Details of the Researcher

PHOTO

Islam Jahidul
Section
Graduate School of Agricultural Science
Job title
Associate Professor
Degree

Research Areas 1

  • Life sciences / Immunology /

Papers 21

  1. Breast milk stabilizes bacterial communities in the large intestine even after weaning

    Kaori Ito, Jahidul Islam, Kota Sakurai, Saeka Koyama, Ayumi Matsuo, Kunihiro Okano, Ryota Hirakawa, Mutsumi Furukawa, Tomonori Nochi

    Biochemical and Biophysical Research Communications　151585-151585　2025/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbrc.2025.151585 　

    ISSN： 0006-291X

  2. Freeze-dried fecal microorganisms as an effective biomaterial for the treatment of calves suffering from diarrhea

    Jahidul Islam, Natsuki Ohtani, Yu Shimizu, Masae Tanimizu, Yoshiaki Goto, Masumi Sato, Eiji Makino, Toru Shimada, Chise Ueda, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Niel A. Karrow, Hiroshi Yoneyama, Ryota Hirakawa, Mutsumi Furukawa, Hidekazu Tanaka, Tomonori Nochi

    Scientific Reports　14　(1)　2024/11/14

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-79267-5 　

    eISSN： 2045-2322

  3. Formation of the junctions between lymph follicles in the Peyer's patches even before postweaning activation

    Anri Teshigahara, Yuri Banba, Hiromi Yoshida, Mitsuji Kaji, Zhou Zhou, Nao Koyama, Yoshifumi Sakai, Niel A. Karrow, Kouetsu Ogasawara, Ryota Hirakawa, Jahidul Islam, Mutsumi Furukawa, Tomonori Nochi

    Scientific Reports　14　(1)　2024/07/09

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-65984-4 　

    eISSN： 2045-2322

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    Abstract Peyer’s patches (PPs), which contain an abundance of B and T cells, play a key role in inducing pivotal immune responses in the intestinal tract. PPs are defined as aggregated lymph follicles, which consist of multiple lymph follicles (LFs) that may interact with each other in a synergistic manner. LFs are thought to be spherical in shape; however, the characteristics of their structure are not fully understood. To elucidate changes in the structure of PPs as individuals grow, we generated serial 2D sections from entire PPs harvested from mice at 2, 4, and 10 weeks of age and performed a 3D analysis using a software, Amira. Although the number of LFs in PPs was not changed throughout the experiment, the volume and surface area of LFs increased significantly, indicating that LFs in PPs develop continuously by recruiting immune cells, even after weaning. In response to the dramatic changes in the intestinal environment after weaning, the development of germinal centers (GCs) in LFs was observed at 4 and 10 weeks (but not 2 weeks) of age. In addition, GCs gradually began to form away from the center of LFs and close to the muscle layer where export lymphatic vessels develop. Importantly, each LF was joined to the adjacent LF; this feature was observed even in preweaning nonactivated PPs. These results suggest that PPs may have a unique organization and structure that enhance immune functions, allowing cells in LFs to have free access to adjacent LFs and egress smoothly from PPs to the periphery upon stimulation after weaning.

  4. Broad specificity of monoclonal IgA (TEPC15-IgA) for enteric bacteria via phosphorylcholine-mediated interaction.

    Saeka Koyama, Kaori Ito, Katsuki Usami, Shino Wada, Tsukasa Yamashita, Wakako Ikeda-Ohtsubo, Haruki Kitazawa, Ryota Hirakawa, Jahidul Islam, Mutsumi Furukawa, Tomonori Nochi

    The Journal of veterinary medical science　2024/06/04

    DOI： 10.1292/jvms.23-0441 　

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    Immunoglobulin A (IgA) is notable for its broad specificity toward multiple bacteria. Phosphorylcholine (PC) plays a role in the infection of pathogenic bacteria carrying PC and in the induction of IgA responses in the host immune system. The commercially available mouse monoclonal IgA, TEPC15-IgA, is a distinctive antibody with specificity for PC, warranting further exploration of its response to PC-bearing enteric bacteria. In this study, using 17 different enteric bacteria, including 3 aerobic and 14 anerobic bacteria that could be cultured in vitro, we confirmed that TEPC15-IgA recognizes 4 bacterial species: Lactobacillus taiwanensis, Limosilactobacillus frumenti, Streptococcus infantis, and Escherichia coli, although reactivity varied. Interestingly, TEPC15-IgA did not react with four of six Lactobacillus species used. Moreover, distinct target molecules associated with PC in L. taiwanensis and L. frumenti were evident, differing in molecular weight. These findings suggest that the natural generation of PC-specific IgA could prevent PC-mediated infections and potentially facilitate the formation of a microflora rich in indigenous bacteria with PC, particularly in the gastrointestinal tract.

