Details of the Researcher

PHOTO

Hitoshi Kasai
Section
Institute of Multidisciplinary Research for Advanced Materials
Job title
Professor
Degree

  • 博士（理学）（東北大学）

  • 修士（理学）（東北大学）

e-Rad No.
30312680

Professional Memberships 4

  • 繊維学会

  • 応用物理学会

  • 日本化学会

  • 高分子学会

Research Areas 4

  • Nanotechnology/Materials / Crystal engineering / Optical Materials

  • Nanotechnology/Materials / Applied materials / Optical Materials

  • Nanotechnology/Materials / Structural and functional materials / Structure and Fuctional Materials

  • Nanotechnology/Materials / Functional solid-state chemistry / Functional Materials and High Performance Materials

Papers 262

  1. Newly acylated SN-38 homodimers: carrier-free nano-prodrugs for chemotherapy

    Sanjay Kumar, Yoshitaka Koseki, Keita Tanita, Hitoshi Kasai

    Mendeleev Communications　35　(3)　278-281　2025/03/31

    Publisher: OOO Zhurnal "Mendeleevskie Soobshcheniya"

    DOI： 10.71267/mencom.7664 　

    ISSN： 0959-9436

    eISSN： 1364-551X

    More details Close

    Homodimers based on 7-ethyl-10-hydroxycamptothecin (SN-38) containing S<sub>2</sub>[(CH<sub>2</sub>)<sub>2</sub>OC(O)]<sub>2</sub> bridge and acyl substituents were synthesized and used for fabrication of nano-prodrugs. The latter demonstrated remarkable dispersion and stability over one month when stored at a temperature of 4 °C, with an ideal size of nanoparticles in the range of 80-130 nm that is required for EPR effect. The homodimer containing cyclopropylacetyl substituent chain exhibited significant anticancer efficacy against the HCT-116 and A-549 cell lines, with IC50 values having been 0.07 ± 0.01 and 0.29 ± 0.02 μm, respectively.

  2. Fluorinated Metal–Organic Frameworks: Hydrophobic Nanospaces with High Fluorine Density and Proton Conductivity Peer-reviewed

    Ryota Akai, Hitoshi Kasai, Kouki Oka

    Nanoscale　10.1039/d5nr00342c　2025/03/14

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d5nr00342c 　

    ISSN： 2040-3364

    eISSN： 2040-3372

    More details Close

    The current work revealed the relationship between the fluorine density of organic-based porous materials and water dynamics (proton conduction) in the hydrophobic nanospace. In detail, focusing on UiO-66 with structural...

  3. Iodine-Based Chemical Polymerization Enables the Development of Neat Amorphous Porous Organic Polymers Peer-reviewed

    Kohei Okubo, Haruka Yoshino, Hitoshi Miyasaka, Hitoshi Kasai, Kouki Oka

    ACS Applied Materials & Interfaces　17　(9)　14561-14568　2025/02/21

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsami.4c22197 　

    ISSN： 1944-8244

    eISSN： 1944-8252

  4. Triphenylamine‐Based Porous Organic Polymers with High Porosity: their High Carbon‐Dioxide Adsorption and Proton‐Conductivity Emergence Peer-reviewed

    Kohei Okubo, Showa Kitajima, Hitoshi Kasai, Kouki Oka

    Small　2410794　2025/02/17

    Publisher: Wiley

    DOI： 10.1002/smll.202410794 　

    ISSN： 1613-6810

    eISSN： 1613-6829

    More details Close

    Abstract Amorphous porous organic polymers (POPs) feature high specific surface area and chemical and thermal stability; therefore, they are applied in various fields. It is previously reported that chemical polymerization using iodine as an oxidant enables the synthesis of amorphous POPs without impurities. In this study, an iodine‐based chemical polymerization method is employed to maximize the specific surface area of polytriphenylamine, a typical amorphous POP. Furthermore, 1,3,5‐tris[4‐(diphenylamino)phenyl]benzene, a monomer with three triphenylamine moieties connected by a benzene core, is used to increase the number of reaction points and construct a rigid structure. The resulting poly[1,3,5‐tris[4‐(diphenylamino)phenyl]benzene] (pTTPA) exhibited a high specific surface area. Using 200 equivalents of iodine resulted in a pTTPA with the largest Brunauer–Emmett–Teller (BET) specific surface area (2134.6 m2 g−1) among previously reported triphenylamine‐based amorphous POPs, and demonstrated a high CO2 adsorption capacity (3.31 mmol g−1 at 25 °C). Furthermore, pTTPA exhibited significant water–vapor adsorption when the BET specific surface area reached 1500 m2 g−1, leading to the emergence of proton conductivity (e.g., 4.33 × 10−6 S cm−1 at 95% RH and 90 °C). The findings demonstrate that iodine‐based chemical polymerization enables the maximization of the porosity of amorphous POPs and the development of proton conductivity within them.

