 元井 冬彦

    日本癌治療学会学術集会抄録集　55回　OSY2-4　2017/10

    Publisher: (一社)日本癌治療学会

  559. 「それぞれの癌」難治性癌に対する治療戦略 肝・胆・膵 肝外胆管癌の治療戦略

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　WS11-4　2017/10

    Publisher: (一社)日本癌治療学会

  560. 膵癌におけるUICC TNM分類第8版の予後的特徴 旧分類との比較

    水間 正道, 元井 冬彦, 畠 達夫, 高舘 達之, 有明 恭平, 前田 晋平, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P52-1　2017/10

    Publisher: (一社)日本癌治療学会

  561. 膵管内乳頭粘液性腫瘍(IPMN)術後の残膵病変発生のリスクとサーベイランス

    畠 達夫, 水間 正道, 伊関 雅裕, 高舘 達之, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 元井 冬彦, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P52-5　2017/10

    Publisher: (一社)日本癌治療学会

  562. 画像診断陰性・転移膵癌に対する集学的二期的切除の有効性

    元井 冬彦, 高館 達之, 前田 晋平, 有明 恭平, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P53-3　2017/10

    Publisher: (一社)日本癌治療学会

  563. 膵癌外科切除後患者のCONUT値による栄養状態ならびにQOLの経時的評価

    佐藤 菜保子, 元井 冬彦, 有明 恭平, 中川 圭, 川口 桂, 佐藤 昌美, 片寄 友, 佐藤 冨美子, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P110-4　2017/10

    Publisher: (一社)日本癌治療学会

  564. 浸潤性膵管癌術後7年無再発の長期生存者に発症し、高CPK血症を契機に診断された原発性甲状腺機能低下症の1例

    元井 冬彦, 村上 泰介, 阿部 裕, 中島 範昭, 石田 孝宣, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　791-791　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  565. 炎症性腸疾患の治療戦略 当科における重症潰瘍性大腸炎に対する手術アプローチの選択と、安全な術野展開に重点をおいたHALS大腸亜全摘術の手術手技について

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　420-420　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  566. 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除術の手技と工夫

    武者 宏昭, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 大沼 忍, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　504-504　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  567. 閉塞性大腸癌に対する姑息手術としてのIleostomyとColostomyの比較

    鈴木 ゆき恵, 唐澤 秀明, 大沼 忍, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　559-559　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  568. 同時性腹膜播種を有する大腸癌の治療成績

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　640-640　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  569. 全身麻酔不能な肺高血圧症を合併した繰り返す閉鎖孔ヘルニア嵌頓に対して、整復後に待機的前方アプローチで修復した1例

    伊勢 一郎, 田中 直樹, 鈴木 秀幸, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 武者 宏昭, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(増刊)　930-930　2017/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  570. 原発性小腸癌に対する化学療法の現況

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P36-5　2017/10

    Publisher: (一社)日本癌治療学会

  571. 他臓器浸潤直腸癌に対する術前化学放射線療法の有用性

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　55回　P152-4　2017/10

    Publisher: (一社)日本癌治療学会

  572. 胃の主細胞に幹細胞活性が存在し胃癌の起源となりうる

    山村 明寛, 松尾 純一, リムイフイ・メリッサ, ディーディー・リアナヘン, 河府 和義, ザキール・ホサイン, 海野 倫明, ケイグアン・ヨウ, 大里 元美, 伊藤 嘉明

    日本癌学会総会記事　76回　E-2066　2017/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  573. 肥満症に対する内視鏡的治療と腹腔鏡下手術の現状と展望 我が国におけるMetabolic Surgeryの今後の展望

    内藤 剛, 田中 直樹, 海野 倫明

    日本消化器病学会雑誌　114　(臨増大会)　A606-A606　2017/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  574. 肥満症に対する内視鏡的治療と腹腔鏡下手術の現状と展望 我が国におけるMetabolic Surgeryの今後の展望

    内藤 剛, 田中 直樹, 海野 倫明

    Gastroenterological Endoscopy　59　(Suppl.2)　2050-2050　2017/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  575. 新規合成クルクミン誘導体における抗癌剤耐性ABCトランスポーターの抑制効果

    村上 恵, 大沼 忍, 工藤 克昌, 石田 晶玄, 岩渕 好治, 柴田 浩行, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌学会総会記事　76回　J-1014　2017/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  576. Borderline resectable膵癌治療の新たな展開《アンサーパッド》 BR膵癌に対する治療戦略

    林 洋毅, 元井 冬彦, 海野 倫明

    日本消化器病学会雑誌　114　(臨増大会)　A545-A545　2017/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  577. 術前画像診断による十二指腸乳頭部癌リンパ節転移診断

    伊関 雅裕, 中川 圭, 高舘 達之, 益田 邦洋, 深瀬 耕二, 前田 晋平, 有明 恭平, 石田 晶玄, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　114　(臨増大会)　A841-A841　2017/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  578. Borderline resectable膵癌治療の新たな展開 アンサーパッド BR膵癌に対する治療戦略

    林 洋毅, 元井 冬彦, 海野 倫明

    Gastroenterological Endoscopy　59　(Suppl.2)　2007-2007　2017/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  579. プロテオーム解析を用いた膵癌・胆管癌の鑑別を可能にする新規バイオマーカーの同定

    竹浪 努, 唐澤 秀明, 鈴木 貴, 高舘 達之, 林 洋毅, 元井 冬彦, 海野 倫明

    日本癌学会総会記事　76回　P-3333　2017/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  580. 腸腰筋浸潤を伴う進行虫垂粘液嚢胞腺癌に対し根治切除を施行した1例

    金原 圭吾, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 工藤 克昌, 石田 晶玄, 佐藤 聡子, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　50　(9)　754-761　2017/09

    Publisher: (一社)日本消化器外科学会

    DOI： 10.5833/jjgs.2016.0158 　

    ISSN： 0386-9768

  581. 直腸神経内分泌腫瘍に対する手術症例の検討

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(抄録号)　A84-A84　2017/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  582. 前立腺浸潤下部直腸癌に対するMitrofanoff法を用いた膀胱温存手術

    唐澤 秀明, 安達 尚宣, 大沼 忍, 渡辺 和宏, 鈴木 秀幸, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 内藤 剛, 荒井 陽一, 海野 倫明

    日本大腸肛門病学会雑誌　70　(抄録号)　A168-A168　2017/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  583. クローン病の新吻合法(anti-mesenteric cutback end-to-side isoperistaltic anastomosis)についての検討

    渡辺 和宏, 長尾 宗紀, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(抄録号)　A193-A193　2017/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  584. 潰瘍性大腸炎に対する回腸肛門吻合術後の長期経過例の検討

    長尾 宗紀, 渡辺 和宏, 鈴木 秀幸, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(抄録号)　A198-A198　2017/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  585. 腎細胞癌の胆嚢転移の1例

    鍋島 立秀, 菅野 敦, 正宗 淳, 森川 孝則, 中野 絵里子, 三浦 晋, 藤島 史喜, 海野 倫明, 下瀬川 徹

    胆道　31　(3)　640-640　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  586. 遠位胆管癌へのアプローチ 各診療科のコラボレーション 遠位胆管癌切除例の予後不良因子と術後補助化学療法の有用性

    益田 邦洋, 中川 圭, 海野 倫明

    胆道　31　(3)　410-410　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  587. 医学教育におけるVisual Analog Scaleの新しい利用方法の提案

    壹岐 裕子, 工藤 克昌, 野田 雅史, 井本 博文, 松田 安史, 伊藤 拓哉, 海野 倫明

    日本シミュレーション医療教育学会雑誌　5　138-138　2017/08

    Publisher: 日本シミュレーション医療教育学会

    ISSN： 2187-9281

  588. 【膵癌治療の最前線-諸問題の解決にむけた取り組み-】 高齢者膵癌に対する手術適応についての多施設共同研究

    庄 雅之, 長井 美奈子, 村上 義昭, 川井 学, 元井 冬彦, 里井 壮平, 松本 逸平, 本田 五郎, 赤堀 宇広, 中川 顕一, 中村 広太, 海野 倫明, 山上 裕機

    胆と膵　38　(8)　781-788　2017/08

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  589. 当科における二次性肝内結石症に対する治療

    伊関 雅裕, 中川 圭, 高舘 達之, 益田 邦洋, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 菅野 敦, 下瀬川 徹, 海野 倫明

    胆道　31　(3)　508-508　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  590. 肝切除を伴う胆道癌手術における敗血症の検討

    片寄 友, 伊勢 一郎, 林 洋毅, 中川 圭, 森川 孝則, 水間 正道, 大塚 英郎, 武藤 満完, 松村 直樹, 野村 良平, 徳村 弘実, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　31　(3)　529-529　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  591. 肝門部領域胆管癌に対するS-1術後補助化学療法

    深瀬 耕二, 吉町 信吾, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　31　(3)　557-557　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

    eISSN： 1883-6879

  592. 十二指腸乳頭部混合型腺神経内分泌癌(MANEC)の一例

    吉町 信吾, 大塚 英郎, 有明 恭平, 益田 邦洋, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 菅野 敦, 下瀬川 徹, 藤島 史喜, 海野 倫明

    胆道　31　(3)　590-590　2017/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  593. 横行結腸癌に併存し癌性腹膜炎との鑑別を要した結核性腹膜炎の1例

    佐藤 正規, 井本 博文, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　78　(8)　1848-1854　2017/08

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.78.1848 　

    ISSN： 1345-2843

  594. 【がん治療医のための漢方ハンドブック】癌腫別 漢方の使い方 胃癌による胃切除術後における漢方薬の効果

    工藤 克昌, 武者 宏昭, 海野 倫明

    臨床外科　72　(8)　948-951　2017/08

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1407211701 　

    ISSN： 0386-9857

  595. 血管誘導効果を有するRGD基(Arg-Gly-Asp)含有コラーゲン素材を使用した皮下膵島移植法の樹立

    植松 智海, 稲垣 明子, 中村 保宏, 後藤 めぐみ, 猪村 武弘, 五十嵐 康宏, 亀井 尚, 海野 倫明, 里見 進, 後藤 昌史

    移植　52　(総会臨時)　404-404　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  596. 直腸癌手術における予防的尿管ステント挿入の有効性の評価

    金原 圭吾, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏明, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(8)　571-571　2017/08

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  597. 肥満症を合併した前立腺全摘後進行下部直腸癌に対して術前化学放射線療法・術前減量を行い膀胱温存を試みた一例

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本大腸肛門病学会雑誌　70　(8)　583-583　2017/08

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  598. 直腸癌手術におけるDiverting Stomaの有効性の検討

    遠山 慎吾, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(8)　586-586　2017/08

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  599. 小児移植におけるtransitional(移行期)ケアのあり方 小児肝移植後成人移行症例における精神的問題を含めた諸問題

    中西 史, 宮城 重人, 戸子台 和哲, 原 康之, 中西 渉, 齋藤 尚子, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　267-267　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  600. 灌流臓器保存の現状と将来 心停止下摘出肝グラフトに対する酸素化灌流の臓器保存効果

    柿崎 裕太, 宮城 重人, 清水 健司, 米田 海, 熊田 博之, 松村 宗幸, 宮崎 勇希, 福岡 健吾, 植松 智海, 原 康之, 中西 史, 海野 倫明, 亀井 尚, 後藤 昌史

    移植　52　(総会臨時)　282-282　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  601. 膵臓移植:マージナルドナーの適応と限界 当院におけるマージナルドナー膵腎移植の現状

    宮城 重人, 中西 史, 原 康之, 戸子台 和哲, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　293-293　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  602. 当科肝移植患者におけるPTLDの検討

    宮城 重人, 中西 史, 原 康之, 戸子台 和哲, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　352-352　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  603. miRNAによる膵全摘自家膵島移植に対する新規予後予測バイオマーカーの探索

    吉松 軍平, 坂田 直昭, 西中村 瞳, 松岡 泰祐, 高橋 宏幸, Naziruddin Bashoo, 海野 倫明, 小玉 正太

    移植　52　(総会臨時)　402-402　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  604. 血管誘導効果を有するRGD基(Arg-Gly-Asp)含有コラーゲン素材を使用した皮下膵島移植法の樹立

    植松 智海, 稲垣 明子, 中村 保宏, 後藤 めぐみ, 猪村 武弘, 五十嵐 康宏, 亀井 尚, 海野 倫明, 里見 進, 後藤 昌史

    移植　52　(総会臨時)　404-404　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  605. 生体肝移植後腎機能と長期予後ついての検討

    中西 史, 宮城 重人, 戸子台 和哲, 原 康之, 中西 渉, 宮澤 恒持, 清水 健司, 植松 智海, 後藤 昌史, 海野 倫明, 亀井 尚

    移植　52　(総会臨時)　514-514　2017/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  606. 医学教育におけるVisual Analog Scaleの新しい利用方法の提案

    壹岐 裕子, 工藤 克昌, 野田 雅史, 井本 博文, 松田 安史, 伊藤 拓哉, 海野 倫明

    日本シミュレーション医療教育学会雑誌　5　138-138　2017/08

    Publisher: 日本シミュレーション医療教育学会

    ISSN： 2187-9281

  607. Dissection procedures of pancreatic head in the pancreatoduodenectomy for advanced pancreatic cancer

    72　(7)　849-855　2017/07

    Publisher: 医学書院

    ISSN： 0386-9857

  608. Metachronous Multicentric Pancreatic Cancer With Multiple Intraductal Papillary Mucinous Neoplasms (IPMN)

    Mitsuhiro Shimura, Masamichi Mizuma, Takaho Okada, Munetoshi Katagiri, Naoaki Sakata, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Takeshi Naitoh, Shinichi Egawa, Fumiyoshi Fujishima, Atsushi Kanno, Morihisa Hirota, Atsushi Masamune, Tooru Shimosegawa, Michiaki Unno

    PANCREAS　46　(6)　834-834　2017/07

    ISSN： 0885-3177

    eISSN： 1536-4828

  609. 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究 マウス肝障害モデルを用いたMuse細胞移植療法の検討

    伊関 雅裕, 若尾 昌平, 串田 良祐, 水間 正道, 深瀬 正彦, 林 洋毅, 元井 冬彦, 出澤 真理, 海野 倫明

    日本消化器外科学会総会　72回　WS14-11　2017/07

    Publisher: (一社)日本消化器外科学会

  610. エンハンサーRunx1+24mCNEによるマウス胃体部幹細胞の同定および新規前癌病変マウスモデルの解析

    木村 俊一, 松尾 純一, 山村 明寛, 向田 和明, 児山 香, 小川 仁, 海野 倫明, 大里 元美, 伊藤 嘉明, 柴田 近

    日本消化器外科学会総会　72回　RS1-4　2017/07

    Publisher: (一社)日本消化器外科学会

  611. 非機能性膵神経内分泌腫瘍における至適リンパ節郭清に関する検討

    青木 豪, 石田 晶玄, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本消化器外科学会総会　72回　PK3-4　2017/07

    Publisher: (一社)日本消化器外科学会

  612. CGRP静脈投与による結腸運動亢進・排便誘発効果の検討

    小野 智之, 長尾 宗紀, 河野 えみ子, 土屋 堯裕, 井本 博文, 渡辺 和宏, 田中 直樹, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　RS1-16　2017/07

    Publisher: (一社)日本消化器外科学会

  613. 胆道ドレナージが門脈塞栓後代償性肝肥大に与える影響

    深瀬 耕二, 伊関 雅裕, 高舘 達之, 益田 邦洋, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PN2-3　2017/07

    Publisher: (一社)日本消化器外科学会

  614. 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究 LC-MS/MS蛋白質絶対定量法による膵癌Gemcitabine感受性解析と、その臨床応用への可能性 前向き観察研究

    大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 立川 正憲, 寺崎 哲也, 海野 倫明

    日本消化器外科学会総会　72回　O2-84　2017/07

    Publisher: (一社)日本消化器外科学会

  615. 胆管細胞癌に対する治療戦略 肝門部領域のMF型およびMF+PI型肝内胆管癌と肝門部胆管癌との治療成績の比較

    益田 邦洋, 中川 圭, 深瀬 耕二, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　O2-97　2017/07

    Publisher: (一社)日本消化器外科学会

  616. 切除不能膵癌に対するconversion surgeryの位置づけ 切除不能膵癌に対する当科のAdjuvant Surgeryの現状 GEM/S-1時代からGEM-nab-PTX、FOLFIRINOX時代へ

    林 洋毅, 水間 正道, 前田 晋平, 有明 恭平, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本消化器外科学会総会　72回　WS10-9　2017/07

    Publisher: (一社)日本消化器外科学会

  617. 腹腔鏡下胆道手術の要点と盲点 未来に向けて 術後肝内結石発生から見た先天性胆管拡張症に対する腹腔鏡下手術の適応と胆道再建術の手技の要点

    内藤 剛, 森川 孝則, 大塚 英郎, 石田 晶玄, 高舘 達之, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 海野 倫明

    日本消化器外科学会総会　72回　WS08-5　2017/07

    Publisher: (一社)日本消化器外科学会

  618. 腹腔鏡下胆道手術の要点と盲点 未来に向けて 先天性胆管拡張症に対する腹腔鏡下肝外胆管切除・肝管空腸吻合術

    森川 孝則, 大塚 英郎, 石田 晶玄, 高舘 達之, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　WS08-7　2017/07

    Publisher: (一社)日本消化器外科学会

  619. 膵切除後膵液瘻の予防と対策 膵瘻の危険因子から考える至適吻合法

    中川 圭, 元井 冬彦, 深瀬 耕二, 水間 正道, 益田 邦洋, 大塚 英郎, 林 洋毅, 森川 孝則, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　O3-125　2017/07

    Publisher: (一社)日本消化器外科学会

  620. 胃上部癌に対する腹腔鏡下手術の郭清・再建手技の定型化 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除術の治療成績

    武者 宏昭, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　O2-74　2017/07

    Publisher: (一社)日本消化器外科学会

  621. 幽門側胃切除後の膵外分泌機能と栄養状態への影響

    杉沢 徳彦, 工藤 克昌, 武者 宏昭, 田中 直樹, 井本 博文, 青木 豪, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　RS3-128　2017/07

    Publisher: (一社)日本消化器外科学会

  622. クローン病に対する新吻合法(anti-mesenteric cutback end-to-side isoperistaltic anastomosis:東北大法)

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　RS1-31　2017/07

    Publisher: (一社)日本消化器外科学会

  623. 胃巨大GISTに対する術前化学療法の有効性

    唐澤 秀明, 井本 博文, 青木 豪, 工藤 克昌, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　RS1-48　2017/07

    Publisher: (一社)日本消化器外科学会

  624. Stage II大腸癌の治療成績および再発危険因子の検討

    平嶋 倫亮, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PF4-3　2017/07

    Publisher: (一社)日本消化器外科学会

  625. Stage IV大腸癌の外科治療戦略

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 工藤 克昌, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PC6-3　2017/07

    Publisher: (一社)日本消化器外科学会

  626. 外科的切除を施した小腸腫瘍の22例の検討

    小久保 翔志, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PD7-3　2017/07

    Publisher: (一社)日本消化器外科学会

  627. 人工肛門造設患者の術後在院日数短縮に向けた取り組み

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 井本 博文, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　RS2-60　2017/07

    Publisher: (一社)日本消化器外科学会

  628. 腹腔鏡下大腸切除術後に発症したイレウス症例の検討

    青木 泰孝, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 青木 豪, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PF12-3　2017/07

    Publisher: (一社)日本消化器外科学会

  629. 進行胃癌に対する腹腔鏡下胃切除術の安全性と有効性の検討

    田中 直樹, 武者 宏昭, 井本 博文, 青木 豪, 工藤 克昌, 唐澤 秀明, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　72回　PI15-5　2017/07

    Publisher: (一社)日本消化器外科学会

  630. 切除可能膵癌(切除企図膵癌)に対する外科的治療法 (特集 膵疾患の診断と治療) -- (膵癌)

    元井 冬彦, 海野 倫明

    消化器の臨床　20　(3)　200-206　2017/06

    Publisher: ヴァンメディカル

    ISSN： 1344-3070

  631. 成人生体肝移植後晩期合併症である生活習慣病と栄養療法の必要性

    原 康之, 清水 健司, 宮澤 恒持, 中西 渉, 戸子台 和哲, 中西 史, 宮城 重人, 海野 倫明, 亀井 尚

    日本肥満症治療学会学術集会プログラム・抄録集　35回　112-112　2017/06

    Publisher: 日本肥満症治療学会

  632. 肥満症に対する効果的な食事指導法とリバンド対策 減量手術後も主食と間食を減らせば順調に痩せるのか? 減量手術後の食事摂取重量から考える効果的な栄養指導

    岡本 智子, 稲村 なお子, 武田 みゆき, 田中 直樹, 井本 博文, 澤田 正二郎, 片桐 秀樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　48-48　2017/06

    Publisher: 日本肥満症治療学会

  633. Metabolic Surgery 減量外科からmetabolic surgeryへ わが国における現状と課題

    井本 博文, 内藤 剛, 田中 直樹, 長尾 宗紀, 土屋 堯裕, 河野 えみ子, 澤田 正二郎, 片桐 秀樹, 武田 みゆき, 岡本 智子, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　57-57　2017/06

    Publisher: 日本肥満症治療学会

  634. 減量手術後は体重が減るだけでよい?術後早期栄養指導のピットフォール 減量の質向上の手がかりとしての体重減少良好群・不良群の栄養摂取の特徴を考える

    稲村 なお子, 岡本 智子, 武田 みゆき, 田中 直樹, 井本 博文, 澤田 正二郎, 片桐 秀樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　70-70　2017/06

    Publisher: 日本肥満症治療学会

  635. 【潰瘍性大腸炎・クローン病手術のすべて】 クローン病 クローン病に関する疾患概念の変遷と手術の歴史

    舟山 裕士, 鈴木 秀幸, 高橋 賢一, 羽根田 祥, 渡辺 和宏, 海野 倫明

    手術　71　(7)　1005-1010　2017/06

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  636. 【潰瘍性大腸炎・クローン病手術のすべて】 クローン病 クローン病に対する新たな吻合法 Anti-mesenteric cutback end-to-side isoperistaltic anastomosis(東北大法)

    渡辺 和宏, 内藤 剛, 海野 倫明

    手術　71　(7)　1069-1075　2017/06

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  637. 腹腔鏡下スリーブバイパス術後に血清鉄、亜鉛は低下する

    伊勢 一郎, 田中 直樹, 河野 えみ子, 土屋 堯裕, 井本 博文, 渡辺 和宏, 長尾 宗紀, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　141-141　2017/06

    Publisher: 日本肥満症治療学会

  638. 十二指腸空腸バイパス術後のエネルギー代謝におけるbiliopancreatic limbの役割

    河野 えみ子, 長尾 宗紀, 上野 知尭, 伊勢 一郎, 土屋 堯裕, 井本 博文, 田中 直樹, 武者 宏昭, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　104-104　2017/06

    Publisher: 日本肥満症治療学会

  639. 臍ヘルニアを合併した病的肥満患者に対し腹腔鏡下袖状胃切除術とヘルニア単純閉鎖術を併施した一例

    上野 知尭, 井本 博文, 田中 直樹, 長尾 宗紀, 武者 宏昭, 土屋 堯裕, 工藤 克昌, 青木 豪, 阿部 友哉, 大沼 忍, 渡辺 和宏, 唐澤 秀明, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35回　150-150　2017/06

    Publisher: 日本肥満症治療学会

  640. 【胆膵腫瘍に対する術前治療と切除前後の効果判定法】 肝外胆管癌に対する術前治療と効果判定法

    中川 圭, 片寄 友, 深瀬 耕二, 益田 邦洋, 高舘 達之, 伊関 雅裕, 元井 冬彦, 海野 倫明

    胆と膵　38　(5)　453-458　2017/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  641. 膵癌の早期診断・治療の現状と展望 膵癌登録における2cm以下(TS1)膵癌の解析

    水間 正道, 海野 倫明, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 濱田 晋, 水元 一博, 岡崎 和一, 日本膵臓学会膵癌登録委員会

    膵臓　32　(3)　321-321　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  642. 動物を用いた若手医師の外科手術トレーニングと動物倫理

    壹岐 裕子, 野田 雅史, 工藤 克昌, 末田 輝子, 兼平 雅彦, 伊藤 拓哉, 松田 安史, 岡田 克典, 海野 倫明

    胸部外科　70　(5)　329-333　2017/05

    Publisher: (株)南江堂

    ISSN： 0021-5252

  643. 膵NETの診療ガイドラインの問題点と今後の展望 外科治療の観点から診療ガイドラインを考える 至適術式・リンパ節郭清範囲

    青木 豪, 石田 晶玄, 伊関 雅裕, 前田 晋平, 有明 恭平, 高舘 達之, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　32　(3)　311-311　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  644. 膵癌取扱い規約第7版によるBorderline resectable膵癌の特徴と治療戦略 BR膵癌に対する術前治療戦略

    元井 冬彦, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　32　(3)　367-367　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  645. IPMNの手術適応と術式を再考する IPMN手術症例におけるリンパ節郭清の適応について

    石田 晶玄, 元井 冬彦, 前田 晋平, 有明 恭平, 青木 豪, 深瀬 耕二, 坂田 直昭, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    膵臓　32　(3)　393-393　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  646. 腹水細胞診陽性膵癌は切除すべきか? FOLFIRINOX、GEM-nab-PTX時代の治療戦略

    林 洋毅, 有明 恭平, 水間 正道, 前田 晋平, 高舘 達之, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    膵臓　32　(3)　471-471　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  647. 膵癌切除後症例に対するCD-DST法を用いた感受性試験の現状と問題点

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 前田 晋平, 高舘 達之, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 森川 孝則, 中川 圭, 坂田 直昭, 石田 晶玄, 内藤 剛, 海野 倫明

    膵臓　32　(3)　505-505　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  648. 当科における術後膵瘻の再検討 ISGPS2016の改訂を受けて

    森川 孝則, 元井 冬彦, 水間 正道, 伊関 雅裕, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　32　(3)　522-522　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  649. 男性に発生した粘液性嚢胞性腫瘍(MCN)の1例

    高舘 達之, 水間 正道, 伊関 雅裕, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 菅野 敦, 下瀬川 徹, 海野 倫明

    膵臓　32　(3)　634-634　2017/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  650. 【漢方薬を導入した臨床栄養の新しい展開】 幽門側胃切除術後クリニカルパスへの六君子湯の導入の効果

    工藤 克昌, 武者 宏昭, 田中 直樹, 青木 豪, 井本 博文, 杉沢 徳彦, 内藤 剛, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(2)　951-954　2017/05

    Publisher: (株)ジェフコーポレーション

    DOI： 10.11244/jspen.32.951 　

    ISSN： 2189-0161

    eISSN： 2189-017X

  651. 家族性大腸腺腫症52例の治療成績

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 小野 智之, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(5)　350-350　2017/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  652. Stage II/III結腸癌における腹腔鏡手術と開腹手術の検討

    小野 智之, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(5)　379-379　2017/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  653. NEW RECONSTRUCTIVE PROCEDURE AFTER INTESTINAL RESECTION FOR CROHN'S DISEASE: ANTIMESENTERIC CUTBACK END-TO-SIDE ISOPERISTALTIC ANASTOMOSIS

    Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Shinobu Ohnuma, Hideaki Karasawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    GASTROENTEROLOGY　152　(5)　S1285-S1286　2017/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  654. 【診断と治療のABC[121]胆石症・胆管結石 胆道炎・胆道がん】 (第1章)胆石症 肝内結石症の診断・治療

    有明 恭平, 大塚 英郎, 海野 倫明

    最新医学　別冊　(胆石症・胆管結石・胆道炎・胆道がん)　55-64　2017/04

    Publisher: (株)最新医学社

    ISSN： 0370-8241

  655. 消化器系癌患者における苦味受容体TAS2Rの遺伝子型解析

    八巻 美智子, 齋藤 弘貴, 磯野 邦夫, 後藤 知子, 白川 仁, 庄司 憲明, 佐藤 しづ子, 笹野 高嗣, 岡田 良, 工藤 克昌, 元井 冬彦, 海野 倫明, 駒井 三千夫

    日本栄養・食糧学会大会講演要旨集　71回　336-336　2017/04

    Publisher: (公社)日本栄養・食糧学会

  656. 膵癌登録における膵癌リンパ節転移個数の予後解析 膵癌取扱い規約改訂におけるビッグデータ利活用

    水間 正道, 海野 倫明, 伊佐地 秀司, 五十嵐 久人, 糸井 隆夫, 江川 新一, 児玉 裕三, 里井 壯平, 濱田 晋, 水元 一博, 岸和田 昌之, 北川 裕久, 高折 恭一, 谷 眞至, 羽鳥 隆, 藤井 努, 村上 義昭, 山口 幸二, 吉富 秀幸, 岡崎 和一, 日本膵臓学会膵癌登録委員会

    日本外科学会定期学術集会抄録集　117回　SF-74　2017/04

    Publisher: (一社)日本外科学会

  657. EUS-FNAにより組織採取が可能であった膵漿液性嚢胞腫瘍の3例

    鍋島 立秀, 菅野 敦, 正宗 淳, 本郷 星仁, 吉田 直樹, 中野 絵里子, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 藤島 史喜, 海野 倫明, 下瀬川 徹

    Gastroenterological Endoscopy　59　(Suppl.1)　1108-1108　2017/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  658. 嚢胞切除にて切除しえた巨大膵管内乳頭粘液性腫瘍の1例

    佐藤 正規, 深瀬 耕二, 有明 恭平, 大塚 英郎, 村上 圭吾, 藤島 史喜, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　50　(4)　303-310　2017/04

    Publisher: (一社)日本消化器外科学会

    DOI： 10.5833/jjgs.2016.0147 　

    ISSN： 0386-9768

  659. CGRP投与の結腸運動に対する効果

    小野 智之, 長尾 宗紀, 河野 えみ子, 土屋 堯裕, 井本 博文, 渡辺 和宏, 田中 直樹, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-106　2017/04

    Publisher: (一社)日本外科学会

  660. Precision medicine bench to bedside LC-MS/MS蛋白質絶対定量法をもちいた腫瘍組織中薬物代謝関連蛋白質発現量測定の、周術期ゲムシタビン療法効果予測への応用 前向き臨床試験

    大塚 英郎, 川口 桂, 井上 亨悦, 四條 正浩, 有明 恭平, 高舘 達之, 前田 晋平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 立川 正憲, 寺崎 哲也, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　SY-7　2017/04

    Publisher: (一社)日本外科学会

  661. 肝門部胆管癌手術のコツとピットフォール 肝門部領域胆管癌における膵内胆管へのアプローチ

    深瀬 耕二, 中川 圭, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　SY-10　2017/04

    Publisher: (一社)日本外科学会

  662. 肝門部胆管癌手術のコツとピットフォール 肝門部胆管癌動脈合併切除症例における動脈再建のコツとピットフォール ジャンプグラフトを含めた安全な再建法の工夫

    宮城 重人, 宮澤 恒持, 清水 健司, 中西 渉, 中川 圭, 林 洋毅, 原 康之, 戸子台 和哲, 中西 史, 海野 倫明, 大内 憲明

    日本外科学会定期学術集会抄録集　117回　SY-10　2017/04

    Publisher: (一社)日本外科学会

  663. 肝再生を考慮した肝切除 基礎から臨床へ 多層的オミックス解析による門脈塞栓後代償性肝肥大の分子メカニズムの解明

    佐藤 好宏, 大塚 英郎, 深瀬 耕二, 加藤 恭丈, 松本 光代, 蝦名 真行, 有明 恭平, 益田 邦洋, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　WS-2　2017/04

    Publisher: (一社)日本外科学会

  664. Borderline resectable膵癌に対する集学的治療 Borderline resectable膵癌に対する治療前PET SUVmax値を用いた層別化 術前治療の適応

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　WS-10　2017/04

    Publisher: (一社)日本外科学会

  665. 肝内胆管癌の局在および多様性から見た術式選択 肝門部領域のMF型およびMF+PI型肝内胆管癌の治療成績

    益田 邦洋, 中川 圭, 深瀬 耕二, 高舘 達之, 前田 晋平, 有明 恭平, 青木 豪, 石田 晶玄, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　WS-19　2017/04

    Publisher: (一社)日本外科学会

  666. 開腹下経回結腸静脈門脈経路による門脈ステント留置術

    前田 晋平, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-050　2017/04

    Publisher: (一社)日本外科学会

  667. 当科の混合型IPMN切除例の後方視的検討

    高舘 達之, 森川 孝則, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-139　2017/04

    Publisher: (一社)日本外科学会

  668. 膵切除例における偶発的膵神経内分泌腫瘍併発例の検討

    初沢 悠人, 水間 正道, 志村 充広, 高舘 達之, 阿部 友哉, 有明 恭平, 前田 晋平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-218　2017/04

    Publisher: (一社)日本外科学会

  669. 慢性膵炎に対するFrey手術は栄養状態を改善する

    佐藤 英昭, 坂田 直昭, 青木 豪, 石田 晶玄, 工藤 克昌, 大沼 忍, 深瀬 耕二, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-219　2017/04

    Publisher: (一社)日本外科学会

  670. 膵癌術前治療後の低骨格筋量は予後不良因子である

    志村 充広, 水間 正道, 阿部 友哉, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-224　2017/04

    Publisher: (一社)日本外科学会

  671. 安全性および医療倫理に留意した胆膵内視鏡外科手術

    森川 孝則, 石田 晶玄, 高館 達之, 大塚 英郎, 青木 豪, 有明 恭平, 前田 晋平, 益田 邦洋, 大沼 忍, 田中 直樹, 深瀬 耕二, 阿部 友哉, 水間 正道, 坂田 直昭, 武者 宏昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　SF-42　2017/04

    Publisher: (一社)日本外科学会

  672. 十二指腸空腸バイパスにおけるbiliopancreatic limbがエネルギー代謝に及ぼす影響の検討

    河野 えみ子, 長尾 宗紀, 土屋 尭裕, 井本 博文, 渡辺 和宏, 田中 直樹, 大沼 忍, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　SF-47　2017/04

    Publisher: (一社)日本外科学会

  673. 重度の全身疾患を有する症例の胃癌手術成績

    杉沢 徳彦, 武者 宏昭, 田中 直樹, 工藤 克昌, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-085　2017/04

    Publisher: (一社)日本外科学会

  674. Stage4大腸癌における治療成績と再分類

    小野 智之, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(4)　254-254　2017/04

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  675. 直腸癌術前化学放射線療法効果判定におけるPET-CTの意義

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(4)　266-266　2017/04

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  676. 括約筋間直腸切除術の治療成績

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(4)　288-288　2017/04

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  677. 外科領域における漢方の役割 胃切除術後に対する六君子湯の術式による効果の違い

    工藤 克昌, 武者 宏昭, 田中 直樹, 杉沢 徳彦, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 唐澤 秀明, 井本 博文, 土屋 堯裕, 水間 正道, 坂田 直昭, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　WS-11　2017/04

    Publisher: (一社)日本外科学会

  678. 大腸外科で求められる会陰再建法

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　SF-35　2017/04

    Publisher: (一社)日本外科学会

  679. 当科における胃GISTに対する腹腔鏡下手術の治療成績及び治療戦略

    井本 博文, 唐澤 秀明, 杉沢 徳彦, 青木 豪, 工藤 克昌, 田中 直樹, 大沼 忍, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-003　2017/04

    Publisher: (一社)日本外科学会

  680. 遠隔転移を有する大腸癌に対する外科治療戦略

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-029　2017/04

    Publisher: (一社)日本外科学会

  681. コーチング理論を用いた技術の言語化による腹腔鏡下直腸切除術の指導

    内藤 剛, 大沼 忍, 阿部 友哉, 唐澤 秀明, 渡辺 和宏, 長尾 宗紀, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 土屋 堯裕, 武者 宏昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-080　2017/04

    Publisher: (一社)日本外科学会

  682. 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除術の手技および治療成績

    武者 宏昭, 土屋 堯裕, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-092　2017/04

    Publisher: (一社)日本外科学会

  683. 潰瘍性大腸炎術後に発症した小腸出血症例の検討

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 土屋 堯裕, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-185　2017/04

    Publisher: (一社)日本外科学会

  684. クローン病に対する新しい腸管吻合法(antimesenteric cutback end-to-end anastomosis:東北大法)の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 土屋 堯裕, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　117回　PS-186　2017/04

    Publisher: (一社)日本外科学会

  685. Evidence-based clinical practice guidelines for cholelithiasis 2016

    Susumu Tazuma, Michiaki Unno, Yoshinori Igarashi, Kazuo Inui, Kazuhisa Uchiyama, Masahiro Kai, Toshio Tsuyuguchi, Hiroyuki Maguchi, Toshiyuki Mori, Koji Yamaguchi, Shomei Ryozawa, Yuji Nimura, Naotaka Fujita, Keiichi Kubota, Junichi Shoda, Masami Tabata, Tetsuya Mine, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa

    JOURNAL OF GASTROENTEROLOGY　52　(3)　276-300　2017/03

    DOI： 10.1007/s00535-016-1289-7 　

    ISSN： 0944-1174

    eISSN： 1435-5922

  686. 当院における膵粘液性嚢胞腫瘍(MCN)症例の検討

    鍋島 立秀, 菅野 敦, 正宗 淳, 本郷 星仁, 吉田 直樹, 中野 絵里子, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 元井 冬彦, 海野 倫明, 藤島 史喜, 下瀬川 徹

    日本消化器病学会雑誌　114　(臨増総会)　A283-A283　2017/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  687. 胃幹細胞の同定(Identification of stem/progenitor cells in the stomach corpus and antrum)

    山村 明寛, 松尾 純一, 木村 俊一, Zaini Dede Liana, Mon Naing Naing, Hossain Md Zakir, 海野 倫明, So Jimmy Bok Yan, Meng Teh, Yeoh Khay Guan, 大里 元美, 伊藤 嘉明

    日本胃癌学会総会記事　89回　251-251　2017/03

    Publisher: (一社)日本胃癌学会

  688. IBDの腸管合併症および腸管外合併症のマネージメントと工夫 内科・外科治療の接点 潰瘍性大腸炎術後に発症した小腸出血症例の検討

    長尾 宗紀, 渡辺 和宏, 海野 倫明

    日本消化器病学会雑誌　114　(臨増総会)　A92-A92　2017/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  689. 栄養面から考えたFrey手術の至適時期の検証

    佐藤 英昭, 坂田 直昭, 青木 豪, 石田 晶玄, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　114　(臨増総会)　A261-A261　2017/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  690. がん抑制遺伝子PHLDA3の膵島移植における特性

    坂田 直昭, 大木 理恵子, 佐藤 英昭, 吉松 軍平, 青木 豪, 石田 晶玄, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明, 角 昭一郎

    日本消化器病学会雑誌　114　(臨増総会)　A282-A282　2017/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  691. 胃癌術後の膵外分泌機能と栄養状態の関連(The association between exocrine function of the pancreas and nutritional status after gastrectomy)

    杉沢 徳彦, 武者 宏昭, 田中 直樹, 工藤 克昌, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　89回　239-239　2017/03

    Publisher: (一社)日本胃癌学会

  692. 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除の手技と治療成績(Outcome & procedure of LAPG reconstruction after valvuloplastic esophagogastrostomy)

    武者 宏昭, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　89回　269-269　2017/03

    Publisher: (一社)日本胃癌学会

  693. 胃癌内視鏡治療後の追加外科治療症例の検討(Clinicopathological features of cases of additional surgery after endoscopic treatment)

    田中 直樹, 武者 宏昭, 工藤 克昌, 杉沢 徳彦, 土屋 堯裕, 井本 博文, 青木 豪, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　89回　373-373　2017/03

    Publisher: (一社)日本胃癌学会

  694. 胃全摘術後における六君子湯の効果(The effect of Rikkun-shito after total gastrectomy)

    工藤 克昌, 武者 宏昭, 田中 直樹, 杉沢 徳彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　89回　425-425　2017/03

    Publisher: (一社)日本胃癌学会

  695. 高度リンパ節転移を伴う切除不能胆嚢癌にgemcitabine/cisplatin療法と手術切除による集学的治療を施行した1例

    竹浪 努, 中川 圭, 橘 知睦, 藪内 伸一, 唐澤 秀明, 片寄 友, 元井 冬彦, 内藤 剛, 藤島 史喜, 海野 倫明

    日本消化器外科学会雑誌　50　(3)　222-230　2017/03

    Publisher: (一社)日本消化器外科学会

    DOI： 10.5833/jjgs.2016.0038 　

    ISSN： 0386-9768

  696. クローン病症例における手術回数ごとの手術率の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 工藤 克昌, 青木 豪, 井本 博文, 土屋 堯裕, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　114　(臨増総会)　A300-A300　2017/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  697. 急性膵炎モデルマウスの作成とその定量評価法の確立 抗サイトカイン療法の実現へ向けての基礎実験

    深瀬 正彦, 坂田 直昭, 川口 桂, 若尾 昌平, 串田 良祐, 出澤 真理, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　222-222　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  698. がん抑制遺伝子PHLDA3を標的とする膵島移植法確立のための基盤研究

    坂田直昭, 大木理恵子, 佐藤英昭, 吉松軍平, 吉松軍平, 青木豪, 石田晶玄, 元井冬彦, 内藤剛, 海野倫明, 角昭一郎

    日本膵・膵島移植研究会プログラム・抄録集　44th　84　2017/02

  699. 膵島移植における新規ドナーの開発に向けて:がん抑制遺伝子PHLDA3をターゲットとした治療戦略

    坂田直昭, 大木理恵子, 佐藤英昭, 吉松軍平, 青木豪, 石田晶玄, 元井冬彦, 内藤剛, 海野倫明, 角昭一郎

    再生医療　16　327　2017/02/01

    ISSN： 1347-7919

  700. 敗血症・院内感染にいかに挑むか 長期予後から検討した待機的肝胆膵手術における敗血症の意義

    片寄 友, 武藤 満完, 伊勢 一郎, 林 洋毅, 中川 圭, 森川 孝則, 水間 正道, 大塚 英郎, 高橋 賢一, 西條 文人, 松村 直樹, 野村 良平, 安本 明浩, 羽根田 祥, 徳村 弘実, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　241-241　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  701. 当科で経験した外傷性膵損傷症例の検討

    伊関 雅裕, 前田 晋平, 高舘 達之, 深瀬 耕二, 工藤 克昌, 大塚 英郎, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　275-276　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  702. 人工肛門部が原因となった術後腸閉塞症の検討

    工藤 克昌, 前田 晋平, 伊関 雅裕, 大沼 忍, 武者 宏昭, 阿部 友哉, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 青木 豪, 唐澤 秀明, 井本 博文, 土屋 堯裕, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　274-275　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  703. 高気圧酸素療法が有効であった門脈ガス血症を呈した急性腸炎の一例

    相澤 卓, 工藤 克昌, 前田 晋平, 土屋 尭裕, 井本 博文, 唐澤 秀明, 青木 豪, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　343-343　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  704. 抗TNF-α抗体による加療後における潰瘍性大腸炎緊急手術の手術成績

    廣澤 貴志, 工藤 克昌, 前田 晋平, 井本 博文, 唐澤 秀明, 青木 豪, 大沼 忍, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(2)　345-345　2017/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  705. 当科における大腸癌同時性肺転移治療の現状

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(2)　128-128　2017/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  706. 大腸癌同時性肝転移の治療方針

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 小林 実, 井本 博文, 有明 恭平, 青木 豪, 工藤 克昌, 石田 晶玄, 佐々木 宏之, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　70　(2)　134-134　2017/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  707. 移植前肝細胞に対するADP/ATP ratioを用いた新規評価法の確立

    松村宗幸, 猪村武弘, 小笠原弘之, 福岡健吾, 稲垣明子, 宮城重人, 大橋一夫, 海野倫明, 亀井尚, 里見進, 後藤昌史, 後藤昌史

    移植(Web)　52　(6)　2017

    ISSN： 2188-0034

  708. EUS-FNAにより組織採取が可能であった膵漿液性嚢胞腫瘍の3例

    鍋島立秀, 菅野敦, 正宗淳, 本郷星仁, 吉田直樹, 中野絵里子, 三浦晋, 濱田晋, 粂潔, 菊田和宏, 廣田衛久, 藤島史喜, 海野倫明, 下瀬川徹

    Gastroenterological Endoscopy (Web)　59　(Supplement1)　2017

    ISSN： 1884-5738

  709. Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer (vol 139, pg 2493, 2016)

    Yayoi Takahashi, Tamotsu Sugai, Wataru Habano, Kazuyuki Ishida, Makoto Eizuka, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Takanori Morikawa, Michiaki Unno, Hiromu Suzuki

    INTERNATIONAL JOURNAL OF CANCER　140　(1)　E1-E1　2017/01

    DOI： 10.1002/ijc.30466 　

    ISSN： 0020-7136

    eISSN： 1097-0215

  710. National Clinical Database(消化器外科領域)Annual Report 2015

    掛地吉弘, 宇田川晴司, 海野倫明, 遠藤格, 國崎主税, 武冨紹信, 丹黒章, 正木忠彦, 丸橋繁, 吉田和弘, 渡邉聡明, 後藤満一, 今野弘之, 高橋新, 宮田裕章, 宮田裕章, 瀬戸泰之

    日本消化器外科学会雑誌(Web)　50　(2)　166‐176(J‐STAGE)　2017

    DOI： 10.5833/jjgs.2017.sr001 　

    ISSN： 1348-9372

  711. 膵全摘術症例における体組成変化の評価 CT法とインピーダンス法の比較

    志村 充広, 元井 冬彦, 有明 恭平, 前田 晋平, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　396-396　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  712. 膵癌膵全摘例での術後アルブミン値回復に対する膵酵素補充療法の効果

    元井 冬彦, 有明 恭平, 石田 晶玄, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　421-421　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  713. 胃全摘術後六君子湯の食事摂取・栄養状態に対する効果

    工藤 克昌, 大沼 忍, 石田 晶玄, 井本 博文, 小原 恵, 長尾 宗紀, 渡辺 和宏, 有明 恭平, 志村 充広, 水間 正道, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　434-434　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  714. 慢性膵炎の栄養状態に外科治療が及ぼす影響の検討

    佐藤 英昭, 石田 晶玄, 盛 彬子, 志村 充広, 井本 博文, 有明 恭平, 工藤 克昌, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 水間 正道, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　470-470　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  715. 在宅中心静脈栄養症例のポートカテーテル感染に対する抗菌剤/抗真菌剤併用ロック療法の有用性の検討(続報)

    渡辺 和宏, 長尾 宗紀, 工藤 克昌, 大沼 忍, 井本 博文, 前田 晋平, 有明 恭平, 石田 晶玄, 水間 正道, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　527-527　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  716. 腹腔鏡所見により結核性腹膜炎を早期に診断できた1例

    石橋 令臣, 大島 謙吾, 遠藤 史郎, 大江 千紘, 馬場 啓聡, 藤川 祐子, 猪股 真也, 曽木 美佐, 吉田 真紀子, 具 芳明, 賀来 満夫, 井本 博文, 田中 直樹, 海野 倫明

    結核　92　(1)　52-52　2017/01

    Publisher: (一社)日本結核病学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  717. 膵癌におけるPETSUVmaxは遠隔転移再発の予測因子となる

    有明恭平, 元井冬彦, 前田晋平, 大塚英郎, 深瀬耕二, 益田邦弘, 高館達之, 石田晶玄, 水間正道, 坂田直昭, 中川圭, 森川孝則, 林洋毅, 下村英雄, 寺尾千秋, 舘脇康子, 江川新一, 内藤剛, 海野倫明

    日本外科学会定期学術集会(Web)　117th　ROMBUNNO.PS‐217‐4 (WEB ONLY)　2017

  718. BMI 60kg/m2以上の超重症高度肥満症に対するチームアプローチでの術前減量

    田中直樹, 内藤剛, 井本博文, 土屋堯裕, 長尾宗紀, 武田みゆき, 岡本智子, 澤田正二郎, 片桐秀樹, 新國悦弘, 鈴木文歌, 上月正博, 元井冬彦, 海野倫明

    日本肥満症治療学会学術集会プログラム・抄録集　35th　60　2017

  719. RGD基を含有する新規コラーゲン素材のリコンビナントペプチド(RCP)を用いた皮下膵島移植の試み

    植松智海, 稲垣明子, 中村保宏, 後藤めぐみ, 猪村武弘, 猪村梢, 五十嵐康宏, 亀井尚, 海野倫明, 里見進, 後藤昌史, 後藤昌史

    移植(Web)　52　(6)　565(J‐STAGE)　2017

    ISSN： 2188-0034

  720. 経皮的ドレナージと経腸栄養による保存的治療で改善した十二指腸瘻の2例

    佐藤 純, 工藤 克昌, 前田 晋平, 唐澤 秀明, 田中 直樹, 青木 豪, 大沼 忍, 武者 宏昭, 川崎 修平, 小野 智之, 廣澤 貴志, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　37　(1)　69-74　2017/01

    Publisher: (一社)日本腹部救急医学会

    DOI： 10.11231/jaem.37.069 　

    ISSN： 1340-2242

  721. 外来患者の栄養補助・支援を目的とした「栄養支援ステーション」の開設 実践報告

    前田 晋平, 菅野 直子, 奥山 祐, 岡本 智子, 稲村 なお子, 元井 冬彦, 香取 幸夫, 海野 倫明

    日本静脈経腸栄養学会雑誌　32　(Suppl.)　757-757　2017/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  722. Identification of novel biomarkers distinguishing pancreatic head cancer from distal cholangiocarcinoma discovered by proteomics analysis

    T. Takenami, S. Maeda, H. Karasawa, Y. Mochizuki, T. Aizawa, S. Jun, H. Musha, T. Morikawa, K. Nakagawa, H. Hayashi, F. Motoi, T. Naitoh, M. Unno

    ANNALS OF ONCOLOGY　27　2016/12

    ISSN： 0923-7534

    eISSN： 1569-8041

  723. The expression and functional role of Cripto-1 in human colorectal cancer

    S. Jun, H. Karasawa, T. Suzuki, S. Nakayama, M. Katagiri, S. Maeda, S. Ohnuma, F. Motoi, T. Naitoh, M. Unno

    ANNALS OF ONCOLOGY　27　2016/12

    ISSN： 0923-7534

    eISSN： 1569-8041

  724. 進行膵癌に対する審査腹腔鏡の有用性

    高舘 達之, 森川 孝則, 石田 晶玄, 前田 晋平, 有明 恭平, 益田 邦洋, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　OS79-7　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  725. 機能温存腹腔鏡下膵切除術の定型化に向けた取り組み 腹腔鏡下脾温存膵体尾部切除術におけるWarshaw手術の意義

    森川 孝則, 石田 晶玄, 高館 達之, 青木 豪, 深瀬 耕二, 大沼 忍, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　PD3-3　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  726. 腹腔鏡下尾側膵切除における術野展開の工夫 腹腔鏡下脾温存膵尾側切除術における術野展開の工夫

    石田 晶玄, 森川 孝則, 高舘 達之, 有明 恭平, 前田 晋平, 青木 豪, 工藤 克昌, 大沼 忍, 深瀬 耕二, 阿部 友哉, 武者 宏昭, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　WS4-4　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  727. 潰瘍性大腸炎に対する腹腔鏡下手術の治療成績

    阿部 友哉, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 青木 豪, 工藤 克昌, 田中 直樹, 井本 博文, 林 洋毅, 中川 圭, 森川 孝則, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　OS160-6　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  728. 若年性多発胆嚢ポリープの1例

    吉町 信吾, 井本 博文, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐沢 秀明, 土屋 堯裕, 内藤 剛, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　DP101-8　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  729. 肥満・糖尿病に対する内視鏡下手術の現状と展望 超重症肥満・重症糖尿病に対するバイパス手術への取り組み

    田中 直樹, 内藤 剛, 井本 博文, 土屋 堯裕, 武者 宏昭, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 森川 孝則, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　WS22-7　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  730. 内視鏡外科手術の教育 コーチング理論を用いた技術の言語化による直腸切除術の指導法

    内藤 剛, 大沼 忍, 阿部 友哉, 唐澤 秀明, 渡辺 和宏, 長尾 宗紀, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　WS24-6　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  731. スリーブ状胃切除術の手技とピットフォール 当科における腹腔鏡下スリーブ状胃切除術の手術手技

    井本 博文, 内藤 剛, 田中 直樹, 武者 宏昭, 工藤 克昌, 青木 豪, 土屋 堯裕, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 河野 えみ子, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　RS3-2　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  732. 多数回開腹手術例(Difficult Abdomen)に対する腹腔鏡下手術 How I Do it? 腹部手術既往を有する症例に対する腹腔鏡下大腸切除術

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　RS12-1　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  733. 早期胃癌に対する噴門側胃切除術のメリットとデメリット 逆流防止弁形成食道残胃吻合を用いた腹腔鏡補助下噴門側胃切除術の利点と欠点

    武者 宏昭, 土屋 堯裕, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　RS41-5　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  734. 胃GISTに対するLECS症例の検討

    青木 豪, 武者 宏昭, 土屋 堯裕, 井本 博文, 唐澤 秀明, 工藤 克昌, 大沼 忍, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　OS39-2　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  735. 当科におけるクローン病に対する腹腔鏡下手術の周術期成績についての検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 田中 直樹, 工藤 克昌, 青木 豪, 井本 博文, 土屋 堯裕, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　OS161-2　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  736. 腹腔鏡下大腸切除後イレウス発症の予測因子について

    青木 泰孝, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 田中 直樹, 工藤 克昌, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　DP49-10　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  737. 高齢者大腸癌(75歳以上)に対する腹腔鏡下大腸切除術

    平嶋 倫亮, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　21　(7)　DP50-1　2016/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  738. Clinical features of anorectal cancer in Crohn's disease: Japanese single center study

    Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Shinobu Ohnuma, Hideaki Karasawa, Hiroaki Musha, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　31　175-175　2016/11

    ISSN： 0815-9319

    eISSN： 1440-1746

  739. Long-term experience with intestinal Behcet's disease after surgery

    Ichiro Ise, Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Hideaki Karasawa, Shinobu Ohnuma, Hiroaki Musha, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　31　177-177　2016/11

    ISSN： 0815-9319

    eISSN： 1440-1746

  740. 【IPMNとIPNB】 IPMNに対する腹腔鏡下膵切除術

    森川 孝則, 石田 晶玄, 高舘 達之, 元井 冬彦, 内藤 剛, 海野 倫明

    外科　78　(11)　1186-1191　2016/11

    Publisher: (株)南江堂

    DOI： 10.15106/J00393.2017032236 　

    ISSN： 0016-593X

  741. イマチニブによる術前化学療法が奏効した胃巨大GISTの1切除例

    佐藤 好宏, 唐澤 秀明, 青木 豪, 井本 博文, 田中 直樹, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 大沼 忍, 武者 宏昭, 高橋 雅信, 元井 冬彦, 内藤 剛, 石岡 千加史, 海野 倫明

    癌と化学療法　43　(12)　2216-2218　2016/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  742. 化学療法が奏効しConversion Therapyを施行した切除不能進行直腸癌の1例

    佐藤 純, 唐澤 秀明, 前田 晋平, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    癌と化学療法　43　(12)　2145-2147　2016/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  743. イマチニブによる術前化学療法が奏効した胃巨大GISTの1切除例

    佐藤 好宏, 唐澤 秀明, 青木 豪, 井本 博文, 田中 直樹, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 大沼 忍, 武者 宏昭, 高橋 雅信, 元井 冬彦, 内藤 剛, 石岡 千加史, 海野 倫明

    癌と化学療法　43　(12)　2216-2218　2016/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  744. パクリタキセル+カルボプラチン療法が奏効したS状結腸未分化癌の1例

    遠山 慎吾, 工藤 克昌, 大沼 忍, 佐藤 聡子, 田中 直樹, 青木 豪, 井本 博文, 唐澤 秀明, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    癌と化学療法　43　(12)　2295-2297　2016/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  745. BACKGROUND OF MAJOR HEPATO-BILIARY-PANCREATIC SURGERY-INDUCED SEPSIS

    Yu Katayose, Ichiro Ise, Hiroki Hayashi, Mitsuhisa Mutoh, Kei Nakagawa, Takanori Morikawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    SHOCK　46　(4)　25-26　2016/10

    ISSN： 1073-2322

    eISSN： 1540-0514

  746. Runx1エンハンサーは胃体部および幽門部において胃幹細胞をマークする

    山村 明寛, 松尾 純一, 木村 俊一, Zakir Hossain Md, 河府 和義, 日合 弘, 海野 倫明, Bok Yan So Jimmy, The Meng, Guan Yeoh Khay, 大里 元美, 伊藤 嘉明

    日本癌学会総会記事　75回　E-3070　2016/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  747. 術前化学療法、放射線療法と術後感染 膵胆道癌術前治療は膵頭十二指腸切除術の手術部位感染を増加させるか?

    水間 正道, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本外科感染症学会雑誌　13　(5)　467-467　2016/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  748. 膵癌・胆管癌術後SSI発生予測における血流依存性血管拡張反応(FMD)検査の後方視的検討

    高舘 達之, 水間 正道, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科感染症学会雑誌　13　(5)　548-548　2016/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  749. 切除不能から可能へ Conversion Therapy(肝・胆・膵) Initially unresectable pancreatic cancerに対するadjuvant surgeryの意義

    林 洋毅, 水間 正道, 前田 晋平, 有明 恭平, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　353-353　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  750. 肝膵同時切除の適応と手技の工夫 広範囲胆管癌の胆管断端ステータスと切除成績

    益田 邦洋, 中川 圭, 深瀬 耕二, 高舘 達之, 前田 晋平, 有明 恭平, 石田 昌玄, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　356-356　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  751. 内視鏡下手術でのトラブル 次の一手!(肝・胆・膵) 腹腔鏡下膵体尾部切除術のpitfallとrecovery shot

    森川 孝則, 石田 昌玄, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　371-371　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  752. Borderline Resectable膵癌に対する治療成績と展望 borderline resectable膵癌に対する術前治療と腫瘍マーカー陰性化の意義

    水間 正道, 元井 冬彦, 林 洋毅, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　391-391　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  753. 膵体尾部切除における膵断端処理の工夫 当科における腹腔鏡下膵体尾部切除術の術後膵瘻の予防法

    石田 晶玄, 森川 孝則, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　406-406　2016/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.77.406 　

    ISSN： 1345-2843

  754. 術後肝予備能維持にむけたBest Practice アシアロシンチを用いた門脈塞栓術後の肝予備能の検討

    佐藤 正規, 深瀬 耕二, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　416-416　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  755. 当科における膵粘液性嚢胞腫瘍切除例の後方視的検討

    高舘 達之, 森川 孝則, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　765-765　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  756. 切除不能膵癌に対するGemcitabine+Nab-Paclitaxel(GN)療法を用いた集学的治療 Planned Adjuvant Surgeryの試み

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　767-767　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  757. 慢性膵炎に対するFrey手術が術後の栄養状態に及ぼす効果の検討

    佐藤 英昭, 坂田 直昭, 青木 豪, 石田 晶玄, 工藤 克昌, 大沼 忍, 深瀬 耕二, 大塚 英郎, 水間 正道, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　790-790　2016/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.77.790 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  758. 巨大肝粘液性嚢胞腺癌(MCN)の一切除例

    初沢 悠人, 中川 圭, 水間 正道, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　954-954　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  759. 膵臓 進行膵がんに対するアプローチ 画像診断陰性の転移(M1)膵癌切除例の予後因子 術前・術中因子による切除適応の再検討

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　MS15-3　2016/10

    Publisher: (一社)日本癌治療学会

  760. 胆道 胆道がんに対する集学的治療 胆管癌切除例に対するgemcitabine補助化学療法の検討

    中川 圭, 深瀬 耕二, 益田 邦洋, 高舘 達之, 前田 晋平, 有明 恭平, 石田 晶玄, 水間 正道, 坂田 直昭, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　MS32-2　2016/10

    Publisher: (一社)日本癌治療学会

  761. 膵臓 膵がん手術療法の多様な視点 膵腫瘍切除患者の術前から6ヵ月までのQuality of lifeの評価

    佐藤 菜保子, 元井 冬彦, 有明 恭平, 川口 桂, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 宮武 ミドリ, 片寄 友, 佐藤 冨美子, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　MS41-5　2016/10

    Publisher: (一社)日本癌治療学会

  762. 膵臓 膵がん治療の個別化に向けて 膵癌企途切症例に対する薬剤感受性試験(CD-DST法)から見た抗癌剤治療の有用性について

    有明 恭平, 元井 冬彦, 水間 正道, 前田 晋平, 高館 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS1-2　2016/10

    Publisher: (一社)日本癌治療学会

  763. 膵臓 膵がんに対する化学療法の新展開 切除不能膵癌一次治療におけるnab-paclitaxel+gemcitabineの治療成績

    前田 晋平, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS3-2　2016/10

    Publisher: (一社)日本癌治療学会

  764. 膵臓 外科切除における検討 膵癌術前治療の効果判定におけるPETの有用性

    水間 正道, 有明 恭平, 前田 晋平, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS76-3　2016/10

    Publisher: (一社)日本癌治療学会

  765. 直腸癌骨盤内再発に対する治療戦略 直腸癌局所再発に対する骨盤内臓全摘術

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　365-365　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  766. 炎症性腸疾患のBest Practice クローン病に対する新しい腸管吻合法(anti-mesenteric cutback end-to-end anastomosis 東北大法)の中期成績の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 土屋 堯裕, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　428-428　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  767. 10mm以下の直腸神経内分泌腫瘍における手術適応

    阿部 友哉, 青木 豪, 坂田 直昭, 橘 知睦, 唐澤 秀明, 大沼 忍, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　482-482　2016/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.77.482 　

    ISSN： 1345-2843

  768. 当科における高齢者大腸癌(75歳以上)の短期手術成績

    四條 正浩, 唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏明, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　515-515　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  769. 逆流防止弁形成食道残胃吻合再建を用いた腹腔鏡補助下噴門側胃切除術の治療成績

    武者 宏昭, 土屋 堯裕, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　533-533　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  770. 当科における高齢大腸癌患者に対する術後補助化学療法の現状

    望月 保志, 唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏明, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　584-584　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  771. 胃に発生したCystic Dystrophy in Heterotopic Pancreas(CDHP)の1例

    小野 智之, 工藤 克昌, 武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 大沼 忍, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 藤島 史喜, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　647-647　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  772. 大腸癌に対する骨盤内臓器合併切除の治療成績

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　77　(増刊)　729-729　2016/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  773. BAP1発現変化による肝内胆管癌への影響

    石居 健太郎, 大沼 忍, 小林 実, 高館 達之, 前田 晋平, 有明 恭平, 唐澤 秀明, 大塚 英郎, 水間 正道, 林 洋毅, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本癌学会総会記事　75回　J-1022　2016/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  774. Cripto-1はヒト大腸癌において重要な予後因子となり得る

    佐藤 純, 唐澤 秀明, 鈴木 貴, 中山 瞬, 片桐 宗利, 前田 晋平, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌学会総会記事　75回　J-2026　2016/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  775. 大腸 直腸がん手術療法の多様な視点 括約筋間直腸切除術(ISR)の治療成績

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS28-1　2016/10

    Publisher: (一社)日本癌治療学会

  776. 大腸 直腸がん手術療法の多様な視点 Stage 0/I直腸癌に対する腹腔鏡下手術

    小野 智之, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS28-5　2016/10

    Publisher: (一社)日本癌治療学会

  777. 胃 併発合併症 重度の全身疾患を有する胃癌手術症例の治療成績

    杉沢 徳彦, 武者 宏昭, 田中 直樹, 工藤 克昌, 井本 博文, 唐澤 秀明, 青木 豪, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　WS29-3　2016/10

    Publisher: (一社)日本癌治療学会

  778. 肛門管扁平上皮癌に対する治療戦略

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会学術集会抄録集　54回　P10-11　2016/10

    Publisher: (一社)日本癌治療学会

  779. 腸管運動障害の診断と治療 慢性偽性腸閉塞症(CIPO)に対する外科治療

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 大沼 忍, 唐澤 秀明, 工藤 克昌, 柴田 近, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A37-A37　2016/10

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  780. 遺伝性大腸がん、ポリポーシスに対する治療戦略 当科における家族性大腸腺腫症の治療成績

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A45-A45　2016/10

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  781. StageII大腸癌における再発リスクファクターの検討

    平嶋 倫亮, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A64-A64　2016/10

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  782. 腸閉塞治療としての高気圧酸素療法

    小野 智之, 大沼 忍, 工藤 克昌, 土屋 堯裕, 井本 博文, 唐澤 秀明, 青木 豪, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A102-A102　2016/10

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  783. Stage IV大腸癌の治療戦略

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 土屋 堯裕, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A140-A140　2016/10

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  784. 血清CEA値による癌スクリーニングはクローン病の直腸肛門部癌の診断・予後に有用である可能性がある

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 工藤 克昌, 前田 晋平, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　69　(抄録号)　A157-A157　2016/10

    Publisher: (一社)日本大腸肛門病学会

    DOI： 10.3862/jcoloproctology.69.A157 　

    ISSN： 0047-1801

  785. 腹腔内出血を伴う外傷性膵・十二指腸損傷に対してIVRを先行し一期的に膵頭十二指腸切除を施行した1例

    遠山 慎吾, 前田 晋平, 有明 恭平, 益田 邦洋, 工藤 克昌, 深瀬 耕二, 林 洋毅, 元井 冬彦, 内藤 剛, 高瀬 圭, 海野 倫明

    Japanese Journal of Acute Care Surgery　6　(2)　219-219　2016/09

    Publisher: 日本Acute Care Surgery学会

  786. 【膵癌分子診断研究の最前線:リキッドバイオプシーから次世代DNAシークエンシングまで】 プロテオミクス解析を応用した膵癌分子診断研究の現状

    高舘 達之, 前田 晋平, 元井 冬彦, 海野 倫明

    胆と膵　37　(9)　819-823　2016/09

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  787. 【内分泌代謝疾患のtrends & topics 2017】 代謝 肥満症に対する外科治療の現状と展望

    内藤 剛, 田中 直樹, 井本 博文, 海野 倫明

    Mebio　33　(9)　57-63　2016/09

    Publisher: (株)メジカルビュー社

    ISSN： 0910-0474

  788. IIIb型外傷性膵損傷に対して腹腔鏡補助下膵体尾部切除を施行した1例

    前田 晋平, 高舘 達之, 工藤 克昌, 菅野 敦, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 下瀬川 徹, 海野 倫明

    Japanese Journal of Acute Care Surgery　6　(2)　219-219　2016/09

    Publisher: 日本Acute Care Surgery学会

  789. 三次元組織体による血管化膵島の作成とその機能

    坂田 直昭, 松崎 典弥, 吉松 軍平, 西口 昭広, 佐藤 英昭, 廣澤 貴志, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 明石 満, 海野 倫明

    移植　51　(総会臨時)　324-324　2016/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  790. 肥満外科治療の最前線 重症肥満症例に対するスリーブバイパス術の減量・代謝改善効果とその機序

    内藤 剛, 田中 直樹, 井本 博文, 土屋 堯裕, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 海野 倫明

    肥満研究　22　(Suppl.)　152-152　2016/09

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  791. 膵胆管合流異常に対する腹腔鏡下肝外胆管切除術 開腹術、腹腔鏡下およびロボット手術の比較

    森川 孝則, 大塚 英郎, 石田 昌玄, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　39　44-44　2016/08

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  792. 細胞積層法による血管化膵島の開発

    坂田 直昭, 松崎 典弥, 吉松 軍平, 西口 昭広, 青木 豪, 石田 晶玄, 元井 冬彦, 内藤 剛, 片寄 友, 明石 満, 海野 倫明

    移植　51　(2-3)　293-293　2016/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  793. 胆道癌術後合併症発生予測における血流依存性血管拡張反応(FMD)検査の有用性の後方視的検討

    高舘 達之, 水間 正道, 前田 晋平, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　30　(3)　498-498　2016/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  794. 抗凝固薬内服中に出血を来した胆嚢腺筋腫症の1例

    吉町 信吾, 高舘 達之, 水間 正道, 有明 恭平, 深瀬 耕二, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　30　(3)　569-569　2016/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  795. 膵頭十二指腸切除術術後に発症した肝内結石症の検討

    大塚 英郎, 有明 恭平, 高舘 達之, 青木 豪, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    胆道　30　(3)　619-619　2016/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  796. 膵全摘術+自家膵島移植症例の経過について

    坂田 直昭, 元井 冬彦, 澤田 正二郎, 林 洋毅, 水間 正道, 深瀬 耕二, 五十嵐 康宏, 中川 圭, 内藤 剛, 後藤 昌史, 海野 倫明

    移植　51　(2-3)　304-304　2016/08

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  797. 【肥満手術が代謝に及ぼす影響】 糖尿病合併重症肥満患者に対するスリーブバイパス術の効果

    内藤 剛, 田中 直樹, 宮地 智洋, 井本 博文, 土屋 堯裕, 河野 えみ子, 長尾 宗紀, 武者 宏昭, 中川 圭, 森川 孝則, 元井 冬彦, 片寄 友, 海野 倫明

    外科と代謝・栄養　50　(4)　217-222　2016/08

    Publisher: 日本外科代謝栄養学会

    DOI： 10.11638/jssmn.50.4_217 　

    ISSN： 0389-5564

  798. Treatment of postoperative bile leakage after liver resection

    71　(7)　816-820　2016/07

    Publisher: 医学書院

    ISSN： 0386-9857

  799. 門脈結紮後代償性肝肥大における細胞周期関連遺伝子の発現制御機構と、転写因子FOXM1の機能解析

    佐藤 好宏, 大塚 英郎, 深瀬 耕二, 加藤 恭丈, 松本 光代, 元井 冬彦, 内藤 剛, 江川 新一, 五十嵐 和彦, 海野 倫明

    日本消化器外科学会総会　71回　P1-3　2016/07

    Publisher: (一社)日本消化器外科学会

  800. 術中操作がもたらす膵癌腹膜播種再発の危険性 予防を目指した臨床研究への取り組み

    有明 恭平, 元井 冬彦, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 水間 正道, 林 洋毅, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会総会　71回　P1-3　2016/07

    Publisher: (一社)日本消化器外科学会

  801. 腸内環境と肥満症・糖尿病治療 Metabolic surgeryと腸内環境

    土屋 堯裕, 宮地 智洋, 井本 博文, 田中 直樹, 長尾 宗紀, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　43-43　2016/07

    Publisher: 日本肥満症治療学会

  802. 減量手術後の食事回数、摂取栄養量と減量効果の関連

    武田 みゆき, 岡本 智子, 稲村 なお子, 田中 直樹, 井本 博文, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　66-66　2016/07

    Publisher: 日本肥満症治療学会

  803. 膵島移植における血管新生の重要性と血管化膵島に対する期待

    坂田 直昭, 松崎 典弥, 吉松 軍平, 西口 昭広, 青木 豪, 石田 晶玄, 元井 冬彦, 内藤 剛, 明石 満, 海野 倫明

    日本消化器外科学会総会　71回　P2-67　2016/07

    Publisher: (一社)日本消化器外科学会

  804. 十二指腸空腸バイパスにおけるbilio-pancreatic limbの機能 食餌誘発性肥満ラットでの検討

    河野 えみ子, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 井本 博文, 宮地 智洋, 土屋 堯裕, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　94-94　2016/07

    Publisher: 日本肥満症治療学会

  805. 門脈塞栓後代償性肝肥大予測因子の検討

    深瀬 耕二, 高舘 達之, 益田 邦洋, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-59　2016/07

    Publisher: (一社)日本消化器外科学会

  806. 進行胆嚢癌の外科治療成績から見た手術適応と治療戦略

    益田 邦洋, 林 洋毅, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-61　2016/07

    Publisher: (一社)日本消化器外科学会

  807. 膵癌術前治療における体組織変化と予後との関係

    志村 充広, 水間 正道, 阿部 友哉, 高舘 達之, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-67　2016/07

    Publisher: (一社)日本消化器外科学会

  808. 切除不能局所進行膵癌に対するadjuvant surgeryの効果

    林 洋毅, 前田 晋平, 坂田 直昭, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本消化器外科学会総会　71回　P1-73　2016/07

    Publisher: (一社)日本消化器外科学会

  809. 腹腔鏡下肝胆膵手術の最近の改良点と問題点 Orthodox & Serendipity 腹腔鏡式膵臓-胆管手術の将来展望(Recent refinement and problem of laparoscopic hepato-biliary-pancreatic surgery: Orthodox & Serendipity Future perspective of laparoscopic pancreato-biliary surgery)

    森川 孝則, 石田 昌玄, 高舘 達之, 青木 豪, 大塚 英郎, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　SY8-8　2016/07

    Publisher: (一社)日本消化器外科学会

  810. 残膵癌に対し残膵全摘術を施行した15例の検討

    高舘 達之, 水間 正道, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会総会　71回　P2-74　2016/07

    Publisher: (一社)日本消化器外科学会

  811. 膵癌におけるPET-SUVmaxと病理学的因子の検討

    前田 晋平, 水間 正道, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 元井 冬彦, 江川 新一, 海野 倫明

    日本消化器外科学会総会　71回　P2-75　2016/07

    Publisher: (一社)日本消化器外科学会

  812. 切除企図膵癌における治癒切除困難性の推定

    元井 冬彦, 前田 晋平, 大塚 英郎, 水間 正道, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器外科学会総会　71回　P2-75　2016/07

    Publisher: (一社)日本消化器外科学会

  813. 膵・胆道癌術後転移再発に対する外科的切除の役割

    水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 江川 新一, 岡田 克典, 海野 倫明

    日本消化器外科学会総会　71回　P3-61　2016/07

    Publisher: (一社)日本消化器外科学会

  814. 膵インスリノーマ35症例の検討 肝転移をきたす症例の特徴

    青木 豪, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P3-66　2016/07

    Publisher: (一社)日本消化器外科学会

  815. LSG施行後5年目にrevision surgeryとして再LSG/DJBを施行した糖尿病合併重症肥満の1例

    伊勢 一郎, 田中 直樹, 河野 えみ子, 土屋 堯裕, 井本 博文, 渡辺 和宏, 長尾 宗紀, 武者 宏昭, 澤田 正二郎, 片桐 秀樹, 岡本 智子, 武田 みゆき, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　75-75　2016/07

    Publisher: 日本肥満症治療学会

  816. 術前減量を考慮して腹腔鏡下スリーブ状胃切除術の治療効果を検討する

    田中 直樹, 内藤 剛, 伊勢 一郎, 河野 えみ子, 土屋 堯裕, 井本 博文, 渡辺 和宏, 長尾 宗紀, 武者 宏昭, 澤田 正二郎, 片桐 秀樹, 武田 みゆき, 岡本 智子, 元井 冬彦, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　77-77　2016/07

    Publisher: 日本肥満症治療学会

  817. 当院における減量手術の治療成績の検討

    井本 博文, 田中 直樹, 武者 宏昭, 土屋 堯裕, 河野 えみ子, 澤田 正二郎, 片桐 秀樹, 岡本 智子, 武田 みゆき, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　34回　78-78　2016/07

    Publisher: 日本肥満症治療学会

  818. 若手外科医育成のための工夫 東北大学病院先端医療技術トレーニングセンターにおける消化器外科手術トレーニングの運用と課題

    工藤 克昌, 井本 博文, 水間 正道, 田中 直樹, 長尾 宗紀, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　WS1-2　2016/07

    Publisher: (一社)日本消化器外科学会

  819. 低体重は胃切除術の合併症リスク因子である

    田中 直樹, 武者 宏昭, 工藤 克昌, 青木 豪, 井本 博文, 杉沢 徳彦, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-21　2016/07

    Publisher: (一社)日本消化器外科学会

  820. 腹腔鏡下膵尾側切除術におけるリスクマネージメント その予防と対処のポイント

    石田 晶玄, 森川 孝則, 青木 豪, 坂田 直昭, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-55　2016/07

    Publisher: (一社)日本消化器外科学会

  821. 重度の全身疾患を有する胃癌手術症例の検討

    杉沢 徳彦, 武者 宏昭, 田中 直樹, 工藤 克昌, 大沼 忍, 長尾 宗紀, 阿部 友哉, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P2-19　2016/07

    Publisher: (一社)日本消化器外科学会

  822. 代謝手術の次の段階 Orthodox & Serendipity 日本における代謝手術としてsleeve bypassは必要なのか(Next stage of metabolic surgery: Orthodox & Serendipity Is Sleeve Bypass necessary as a metabolic surgery in Japan?)