  5. The impact of high-IgE levels on metabolome and microbiome in experimental allergic enteritis

    Elisa Zubeldia-Varela, Frank Blanco-Pérez , Tomás Clive Barker-Tejeda, David Rojo, Alma Villaseñor, Jahidul Islam, Irene Gonzalez-Menendez, Jonathan Laiño, Maren Krause, Hanna Steigerwald, Manuela Martella, Leticia Quintanilla-Martinez, Philipp Yu, Coral Barbas, Stefan Vieths, Tomonori Nochi, Domingo Barber, Masako Toda, Marina Pérez-Gordo

    2024/06

    DOI： 10.1111/all.16202 　

  6. Identification of four genes responsible for antimicrobial resistance of MEL-B against S. aureus

    Shinya Yamauchi, So Shimoda, Akio Kawahara, Tomohiro Sugahara, Shuhei Yamamoto, Masao Kitabayashi, Atsushi Sogabe, Christine A. Jansen, Ryuta Tobe, Ryota Hirakawa, Jahidul Islam, Mutsumi Furukawa, Hiroshi Yoneyama, Tomonori Nochi

    Biochemical and Biophysical Research Communications　149566-149566　2024/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbrc.2024.149566 　

    ISSN： 0006-291X

  7. Effects of early-life tosufloxacin tosilate hydrate administration on growth rate, neurobehavior, and gut microbiota at adulthood in male mice.

    Ayano Hasegawa, Takahiro Sasaki, Jahidul Islam, Takashi Tominaga, Tomonori Nochi, Kenshiro Hara, Kentaro Tanemura

    The Journal of toxicological sciences　48　(3)　149-159　2023

    DOI： 10.2131/jts.48.149 　

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    Reportedly, antibiotics, which are frequently prescribed in children, have long-term effects owing to gut microbiota dysregulation. Tosufloxacin tosilate hydrate (TFLX) is the first orally administered new quinolone with high efficacy and broad-spectrum action approved as an antibacterial agent for pediatric use in Japan. However, studies on the effects of its early-stage administration are limited. Therefore, we aimed to analyze the later effects of its developmental administration by monitoring growth rate, neurobehavior, and gut microbiota in mice. The TFLX was administered via drinking water at a dose of up to 300 mg/kg for two consecutive weeks during the developmental period (4-6 weeks of age) or adulthood (8-10 weeks of age). Thereafter, the body weights of the mice were measured weekly to monitor growth rate. Behavioral tests were also conducted on 11-12-week-old mice to examine the neurobehavioral effects of the treatment. Further, to examine the effects of the treatment on microbiota, fecal samples were collected from the rectum of mice dissected at 12 weeks of age, and 16s rRNA analysis was conducted. Our results showed increased body weights after TFLX administration, without any long-term effects. Behavioral analysis suggested alterations in anxiety-like behaviors and memory recall dysregulation, and gut microbiota analysis revealed significant differences in bacterial composition. These findings indicated that TFLX administration during the developmental period affects mice growth rate, neurobehavior, and gut microbiota structure. This is the first study to report that TFLX is potentially associated with the risk of long effects.

  8. Development of a rational framework for the therapeutic efficacy of fecal microbiota transplantation for calf diarrhea treatment

    Jahidul Islam, Masae Tanimizu, Yu Shimizu, Yoshiaki Goto, Natsuki Ohtani, Kentaro Sugiyama, Eriko Tatezaki, Masumi Sato, Eiji Makino, Toru Shimada, Chise Ueda, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Mutsumi Furukawa, Katsuki Usami, Hiroshi Yoneyama, Hisashi Aso, Hidekazu Tanaka, Tomonori Nochi

    Microbiome　10　(1)　2022/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s40168-021-01217-4 　