  5. SN-38-indoximod conjugate: carrier free nano-prodrug for cancer therapy Peer-reviewed

    Sanjay Kumar, Yoshitaka Koseki, Keita Tanita, Aki Shibata, Asuka Mizutani, Hitoshi Kasai

    Therapeutic Delivery　16　(3)　217-226　2025/01/31

    Publisher: Informa UK Limited

    DOI： 10.1080/20415990.2025.2458449 　

    ISSN： 2041-5990

    eISSN： 2041-6008

  6. Hydrophilization of hydrophobic azulene derivative by substitution with polyallylamine without drastically changing its optical properties Peer-reviewed

    Yo Kinoshita, Kiyotaka Maruoka, Yuta Takahashi, Yoko Teruuchi, Minoru Takeuchi, Kazuhiko Igarashi, Hitoshi Kasai, Kouki Oka

    MRS Communications　15　127-131　2024/11/25

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1557/s43579-024-00680-y 　

    eISSN： 2159-6867

  7. Sustained Drug Release from Dual‐Responsive Hydrogels for Local Cancer Chemo–Photothermal Therapy Peer-reviewed

    Zhixiang Liu, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    Macromolecular Bioscience　25　(3)　202400413　2024/11/20

    Publisher: Wiley

    DOI： 10.1002/mabi.202400413 　

    ISSN： 1616-5187

    eISSN： 1616-5195

    More details Close

    Abstract As an exceptional carrier for localized drug delivery to tumors, hydrogels can achieve prolonged drug release through careful design and adjustments, effectively targeting cancer cells and minimizing side effects. This study investigates a novel dual‐responsive hydrogel system designed for the delivery of nanomedicines, focusing on drug release and the local antitumor efficacy of SN‐38‐cholesterol nanoparticles (SN‐38‐chol NPs) and polydopamine NPs (PDA NPs)/poly(n‐isopropylacrylamide) (pNIPAM) hydrogels. By combining the thermosensitive properties of pNIPAM with the near‐infrared (NIR) responsiveness of PDA NPs, the hydrogel aims to enhance on‐demand drug release. SN‐38‐chol NPs, known for their stability and small size, are incorporated into the hydrogel to improve drug release dynamics. The investigation reveals a drug release cycle of over three weeks, maintaining sensitivity to both temperature and NIR light for controlled drug release. In vivo studies demonstrate the high tumor growth inhibition performance of the system after photothermal treatment induced by 808 nm NIR light. These results suggest that the drug‐carrying hydrogel system holds promise for diverse applications in chemical and physical therapies, including the treatment of malignant wounds, post‐surgery wound healing, and direct tumor treatment. This study establishes the potential of SN‐38‐chol NPs and PDA NPs/pNIPAM hydrogels as effective platforms for chemo‐phototherapy.

  8. Alkyl-Ether Group-Modified Anthraquinone-Based Negative Electrode for Enhanced Electrochemical Performance of All Solid-State Rechargeable Air Batteries Peer-reviewed

    Lin Guo, Kenji Miyatake, Suguru Wada, Kouki Oka, Showa Kitajima, Hitoshi Kasai, Ryota Tanaka, Hiroaki Imoto, Kensuke Naka, Fang Xian, Fanghua Liu, Ahmed Mohamed Ahmed Mahmoud, Vikrant Yadav, Chun Yik Wong

    ACS Sustainable Chemistry & Engineering　12　(45)　16518-16523　2024/11/01

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acssuschemeng.4c05143 　

    ISSN： 2168-0485

    eISSN： 2168-0485

  9. An ionic liquid containing arsonium cation Peer-reviewed

    Ryoto Inaba, Tomohiro Imai, Showa Kitajima, Hitoshi Kasai, Kouki Oka, Ryoyu Hifumi, Ikuyoshi Tomita, Masahiro Yoshizawa-Fujita, Kensuke Naka, Hiroaki Imoto

    Chemical Communications　60　(95)　14022-14025　2024/10/22

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4cc05072j 　

    ISSN： 1359-7345

    eISSN： 1364-548X

    More details Close

    We report the first arsonium-based ionic liquid, which shows lower viscosity, higher ionic conductivity, and comparable stability to phosphonium-based ones, expanding the range of ionic liquids beyond traditional ammonium and phosphonium cations.