    内藤 剛, 田中 直樹, 井本 博文, 長尾 宗紀, 渡辺 和宏, 阿部 友哉, 大沼 忍, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本消化器外科学会総会　71回　SY6-5　2016/07

    Publisher: (一社)日本消化器外科学会

  823. 腹腔鏡補助下噴門側胃切除術(逆流防止弁形成食道残胃吻合)の手技および治療成績

    武者 宏昭, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　VD9-8　2016/07

    Publisher: (一社)日本消化器外科学会

  824. 当科における残胃癌に対する外科治療と手術成績に関する検討

    井本 博文, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 大沼 忍, 阿部 友哉, 長尾 宗紀, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P3-15　2016/07

    Publisher: (一社)日本消化器外科学会

  825. 10mm以下の直腸神経内分泌腫瘍(NET)におけるリンパ節転移の危険性

    阿部 友哉, 青木 豪, 大沼 忍, 唐澤 秀明, 長尾 宗紀, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-27　2016/07

    Publisher: (一社)日本消化器外科学会

  826. 術後排便機能・QOL・医療費からみた潰瘍性大腸炎に対する外科治療の役割

    渡辺 和宏, 長尾 宗紀, 大沼 忍, 阿部 友哉, 唐澤 秀明, 工藤 克昌, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P1-42　2016/07

    Publisher: (一社)日本消化器外科学会

  827. 他臓器浸潤を伴う進行大腸癌の治療戦略 骨盤内臓器合併切除を施行した原発性大腸癌の治療成績

    唐澤 秀明, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　WS17-5　2016/07

    Publisher: (一社)日本消化器外科学会

  828. 当科における腸管型ベーチェット病症例の特徴および術後長期予後の検討

    伊勢 一郎, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P3-44　2016/07

    Publisher: (一社)日本消化器外科学会

  829. がん性消化管閉塞に対する緩和手術の意義 安全性と予後評価

    小原 恵, 大沼 忍, 工藤 克昌, 石田 晶玄, 唐澤 秀明, 渡辺 和宏, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　71回　P3-80　2016/07

    Publisher: (一社)日本消化器外科学会

  830. 先天性胆管拡張症に対する腹腔鏡下肝外胆管切除術 腹腔鏡下およびロボット手術の経験

    森川 孝則, 内藤 剛, 石田 昌玄, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 元井 冬彦, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　405-405　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  831. Conversion surgery for patients with unresectable pancreato-biliary cancer 腹膜転移膵癌に対するS1+パクリタキセル経静脈・腹腔内併用療法とコンバージョン手術 PII多施設共同試験(Conversion surgery for patients with unresectable pancreato-biliary cancer Conversion surgery in pancreatic ductal adenocarcino

    倉田 昌直, 里井 壯平, 藤井 努, 柳本 泰明, 元井 冬彦, 高原 楠昊, 山田 豪, 山本 智久, 水間 正道, 本田 五郎, 伊佐山 浩通, 海野 倫明, 小寺 康弘, 石神 浩徳, 權 雅憲, 膵癌腹膜転移治療研究会

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　367-367　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  832. Surgical approach for HBP surgery; Major vessel resection and reconstruction in HBP surgery 肝門部領域胆管癌に対する血管合併切除の手術手技と治療成績(Surgical approach for HBP surgery: Major vessel resection and reconstruction in HBP surgery Surgical technique and outcome of major ve

    深瀬 耕二, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　341-341　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  833. 膵癌術後の腹膜播種に対する対策について リスク因子から見た検討(How to prevent the peritoneal recurrence: considering the risk factor of peritoneal recurrence after pancreatectomy)

    有明 恭平, 元井 冬彦, 大塚 英郎, 深瀬 耕二, 益田 邦弘, 水間 正道, 林 洋毅, 前田 晋平, 高舘 達之, 内藤 剛, 森川 孝則, 中川 圭, 石田 晶玄, 坂田 直昭, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　392-392　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  834. 血流依存性血管拡張反応(FMD)検査と膵頭十二指腸切除術周術期合併症の検討(Usefulness of flow mediated dilation(FMD) test for prediction of postoperative complications in pancreatoduodenectomy)

    高舘 達之, 水間 正道, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　394-394　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  835. 安全な腹腔鏡下膵切除術のための工夫と対策

    石田 晶玄, 森川 孝則, 石居 健太郎, 谷口 肇, 深瀬 正彦, 佐藤 好宏, 青木 修一, 高舘 達之, 前田 晋平, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　453-453　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  836. 膵頭十二指腸切除術後周術期血糖管理標準化の試み

    大塚 英郎, 元井 冬彦, 有明 恭平, 前田 晋平, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　459-459　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  837. 膵癌大動脈周囲リンパ節転移陽性例の切除成績

    水間 正道, 元井 冬彦, 有明 恭平, 高舘 達之, 前田 晋平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　499-499　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  838. 膵癌術前治療における骨格筋量と予後に関する検討

    志村 充広, 水間 正道, 高舘 達之, 有明 恭平, 前田 晋平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　499-499　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  839. 膵全摘76例の手術成績と長期予後

    前田 晋平, 水間 正道, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　509-509　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  840. 腫瘤形成型肝内胆管癌に対する胆管切除を伴うリンパ節郭清

    益田 邦洋, 中川 圭, 前田 晋平, 高舘 達之, 有明 恭平, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　581-581　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  841. Conversion surgery for patients with unresectable pancreato-biliary cancer BR-A膵癌に対するAdjuvant surgeryおよび術後CA19-9陰性化の意義(Conversion surgery for patients with unresectable pancreato-biliary cancer The impact of the adjuvant surgery and the normalization of p

    林 洋毅, 佐藤 好宏, 青木 修一, 前田 晋平, 高舘 達之, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 森川 孝則, 内藤 剛, 元井 冬彦, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　367-367　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  842. 広範囲胆管癌に対する肝膵同時切除

    中川 圭, 深瀬 耕二, 益田 邦洋, 高館 達之, 青木 修一, 谷口 肇, 石居 健太郎, 前田 晋平, 有明 恭平, 青木 豪, 石田 晶玄, 水間 正道, 大塚 英郎, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　28回　425-425　2016/06

    Publisher: (一社)日本肝胆膵外科学会

  843. 新しい栄養剤の研究・臨床効果 六君子湯の腹腔鏡下幽門側胃切除術後に対する効果

    工藤 克昌, 武者 宏昭, 田中 直樹, 杉沢 徳彦, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 井本 博文, 唐澤 秀明, 元井 冬彦, 内藤 剛, 海野 倫明

    外科と代謝・栄養　50　(3)　157-157　2016/06

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  844. 【肝胆膵がん治療2016】 膵癌切除の進歩と補助療法

    元井 冬彦, 水間, 正道, 林, 洋毅, 海野 倫明

    Mebio　33　(5)　48-55　2016/05

  845. 泌尿器科手術のチーム力アップに何が必要か より良いストーマ作成のためのチーム力

    高橋 真紀, 長尾 宗紀, 三塚 浩二, 生澤 史江, 伊藤 由美, 海野 倫明

    日本泌尿器科学会総会　104回　PPS04-5　2016/04

    Publisher: (一社)日本泌尿器科学会総会事務局

  846. 肝外胆管癌治療における至適術式選択 切除例の解析からみた肝外胆管癌の治療戦略

    中川 圭, 深瀬 耕二, 益田 邦洋, 岡田 良, 前田 晋平, 有明 恭平, 川口 桂, 青木 豪, 石田 晶玄, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　SY-1　2016/04

    Publisher: (一社)日本外科学会

  847. 転移性肺腫瘍の外科治療 up to date 膵胆道癌術後肺転移に対する切除意義

    水間 正道, 前田 晋平, 有明 恭平, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 野田 雅史, 桜田 晃, 星川 康, 岡田 克典, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PD-5　2016/04

    Publisher: (一社)日本外科学会

  848. 膵頭部癌に対する動脈先行処理・亜全胃温存膵頭十二指腸切除

    林 洋毅, 元井 冬彦, 水間 正道, 森川 孝則, 中川 圭, 大塚 英郎, 坂田 直昭, 深瀬 耕二, 石田 晶玄, 益田 邦洋, 川口 桂, 岡田 良, 有明 恭平, 前田 晋平, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-007　2016/04

    Publisher: (一社)日本外科学会

  849. 膵癌切除後肝転移再発症例における臨床病理学的因子の検討

    有明 恭平, 元井 冬彦, 大塚 英郎, 前田 晋平, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-073　2016/04

    Publisher: (一社)日本外科学会

  850. 肝門部胆管癌の画像診断の新展開 術式選択の根拠と課題 肝門部胆管癌治療成績から検討した術前診断の現状と課題

    深瀬 耕二, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 岡田 良, 石田 晶玄, 水間 正道, 坂田 直昭, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　SY-13　2016/04

    Publisher: (一社)日本外科学会

  851. 局所進行膵癌に対する集学的治療 主要動脈接触を伴う局所進行膵癌に対する集学的治療 企図された補助切除を目指して

    元井 冬彦, 前田 晋平, 有明 恭平, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 昌玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　WS-13　2016/04

    Publisher: (一社)日本外科学会

  852. 門脈結紮後の代償性肝肥大における、FOXM1による細胞周期関連遺伝子の活性化の意義

    佐藤 好宏, 大塚 英郎, 加藤 恭丈, 松本 光代, 蝦名 真行, 前田 晋平, 有明 恭平, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 五十嵐 和彦, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-180　2016/04

    Publisher: (一社)日本外科学会

  853. 主膵管狭窄を来し、ductulo-insular typeの組織像を呈したセロトニン産生の膵神経内分泌腫瘍

    橘 知睦, 笠島 敦子, 青木 豪, 坂田 直昭, 海野 倫明, 笹野 公伸

    日本病理学会会誌　105　(1)　442-442　2016/04

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  854. 肥満糖尿病の病態解明と治療法の開発 病態と臓器障害・合併症の観点から 十二指腸-空腸バイパスを伴うスリーブ状胃切除術の抗糖尿病効果とその作用機序(New mechanisms and treatments for obese type 2 diabetes: from the aspects of pathophysiology, organ damages, and complications Anti-diabetic effect and its mechanisms of the sleeve g

    内藤 剛, 田中 直樹, 井本 博文, 土屋 堯裕, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 海野 倫明

    糖尿病　59　(Suppl.1)　S-101　2016/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  855. 肝内胆管癌におけるBAP1変異の影響

    石居 健太郎, 石田 晶玄, 工藤 克昌, 大沼 忍, 田中 直樹, 長尾 宗紀, 阿部 友哉, 水間 正道, 大塚 英郎, 坂田 直昭, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-003　2016/04

    Publisher: (一社)日本外科学会

  856. 重症急性膵炎の治療戦略 急性膵炎に対する手術の変遷と今後の展望

    石田 晶玄, 元井 冬彦, 有明 恭平, 前田 晋平, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 工藤 克昌, 大沼 忍, 深瀬 耕二, 阿部 友哉, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　SY-7　2016/04

    Publisher: (一社)日本外科学会

  857. 成人期に至った先天性疾患治療の現状と課題 手術時年齢からの先天性胆道拡張症術後長期合併症の検討

    大塚 英郎, 森川 孝則, 有明 恭平, 深瀬 耕二, 益田 邦洋, 川口 桂, 前田 晋平, 石田 晶玄, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 元井 冬彦, 大沼 忍, 武者 宏昭, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　SY-12　2016/04

    Publisher: (一社)日本外科学会

  858. 転移を有する膵神経内分泌腫瘍の臨床病理学的性質

    青木 豪, 大塚 英朗, 大沼 忍, 阿部 友哉, 水間 正道, 坂田 直昭, 武者 宏昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-163　2016/04

    Publisher: (一社)日本外科学会

  859. Duodenal jejunal bypassのNASH改善効果の検証

    土屋 堯裕, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 井本 博文, 大沼 忍, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-092　2016/04

    Publisher: (一社)日本外科学会

  860. 中心静脈カテーテル管理における安全対策 在宅中心静脈栄養管理症例のカテーテル管理の問題点、およびカテーテル感染に対する抗菌剤/抗真菌剤併用ロック療法の有用性の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 工藤 克昌, 武者 宏昭, 大沼 忍, 田中 直樹, 青木 豪, 唐澤 秀明, 井本 博文, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　WS-6　2016/04

    Publisher: (一社)日本外科学会

  861. 潰瘍性大腸炎治療における鏡視下手術の有用性

    阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 大沼 忍, 林 洋毅, 武者 宏昭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-062　2016/04

    Publisher: (一社)日本外科学会

  862. 当科におけるタクロリムス不応潰瘍性大腸炎手術症例の検討

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 唐澤 秀明, 大沼 忍, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-062　2016/04

    Publisher: (一社)日本外科学会

  863. 進行胃癌に対する腹腔鏡下胃切除術の治療成績

    武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 長尾 宗紀, 田中 直樹, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-122　2016/04

    Publisher: (一社)日本外科学会

  864. 切除可能Stage 3、大型3型、4型胃癌に対するS1+weekly CDDP療法による術前化学療法の治療成績

    田中 直樹, 武者 宏昭, 工藤 克昌, 青木 豪, 井本 博文, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-127　2016/04

    Publisher: (一社)日本外科学会

  865. 大腸癌細胞におけるWntシグナルによるABCC3(MRP3)の発現制御

    小林 実, 大沼 忍, 舟山 亮, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 石田 晶玄, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 中山 啓子, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-140　2016/04

    Publisher: (一社)日本外科学会

  866. 重症肥満に対する減量手術における術前VLCD療法の安全性と術後の体組成変化

    内藤 剛, 田中 直樹, 井本 博文, 武者 宏昭, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 工藤 克昌, 佐々木 宏之, 唐澤 秀明, 土屋 堯裕, 河野 えみ子, 元井 冬彦, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-100　2016/04

    Publisher: (一社)日本外科学会

  867. 大腸癌に対する新規バイオマーカー・治療標的 Cripto-1

    唐澤 秀明, 佐藤 純, 中山 瞬, 井本 博文, 青木 豪, 工藤 克昌, 大沼 忍, 渡辺 和宏, 田中 直樹, 阿部 友哉, 長尾 宗紀, 大塚 英郎, 水間 正道, 坂田 直昭, 武者 宏昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-088　2016/04

    Publisher: (一社)日本外科学会

  868. 初期研修医に対する外傷基本手技のウエットラボ習得効果

    工藤 克昌, 野田 雅史, 水間 正道, 井本 博文, 大沼 忍, 石田 晶玄, 田中 直樹, 渡辺 和宏, 青木 豪, 唐澤 秀明, 坂田 直昭, 大塚 英郎, 長尾 宗紀, 阿部 友哉, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　OP-101　2016/04

    Publisher: (一社)日本外科学会

  869. 直腸癌局所再発に対する骨盤内臓全摘術

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 佐々木 宏之, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大塚 英郎, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　116回　PS-224　2016/04

    Publisher: (一社)日本外科学会

  870. チーム医療コーナー 管理栄養士の視点 なぜリバウンドするのか? 自己管理を主体的に行うようになるための医療者の関わりについて考える

    岡本 智子, 稲村 なお子, 武田 みゆき, 梅木 諒, 金子 直美, 澤田 正二郎, 片桐 秀樹, 田中 直樹, 内藤 剛, 海野 倫明

    肥満症治療学展望　(8)　6-6　2016/03

    Publisher: 日本肥満症治療学会

  871. 【イラストでみる最新の胆・膵消化管吻合術】 膵空腸吻合 柿田法

    柿田 徹也, 及川 昌也, 本多 博, 土屋 誉, 元井 冬彦, 内藤 剛, 海野 倫明

    胆と膵　37　(3)　233-236　2016/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  872. 【最新 肝胆膵高難度外科手術アトラス】 高難度外科手術手技 膵臓 膵体尾部切除(D2リンパ節郭清を伴う)

    林 洋毅, 元井, 冬彦, 水間, 正道, 川口, 桂, 前田, 晋平, 海野 倫明

    手術　70　(4)　531-536　2016/03

    DOI： 10.18888/J00620.2016212814 　

  873. 切除膵癌の予後因子としての転移リンパ節個数の意義

    元井 冬彦, 前田 晋平, 有明 恭平, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　113　(臨増総会)　A235-A235　2016/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  874. 高齢者に対する腹腔鏡下(補助下)胃切除術の安全性

    田中 直樹, 武者 宏昭, 工藤 克昌, 佐々木 宏之, 杉沢 徳彦, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 唐澤 秀明, 井本 博文, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　88回　206-206　2016/03

    Publisher: (一社)日本胃癌学会

  875. 胃切除症例における膵外分泌機能の変化

    杉沢 徳彦, 工藤 克昌, 武者 宏昭, 田中 直樹, 佐々木 宏之, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 唐澤 秀明, 井本 博文, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　88回　319-319　2016/03

    Publisher: (一社)日本胃癌学会

  876. 腹腔鏡下幽門側胃切除術後クリニカルパスへの六君子湯の導入の効果

    工藤 克昌, 武者 宏昭, 田中 直樹, 佐々木 宏之, 杉沢 徳彦, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 唐澤 秀明, 井本 博文, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　88回　345-345　2016/03

    Publisher: (一社)日本胃癌学会

  877. 腹腔鏡補助下噴門側胃切除(逆流防止弁形成食道残胃吻合)の手技

    武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　88回　477-477　2016/03

    Publisher: (一社)日本胃癌学会

  878. 潰瘍性大腸炎術後症例の排便状況の検討およびQOLに影響を及ぼす因子の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 井本 博文, 唐澤 秀明, 工藤 克昌, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　113　(臨増総会)　A297-A297　2016/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  879. 慢性偽性腸閉塞症(CIPO)に対する外科治療の位置づけ 当科での手術症例の経験から

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 唐澤 秀明, 大沼 忍, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 柴田 近, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　113　(臨増総会)　A307-A307　2016/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  880. スリーブ胃切除および十二指腸空腸バイパス術の糖尿病改善効果

    内藤 剛, 田中 直樹, 井本 博文, 長尾 宗紀, 渡辺 和宏, 土屋 堯裕, 河野 えみ子, 唐澤 秀明, 青木 豪, 工藤 克昌, 阿部 友哉, 大沼 忍, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本消化器病学会雑誌　113　(臨増総会)　A319-A319　2016/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  881. The ATOM trial: A multicenter, randomized phase II study of modified FOLFOX6 plus bevacizumab and modified FOLFOX6 plus cetuximab for colorectal cancer with liver-limited metastases.

    Yasunori Emi, Kei Muro, Takeharu Yamanaka, Yu Katayose, Hiroyuki Uetake, Kenichi Sugihara, Yoshihiro Kakeji, Michiaki Unno, Ichinosuke Hyodo, Naohiro Tomita, Yoshihiko Maehara

    JOURNAL OF CLINICAL ONCOLOGY　34　(4)　2016/02

    ISSN： 0732-183X

    eISSN： 1527-7755

  882. 経腸栄養療法の併用による保存加療で改善した多発上部消化管穿孔の1例

    佐藤 純, 工藤 克昌, 前田 晋平, 小野 智之, 廣澤 貴志, 川崎 修平, 渡辺 和宏, 田中 直樹, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　36　(2)　402-402　2016/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  883. 改めて腸閉塞を考える 腸閉塞に対する高圧酸素療法の効果

    小野 智之, 工藤 克昌, 廣澤 貴志, 佐藤 純, 川崎 修平, 前田 晋平, 大沼 忍, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　36　(2)　332-332　2016/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  884. 抗血栓薬投与症例に対する腹部救急治療 抗凝固療法中に発症した非外傷性小腸壁内出血の1例

    廣澤 貴志, 工藤 克昌, 小野 智之, 佐藤 純, 川崎 修平, 前田 晋平, 青木 豪, 田中 直樹, 武者 宏昭, 坂田 直昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　36　(2)　355-355　2016/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  885. 当科における腹部救急診療の特徴

    工藤 克昌, 前田 晋平, 廣澤 貴志, 佐藤 順, 川崎 修平, 小野 智之, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 武者 宏昭, 大沼 忍, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　36　(2)　402-402　2016/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  886. 動脈塞栓術にて止血し得た膵仮性嚢胞内出血によるhemosuccus pancreaticusの1例

    相澤 卓, 前田 晋平, 唐澤 秀明, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 菅野 敦, 元井 冬彦, 内藤 剛, 高瀬 圭, 海野 倫明

    日本腹部救急医学会雑誌　36　(2)　478-478　2016/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  887. 膵癌患者の術後栄養状態とQOLの経時的評価

    佐藤 菜保子, 片寄 友, 元井 冬彦, 中川 圭, 坂田 直昭, 川口 桂, 海野 倫明, 佐藤 冨美子

    日本がん看護学会誌　30　(Suppl.)　198-198　2016/01

    Publisher: (一社)日本がん看護学会

    ISSN： 0914-6423

  888. 【新たに定義された"肝門部領域胆管癌"の診断と治療】 外科治療と内科治療 術前術後補助療法

    中川 圭, 片寄 友, 深瀬 耕二, 益田 邦洋, 高舘 達之, 元井 冬彦, 海野 倫明

    胆と膵　37　(1)　95-99　2016/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  889. 【新たに定義された"肝門部領域胆管癌"の診断と治療】 治療方針決定のための診断法 EUS・IDUSを用いた肝門部領域胆管癌の診断

    菅野 敦, 正宗 淳, 三浦 晋, 吉田 直樹, 本郷 星仁, 中野 絵里子, 濱田 晋, 菊田 和宏, 粂 潔, 廣田 衛久, 下瀬川 徹, 深瀬 耕二, 海野 倫明

    胆と膵　37　(1)　37-44　2016/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  890. Hybrid手術室において集約的加療を要した「たこつぼ型心筋症」の一例

    須田彬, 西宮健介, 圓谷隆治, 羽尾清貴, 松本泰治, 高橋潤, 伊藤健太, 佐藤英昭, 森川孝則, 海野倫明, 下川宏明

    日本循環器学会東北地方会(Web)　162nd　TOHOKU162,12 (WEB ONLY)　2016

  891. 【膵癌血管浸潤例の外科切除適応と治療ストラテジー:Up to date 2016】 治療成績からみた各治療法の意義と限界 膵癌に対する腹腔動脈合併膵体尾部切除成績

    元井 冬彦, 高舘 達之, 前田 晋平, 有明 恭平, 林 洋毅, 水間 正道, 内藤 剛, 海野 倫明

    胆と膵　37巻　(7号)　675-680　2016

    More details Close

    膵癌に対する動脈合併切除の可否は依然議論の余地がある。進行胃癌に対する術式として報告されたAppleby手術は、全胃を温存し腹腔動脈周囲に浸潤する膵体部癌に対する根治術式(DP-CAR)として大規模施設を中心に施行されている。本術式には膵頭アーケードから固有肝動脈への血流温存が必要であり、手術適応を慎重に判断する必要がある。通常の尾側膵切除に比べて侵襲が大きく、術後合併症も高率に発生するが、腹腔動脈周囲の神経叢への浸潤に対しては有効な術式である。2005〜2015年に膵体尾部癌に対する尾側膵切除は113例でDP-CARは32例であった。膵外神経叢浸潤陽性では、DP-CAR施行例が、通常のDPに比べ有意に生存期間を延長した(P&lt;0.01)。症例の選択には、腫瘍局所の進展度とともに、常に不顕性転移の存在を念頭に評価する必要があり、術前治療による症例の選択も有効な方法と考えられる。(著者抄録)

  892. 【肝胆膵外科における脈管侵襲と血行再建】 門脈浸潤を伴う胆嚢癌に対する手術

    林 洋毅, 深瀬 耕二, 益田 邦洋, 海野 倫明

    手術　70巻　(12号)　1577-1587　2016

    DOI： 10.18888/J00620.2017051775 　

  893. 異時性多発肝外胆管癌の1例

    佐藤 龍一郎, 林 洋毅, 元井 冬彦, 古川 徹, 海野 倫明

    日本臨床外科学会雑誌　77巻　(10号)　2531-2537　2016

    Publisher: Japan Surgical Association

    DOI： 10.3919/jjsa.77.2531 　

    ISSN： 1345-2843

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    症例は68歳,男性.62歳時,肝門部領域胆管癌に対し,左肝切除+尾状葉切除,肝外胆管切除術を施行した.術前ERCPでは膵・胆管合流異常は認めていない.腫瘍は肝門部領域に主座を置く2cm大の結節浸潤型の腫瘤で,組織学的には中分化型管状腺癌,切除断端は陰性,T2bN0M0 Stage IIであった.術後は無再発で経過していたが,6年後のCTで膵頭部に直径3cmの腫瘤を認めた.膵頭十二指腸切除術を施行.腫瘍は遠位膵内胆管に主座を置き,膵実質内に浸潤していた.膵後面リンパ節に転移を認め,遠位膵内胆管原発の粘液癌,T3N1M0 Stage IIBであった.免疫染色では,初回標本はSMAD4-,MUC1+/MUC2-/MUC5AC+,2回目はSMAD4+,MUC1+/MUC2+/MUC5AC-であった.初回手術から6年が経過し,両者の組織型が大きく異なることから,肝外胆管癌の異時性重複癌と診断した.(著者抄録)

  894. 漢方薬を導入した臨床栄養の新しい展開 幽門側胃切除術後クリニカルパスへの六君子湯の導入の効果

    工藤 克昌, 大沼 忍, 石田 晶玄, 小原 恵, 小林 実, 長尾 宗紀, 渡辺 和宏, 井本 博文, 有明 恭平, 青木 修一, 志村 充広, 水間 正道, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　238-238　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  895. Metachronous multicentric pancreatic cancer with multiple intraductal papillary mucinous neoplasms (IPMN)

    SHIMURA Mitsuhiro, NAITOH Takeshi, EGAWA Shinichi, FUJISHIMA Fumiyoshi, KANNO Atsushi, HIROTA Morihisa, MASAMUNE Atsushi, SHIMOSEGAWA Tooru, UNNO Michiaki, MIZUMA Masamichi, OKADA Takaho, KATAGIRI Munetoshi, SAKATA Naoaki, NAKAGAWA Kei, HAYASHI Hiroki, MORIKAWA Takanori, MOTOI Fuyuhiko

    Journal of the Japan Pancreas Society　31　(1)　93-100　2016

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.31.93 　

    ISSN： 0913-0071

    eISSN： 1881-2805

    More details Close

    We report a rare surgical case of metachronous multicentric pancreatic cancer with multiple intraductal papillary mucinous neoplasms (IPMN). A 58-year-old woman with diabetes mellitus and a family history of pancreatic cancer (her father suffered from pancreatic cancer), was admitted to our hospital because of backache in November 2008. Distal pancreatectomy was performed for pancreatic cancer of the body concomitant with multiple IPMNs of uncinate process and distal pancreas in April 2009. Histopathological investigation revealed well-differentiated tubular adenocarcinoma concomitant with branch duct type IPMN. The final diagnosis based on general rules of JPS was T3N0M0, Stage III (R0). Although the margin of the surgical specimen was negative for carcinoma, a surgical specimen near the pancreatic stump showed PanIN1A-1B. Thirty-seven months after resection, the serum CA 19-9 value was elevated. Imaging examinations revealed a mass in the remnant pancreas. Forty-six months after the initial surgery, total pancreatectomy with portal vein resection was performed. Although the tumor was pathologically diagnosed as well-differentiated tubular adenocarcinoma, multicentric carcinogenesis was suggested because of histological differentiation from the initial tumor. The main tumor had no continuity with a branch duct type IPMN of the uncinate process. Therefore, the patient was diagnosed as metachronous multicentric pancreatic cancer concomitant with multiple IPMNs.

  896. 膵頭十二指腸切除術におけるcontrolling nutritional statusを用いた栄養スクリーニングと術後合併症の検討

    石田 晶玄, 元井 冬彦, 志村 充広, 盛 彬子, 小原 恵, 小林 実, 青木 修一, 有明 恭平, 工藤 克昌, 大沼 忍, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　206-206　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  897. 小児腸管機能不全に対する栄養治療戦略と問題点 腸管不全症例の中心静脈ポートカテーテル感染に対する抗菌剤/抗真菌剤併用ロック療法の有用性の検討(第1報)

    渡辺 和宏, 長尾 宗紀, 大沼 忍, 工藤 克昌, 井本 博文, 志村 充広, 小原 恵, 小林 実, 青木 修一, 有明 恭平, 石田 晶玄, 水間 正道, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　225-225　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  898. 緩和ケアにおける栄養学的リスクマネジメント がん性消化管閉塞に対する緩和手術と予後評価によるリスクマネジメント

    小原 恵, 大沼 忍, 工藤 克昌, 石田 晶玄, 小林 実, 青木 修一, 井本 博文, 有明 恭平, 渡辺 和宏, 長尾 宗紀, 水間 正道, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　229-229　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  899. 膵癌術前・術後CONUT値の推移に影響する因子

    元井 冬彦, 志村 充広, 小原 恵, 青木 修一, 有明 恭平, 石田 晶玄, 工藤 克昌, 水間 正道, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　287-287　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  900. 膵癌術前補助療法におけるCRP値の推移と術前栄養状態との関係

    青木 修一, 水間 正道, 元井 冬彦, 志村 充広, 小原 恵, 有明 恭平, 井本 博文, 石田 晶玄, 工藤 克昌, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　437-437　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  901. 膵全摘術1年後の体重変化と体組織変化の関係

    志村 充広, 水間 正道, 盛 彬子, 青木 修一, 石田 晶玄, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　437-437　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  902. 潰瘍性大腸炎に対する回腸肛門吻合術後にストマ再造設を要した症例の検討

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 唐澤 秀明, 大沼 忍, 工藤 克昌, 高橋 真紀, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　32　(1)　119-119　2016/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  903. 褥瘡に対する栄養補助食品の治癒促進効果を検討する多職種共同前向き臨床研究モデルの立ち上げ

    有明 恭平, 元井 冬彦, 岡本 智子, 稲村 なお子, 中川 圭, 水間 正道, 石田 晶玄, 青木 修一, 香取 幸夫, 海野 倫明

    日本静脈経腸栄養学会雑誌　31　(1)　416-416　2016/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

    eISSN： 2189-017X

  904. 胆嚢悪性リンパ腫の1例

    盛 彬子, 中川 圭, 川口 桂, 岡田 良, 益田 邦洋, 深瀬 耕二, 水間 正道, 大塚 英郎, 森川 孝則, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    東北医学雑誌　127　(2)　188-189　2015/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  905. Single-nucleotide polymorphisms of DPYD predict adverse events associated with 5-fluorouracil in patients with gastrointestinal cancer

    S. Ohnuma, M. Toshima, K. Miura, K. Kudoh, M. Ishida, H. Karasawa, H. Musha, F. Motoi, T. Naitoh, M. Unno

    ANNALS OF ONCOLOGY　26　11-11　2015/12

    ISSN： 0923-7534

    eISSN： 1569-8041

  906. Postoperative glycemic control and incidents of infectious complications after pancreaticoduodenectomy

    12　(6)　649-656　2015/12

    Publisher: 日本外科感染症学会

    ISSN： 1349-5755

  907. Surgical oncology for pancreatic cancer; Future perspective

    Michiaki Unno

    Journal of Japanese Society of Gastroenterology　112　(12)　2113-2118　2015/12/01

    Publisher: Japanese Society of Gastroenterology

    ISSN： 0446-6586

  908. 膵原発Mixed acinar-endocrine carcinoma(MAEC)の1例

    中野 絵里子, 菅野 敦, 正宗 淳, 本郷 星仁, 吉田 直樹, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 下瀬川 徹, 深瀬 耕二, 元井 冬彦, 海野 倫明, 笠島 敦子

    東北医学雑誌　127　(2)　186-187　2015/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  909. 術前治療施行膵癌切除後3年の残膵再発に対し根治切除を施行した1例

    客本 ゆき恵, 水間 正道, 益田 邦洋, 有明 恭平, 前田 晋平, 川口 桂, 岡田 良, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 元井 冬彦, 海野 倫明, 菅野 敦, 下瀬川 徹

    東北医学雑誌　127　(2)　192-193　2015/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  910. 膵癌・胆管癌術後転移に対する切除例の検討

    水間 正道, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 岡田 良, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 内藤 剛, 元井 冬彦, 海野 倫明, 岡田 克典, 下瀬川 徹

    東北医学雑誌　127　(2)　194-194　2015/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  911. 肥満・糖尿病治療の飛躍に向けて 内科・外科医の技の癒合 スリーブバイパス術の糖尿病改善効果と今後の方向性

    内藤 剛, 田中 直樹, 長尾 宗紀, 渡辺 和宏, 井本 博文, 宮地 智洋, 土屋 堯裕, 大沼 忍, 阿部 友哉, 武者 宏昭, 森川 孝則, 林 洋毅, 中川 圭, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　SY8-4　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  912. 肝頭側腫瘍(S7、S8)に対する腹腔鏡下肝切除術における工夫 肝S7、S8領域病変に対する低侵襲治療 肋間ポートを用いない腹腔鏡下肝部分切除術

    森川 孝則, 石田 昌玄, 青木 豪, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 深瀬 耕二, 大沼 忍, 林 洋毅, 武者 宏昭, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　WS5-5　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  913. 解剖学的および発生学的な間膜解剖に基づいた腹腔鏡下脾臓摘出術

    石田 晶玄, 森川 孝則, 青木 豪, 岡田 良, 前田 晋平, 工藤 克昌, 大沼 忍, 深瀬 耕二, 長尾 宗紀, 阿部 友哉, 林 洋毅, 中川 圭, 武者 宏昭, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS172-3　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  914. 病的肥満症に対する減量手術における"患者参加型手術体位シミュレーション"

    千葉 壮太, 高橋 光恵, 内藤 剛, 田中 直樹, 井本 博文, 長尾 宗紀, 武者 宏昭, 海野 倫明, 佐藤 裕子

    日本内視鏡外科学会雑誌　20　(7)　OS272-1　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  915. 単孔式手術かNeedlescopic Surgeryか 低侵襲内視鏡手術の王道は? 時代とともに変わりゆくNeedlescopic surgery

    内藤 剛, 田中 直樹, 青木 豪, 井本 博文, 唐澤 秀明, 工藤 克昌, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 阿部 友哉, 武者 宏昭, 森川 孝則, 中川 圭, 元井 冬彦, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　DS13-1　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  916. 腹腔鏡下スリーブ状胃切除 各施設の手技と工夫 東北大学病院のスリーブ状胃切除術の手術手技

    田中 直樹, 内藤 剛, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 大沼 忍, 中川 圭, 林 洋毅, 森川 孝則, 武者 宏昭, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　PD6-2　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  917. 腹腔鏡下直腸切除における縫合不全症例の検討

    唐澤 秀明, 大沼 忍, 阿部 友哉, 渡辺 和宏, 長尾 宗紀, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS5-10　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  918. 逆流防止弁形成腹腔鏡補助下噴門側胃切除術の手技および治療成績

    武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS100-4　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  919. 胃GISTにおける病態別手術術式の検討

    青木 豪, 唐澤 秀明, 杉沢 徳彦, 井本 博文, 工藤 克昌, 田中 直樹, 大沼 忍, 阿部 友哉, 林 洋毅, 中川 圭, 森川 孝則, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS109-1　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  920. 胃穹窿部の最大径70mmのGISTに対し腹腔鏡下切除術を施行した1例

    井本 博文, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 森川 孝則, 石田 晶玄, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS109-2　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  921. 高齢者急性胆嚢炎症例に対する早期腹腔鏡下胆嚢摘出術の検討

    工藤 克昌, 森川 孝則, 阿部 友哉, 武者 宏昭, 大沼 忍, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 青木 豪, 唐澤 秀明, 前田 晋平, 井本 博文, 石田 晶玄, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS135-4　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  922. 当科での腹腔鏡補助下大腸全摘術の工夫と治療成績

    阿部 友哉, 長尾 宗紀, 渡辺 和宏, 井本 博文, 唐澤 秀明, 大沼 忍, 武者 宏昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS196-2　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  923. 当科におけるクローン病に対する腹腔鏡手術についての検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 井本 博文, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS268-8　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  924. 直腸肛門部悪性腫瘍に対する腹腔鏡下直腸切断術の短期治療成績

    大沼 忍, 阿部 友哉, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 石田 晶玄, 田中 直樹, 長尾 宗紀, 武者 宏昭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　20　(7)　OS294-4　2015/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  925. Cholestatic liver injury after biliary reconstruction impairs transplanted islet viability and function due to oxidative stress

    Naoaki Sakata, Fuyuhiko Motoi, Hiroki Hayashi, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Shojiro Sawada, Takeshi Naitoh, Yu Katayose, Masafumi Goto, Michiaki Unno

    XENOTRANSPLANTATION　22　S5-S5　2015/11

    ISSN： 0908-665X

    eISSN： 1399-3089

  926. Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study (vol 6, pg 34004, 2015)

    Hideo Baba, Yoshifumi Baba, Shinji Uemoto, Kazuhiro Yoshida, Akio Saiura, Masayuki Watanabe, Yoshihiko Maehara, Eiji Oki, Yasuharu Ikeda, Hiroyuki Matsuda, Masakazu Yamamoto, Mitsuo Shimada, Akinobu Taketomi, Michiaki Unno, Kenichi Sugihara, Yutaka Ogata, Susumu Eguchi, Seigo Kitano, Kazuo Shirouzu, Yasumitsu Saiki, Hiroshi Takamori, Masaki Mori, Toshihiko Hirata, Go Wakabayashi, Norihiro Kokudo

    ONCOTARGET　6　(36)　39384-39384　2015/11

    DOI： 10.18632/oncotarget.6335 　

    eISSN： 1949-2553

  927. Adjuvant and neoadjuvant therapy for resectable pancreatic cancer

    Hideki Ueno, Takuji Okusaka, Tomoo Kosuge, Fuyuhiko Motoi, Michiaki Unno

    ANNALS OF ONCOLOGY　26　9-9　2015/11

    ISSN： 0923-7534

    eISSN： 1569-8041

  928. CHOLESTATIC LIVER INJURY AFTER BILIARY RECONSTRUCTION IMPAIRS TRANSPLANTED ISLET VIABILITY AND FUNCTION DUE TO OXIDATIVE STRESS.

    Naoaki Sakata, Fuyuhiko Motoi, Hiroki Hayashi, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Shojiro Sawada, Takeshi Naitoh, Yu Katayose, Masafumi Goto, Michiaki Unno

    TRANSPLANTATION　99　(11)　S7-S7　2015/11

    ISSN： 0041-1337

    eISSN： 1534-6080

  929. 肝胆膵手術周術期管理において口腔ケアは有用か?

    水間 正道, 岡田 良, 阿部 友哉, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 佐藤 しづ子, 庄司 憲明, 笹野 高嗣, 海野 倫明

    日本外科感染症学会雑誌　12　(5)　581-581　2015/11

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  930. 胆管癌肝肺転移再発に対し切除後3年無病生存が得られた1例

    青木 修一, 水間 正道, 大矢内 幹, 吉田 寛, 岡田 良, 阿部 友哉, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 岡田 克典, 海野 倫明

    癌と化学療法　42　(12)　1573-1575　2015/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  931. 初回手術より12年後に診断された直腸癌局所再発に対し骨盤内臓全摘術を施行した1例

    小原 恵, 大沼 忍, 唐澤 秀明, 渡辺 和宏, 工藤 克昌, 石田 晶玄, 井本 博文, 青木 豪, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    癌と化学療法　42　(12)　2337-2339　2015/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  932. 膵頭部癌に合併した胆管原発神経内分泌腫瘍の1例

    客本 ゆき恵, 水間 正道, 青木 豪, 前田 晋平, 岡田 良, 川口 桂, 阿部 友哉, 坂田 直昭, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　698-698　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  933. 高齢者に対する外科治療(肝、胆、膵) 切除企図・高齢者膵癌の外科治療戦略 術前・術後化学療法の意義

    元井 冬彦, 前田 晋平, 有明 恭平, 岡田 良, 川口 桂, 益田 邦洋, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　374-374　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  934. 膵IPMNの手術適応と術式 国際診療ガイドラインからみたIPMNに対する腹腔鏡下手術の適応

    森川 孝則, 元井 冬彦, 水間 正道, 川口 桂, 益田 邦洋, 岡田 良, 青木 豪, 石田 昌玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　428-428　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  935. Borderline resectable膵癌に対する治療戦略 Borderline resectable膵癌における術前化学療法の意義

    林 洋毅, 元井 冬彦, 水間 正道, 森川 孝則, 中川 圭, 坂田 直昭, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 川口 桂, 有明 恭平, 前田 晋平, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　453-453　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  936. 膵癌に対する腹腔鏡下膵尾側切除術の課題と考察

    石田 晶玄, 森川 孝則, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　510-510　2015/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.76.510 　

    ISSN： 1345-2843

  937. 自家膵島移植後5年間良好な耐糖能を維持している膵動静脈奇形の1例

    坂田 直昭, 元井 冬彦, 林 洋毅, 吉松 軍平, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 大塚 英郎, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　552-552　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  938. 高齢者における膵頭十二指腸切除術周術期リスク因子とその管理

    大塚 英郎, 有明 恭平, 前田 晋平, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　650-650　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  939. 膵癌腹腔洗浄細胞診陽性例におけるFDG-PETの意義

    前田 晋平, 水間 正道, 林 洋毅, 川口 桂, 森川 孝則, 中川 圭, 坂田 直昭, 大塚 英郎, 深瀬 耕二, 石田 晶玄, 岡田 良, 益田 邦洋, 内藤 剛, 元井 冬彦, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　762-762　2015/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.76.762 　

    ISSN： 1345-2843

  940. 膵頭十二指腸切除術後4年目に挙上空腸の静脈瘤から出血し、内視鏡的硬化療法にて救命した1例

    伊勢 一郎, 石田 晶玄, 前田 晋平, 岡田 良, 深瀬 耕二, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　896-896　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  941. 【消化器・一般外科手術のPearls & Tips-ワンランク上の手術を達成する技と知恵】 胆道 胆管切除+胆管空腸吻合

    中川 圭, 大塚 英郎, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    臨床外科　70　(11)　204-209　2015/10

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1407210955 　

    ISSN： 0386-9857

  942. すぐに役立つ肝臓・胆道・膵臓手術の周術期管理法 当教室における膵頭十二指腸切除術の周術期管理標準化のインパクト

    水間 正道, 元井 冬彦, 前田 晋平, 青木 修一, 志村 充広, 橘 知睦, 盛 彬子, 石居 健太郎, 深瀬 正彦, 川口 桂, 中川 圭, 森川 孝則, 林 洋毅, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　459-459　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  943. 保険収載された肥満外科治療

    田中 直樹, 内藤 剛, 井本 博文, 長尾 宗紀, 武者 宏昭, 海野 倫明

    臨床外科　70　(10)　1250-1255　2015/10

    Publisher: (株)医学書院

    ISSN： 0386-9857

  944. ACSにおける内視鏡外科の役割 高齢者における急性胆嚢炎症例に対する早期腹腔鏡下胆嚢摘出術の検討

    工藤 克昌, 前田 晋平, 佐藤 純, 大沼 忍, 武者 宏昭, 阿部 友哉, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    Japanese Journal of Acute Care Surgery　5　(2)　149-149　2015/10

    Publisher: 日本Acute Care Surgery学会

  945. 外傷性十二指腸穿孔術後の難治性瘻孔に対し保存的加療で軽快した1例

    佐藤 純, 工藤 克昌, 前田 晋平, 青木 豪, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    Japanese Journal of Acute Care Surgery　5　(2)　197-197　2015/10

    Publisher: 日本Acute Care Surgery学会

  946. 合併症ゼロを目指した再建、吻合手術手技(胆道、膵臓) 適切な胆管空腸吻合の確立に向けた取り組み

    中川 圭, 岡田 良, 川口 桂, 益田 邦洋, 深瀬 耕二, 水間 正道, 大塚 英郎, 大沼 忍, 坂田 尚昭, 林 洋毅, 武者 宏昭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　385-385　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  947. 超高齢者(80歳以上)に対する外科治療 超高齢者における腹腔鏡下胃切除の治療成績

    武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　435-435　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  948. IBDの治療戦略 術前のタクロリムス投与は潰瘍性大腸炎の周術期成績に影響を与えるか?

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 唐澤 秀明, 大沼 忍, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　460-460　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  949. 胃GISTに対する手術治療の検討

    杉沢 徳彦, 唐澤 秀明, 佐藤 好宏, 井本 博文, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　634-634　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  950. 当科におけるGIST肝転移症例の検討

    佐藤 好宏, 唐澤 秀明, 井本 博文, 杉沢 徳彦, 大沼 忍, 大塚 英郎, 水間 正道, 坂田 直昭, 武者 宏昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　635-635　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

    eISSN： 1882-5133

  951. 横行結腸癌における腹腔鏡手術の手技と成績

    阿部 友哉, 大沼 忍, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　669-669　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  952. 肛門管癌に対する会陰再建術 腹直筋皮弁作成における術中ICG造影の有用性

    大沼 忍, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 佐々木 宏之, 工藤 克昌, 小林 実, 田中 直樹, 阿部 智哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　671-671　2015/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.76.671 　

    ISSN： 1345-2843

  953. クローン病の癌化症例の特徴および早期診断・予防にむけた当科での取り組み

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 唐澤 秀明, 井本 博文, 青木 豪, 工藤 克昌, 武者 宏昭, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　787-787　2015/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  954. 術前診断に苦慮した成人胃重複症の1切除例

    盛 彬子, 武者 宏昭, 井本 博文, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(増刊)　1036-1036　2015/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.76.1036 　

    ISSN： 1345-2843

  955. ヒト大腸癌患者におけるCripto-1の発現とその予後的重要性

    佐藤 純, 唐澤 秀明, 中山 瞬, 前田 晋平, 大沼 忍, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌学会総会記事　74回　J-1069　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  956. 大腸癌におけるHexokinase 2発現の臨床病理学的検討

    片桐 宗利, 鈴木 貴, 唐澤 秀明, 高木 清司, 前田 晋平, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌学会総会記事　74回　P-1326　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  957. 肝外胆管癌におけるNotch signalの関与と治療標的としての可能性

    青木 修一, 水間 正道, 高橋 弥生, 土師 陽一, 岡田 良, 阿部 友哉, 唐澤 秀明, 林 洋毅, 元井 冬彦, 片寄 友, 玉井 恵一, 石井 直人, 海野 倫明

    日本癌学会総会記事　74回　J-1214　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  958. 大腸癌の発癌過程においてWnt/β-cateninシグナルは抗癌剤耐性関連ABCトランスポーターであるABCC3(MRP3)の発現を抑制する

    小林 実, 大沼 忍, 唐澤 秀明, 工藤 克昌, 石田 晶玄, 武者 宏昭, 元井 冬彦, 内藤 剛, 中山 啓子, 海野 倫明

    日本癌学会総会記事　74回　J-1351　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  959. 多剤耐性ABCトランスポーターに対する天然化合物の直接抑制効果

    大沼 忍, 小林 実, 石田 晶玄, 工藤 克昌, 唐澤 秀明, 佐々木 宏之, 武者 宏昭, 元井 冬彦, 内藤 剛, Ambudkar Suresh, Limtrakul Porngarm, 海野 倫明

    日本癌学会総会記事　74回　P-3350　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  960. 膵癌組織におけるCRH発現と生存予後の関連

    佐藤 菜保子, 片寄 友, 川口 桂, 大塚 英郎, 森川 孝則, 中川 圭, 元井 冬彦, 内藤 剛, 高木 清司, 鈴木 貴, 福土 審, 佐藤 冨美子, 海野 倫明

    日本癌治療学会誌　50　(3)　2523-2523　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  961. 膵臓 局所進行膵がんの手術療法 膵癌切除術後S1療法の有効性 切除術後腫瘍マーカーによる層別化の重要性

    元井 冬彦, 川口 桂, 岡田 良, 益田 邦洋, 青木 豪, 石田 昌玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1142-1142　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  962. Clinical features and management of anorectal cancer in Crohn's disease: Japanese single centre study

    K. Watanabe, M. Nagao, T. Abe, H. Imoto, N. Tanaka, K. Kudo, T. Aoki, H. Karasawa, T. Tsuchiya, M. Kobayashi, M. Mizuma, H. Hayashi, T. Morikawa, K. Nakagawa, N. Sakata, S. Ohnuma, H. Musha, F. Motoi, T. Naitoh, M. Unno

    EUROPEAN JOURNAL OF CANCER　51　S357-S357　2015/09

    ISSN： 0959-8049

    eISSN： 1879-0852

  963. Surgery for pancreatic tumor recurrence after initial pancreatectomy

    70　(9)　1108-1112　2015/09

    Publisher: 医学書院

    ISSN： 0386-9857

  964. 再生医療新時代の膵・膵島移植の課題と対応 自家膵島移植における術後胆管炎の移植膵島への影響

    坂田 直昭, 元井 冬彦, 林 洋毅, 青木 豪, 石田 晶玄, 内藤 剛, 澤田 正二郎, 後藤 昌史, 海野 倫明

    移植　50　(総会臨時)　259-259　2015/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  965. 胆管癌を伴う先天性胆道拡張症術後10年目に発症した肝門部胆管癌の1例

    有明 恭平, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 坂田 直昭, 水間 正道, 深瀬 耕二, 石田 晶玄, 益田 邦洋, 川口 桂, 岡田 良, 前田 晋平, 内藤 剛, 元井 冬彦, 海野 倫明

    日本膵・胆管合流異常研究会プロシーディングス　38　68-69　2015/09

    Publisher: 日本膵・胆管合流異常研究会

    ISSN： 1883-4116

  966. 膵臓 切除不能膵がんへのアプローチ Gemcitabine及びS-1不応の進行・再発膵癌に対するmFOLFOX6療法の前向き第II相試験

    川口 桂, 元井 冬彦, 岡田 良, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1405-1405　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  967. IBDに対する癌サーベイランスの現状と今後の展望 当科における直腸肛門部癌を合併したクローン病症例の特徴と早期癌診断へむけた取り組み

    渡辺 和宏, 長尾 宗紀, 大沼 忍, 工藤 克昌, 小林 実, 小原 恵, 小野 智之, 前田 晋平, 佐々木 宏之, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　620-620　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  968. 日本語版IBDQ・SF36v2を用いた潰瘍性大腸炎における術式別のQOLの評価

    小野 智之, 渡辺 和宏, 長尾 宗紀, 大沼 忍, 工藤 克昌, 小林 実, 小原 恵, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　654-654　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  969. 内視鏡治療後に追加腸切除を施行した大腸癌30症例の検討

    小原 恵, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 工藤 克昌, 前田 晋平, 小林 実, 小野 智之, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　657-657　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  970. 当科における高齢者大腸癌(75歳以上)の短期手術成績

    四條 正浩, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 工藤 克昌, 前田 晋平, 小林 実, 小原 恵, 小野 智之, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　686-686　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  971. 直腸癌局所再発に対する外科治療

    大沼 忍, 渡辺 和宏, 長尾 宗紀, 工藤 克昌, 小原 恵, 小林 実, 小野 智之, 前田 晋平, 佐々木 宏之, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　714-714　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

    eISSN： 1882-9619

  972. 傍ストーマヘルニア修復後のメッシュに感染し、膿瘍形成したクローン病の1例

    羽根田 祥, 柴田 近, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 工藤 克昌, 神山 篤史, 高橋 賢一, 西條 文人, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　68　(9)　850-850　2015/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  973. 肝臓 胆嚢・胆管がん治療の進歩 肝門部領域胆管癌に対する集学的治療の検討

    中川 圭, 片寄 友, 盛 彬子, 石居 健太郎, 谷口 肇, 川崎 修平, 青木 修一, 岡田 良, 益田 邦洋, 深瀬 耕二, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　344-344　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  974. 膵臓 局所進行膵がんの手術療法 膵癌術前療法後のCA19-9値<30U/mlへの低下は良好な予後を反映する

    青木 修一, 元井 冬彦, 水間 正道, 村上 義昭, 庄 雅之, 里井 壮平, 本田 五郎, 川井 学, 松本 逸平, 海野 倫明

    日本癌治療学会誌　50　(3)　1146-1146　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  975. 膵臓 局所進行膵がんの手術療法 Initially unresectable pancreatic cancerに対するadjuvant surgeryの意義

    林 洋毅, 元井 冬彦, 青木 修一, 前田 晋平, 川口 桂, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 森川 孝則, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1147-1147　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  976. 膵臓 切除不能膵がんへのアプローチ 膵癌遠隔転移に対する切除介入の効果

    水間 正道, 元井 冬彦, 青木 修一, 前田 晋平, 川口 桂, 大塚 英郎, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1478-1478　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  977. 膵臓 膵がんのバイオマーカー探索 膵癌に対する審査腹腔鏡の安全性および有効性の検討

    森川 孝則, 石田 昌玄, 岡田 良, 青木 豪, 大沼 忍, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1102-1102　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  978. 大腸 大腸がん手術療法の多様な視点 家族性大腸腺腫症に対する手術成績

    大沼 忍, 長尾 宗紀, 阿部 友哉, 唐澤 秀明, 渡辺 和宏, 井本 博文, 青木 豪, 工藤 克昌, 田中 直樹, 武者 宏昭, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本癌治療学会誌　50　(3)　1454-1454　2015/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  979. 新規胆管癌糖蛋白質マーカー,WFA‐positive sialyl‐MUC1の臨床的意義―多施設臨床試験の結果より

    志田隆史, 樋口亮太, 山本雅一, 梛野正人, 露口利夫, 八坂貴宏, 田妻進, 内山和久, 海野倫明, 大河内信弘, 松田厚志, 久野敦, 成松久, 正田純一

    胆道　29　(3)　517　2015/08/31

    ISSN： 0914-0077

  980. Tissue stem cell specific enhancer element identifies two types of stem cells in the corpus epithelium of the stomach

    Junichi Matsuo, Shunichi Kimura, Cai Ping Koh, Md Zakir Hossain, Akihiro Yamamura, Kazuyoshi Kohu, Michiaki Unno, Jimmy Bok Yan So, Feng Zhu, Supriya Srivastava, Teh Meng, Nicholas Barker, Khay Guan Yeoh, Motomi Osato, Yoshiaki Ito

    CANCER RESEARCH　75　2015/08

    DOI： 10.1158/1538-7445.AM2015-LB-139 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  981. Usefulness of genetic markers in pancreatic juice for the diagnosis of pancreatic cancer distinguishing from chronic inflammation: A meta-analysis

    Tatsuo Nata, Masaharu Ishida, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

    CANCER RESEARCH　75　2015/08

    DOI： 10.1158/1538-7445.AM2015-539 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  982. SLEEVE GASTRECTOMY WITH DUODENO-JEJUNAL BYPASS IS A SUITABLE PROCEDURE FOR JAPANESE OBESE DM PATIENTS

    Takeshi Naitoh, Naoki Tanaka, Hirofumi Imoto, Takahiro Tsuchiya, Munenori Nagao, Hiroaki Musha, Shinobu Ohnuma, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno

    OBESITY SURGERY　25　S229-S229　2015/08

    ISSN： 0960-8923

    eISSN： 1708-0428

  983. MK2461 suppress progression of pancreatic cancer disrupting interaction between pancreatic cancer cells and stellate cells

    Koetsu Inoue, Hideo Ohtsuka, Fuyuhiko Motoi, Daisuke Douchi, Shuhei Kawasaki, Kei Kawaguchi, Kunihiro Masuda, Koji Fukase, Shinobu Ohnuma, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

    CANCER RESEARCH　75　2015/08

    DOI： 10.1158/1538-7445.AM2015-404 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  984. 当施設における研修医を対象にしたブタを用いた外科手術トレーニングについて

    伊藤 拓哉, 壹岐 裕子, 兼平 雅彦, 工藤 克昌, 野田 雅史, 海野 倫明

    日本獣医学会学術集会講演要旨集　158回　441-441　2015/08

    Publisher: (公社)日本獣医学会

    ISSN： 1347-8621

  985. 膵・胆管合流異常に併発した肝門部胆管癌術後5年目に発生した膵内遺残胆管癌の1例

    中野 絵里子, 菅野 敦, 正宗 淳, 三浦 晋, 廣田 衛久, 森川 孝則, 林 洋毅, 海野 倫明, 藤島 史喜, 下瀬川 徹

    胆道　29　(3)　660-660　2015/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  986. 【慢性膵炎・急性膵炎に対する外科的アプローチ】 慢性膵炎 慢性膵炎に対するFrey手術

    石田 晶玄, 岡田 恭穂, 元井 冬彦, 海野 倫明

    手術　69　(9)　1311-1315　2015/08

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  987. 新規約改訂による遠位胆管癌の問題点

    青木 修一, 水間 正道, 海野 倫明

    胆道　29　(3)　555-555　2015/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  988. 定量的標的絶対プロテオミクスによる膵癌化学療法の感受性予測

    大塚 英郎, 川口 桂, 井上 享悦, 深瀬 耕二, 益田 邦洋, 元井 冬彦, 片寄 友, 立川 正憲, 寺崎 哲也, 海野 倫明

    日本消化器外科学会総会　70回　O-9　2015/07

    Publisher: (一社)日本消化器外科学会

  989. 肝内胆管癌リンパ節転移症例に対する胆管切除を伴うリンパ節郭清の意義

    益田 邦洋, 吉田 寛, 深瀬 耕二, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　O-53　2015/07

    Publisher: (一社)日本消化器外科学会

  990. PNETに対する治療 NECにおける組織学的分類の必要性

    青木 豪, 森川 孝則, 大塚 英郎, 坂田 直昭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　70回　RS-1　2015/07

    Publisher: (一社)日本消化器外科学会

  991. 膵頭十二指腸切除術症例におけるcontrolling nutritional status法による術前栄養評価と術後合併症の評価

    石田 晶玄, 元井 冬彦, 工藤 克昌, 大沼 忍, 坂田 直昭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　O-40　2015/07

    Publisher: (一社)日本消化器外科学会

    DOI： 10.11244/jspen.33.641 　

  992. 炎症性腸疾患における手術手技と工夫 合併症低減をめざした潰瘍性大腸炎に対する大腸亜全摘におけるカテーテル直腸粘液瘻造設術

    舟山 裕士, 鈴木 秀幸, 高橋 賢一, 羽根田 祥, 生澤 史江, 渡辺 和宏, 工藤 克昌, 神山 篤史, 長尾 宗紀, 海野 倫明

    日本消化器外科学会総会　70回　RS-28　2015/07

    Publisher: (一社)日本消化器外科学会

  993. 消化器外科領域における基礎研究 十二指腸空腸バイパスにおけるbiliopancreatic limbの機能 Metabolic surgeryの機序解明にむけた新知見

    宮地 智洋, 内藤 剛, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 土屋 堯裕, 河野 えみ子, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　WS-10　2015/07

    Publisher: (一社)日本消化器外科学会

  994. 肝臓の外科解剖、特に亜区域の新たな考え方 Portal segmentationの立場から見た尾状葉の概念 左/右尾状葉、尾状葉突起をsubsegmentとして捉えられるか

    青木 修一, 水間 正道, 岡田 良, 阿部 友哉, 林 洋毅, 中川 圭, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　WS-7　2015/07

    Publisher: (一社)日本消化器外科学会

  995. 膵癌肺転移に対する外科的切除の意義

    水間 正道, 元井 冬彦, 青木 修一, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 片寄 友, 近藤 丘, 海野 倫明

    日本消化器外科学会総会　70回　P-85　2015/07

    Publisher: (一社)日本消化器外科学会

  996. 膵癌術前治療による動脈接触角度の変化が切除可否に与える影響

    伊関 雅裕, 水間 正道, 青木 修一, 岡田 良, 阿部 友哉, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　P-123　2015/07

    Publisher: (一社)日本消化器外科学会

  997. 進行胃癌に対する腹腔鏡下胃切除術の治療成績

    武者 宏昭, 工藤 克昌, 青木 豪, 田中 直樹, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　P-8　2015/07

    Publisher: (一社)日本消化器外科学会

  998. 肥満患者に対する減量手術 Metabolic surgeryとしてのスリーブバイパス術導入の必要性

    内藤 剛, 田中 直樹, 宮地 智洋, 土屋 堯裕, 武者 宏昭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　RS-14　2015/07

    Publisher: (一社)日本消化器外科学会

  999. 肥満症手術における体組成変化

    田中 直樹, 内藤 剛, 小野 智之, 河野 えみ子, 土屋 堯裕, 宮地 智洋, 長尾 宗紀, 渡辺 和宏, 武者 宏昭, 海野 倫明

    日本消化器外科学会総会　70回　P-134　2015/07

    Publisher: (一社)日本消化器外科学会

  1000. TRPA1刺激による結腸運動亢進・排便誘発作用の検討

    染谷 崇徳, 長尾 宗紀, 柴田 近, 田中 直樹, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　P-143　2015/07

    Publisher: (一社)日本消化器外科学会

  1001. 悪性腸閉塞に対する緩和手術の意義

    小原 恵, 大沼 忍, 工藤 克昌, 石田 晶玄, 阿部 友哉, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　70回　P-162　2015/07

    Publisher: (一社)日本消化器外科学会

  1002. 当科におけるクローン病術後の腸管不全症例の現状およびCVポート感染に対する抗菌剤ロック療法の試み

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 大沼 忍, 工藤 克昌, 田中 直樹, 武者 宏昭, 羽根田 祥, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　70回　P-145　2015/07

    Publisher: (一社)日本消化器外科学会

  1003. 胃癌手術患者の生存転帰に対するmodified Glasgow prognostic scoreの影響

    杉沢 徳彦, 工藤 克昌, 田中 直樹, 武者 宏昭, 石田 晶玄, 大沼 忍, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　P-175　2015/07

    Publisher: (一社)日本消化器外科学会

  1004. 印刷業職業性胆管癌に対する化学放射線療法と根治的肝切除の経験

    中川 圭, 片寄 友, 石田 和之, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 久保 正二, 海野 倫明

    日本消化器病学会雑誌　112　(7)　1341-1347　2015/07

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1005. 炎症性腸疾患における手術手技と工夫 当科における潰瘍性大腸炎に対する腹腔鏡補助下2期分割手術の手技と治療成績

    阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　70回　RS-28　2015/07

    Publisher: (一社)日本消化器外科学会

  1006. 当科におけるタクロリムス不応潰瘍性大腸炎手術症例の検討

    長尾 宗紀, 渡辺 和宏, 阿部 友哉, 唐澤 秀明, 大沼 忍, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　70回　O-61　2015/07

    Publisher: (一社)日本消化器外科学会

  1007. Liver resection : What to do in order to go beyond the limits of resection

    253　(10)　1047-1052　2015/06/06

    Publisher: 医歯薬出版

    ISSN： 0039-2359

  1008. バイオマーカーをめぐるQ&A(Question 13) 薬剤トランスポーター定量は抗癌剤感受性バイオマーカーとして有用か?

    川口 桂, 海野 倫明

    Surgery Frontier　22　(2)　183-186　2015/06

    Publisher: (株)メディカルレビュー社

    ISSN： 1340-5594

  1009. 腹腔鏡下尾側膵切除術の安全性向上、定型化を目指して 当施設の手術手技の変遷と工夫

    森川 孝則, 青木 豪, 石田 昌玄, 川口 桂, 益田 邦洋, 岡田 良, 薮内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　463-463　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1010. Can neoadjuvant therapy improve the survival of pancreatic carcinoma planned resection?

    15　(6)　537-542　2015/06

    Publisher: 科学評論社

    ISSN： 1881-6568

  1011. ストップリバウンド/チーム医療としての取り組み なぜリバウンドするのか? 術後の自己管理を主体的に行うようになるための医療者の関わりについて考える

    岡本 智子, 稲村 なお子, 武田 みゆき, 梅木 諒, 金子 直美, 澤田 正二郎, 片桐 秀樹, 田中 直樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　47-47　2015/06

    Publisher: 日本肥満症治療学会

  1012. Metabolic Surgeryの理論的根拠 Metabolic surgeryの作用機序 基礎的実験の結果から

    内藤 剛, 生澤 史江, 井本 博文, 宮地 智洋, 土屋 堯裕, 河野 えみ子, 田中 直樹, 長尾 宗紀, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　53-53　2015/06

    Publisher: 日本肥満症治療学会

  1013. 食餌誘発性NASHモデルラットにおける十二指腸空腸バイパス手術のNASH改善効果の検討

    土屋 堯裕, 長尾 宗紀, 田中 直樹, 宮地 智洋, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　136-136　2015/06

    Publisher: 日本肥満症治療学会

  1014. Biliopancreatic limbはエネルギー代謝、糖代謝改善、血中胆汁酸増加作用を有する 2型糖尿病ラットを用いた十二指腸空腸バイパスモデルの研究から

    宮地 智洋, 内藤 剛, 長尾 宗紀, 田中 直樹, 井本 博文, 土屋 堯裕, 河野 えみ子, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　137-137　2015/06

    Publisher: 日本肥満症治療学会

  1015. 肝内胆管癌の治療方針 肝内胆管癌に対する胆管切除を伴うリンパ節郭清の意義

    益田 邦洋, 中川 圭, 深瀬 耕二, 岡田 良, 川口 桂, 青木 豪, 石田 晶玄, 藪内 伸一, 水間 正道, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　399-399　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1016. 迷わない確実な膵吻合術を目指して1 膵管空腸粘膜吻合の手技・成績の確立に向けた取り組み

    中川 圭, 元井 冬彦, 片寄 友, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 藪内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 岡田 恭穂, 森川 孝則, 吉田 寛, 内藤 剛, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　418-418　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1017. Borderline resectable膵癌とその治療方針 Borderline Resectable膵癌に対する術前治療の意義

    林 洋毅, 元井 冬彦, 吉田 寛, 森川 孝則, 中川 圭, 岡田 恭穂, 水間 正道, 大塚 英郎, 坂田 直昭, 深瀬 耕二, 藪内 伸一, 石田 晶玄, 益田 邦洋, 川口 桂, 岡田 良, 青木 豪, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　430-430　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1018. 門脈塞栓術後の残肝容積率変化に影響を与える因子の検討

    深瀬 耕二, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 藪内 伸一, 水間 正道, 坂田 直昭, 大塚 英郎, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　449-449　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1019. 膵頭十二指腸切術後の膵液量は術後膵瘻の予測因子となり得る

    石居 健太郎, 石田 晶玄, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 薮内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　474-474　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1020. 膵神経内分泌腫瘍と膵漿液性嚢胞腫瘍を合併し膵全摘術を施行したvon Hippel-Lindau病の1例

    四條 正浩, 深瀬 耕二, 大塚 英郎, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 薮内 伸一, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　523-523　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1021. 膵頭十二指腸切除術におけるドレーン管理 監視培養や留置日数の現状分析

    水間 正道, 岡田 恭穂, 畠 達夫, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　561-561　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1022. 胆管癌のFDG-PET SUVmax値から見たネオアジュバント化学放射線療法の効果

    片寄 友, 中川 圭, 吉田 寛, 林 洋毅, 森川 孝則, 岡田 恭穂, 坂田 直昭, 大塚 英郎, 水間 正道, 深瀬 耕二, 藪内 伸一, 石田 晶玄, 青木 豪, 益田 邦洋, 川口 桂, 岡田 良, 山本 久仁治, 内藤 剛, 元井 冬彦, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　583-583　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1023. FDG-PET、Diffusion MRIを用いたIPMNの悪性度診断

    岡田 良, 水間 正道, 岡田 恭穂, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 薮内 伸一, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 元井 冬彦, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　644-644　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1024. 胆嚢管が膵内胆管に合流するMirizzi症候群の1治療経験

    伊関 雅裕, 水間 正道, 吉田 寛, 阿部 友哉, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 薮内 伸一, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　660-660　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1025. 膵癌根治切除例におけるPET SUV max値と予後・再発形式の関連

    元井 冬彦, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 薮内 伸一, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　694-694　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1026. 遠位膵切除の術式と成績 尾側膵癌における術前治療(NAT)に期待される効果

    青木 修一, 水間 正道, 元井 冬彦, 岡田 良, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　395-395　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1027. 膵癌根治切除術における腹水洗浄細胞診の臨床的意義と術前治療・進行度との相関について

    岡田 恭穂, 乙供 茂, 元井 冬彦, 青木 修一, 水間 正道, 岡田 良, 川口 桂, 益田 邦洋, 深瀬 耕二, 藪内 伸一, 坂田 直昭, 大塚 英郎, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　534-534　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1028. "mesopancreas"、"mesopancreatoduodenum"及びその切除術式に関するレビュー

    石田 晶玄, 元井 冬彦, 畠 達夫, 青木 修一, 青木 豪, 岡田 良, 川口 桂, 益田 邦洋, 深瀬 耕二, 薮内 伸一, 大塚 英郎, 坂田 直昭, 水間 正道, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　27回　546-546　2015/06

    Publisher: (一社)日本肝胆膵外科学会

  1029. 肥満手術が代謝に及ぼす影響 糖尿病合併重症肥満患者に対するスリーブバイパス術の効果

    内藤 剛, 田中 直樹, 宮地 智洋, 井本 博文, 土屋 堯裕, 河野 えみ子, 長尾 宗紀, 武者 宏昭, 中川 圭, 森川 孝則, 元井 冬彦, 片寄 友, 海野 倫明

    外科と代謝・栄養　49　(3)　129-129　2015/06

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

  1030. 食事誘発性NASHモデルラットにおける十二指腸空腸バイパス手術のNASH改善効果の検討

    土屋 堯裕, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 大沼 忍, 武者 宏昭, 元井 冬彦, 内藤 剛, 海野 倫明

    外科と代謝・栄養　49　(3)　155-155　2015/06

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  1031. Sleeve保険収載1年 現状と問題点 Sleeve保険収載1年 当院での減量手術の動向と課題

    田中 直樹, 内藤 剛, 井本 博文, 宮地 智洋, 土屋 堯裕, 河野 えみ子, 長尾 宗紀, 渡辺 和宏, 澤田 正二郎, 片桐 秀樹, 岡本 智子, 武田 みゆき, 武者 宏昭, 元井 冬彦, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　51-51　2015/06

    Publisher: 日本肥満症治療学会

  1032. 病的肥満症に対する減量手術の安全性と有効性の検討

    田中 直樹, 内藤 剛, 長尾 宗紀, 井本 博文, 宮地 智洋, 土屋 堯裕, 河野 えみ子, 渡辺 和宏, 澤田 正二郎, 片桐 秀樹, 武者 宏昭, 大沼 忍, 元井 冬彦, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　33回　122-122　2015/06

    Publisher: 日本肥満症治療学会

  1033. ステージII、III進行結腸癌に対する腹腔鏡下結腸切除術

    大沼 忍, 内藤 剛, 唐澤 秀明, 青木 豪, 工藤 克昌, 佐々木 宏之, 石田 晶玄, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　68　(6)　436-436　2015/06

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1034. 内視鏡治療後に追加腸切除を施行した30症例の検討

    唐澤 秀明, 内藤 剛, 大沼 忍, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　68　(6)　472-472　2015/06

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1035. 当科におけるクローン病術後の腸管不全(短腸症候群)症例の検討

    渡辺 和宏, 長尾 宗紀, 阿部 友哉, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 生澤 史江, 土屋 堯裕, 河野 えみ子, 小野 智之, 大沼 忍, 中川 圭, 林 洋毅, 森川 孝則, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    外科と代謝・栄養　49　(3)　172-172　2015/06

    Publisher: 日本外科代謝栄養学会

    ISSN： 0389-5564

    eISSN： 2187-5154

  1036. 膵癌の発見経緯からみた切除可能症例の解析~院内がん登録と膵癌登録を用いて

    水元一博, 田中雅夫, 海野倫明, 五十嵐久人, 糸井隆夫, 江川新一, 児玉裕三, 里井壮平, 濱田晋, 水間正道

    すい臓　30　(3)　418　2015/05/18

    ISSN： 0913-0071

  1037. Soft Pancreas膵管非拡張症例の膵消化管再建 長期成績を含めて 膵空腸吻合の層別化と膵瘻率の改善に向けて

    中川 圭, 元井 冬彦, 片寄 友, 岡田 良, 川口 桂, 青木 豪, 深瀬 耕二, 水間 正道, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 海野 倫明

    膵臓　30　(3)　282-282　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1038. 後期高齢者における膵頭十二指腸切除術周術期のリスク因子の検討

    森川 孝則, 岡田 恭穂, 川口 桂, 益田 邦洋, 青木 豪, 岡田 良, 石田 昌玄, 薮内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    膵臓　30　(3)　376-376　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1039. Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus surgery-first for resectable pancreatic carcer (Prep-02/JSAP05).

    Michiaki Unno, Fuyuhiko Motoi, Tomoo Kosuge, Hideki Ueno, Hiroki Yamaue, Sohei Satoi, Masayuki Sho, Goro Honda, Ippei Matsumoto, Keita Wada, Junji Furuse, Tohru Furukawa, Kazuyuki Ishida, Kei Takase, Yutaka Matsuyama, Kei Nakagawa, Yu Katayose

    JOURNAL OF CLINICAL ONCOLOGY　33　(15)　2015/05

    ISSN： 0732-183X

    eISSN： 1527-7755

  1040. 当院で施行した膵全摘術および自家膵島移植症例の長期経過

    坂田 直昭, 後藤 昌史, 元井 冬彦, 林 洋毅, 澤田 正二郎, 中川 圭, 水間 正道, 深瀬 耕二, 五十嵐 康弘, 廣田 衛久, 岡田 恭穂, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 正宗 淳, 下瀬川 徹, 片桐 秀樹, 里見 進, 海野 倫明

    膵臓　30　(3)　383-383　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1041. 膵腫瘍術後12ヵ月での健康関連QOL尺度SF36v2による術式別検討 介入の糸口を求めて

    片寄 友, 佐藤 菜保子, 中川 圭, 森川 孝則, 吉田 寛, 林 洋毅, 岡田 恭穂, 水間 正道, 坂田 直昭, 大塚 英郎, 深瀬 耕二, 藪内 伸一, 青木 豪, 石田 晶玄, 川口 桂, 岡田 良, 益田 邦洋, 内藤 剛, 元井 冬彦, 海野 倫明

    膵臓　30　(3)　383-383　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1042. 膵癌術後転移巣に対する外科的切除の役割

    水間 正道, 元井 冬彦, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 森川 孝則, 中川 圭, 林 洋毅, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 下瀬川 徹, 海野 倫明

    膵臓　30　(3)　403-403　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1043. 【Borderline resectable膵癌の最前線-診断・治療法はどう変わったか-】 BR膵癌の切除可能性をどのように決定するか?

    元井 冬彦, 青木 修一, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 内藤 剛, 片寄 友, 海野 倫明

    胆と膵　36　(5)　435-440　2015/05

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1044. 膵癌切除における術前CRP値が予後に与える影響

    青木 修一, 水間 正道, 元井 冬彦, 岡田 良, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    膵臓　30　(3)　419-419　2015/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1045. 外科切除例からみた大腸早期癌のリンパ節転移

    大沼 忍, 内藤 剛, 唐澤 秀明, 青木 豪, 佐々木 宏之, 工藤 克昌, 田中 直樹, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　68　(5)　348-348　2015/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1046. 当科における高齢者大腸癌(75歳以上)の短期手術成績

    唐澤 秀明, 内藤 剛, 大沼 忍, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 元井 冬彦, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　68　(5)　358-358　2015/05

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1047. Randomized Clinical Trial of Duct-to-Mucosa Pancreaticogastrostomy of Pancreatic Stump Versus Hand-Sewn Closure After Distal Pancreatectomy

    Kenichiro Uemura, Sohei Satoi, Fuyuhiko Motoi, Yasushi Hashimoto, Hiroaki Yanagimoto, Koji Fukase, Naru Kondo, Tomohisa Yamamoto, Yu Katayose, A-Hon Kwon, Michiaki Unno, Yoshiaki Murakami

    GASTROENTEROLOGY　148　(4)　S1182-S1182　2015/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  1048. Serum Carbohydrate Antigen 19-9 Values After Neoadjuvant Therapy Predict Survival of Patients With Pancreatic Adenocarcinoma: A Multicenter Case-Control Study of 269 Patients

    Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Hiroki Yamaue, Ippei Matsumoto, Michiaki Unno

    GASTROENTEROLOGY　148　(4)　S1162-S1163　2015/04

    ISSN： 0016-5085

    eISSN： 1528-0012

  1049. 肥満症外科治療の現状と展望 肥満症外科治療の基礎 効果メカニズム

    土屋 堯裕, 内藤 剛, 海野 倫明

    肥満研究　21　(1)　27-35　2015/04

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1050. 切除可能膵癌に対する治療戦略 手術先行vs術前治療 肝胆膵 切除適応・切除企図膵癌の治療戦略としての術前GS療法の意義 手術先行と比較した優越性

    元井 冬彦, 岡田 良, 川口 桂, 益田 邦洋, 青木 豪, 石田 晶玄, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　PD-3　2015/04

    Publisher: (一社)日本外科学会

  1051. 肝胆膵 膵神経内分泌腫瘍外科治療におけるリンパ節郭清の適応・範囲に関する検討

    石田 晶玄, 元井 冬彦, 青木 豪, 岡田 良, 川口 桂, 益田 邦洋, 大沼 忍, 薮内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-055　2015/04

    Publisher: (一社)日本外科学会

  1052. 下部消化管 大腸癌同時性肝転移の治療 術前および術後補助療法の前向き試験からの検討

    片寄 友, 中川 圭, 及川 昌也, 山内 淳一郎, 竹村 真一, 岡田 良, 川口 桂, 益田 邦洋, 石田 晶玄, 藪内 新一, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-179　2015/04

    Publisher: (一社)日本外科学会

  1053. 肝胆膵 膵頭十二指腸切除術におけるFast-track surgery導入の取り組み

    岡田 恭穂, 元井 冬彦, 吉田 寛, 水間 正道, 林 洋毅, 中川 圭, 川口 桂, 益田 邦洋, 石田 晶玄, 岡田 良, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 森川 孝則, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-157　2015/04

    Publisher: (一社)日本外科学会

  1054. 肝胆膵 当科における残膵切除症例の検討

    益田 邦洋, 岡田 良, 川口 桂, 青木 豪, 石田 晶玄, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-159　2015/04

    Publisher: (一社)日本外科学会

  1055. 肝胆膵 胆道癌取扱い規約第6版による当科肝門部領域胆管癌手術症例の検討

    岡田 良, 水間 正道, 川口 桂, 益田 邦洋, 石田 晶玄, 薮内 伸一, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-281　2015/04

    Publisher: (一社)日本外科学会

  1056. 肝胆膵 肝外胆管癌再発における外科的切除の治療成績

    水間 正道, 林 洋毅, 吉田 寛, 川口 桂, 益田 邦洋, 石田 晶玄, 岡田 良, 深瀬 耕二, 藪内 伸一, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-281　2015/04

    Publisher: (一社)日本外科学会

  1057. 胆道癌に対するMajor HPD(肝葉切除+膵頭十二指腸切除)の適応と限界 肝胆膵 胆道癌に対するMajor HPDの適応と限界

    林 洋毅, 吉田 寛, 森川 孝則, 中川 圭, 岡田 恭穂, 水間 正道, 大塚 英郎, 坂田 直昭, 深瀬 耕二, 藪内 伸一, 石田 晶玄, 青木 豪, 益田 邦洋, 川口 桂, 岡田 良, 内藤 剛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　PD-21　2015/04

    Publisher: (一社)日本外科学会

  1058. 肝胆膵 Borderline resectable膵癌に対する膵頭十二指腸切除 R0切除を目的とした後腹膜・神経叢一括郭清

    深瀬 耕二, 川口 桂, 益田 邦洋, 岡田 良, 石田 晶玄, 藪内 伸一, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 岡田 恭穂, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-271　2015/04

    Publisher: (一社)日本外科学会

  1059. その他 SF36v2を用いた膵切除後のQOL評価

    川口 桂, 片寄 友, 佐藤 菜保子, 益田 邦洋, 岡田 良, 石田 晶玄, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 中川 圭, 岡田 恭穂, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-244　2015/04

    Publisher: (一社)日本外科学会

  1060. 肝胆膵 細胞外基質と血管新生因子が筋肉内膵島移植に与える有効性の検討

    土屋 朗之, 坂田 直昭, 吉松 軍平, 青木 豪, 川口 桂, 益田 邦洋, 岡田 良, 石田 晶玄, 薮内 伸一, 深瀬 耕二, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-272　2015/04

    Publisher: (一社)日本外科学会

  1061. 肝胆膵 膵島移植生着を評価するための画像検査 超音波検査の可能性について

    坂田 直昭, 小玉 哲也, 吉松 軍平, 青木 豪, 石田 晶玄, 川口 桂, 益田 邦洋, 岡田 良, 薮内 伸一, 深瀬 耕二, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-272　2015/04

    Publisher: (一社)日本外科学会

  1062. 肝胆膵 規約改訂により中・下部胆管癌を区別せず遠位胆管癌として統一することの注意点

    青木 修一, 水間 正道, 吉田 寛, 岡田 良, 阿部 友哉, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-068　2015/04

    Publisher: (一社)日本外科学会

  1063. 肝胆膵 難治性肝嚢胞性疾患に対する腹腔鏡下手術 ICG蛍光法の有用性

    森川 孝則, 岡田 良, 川口 桂, 青木 豪, 益田 邦洋, 石田 昌玄, 大沼 忍, 薮内 伸一, 深瀬 耕二, 大塚 英郎, 水間 正道, 坂田 直昭, 武者 宏昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-276　2015/04

    Publisher: (一社)日本外科学会

  1064. 下部消化管 骨盤内臓全摘術後の尿路再建法

    大沼 忍, 内藤 剛, 工藤 克昌, 石田 晶玄, 木村 俊一, 唐澤 秀明, 青木 豪, 佐々木 宏之, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 岡田 恭穂, 林 洋毅, 武者 宏昭, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-175　2015/04

    Publisher: (一社)日本外科学会

  1065. その他 研修医に対する動物を用いた消化器外科トレーニングの効果

    工藤 克昌, 野田 雅史, 藪内 伸一, 水間 正道, 武者 宏昭, 田中 直樹, 大沼 忍, 石田 晶玄, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 青木 豪, 唐澤 秀明, 佐々木 宏之, 森川 孝則, 中川 圭, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-252　2015/04

    Publisher: (一社)日本外科学会

  1066. 上部消化管 Runx1 +24mCNEトランスジェニックマウスを用いたLineage tracing(細胞系譜追跡法)によるマウス胃体部幹細胞の探索および解析

    木村 俊一, 松尾 純一, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 川口 桂, 唐澤 秀明, 青木 豪, 大沼 忍, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 内藤 剛, 伊藤 嘉明, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　YIA-3　2015/04

    Publisher: (一社)日本外科学会

  1067. 下部消化管 潰瘍性大腸炎における大腸全摘・回腸嚢肛門吻合術術後の排便状況および生活の質についての横断的・縦断的検討

    渡辺 和宏, 内藤 剛, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 田中 直樹, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 生澤 史江, 木村 俊一, 宮地 智洋, 土屋 堯裕, 小林 実, 森川 孝則, 中川 圭, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-191　2015/04

    Publisher: (一社)日本外科学会

  1068. 下部消化管 当科における小児潰瘍性大腸炎手術例の検討

    長尾 宗紀, 渡辺 和宏, 田中 直樹, 阿部 友哉, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 武者 宏昭, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本外科学会定期学術集会抄録集　115回　OP-191　2015/04

    Publisher: (一社)日本外科学会

  1069. 生活習慣病・メタボリックシンドロームと消化器疾患 病態と治療 高度肥満糖尿病患者における十二指腸空腸バイパス術の糖尿病改善効果

    内藤 剛, 田中 直樹, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A177-A177　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1070. 【膵癌・胆道癌-基礎と臨床の最新研究動向-】 胆道癌 腺癌 胆嚢癌 予後 胆嚢癌の治療成績 日本と欧米の比較

    大塚 英郎, 林, 洋毅, 海野 倫明

    日本臨床　73　(増刊3 膵癌・胆道癌)　605-609　2015/03

  1071. 【膵癌・胆道癌-基礎と臨床の最新研究動向-】 胆道癌 腺癌 胆嚢癌 治療 外科的切除(適応・術式) 胆嚢癌に対する手術適応と術式選択 開腹手術

    吉田 寛, 林, 洋毅, 片寄, 友, 海野 倫明

    日本臨床　73　(増刊3 膵癌・胆道癌)　576-579　2015/03

  1072. 【膵癌・胆道癌-基礎と臨床の最新研究動向-】 胆道癌 腺癌 胆嚢癌 治療 胆嚢癌 治療のアルゴリズム

    片寄 友, 林, 洋毅, 海野 倫明

    日本臨床　73　(増刊3 膵癌・胆道癌)　572-575　2015/03

  1073. 筋肉内膵島移植を成功させるための戦略 細胞外基質と成長因子の有効性と超音波検査による移植膵島のモニタリング

    坂田 直昭, 土屋 朗之, 青木 豪, 石田 晶玄, 益田 邦洋, 岡田 良, 藪内 伸一, 深瀬 耕二, 大塚 英郎, 水間 正道, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A437-A437　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1074. [Laparoscopic surgery for pancreatic cancer]. Peer-reviewed

    Morikawa T, Naitoh T, Unno M

    Nihon rinsho. Japanese journal of clinical medicine　73 Suppl 3　134-137　2015/03

    ISSN： 0047-1852

  1075. 【膵癌・胆道癌-基礎と臨床の最新研究動向-】 膵癌 上皮性腫瘍 通常型膵癌 治療 外科的切除 標準的切除 膵癌に対する腹腔鏡下手術

    森川 孝則, 内藤 剛, 海野 倫明

    日本臨床　73　(増刊3 膵癌・胆道癌)　134-137　2015/03

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  1076. 【炎症性腸疾患外科治療の最近の動向】 Crohn病腸管病変に対する外科治療

    舟山 裕士, 鈴木 秀幸, 高橋 賢一, 羽根田 祥, 渡辺 和宏, 生澤 史江, 海野 倫明

    日本外科学会雑誌　116　(2)　94-98　2015/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1077. 胃癌の歴史 発展期 幽門保存胃切除(PPG)開発の経緯と胃癌への応用

    柴田 近, 武者 宏昭, 田中 直樹, 工藤 克昌, 内藤 剛, 海野 倫明, 佐々木 巖

    日本胃癌学会総会記事　87回　162-162　2015/03

    Publisher: (一社)日本胃癌学会

  1078. 逆流防止弁形成食道残胃吻合腹腔鏡補助下噴門側胃切除術の手技および治療成績

    武者 宏昭, 青木 豪, 工藤 克昌, 田中 直樹, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本胃癌学会総会記事　87回　326-326　2015/03

    Publisher: (一社)日本胃癌学会

  1079. 食事誘発性NASHモデルラットにおける十二指腸空腸バイパス手術のNASH改善効果の検討

    土屋 堯裕, 長尾 宗紀, 田中 直樹, 渡辺 和宏, 宮地 智洋, 河野 えみ子, 小野 智之, 岡田 恭穂, 林 洋毅, 坂田 直昭, 大沼 忍, 森川 孝則, 中川 圭, 武者 宏昭, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A454-A454　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1080. 局所進行胃癌に対するTS-1+weekly CDDP併用術前化学療法の第2相臨床試験

    田中 直樹, 武者 宏昭, 工藤 克昌, 青木 豪, 木内 誠, 大沼 忍, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 片寄 友, 元井 冬彦, 柴田 近, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　87回　449-449　2015/03

    Publisher: (一社)日本胃癌学会

  1081. 大腸癌に発現する抗癌剤耐性ABCトランスポーターのスプライスバリアント解析

    小林 実, 大沼 忍, 唐澤 秀明, 青木 豪, 工藤 克昌, 石田 晶玄, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 森川 孝則, 武者 宏昭, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A367-A367　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1082. クローン病の腸管不全症例に対する包括的な管理法の確立に向けた当科での取り組み

    渡辺 和宏, 内藤 剛, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 田中 直樹, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 生澤 史江, 木村 俊一, 宮地 智洋, 土屋 堯裕, 森川 孝則, 中川 圭, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A385-A385　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1083. 当科における小児期発症潰瘍性大腸炎手術例の検討

    長尾 宗紀, 渡辺 和宏, 田中 直樹, 阿部 友哉, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 武者 宏昭, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A386-A386　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1084. Pagetoid spreadを伴う肛門管癌4切除例の検討

    小原 恵, 大沼 忍, 唐澤 秀明, 青木 豪, 石田 晶玄, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　112　(臨増総会)　A501-A501　2015/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1085. 腹腔鏡下に切除し得た小腸Dieulafoy lesionの1例

    盛 彬子, 大塚 英郎, 川口 桂, 益田 邦洋, 深瀬 耕二, 森川 孝則, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　35　(2)　432-432　2015/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1086. 移植膵島の生着を評価するための超音波検査研究のこれまでの足取り

    坂田直昭, NICOLAS Sax, 青木豪, 石田晶玄, 片寄友, 江川新一, 小玉哲也, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　42nd　76　2015/02

  1087. 細胞外基質と成長因子の処置により筋肉内膵島移植の移植効果は劇的に向上する

    坂田直昭, 土屋朗之, 青木豪, 石田晶玄, 川口桂, 益田邦洋, 岡田良, 薮内伸一, 深瀬耕二, 大塚英郎, 水間正道, 岡田恭穂, 林洋毅, 中川圭, 森川孝則, 吉田寛, 元井冬彦, 片寄友, 江川新一, 海野倫明

    再生医療　14　249　2015/02/01

    ISSN： 1347-7919

  1088. 腹腔鏡下幽門側胃切除術を行った胃glomus腫瘍の1例

    土屋 堯裕, 青木 豪, 武者 宏昭, 長尾 宗紀, 伊東 賢, 笠島 敦子, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　76　(2)　279-285　2015/02

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.76.279 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  1089. 原発性進行大腸癌に対する骨盤内臓全摘術の有用性と問題点

    戸嶋 政秀, 大沼 忍, 武者 宏昭, 森川 孝則, 阿部 友哉, 長尾 宗紀, 田中 直樹, 羽根田 祥, 工藤 克昌, 青木 豪, 梶原 大輝, 小村 俊博, 松田 泰史, 染谷 崇徳, 宮地 智洋, 内藤 剛, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　68　(2)　131-131　2015/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1090. 直腸神経内分泌腫瘍に対する治療方針の検討

    神山 篤史, 大沼 忍, 阿部 友哉, 長尾 宗紀, 武者 宏昭, 羽根田 祥, 工藤 克昌, 森川 孝則, 片寄 友, 江川 新一, 笠島 敦子, 海野 倫明

    日本大腸肛門病学会雑誌　68　(2)　139-139　2015/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1091. TG07およびTG13からみた当科の急性胆嚢炎治療の検討 院内発生例を中心に

    阿部 友哉, 内藤 剛, 水間 正道, 大沼 忍, 武者 宏昭, 中川 圭, 岡田 恭穂, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　35　(2)　418-418　2015/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1092. 消化管ステント挿入後、頻回の下痢により低カリウム血症をきたし心停止に陥った直腸癌イレウスの1例

    小原 恵, 大沼 忍, 工藤 克昌, 石田 晶玄, 唐澤 秀明, 青木 豪, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 杉沢 徳彦, 小林 実, 武者 宏昭, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本腹部救急医学会雑誌　35　(2)　471-471　2015/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

    eISSN： 1882-4781

  1093. 膵腫瘍患者の手術後6ヵ月までのQOLに関する縦断研究

    佐藤 菜保子, 片寄 友, 元井 冬彦, 中川 圭, 川口 桂, 海野 倫明, 佐藤 冨美子

    日本がん看護学会誌　29　(Suppl.)　193-193　2015/01

    Publisher: (一社)日本がん看護学会

    ISSN： 0914-6423

  1094. Neoadjuvant chemoradiation therapy for cholangiocarcinoma to improve R0 resection rate: The first report of phase II study.