    eISSN： 2049-2618

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    <title>Abstract</title><sec> <title>Background</title> Establishing fecal microbiota transplantation (FMT) to prevent multifactorial diarrhea in calves is challenging because of the differences in farm management practices, the lack of optimal donors, and recipient selection. In this study, the underlying factors of successful and unsuccessful FMT treatment cases are elucidated, and the potential markers for predicting successful FMT are identified using fecal metagenomics via 16S rRNA gene sequencing, fecal metabolomics via capillary electrophoresis time-of-flight mass spectrometry, and machine learning approaches. </sec><sec> <title>Results</title> Specifically, 20 FMT treatment cases, in which feces from healthy donors were intrarectally transferred into recipient diarrheal calves, were conducted with a success rate of 70%. <italic>Selenomonas</italic> was identified as a microorganism genus that showed significant donor–recipient compatibility in successful FMT treatments. A strong positive correlation between the microbiome and metabolome data, which is a prerequisite factor for FMT success, was confirmed by Procrustes analysis in successful FMT (<italic>r</italic> = 0.7439, <italic>P</italic> = 0.0001). Additionally, weighted gene correlation network analysis confirmed the positively or negatively correlated pairs of bacterial taxa (family <italic>Veillonellaceae</italic>) and metabolomic features (i.e., amino acids and short-chain fatty acids) responsible for FMT success. Further analysis aimed at establishing criteria for donor selection identified the genus <italic>Sporobacter</italic> as a potential biomarker in successful donor selection. Low levels of metabolites, such as glycerol 3-phosphate, dihydroxyacetone phosphate, and isoamylamine, in the donor or recipients prior to FMT, are predicted to facilitate FMT. </sec><sec> <title>Conclusions</title> Overall, we provide the first substantial evidence of the factors related to FMT success or failure; these findings could improve the design of future microbial therapeutics for treating diarrhea in calves. </sec>

  9. Fermented rice bran supplementation attenuates chronic colitis-associated extraintestinal manifestations in female C57BL/6N mice

    Jahidul Islam, Afifah Zahra Agista, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso, Yusuke Ohsaki, Takuya Koseki, Michio Komai, Hitoshi Shirakawa

    The Journal of Nutritional Biochemistry　99　108855-108855　2021/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.jnutbio.2021.108855 　

    ISSN： 0955-2863

  10. The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk

    Katsuki Usami, Kanae Niimi, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Shintaro Sato, Kohtaro Fujihashi, Hiroshi Kiyono, Saeka Uchino, Mutsumi Furukawa, Jahidul Islam, Kaori Ito, Taiki Moriya, Yutaka Kusumoto, Michio Tomura, Russell C. Hovey, Junichi Sugawara, Hiroshi Yoneyama, Haruki Kitazawa, Kouichi Watanabe, Hisashi Aso, Tomonori Nochi

    Cell Reports　36　(10)　109655-109655　2021/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.celrep.2021.109655 　

    ISSN： 2211-1247

  11. Fermented rice bran supplementation prevents the development of intestinal fibrosis due to dss-induced inflammation in mice

    Afifah Zahra Agista, Tubagus Bahtiar Rusbana, Jahidul Islam, Yusuke Ohsaki, Halima Sultana, Ryouta Hirakawa, Kouichi Watanabe, Tomonori Nochi, Ardiansyah, Slamet Budijanto, Suh Ching Yang, Takuya Koseki, Hisashi Aso, Michio Komai, Hitoshi Shirakawa

    Nutrients　13　(6)　2021/06

    DOI： 10.3390/nu13061869 　

    eISSN： 2072-6643

  12. Early life exposure to acephate exerts the neurobehavior and gut microbiota in adult mice

    SASAKI Takahiro, HASEGAWA Ayano, SAKAI Kazuya, HIRADATE Yuuki, HARA Kenshiro, ISLAM Jahidul, NOCHI Tomonori, TANEMURA Kentaro

    Annual Meeting of the Japanese Society of Toxicology　48　P-107S　2021

    Publisher: The Japanese Society of Toxicology

    DOI： 10.14869/toxpt.48.1.0_P-107S 　

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    <p>Acephate (Ace), an organophosphate insecticide, is also toxic to mammals. In this study, we examined the effects of chronic Ace exposure in early life on the brain functions and gut microbiota in adult male and female mice, including acceptable daily intake (ADI) level concentrations. These results suggested that chronic exposure to Ace during the early developmental stages, even at ADI level concentrations, leads to neurobehavioral diseases and disruption of the gut microbiota. The correlation between Ace-induced behavioral effects and an altered microbiome will be further investigated.</p>

  13. 発酵米糠によるデキストラン硫酸ナトリウム誘導性腸炎の改善

    Agista Afifah Zahra, Islam Jahidul, 大崎 雄介, 駒井 三千夫, 白川 仁

    無菌生物　50　(2)　97-99　2020/12

    Publisher: 日本無菌生物ノートバイオロジー学会

    ISSN： 0910-0903

  14. 発酵米糠によるデキストラン硫酸ナトリウム誘導大腸炎の改善

    Zahra Agista Afifah, Jahidul Islam, 大崎 雄介, 小関 卓也, 駒井 三千夫, 白川 仁

    日本栄養・食糧学会大会講演要旨集　74回　204-204　2020/04

    Publisher: (公社)日本栄養・食糧学会

  15. Emerging roles of nutraceuticals from selected fermented foods in lifestyle-related disease prevention

    Jahidul Islam, Hitoshi Shirakawa, Yearul Kabir

    Herbal Medicine in India: Indigenous Knowledge, Practice, Innovation and its Value　479-488　2019/01/01