    Yu Katayose, Kei Nakagawa, Hiroshi Yoshida, Takanori Morikawa, Hiroki Hayashi, Takaho Okada, Masamichi Mizuma, Naoaki Sakata, Hideo Ohtsuka, Koji Fukase, Shinichi Yabuuchi, Masaharu Ishida, Takeshi Aoki, Ryo Okada, Kunihiro Masuda, Kei Kawaguchi, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

    JOURNAL OF CLINICAL ONCOLOGY　33　(3)　2015/01

    ISSN： 0732-183X

    eISSN： 1527-7755

  1095. The oncologic impact of pancreatic fistula after pancreatectomy in patients with pancreatic cancer

    Manabu Kawai, Yoshiaki Murakami, Seiko Hirono, Ken-Ichi Okada, Fuyuhiko Motoi, Michiaki Unno, Masayuki Sho, Yoshiyuki Nakajima, Kenichiro Uemura, Sohei Satoi, A-Hon Kwon, Ippei Matsumoto, Sadaki Asari, Goro Honda, Masanao Kurata, Hiroki Yamaue

    JOURNAL OF CLINICAL ONCOLOGY　33　(3)　2015/01

    ISSN： 0732-183X

    eISSN： 1527-7755

  1096. Improvement of Intramuscular Islet Transplantation By Mesenchymal Stem Cells and Growth Factor-Containing Scaffold

    Gumpei Yoshimatsu, Naoaki Sakata, Haruyuki Tsuchiya, Morihito Takita, Marlon Levy, Bashoo Naziruddin, Michiaki Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　15　110-110　2015/01

    ISSN： 1600-6135

    eISSN： 1600-6143

  1097. Bismuth classification is associated with the requirement for multiple biliary drainage in preoperative patients with malignant perihilar biliary stricture

    Miura S, Kanno A, Masamune A, Hamada S, Takikawa T, Nakano E, Yoshida N, Hongo S, Kikuta K, Kume K, Hirota M, Yoshida H, Katayose Y, Unno M, Shimosegawa T

    Surg Endosc　2015

    DOI： 10.1007/s00464-014-3878-y 　

  1098. Annual Report of National Clinical Database in Gastroenterological Surgery 2014

    若林剛, 今野弘之, 宇田川晴司, 海野倫明, 遠藤格, 國崎主税, 武冨紹信, 丹黒章, 橋本英樹, 正木忠彦, 本村昇, 吉田和弘, 渡邉聡明, 宮田裕章, 宮田裕章, 神谷欣志, 平原憲道, 後藤満一, 森正樹

    日本消化器外科学会雑誌(Web)　48　(12)　1032-1044 (J-STAGE)　2015

    DOI： 10.5833/jjgs.2015.sr002 　

    ISSN： 1348-9372

  1099. 前向き比較試験の適格条件で解析した,切除可能・切除企図膵癌に対する術前GS療法の有効性

    元井冬彦, 岡田良, 川口桂, 益田邦洋, 青木豪, 石田晶玄, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 中川圭, 岡田恭穂, 内藤剛, 片寄友, 片寄友, 江川新一, 海野倫明, 海野倫明

    日本消化器病学会大会(Web)　57th　GEP‐264 (WEB ONLY)　2015

  1100. 【膵癌・胆道癌-基礎と臨床の最新研究動向-】 胆道癌 腺癌 胆嚢癌 予後 長期生存に関わる予後因子

    林 洋毅, 海野 倫明

    日本臨床　73巻　(増刊3 膵癌・胆道癌)　610-614　2015

  1101. 膵外分泌機能不全動物モデルの作成

    石田 晶玄, 坂田 直昭, 工藤 克昌, 小原 恵, 小林 実, 大沼 忍, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　30　(1)　446-446　2015/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  1102. 膵頭十二指腸切除術後の膵液量は、術後脂肪肝発症の有効な予測因子である

    小原 恵, 石田 晶玄, 盛 彬子, 志村 光広, 小林 実, 工藤 克昌, 大沼 忍, 長尾 宗紀, 中川 圭, 柴田 近, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　30　(1)　592-592　2015/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  1103. ストーマ周囲のメッシュに感染し、膿瘍形成したクローン病の1例

    羽根田 祥, 長尾 宗紀, 渡辺 和宏, 高橋 真紀, 伊藤 由美, 高橋 賢一, 西條 文人, 松本 正孝, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　31　(1)　68-68　2015/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  1104. 胃癌手術周術期の体重変化の検討

    工藤 克昌, 大沼 忍, 石田 晶玄, 小林 実, 小原 恵, 長尾 宗紀, 渡辺 和宏, 盛 彬子, 志村 充広, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　30　(1)　408-408　2015/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  1105. Strategy of symptom-targeted intervention based on patient quality of life at three months after pancreatectomy

    SATO Naoko, KATAYOSE Yu, MOTOI Fuyuhiko, NAKAGAWA Kei, SAKATA Naoaki, KAWAGUCHI Kei, SATO Fumiko, UNNO Michiaki

    Journal of the Japan Pancreas Society　30　(5)　654-662　2015

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.30.654 　

    ISSN： 0913-0071

    More details Close

    Background: Surgery is the only treatment that is expected to cure pancreatic cancer but is very invasive. It usually causes severe stress in patients and may cause pain and deterioration of quality of life (QOL). Aim: To determine the level of health-related QOL (HRQOL) and symptoms of pancreatic cancer patients 3 months after surgical intervention. Materials and Methods: We statistically evaluated the correlation between the Short Form 36 Health Survey version 2 (SF-36&lt;sub&gt;v2&lt;/sub&gt;), a scale of HRQOL, and specific symptoms of hepatobiliary and pancreatic cancer using data acquired from 33 postoperative pancreatic cancer patients. Results: Deterioration of QOL was seen in many parameters of SF-36&lt;sub&gt;v2&lt;/sub&gt; at 3 months postoperatively. In particular, significant impairments of QOL at 3 months postoperatively were observed for physical functioning, vitality, physical role functioning and emotional role functioning in patients who underwent subtotal stomach-preserving pancreatoduodenectomy. Our data also revealed that appetite loss, general fatigue, discomfort or pain in the stomach area and discontent with change in appearance correlated with QOL deterioration. Conclusion: QOL can be improved by a combination of treatments for symptoms related to digestion and absorption, management of nutrition and treatment for subjective symptoms including fatigue.

  1106. A case of successful treatment with radiotherapy of hepatocellular carcinoma with portal vein tumor thrombus in secondary hemochromatosis due to myelodysplastic syndrome (2nd report)

    Koetsu Inoue, Masamichi Mizuma, Hideo Ohtsuka, Kei Nakagawa, Hiroki Hayashi, Takaho Okada, Hiroshi Yoshida, Fuyuhiko Motoi, Takeshi Naito, Yu Katayose, Keiichi Jingu, Michiaki Unno

    Acta Hepatologica Japonica　56　(4)　150-156　2015/01/01

    Publisher: 一般社団法人 日本肝臓学会

    DOI： 10.2957/kanzo.56.150 　

    ISSN： 0451-4203

  1107. いわゆる病態別経腸栄養剤にエビデンスはあるのか? 全身性炎症反応(SIR)の亢進は膵癌切除例の予後因子である 術前高EPA製剤投与による治療効果の可能性

    青木 修一, 元井 冬彦, 石田 晶玄, 工藤 克昌, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 中川 圭, 海野 倫明

    日本静脈経腸栄養学会雑誌　30　(1)　240-240　2015/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  1108. クローン病の腸管不全(IF)例における在宅中心静脈栄養(HPN)の現状と問題点

    渡辺 和宏, 長尾 宗紀, 工藤 克昌, 大沼 忍, 石田 晶玄, 小林 実, 青木 修一, 小原 恵, 盛 彬子, 志村 充広, 中川 圭, 元井 冬彦, 海野 倫明

    日本静脈経腸栄養学会雑誌　30　(1)　424-424　2015/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 2189-0161

  1109. Notch signaling is related to extrahepatic cholangiocarcinoma and a potential therapeutic target

    AOKI Shuichi, MIZUMA Masamichi, TAKAHASHI Yayoi, HAJI Yoichi, OKADA Ryo, ABE Tomoya, KARASAWA Hideaki, HAYASHI Hiroki, MOTOI Fuyuhiko, KATAYOSE Yu, TAMAI Keiichi, ISHII Naoto, UNNO Michiaki

    日本癌学会学術総会抄録集(Web)　74th　J‐1214 (WEB ONLY)　2015

  1110. 当科におけるストーマ閉鎖時の機能的端々吻合と手縫い吻合との比較検討

    長尾 宗紀, 渡辺 和宏, 工藤 克昌, 阿部 友哉, 大沼 忍, 唐澤 秀明, 伊藤 由美, 高橋 真紀, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　31　(1)　79-79　2015/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  1111. 【外科領域のpros and cons】 胃上部早期胃癌に対する術式選択 噴門側胃切除 腹腔鏡補助下噴門側胃切除(逆流防止弁形成食道残胃吻合)の治療成績

    武者 宏昭, 徳村 弘実, 海野 倫明

    外科　76　(13)　1565-1569　2014/12

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1112. 外科切除適応の境界領域―Borderline resectable cancerへの対応 がん種別の治療指針 NET Borderline resectabilityとは?

    青木豪, 海野倫明

    臨床外科　69　(12)　1376-1379　2014/11/20

    DOI： 10.11477/mf.1407200118 　

    ISSN： 0386-9857

  1113. Treatment Strategy for Colorectal Cancer with Resectable Synchronous Liver Metastases

    中川圭, 片寄友, 及川昌也, 山内淳一郎, 島村弘宗, 山本久二治, 高橋賢一, 児玉英謙, 高橋道長, 遠藤公人, 元井冬彦, 三浦康, 柴田近, 江川新一, 海野倫明

    癌の臨床　60　(5)　475-480　2014/11/17

    ISSN： 0021-4949

  1114. A report of 4 cases of Trousseau's syndrome during postoperative chemotherapy for pancreatic adenocarcinoma

    Takashi Hirosawa, Hiroki Hayashi, Naoaki Sakata, Masaharu Ishida, Koji Fukase, Shinichi Yabuuchi, Hideo Ohtsuka, Masamichi Mizuma, Takaho Okada, Kei Nakagawa, Takanori Morikawa, Hiroshi Yoshida, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　29　36-36　2014/11

    ISSN： 0815-9319

    eISSN： 1440-1746

  1115. Chemical thromboprophylaxis is safe and decreases the risk of pulmonary embolism after hepatobiliary-pancreatic surgery

    Hiroki Hayashi, Takanori Morikawa, Hiroshi Yoshida, Kei Nakagawa, Takaho Okada, Masamichi Mizuma, Koji Fukase, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　29　272-272　2014/11

    ISSN： 0815-9319

    eISSN： 1440-1746

  1116. Quantitative Targeted Proteomics in Pancreatic Cancer: Combination of Enzyme and Efflux Transporter Protein Expression are New Indicators for Gemcitabine Sensitivity

    K. Kawaguchi, F. Motoi, K. Fukase, Y. Katayose, M. Unno

    PANCREAS　43　(8)　1375-1376　2014/11

    ISSN： 0885-3177

    eISSN： 1536-4828

  1117. Quality of Life (QOL) Evaluation for Pancreatic Tumor Surgery Patients at the Three and Six Months After Surgery in a Single Center

    Y. Katayose, N. Sato, F. Motoi, K. Nakagawa, H. Yoshida, T. Morikawa, H. Hayashi, M. Mizuma, K. Fukase, T. Aoki, K. Kawaguchi, T. Naitoh, M. Unno

    PANCREAS　43　(8)　1375-1375　2014/11

    ISSN： 0885-3177

    eISSN： 1536-4828

  1118. Surgical Resection for Initially Unresectable Pancreatic Cancer After Preoperative Therapy

    K. Fukase, F. Motoi, Y. Katayose, M. Unno

    PANCREAS　43　(8)　1358-1358　2014/11

    ISSN： 0885-3177

    eISSN： 1536-4828

  1119. 当科での中心静脈ポート感染に対する抗生剤ロック療法の現状

    阿部 友哉, 羽根田 祥, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 水間 正道, 大沼 忍, 武者 宏昭, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本外科感染症学会雑誌　11　(5)　571-571　2014/11

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  1120. 進行胆嚢癌術後の縦隔転移に対する集学的治療が奏効した1例

    片桐 宗利, 片寄 友, 藪内 伸一, 唐澤 秀明, 佐藤 純, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    癌と化学療法　41　(12)　1527-1529　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1121. S-1併用術前化学放射線療法により側方リンパ節転移が消失したと考えられた直腸癌の1例

    木村 俊一, 大沼 忍, 唐澤 秀明, 青木 豪, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    癌と化学療法　41　(12)　1560-1562　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1122. 長期間に及ぶ化学療法により組織学的CRが得られた局所進行直腸癌の1例

    小林 実, 大沼 忍, 加藤 俊介, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 渡辺 和宏, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    癌と化学療法　41　(12)　1755-1757　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1123. 術後8年で局所・遠隔転移再発を認めた通常型膵癌の1例

    谷口 肇, 水間 正道, 元井 冬彦, 阿部 友哉, 岡田 良, 川口 桂, 唐澤 秀明, 益田 邦洋, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    癌と化学療法　41　(12)　2193-2195　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1124. 術前S-1+CDDP分割投与によりpCRが得られた進行胃癌の2例

    河野 えみ子, 田中 直樹, 工藤 克昌, 武者 宏昭, 土屋 堯裕, 宮地 智洋, 長尾 宗紀, 梶原 大輝, 木村 俊一, 唐澤 秀明, 青木 豪, 阿部 友哉, 大沼 忍, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    癌と化学療法　41　(12)　2279-2281　2014/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1125. 膵手術における創感染リスク因子の検討

    水間正道, 岡田良, 阿部友哉, 大塚英郎, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 吉田寛, 内藤剛, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　75　582　2014/10/20

    ISSN： 1345-2843

  1126. 切除企図膵癌に対する術前化学療法の標準化に向けて

    川口 桂, 元井 冬彦, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　377-377　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1127. 胆道癌における切除断端陽性時の対応 肝門部領域胆管癌症例における断端陽性の検討

    益田 邦洋, 吉田 寛, 薮内 伸一, 深瀬 耕二, 水間 正道, 大塚 英郎, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 岡田 恭穂, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　312-312　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1128. 大腸癌多発肝転移に対する術前化学療法の周術期合併症と治療成績の検討

    大塚 英郎, 片寄 友, 益田 邦洋, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 岡田 高穂, 吉田 寛, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　417-417　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1129. 超高齢者に発症した肝血管腫自然破裂の1救命例

    志村 充広, 水間 正道, 岡田 良, 阿部 友哉, 谷口 肇, 岡田 恭穂, 益田 邦洋, 深瀬 耕二, 元井 冬彦, 内藤 剛, 片寄 友, 高瀬 圭, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　482-482　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1130. 膵癌手術における腹腔洗浄細胞診の臨床的意義について

    岡田 恭穂, 乙供 茂, 元井 冬彦, 水間 正道, 中川 圭, 林 洋毅, 岡田 良, 深瀬 耕二, 益田 邦洋, 藪内 伸一, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　580-580　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1131. A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms changes mucin gene expression and gene expression profiles

    Hirotake Komatsu, Naoaki Sakata, Takeshi Aoki, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Toru Furukawa

    CANCER RESEARCH　74　(19)　2014/10

    DOI： 10.1158/1538-7445.AM2014-4407 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1132. p62/sequestosome 1, a potent prognostic factor, enhance cell proliferation in human colorectal carcinoma

    Shun Nakayama, Takashi Suzuki, Shinichi Yabuuchi, Kiyoshi Takagi, Yoshiaki Onodera, Yasuhiro Nakamura, Mika Watanabe, Fumiyoshi Fujishima, Hiroshi Yoshida, Takanori Morikawa, Hideaki Karasawa, Tomohiko Sase, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno, Hironobu Sasano

    CANCER RESEARCH　74　(19)　2014/10

    DOI： 10.1158/1538-7445.AM2014-4733 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1133. TO ESTABLISH NEOADJUVANT CHEMOTHERAPY FOR PANCREATIC CANCER AS A STANDARD TREATMENT

    Fuyuhiko Motoi, Michiaki Unno

    ANNALS OF ONCOLOGY　25　2014/10

    DOI： 10.1093/annonc/mdu424.2 　

    ISSN： 0923-7534

    eISSN： 1569-8041

  1134. IFI27 and NOV, downstream regulated genes by S100A4, are playing important roles in pancreatic carcinogenesis

    Na Chen, Yuriko Saiki, Hitoshi Sekine, Makoto Sunamura, Shinichi Fukushige, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii

    CANCER RESEARCH　74　(19)　2014/10

    DOI： 10.1158/1538-7445.AM2014-4993 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1135. 求められる臨床研究の基盤 臨床研究の推進に必要な環境整備

    中川 圭, 内藤 剛, 畠 達夫, 青木 豪, 工藤 克昌, 大沼 忍, 渡辺 和宏, 深瀬 耕二, 田中 直樹, 阿部 友哉, 林 洋毅, 森川 孝則, 吉田 寛, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　379-379　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1136. 腹腔鏡下脾臓摘出術におけるLeGEART法の試み

    青木 豪, 森川 孝則, 工藤 克昌, 大沼 忍, 渡辺 和宏, 田中 直樹, 阿部 友哉, 林 洋毅, 吉田 寛, 片寄 友, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　649-649　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1137. 術前膵瘻リスク評価における膵実質ADC値の有用性

    青木 修一, 水間 正道, 岡田 良, 阿部 友哉, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　440-440　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1138. PNETの新展開 Well-differentiated endocrine carcinoma(WDEC)はNECより区別されるべき病態である

    青木 豪, 坂田 直昭, 大沼 忍, 大塚 英郎, 林 洋毅, 中川 圭, 武者 宏昭, 森川 孝則, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　313-313　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1139. 同時性肝転移を有する進行結腸・直腸癌に対する、原発巣切除先行・化学療法後肝切除戦略

    石田 晶玄, 片寄 友, 山内 淳一郎, 及川 昌也, 武者 宏昭, 島村 弘宗, 三浦 康, 桜井 直樹, 中川 圭, 林 洋毅, 森川 孝則, 岡田 恭穂, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　417-417　2014/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.75.S417 　

    ISSN： 1345-2843

  1140. ガイドラインに基づく胃NEN治療の実際

    橘 知睦, 青木 豪, 吉田 寛, 中川 圭, 岡田 恭穂, 林 洋毅, 森川 孝則, 武者 宏昭, 坂田 直昭, 大沼 忍, 田中 直樹, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　505-505　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1141. 肝胆膵領域の腹腔鏡下手術において拡大視効果は何をもたらしたのか 拡大視効果が膵臓内視鏡外科にもたらしたものとは?

    森川 孝則, 内藤 剛, 青木 豪, 武者 宏昭, 阿部 友哉, 大沼 忍, 田中 直樹, 工藤 克昌, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　324-324　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1142. 膵内視鏡外科の安全性と効率化 新しい術野展開法Stomach roll-up technique 腹腔鏡下膵体尾部切除術の安全性向上・定型化を目指して

    森川 孝則, 内藤 剛, 青木 豪, 阿部 友哉, 武者 宏昭, 大沼 忍, 田中 直樹, 工藤 克昌, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　399-399　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1143. 炎症性腸疾患に対する腹腔鏡下手術 成績と今後の展望 重症潰瘍性大腸炎における用手補助腹腔鏡下(HALS)大腸亜全摘術のエビデンス

    渡辺 和宏, 内藤 剛, 武者 宏昭, 森川 孝則, 阿部 友哉, 長尾 宗紀, 田中 直樹, 大沼 忍, 工藤 克昌, 青木 豪, 宮地 智洋, 土屋 堯裕, 河野 えみ子, 高橋 賢一, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　419-419　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1144. 当科における潰瘍性大腸炎に対する腹腔鏡下手術手技と成績

    阿部 友哉, 内藤 剛, 長尾 宗紀, 渡辺 和宏, 大沼 忍, 森川 孝則, 武者 宏昭, 田中 直樹, 青木 豪, 林 洋毅, 吉田 寛, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　528-528　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1145. 腹腔鏡下肥満外科手術の現状と展望

    田中 直樹, 内藤 剛, 長尾 宗紀, 渡辺 和宏, 宮地 智洋, 土屋 堯裕, 河野 えみ子, 小野 智之, 森川 孝則, 武者 宏昭, 大沼 忍, 阿部 友哉, 工藤 克昌, 青木 豪, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　703-703　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

    eISSN： 2186-6643

  1146. FDG-PETで発見され悪性腫瘍との鑑別が困難であった硬化性腸間膜炎の1例

    佐瀬 友彦, 唐澤 秀明, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(10)　2779-2782　2014/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.75.2779 　

    ISSN： 1345-2843

  1147. 局所再発直腸癌に対する治療戦略

    大沼 忍, 内藤 剛, 木村 俊一, 唐澤 秀明, 青木 豪, 工藤 克昌, 佐々木 宏之, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　322-322　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1148. 腹腔鏡下幽門側胃切除におけるpitfallとリンパ節廓清の工夫

    武者 宏昭, 唐澤 秀明, 青木 豪, 工藤 克昌, 大沼 忍, 渡辺 和宏, 長尾 宗紀, 田中 直樹, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　353-353　2014/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.75.353 　

    ISSN： 1345-2843

  1149. 巨大直腸GISTの治療戦略

    木村 俊一, 大沼 忍, 唐澤 秀明, 青木 豪, 佐々木 宏之, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　410-410　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1150. 胆嚢癌術後縦隔転移再発巣に対して外科治療が奏効した1例

    片桐 宗利, 片寄 友, 藪内 伸一, 唐澤 秀明, 大塚 英郎, 水間 正道, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　557-557　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1151. 巨大リンパ節転移を伴う胆嚢癌を化学療法後に切除した1例

    竹浪 努, 中川 圭, 藪内 伸一, 唐澤 秀明, 深瀬 耕二, 水間 正道, 坂田 直昭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　557-557　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1152. 当科における慢性偽性腸閉塞症手術例4例の検討

    長尾 宗紀, 渡辺 和宏, 田中 直樹, 阿部 友哉, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 柴田 近, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　574-574　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1153. 胃癌手術症例における術後体重変化

    工藤 克昌, 武者 宏昭, 田中 直樹, 青木 豪, 大沼 忍, 石田 晶玄, 阿部 友哉, 長尾 宗紀, 渡辺 和宏, 唐澤 秀明, 木村 俊一, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　626-626　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1154. 狭窄症状を伴う切除不能進行胃癌に対する緩和手術

    杉沢 徳彦, 渡辺 和宏, 大沼 忍, 武者 宏昭, 阿部 友哉, 長尾 宗紀, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 戸嶋 政秀, 高見 一弘, 高橋 良延, 内藤 剛, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　627-627　2014/10

    Publisher: 日本臨床外科学会

    DOI： 10.3919/jjsa.75.627 　

    ISSN： 1345-2843

    eISSN： 1882-5133

  1155. 狭窄症状を伴う切除不能大腸癌に対する緩和手術の成績

    渡辺 和宏, 内藤 剛, 武者 宏昭, 阿部 友哉, 長尾 宗紀, 田中 直樹, 大沼 忍, 工藤 克昌, 青木 豪, 唐澤 秀明, 高橋 良延, 高見 一弘, 戸嶋 政秀, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　75　(増刊)　628-628　2014/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1156. 肥満と癌 減量手術と悪性腫瘍

    内藤 剛, 田中 直樹, 長尾 宗紀, 宮地 智洋, 土屋 堯裕, 唐澤 秀明, 佐々木 宏之, 工藤 克昌, 大沼 忍, 渡辺 和宏, 阿部 友哉, 武者 宏昭, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    肥満研究　20　(Suppl.)　117-117　2014/10

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1157. Metabolic Surgery 適応と今後の展望 減量手術の糖尿病改善効果

    内藤 剛, 田中 直樹, 森川 孝則, 武者 宏昭, 阿部 友哉, 長尾 宗紀, 大沼 忍, 渡辺 和宏, 工藤 克昌, 青木 豪, 唐澤 秀明, 宮地 智洋, 土屋 堯裕, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　387-387　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1158. LDGにおける術野展開の工夫

    武者 宏昭, 唐澤 秀明, 青木 豪, 工藤 克昌, 大沼 忍, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　626-626　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1159. ステージII、III結腸癌に対する腹腔鏡下結腸切除術

    大沼 忍, 内藤 剛, 阿部 友哉, 唐澤 秀明, 青木 豪, 佐々木 宏之, 工藤 克昌, 渡辺 和宏, 田中 直樹, 長尾 宗紀, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　19　(7)　755-755　2014/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1160. MK2461は膵癌細胞と癌関連線維芽細胞の相互作用を制御し膵癌増殖を抑制する(MK2461 regulated proliferation of pancreatic cancer disrupting interaction between pancreatic cancer cell and CAF)

    井上 亨悦, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 川口 桂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 立川 正憲, 寺崎 哲也, 海野 倫明

    日本癌学会総会記事　73回　P-2268　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1161. Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice (vol 447, pg 346, 2014)

    Yoichi Haji, Makiko Suzuki, Kunihiko Moriya, Takanori So, Katsuto Hozumi, Masamichi Mizuma, Michiaki Unno, Naoto Ishii

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　452　(1)　206-207　2014/09

    DOI： 10.1016/j.bbrc.2014.08.099 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  1162. ヒト胃癌細胞で認められた点突然変異を有するDeoxycytidine kinaseは、完全にその機能を消失する(Gemcitabine resistance by a loss-of-function missense mutation of deoxycytidine kinase in a human gastric cancer cell)

    齋木 由利子, 平山 明由, 杉本 昌弘, 曽我 朋義, 砂村 眞琴, 元井 冬彦, 海野 倫明, 堀井 明

    日本癌学会総会記事　73回　E-3001　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1163. マウス同所移植モデルを用いた、上皮間葉転換制御遺伝子CHST11及びSERPINI1遺伝子の解析(CHST11 and SERPINI1 regulating EMT in colorectal cancer identified with an orthotopic implantation mouse model)

    松田 泰史, 三浦 康, 藤渕 航, 山根 順子, 石田 和之, 佐々木 宏之, 長尾 宗紀, 大沼 忍, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本癌学会総会記事　73回　P-3134　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1164. S-1/leucovorin隔日投与法 切除不能大腸癌化学療法の次なる治療戦略(Alternate-day administration of S-1/LV as the next therapeutic strategy for metastatic colorectal cancer patients)

    三浦 康, 白坂 哲彦, 海野 倫明, 大沼 忍, 小村 俊博, 梶原 大輝

    日本癌学会総会記事　73回　E-2017　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1165. 人工臓器と臓器移植 協調か競合か 造影超音波検査は移植膵島の生着/機能評価に有効である

    坂田 直昭, Sax Nicolas, 吉松 軍平, 土屋 朗之, 畠 達夫, 深瀬 正彦, 青木 豪, 石田 晶玄, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 小玉 哲也, 海野 倫明

    人工臓器　43　(2)　S-51　2014/09

    Publisher: (一社)日本人工臓器学会

    ISSN： 0300-0818

  1166. 当科におけるストーマ閉鎖時の吻合法についての検討 機能的端々吻合vs手縫い吻合

    長尾 宗紀, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　67　(9)　735-735　2014/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1167. 大腸癌化学療法におけるバイオマーカー 有害事象発現予測のための5-FU代謝関連酵素の遺伝子多型解析

    大沼 忍, 戸嶋 政秀, 工藤 克昌, 佐々木 宏之, 渡辺 和宏, 長尾 宗紀, 内藤 剛, 海野 倫明

    日本大腸肛門病学会雑誌　67　(9)　749-749　2014/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1168. DPYD、及びMTHFR遺伝子の1塩基多型は消化器癌患者の5-FU投与に伴う有害事象の発現を予測する(Single nucleotide polymorphisms of DPYD and MTHFR predict AEs associated with 5-FU in gastrointestinal cancer patients)

    戸嶋 政秀, 大沼 忍, 三浦 康, 田中 道廣, 武者 宏昭, 工藤 克昌, 田中 直樹, 森川 孝則, 長尾 宗紀, 内藤 剛, 片寄 友, 藤渕 航, 海野 倫明

    日本癌学会総会記事　73回　P-2391　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1169. クローン病症例における在宅中心静脈栄養療法導入基準の検討

    羽根田 祥, 大沼 忍, 武者 宏昭, 森川 孝則, 長尾 宗紀, 阿部 友哉, 田中 直樹, 工藤 克昌, 佐々木 宏之, 青木 豪, 唐澤 秀明, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　111　(臨増大会)　A879-A879　2014/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1170. p62はヒト大腸癌において細胞増殖を促進するとともに独立した予後因子である(p62/sequestosome 1 is an independent prognostic factor and promotes cell proliferation in human colorectal carcinoma)

    中山 瞬, 鈴木 貴, 藪内 伸一, 高木 清司, 小野寺 好明, 中村 保宏, 渡辺 みか, 吉田 寛, 森川 孝則, 唐澤 秀明, 内藤 剛, 海野 倫明, 笹野 公伸

    日本癌学会総会記事　73回　P-3257　2014/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1171. ANTI-DIABETIC EFFECT AND BODY WEIGHT LOSS EFFECT OF THE SLEEVE GASTRECTOMY WITH DUODENO-JEJUNAL BYPASS IN JAPANESE OBESE PATIENTS

    T. Naitoh, N. Tanaka, T. Miyachi, T. Tsuchiya, M. Nagao, T. Morikawa, H. Musha, T. Abe, S. Ohnuma, K. Kudo, T. Aoki, H. Karasawa, K. Nakagawa, H. Yoshida, F. Motoi, Y. Katayose, M. Unno

    OBESITY SURGERY　24　(8)　1345-1345　2014/08

    ISSN： 0960-8923

    eISSN： 1708-0428

  1172. 筋肉内膵島移植において細胞外基質が膵島に与える有効性の検討

    土屋朗之, 坂田直昭, 畠達夫, 深瀬正彦, 石居健太郎, 青木豪, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本移植学会総会プログラム抄録集　50th　323　2014/08

  1173. ナノバブル造影剤高周波超音波検査による移植膵島生着機能評価

    坂田直昭, SAX Nicolas, 片寄友, 江川新一, 小玉哲也, 海野倫明

    日本移植学会総会プログラム抄録集　50th　464　2014/08

  1174. 診断に苦慮した肝門部胆管癌の1例

    中野 絵里子, 菅野 敦, 正宗 淳, 三浦 晋, 廣田 衛久, 吉田 寛, 片寄 友, 海野 倫明, 下瀬川 徹

    胆道　28　(3)　548-548　2014/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1175. 家族性大腸腺腫症術後に発症し術前化学放射線療法が著効した肛門周囲膿瘍を伴った直腸癌の1例

    山村 明寛, 小川 仁, 三浦 康, 内藤 剛, 柴田 近, 海野 倫明

    外科　76　(8)　928-932　2014/08

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1176. 【現況・手技・合併症対策…肥満外科手術の最前線】 スリーブ状胃切除術+十二指腸空腸バイパス術

    内藤 剛, 田中 直樹, 海野 倫明

    手術　68　(9)　1179-1183　2014/08

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1177. MDCTに基づいたRouviere溝周囲の動脈門脈解剖 肝門部胆管癌に対する左側からの肝切除において留意すべき動脈の破格

    青木 修一, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    胆道　28　(3)　550-550　2014/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1178. NETガイドライン第1版に基づくpNET手術術式の検討

    青木 豪, 森川 孝則, 川口 桂, 坂田 直昭, 岡田 恭穂, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　69回　RS-49　2014/07

    Publisher: (一社)日本消化器外科学会

  1179. Enhanced Ultrasonography Using Nanobubble Contrast Agent for Islet Transplantation.

    N. Sakata, S. Nicolas, G. Yoshimatsu, H. Tsuchiya, T. Hata, Y. Katayose, S. Egawa, T. Kodama, M. Unno

    TRANSPLANTATION　98　678-679　2014/07

    ISSN： 0041-1337

    eISSN： 1534-6080

  1180. The Study of the Effectiveness of Extracellular Matrix On Islet Transplantation.

    H. Tsuchiya, N. Sakata, G. Yoshimatsu, T. Hata, M. Fukase, F. Motoi, Y. Katayose, S. Egawa, M. Unno

    TRANSPLANTATION　98　360-360　2014/07

    ISSN： 0041-1337

    eISSN： 1534-6080

  1181. Nerve Growth Factor Supplementation Improves Graft Survival and Function Following Islet Transplantation to Diabetic Mice.

    T. Hata, N. Sakata, G. Yoshimatsu, H. Tsuchiya, M. Fukase, F. Motoi, Y. Katayose, S. Egawa, M. Unno

    TRANSPLANTATION　98　355-355　2014/07

    ISSN： 0041-1337

    eISSN： 1534-6080

  1182. The Effect and Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells On Intramuscular Islet Transplantation.

    G. Yoshimatsu, N. Sakata, H. Tsuchiya, T. Minowa, T. Takemura, H. Morita, M. Fukase, F. Motoi, T. Naito, Y. Katayose, S. Egawa, M. Goto, M. Unno

    TRANSPLANTATION　98　332-332　2014/07

    ISSN： 0041-1337

    eISSN： 1534-6080

  1183. Metabolic Surgeryと肥満2型糖尿病治療 Bedside to Bench スリーブ胃切除とスリーブバイパス術の糖尿病改善効果と減量効果

    内藤 剛, 田中 直樹, 宮地 智洋, 土屋 堯裕, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　32回　47-47　2014/07

    Publisher: 日本肥満症治療学会

  1184. 当院の肥満外科手術の安全性と有効性

    田中 直樹, 内藤 剛, 長尾 宗紀, 宮地 智洋, 土屋 堯裕, 岡本 智子, 武田 みゆき, 澤田 正二郎, 片桐 秀樹, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　32回　88-88　2014/07

    Publisher: 日本肥満症治療学会

  1185. Alimentary limbとBiliopancreatic limbがDuodenojejunal bypassの代謝改善効果におよぼす影響 2型糖尿病モデルラットでの検討

    宮地 智洋, 長尾 宗紀, 田中 直樹, 土屋 堯裕, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　32回　102-102　2014/07

    Publisher: 日本肥満症治療学会

  1186. 食餌誘発性NASHモデルラットにおける十二指腸空腸バイパス手術のNASH改善効果の検討

    土屋 堯裕, 長尾 宗紀, 田中 直樹, 宮地 洋, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　32回　102-102　2014/07

    Publisher: 日本肥満症治療学会

  1187. 消化器外科の新たな方向性 代謝性疾患に対する外科的治療法の導入

    内藤 剛, 田中 直樹, 宮地 智洋, 土屋 堯裕, 森川 孝則, 大沼 忍, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器外科学会総会　69回　O-71　2014/07

    Publisher: (一社)日本消化器外科学会

  1188. 高齢者潰瘍性大腸炎に対する至適術式は? 腹腔鏡下大腸全摘術についての検討

    長尾 宗紀, 羽根田 祥, 神山 篤史, 工藤 克昌, 大沼 忍, 阿部 友哉, 田中 直樹, 森川 孝則, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　69回　P-11　2014/07

    Publisher: (一社)日本消化器外科学会

  1189. Clavien-Dindo分類による直腸癌術後合併症の評価

    大沼 忍, 内藤 剛, 阿部 友哉, 佐々木 宏之, 神山 篤史, 長尾 宗紀, 羽根田 祥, 森川 孝則, 片寄 友, 海野 倫明

    日本消化器外科学会総会　69回　O-98　2014/07

    Publisher: (一社)日本消化器外科学会

  1190. 高齢者肝・胆・膵疾患の治療における諸問題 75歳以上の後期高齢者に膵頭十二指腸切除術を適用する際の周術期リスクファクターは何か?

    岡田 恭穂, 元井 冬彦, 水間 正道, 中川 圭, 林 洋毅, 石田 晶玄, 川口 桂, 益田 邦洋, 藪内 伸一, 深瀬 耕二, 岡田 良, 坂田 直昭, 大塚 英郎, 森川 孝則, 吉田 寛, 片寄 友, 海野 倫明

    日本高齢消化器病学会誌　17　(1)　50-50　2014/07

    Publisher: (NPO)日本高齢消化器病学会

    ISSN： 1881-0837

  1191. 癌治療 標準化に向けた試み ガイドラインの検証 「大腸癌肺転移症例の予後分類」の国際多施設研究での検討 再発に焦点においた国際分類法の確立へむけて

    渡辺 和宏, Salah Samer, 田中 邦哉, 野尻 和典, Welter Stefan, Park Ji Won, Park Joon Suk, Zabaleta Jon, Ardissone Francesco, Riquet Marc, 海野 倫明

    日本消化器外科学会総会　69回　SY-7　2014/07

    Publisher: (一社)日本消化器外科学会

  1192. 膵癌切除例におけるmodified Glasgow Prognostic Score(mGPS)の臨床的意義

    谷口 肇, 青木 修一, 水間 正道, 阿部 友哉, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　69回　P-101　2014/07

    Publisher: (一社)日本消化器外科学会

  1193. 膵癌術前補助療法後のCA19-9値正常化が予後に与える影響

    青木 修一, 元井 冬彦, 川井 学, 庄 雅之, 上村 健一郎, 里井 壯平, 松本 逸平, 倉田 昌直, 村上 義昭, 海野 倫明, 胆膵外科研究グルー

    日本消化器外科学会総会　69回　P-124　2014/07

    Publisher: (一社)日本消化器外科学会

  1194. 腹腔鏡下胃切除術における出血例の検討と対策

    武者 宏昭, 田中 直樹, 工藤 克昌, 大沼 忍, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本消化器外科学会総会　69回　O-12　2014/07

    Publisher: (一社)日本消化器外科学会

  1195. 傍ストーマヘルニア発症の危険因子の検討

    神山 篤史, 長尾 宗紀, 羽根田 祥, 大沼 忍, 武者 宏昭, 工藤 克昌, 阿部 友哉, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　69回　RS-2　2014/07

    Publisher: (一社)日本消化器外科学会

  1196. 消化管GIST術後再発症例に対する治療成績の検討

    工藤 克昌, 武者 宏昭, 田中 直樹, 森川 孝則, 大沼 忍, 長尾 宗紀, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　69回　RS-13　2014/07

    Publisher: (一社)日本消化器外科学会

  1197. 排便と結腸運動の制御における壁在性・外来性神経の役割

    柴田 近, 染谷 崇徳, 長尾 宗紀, 内藤 剛, 武者 宏昭, 田中 直樹, 羽根田 祥, 大沼 忍, 工藤 克昌, 海野 倫明

    日本消化器外科学会総会　69回　P-31　2014/07

    Publisher: (一社)日本消化器外科学会

  1198. 当科での腹腔鏡補助下横行結腸切除における郭清手技

    阿部 友哉, 内藤 剛, 大沼 忍, 森川 孝則, 武者 宏昭, 長尾 宗紀, 佐々木 宏之, 神山 篤史, 片寄 友, 海野 倫明

    日本消化器外科学会総会　69回　O-64　2014/07

    Publisher: (一社)日本消化器外科学会

  1199. ハイリスク症例に対する腹腔鏡補助下胃切除術の周術期成績の検討

    田中 直樹, 武者 宏昭, 工藤 克昌, 森川 孝則, 青木 豪, 長尾 宗紀, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器外科学会総会　69回　RS-31　2014/07

    Publisher: (一社)日本消化器外科学会

  1200. 新しい術野展開法を用いた腹腔鏡下膵体尾部切除術

    森川 孝則, 内藤 剛, 青木 豪, 阿部 友哉, 武者 宏昭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器外科学会総会　69回　RV-27　2014/07

    Publisher: (一社)日本消化器外科学会

  1201. 被災地医療体験実習に参加した医学生の追跡調査

    田畑 雅央, 藪内 伸一, 中村 保宏, 高山 真, 水間 正道, 門馬 靖武, 松田 綾音, 千葉 宏毅, 石井 正, 海野 倫明, 金塚 完, 下瀬川 徹, 加賀谷 豊

    医学教育　45　(Suppl.)　113-113　2014/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  1202. 高齢者消化管疾患の治療における諸問題 当科における後期高齢者(75歳以上)潰瘍性大腸炎手術例の検討

    長尾 宗紀, 渡辺 和宏, 大沼 忍, 阿部 友哉, 田中 直樹, 工藤 克昌, 唐澤 秀明, 青木 豪, 武者 宏昭, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本高齢消化器病学会誌　17　(1)　38-38　2014/07

    Publisher: (NPO)日本高齢消化器病学会

    ISSN： 1881-0837

  1203. 膵管内乳頭粘液性腫瘍において見出された変異GNASの機能解析

    小松弘武, 坂田直昭, 青木豪, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明, 古川徹

    東北医学雑誌　126　(1)　61　2014/06/25

    ISSN： 0040-8700

  1204. 安全な腹腔鏡下膵切除術の普及・継承のための術野展開法

    森川孝則, 内藤剛, 青木豪, 川口桂, 益田邦洋, 岡田良, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 吉田寛, 元井冬彦, 片寄友, 江川新一, 海野倫明

    すい臓　29　(3)　494　2014/06/10

    ISSN： 0913-0071

  1205. 健康関連QOL尺度SF36v2による膵腫瘍手術の術後3ケ月評価:初期54例からの検討

    片寄友, 佐藤菜保子, 元井冬彦, 中川圭, 吉田寛, 森川孝則, 岡田恭穂, 林洋毅, 坂田直昭, 水間正道, 深瀬耕二, 青木豪, 藪内伸一, 川口桂, 江川新一, 内藤剛, 海野倫明

    すい臓　29　(3)　667　2014/06/10

    ISSN： 0913-0071

  1206. 膵癌に対する新たな治療戦略 非切除膵癌 切除不能膵癌に対する非切除療法後外科的切除の意義

    深瀬 耕二, 川口 桂, 青木 豪, 藪内 伸一, 水間 正道, 坂田 直昭, 中川 圭, 岡田 恭穂, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    膵臓　29　(3)　429-429　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1207. 臨床試験の結果に基づく膵癌に対する治療成績向上への取り組み 切除可能及び切除境界膵癌に対する術前化学療法(Neoadjuvant chemotherapy for resectable and borderline pancreatic ductal adenocarcinoma)

    川口 桂, 元井 冬彦, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　356-356　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1208. 膵腫瘍患者の手術後3ヵ月時点のQOLとFACT-Hep症状項目との関連

    佐藤 菜保子, 片寄 友, 元井 冬彦, 中川 圭, 吉田 寛, 森川 孝則, 川口 桂, 薮内 伸一, 工藤 克昌, 佐藤 昌美, 佐藤 冨美子, 海野 倫明

    日本癌治療学会誌　49　(3)　2094-2094　2014/06

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1209. 血管合併切除を伴う胆道癌手術の工夫 肝門部胆管癌に対する血管合併切除

    林 洋毅, 吉田 寛, 元井 冬彦, 中川 圭, 岡田 恭穂, 森川 孝則, 深瀬 耕二, 坂田 直昭, 水間 正道, 薮内 伸一, 青木 豪, 益田 邦洋, 川口 桂, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　369-369　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1210. 絶対に漏れない胆道再建のコツ 胆道再建に有用な縫合糸ホルダーの開発

    中川 圭, 元井 冬彦, 白崎 圭一, 吉松 軍平, 益田 邦洋, 青木 豪, 藪内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　375-375　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1211. 術後合併症を減らすための膵切除の工夫 細径膵管に対する膵腸吻合

    深瀬 耕二, 川口 桂, 益田 邦洋, 青木 豪, 藪内 伸一, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　378-378　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1212. IPMNの治療成績 残膵再発・併存癌の観点から考察したIPMNの最適術式と経過観察法

    岡田 恭穂, 元井 冬彦, 水間 正道, 川口 桂, 益田 邦洋, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 中川 圭, 林 洋毅, 吉田 寛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　392-392　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1213. 肝内胆管癌の手術治療成績と治療戦略

    益田 邦洋, 深瀬 耕二, 川口 桂, 青木 豪, 藪内 伸一, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　428-428　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1214. NET-G2に対する腫瘍径による治療方針の検討

    青木 豪, 森川 孝則, 川口 桂, 益田 邦洋, 藪内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　743-743　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1215. Combined Addition of Interleukin-6 and Dexamethasone Prevented Reg Protein-induced beta-Cell Apoptosis through Activation of HGF Gene Transcription

    Shin Takasawa, Kei Nakagawa, Koji Nata, Akiyo Yamauchi, Asako Itaya-Hironaka, Hiroyo Ota, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Takanori Fujimura, Hiroki Tsujinaka, Michiaki Unno, Hiroshi Okamoto

    DIABETES　63　A536-A536　2014/06

    ISSN： 0012-1797

    eISSN： 1939-327X

  1216. The Effect and Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells On Intramuscular Islet Transplantation

    G. Yoshimatsu, N. Sakata, H. Tsuchiya, T. Minowa, T. Takemura, H. Morita, M. Fukase, F. Motoi, T. Naito, Y. Katayose, S. Egawa, M. Goto, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　14　332-332　2014/06

    ISSN： 1600-6135

    eISSN： 1600-6143

  1217. The Study of the Effectiveness of Extracellular Matrix On Islet Transplantation.

    H. Tsuchiya, N. Sakata, G. Yoshimatsu, T. Hata, M. Fukase, F. Motoi, Y. Katayose, S. Egawa, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　14　360-360　2014/06

    ISSN： 1600-6135

    eISSN： 1600-6143

  1218. Nerve Growth Factor Supplementation Improves Graft Survival and Function Following Islet Transplantation to Diabetic Mice

    T. Hata, N. Sakata, G. Yoshimatsu, H. Tsuchiya, M. Fukase, F. Motoi, Y. Katayose, S. Egawa, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　14　355-355　2014/06

    ISSN： 1600-6135

    eISSN： 1600-6143

  1219. Enhanced Ultrasonography Using Nanobubble Contrast Agent for Islet Transplantation.

    N. Sakata, S. Nicolas, G. Yoshimatsu, H. Tsuchiya, T. Hata, Y. Katayose, S. Egawa, T. Kodama, M. Unno

    AMERICAN JOURNAL OF TRANSPLANTATION　14　678-679　2014/06

    ISSN： 1600-6135

    eISSN： 1600-6143

  1220. 【癌の補助療法アップデート】 胆道癌 補助化学療法についての今後の展望

    深瀬 耕二, 林, 洋毅, 片寄, 友, 海野 倫明

    臨床外科　69　(6)　712-717　2014/06

    DOI： 10.11477/mf.1407105082 　

  1221. 高度技能専門医を取得して

    吉田 寛, 片寄 友, 元井 冬彦, 岡田 恭穂, 森川 孝則, 中川 圭, 林 洋毅, 坂田 直昭, 大塚 英郎, 水間 正道, 深瀬 耕二, 藪内 伸一, 石田 晶玄, 青木 豪, 岡田 良, 益田 邦洋, 川口 桂, 内藤 剛, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　337-337　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1222. 【膵がん退治の始まり】 進展度診断と治療アルゴリズム

    水間 正道, 元井 冬彦, 青木 修一, 片寄 友, 江川 新一, 海野 倫明

    肝・胆・膵　68　(6)　865-870　2014/06

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1223. 術後CA19-9値の遷延上昇は、肝転移再発・予後不良のリスク因子である

    元井 冬彦, 村上 義昭, 川井 学, 松本 逸平, 上村 健一郎, 里井 壯平, 庄 雅之, 本田 五郎, 山上 裕機, 後藤 直大, 柳本 泰明, 木下 正一, 倉田 昌直, 青木 修一, 水間 正道, 海野 倫明, Multicenter Study, Group of Pancreatobiliary Surgery

    膵臓　29　(3)　379-379　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1224. 膵癌に対する新たな治療戦略 切除可能膵癌 術前治療後のCA19-9値正常化は、切除可能膵癌の重要な予後因子である

    青木 修一, 元井 冬彦, 水間 正道, 村上 義昭, 庄 雅之, 里井 壮平, 本田 五郎, 上村 健一郎, 川井 学, 松本 逸平, 海野 倫明, 胆膵外科研究グルー

    膵臓　29　(3)　391-391　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1225. 胃癌手術症例に対するcontrolling nutritional status法による術前栄養評価と術後合併症の評価

    工藤 克昌, 柴田 近, 武者 宏昭, 田中 直樹, 大沼 忍, 羽根田 祥, 神山 篤史, 中川 圭, 内藤 剛, 海野 倫明

    日本消化器外科学会雑誌　47　(6)　305-312　2014/06

    Publisher: (一社)日本消化器外科学会

    DOI： 10.5833/jjgs.2013.0171 　

    ISSN： 0386-9768

  1226. S-1連日投与による5-FU消化管障害マウスモデルの免疫学的評価 S-1隔日投与法の有用性

    梶原 大輝, 三浦 康, 白坂 哲彦, 大沼 忍, 小村 俊博, 工藤 克昌, 羽根田 祥, 長尾 宗紀, 阿部 友哉, 田中 直樹, 武者 宏昭, 元井 冬彦, 片寄 友, 内藤 剛, 海野 倫明

    日本癌治療学会誌　49　(3)　2273-2273　2014/06

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1227. 膵癌に対する新たな治療戦略 切除可能膵癌 切除膵癌の予後不良因子の検索に基づいた術前GS療法の有用性

    元井 冬彦, 川口 桂, 益田 邦洋, 唐澤 秀明, 青木 豪, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    膵臓　29　(3)　409-409　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1228. 膵癌診療におけるDUPAN-2の有用性 予後との関連から

    水間 正道, 元井 冬彦, 青木 修一, 川口 桂, 益田 邦洋, 唐澤 秀明, 岡田 良, 薮内 伸一, 深瀬 耕二, 坂田 直昭, 中川 圭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 下瀬川 徹, 海野 倫明

    膵臓　29　(3)　640-640　2014/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1229. CA19-9正常膵癌に対する予後予測におけるDUPAN-2の有用性

    水間 正道, 元井 冬彦, 青木 修一, 阿部 友哉, 川口 桂, 唐澤 秀明, 益田 邦洋, 青木 豪, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　26回　703-703　2014/06

    Publisher: (一社)日本肝胆膵外科学会

  1230. 進行大腸癌に対する骨盤内臓全摘術の治療成績

    大沼 忍, 内藤 剛, 戸嶋 政秀, 唐澤 秀明, 青木 豪, 工藤 克昌, 田中 直樹, 羽根田 祥, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 森川 孝則, 元井 冬彦, 片寄 友, 海野 倫明

    日本癌治療学会誌　49　(3)　2043-2043　2014/06

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1231. Surgical treatment for distal bile duct cancer

    海野倫明, 青木豪, 吉田寛, 元井冬彦, 片寄友

    胆道　28　(2)　249-253　2014/05/31

    DOI： 10.11210/tando.28.249 　

    ISSN： 0914-0077

  1232. The Impact of Pancreatic Fistula Grade C on Survival After Pancreatic Resection; Analysis of 1,015 Patients With Pancreatic Cancer in Multicenter Study

    Manabu Kawai, Yoshiaki Murakami, Masaji Tani, Seiko Hirono, Ken-ichi Okada, Fuyuhiko Motoi, Michiaki Unno, Masayuki Sho, Yoshiyuki Nakajima, Kenichiro Uemura, Sohei Satoi, A-Hon Kwon, Ippei Matsumoto, Tadahiro Goto, Goro Honda, Masanao Kurata, Hiroki Yamaue

    GASTROENTEROLOGY　146　(5)　S1047-S1048　2014/05

    ISSN： 0016-5085

    eISSN： 1528-0012

  1233. Is Partial Resection of Portal or Superior Mesenteric Vein Justified for Patients With Pancreatic Head Carcinoma?

    Yoshiaki Murakami, Kenichiro Uemura, Sohei Satoi, Masayuki Sho, Fuyuhiko Motoi, Goro Honda, Manabu Kawai, Ippei Matsumoto, Seiko Hirono, Masanao Kurata, Hiroaki Yanagimoto, Takahiro Akahori, Makoto Shinzeki, Michiaki Unno

    GASTROENTEROLOGY　146　(5)　S1047-S1047　2014/05

    ISSN： 0016-5085

    eISSN： 1528-0012

  1234. Impact of Preoperative Biliary Drainage on Short- and Long-Term Outcome After Pancreaticoduodenectomy for Cancer of the Head of Pancreas

    Kenichiro Uemura, Yoshiaki Murakami, Manabu Kawai, Ken-ichi Okada, Ippei Matsumoto, Sadaki Asari, Sohei Satoi, Hiroaki Yanagimoto, Masayuki Sho, Takahiro Akahori, Goro Honda, Masanao Kurata, Fuyuhiko Motoi, Michiaki Unno

    GASTROENTEROLOGY　146　(5)　S1045-S1046　2014/05

    ISSN： 0016-5085

    eISSN： 1528-0012

  1235. Reappraisal of Peritoneal Cytology in 984 Patients With Pancreatic Cancer Who Underwent Curative Resection

    Sohei Satoi, Fuyuhiko Motoi, Kenichiro Uemura, Manabu Kawai, Masanao Kurata, Masayuki Sho, Ippei Matsumoto, Hiroaki Yanagimoto, Michiaki Unno, Hiroki Yamaue, Goro Honda, Yoshiyuki Nakajima, Makoto Shinzeki, A-Hon Kwon, Yoshiaki Murakami

    GASTROENTEROLOGY　146　(5)　S1030-S1030　2014/05

    ISSN： 0016-5085

    eISSN： 1528-0012

  1236. 【肥満・糖尿病に対する外科的治療】 糖尿病に対する外科手術(メタボリックサージェリー)

    内藤 剛, 田中 直樹, 海野 倫明

    月刊糖尿病　6　(4)　32-37　2014/05

    Publisher: (株)医学出版

  1237. 【最新肥満症学-基礎・臨床研究の最前線-】 肥満症の予防・治療 肥満外科療法 肥満外科療法の術式と適応

    内藤 剛, 田中 直樹, 柴田 近, 海野 倫明

    日本臨床　72　(増刊4 最新肥満症学)　521-524　2014/05

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  1238. 5度の肝転移再発に繰り返し肝切除を行うことで長期生存を得た小腸GIST同時性巨大肝転移の1例

    青木 修一, 水間 正道, 林 洋毅, 内藤 剛, 片寄 友, 海野 倫明

    臨床外科　69　(5)　597-603　2014/05

    Publisher: (株)医学書院

    ISSN： 0386-9857

  1239. 肝臓の手術 肝内結石症 肝左葉切除術・外側区域切除術

    青木豪, 海野倫明

    消化器外科　37　(5)　799-802　2014/04/20

    ISSN： 0387-2645

  1240. Surgical resection after adjuvant therapy for initially unresectable pancreatic cancer

    69　(4)　447-452　2014/04

    Publisher: 医学書院

    ISSN： 0386-9857

  1241. 気遣いの内視鏡外科手術 肝・胆・膵 先天性胆管拡張症に対する腹腔鏡下手術

    内藤 剛, 森川 孝則, 海野 倫明

    Gastroenterological Endoscopy　56　(Suppl.1)　947-947　2014/04

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

  1242. PS-168-4 膵実質・断端の所見から見たIPMN残膵再発を防ぐための最適な術式・経過観察法(PS-168 膵 IPMN-2,ポスターセッション,第114回日本外科学会定期学術集会)

    岡田 恭穂, 水間 正道, 元井 冬彦, 畠 達夫, 川口 桂, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 片寄 友, 海野 倫明

    日本外科学会雑誌　115　(2)　910-910　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1243. 大腸癌同時性肝転移症例の治療戦略

    中川圭, 片寄友, 大沼忍, 及川昌也, 山内淳一郎, 島村弘宗, 山本久二治, 高橋賢一, 児玉英謙, 高橋道長, 遠藤公人, 三浦康, 柴田近, 江川新一, 元井冬彦, 海野倫明

    日本外科学会雑誌　115　121　2014/03/05

    ISSN： 0301-4894

  1244. マウスモデルにおける骨髄由来間葉系幹細胞が膵島に及ぼす影響とそのメカニズムについて

    吉松軍平, 坂田直昭, 箕輪貴司, 竹村太郎, 森田浩美, 土屋朗之, 畠達夫, 深瀬正彦, 青木豪, 中川圭, 林洋毅, 岡田恭穂, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　115　923　2014/03/05

    ISSN： 0301-4894

  1245. 膵島移植における神経成長因子(Nerve Growth Factor)の役割と機能解析

    畠達夫, 坂田直昭, 吉松軍平, 土屋朗之, 深瀬正彦, 青木豪, 川口桂, 薮内伸一, 深瀬耕二, 水間正道, 中川圭, 林洋毅, 岡田恭穂, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本外科学会雑誌　115　406　2014/03/05

    ISSN： 0301-4894

  1246. SY-2-1 大腸癌同時性肝転移症例の治療戦略(SY-2 シンポジウム(2)大腸癌肝転移の治療戦略-切除の適応とタイミング-,第114回日本外科学会定期学術集会)

    中川 圭, 片寄 友, 大沼 忍, 及川 昌也, 山内 淳一郎, 島村 弘宗, 山本 久二治, 高橋 賢一, 児玉 英謙, 高橋 道長, 遠藤 公人, 三浦 康, 柴田 近, 江川 新一, 元井 冬彦, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1247. OP-051-3 膵島移植における神経成長因子(Nerve Growth Factor)の役割と機能解析(OP-051 膵 基礎治療標的・移植,一般演題,第114回日本外科学会定期学術集会)

    畠 達夫, 坂田 直昭, 吉松 軍平, 土屋 朗之, 深瀬 正彦, 青木 豪, 川口 桂, 薮内 伸一, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1248. PS-083-8 マウス門脈枝結紮後の代償的肝肥大におけるNrf2の役割(PS-083 肝 基礎-3,ポスターセッション,第114回日本外科学会定期学術集会)

    白崎 圭一, 藪内 伸一, 田口 恵子, 川口 桂, 唐澤 秀明, 青木 豪, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 本橋 ほづみ, 山本 雅之, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1249. PS-164-5 術前CA19-9値正常の膵癌におけるCA19-9値と予後との関係(PS-164 膵 予後,ポスターセッション,第114回日本外科学会定期学術集会)

    青木 修一, 水間 正道, 元井 冬彦, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 坂田 直昭, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1250. PS-174-5 マウスモデルにおける骨髄由来間葉系幹細胞が膵島に及ぼす影響とそのメカニズムについて(PS-174 基礎 臓器移植,ポスターセッション,第114回日本外科学会定期学術集会)

    吉松 軍平, 坂田 直昭, 箕輪 貴司, 竹村 太郎, 森田 浩美, 土屋 朗之, 畠 達夫, 深瀬 正彦, 青木 豪, 中川 圭, 林 洋毅, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1251. SY-4-4 Borderline Resectable(BR)膵癌に対する治療戦略 : NCCN定義の再考と術前GS療の意義(SY-4 シンポジウム(4)Borderline resectable膵癌-術前診断と治療方針の将来展望-,第114回日本外科学会定期学術集会)

    元井 冬彦, 川口 桂, 唐澤 秀明, 青木 豪, 工藤 克昌, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1252. OP-024-5 胆管癌に対する術前化学放射線療法の安全性と病理組織的効果の検討(OP-024 胆 悪性 胆道癌-1,一般演題,第114回日本外科学会定期学術集会)

    片寄 友, 中川 圭, 吉田 寛, 森川 孝則, 林 洋毅, 岡田 恭穗, 水間 正道, 坂田 直昭, 深瀬 耕二, 藪内 伸一, 川口 桂, 青木 豪, 工藤 克昌, 唐澤 秀明, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1253. WS-9-7 WHO分類によるpNET手術術式の検討(WS-9 ワークショップ(9)本邦におけるNET治療の実態-診療ガイドラインへの展開-,第114回日本外科学会定期学術集会)

    青木 豪, 森川 孝則, 川口 桂, 唐沢 秀明, 神山 篤史, 工藤 克昌, 藪内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1254. PS-011-5 当教室における胆管内乳頭状腫瘍(IPNB)の治療成績(PS-011 胆 悪性-3,ポスターセッション,第114回日本外科学会定期学術集会)

    水間 正道, 森川 孝則, 川口 桂, 唐澤 秀明, 青木 豪, 工藤 克昌, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1255. OP-012-1 潰瘍性大腸炎関連大腸癌39例の検討(OP-012 炎症性腸疾患-2,一般演題,第114回日本外科学会定期学術集会)

    神山 篤史, 高橋 賢一, 生澤 史江, 舟山 裕士, 柴田 近, 内藤 剛, 森川 孝則, 大沼 忍, 羽根田 祥, 長尾 宗紀, 工藤 克昌, 武者 宏昭, 田中 直樹, 佐々木 宏之, 阿部 友哉, 青木 豪, 元井 冬彦, 吉田 寛, 江川 新一, 片寄 友, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1256. DB-3-1 噴門側胃切除(DB-3 ディベート(3)「胃上部早期胃がんに対する術式選択:噴門側胃切除vs胃全摘術」,第114回日本外科学会定期学術集会)

    武者 宏昭, 田中 直樹, 工藤 昌克, 安本 明浩, 大沼 忍, 羽根田 祥, 神山 篤, 阿部 友哉, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 徳村 弘実, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1257. OP-008-7 腹腔鏡下膵切除術は膵神経内分泌腫瘍に対する第一選択術式である(OP-008 膵 内分泌腫瘍,一般演題,第114回日本外科学会定期学術集会)

    森川 孝則, 内藤 剛, 青木 豪, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 長尾 宗紀, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1258. OP-013-1 当科における高齢者(50歳以上)潰瘍性大腸炎手術例の検討(OP-013 炎症性腸疾患-3,一般演題,第114回日本外科学会定期学術集会)

    長尾 宗紀, 羽根田 祥, 田中 直樹, 佐々木 宏之, 大沼 忍, 神山 篤史, 工藤 克昌, 阿部 友哉, 武者 宏昭, 森川 孝則, 坂田 直昭, 林 洋毅, 岡田 恭穂, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1259. OP-090-2 腹腔鏡下右側結腸切除術における至適郭清範囲と郭清手技(OP-090 大腸 リンパ節郭清・その他-1,一般演題,第114回日本外科学会定期学術集会)

    内藤 剛, 大沼 忍, 阿部 友哉, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 森川 孝則, 武者 宏昭, 田中 直樹, 工藤 克昌, 神山 篤史, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 坂田 直昭, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1260. OP-141-5 長期生存症例の特徴から見た直腸癌局所再発に対する外科治療(OP-141 直腸 局所再発,一般演題,第114回日本外科学会定期学術集会)

    大沼 忍, 内藤 剛, 阿部 友哉, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 神山 篤史, 森川 孝則, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1261. PS-016-8 膵神経内分泌腫瘍におけるグルカゴン受容体の発現と臨床病理学的因子の関連(PS-016 膵 腫瘍 NET-2,ポスターセッション,第114回日本外科学会定期学術集会)

    柴田 近, 笠島 敦子, 内藤 剛, 森川 孝則, 武者 宏明, 阿部 友哉, 長尾 宗紀, 田中 直樹, 羽根田 祥, 大沼 忍, 工藤 克昌, 佐々木 宏之, 青木 豪, 神山 篤史, 岡田 恭穂, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 笹野 公伸, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1262. PS-036-3 クローン病におけるHPN導入基準の検討(PS-036 炎症性腸疾患 その他,ポスターセッション,第114回日本外科学会定期学術集会)

    羽根田 祥, 長尾 宗紀, 工藤 克昌, 神山 篤史, 森川 孝則, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1263. PS-061-8 胃癌手術症例におけるCONUT法による術前栄養評価と術後長期成績の検討(PS-061 胃 その他-1,ポスターセッション,第114回日本外科学会定期学術集会)

    工藤 克昌, 武者 宏昭, 田中 直樹, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 森川 孝則, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1264. PS-140-4 胃切除術周術期の体重減少と体組成変化(PS-140 胃 周術期管理,ポスターセッション,第114回日本外科学会定期学術集会)

    田中 直樹, 武者 宏昭, 工藤 克昌, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 森川 孝則, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(2)　2014/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1265. 膵実質・断端の所見から見たIPMN残膵再発を防ぐための最適な術式・経過観察法

    岡田 恭穂, 水間 正道, 元井 冬彦, 畠 達夫, 川口 桂, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 片寄 友, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　910-910　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1266. 浸潤部の組織型からみたIPMN由来浸潤癌の予後と補助化学療法の適応

    畠 達夫, 岡田 恭穂, 坂田 直昭, 青木 豪, 川口 桂, 益田 邦洋, 薮内 伸一, 深瀬 耕二, 水間 正道, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A300-A300　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1267. 【肝胆膵腫瘍のバイオインフォマティクス】 診断・治療におけるバイオマーカーと治療標的分子 難治性腫瘍の早期診断マーカー 胆・膵腫瘍の分子標的治療とバイオマーカー

    水間 正道, 高舘 達之, 元井 冬彦, 片寄 友, 海野 倫明

    肝・胆・膵　68　(3)　421-428　2014/03

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1268. 本邦におけるNET治療の実態 診療ガイドラインへの展開 WHO分類によるpNET手術術式の検討

    青木 豪, 森川 孝則, 川口 桂, 唐沢 秀明, 神山 篤史, 工藤 克昌, 藪内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　225-225　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1269. 【ディベート 炎症性腸疾患の外科治療】 切除吻合法(手縫い吻合vs器械吻合) 東北大学法

    渡辺 和宏, 長尾 宗紀, 羽根田 祥, 舟山 裕士, 高橋 賢一, 内藤 剛, 海野 倫明, 福島 浩平

    外科　76　(3)　261-266　2014/03

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1270. 【胆道癌として外科切除された鑑別困難病変の検証-画像と病理所見の対比-】 胆嚢癌と鑑別困難な黄色肉芽腫性胆嚢炎切除例

    益田 邦洋, 吉田 寛, 内藤 剛, 海野 倫明

    胆と膵　35　(3)　283-289　2014/03

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1271. 術前CA19-9値正常の膵癌におけるCA19-9値と予後との関係

    青木 修一, 水間 正道, 元井 冬彦, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 坂田 直昭, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　903-903　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1272. 膵神経内分泌腫瘍におけるグルカゴン受容体の発現と臨床病理学的因子の関連

    柴田 近, 笠島 敦子, 内藤 剛, 森川 孝則, 武者 宏明, 阿部 友哉, 長尾 宗紀, 田中 直樹, 羽根田 祥, 大沼 忍, 工藤 克昌, 佐々木 宏之, 青木 豪, 神山 篤史, 岡田 恭穂, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 笹野 公伸, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　607-607　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1273. 5-FU投与患者におけるジヒドロピリミジンデヒドロゲナーゼ遺伝子多型とその表現型の解析

    戸嶋 政秀, 大沼 忍, 三浦 康, 田中 道廣, 武者 宏昭, 羽根田 祥, 工藤 克昌, 神山 篤史, 梶原 大輝, 小村 俊博, 小林 実, 元井 冬彦, 内藤 剛, 柴田 近, 片寄 友, 海野 倫明

    日本大腸肛門病学会雑誌　67　(3)　240-240　2014/03

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1274. 腹腔鏡下膵切除術は膵神経内分泌腫瘍に対する第一選択術式である

    森川 孝則, 内藤 剛, 青木 豪, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 長尾 宗紀, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　326-326　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1275. 潰瘍性大腸炎関連大腸癌39例の検討

    神山 篤史, 高橋 賢一, 生澤 史江, 舟山 裕士, 柴田 近, 内藤 剛, 森川 孝則, 大沼 忍, 羽根田 祥, 長尾 宗紀, 工藤 克昌, 武者 宏昭, 田中 直樹, 佐々木 宏之, 阿部 友哉, 青木 豪, 元井 冬彦, 吉田 寛, 江川 新一, 片寄 友, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　332-332　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1276. 当科における高齢者(50歳以上)潰瘍性大腸炎手術例の検討

    長尾 宗紀, 羽根田 祥, 田中 直樹, 佐々木 宏之, 大沼 忍, 神山 篤史, 工藤 克昌, 阿部 友哉, 武者 宏昭, 森川 孝則, 坂田 直昭, 林 洋毅, 岡田 恭穂, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　334-334　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1277. 高齢者(50歳以上)潰瘍性大腸炎手術例における術式選択

    長尾 宗紀, 羽根田 祥, 田中 直樹, 佐々木 宏之, 大沼 忍, 神山 篤史, 工藤 克昌, 阿部 友哉, 武者 宏昭, 森川 孝則, 坂田 直昭, 林 洋毅, 岡田 恭穂, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A259-A259　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1278. 結腸運動と排便の制御における壁在性神経の連続性と外来神経の役割

    柴田 近, 染谷 崇徳, 長尾 宗紀, 宮地 智洋, 林 啓一, 内藤 剛, 武者 宏昭, 森川 孝則, 大沼 忍, 工藤 克昌, 田中 直樹, 羽根田 祥, 佐々木 宏之, 神山 篤史, 青木 豪, 吉田 寛, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A322-A322　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1279. 進行胃癌における腹腔鏡下胃切除術の治療成績

    武者 宏昭, 内藤 剛, 神山 篤, 工藤 克昌, 大沼 忍, 羽根田 祥, 田中 直樹, 長尾 宗紀, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本胃癌学会総会記事　86回　237-237　2014/03

    Publisher: (一社)日本胃癌学会

  1280. 腹腔鏡補助下胃切除術の周術期成績と手術リスク

    田中 直樹, 鹿郷 昌之, 柴田 近, 武者 宏昭, 工藤 克昌, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 長尾 宗紀, 佐々木 宏之, 森川 孝則, 元井 冬彦, 内藤 剛, 海野 倫明

    日本胃癌学会総会記事　86回　325-325　2014/03

    Publisher: (一社)日本胃癌学会

  1281. 胃癌手術術後1年後の体重減少の検討

    工藤 克昌, 柴田 近, 武者 宏昭, 田中 直樹, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 長尾 宗紀, 佐々木 宏之, 森川 孝則, 青木 豪, 内藤 剛, 元井 冬彦, 海野 倫明

    日本胃癌学会総会記事　86回　342-342　2014/03

    Publisher: (一社)日本胃癌学会

  1282. Borderline resectable膵癌 術前診断と治療方針の将来展望 Borderline Resectable(BR)膵癌に対する治療戦略 NCCN定義の再考と術前GS療の意義

    元井 冬彦, 川口 桂, 唐澤 秀明, 青木 豪, 工藤 克昌, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　128-128　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1283. 胃上部早期胃がんに対する術式選択:噴門側胃切除vs胃全摘術 噴門側胃切除

    武者 宏昭, 田中 直樹, 工藤 昌克, 安本 明浩, 大沼 忍, 羽根田 祥, 神山 篤, 阿部 友哉, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 徳村 弘実, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　258-258　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1284. 胆管癌に対する術前化学放射線療法の安全性と病理組織的効果の検討

    片寄 友, 中川 圭, 吉田 寛, 森川 孝則, 林 洋毅, 岡田 恭穗, 水間 正道, 坂田 直昭, 深瀬 耕二, 藪内 伸一, 川口 桂, 青木 豪, 工藤 克昌, 唐澤 秀明, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　356-356　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1285. 腹腔鏡下右側結腸切除術における至適郭清範囲と郭清手技

    内藤 剛, 大沼 忍, 阿部 友哉, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 森川 孝則, 武者 宏昭, 田中 直樹, 工藤 克昌, 神山 篤史, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 坂田 直昭, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　474-474　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1286. 長期生存症例の特徴から見た直腸癌局所再発に対する外科治療

    大沼 忍, 内藤 剛, 阿部 友哉, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 神山 篤史, 森川 孝則, 武者 宏昭, 田中 直樹, 工藤 克昌, 青木 豪, 唐澤 秀明, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　564-564　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1287. 当教室における胆管内乳頭状腫瘍(IPNB)の治療成績

    水間 正道, 森川 孝則, 川口 桂, 唐澤 秀明, 青木 豪, 工藤 克昌, 藪内 伸一, 深瀬 耕二, 坂田 直昭, 岡田 恭穂, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　597-597　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1288. クローン病におけるHPN導入基準の検討

    羽根田 祥, 長尾 宗紀, 工藤 克昌, 神山 篤史, 森川 孝則, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　646-646　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1289. 胃癌手術症例におけるCONUT法による術前栄養評価と術後長期成績の検討

    工藤 克昌, 武者 宏昭, 田中 直樹, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 森川 孝則, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　697-697　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1290. マウス門脈枝結紮後の代償的肝肥大におけるNrf2の役割

    白崎 圭一, 藪内 伸一, 田口 恵子, 川口 桂, 唐澤 秀明, 青木 豪, 深瀬 耕二, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 岡田 恭穂, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 橋本 ほづみ, 山本 雅之, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　741-741　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1291. 胃切除術周術期の体重減少と体組成変化

    田中 直樹, 武者 宏昭, 工藤 克昌, 大沼 忍, 羽根田 祥, 神山 篤史, 阿部 友哉, 森川 孝則, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 中川 圭, 岡田 恭穂, 片寄 友, 内藤 剛, 柴田 近, 海野 倫明

    日本外科学会雑誌　115　(臨増2)　854-854　2014/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1292. クローン病における腸管不全発症症例の検討

    羽根田 祥, 長尾 宗紀, 工藤 克昌, 神山 篤史, 森川 孝則, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 佐々木 宏之, 青木 豪, 唐澤 秀明, 元井 冬彦, 吉田 寛, 林 洋毅, 岡田 恭穂, 中川 圭, 片寄 友, 内藤 剛, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A244-A244　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1293. クローン病癌化15例の検討

    神山 篤史, 羽根田 祥, 長尾 宗紀, 大沼 忍, 工藤 克昌, 田中 直樹, 武者 宏昭, 阿部 友哉, 高橋 賢一, 生澤 史江, 舟山 裕士, 内藤 剛, 森川 孝則, 片寄 友, 江川 新一, 元井 冬彦, 佐々木 宏之, 青木 豪, 唐澤 秀明, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A259-A259　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1294. 胃癌手術例における術後1年後の体重変化の検討

    工藤 克昌, 武者 宏昭, 田中 直樹, 大沼 忍, 羽根田 祥, 神山 篤史, 森川 孝則, 阿部 友哉, 長尾 宗紀, 佐々木 宏之, 青木 豪, 唐澤 秀明, 吉田 寛, 中川 圭, 柴田 近, 元井 冬彦, 内藤 剛, 江川 新一, 片寄 友, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A285-A285　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1295. 当科における多発性内分泌腫瘍症(MEN)1型に伴う膵神経内分泌腫瘍(pNET)5例の検討

    片桐 宗利, 森川 孝則, 薮内 伸一, 唐澤 秀明, 坂田 直昭, 水間 正道, 深瀬 耕二, 青木 豪, 川口 桂, 武者 宏昭, 中川 圭, 岡田 恭穂, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本消化器病学会雑誌　111　(臨増総会)　A436-A436　2014/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1296. 膵頭十二指腸切除術後に生じた仮性動脈瘤からの出血に対するIVR アンスロンカテーテルを用いたTAEの経験

    川口 桂, 元井 冬彦, 薮内 伸一, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　34　(2)　444-444　2014/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1297. マウスモデルにおける筋肉内膵島移植に対する骨髄由来間葉系幹細胞共移植の効果

    吉松軍平, 坂田直昭, 土屋朗之, 畠達夫, 深瀬正彦, 青木豪, 森田浩美, 竹村太郎, 箕輪貴司, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　41st　80　2014/02

  1298. 神経成長因子(Nerve Growth Factor)が膵島に与える影響と膵島移植の効率化についての検討

    畠達夫, 坂田直昭, 吉松軍平, 土屋朗之, 深瀬正彦, 青木豪, 岡田恭穂, 中川圭, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　41st　75　2014/02

  1299. 細胞外基質が膵島に与える有効性の検討

    土屋朗之, 坂田直昭, 吉松軍平, 畠達夫, 深瀬正彦, 青木豪, 岡田恭穂, 中川圭, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　41st　76　2014/02

  1300. 自家膵島移植の経験とその検討

    坂田直昭, 後藤昌史, 吉松軍平, 畠達夫, 林洋毅, 中川圭, 山谷英之, 澤田正二郎, 廣田衛久, 元井冬彦, 江川新一, 片桐秀樹, 下瀬川徹, 里見進, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　41st　60　2014/02

  1301. 当科における急性胆嚢炎手術症例の検討

    阿部 友哉, 内藤 剛, 森川 孝則, 大沼 忍, 武者 宏昭, 田中 直樹, 片寄 友, 元井 冬彦, 吉田 寛, 海野 倫明

    日本腹部救急医学会雑誌　34　(2)　439-439　2014/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1302. 尿管による絞扼性イレウスの1例

    小林 実, 大沼 忍, 神山 篤史, 青木 豪, 工藤 克昌, 羽根田 祥, 長尾 宗紀, 田中 直樹, 阿部 友哉, 森川 孝則, 武者 宏昭, 内藤 剛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　34　(2)　481-481　2014/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1303. 腸管気腫を伴ったイレウスの1例

    小原 恵, 大沼 忍, 神山 篤史, 青木 豪, 工藤 克昌, 羽根田 祥, 田中 直樹, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 森川 孝則, 内藤 剛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　34　(2)　540-540　2014/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1304. 急性消化管GVHDの経過中、腸管気腫症に伴った腸管壁内出血に対して結腸切除術を施行した1例

    佐藤 純, 藪内 伸一, 唐澤 秀明, 森川 孝則, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本腹部救急医学会雑誌　34　(2)　545-545　2014/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1305. 消化器外科 1.膵神経内分泌腫瘍(pNET)の診断と外科治療

    青木豪, 坂田直昭, 元井冬彦, 海野倫明

    Annual Review 消化器　2014　271-277　2014/01/30

  1306. 大腸癌肝転移に対するmFOLFOX6+BmabとmFOLFOX6+Cmabの第II相臨床試験(ATOM trial)

    室圭, 江見泰徳, 山中竹春, 片寄友, 植竹宏之, 井村穣二, 坂元亨宇, 相島慎一, 石田和之, 杉原健一, 掛地吉弘, 海野倫明, 兵頭一之介, 富田尚裕, 前原喜彦

    日本癌治療学会学術集会(CD-ROM)　52nd　2014

  1307. Prospective observational study on chemotherapy-induced nausea and vomiting (CINV) for hepatobiliary and pancreatic cancer patients who were to receive chemotherapy including cisplatin by the CINV study group of Japan

    Junji Furuse, Hideo Baba, Shinichi Ohkawa, Kazuya Sugimori, Kazuhide Yamamoto, Hironobu Minami, Yuko Kitagawa, Hidekazu Kuramochi, A-Hon Kwon, Michiaki Unno, Go Wakabayashi, Keisuke Aiba, Kazuo Tamura

    JOURNAL OF CLINICAL ONCOLOGY　32　(3)　2014/01

    ISSN： 0732-183X

    eISSN： 1527-7755

  1308. Strategy for clinical setting in intramuscular and subcutaneous islet transplantation

    Naoaki Sakata, Takeshi Aoki, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Tatsuo Hata, Yu Katayose, Shinichi Egawa, Michiaki Unno

    DIABETES-METABOLISM RESEARCH AND REVIEWS　30　(1)　1-10　2014/01

    DOI： 10.1002/dmrr.2463 　

    ISSN： 1520-7560

  1309. REVIEW OF SURGICAL TREATMENT OF PERIHILAR CHOLANGIOCARCINOMA : PROPER PATIENT SELECTION FOR COMBINED VASCULAR RESECTION AND RECONSTRUCTION

    Unno Michiaki

    Journal of Japan Surgical Society　115　(4)　181-184　2014

    Publisher: Japan Surgical Society (JSS)

    ISSN： 0301-4894

  1310. The impact of histologic tumor response on survival of patients treated with neoadjuvant mFOLFOX6 plus bevacizumab for the synchronous liver metastases from colorectal cancer.

    Yu Katayose, Kazuyuki Ishida, Kei Nakagawa, Junichiro Yamauchi, Masaya Oikawa, Naoki Sakurai, Hiroaki Musha, Hiromune Shimamura, Koh Miura, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno

    JOURNAL OF CLINICAL ONCOLOGY　32　(3)　2014/01

    ISSN： 0732-183X

    eISSN： 1527-7755

  1311. Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma: A prospective, multi-institutional, phase II trial

    Masamichi Mizuma, Fuyuhiko Motoi, Kazuyuki Ishida, Fumiyoshi Fujishima, Shigeru Ottomo, Masaya Oikawa, Takaho Okada, Hiromune Shimamura, Shinichi Takemura, Fuminori Ono, Masanori Akada, Kei Nakagawa, Yu Katayose, Shinichi Egawa, Michiaki Unno

    JOURNAL OF CLINICAL ONCOLOGY　32　(3)　2014/01

    ISSN： 0732-183X

    eISSN： 1527-7755

  1312. 膵癌切除後血清CA19‐9値正常化後生存は有用な代理指標である

    元井冬彦, 岡田良, 水間正道, 森川孝則, 林洋毅, 中川圭, 吉田寛, 片寄友, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　52nd　ROMBUNNO.O32-6　2014

  1313. 直腸神経内分泌腫瘍に対する治療方針の検討

    神山篤史, 大沼忍, 阿部友哉, 長尾宗紀, 武者宏昭, 羽根田祥, 工藤克昌, 森川孝則, 片寄友, 江川新一, 笠島敦子, 海野倫明

    大腸癌研究会プログラム・抄録集　80th　84　2014

  1314. 切除企図胆管癌に対する術前化学放射線療法の安全性‐II相試験25例の検討

    片寄友, 中川圭, 吉田寛, 林洋毅, 森川孝則, 水間正道, 岡田良, 江川新一, 元井冬彦, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　52nd　ROMBUNNO.O73-5　2014

  1315. 当科での急性胆嚢炎手術症例における新旧Tokyoガイドラインの比較

    谷口肇, 阿部友哉, 水間正道, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)　26th　ROMBUNNO.PRS4-4　2014

  1316. 膵体尾部切除術後における膵瘻予測因子の検討

    森川孝則, 元井冬彦, 青木豪, 川口桂, 益田邦洋, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)　26th　ROMBUNNO.ORS5-3　2014

  1317. 膵癌術前化学療法としてのGS(Gemcitabine+S‐1)療法の有効性と安全性の検討

    及川昌也, 元井冬彦, 乙供茂, 岡田恭穂, 島村弘宗, 竹村真一, 小野文徳, 赤田昌紀, 中川圭, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)　26th　ROMBUNNO.PD3-5　2014

  1318. 経過中に発生した急性膵炎を契機に胃穿破を来したと推測される膵管内乳頭粘液性腺癌の1例

    川崎修平, 深瀬耕二, 川口桂, 青木豪, 薮内伸一, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)　26th　ROMBUNNO.P98-5　2014

  1319. 膵全摘と自家膵島移植術後の胆管炎が移植膵島に与える影響―急性閉塞性胆管炎モデルマウスを用いた検討―

    畠達夫, 坂田直昭, 吉松軍平, 土屋朗之, 川口桂, 益田邦洋, 青木豪, 薮内伸一, 深瀬耕二, 水間正道, 林洋毅, 岡田恭穂, 森川孝則, 中川圭, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会学術集会プログラム・抄録集(CD-ROM)　26th　ROMBUNNO.P155-3　2014

  1320. 膵体尾部癌135例の予後因子探索:切除・PET SUVmax値・腫瘍マーカー正常化の意義

    元井冬彦, 川口桂, 益田邦洋, 青木豪, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 森川孝則, 林洋毅, 中川圭, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 片寄友, 江川新一, 江川新一, 海野倫明, 海野倫明

    日本消化器病学会大会(Web)　56th　GEP‐483 (WEB ONLY)　2014

  1321. 膵手術において皮下ドレーン留置は創感染予防に有用か?

    水間正道, 川口桂, 益田邦洋, 岡田良, 薮内伸一, 深瀬耕二, 坂田直昭, 岡田恭穂, 中川圭, 中川圭, 林洋毅, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 片寄友, 江川新一, 海野倫明, 海野倫明, 海野倫明

    日本消化器病学会大会(Web)　56th　GEP‐505 (WEB ONLY)　2014

  1322. 潰瘍性大腸炎術後肛門狭窄に対し、腹腔鏡下に回腸瘻再造設を施行した一例

    長尾 宗紀, 羽根田 祥, 神山 篤史, 工藤 克昌, 大沼 忍, 伊藤 由美, 橘 幸子, 高橋 真紀, 内藤 剛, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　30　(1)　148-148　2014/01

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  1323. A case of a giant solid pseudopapillary neoplasm of the pancreas in a middle-aged man with difficulty in preoperative diagnosis

    ISEKI Masahiro, NAITO Takeshi, KATAYOSE Yu, UNNO Michiaki, MIZUMA Masamichi, SAKATA Naoaki, HAYASHI Hiroki, NAKAGAWA Kei, OKADA Takaho, MORIKAWA Takanori, YOSHIDA Hiroshi, MOTOI Fuyuhiko

    Journal of the Japan Pancreas Society　29　(1)　67-73　2014

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.29.67 　

    ISSN： 0913-0071

    More details Close

    A 47-year-old man presented with continuous epigastric pain and body weight loss. The abdominal CT scan revealed a 21cm encapsulated mass with central necrosis and peripheral calcification in the pancreas. This tumor showed an enhanced solid component in the marginal area. The patient underwent total pancreatectomy with portal vein resection and reconstruction. In the resected specimen, a 26cm tumor of the pancreas, surrounded by a fibrous pseudocapsule, gave rise to central necrosis and intratumoral hemorrhage. Histological examination revealed that the tumor cells with enlarged nucleus and granular eosinophillic cytoplasm were arranged in sheets and nests, forming pseudopapillary structures. They were immunohistologically positive for CD10 and vimentin. Since nuclear accumulation of beta-catenin protein was shown, this tumor was pathologically diagnosed as SPN. SPN of the pancreas is a rare neoplasm and typically afflicts young women. Here we report a case of one of the largest SPNs in Japan, with difficulty in the preoperative diagnosis, arising in a middle-aged man.&lt;br&gt;

  1324. 膵に発生した明細胞腫瘍の1例

    川口 桂, 元井 冬彦, 深瀬 耕二, 笠島 敦子, 菅野 敦, 岡田 尭穂, 坂田 直昭, 中川 圭, 林 洋毅, 吉田 寛, 森川 孝則, 内藤 剛, 片寄 友, 江川 新一, 下瀬川 徹, 海野 倫明

    膵臓　29　(3)　654-654　2014

  1325. 【消化器外科術後合併症の治療】 術後循環不全の診断と治療

    武者 宏昭, 柴田 近, 海野 倫明

    外科　76　(1)　1-5　2014/01

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1326. 肝転移を切除した膵漿液性嚢胞腺癌の1例

    唐澤 秀明, 元井 冬彦, 藪内 伸一, 吉田 寛, 片寄 友, 海野 倫明, 笠島 敦子, 菅野 敦, 下瀬川 徹, 江川 新一

    東北医学雑誌　125　(2)　283-284　2013/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1327. 術前化学療法施行後肝動脈・門脈合併切除でR0切除し得た局所進行膵癌の1例

    川口 桂, 元井 冬彦, 横山 智, 竹村 真一, 土井 孝志, 野沢 佳弘, 藤島 史喜, 海野 倫明, 黒田 房邦

    癌と化学療法　40　(12)　1875-1877　2013/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1328. 切除不能局所進行膵癌に対しR0のアジュバント切除を施行し得た1例

    青木 修一, 水間 正道, 元井 冬彦, 深瀬 耕二, 坂田 直昭, 中川 圭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    癌と化学療法　40　(12)　1868-1871　2013/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1329. 腹腔鏡下肥満外科手術の健全な発展に向けて 当院の肥満外科手術の現状と今後の展望

    田中 直樹, 内藤 剛, 森川 孝則, 土屋 堯裕, 宮地 智洋, 大沼 忍, 佐々木 宏之, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　315-315　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1330. 腹壁瘢痕ヘルニアの腹腔鏡下ヘルニア修復術のエビデンスを問う 腹壁ヘルニアに対する腹腔鏡下手術の有用性

    内藤 剛, 青木 豪, 神山 篤史, 佐々木 宏之, 田中 直樹, 大沼 忍, 武者 宏昭, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　325-325　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1331. 動画映像の管理と配信 オンラインでの手術画像の保存と利用を目的とした手術室統合画像管理システム

    内藤 剛, 青木 豪, 神山 篤史, 佐々木 宏之, 田中 直樹, 大沼 忍, 武者 宏昭, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　335-335　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1332. 腹腔鏡下脾臓摘出術の工夫とトレーニング 当科における腹腔鏡下脾臓摘出術の手順および若手育成

    青木 豪, 森川 孝則, 神山 篤史, 佐々木 宏之, 田中 直樹, 阿部 友哉, 武者 宏昭, 大沼 忍, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　385-385　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1333. 膵臓外科への鏡視下手術導入により、脾温存膵切除術は普及するか?

    森川 孝則, 内藤 剛, 青木 豪, 武者 宏昭, 阿部 友哉, 大沼 忍, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　474-474　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1334. 結腸癌に対する腹腔鏡下結腸切除術における腹部手術既往の影響

    大沼 忍, 内藤 剛, 阿部 友哉, 佐々木 宏之, 神山 篤史, 羽根田 祥, 工藤 克昌, 長尾 宗紀, 青木 豪, 田中 直樹, 武者 宏昭, 森川 孝則, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　490-490　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1335. 腹腔鏡下直腸癌手術におけるDST再建の縫合不全危険因子の検討

    神山 篤史, 内藤 剛, 森川 孝則, 武者 宏昭, 阿部 友哉, 田中 直樹, 大沼 忍, 佐々木 宏之, 吉田 寛, 片寄 友, 青木 豪, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　491-491　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1336. 当院の肥満外科手術成績と今後の展望

    田中 直樹, 内藤 剛, 森川 孝則, 土屋 堯裕, 宮地 智洋, 大沼 忍, 佐々木 宏之, 長尾 宗紀, 阿部 友哉, 武者 宏昭, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　493-493　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1337. 高齢者における腹腔鏡下胃切除の治療成績

    武者 宏昭, 内藤 剛, 工藤 昌克, 田中 直樹, 阿部 友哉, 大沼 忍, 中川 圭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　526-526　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1338. 当科における潰瘍性大腸炎に対するHALS症例の検討と将来の展望

    阿部 友哉, 内藤 剛, 森川 孝則, 大沼 忍, 武者 宏昭, 田中 直樹, 佐々木 宏之, 神山 篤史, 吉田 寛, 林 洋毅, 青木 豪, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　18　(7)　613-613　2013/11

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1339. 直腸神経内分泌腫瘍に対する治療方針

    大沼 忍, 内藤 剛, 羽根田 祥, 工藤 克昌, 神山 篤史, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 青木 豪, 阿部 友哉, 武者 宏昭, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    癌と化学療法　40　(12)　2077-2079　2013/11

    Publisher: (株)癌と化学療法社

    ISSN： 0385-0684

  1340. 胆道再建術既往例に対する肝切除における手術部位感染の検討

    水間正道, 乙供茂, 阿部友哉, 高橋弥生, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本外科感染症学会雑誌　10　(5)　654　2013/10/25

    ISSN： 1349-5755

  1341. 災害医療(保健・福祉を含む)コーディネーター設置の現状と課題

    江川新一, 佐々木宏之, 石井正, 海野倫明

    日本臨床外科学会雑誌　74　330　2013/10/20

    DOI： 10.3919/jjsa.74.330 　

    ISSN： 1345-2843

  1342. Borderline resectable(BR)膵癌における門脈浸潤所見の意義

    川口桂, 元井冬彦, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　74　423　2013/10/20

    ISSN： 1345-2843

  1343. 肝門部胆管癌に対する治療戦略の新展開~術前化学放射線療法のポテンシャル

    水間正道, 片寄友, 吉田寛, 中川圭, 深瀬耕二, 藪内伸一, 乙供茂, 坂田直昭, 林洋毅, 岡田恭穂, 森川孝則, 元井冬彦, 内藤剛, 江川新一, 海野倫明

    日本臨床外科学会雑誌　74　421　2013/10/20

    ISSN： 1345-2843

  1344. Initially unresectable pancreatic cancerに対するNAC・NACRT後adjuvant surgeryの意義

    林洋毅, 元井冬彦, 吉田寛, 森川孝則, 岡田恭穂, 中川圭, 坂田直昭, 水間正道, 乙供茂, 深瀬耕二, 籔内伸一, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　74　425　2013/10/20

    ISSN： 1345-2843

  1345. 切除膵癌におけるPET/CT SUVmax値の意義と術前GS療法の適応

    元井冬彦, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　74　534　2013/10/20

    ISSN： 1345-2843

  1346. 膵全摘後脂肪肝の危険因子についての検討

    畠達夫, 坂田直昭, 青木豪, 岡田恭穂, 水間正道, 中川圭, 乙供茂, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　74　768　2013/10/20

    ISSN： 1345-2843

  1347. 胆道癌術後再発症例に対する手術成績の検討

    工藤克昌, 林洋毅, 元井冬彦, 吉田寛, 森川孝則, 岡田恭穂, 中川圭, 坂田直昭, 水間正道, 深瀬耕二, 内藤剛, 片寄友, 江川新一, 柴田近, 海野倫明

    日本臨床外科学会雑誌　74　366　2013/10/20

    ISSN： 1345-2843

  1348. MDCTを用いた膵癌の動脈周囲神経叢進展の評価

    青木 修一, 元井 冬彦, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 坂田 直昭, 乙供 茂, 深瀬 耕二, 藪内 伸一, 青木 豪, 川口 桂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　324-324　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1349. Multiple endocrine neoplasia type 1(MEN-1)に伴うガストリノーマの外科治療

    柴田 近, 森川 孝則, 大塚 英郎, 長尾 宗紀, 田中 直樹, 羽根田 祥, 大沼 忍, 工藤 克昌, 佐々木 宏之, 神山 篤史, 鹿郷 昌之, 小川 仁, 内藤 剛, 三浦 康, 青木 豪, 吉田 寛, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　329-329　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1350. 年齢と併存疾患からみた腹腔鏡補助下胃切除術の周術期成績

    田中 直樹, 鹿郷 昌之, 柴田 近, 工藤 克昌, 神山 篤史, 大沼 忍, 佐々木 宏之, 長尾 宗紀, 森川 孝則, 小川 仁, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　46　(Suppl.2)　344-344　2013/10

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1351. 膵IPMNの手術適応と術式 過去の手術症例の術式・膵切除断端・多中心性所見からみたIPMNの最適術式と経過観察法についての検討

    岡田 恭穂, 水間 正道, 川口 桂, 藪内 伸一, 深瀬 耕二, 乙供 茂, 坂田 直昭, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　390-390　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1352. 肝細胞癌術後孤立性膵頭後部リンパ節転移再発の1例

    谷口 肇, 水間 正道, 岡田 恭穂, 川口 桂, 工藤 克昌, 藪内 伸一, 坂田 直昭, 森川 孝則, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　865-865　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1353. 当科における慢性偽性腸閉塞症手術例3例の検討

    長尾宗紀, 柴田近, 田中直樹, 佐々木宏之, 阿部友哉, 羽根田祥, 大沼忍, 工藤克昌, 神山篤史, 武者宏昭, 林洋毅, 岡田恭穂, 中川圭, 森川孝則, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本神経消化器病学会プログラム・抄録集　15th　25　2013/10

  1354. 当科での腹腔鏡下大腸切除におけるSSIの検討

    阿部 友哉, 羽根田 祥, 大沼 忍, 神山 篤史, 佐々木 宏之, 水間 正道, 吉田 寛, 内藤 剛, 柴田 近, 海野 倫明

    日本外科感染症学会雑誌　10　(5)　685-685　2013/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  1355. 局所進行膵癌の治療戦略 膵癌術前治療による組織学的治療効果と画像上の変化 adjuvant切除の適応は画像所見で判断できるか?

    青木 修一, 水間 正道, 元井 冬彦, 阿部 友哉, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 坂田 直昭, 乙供 茂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　362-362　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1356. 内視鏡下膵切除術の手術手技 腹腔鏡下膵切除術における脾動静脈温存膵体尾部切除術の意義

    森川 孝則, 内藤 剛, 青木 豪, 武者 宏昭, 阿部 友哉, 大沼 忍, 坂田 直昭, 中川 圭, 岡田 恭穂, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　353-353　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1357. 腹腔鏡補助下噴門側胃切除の治療成績

    武者 宏昭, 内藤 剛, 工藤 克昌, 田中 直樹, 阿部 友哉, 大沼 忍, 中川 圭, 岡田 恭穂, 林 洋毅, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　496-496　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1358. 5-FU投与患者におけるジヒドロピリミジンデヒドロゲナーゼ遺伝子多型とその表現型の解析(Analysis of the single nucleotide polymorphisms of the DPYD gene that affect adverse events in 5-FU treated patients)

    戸嶋 政秀, 大沼 忍, 三浦 康, 田中 道廣, 武者 宏昭, 羽根田 祥, 工藤 克昌, 神山 篤史, 長尾 宗紀, 内藤 剛, 片寄 友, 柴田 近, 海野 倫明

    日本癌学会総会記事　72回　193-193　2013/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1359. 経口フッ化ピリミジン製剤S-1投与にもとづく腸管および全身免疫の評価と臨床への応用(Evaluation of gut and systemic immunity under the oral administration of S-1 and its clinical application)

    梶原 大輝, 大沼 忍, 三浦 康, 武者 宏昭, 羽根田 祥, 工藤 克昌, 神山 篤史, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 白坂 哲彦, 海野 倫明

    日本癌学会総会記事　72回　369-369　2013/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1360. ヒト大腸癌細胞株皮下移植マウスモデルを用いたS-1/LV隔日投与法の抗腫瘍効果・有害事象の検討(Alternate-day treatment with S-1/LV in a xenograft mouse model of colorectal cancer)

    小村 俊博, 三浦 康, 大沼 忍, 武者 宏昭, 羽根田 祥, 工藤 克昌, 神山 篤史, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明, 白坂 哲彦

    日本癌学会総会記事　72回　399-399　2013/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1361. 自己免疫性膵炎類似の間質所見を呈した膵尾部癌の1例

    中野 絵里子, 菅野 敦, 正宗 淳, 三浦 晋, 滝川 哲也, 有賀 啓之, 海野 純, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 坂田 直昭, 元井 冬彦, 江川 新一, 海野 倫明, 藤島 史喜, 石田 和之, 下瀬川 徹

    膵臓　28　(5)　627-635　2013/10

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1362. 胆石症として手術された胆嚢癌の治療方針 胆石症として初回手術を受けた胆嚢癌症例の検討

    唐澤 秀明, 林 洋毅, 薮内 伸一, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 森川 孝則, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　74　(増刊)　394-394　2013/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1363. 膵がん治療の新たな展開 膵がんに対する術前化学療法の意義

    元井冬彦, 片寄友, 江川新一, 海野倫明

    月刊腫瘍内科　12　(3)　252-258　2013/09/28

    ISSN： 1881-6568

  1364. Transplant Efficacy: Understanding the Effectiveness of Islet Transplantation.

    Haruyuki Tsuchiya, Naoaki Sakata, Takeshi Aoki, Gumpei Yoshimatsu, Tatsuo Hata, Fuyuhiko Motoi, Yu Katayose, Shinichi Egawa, Michiaki Unno

    TRANSPLANTATION　96　(6)　S132-S132　2013/09

    ISSN： 0041-1337

    eISSN： 1534-6080

  1365. Imaging of Transplanted Islets by Ultrasonography

    Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Takeshi Aoki, Masamichi Mizuma, Fuyuhiko Motoi, Yu Katayose, Tetsuya Kodama, Michiaki Unno

    TRANSPLANTATION　96　(6)　S126-S126　2013/09

    ISSN： 0041-1337

    eISSN： 1534-6080

  1366. Intramuscular Co-Transplantation of Islets and Bone Marrow Derived Mesenchymal Stem Cells in Rodent Model

    Gumpei Yoshimatsu, Naoaki Sakata, Takeshi Aoki, Haruyuki Tsuchiya, Tatsuo Hata, Masahiko Fukase, Fuyuhiko Motoi, Yu Katayose, Shinichi Egawa, Michiaki Unno

    TRANSPLANTATION　96　(6)　S150-S150　2013/09

    ISSN： 0041-1337

    eISSN： 1534-6080

  1367. Mutant GNAS found in IPMN can alter global gene expressions with mucin upregulation

    H. Komatsu, N. Sakata, T. Aoki, F. Motoi, T. Naitoh, Y. Katayose, S. Egawa, M. Unno, T. Furukawa

    EUROPEAN JOURNAL OF CANCER　49　S580-S580　2013/09

    ISSN： 0959-8049

    eISSN： 1879-0852

  1368. 大腸カルチノイドとGISTの治療戦略 直腸GISTの治療戦略

    大沼 忍, 内藤 剛, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 神山 篤史, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　66　(9)　698-698　2013/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1369. 当院でのクローン病に対する外科治療の成績

    羽根田 祥, 長尾 宗紀, 大沼 忍, 佐々木 宏之, 工藤 克昌, 神山 篤史, 内藤 剛, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　66　(9)　758-758　2013/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1370. 重症潰瘍性大腸炎症例に対する外科治療の成績

    神山 篤史, 羽根田 祥, 柴田 近, 内藤 剛, 長尾 宗紀, 大沼 忍, 工藤 克昌, 佐々木 宏之, 舟山 裕士, 高橋 賢一, 海野 倫明

    日本大腸肛門病学会雑誌　66　(9)　762-762　2013/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1371. 潰瘍性大腸炎に対する回腸肛門吻合術後の長期予後の検討

    長尾 宗紀, 羽根田 祥, 佐々木 宏之, 大沼 忍, 工藤 克昌, 神山 篤史, 内藤 剛, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　66　(9)　764-764　2013/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1372. 癌化したクローン病14症例の外科的側面からの検討

    神山 篤史, 高橋 賢一, 羽根田 祥, 柴田 近, 内藤 剛, 小川 仁, 長尾 宗紀, 大沼 忍, 志賀 永嗣, 遠藤 克哉, 高橋 成一, 木内 嘉孝, 三浦 康, 森川 孝則, 田中 直樹, 佐々木 宏之, 片寄 友, 江川 新一, 舟山 裕士, 海野 倫明

    日本消化器病学会雑誌　110　(臨増大会)　A924-A924　2013/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1373. Stage IV大腸癌手術例における長期生存例の特徴

    大沼 忍, 内藤 剛, 阿部 友哉, 長尾 宗紀, 羽根田 祥, 佐々木 宏之, 神山 篤史, 片寄 友, 柴田 近, 海野 倫明

    日本癌治療学会誌　48　(3)　1259-1259　2013/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1374. 【各種デバイスを応用した私の手術-使用法と工夫】 各種デバイスを応用した膵手術 鏡視下手術を中心に

    森川 孝則, 内藤 剛, 元井 冬彦, 青木 豪, 海野 倫明

    外科　75　(9)　960-964　2013/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1375. 大腸癌細胞株移植マウスモデルを用いたS-1/LV隔日投与法の抗腫瘍効果・有害事象の検討

    小村 俊博, 三浦 康, 大沼 忍, 武者 宏昭, 羽根田 祥, 工藤 克昌, 神山 篤史, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 海野 倫明, 白坂 哲彦

    日本癌治療学会誌　48　(3)　1913-1913　2013/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1376. 十二指腸乳頭部原発腺内分泌細胞癌の1例

    中野 絵里子, 菅野 敦, 正宗 淳, 三浦 晋, 廣田 衛久, 岡田 恭穂, 吉田 寛, 片寄 友, 海野 倫明, 下瀬川 徹

    胆道　27　(3)　535-535　2013/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1377. Staging of gallbladder cancer

    Atsushi Kanno, Atsushi Masamune, Hiroki Hayashi, Michiaki Unno, Tooru Shimosegawa

    Journal of Japanese Society of Gastroenterology　110　(8)　1400-1407　2013/08

    DOI： 10.11405/nisshoshi.110.1400 　

    ISSN： 0446-6586

  1378. MDCTによる尾状葉門脈/胆管枝の走行形態の検討

    青木 修一, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 阿部 友哉, 森川 孝則, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    胆道　27　(3)　493-493　2013/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1379. LC-MS/MS蛋白質絶対定量法による膵癌薬物代謝酵素群発現量測定とゲムシタビンの効果予測への応用

    大塚 英郎, 川口 桂, 井上 亨悦, 深瀬 耕二, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 寺崎 哲也, 海野 倫明

    日本消化器外科学会総会　68回　O-67　2013/07

    Publisher: (一社)日本消化器外科学会

  1380. 遠隔地にある臨床研修病院への「出張スキルスラボ」の試み

    田畑 雅央, 水間 正道, 門馬 靖武, 松田 綾音, 星 達也, 安海 清, 海野 倫明, 石井 正, 下瀬川 徹, 金塚 完, 加賀谷 豊

    医学教育　44　(Suppl.)　77-77　2013/07

    Publisher: 日本医学教育学会

    ISSN： 0386-9644

  1381. 腹腔鏡下スリーブバイパス術の体重減少効果および糖尿病改善効果

    内藤 剛, 田中 直樹, 宮地 智洋, 森川 孝則, 元井 冬彦, 片寄 友, 三浦 康, 柴田 近, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　RV-13　2013/07

    Publisher: (一社)日本消化器外科学会

  1382. 結腸内TRPA1 agonist投与による結腸運動亢進・排便誘発作用の検討

    染谷 崇徳, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 小川 仁, 内藤 剛, 三浦 康, 柴田 近, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　P-144　2013/07

    Publisher: (一社)日本消化器外科学会

  1383. 当科における大腸癌肺転移症例の検討

    佐々木 宏之, 三浦 康, 大沼 忍, 内藤 剛, 小川 仁, 長尾 宗紀, 田中 直樹, 柴田 近, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　P-161　2013/07

    Publisher: (一社)日本消化器外科学会

  1384. 潰瘍性大腸炎に合併した大腸癌に対する術式選択の検討

    神山 篤史, 小川 仁, 柴田 近, 三浦 康, 内藤 剛, 羽根田 祥, 舟山 裕士, 高橋 賢一, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　RS-25　2013/07

    Publisher: (一社)日本消化器外科学会

  1385. 経口フッ化ピリミジン製剤S-1投与にもとづく腸管および全身免疫の評価と臨床への応用

    梶原 大輝, 三浦 康, 大沼 忍, 羽根田 祥, 工藤 克昌, 神山 篤史, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　P-121　2013/07

    Publisher: (一社)日本消化器外科学会

  1386. 臓器・細胞移植医療の現状と展望 間葉系幹細胞は膵島移植成績を向上させる光となるか

    坂田 直昭, 吉松 軍平, 土屋 朗之, 畠 達夫, 深瀬 正彦, 青木 豪, 石田 晶玄, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器外科学会総会　68回　WS-9　2013/07

    Publisher: (一社)日本消化器外科学会

  1387. 大腸癌根治術後の肺転移の危険因子及び根治的肺切除術後の予後因子についての検討 TNM分類の先を目指して

    渡辺 和宏, 齋藤 典男, 杉藤 正典, 伊藤 雅昭, 小林 昭広, 西澤 雄介, 三浦 康, 内藤 剛, 柴田 近, 海野 倫明

    日本消化器外科学会総会　68回　P-161　2013/07

    Publisher: (一社)日本消化器外科学会

  1388. 膵切除後の短期・長期合併症に対する予防策とその根拠 膵頭十二指腸切除後膵瘻の予測因子としての膵実質ADC値の有用性 膵ADC値がpancreatic textureを反映する

    青木 修一, 元井 冬彦, 水間 正道, 岡田 恭穂, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　68回　SY-10　2013/07

    Publisher: (一社)日本消化器外科学会

  1389. 膵・消化管神経内分泌腫瘍、特にガストリノーマにおけるグルカゴン受容体の発現

    柴田 近, 笠島 敦子, 三浦 康, 内藤 剛, 小川 仁, 森川 孝則, 元井 冬彦, 江川 新一, 笹野 公伸, 海野 倫明

    日本消化器外科学会総会　68回　P-49　2013/07

    Publisher: (一社)日本消化器外科学会

  1390. 胃癌手術症例における術後の栄養評価と体重減少の検討

    工藤 克昌, 柴田 近, 武者 宏昭, 大沼 忍, 羽根田 祥, 神山 篤史, 田中 直樹, 阿部 友哉, 森川 孝則, 長尾 宗紀, 佐々木 宏之, 内藤 剛, 海野 倫明

    胃病態機能研究会誌　45　40-40　2013/07

    Publisher: (株)勁草書房コミュニケーション事業部

    ISSN： 1880-3652

  1391. 膵胆道癌の手術と補助療法

    江川新一, 片寄友, 海野倫明

    東北医学雑誌　125　(1)　48-53　2013/06/25

    ISSN： 0040-8700

  1392. ゲムシタビン感受性と相関を示す代謝系の特定:感受性バイオマーカーとしての可能性

    齋木由利子, 砂村眞琴, 糸井隆夫, 島津元秀, 河地茂行, 元井冬彦, 江川新一, 海野倫明, 杉本昌弘, 堀井明

    すい臓　28　(3)　424　2013/06/10

    ISSN： 0913-0071

  1393. 当科における多発性内分泌腫瘍症1型(MEN)に伴う膵神経内分泌腫瘍の検討

    片桐宗利, 森川孝則, 乙供茂, 岡田恭穂, 林洋毅, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    すい臓　28　(3)　381　2013/06/10

    ISSN： 0913-0071

  1394. 腹部大動脈周囲リンパ節転移を有する膵癌の切除意義

    水間正道, 元井冬彦, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 乙供茂, 坂田直昭, 大塚英郎, 深瀬耕二, 藪内伸一, 青木豪, 川口桂, 吉田寛, 内藤剛, 片寄友, 江川新一, 菅野敦, 下瀬川徹, 海野倫明

    すい臓　28　(3)　392　2013/06/10

    ISSN： 0913-0071

  1395. 切除企図膵癌に対する術前GS療法による治療戦略

    元井冬彦, 川口桂, 青木豪, 薮内伸一, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 菅野敦, 下瀬川徹, 海野倫明

    すい臓　28　(3)　302　2013/06/10

    ISSN： 0913-0071

  1396. 膵管内乳頭粘液性腫瘍において見出された変異GNASはMucin遺伝子発現を促進する

    小松弘武, 坂田直昭, 青木豪, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明, 古川徹

    すい臓　28　(3)　449　2013/06/10

    ISSN： 0913-0071

  1397. 胃切除後膵切除 (特集 肝胆膵外科における再切除と再手術)

    深瀬 耕二, 元井 冬彦, 海野 倫明

    手術 = Operation　67　(7)　1061-1066　2013/06

    Publisher: 金原出版

    ISSN： 0037-4423

  1398. 大腸癌膵転移への外科的切除の意義

    佐藤 好宏, 深瀬 耕二, 青木 豪, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 菅野 敦, 正宗 淳, 下瀬川 徹, 海野 倫明

    膵臓　28　(3)　443-443　2013/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1399. Ileal transpositionとDuodeno-Jejunal bypassの糖尿病改善効果とその臨床応用

    内藤 剛, 生澤 史江, 井本 博文, 宮地 智洋, 田中 直樹, 森川 孝則, 吉田 寛, 乙供 茂, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　31回　38-38　2013/06

    Publisher: 日本肥満症治療学会

  1400. 肥満症の診療 集学的治療の確立・普及を目指して 当院の病的肥満症に対する減量手術の安全性と有効性

    田中 直樹, 内藤 剛, 森川 孝則, 土屋 堯裕, 宮地 智洋, 長尾 宗紀, 石垣 泰, 武田 みゆき, 岡本 智子, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　31回　52-52　2013/06

    Publisher: 日本肥満症治療学会

  1401. Duodenojejunal bypassにおいて、alimentary limbおよびbiliopancreatic limbの長さが糖尿病改善効果に与える影響 2型糖尿病モデルラットでの検討

    宮地 智洋, 柴田 近, 田中 直樹, 内藤 剛, 海野 倫明

    日本肥満症治療学会学術集会プログラム・抄録集　31回　110-110　2013/06

    Publisher: 日本肥満症治療学会

  1402. 当科における大腸癌肺転移症例の検討

    佐々木 宏之, 三浦 康, 大沼 忍, 内藤 剛, 小川 仁, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 羽根田 祥, 工藤 克昌, 神山 篤史, 片寄 友, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　66　(6)　468-468　2013/06

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1403. 膵切除術後膵瘻の予測因子としての膵実質ADC値の有用性

    青木 修一, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 坂田 直昭, 乙供 茂, 深瀬 耕二, 藪内 伸一, 青木 豪, 川口 桂, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25回　550-550　2013/06

    Publisher: (一社)日本肝胆膵外科学会

  1404. 質的診断としてのFDG-PETおよびDWI-MRIの有効性 膵癌外科的切除例からの検討

    青木 修一, 元井 冬彦, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 坂田 直昭, 乙供 茂, 深瀬 耕二, 青木 豪, 吉田 寛, 内藤 剛, 片寄 友, 江川 新一, 菅野 敦, 下瀬川 徹, 海野 倫明

    膵臓　28　(3)　402-402　2013/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1405. ガストリノーマにおけるグルカゴン受容体の発現とグルカゴン負荷試験

    柴田 近, 笠島 敦子, 三浦 康, 内藤 剛, 鹿郷 昌之, 森川 孝則, 大塚 英郎, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 笹野 公伸, 江川 新一, 海野 倫明

    膵臓　28　(3)　377-377　2013/06

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1406. 肝転移を伴う膵神経内分泌腫瘍の治療方針

    江川新一, 元井冬彦, 青木豪, 海野倫明

    日本内分泌外科学会総会プログラム・抄録集　25th　66　2013/05

  1407. pNETに対する化学療法:エベロリムス使用例の検討

    青木豪, 坂田直昭, 乙供茂, 大塚英郎, 中川圭, 岡田恭穂, 森川孝則, 林洋毅, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本内分泌外科学会総会プログラム・抄録集　25th　64　2013/05

  1408. 家族性大腸腺腫症合併胃癌の臨床病理学的特徴

    柴田 近, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 工藤 克昌, 小川 仁, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 神山 篤史, 森川 孝則, 大塚 英郎, 海野 倫明

    日本外科系連合学会誌　38　(3)　674-674　2013/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

  1409. 【炎症性腸疾患2013】 炎症性腸疾患の経過 潰瘍性大腸炎の術後経過

    渡辺 和宏, 柴田 近, 小川 仁, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 神山 篤史, 鈴木 秀幸, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 大沼 忍, 佐々木 宏之, 海野 倫明, 福島 浩平

    胃と腸　48　(5)　731-736　2013/05

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1403113817 　

    ISSN： 0536-2180

  1410. 【肝門部胆管癌の治療戦略2013】 肝門部胆管癌に対する術式選択の理論と実際

    吉田 寛, 片寄 友, 内藤 剛, 元井 冬彦, 岡田 恭穂, 森川 孝則, 林 洋毅, 海野 倫明

    外科　75　(5)　479-485　2013/05

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1411. 高齢者大腸癌の化学療法 当科における投薬状況

    大沼 忍, 三浦 康, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗則, 田中 直樹, 羽根田 祥, 佐々木 宏之, 工藤 克昌, 尾崎 芙実, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　66　(4)　301-301　2013/04

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1412. 新人ナース必携!消化器のしくみがわかる・術後の変化がわかる 解剖生理カラービジュアルブック 臓器別 解剖生理 8 膵臓

    青木豪, 海野倫明

    消化器外科Nursing　18　(4)　341-344　2013/04/01

    ISSN： 1341-7819

  1413. 膵消化管神経内分泌腫瘍における免疫組織学的な治療標的分子の発現状況

    笠島 敦子, 櫻井 友貴, 高橋 弥生, 深谷 佐智子, 佐藤 直実, 佐藤 聡子, 谷内 真司, 藤島 史喜, 中村 保宏, 渡辺 みか, 海野 倫明, 笹野 公伸

    日本病理学会会誌　102　(1)　320-320　2013/04

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  1414. 確定診断に苦慮した若年発症神経内分泌腫瘍の1例

    鈴木亨, 長谷川豊, 吉田寛, 江川新一, 渡辺みか, 海野倫明, 笹野公伸, 山田哲也, 石垣泰, 岡芳知, 片桐秀樹

    糖尿病　56　(3)　209　2013/03/30

    ISSN： 0021-437X

  1415. PS-107-2 Dorsal liverにおける門脈胆管枝の立体解剖 : MDCTにもとづく解析(PS ポスターセッション,第113回日本外科学会定期学術集会)

    青木 修一, 水間 正道, 吉田 寛, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 乙供 茂, 坂田 直昭, 深瀬 耕二, 青木 豪, 元井 冬彦, 内藤 剛, 三浦 康, 柴田 近, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(2)　668-668　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1416. PS-113-2 γセクレターゼ阻害剤MRK-003はヒト臨床検体移植マウスモデルにおいて膵癌の増殖を抑制する(PS ポスターセッション,第113回日本外科学会定期学術集会)

    水間 正道, 藪内 伸一, 大村 範幸, 海野 倫明, Maitra Anirban, Rajeshkumar N.V

    日本外科学会雑誌　114　(2)　677-677　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1417. PS-070-4 新規RhoA調節蛋白GCF2/LRRFIP1による大腸癌浸潤転移制御の可能性(PS ポスターセッション,第113回日本外科学会定期学術集会)

    大塚 英郎, 有明 恭平, 堂地 大輔, 元井 冬彦, 深瀬 耕二, 青木 豪, 乙供 茂, 水間 正道, 坂田 直昭, 中川 圭, 林 洋毅, 森川 孝則, 岡田 恭穂, 吉田 寛, 鹿郷 昌之, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　617-617　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1418. PS-366-5 通常型膵癌における腫瘍マーカーとしての血清抗p53抗体の測定意義(PS ポスターセッション,第113回日本外科学会定期学術集会)

    畠 達夫, 坂田 直昭, 青木 豪, 深瀬 耕二, 大塚 英郎, 乙供 茂, 水間 正道, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(2)　1034-1034　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1419. PS-383-5 移植膵島の超音波画像(PS ポスターセッション,第113回日本外科学会定期学術集会)

    坂田 直昭, 後藤 昌史, 小玉 哲也, 元井 冬彦, 水間 正道, 吉松 軍平, 青木 豪, 深瀬 耕二, 大塚 英郎, 乙供 茂, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 内藤 剛, 三浦 康, 片寄 友, 里見 進, 海野 倫明

    日本外科学会雑誌　114　(2)　1058-1058　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1420. PS-186-5 型糖尿病は手術で「治す」(PS ポスターセッション,第113回日本外科学会定期学術集会)

    田中 直樹, 内藤 剛, 柴田 近, 井本 博文, 宮地 智洋, 森川 孝則, 鹿郷 昌之, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 三浦 康, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(2)　779-779　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1421. PS-186-3 当院における肥満手術後の体重減少効果の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    宮地 智洋, 田中 直樹, 内藤 剛, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　779-779　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1422. PS-228-2 膵頭十二指腸切除術後,動脈性出血に対する治療戦略(PS ポスターセッション,第113回日本外科学会定期学術集会)

    深瀬 耕二, 青木 豪, 大塚 英郎, 乙供 茂, 水間 正道, 坂田 直昭, 中川 圭, 岡田 恭穂, 森川 孝則, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　839-839　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1423. PS-356-2 膵島移植における安全な移植部位の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    土屋 朗之, 坂田 直昭, 吉松 軍平, 青木 豪, 水間 正道, 深瀬 耕二, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　1019-1019　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1424. PS-376-3 cIAP2を標的とする消化器癌の新規治療戦略の提案(PS ポスターセッション,第113回日本外科学会定期学術集会)

    三浦 康, 唐澤 秀明, 藤渕 航, 石田 和之, 柴田 近, 内藤 剛, 小川 仁, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 工藤 克昌, 鹿郷 昌之, 森川 孝則, 田中 直樹, 片寄 友, 元井 冬彦, 吉田 寛, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1425. 広範囲胆管癌の標準術式:左葉切除尾状葉切除兼膵頭十二指腸切除術(HPD)

    片寄友, 林洋毅, 中川圭, 元井冬彦, 吉田寛, 森川孝則, 岡田恭穂, 水間正道, 大塚英郎, 乙供茂, 坂田直昭, 深瀬耕二, 青木豪, 三浦康, 内藤剛, 柴田近, 江川新一, 海野倫明

    日本外科学会雑誌　114　426　2013/03/05

    ISSN： 0301-4894

  1426. 膵管径に応じた膵管外瘻ステントの留置による,膵瘻減少を目指した膵腸吻合:無作為比較試験の結果に立脚して

    元井冬彦, 青木豪, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 三浦康, 片寄友, 柴田近, 江川新一, 海野倫明

    日本外科学会雑誌　114　207　2013/03/05

    ISSN： 0301-4894

  1427. 超高齢者に膵頭十二指腸切除術を適用する際のリスクファクターは何か?

    岡田恭穂, 元井冬彦, 青木豪, 深瀬耕二, 乙供茂, 坂田直昭, 大塚英郎, 水間正道, 林洋毅, 中川圭, 森川孝則, 吉田寛, 内藤剛, 三浦康, 片寄友, 柴田近, 江川新一, 海野倫明

    日本外科学会雑誌　114　1018　2013/03/05

    ISSN： 0301-4894

  1428. 蛍光NOGマウスの異種移植モデルを用いた高純度癌細胞サンプリングシステム

    嶋健太郎, 水間正道, 林洋毅, 中川圭, 岡田恭穂, 坂田直昭, 大村範幸, 北村洋, 吉田寛, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 石井直人, 堀井明, 海野倫明

    日本外科学会雑誌　114　1061　2013/03/05

    ISSN： 0301-4894

  1429. 膵管内乳頭粘液性腫瘍において見出された変異GNASの機能解析

    小松弘武, 坂田直昭, 青木豪, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明, 古川徹

    日本外科学会雑誌　114　410　2013/03/05

    ISSN： 0301-4894

  1430. 当科におけるpNETの治療方針と手術術式選択のストラテジー

    青木豪, 坂田直昭, 深瀬耕二, 水間正道, 乙供茂, 大塚英郎, 岡田恭穂, 中川圭, 森川孝則, 林洋毅, 鹿郷昌之, 元井冬彦, 内藤剛, 三浦康, 片寄友, 柴田近, 江川新一, 海野倫明

    日本外科学会雑誌　114　830　2013/03/05

    ISSN： 0301-4894

  1431. SY-13-3 MDCTからみた肝門部動門脈解剖 : 左側からの肝切除で把握すべき分岐形態(SY シンポジウム,第113回日本外科学会定期学術集会)

    吉田 寛, 青木 修一, 林 洋毅, 中川 圭, 森川 孝則, 岡田 恭穂, 大塚 英郎, 乙供 茂, 水間 正道, 坂田 直昭, 深瀬 耕二, 青木 豪, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1432. VSY-14-1 膵管径に応じた膵管外痩ステントの留置による,膵痩減少を目指した膵腸吻合:無作為比較試験の結果に立脚して(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)

    元井 冬彦, 青木 豪, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 森川 孝則, 林洋 毅, 中川 圭, 岡田 恭穂, 吉田 寛, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1433. YT-8-5(YRA) 膵管内乳頭粘液性腫瘍において見出された変異GNASの機能解析(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会)

    小松 弘武, 坂田 直昭, 青木 豪, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明, 古川 徹

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1434. VF-007-1 広範囲胆管癌の標準術式 : 左葉切除尾状葉切除兼膵頭十二指腸切除術(HPD)(VF ビデオフォーラム,第113回日本外科学会定期学術集会)

    片寄 友, 林 洋毅, 中川 圭, 元井 冬彦, 吉田 寛, 森川 孝則, 岡田 恭穂, 水間 正道, 大塚 英郎, 乙供 茂, 坂田 直昭, 深瀬 耕二, 青木 豪, 三浦 康, 内藤 剛, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1435. VF-009-1 保険収載後の腹腔鏡下膵切除術 : 安全な普及を目指して(VF ビデオフォーラム,第113回日本外科学会定期学術集会)

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 大沼 忍, 工藤 昌克, 青木 豪, 深瀬 耕二, 乙供 茂, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1436. PS-222-4 当科におけるpNETの治療方針と手術術式選択のストラテジー(PS ポスターセッション,第113回日本外科学会定期学術集会)

    青木 豪, 坂田 直昭, 深瀬 耕二, 水間 正道, 乙供 茂, 大塚 英郎, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1437. PS-330-3 結腸内寒冷受容体刺激による結腸運動充進・排便誘発作用の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    染谷 崇徳, 柴田 近, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 宮地 智洋, 菊池 大介, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1438. PS-355-3 超高齢者に膵頭十二指腸切除術を適用する際のリスクファクターは何か?(PS ポスターセッション,第113回日本外科学会定期学術集会)

    岡田 恭穂, 元井 冬彦, 青木 豪, 深瀬 耕二, 乙供 茂, 坂田 直昭, 大塚 英郎, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 吉田 寛, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1439. PS-385-4 蛍光NOGマウスの異種移植モデルを用いた高純度癌細胞サンプリングシステム(PS ポスターセッション,第113回日本外科学会定期学術集会)

    嶋 健太郎, 水間 正道, 林 洋毅, 中川 圭, 岡田 恭穂, 坂田 直昭, 大村 範幸, 北村 洋, 吉田 寛, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 石井 直人, 堀井 明, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1440. VSY-8-1 腹腔鏡下結腸切除術習得におけるCo-Axial setting theoryに基づいたポートセッティングの有用性(VSY ビデオシンポジウム,第113回日本外科学会定期学術集会)

    内藤 剛, 大沼 忍, 佐々木 宏之, 三浦 康, 鹿郷 昌之, 森川 孝則, 田中 直樹, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 元井 冬彦, 吉田 寛, 林 洋毅, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1441. WS-19-1 大建申湯胃内投与の結腸運動充進効果におけるTRPV1の関与(WS ワークショップ,第113回日本外科学会定期学術集会)

    柴田 近, 菊地 大介, 井本 博文, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 羽根田 祥, 長尾 宗紀, 大沼 忍, 工藤 克昌, 佐々木 宏之, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1442. PS-060-4 大腸癌invivoマウスモデルによるS-1/LV連日・隔日投与法の評価と病理学的検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    小村 俊博, 工藤 克昌, 大沼 忍, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 海野 倫明, 白坂 哲彦

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1443. PS-065-4 フローサイトメトリーを用いた大腸癌腫瘍浸潤リンパ球の表面抗原解析およびサイトカイン産生能解析(PS ポスターセッション,第113回日本外科学会定期学術集会)

    木内 誠, 三浦 康, 大沼 忍, 佐々木 宏之, 田中 直樹, 鹿郷 昌之, 内藤 剛, 羽根田 祥, 工藤 克昌, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1444. PS-071-6 ヒト大腸癌細胞株マウス同所移植モデルを用いた上皮間葉転換及び転移カスケードの解析(PS ポスターセッション,第113回日本外科学会定期学術集会)

    松田 泰史, 三浦 康, 石田 和之, 藤渕 航, 佐々木 宏之, 大沼 忍, 工藤 克昌, 羽田 祥, 長尾 宗紀, 田中 直樹, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1445. PS-179-2 腸管内分泌細胞におけるIL-23の機能とクローン病との関連性(PS ポスターセッション,第113回日本外科学会定期学術集会)

    鈴木 秀幸, 小川 仁, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 大沼 忍, 工藤 克昌, 羽根田 祥, 柴田 近, Kidd Mark, Brenna Oystein, Gustafsson Bjorn, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1446. PS-193-3 クローン病における吻合法別の再手術率の検討 : 端々吻合v.s機能的端々吻合(PS ポスターセッション,第113回日本外科学会定期学術集会)

    羽根田 祥, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 工藤 克昌, 大沼 忍, 佐々木 宏之, 元井 冬彦, 吉田 寛, 片寄 友, 三浦 康, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1447. PS-193-6 潰瘍性大腸炎に対する回腸肛門(管)吻合術終了後の人工肛門再造設症例の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    長尾 宗紀, 柴田 近, 羽根田 祥, 小川 仁, 田中 直樹, 工藤 克昌, 佐々木 宏之, 大沼 忍, 森川 孝則, 鹿郷 昌之, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1448. PS-197-1 直腸カルチノイド手術症例の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    大沼 忍, 三浦 康, 内藤 剛, 羽根田 祥, 工藤 克昌, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鹿郷 昌之, 森川 孝則, 鈴木 秀幸, 梶原 大輝, 戸嶋 政秀, 小村 俊博, 松田 泰史, 染谷 崇徳, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1449. PS-306-2 癌手術症例における術後のCONUT法による栄養評価の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)

    工藤 克昌, 柴田 近, 大沼 忍, 羽根田 祥, 梶原 大輝, 小村 俊博, 戸嶋 政秀, 三浦 康, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鈴木 秀幸, 松田 泰史, 染谷 崇徳, 片寄 友, 元井 冬彦, 吉田 寛, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1450. PS-375-6 5-FU投与患者におけるジヒドロピリミジンデヒドロゲナーゼ遺伝子多型と,その表現型との解析(PS ポスターセッション,第113回日本外科学会定期学術集会)

    戸嶋 政秀, 大沼 忍, 工藤 克昌, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1451. PS-376-3 cIAP2を標的とする消化器癌の新規治療戦略の提案(PS ポスターセッション,第113回日本外科学会定期学術集会)

    三浦 康, 唐澤 秀明, 藤渕 航, 石田 和之, 柴田 近, 内藤 剛, 小川 仁, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 工藤 克昌, 鹿郷 昌之, 森川 孝則, 田中 直樹, 片寄 友, 元井 冬彦, 吉田 寛, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(2)　2013/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 1880-1129

  1452. 反応性低血糖で診断され、グリコース応答性インスリン分泌が保たれたインスリノーマの1例

    宗像 佑一郎, 宇野 健司, 高橋 圭, 浅井 洋一郎, 田中 満実子, 今井 淳太, 山田 哲也, 石垣 泰, 海野 倫明, 岡 芳知, 片桐 秀樹

    糖尿病　56　(3)　208-208　2013/03

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

    eISSN： 1881-588X

  1453. 腹腔鏡下幽門側胃切除術における工夫 リンパ節郭清と再建 腹腔鏡下結腸切除術習得におけるCo-Axial setting theoryに基づいたポートセッティングの有用性

    内藤 剛, 大沼 忍, 佐々木 宏之, 三浦 康, 鹿郷 昌之, 森川 孝則, 田中 直樹, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 元井 冬彦, 吉田 寛, 林 洋毅, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　187-187　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1454. 外科診療における漢方の役割 大建中湯胃内投与の結腸運動亢進効果におけるTRPV1の関与

    柴田 近, 菊地 大介, 井本 博文, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 羽根田 祥, 長尾 宗紀, 大沼 忍, 工藤 克昌, 佐々木 宏之, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　342-342　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1455. 保険収載後の腹腔鏡下膵切除術 安全な普及を目指して

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 大沼 忍, 工藤 昌克, 青木 豪, 深瀬 耕二, 乙供 茂, 大塚 英郎, 坂田 直昭, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　427-427　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1456. 大腸癌in vivoマウスモデルによるS-1/LV連日・隔日投与法の評価と病理学的検討

    小村 俊博, 工藤 克昌, 大沼 忍, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 海野 倫明, 白坂 哲彦

    日本外科学会雑誌　114　(臨増2)　602-602　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1457. ヒト大腸癌細胞株マウス同所移植モデルを用いた上皮間葉転換及び転移カスケードの解析

    松田 泰史, 三浦 康, 石田 和之, 藤渕 航, 佐々木 宏之, 大沼 忍, 工藤 克昌, 羽田 祥, 長尾 宗紀, 田中 直樹, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　619-619　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1458. 腸管内分泌細胞におけるIL-23の機能とクローン病との関連性

    鈴木 秀幸, 小川 仁, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 大沼 忍, 工藤 克昌, 羽根田 祥, 柴田 近, Mark Kidd, Oystein Brenna, Bjorn Gustafsson, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　769-769　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1459. 当院における肥満手術後の体重減少効果の検討

    宮地 智洋, 田中 直樹, 内藤 剛, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　779-779　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1460. 2型糖尿病は手術で「治す」

    田中 直樹, 内藤 剛, 柴田 近, 井本 博文, 宮地 智洋, 森川 孝則, 鹿郷 昌之, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 三浦 康, 林 洋毅, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　779-779　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1461. クローン病における吻合法別の再手術率の検討 端々吻合v.s.機能的端々吻合

    羽根田 祥, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 工藤 克昌, 大沼 忍, 佐々木 宏之, 元井 冬彦, 吉田 寛, 片寄 友, 三浦 康, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　789-789　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1462. 潰瘍性大腸炎に対する回腸肛門(管)吻合術終了後の人工肛門再造設症例の検討

    長尾 宗紀, 柴田 近, 羽根田 祥, 小川 仁, 田中 直樹, 工藤 克昌, 佐々木 宏之, 大沼 忍, 森川 孝則, 鹿郷 昌之, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　790-790　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1463. 結腸内寒冷受容体刺激による結腸運動亢進・排便誘発作用の検討

    染谷 崇徳, 柴田 近, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 宮地 智洋, 菊池 大介, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　983-983　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1464. 5-FU投与患者におけるジヒドロピリミジンデヒドロゲナーゼ遺伝子多型と、その表現型との解析

    戸嶋 政秀, 大沼 忍, 工藤 克昌, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　1047-1047　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1465. 直腸カルチノイド手術症例の検討

    大沼 忍, 三浦 康, 内藤 剛, 羽根田 祥, 工藤 克昌, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鹿郷 昌之, 森川 孝則, 鈴木 秀幸, 梶原 大輝, 戸嶋 政秀, 小村 俊博, 松田 泰史, 染谷 崇徳, 吉田 寛, 元井 冬彦, 片寄 友, 柴田 近, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　795-795　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1466. 胃癌手術症例における術後のCONUT法による栄養評価の検討

    工藤 克昌, 柴田 近, 大沼 忍, 羽根田 祥, 梶原 大輝, 小村 俊博, 戸嶋 政秀, 三浦 康, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鈴木 秀幸, 松田 泰史, 染谷 崇徳, 片寄 友, 元井 冬彦, 吉田 寛, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　948-948　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1467. 胆道癌手術に有用な外科解剖と画像診断 MDCTからみた肝門部動門脈解剖 左側からの肝切除で把握すべき分岐形態

    吉田 寛, 青木 修一, 林 洋毅, 中川 圭, 森川 孝則, 岡田 恭穂, 大塚 英郎, 乙供 茂, 水間 正道, 坂田 直昭, 深瀬 耕二, 青木 豪, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　145-145　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1468. Dorsal liverにおける門脈胆管枝の立体解剖 MDCTにもとづく解析

    青木 修一, 水間 正道, 吉田 寛, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 乙供 茂, 坂田 直昭, 深瀬 耕二, 青木 豪, 元井 冬彦, 内藤 剛, 三浦 康, 柴田 近, 片寄 友, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　668-668　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1469. cIAP2を標的とする消化器癌の新規治療戦略の提案

    三浦 康, 唐澤 秀明, 藤渕 航, 石田 和之, 柴田 近, 内藤 剛, 小川 仁, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 工藤 克昌, 鹿郷 昌之, 森川 孝則, 田中 直樹, 片寄 友, 元井 冬彦, 吉田 寛, 江川 新一, 海野 倫明

    日本外科学会雑誌　114　(臨増2)　1048-1048　2013/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1470. 膵体尾部切除術クリニカルパス導入による周術期管理の改善

    岡田恭穂, 元井冬彦, 青木豪, 深瀬耕二, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 中川圭, 森川孝則, 林洋毅, 吉田寛, 内藤剛, 三浦康, 片寄友, 柴田近, 江川新一, 海野倫明

    日本消化器病学会雑誌　110　A338　2013/02/20

    ISSN： 0446-6586

  1471. ドナー膵の機能評価を予見するためのCT所見に関する検討

    坂田直昭, 江川新一, 力山敏樹, 吉松軍平, 元井冬彦, 三浦康, 片寄友, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　40th　81　2013/02

  1472. 膵島移植における安全かつ有効な移植部位の検討

    土屋朗之, 坂田直昭, 吉松軍平, 畠達夫, 深瀬正彦, 青木豪, 三浦康, 柴田近, 片寄友, 江川新一, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　40th　79　2013/02

  1473. 【胆膵癌の早期診断フロントライン】 膵 臨床 膵癌高危険群 疫学からみた膵癌の高危険群と早期診断

    江川 新一, 水間 正道, 濱田 晋, 海野 倫明, 下瀬川 徹

    肝・胆・膵　66　(2)　251-259　2013/02

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1474. 膵管内乳頭粘液性腫瘍(IPMN)の良悪性診断におけるFDG-PET/CTの有用性の検討

    畠 達夫, 坂田 直昭, 青木 豪, 岡田 恭穂, 森川 孝則, 菅野 敦, 林 洋毅, 吉田 寛, 元井 冬彦, 内藤 剛, 正宗 淳, 三浦 康, 片寄 友, 柴田 近, 下瀬川 徹, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A216-A216　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1475. デジタル画像処理によるストーマ周囲皮膚障害発生の予測

    鈴木 秀幸, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 内藤 剛, 高橋 真紀, 伊藤 由美, 柴田 近, 海野 倫明

    日本ストーマ・排泄リハビリテーション学会誌　29　(1)　65-65　2013/02

    Publisher: 日本ストーマ・排泄リハビリテーション学会

    ISSN： 1882-0115

  1476. 家族性大腸腺腫症合併胃癌症例の検討

    柴田 近, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 工藤 克昌, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A221-A221　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1477. 生活習慣病に対する消化管手術の有効性、減量手術の体重減少効果および糖尿病改善効果

    内藤 剛, 田中 直樹, 宮地 智洋, 井本 博文, 森川 孝則, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 大沼 忍, 佐々木 宏之, 鹿郷 昌之, 元井 冬彦, 吉田 寛, 林 洋毅, 岡田 恭穂, 片寄 友, 三浦 康, 柴田 近, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A286-A286　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1478. 潰瘍性大腸炎に対する回腸肛門吻合術後の難治性吻合部合併症の検討

    長尾 宗紀, 柴田 近, 羽根田 祥, 小川 仁, 田中 直樹, 工藤 克昌, 佐々木 宏之, 大沼 忍, 森川 孝則, 鹿郷 昌之, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 友, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A321-A321　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1479. 肥満からみた腹腔鏡補助下幽門側胃切除術の短期成績の検討

    田中 直樹, 鹿郷 昌之, 柴田 近, 工藤 克昌, 内藤 剛, 森川 孝則, 佐々木 宏之, 大沼 忍, 羽根田 祥, 長尾 宗紀, 三浦 康, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本胃癌学会総会記事　85回　393-393　2013/02

    Publisher: (一社)日本胃癌学会

  1480. 胃癌術後1年後のCONUT法による栄養評価の検討

    工藤 克昌, 柴田 近, 田中 直樹, 佐々木 宏之, 鹿郷 昌之, 内藤 剛, 森川 孝則, 大沼 忍, 長尾 宗紀, 羽根田 祥, 三浦 康, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本胃癌学会総会記事　85回　397-397　2013/02

    Publisher: (一社)日本胃癌学会

  1481. 外科医必読膵管内乳頭粘液性腫瘍(IPMN)のすべて 8.分枝型IPMNの診療アルゴリズム

    青木豪, 元井冬彦, 江川新一, 海野倫明

    外科　75　(2)　161-166　2013/02/01

    ISSN： 0016-593X

  1482. クローン病の吻合法(端々吻合v.s.機能的端々吻合)からみた長期成績

    羽根田 祥, 小川 仁, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 工藤 克昌, 大沼 忍, 佐々木 宏之, 神山 篤史, 元井 冬彦, 吉田 寛, 片寄 友, 三浦 康, 柴田 近, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A227-A227　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1483. 炎症性腸疾患に合併したストーマ周囲壊疽性膿皮症(PG)の検討

    工藤 克昌, 柴田 近, 小川 仁, 長尾 宗紀, 羽根田 祥, 大沼 忍, 森川 孝則, 田中 直樹, 佐々木 宏之, 神山 篤史, 三浦 康, 内藤 剛, 鹿郷 昌之, 片寄 友, 元井 冬彦, 吉田 寛, 林 洋毅, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A277-A277　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1484. 直腸GISTの治療戦略

    大沼 忍, 三浦 康, 内藤 剛, 工藤 克昌, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 神山 篤史, 林 洋毅, 森川 孝則, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 小川 仁, 片寄 友, 柴田 近, 海野 倫明

    日本消化器病学会雑誌　110　(臨増総会)　A402-A402　2013/02

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1485. 【イレウスの手術up to date】 偽性腸閉塞症に対する手術

    長尾 宗紀, 柴田 近, 三浦 康, 内藤 剛, 海野 倫明

    手術　67　(2)　181-184　2013/02

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1486. 【肥満症治療】 肥満症治療の将来 Metabolic Surgery:Ileal transpositionとDuodeno-jenunal bypass

    田中 直樹, 内藤 剛, 長尾 宗紀, 生澤 史江, 井本 博文, 宮地 智洋, 土屋 堯裕, 海野 倫明

    ホルモンと臨床　61　(2)　183-188　2013/02

    Publisher: (有)医学の世界社

    ISSN： 0045-7167

  1487. 大腸癌術後化学療法におけるTS-1の有害事象の検討

    佐々木 宏之, 三浦 康, 梶原 大輝, 戸嶋 政秀, 小村 俊博, 内藤 剛, 田中 直樹, 渡辺 和宏, 羽根田 祥, 大沼 忍, 工藤 克昌, 佐瀬 友彦, 松田 泰史, 菊地 大介, 柴田 近, 海野 倫明, 佐々木 巌

    日本大腸肛門病学会雑誌　66　(2)　155-155　2013/02

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1488. 胃癌穿孔例の治療方針 二期的手術の有用性

    畠 達夫, 渡辺 和宏, 長尾 宗紀, 坂田 直昭, 高橋 良延, 柴田 近, 海野 倫明

    日本腹部救急医学会雑誌　33　(2)　383-383　2013/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1489. 門脈枝結紮による代償的肝肥大におけるNrf2の役割

    白崎圭一, 白崎圭一, 白崎圭一, 田口恵子, 本橋ほづみ, 海野倫明, 山本雅之

    日本生化学会大会(Web)　86th　2013

  1490. Annual Report of National Clinical Database in Gastroenterological Surgery 2011-2012

    KONNO HIROYUKI, WAKABAYASHI GO, UDAGAWA HARUSHI, UNNO MICHIAKI, KUNISAKI CHIKARA, GOTO MITSUKAZU, SUGIHARA KEN'ICHI, TAKETOMI AKINOBU, TANGOKU AKIRA, WATANABE TOSHIAKI, MOTOMURA NOBORU, HASHIMOTO HIDEKI, MIYATA HIROAKI, MIYATA HIROAKI, TOMOTAKI AI, MORI MASAKI

    日本消化器外科学会雑誌(Web)　46　(12)　952-963 (J-STAGE)　2013

    DOI： 10.5833/jjgs.2013.sr001 　

    ISSN： 1348-9372

  1491. 切除境界膵癌の定義の再考と術前GS療法の適応

    元井冬彦, 青木豪, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　244　2013

  1492. 大腸癌肝転移に対する集学的治療~同時性肝転移に対する第二相試験の2年追跡から~

    中川圭, 片寄友, 山本久二治, 三浦康, 山内淳一郎, 及川昌也, 島村弘宗, 高橋賢一, 児玉英謙, 元井冬彦, 柴田近, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　51st　ROMBUNNO.P86-8　2013

  1493. 切除企図膵癌の集学的治療における術前GS療法の意義と可能性

    力山敏樹, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　253　2013

  1494. 膵尾側からの逆行性アプローチによる腹腔鏡下脾温存膵体尾部切除術

    森川孝則, 内藤剛, 大塚英郎, 川口桂, 青木豪, 深瀬耕二, 薮内伸一, 乙供茂, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 吉田寛, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　315　2013

  1495. 胆道再建術後肝転移症例に対する肝切除術の適応・合併症の検討

    高橋弥生, 乙供茂, 森川孝則, 川口桂, 青木豪, 藪内伸一, 深瀬耕二, 大塚英郎, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　444　2013

  1496. 胆管癌におけるBorderline resectable症例の定義―術前画像診断からの検討―

    大塚英郎, 吉田寛, 川口桂, 青木豪, 薮内伸一, 深瀬耕二, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　242　2013

  1497. 肝門部胆管癌に対する門脈再建を伴う肝拡大右葉・尾状葉切除術

    吉田寛, 片寄友, 林洋毅, 中川圭, 岡田恭穂, 森川孝則, 大塚英郎, 乙供茂, 水間正道, 坂田直昭, 深瀬耕二, 藪内伸一, 青木豪, 川口桂, 元井冬彦, 内藤剛, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　213　2013

  1498. 当科における肝門部胆管癌治療成績からみた治療戦略の妥当性

    林洋毅, 吉田寛, 元井冬彦, 森川孝則, 岡田恭穂, 中川圭, 水間正道, 大塚英郎, 乙供茂, 坂田直昭, 深瀬耕二, 青木豪, 内藤剛, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　251　2013

  1499. 膵頭十二指腸切除術の術後合併症予測における血清プロカルシトニンの有用性

    畠達夫, 吉田寛, 坂田直昭, 青木豪, 深瀬耕二, 乙供茂, 大塚英郎, 水間正道, 中川圭, 岡田恭穂, 森川孝則, 林洋毅, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　434　2013

  1500. 切除不能膵癌に対する化学療法・放射線療法後の補助的切除の意義

    元井冬彦, 水間正道, 森川孝則, 林洋毅, 吉田寛, 片寄友, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　51st　ROMBUNNO.O129-1　2013

  1501. 当科の胆道癌治療成績および日本肝胆膵外科学会プロジェクト胆04研究

    吉田寛, 片寄友, 元井冬彦, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 水間正道, 坂田直昭, 深瀬耕二, 大沼忍, 内藤剛, 柴田近, 江川新一, 海野倫明

    日本消化器癌発生学会総会プログラム・抄録集　24th　79　2013

  1502. 切除部位別門脈合併切除症例の周術期合併症の検討

    深瀬正彦, 坂田直昭, 青木豪, 深瀬耕二, 乙供茂, 水間正道, 大塚英郎, 中川圭, 林洋毅, 岡田恭穂, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　434　2013

  1503. 膵癌腹腔洗浄細胞診陽性症例の治療指針

    乙供茂, 元井冬彦, 川口桂, 青木豪, 藪内伸一, 深瀬耕二, 大塚英郎, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　366　2013

  1504. KRAS statusとベバシズマブ奏効率の検討~大腸癌肝転移の術前補助化学療法第二相試験~

    青木豪, 中川圭, 片寄友, 山本久二治, 三浦康, 山内淳一郎, 及川昌也, 島村弘宗, 高橋賢一, 児玉英謙, 元井冬彦, 内藤剛, 柴田近, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　51st　ROMBUNNO.P18-1　2013

  1505. 切除可能胆管癌に対する術前化学放射線療法‐II相試験中間解析の結果

    片寄友, 中川圭, 吉田寛, 林洋毅, 森川孝則, 水間正道, 元井冬彦, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　51st　ROMBUNNO.O129-6　2013

  1506. 肝IPNBと膵IPMNの臨床病理学的特徴の類似性と相違点

    水間正道, 岡田恭穂, 森川孝則, 乙供茂, 中川圭, 坂田直昭, 大塚英郎, 深瀬耕二, 藪内伸一, 青木豪, 川口桂, 林洋毅, 吉田寛, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　205　2013

  1507. 膵管空腸粘膜吻合に適した縫合糸ホルダーの開発

    中川圭, 元井冬彦, 青木豪, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　25th　282　2013

  1508. 胃癌手術症例に対する術前栄養評価と術後合併症

    工藤 克昌, 柴田 近, 大沼 忍, 羽根田 祥, 田中 直樹, 長尾 宗紀, 佐々木 宏之, 森川 孝則, 中川 圭, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 海野 倫明

    静脈経腸栄養　28　(1)　370-370　2013/01

    Publisher: (株)ジェフコーポレーション

    ISSN： 1344-4980

  1509. Therapeutic Strategy of P-NET

    青木豪, 大塚英郎, 海野倫明

    日本内分泌・甲状腺外科学会雑誌　30　(4)　271-274 (J-STAGE)　2013

    DOI： 10.11226/jaesjsts.30.4_271 　

    ISSN： 2186-9545

  1510. 【肝胆膵外科手術におけるシミュレーションとナビゲーション】 OsiriXを用いた肝門部胆管癌の術前シミュレーション

    吉田 寛, 片寄 友, 内藤 剛, 元井 冬彦, 海野 倫明

    胆と膵　34　(1)　75-79　2013/01

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1511. Evaluation of the Safety and Efficacy of Postoperative Thromboprophylaxis After Hepatobiliary-Pancreatic Surgery

    Hayashi Hiroki, Unno Michiaki, Morikawa Takanori, Motoi Fuyuhiko, Yoshida Hiroshi, Okada Takaho, Nakagawa Kei, Mizuma Masamichi, Naitoh Takeshi, Katayose Yu

    J Abdom Emerg Med　33　(7)　1157-1164　2013

    Publisher: Japanese Society for Abdominal Emergency Medicine

    DOI： 10.11231/jaem.33.1157 　

    ISSN： 1340-2242

    More details Close

    Although chemical thromboprophylaxis after abdominal surgery is recommended for preventing postoperative venous thromboembolism (VTE), the use of such drugs after major hepatobiliary-pancreatic surgery is typically avoided due to the increased risk of hemorrhage. We analyzed the rates of postoperative bleeding events, VTE and morbidity to evaluate the safety and efficacy of chemical thromboprophylaxis in 466 patients who underwent major hepatobiliary-pancreatic surgery. Four thousand international units per day of enoxiaparin were administered for 90 patients, 2.5 mg/day and 1.5 mg/day of fondaparinux was administered for 125 and 58 patients, respectively. The remaining 193 patients did not receive any chemical prophylaxis. Chemical thromboprophylaxis was associated with a significantly increased rate and risk of overall bleeding events as compared to patients who did not receive chemical thromboprophylaxis. Most of the postoperative hemorrhage was minor and chemical prophylaxis did not increase the risk of major hemorrhage requiring blood transfusion or hemostatic intervention. The rate of VTE was decreased in the patients with chemical prophylaxis. We consider that chemical thromboprophylaxis is beneficial and can be safely used even after major hepatobiliary-pancreatic surgery.

  1512. Intraductal papillary mucinous carcinoma, high-grade gastric typeの1例

    菅野 敦, 中野 絵里子, 滝川 哲也, 三浦 晋, 有賀 啓之, 海野 純, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 正宗 淳, 下瀬川 徹, 乙供 茂, 元井 冬彦, 海野 倫明, 笠島 敦子, 藤島 史善, 古川 徹

    膵臓　28　(3)　495-495　2013

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1513. 膵神経内分泌腫瘍再発症例の検討

    森川 孝則, 元井 冬彦, 青木 豪, 深瀬 耕二, 乙供 茂, 大塚 英郎, 坂田 直昭, 水間 正道, 中川 圭, 岡田 恭穂, 林 洋毅, 吉田 寛, 菅野 敦, 笠島 敦子, 内藤 剛, 片寄 友, 柴田 近, 江川 新一, 下瀬川 徹, 海野 倫明

    膵臓　28　(3)　380-380　2013

  1514. Repeated pancreatectomy for metachronous duodenal and pancreatic metastases of renal cell carcinoma.

    Hata, Tatsuo, Sakata, Naoaki, Aoki, Takeshi, Yoshida, Hiroshi, Kanno, Atsushi, Fujishima, Fumiyoshi, Motoi, Fuyuhiko, Masamune, Atsushi, Shimosegawa, Tooru, Unno, Michiaki

    Case Rep Gastroenterol　7　(3)　442-448　2013

    DOI： 10.1159/000355884 　

  1515. Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy.

    Takikawa, Tetsuya, Kanno, Atsushi, Masamune, Atsushi, Hamada, Shin, Nakano, Eriko, Miura, Shin, Ariga, Hiroyuki, Unno, Jun, Kume, Kiyoshi, Kikuta, Kazuhiro, Hirota, Morihisa, Yoshida, Hiroshi, Katayose, Yu, Unno, Michiaki, Shimosegawa, Tooru

    World J Gastroenterol　19　(31)　5182-5186　2013

    DOI： 10.3748/wjg.v19.i31.5182 　

  1516. Clinical experiences in the treatment of pancreatic arteriovenous malformation by total pancreatectomy with islet autotransplantation. International-journal

    Sakata, Naoaki, Goto, Masafumi, Motoi, Fuyuhiko, Hayashi, Hiroki, Nakagawa, Kei, Mizuma, Masamichi, Yamaya, Hideyuki, Hasegawa, Yutaka, Yamaguchi, Suguru, Sawada, Shojiro, Ottomo, Shigeru, Okada, Takaho, Fukase, Koji, Yoshida, Hiroshi, Ito, Tsuneo, Hirota, Morihisa, Ishigaki, Yasushi, Sekiguchi, Satoshi, Rikiyama, Toshiki, Katayose, Yu, Fujimori, Keisei, Egawa, Shinichi, Shimosegawa, Toru, Katagiri, Hideki, Satomi, Susumu, Unno, Michiaki

    Transplantation　96　(5)　e38-e40　2013

    DOI： 10.1097/TP.0b013e3182a01333 　

  1517. 術前化学療法施行後、肝動脈・門脈合併切除でR0切除しえた局所進行膵癌の1例

    川口 桂, 横山 智, 竹村 真一, 土井 孝志, 黒田 房邦, 元井 冬彦, 海野 倫明

    東北医学雑誌　124　(2)　224-224　2012/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1518. 非典型的画像所見を示した非機能性膵神経内分泌腫瘍の1例

    深瀬 正彦, 水間 正道, 大塚 英郎, 吉田 寛, 元井 冬彦, 内藤 剛, 中川 圭, 片寄 友, 海野 倫明, 菅野 敦, 応田 衛久, 正宗 淳, 下瀬川 徹, 江川 新一

    東北医学雑誌　124　(2)　220-220　2012/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1519. 同時性・異時性に多彩な腫瘍性病変を呈したIPMC・pNET併存、浸潤性膵管癌の1切除例

    片桐 宗利, 吉田 寛, 水間 正道, 森川 孝則, 乙供 茂, 林 洋毅, 元井 冬彦, 内藤 剛, 江川 新一, 海野 倫明, 片寄 友, 菅野 敦, 正宗 淳, 下瀬川 徹

    東北医学雑誌　124　(2)　221-222　2012/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1520. 手術映像の保存 技術的進歩と運用上の課題 効率的で合理的な手術画像の保存と利用を目的とした手術室統合画像管理システムの構築

    内藤 剛, 田中 直樹, 森川 孝則, 大沼 忍, 佐々木 宏之, 鹿郷 昌之, 吉田 寛, 元井 冬彦, 三浦 康, 柴田 近, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　17　(7)　248-248　2012/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1521. 肥満外科手術を日本で成功させるためには何が必要か 肥満外科手術を日本で成功させるためには何が必要か 大学病院の立場から

    田中 直樹, 内藤 剛, 柴田 近, 森川 孝則, 井本 博文, 宮地 智洋, 大沼 忍, 佐々木 宏之, 工藤 克昌, 三浦 康, 鹿郷 昌之, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本内視鏡外科学会雑誌　17　(7)　331-331　2012/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1522. 腹腔鏡補助下直腸切除術42症例の検討

    大沼 忍, 内藤 剛, 鹿郷 昌之, 森川 孝則, 田中 直樹, 佐々木 宏之, 長尾 宗紀, 羽根田 祥, 工藤 克昌, 吉田 寛, 元井 冬彦, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　17　(7)　499-499　2012/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1523. 腹腔鏡補助下に切除した内翻したメッケル憩室による成人腸重積症の1例

    伊関 雅裕, 田中 直樹, 森川 孝則, 大沼 忍, 佐々木 宏之, 吉田 寛, 鹿郷 昌之, 元井 冬彦, 内藤 剛, 三浦 康, 片寄 近, 柴田 近, 海野 倫明

    日本内視鏡外科学会雑誌　17　(7)　665-665　2012/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1524. Infliximab投与後に肛門管/痔瘻癌が発生したクローン病症例の4例

    羽根田 祥, 大沼 忍, 工藤 克昌, 内藤 剛, 鹿郷 昌之, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 柴田 近, 森川 孝則, 海野 倫明

    東北医学雑誌　124　(2)　214-214　2012/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1525. 【大腸肛門病外科-最新のトピックス】 炎症性腸疾患 炎症性腸疾患に対する外科治療と薬物療法の位置づけ

    羽根田 祥, 内藤 剛, 小川 仁, 鹿郷 昌之, 三浦 康, 柴田 近, 海野 倫明, 福島 浩平

    外科　74　(13)　1483-1488　2012/12

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1526. 【消化器神経内分泌腫瘍】 その他の機能性膵神経内分泌腫瘍

    柴田 近, 三浦 康, 内藤 剛, 元井 冬彦, 森川 孝則, 海野 倫明

    臨床消化器内科　28　(1)　69-73　2012/12

    Publisher: (株)日本メディカルセンター

    ISSN： 0911-601X

  1527. メタボリックサージャリーと消化管ホルモン

    柴田 近, 内藤 剛, 森川 孝則, 田中 直樹, 宮地 智洋, 石垣 泰, 片桐 秀樹, 海野 倫明

    肥満研究　18　(3)　176-182　2012/12

    Publisher: (一社)日本肥満学会

    ISSN： 1343-229X

  1528. 【癌分子標的治療up to date】 大腸癌肝転移に対するネオアジュバント療法 ベバシズマブの効果

    片寄 友, 山内 淳一郎, 及川 昌也, 桜井 直樹, 武者 宏昭, 島村 弘宗, 三浦 康, 中川 圭, 元井 冬彦, 江川 新一, 海野 倫明

    癌の臨床　58　(6)　349-353　2012/12

    Publisher: (株)篠原出版新社

    ISSN： 0021-4949

  1529. The Effect of Islet Co-Culture with Bone Marrow Derived Mesenchymal Stem Cells in the Polyvinyl Alcohol Device on the Outcome of Islet Xenotransplantation

    G. Yoshimatsu, N. Sakata, M. Ishida, H. Tsuchiya, M. Goto, S. Sumi, M. Unno

    TRANSPLANTATION　94　(10)　701-701　2012/11

    ISSN： 0041-1337

    eISSN： 1534-6080

  1530. The Lessons Learned from Three Cases of Islet Autotransplantation with a Severe Inflammatory Status Due to a Rupture of a Pancreatic Arteriovenous Malformation

    M. Goto, N. Sakata, H. Yamaya, F. Motoi, A. Inagaki, T. Ito, Y. Hasegawa, Y. Ishigaki, H. Katagiri, M. Hirota, T. Shimosegawa, S. Sekiguchi, K. Fujimori, S. Egawa, M. Unno, S. Satomi

    TRANSPLANTATION　94　(10)　710-710　2012/11

    ISSN： 0041-1337

    eISSN： 1534-6080

  1531. Giant Solid Pseudopapillary Neoplasm of the Pancreas in a Middle-Aged Man: A Case Report

    M. Iseki, M. Mizuma, H. Yoshida, T. Okada, K. Nakagawa, H. Hayashi, T. Morikawa, S. Ottomo, N. Sakata, H. Ohtsuka, K. Fukase, T. Aoki, F. Motoi, T. Naitoh, Y. Katayose, S. Egawa, M. Unno

    PANCREAS　41　(8)　1368-1369　2012/11

    ISSN： 0885-3177

  1532. Surgical Treatment for Chronic Pancreatitis, Discussion of Drainage and Total Pancreatectomy With Islet Autotransplantation

    N. Sakata, G. Yoshimatsu, T. Aoki, M. Ishida, K. Fukase, S. Ottomo, M. Mizuma, T. Okada, K. Nakagawa, H. Hayashi, T. Morikawa, H. Yoshida, F. Motoi, T. Naitoh, Y. Katayose, K. Miura, S. Egawa, M. Unno

    PANCREAS　41　(8)　1400-1400　2012/11

    ISSN： 0885-3177

  1533. A Case of Insulinoma With a Minimal Metastasis in a Focal Hepatic Steatosis

    G. Yoshimatsu, K. Nakagawa, N. Sakata, T. Morikawa, H. Yoshida, F. Motoi, T. Naito, K. Miura, Y. Katayose, S. Egawa, M. Unno

    PANCREAS　41　(8)　1415-1415　2012/11

    ISSN： 0885-3177

  1534. Intraoperative Ultrasound Examination Is Useful for Monitoring Transplanted Islets

    N. Sakata, M. Goto, G. Yoshimatsu, M. Mizuma, F. Motoi, S. Satomi, M. Unno

    TRANSPLANTATION　94　(10)　699-699　2012/11

    ISSN： 0041-1337

    eISSN： 1534-6080

  1535. IPMN初回手術時の残膵・膵断端の所見と残膵局所再発との関連について

    岡田恭穂, 江川新一, 乙供茂, 元井冬彦, 水間正道, 林洋毅, 中川圭, 青木豪, 深瀬耕二, 大塚英郎, 坂田直昭, 吉田寛, 内藤剛, 片寄友, 海野倫明

    日本臨床外科学会雑誌　73　405　2012/10/20

    ISSN： 1345-2843

  1536. 膵空腸吻合法・膵管ステントチューブRCT後の取り組み

    乙供茂, 元井冬彦, 深瀬耕二, 大塚英郎, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　73　528　2012/10/20

    ISSN： 1345-2843

  1537. 術前化学療法の有用性の検証からみた最適レジメンスの探索

    元井冬彦, 青木豪, 深瀬耕二, 水間正道, 大塚英郎, 坂田直昭, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　73　364　2012/10/20

    ISSN： 1345-2843

  1538. アルコール性慢性膵炎による仮性嚢胞と鑑別が困難であった膵腺房細胞癌の1例

    嶋 健太郎, 岡田 恭穂, 水間 正道, 林 洋毅, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 菅野 敦, 廣田 衛久, 正宗 淳, 下瀬川 徹, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　764-764　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1539. 感染制御と栄養管理 胃癌手術症例に対するCONUT法による術前栄養評価と術後合併症の評価

    工藤 克昌, 柴田 近, 大沼 忍, 羽根田 祥, 内藤 剛, 鹿郷 昌之, 田中 直樹, 長尾 宗紀, 佐々木 宏之, 三浦 康, 森川 孝則, 鈴木 秀幸, 海野 倫明

    日本外科感染症学会雑誌　9　(5)　529-529　2012/10

    Publisher: (一社)日本外科感染症学会

    ISSN： 1349-5755

  1540. 保険収載後の腹腔鏡下膵体尾部切除術 安全な普及を目指して

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 大沼 忍, 中川 圭, 林 洋毅, 岡田 恭穂, 吉田 寛, 元井 冬彦, 三浦 康, 柴田 近, 片寄 友, 江川 新一, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　458-458　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1541. 当院におけるクローン病に対する外科治療の成績

    羽根田 祥, 内藤 剛, 鹿郷 昌之, 森川 孝則, 長尾 宗紀, 田中 直樹, 工藤 克昌, 佐々木 宏之, 大沼 忍, 梶原 大輝, 小村 俊博, 戸嶋 政秀, 三浦 康, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　518-518　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1542. 子宮内避妊器具長期留置が原因と思われた腹部放線菌症の一例

    土屋 朗之, 田中 直樹, 佐々木 宏之, 工藤 克昌, 大沼 忍, 羽根田 祥, 坂田 直昭, 森川 孝則, 鹿郷 昌之, 内藤 剛, 三浦 康, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　713-713　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1543. 大腸全摘術後イレウスに対する経ストーマチューブの有効性と問題点

    鈴木 秀幸, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 内藤 剛, 大沼 忍, 羽根田 祥, 工藤 克昌, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　855-855　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1544. 家族性大腸腺腫症に合併する胃癌の臨床病理学的特徴

    柴田 近, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 工藤 克昌, 長尾 宗紀, 羽根田 祥, 大沼 忍, 佐々木 宏之, 森川 孝則, 吉田 寛, 元井 冬彦, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　870-870　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1545. 幽門側胃切除術(Roux-en-Y法)における再建術式の検討

    工藤 克昌, 大沼 忍, 羽根田 祥, 梶原 大輝, 小村 俊博, 三浦 康, 鹿郷 昌之, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鈴木 秀幸, 森川 孝則, 内藤 剛, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　530-530　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1546. 肝硬変に合併した回腸人工肛門周囲静脈瘤出血に対し経皮的塞栓術が有用であった1例

    梶原 大輝, 工藤 克昌, 大沼 忍, 羽根田 祥, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 鹿郷 昌之, 内藤 剛, 三浦 康, 片寄 友, 柴田 近, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　792-792　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1547. 同時性巨大多発肝転移を伴う小腸GISTに対し計7回の肝切除により長期生存を得ている1例

    青木 修一, 林 洋毅, 水間 正道, 岡田 恭穂, 中川 圭, 大塚 英郎, 吉田 寛, 元井 冬彦, 内藤 剛, 三浦 康, 柴田 近, 片寄 友, 海野 倫明

    日本臨床外科学会雑誌　73　(増刊)　953-953　2012/10

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1548. 膵動静脈奇形に対する新たな治療戦略

    坂田直昭, 後藤昌史, 元井冬彦, 林洋毅, 中川圭, 水間正道, 山谷英之, 長谷川豊, 澤田正二郎, 吉松軍平, 伊藤経夫, 菅野敦, 廣田衛久, 石垣泰, 力山敏樹, 江川新一, 片桐秀樹, 下瀬川徹, 里見進, 海野倫明