    Publisher: Springer Singapore

    DOI： 10.1007/978-981-13-7248-3_29 　

  16. Development of rice bran functional food and evaluation of its healthful properties International-coauthorship Peer-reviewed

    Md Alauddin, Sadia Rahman, Jahidul Islam, Hitoshi Shirakawa, Michio Komai, Md Zakir Hossen Howlader

    Rice Bran and Rice Bran Oil: Chemistry, Processing and Utilization　183-206　2019/01/01

    DOI： 10.1016/B978-0-12-812828-2.00008-1 　

  17. Dietary Supplementation of Fermented Rice Bran Effectively Alleviates Dextran Sodium Sulfate-Induced Colitis in Mice Peer-reviewed

    Jahidul Islam, Takuya Koseki, Kouichi Watanabe, Ardiansyah, Slamet Budijanto, Akira Oikawa, Md Alauddin, Tomoko Goto, Hisahi Aso, Michio Komai, Hitoshi Shirakawa

    NUTRIENTS　9　(7)　747　2017/07

    DOI： 10.3390/nu9070747 　

    ISSN： 2072-6643

  18. Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice. International-journal Peer-reviewed

    Jahidul Islam, Shoko Sato, Kouichi Watanabe, Takaya Watanabe, Ardiansyah, Keisuke Hirahara, Yukihide Aoyama, Shuhei Tomita, Hisashi Aso, Michio Komai, Hitoshi Shirakawa

    The Journal of nutritional biochemistry　42　43-50　2017/04

    DOI： 10.1016/j.jnutbio.2016.12.019 　

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    Ulcerative colitis is the typical progression of chronic inflammatory bowel disease. Amino acids, particularly tryptophan, have been reported to exert a protective effect against colitis induced by dextran sodium sulfate (DSS), but the precise underlying mechanisms remain incompletely clarified. Tryptophan metabolites are recognized to function as endogenous ligands for aryl hydrocarbon receptor (Ahr), which is a critical regulator of inflammation and immunity. Thus, we conducted this study to investigate whether dietary tryptophan supplementation protects against DSS-induced colitis by acting through Ahr. Female wild-type (WT) and Ahr-deficient (knockout; KO) mice (10-12 weeks old) were divided into four groups and fed either a control or 0.5% tryptophan diet. The tryptophan diet ameliorated DSS-induced colitis symptoms and severity in WT mice but not in KO mice, and the diet reduced the mRNA expression of Il-6, Tnfα, Il-1β and the chemokines Ccl2, Cxcl1 and Cxcl2 in the WT groups. Furthermore, Il-22 and Stat3 mRNA expression in the colon was elevated in WT mice fed with the tryptophan diet, which mainly protected epithelial layer integrity, and Ahr also modulated immune homeostasis by regulating Foxp3 and Il-17 mRNA expression. These data suggest that tryptophan-containing diet might ameliorate DSS-induced acute colitis and regulate epithelial homeostasis through Ahr. Thus, tryptophan could serve as a promising preventive agent in the treatment of ulcerative colitis.

  19. Measurement of Serotonin Distribution and 5-Hydroxyindoleacetic Acid Excretion after Oral Administration of Serotonin using HPLC Fluorescence Detection. Peer-reviewed

    Islam J, Shirakawa H, Aso H, Komai M

    Food Science Nutrition and Technology　1　(1)　1-7　2017/01

  20. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats Peer-reviewed

    Md Alauddin, Hitoshi Shirakawa, Takuya Koseki, Naoko Kijima, Ardiansyah, Slamet Budijanto, Jahidul Islam, Tomoko Goto, Michio Komai