    日本消化器病学会雑誌　109　A765　2012/09/15

    ISSN： 0446-6586

  1549. 膵島移植における骨髄細胞共移植のnerve growth factor(NGF)の効果について

    吉松軍平, 坂田直昭, 土屋朗之, 青木豪, 元井冬彦, 内藤剛, 片寄友, 三浦康, 江川新一, 海野倫明

    移植　47　232　2012/09

    ISSN： 0578-7947

  1550. 急性炎症を伴う膵全摘疾患を対象とした自家膵島移植における膵島分離・移植法に関する提言

    後藤昌史, 坂田直昭, 山谷英之, 元井冬彦, 関口悟, 藤盛啓成, 江川新一, 海野倫明, 里見進

    移植　47　234　2012/09

    ISSN： 0578-7947

  1551. miR-197は膵癌細胞のEMT誘導因子であり、p120 catenin発現を制御する

    濱田 晋, 佐藤 賢一, 三浦 晋, 廣田 衛久, 菅野 敦, 正宗 淳, 菊田 和宏, 粂 潔, 海野 純, 江川 新一, 元井 冬彦, 海野 倫明, 下瀬川 徹

    日本消化器病学会雑誌　109　(臨増大会)　A741-A741　2012/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

    eISSN： 1349-7693

  1552. 自己免疫性膵炎の合併が疑われた通常型膵癌の1例

    菅野 敦, 滝川 哲也, 三浦 晋, 有賀 啓之, 海野 純, 濱田 晋, 粂 潔, 菊田 和宏, 廣田 衛久, 正宗 淳, 坂田 直昭, 元井 冬彦, 海野 倫明, 石田 和之, 下瀬川 徹

    Gastroenterological Endoscopy　54　(Suppl.2)　2826-2826　2012/09

    Publisher: (一社)日本消化器内視鏡学会

    ISSN： 0387-1207

    eISSN： 1884-5738

  1553. 潰瘍性大腸炎術後早期イレウスの特徴

    鈴木 秀幸, 工藤 克昌, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 三浦 康, 内藤 剛, 大沼 忍, 羽根田 祥, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　65　(9)　619-619　2012/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1554. 70歳以上高齢者大腸癌に対する経口フッ化ピリミジン製剤による補助化学療法

    大沼 忍, 三浦 康, 内藤 剛, 長尾 宗紀, 羽根田 祥, 佐々木 宏之, 工藤 克昌, 鈴木 秀幸, 戸嶋 政秀, 梶原 大輝, 柴田 近, 海野 倫明

    日本大腸肛門病学会雑誌　65　(9)　768-768　2012/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1555. 【消化器癌に対するneo-adjuvant therapyの最新情報】 進行胆管癌に対するneo-adjuvant therapy

    水間 正道, 中川 圭, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 海野 倫明

    外科　74　(9)　962-965　2012/09

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1556. 慢性膵炎の外科的治療に関する検討

    坂田 直昭, 吉松 軍平, 青木 豪, 石田 晶玄, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 三浦 康, 海野 倫明

    移植　47　(総会臨時)　312-312　2012/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

  1557. von Hippel-Lindau病に生じる膵腫瘍と病理診断のpitfall

    佐藤 直実, 笠島 敦子, 石田 和之, 谷内 真司, 前川 尚志, 齊藤 涼子, 柴原 裕紀子, 藤島 史喜, 中村 保宏, 渡辺 みか, 海野 倫明, 笹野 公伸

    日本内分泌学会雑誌　88　(2)　896-896　2012/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

    eISSN： 2186-506X

  1558. 膵希少腫瘍の治療選択 膵漿液性嚢胞腫瘍に対する治療選択

    青木豪, 元井冬彦, 江川新一, 海野倫明

    胆とすい　33　(8)　679-684　2012/08/15

    ISSN： 0388-9408

  1559. デオキシシチジンキナーゼの発現量低下が膵癌細胞における抗癌剤獲得耐性の一因である(Suppression of deoxycytidine kinase (dCK) expression is essential for the acquation chemoresistance in pancreatic cancer)

    川口 桂, 元井 冬彦, 大塚 英郎, 江川 新一, 寺崎 哲也, 海野 倫明

    日本癌学会総会記事　71回　54-54　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1560. ゲムシタビン耐性胆道癌に対するS-1の効果と有害事象の検討

    片寄 友, 大塚 英郎, 北村 洋, 益田 邦洋, 中川 圭, 山本 久仁治, 吉田 寛, 森川 孝則, 元井 冬彦, 力山 敏樹, 林 洋毅, 水間 正道, 海野 倫明

    胆道　26　(3)　486-486　2012/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1561. 化学療法が著効し根治切除を施行し得た高度局所進行胆嚢癌の1例

    伊関 雅裕, 水間 正道, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 大塚 英郎, 深瀬 耕二, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 坂本 康寛, 蒲生 真紀夫, 海野 倫明

    胆道　26　(3)　490-490　2012/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1562. ヒト大腸癌細胞株マウス同所移植を用いた上皮間葉転換及び転移カスケードの解析(EMT and metastatic cascade in orthotopic implantation mouse model with human colorectal cancer cell line)

    松田 泰史, 佐々木 宏之, 三浦 康, 石田 和之, 大沼 忍, 長尾 宗紀, 田中 直樹, 内藤 剛, 片寄 友, 柴田 近, 海野 倫明

    日本癌学会総会記事　71回　214-214　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1563. Stemofolineは多剤耐性ABC transporter p-glycoproteinの抑制剤である(Stemofoline is a potent natural product modulator of the multidrug resistance-linked P-glycoprotein (ABCB1))

    大沼 忍, Chanmahasathien Wisinee, 三浦 康, 佐々木 宏之, 梶原 大輝, 小村 俊博, 戸嶋 政秀, 松田 泰史, 片寄 友, 柴田 近, 海野 倫明, Ambudkar Suresh, Limtrakul Pornngarm

    日本癌学会総会記事　71回　123-123　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1564. 直腸癌を含む骨盤内悪性腫瘍における免疫組織化学的な鑑別診断法の確立と、その微小癌・転移の早期診断への応用(Differentiating rectal carcinoma by immunohistochemistry of other pelvic malignancies and further clinical application)

    三浦 康, 石田 和之, 藤渕 航, 伊藤 明宏, 新倉 仁, 佐々木 宏之, 大沼 忍, 佐瀬 友彦, 梶原 大輝, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本癌学会総会記事　71回　277-277　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1565. ゲムシタビン耐性ヒト癌細胞株におけるdeoxycytidine kinaseの不活化(Deoxycytidine kinase is frequently inactivated in acquired gemcitabine-resistant human cancer cells)

    齋木 由利子, 吉野 優樹, 福重 真一, 砂村 真琴, 石田 晶玄, 元井 冬彦, 江川 新一, 海野 倫明, 堀井 明

    日本癌学会総会記事　71回　237-237　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1566. 【エキスパートの膵切除術】 腹腔鏡下膵体尾部切除術 適応と手術手技

    森川 孝則, 内藤 剛, 元井 冬彦, 江川 新一, 海野 倫明

    手術　66　(9)　1233-1236　2012/08

    Publisher: 金原出版(株)

    ISSN： 0037-4423

  1567. ヒト結腸癌におけるRUNX2の発現意義 ERβを介した予後規定因子(RUNX2 in human colon earcinoma: a potent prognostic factor associated with estrogen receptor)

    佐瀬 友彦, 鈴木 貴, 三浦 康, 椎葉 健一, 佐藤 郁郎, 高木 清司, 小野寺 好明, 三木 康宏, 大沼 忍, 佐々木 宏之, 柴田 近, 海野 倫明, 笹野 公伸

    日本癌学会総会記事　71回　491-491　2012/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1568. P-10 結腸内寒冷受容体刺激による結腸運動亢進・排便誘発作用の検討(ポスターセッション2,一般演題(ポスター),第54回日本平滑筋学会総会)

    染谷 崇徳, 柴田 近, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 松田 泰史, 宮地 智洋, 菊地 大介, 井本 博文, 海野 倫明

    日本平滑筋学会雑誌　16　(1)　"J-45"　2012/07/02

    Publisher: 日本平滑筋学会

    ISSN： 1342-8152

  1569. 被災地医療体験実習に参加した全国からの医学生の学び

    田畑 雅央, 加賀谷 豊, 水間 正道, 門馬 靖武, 松田 綾音, 海野 倫明, 金塚 完, 八重樫 伸生

    医学教育　43　(Suppl.)　112-112　2012/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  1570. 東日本大震災時の巡回診療参加による医学生の学習態度と進路に関する考えへの影響

    田畑 雅央, 加賀谷 豊, 水間 正道, 門馬 靖武, 松田 綾音, 海野 倫明, 八重樫 伸生, 石井 誠一, 亀岡 淳一, 金塚 完

    医学教育　43　(Suppl.)　151-151　2012/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  1571. 結腸内寒冷受容体刺激による結腸運動亢進・排便誘発作用の検討

    染谷 崇徳, 柴田 近, 長尾 宗紀, 田中 直樹, 佐々木 宏之, 松田 泰史, 宮地 智洋, 菊地 大介, 井本 博文, 海野 倫明

    日本平滑筋学会雑誌　16　(1)　J-45　2012/07

    Publisher: 日本平滑筋学会

    ISSN： 1884-507X

  1572. 当科における幽門側胃切除術(Roux-en-Y法)における術式と術後通過障害の検討

    工藤 克昌, 柴田 近, 大沼 忍, 羽根田 祥, 長尾 宗紀, 田中 直樹, 鹿郷 昌之, 内藤 剛, 三浦 康, 海野 倫明

    胃病態機能研究会誌　44　42-42　2012/07

    Publisher: (株)勁草書房コミュニケーション事業部

    ISSN： 1880-3652

  1573. 大腸癌術後化学療法におけるTS-1の有害事象プロファイルの検討

    佐々木 宏之, 三浦 康, 大沼 忍, 佐瀬 友彦, 梶原 大輝, 戸嶋 政秀, 松田 泰史, 柴田 近, 海野 倫明, 佐々木 巌

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1574. 膵頭十二指腸切除術後の在院死症例の検討

    青木 豪, 石田 晶玄, 坂田 直昭, 岡田 恭穂, 吉田 寛, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会総会　67回　2-2　2012/07

    Publisher: (一社)日本消化器外科学会

  1575. 良性疾患に対する在宅中心静脈栄養療法 カテーテル関連敗血症の危険因子

    柴田 近, 羽根田 祥, 渡辺 和宏, 三浦 康, 内藤 剛, 大沼 忍, 佐々木 宏之, 田中 直樹, 工藤 克昌, 海野 倫明

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1576. 直腸癌を含む骨盤内悪性腫瘍の鑑別診断のための免疫組織診断マーカーセットの提案

    三浦 康, 石田 和之, 小川 仁, 内藤 剛, 大沼 忍, 佐々木 宏之, 渡辺 和宏, 羽根田 祥, 柴田 近, 海野 倫明

    日本消化器外科学会総会　67回　2-2　2012/07

    Publisher: (一社)日本消化器外科学会

  1577. 鏡視下肝胆膵外科手術の手術適応 適応拡大に向けて

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 渡辺 和宏, 元井 冬彦, 力山 敏樹, 柴田 近, 江川 新一, 海野 倫明

    日本消化器外科学会総会　67回　2-2　2012/07

    Publisher: (一社)日本消化器外科学会

  1578. 肥満からみた腹腔鏡補助下胃切除術の短期成績の検討

    田中 直樹, 鹿郷 昌之, 柴田 近, 内藤 剛, 森川 孝則, 渡辺 和宏, 三浦 康, 工藤 克昌, 海野 倫明, 佐々木 巖

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1579. 胃癌手術症例に対するCONUT法による術前栄養評価の検討

    工藤 克昌, 柴田 近, 鹿郷 昌之, 田中 直樹, 三浦 康, 内藤 剛, 渡辺 和宏, 羽根田 祥, 大沼 忍, 海野 倫明

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1580. 高齢者の重症潰瘍性大腸炎に対する外科治療の問題点

    渡辺 和宏, 三浦 康, 内藤 剛, 羽根田 祥, 工藤 克昌, 舟山 裕士, 高橋 賢一, 柴田 近, 佐々木 巖, 海野 倫明

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1581. ステージIV大腸癌の細分類および治療戦略 StageIV大腸癌の長期生存例の解析に基づく治療戦略

    大沼 忍, 三浦 康, 内藤 剛, 佐々木 宏之, 羽根田 祥, 渡辺 和宏, 松田 泰史, 柴田 近, 佐々木 巖, 海野 倫明

    日本消化器外科学会総会　67回　2-2　2012/07

    Publisher: (一社)日本消化器外科学会

  1582. 病的肥満症に対する減量手術の糖尿病改善効果と減量効果

    内藤 剛, 田中 直樹, 井本 博文, 森川 孝則, 渡辺 和宏, 鹿郷 昌之, 柴田 近, 佐々木 巖, 海野 倫明

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1583. 炎症性腸疾患に合併したストーマ周囲壊疽性膿皮症の特徴

    鈴木 秀幸, 柴田 近, 三浦 康, 内藤 剛, 羽根田 祥, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 工藤 克昌, 海野 倫明

    日本消化器外科学会総会　67回　1-1　2012/07

    Publisher: (一社)日本消化器外科学会

  1584. CASE OF PERIPELVIC EXTRAVASATION CAUSED BY RECURRENCE OF CECAL CANCER

    KATAYOSE Yu, NAKAGAWA Kei, MIZUMA Masamichi, HAYASHI Hiroki, EGAWA Shinichi, UNNO Michiaki

    日本臨床外科学会雑誌 = The journal of the Japan Surgical Association　73　(6)　1542-1545　2012/06/25

    DOI： 10.3919/jjsa.73.1542 　

    ISSN： 1345-2843

  1585. 局所進行膵頭部癌に対し術前療法と上腸間膜静脈合併切除を施行しR0切除し得た2症例

    嶋 健太郎, 元井 冬彦, 中川 圭, 赤田 昌紀, 岡田 恭穂, 水間 正道, 林 洋毅, 石田 和之, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    胆と膵　33　(6)　545-549　2012/06

    Publisher: 医学図書出版(株)

    ISSN： 0388-9408

  1586. アーカイブFFPE組織からの質量分析基盤プロテオーム解析に基づく膵癌治療抵抗性予測

    小野川徹, 元井冬彦, 高舘達之, 森川孝則, 前田晋平, 白崎圭一, 吉田寛, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　27　(3)　436　2012/05/30

    ISSN： 0913-0071

  1587. 胆道癌術後に膵癌を発症した3例:胆管癌術後2例および十二指腸乳頭部癌術後1例

    片寄友, 元井冬彦, 力山敏樹, 中川圭, 吉田寛, 小野川徹, 岡田恭穂, 森川孝則, 乙供茂, 坂田直昭, 水間正道, 菅野敦, 廣田衛久, 石田和之, 中村隆司, 内藤剛, 江川新一, 下瀬川徹, 海野倫明

    すい臓　27　(3)　540-540　2012/05/30

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

    eISSN： 1881-2805

  1588. 切除企図膵癌に対する術前治療戦略の意義

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　27　(3)　320　2012/05/30

    ISSN： 0913-0071

  1589. 術中ソナゾイドエコーが有用であった多発肝転移を伴う進行P‐NETの1例

    中山瞬, 乙供茂, 吉田寛, 小野川徹, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 大塚英郎, 坂田直昭, 水間正道, 元井冬彦, 内藤剛, 力山敏樹, 菅野敦, 石田和之, 片寄友, 江川新一, 下瀬川徹, 海野倫明

    すい臓　27　(3)　521　2012/05/30

    ISSN： 0913-0071

  1590. 腹腔動脈合併膵体尾部切除(DP‐CAR)施行し長期生存し得たIPMN由来浸潤性膵管癌の一例

    赤田昌紀, 力山敏樹, 元井冬彦, 江川新一, 高橋道長, 後藤慎二, 佐藤俊, 上野達也, 有明恭平, 海野倫明, 内藤広郎

    すい臓　27　(3)　519　2012/05/30

    ISSN： 0913-0071

  1591. A phase II multicenter trial of mFOLFOX6 as adjuvant treatment after resection of liver metastases from colorectal cancer (Miyagi-HBPCOG Trial-001): The final data of progression-free survival

    Yu Katayose, Kuniharu Yamamoto, Shinichi Takemura, Michinaga Takahashi, Ryuji Nakamura, Hiromune Shimamura, Taku Asanuma, Tetsuyuki Uchiyama, Kojin Endo, Masaya Oikawa, Kenichi Shiiba, Kei Nakagawa, Shinichi Egawa, Michiaki Unno

    JOURNAL OF CLINICAL ONCOLOGY　30　(15)　2012/05

    ISSN： 0732-183X

    eISSN： 1527-7755

  1592. 肝胆膵領域の外科治療 これまでの到達点、これからの課題 肝門部胆管癌の切除方法 脈管合併切除とアプローチ 肝門部胆管癌症例に対する血管合併切除の意義と手術治療成績

    吉田 寛, 力山 敏樹, 内藤 剛, 元井 冬彦, 小野川 徹, 岡田 恭穂, 森川 孝則, 中川 圭, 林 洋毅, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 深瀬 耕二, 石田 晶玄, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　197-197　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1593. 症例からみた胆嚢癌術式選択 Stage3以上の進行胆嚢癌に対する手術術式の検討

    林 洋毅, 力山 敏樹, 元井 冬彦, 吉田 寛, 森川 孝則, 岡田 恭穂, 中川 圭, 大塚 英郎, 乙供 茂, 水間 正道, 坂田 直昭, 深瀬 耕二, 石田 晶玄, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　207-207　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1594. 膵嚢胞性腫瘍の治療戦略 IPMNの手術治療方針 特に腫瘍本体の性状・膵断端の所見と残膵局所再発との関連について

    岡田 恭穂, 江川 新一, 乙供 茂, 元井 冬彦, 林 洋毅, 中川 圭, 水間 正道, 石田 晶玄, 深瀬 耕二, 坂田 直昭, 大塚 英郎, 森川 孝則, 小野川 徹, 吉田 寛, 内藤 剛, 力山 敏樹, 片寄 友, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　211-211　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1595. PVEの適応と限界 当科における門脈塞栓術の現状と残肝容積率増大因子の検討

    深瀬 耕二, 石田 晶玄, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 小野川 徹, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　220-220　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1596. 解剖学的変異や特殊な症例の胆管癌に対する手術 肝門部胆管癌における門脈分岐変異時の胆管形態と術式選択

    力山 敏樹, 吉田 寛, 小野川 徹, 林 洋毅, 岡田 恭穂, 森川 孝則, 中川 圭, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 深瀬 耕二, 石田 晶玄, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　230-230　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1597. 膵空腸吻合法 安全確実な膵空腸吻合の工夫 ステント留置の功罪

    石田 晶玄, 元井 冬彦, 深瀬 耕二, 水間 正道, 乙供 茂, 大塚 英郎, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 小野川 徹, 吉田 寛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　233-233　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1598. 残肝ICG消失率による胆道癌術前肝予備能の評価

    大塚 英郎, 深瀬 耕二, 石田 晶玄, 水間 正道, 坂田 直昭, 乙供 茂, 岡田 恭穂, 中川 圭, 森川 孝則, 林 洋毅, 吉田 寛, 小野川 徹, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　270-270　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1599. StageII胆管癌への術前化学放射線療法の意義

    中川 圭, 片寄 友, 伊関 雅裕, 土師 陽一, 嶋 健太郎, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 林 洋毅, 森川 孝則, 小野川 徹, 吉田 寛, 元井 冬彦, 力山 敏樹, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　333-333　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1600. 本学で施行した自家膵島移植の3例

    坂田 直昭, 後藤 昌史, 元井 冬彦, 林 洋毅, 中川 圭, 水間 正道, 吉松 軍平, 石田 晶玄, 深瀬 耕二, 乙供 茂, 大塚 英郎, 森川 孝則, 岡田 恭穂, 吉田 寛, 小野川 徹, 力山 敏樹, 内藤 剛, 片寄 友, 江川 新一, 里見 進, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　353-353　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1601. 胆管内乳頭腫瘍(IPNB)の1例

    土屋 朗之, 坂田 直昭, 石田 晶玄, 深瀬 耕二, 水間 正道, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 小野川 徹, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　432-432　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1602. DP-CAR合併症および術前化学療法との関連性に関する検討

    乙供 茂, 元井 冬彦, 吉田 寛, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 小野川 徹, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　438-438　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1603. インスリノーマ初回切除後19年を経過し治療抵抗性となった症例に対してスニチニブが奏効した1例

    吉松 軍平, 坂田 直昭, 林 洋毅, 石田 晶玄, 深瀬 耕二, 乙供 茂, 大塚 英郎, 水間 正道, 岡田 恭穂, 中川 圭, 森川 孝則, 小野川 徹, 吉田 寛, 元井 冬彦, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　445-445　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1604. 膵尾側切除術における至適切離法の検討 120例のretrospective study

    森川 孝則, 元井 冬彦, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 吉田 寛, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　457-457　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1605. 肝胆膵手術周術期における中心静脈カテーテル由来血流感染の危険因子

    水間 正道, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 大塚 英郎, 乙供 茂, 坂田 直昭, 深瀬 耕二, 石田 晶玄, 吉田 寛, 小野川 徹, 元井 冬彦, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24回　537-537　2012/05

    Publisher: (一社)日本肝胆膵外科学会

  1606. 膵液瘻予測因子とISGPF膵液瘻定義の諸問題

    乙供 茂, 元井 冬彦, 江川 新一, 片寄 友, 力山 敏樹, 内藤 剛, 小野川 徹, 吉田 寛, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 坂田 直昭, 水間 正道, 深瀬 耕二, 石田 晶玄, 海野 倫明

    膵臓　27　(3)　373-373　2012/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1607. 膵癌根治手術術前検査としてのFDG-PET検査の重要性

    岡田 恭穂, 元井 冬彦, 乙供 茂, 水間 正道, 中川 圭, 林 洋毅, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 坂田 直昭, 森川 孝則, 小野川 徹, 吉田 寛, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    膵臓　27　(3)　399-399　2012/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1608. 慢性膵炎の外科的標準治療法としてのFrey手術と膵全摘および自家膵島移植の正当性

    坂田 直昭, 元井 冬彦, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 乙供 茂, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 小野川 徹, 吉田 寛, 力山 敏樹, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    膵臓　27　(3)　424-424　2012/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1609. インスリノーマに併存し、focal nodular growthを来したIPMNの1例

    伊関 雅裕, 坂田 直昭, 元井 冬彦, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 乙供 茂, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 吉田 寛, 小野川 徹, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 菅野 敦, 海野 倫明

    膵臓　27　(3)　509-509　2012/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1610. 腹腔鏡下膵手術の現況 当教室における腹腔鏡下膵手術の現状 適応の再検討

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 渡辺 和宏, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 小野川 徹, 吉田 寛, 元井 冬彦, 力山 敏樹, 片寄 友, 柴田 近, 江川 新一, 海野 倫明

    膵臓　27　(3)　312-312　2012/05

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1611. 【胆嚢癌フロントライン】 胆嚢癌フロントライン

    宮崎 勝, 石原 慎, 伊佐山 浩通, 海野 倫明

    肝・胆・膵　64　(4)　621-635　2012/04

    Publisher: (株)アークメディア

    ISSN： 0389-4991

  1612. 術前パニツムマブ/FOLFOX療法により切除可能となった大腸癌肝転移の1例

    藤川 奈々子, 大塚 英郎, 片寄 友, 石田 和之, 宮下 英士, 海野 倫明

    日本臨床外科学会雑誌　73　(4)　926-930　2012/04

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1613. 糖鎖抗原陰性膵癌の臨床病理学的特徴

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　109　A255　2012/03/15

    ISSN： 0446-6586

  1614. SY-5-KL 肝門部胆管癌の診断と治療法の進歩(SY-5 シンポジウム(5)肝門部胆管癌に対する術式選択と外科切除限界,第112回日本外科学会定期学術集会)

    海野 倫明

    日本外科学会雑誌　113　(2)　133-133　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1615. SP-5-2 東日本大震災発生時の手術室の状況と対応 : 東北外科集談会のアンケート調査から(SP-5 特別企画(5)外科医の「東北地方太平洋沖地震」体験談,第112回日本外科学会定期学術集会)

    福田 幾夫, 鈴木 保之, 橋本 浩, 中路 重之, 海野 倫明, 里見 進, 大内 憲明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1616. 膵がんゲムシタビン療法のPK/PGx

    鈴木裕之, 工藤由起, 相馬真志, 菊地正史, 木皿重樹, 松浦正樹, 久道周彦, 江川新一, 海野倫明, 島田美樹, 眞野成康

    日本薬学会年会要旨集　132nd　(4)　175　2012/03/05

    ISSN： 0918-9823

  1617. PD-10-10 先天性胆道拡張症成人例における術後長期合併症の検討(PD-10 パネルディスカッション(10)小児期発症胆道拡張症におけるキャリーオーバー期の諸問題,第112回日本外科学会定期学術集会)

    大塚 英郎, 片寄 友, 力山 敏樹, 元井 冬彦, 吉田 寛, 小野川 徹, 林 洋毅, 岡田 恭穂, 森川 孝則, 中川 圭, 乙供 茂, 水間 正道, 坂田 直昭, 深瀬 耕二, 石田 昌玄, 内藤 剛, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1618. WS-2-3 切除企図膵癌に対する術前化学療法の有効性評価 : R0切除とマーカー陰性化による「真の」R0率を指標として(WS-2 ワークショップ(2)膵癌外科切除成績の向上を目指した治療戦略)

    元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1619. SF-031-5 膵癌診療情報アーカイブとホルマリン固定パラフィン包埋(FFPE)組織を用いた質量分析基盤プロテオミクスからの治療抵抗性予測(SF-031 サージカルフォーラム(31)膵 基礎-2(病因,危険因子,発癌因子),第112回日本外科学会定期学術集会)

    高舘 達之, 小野川 徹, 元井 冬彦, 前田 晋平, 森川 孝則, 白崎 圭一, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1620. SF-077-1 ホルマリン固定パラフィン包埋(FFPE)組織を用いたプロテオミクスにより同定された10種の胆管癌バイオマーカー(SF-077 サージカルフォーラム(77)胆 基礎,第112回日本外科学会定期学術集会)

    前田 晋平, 小野川 徹, 森川 孝則, 高舘 達之, 吉田 寛, 元井 冬彦, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1621. PS-146-3 胆管癌におけるCD133陽性細胞の特徴(PS-146 肝 基礎・その他,ポスターセッション,第112回日本外科学会定期学術集会)

    北村 洋, 吉田 寛, 乙供 茂, 荒木 孝明, 高野 成尚, 中山 瞬, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(2)　2012/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1622. OPERATING ROOM DURING NATURAL DISASTER : LESSONS FROM THE 2011 TOHOKU EARTHQUAKE

    Fukuda Ikuo, Hashimoto Hiroshi, Suzuki Yasuyuki, Satomi Susumu, Unno Michiaki, Ohuchi Noriaki, Nakaji Shigeyuki

    Journal of Japan Surgical Society　113　(2)　241-251　2012/03/01

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1623. 化学療法の進歩に伴う進行膵胆道癌の手術適応 膵癌切除例における術前補助化学療法

    江川 新一, 元井 冬彦, 石田 晶玄, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 小野川 徹, 吉田 寛, 内藤 剛, 力山 敏樹, 片寄 友, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　189-189　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1624. 十二指腸乳頭部癌および中下部胆管癌の治療戦略におけるpitfall 胆管癌切除成績の検討からみる術前補助療法の有用性

    中川 圭, 片寄 友, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 林 洋毅, 森川 孝則, 岡田 恭穂, 小野川 徹, 吉田 寛, 元井 冬彦, 力山 敏樹, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　248-248　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1625. 膵島移植医療に有用な各種画像モダリティの使用法の確立に向けて

    坂田 直昭, 吉松 軍平, Hathout Eba, 小玉 哲也, 江川 新一, 力山 敏樹, 陳 鋭, 石田 晶玄, 土屋 朗之, 後藤 昌史, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　331-331　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1626. 間葉系幹細胞を加えたPVAカプセル化膵島の基礎研究

    吉松 軍平, 坂田 直昭, 後藤 昌史, 角 昭一郎, 石田 晶玄, 土屋 朗之, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　332-332　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1627. Stage3以上の進行胆道癌における予後規定因子の検討ならびに手術適応の検討

    林 洋毅, 力山 敏樹, 元井 冬彦, 吉田 寛, 小野川 徹, 森川 孝則, 岡田 恭穂, 中川 圭, 大塚 英郎, 坂田 直昭, 乙供 茂, 水間 正道, 深瀬 耕二, 石田 晶玄, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　333-333　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1628. 当科における肝胆膵手術SSI予防対策の取り組み

    水間 正道, 力山 敏樹, 吉田 寛, 大塚 英郎, 中川 圭, 林 洋毅, 岡田 恭穂, 森川 孝則, 乙供 茂, 坂田 直昭, 深瀬 耕二, 石田 晶玄, 小野川 徹, 元井 冬彦, 内藤 剛, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　425-425　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1629. 膵癌における腹腔洗浄細胞診の臨床的意義と術前化学療法との関連性の検討

    乙供 茂, 元井 冬彦, 江川 新一, 片寄 友, 力山 敏樹, 吉田 寛, 小野川 徹, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 大塚 英郎, 坂田 直昭, 水間 正道, 深瀬 耕二, 石田 晶玄, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　787-787　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1630. 膵全摘術後の長期の栄養評価

    石田 晶玄, 坂田 直昭, 深瀬 耕二, 水間 正道, 大塚 英郎, 乙供 茂, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 小野川 徹, 吉田 寛, 元井 冬彦, 力山 俊樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　792-792　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1631. 【必読イレウスの診断から治療まで】 機械的イレウス 単純性イレウス 腸壁以外の病変によるイレウス

    大沼 忍, 三浦 康, 内藤 剛, 鹿郷 昌之, 森川 孝則, 田中 直樹, 羽根田 祥, 渡辺 和宏, 佐々木 宏之, 工藤 克昌, 柴田 近, 海野 倫明, 佐々木 巖

    外科　74　(3)　239-244　2012/03

    Publisher: (株)南江堂

    ISSN： 0016-593X

  1632. Stage IV結腸直腸癌手術例における予後因子の検討

    松田 泰史, 大沼 忍, 三浦 康, 内藤 剛, 小川 仁, 鹿郷 昌之, 森川 孝則, 田中 直樹, 羽根田 祥, 渡辺 和宏, 工藤 克昌, 佐々木 宏之, 佐瀬 友彦, 柴田 近, 海野 倫明, 佐々木 巖

    日本大腸肛門病学会雑誌　65　(3)　182-182　2012/03

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1633. 重症潰瘍性大腸炎の手術成績の比較検討 高齢者群vs.非高齢者群

    渡辺 和宏, 三浦 康, 小川 仁, 内藤 剛, 羽根田 祥, 大沼 忍, 佐々木 宏之, 鹿郷 昌之, 森川 孝則, 田中 直樹, 工藤 克昌, 菊池 大介, 佐瀬 友彦, 井本 博文, 鈴木 秀幸, 舟山 裕士, 高橋 賢一, 柴田 近, 海野 倫明, 佐々木 巖

    日本消化器病学会雑誌　109　(臨増総会)　A247-A247　2012/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1634. 当院での腸管病変を有するクローン病に対する手術成績

    羽根田 祥, 三浦 康, 小川 仁, 内藤 剛, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 鹿郷 昌之, 森川 孝則, 田中 直樹, 工藤 克昌, 佐瀬 友彦, 鈴木 秀幸, 小村 俊博, 松田 康史, 梶原 大輝, 戸嶋 政秀, 柴田 近, 海野 倫明, 佐々木 巖

    日本消化器病学会雑誌　109　(臨増総会)　A249-A249　2012/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1635. 幽門側胃切除術(Roux-en-Y法)における術後吻合部狭窄の検討

    工藤 克昌, 柴田 近, 鹿郷 昌之, 田中 直樹, 内藤 剛, 森川 孝則, 渡辺 和宏, 三浦 康, 羽根田 祥, 大沼 忍, 佐々木 宏之, 菊地 大介, 井本 博文, 佐瀬 友彦, 鈴木 秀幸, 梶原 大輝, 小村 俊博, 染谷 崇徳, 海野 倫明, 佐々木 巖

    日本消化器病学会雑誌　109　(臨増総会)　A281-A281　2012/03

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1636. 当科の腹腔鏡補助下胃切除術の治療成績

    田中 直樹, 鹿郷 昌之, 柴田 近, 木内 誠, 工藤 克昌, 内藤 剛, 森川 孝則, 渡辺 和宏, 三浦 康, 小川 仁, 羽根田 祥, 大沼 忍, 佐々木 宏之, 菊地 大介, 井本 博文, 染谷 崇徳, 宮地 智洋, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　113　(臨増2)　632-632　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1637. 在宅中心静脈療法におけるカテーテル敗血症の危険因子

    柴田 近, 羽根田 祥, 小川 仁, 渡辺 和宏, 三浦 康, 内藤 剛, 鹿郷 昌之, 田中 直樹, 大沼 忍, 工藤 克昌, 佐々木 宏之, 森川 孝則, 菊地 大介, 井本 博文, 染谷 崇徳, 鈴木 秀幸, 佐瀬 友彦, 小村 俊博, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　113　(臨増2)　656-656　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1638. 当科における幽門側胃切除術(Roux-en-Y法)における手術術式の検討

    工藤 克昌, 柴田 近, 鹿郷 昌之, 木内 誠, 内藤 剛, 田中 直樹, 森川 孝則, 三浦 康, 小川 仁, 羽根田 祥, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 菊池 大介, 井本 博文, 鈴木 秀幸, 佐瀬 友彦, 染谷 崇徳, 小村 俊博, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　113　(臨増2)　747-747　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1639. 直腸癌局所再発に対する外科治療の功罪

    大沼 忍, 三浦 康, 内藤 剛, 小川 仁, 羽根田 祥, 渡辺 和宏, 佐々木 宏之, 佐瀬 友彦, 柴田 近, 鹿郷 昌之, 森川 孝則, 田中 直樹, 工藤 克昌, 鈴木 秀幸, 梶原 大輝, 戸嶋 政秀, 松田 泰史, 小村 俊博, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　113　(臨増2)　754-754　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1640. 癌分子標的治療up to date ベバシツマブ+mFOLFOXによる切除可能同時性大腸癌肝転移に対する術前化学療法 多施設共同相試験(第1報)(MiyagiHBPCOG)

    片寄 友, 山内 淳一郎, 及川 昌也, 桜井 直樹, 武者 宏昭, 島村 弘宗, 内山 哲之, 遠藤 公人, 高橋 道長, 三浦 康, 中川 圭, 元井 冬彦, 力山 敏樹, 江川 新一, 海野 倫明

    日本外科学会雑誌　113　(臨増2)　198-198　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1641. 術前化学療法にて病理学的CRを得た大腸癌肝転移(6.5cm)の1例

    白崎 圭一, 片寄 友, 石田 和之, 松村 直樹, 江川 新一, 海野 倫明

    日本臨床外科学会雑誌　73　(3)　643-647　2012/03

    Publisher: 日本臨床外科学会

    ISSN： 1345-2843

  1642. ヒト大腸癌におけるRUNX2:Estrogen receptorを介した有力な予後規定因子

    佐瀬 友彦, 鈴木 貴, 三浦 康, 中村 保宏, 大沼 忍, 佐々木 宏之, 唐澤 秀明, 佐藤 龍一郎, 山村 明寛, 鈴木 秀幸, 梶原 大輝, 戸嶋 政秀, 松田 泰史, 柴田 近, 海野 倫明, 佐々木 巌, 笹野 公伸

    日本外科学会雑誌　113　(臨増2)　286-286　2012/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1643. 骨髄間葉系幹細胞を用いたカプセル化膵島の開発

    吉松軍平, 坂田直昭, 土屋朗之, 石田晶玄, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 内藤剛, 片寄友, 江川新一, 後藤昌史, 角昭一郎, 海野倫明

    日本膵・膵島移植研究会プログラム・抄録集　39th　78　2012/02/23

  1644. 高度炎症を伴う膵動静脈奇形に対する自家膵島移植3例の検証

    後藤昌史, 坂田直昭, 山谷英之, 稲垣明子, 元井冬彦, 伊藤経夫, 長谷川豊, 石垣泰, 片桐秀樹, 廣田衛久, 下瀬川徹, 関口悟, 藤盛啓成, 江川新一, 海野倫明, 里見進

    日本膵・膵島移植研究会プログラム・抄録集　39th　62　2012/02/23

  1645. An Analysis of Protein Expressions of Pancreatic Neuroendocrine Tumors of Japanease Patients According to 2010 WHO Classification

    A. Kasajima, K. Ishida, F. Fujishima, F. Motoi, H. Ootsuka, Y. Nakamura, M. Watanabe, M. Unno, H. Sasano

    MODERN PATHOLOGY　25　146A-146A　2012/02

    ISSN： 0893-3952

  1646. An Analysis of Protein Expressions of Pancreatic Neuroendocrine Tumors of Japanease Patients According to 2010 WHO Classification

    A. Kasajima, K. Ishida, F. Fujishima, F. Motoi, H. Ootsuka, Y. Nakamura, M. Watanabe, M. Unno, H. Sasano

    LABORATORY INVESTIGATION　92　146A-146A　2012/02

    ISSN： 0023-6837

  1647. 腹部手術後の血栓症の予防と治療 肝胆膵外科手術におけるVTE予防薬の安全性、有効性の評価

    林 洋毅, 森川 孝則, 力山 敏樹, 元井 冬彦, 吉田 寛, 小野川 徹, 岡田 恭穂, 中川 圭, 坂田 直昭, 大塚 英郎, 乙供 茂, 水間 正道, 深瀬 耕二, 石田 晶玄, 片寄 友, 江川 新一, 海野 倫明

    日本腹部救急医学会雑誌　32　(2)　359-359　2012/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1648. 胆管癌骨転移からの骨折予防 QOL向上を目指したリスク因子の検討

    片寄 友, 中川 圭, 吉田 寛, 林 洋毅, 森川 孝則, 水間 正道, 大塚 英郎, 岡田 恭穂, 乙供 茂, 深瀬 耕二, 坂田 直昭, 石田 晶玄, 小野川 徹, 元井 冬彦, 内藤 剛, 力山 敏樹, 江川 新一, 海野 倫明

    日本腹部救急医学会雑誌　32　(2)　407-407　2012/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1649. 腸重積症を併発し、緊急手術を施行した潰瘍性大腸炎の1例

    羽根田 祥, 三浦 康, 内藤 剛, 渡辺 和宏, 大沼 忍, 佐々木 宏之, 鹿郷 昌之, 森川 孝則, 田中 直樹, 工藤 克昌, 佐瀬 友彦, 鈴木 秀幸, 小村 俊博, 梶原 大輝, 松田 康史, 柴田 近, 海野 倫明, 佐々木 巖

    日本腹部救急医学会雑誌　32　(2)　488-488　2012/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  1650. 当科における腹腔鏡補助下胃全摘術の治療成績

    田中 直樹, 鹿郷 昌之, 柴田 近, 木内 誠, 工藤 克昌, 内藤 剛, 森川 孝則, 渡辺 和宏, 三浦 康, 小川 仁, 羽根田 祥, 大沼 忍, 佐々木 宏之, 海野 倫明, 佐々木 巖

    日本胃癌学会総会記事　84回　307-307　2012/02

    Publisher: (一社)日本胃癌学会

  1651. 幽門側胃切除術(Roux-en-Y法)における手術術式の検討

    工藤 克昌, 柴田 近, 鹿郷 昌之, 木内 誠, 田中 直樹, 内藤 剛, 森川 孝則, 渡辺 和宏, 三浦 康, 小川 仁, 羽根田 祥, 大沼 忍, 佐々木 宏之, 海野 倫明, 佐々木 巖

    日本胃癌学会総会記事　84回　356-356　2012/02

    Publisher: (一社)日本胃癌学会

  1652. 膵癌外科治療における栄養状態に影響する因子:栄養指標CONUTの推移からみた評価

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    静脈経腸栄養　27　(1)　536　2012/01/25

    ISSN： 1344-4980

  1653. Preface II: Highly advanced surgery in the hepatobiliary and pancreatic field

    Michiaki Unno

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES　19　(1)　2-2　2012/01

    DOI： 10.1007/s00534-011-0479-1 　

    ISSN： 1868-6974

  1654. Splice isoforms as therapeutic targets for colorectal cancer. (Carcinogenesis)

    Miura Koh, Fujibuchi Wataru, Unno Michiaki

    Carcinogenesis　33　(12)　2311-2319　2012

    DOI： 10.1093/carcin/bgs347 　

    ISSN： 0143-3334

  1655. Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy.

    Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M

    Br J Surg　99　(4)　524-531　2012

    DOI： 10.1002/bjs.8654 　

  1656. 膵体尾部切除術

    江川新一, 乙供茂, 岡田恭穂, 石田昌玄, 深瀬耕二, 水間正道, 坂田直昭, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 吉田寛, 小野川徹, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24th　159　2012

  1657. LC/ESI‐MS/MSによる患者血清中のゲムシタビン及び代謝物測定法の構築

    鈴木裕之, 工藤由起, 田村淳, 相馬真志, 内田敬, 菊地正史, 木皿重樹, 松浦正樹, 久道周彦, 高橋哉子, 小笠原喜美代, 江川新一, 海野倫明, 島田美樹, 眞野成康

    日本薬学会東北支部大会講演要旨集　51st　93　2012

  1658. 大腸癌肝転移に対する分子標的治療薬を用いた術前治療の効果と安全性の検討

    片寄友, 山内淳一郎, 及川昌也, 島村弘宗, 山本久仁治, 高橋賢一, 内山哲之, 遠藤公人, 中川圭, 三浦康, 吉田寛, 小野川徹, 元井冬彦, 内藤剛, 力山敏樹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24th　220　2012

  1659. Borderline resectable膵癌に対する治療戦略:腫瘍マーカーの正常化を指標とした術前治療の検証

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　24th　198　2012

  1660. 大腸癌同時性肝転移症例の肝切除に対するNeoadjuvant療法の提案

    中川圭, 片寄友, 及川昌也, 山内淳一郎, 島村弘宗, 山本久仁治, 高橋賢一, 児玉英謙, 高橋道長, 遠藤公人, 元井冬彦, 三浦康, 柴田近, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.OS13-3　2012

  1661. アーカイブFFPE組織からのMS基盤プロテオーム解析に基づく膵癌治療抵抗性因子

    小野川徹, 高舘達之, 元井冬彦, 森川孝則, 水間正道, 中川圭, 林洋毅, 吉田寛, 片寄友, 江川新一, 三浦康, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.OS35-4　2012

  1662. 切除可能膵癌に対する化学療法の新しい展開

    江川新一, 元井冬彦, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.S28-2　2012

  1663. 切除企図膵癌に対する術前化学療法の意義・有用性の検証

    元井冬彦, 吉田寛, 片寄友, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.OS36-4　2012

  1664. 骨盤内悪性腫瘍の鑑別診断マーカーセットの提案,更には微小癌・転移早期診断の応用へ

    三浦康, 石田和之, 藤渕航, 伊藤明宏, 新倉仁, 大沼忍, 工藤克昌, 片寄友, 元井冬彦, 吉田寛, 小野川徹, 中川圭, 林洋毅, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.PD02-04　2012

  1665. 大腸癌肝転移切除後mFOLFOX6補助療法の検討―多施設共同第II相試験Miyagi‐HBPCOG‐001

    片寄友, 山本久仁治, 竹村真一, 高橋道長, 中村隆司, 島村弘宗, 浅沼拓, 内山哲之, 遠藤公人, 及川昌也, 椎葉健一, 中川圭, 元井冬彦, 江川新一, 海野倫明

    日本癌治療学会学術集会(CD-ROM)　50th　ROMBUNNO.PD06-12　2012

  1666. 胃癌・大腸癌におけるフッ化ピリミジン系抗癌剤の効果と有害事象を規定する遺伝子群の解析

    戸嶋政秀, 大沼忍, 三浦康, 佐々木宏之, 内藤剛, 片寄友, 江川新一, 柴田近, 佐々木巌, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　1102(J‐STAGE)　2012

    ISSN： 1348-9372

  1667. 膵・胆管合流異常の治療成績と,胆道癌合併症例の検討

    大塚英郎, 元井冬彦, 吉田寛, 小野川徹, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　244(J‐STAGE)　2012

    ISSN： 1348-9372

  1668. 胆管癌80歳以上における外科治療成績の検討:補助化学療法の可能性

    片寄友, 深瀬耕二, 中川圭, 水間正道, 吉田寛, 小野川徹, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　545(J‐STAGE)　2012

    ISSN： 1348-9372

  1669. 膵管内乳頭粘液性腫瘍の臨床的特徴と今後の課題

    乙供茂, 元井冬彦, 坂田直昭, 岡田恭穂, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　249(J‐STAGE)　2012

    ISSN： 1348-9372

  1670. 効果の検証に基づいた当科における肝胆膵手術創感染予防対策

    水間正道, 力山敏樹, 吉田寛, 中川圭, 大塚英郎, 元井冬彦, 内藤剛, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　846(J‐STAGE)　2012

    ISSN： 1348-9372

  1671. 膵癌に対する術前化学療法の意義:癌遺残度と腫瘍マーカー

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　549(J‐STAGE)　2012

    ISSN： 1348-9372

  1672. 慢性膵炎手術に対するクリニカルパス適用の取り組み

    岡田恭穂, 元井冬彦, 乙供茂, 坂田直昭, 吉田寛, 林洋毅, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　830(J‐STAGE)　2012

    ISSN： 1348-9372

  1673. T2胆嚢癌における術式の検討

    林洋毅, 力山敏樹, 元井冬彦, 吉田寛, 中川圭, 森川孝則, 岡田恭穂, 片寄友, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　512(J‐STAGE)　2012

    ISSN： 1348-9372

  1674. 大腸癌同時性肝転移に対する集学的治療戦略

    中川圭, 中川圭, 中川圭, 片寄友, 片寄友, 片寄友, 及川昌也, 山内淳一郎, 島村弘宗, 山本久仁治, 高橋賢一, 三浦康, 三浦康, 江川新一, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　211(J‐STAGE)　2012

    ISSN： 1348-9372

  1675. 手術治療成績から見た肝内胆管癌の治療戦略

    深瀬耕二, 吉田寛, 北村洋, 小野川徹, 元井冬彦, 力山敏樹, 片寄友, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　514(J‐STAGE)　2012

    ISSN： 1348-9372

  1676. 膵頭十二指腸切除術に対するERASプログラムの応用

    吉田寛, 元井冬彦, 岡田恭穂, 乙供茂, 林洋毅, 小野川徹, 力山敏樹, 片寄友, 片寄友, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　201(J‐STAGE)　2012

    ISSN： 1348-9372

  1677. 胆管癌のborderline症例とは?―長軸断端・大動脈周囲リンパ節陽性切除症例と非切除症例の比較検討―

    力山敏樹, 吉田寛, 林洋毅, 小野川徹, 中川圭, 岡田恭穂, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　248(J‐STAGE)　2012

    ISSN： 1348-9372

  1678. 膵動静脈奇形に対する治療戦略としての膵全摘術および自家膵島移植

    土屋朗之, 後藤昌史, 後藤昌史, 元井冬彦, 林洋毅, 中川圭, 水間正道, 力山敏樹, 江川新一, 里見進, 海野倫明

    日本消化器外科学会雑誌(Web)　45　(Supplement1)　1142(J‐STAGE)　2012

    ISSN： 1348-9372

  1679. 胆道癌新規診断バイオマーカーに関する選択反応モニタリング質量分析アッセイ(SRM MS-based assay)及び免疫組織染色(IHC)との相関性

    福田 哲也, 坂東 泰彦, 海野 倫明, 西村 俊秀, 前田 晋平, 小野川 徹, 高館 達之, 三上 紗弥香, 森川 孝則, 力山 敏樹, 片寄 友, 江川 新一

    日本臨床プロテオーム研究会要旨集　2012　(0)　2012

    Publisher: 日本臨床プロテオーム研究会

  1680. 膵癌診療情報アーカイブFFPE組織を用いた質量分析基盤プロテオーム解析に基づく新規治療抵抗性因子

    小野川 徹, 鈴志野 康正, 前田 晋平, 白崎 圭一, 森川 孝則, 箕輪 貴司, 花方 信孝, 坂東 泰彦, 内藤 剛, 力山 敏樹, 片寄 友, 高館 達之, 江川 新一, 西村 俊秀, 海野 倫明, 福田 哲也, 藤井 清永, 元井 冬彦, 鈴木 貴, 三上 紗弥香, 木原 誠, 竹村 太郎

    日本臨床プロテオーム研究会要旨集　2012　(0)　33　2012

    Publisher: 日本臨床プロテオーム研究会

    DOI： 10.14905/jscp.2012.0_33 　

  1681. 【胆嚢癌フロントライン】 薬物治療 胆嚢癌外科切除後adjuvant chemotherapyの現状

    林 洋毅, 海野 倫明

    肝・胆・膵　64巻　(4号)　607-612　2012

  1682. 【外科医のための癌診療データ】 臓器別最新データ 胆道癌 胆道癌の疫学

    林 洋毅, 海野 倫明

    臨床外科　67巻　(11号)　179-185　2012

    DOI： 10.11477/mf.1407104313 　

  1683. 【非切除胆道癌の治療】 切除不能胆管癌の予後と治療戦略

    林 洋毅, 海野 倫明

    消化器内科　55巻　(3号)　367-371　2012

  1684. 【膵腫瘍:診断と治療の進歩】 トピックス 膵癌 外科治療の進歩 (日本内科学会雑誌)

    江川新一, 元井冬彦, 海野倫明

    日本内科学会雑誌　101　(1)　37-42　2012/01

    DOI： 10.2169/naika.101.37 　

  1685. ヒト神経内分泌腫瘍における性ホルモン受容体の発現状況に関する研究

    尾形 博子, 笠島 敦子, Yazdani Samanah, 海野 倫明, 笹野 公伸

    日本内分泌学会雑誌　88　(2)　898-898　2012

  1686. von Hippel‐Lindau病に生じる膵腫瘍と病理診断のpitfall

    佐藤直実, 笠島敦子, 石田和之, 谷内真司, 前川尚志, 齊藤涼子, 柴原裕紀子, 藤島史喜, 中村保宏, 渡辺みか, 海野倫明, 笹野公伸

    日本内分泌病理学会学術総会プログラム・抄録集　16th　30　2012

  1687. 膵動静脈奇形に起因する急性腹膜炎に対しグラフト保護プロトコールの導入により良好な結果を得た自家膵島移植症例の報告

    後藤昌史, 坂田直昭, 山谷英之, 元井冬彦, 山口賢, 猪村武弘, 稲垣明子, 伊藤経夫, 林洋毅, 石垣泰, 片桐秀樹, 長谷川豊, 澤田正二郎, 廣田衛久, 下瀬川徹, 関口悟, 藤盛啓成, 江川新一, 海野倫明, 里見進

    移植　46　(6)　609　2011/12/10

    ISSN： 0578-7947

  1688. 超音波検査による移植膵島の機能評価

    坂田直昭, 小玉哲也, 陳鋭, 吉松軍平, 後藤昌史, 江川新一, 海野倫明

    移植　46　(6)　622-623　2011/12/10

    ISSN： 0578-7947

  1689. A Case Report of Pancreatectomy Preserving the Middle Portion of the Pancreas for Arteriovenous Malformation of Pancreatic Head and Tail

    荒木孝明, 江川新一, 吉田寛, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 下瀬川徹, 石田和之, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(12)　1573-1580 (J-STAGE)-1580　2011/12/01

    DOI： 10.5833/jjgs.44.1573 　

    ISSN： 1348-9372

  1690. 主膵管型IPMN oncocytic typeの1例

    林 晋太郎, 海野 純, 三浦 晋, 滝川 哲也, 有賀 啓之, 鈴木 範明, 濱田 晋, 粂 潔, 菅野 敦, 廣田 衛久, 正宗 淳, 下瀬川 徹, 元井 冬彦, 江川 新一, 海野 倫明, 石田 和之

    東北医学雑誌　123　(2)　216-216　2011/12

    Publisher: 東北医学会

    ISSN： 0040-8700

  1691. 【肝胆膵系疾患に対する腹腔鏡手術】 若手外科医に教える腹腔鏡下胆嚢摘出術

    森川 孝則, 内藤, 剛, 鹿郷, 昌之, 田中, 直樹, 渡辺, 和宏, 海野 倫明

    外科治療　105　(6)　538-541　2011/12

    Publisher: (株)永井書店

    ISSN： 0433-2644

  1692. 内視鏡外科におけるチーム医療 当教室における内視鏡外科専任チームの役割 経緯と結成後の経過

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 渡辺 和宏, 元井 冬彦, 力山 敏樹, 片寄 友, 柴田 近, 江川 新一, 佐々木 巌, 海野 倫明

    日本内視鏡外科学会雑誌　16　(7)　215-215　2011/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1693. 食道・胃良性疾患に対する内視鏡外科の適応 当科の胃粘膜下腫瘍に対する腹腔鏡手術症例の検討

    田中 直樹, 鹿郷 昌之, 内藤 剛, 柴田 近, 森川 孝則, 渡辺 和宏, 工藤 克昌, 羽根田 祥, 佐々木 宏之, 木内 誠, 安藤 敏典, 海野 倫明, 佐々木 巖

    日本内視鏡外科学会雑誌　16　(7)　225-225　2011/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1694. 安全に腹腔鏡下膵尾側切除術を行うためには何が必要か?

    森川 孝則, 内藤 剛, 鹿郷 昌之, 田中 直樹, 渡辺 和宏, 元井 冬彦, 力山 敏樹, 片寄 友, 柴田 近, 江川 新一, 佐々木 巌, 海野 倫明

    日本内視鏡外科学会雑誌　16　(7)　587-587　2011/12

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1695. 膵頭部・尾部動静脈奇形に対し膵中央部温存手術により耐糖能を温存しえた1例

    荒木 孝明, 江川 新一, 吉田 寛, 元井 冬彦, 内藤 剛, 力山 敏樹, 片寄 友, 下瀬川 徹, 石田 和之, 海野 倫明

    日本消化器外科学会雑誌　44　(12)　1573-1580　2011/12

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

    eISSN： 1348-9372

  1696. A Case of the Pancreatic Duct Stenosis at the Body with Focal Atrophic and Fatty Change of the Adjacent Parenchyma

    G. Yoshimatsu, N. Sakata, M. Mizuma, K. Ishida, S. Ottomo, K. Nakagawa, H. Hayashi, F. Motoi, T. Rikiyama, Y. Katayose, S. Egawa, A. Kanno, J. Masamune, T. Shimosegawa, M. Unno

    PANCREAS　40　(8)　1365-1365　2011/11

    ISSN： 0885-3177

  1697. Proteomic Forecast of Postoperative Prognosis of Pancreatic Cancer using Formalin-Fixed Paraffin-Embedded Tissue

    T. Takadate, T. Onogawa, F. Motoi, T. Morikawa, S. Maeda, K. Nakagawa, T. Rikiyama, Y. Katayose, S. Egawa, M. Unno

    PANCREAS　40　(8)　1356-1357　2011/11

    ISSN： 0885-3177

  1698. 90Y DOTATOC and Multidisciplinary Therapies for a Patient with Pancreatic Neuroendocrine Carcinoma with Systemic Metastases

    G. Yoshimatsu, S. Egawa, N. Sakata, F. Motoi, T. Rikiyama, Y. Katayose, M. Unno

    PANCREAS　40　(8)　1365-1365　2011/11

    ISSN： 0885-3177

  1699. 肝胆膵手術周術期における中心静脈カテーテル感染症・血栓症の検討

    水間正道, 林洋毅, 中川圭, 岡田恭穂, 森川孝則, 大塚英郎, 乙供茂, 坂田直昭, 吉田寛, 小野川徹, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本外科感染症学会雑誌　8　(5)　548　2011/11/01

    ISSN： 1349-5755

  1700. 術前治療と後腹膜・神経叢一括郭清による切除境界膵癌に対する治療戦略:R0切除率と切除後マーカー正常化を指標として

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　326　2011/10/20

    ISSN： 1345-2843

  1701. 大腸癌肝転移切除と補助化学療法

    中川圭, 片寄友, 及川昌也, 島村弘宗, 黒田房邦, 高橋道長, 山内淳一郎, 桜井直樹, 山本久仁治, 中村隆司, 内山哲之, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　498　2011/10/20

    ISSN： 1345-2843

  1702. OsiriXを用いた肝門部胆管癌の術前シミュレーション

    吉田寛, 力山敏樹, 元井冬彦, 小野川徹, 岡田恭穂, 森川孝則, 中川圭, 林洋毅, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　327　2011/10/20

    ISSN： 1345-2843

  1703. 膵胆管合流異常,先天性胆道拡張症の手術術式とその合併症の検討

    大塚英郎, 力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 岡田恭穂, 森川孝則, 中川圭, 林洋毅, 乙供茂, 水間正道, 深瀬耕二, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　624　2011/10/20

    ISSN： 1345-2843

  1704. 3種類の膵疾患手術に対するクリニカルパス適用への取り組み―膵疾患手術の標準化を目指して―

    岡田恭穂, 元井冬彦, 乙供茂, 坂田直昭, 深瀬耕二, 大塚英郎, 水間正道, 中川圭, 林洋毅, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　391　2011/10/20

    ISSN： 1345-2843

  1705. 膵転移を認めた胸腺神経内分泌腫瘍(NET)の1例

    堂地大輔, 大塚英郎, 乙供茂, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　72　845　2011/10/20

    ISSN： 1345-2843

  1706. 移植膵島生着に対する超音波検査の有効性

    坂田直昭, 小玉哲也, 陳鋭, 吉松軍平, 後藤昌史, 江川新一, 海野倫明

    移植　46　207　2011/10

    ISSN： 0578-7947

  1707. グラフト保護プロトコールの導入により良好な結果を得た急性腹膜炎下における自家膵島移植症例の報告

    後藤昌史, 坂田直昭, 山谷英之, 元井冬彦, 稲垣明子, 伊藤経夫, 石垣泰, 片桐秀樹, 長谷川豊, 廣田衛久, 下瀬川徹, 関口悟, 藤盛啓成, 江川新一, 海野倫明, 里見進

    移植　46　204　2011/10

    ISSN： 0578-7947

  1708. 【緊急手術の適応と手術手技の実際】 急性感染性膵壊死 (消化器外科)

    江川新一, 林洋毅, 吉田寛, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 海野倫明

    消化器外科　34　(11)　1605-1611　2011/10

  1709. 膵癌に対する術前術後補助療法の現状と今後の展望 (日本消化器病学会雑誌)

    海野倫明, 上野秀樹, 本田五郎, 里井壯平, 庄雅之, 谷眞至, 元井冬彦

    日本消化器病学会雑誌　108　(10)　1676-1695　2011/10

  1710. 【膵癌に対する術前術後補助療法】 膵癌に対する術前化学療法 (日本消化器病学会雑誌)

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　108　(10)　1654-1660　2011/10

  1711. 【癌個別化医療はどこまですすんだのか】 各論 膵癌の個別化医療 分子生物学的解析を中心に (外科)

    元井冬彦, 川口桂, 大峰健, 大槻純男, 大塚英郎, 力山敏樹, 片寄友, 江川新一, 寺崎哲也, 海野倫明

    外科　73　(10)　1073-1078　2011/10

  1712. 膵癌切除3年後に発生し膵癌肝転移と鑑別が困難であった肝内胆管癌の1例

    小松 弘武, 坂田 直昭, 元井 冬彦, 内藤 剛, 片寄 友, 力山 敏樹, 江川 新一, 笠島 敦子, 石田 和之, 海野 倫明

    膵臓　26　(5)　589-597　2011/10

    Publisher: 日本膵臓学会

    ISSN： 0913-0071

  1713. A CASE OF GIANT RETROPERITONEAL LIPOSARCOMA

    YOSHIMATSU Gumpei, SHINYA Fumiaki, ABE Michio, KAWAGUCHI Shinya, SHINODA Masao, UNNO Michiaki

    72　(9)　2431-2436　2011/09/25

    ISSN： 1345-2843

  1714. 膵癌切除後,マーカー正常化生存期間(Marker Free Survival)の意義

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　46　(2)　552　2011/09/13

    ISSN： 0021-4671

  1715. 胆管癌術前化学放射線療法の可能性

    中川圭, 片寄友, 深瀬耕二, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 林洋毅, 森川孝則, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    日本癌治療学会誌　46　(2)　404　2011/09/13

    ISSN： 0021-4671

  1716. 胆管切除を伴う肝右葉切除 (特集 肝胆膵高難度手術のすべて) -- (胆道手術)

    力山 敏樹, 海野 倫明

    手術　65　(10)　1441-1447　2011/09

    Publisher: 金原出版

    ISSN： 0037-4423

  1717. 結腸運動制御における結腸内容物、壁在神経の役割

    菊地 大介, 柴田 近, 鹿郷 昌之, 田中 直樹, 工藤 克昌, 井本 博文, 内藤 剛, 染谷 崇徳, 三浦 康, 小川 仁, 羽根田 祥, 渡辺 和弘, 大沼 忍, 海野 倫明, 佐々木 巖

    日本消化器病学会雑誌　108　(臨増大会)　A845-A845　2011/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1718. 手術治療を行った直腸癌局所再発例の検討

    大沼 忍, 三浦 康, 内藤 剛, 小川 仁, 鹿郷 昌之, 森川 孝則, 田中 直樹, 羽根田 祥, 渡辺 和宏, 工藤 克昌, 佐々木 宏之, 菊地 大介, 佐瀬 友彦, 井本 博文, 鈴木 秀幸, 柴田 近, 海野 倫明, 佐々木 巖

    日本大腸肛門病学会雑誌　64　(9)　717-717　2011/09

    Publisher: (一社)日本大腸肛門病学会

    ISSN： 0047-1801

  1719. Bitter Melon(Mormodica Charantia)の葉から抽出されたKuguacin JはP-glycoproteinの新規抑制剤である

    大沼 忍, 三浦 康, 内藤 剛, 小川 仁, 鹿郷 昌之, 森川 孝則, 田中 直樹, 羽根田 祥, 渡辺 和宏, 工藤 克昌, 佐々木 宏之, 柴田 近, 海野 倫明, 佐々木 巖, Ambudkar S.V, Limtrakul P

    日本消化器病学会雑誌　108　(臨増大会)　A873-A873　2011/09

    Publisher: (一財)日本消化器病学会

    ISSN： 0446-6586

  1720. Bitter melon抽出物Kuguacin Jは薬剤トランスポーターP-glycoproteinの抑制剤である

    大沼 忍, 三浦 康, 内藤 剛, 小川 仁, 鹿郷 昌之, 森川 孝則, 田中 直樹, 羽根田 祥, 渡辺 和宏, 柴田 近, 海野 倫明, 佐々木 巖, Ambudkar Suresh, Pitchakarn Pornsiri, Limtrakul Pornngarm

    日本癌治療学会誌　46　(2)　740-740　2011/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1721. 大腸 大腸癌肝転移に対するmFOLFOX6+ベバシズマブによる病理的効果

    片寄 友, 山内 淳一郎, 及川 昌也, 桜井 直樹, 武者 宏昭, 島村 弘宗, 内山 哲之, 高橋 道長, 遠藤 公人, 三浦 康, 中川 圭, 江川 新一, 海野 倫明, 宮城肝胆膵癌化学療法研究会, Miyagi HBPCOG

    日本癌治療学会誌　46　(2)　439-439　2011/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1722. 神経内分泌腫瘍の病理診断 最近の進歩 膵神経内分泌腫瘍の新WHO分類と病理組織学諸的因子の解析

    笠島 敦子, 石田 和之, 藤島 史喜, 中村 保宏, 渡辺 みか, 元井 冬彦, 大塚 英郎, 海野 倫明, 笹野 公伸

    日本内分泌学会雑誌　87　(2)　817-817　2011/09

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  1723. 胆管癌症例に対する大動脈周囲リンパ節郭清の意義

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 森川孝則, 中川圭, 林洋毅, 大塚英郎, 水間正道, 深瀬耕二, 江川新一, 海野倫明

    胆道　25　(3)　464　2011/08/31

    ISSN： 0914-0077

  1724. 胆管癌骨転移例の臨床学的検討

    片寄友, 中川圭, 力山敏樹, 吉田寛, 小野川徹, 林洋毅, 元井冬彦, 内藤剛, 江川新一, 海野倫明

    胆道　25　(3)　453　2011/08/31

    ISSN： 0914-0077

  1725. An analysis of clinicopathological factors in Japanese pancreatic neuroendocrine tumor patients according to 2010 WHO classification

    A. Kasajima, K. Ishida, F. Fujishima, F. Motoi, H. Ootsuka, Y. Nakamura, M. Watanabe, M. Unno, H. Sasano

    VIRCHOWS ARCHIV　459　S24-S24　2011/08

    ISSN： 0945-6317

  1726. 【外来診療に有用な腫瘍マーカーの知識】 腫瘍マーカーの種類と特徴 DU-PAN-2 (臨牀と研究)

    岡田恭穂, 元井冬彦, 海野倫明

    臨牀と研究　88　(8)　957-959　2011/08

    Publisher: 大道学館出版部

    ISSN： 0021-4965

  1727. 【神経内分泌腫瘍(NET)のすべて】 治療 神経内分泌腫瘍(NET)に対する分子標的治療 (外科)

    大塚英郎, 元井冬彦, 片寄友, 力山敏樹, 内藤剛, 柴田近, 江川新一, 海野倫明

    外科　73　(8)　858-863　2011/08

  1728. 【膵臓症候群(第2版)-その他の膵臓疾患を含めて-】 膵腫瘍 膵癌 小膵癌 (日本臨床)

    江川新一, 元井冬彦, 海野倫明

    日本臨床　別冊　(膵臓症候群)　281-284　2011/07

  1729. 【胆道・膵疾患の画像診断】 胆道疾患 胆管腫瘍 胆管狭窄の画像的良悪性鑑別診断とその限界 (消化器外科)

    水間正道, 力山敏樹, 片寄友, 元井冬彦, 内藤剛, 江川新一, 海野倫明

    消化器外科　34　(8)　1185-1191　2011/07

  1730. 内科および外科の集学的治療が有効であった多発仮性嚢胞を伴う慢性膵炎の1例

    乙供茂, 元井冬彦, 吉田寛, 力山敏樹, 片寄友, 江川新一, 廣田衛久, 下瀬川徹, 海野倫明

    すい臓　26　(3)　467　2011/06/25

    ISSN： 0913-0071

  1731. 本邦2例目の自家膵島移植を行った急性膵炎合併膵動静脈奇形の1例

    坂田直昭, 後藤昌史, 元井冬彦, 山口賢, 伊藤経夫, 林洋毅, 山谷英之, 岡田恭穂, 水間正道, 長谷川豊, 澤田正二郎, 石垣泰, 廣田衛久, 関口悟, 藤盛啓成, 江川新一, 片桐秀樹, 下瀬川徹, 里見進, 海野倫明

    すい臓　26　(3)　389　2011/06/25

    ISSN： 0913-0071

  1732. 膵管減圧術後膵頭部で再燃し,Frey手術を付加して優れた除痛効果をもたらした3症例

    岡田恭穂, 江川新一, 元井冬彦, 坂田直昭, 乙供茂, 深瀬耕二, 水間正道, 大塚英郎, 林洋毅, 森川孝則, 中川圭, 吉田寛, 小野川徹, 力山敏樹, 片寄友, 海野倫明

    すい臓　26　(3)　454　2011/06/25

    ISSN： 0913-0071

  1733. 膵癌術前治療の有効性評価:(Gemcitabine療法とGemcitabine+S1(GS療法)の比較から

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　26　(3)　358　2011/06/25

    ISSN： 0913-0071

  1734. 膵神経内分泌腫瘍に対する腹腔鏡下腫瘍核出術施行例の検討

    森川孝則, 内藤剛, 深瀬耕二, 乙供茂, 大塚英郎, 坂田直昭, 岡田恭穂, 中川圭, 林洋毅, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　26　(3)　393　2011/06/25

    ISSN： 0913-0071

  1735. 膵癌のGemcitabine耐性機構の解明

    齋木由利子, 江川新一, 海野倫明, 砂村眞琴, 堀井明

    すい臓　26　(3)　371　2011/06/25

    ISSN： 0913-0071

  1736. ガストリノーマにおけるグルカゴン負荷試験の意義

    柴田近, 三浦康, 内藤剛, 小川仁, 元井冬彦, 江川新一, 海野倫明, 佐々木巖

    日本内分泌外科学会総会プログラム・抄録集　23rd　80　2011/06

  1737. ガストリノーマに対する外科治療の現状と問題点

    柴田近, 三浦康, 内藤剛, 小川仁, 元井冬彦, 江川新一, 海野倫明, 佐々木巖

    日本内分泌外科学会総会プログラム・抄録集　23rd　66　2011/06

  1738. 膵頭十二指腸切除後ISGPF grade B、Cの膵液瘻防止対策 日本肝胆膵外科学会プロジェクト研究【膵02研究】 膵頭十二指腸切除後膵液瘻重症化因子の検索

    川井 学, 近藤 哲, 山上 裕機, 和田 慶太, 佐野 圭二, 元井 冬彦, 海野 倫明, 里井 壮平, 權 雅憲, 羽鳥 隆, 山本 雅一, 松本 讓, 村上 義昭, 土井 隆一郎, 伊東 昌広, 宮川 秀一, 新地 洋之, 中川原 寿俊, 太田 哲生, 高田 忠敬

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23回　148-148　2011/06

    Publisher: (一社)日本肝胆膵外科学会

  1739. 【見直される胆道がん診療の新展開】 Neoadjuvant chemoradiationtherapyによる胆管癌治療の試み (肝・胆・膵)

    中川圭, 片寄友, 元井冬彦, 力山敏樹, 海野倫明

    肝・胆・膵　62　(6)　1113-1119　2011/06

  1740. SF-014-2 FFPE組織を用いたlabe-free methodによる胆道癌新規バイオマーカーの探索と検証(SF-014 サージカルフォーラム(14)胆管:基礎,第111回日本外科学会定期学術集会)

    前田 晋平, 海野 倫明

    日本外科学会雑誌　112　(1)　353-353　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1741. PS-020-7 結腸運動制御における結腸内容物の役割(PS-020 ポスターセッション(20)大腸:良性-5,第111回日本外科学会定期学術集会)

    菊地 大介, 柴田 近, 鹿郷 昌之, 木内 誠, 田中 直樹, 佐藤 学, 生澤 史江, 井本 博文, 染谷 崇徳, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　112　(1)　541-541　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1742. 膵線房細胞癌切除例の予後と治療方針

    赤田昌紀, 江川新一, 上野達也, 佐藤俊, 後藤慎一, 高橋道長, 内藤広郎, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    日本外科学会雑誌　112　550　2011/05/25

    ISSN： 0301-4894

  1743. 造影MRIによる移植膵島の生着評価法

    坂田直昭, HATHOUT Eba, OBENAUS Andre, 後藤昌史, 江川新一, 海野倫明

    日本外科学会雑誌　112　349　2011/05/25

    ISSN： 0301-4894

  1744. CTによる膵内分泌機能評価の是非

    吉松軍平, 坂田直昭, 江川新一, 力山敏樹, 元井冬彦, 片寄友, 海野倫明

    日本外科学会雑誌　112　398　2011/05/25

    ISSN： 0301-4894

  1745. SY-2-10 IPMN残膵再発に対する膵全摘術の適応とタイミング(SY-2 シンポジウム(2)IPMNをめぐる諸問題-診断から治療まで-,第111回日本外科学会定期学術集会)

    江川 新一, 乙供 茂, 深瀬 耕二, 大塚 英郎, 森川 孝則, 水間 正道, 坂田 直昭, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 小野川 徹, 元井 冬彦, 内藤 剛, 力山 敏樹, 片寄 友, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1746. PD-5-8 切除症例からみた胆管癌の予後規定因子と治療戦略(PD5 パネルディスカッション(5)進行胆道癌に対する切除適応のコンセンサス,第111回日本外科学会定期学術集会)

    吉田 寛, 力山 敏樹, 内藤 剛, 元井 冬彦, 小野川 徹, 岡田 恭穂, 森川 孝則, 中川 圭, 林 洋毅, 大塚 英郎, 乙供 茂, 坂田 直昭, 水間 正道, 深瀬 耕二, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1747. WS-2-4 IT技術を駆使した内視鏡手術室の構築(WS2 ワークショップ(2)手術を支える未来の手術室,第111回日本外科学会定期学術集会)

    内藤 剛, 鹿郷 昌之, 木内 誠, 安藤 敏典, 森川 考則, 力山 俊樹, 江川 新一, 柴田 近, 土屋 誉, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1748. SF-011-1 造影MRIによる移植膵島の生着評価法(SF-011 サージカルフォーラム(11)膵臓:基礎-4,第111回日本外科学会定期学術集会)

    坂田 直昭, Hathout Eba, Obenaus Andre, 後藤 昌史, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1749. SF-020-1 肝胆膵手術創閉鎖における真皮埋没縫合導入によるQOL改善の試み(SF-020 サージカルフォーラム(20)肝臓:周術期管理,第111回日本外科学会定期学術集会)

    水間 正道, 力山 敏樹, 吉田 寛, 小野川 徹, 林 洋毅, 中川 圭, 岡田 恭穂, 森川 孝則, 大塚 英郎, 乙供 茂, 坂田 直昭, 深瀬 耕二, 元井 冬彦, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1750. SF-051-1 CTによる膵内分泌機能評価の是非(SF-051 サージカルフォーラム(51)膵臓:診断,第111回日本外科学会定期学術集会)

    吉松 軍平, 坂田 直昭, 江川 新一, 力山 敏樹, 元井 冬彦, 片寄 友, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1751. SF-072-1 大腸癌肝転移に対する術前および術後化学療法の多施設共同第II相試験からの治療方針検討 : Miyagi HBPCOG-001,004(SF-072 サージカルフォーラム(72)大腸:手術-1,第111回日本外科学会定期学術集会)

    片寄 友, 中川 圭, 山本 久仁治, 及川 昌也, 山内 淳一郎, 内山 哲之, 竹村 真一, 島村 弘宗, 高橋 道長, 三浦 康, 元井 冬彦, 力山 敏樹, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1752. VF-004-4 究極の膵機能温存低侵襲手術 : 膵腫瘍に対する腹腔鏡下核出術(VF-004 ビデオフォーラム(1)膵臓-1,第111回日本外科学会定期学術集会)

    森川 孝則, 内藤 剛, 鹿郷 昌之, 木内 誠, 安藤 敏典, 水間 正道, 大塚 英郎, 乙供 茂, 坂田 直昭, 林 洋毅, 岡田 恭穂, 中川 圭, 吉田 寛, 小野川 徹, 元井 冬彦, 力山 敏樹, 片寄 友, 柴田 近, 江川 新一, 佐々木 巖, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1753. VF-008-1 膵頭十二指腸切除後の膵瘻発生低下を目指した膵管粘膜吻合 : 無作為比較試験の結果を基に(VF-008 ビデオフォーラム(8)膵臓-2,第111回日本外科学会定期学術集会)

    元井 冬彦, 深瀬 耕二, 水間 正道, 乙供 茂, 大塚 英郎, 坂田 直昭, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 吉田 寛, 小野川 徹, 内藤 剛, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1754. PS-026-1 膵線房細胞癌切除例の予後と治療方針(PS-026 ポスターセッション(26)膵臓:集学的治療-1,第111回日本外科学会定期学術集会)

    赤田 昌紀, 江川 新一, 上野 達也, 佐藤 俊, 後藤 慎一, 高橋 道長, 内藤 広郎, 元井 冬彦, 力山 敏樹, 片寄 友, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1755. PS-029-1 局所進行膵体部癌に対する腹腔動脈合併膵体尾部切除の検討(PS-029 ポスターセッション(29)膵臓:その他-2,第111回日本外科学会定期学術集会)

    深瀬 耕二, 有明 恭平, 乙供 茂, 大塚 英郎, 坂田 直昭, 水間 正道, 岡田 恭穂, 中川 圭, 林 洋毅, 森川 孝則, 小野川 徹, 吉田 寛, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1756. PS-105-6 ホルマリン固定パラフィン包埋組織を用いた膵癌新規予後予測マーカーの探索と検証(PS-105 ポスターセッション(105)膵臓:基礎-2,第111回日本外科学会定期学術集会)

    高舘 達之, 元井 冬彦, 藤井 清永, 前田 晋平, 森川 孝則, 竹村 太郎, 箕輪 貴司, 三上 紗弥香, 山田 誠子, 福田 哲也, 板東 泰彦, 碓井 史彦, 力山 敏樹, 片寄 友, 江川 新一, 花方 信孝, 西村 俊秀, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1757. PS-209-2 膵癌術前(進行度)診断ツールとしてのFDG-PET検査の有用性(PS-209 ポスターセッション(209)膵臓:悪性・診断-1,第111回日本外科学会定期学術集会)

    岡田 恭穂, 元井 冬彦, 乙供 茂, 坂田 直昭, 深瀬 耕二, 水間 正道, 大塚 英郎, 中川 圭, 林 洋毅, 吉田 寛, 小野川 徹, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1758. PS-212-5 浸潤性膵管癌におけるEpidermal growth facter receptor (EGFR)発現と臨床病理学的因子の検討(PS-212 ポスターセッション(212)膵臓:悪性・診断-4,第111回日本外科学会定期学術集会)

    三浦 孝之, 元井 冬彦, 石田 和之, 堂地 大輔, 藤川 奈々子, 有明 恭平, 深瀬 耕二, 大塚 英郎, 力山 敏樹, 片寄 友, 江川 新一, 菅野 敦, 佐藤 賢一, 下瀬川 徹, 海野 倫明

    日本外科学会雑誌　112　(1)　2011/05/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1759. Developments for a growing Japanese patient population: Facilitating new technologies for future health care

    Harubumi Kato, Toshihide Nishimura, Norihiko Ikeda, Tesshi Yamada, Tadashi Kondo, Nagahiro Saijo, Kazuto Nishio, Junichiro Fujimoto, Masaharu Nomura, Yoshiya Oda, Bertil Lindmark, Jiro Maniwa, Hitoshi Hibino, Michiaki Unno, Toshinori Ito, Yoshiki Sawa, Hiromasa Tojo, Shin Egawa, Goutham Edula, Mary Lopez, Murray Wigmore, Naohiko Inase, Yasuyuki Yoshizawa, Fumio Nomura, György Marko-Varga

    Journal of Proteomics　74　(6)　759-764　2011/05/16

    DOI： 10.1016/j.jprot.2010.12.006 　

    ISSN： 1874-3919

  1760. 結腸運動制御における結腸内容物の役割

    菊地 大介, 柴田 近, 鹿郷 昌之, 木内 誠, 田中 直樹, 佐藤 学, 生澤 史江, 井本 博文, 染谷 崇徳, 海野 倫明, 佐々木 巖

    日本外科学会雑誌　112　(臨増1-2)　541-541　2011/05

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  1761. Cystic lymphangioma of the pancreas with spontaneous rupture: Report of a case

    Kei Kawaguchi, Fuyuhiko Motoi, Hideo Ohtsuka, Shoji Fukuyama, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Masahiro Satoh, Toru Asakura, Toru Shimosegawa, Michiaki Unno

    Case Reports in Gastroenterology　5　(2)　288-294　2011/05

    DOI： 10.1159/000326943 　

    ISSN： 1662-0631

  1762. 肝疾患 肝内胆管癌 (消化器外科学レビュー)

    吉田寛, 海野倫明

    消化器外科学レビュー　2011　87-91　2011/05

  1763. 【アトラスで学ぶ 達人の手術】 肝・胆・膵の手術 幽門輪温存膵頭十二指腸切除術 (消化器外科)

    元井冬彦, 海野倫明

    消化器外科　34　(6)　1009-1016　2011/05

  1764. 【経過を追えた小膵癌 この所見に気をつけろ!】 【症例呈示】 家族性膵癌 (肝胆膵画像)

    阿部永, 元井冬彦, 川口桂, 江川新一, 杉田純一, 海野倫明

    肝胆膵画像　13　(3)　269-275　2011/05

    DOI： 10.11477/mf.1428100393 　

  1765. 【胆嚢を究める】 基礎 胆嚢の症候学 (外科)

    深瀬耕二, 海野倫明

    外科　73　(5)　469-472　2011/05

  1766. 【胆道癌に対する最新の集学的治療】 胆管癌に対する術前化学放射線療法による集学的治療 (消化器内科)

    片寄友, 吉田寛, 中川圭, 森川孝則, 力山敏樹, 江川新一, 海野倫明

    消化器内科　52　(4)　420-424　2011/04

  1767. 【胆道・膵癌の治療 診療ガイドラインはどう変わるか?】 膵癌における外科手術 適応・術式の動向 (胆と膵)

    岡田恭穂, 江川新一, 元井冬彦, 乙供茂, 坂田直昭, 林洋毅, 吉田寛, 力山敏樹, 片寄友, 海野倫明

    胆と膵　32　(4)　301-307　2011/04

  1768. 【患者・家族の相談に応えるがん診療サポートガイド】 胆嚢・胆管がん かかりつけ医から専門医への質問 減黄術はどうしたらよいでしょうか? (治療)

    吉田寛, 海野倫明

    治療　93　(4月増刊)　908-909　2011/04

  1769. 効率よい胆管癌の術前診断 : 何が省略できるのか?

    真口 宏介, 海野 倫明

    胆道 = Journal of Japan Biliary Association　25　(1)　63-64　2011/03/31

    ISSN： 0914-0077

  1770. 膵癌術後補助療法の有効性予側を目的とした,バイオマーカーとしての血清CA19‐9動態の重要性

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　108　A181　2011/03/15

    ISSN： 0446-6586

  1771. MDCTの基本と有用性 (胆道)

    片寄友, 力山敏樹, 石田和之, 海野倫明

    胆道　25　(1)　53-59　2011/03

    DOI： 10.11210/tando.25.53 　

  1772. 【肝門部胆管癌の進展度と手術術式】 垂直方向進展と脈管の合併切除 MDCTによる門脈浸潤診断と門脈合併切除の成績・意義・適応 (肝胆膵画像)

    力山敏樹, 吉田寛, 林洋毅, 元井冬彦, 佐瀬友彦, 片寄友, 江川新一, 海野倫明

    肝胆膵画像　13　(2)　163-172　2011/03

    DOI： 10.11477/mf.1428100371 　

  1773. 鼠径ヘルニア還納後内翻したヘルニア嚢が索状物を形成し内ヘルニアを呈した1例

    三浦孝之, 田邊淳, 蛯名宣男, 荒木孝明, 高舘達之, 深瀬耕二, 大塚英郎, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本腹部救急医学会雑誌　31　(2)　339　2011/02/17

    ISSN： 1340-2242

  1774. A phase II multicenter trial of neoadjuvant chemotherapy FOLFOX6 in combination with bevacizumab for patients with resectable synchronous liver metastases after R0-resections of primary colorectal cancers: The interim analysis

    K. Miura, Y. Katayose, M. Oikawa, J. Yamauchi, N. Sakurai, H. Musha, Y. Narushima, K. Nakagawa, S. Egawa, M. Unno

    JOURNAL OF CLINICAL ONCOLOGY　29　(4)　2011/02

    ISSN： 0732-183X

    eISSN： 1527-7755

  1775. 【膵癌・胆道癌に対する免疫治療、ワクチン療法の新展開】 膵癌に対するWT1ペプチドワクチン治療の背景 (胆と膵)

    江川新一, 岡田恭穂, 林洋毅, 北村洋, 深瀬耕二, 乙供茂, 大塚英郎, 森川孝則, 水間正道, 坂田直昭, 中川圭, 吉田寛, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 海野倫明

    胆と膵　32　(2)　141-144　2011/02

  1776. 【肝・胆道系症候群(第2版) その他の肝・胆道系疾患を含めて 肝外胆道編】 肝外胆管(胆管、胆嚢管、総胆管) 炎症、感染症 慢性非化膿性破壊性胆管炎 (日本臨床)

    水間正道, 海野倫明

    日本臨床　別冊　(肝・胆道系症候群III)　23-26　2011/02

  1777. ATPアナログであるFSBAは多剤耐性関連トランスポーター、P-glycoproteinのモジュレーターである

    大沼忍, チューファン・エドアルド, サウナ・ズーベン, 三浦康, 柴田近, 海野倫明, 佐々木巌, アンバドカー・スレュシュ

    日本癌学会総会記事　70回　377-377　2011

  1778. 膵癌術前治療の有効性検証を目指した多施設共同研究:術前療法としてのgemcitabine+S1療法(GS療法)の第II相試験(Prep‐01)

    元井冬彦, 新地洋之, 松本逸平, 里井壮平, 谷眞至, 大東弘明, 庄雅之, 本田五郎, 和田慶太, 高原武志, 金光敬一郎, 乙供茂, 岡田恭穂, 中川圭, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　249　2011

  1779. MDCT‐3D画像を用いた肝胆膵高難度手術の術前診断とシミュレーション

    力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 林洋毅, 岡田恭穂, 森川孝則, 中川圭, 水間正道, 大塚英郎, 乙供茂, 深瀬耕二, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　263　2011

  1780. NACRAC(術前放射線化学療法:Neoadjuvant Chemoradiation therapy for cholangiocarcinoma)が奏功した進行胆管癌の病理検討からみた有効性と治療限界

    中川圭, 片寄友, 深瀬耕二, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 岡田恭穂, 林洋毅, 森川孝則, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　373　2011

  1781. 当科における膵体尾部切除術クリニカルパスの導入と運用評価

    岡田恭穂, 元井冬彦, 乙供茂, 坂田直昭, 深瀬耕二, 大塚英郎, 水間正道, 中川圭, 林洋毅, 森川孝則, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　319　2011

  1782. 膵良性および低悪性度腫瘍に対する腹腔鏡下膵切除術の適応と術式選択

    森川孝則, 内藤剛, 深瀬耕二, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　221　2011

  1783. 膵尾側切除術102例における術後膵瘻発症因子の検討

    森川孝則, 元井冬彦, 小野川徹, 深瀬耕二, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 岡田恭穂, 中川圭, 林洋毅, 吉田寛, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　237　2011

  1784. 膵液瘻術前術中リスク因子の検討および術後1病日リスク係数による膵液瘻発生予測とその対策

    乙供茂, 元井冬彦, 片寄友, 力山敏樹, 吉田寛, 小野川徹, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 大塚英郎, 坂田直昭, 水間正道, 深瀬耕二, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　199　2011

  1785. T2胆嚢癌に対する術式の検討

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 森川孝則, 岡田恭穂, 中川圭, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 深瀬耕二, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　227　2011

  1786. 十二指腸副乳頭部神経内分泌癌の1切除例

    堂地大輔, 大塚英郎, 深瀬耕二, 水間正道, 坂田直昭, 乙供茂, 中川圭, 林洋毅, 岡田恭穂, 吉田寛, 小野川徹, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　439　2011

  1787. 大腸癌同時性肝転移術前治療の検討―多施設共同第2相試験中間解析の結果から(Miyagi‐HBPCOG‐004)

    中川圭, 片寄友, 及川昌也, 山内淳一郎, 島村弘宗, 山本久仁治, 高橋賢一, 内山哲之, 高橋道長, 遠藤公人, 三浦康, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　177　2011

  1788. 全身投与化学療法による術前治療を用いた膵癌に対する治療戦略

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　174　2011

  1789. IPMN残膵再発からみた膵全摘術

    江川新一, 乙供茂, 深瀬耕二, 大塚英郎, 森川孝則, 水間正道, 坂田直昭, 林洋毅, 中川圭, 岡田恭穂, 吉田寛, 小野川徹, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　165　2011

  1790. 陽子線治療後にサルベージとして切除した局所進行膵頭部癌の1例

    吉松軍平, 元井冬彦, 坂田直昭, 松田泰史, 水間正道, 乙供茂, 中川圭, 林洋毅, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　380　2011

  1791. ゲムシタビンを用いた胆管癌に対する術前化学放射線治療の効果と安全性

    片寄友, 力山敏樹, 中川圭, 森川孝則, 吉田寛, 小野川徹, 林洋毅, 岡田恭穂, 大塚英郎, 水間正道, 乙供茂, 坂田直昭, 元井冬彦, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　247　2011

  1792. 肝門部胆管癌症例に対する周術期管理の工夫と手術治療成績

    吉田寛, 片寄友, 力山敏樹, 内藤剛, 元井冬彦, 小野川徹, 岡田恭穂, 森川孝則, 中川圭, 林洋毅, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 深瀬耕二, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　149　2011

  1793. 画像モダリティによる新しい移植膵島生着の評価法

    坂田直昭, 吉松軍平, 元井冬彦, 内藤剛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　222　2011

  1794. 巨大肝腫瘍を契機に発見された同時性多発肝転移を伴うSM結腸癌の一例

    土師陽一, 林洋毅, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 岡田恭穂, 中川圭, 森川孝則, 大塚英郎, 乙供茂, 坂田直昭, 水間正道, 深瀬耕二, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　411　2011

  1795. 胆管異所性開口により若年発症の難治性十二指腸潰瘍・総胆管結石を来した一例

    白崎圭一, 中川圭, 林洋毅, 乙供茂, 水間正道, 小野川徹, 森川孝則, 海野純, 下瀬川徹, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　23rd　421　2011

  1796. 大腸癌同時性肝転移術前治療の検討―多施設共同第2相試験中間解析の結果から(Miyagi‐HBPCOG‐004)

    及川昌也, 片寄友, 片寄友, 山内淳一郎, 島村弘宗, 山本久仁治, 高橋賢一, 中川圭, 中川圭, 三浦康, 三浦康, 江川新一, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　219(J‐STAGE)　2011

    ISSN： 1348-9372

  1797. 進行肝門部胆管癌における血管合併切除の治療成績と意義

    力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 林洋毅, 中川圭, 森川孝則, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　202(J‐STAGE)　2011

    ISSN： 1348-9372

  1798. 高齢者肝胆膵悪性腫瘍における外科治療

    深瀬耕二, 中川圭, 中川圭, 小野川徹, 吉田寛, 元井冬彦, 力山敏樹, 片寄友, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　561(J‐STAGE)　2011

    ISSN： 1348-9372

  1799. 肝・リンパ節転移を伴う膵神経内分泌腫瘍の治療成績と戦略

    中山瞬, 乙供茂, 江川新一, 片寄友, 力山敏樹, 元井冬彦, 吉田寛, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　313(J‐STAGE)　2011

    ISSN： 1348-9372

  1800. 膵瘻低下を目指した膵管空腸粘膜吻合:ステント留置の無作為比較試験と前向き検証試験を基に

    吉田寛, 元井冬彦, 乙供茂, 力山敏樹, 小野川徹, 岡田恭穂, 林洋毅, 片寄友, 片寄友, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　293(J‐STAGE)　2011

    ISSN： 1348-9372

  1801. 当教室における肝胆膵手術のSSI対策:至適腹腔内ドレナージ法と皮膚閉鎖法

    水間正道, 力山敏樹, 吉田寛, 中川圭, 林洋毅, 岡田恭穂, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　519(J‐STAGE)　2011

    ISSN： 1348-9372

  1802. GEM,S1時代の切除適応:大動脈周囲リンパ節転移陽性例と腹水洗浄細胞診陽性例に対して

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　203(J‐STAGE)　2011

    ISSN： 1348-9372

  1803. 切除可能胆管癌に対する術前化学放射線療法:第I相試験3年後の経過報告

    片寄友, 片寄友, 力山敏樹, 中川圭, 中川圭, 森川孝則, 吉田寛, 小野川徹, 林洋毅, 元井冬彦, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　666(J‐STAGE)　2011

    ISSN： 1348-9372

  1804. 膵全摘+自家膵島移植を行い,良好な耐糖能を得た急性膵炎合併膵動静脈奇形の1例

    坂田直昭, 後藤昌史, 後藤昌史, 元井冬彦, 山口賢, 林洋毅, 山谷英之, 関口悟, 江川新一, 里見進, 里見進, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　893(J‐STAGE)　2011

    ISSN： 1348-9372

  1805. 当科における膵尾側切除術施行例30例に対するretrospective cohort study

    森川孝則, 内藤剛, 内藤剛, 鹿郷昌之, 小野川徹, 元井冬彦, 力山敏樹, 片寄友, 柴田近, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　470(J‐STAGE)　2011

    ISSN： 1348-9372

  1806. 胆管癌における術前放射線化学療法の効果と意義

    中川圭, 片寄友, 水間正道, 岡田恭穂, 林洋毅, 元井冬彦, 力山敏樹, 江川新一, 海野倫明, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　222(J‐STAGE)　2011

    ISSN： 1348-9372

  1807. 胆道癌に対するHPDの適応と手技

    林洋毅, 力山敏樹, 元井冬彦, 吉田寛, 森川孝則, 岡田恭穂, 中川圭, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　289(J‐STAGE)　2011

    ISSN： 1348-9372

  1808. IPMN切除116例の治療成績

    乙供茂, 江川新一, 片寄友, 力山敏樹, 元井冬彦, 吉田寛, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　445(J‐STAGE)　2011

    ISSN： 1348-9372

  1809. 高齢者に対する膵頭十二指腸切除術のリスクファクター解析

    江川新一, 元井冬彦, 岡田恭穂, 乙供茂, 林洋毅, 中川圭, 吉田寛, 力山敏樹, 片寄友, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　233(J‐STAGE)　2011

    ISSN： 1348-9372

  1810. 膵頭十二指腸切除術における周術期管理の標準化は合併症発生・治療と在院日数に良い影響を与えたか?

    岡田恭穂, 元井冬彦, 中川圭, 林洋毅, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌(Web)　44　(Supplement1)　545(J‐STAGE)　2011

    ISSN： 1348-9372

  1811. Verification of Diagnostic Biomarker Candidates for Biliary Tract Carcinoma by SRM MS- based Multiple Assay

    Fukuda Tetsuya, Bando Yasuhiko, Unno Michiaki, Nishimura Toshihide, Maeda Shinpei, Onogawa Touru, Takadate Tatsuyuki, Mikami Sayaka, Morikawa Takanori, Rikiyama Toshiki, Katayori Yuu, Egawa Shinichi

    Abstracts for Annual Meeting of Japanese Proteomics Society　2011　(0)　174-174　2011

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    DOI： 10.14889/jhupo.2011.0.174.0 　

  1812. Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study).

    Katayose Yu, Rikiyama Toshiki, Motoi Fuyuhiko, Yamamoto Kuniharu, Yoshida Hiroshi, Morikawa Takanori, Hayashi Hiroki, Kanno Atsushi, Hirota Morihisa, Satoh Kennichi, Ariga Hisanori, Suzuki Masaki, Ohyauchi Motoki, Kondo Yutaka, Ikeya Shinichi, Ogawa Yoshihiro, Shimosegawa Tooru, Egawa Shinichi, Unno Michiaki

    Hepatogastroenterology　58　(112)　1866-1872　2011

    DOI： 10.5754/hge10106 　

  1813. 膵神経内分泌腫瘍の新WHO分類と病理組織学諸的因子の解析

    笠島敦子, 石田和之, 藤島史喜, 中村保宏, 渡辺みか, 元井冬彦, 大塚英郎, 海野倫明, 笹野公伸

    日本内分泌病理学会学術総会プログラム・抄録集　15th　31　2011

  1814. 高バリアンス手術である膵頭十二指腸切除クリティカルパスを円滑に導入し定着させる工夫

    岡田恭穂, 元井冬彦, 乙供茂, 森川孝則, 林洋毅, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本クリニカルパス学会誌　12　(4)　492　2010/11/01

  1815. 【先天性胆道拡張症、膵・胆管合流異常の常識を見直す】 先天性胆道拡張症、膵・胆管合流異常に対する術後の問題点 術後合併症からみた先天性胆道拡張症手術の問題点 (胆と膵)

    大塚英郎, 吉田寛, 元井冬彦, 片寄友, 力山敏樹, 江川新一, 海野倫明

    胆と膵　31　(11)　1319-1323　2010/11

  1816. 【知っておきたい癌取扱い規約のポイント 日本と世界の違い】 膵癌 (外科治療)

    乙供茂, 元井冬彦, 江川新一, 海野倫明

    外科治療　103　(5)　481-487　2010/11

  1817. 若年発症の巨大肝原発肉腫の1例

    中山瞬, 力山敏樹, 吉田寛, 小野川徹, 岡田恭穂, 中川圭, 林洋毅, 森川孝則, 大塚英郎, 乙供茂, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　732　2010/10/20

    ISSN： 1345-2843

  1818. 術前化学放射線療法施行後腹膜播種にて非切除となり2年間無増悪の胆管癌の一例

    土師陽一, 片寄友, 力山敏樹, 元井冬彦, 林洋毅, 中川圭, 岡田恭穂, 水間正道, 福原賢治, 横山忠明, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　698　2010/10/20

    ISSN： 1345-2843

  1819. 当科における膵頭十二指腸切除術クリニカルパスの導入とバリアンス解析

    岡田恭穂, 元井冬彦, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　797　2010/10/20

    ISSN： 1345-2843

  1820. 肝胆膵領域のSSI~発生減少と早期改善をめざして~

    中川圭, 力山敏樹, 吉田寛, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 岡田恭穂, 森川孝則, 林洋毅, 小野川徹, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　430　2010/10/20

    ISSN： 1345-2843

  1821. 膵癌における腹腔洗浄細胞診の臨床的意義

    乙供茂, 元井冬彦, 片寄友, 力山敏樹, 吉田寛, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　539　2010/10/20

    ISSN： 1345-2843

  1822. 膵癌に対する腹腔鏡下体尾部切除術導入に向けて―当教室での試み―

    森川孝則, 内藤剛, 鹿郷昌之, 木内誠, 安藤敏典, 小野川徹, 元井冬彦, 力山敏樹, 片寄友, 柴田近, 江川新一, 佐々木巌, 海野倫明

    日本臨床外科学会雑誌　71　421　2010/10/20

    ISSN： 1345-2843

  1823. 膵管ステント外瘻は,膵腸吻合の臨床症状を伴う膵瘻発生率を低下させる

    元井冬彦, 水間正道, 坂田直昭, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 岡田恭穂, 小野川徹, 吉田寛, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　71　326　2010/10/20

    ISSN： 1345-2843

  1824. 肝胆膵外科領域手術の閉創における真皮埋没縫合の有用性:Skin Stapleと比較して

    水間正道, 力山敏樹, 吉田寛, 小野川徹, 林洋毅, 中川圭, 岡田恭穂, 森川孝則, 大塚英郎, 乙供茂, 坂田直昭, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本外科感染症学会雑誌　7　(5)　487　2010/10/18

    ISSN： 1349-5755

  1825. 腹腔鏡下に修復した遅発性外傷性横隔膜ヘルニアの1例

    梶原 大輝, 内藤 剛, 小野川 徹, 吉田 寛, 森川 孝則, 乙供 茂, 木村 俊一, 鹿郷 昌之, 木内 誠, 安藤 敏典, 海野 倫明

    日本内視鏡外科学会雑誌　15　(7)　517-517　2010/10

    Publisher: (一社)日本内視鏡外科学会

    ISSN： 1344-6703

  1826. 膵癌に対する術前治療の意義

    元井冬彦, 乙供茂, 岡田恭穂, 中川圭, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　45　(2)　494　2010/09/21

    ISSN： 0021-4671

  1827. SSTR発現パターンからみた膵内分泌腫瘍肝転移巣におけるOctoreotide投与の有用性

    有明恭平, 元井冬彦, 大塚英郎, 石田和之, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　107　A957　2010/09/15

    ISSN： 0446-6586

  1828. 膵管融合不全を合併した膵・胆管合流異常症例の検討

    三浦孝之, 大塚英郎, 荒木孝明, 堂地大輔, 深瀬耕二, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本膵・胆管合流異常研究会プロシーディングス　33rd　51　2010/09/11

    ISSN： 1883-4116

  1829. 大腸癌同時性肝転移に対する肝切除前FOLFOX+BV療法 多施設共同第II相中間解析

    片寄 友, 三浦 康, 山内 淳一郎, 櫻井 直樹, 武者 宏昭, 柿田 哲也, 成島 陽一, 内山 哲之, 高橋 道長, 及川 昌也, 武藤 満完, 高橋 賢一, 中川 圭, 江川 新一, 海野 倫明

    日本癌治療学会誌　45　(2)　560-560　2010/09

    Publisher: (一社)日本癌治療学会

    ISSN： 0021-4671

  1830. CurABが得られたpT2胆嚢癌における胆管切除の意義

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 森川孝則, 中川圭, 大塚英郎, 水間正道, 深瀬耕二, 江川新一, 海野倫明

    胆道　24　(3)　447　2010/08/31

    ISSN： 0914-0077

  1831. リンパ濾胞形成による顆粒状隆起性病変を伴った広範囲胆管粘膜癌の1例

    高野成尚, 林洋毅, 吉田寛, 乙供茂, 中川圭, 石田和之, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 菅野敦, 佐藤賢一, 下瀬川徹, 海野倫明

    胆道　24　(3)　463　2010/08/31

    ISSN： 0914-0077

  1832. 胆管癌に対する術前化学放射線療法:第I相試験登録終了2年の経過

    片寄友, 力山敏樹, 元井冬彦, 小野川徹, 吉田寛, 森川孝則, 林洋毅, 岡田恭穂, 乙供茂, 大塚英郎, 坂田直昭, 中川圭, 水間正道, 深瀬耕二, 内藤剛, 菅野敦, 佐藤賢一, 江川新一, 下瀬川徹, 海野倫明

    胆道　24　(3)　457　2010/08/31

    ISSN： 0914-0077

  1833. IPNBで胆管切除後に遺残胆管再発を疑われた膵神経内分泌癌の1例

    堂地大輔, 片寄友, 力山敏樹, 元井冬彦, 小野川徹, 乙供茂, 岡田恭穂, 水間正道, 船場泰文, 石田和之, 江川新一, 海野倫明

    胆道　24　(3)　469　2010/08/31

    ISSN： 0914-0077

  1834. 胆道癌術後化学療法におけるゲムシタビン,および2nd lineとしてのS‐1の効果,安全性の検討

    大塚英郎, 片寄友, 力山敏樹, 元井冬彦, 吉田寛, 小野川徹, 林洋毅, 中川圭, 江川新一, 海野倫明

    胆道　24　(3)　458　2010/08/31

    ISSN： 0914-0077

  1835. 進行胆嚢癌に対するPD付加の適応と意義

    力山敏樹, 林洋毅, 吉田寛, 小野川徹, 森川孝則, 中川圭, 大塚英郎, 水間正道, 深瀬耕二, 元井冬彦, 片寄友, 江川新一, 海野倫明

    胆道　24　(3)　447　2010/08/31

    ISSN： 0914-0077

  1836. 【膵癌の長期生存の条件】 病期群別解析による膵癌切除例の長期生存の条件 (消化器内科)

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    消化器内科　51　(2)　173-179　2010/08

  1837. Recent progress and future perspective of medical examination and treatment for bile duct carcinoma

    Michiaki Unno

    Journal of Japanese Society of Gastroenterology　107　(7)　1081-1088　2010/07

    ISSN： 0446-6586

  1838. A Case of Pseudoaneurysm Within the Pseudocyst of Chronic Pancreatitis

    Manabu Sato, Shinichi Egawa, Shoji Fukuyama, Nobuo Ebina, Akihiko Harada, Fuyuhiko Motoi, Kiyoto Tsushima, Michiaki Unno, Iwao Sasaki

    PANCREAS　39　(5)　697-697　2010/07

    ISSN： 0885-3177

  1839. 多発膵腫瘍により膵全摘を余儀なくされインスリン導入となったVHL病の1例

    近藤 敬一, 檜尾 好徳, 丹治 泰裕, 工藤 宏仁, 突田 壮平, 石川 素子, 薄井 正寛, 冨永 竜, 長谷川 豊, 山口 賢, 石垣 泰, 荻原 健英, 片桐 秀樹, 元井 冬彦, 江川 新一, 海野 倫明, 藤島 史喜, 中村 保宏, 渡辺 みか, 岡 芳知

    糖尿病　53　(7)　523-523　2010/07

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  1840. 胆管癌診療の現状と課題 (日本消化器病学会雑誌)

    海野倫明

    日本消化器病学会雑誌　107　(7)　1081-1088　2010/07

    DOI： 10.11405/nisshoshi.107.1081 　

  1841. 【図解deまるわかり ケアにつなげる消化器外科の術式マニュアル】 肝葉切除術 (消化器外科Nursing)

    中川圭, 海野倫明

    消化器外科Nursing　15　(7)　727-731　2010/07

  1842. Management of liver metastases from colorectal cancer

    Yu Katayose, Michiaki Unno

    Clinical Journal of Gastroenterology　3　(3)　128-135　2010/06

    DOI： 10.1007/s12328-010-0155-z 　

    ISSN： 1865-7257 1865-7265

  1843. 消化器癌治療における癌性疼痛治療の重要性 フェンタニル貼付剤の使用法を中心に (新薬と臨床)

    海野倫明

    新薬と臨床　59　(6)　913-918　2010/06

  1844. 膵体尾部切除後残膵再発をきたし、残膵全摘を施行した膵管内乳頭粘液腺癌の2例

    三浦 孝之, 元井 冬彦, 小野川 徹, 山本 久二治, 吉田 寛, 大塚 英郎, 川口 桂, 有明 恭平, 藤川 奈々子, 石田 和之, 菅野 敦, 正宗 淳, 佐藤 賢一, 内山 哲之, 力山 敏樹, 片寄 友, 江川 新一, 下瀬川 徹, 海野 倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22回　316-316　2010/05

    Publisher: (一社)日本肝胆膵外科学会

  1845. 肝血管筋脂肪腫のFDG PET/CTと病理所見の比較

    荒井 晃, 平出 智道, 高浪 健太郎, 山田 章吾, 高橋 昭喜, 三田村 篤, 海野 倫明, 岡田 賢, 後藤 了以, 福田 寛

    核医学　47　(2)　180-181　2010/05

    Publisher: (一社)日本核医学会

    ISSN： 0022-7854

    eISSN： 2189-9932

  1846. 研修医・専修医・指導医それぞれの立場から見た魅力ある外科教育 大学病院における魅力ある外科とは チームとしての外科学教室運営

    江川 新一, 力山 敏樹, 深瀬 耕二, 水間 正道, 坂田 直昭, 乙供 茂, 大塚 英郎, 森川 孝則, 林 洋毅, 中川 圭, 岡田 恭穂, 小野川 徹, 吉田 寛, 元井 冬彦, 内藤 剛, 片寄 友, 田中 直樹, 柴田 近, 佐々木 巌, 海野 倫明

    日本外科系連合学会誌　35　(3)　438-438　2010/05

    Publisher: 日本外科系連合学会

    ISSN： 0385-7883

  1847. トランスポーター・酵素タンパク質同時定量法を用いた膵臓癌薬剤感受性機構の解明

    大峰健, 川口桂, 大槻純男, 江川新一, 海野倫明, 寺崎哲也

    薬剤学　70　(Supplement)　70　2010/04/20

    ISSN： 0372-7629

  1848. Quantitative targeted proteomics in pancreatic cancer: Combinations of enzyme and transporter protein expression are novel indicators for gemcitabine sensitivity

    Kei Kawaguchi, Fuyuhiko Motoi, Ken Ohmine, Hideo Ohtsuka, Sumio Ohtuki, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Tetsuya Terasaki, Michiaki Unno

    CANCER RESEARCH　70　2010/04

    DOI： 10.1158/1538-7445.AM10-2705 　

    ISSN： 0008-5472

    eISSN： 1538-7445

  1849. 膵内分泌腫瘍肝転移の治療

    江川新一, 有明恭平, 大塚英郎, 乙供茂, 森川孝則, 中川圭, 林洋毅, 吉田寛, 山本久仁治, 小野川徹, 赤田昌紀, 元井冬彦, 片寄友, 力山敏樹, 石田和之, 笹野公伸, 柴田近, 佐々木巌, 海野倫明

    日本内分泌外科学会総会プログラム・抄録集　22nd　80　2010/04

  1850. 若手呼吸器外科医のための気管支手術手技トレーニング

    渡辺 有為, 野田 雅史, 岡田 克典, 遠藤 千顕, 星川 康, 桜田 晃, 佐渡 哲, 小柳津 毅, 前田 寿美子, 大石 久, 上野 正博, 鈴木 隆哉, 中川 隆行, 野津田 泰嗣, 江場 俊介, 渡邉 龍秋, 近藤 丘, 海野 倫明, 笠井 憲雪

    日本呼吸器外科学会雑誌　24　(3)　489-489　2010/04

    Publisher: (NPO)日本呼吸器外科学会

    ISSN： 0919-0945

  1851. 【外科当直医必携】 救急外来当直医必携 救急・蘇生処置 皮内反応 (消化器外科)

    赤田昌紀, 海野倫明

    消化器外科　33　(5)　568-570　2010/04

  1852. 【マスターしておきたい手術のための基本手技 臓器切離と吻合法】 吻合法 胆道再建 (消化器外科)

    中川圭, 片寄友, 海野倫明

    消化器外科　33　(4)　483-492　2010/04

  1853. 肝疾患 肝内胆管癌 (消化器外科学レビュー)

    吉田寛, 海野倫明

    消化器外科学レビュー　2010　81-85　2010/04

  1854. 治療例の予後因子からみた膵癌術前治療の適応と意義

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　107　A164　2010/03/15

    ISSN： 0446-6586

  1855. 胆管癌に対する術前化学放射線療法による集学的治療

    片寄友, 江川新一, 海野倫明

    日本消化器病学会雑誌　107　A107　2010/03/15

    ISSN： 0446-6586

  1856. 定量的標的プロテオミクスによる膵臓癌薬剤感受性機構の解明

    大峰健, 川口桂, 大槻純男, 江川新一, 海野倫明, 寺崎哲也

    日本薬学会年会要旨集　130th　(1)　386　2010/03/05

    ISSN： 0918-9823

  1857. SF-059-5 LC-MS/MSによる網羅的蛋白質同時絶対定量法に基づく新規抗癌剤感受性予測とテーラーメード治療への応用(薬剤耐性-2,サージカルフォーラム,第110回日本外科学会定期学術集会)

    川口 桂, 元井 冬彦, 大峰 健, 大村 範幸, 大塚 英郎, 力山 敏樹, 片寄 友, 大槻 純男, 寺崎 哲也, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1858. OP-111-5 膵癌切除後,腫瘍マーカー正常化維持期間の臨床的意義(膵癌-3,一般口演,第110回日本外科学会定期学術集会)

    元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1859. OP-122-1 膵癌にCOX2 inhibitorは有効か?膵癌は外来性のprostaglandinを利用している(膵癌-4,一般口演,第110回日本外科学会定期学術集会)

    大村 範幸, Goggins Michael, 水間 正道, 乙供 茂, 大塚 英郎, 赤田 昌紀, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1860. OP-186-2 大腸癌肝転移切除例に対するmFOLFOX6補助化学療法の安全性に関する検討 : 多施設共同第II相臨床試験(大腸癌肝転移-1,一般口演,第110回日本外科学会定期学術集会)

    山本 久仁治, 片寄 友, 浅沼 拓, 阿南 陽二, 阿部 友哉, 井伊 貴幸, 伊藤 靖, 岩指 元, 遠藤 公人, 及川 昌也, 柿田 徹也, 佐藤 正幸, 島村 弘宗, 白相 悟, 竹村 真一, 武藤 満完, 横山 忠明, 成島 陽一, 中村 隆司, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1861. OP-279-7 GC-binding factor 2がもたらす癌細胞の転移・浸潤メカニズムの解明(腫瘍基礎-13,一般口演,第110回日本外科学会定期学術集会)

    有明 恭平, 大塚 英郎, 元井 冬彦, 大村 範幸, 川口 桂, 藤川 奈々子, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1862. OP-115-4 胆嚢癌におけるEGFR発現と病理学的因子および予後との関係(腫瘍基礎-10,一般口演,第110回日本外科学会定期学術集会)

    林 洋毅, 渡部 泰弘, 片寄 友, 力山 敏樹, 赤田 昌紀, 元井 冬彦, 山本 久仁治, 吉田 寛, 小野川 徹, 森川 孝則, 中川 圭, 乙供 茂, 大塚 英郎, 大村 範幸, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1863. OP-247-5 膵内分泌腫瘍肝転移例におけるSSTRの発現とその治療戦略(膵・集学的-1,一般口演,第110回日本外科学会定期学術集会)

    大塚 英郎, 有明 恭平, 元井 冬彦, 江川 新一, 片寄 友, 力山 敏樹, 赤田 昌紀, 山本 久仁治, 吉田 寛, 小野川 徹, 森川 孝則, 林 洋毅, 中川 圭, 乙供 茂, 大村 範幸, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1864. OP-285-8 肝胆膵外科領域におけるフォンダパリヌクス使用の検討(周術期管理-11,一般口演,第110回日本外科学会定期学術集会)

    森川 孝則, 片寄 友, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 小野川 徹, 山本 久仁治, 吉田 寛, 中川 圭, 林 洋毅, 大塚 英郎, 乙供 茂, 大村 範幸, 江川 新一, 海野 倫明

    日本外科学会雑誌　111　(2)　2010/03/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1865. マウス胎仔線維芽細胞におけるFbxw 7による細胞周期抑制因子の制御 (日本外科学会雑誌)

    益田邦洋, 石川善則, 山本久仁治, 片寄友, 小野山一郎, 中山敬一, 海野倫明, 中山啓子

    日本外科学会雑誌　111　(臨増2)　465-465　2010/03

  1866. 胆道専門医講座 胆管結石 胆道専門医に求められるスキル(知識と手技)(第一回) 疫学・病態 胆管結石の疫学と病態 (胆道)

    正田純一, 海野倫明

    胆道　24　(1)　127-134　2010/03

    Publisher: Japan Biliary Association

    DOI： 10.11210/tando.24.127 　

    ISSN： 0914-0077

    More details Close

    Gallstone disease is one of the most frequent biliary tract diseases that a biliary specialist often makes diagnosis and medical treatment. There are two national surveys in 1996 and 1997 by the Japan Biliary Association as epidermiology investigation of the gallstone disease. However, the recent trend is unknown without investigation being preformed for the past 10 years. In this article, we give an outline of the epidemiology of the choledocholithiasis and hepatolithiasis in Japan based on the national surveys. Moreover, we also review the pathogenesis of the cholesterol gallstone and calcium bilirubinate gallstone.<br>

  1867. 【神経内分泌腫瘍のUPDATE】 神経内分泌腫瘍の分子標的治療 (日本消化器病学会雑誌)

    海野倫明

    日本消化器病学会雑誌　107　(3)　392-395　2010/03

    Publisher: The Japanese Society of Gastroenterology

    DOI： 10.11405/nisshoshi.107.392 　

    ISSN： 0446-6586

  1868. 膵手術後の緊急を要する合併症

    赤田昌紀, 元井冬彦, 乙供茂, 中川圭, 林洋毅, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本腹部救急医学会雑誌　30　(2)　234　2010/02/18

    ISSN： 1340-2242

  1869. 急速な転帰を辿った気腫性膵炎の1例

    小松弘武, 吉田寛, 林洋毅, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本腹部救急医学会雑誌　30　(2)　352　2010/02/18

    ISSN： 1340-2242

  1870. [Diagnosis and treatment of liver metastases] (Gan To Kagaku Ryoho)

    Omura Noriyuki, Yamamoto Kuniharu, Katayose Yu, Egawa Shinichi, Unno Michiaki

    Gan To Kagaku Ryoho　37　(2)　194-199　2010/02

  1871. 【胆道癌の進展度診断と治療戦略】 MDCTによる胆管癌の長軸進展度診断と治療方針 (消化器内科)

    力山敏樹, 片寄友, 海野倫明

    消化器内科　50　(2)　145-150　2010/02

  1872. A PHASE II TRIAL OF HEPATECTOMY FOLLOWED BY MODIFIED FOLFOX6 AS TREATMENT FOR LIVER METASTASIS FROM COLORECTAL CANCER (MIYAGI HBPCOG 004): INTERIM ANALYSIS OF SAFETY

    Y. Katayose, K. Yamaoto, S. Takemura, T. Asamuna, H. Iwasashi, M. Mutoh, H. Shimamura, K. Nakagawa, S. Egawa, M. Unno

    ANNALS OF ONCOLOGY　21　70-70　2010

    ISSN： 0923-7534

  1873. 病院保管のホルマリン固定化永久組織からプロテオーム解析はどこまでできるか?~ナノテクノロジーによるTissue to serum&bile strategy~

    小野川徹, 前田晋平, 高舘達之, 竹村太郎, 三上紗弥香, 福田哲也, 山田誠子, 板東泰彦, 碓井史彦, 箕輪貴司, 花方信孝, 西村俊秀, 森川孝則, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　222　2010

  1874. 肝胆膵外科高度技能医を育てるためのシステムと指導医・指導的助手のあり方

    力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　133　2010

  1875. 術前化学放射線療法(Neoadjuvant Chemoradiation therapy for cholangiocarcinoma:NACRAC)開始後約3年での安全性と効果の検討

    片寄友, 力山敏樹, 山本久仁治, 吉田寛, 小野川徹, 森川孝則, 林洋毅, 中川圭, 大塚英郎, 乙供茂, 坂田直昭, 赤田昌紀, 元井冬彦, 菅野敦, 下瀬川徹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　208　2010

  1876. 肝門部胆管癌における至適術前減黄法―PTBD施行の有無は予後規定因子となる

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 森川孝則, 林洋毅, 中川圭, 大塚英郎, 乙供茂, 益田邦洋, 菅野敦, 江川新一, 下瀬川徹, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　271　2010

  1877. 膵内分泌腫瘍肝転移症例に対するOctreotide投与の検討

    有明恭平, 元井冬彦, 大塚英郎, 川口桂, 藤川奈々子, 三浦孝之, 石田和之, 片寄友, 力山敏樹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　245　2010

  1878. 膵頭十二指腸切除術の膵空腸吻合における膵管ステントの膵瘻予防に対する有効性の検証:単一術者による無作為化比較試験報告

    元井冬彦, 乙供茂, 大塚英郎, 森川孝則, 林洋毅, 中川圭, 吉田寛, 小野川徹, 山本久仁治, 赤田昌紀, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　230　2010

  1879. FFPE組織を用いた網羅的プロテオーム解析による胆道癌新規バイオマーカーの探索

    前田晋平, 小野川徹, 高舘達之, 森川孝則, 竹村太郎, 三上紗弥香, 山田誠子, 福田哲也, 板東泰彦, 碓井史彦, 箕輪貴司, 花方信孝, 西村俊秀, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　325　2010

  1880. 再発膵癌の3次化学療法―Gemcitabine,S‐1不応例に対するmFOLFOX6奏効例の経験

    小松弘武, 元井冬彦, 山本久仁治, 乙供茂, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　423　2010

  1881. 当科における腹腔鏡下膵切除術施行例20例の検討

    森川孝則, 内藤剛, 鹿郷昌之, 小野川徹, 坂田直昭, 前田晋平, 高舘達之, 小松弘武, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　312　2010

  1882. ホルマリン固定パラフィン包埋組織を用いた臨床プロテオミクスによる膵癌新規バイオマーカーの探索

    高舘達之, 小野川徹, 前田晋平, 元井冬彦, 森川孝則, 竹村太郎, 三上紗弥香, 山田誠子, 福田哲也, 板東泰彦, 碓井史彦, 箕輪貴司, 花方信孝, 西村俊秀, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　383　2010

  1883. 膵癌術前化学療法としてのGemcitabine+TS1療法(GS療法)の安全性・有効性の検証:NAC GS第II相臨床試験 第1次報告

    元井冬彦, 乙供茂, 及川昌也, 岡田恭穂, 内山哲之, 井伊貴幸, 竹村真一, 岩指元, 島村弘宗, 赤田昌紀, 佐藤賢一, 片寄友, 江川新一, 下瀬川徹, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　22nd　150　2010

  1884. 胆道癌術後補助化学療法におけるGEM投与,再発に対する2nd line:S‐1の効果,安全性の検討

    大塚英郎, 益田邦洋, 北村洋, 乙供茂, 吉田寛, 山本久仁治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　244(J‐STAGE)　2010

    ISSN： 0386-9768

  1885. 当科における非B非C型HCCの切除成績に関する検討

    山本久仁治, 高舘達之, 大塚英郎, 吉田寛, 小野川徹, 乙供茂, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　760(J‐STAGE)　2010

    ISSN： 0386-9768

  1886. 進行膵頭部癌に対するR0切除率向上を目指した神経叢・後腹膜一括郭清(PD en‐bloc)の意義

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　379(J‐STAGE)　2010

    ISSN： 0386-9768

  1887. 当科における十二指腸乳頭部癌の治療戦略

    森川孝則, 力山敏樹, 小野川徹, 前田晋平, 高舘達之, 小松弘武, 元井冬彦, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　373(J‐STAGE)　2010

    ISSN： 0386-9768

  1888. MDCTによる肝門部胆管癌進展度診断と断端陰性を目指した門脈合併切除ならびにNACRTの意義

    力山敏樹, 片寄友, 元井冬彦, 赤田昌紀, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　432(J‐STAGE)　2010

    ISSN： 0386-9768

  1889. 切除6年後に残膵再発を来たした膵癌の一例

    赤田昌紀, 江川新一, 中川圭, 林洋毅, 乙供茂, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　567(J‐STAGE)　2010

    ISSN： 0386-9768

  1890. FFPE(ホルマリン固定パラフィン包埋)標本からのプロテオミクス

    海野倫明, 小野川徹, 前田晋平, 高館達之, 森川孝則, 江川新一, 片寄友, 片寄友

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　170(J‐STAGE)　2010

    ISSN： 0386-9768

  1891. 腫瘤形成型肝内胆管癌の手術成績からみた治療戦略

    吉田寛, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 乙供茂, 片寄友, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　241(J‐STAGE)　2010

    DOI： 10.5833/jjgs.43.241 　

    ISSN： 0386-9768

  1892. 薬剤耐性の進行・再発膵癌に対する抗癌剤を併用したWT1ペプチドワクチン療法

    江川新一, 赤田昌紀, 林洋毅, 北村洋, 嶋健太郎, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　384(J‐STAGE)　2010

    ISSN： 0386-9768

  1893. 当科におけるT2胆嚢癌の治療方針

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 小野川徹, 江川新一, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　375(J‐STAGE)　2010

    ISSN： 0386-9768

  1894. 当科切除例における膵腺扁平上皮癌の臨床組織学的検討

    小松弘武, 江川新一, 元井冬彦, 小野川徹, 森川孝則, 坂田直昭, 力山敏樹, 海野倫明

    日本消化器外科学会雑誌　43　(Supplement1 (Web))　568(J‐STAGE)　2010

    ISSN： 0386-9768

  1895. 胆道癌 FFPE 組織を用いた網羅的プロテオーム解析による新規バイオマーカーの探索と検証

    前田 晋平, 板東 泰彦, 碓井 史彦, 高舘 達之, 森川 孝則, 力山 敏樹, 片寄 友, 江川 新一, 箕輪 貴司, 花方信孝, 西村 俊秀, 小野川 徹, 海野 倫明, 三上 紗弥香, 竹村 太郎, 前田 めぐみ, 福田 哲也, 遠藤 洋子, 山田 誠子, 西山 隆太郎

    日本プロテオーム学会大会要旨集　2010　(0)　70-70　2010

    Publisher: 日本プロテオーム学会（日本ヒトプロテオーム機構）

    DOI： 10.14889/jhupo.2010.0.70.1 　

  1896. FFPE 組織を用いたレトロスペクティブプロテオミクスによる膵癌新規予後予測マーカーの探索

    高舘 達之, 前田 めぐみ, 山田 誠子, 福田 哲也, 板東 泰彦, 碓井 史彦, 力山 敏樹, 片寄 友, 江川 新一, 花方 信孝, 西村 俊秀, 小野川 徹, 海野 倫明, 藤井 清永, 元井 冬彦, 前田 晋平, 森川 孝則, 竹村 太郎, 箕輪 貴司, 三上 紗弥香

    日本プロテオーム学会大会要旨集　2010　(0)　91-91　2010

    Publisher: 日本プロテオーム学会（日本ヒトプロテオーム機構）

    DOI： 10.14889/jhupo.2010.0.91.2 　

  1897. 胆膵 胆汁酸トランスポーター 基礎と臨床 (Annual Review消化器)

    海野倫明, 阿部高明

    Annual Review消化器　2010　255-260　2010/01

  1898. 当科における肝膵同時切除(HPD)症例の検討

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 小野川徹, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 大村範幸, 益田邦洋, 江川新一, 海野倫明

    東北医学雑誌　121　(2)　212-213　2009/12/25

    ISSN： 0040-8700

  1899. トランスポーターと癌 (最新トランスポーター研究2009)

    鈴木健弘, 海野倫明, 阿部高明

    最新トランスポーター研究2009　140-141　2009/12

  1900. 胆道再建を伴う肝切除術における至適ドレーン―前向きランダム化比較試験とその後連続15症例からの検討―

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 森川孝則, 林洋毅, 中川圭, 大塚英郎, 乙供茂, 大村範幸, 江川新一, 海野倫明

    日本外科感染症学会雑誌　6　(5)　486　2009/11/09

    ISSN： 1349-5755

  1901. 膵術後に発症し,弁置換術施行するも救命しえなかったMRSA感染性心内膜炎の1例

    小松弘武, 吉田寛, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 江川新一, 海野倫明

    日本外科感染症学会雑誌　6　(5)　576　2009/11/09

    ISSN： 1349-5755

  1902. The Experiences of Internal Drainage of Pancreatic Pseudocysts Accomplished by Minimally Invasive Laparoscopic Approaches

    S. Fukuyama, K. Takeda, S. Egawa, H. Tokumura, M. Unno, S. Matsuno

    PANCREAS　38　(8)　997-997　2009/11

    ISSN： 0885-3177

  1903. Prognostic Relevance of Morphologic Types of Intraductal Papillary Mucinous Neoplasms of the Pancreas

    T. Furukawa, T. Hatori, I. Fujita, M. Yamamoto, M. Kobayashi, N. Ohike, T. Morohoshi, S. Egawa, M. Unno, S. Takao, M. Osako, S. Yonezawa, M. Mino-Kenudson, G. Y. Lauwers, H. Yamaguchi, S. Ban, M. Shimizu

    PANCREAS　38　(8)　998-998　2009/11

    ISSN： 0885-3177

  1904. Prospects of Tailor-Made Chemotherapy Based on Proteomics Technology

    K. Kawaguchi, F. Motoi, N. Fujikawa, K. Ariake, S. Yokoyama, N. Omura, H. Otsuka, T. Rikiyama, Y. Katayose, S. Egawa, M. Unno

    PANCREAS　38　(8)　1014-1014　2009/11

    ISSN： 0885-3177

  1905. Expression of MSX2 Predicts the Malignancy of Branch Duct Intraductal Papillary Mucinous Neoplasm of the Pancreas

    K. Satoh, S. Hamada, A. Kanno, M. Hirota, H. Ito, S. Egawa, F. Moti, M. Unno, T. Shimosegawa

    PANCREAS　38　(8)　1043-1044　2009/11

    ISSN： 0885-3177

  1906. Paclitaxel as a Salvage Chemotherapy in Patients With Gemcitabine-Refractory Pancreatic Cancer

    S. Maeda, F. Motoi, K. Kawaguchi, T. Onogawa, T. Morikawa, A. Okaue, T. Takadate, T. Rikiyama, Y. Katayose, S. Egawa, M. Unno

    PANCREAS　38　(8)　1024-1024　2009/11

    ISSN： 0885-3177

  1907. CA19‐9非上昇通常型膵癌におけるDUPAN‐2測定の意義

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本臨床外科学会雑誌　70　669　2009/10/20

    ISSN： 1345-2843

  1908. 【胆道癌における進展度診断の新展開】 (癌の臨床)

    海野倫明, 菅野敦, 力山敏樹, 片寄友, 江川新一, 下瀬川徹

    癌の臨床　55　(7)　487-491　2009/10

  1909. 病期群別解析による膵癌切除例長期生存の条件

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　106　A641　2009/09/15

    ISSN： 0446-6586

  1910. プロテオミクス技術に基づくtailormade chemotherapyの展望

    川口桂, 元井冬彦, 藤川奈々子, 有明恭平, 横山智, 大塚英郎, 力山敏樹, 片寄友, 大峰健, 大槻純男, 寺崎哲也, 江川新一, 海野倫明

    日本癌治療学会誌　44　(2)　297　2009/09/14

    ISSN： 0021-4671

  1911. Gemcitabine不応進行・再発膵癌に対するPaclitaxel化学療法の有用性と安全性の検討

    前田晋平, 元井冬彦, 小野川徹, 森川孝則, 岡上能斗竜, 高舘達之, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　44　(2)　437　2009/09/14

    ISSN： 0021-4671

  1912. 膵胆道癌に対する術前治療の戦略:安全性・有効性の検証

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　44　(2)　672　2009/09/14

    ISSN： 0021-4671

  1913. 【消化管癌Update 研究・診断・治療・予防の進歩】 消化管癌治療 大腸癌の外科治療・集学的治療 (医学のあゆみ)

    海野倫明

    医学のあゆみ　230　(10)　906-910　2009/09

  1914. 肝門部胆管癌症例に対する術前胆道ドレナージ

    吉田寛, 海野倫明, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 森川孝則, 林洋毅, 中川圭, 大塚英郎, 乙供茂, 大村範幸, 江川新一

    胆道　23　(3)　452　2009/08/31

    ISSN： 0914-0077

  1915. 術前に診断し得なかった胆嚢癌~予後および追加切除の意義~

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 吉田寛, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 大村範幸, 江川新一, 海野倫明

    胆道　23　(3)　467　2009/08/31

    ISSN： 0914-0077

  1916. ゲムシタビンによる胆道癌術後補助化学療法の現状

    大塚英郎, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 吉田寛, 森川孝則, 林洋毅, 中川圭, 乙供茂, 大村範幸, 江川新一, 海野倫明

    胆道　23　(3)　492　2009/08/31

    ISSN： 0914-0077

  1917. 術前診断で上部肝門部胆管癌が疑われたMirizzi症候群の1例

    高野成尚, 山本久仁治, 中川圭, 乙供茂, 力山俊樹, 片寄友, 江川新一, 海野倫明

    胆道　23　(3)　545　2009/08/31

    ISSN： 0914-0077

  1918. 肝葉切除を必要とする肝門部・上部胆管癌に対する術前化学放射線療法

    片寄友, 力山敏樹, 森川孝則, 岡上能斗竜, 山本久仁治, 吉田寛, 林洋毅, 中川圭, 大塚英郎, 乙供茂, 大村範幸, 元井冬彦, 江川新一, 海野倫明

    胆道　23　(3)　513　2009/08/31

    ISSN： 0914-0077

  1919. 胆管内乳頭状腫瘍の概念における組織学的粘液産生の意義

    森川孝則, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 小野川徹, 山本久仁治, 吉田寛, 中川圭, 林洋毅, 大塚英郎, 乙供茂, 大村範幸, 江川新一, 海野倫明

    胆道　23　(3)　449　2009/08/31

    ISSN： 0914-0077

  1920. 結腸直腸癌において、GCF2はリゾホスファチジン酸誘導RhoA活性と細胞浸潤に重要な役割を果たす(GCF2 has an important role in lysophosphatidic acid induced RhoA activation and cell invasion in colorectal cancer)

    有明 恭平, 大塚 英郎, 元井 冬彦, 及川 昌也, 力山 敏樹, 川口 桂, 藤川 奈々子, 片寄 友, 江川 新一, 海野 倫明

    日本癌学会総会記事　68回　425-425　2009/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  1921. 胆道癌の診断治療に有用な画像と外科解剖 MDCT cholangiographyによる胆道形態の検討

    北見 昌広, 高橋 昭喜, 海野 倫明

    胆道　23　(3)　343-343　2009/08

    Publisher: 日本胆道学会

    ISSN： 0914-0077

  1922. 【知っておくべき消化器手術の再建法】 肝外胆道切除術後の胆道再建法 (外科)

    中川圭, 吉田寛, 海野倫明

    外科　71　(8)　845-849　2009/08

    Publisher: 南江堂

    ISSN： 0016-593X

  1923. 【胆嚢癌根治手術をめぐる諸問題】 [術式選択] 進行胆嚢癌の進展様式に応じた術式選択と手術成績 (臨床外科)

    力山敏樹, 林洋毅, 片寄友, 海野倫明

    臨床外科　64　(8)　1039-1048　2009/08

    DOI： 10.11477/mf.1407102650 　

  1924. P-2-552 通常型膵癌切除後・腫瘍マーカー非正常化は,重要な予後不良因子である(膵癌予後,一般演題(ポスター),第64回日本消化器外科学会総会)

    元井 冬彦, 島村 弘宗, 石山 秀一, 及川 昌也, 桜井 直樹, 阿南 陽二, 中村 隆司, 内山 哲之, 丹野 弘晃, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　1271-1271　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1925. 進行・再発膵癌に対する免疫療法

    赤田昌紀, 江川新一, 元井冬彦, 乙供茂, 林洋毅, 中川圭, 塚本信和, 力山敏樹, 片寄友, 海野倫明

    日本消化器外科学会雑誌　42　(7)　980　2009/07/01

    ISSN： 0386-9768

  1926. SY-5-7 肝門部胆管癌に対して術前化学放射線療法を施行した19例の検討(シンポジウム5 肝門部胆管癌に対する集学的治療の進歩,第64回日本消化器外科学会総会)

    片寄 友, 力山 敏樹, 森川 孝則, 元井 冬彦, 山本 久仁治, 小野川 徹, 吉田 寛, 赤田 昌紀, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1927. PD-5-7 慢性膵炎に対するFrey手術後の長期成績(パネルディスカッション5 慢性膵炎治療の長期成績-保存的治療vs外科的治療-,第64回日本消化器外科学会総会)

    江川 新一, 坂田 直昭, 乙供 茂, 大塚 英郎, 山本 久仁治, 赤田 昌紀, 元井 冬彦, 力山 敏樹, 片寄 友, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1928. WS-1-8 進行・再発膵癌に対する免疫療法(ワークショップ1 消化器外科領域における免疫化学療法の新展開,第64回日本消化器外科学会総会)

    赤田 昌紀, 江川 新一, 元井 冬彦, 乙供 茂, 林 洋毅, 中川 圭, 塚本 信和, 力山 敏樹, 片寄 友, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1929. WS-7-1 脾温存膵体尾部切除の適応と工夫(ワークショップ7 尾側膵切除における脾温存の適応と成績,第64回日本消化器外科学会総会)

    乙供 茂, 江川 新一, 片寄 友, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 山本 久仁治, 吉田 寛, 小野川 徹, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1930. WS-8-5 膵・胆管合流異常,先天性胆道拡張症に対する分流手術術後合併症と手術術式の検討(ワークショップ8 膵管胆管合流異常症における手術適応と再建術式,第64回日本消化器外科学会総会)

    大塚 英郎, 片寄 友, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 山本 久仁治, 吉田 寛, 小野川 徹, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1931. RS-27-5 門脈塞栓時の大建中湯内服が,非塞栓葉の容積増大に及ぼす影響(要望演題27 消化器外科における漢方の役割,第64回日本消化器外科学会総会)

    林 洋毅, 片寄 友, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 山本 久仁治, 吉田 寛, 小野川 徹, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1932. P-1-428 FDG-PETによる胆管癌の局所浸潤評価について(胆 基礎・画像,一般演題(ポスター),第64回日本消化器外科学会総会)

    山本 久仁治, 片寄 友, 力山 敏樹, 吉田 寛, 乙供 茂, 佐藤 龍一郎, 益田 邦洋, 北村 洋, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1933. P-2-535 膵頭十二指腸切除・膵尾側切除を行い,膵体部を温存しえた膵頭部・尾部動静脈奇形の一例(膵 嚢胞性腫瘍・他,一般演題(ポスター),第64回日本消化器外科学会総会)

    荒木 孝明, 江川 新一, 片寄 友, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 山本 久二治, 吉田 寛, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1934. P-3-283 画像上膵癌との鑑別が困難であり,特異な病理像を呈した下部胆管腫瘍の1切除例(胆 症例5,一般演題(ポスター),第64回日本消化器外科学会総会)

    高舘 達之, 小野川 徹, 森川 孝則, 岡上 能斗竜, 前田 晋平, 元井 冬彦, 力山 敏樹, 片寄 友, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　42　(7)　2009/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1935. Borderline resectable cancerに対する治療戦略:術前治療と後腹膜一括郭清の意義

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　24　(3)　398　2009/06/30

    ISSN： 0913-0071

  1936. 抗癌剤耐性膵癌に対するWT1ペプチドワクチン治療

    江川新一, 赤田昌紀, 北村洋, 嶋健太郎, 川口桂, 塚本信和, 乙供茂, 大塚英郎, 岡田恭穂, 森川孝則, 林洋毅, 吉田寛, 小野川徹, 山本久仁治, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    すい臓　24　(3)　385　2009/06/30

    ISSN： 0913-0071

  1937. 腎癌膵転移3切除例の検討

    嶋健太郎, 赤田昌紀, 塚本信和, 中川圭, 林洋毅, 山本久仁治, 元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    すい臓　24　(3)　432　2009/06/30

    ISSN： 0913-0071

  1938. 膵切除におけるMDCT門脈浸潤評価の意義

    乙供茂, 元井冬彦, 片寄友, 力山敏樹, 赤田昌紀, 山本久仁治, 吉田寛, 江川新一, 海野倫明

    すい臓　24　(3)　325　2009/06/30

    ISSN： 0913-0071

  1939. 【がん診療update】 主要症候・検査所見から診断へのアプローチ 腹痛 (日本医師会雑誌)

    海野倫明

    日本医師会雑誌　138　(特別1)　S55-S56　2009/06

  1940. 【イラストでカンタン理解!消化器外科疾患30の病態生理とケア】 その他消化器症状別 腹水 (消化器外科Nursing)

    林洋毅, 海野倫明

    消化器外科Nursing　(2009春季増刊)　281-288　2009/04

  1941. HP-218-8 幽門輪温存膵頭十二指腸切除術と亜全胃温存膵頭十二指腸切除術の周術期比較(膵(臨床6),ハイブリッドポスター,第109回日本外科学会定期学術集会)

    北村 洋, 江川 新一, 山本 久仁治, 吉田 寛, 乙供 茂, 赤田 昌紀, 阿部 永, 森川 孝則, 林 洋毅, 大塚 英郎, 元井 冬彦, 力山 敏樹, 片寄 友, 海野 倫明

    日本外科学会雑誌　110　(2)　756-756　2009/02/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1942. SF-011-3 当科における胆管内乳頭状腫瘍の臨床病理学的検討(胆管・胆嚢(臨床病理),サージカルフォーラム,第109回日本外科学会定期学術集会)

    森川 孝則, 片寄 友, 岡上 能斗竜, 前田 晋平, 元井 冬彦, 力山 敏樹, 江川 新一, 海野 倫明

    日本外科学会雑誌　110　(2)　2009/02/25

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1943. 当科における胆管内乳頭状腫瘍の臨床病理学的検討 (日本外科学会雑誌)

    森川孝則, 片寄友, 岡上能斗竜, 前田晋平, 元井冬彦, 力山敏樹, 江川新一, 海野倫明

    日本外科学会雑誌　110　(臨増2)　237-237　2009/02

  1944. Molecular Divergence within Synchronous and Metachronous Intraductal Papillary Mucinous Neoplasms

    L. Stoll, J. K. Ryu, E. Chen, S. Egawa, M. Ishida, M. Akada, F. Motoi, M. Unno, R. D. Schulick, T. Furukawa, R. H. Hruban, A. Maitra

    LABORATORY INVESTIGATION　89　323A-323A　2009/01

    ISSN： 0023-6837

  1945. Molecular Divergence within Synchronous and Metachronous Intraductal Papillary Mucinous Neoplasms

    L. Stoll, J. K. Ryu, E. Chen, S. Egawa, M. Ishida, M. Akada, F. Motoi, M. Unno, R. D. Schulick, T. Furukawa, R. H. Hruban, A. Maitra

    MODERN PATHOLOGY　22　323A-323A　2009/01

    ISSN： 0893-3952

  1946. [The possibility of local control of cancer by neoadjuvant chemoradiation therapy with gemcitabine and surgical resection for advanced cholangiocarcinoma].

    Nakagawa Kei, Katayose Yu, Rikiyama Toshiki, Okaue Adoru, Unno Michiaki

    Gan To Kagaku Ryoho　36　(12)　2009-2011　2009

  1947. 難治性の肝・胆道疾患に関する調査研究 肝内結石症発癌WG報告 肝内結石症からの発癌機構の解明と発癌予測バイオマーカーの探索

    中沼安二, 梛野正人, 田妻進, 本多政夫, 山上裕機, 海野倫明, 正田純一, 佐田尚宏, 森俊之, 八坂貴宏

    難治性の肝・胆道疾患に関する調査研究 平成20年度 総括・分担研究報告書　29-31　2009

  1948. 大腸癌肝転移切除例におけるFOLFOX時代の影響

    山本久仁治, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 小野川徹, 吉田寛, 森川孝則, 林洋毅, 中川圭, 乙供茂, 大塚英郎, 佐藤龍一郎, 益田邦洋, 北村洋, 荒木孝明, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　214　2009

  1949. 術前治療を行い切除した上腸間膜静脈浸潤を伴う“Borderline resectable”膵頭部癌の2例

    嶋健太郎, 元井冬彦, 塚本信和, 中川圭, 林洋毅, 赤田昌紀, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　378　2009

  1950. 慢性膵炎急性増悪をきたした複雑型膵胆管合流異常,先天性胆道拡張症に対し膵頭十二指腸切除術を施行した2例

    荒木孝明, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久二治, 吉田寛, 小野川徹, 中川圭, 林洋毅, 森川孝則, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　410　2009

  1951. 肝胆膵外科に感じる魅力と高度技能医制度に対する期待

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 林洋毅, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　131　2009

  1952. 上腸間膜静脈浸潤を認めた膵漿液性嚢胞腫瘍を有するVHLの1例

    北村洋, 元井冬彦, 山本久仁治, 吉田寛, 乙供茂, 佐藤龍一郎, 益田邦洋, 荒木孝明, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　383　2009

  1953. 切除後再発膵癌の三次・四次化学療法‐gemcitabine,TS1不応症例に対するpaclitaxel,FOLFOX療法の経験

    前田晋平, 元井冬彦, 森川孝則, 岡上能斗竜, 高舘達之, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　312　2009

  1954. 当科における膵内分泌腫瘍肝転移症例の検討

    有明恭平, 元井冬彦, 大塚英郎, 横山智, 川口桂, 藤川奈々子, 片寄友, 力山敏樹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　381　2009

  1955. 膵粘液性嚢胞腫瘍の外科治療

    乙供茂, 元井冬彦, 片寄友, 力山敏樹, 赤田昌紀, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 中川圭, 大塚英郎, 岡上能斗竜, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　319　2009

  1956. 肝門部胆管癌の治療戦略と術式選択・切除成績

    力山敏樹, 片寄友, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 小野川徹, 林洋毅, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　177　2009

  1957. Stage III以上の胆嚢癌切除症例78例の検討

    林洋毅, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 小野川徹, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　171　2009

  1958. 慢性膵炎に対するFrey手術のインフォームドコンセント

    江川新一, 乙供茂, 大塚英郎, 中川圭, 森川孝則, 林洋毅, 吉田寛, 小野川徹, 山本久仁治, 赤田昌紀, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　336　2009

  1959. 初診時より2年を経過して治癒切除し得た肝内胆管癌の1例

    森川孝則, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田寛, 中川圭, 林洋毅, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　394　2009

  1960. Phase I trial of neoadjuvant chemoradiation therapy with surgical resection for cholangiocarcinoma patients

    片寄友, 力山敏樹, 山本久仁治, 元井冬彦, 赤田昌紀, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　123　2009

  1961. 膵臓外科周術期血糖管理におけるIntensive Insulin Therapyの有用性

    大塚英郎, 元井冬彦, 吉田寛, 片寄友, 力山敏樹, 赤田昌紀, 山本久仁治, 小野川徹, 森川孝則, 林洋毅, 中川圭, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　333　2009

  1962. 胆道再建を伴う肝切除術における至適ドレナージ法の検討:A prospective randomized trial―最終報告

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 小野川徹, 林洋毅, 森川孝則, 中川圭, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　330　2009

  1963. 脾静脈浸潤をきたした悪性solid pseudopapillary tumorの一例

    藤川奈々子, 元井冬彦, 大塚英郎, 横山智, 川口桂, 有明恭平, 片寄友, 力山敏樹, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　432　2009

  1964. Stage IV膵癌切除例の予後因子からみた進行膵癌外科治療戦略の再考

    元井冬彦, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　21st　324　2009

  1965. Discovery proteomics using formalin-fixed paraffin-embedded tissues of cholangiocarcinoma

    Onogawa Tohru, Yamada Seiko, Nishiyama Ryutaro, Minowa Takashi, Hanagata Nobutaka, Bando Yasuhiko, Usui Fumihiko, Nishimura Toshihide, Rikiyama Toshiki, Katayose Yu, Egawa Shinichi, Maeda Shimpei, Unno Michiaki, Okaue Adoru, Morikawa Takanori, Takadate Tatsuyuki, Maeda Megumi, Takemura Taro, Mikami Sayaka, Endo Yoko

    Abstracts for Annual Meeting of Japanese Proteomics Society　2009　(0)　91-91　2009

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    More details Close

    Cholangiocarcinoma status is highly associated with the overall survival of patients; yet, little is known about proteomic changes during tumor progression. To better understand the changes in protein expression involved in cholangiocarcinoma progression, and to identify potential biomarkers, we conducted a global quantitative proteomic analysis on archival cholangiocarcinomas. A total of 7 early stage, 12 advanced stage and 8 normal were assessed. Proteins were extracted from laser captured microdissected formalin fixed paraffin-embedded archival tissues by liquefying tissue cells. These preparations were analyzed by a LC/MS-based label-free protein quantification method. More than 1000 proteins were identified in the tissue lysates with a peptide ID confidence level of &gt;75%. This approach identified 149 significant changes in protein levels. These proteins were identified from multiple peptides with high confidence identification and were expressed at significantly different levels in staging as compared with normal bile duct.

  1966. 先天性胆道拡張症分流手術後の遺残膵内胆管癌-自験例例と本邦報告例の検討

    前田晋平, 片寄 友, 森川 孝則, 岡上 能斗竜, 力山 敏樹, 元井 冬彦, 赤田 昌紀, 山本 久仁治, 吉田 寛, 林 洋毅, 阿部 永, 乙供 茂, 大塚 英郎, 江川 新一, 海野 倫明

    日外会誌　110　236-236　2009

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  1967. [Analysis of patients with locally advanced gastric cancer undergoing gastrectomy after pre-operative chemotherapy including S-1]

    Kinouchi Makoto, Shibata Chikashi, Miura Koh, Okabe Mitsunori, Andou Toshinori, Kakyou Masayuki, Saijou Fumito, Haneda Sho, Ogawa Hitoshi, Unno Michiaki, Sasaki Iwao

    Gan To Kagaku Ryoho　36　(9)　1481-1484　2009

  1968. EUS-FNAで診断し得た後腹膜平滑筋肉腫の一例

    菅野敦, 佐藤賢一, 正宗淳, 廣田衛久, 朝倉徹, 下瀬川徹, 元井冬彦, 江川新一, 海野倫明, 石田和之

    東北医学雑誌　121　(2)　204-204　2009

    Publisher: 東北医学会

    ISSN： 0040-8700

  1969. 【創薬研究者必見!最新トランスポーター研究2009】 動態における薬物トランスポーターの役割 トランスポーターと癌 (遺伝子医学MOOK)

    鈴木健弘, 海野倫明, 阿部高明

    遺伝子医学MOOK　(12)　140-143　2009/01

  1970. Optimization of glucose level to determine the stimulation index of isolated rat islets

    SAKATA Naoaki, EGAWA Shinichi, SUMI Shoichiro, UNNO Michiaki

    膵臓 = The Journal of Japan Pancreas Society　23　(6)　756-757　2008/12/25

    ISSN： 0913-0071

  1971. Surgical treatment of rare endocrine tumors

    S. Egawa, M. Sunamura, S. Matsuno, M. Unno

    Diseases of the Pancreas: Current Surgical Therapy　735-747　2008/12/01

    DOI： 10.1007/978-3-540-28656-1_71 　

  1972. 【低侵襲を目指した膵領域の腹腔鏡下手術】 腹腔鏡下膵仮性嚢胞消化管吻合術 (胆と膵)

    福山尚治, 武田和憲, 江川新一, 徳村弘実, 海野倫明

    胆と膵　29　(12)　1361-1364　2008/12

  1973. KNOCKDOWN OF S100A4 CAUSES SUPPRESSION OF CELL GROWTH AND MOTILITY IN PANCREATIC CANCER CELLS

    N. Tsukamoto, T. Tabata, Z. Gu, S. Yokoyama, N. Kaneko, T. Furukawa, M. Sunamura, M. Ishida, H. Abe, H. Hayashi, S. Egawa, M. Unno, A. Horii

    PANCREAS　37　(4)　498-499　2008/11

    ISSN： 0885-3177

  1974. 【先天性胆道拡張症 その発生から長期予後まで】 成人の先天性胆道拡張症術後長期成績からみた肝内結石 (胆と膵)

    大塚英郎, 吉田寛, 元井冬彦, 片寄友, 力山敏樹, 江川新一, 海野倫明

    胆と膵　29　(10)　921-925　2008/10

  1975. Institutional indications for islet transplantation after total pancreatectomy

    SAKATA NAOAKI, EGAWA SHINICHI, MOTOI FUYUHIKO, MIKAMI YUKIO, ISHIDA MASAHARU, AOKI TAKESHI, OTTOMO SHIGERU, FUKUYAMA SHOJI, RIKIYAMA TOSHIKI, KATAYOSE YU, GOTO MASAFUMI, UNNO MICHIAKI

    J Hepatobiliary Pancreat Surg　15　(5)　488-492　2008/09/01

    ISSN： 1436-0691

  1976. Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maljunction and congenital biliary cystic disease

    NAKAMURA HIROYUKI, KATAYOSE YU, RIKIYAMA TOSHIKI, ONOGAWA TOHRU, YAMAMOTO KUNIHARU, YOSHIDA HIROSHI, HAYASHI HIROKI, OHTSUKA HIDEO, HAYASHI YUTAKA, EGAWA SHIN-ICHI, UNNO MICHIAKI

    J Hepatobiliary Pancreat Surg　15　(5)　554-559　2008/09/01

    ISSN： 1436-0691

  1977. 基礎研究の新たな方向性を解く 疾患解明Overview 膵癌のシグナル伝達経路と標的分子 (実験医学)

    江川新一, 海野倫明

    実験医学　26　(14)　2273-2279　2008/09

  1978. 【肝内胆管癌の病態特性からみた外科治療の適応と限界】 腫瘤形成型肝内胆管癌の手術適応 (消化器科)

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 有明恭平, 江川新一, 海野倫明

    消化器科　47　(3)　284-289　2008/09

  1979. 【肝胆膵手術 術中トラブル回避法・対処法 こんなときどうする】 膵臓手術 門脈・脾動脈・脾静脈出血 回避と対処 (手術)

    阿部永, 元井冬彦, 乙供茂, 赤田昌紀, 江川新一, 海野倫明

    手術　62　(9)　1265-1270　2008/08

    Publisher: 金原出版

    ISSN： 0037-4423

  1980. O-2-312 Type4胃癌症例の検討(胃 転移,一般演題(口演),第63回日本消化器外科学会総会)

    山村 明寛, 三浦 康, 柴田 近, 木内 誠, 鹿郷 昌之, 上野 達也, 唐澤 秀明, 金子 直征, 海野 倫明, 佐々木 巌

    日本消化器外科学会雑誌　41　(7)　1247-1247　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1981. WS-5-5 肝門部胆管癌の外科切除成績と新規治療戦略 : 断端陰性化を目指して(ワークショップ5 肛門部胆管癌の治療戦略 : 切除断端と剥離面の陰性化を目的とした術式の工夫と限界点,第63回日本消化器外科学会総会)

    力山 敏樹, 片寄 友, 元井 冬彦, 山本 久仁治, 小野川 徹, 吉田 寛, 林 洋毅, 森川 孝則, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　41　(7)　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1982. RS-88 肝門部胆管癌肝切除症例のSSI対策 : 周術期免疫増強栄養剤(IED)の有効性比較試験(要望演題4-6 消化器外科とSSI対策6,第63回日本消化器外科学会総会)

    吉田 寛, 片寄 友, 力山 敏樹, 福山 尚治, 元井 冬彦, 小野川 徹, 山本 久仁治, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　41　(7)　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1983. RS-181 ジェムシタビンによる胆道癌術後補助化学療法の現状(要望演題9-3 消化器癌補助化学療法 肝・胆・膵,第63回日本消化器外科学会総会)

    大塚 英郎, 片寄 友, 江川 新一, 力山 敏樹, 福山 尚治, 元井 冬彦, 小野川 徹, 山本 久仁治, 吉田 寛, 海野 倫明

    日本消化器外科学会雑誌　41　(7)　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1984. RS-242 当科切除不能進行膵癌に対する治療成績(要望演題12-3 浸潤性膵管癌の長期生存例,短期再発例の特徴3,第63回日本消化器外科学会総会)

    乙供 茂, 江川 新一, 片寄 友, 力山 敏樹, 福山 尚治, 元井 冬彦, 山本 久仁治, 吉田 寛, 海野 倫明

    日本消化器外科学会雑誌　41　(7)　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1985. O-1-103 膵臓癌におけるIGF-2の転写異常(胆・膵 研究4,一般演題(口演),第63回日本消化器外科学会総会)

    阿部 永, B aojin Fu, Migde Luo, Michael Goggins, 江川 新一, 海野 倫明, Christine Donahue

    日本消化器外科学会雑誌　41　(7)　2008/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  1986. 【肝内胆管癌 2008,up-to-date】 放射線化学および補助療法の進歩 肝内胆管癌に対する放射線療法の治療成績 (肝・胆・膵)

    吉田寛, 片寄友, 力山敏樹, 元井冬彦, 江川新一, 海野倫明

    肝・胆・膵　57　(1)　143-147　2008/07

  1987. 【縫合・吻合手技 安全・確実な技術を習得するために】 肝胆膵 膵頭十二指腸切除術の再建 吻合法を中心に (消化器外科)

    江川新一, 元井冬彦, 乙供茂, 阿部永, 岡田恭穂, 力山敏樹, 片寄友, 海野倫明

    消化器外科　31　(8)　1255-1261　2008/07

  1988. Assessment of an ideal glucose level for stimulation index

    Naoaki Sakata, Shinichi Egawa, Shoichiro Sumi, Eba Hathout, Michiaki Unno

    DIABETES　57　A731-A731　2008/06

    ISSN： 0012-1797

  1989. 【みてわかる消化器外科主要手術12と必須看護リストアップ】 みてわかる総胆管切開術 (消化器外科Nursing)

    大塚英郎, 海野倫明

    消化器外科Nursing　13　(6)　574-579　2008/06

  1990. 【肝細胞癌の治療戦略】 肝細胞癌の治療戦略 (消化器外科)

    海野倫明

    消化器外科　31　(6)　941-943　2008/05

  1991. Comparison of quality of life (QOL) between ileal J pouch-anal anastomosis and permanent ileostomy after proctocolectomy for ulcerative colitis in elderly patients

    Munenori Nagao, Kouhei Fukushima, Chikashi Shibata, Koh Miura, Hitoshi Ogawa, Yuji Funayama, Michiaki Unno, Iwao Sasaki

    GASTROENTEROLOGY　134　(4)　A864-A864　2008/04

    ISSN： 0016-5085

  1992. 【知っておくべきPoor Risk患者の周術期管理】 糖尿病患者の周術期管理 (外科治療)

    吉田寛, 元井冬彦, 片寄友, 力山敏樹, 江川新一, 海野倫明

    外科治療　98　(4)　362-366　2008/04

    Publisher: 永井書店

    ISSN： 0433-2644

  1993. ヒト薬物トランスポータータンパク質の定量的発現プロファイルによる培養膵臓癌細胞のgemcitabine薬剤耐性候補因子の同定

    大峰健, 川口桂, 岩瀬怜, 上家潤一, 勝倉由樹, 小野川徹, 江川新一, 海野倫明, 大槻純男, 寺崎哲也

    日本薬学会年会要旨集　128th　(4)　142　2008/03/05

    ISSN： 0918-9823

  1994. An experience of the successful treatment for repeated hemorrhage from arterial stump after pancreaticoduodenectomy

    Kei Kawaguchi, Shinichi Egawa, Naoaki Sakata, Takaho Okada, Fuyuhiko Motoi, Shoji Fukuyama, Toshiki Rikiyama, Yu Katayose, Michiaki Unno

    PANCREAS　36　(2)　220-221　2008/03

    ISSN： 0885-3177

  1995. Pacritaxel as a second-line chemotherapy after failure of gemcitabine

    Shinichi Egawa, Fuyuhiko Motoi, Shinpei Maeda, Yo Kitamura, Kyouhei Ariake, Kei Kawaguchi, Hidekazu Tsukamoto, Satoru Yokoyama, Takeshi Aoki, Shigeru Ottomo, Naoaki Sakata, Takaho Okada, Shoji Fukuyama, Toshiki Rikiyama, Yu Katayose, Michiaki Unno

    PANCREAS　36　(2)　222-222　2008/03

    ISSN： 0885-3177

  1996. 【急性膵炎の診療update 外科的治療】 腹腔鏡下膵仮性嚢胞消化管吻合術 (医薬の門)

    福山尚治, 三上幸夫, 江川新一, 海野倫明, 武田和憲

    医薬の門　48　(1)　72-75　2008/02

  1997. Characteristic clinicopathological phenotypes of the types of intraductal papillary-mucinous neoplasm of the pancreas: A Japanese multi-institutional study

    T. Furukawa, T. Hatori, A. Yamamoto, N. Ohike, T. Morohoshi, S. Ban, M. Shimizu, S. Egawa, M. Unno, S. Takao, A. Osako, S. Yonezawa

    LABORATORY INVESTIGATION　88　304A-304A　2008/01

    ISSN： 0023-6837

  1998. Reduced ß cell proliferation and impaired glucose tolerance in pancreatic ß cell specific Extl3 knockout mice.

    Takahashi, I, Nata, K, Noguchi, N, Ikeda, T, Sugihara, K, Asano, M, Yoshikawa, T, Yamauchi, A, Shervani, N. J, Uruno, A, Unno, M, Takasawa, S, Okamoto, H, Sugawara, A

    Diabetologia　51　S307　2008

  1999. 当施設における腹腔鏡下膵体尾部切除術の経験

    福山尚治, 江川新一, 鹿郷昌之, 力山敏樹, 片寄友, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　188　2008

  2000. 厳密な血糖管理による肝胆膵外科周術期合併症予防の可能性

    大塚英郎, 吉田寛, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 林洋毅, 森川孝則, 岡田恭穂, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　197　2008

  2001. 進行肝門部胆管癌におけるMDCT‐DICOMデータに基づいた術前照射計画と仮想肝切除シミュレーション

    小野川徹, 力山敏樹, 片寄友, 山本久仁治, 吉田寛, 林洋毅, 森川孝則, 大塚英郎, 福山尚治, 元井冬彦, 岡田恭穂, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　148　2008

  2002. 診断に苦慮したFNHの一例

    前田晋平, 山本久仁治, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 吉田寛, 小野川徹, 林洋毅, 岡田恭穂, 森川孝則, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　374　2008

  2003. 肝拡大右葉切除術後に膵頭十二指腸切除術を施行した膵管内管状腺癌の1例

    森川孝則, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁冶, 吉田寛, 岡田恭穂, 林洋毅, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　341　2008

  2004. 残膵再発を来たした膵管内乳頭腺癌の1例

    川口桂, 元井冬彦, 坂田直昭, 岡田恭穂, 林洋毅, 小野川徹, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　352　2008

  2005. #16リンパ節転移が認められた巨大肝内胆管癌長期生存の1例

    有明恭平, 大塚英朗, 乙供茂, 岡田恭穂, 林洋毅, 森川孝則, 小野川徹, 山本久仁治, 吉田寛, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　311　2008

  2006. 術前診断が困難であった膵腺房細胞癌の一例

    北村洋, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 岡田恭穂, 森川孝則, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　367　2008

  2007. 悪性膵内分泌腫瘍に対する治療

    青木豪, 元井冬彦, 乙供茂, 森川孝則, 岡田恭穂, 吉田寛, 小野川徹, 山本久仁治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　257　2008

  2008. 塩酸ゲムシタビン(GEM)単剤による膵癌術前化学療法(NAC)の意義

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　198　2008

  2009. 肝門部胆管癌の術前放射線化学療法:Pilot studyからの知見と第I相試験

    片寄友, 小野川徹, 岡上能斗竜, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 吉田寛, 林洋毅, 森川孝則, 岡田恭穂, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　214　2008

  2010. 膵癌での分子標的治療に向けたS100A4を中心としたがん関連遺伝子の解析

    塚本信和, 田畑孝洋, 石田晶玄, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明, 堀井明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　247　2008

  2011. T2以深胆嚢癌における肝切除・胆管切除・膵頭十二指腸切除・他臓器合併切除の意義

    林洋毅, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 吉田寛, 小野川徹, 森川孝則, 岡田恭穂, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　138　2008

  2012. 膵癌細胞株のゲムシタビン感受性と,網羅的タンパク同時絶対定量解析に基づくトランスポーター発現プロファイルの解明

    川口桂, 元井久彦, 有明恭平, 横山智, 大塚英郎, 力山敏樹, 片寄友, 江川新一, 海野倫明, 大峰健, 大槻純男, 寺崎哲也

    胆汁酸研究会プログラム・抄録集　30th　22　2008

  2013. 肝門部胆管癌肝切除術後における新鮮凍結血漿使用法の検討

    森川孝則, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 山本久仁治, 吉田寛, 岡田恭穂, 林洋毅, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　250　2008

  2014. 膵癌術後の塩酸Gemcitabine投与中に致死的な薬剤性肝障害を生じた一例

    岡田恭穂, 元井冬彦, 山本久仁治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　237　2008

  2015. 肝門部胆管癌における門脈分岐変異時の胆管形態と術式選択

    力山敏樹, 北見昌広, 片寄友, 福山尚治, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 森川孝則, 岡田恭穂, 大塚英郎, 乙供茂, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　116　2008

  2016. 当科で経験した膵腺房細胞癌(pancreatic acinar cell carcinoma)3切除例の検討

    横山智, 元井冬彦, 川口桂, 青木豪, 大塚英郎, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　344　2008

  2017. 当科5年間における膵頭十二指腸切除術術後膵液瘻の検討

    乙供茂, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 吉田寛, 小野川徹, 林洋毅, 岡田恭穂, 森川孝則, 大塚英郎, 江川新一, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　204　2008

  2018. 慢性膵炎仮性嚢胞内出血

    江川新一, 佐藤学, 原田昭彦, 蝦名宣男, 福山尚治, 元井冬彦, 海野倫明

    日本肝胆膵外科学会・学術集会プログラム・抄録集　20th　376　2008

  2019. 急性膵炎の理解 (ナーシングプロセス 急性膵炎患者の看護)

    乙供 茂, 江川 新一, 海野 倫明

    クリニカルスタディ　28　(14)　1323-1329　2007/12

    Publisher: メヂカルフレンド社

    ISSN： 0388-5585

  2020. 急性膵炎患者の看護 急性膵炎の理解 (クリニカルスタディ)

    乙供茂, 江川新一, 海野倫明

    クリニカルスタディ　28　(14)　55-61　2007/12

  2021. 【肝胆膵がんと化学療法のすべて】 胆道疾患 病期による化学療法の選択 胆管癌に対するNeoadjuvant chemotherapy(chemoradiationを含む)の試み (肝・胆・膵)

    片寄友, 江川新一, 海野倫明

    肝・胆・膵　55　(5)　969-977　2007/11

  2022. Hyperglycemia and diabetic renal change in a model of polyvinyl alcohol bioartificial pancreas transplantation

    SAKATA Naoaki, SUMI Shoichiro, GU Yuanjun, QI Meirigeng, YAMAMOTO Chiduru, SUNAMURA Makoto, EGAWA Shinichi, UNNO Michiaki, MATSUNO Seiki, INOUE Kazutomo

    Suizo　22　(5)　602-603　2007/10/25

    Publisher: Japan Pancreas Society

    DOI： 10.2958/suizo.22.602 　

    ISSN： 0913-0071

  2023. S5-2. 術前化学療法後に切除した高度進行胃癌症例の検討(第36回胃外科・術後障害研究会)

    木内 誠, 溝井 賢幸, 柴田 近, 小林 照忠, 上野 達也, 海野 倫明, 佐々木 巌

    日本消化器外科学会雑誌　40　(10)　1751-1751　2007/10/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2024. An unknown primary cancer with multiple abdominal metastases finally immunohistochemically diagnosed to be lung carcinoma

    Koh Miura, Mika Watanabe, Terutada Kobayashi, Takayuki Yamada, Yuji Funayama, Kouhei Fukushima, Tadayuki Okumoto, Shunsuke Kato, Makoto Kinouchi, Chikashi Shibata, Shinobu Ohnuma, Hiroyuki Sasaki, Ken-Ichi Shiiba, Michiaki Unno, Iwao Sasaki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A149-A149　2007/10

    ISSN： 0815-9319

  2025. Granulocyte-colony stimulating factor producing pancreatic cancer: report of a case

    Kazuhiro Takami, Koh Miura, Shin-Ichi Egawa, Takuya Moriya, Hideaki Karasawa, Michiaki Unno, Iwao Sasaki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A249-A249　2007/10

    ISSN： 0815-9319

  2026. The experience of laparoscopic distal pancreatectomy

    Shoji Fukuyama, Shinichi Egawa, Takahiro Kamiga, Naoaki Sakata, Hiroki Hayashi, Toru Onogawa, Hiroshi Yoshida, Kuniharu Yamamoto, Yukio Mikami, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A248-A248　2007/10

    ISSN： 0815-9319

  2027. Preoparative chemoradiation therapy for advanced cholangiocarcinoma

    Tohru Onogawa, Yu Katayose, Toshiki Rikiyama, Kuniharu Yamamoto, Hiroshi Yoshida, Hiroki Hayashi, Hideo Ohtsuka, Shinichi Egawa, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A257-A257　2007/10

    ISSN： 0815-9319

  2028. Long-term survivor of anorectal melanoma after abdominoperineal resection, two metastasectomies, and radiosurgical therapies: report of a case

    Shinobu Ohnuma, Koh Miura, Terutada Kobayashi, Yuji Funayama, Kouhei Fukushima, Chikashi Shibata, Hitoshi Ogawa, Tatsuya Ueno, Masayuki Kakyo, Makoto Kinouchi, Atsushi Oyama, Munenori Nagao, Hiroyuki Sasaki, Kazuhiro Takami, Naoyuki Kaneko, Hideaki Karasawa, Ken-Ichi Shiiba, Takayuki Mizoi, Michiaki Unno, Iwao Sasaki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A204-A204　2007/10

    ISSN： 0815-9319

  2029. A case of IgG4-related sclerosing cholangitis that mimics infi ltrating hilar cholangiocarcinoma

    Mitsuhisa Mutoh, Yu Katayose, Toshiki Rikiyama, Toru Onogawa, Kuniharu Yamamoto, Hiroshi Yoshida, Hiroki Hayashi, Hiroo Naitoh, Shinichi Egawa, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A165-A165　2007/10

    ISSN： 0815-9319

  2030. Preoperative intraluminal brachytherapy for hilar cholangiocarcinoma: perioperative safety and benefits

    Adoru Okaue, Yu Katayose, Toshiki Rikiyama, Kuniharu Yamamoto, Hiroshi Yoshida, Tohru Onogawa, Hiroki Hayashi, Shinichi Egawa, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A221-A221　2007/10

    ISSN： 0815-9319

  2031. A case report of invasive carcinoma derived sequentially from mucin-producing bile duct tumor

    Hiroyuki Nakamura, Yu Katayose, Toshiki Rikiyama, Toru Onogawa, Kuniharu Yamamoto, Hiroshi Yoshida, Hiroki Hayashi, Hideo Otsuka, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A206-A206　2007/10

    ISSN： 0815-9319

  2032. Two resected cases of advanced gallbladder cancer after neoadjuvant chemotherapy

    Hiroki Hayashi, Yu Kayayose, Toshiki Rikiyama, Kuniharu Yamamoto, Toru Onogawa, Hiroshi Yoshida, Hideo Ohtsuka, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A256-A256　2007/10

    ISSN： 0815-9319

  2033. Number of lymph nodes metastases and its impact on prognosis of hilar cholangioarcinoma

    Yu Katayose, Toshiki Rikiyama, Toru Onogawa, Kuniharu Yamamoto, Hiroshi Yosida, Hiroki Hayashi, Shinichi Egawa, Michiaki Unno

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　22　A256-A256　2007/10

    ISSN： 0815-9319

  2034. 膵臓外科領域疾患の膵島移植適応について―膵全摘ならびに膵亜全摘症例の検討―

    坂田直昭, 江川新一, 元井冬彦, 三上幸夫, 神賀貴大, 岡田恭穂, 福山尚治, 後藤昌史, 海野倫明

    移植　42　236　2007/10

    ISSN： 0578-7947

  2035. 腹腔鏡下胆嚢摘出術（ラパコレ）後に見つかった胆嚢癌にどう対処するか？ (臨床に直結する肝・胆・膵疾患治療のエビデンス)

    林 洋毅, 海野 倫明

    臨床に直結する肝・胆・膵疾患治療のエビデンス　206-208　2007/10

  2036. 転移性インスリノーマに対する集学的治療

    青木豪, 元井冬彦, 吉田寛, 山本久仁治, 小野川徹, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　42　(2)　815　2007/09/20

    ISSN： 0021-4671

  2037. 腫瘍マーカー(TM)は,切除後補助化学療法の効果予測指標となりうるか?