    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE　16　442　2016/11

    DOI： 10.1186/s12906-016-1427-z 　

    ISSN： 1472-6882

  21. Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC Peer-reviewed

    Jahidul Islam, Hitoshi Shirakawa, Thomas Kim Nguyen, Hisashi Aso, Michio Komai

    FOOD BIOSCIENCE　13　56-59　2016/03

    DOI： 10.1016/j.fbio.2015.12.006 　

    ISSN： 2212-4292

    eISSN： 2212-4306

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Misc. 3

  1. 食餌性トリプトファンが消化管におけるIgA産生に及ぼす影響

    Islam Jahidul, 白川 仁, 駒井 三千夫, 宇佐美 克紀, 野地 智法, 麻生 久

    無菌生物　48　(2)　84-85　2018/12

    Publisher: 日本無菌生物ノートバイオロジー学会

    ISSN： 0910-0903

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    査読あり

  2. Anti-inflammatory effect of metabolites of dietary tryptophan via aryl hydrocarbon receptor

    Islam Jahidul, 白川 仁, 駒井 三千夫

    無菌生物　48　(2)　51-55　2018/12

    Publisher: 日本無菌生物ノートバイオロジー学会

    ISSN： 0910-0903

  3. Rice bran as a functional food: An overview of the conversion of rice bran into a superfood / functional food.

    Alauddin M, Islam J, Shirakawa H, Koseki T, Ardiansyah, Komai M

    Superfood and Functional Food - An Overview of Their Processing and Utilization　2017/03

    Publisher: InTech, Rijeka, Croatia

    DOI： 10.5772/66298 　

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    責任著者

Presentations 5

  1. Establishing cross-farm fecal microbiota transplantation for the treatment of diarrhea in pre-weaned calves

    JAHIDUL ISLAM, Natsuki Ohtani, Yu Shimizu, Junya Yamazaki, Zen Nakamura, Hidekazu Tanaka, Tomonori Nochi

    The 133rd Annual Meeting of Japanese Society of Animal Science　2025/09/13

  2. Microbial Communities from Regionally Distinct Donors Exhibit Functional Redundancy in Fecal Microbiota Transplantation for Calf Diarrhea Treatment Invited

    Jahidul Islam

    2nd Joint Meeting of the Innovative Food Science Center　2025/09/09

  3. Introducing Fecal Microbiota Transplantation (FMT) for Calf Diarrhea Treatment Invited

    International Symposium on Designing Foods for the Future, Tohoku University, Japan　2024/09/20

  4. Establishing cross-FMT intervention for calf diarrhea treatment in pre-weaned calves Invited

    Jahidul Islam, Natsuki Ohtani, Junya Yamazaki, Zen Nakamura, Hidekazu Tanaka, Tomonori Nochi

    World Association For Buiatrics, Cancun, Mexico　2024/05/22

  5. Elucidation of the efficacy of fecal microbiota transplantation (FMT) in healing calves with intractable diarrhea

    Jahidul Islam, Masae Tanimizu, Yu Shimizu, Yoshiaki Goto, Natsuki Ohtani, Hidekazu Tanaka, Tomonori Nochi

    World Association For Buiatrics, Madrid, Spain　2022/09/06

Research Projects 4

  1. 乳汁抗体が有する“有用”微生物に対する特異的な作用機序

    野地智法, 濵口祐, 北澤春樹, Jahidul Islam, 西山啓太, 古川睦実, 平川良太

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2025/06 - 2027/03

  2. A Single-Cell-RNA Sequencing Based Strategy to Identify Host Cell Types and Cell Targets for Host-Microbiota Interaction in Calf Diarrhea

    Offer Organization: JSPS KAKENHI

    Institution: Graduate School of Agricultural Science, Tohoku University

    2025 - 2027

  3. Elucidating heterogeneity of IgA plasma cells between the small intestine and mammary glands during lactation by Single-Cell RNA-Seq

    Offer Organization: KAKENHI

    Institution: Graduate School of Agricultural Science, Tohoku University

    2023 - 2025

  4. An approach to increase the gut-derived maternal immunoglobulin A (IgA) production using dietary tryptophan via aryl hydrocarbon receptor

    Jahidul Islam

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04 - 2022/03

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    Feces of mice fed with 0.5% Trp-added basal feed or basal feed over time were collected and the IgA concentration in the feces was measured. Six weeks after the start of feeding, the large intestine was collected to address the number of plasma cells. In addition, using mice born 6 to 8 weeks after the start of feeding, feces and milk were collected to measure IgA concentration. The large intestine and mammary gland were collected in the second week of breastfeeding, to investigate the number of plasma cells. Fecal IgA levels increased significantly in the Trp group after 4 weeks of feeding bottom. However, there was no significant difference in the number of plasma cells in the large intestine 6 weeks after the start of feeding. Fecal IgA levels also increased significantly in the Trp group during early and late pregnancy. Trp is highly demanding, suggesting that Trp can enhance immunity in the intestinal tract.

Teaching Experience 1

  1. Fecal Microbiota Transplantation for Livestock Animals Wellbeing　5th Summer Course: Innovative Technology for Agroindustrial Sector in Society 5.0, organized By Faculty Of Agricultural Technology, Universitas Gadjah Mada, Indonesia