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    日本癌治療学会誌　42　(2)　817　2007/09/20

    ISSN： 0021-4671

  2038. 胆道癌に対する治療戦略―術前化学放射線療法の意義と安全性―

    片寄友, 小野川徹, 岡上能斗竜, 林洋毅, 力山敏樹, 山本久仁治, 吉田寛, 大塚英郎, 江川新一, 海野倫明

    日本癌治療学会誌　42　(2)　322　2007/09/20

    ISSN： 0021-4671

  2039. 胆道癌に対する補助療法―外来抗癌剤の安全性とコンプライアンス

    片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 大塚英郎, 江川新一, 海野倫明

    胆道　21　(3)　337　2007/08/31

    ISSN： 0914-0077

  2040. T2以深胆嚢癌に対する肝切除・肝外胆管切除・膵頭十二指腸切除の意義

    林洋毅, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 岡田恭穂, 神賀貴大, 大塚英郎, 江川新一, 海野倫明

    胆道　21　(3)　319　2007/08/31

    ISSN： 0914-0077

  2041. 胆道癌の術前診断におけるFDG‐PETの新たな価値~間質浸潤診断について

    山本久仁治, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 小野川徹, 吉田寛, 林洋毅, 岡田恭穂, 神賀貴大, 大塚英郎, 江川新一, 海野倫明

    胆道　21　(3)　384　2007/08/31

    ISSN： 0914-0077

  2042. 胆管内乳頭状腫瘍の臨床病理学的検討~膵IPMNとの比較

    岡上能斗竜, 片寄友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 岡田恭穂, 林洋毅, 神賀貴大, 坂田直昭, 大塚英郎, 江川新一, 海野倫明

    胆道　21　(3)　344　2007/08/31

    ISSN： 0914-0077

  2043. P-1-245 食道浸潤胃癌の臨床病理学的検討(胃癌 進行1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    木内 誠, 柴田 近, 三浦 康, 小林 照忠, 上野 達也, 小山 淳, 福島 浩平, 舟山 裕士, 海野 倫明, 佐々木 巌

    日本消化器外科学会雑誌　40　(7)　1271-1271　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2044. P-2-742 急激な経過をたどった骨盤内anaplastic large cell lymphomaの1例(免疫系,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    高見 一弘, 三浦 康, 溝井 賢幸, 小林 照忠, 木内 誠, 小山 淳, 大沼 忍, 佐々木 宏之, 海野 倫明, 佐々木 巌

    日本消化器外科学会雑誌　40　(7)　1431-1431　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2045. A case of acute abdomen due to rupture of mucinous cystadenoma of the pancreas

    Masaharu Ishida, Shinichi Egawa, Yukio Mikami, Fuyuhiko Motoi, Tadayoshi Abe, Shoji Fukuyama, Ryoichi Anzai, Hiroaki Tanno, Makoto Sunamura, Tom Furukawa, Michiaki Unno

    PANCREAS　35　(1)　89-89　2007/07

    ISSN： 0885-3177

  2046. PD-7-7 胆管癌に対する拡大手術の適応と限界 : 治療成績向上のためには?(パネルディスカッション7 胆嚢,胆管癌に対する拡大手術の適応と限界,第62回日本消化器外科学会定期学術総会)

    力山 敏樹, 片寄 友, 元井 冬彦, 山本 久仁治, 小野川 徹, 吉田 寛, 林 洋毅, 福山 尚治, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2047. P-1-510 大腸癌細胞同所移植自然転移モデルを用いた転移能と遺伝子発現プロファイルの解析(続報)(大腸・肛門 基礎1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    佐々木 宏之, 三浦 康, 小林 照忠, 木内 誠, 小山 淳, 舟山 裕士, 海野 倫明, 佐々木 巌, 藤渕 航

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2048. P-1-419 膵島移植に対する膵全摘ならびに亜全摘症例の検討(膵 手術・他,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    坂田 直昭, 元井 冬彦, 三上 幸夫, 福山 尚治, 力山 敏樹, 片寄 友, 江川 新一, 後藤 昌史, 岡 芳知, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2049. P-1-686 当科における硬化性胆管炎手術例の検討(胆 良性4,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    岡上 能斗竜, 片寄 友, 力山 敏樹, 山本 久仁治, 小野川 徹, 吉田 寛, 林 洋毅, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2050. P-2-81 脾疾患に対する腹腔鏡手術の優位性の検討(脾・門脈 脾臓,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    福山 尚治, 江川 新一, 神賀 貴大, 坂田 直昭, 三上 幸夫, 元井 冬彦, 力山 敏樹, 片寄 友, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2051. P-2-422 膵indeterminate mucin-producing cystic neoplasmと考えられた粘液産生膵腫瘍の2例(膵 膵管内腫瘍1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    石田 晶玄, 江川 新一, 元井 冬彦, 福山 尚治, 力山 敏樹, 片寄 友, 森谷 卓也, 古川 徹, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2052. P-2-424 石灰化慢性膵炎に合併した膵管内乳頭粘液性腫瘍(IPMN)症例の検討(膵 膵管内腫瘍1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    青木 豪, 江川 新一, 元井 冬彦, 福山 尚治, 力山 敏樹, 片寄 友, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2053. P-2-665 ダウン症候群に合併した膵管胆道合流異常症と胆嚢癌の1例(胆 症例 悪性腫瘍1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)

    神賀 貴大, 丹野 弘晃, 安西 良一, 赤田 昌紀, 江川 新一, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　2007/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2054. 膵indeterminate mucin-producing cystic neoplasmと考えられた粘液産生膵腫瘍の2例

    石田 晶玄, 江川 新一, 元井 冬彦, 福山 尚治, 力山 敏樹, 片寄 友, 森谷 卓也, 古川 徹, 海野 倫明

    日本消化器外科学会雑誌　40　(7)　1391-1391　2007/07

    Publisher: (一社)日本消化器外科学会

    ISSN： 0386-9768

  2055. Staging of pancreatic endocrine tumors in Japan

    Shinichi Egawa, Masao Tanaka, Kazururo Mizumoto, Hiroki Toma, Takeshi Aoki, Takahiro Kamiga, Naoaki Sakata, Yukio Mikami, Fuyuhiko Motoi, Shoji Fukuyama, Chikashi Shibata, Iwao Sasaki, Michiaki Unno

    GASTROENTEROLOGY　132　(4)　A870-A870　2007/04

    ISSN： 0016-5085

  2056. 膵管内乳頭粘液腫瘍切除例の長期予後と再発例 (日本消化器病学会雑誌)

    元井冬彦, 江川新一, 海野倫明

    日本消化器病学会雑誌　104　(臨増総会)　A234-A234　2007/03

  2057. Study on the visualization of carrier-mediated transport

    Masahiro Okada, Hiroaki Yamaguchi, Minako Kobayashi, Toshiko Takeuchi, Masayuki Tanemoto, Michiaki Unno, Takaaki Abe, Takanori Hishinuma, Junichi Goto, Nariyasu Mano

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　127　181-182　2007

    ISSN： 0031-6903

  2058. Embryonic lethality and impaired beta cell replication by disruption of Reg receptor gene.

    Takasawa, S, Nata, K, Takahashi, I, Ikeda, T, Noguchi, N, Asano, M, Sugihara, K, Yamauchi, A, Yoshikawa, T, Shervani, N.J, Uruno, A, Unno, M, Sugawara, A, Okamoto, H

    Diabetologia　50　(Suppl. 1)　S206　2007

  2059. Impaired beta-cell replication in heterozygous mutant mice of Reg receptor gene.

    Takasawa, S, Nata, K, Takahashi, I, Ikeda, T, Noguchi, N, Yamauchi, A, Yoshikawa, T, Shervani, N.J, Sugihara, K, Asano, M, Unno, M, Sugawara, A, Okamoto, H

    Diabetes　56　(Suppl. 1)　1643-P　2007

  2060. 当科で経験した膵全摘症例の膵島移植適応に関する検討

    坂田直昭, 元井冬彦, 三上幸夫, 神賀貴大, 福山尚治, 江川新一, 後藤昌史, 岡芳知, 海野倫明

    移植　42　(3)　292-292　2007

  2061. Reoperations after frey procedure for chronic pancreatitis

    S. Egawa, N. Sakata, Y. Mikami, F. Motoi, T. Abe, S. Fukuyama, M. Unno

    PANCREAS　33　(4)　458-458　2006/11

    ISSN： 0885-3177

  2062. Intracellular signaling in Reg-induced pancreatic beta cell regeneration: involvement of the PI(3)K/ATF-2/cyclin D1 signaling pathway in the Reg/Reg receptor system

    S. Takasawa, K. Nata, T. Ikeda, N. Noguchi, I. Takahashi, A. Yamauchi, T. Yoshikawa, N. J. Shervani, M. Unno, H. Okamoto

    DIABETOLOGIA　49　(Suppl. 1)　307-308　2006/09

    ISSN： 0012-186X

  2063. すい腺へん平上皮癌切除例の検討

    元井冬彦, 古川徹, 阿部忠義, 福山尚治, 江川新一, 砂村真琴, 海野倫明

    日本消化器病学会雑誌　103　A281　2006/03/20

    ISSN： 0446-6586

  2064. 難治性膵疾患に関する調査研究 1.急性膵炎 ラット重症急性膵炎における好中球に由来したGut Bacterial Translocationの検討

    砂村眞琴, 三上幸夫, 福山嘉治, 江川新一, 海野倫明

    難治性膵疾患に関する調査研究 平成17年度 総括・分担研究報告書　168-171　2006

  2065. 【膵疾患と栄養】 膵切除後の栄養評価からみた栄養法 (栄養-評価と治療)

    福山尚治, 江川新一, 砂村眞琴, 海野倫明

    栄養-評価と治療　22　(5)　547-548　2005/10

  2066. 【癌治療のプロトコール2005-2006】 胆管癌治療のプロトコール (臨床外科)

    及川昌也, 片寄友, 力山敏樹, 山本久仁治, 林洋毅, 海野倫明

    臨床外科　60　(11)　167-172　2005/10

    DOI： 10.11477/mf.1407100220 　

  2067. 【再手術 予防・適応・手術手技】 術後胆管狭窄 (手術)

    山本久仁治, 片寄友, 力山敏樹, 及川昌也, 林洋毅, 海野倫明

    手術　59　(10)　1507-1511　2005/09

    Publisher: 金原出版

    ISSN： 0037-4423

  2068. 【最新 胆嚢癌手術】 拡大胆嚢摘出術 定型的手術と非定型手術 (手術)

    海野倫明

    手術　59　(9)　1247-1251　2005/08

  2069. 大腸癌肝転移に対する外科的治療戦略(肝臓16, 第60回日本消化器外科学会総会)

    山本 久仁治, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 小野川 徹, 武藤 満完, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1051-1051　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2070. 当科における膵管胆道合流異常症例に対する外科手術成績(胆道2, 第60回日本消化器外科学会総会)

    中村 啓之, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1009-1009　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2071. 進行肝門部胆管癌における門脈合併切除再建の治療成績と意義(膵胆道癌における血管合併切除の意義-適応と限界, 第60回日本消化器外科学会総会)

    力山 敏樹, 海野 倫明, 片寄 友, 及川 昌也, 山本 久仁治, 小野川 徹, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　945-945　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2072. 肝門部胆管癌術後感染症の検討(肝・胆・膵43, 第60回日本消化器外科学会総会)

    武藤 満完, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1229-1229　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2073. 胆管細胞癌の予後因子に関する検討-腫瘍造影効果の点から(胆道9, 第60回日本消化器外科学会総会)

    及川 昌也, 海野 倫明, 片寄 友, 力山 敏樹, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1024-1024　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2074. IgG4-関連自己免疫性膵炎に合併した肝炎症性偽腫瘍の1例(肝・胆・膵30, 第60回日本消化器外科学会総会)

    深瀬 耕二, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁冶, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1201-1201　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2075. T2胆嚢癌に対する外科治療方針 : 基本術式および縮小手術の可能性について(胆嚢癌に対する切除術式の選択とその根拠, 第60回日本消化器外科学会総会)

    海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　970-970　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2076. 肝拡大葉切除術後にMRSA関連糸球体腎炎を併発した3症例(第60回日本消化器外科学会定期学術総会)

    小田 聡, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　38　(7)　1134-1134　2005/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2077. Expression of the organic cation transporter SLC22A16 can be a feature of human epithelial ovarian cancers with different histological type.

    K Ota, JI Akahira, N Sato, T Moriya, M Unno, T Abe, K Ito, N Yaegashi

    JOURNAL OF CLINICAL ONCOLOGY　23　(16)　486S-486S　2005/06

    ISSN： 0732-183X

    eISSN： 1527-7755

  2078. 【化学放射線療法 現状とイメージングによる効果判定】 胆管癌に対する化学放射線療法 (臨床外科)

    片寄友, 海野倫明, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 松野正紀

    臨床外科　60　(6)　751-756　2005/06

    DOI： 10.11477/mf.1407100113 　

  2079. 【胆道疾患の臨床 最近の進歩】 胆道癌 胆嚢癌の手術と遠隔成績 (臨床消化器内科)

    海野倫明, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 松野正紀

    臨床消化器内科　20　(7)　1025-1030　2005/05

  2080. 進行肝門部胆管癌に対する門脈合併切除再建の意義と手技(第105回日本外科学会定期学術集会)

    力山 敏樹, 海野 倫明, 片寄 友, 及川 昌也, 山本 久仁治, 小野川 徹, 松野 正紀

    日本外科学会雑誌　106　295-295　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2081. 当科における先天性胆道拡張症 : 術後長期経過観察症例の検討(第105回日本外科学会定期学術集会)

    中村 啓之, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本外科学会雑誌　106　354-354　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2082. 肝門部胆管癌肝切除における術後感染症の現状(第105回日本外科学会定期学術集会)

    武藤 満完, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 小野川 徹, 松野 正紀

    日本外科学会雑誌　106　598-598　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2083. 高度進行肝門部胆管癌に対する192Ir-RALS腔内照射+体外照射+化学療法の治療意義(第105回日本外科学会定期学術集会)

    片寄 友, 海野 倫明, 力山 敏樹, 及川 昌也, 山本 久仁治, 小野川 徹, 阿部 友哉, 大塩 博, 松野 正紀

    日本外科学会雑誌　106　602-602　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2084. 大腸癌でのLST-2発現(第105回日本外科学会定期学術集会)

    井伊 貴幸, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 小野川 徹, 大塩 博, 深瀬 耕二, 武藤 満完

    日本外科学会雑誌　106　620-620　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2085. 胆汁酸輸送によりPPARα, FXR, CREB転写因子複合体がCOX-2転写誘導を活性化する(第105回日本外科学会定期学術集会)

    大塩 博, 海野 倫明, 小野川 徹, 大塚 英郎, 佐藤 武揚, 井伊 貴幸, 武藤 満完, 松野 正紀

    日本外科学会雑誌　106　221-221　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2086. ss以深胆嚢癌の治療方針 : 積極的に手術すべき症例と縮小手術すべき症例の選択(第105回日本外科学会定期学術集会)

    海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本外科学会雑誌　106　137-137　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2087. 胆管癌に対するZD1839 (Iressa) の放射線感受性増強による臨床応用への研究 : p27蛋白発現機構と放射線との相乗効果(第105回日本外科学会定期学術集会)

    藪内 伸一, 片寄 友, 海野 倫明, 力山 敏樹, 及川 昌也, 山本 久仁治, 白相 悟, 水間 正道, 小田 聡, 松野 正紀

    日本外科学会雑誌　106　162-162　2005/04/05

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2088. 【肝切除術 成功の秘訣】 肝切除術後管理(術後肝不全対策を含めて) (消化器外科)

    及川昌也, 海野倫明, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 武藤満完, 松野正紀

    消化器外科　28　(4)　459-463　2005/04

  2089. 【どう使うマルチスライスCT(MDCT)】 胆道癌の描出と水平方向進展の診断 (胆と膵)

    力山敏樹, 海野倫明, 片寄友, 及川昌也, 山本久仁治, 小野川徹, 石橋忠司, 森谷卓也, 松野正紀

    胆と膵　26　(臨増)　191-197　2005/03

  2090. LST-2膜外ドメインに対するモノクローナル抗体の性状解析

    石川陽菜, 菱沼隆則, 岡田匡弘, 三日市剛, 鈴木直人, 富岡佳久, 海野倫明, 阿部高明, 後藤順一

    日本薬学会年会要旨集　125th　(2)　2005

    ISSN： 0918-9823

  2091. Functional analysis of a cation transporter OCT6: A mediator of the cellular influx of adriamycin.

    Y Okitsu, H Harigae, S Takahashi, S Abe, M Okabe, M Unno, T Abe, M Kaku, T Sasaki

    BLOOD　104　(11)　177B-177B　2004/11

    ISSN： 0006-4971

  2092. 【肝疾患における免疫療法】 上皮増殖因子受容体シグナルの抑制効果をもつ新規二重特異性抗体を用いた養子免疫療法 (消化器科)

    林洋毅, 浅野竜太郎, 海野倫明

    消化器科　39　(5)　522-530　2004/11

  2093. OP-1-126 消化器癌の進展と炎症における病態の分子生物的解析(研究2)

    大塩 博, 海野 倫明, 小野川 徹, 大塚 英郎, 佐藤 武揚, 井伊 貴幸, 深瀬 耕治, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1074-1074　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2094. VS-3-05 肝門部胆管癌における血行再建の意義(ビデオシンポジウム3 : 血管再建を要する消化器外科手術 : 肝・胆・膵)

    力山 敏樹, 海野 倫明, 片寄 友, 及川 昌也, 山本 久仁治, 小野川 徹, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　955-955　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2095. PPB-3-150 肝細胞癌に対する肝切除後10年以上の長期生存例の検討(肝臨床5)

    片寄 友, 海野 倫明, 力山 敏樹, 及川 昌也, 山本 久仁治, 小野川 徹, 阿部 友哉, 大塩 博, 藪内 伸一, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1341-1341　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2096. PPB-3-162 肝内胆管癌治癒切除不能例へのマイクロ波凝固療法(MCT)の有用性の検討(肝手術3)

    深瀬 耕二, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁冶, 水間 正道

    日本消化器外科学会雑誌　37　(7)　1343-1343　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2097. PPB-3-183 胆管浸潤を呈し肝内胆管癌との鑑別が問題となった大腸癌肝転移症例の検討(転移性肝癌3)

    中村 啓之, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1345-1345　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2098. PPB-3-166 大腸癌肝転移に対する肝切除術の評価 : 系統的肝切除の意義について(転移性肝癌1)

    山本 久仁治, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 井伊 貴幸, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1343-1343　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2099. PPB-3-190 切除不能胆管癌に対する体外照射・胆管腔内照射併用金属ステント留置(胆道ステント)

    及川 昌也, 海野 倫明, 片寄 友, 力山 敏樹, 山本 久仁治, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1346-1346　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2100. WS-9-08 薬物取込みに関与するトランスポーターLST-2の発現と抗癌剤感受性(ワークショップ9 : 分子生物・遺伝子研究の消化器癌補助療法への応用)

    海野 倫明, 小野川 徹, 阿部 高明, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1004-1004　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2101. OP-3-006 当科で経験した肝嚢胞腺癌症例の臨床病理学的検討(肝7)

    小田 聡, 海野 倫明, 片寄 友, 力山 敏樹, 及川 昌也, 山本 久仁治, 竹内 丙午, 白相 悟, 松野 正紀

    日本消化器外科学会雑誌　37　(7)　1103-1103　2004/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2102. Cyclin D1 activation through ATF-2 in reg-induced pancreatic beta-cell regeneration

    S Takasawa, T Ikeda, T Akiyama, K Nata, N Noguchi, S Kawaguchi, A Yamauchi, Takahashi, I, T Onogawa, M Unno, S Matsuno, H Okamoto

    DIABETES　53　A385-A385　2004/06

    ISSN： 0012-1797

  2103. PS-213-7 CDK inhibitor p27の新規機能としての転移抑制効果と遺伝子治療への応用

    片寄 友, 海野 倫明, 水間 正道, 白相 悟, 力山 敏樹, 小野川 徹, 山本 久仁治, 藪内 伸一, 松野 正紀

    日本外科学会雑誌　105　667-667　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2104. SF-064-4 抗癌剤を取り込むトランスポーターの発現からみた癌化学療法

    海野 倫明, 小野川 徹, 阿部 高明, 松野 正紀

    日本外科学会雑誌　105　263-263　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2105. SF-073-5 癌治療標的分子としてのp27/kip1の有用性 : p27/kip1の新規機能から検討

    水間 正道, 片寄 友, 海野 倫明, 山本 久仁治, 佐々木 剛, 白相 悟, 藪内 伸一, 力山 敏樹, 柿田 徹也, 小野川 徹, 松野 正紀

    日本外科学会雑誌　105　275-275　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2106. PS-130-1 新規胆汁酸膜貫通型レセプター(Membrenetype Bile Acid Receptor; M-BAR)の機能解析

    小野川 徹, 海野 倫明, 井伊 貴幸, 阿部 高明, 種本 雅之, 片寄 友, 力山 敏樹, 柿田 徹也, 大塚 英郎, 大塩 博, 深瀬 耕二, 松野 正紀

    日本外科学会雑誌　105　541-541　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2107. PS-087-4 Jab1結合部位を欠失したp27/kip1組み込みアデノウイルスベクターは癌細胞株に対し細胞傷害性を増強する

    白相 悟, 片寄 友, 海野 倫明, 力山 敏樹, 山本 久仁治, 佐々木 剛, 水間 正道, 薮内 伸一, 松野 正紀

    日本外科学会雑誌　105　474-474　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2108. PS-051-4 Free radical scavenger, edaravoneの肝虚血再灌流に及ぼす効果

    阿部 友哉, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 柿田 徹也, 小野川 徹, 松野 正紀

    日本外科学会雑誌　105　419-419　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2109. VS-002-2 0.75mmマルチスライスCTを用いたanimated MPR像による肝門部胆肝癌の進展度診断

    力山 敏樹, 海野 倫明, 片寄 友, 柿田 徹也, 及川 昌也, 小野川 徹, 山本 久仁治, 壺井 匡浩, 石橋 忠司, 松野 正紀

    日本外科学会雑誌　105　321-321　2004/03/15

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2110. IABP,PCPSにより術中心不全から救命しえた高齢者,高度進行胃癌の1例

    三浦 康, 薮内 伸一, 椎葉 健一, 石井 誠一, 柴田 近, 溝井 賢幸, 海野 倫明, 江島 豊, 堀之内 節, 岩渕 薫, 小田 克彦, 松野 正紀, 佐々木 巌

    日本腹部救急医学会雑誌　24　(2)　430-430　2004/02

    Publisher: (一社)日本腹部救急医学会

    ISSN： 1340-2242

  2111. 15歳女児に発症したすい管胆管合流異常・胆道拡張症に伴う進行胆管癌の1例

    和田基, 石井智浩, 吉田茂彦, 中村潤, 神山隆道, 仁尾正記, 林富, 海野倫明, 松野正紀

    Minophagen Medical Review　49　(6)　2004

    ISSN： 0388-4783

  2112. Beta-cell regeneration by Reg protein: experiments with Reg knockout and transgenic mice.

    H Okamoto, M Unno, K Nata, N Noguchi, T Akiyama, NJ Shervani, T Ikeda, S Kawaguchi, A Yamauchi, T Onogawa, S Takasawa

    DIABETOLOGIA　46　A29-A30　2003/08

    ISSN： 0012-186X

  2113. 経皮的経肝門脈枝塞栓術にて門脈内血栓が対側に進展した肝切除術

    片寄 友, 海野 倫明, 力山 敏樹, 竹内 丙午, 柿田 徹也, 白相 悟, 水間 正道, 大塚 英郎, 藪内 伸一, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　812-812　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2114. animated MPR 像による肝門部・上部胆管癌進展度診断と術式選択

    力山 敏樹, 海野 倫明, 奥本 忠之, 片寄 友, 楠田 徹, 石橋 忠, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　989-989　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2115. 大腸癌肝転移に対する治療方針

    竹内 丙午, 海野 倫明, 片寄 友, 力山 敏樹, 柿田 徹也, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　986-986　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2116. 大腸癌肝転移に対するスパイラルカテーテルを用いた肝動注化学療法

    小野川 徹, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 柿田 徹也, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　887-887　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2117. PCOOHの発生と肝切除周術期血中PCOOH動態から見た肝虚血再潅流障害の評価

    柿田 徹也, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 阿部 友哉, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　753-753　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2118. 二重特異性抗体を用いた腸管癌養子免疫療法

    林 洋毅, 浅野 竜太郎, 海野 倫明, 片寄 友, 津本 浩平, 熊谷 泉, 工藤 俊雄, 松野 正紀

    日本消化器外科学会雑誌　36　(7)　741-741　2003/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2119. The mechanism of beta-cell regeneration by reg protein: Experiments with reg knockout mouse islets

    H Okamoto, S Takasawa, T Ikeda, T Akiyama, K Nata, N Shervani, N Noguchi, S Kawaguchi, T Onogawa, M Unno, S Matsuno

    DIABETES　52　A362-A362　2003/06

    ISSN： 0012-1797

  2120. 当科における肝内結石症の病型・術式の時代変遷と治療法の検討

    小野川 徹, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　104　554-555　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2121. 肝切除例閉創時における,縫合糸による手術部位感染発生率の比較検討

    藪内 伸一, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 水間 正道, 松野 正紀

    日本外科学会雑誌　104　554-554　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2122. ヒト肝細胞における有機アニオントランスポーターLST-2の転写調節機構

    大塚 英郎, 海野 倫明, 鈴木 正徳, 片寄 友, 力山 敏樹, 竹内 丙午, 小野川 徹, 佐藤 武揚, 大塩 博, 松野 正紀, 阿部 高明

    日本外科学会雑誌　104　361-361　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2123. 胆汁酸の腸肝循環を担う有機アニオントランスポーター : OATP-Eの腸管における発現と細胞内局在

    佐藤 武揚, 海野 倫明, 小野川 徹, 大塚 英郎, 片寄 友, 竹内 丙午, 安部 高明, 松野 正紀

    日本外科学会雑誌　104　361-361　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2124. p27/kipl蛋白安定化を制御した遺伝子治療の開発

    白相 悟, 片寄 友, 海野 倫明, 佐々木 剛, 水間 正道, 力山 敏樹, 竹内 丙午, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　104　287-288　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2125. 胆汁酸によるcyclooxygenase-2の誘導と胆汁酸トランスポーターの役割

    大塩 博, 海野 倫明, 小野川 徹, 大塚 英郎, 佐藤 武掲, 鈴木 正徳, 松野 正紀, 阿部 高明

    日本外科学会雑誌　104　395-395　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2126. 癌細胞における有機アニオントランスポーターLST1・LST-2強制発現によるMTX感受性増強効果の検討

    安藤 敏典, 海野 倫明, 溝井 賢幸, 椎葉 健一, 松野 正紀, 佐々木 巌

    日本外科学会雑誌　104　451-451　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2127. 変異型p27kipl組み込みアデノウイルスベクターを用いた乳癌の遺伝子治療への展望

    佐々木 剛, 片寄 友, 鈴木 正徳, 山本 久仁治, 水間 正道, 白相 悟, 海野 倫明, 力山 敏樹, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　104　451-451　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2128. 当科における胆管癌切除例の検討

    阿部 友哉, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　104　687-687　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2129. Kupffer細胞は酸化ストレスを介し肝切除後肝再生を抑制している

    森川 孝則, 竹内 丙午, 海野 倫明, 片寄 友, 力山 敏樹, 阿部 友哉, 松野 正紀

    日本外科学会雑誌　104　493-493　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2130. 各種条件下肝切離における組織障害〜透過電顕を用いた超微形態像からの検討

    鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　104　500-500　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2131. 抗上皮増殖因子受容体(EGFR)×抗CD3二重特異性抗体(diabody)を用いた胆管養子免疫療法の検討

    林 洋毅, 浅野 竜太郎, 海野 倫明, 津本 浩平, 片寄 友, 竹内 丙午, 竹村 真一, 吉田 寛, 真壁 幸樹, 西村 幸浩, 久保田 麗夫, 鈴木 正徳, 工藤 俊雄, 熊谷 泉, 松野 正紀

    日本外科学会雑誌　104　222-222　2003/04/30

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2132. PP-1-220 肝細胞癌に対する肝移植適応基準の再考 : 過去の肝切除例からの検討

    片寄 友, 鈴木 正徳, 海野 倫明, 竹内 丙午, 水間 正道, 白相 悟, 大塚 英郎, 佐藤 武揚, 大塩 博, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1082-1082　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2133. PP-1-277 肝門部胆管癌に対する至適治療法の選択 : 多変量解析による予後規定因子からの検討

    佐藤 武揚, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1097-1097　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2134. PP-1-263 当科における原発性肝細胞癌に対するOpen MCT群と肝切除群の検討

    林 洋毅, 鈴木 正徳, 水間 正道, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1093-1093　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2135. OP-1-070 進行胆道癌における大動脈周囲リンパ節郭清の適応決定に関する術前MDCTの有用性

    大塚 英郎, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　935-935　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2136. PP-1-097 胆道再建を要しない肝門部癌手術手技 : MDCTを用いたanimated MPR画像からの術前simulation

    鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 小野川 徹, 水間 正道, 佐藤 武揚, 阿部 友哉, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1052-1052　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2137. PP-1-065 肝切除例において吸収性モノフィラメント糸による閉腹は術後創感染を減少させたか?

    水間 正道, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 小野川 徹, 大塚 英郎, 大塩 博, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1044-1044　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2138. PP-1-048 肝門部胆管癌の進展度診断におけるMDCT animated MPR像の有用性

    小野川 徹, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 俊樹, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　1039-1039　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2139. OP-1-165 遠隔成績よりみた食道・胃静脈瘤に対するHassab手術の再評価

    大塩 博, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　959-959　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2140. WS1-04 胆嚢癌の胆嚢周囲進展度(T-factor)からみた治療方針

    海野 倫明, 鈴木 正徳, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　35　(7)　891-891　2002/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2141. Activation of cyclin D1 promoter by Reg for beta-cell regeneration

    H Okamoto, S Takasawa, M Unno, T Ikeda, T Akiyama, K Nata, K Nakagawa, NJ Shervani, D Inoue, S Kawaguchi, T Onogawa, N Noguchi, S Matsuno

    DIABETES　51　A593-A594　2002/06

    ISSN： 0012-1797

  2142. Human 4-1BB ligand発現adenovirusの胆管癌遺伝子免疫治療への応用-SCID mice担癌モデルを用いたin vivo実験からの検討

    吉田 寛, 鈴木 正徳, 海野 倫明, 片寄 友, 兒玉 英謙, 竹村 真一, 浅野 竜太郎, 林 洋毅, 松野 正紀, 工藤 俊雄

    日本外科学会雑誌　103　249-249　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2143. 組み換えアデノウイルス発現系を用いた肝特異的有機アニオントランスポーターLST-1とLST-2の機能解析

    安達 尚宣, 海野 倫明, 鈴木 正徳, 佐々木 剛, 安藤 敏典, 小野川 徹, 藤原 耕, 岡部 光規, 大塚 英郎, 片寄 友, 阿部 高明, 松野 正紀

    日本外科学会雑誌　103　523-523　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2144. 肝特異的有機アニオントランスポーター遺伝子LST-1の転写調節機構と病態への関与

    近藤 典子, 海野 倫明, 藤原 耕, 安達 尚宣, 小野川 徹, 大塚 英郎, 鈴木 正徳, 阿部 高明, 松野 正紀

    日本外科学会雑誌　103　595-595　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2145. ss胆嚢癌に対する肝S4下+S5肝亜2区域切除術の治療成績

    佐藤 武揚, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　103　373-373　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2146. 下大静脈高度圧迫を伴う巨大肝腫瘍症例に対するHanging maneuver法を用いた前方アプローチによる肝切除術

    鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 小野川 徹, 佐藤 武揚, 水間 正道, 松野 正紀

    日本外科学会雑誌　103　286-286　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2147. NADPH oxidase 阻害剤 apocynin の肝再生における効果の検討

    森川 孝則, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　103　495-495　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2148. ヒトにおける甲状腺ホルモン膜輸送は3つの異なるトランスポーターが関与する

    藤原 耕, 海野 倫明, 安達 尚宣, 小野川 徹, 岡部 光規, 竹内 丙午, 片寄 友, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　103　546-546　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2149. LPS刺激によるKupffer細胞NFκB活性化における細胞内低分子鉄の役割

    竹内 丙午, 鈴木 正徳, 海野 倫明, 片寄 友, 松野 正紀

    日本外科学会雑誌　103　153-153　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2150. CDK inhibitor p27/kiplの安定化による胆管癌細胞株に対するアポトーシス増強

    片寄 友, 佐々木 剛, 鈴木 正徳, 海野 倫明, 竹内 丙午, 白相 悟, 水間 正道, 松野 正紀

    日本外科学会雑誌　103　140-140　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2151. 消化器癌に発現している有機アニオントランスポーターLST-2発現量の定量化と抗癌剤治療への応用

    海野 倫明, 大塚 英郎, 小野川 徹, 安藤 敏典, 岡部 光規, 安達 尚宣, 藤原 耕, 近藤 典子, 片寄 友, 竹内 丙午, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　103　163-163　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2152. Multidetector row CTを用いたanimated MPRからの肝門部胆管癌手術の術前シュミレーションの実際

    小野川 徹, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 俊樹, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　103　194-194　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2153. 抗癌剤研究の新たな展開・アドリアマイシンの取り込みを担う新規有機カチオン/アドリアマイシントランスポーターOCA1の解明

    岡部 光規, 海野 倫明, 溝井 賢幸, 石井 誠一, 椎葉 健一, 阿部 高明, 松野 正紀, 佐々木 巌

    日本外科学会雑誌　103　188-188　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2154. 変異型p27/kip1組み込みアデノウイルスベクターによる乳癌に対する新規遺伝子治療

    佐々木 剛, 片寄 友, 鈴木 正徳, 山本 久仁治, 水間 正道, 白相 悟, 海野 倫明, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　103　235-235　2002/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2155. PP214001 消化器癌における新規有機アニオントランスポーターLST-2の発現と癌治療への応用

    小野川 徹, 海野 倫明, 近藤 典子, 安達 尚宣, 藤原 耕, 鈴木 正徳, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　1112-1112　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2156. PS12-02 肝門部胆管癌切除療法の根治度規定因子と術後照射療法の検討

    竹内 丙午, 鈴木 正徳, 海野 倫明, 片寄 友, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　880-880　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2157. PS24-03 肝臓外科周術期管理におけるドレーンパウチ法の検討 : 対費用効率の向上をめざして

    大塚 英郎, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　898-898　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2158. VP30 切除不能肝外胆管癌に対する低侵襲性chemoradiation併用胆道stentingの実際

    鈴木 正徳, 海野 倫明, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　938-938　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2159. PP204022 巨大主腫瘍を有する多発肝細胞癌の治療方針

    片寄 友, 鈴木 正徳, 海野 倫明, 竹内 丙午, 及川 昌也, 水間 正道, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　1059-1059　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2160. PP212006 Human4-1BB ligand発現アデノウイルスの作製と臨床応用 : 胆管癌細胞株を標的とした免疫学的抗腫瘍効果

    吉田 寛, 鈴木 正徳, 海野 倫明, 片寄 友, 竹村 真一, 浅野 竜太郎, 林 洋毅, 松野 正紀, 工藤 俊雄

    日本消化器外科学会雑誌　34　(7)　1098-1098　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2161. S05-09 肝外胆管浸潤様式からみた胆管細胞癌の肉眼分類

    近藤 典子, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　826-826　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2162. PP104075 灌特異的有機アニオントランスポーター遺伝子LST-1の転写調節機構とケノデオキシコール酸の影響

    海野 倫明, 近藤 典子, 藤原 耕, 小野川 徹, 安達 尚宣, 竹内 丙午, 片寄 友, 鈴木 正徳

    日本消化器外科学会雑誌　34　(7)　962-962　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2163. PP104029 肝膵同時切除術後の非実質細胞間相互作用を介した肝再生抑制機序

    及川 昌也, 鈴木 正徳, 海野 倫明, 片寄 友, 力山 敏樹, 竹内 丙午, 内山 哲之, 松野 正紀

    日本消化器外科学会雑誌　34　(7)　956-956　2001/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2164. PP472 外因性液状フィブリン糊製剤の事前調整の可能性をさぐる

    鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 及川 昌也, 竹内 丙午, 近藤 典子, 松野 正紀

    日本外科学会雑誌　102　341-341　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2165. PP475 CDK inhibitor16/INK4Aおよびp27/kiplによるアポトーシスの検討

    佐々木 剛, 片寄 友, 鈴木 正徳, 海野 倫明, 山本 久仁治, キム ミン, Seth Prem, 松野 正紀

    日本外科学会雑誌　102　342-342　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2166. PP399 ラット有機アニオントランスポーターoatp3は回腸刷子縁に存在し, 生理活性物質吸収を支配する

    小野川 徹, 海野 倫明, 阿部 高明, 安達 尚宣, 藤原 耕, 近藤 典子, 岡部 光規, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　102　323-323　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2167. SF4b-4 CDK inhibitor p27/kip1アポトーシスはFas ligandの細胞膜上への提示により開始する

    山本 久仁治, 鈴木 正徳, 片 寄友, 海野 倫明, 佐々木 剛, 松野 正紀

    日本外科学会雑誌　102　78-78　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2168. SF6d-3 変異型SEAを融合したrecombinant bispecific抗体(diabody)による胆管癌養子免疫療法の可能性

    竹村 真一, 鈴木 正徳, 海野 倫明, 片寄 友, 桜井 直樹, 兒玉 英謙, 吉田 寛, 林 洋毅, 工藤 俊雄, 浅野 竜太郎, 熊谷 泉, 津本 浩平, 松野 正紀

    日本外科学会雑誌　102　91-91　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2169. PP1201 消化器癌に発現しMethotrexateを輸送する新規有機アニオントランスポーターLST-2の単離

    岡部 光規, 海野 倫明, 阿部 高明, 小野川 徹, 近藤 典子, 安達 尚宣, 藤原 耕, 椎葉 健一, 佐々木 巌, 松野 正紀

    日本外科学会雑誌　102　524-524　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2170. PP1192 癌抑制遺伝子VHLによるp27/kipl誘導と遺伝子治療の可能性

    片寄 友, 鈴木 正徳, 海野 倫明, 山本 久仁治, 佐々木 剛, キム ミン, Prem Seth, 松野 正紀

    日本外科学会雑誌　102　521-521　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2171. SF14a-4 IVR支援による食道・胃静脈瘤に対するHassab手術の手技簡略化および侵襲軽減の試み

    森川 孝則, 鈴木 正徳, 海野 倫明, 片寄 友, 竹内 丙午, 松野 正紀

    日本外科学会雑誌　102　113-113　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2172. SF21b-4 肝外胆管浸潤様式からみた胆管細胞癌の肉眼分類

    近藤 典子, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 松野 正紀

    日本外科学会雑誌　102　133-133　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2173. PP546 抗癌剤を輸送するトランスポーター遺伝子の発現解析による癌の個性に応じた薬剤選択

    海野 倫明, 阿部 高明, 小野川 徹, 岡部 光規, 近藤 典子, 安達 尚宣, 藤原 耕, 鈴木 正徳, 松野 正紀

    日本外科学会雑誌　102　360-360　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2174. [Molecular identification of organic anion transporter oatp/LST family] (Tanpakushitsu Kakusan Koso)

    Abe T, Unno M, Onogawa T, Tokui T

    Tanpakushitsu Kakusan Koso　46　(5)　612-620　2001

  2175. Malignant pheochromocytoma with hepatic metastasis diagnosed 10 years after a resection of the primary incidentaloma adrenal lesion: report of a case.

    Morikawa T, Suzuki M, Unno M, Endo K, Katayose Y, Matsuno S

    Surg Today　31　(1)　80-84　2001

    DOI： 10.1007/s005950170227 　

    ISSN： 0941-1291

  2176. フィブリン接着剤の現状と展望 組織接着閉鎖剤の種類と特徴

    鈴木正徳, 海野倫明, 片寄友, 竹内丙午, 小野川徹, 大塚英郎, 及川昌也, 松野正紀

    Surgery Frontier　8　(4)　444-448　2001

  2177. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner.

    Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T

    Endocrinology　142　(5)　2005-2012　2001

    DOI： 10.1210/en.142.5.2005 　

  2178. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

    Abe T, Unno M, Onogawa T, Tokui T, Kondo T N, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S

    Gastroenterology　120　(7)　1689-1699　2001

    DOI： 10.1053/gast.2001.24804 　

  2179. PP85 抗体改変による胆管癌に対する免疫療法の新戦略 : signal transduction and targeting

    兒玉 英謙, 工藤 俊雄, 片寄 友, 篠田 雅央, 櫻井 直樹, 竹村 真一, 吉田 寛, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　1030-1030　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2180. PD2-10 肝門部胆管癌に対する合理的な治療戦略 : 遠隔成績からみた当科におけるdecision treeの設定について

    鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 及川 昌也, 竹村 真一, 林 洋毅, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　872-872　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2181. PP10 anaerobic boxを用いたin vitro ischemia-reperfusionによる脂質過酸化物の発生と細胞SOD賦活の意義

    柿田 徹也, 鈴木 正徳, 海野 倫明, 片寄 友, 遠藤 公人, 竹内 丙午, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　1017-1017　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2182. PP5 過大侵襲により誘導されるサイトカイン・IL-10と肝再生への影響

    及川 昌也, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 力山 敏樹, 内山 哲之, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　1016-1016　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2183. PP1440 血小板減少症を伴う肝硬変モデルラットの肝切除後肝再生に対するTPO投与の意義

    竹村 真一, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 吉田 寛, 林 洋毅, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　1255-1255　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2184. PP787 胆管癌・悪性度評価におけるp27の役割と, アポトーシス誘導能からみたメカニズムの解明

    山本 久仁治, 鈴木 正徳, 片寄 友, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　33　(7)　1147-1147　2000/07/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2185. Isolation and functional expression of a receptor for Reg protein

    H Okamoto, S Kobayashi, T Akiyama, K Nata, T Ikeda, M Abe, M Tajima, NJ Shervani, M Unno, S Matsuno, H Sasaki, S Takasawa

    DIABETES　49　A44-A44　2000/05

    ISSN： 0012-1797

  2186. Transcriptional activation of Reg (regenerating gene) by nicotinamide

    H Okamoto, T Akiyama, M Tajima, K Nata, S Kobayashi, M Abe, NJ Shervani, M Unno, T Uchiyama, S Matsuno, S Takasawa

    DIABETES　49　A256-A256　2000/05

    ISSN： 0012-1797

  2187. SF20-5 Fas-Fas Ligand system制御によるアデノウイルスp53およびp27^<kip1>遺伝子治療の新戦略

    片寄 友, 山本 久仁治, 鈴木 正徳, 海野 倫明, 遠藤 公人, Seth Prem, 松野 正紀

    日本外科学会雑誌　101　156-156　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2188. SF3-2 敗血症時の肝細胞障害におけるHO-1とiNOSの役割と相互作用

    岩指 元, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 松野 正紀

    日本外科学会雑誌　101　111-111　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2189. PP-742 肝外胆管浸潤からみた, 新しい胆管細胞癌肉眼分類の必要性

    近藤 典子, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 松野 正紀

    日本外科学会雑誌　101　393-393　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2190. PP-717 Immunomodulatorとして変異型スーパー抗原をバイスペシフィック抗体に応用した胆管癌細胞株(TFK-1)に対する免疫療法の検討

    吉田 寛, 兒玉 英謙, 工藤 俊雄, 片寄 友, 篠田 雅央, 櫻井 直樹, 竹村 真一, 鈴木 正徳, 海野 倫明, 遠藤 公人, 今井 浩三, 松野 正紀

    日本外科学会雑誌　101　386-386　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2191. PP-718 recombinant免疫複合体を用いた胆管癌特異的養子免疫療法のpreclinical study

    竹村 真一, 鈴木 正徳, 海野 倫明, 片寄 友, 桜井 直樹, 児玉 英謙, 吉田 寛, 津本 浩平, 浅野 竜太郎, 熊谷 泉, 工藤 俊雄, 松野 正紀

    日本外科学会雑誌　101　387-387　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2192. PP-679 肝特異的有機アニオントランスポーター遺伝子導入細胞による再構築人工肝細胞の試み

    海野 倫明, 阿部 高明, 鈴木 正徳, 遠藤 公人, 片寄 友, 鹿郷 昌之, 安達 尚宣, 藤原 耕, 岡部 光規, 小野川 徹, 松野 正紀

    日本外科学会雑誌　101　377-377　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2193. PP-678 ラット肝臓特異的新規有機アニオントランスポーターrlst-1の単離と発現調節

    藤原 耕, 阿部 高明, 鹿郷 昌之, 海野 倫明, 鈴木 正徳, 安達 尚宣, 岡部 光規, 小野川 徹, 松野 正紀

    日本外科学会雑誌　101　377-377　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2194. PP-716 QOL向上と生命予後改善の両立を図った切除不能胆道癌に対するchemoradiation併用EMBS療法

    林 洋毅, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 及川 昌也, 藤原 耕, 松野 正紀

    日本外科学会雑誌　101　386-386　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2195. PP-662 脾摘により肝膵同時切除術後の肝再生不全は改善するか

    及川 昌也, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 力山 敏樹, 内山 哲之, 松野 正紀

    日本外科学会雑誌　101　373-373　2000/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2196. 【今日の腫瘍外科 最新の治療指針】 胆道の腫瘍性疾患 胆管癌

    片寄友, 鈴木正徳, 海野倫明, 遠藤公人, 松野正紀

    外科治療　82　(増刊)　903-908　2000

  2197. 今日の腫瘍外科 _ 最新の治療指針 - 胆管癌

    片寄 友, 鈴木 正徳, 海野倫明, 遠藤公人, 松野正紀

    外科治療　82　261-266　2000

  2198. LATE ONSET OF ACUTE GENERALIZED PERITONITIS CAUSED BY INFLAMMATION OF THE REMNANT PANCREAS AFTER PYLORUS PRESERVING PANCREATODUODENECTOMY-A CASE REPORT-

    OIKAWA Masaya, SUZUKI Masanori, UNNO Michiaki, ENDO Kojin, TAKEMURA Shinichi, MATSUNO Seiki

    60　(9)　2484-2488　1999/09/25

    ISSN： 1345-2843

  2199. A CASE OF RUPTURED ANEURYSM OF THE COMMON HEPATIC ARTERY CAUSED BY A DRAIN WHICH A USE OF GRF giue^<<encircled R>> WAS SUCCESSFUL

    TAKEMURA Shinishi, SUZUKI Masanori, UNNO Michiaki, ENDO Koujin, UCHIYAMA Tetsuyuki, MATSUNO Seiki

    60　(6)　1591-1595　1999/06/25

    ISSN： 1345-2843

  2200. W3-12 アデノウイルスp27^<Kip1>による胆管癌細胞株を標的とした遺伝子治療の基礎 : アポトーシスとその機構

    片寄 友, 鈴木 正徳, 海野 倫明, 遠藤 公人, 児玉 英謙, 竹村 真一, 山本 久二治, Cowan Kenneth H., Seth Prem, 松野 正紀

    日本消化器外科学会雑誌　32　(6)　1485-1485　1999/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2201. 1401 extranodalな広がりを示し未分化型腺癌との鑑別に苦慮した、cytokeratin陽性胆管原発悪性リンパ腫の一切除例

    及川 昌也, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 小野 文徳, 山本 久仁治, 松野 正紀, 渡部 みか

    日本消化器外科学会雑誌　32　(6)　1923-1923　1999/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2202. 143 閉塞性黄疸・敗血症時胆汁うっ滞には有機アニオントランスポーター, oatp1, oatp2, oatp3, ntcpの発現低下が関与する

    海野 倫明, 阿部 高明, 内藤 剛, 鹿郷 昌之, 鈴木 正徳, 遠藤 公人, 片寄 友, 松野 正紀

    日本消化器外科学会雑誌　32　(6)　1598-1598　1999/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2203. 肝類洞腔容積調節機序による敗血症治療の可能性〜特異的HO阻害剤を用いた肝機能改善効果の検討

    岩指 元, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 内山 哲之, 松野 正紀

    Shock : 日本Shock学会雑誌　14　(1)　35-35　1999/04/01

    ISSN： 0919-8156

  2204. P-127 肝類洞腔容積調節機序による敗血症治療の可能性 : 特異的HO阻害剤を用いた肝機能改善効果の検討

    岩指 元, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 内山 哲之, 松野 正紀

    日本外科学会雑誌　100　343-343　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2205. O-608 CTAP横断画像からみた胆嚢静脈灌流領域の同定と胆嚢癌における合理的な肝切除範囲の再検討

    山本 久仁治, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本外科学会雑誌　100　259-259　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2206. O-290 ラット肝における3種類の有機アニオントランスポーターの発現 : 敗血症および総胆管結紮モデルでの解析

    海野 倫明, 阿部 高明, 鹿郷 昌之, 鈴木 正徳, 遠藤 公人, 内藤 剛, 八尾 寛, 松野 正紀

    日本外科学会雑誌　100　180-180　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2207. P-458 肝流入血行路遮断を用いた肝切除周術期における末梢血PCOOH測定の臨床的意義

    近藤 典子, 鈴木 正徳, 八巻 孝之, 海野 倫明, 遠藤 公人, 片寄 友, 竹内 丙午, 柿田 徹也, 及川 昌也, 松野 正紀

    日本外科学会雑誌　100　426-426　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2208. P-457 虚血再潅流障害肝における酸化LDLの発現と局在

    遠藤 公人, 鈴木 正徳, 海野 倫明, 八巻 孝之, 柿田 徹也, 松野 正紀, 板部 洋之

    日本外科学会雑誌　100　426-426　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2209. P-170 大腸菌によるDiabodyおよびSEA融合抗体の作製と機能解析 : 胆管癌に対する養子免疫療法への可能性

    竹村 真一, 鈴木 正徳, 海野 倫明, 桜井 直樹, 児玉 英謙, 工藤 俊雄, 熊谷 泉, 松野 正紀

    日本外科学会雑誌　100　354-354　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2210. P-171 変異型スーパー抗原を応用した樹立胆管癌細胞株(TFK-1)に対する免疫療法の検討

    兒玉 英謙, 工藤 俊雄, 片寄 友, 篠田 雅央, 桜井 直樹, 竹村 真一, 鈴木 正徳, 海野 倫明, 遠藤 公人, 今井 浩三, 松野 正紀

    日本外科学会雑誌　100　354-354　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2211. P-229 アデノウイルスp53耐性乳癌細胞株に対するアデノウイルスFasを併用した遺伝子治療の試み

    片寄 友, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀, Kim Min., Cowan Kenneth H., Seth Prem.

    日本外科学会雑誌　100　369-369　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2212. O-197 肝膵同時切除術後のInterleukin-10過剰産生による肝再生抑制

    内山 哲之, 鈴木 正徳, 海野 倫明, 力山 敏樹, 遠藤 公人, 松野 正紀

    日本外科学会雑誌　100　157-157　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2213. O-413 全肝虚血再潅流障害におけるPCOOH測定の有用性 : HA測定による類洞内皮機能評価との比較検討

    八巻 孝之, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 竹内 丙午, 岩指 元, 及川 昌也, 柿田 徹也, 松野 正紀

    日本外科学会雑誌　100　211-211　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2214. O-411 肝虚血再灌流障害における細胞質内SOD賦活の意義 : SOD Transgenic mouse基礎実験からの検討

    柿田 徹也, 鈴木 正徳, 竹内 丙午, 海野 倫明, 遠藤 公人, 八巻 孝之, 松野 正紀

    日本外科学会雑誌　100　210-210　1999/02/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2215. 635 肝虚血再潅流障害評価におけるPCOOH測定の有用性 : 類洞内皮細胞機能評価との比較検討

    八巻 孝之, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 竹内 丙午, 岩指 元, 及川 昌也, 柿田 徹也, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　533-533　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2216. 630 肝類洞腔容積調節機序による敗血症治療の可能性 : 特異的HO阻害剤を用いた肝機能改善効果の検討

    岩指 元, 鈴木 正徳, 海野 倫明, 遠藤 公人, 片寄 友, 内山 哲之, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　531-531　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2217. 示II-141 血漿成分を含まない生体接着剤GRF glueと肝臓外科領域への応用

    及川 昌也, 鈴木 正徳, 内山 哲之, 海野 倫明, 遠藤 公人, 片寄 友, 八巻 孝之, 柿田 徹也, 吉田 寛, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　710-710　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2218. 61 著明な脾機能亢進症を呈する肝硬変モデルラットの確立と肝硬変に対するTPO投与の意義

    竹村 真一, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　386-386　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2219. 482 CTAP横断画像からみた胆嚢静脈灌流領域の同定と胆嚢癌における合理的な肝切除範囲の再検討

    山本 久仁治, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　494-494　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2220. 示II-377 肝動注化学療法後切除した大腸癌肝転移症例の検討

    吉田 寛, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　32　(2)　769-769　1999/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2221. 【3D画像診断の肝胆膵手術への応用】 胆道癌における術前画像診断としての3D-CTの有用性

    鈴木正徳, 海野倫明, 遠藤公人, 片寄友, 児玉英鎌, 柿田徹也, 藤原耕, 松野正紀

    臨床外科　54　(8)　1023-1029　1999

    DOI： 10.11477/mf.1407903691 　

  2222. 胆管癌に対するアデノウイルスp27kip1を用いた遺伝子治療の基礎的研究

    片寄友, 鈴木正徳, 山本久仁治, 海野倫明, 児玉英謙, 竹村真一, 吉田寛, 松野正紀

    胆道　13　(5)　395-402　1999

  2223. 膵β細胞の再生増殖 Reg Iトランスジェニック,ノックアウトマウスを用いた解析

    熊谷 智子, 阿部 倫明, 那谷 耕司, 海野 倫明, 成島 陽一, 加藤 一郎, 小林 誠一, 秋山 貴子, 高沢 伸, 松野 正紀

    生化学　70　(8)　900-900　1998/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  2224. 硬変肝切除後の肝再生と残肝エネルギー代謝に与える外因性脂肪製剤の意義

    坂本 宣英, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 内山 哲之, 松野 正紀

    外科と代謝・栄養　32　(3)　198-198　1998/06/15

    ISSN： 0389-5564

  2225. S1-2 遠隔成績からみた肝細胞癌の治療戦略(第52回日本消化器外科学会総会)

    鈴木 正徳, 海野 倫明, 遠藤 公人, 竹内 丙午, 櫻井 直樹, 児玉 英謙, 及川 昌也, 松野 正紀

    日本消化器外科学会雑誌　31　(6)　1255-1255　1998/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2226. P3-6 遠隔成績よりみた胃・食道静脈瘤に対するHassab手術の有用性(第52回日本消化器外科学会総会)

    岩指 元, 鈴木 正徳, 福原 賢治, 海野 倫明, 松野 正紀

    日本消化器外科学会雑誌　31　(6)　1296-1296　1998/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2227. 示I-299 肝炎症性偽腫瘍の画像診断と外科治療のタイミングについて(第52回日本消化器外科学会総会)

    竹内 丙午, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　31　(6)　1571-1571　1998/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2228. R-35 腹腔鏡下胆摘術後に生じた胆嚢癌巨大肝転移に対する術前門脈塞栓術併施右三区域切除術(第52回日本消化器外科学会総会)

    海野 倫明, 鈴木 正徳, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　31　(6)　1346-1346　1998/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2229. 肝切除後の肝再生とエネルギー代謝に与える外因性脂肪投与の意義

    坂本 宣英, 鈴木 正徳, 海野 倫明, 三国 潤一, 松野 正紀

    日本外科学会雑誌　99　405-405　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2230. 連続虚血および反復虚血時の末梢血PCOOHによる再灌流障害の評価

    八巻 孝之, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 竹内 丙午, 内山 哲之, 岩指 元, 柿田 徹也, 松野 正紀

    日本外科学会雑誌　99　291-291　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2231. 膵ランゲルハンス島再生・増殖因子Reg蛋白 : 膵ランゲルハンス島移植への新しい展望

    海野 倫明, 那谷 耕司, 成島 陽一, 鈴木 正徳, 高沢 伸, 松野 正紀, 岡本 宏

    日本外科学会雑誌　99　263-263　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2232. 好中球およびKupffer細胞機能調節剤による肝虚血・再灌流傷害軽減の試み

    竹内 丙午, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 坂本 宣英, 篠田 雅央, 八巻 孝之, 桜井 直樹, 内山 哲之, 松野 正紀

    日本外科学会雑誌　99　275-275　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2233. ラット再生肝由来の新規ホスホイノシチド3-キナーゼの同定

    小野 文徳, 鈴木 正憲, 海野 倫明, 遠藤 公人, 中川 有, 近藤 尚武, 松野 正紀

    日本外科学会雑誌　99　393-393　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2234. 敗血症治療におけるHO阻害剤投与の可能性 : 肝類洞腔拡張と肝機能改善を指標とする実験的検討

    岩指 元, 鈴木 正徳, 海野 倫明, 遠藤 公人, 松野 正紀

    日本外科学会雑誌　99　328-328　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2235. 遺伝子工学的手法による各種一本鎖抗体(scFv)の作成とそれを用いた胆管癌に対する集学的治療への応用

    桜井 直樹, 鈴木 正徳, 津本 浩平, 海野 倫明, 遠藤 公人, 片寄 友, 寺前 敦司, 榎原 真二, 児玉 英謙, 工藤 俊雄, 今井 浩三, 熊谷 泉, 松野 正紀

    日本外科学会雑誌　99　483-483　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2236. 分子生物学を用いた大腸全摘術後の病態生理解明と治療体系の確立

    福島 浩平, 佐々木 巌, 佐藤 俊, 高橋 賢一, 児山 香, 内藤 広郎, 舟山 裕士, 柴田 近, 海野 倫明, 増子 毅, 小川 仁, 上野 達也, 橋本 明彦, 松野 正紀

    日本外科学会雑誌　99　455-455　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2237. 癌抑制遺伝子p53、サイクリン依存性キナーゼ阻害蛋白p27を組み込んだアデノウイルスを用いた胆管癌に対する遺伝子治療の試み

    片寄 友, 鈴木 正徳, 海野 倫明, 遠藤 公人, 篠田 雅央, 櫻井 直樹, 児玉 英謙, Li Zhaungwu, Rakkar Amol, Cown Kennneth H., Seth Perm, 松野 正紀

    日本外科学会雑誌　99　422-422　1998/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  2238. P-4-8 遠隔成績よりみた食道・胃静脈瘤に対する外科治療の再評価 (<パネルディスカッション4> 食道静脈瘤に対する治療戦略の再考)

    鈴木 正徳, 岩指 元, 福原 賢治, 海野 倫明, 松野 正紀

    日本消化器外科学会雑誌　31　(2)　342-342　1998/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2239. II-143 大腸癌肝転移に対する系統的肝切除の意義

    海野 倫明, 鈴木 正徳, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　31　(2)　651-651　1998/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2240. IV-184 横断画像上Segment IXが明瞭に識別できた肝門部癌の一例

    柿田 徹也, 鈴木 正徳, 海野 倫明, 遠藤 公人, 坂 宣英, 竹内 丙午, 内山 哲之, 岩指 元, 及川 昌也, 松野 正紀

    日本消化器外科学会雑誌　31　(2)　787-787　1998/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2241. VS-5-2 高度進行肝癌に対する積極的肝切除術 : Vp3・腹壁播種合併肝細胞癌症例に対する外科治療 (<ビデオシンポジウム5> 高度進行肝癌の切除)

    遠藤 公人, 鈴木 正徳, 海野 倫明, 松野 正紀

    日本消化器外科学会雑誌　31　(2)　315-315　1998/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2242. VS3-4 肝外発育型肝細胞癌における他臓器合併切除併施肝切除術 : 切離局所流入・流出血行路遮断による肝切除術(<特集>第50回日本消化器外科学会総会)

    鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1241-1241　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2243. VS4-5 ss 胆嚢癌に対する合理的リンパ節郭清とは?(<特集>第50回日本消化器外科学会総会)

    海野 倫明, 鈴木 正徳, 福原 賢治, 遠藤 公人, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1247-1247　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2244. II-247 肝切除後の肝再生とエネルギー代謝に与える外因性脂肪投与の影響(<特集>第50回日本消化器外科学会総会)

    坂本 宣英, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 三国 潤一, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1660-1660　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2245. II-303 スーパー抗原を応用した肝外胆管癌細胞株に対する特異的免疫療法の実験的検討(<特集>第50回日本消化器外科学会総会)

    篠田 雅央, 工藤 俊雄, 片寄 友, 櫻井 直樹, 鈴木 正徳, 福原 賢治, 海野 倫明, 佐伯 久明, 今井 浩三, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1674-1674　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2246. 402 肝細胞癌切除49例における各種診断画像の術前診断能と術後再発病巣の検出能について(<特集>第50回日本消化器外科学会総会)

    児玉 英輔, 鈴木 正徳, 福原 賢治, 海野 倫明, 遠藤 公人, 竹内 丙午, 八巻 孝之, 内山 哲之, 岩指 元, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1454-1454　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2247. I-35 遠隔成績よりみた食道静脈瘤直達手術の再評価 : 自検293症例からの検討(<特集>第50回日本消化器外科学会総会)

    岩指 元, 鈴木 正徳, 福原 賢治, 海野 倫明, 松野 正紀

    日本消化器外科学会雑誌　30　(6)　1509-1509　1997/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2248. I-215 肝虚血再潅流における末梢血中細胞膜脂質過酸化物 phosphatidylcholine hydroperoxide (PCOOH) 測定の意義(<特集>第49回日本消化器外科学会総会)

    竹内 丙午, Tint Htwe, 鈴木 正徳, 福原 賢治, 海野 倫明, 成島 陽一, 坂本 宣英, 篠田 雅央, 八巻 孝之, 松野 正紀

    日本消化器外科学会雑誌　30　(2)　532-532　1997/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2249. W3-6 ss 胆嚢癌に対する外科治療の strategy : 拡大胆摘は妥当か否か(<特集>第49回日本消化器外科学会総会)

    海野 倫明, 鈴木 正徳, 福原 賢治, 松野 正紀

    日本消化器外科学会雑誌　30　(2)　326-326　1997/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2250. 腺癌関連抗原MUC1に対する抗体の遺伝子工学的発現系の構築

    櫻井 直樹, 津本 浩平, 寺前 敦司, 鈴木 正徳, 福原 賢治, 海野 倫明, 片寄 友, 工藤 俊雄, 今井 浩三, 松野 正紀, 熊谷 泉

    日本分子生物学会年会プログラム・講演要旨集　19　720-720　1996/08/01

  2251. I-204 肝膵同時切除後のKupffer 細胞を介した肝再生抑制機構に関する実験的検討(<特集>第48回日本消化器外科学会総会)

    力山 敏樹, 鈴木 正徳, 福原 賢治, 海野 倫明, 坂本 宣英, 竹内 丙午, 内山 哲之, 松野 正紀

    日本消化器外科学会雑誌　29　(6)　1465-1465　1996/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2252. V2-2 吸収性テープおよび各種結紮用器械を用いた肝切除術(<特集>第47回日本消化器外科学会総会)

    鈴木 正徳, 福原 賢治, 海野 倫明, 三国 潤一, 松野 正紀

    日本消化器外科学会雑誌　29　(2)　276-276　1996/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2253. H1-11 年齢別にみた大腸癌手術症例(<特集>第47回日本消化器外科学会総会)

    佐々木 浩一, 山崎 匡, 伊藤 賢司, 高橋 正倫, 海野 倫明, 伊藤 浩司, 八岡 利彦, 田中 正彦, 正宗 智子, 山本 庸子, 及川 昌也, 北山 卓, 星 光世

    日本消化器外科学会雑誌　29　(2)　491-491　1996/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2254. 示-530 肝嚢胞性疾患47切除例の検討 : 鑑別診断における嚢胞穿刺液の性状に注目して(<特集>第46回日本消化器外科学会)

    竹内 丙午, 鈴木 正徳, 福原 賢治, 海野 倫明, 武藤 大成, 坂本 宣英, 篠田 雅央, 松野 雅紀

    日本消化器外科学会雑誌　28　(6)　1609-1609　1995/06/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2255. Nicotinamide inhibits IRF-1 mRNA induction and prvents IL-1β-induced nitric oxide synthase expression in pancreatic β cells

    AKABANE A.

    Biochem Biophys Res Commun　215　(2)　524-530　1995

    DOI： 10.1006/bbrc.1995.2496 　

    ISSN： 0006-291X

  2256. 示-127 選択的動脈内セクレチン注入試験が部位診断に有用であったZollinger-Ellison症候群の一例(<特集>第37回日本消化器外科学会総会)

    柴田 近, 佐々木 巌, 内藤 広郎, 舟山 裕士, 神山 泰彦, 高橋 道長, 福島 浩平, 瀬上 秀雄, 土井 孝志, 大谷 典也, 岩附 昭広, 松野 正紀, 野村 泰輔, 海野 倫明, 岡本 宏

    日本消化器外科学会雑誌　24　(2)　717-717　1991/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2257. 145. 根治不能胆管癌の palliative therapy : 改良型アプリケータを用いたRALS胆管腔内照射療法と Laser cholangioplasty(<特集>第35回日本消化器外科学会総会)

    鈴木 正徳, 三国 潤一, 武藤 大成, 海野 倫明, 福原 賢治, 菅野 明弘, 富永 剛, 田辺 淳, 松原 修二, 大内 清昭, 松野 正紀

    日本消化器外科学会雑誌　23　(2)　351-351　1990/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  2258. 【膵神経内分泌腫瘍-診断と治療のパラダイムシフト-】外科治療 Debulking surgeryの位置づけ

    青木 豪, 大学院医学系研究科病態学講座消化器外科学, 大塚 英郎, 水間 正道, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    肝・胆・膵(0389-4991)78巻1号 Page73-78(2019.01)

  2259. 【膵神経内分泌腫瘍の診療ガイドライン改訂にむけての諸問題】膵神経内分泌癌に対する外科的治療

    青木 豪, 学, 消化器外科学, 大塚 英郎, 水間 正道, 森川 孝則, 元井 冬彦, 亀井 尚, 内藤 剛, 海野 倫明

    胆と膵(0388-9408)40巻2号 Page129-133(2019.02)

  2260. 【高度進行消化器癌に対する手術】肝・胆・膵 広範囲膵頭体部癌に対する膵全摘(残膵全摘を含む)

    伊関 雅裕, 総合外科, 水間 正道, 林 洋毅, 森川 孝則, 元井 冬彦, 海野 倫明

    手術(0037-4423)73巻4号 Page649-655(2019.03)

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Books and Other Publications 11

  1. 胆と膵 Vol.39 No.3(3 2 特集:胆嚢癌ー術前診断に応じた治療を再考する

    海野倫明

    医学図書出版　2018/04/01

    ISBN: 9784865172614

  2. 肝胆膵高難度外科手術

    日本肝胆膵外科学会高度技能医制度委員会, d, 海野倫明

    医学書院　2016/11

    ISBN: 9784260027922

  3. 膵癌治療up‐to‐date〈2015〉

    跡見 裕, 海野 倫明, 土田 明彦

    医学図書出版　2014/12/05

    ISBN: 4865170871

  4. 膵癌治療up‐to‐date

    海野 倫明, 土田 明彦, 跡見 裕

    医学図書出版　2014

    ISBN: 9784865170870

  5. 消化器外科学レビュー2009

    炭山嘉伸, 門田守人, 跡見 裕, ds, 海野倫明

    総合医学社　2009/03

  6. 消化器癌の外科治療：こんなときどうするQ&A(2)

    上西紀夫, 中尾昭公, ds, 海野倫明

    中外医学社出版　2008/10

  7. 消化器癌の外科治療：こんなときどうするQ&A

    上西紀夫, 中尾昭公, ds, 海野倫明

    中外医学社出版　2008/10/01

  8. 消化器癌・乳癌に発現する有機アニオントランスポーターの機能と腫瘍生物学的意義

    海野 倫明

    [海野倫明]　2008

  9. 臨床に直結する肝・胆・膵疾患治療のエビデンス

    跡見裕, 植村直実, 白鳥敬子, 正木尚彦, s, 林洋毅, 海野倫明

    文光堂　2007/10/02

  10. Reg-Reg受容体系によるヒト消化器癌の増殖・浸潤能・予後の解明

    海野 倫明

    [海野倫明]　2006

  11. 肝特異的トランスポーター遺伝子の発現調節機構の解明と肝疾患治療への応用

    海野 倫明

    [海野倫明]　2002

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Presentations 212

  1. 心嚢液貯留高度進行食道癌に対して細胞診を先行し根治切除を施行した1例

    堀内 真, 谷山 裕亮, 丸山 祥太, 岡本 宏史, 高屋 快, 瓶子 隆弘, 櫻井 直, 亀井 尚, 海野 倫明

    日本食道学会学術集会プログラム・抄録集　2018/06

  2. 腹腔鏡下脾温存膵体尾部切除術の術後成績 脾合併切除術との比較から

    森川 孝則, 石田 晶玄, 高舘 達之, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　2018/05

  3. 膵管内乳頭粘液性腺癌の予測診断における血清抗p53抗体測定の意義

    畠 達夫, 水間 正道, 元井 冬彦, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 亀井 尚, 内藤 剛, 古川 徹, 江川 新一, 海野 倫明

    膵臓　2018/05

  4. 膵粘液性嚢胞腫瘍(MCN)の治療戦略の検討

    高舘 達之, 森川 孝則, 畠 達夫, 伊関 雅裕, 有明 恭平, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 水間 正道, 中川 圭, 林 洋毅, 元井 冬彦, 亀井 尚, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　2018/05

  5. 当院における非機能性pNENの予後についての検討

    滝川 哲也, 菅野 敦, 本郷 星仁, 鍋島 立秀, 三浦 晋, 濱田 晋, 粂 潔, 菊田 和宏, 元井 冬彦, 海野 倫明, 藤島 史喜, 下瀬川 徹, 正宗 淳

    膵臓　2018/05

  6. CD-DST法を用いた抗癌剤感受性試験は膵癌術後補助治療の有効性を予測する

    有明 恭平, 元井 冬彦, 水間 正道, 林 洋毅, 大塚 英郎, 深瀬 耕二, 益田 邦洋, 高舘 達之, 畠 達夫, 内藤 剛, 亀井 尚, 海野 倫明

    膵臓　2018/05

  7. 動脈接触膵頭部癌に対する集学的治療戦略

    元井 冬彦, 畠 達夫, 有明 恭平, 青木 豪, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 内藤 剛, 江川 新一, 海野 倫明

    膵臓　2018/05

  8. 膵管内乳頭粘液性腫瘍の発生・進展における染色体不安定性の関与

    畠 達夫, 水間 正道, 元井 冬彦, 海野 倫明, Goggins Michael

    膵臓　2018/05

  9. プロテオミクス解析により発見した膵神経内分泌腫瘍の新規肝転移関連因子

    志村 充広, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 青木 豪, 深瀬 耕二, 森川 孝則, 中川 圭, 林 洋毅, 元井 冬彦, 内藤 剛, 海野 倫明

    膵臓　2018/05

  10. 初診時局所進行切除不能膵癌に対する治療戦略

    林 洋毅, 有明 恭平, 水間 正道, 畠 達夫, 伊関 雅裕, 高舘 達之, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 江川 新一, 亀井 尚, 海野 倫明

    膵臓　2018/05

  11. 膵癌における術前治療と効果判定-画像・病理診断と腫瘍マーカーを中心に- 膵癌術前治療における組織効果と画像・腫瘍マーカーの変化との関係

    水間 正道, 元井 冬彦, 畠 達夫, 伊関 雅裕, 有明 恭平, 高舘 達之, 益田 邦洋, 青木 豪, 石田 晶玄, 深瀬 耕二, 大塚 英郎, 森川 孝則, 中川 圭, 林 洋毅, 内藤 剛, 亀井 尚, 菅野 敦, 正宗 淳, 古川 徹, 海野 倫明

    膵臓　2018/05

  12. 切除不能膵癌における治療方針-conversion surgeryの是非- 切除不能膵癌に対するConversion Surgeryの意義

    元井 冬彦, 海野 倫明, 膵癌術前治療研究会

    膵臓　2018/05

  13. 先天性胆道拡張症、膵・胆管合流異常における術後長期合併症の検討

    大塚 英郎, 畠 達夫, 伊関 雅裕, 高舘 達之, 有明 恭平, 益田 邦洋, 石田 晶玄, 深瀬 耕二, 水間 正道, 林 洋毅, 中川 圭, 森川 孝則, 元井 冬彦, 内藤 剛, 亀井 尚, 海野 倫明

    日本小児外科学会雑誌　2018/05

  14. 女性外科医のキャリアパス 女性医師支援の現状把握と今後の展望

    佐藤 章子, 多田 寛, 渡部 剛, 宮下 穣, 原田 成美, 濱中 洋平, 内藤 剛, 海野 倫明, 亀井 尚, 石田 孝宣

    日本外科学会定期学術集会抄録集　2018/04

  15. Neoadjuvant chemotherapyの現状と将来展望

    海野 倫明

    日本外科学会定期学術集会抄録集　2018/04

  16. 胆管癌診断・治療の新しい展開

    海野倫明

    第54回佐賀胆膵研究会　2010/11/26

  17. Recent Progress in Surgical Resection and Multidiscipilinary Therapy for Cholangiocarcinoma International-presentation

    Unno M

    14th Taiwan Cooperative Oncology Group Meeting　2010/11/20

  18. 大腸癌肝転移の外科治療

    海野倫明

    第627回奥州市医師会医学講演会　2010/10/26

  19. 胆道癌診断・治療の最前線

    海野倫明

    第26回長崎肝・胆・膵外科研究会　2010/10/09

  20. 膵癌・胆道癌治療医から分析科学に望むもの

    海野倫明

    第23回バイオメディカル分析科学シンポジウム　2010/07/22

  21. 胆管癌・膵癌治療のブレークスルーを目指して

    海野倫明

    第41回肝胆膵治療研究会　2010/07/21

  22. FFPE（ホルマリン固定パラフィン包埋）標本からのプロテオミクス

    海野倫明, 小野川 徹, 前田晋平, 高館達之, 森川孝則, 江川新一, 片寄 友

    第65回日本消化器外科学会総会　2010/07/14

  23. 肝胆膵がん術前化学療法の現況と緩和医療

    海野倫明

    第2回千葉がん治療緩和ケア講演会　2010/06/16

  24. 大腸癌肝転移の対する外科治療と薬物療法の接点

    海野倫明

    Yokohama Surgical Oncology Forum　2010/06/04

  25. Next Generationを育てる

    海野倫明

    第22回日本肝胆膵外科学会学術集会　2010/05/26

  26. 肝胆膵外科疾患の臨床研究推進を目指して

    海野倫明

    消化器外科共同研究会第1回肝胆膵疾患分科会　2010/04/14

  27. 膵癌切除後，腫瘍マーカー正常化維持期間の臨床的意義

    元井冬彦, 力山敏樹, 片寄 友, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  28. 胆嚢癌におけるEGFR発現と病理学的因子および予後との関係

    林 洋毅, 片寄 友, 力山敏樹, 元井冬彦, 赤田昌紀, 山本久仁治, 吉田 寛, 小野川徹, 森川孝則, 中川 圭, 乙供 茂, 大村範幸, 大塚英郎, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  29. 大腸癌肝転移切除例に対するmFOLFOX6補助化学療法の安全性に関する検討（多施設共同第II相臨床試験）

    山本久仁治, 片寄 友, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  30. GC-binding factor 2がもたらす癌細胞の転移・浸潤メカニズムの解明

    有明恭平, 大塚英郎, 元井冬彦, 大村範幸, 川口 桂, 藤川奈々子, 力山敏樹, 片寄 友, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  31. 膵内分泌腫瘍肝転移例におけるSSTRの発現とその治療戦略

    大塚英郎, 有明恭平, 元井冬彦, 片寄 友, 江川新一, 力山敏樹, 赤田昌紀, 山本久仁治, 小野川徹, 吉田 寛, 森川孝則, 林 洋毅, 中川 圭, 乙供 茂, 大村範幸, 海野倫明

    第110回日本外科学会総会　2010/04/08

  32. 肝胆膵外科領域における周術期フォンダパリヌクス使用の検討

    森川孝則, 片寄 友, 力山敏樹, 元井冬彦, 赤田昌紀, 小野川徹, 山本久仁治, 吉田 寛, 中川 圭, 林 洋毅, 大塚英郎, 乙供 茂, 大村範幸, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  33. LC-MS/MSによる網羅的蛋白質同時絶対定量法に基づく新規抗癌剤感受性予測とテーラーメード治療への応用

    川口 桂, 元井冬彦, 大峰 健, 藤川奈々子, 有明恭平, 大塚英郎, 大槻純夫, 寺崎哲也, 力山敏樹, 片寄 友, 江川新一, 海野倫明

    第110回日本外科学会総会　2010/04/08

  34. 肝胆膵領域におけるHarmonic FOCUSの使用経験

    力山敏樹

    第110回日本外科学会総会　2010/04/08

  35. 胆道癌診断・治療の新展開

    海野倫明

    第2回南多摩消化器がんセミナー　2010/03/27

  36. 胆管癌治療のup to date

    海野倫明

    第103回大阪胆道疾患研究会　2010/03/18

  37. Neoadjuvant chemotherapyについて

    海野倫明

    ELPLAT講演会　2010/02/06

  38. 胆管癌治療の新展開と緩和医療

    海野倫明

    第2回大阪緩和医療研究会　2009/11/27

  39. 肝門部胆管癌治療の新展開

    海野倫明

    第25回富山肝臓セミナー　2009/11/13

  40. 消化器がん治療における疼痛マネジメント

    海野倫明

    Yamagata Cancer pain Management WorkShop　2009/10/16

  41. 膵癌・胆道癌の術前補助療法

    海野倫明

    第16回外科フォーラム　2009/08/01

  42. 胆管癌治療の最前線

    海野倫明

    宮崎緩和ケアセミナー　2009/07/03

  43. 胆道癌・膵癌治療の新展開

    海野倫明

    第26回日本胆膵生理機能研究会　2009/06/27

  44. 胆道癌治療の最前線

    海野倫明

    第18回北九州代謝栄養研究会　2009/06/15

  45. 高度技能医制度

    海野倫明

    題21回日本肝胆膵外科学会　2009/06/10

  46. 21世紀の肝胆膵外科を考える

    海野倫明

    第30回21世紀外科フォーラム　2009/05/21

  47. 胆管癌治療の新しい展開

    海野倫明

    兵庫県消化器外科研究会2009　2009/05/15

  48. 胆道癌における進展度診断の体系化と新展開

    海野倫明

    第109回日本外科学会定期学術集会　2009/04/02

  49. 胆道癌治療の新しい展開

    海野倫明

    熊本術後障害特別講演会　2009/02/06

  50. 大腸癌肝転移治療の新しい展開

    海野倫明

    第3回久留米消化器癌化学療法懇話会　2009/02/03

  51. 胆道癌治療の新展開

    海野倫明

    第59回山口県難治性肝疾患研究会　2009/01/28

  52. 「肝門部胆管癌の術前診断と外科治療」

    海野倫明

    第9回千駄木消化器癌セミナー　2008/09/09

  53. 胆道癌の外科治療ー術前放射線化学療法への取り組みー

    海野倫明

    第30回奈良県肝胆膵研究会　2008/06/21

  54. 膵癌の治療

    海野倫明

    仙北消化器疾患研究会　2008/06/18

  55. 胆道癌外科治療の術前診断と周術期管理

    海野倫明

    第20回日本肝胆膵外科学会学術集会　2008/05/28

  56. 肝門部胆管癌の外科治療と新しい展開

    海野倫明

    第12回北陸肝胆膵外科研究会　2008/02/23

  57. 胆管癌の外科治療と新しい展開

    海野倫明

    第３回消化器外科手術を考える若手懇談会　2008/02/02

  58. 瘍マーカー(TM)は、切除後補助化学療法の効果予測指標となりうるか?

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    第45回日本癌治療学会総会　2007/10/24

  59. 転移性インスリノーマに対する集学的治療

    青木豪, 元井冬彦, 吉田寛, 山本久仁治, 小野川徹, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    第45回日本癌治療学会総会　2007/10/24

  60. 当科における上部胃癌手術症例の臨床病理学的検討

    木内誠, 柴田近, 三浦康, 上野達也, 小林照忠, 小山淳, 小川仁, 福島浩平, 舟山裕士, 海野倫明, 佐々木巌

    第45回日本癌治療学会総会　2007/10/24

  61. 胃癌術後の腫瘍性イレウスに対する手術例の検討

    小林照忠, 三浦康, 柴田近, 上野達也, 木内誠, 小山淳, 大沼忍, 佐々木宏之, 高見一弘, 海野倫明, 佐々木巌

    第45回日本癌治療学会総会　2007/10/24

  62. 胆道系悪性腫瘍に対する治療戦略 胆道癌に対する治療戦略 術前化学放射線療法の意義と安全性

    片寄友, 小野川徹, 岡上能斗竜, 林洋毅, 力山敏樹, 山本久仁治, 吉田寛, 大塚英郎, 江川新一, 海野倫明

    第45回日本癌治療学会総会　2007/10/24

  63. GISTとの鑑別に難渋した退形成性膵管癌（破骨細胞型巨細胞癌）の1例

    横山 智, 砂村眞琴, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 海野倫明, 渡辺みか

    第61回日本消化器外科学会　2007/10/19

  64. Circadian gene mPer2 overexpression inhibits growth of human cancer cell and makes a good combination with cisplatinum

    小田聡, 片寄友, 力山敏樹, 江川新一, 薮内新一, 海野倫明

    第66回日本癌学会学術総会　2007/10/03

  65. 肝門部胆管癌の外科切除成績と治療方針

    力山敏樹, 片寄 友, 山本久仁治, 小野川徹, 吉田 寛, 林 洋毅, 大塚英郎, 海野倫明

    第43回日本胆道学会学術集会　2007/09/28

  66. T2以深胆嚢癌に対する肝切除・肝外胆管切除・膵頭十二指腸切除の意義

    林 洋毅, 片寄 友, 力山敏樹, 福山尚治, 元井冬彦, 山本久仁治, 小野川徹, 吉田 寛, 岡田恭穂, 神賀貴大, 大塚英郎, 江川新一, 海野倫明

    第43回日本胆道学会学術集会　2007/09/27

  67. 胆道癌に対する補助療法-外来抗癌剤の安全性とコンプライアンス

    片寄 友, 小野川 徹, 岡上能斗竜, 力山敏樹, 山本久仁治, 吉田 寛, 林 洋毅, 大塚英郎, 佐藤龍一郎, 渡部康弘, 益田邦洋, 江川新一, 海野倫明

    第43回日本胆道学会学術集会　2007/09/27

  68. 術後8年目に再発した壊死性膵仮性嚢胞に対するネクロセクトミーと嚢胞空腸吻合の1例

    有明恭平, 森川孝則, 山本久仁治, 小野川徹, 元井冬彦, 力山敏樹, 福山尚治, 片寄友, 江川新一, 海野倫明

    第154回東北外科集談会　2007/09/15

  69. 膵臓に発生した顆粒細胞腫の一例

    前田晋平, 坂田直昭, 吉田寛, 小野川徹, 山本久仁治, 元井冬彦, 力山敏樹, 福山尚治, 片寄友, 江川新一, 海野倫明

    第154回東北外科集談会　2007/09/15

  70. 大腸癌肝転移術後の補助化学療法としてのmFOLFOX6法の第II相臨床試験

    山本久仁治, 片寄友, 齋藤善広, 浅沼拓, 椎葉健一, 佐藤正幸, 内山哲之, 阿部友哉, 福原賢治, 横山忠明, 丹野弘晃, 赤田昌紀, 阿部忠義, 黒田房邦, 竹村真一, 海野倫明

    第154回東北外科集談会　2007/09/15

  71. 肝機能障害を伴う両葉多結節Vp4肝癌破裂症例に対する1切除例

    北村洋, 片寄友, 力山と式, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 大塚英郎, 森川孝則, 元井冬彦, 福山尚治, 江川新一, 海野倫明

    第154回東北外科集談会　2007/09/15

  72. 肝門部胆管癌治療の最前線

    海野倫明

    県南中核病院講演会　2007/09/11

  73. 肝門部胆管癌治療の最前線

    海野倫明

    第187回大分県外科医会　2007/09/08

  74. LAPAROSCOPIC SURGERY FOR PANCREAS. International-presentation

    Fukuyama S, Egawa S, Onogawa T, Yoshida H, Yamamoto K, Hayashi H, Kamiga T, Sakata N, Mikami Y, Motoi F, Rikiyama T, Katayose Y, Unno M

    the 42nd World Congress of Surgery of the International Society of Surgery　2007/08/26

  75. 肝門部胆管癌の外科治療

    海野倫明

    外科フォーラム　2007/07/28

  76. 胆石を伴う急性胆嚢炎と周術期管理

    海野倫明

    日本消化器外科学会教育集会　2007/07/20

  77. 肝胆膵癌に対する補助療法の位置づけ 胆管癌に対するアジュバントの現状と術前化学放射線療法の可能性

    片寄友, 小野川徹, 力山敏樹, 山本久仁治, 吉田寛, 林洋毅, 江川新一, 福山尚治, 元井冬彦, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  78. 胆管癌に対する拡大手術の適応と限界 治療成績向上のためには?

    力山敏樹, 片寄友, 元井冬彦, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 福山尚治, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  79. Stage IVa膵癌の治療戦略 切除可能膵癌に対するゲムシタビン(GEM)による術前化学療法(NAC)の試み

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  80. 結腸癌fStageIII症例におけるD3郭清の検討

    唐澤秀明, 三浦康, 小林照忠, 木内誠, 小山淳, 柴田近, 福島浩平, 舟山裕士, 海野倫明, 佐々木巖

    第62回日本消化器外科学会　2007/07/18

  81. Chronic intestinal pseudo-obstruction(CIP)に対する外科治療(5例の経験)

    上野達也, 柴田近, 小林照忠, 木内誠, 舟山裕士, 福島浩平, 内山哲之, 北山卓, 海野倫明, 佐々木巌

    第62回日本消化器外科学会　2007/07/18

  82. 急激な経過をたどった骨盤内anaplastic large cell lymphomaの1例

    高見一弘, 三浦康, 溝井賢幸, 小林照忠, 木内誠, 小山淳, 大沼忍, 佐々木宏之, 海野倫明, 佐々木巌

    第62回日本消化器外科学会　2007/07/18

  83. ダウン症候群に合併した膵管胆道合流異常症と胆嚢癌の1例

    神賀貴大, 丹野弘晃, 安西良一, 赤田昌紀, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  84. 石灰化慢性膵炎に合併した膵管内乳頭粘液性腫瘍(IPMN)症例の検討

    青木豪, 江川新一, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  85. 膵indeterminate mucin-producing cystic neoplasmと考えられた粘液産生膵腫瘍の2例

    石田晶玄, 江川新一, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 森谷卓也, 古川徹, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  86. 脾疾患に対する腹腔鏡手術の優位性の検討

    福山尚治, 江川新一, 神賀貴大, 坂田直昭, 三上幸夫, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  87. 当科における硬化性胆管炎手術例の検討

    岡上能斗竜, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  88. 大腸癌細胞同所移植自然転移モデルを用いた転移能と遺伝子発現プロファイルの解析(続報)

    佐々木宏之, 三浦康, 小林照忠, 木内誠, 小山淳, 舟山裕士, 海野倫明, 佐々木巌, 藤渕航

    第62回日本消化器外科学会　2007/07/18

  89. 膵島移植に対する膵全摘ならびに亜全摘症例の検討

    坂田直昭, 元井冬彦, 三上幸夫, 福山尚治, 力山敏樹, 片寄友, 江川新一, 後藤昌史, 岡芳知, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  90. 食道浸潤胃癌の臨床病理学的検討

    木内誠, 柴田近, 三浦康, 小林照忠, 上野達也, 小山淳, 福島浩平, 舟山裕士, 海野倫明, 佐々木巌

    第62回日本消化器外科学会　2007/07/18

  91. 十二指腸癌異時性両側卵巣転移の1例

    横山智, 元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 森谷卓也, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  92. ラット急性膵炎モデルにおける走査型電子顕微鏡による膵微小血管病変の観察

    三上幸夫, 福山尚治, 坂田直昭, 元井冬彦, 江川新一, 武田和憲, 大塚愛二, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  93. 進行胆嚢癌に対する拡大手術の適応と意義

    林洋毅, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 福山尚治, 元井冬彦, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  94. 幽門側胃切除術後の残胃の癌に対する臨床病理学的検討

    小林照忠, 柴田近, 上野達也, 木内誠, 三浦康, 小山淳, 大沼忍, 佐々木宏之, 海野倫明, 佐々木巌

    第62回日本消化器外科学会　2007/07/18

  95. 腹腔鏡下胃切除術の成績と問題点

    鹿郷昌之, 徳村弘実, 舟山裕士, 福島浩平, 柴田近, 三浦康, 小林照忠, 小川仁, 海野倫明, 佐々木巌

    第62回日本消化器外科学会　2007/07/18

  96. 肝切除、胆道再建を伴う胆道癌手術における術後経管栄養の有用性

    佐藤龍一郎, 片寄友, 力山敏樹, 山本久仁治, 吉田寛, 小野川徹, 林洋毅, 福山尚治, 江川新一, 海野倫明

    第62回日本消化器外科学会　2007/07/18

  97. 当科におけるpSM結腸癌, 直腸癌手術症例の検討

    小山 淳, 三浦 康, 唐澤秀明, 金子直征, 高見一弘, 佐々木宏之, 大沼 忍, 木内 誠, 小林照忠, 柴田 近, 福島浩平, 舟山裕士, 海野倫明, 佐々木 巖

    第67回大腸癌研究会　2007/07/06

  98. situation of laparoscopic surgery for pancreatic disease International-presentation

    Fukuyama S, Egawa S, Onogawa T, Yoshida H, Yamamoto K, Hayashi H, Kamiga T, Sakata N, Mikami Y, Motoi F, Rikiyama T, Katayose Y, Unno M

    15th International Congress of the European Association for Endoscopic Surgery　2007/07/01

  99. 膵頭十二指腸切除後仮性動脈瘤破裂に対し特異な血管走行形態のために救命しえた1例

    川口桂, 江川新一, 神賀貴大, 林洋毅, 小野川徹, 元井冬彦, 力山敏樹, 福山尚治, 片寄友, 海野倫明

    第38回日本膵臓学会　2007/06/28

  100. 当科における膵癌症例22例に対するPET-CTの経験

    横山智, 元井冬彦, 川口桂, 塚本信和, 青木豪, 石田晶玄, 大石英和, 神賀貴大, 坂田直昭, 三上幸夫, 福山尚治, 江川新一, 海野倫明

    第38回日本膵臓学会　2007/06/28

  101. 胆管狭窄合併症例に対するFreyの手術の検討

    塚本信和, 元井冬彦, 川口桂, 横山智, 青木豪, 坂田直昭, 神賀貴大, 福山尚治, 江川新一, 海野倫明

    第38回日本膵臓学会　2007/06/28

  102. 当科で経験した膵全摘並びに亜全摘症例の膵島移植適応に関する検討

    坂田直昭, 元井冬彦, 三上幸夫, 石田晶玄, 川口桂, 横山智, 塚本信和, 青木豪, 大石英和, 神賀貴大, 福山尚治, 江川新一, 後藤昌, 岡芳知, 海野倫明

    第38回日本膵臓学会　2007/06/28

  103. 当施設における腹腔鏡下膵切除術の経験(

    福山尚治, 江川新一, 神賀貴大, 坂田直昭, 三上幸夫, 元井冬彦, 海野倫明

    第38回日本膵臓学会　2007/06/28

  104. 性膵内分泌腫瘍に対する治療 2症例の検討を踏まえて

    青木豪, 元井冬彦, 川口桂, 横山智, 塚本信和, 坂田直昭, 神賀貴大, 福山尚治, 江川新一, 海野倫明

    第38回日本膵臓学会　2007/06/28

  105. 通常型膵癌切除後腫瘍マーカーの推移を利用した再発予後予測の有用性

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    第38回日本膵臓学会　2007/06/28

  106. 急性膵炎重症化機序と長期予後 膵血管病変を中心とした急性膵炎重症化機序の検討

    三上幸夫, 武田和憲, 福山尚治, 元井冬彦, 片寄友, 江川新一, 大塚愛二, 海野倫明

    第38回日本膵臓学会　2007/06/28

  107. 肝内胆管癌に対する治療戦略

    吉田 寛, 片寄 友, 力山敏樹, 小野川徹, 山本久仁治, 林 洋毅, 海野倫明

    第43回日本肝癌研究会　2007/06/21

  108. 特別教育カリキュラム？この症例をどうする？

    海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  109. ディベート（肝門部胆管癌）

    海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  110. リンパ節転移個数と予後-肝門部胆管癌切除例での検討

    片寄 友, 力山敏樹, 山本久仁治, 小野川 徹, 吉田 寛, 林 洋毅, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  111. 中下部胆管癌の切除成績-治療成績向上のためには?

    力山敏樹, 片寄友, 福山尚治, 元井冬彦, 山本久仁治, 小野川徹, 吉田 寛, 三上幸夫, 林 洋毅, 神賀貴大, 坂田直昭, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  112. 高度進行胆道癌に対するネオアジュバント放射線化学療法

    小野川徹, 片寄 友, 力山敏樹, 山本久仁治, 吉田 寛, 林 洋毅, 福山尚治, 元井冬彦, 三上幸夫, 坂田直昭, 神賀貴大, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  113. 膵全摘術を施行された13例に対する膵島移植の適応について

    坂田直昭, 元井冬彦, 三上幸夫, 神賀貴大, 林洋毅, 小野川徹, 山本久仁治, 吉田寛, 福山尚治, 力山俊樹, 片寄友, 江川新一, 後藤昌史, 岡芳知, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  114. 膵癌切除後の血清腫瘍マーカー非正常化の意義

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  115. 当施設における腹腔鏡下尾側膵切除術の経験

    福山尚治, 江川新一, 林洋毅, 小野川徹, 山本久仁治, 吉田寛, 神賀貴大, 坂田直昭, 三上幸夫, 元井冬彦, 力山敏樹, 片寄友, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  116. 播種性病変を伴った悪性膵内分泌腫瘍の２切除例

    青木豪, 元井冬彦, 川口桂, 横山智, 塚本信和, 石田晶玄, 大石英和, 坂田直昭, 神賀貴大, 三上幸夫, 福山尚治, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  117. 先天性胆道拡張症術後長期成績の検討

    吉田 寛, 片寄 友, 力山敏樹, 小野川徹, 山本久仁治, 林 洋毅, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  118. 肝門部胆管癌との鑑別に苦慮したIgG4関連硬化性胆管炎の一切除例

    武藤満完, 片寄 友, 力山敏樹, 小野川徹, 山本久仁治, 吉田 寛, 林 洋毅, 江川新一, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  119. 胆嚢癌における上皮増殖因子受容体(EGFR)の発現と病理組織学的因子・予後の検討

    林 洋毅, 片寄 友, 力山敏樹, 山本久仁治, 小野川徹, 吉田 寛, 渡部泰弘, 浅野竜太郎, 海野倫明

    第19回日本肝胆膵外科学会　2007/06/06

  120. Surgical Treatment for Primary Gastric Lymphoma. International-presentation

    Ohnuma S, Miura K, Shibata C, Kobayashi T, Ueno T, Kinouchi M, Funayama Y, Fukushima K, Takahashi K, Ogawa H, Oyama A, Sasaki H, Takami K, Karasawa H, Kaneko N, Moriya T, Unno M, Sasaki I

    7th International Gastric Cancer Congress　2007/05/01

  121. 膵管内乳頭粘液腫瘍切除例の長期予後と再発例

    元井冬彦, 福山尚治, 力山敏樹, 片寄友, 江川新一, 海野倫明

    第93回日本消化器病学会総会　2007/04/19

  122. 胃悪性リンパ腫に対する手術治療の意義

    大沼 忍, 三浦 康, 柴田 近, 小林照忠, 上野達也, 木内 誠, 舟山裕士, 福島浩平, 高橋賢一, 小川 仁, 鹿郷昌之, 小山 淳, 長尾宗紀, 佐々木宏之, 高見一弘, 金子直征, 唐澤秀明, 海野

    第93回日本消化器病学会総会　2007/04/19

  123. ガストリノーマの診断、治療におけるグルカゴン負荷試験の役割

    柴田近, 小林照忠, 上野達也, 木内誠, 舟山裕士, 福島浩平, 溝井賢幸, 三浦康, 高橋賢一, 小川仁, 小山淳, 大沼忍, 佐々木宏之, 高見一弘, 金子直征, 唐澤秀明, 工藤克昌, 神山篤史, 林啓

    第93回日本消化器病学会総会　2007/04/19

  124. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. International-presentation

    Onogawa T, Katayose Y, Suzuki T, Sasano H, Abe T, Unno M

    98th Annual Meeting of American Assositation for Cancer Research　2007/04/14

  125. Ectopic expression of PIK3CD in human cancer cell lines and human lung carcinoma. International-presentation

    Nakamura H, Dan S, Akashi T, Okui M, Ishikawa Y, Unno M, Yamori T

    98th Annual Meeting of American Association for Cancer Research　2007/04/14

  126. 中下部胆管癌の切除成績と適正切除範囲 治療成績向上のためには?

    力山敏樹, 片寄友, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  127. 全国膵癌登録データからみたJPS第5版取扱い規約とUICC第6版取扱い規約の比較

    江川新一, 当間宏樹, 水元一博, 中尾昭公, 田中雅夫, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  128. 胆道癌術前診断におけるFDG-PETの意義 リンパ節転移と間質浸潤診断について

    山本久仁治, 片寄友, 力山敏樹, 小野川徹, 吉田寛, 林洋毅, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  129. 先天性胆道拡張症術後の肝内結石症

    吉田寛, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 林洋毅, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  130. 膵管内乳頭粘液性腫瘍のsubtypeと通常型膵癌、他臓器悪性腫瘍合併の相関

    川口桂, 江川新一, 横山智, 青木豪, 石田晶玄, 坂田直昭, 三上幸夫, 元井冬彦, 福山尚治, 森谷卓也, 古川徹, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  131. 抗癌剤投与下の膵癌における網羅的遺伝子・メタボローム解析

    石田晶玄, 砂村眞琴, 紙健次郎, 曽我朋義, 阿部忠義, 江川新一, 堀井明, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  132. ヒト大腸癌細胞株を用いたCPT-11,Oxaliplatin感受性・耐性遺伝子群の抽出とその臨床応用

    高見一弘, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 佐々木宏之, 金子直征, 唐澤秀明, 舟山裕士, 福島浩平, 柴田近, 高橋賢一, 小川仁, 上野達也, 佐々木巌, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  133. 大腸癌5-FU耐性関連遺伝子の機能解析

    佐々木宏之, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 小山淳, 大沼忍, 高見一弘, 唐澤秀明, 金子直征, 舟山裕士, 福島浩平, 柴田近, 高橋賢一, 小川仁, 上野達也, 佐々木巌, 海野倫明, 藤渕

    第107回日本外科学会定期学術集会　2007/04/11

  134. 胆道再建を伴う肝切除術後の経管栄養の検討

    佐藤龍一郎, 片寄友, 力山敏樹, 山本久仁治, 小野川徹, 吉田寛, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  135. 肝門部・上部胆管癌におけるリンパ節転移個数の予後規定因子としての意義

    片寄友, 力山敏樹, 小野川徹, 山本久仁治, 吉田寛, 林洋毅, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  136. 幽門側胃切除Uncut Roux-en Y再建症例の検討

    柴田近, 小林照忠, 上野達也, 木内誠, 舟山裕士, 福島浩平, 溝井賢幸, 三浦康, 高橋賢一, 小川仁, 小山淳, 大沼忍, 佐々木宏之, 高見一弘, 金子直征, 唐澤秀明, 工藤克昌, 神山篤史, 林啓

    第107回日本外科学会定期学術集会　2007/04/11

  137. TS1を中心とした術前化学療法後に切除した高度進行胃癌症例の検討

    木内誠, 三浦康, 柴田近, 溝井賢幸, 小林照忠, 上野達也, 小山淳, 小川仁, 高橋賢一, 福島浩平, 舟山裕士, 海野倫明, 佐々木巌

    第107回日本外科学会定期学術集会　2007/04/11

  138. 膵疾患に対する内視鏡下手術の現状の検討

    福山尚治, 江川新一, 坂田直昭, 神賀貴大, 三上幸夫, 元井冬彦, 海野倫明

    第107回日本外科学会定期学術集会　2007/04/11

  139. LAPAROSCOPIC SURGERY FOR PANCREATIC DISEASE International-presentation

    Fukuyama S, Egawa S, Onogawa T, Yoshida H, Yamamoto K, Hayashi H, Kamiga T, Sakata N, Mikami Y, Motoi F, Rikiyama T, Katayose Y, Unno M

    2007 Annual Meeting of Society of American Gastrointestinal Endoscopic Surgeons　2007/04/01

  140. A case of Partial Response of Liver Metastases after Treatment with Somatostatin Analogue for a Malignant Insulinoma International-presentation

    Aoki T, Egawa S, Sakata N, Kamiga T, Mikami Y, Motoi F, Fukuyama S, Unno M

    1st the Asian-Pacific Hepato-Pancreato-Biliary Association　2007/03/21

  141. Hyperglycemia and diabetic renal change in a model of PVA bio-artificial pancreas transplantation International-presentation

    Sakata N, Sumi S, Gu Y, Qi M, Yamamoto C, Mikami Y, Motoi F, Fukuyama S, Egawa S, Sunamura M, Matsuno S, Unno M, Inoue K

    1st the Asian-Pacific Hepato-Pancreato-Biliary Association　2007/03/21

  142. the present situation of laparoscopic surgery for pancreatic disease in our institution International-presentation

    Fukuyama S, Egawa S, Onogawa T, Yoshida H, Yamamoto K, Hayashi H, Kamiga T, Sakata N, Mikami Y, Motoi F, Rikiyama T, Katayose Y, Unno M

    1st the Asian-Pacific Hepato-Pancreato-Biliary Association　2007/03/21

  143. 胆道癌の治療成績向上を目指して

    海野倫明

    いわき艮陵会　2007/02/24

  144. 胆道癌治療の新しい展開

    海野倫明

    第182回日本消化器病学会東北支部例会　2007/02/24

  145. 高度進行胆道癌に対するネオアジュバント放射線化学療法

    小野川徹, 片寄 友, 力山敏樹, 山本久仁治, 吉田 寛, 林 洋毅, 武藤満完, 小田 聡, 佐藤隆一郎, 渡部康弘, 益田邦洋, 岡上能斗竜, 川口 桂, 海野倫明

    第182回日本消化器病学会東北支部例会　2007/02/24

  146. 局所進行膵癌に対する治療戦略：ゲムシタビンの有用性の検証と術前化学療法の試み

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    第182回日本消化器病学会東北支部例会　2007/02/10

  147. 石灰化慢性膵炎に発生したIPMN症例の検討

    青木 豪, 元井冬彦, 江川新一, 海野倫明

    第41回東北膵臓研究会　2007/02/09

  148. 膵癌に対する塩酸ゲムシタビン化学療法施行中の間質性肺炎

    元井冬彦, 福山尚治, 江川新一, 海野倫明

    第68回日本臨床外科学会総会　2006/11/09

  149. 糖尿病性腎障害ならびに生命予後に関するカプセル化膵島異種移植の有効性

    坂田直昭, 角昭一郎, 顧元駿, 奇梅日更, 日裏彰人, 元井冬彦, 江川新一, 砂村眞琴, 井上一知, 海野倫明

    第44回日本人工臓器学会大会　2006/10/31

  150. 急性胆道炎ガイドラインについて

    海野倫明

    第6回いわき胆膵疾患研究会学術講演会　2006/10/27

  151. 肝門部胆管癌の成績向上を目指して：アジュバント療法の現状と今後

    片寄 友, 力山 敏樹, 小野川 徹, 山本久仁治, 吉田 寛, 林 洋毅, 佐藤龍一郎, 渡部康弘, 益田邦洋, 海野倫明

    第44回日本癌治療学会　2006/10/18

  152. 進行膵癌切除後腫瘍マーカー非正常化の臨床的意義

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第44回日本癌治療学会　2006/10/18

  153. 術前化学療法後に切除した高度進行胃癌症例の検討

    木内 誠, 溝井賢幸, 柴田 近, 小林照忠, 上野達也, 海野倫明, 佐々木巌

    第44回日本癌治療学会　2006/10/18

  154. 膵癌に対するα１樹状細胞を用いた免疫治療第1相試験

    江川新一, 砂村眞琴, 海野倫明

    第48回日本消化器病学会大会　2006/10/11

  155. 進行膵癌切除後腫瘍マーカー非正常化の臨床的意義

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第48回日本消化器病学会大会　2006/10/11

  156. インスリノーマに対する腹腔鏡手術の経験

    福山尚治, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 海野倫明

    第48回日本消化器病学会大会　2006/10/11

  157. 拡張型膵管胆道合流異常の胆嚢癌・胆管癌同時重複発癌の1根治切除例

    渡部泰弘, 片寄 友, 力山敏樹, 及川昌也, 小野川徹, 山本久仁治, 林 洋毅, 山本陽一朗, 福本 学, 海野倫明

    第29回膵・胆管合流異常究会　2006/10/06

  158. 肝門部胆管癌外科治療の課題と今後の展開を考える

    海野倫明

    第6回千葉肝胆膵フォーラム　2006/09/30

  159. 膵癌登録のための連結可能匿名化プログラムの開発

    江川新一, 田中雅夫, 元井冬彦, 福山尚治, 松野正紀, 海野倫明

    第65回日本癌学会学術総会　2006/09/28

  160. 塩酸ゲムシタビン無効膵癌に対するタキサンによる２次治療

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 海野倫明

    第65回日本がん学会学術総会　2006/09/28

  161. Notch signal伝達経路を標的とした新規膵癌治療戦略

    大石英和, 砂村眞琴, 江川新一, 元井冬彦, 福山尚治, 阿部 永, 大村範幸, 海野倫明, 八木田秀雄

    第65回日本癌学会学術総会　2006/09/28

  162. ヒト大腸癌細胞株を用いたCPT-11,Oxaliplatin感受性耐性遺伝子のスクリーニングと機能解析

    高見一弘, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 大沼忍, 佐々木宏之, 金子直征, 唐澤秀明, 海野倫明, 佐々木巖

    第65回日本癌学会学術総会　2006/09/28

  163. PI3キナーゼ 触媒サブユニット サブタイプ（α, β, δ, γ）のmRNA発現解析

    中村啓之, 旦 慎吾, 海野倫明, 矢守隆夫

    第65回 日本癌学会学術総会　2006/09/28

  164. 胆道癌にネオアジュバント放射線化学療法を施行した1例

    小野川徹, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 吉田寛, 林洋毅, 海野倫明

    第42回日本胆道学会　2006/09/15

  165. 胆管内乳頭状腫瘍(intraductal papillary neoplasm of the bile duct,IPN-B)の診断と手術成績

    片寄友, 小田聡, 力山敏樹, 小野川徹, 山本久仁治, 海野倫明

    第42回日本胆道学会　2006/09/15

  166. ss胆嚢癌の診断と治療 ss胆嚢癌の予後規定因子

    林洋毅, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 吉田寛, 海野倫明

    第42回日本胆道学会　2006/09/15

  167. CLINICAL FEATURES OF MUCIN-PRODUCING BILIARY TUMORS:COMPARISON WITH INTRADUCTAL PAPILLARY CHOLANGIOCARICNOMA International-presentation

    Katayose Y, Oda A, Matsuda K, Rikiyama T, Onogawa T, Yamamoto K, Yoshida H, Unno M

    International Hepato Pancreato Biliary Association　2006/09/03

  168. 外科医が求める胆道癌の術前画像診断

    海野倫明

    第104回東北画像診断研究会　2006/08/05

  169. 胆膵癌における化学療法の有用性 臨床病理学的因子からみた通常型膵癌切除後補助療法としての塩酸ゲムシタビンの有用性

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  170. 巨大な1型早期胃癌を合併したCronkhite-Canada症候群の1例

    唐澤秀明, 溝井賢幸, 三浦康, 小林照忠, 平賀雅樹, 木内誠, 森谷卓也, 海野倫明, 佐々木巌

    第61回日本消化器外科学会　2006/07/13

  171. 直腸骨盤内腫瘍のリンパ節転移診断に関するPET(PET-CT)の有用性の検討

    平賀雅樹, 溝井賢幸, 三浦康, 小林照忠, 木内誠, 海野倫明, 佐々木巖

    第61回日本消化器外科学会　2006/07/13

  172. 当科にて経験したIPMN切除例における同時性・異時性他臓器癌合併例の検討

    青木豪, 元井冬彦, 石田晶玄, 大石英和, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  173. 胆道癌肝切除症例における閉鎖式低圧持続吸引ドレナージの効果

    益田邦洋, 片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 林 洋毅, 武藤満完, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  174. 重症急性膵炎における輸液管理

    三上幸夫, 福山尚治, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  175. 肝門部胆管癌術後補助化学療法の可能性

    片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 林 洋毅, 小田 聡, 武藤満完, 佐藤龍一郎, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  176. 切除不能胆管癌に対する集学的治療―その後の経口化学療法

    佐藤龍一郎, 片寄 友, 力山敏樹, 及川昌也, 山本久仁冶, 林 洋毅, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  177. 小腸リンパ管拡張症の一例

    林 啓一, 舟山裕士, 海野倫明, 佐々木巌

    第61回日本消化器外科学会　2006/07/13

  178. 詳細な病理学的検討により診断した胃未分化癌の1例

    高見一弘, 佐々木巌, 海野倫明, 森谷卓也, 溝井賢幸, 柴田 近, 三浦 康, 小林照忠, 平賀雅樹, 木内 誠

    第61回日本消化器外科学会　2006/07/13

  179. 胃悪性リンパ腫に対する手術治療の意義

    大沼 忍, 溝井賢幸, 三浦 康, 小林照忠, 平賀雅樹, 木内 誠, 柴田 近, 森谷卓也, 海野倫明, 佐々木巖

    第61回日本消化器外科学会　2006/07/13

  180. 大腸癌細胞同所移植転移モデルでの転移能に相関する遺伝子発現プロファイル解析（続報）

    佐々木宏之, 溝井賢幸, 三浦 康, 小林照忠, 平賀雅樹, 木内 誠, 海野倫明, 佐々木巌, 藤渕 航

    第61回日本消化器外科学会　2006/07/13

  181. 原発性虫垂腫瘍8例の検討

    金子直征, 溝井賢幸, 小林照忠, 平賀雅樹, 木内 誠, 海野倫明, 佐々木巌

    第61回日本消化器外科学会　2006/07/13

  182. 放射線化学療法後再発した肛門扁平上皮癌の2例

    田中直樹, 溝井賢幸, 三浦 康, 小林照忠, 平賀雅樹, 木内 誠, 海野倫明, 佐々木巌

    第61回日本消化器外科学会　2006/07/13

  183. 脾疾患に対する鏡視下手術の利点の検討

    福山尚治, 江川新一, 三上幸夫, 元井冬彦, 阿部忠義, 砂村眞琴, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  184. 膵全摘術の適応と術後長期成績

    大石英和, 江川新一, 元井冬彦, 阿部忠義, 福山尚治, 砂村真琴, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  185. 膵頭十二指腸切除術後のクリニカルパス

    江川新一, 砂村眞琴, 三上幸夫, 元井冬彦, 阿部忠義, 福山尚治, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  186. Whole Genome Amplificationを利用した膵癌の遺伝子診断

    阿部忠義, 砂村眞琴, 江川新一, 福山尚治, 元井冬彦, 福重真一, 堀井 明, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  187. 膵癌治療における抗癌剤に関わる遺伝子と臨床成績

    石田晶玄, 元井冬彦, チョンチョルウン, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 堀井 明, 海野倫明

    第61回日本消化器外科学会　2006/07/13

  188. 非Ｂ非Ｃ型肝細胞癌に関する臨床的検討

    山本久仁治, 片寄 友, 力山敏樹, 及川昌也, 小野川 徹, 林 洋毅, 海野倫明

    第42回日本肝癌研究会　2006/07/06

  189. 胆管細胞癌・転移性肝癌に対する外科治療戦略

    海野倫明

    北九州肝癌治療研究会　2006/07/01

  190. 膵癌進行度診断 画像診断はどこまで正確か MD-CTを用いた膵癌術前Stagingの評価:病理所見との対比

    元井冬彦, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第38回日本膵臓学会　2006/06/28

  191. 悪性インスリノーマ多発肝転移に対しオクトレオチドにて長期生存を得られている1例

    青木豪, 元井冬彦, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第38回日本膵臓学会　2006/06/28

  192. 当施設における膵疾患に対する腹腔鏡下手術の現況

    福山尚治, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    第38回日本膵臓学会　2006/06/28

  193. 膵外傷9例の検討

    石田晶玄, 元井冬彦, 塚本信和, 横山智, 青木豪, 大石英和, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第38回日本膵臓学会　2006/06/28

  194. Notch signaling pathwayを標的とした腫瘍血管新生抑制療法

    大石英和, 砂村真琴, 江川新一, 元井冬彦, 福山尚治, 阿部忠義, 阿部永, 大村範幸, 海野倫明, 八木田秀雄

    第38回日本膵臓学会　2006/06/28

  195. PanIN病変,膵癌のWhole Genome Amplificationを用いたゲノム解析

    阿部忠義, 砂村眞琴, 江川新一, 福山尚治, 元井冬彦, 福重真一, 堀井明, 海野倫明

    第38回日本膵臓学会　2006/06/28

  196. 肝門部胆管癌外科治療における感染症対策

    海野倫明

    徳島SSIセミナー　2006/06/24

  197. Gefinitib(IRESSA®)によるCDK inhibitor p27誘導機構の解明

    片寄 友, 藪内伸一, 小野川徹, 林 洋毅, 海野倫明

    第10回がん分子標的治療研究会　2006/06/15

  198. 腸アニサキス症の3例

    石田晶玄, 原田昭彦, 渡部秀一, 蝦名宣男, 海野倫明

    第141回東北外科集談会　2006/06/10

  199. 高度進行胆嚢癌に対してGemcitabine+Capecitabine併用療法（GemCap療法）を施行した1例

    林 洋毅, 片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 海野倫明

    第141回東北外科集談会　2006/06/10

  200. 肝門部胆管癌に対する診断と治療の進歩

    海野倫明

    福島肝胆膵疾患研究会　2006/06/03

  201. 膵内分泌腫瘍に対する腹腔鏡下核出術

    石田晶玄, 福山尚治, 塚本信和, 横山 智, 青木 豪, 大石英和, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 砂村眞琴, 海野倫明

    第18回日本内分泌外科学会総会　2006/05/12

  202. 術前および病理組織学的に肝内胆管癌との鑑別に苦慮した膵癌肝転移症例

    中村啓之, 片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 林 洋毅, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  203. 胆嚢癌，胆管癌同時性重複発癌を来した拡張型膵胆管合流異常症の根治切除の1例

    渡部泰弘, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 林 洋毅, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  204. 胆摘後に偶然発見された胆嚢癌症例の検討

    林 洋毅, 片寄 友, 力山敏樹, 及川昌也, 山本久仁治, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  205. 肝門部胆管癌根治術後に膵内胆管癌の異時性発生をきたした１例

    佐藤龍一郎, 片寄友, 力山敏樹, 及川昌也, 山本久仁治, 小野川徹, 林洋毅, 古川 徹, 海野倫明

    第18回 日本肝胆膵外科関連会議　2006/05/10

  206. インスリノーマに対する腹腔鏡手術症例の報告

    福山尚治, 三上幸夫, 元井冬彦, 阿部忠義, 江川新一, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  207. 術前stagingと病理stagingの対比からみた局所進行膵癌に対する治療方針

    元井冬彦, 砂村眞琴, 阿部忠義, 福山尚治, 江川新一, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  208. 膵粘液性嚢胞腫瘍(MCN)におけるAd4BP/SF-1 の発現の検討

    青木 豪, 砂村眞琴, 石田和之, 石田晶玄, 大石英和, 大村範幸, 元井冬彦, 阿部忠義, 福山尚治, 江川新一, 森谷卓也, 海野倫明

    第18回日本肝胆膵外科関連会議　2006/05/10

  209. 肝門部胆管癌における門脈分岐変異時の胆管形態と術式選択

    力山敏樹, 北見昌広, 片寄 友, 及川昌也, 山本久仁治, 林 洋毅, 佐藤明弘, 石橋忠司, 海野倫明

    第18回日本肝胆膵外科学会　2006/05/10

  210. 膵腺扁平上皮癌切除例の検討

    元井冬彦, 古川 徹, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第92回日本消化器病学会総会　2006/04/20

  211. 膵漿液性嚢胞腺腫（serous cystadenoma）切除9例の検討

    青木 豪, 元井冬彦, 三上幸夫, 阿部忠義, 福山尚治, 江川新一, 砂村眞琴, 海野倫明

    第92回 日本消化器病学会総会　2006/04/20

  212. Search for tumor suppressor genes on chromosome 18 in pancreatic cancer. International-presentation

    Ishida M, Egawa S, Motoi F, Abe T, Fukuyama S, Sunamura M, Unno M

    97th American Association for Cancer Research　2006/04/01

Show all Show first 5

Research Projects 34

  1. 患者のフィジビリティを高める遠隔看護システム併用型「膵がんリハプログラム」の開発

    佐藤 菜保子, 霜山 真, 佐藤 大介, 元井 冬彦, 岸和田 昌之, 中谷 直樹, 森下 慎一郎, 海野 倫明, 奥坂 拓志

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 福島県立医科大学

    2024/04/01 - 2029/03/31

  2. 切除不能な肝門部領域胆管癌に対する生体肝移植で治癒に至る分子生物学的特性の解明

    日比 泰造, 大段 秀樹, 大平 真裕, 武冨 紹信, 海野 倫明, 北川 雄光, 長谷川 潔, 小倉 靖弘, 波多野 悦朗, 楳田 祐三, 高田 泰次, 吉住 朋晴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 熊本大学

    2023/04/01 - 2028/03/31

  3. Elucidation of the mechanism of intractability of pancreatobiliary cancers using patients-derived organoids

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2026/03/31

  4. Elucidation of the mechanism of intractability of pancreatobiliary cancers using patients-derived organoids

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2026/03/31

  5. A novel therapeutic strategy for pancreatic and biliary tract cancer by targeting the intestinal microbiota for anti-tumor immune activation

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  6. 膵癌細胞に発現したCRH系ペプチドは癌の進行と情動に介在するか

    佐藤 菜保子, 鈴木 貴, 海野 倫明, 元井 冬彦, 佐藤 冨美子, 吉田 詩織

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 福島県立医科大学

    2019/04/01 - 2023/03/31

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    本研究は膵癌術後患者を対象とし、免疫・ストレスに重要な役割を担うCorticotropin-Releasing Hormone (CRH)系分子の膵癌細胞組織における発現と自律神経内分泌系を介した癌の進行および情動との関連を臨床的に明らかにすることを目的とする。 膵癌患者を対象とした先行研究において、患者のQuality of Life (QOL)は術後生存の予測因子のひとつである可能性が示されている。抑うつはCRHが関与する情動反応のひとつであり、QOLを構成する要素でもある。癌患者の抑うつは一般人と比較し多く、CRH receptor 1の刺激は不安を惹起することがすでに明らかにされており、癌患者の抑うつは疾患に伴う精神的ストレッサーに対する反応としての一側面から考えるだけではなく、生体が癌により直接受けているストレスが脳へシグナル伝達された結果の情動反応である可能性が示唆される。他癌ではCRHによる癌増殖等の関与も報告されているが膵癌においてはまだ未解明である。本研究により膵癌におけるCRHの作用の方向性を臨床的な解明は、癌における心身相関を検証するための重要な根拠のひとつとなりうる。 本研究では前向きコホート研究によって臨床症例による膵癌組織に発現したCRH系分子それに関連した生理学的指標、癌の進行と情動、QOLなどの患者のストレス関連症状の介在可能性の検討を行う。調査は東北最大の膵癌外科治療のhigh volume centerで実施し、膵癌に対する一定の治療条件のもとデータを蓄積する。 令和3年度は、令和2年度までに登録した被験者の追跡調査の継続、および引き続き適格基準を満たす被験者登録を継続した。

  7. Elucidation the mechanism of metastasis caused by GCF2 gene mutasion in bile duct cancer

    fukase koji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    In this study, we evaluated the metastatic potential induced by the cancer associated factor (CAF) of gallbladder cancer. CAF was established from surgical specimens of gallbladder cancer and fibroblasts (NF) were established from normal gallbladder tissue and their effects on mobility were evaluated. The mobility was enhanced in specific CAFs compared to NFs. It was shown that the Conditioned Medium (CM) from CAFs enhances the migration and invasion activity of gallbladder cancer cell lines. Microarray analysis revealed that Tenascin-C (TNC) and Podoplanin (PDPN) contribute to promote cell morbidity. Immunostaining showed that the recurrence-free survival and the overall survival were significantly poor in the cases with high expression of TNC and PDPN. From the above, it was shown that there are CAFs that express TNC and PDPN in gallbladder cancer and that they promote the progression of cancer.

  8. The role of Glycolipids on the pathogenesis of inflammatory bowel disease.

    OGAWA HITOSHI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku Medical and Pharmaceutical University

    2017/04/01 - 2020/03/31

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    As a result of comparing the expression of GM3 in the inflamed and non-inflamed sites of normal colon mucosa and ulcerative colitis obtained from surgical specimens by the HPTLC method, GM3 expression was enhanced in the inflamed site mucosa of ulcerative colitis. It was also found that LacCer expression was increased in the ulcerative colitis inflamed mucosa, while HexCer expression was decreased, and that HexCer was also decreased in the non-inflamed site as compared with the normal mucosa. These results suggest that gangliosides are also altered in non-inflamed areas, that is, they are involved in the very early stages of pathogenesis.

  9. Comparing pancreatic ductal adenocarciinoma and cholangiocarcinoma to elucidate the mechanism of carcinogenesis

    UNNO MICHIAKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2016/04/01 - 2020/03/31

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    Pancreatic ductal adenocarcinoma(PDAC), cholangiocarcinoma(CC), intraductal papillary mucous neoplasm (IPMN), and intraductal papillary neoplasm of the bile duct (IPN-B) are considered to be similar tumors, but the differences in their molecular basis are not clear. A comprehensive proteomic analysis of PDAC and CC shows that some protein expression patterns differ significantly. The results indicate that the differential diagnosis of PDAC and CC can be made by immunohistochemistry. IPN-B was subclassified morphologically into types 1 and 2. Gene mutation analysis revealed that type 1 was more similar to IPMN and type 2 was more similar to PDAC than IIPMN. Moreover, the Japan-Korea joint study compared the prognosis of the patients of IPN-B type1 and type2, and found that this hypothesis was supported by the results of the study.

  10. Regulation of epithelial-mesenchymal transition and application to new treatment for pancreatic cancer

    Unno Michiaki, OHTSUKA HIDEO, ARIAKE KYOHEI, DOUCHI DAISUKE

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2014/04/01 - 2016/03/31

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    Outcome of pancreatic cancer is very miserable due to the recurrence of distant metastasis. The distant metastases were associated with epithelial-mesenchymal transition (EMT) . In this study, we examined the relationship between Wnt signal and EMT, and also relationship if EMT and sensitivity of anti-cancer drug. When Wnt signal was inhibited by introducing SiRNA of LRRFIP1 into pancreatic cancer cell line Panc-1, we showed that reverse EMT was observed. Moreover, we revealed that the sensitivity of anti-cancer drug was increased in this situation. Therefore, we indicated that there was a strong relationship between the EMT and sensitivity for anti-cancer drugs in pancreatic cancer cells.

  11. Prediction of sensitivity and tolerance of anticancer drug for biliary tract cancer by applying a combination of targeted proteomics and metabolomic analyses.

    UNNO Michiaki, KATAYOSE Yu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2010 - 2012

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    To predict the effect of anti-cancer drugs, such as gemcitabine in pancreatic cancer and biliary tract cancer, is also crucial to improve QOL of patients not only improve the survival rate. By combination of targeted proteomics and metabolomic analysese, we investigated the quantitation of membrane transporters and enzymes for drug metabolism using the biliary tract cancer and pancreatic cancer cell line. We found that reduced expression of deoxycitidine kinase (dCK) are brought anticancer drug resistance. Now, we are analyzing the surgical specimens of biliary tract cancer and pancreatic cancer and referring to clinical outcome.

  12. Research and development of liver regeneration with autologous bone marrow cell transplantation against the limitation of major hepatectomy

    RIKIYAMA Toshiki, HAYASHI Hiroki, UNNO Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    2010 - 2012

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    We intraperitoneally-administered carbon tetrachloride (CCl4) tosevere immunodeficient mouse (NOG mouse) and created chronic liver injury modeland hepatic failure model. We transplanted bone marrow cells of GFP-positive NOG mice into tail vein, small numb

  13. 小動物用マイクロCTを使用した標本画像解析による膵・胆道癌徴細構造の検討

    海野 倫明, 吉田 寛

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 挑戦的萌芽研究

    Category: 挑戦的萌芽研究

    Institution: 東北大学

    2009 - 2010

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    肝胆膵領域の外科標本は消化管(胃・小腸・大腸)の切除術によって得られた標本とは異なり、標本を立体的に再構築し脈管や切除断端との立体的相互位置関係を把握することが重要である。特に膵臓癌や胆道癌、膵嚢胞性病変(IPMN,MCN)や胆管内乳頭状腺腫(IPN-B)などでは、3次元的な立体的病変把握と微細病変の検出は病態解明のため極めて重要である。本研究は、小動物用マイクロCTを使用して、肝臓・胆道や膵臓などの実質臓器を摘出後速やかに標本CT画像を撮像することで病変の立体的病変把握と微細病変の評価を行おうとするものである。当初はリース契約により小動物用CTを導入し本研究に使用する予定であったが、平成21年度に東北大学大学院医学系研究科の共同実験施設にアロカ社製実験動物用CT(ALOKAラシータLCT-200)が導入されたため、本研究はアロカ社製動物実験用CTを使用した。同機器の使用方法講習会を受講し使用許可を得た後、担当者と打ち合わせ、実験の概要を検討した。LCT-200を用いてラット胆管造影撮影の条件を決定し、そのデータをアロカ社に供与した。ラット胆管にウロラフィン造影剤を注入し撮像し、またラット肝臓を摘出し標本とした後に胆管にカニュレーションを施行しウログラフィンを注入、胆管樹が描出された。本データは今後臨床検体を用いる際に条件決定に使用される。

  14. Function and role for organic anion transporter expressed in gastrointestinal and breast cancer

    UNNO Michiaki, ABE Takaaki, KATAYOSE Yu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2005 - 2007

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    Human liver-specific organic anion transporter-2 (LST-2/OATP8/SLCO1B3) has been demonstrated to be expressed in various gastrointestinal carcinomas and also to play pivotal roles in the uptake of a wide variety of both endogenous and exogenous anionic compounds, including bile acids, conjugated steroids and hormones, into hepatocytes in the human liver. However, the biological significance of LST-2 in human carcinomas remains unknown. In the present study, we examined the expression of LST-2 in 102 cases of breast carcinoma using immunohistochemistry and correlated the findings with various clinicopathological parameters in order to examine the possible biological and clinical significance of LST-2. LST-2 immunoreactivity was detected in 51 cases (50.0%); of these 51 positive cases, LST-2 immunoreactivity was inversely correlated with tumor size (P=0.0289). In addition, LST-2 immunoreactivity was significantly associated with a decreased risk of recurrence and improved prognosis by both univariate (P=0.02 and P=0.01) and multivariate (P=0.03 and P=0.01) analyses. In the estrogen receptor-positive groups, the LST-2-positive patients showed good prognoses. Considering that LST-2 transports estrone-3-sulfate, these results suggest that LST-2 overexpression is associated with a hormone-dependent growth mechanism of the breast cancer. The results of or present study demonstrate that LST-2 immunoreactivity is a potent prognostic factor in human breast cancer.

  15. 核内受容体を介した胆汁酸・脂肪酸・エイコサノイドのクロストークと発癌機構への関与

    海野 倫明, 及川 昌也

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽研究

    Category: 萌芽研究

    Institution: 東北大学

    2005 - 2006

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    【背景】我々は,cDNAマイクロアレイ法を用いて各種肝胆道系細胞で胆汁酸により誘導される新規遺伝子として転写因子Snailを同定した.SnailはEpitherial-mesenchymal transition(EMT)のmaster regulatorの一つで,肝細胞癌において腫瘍の被膜浸潤の有無とSnailの発現に相関が認められることが報告されている.今回,胆汁酸のSnail誘導機序と細胞浸潤能の変化について検討した.【方法】ヒト肝細胞癌由来Hep3B使用した.Snail promoter領域を単離,Luciferase assayにてSnail転写活性化機構を検討した.In vitro wound healing assay, invasion assayにて細胞浸潤能の変化を測定した.【結果】胆汁酸添加にてmRNAレベルでSnailの誘導,E-cadherinが抑制されることが確認された.欠失変異体での検索では,Snail転写開始点より-111から-24bpに胆汁酸反応領域が存在することが示唆され,同部位に存在するnuclear factor Y(NF-Y),stimulating protein 1(Sp1)結合領域にmutationを入れることにより胆汁酸反応性の低下を認めた.胆汁酸添加により細胞移動能,浸潤能共は増加していた.さらに,Snail siRNAをtransfectionしSnailを抑制すると,胆汁酸添加によるE-cadherinの抑制は減少,細胞浸潤能の変化も消失した.【結論】胆汁酸がE-cadherinを抑制し細胞浸潤能を増加させることが明らかとされた.この過程にはSnailの誘導が必須であることが示唆された.

  16. Development of a cancer gene therapy based on circadian rhythm

    KAYAYOSE Yu, UNNO Michiaki, RIKIYAMA Toshiki, YAMAMOTO Kuniharu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2004 - 2006

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    The purpose : As for the receptivity of the cancer cell, to the tumor medicine, it is provided by the circadian rhythm, and the reduction of a high antitumor effect and the side effect is expected in matching the cell cycle to the time of the anti-cancer drug administering at the proliferative condition of the cancer cell and the cell cycle. This time, the research of gene therapy that used the clock gene was advanced, and it was assumed this conducting research to use it for clinical this time. Results : 1.To examine the circadian rhythm, the following serum shock oscillation was confirmed with real-time PCR by various cancer cells (AsPC-1,Panc-1). The wave of oscillation was not able to be confirmed, it was concluded the characteristic of stimulation or the characteristic of the cell stock, and used mainly AsPC-1 to research in panc-1 though the circadian rhythm of almost 24 hour was able to be confirmed in AsPC-1 as a result. 2.To confirm the effect of using together with various anti-cancer drug, the effect of using together with adenovirus pe2 was examined with CDDP, 5-FU, and gemicitabine, Taxoter, and CPT-11,etc. As a result, the synergy effect was admitted though the effect of using together of doing only to 5-FU and gemicitabine, Takisotal, and CPT-11 was not admitted though it was a little in CDDP. 3.The anti-cancer drug matched to the amplitude of hPer2 was exposed by having admitted the synergy effect of CDDP and mPer2 Adenoviralvecter, and the change in the anti-cancer drug receptivity of the cancer cell stock was examined according to the circadian rhythm. The result is rinse after 6hr is exposed and, as a result of assay four days later, 1). The appearance of hPer2 rises about CDDP, and the change is not in receptivity at bottom, and receptivity rises by the peak of hPer2. (Panc1, Aspc1). 2) It turned out that the inclination of the peak was larger about GEM though receptivity rose by both bottom and the peak of hPer2 compared with the control.

  17. Reg Gene and Reg receptor Expressed in Human Gastrointestinal Cancers

    UNNO Michiaki, KATAYOSE Yu, OKAMOTO Hiroshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: TOHOKU UNIVERSITY

    2002 - 2004

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    Reg (Regenerating gene) gene encodes a secretory protein that induces pancreatic beta-cell proliferation as an autocrine/paracrine growth factor via Reg receptor (RegR). Reg protein has been suggested to be involved in regenerative cell proliferation in many tissues such as gastrointestinal, neural and cardiovascular cells. Here, we found a novel human type III REG gene, REGIII. This gene is devided into six exons spanning about 3.0 kbp, and encodes a 175 amino acid protein with 85% homology wiht HIP/PAP. REG III was expressed predominantly in pancreas and testis but not in small intestine, whereas HIP/PAP was expressed strongly in pancreas and small intestine. Now, we established the immunohistochemical analyses for human REG I alfa, REG I beta, REG III, HIP/PAP, REG IV using specific monoclonal antibody. Now, we invetigate the expression of the member of the REG gene family on various gstrointestinal cancers including gastric cancer, colon cancer, pancreatic cancer, liver cancer, and bile duct cancer obtained from surgery. We constructed the database of surgical specimen, including tumor type, the serum level of tumor marker, histological stage, venous invasion, lymph node metastasis, type of recurrence, and prognosis. Though it is analyzing, it is possible that the expression of the member of REG gene family might be associated with the prognosis.

  18. 腸肝循環を担う新規ヒト有機アニオントランスポーター遺伝子の構造と機能の解明

    鈴木 正徳, 片寄 友, 阿部 高明, 海野 倫明

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2002 - 2003

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    1)ヒト小腸上皮cDNAライブラリーの作製 ヒト小腸、特に回盲部腸管上皮を手術標本より採取し、poly A RNAを抽出し、逆転写酵素を用いてcDNAを作製し、lambda ZAPIIベクターに組み込んだ、ヒト小腸上皮DNAライブラリーを作製した。現在ライブラリーを既知のcDNA、ヒトLST-1,LST-2をプローブとしてスクリーニングを行なっている途中である。ヒト腸管上皮の基底膜側にはOATP-Eが発現していることが明らかとなったが(後述)、apical側のナトリウム非依存性トランスポーターはいまだ不明であり、この新規トランスポーターの単離を継続する予定である。 2)ヒトOATP-Eの小腸における発現 ヒトOATP-Eは我々が単離した、胆汁酸・甲状腺ホルモンを輸送する新規有機アニオントランスポーターである。このOATP-Eは様々な臓器で発現していることが知られていたが、腸管の上皮細胞での発現はこれまで明らかにされていなかった。我々はこのOATP-Eに対する抗体を作製しウエスタンブロット、免疫染色を行なった。ウエスタンブロットでは約55kDaの単一バンドとして腸管上皮での発現が確認された。また免疫組織化学法を施行し消化管上皮での細胞内局在を検討したところ、回腸末端粘膜上皮細胞の基底膜上に強い発現が見られた。極性をもつヒト大腸癌由来細胞株Caco-2を用いて同様に免疫組織学的検討を行うと、細胞膜にOATP-Eの発現が見られ、CD13とは共存しないことよりapical側ではなくbasolateral側に局在すると考えられた。以上の結果よりOATP-Eは腸管上皮細胞の基底膜側に局在し、apical側のトランスポーターにより細胞内に輸送された胆汁酸や甲状腺ホルモンを基底膜側から細胞外へと輸送する機能を有していると考えられ、胆汁酸や甲状腺ホルモンの腸肝循環に関与するトランスポーターであることが明らかとなった。

  19. Molecular characterization of the organic anion transporter family

    ABE Takaaki, UNNO Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2002 - 2003

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    One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing while the low concentration in normal human cells decreases side effects. We have isolated the organic anion transporter OATP/LST family which exclusively expressed in various gastrointestinal cancers. We have established LST-1 and LST-2 recombinant adenoviruses, termed AdLST-1 and AdLST-2. In vivo effects of the combination of MTX with the adenoviruses were estimated in a subcutaneous tumor model using SCID mice. Tumors treated with AdLST-1/MTX or AdLST-2/MTX grew more slowly than those treated with Adβ-gal/MTX. Whole-body autoradiographs confirmed that incorporation of [^3H]-MTX in tumors of mice treated with AdLST-1/MTX and AdLST2/MTX. Our observations strongly support the possibility that overexpression of influx pumps is a new avenue in the enhancement of cancer chemotherapy.

  20. Chrono-biological genetherapy for bile duct cancer

    KATAYOSE Yu, UNNO Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: TOHOKU UNIVERSITY

    2002 - 2003

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    The susceptibility of the cancer cell to anti-neoplasm medicine is prescribed by the multiplication state of a cancer cell, and the cell cycle, it is uniting the cell cycle of a cancer cell, and the timing of medicine medication, and cancer medical treatment with few side effects is expected. Research of a clock gene is progressing recently, molecular biology-examination of each clock gene is progressing, per1, per2, cry1 and cry2, BMAL-1, etc. attract attention as main clock genes, and it is said that per2 is closely related with carcinogenesis. Existence of the clock gene in various cancer cells was checked centering on the PAS domain and CKI domain of per2 considered to be first the most important as a result in this research period. The cell lines examined bile duct cancer cells, TFK-1, the HuCCT1, liver cancer cell, HepG2, Hep3B, HT-17,Li-7,HuH-7,PLC/PR/5, breast cancer cells, MCF-7, and MDA-MB-231, and checked existence of per2 by RT-PCR and the sequence. On the other hand, preparing the adenoviral vector for genetherapy, Adenovirus expressing CDK inhibitor p27 was used for check efficiency of transduction for cholangiocarcinoma. CDK inhibitor p27 is closely related with clock gene as a control of cell cycle. The cell cycle stopped and induced apotosis to cholangiocarcinoma,TFK-1, using. Adp27. This result can expect the effect of the gene therapy by the clock gene.

  21. New Frontiers of Bile Acid Research -Act as a Transcriptional factor for Liver and Gastrointestinal cancers-

    MATSUNO Seiki, KATAYOSE Yu, ABE Takaaki, UNNO Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2001 - 2003

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    The basolateral membrane of the hepatocyte is characterized by various transporters, one of which is responsible for cellular uptake of organic anionic substances, including bile acids, steroids and certain drugs from the blood. We have isolated human liver-specific organic anion transporter, LST-2 (SLC21A8, OATP8), which is exclusively expressed in the basolateral membrane of the hepatocyte. We demonstrated that LST-2 transports chenodeoxycholate, which is a ligand for the farnesoid X receptor (FXR). In this study, we analyzed the transcriptional regulation of the LST-2 gene in hepatocyte-derived cells. We also examined the effect of bile acid on LBT-2 gene transcription. The promoter activity of the 5'-upstream region of the LST-2 gene was analyzed by luciferase reporter gene assay. Deletion analysis showed that the 5'-flanking region from -180 to -20 bp is responsible for LST-2 transcriptional activity. By site-directed mutation analysis, it was revealed that the consensus binding sites for FXR, HNF1a, and HNF3b play important roles in the transcriptional activity of the LST-2 gene. By electrophoresis mobility shift assay, we observed specific protein-DNA complexes of FXR, HRF1a, and HNF3b. Luciferase activity was increased 5-fold when chenodeoxycholate or deoxycholate were added but was not increased using the vector mutated at the FXR binding site. Western blot and northern blot analyses revealed that the expression of LST-2 was increased by addition of chenodeoxycholate or deoxycholate were in a dose-dependent manner. In conclusion, our findings suggest that HNF1a and HNF3b might contribute to liver-specific expression and FXR might play a role in transcriptional activation by chenodeoxycholate and deoxycholate.

  22. Identification of organic anion transporter LST-2 which expressed in the gastrointestinal cancers: clinical implication for anticancer drug delivery.

    ABE Takaaki, HARADA Shizuko, UNNO Michiaki, YAMORI Takao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2001 - 2002

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    Background & Aims: One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing while the low concentration in normal human cells decreases side effects. The aim of this study is to isolate an organic anion transporter which in weakly in normal, but abundantly expressed in cancer cells, to deliver the anti-cancer drugs to the cells. Methods: A human liver cDNA library was screened with LST-1 cDNA as a probe, Northern blot analyses were performed using the isolated cDNA (termed LST-2). A LST-2 specific antibody was raised and immunohistochemical analyses including immuno-electron microscopy were performed. Xenopus oocyte expression system was used for functional analysis. We also established a permanent cell line which consistently expresses LST-2 to examine the relationship between MTX uptake and sensitivity. Results: The isolated cDNA, LST-2 has 79,7 % of overall homology wish human LST-1. LST-2 exclusively expressed in the liver under normal conditions and immunoreactivity was highest at the basolateral membrane of the hepatocytes around the central vein. Although its weak expression in the liver, LST-2 is abundantly expressed in the gastric, colon and pancreatic cancers, On she other hand, she LST-1 was only detected in a hepatic cell line, LST-2 transports methotrexate in a saturable and dose dependent manner Furthermore, introduction of the LST-2 gene into mammalian cells potentiates sensitivity to methotrexate. Conclusion: LST-2 is one of the prime candidate molecule for determining methotrexate sensitivity and may be a good target on deliver anti-cancer drugs to the gastrointestinal cancers.

  23. 時計遺伝子を用いた時間生物学的がん遺伝子治療

    片寄 友, 海野 倫明, 鈴木 正徳

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽的研究

    Category: 萌芽的研究

    Institution: 東北大学

    2001 - 2001

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    抗腫瘍薬に対する癌細胞の感受性は、癌細胞の増殖状態、細胞周期により規定されており、癌細胞の細胞周期と薬剤投与のタイミングを合わせることで、副作用の少ない癌治療が期待されている。特に細胞分裂の中でDNA合成期、分裂期が薬剤に対する感受性が高いとされており、この時期の癌細胞に、あるいは正常細胞が休止期にタイミング良く薬剤を投与することが肝要である。しかし、癌細胞はheterogeneityが強く各癌細胞は一律に同期しておらず、サーカディアンリズムに合わせて薬剤を投与しても、効果が不充分なことが多い。そこで、時計遺伝子により癌細胞を調律し、さらに体内に生理的に存在する時計遺伝子蛋白により目的遺伝子発現をコントロールし、抗腫瘍効果の向上、副作用の低減を図り癌細胞に時計遺伝子産物により発現するベクターを構築し、生体リズムに合わせた遺伝子治療の可能性を探ることが最終的な目的である。 本年度は時計遺伝子およびプロモーター領域の単離およびサブクローニングを行い、発現ベクターを作製することを主な目的としており、発現ベクターの解析を行った。

  24. Transcriptional Regulation of Liver-specific Organic Anion Transporters and Those Clinical Application

    UNNO Michiaki, ABE Takaaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: TOHOKU UNIVERSITY

    2000 - 2001

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    In 1999, we have cloned a novel human organic anion transporter named LST-1. LST-1 is strongly expressed in liver and its substrates are bile acid, conjugated steroids, eicosanoids, and some kinds of drugs. Immunohistochemical analysis indicated that LST-1 was located at sinusoidal membrane of the hepatocytes. The aim of this study is to investigate the transcriptions]-regulation mechanism of human LST-1 gene and its clinical application. The results are follows; 1. Luciferase assay using HT-17 cell lines derived from hepatocyte revealed that AP-1 site (-1100bp upstream from transcriptional starting site) and HNF-1 site (-60bp) were considered to be important region for transcription. 2. Luciferase activity was decreased in the reporter plasmid which inserted point mutation in the HNF-1 binding site. 3. Electrophoresis mobility shift assay (EMSA) using nuclear extract of HT17 revealed that specific protein-DNA complex was detected using oligonucleotide (from-78 to -48). 4. Supershift band was observed by adding a HNF-1 a antibody. These results indicated that transcriptional factor, HNF-1 a was combined with about -60bp of LST-1 gene upstream and was considered to be most important by transcription of the LST-1 gene in hepatocytes.

  25. アポトーシスにおけるp27^<kip1>の分解制御と細胞死シグナルの相互作用の探究

    海野 倫明, 鈴木 正徳, 片寄 友

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特定領域研究(C)

    Category: 特定領域研究(C)

    Institution: 東北大学

    2000 - 2000

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    我々はCDK inhibitorの1つであるp27/kip1を発現したアデノウイルス(以下Adp27)が,各種腫瘍細胞培養株に対してapoptosisを誘導することを報告し,p27/kip1が癌抑制遺伝子類似の機能を有することを提唱してきたが,そのメカニズムは不明のままであった.平成12年度の研究成果として,p27/kip1によるapoptosis誘導のメカニズムの一端をFas/Fas ligand systemの面から解析した. (1)Adp27感染72時間後にTUNEL assayを施行した結果,対象群に対して明らかな右方シフトを示し,Adp27感染によるapoptosis誘導を確認した. (2)Adp27感染前では胆管癌細胞表面にFas発現を認めたがFas ligand発現は認めなかった.一方,p27感染48時間後では明らかなFas ligandの発現を認め,Adp27によるapoptosis誘導にFas pathwayが関与することが示唆された。 (3)コントロールとしてp27と同じCDK inhibitorであるp21をアデノウイルスを用いて細胞内に導入し,同様にフローサイトメトリーにてFas ligandの細胞表面への発現を確認したが,Adp21感染後にはFas ligandの発現は全く認められなかった. (4)Fas ligandの中和抗体であるNOK1を添加しTUNEL assayを施行した.Adp27感染後の添加でもapoptosisがほぼ完全に抑制され,p27/kip1によって誘導されるapoptosisがFas/Fas ligand systemを主要経路とすることが確認された. (5)Western blot,RT-PCRでFas ligand発現誘導を確認したが,Adp27感染後もde novoとしてのFas ligandタンパクやFasL mRNA発現量に変化は認められなかった. 以上より,p27/kip1によるアポトーシス誘導にFas/Fas ligand systemが深く関与していることが明らかとなった.p27/kip1によるFas ligandの細胞表面の発現はde novo Fas ligandの誘導を伴わず,その局在を細胞内から表面へ変化させることでアポトーシスのトリガーとしている可能性が示唆された。

  26. 遺伝子変異に捕われない細胞死シグナル賦活を標的としたp27^<kip1>遺伝子治療

    片寄 友, 海野 倫明, 鈴木 正徳

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特定領域研究(C)

    Category: 特定領域研究(C)

    Institution: 東北大学

    2000 - 2000

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    はじめに:我々の治療の中心である胆管癌症例は浸潤性が高く、特に脈管、神経周囲浸潤が高率で、根治手術が困難であり(鈴木らCancer64,658-666,1989)、予後およびQOLの改善のため放射線治療を含めた集学的治療を施行してきた。しかし、癌の根絶を図り治癒させるためには、腫瘍特異性があり、抗腫瘍活性の高い治療法の開発が不可欠であると考えられている。昨今の分子生物学的手法が急速に進歩し、遺伝子治療が我が国でも試みられてきている。われわれはcyclin dependent-kinase inhibitor p27^<kip1>を組込んだアデノウイルス(Adp27)を用いて、乳癌細胞株を用いてAdp27がp53の状況に関係無くアポトーシスを誘導できることを証明した。 そこで、p27^<kip1>を用いた遺伝子治療により、遺伝子に捕らわれない広く応用できる治療をの開発を目指した。 研究実績概要:われわれは、アデノウイルスp27(Adp27)が各種細胞株に対してアポトーシスを誘導する際、フローサイトメトリー(FACS)を用いてFas ligand(FasL)が細胞表面に発現することを既に証明しており、Fas経路がAdp27のアポトーシスの一つの経路と考えている。そこで、本年度は、Adp27がアポトーシスを誘導する際のFasLの発現メカニズムを解明すると共に、Fas経路がAdp27のアポトーシスに関与する度合いを検討した。その結果、TFK-1に於いてFasLの中和抗体によりアポトーシスがほぼ完全に抑制されたことにより、Adp27のアポトーシスがFas経路を主に用いることがわかり、またFasLはWestern blot法あるいはRT-PCR法に於いても発現は認められず、転写に依存しない機構で、FasLの細胞表面への発現がコントロールされていることが明かとなった。

  27. New transcatheter arterial embolization therapy for unresectable hepatocellular carcinoma using ferromagnetic iron-dextran reagents combined with anticancer drug and bispecific antibody

    SUZUKI Masanori, KATAYOSE Yu, ENDO Kojin, UNNO Michiaki, OSADA Yukihiro, MIURA Shigeto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    1999 - 2000

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    With the aim to see the fate of unresectable tumor of the liver, we are planning to embolize the tumor feeding artery via transcatheteric route by novel embolus, ferromagnetic iron-dextran along with Reveromycine (RM) - A, which is a mitogenic inhibitor and bispecific antibody targeting for both hepatoma cells and LAK cells. This complex forms a colloid which will held at tumor site by creating a magnetic field around the tumor site. For the component of novel transcatheteric hepatic arterial embolus, we synthesized two kinds of bispecific antibodies (BsAbs), i.e., (OKXL) BsAbs constructed with both OKT-3 (anti-CD3) and L-7-6 (anti-HCC), and (3GXL) BsAbs constructed with 3-G-8 (anti-CD-16) and L-7-6 antibodies by chemical reconstruction method. The cytotoxicity was tested by MTT assay in several conditions. These two BsAbs, having pairs of binding arms on their single molecule, showed similar binding to target cells as the parental monoclonal antibodies (OKT-3, 3-G-8, L-7-6), when examined with FACS. Newly devised in vitrocytotoxicity tests revealed that LAK or PWM-simulated LAK (PWM-LAK) cells did not show any significant cytotoxic activity to HCC cells, while both effector/target (0.3) in the presence of BsAbs (OKXL) for the efficient retargeting of the effector cells. Inasmuch as PWM-LAK cells proliferate in vitro 3-5 times faster than LAK cells, adoptive immunotherapy using PWM-LAK cells in combination with (OKXL) BsAbs should be very promising.

  28. Proposal and Development of "re-construction artificial liver" using liver-specific organic anion transporter.

    MICHIAKI Unno, ABE Takaaki, SUZUKI Masanori, ENDO Koujin, KATAYOSE Yu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: TOHOKU UNIVERSITY

    1999 - 2000

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    The uptake of various compounds from the circulation is one of the most important functions of hepatocytes. Because of its wide substrate specificity and abundant expression in the liver, human liver-specific organic anion transporter-1 (LST-1) and its subtype LST-2 play important roles in liver function. Both LST-1 and LST-2 are only expressed in liver and its substrates are bile acid, conjugated steroids, eicosanoids, and some kinds of drugs. The aim of this study was to introduce LST-1 and LST-2 recombinant adenovirus into mammalian cells to analyze the function of LST-1 and LST-2 in details. The results are follows; 1. LST-1 and LST-2 cDNA recombinant adenoviruses, termed AdLST-1 and AdLST-2, were constructed by Adenovirus Expression Vector Kit (TaKaRa BIOMEDICALS, Tokyo, Japan). 2. Western blot analysis showed the LST-1 and LST-2 were strongly expressed in HepG2 infected AdLST-1 and AdLST-2. Confocal laser scanning microscopy revealed that LST-1 or LST-2 immunoreactivity was mostly localized at cell membrane, and weakly in the cytosol. 3. Uptake study indicated that LST-1 and LST-2 could transport taurocholate, prostaglandines, methotrexate, dehydroepiandrosterone sulfate, and thyroid hormones. Significant uptake of chenodeoxycholate (CDCA) was detected in LST-2-expressing cell but CDCA transport by LST-1 was not detected. Our overexpression system using LST-1 or LST-2 recombinant adenovirus can add the liver-specific function of uptaking its specific compounds to the cancer cell line like as HepG2 which has no expression of LST-1 and LST-2.

  29. 臍帯血ファージライブラリーを応用した各種癌抗原に対するヒト抗体作製法の開発〜癌特異的抗体免疫療法への応用をめざして〜

    鈴木 正徳, 片寄 友, 海野 倫明

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 萌芽的研究

    Category: 萌芽的研究

    Institution: 東北大学

    1999 - 2000

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    最近の遺伝子工学界の話題として、小動物の血液から取り出したcDNAライブラリーからPCR法にて増幅させた可変領域のライブラリーを作製して、それを一本鎖抗体の形でファージに組み込んだファージライブラリーの応用があげられる。ファージライブラリーを用いたファージ提示法とは、様々なポリペプチドが繊維状ファージのコートタンパク上に融合タンパク質として提示される技術である。ランダム化した巨大な遺伝子ライブラリーから、迅速かつ効率的に目的分子に対して高い結合活性を持つ配列を選択できることから、このファージ提示法はライブラリーからの選択において実に有用である。 今回は、腫瘍に対する特異性の高い抗体免疫療法に使用する、各種癌抗原に対応するヒト抗体の作製をおこなった。外界に対する免疫の少ないヒト臍帯血から、潜在的に保有されている抗体の可変領域の遺伝子ライブラリーを作製し、これを一本鎖抗体の形でファージ表面に提示して、ELISAプレートに固相化した抗原を用いてパニングを行い、抗原に強く反応するファージを選択した。この選択した可変領域の遺伝子を利用して一本鎖抗体またはFv断片の形で作製した。すなわちMUC1エピトープをELISAプレートに固相化して、ペプチドと結合していたファージを回収した。選択されたファージをLBプレートにまいて、出現するシングルコロニーに対応するファージも調製して、ELISA反応を行った。発色の強いファージに対応するファージミドベクターにSequencingを行い、可変領域の塩基配列を調べた。同時に、一本鎖抗体の遺伝子を大腸菌で分泌発現させた。分泌発現した一本鎖抗体はIMACにて精製を行い、さらにゲル濾過にて単一に分離精製をこころみた。抗His tag抗体を用いたWestern blottingにてその発現を確認した。我々の樹立した肝外胆管癌細胞株TFK-1は高頻度にMUC1を発現している。この細胞株を用いて、Flowcytometryにて抗His tag抗体で結合能を測定した。

  30. Establishment of the adoptive anticancer immunotherapy for the unresectable cholangiocarcinoma using the bispecific antibody - Construction of bacterial expression system of bispecific antibodies

    SUZUKI Masanori, KUMAGAI Izumi, ENDO Kojin, UNNO Michiaki, TSUMOTO Kohei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: TOHOKU UNIVERSITY

    1997 - 1999

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    In order to construct the stabel supply system and apply to the immunotherapy for unresectable cholangiocarcinoma, the bacterial expression system of variable regions of anti-MUC-1 IgG, anti-CD3 IgG and anti-CD28 IgG derived from original hybridoma cell line was constructed. Each cDNA encoding corresponding variable region of immunoglobulin was cloned, followed by linking the regions with flexible peptide linker (GlyGlyGlyGlySer)3. The genes encoding single chain Fv fragment were arranged with either VH-linker-VL or VL-linker-VH. The expressed insoluble proteins were solubillized by Guanidine-HCl, refolded, and purified by metal-chelating chematography. Prepared MUSE-11, anti-CD28 and anti-CD3 scFv had same specificity for each original IgG. And a bispecific diabody binding to adenocarcinoma associated antigen MUC1 and to CD3 on Tcells has been focused. Namely, one chain consisted of a VH specific for MUC1 linked to a VL specific for CD3 with a short polypeptide linker (GGGGS). They second was composed of the VL specific for MUC1 linked to the VH specific for CD3. The two hetero sc Fvs were independently obtained from intracellular insoluble fractions of E. coli, purified and mixed stoichiometrically and refolded by the modified dialysis method. The refolded two hetero scFv has hetero-dimeric structure, with distinct specificity for both target cells. Evaluation of the in vitro efficacy of T-LAK with the diabody by growth inhibition assay of cancer cells demonstrated maximum growth inhibition of cancer cells to reach about 98% at the effector:target ratio of 10, almost identical to that with anti-MUC1 x anti-CD3 chemically synthesized BsAbs. Bispecific diabody may be good candidates for new adoptive targeted immunotherapy.

  31. 新たに同定した肝特異的ホスホイノシチド3-キナーゼ〜肝癌発生と進展への関与〜

    竹内 丙午, 遠藤 公人, 大和田 祐二, 海野 倫明, 鈴木 正徳

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    1998 - 1998

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    われわれがラットにおいてクローニングした新しいホスホイノシチド3-キナーゼ(PI3K-IIγ)の発現が,臓器特異的に肝に集中しており,また,PI3Kは細胞増殖に関与することが知られていた.そこで,肝細胞癌を研究対象に,PI3K-IIγの癌化機構への関わりを検討する研究を立案し,平成10年4月より実験的研究を開始した. まず,われわれの持つラットPI3K-IIγのcDNA塩基配列よりプライマーを設計し,ヒト型PI3K-IIγのcDNAクローニングに着手した.プライマーは,nest-PCR施行のため4種類作成し,LA-Taq酵素を用いて,ヒトPI3K-IIγの翻訳領域のうち,約1000塩基対のcDNAクローニングに成功した.このcDNAのシークエンス分析を行うとともに,これをプローブとしてヒトcDNAライブラリーをスクリーニングし,非翻訳領域を含めた全長のcDNAの同定に成功した. 続いて,ヒトPI3K-IIγのN-およびC-末端側から,ほかのPI3Kアイソザイムと類似性低い部分のアミノ酸配列,各々20アミノ酸を選び,そのcDNAを発現ベクターに組み込み大腸菌で発現させた.この際に,発現させるペプチドのN末側にGSTを付加するような発現ベクターを用い,ペプチド回収にはGST結合カラムを用いた。このペプチドをウサギに免疫するよう保存した。 この作業と平行して,ヒト肝細胞株(HepG2,HT-17など計5種)を培養し,それらのRNAを抽出してNorthern Blot法によるPI3K-IIγ遺伝子発現の解析を行った。はじめtotal RNAを用いて解析したところ発現が認められなかったため,poly(A)+RNAの精製まで行っている。

  32. SEA-scFv as bifunctional antibody : Construction of the bacterial expresion system and its function

    SUZUKI Masanori, ENDO Kojin, UNNO Michiaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    1997 - 1998

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    A SEA-antibody single chain Fv (SEA-scFv) fusion protein was produced byu bacterial expression system in this study. SEA-scFv has both staphylococcal enterotoxin A(SEA) effects and antibody activity directed at the epithelial mucin core protein MUCl, a cancer associated antigen. It was expressed mostly in the cytoplasm as an insoluble form. The gene product was solubilized by guanidine hydrochloride, refolded by conventional dilution method, and purified using metal-chelating chromatography. The resulting SEA-scFv fusion protein preparation was found to react with MUC1 and MHC class II antigens and had the ability to enhance cytotoxicity of lymphokine activated killer cells with a T cell phenotype against a human bile duct carcinoma cell line, TFK- 1, expressing MUC1. This genetically engineered SEA-scFv fusion protein promises to be an important reagent for cancer immunotherapy.

  33. 腹膜炎時の肝障害におけるヘムオキシゲナーゼの発現誘導と一酸化炭素の関与

    海野 倫明

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 奨励研究(A)

    Category: 奨励研究(A)

    Institution: 東北大学

    1997 - 1998

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    1. 腹膜炎モデルラットをcecum ligation and pnctureの方法で作製し,これらラットに,Hemeoxygenaseのinhibitorである,Sn protoporphyrin-9(Sn-PP),あるいはZn protoporphyrin-9(Zn-PP)を各種濃度でCLP施行18時間前,および施行直後に腹腔内注射を施行し,血清中AST・ALT・LDH値を測定し,もっとも肝細胞障害を抑制した濃度を決定した。その結果,約0.5μmol/kg body weightから5μmol/kg body weightの濃度のSn-PPが,また,5μmol/kgbody weightの濃度のZn-PPがAST・ALTの上昇を有意に抑制していた。 2. cyclic GMPをELISA法により測定した。対照群では前値が11.42±1.18pmol/g・tissueであったcyclic GMPは24時間後には15.37±3.02 pmol/g・tissueへと増加していたが,Sn-PPまたはZn-PPの投与により,それぞれ7.24±1.16pmol/g・tissue(5μmol/kg body weight),5.68±1.37pmol/g・tissue(10μmol/kg body weight)に有意に低下した。 3. これらの肝臓を摘出し,光顕用標本を作製し,point counting methodにて肝類洞腔容積比を算出した。対照群ではCLP前(0.086±0.006)から(0.140±0.0.10)へと約1.6倍に増大していた。一方,Sn-PP投与群では5μmol/kg body weightで(0.103±0.011),10μmol/kgbody weightで(0.0.94±0.009)と,有意に肝類洞の拡張が抑制されていた。以上の結果より,Heme oxygenase阻害剤は,cyclic GMPを有意に抑制し,これにより肝類洞腔の拡張が抑制されていることが考えられ,これが肝細胞障害の抑制に関与している可能性が示唆された。

  34. 肝癌を標的とした抗癌剤・バイスペシフィク抗体磁性複合体の磁界にによる肝内分布制御

    鈴木 正徳, 三浦 成人, 長田 裕之, 海野 倫明

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    1997 - 1997

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    本研究課題の円滑な実行を目的とした共同研究組織との数次にわたる会議により、本研究に使用する磁性体を栄研化学が開発した製剤を使用することとした。栄研化学は、全世界に先駆けて超常磁性酸化鉄コロイドを作製し、平成9年7月から厚生省から薬事認可を得てフェリデックスとして市販を開始した。本製剤は磁場をかけたときに強磁性を示し、磁場を外すと磁性が0に戻る性質を有しており、磁気共鳴映像における組織分解能を上昇させる増感剤として臨床応用されている。その性状は50Aの酸化鉄をコアに、表面をデキストランからなる多糖類で被覆した平均粒子径約50〜40nmの磁性体であり、主にオプソニン効果による貪食作用によりKupffer細胞に取り込まれる。また、同社はフェリデックスの開発過程でコアとなる酸化鉄のサイズを自由に、かつ均一に製造する技術を確立し、さらに各種の被覆剤に関する研究も進行中で、たとえば肝細胞膜表面に存在するアシアロ糖蛋白受容体に特異的に結合するアラビノガラクタン被覆の超常磁性酸化鉄コロイドの作製も可能な状況にある。実際の研究では、塞栓物質として、今までのTAEの概念からはかけ離れた特異な磁性体コロイドを用いることとし、その外套を形成する合成糖蛋白からなる被覆剤に、われわれが研究を維持してきた肝細胞癌に対するBsAbと、理化学研究所抗生物質研究室で開発されたリベロマイシンA(以下RM-A)などの抗腫瘍剤を吸着させて、強磁性体を取り込んだ抗癌物質を作製し、体外からの磁場形成により肝臓内における最適な磁性薬剤分布を自由に形成することを目指す。磁界生成には、比較的簡便な永久磁石によるものと超伝導マグネットを考慮している。後者には、最近実用化され始めた液体ヘリウムを使用しない冷凍機直冷型超伝導マグネットがあり、従来型に比し遙か小型でグネットの方向変更も容易であり、数Teslaのスプリット型マグネットの製作も可能なことから有用と考えている。

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Social Activities 4

  1. [日本国内] PanCan JAPAN

    2010/04/01 - Present

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    膵癌患者団体

  2. [日本国内] 消化器病学会市民公開講座

    2009/09/26 -

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    座長

  3. [日本国内] 第2回東北大学市民公開講座

    2009/06/28 -

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    講演

  4. [日本国内] 全国肝胆膵外科手術ランキング

    2008/01/10 -

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    全国の肝胆膵外科手術件数が全国11位

Media Coverage 3

  1. [日本国内] なるほど健康雑学ー東北大学リレー講座「転移性肝癌」

    河北新報

    2008/11/17

    Type: Newspaper, magazine

  2. [日本国内] なるほど健康雑学ー東北大学リレー講座「胆道癌」

    河北新報

    2008/11/10

    Type: Newspaper, magazine

  3. [日本国内] なるほど健康雑学ー東北大学リレー講座「膵癌」

    河北新報

    2008/11/03

    Type: Newspaper, magazine

Other 1

  1. 肝内結石症班会議

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    肝内結石症に関する研究