  10. Unlocking the Charge‐Storage Potential of a Phenanthraquinone‐based Two‐Dimensional Covalent Organic Framework (2D COF) Peer-reviewed

    Tyran Günther, Daniel Hedbom, Michelle Åhlén, Haruka Yoshino, Hitoshi Miyasaka, Hitoshi Kasai, Kouki Oka, Rikard Emanuelsson

    ChemPlusChem　89　e202400184　2024/08/08

    Publisher: Wiley

    DOI： 10.1002/cplu.202400184 　

    ISSN： 2192-6506

    eISSN： 2192-6506

    More details Close

    Abstract The high surface area, open pore‐structure and atomic‐level organization inherent in many covalent organic frameworks (COFs) make them an attractive polymer platform for developing functional materials. Herein, a chemically robust 2D COF (TpOMe‐DAPQ COF) containing phenanthraquinone moieties was prepared by condensing 2,4,6‐trimethoxy‐1,3,5‐benzenetricarbaldehyde (TpOMe) and 2,7‐diamino‐9,10‐phenanthraquinone (DAPQ) using the convenient mechanochemical method. The poor charge‐storage capacity of the pristine TpOMe‐DAPQ COF was substantially improved by first investigating its redox‐site accessibility (RSA) using different conductivity‐enhancement methods, and then optimizing the amount of EDOT needed to perform an in‐situ polymerization. The resulting composite (0.4EDOT@TpOMe‐DAPQ) was characterized and its enhanced charge‐storage capabilities enabled it to be used as an anode material in an aqueous Mn beaker‐cell battery capable of delivering 0.76 V. This work outlines the rational design approach used to develop a functional charge‐storage material utilizing a COF‐based polymerization platform.

  11. Photodynamic antimicrobial activity of polydiacetylene crystal nanostructure against E. coli Peer-reviewed

    Mohammad Oves, Ryuju Suzuki, Hirotaka Nakatsuji, Yoshitaka Koseki, Sanjay Kumar, Kouki Oka, Hitoshi Kasai

    MRS Communications　14　1307-1312　2024/08/08

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1557/s43579-024-00622-8 　

    eISSN： 2159-6867

  12. Carrier-free nano-prodrugs for minimally invasive cancer therapy Peer-reviewed

    Keita Tanita, Yoshitaka Koseki, Sanjay Kumar, Farsai Taemaitree, Asuka Mizutani, Hirotaka Nakatsuji, Ryuju Suzuki, Anh Thi Ngoc Dao, Fumiyoshi Fujishima, Hiroshi Tada, Takanori Ishida, Ken Saijo, Chikashi Ishioka, Hitoshi Kasai

    Nanoscale　16　(32)　15256-15264　2024/07/26

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4nr01763c 　

    ISSN： 2040-3364

    eISSN： 2040-3372

    More details Close

    SNC4DC, a dimer of SN-38 derivatives, has been synthesized. SNC4DC nanoparticles called nano-prodrugs are internalized into the cell and dissociate, and the active SN-38 is released after reduction of the S–S bond in the presence of GSH occurs.

  13. A concise synthesis of methyl dihydrojasmonate and methyl (5-methylidene-4-oxocyclopent-2-en-1-yl)acetate from D-glucose Peer-reviewed

    Sanjay Kumar, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

    Mendeleev Communications　34　(4)　528-530　2024/07

    Publisher: OOO Zhurnal "Mendeleevskie Soobshcheniya"

    DOI： 10.1016/j.mencom.2024.06.019 　

    ISSN： 0959-9436

  14. Controlling the composition and nanostructure of Au@Ag–Pt core@multi-shell nanoparticles prepared by co-reduction method Peer-reviewed

    Hu-Jun Lee, Daisuke Hanyu, Anh Thi Ngoc Dao, Hitoshi Kasai, Minori Suzuki, Hiroshi Yabu, Hisayuki Nakatani, Kenji Kaneko

    Materials Today Chemistry　38　102132　2024/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.mtchem.2024.102132 　

    ISSN： 2468-5194

  15. Fabrication of carrier-free heterodimeric nano-prodrugs with podophyllotoxin and SN-38 for a co-delivery system Peer-reviewed

    Yoshitaka Koseki, Keita Tanita, Motofumi Nakamura, Aki Shibata, Kiyotaka Maruoka, Takaaki Kamishima, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　768　(12)　481-487　2024/05/28

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2024.2353966 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  16. Anticancer Nano-prodrugs with Drug Release triggered by Intracellular Dissolution and Hydrogen Peroxide Response Peer-reviewed

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Showa Kitajima, Kouki Oka, Kiyotaka Maruoka, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    Chemical Communications　60　6427-6430　2024/03/31

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4cc02252a 　

    ISSN： 1359-7345

    eISSN： 1364-548X

    More details Close

    We developed the prodrug nanoparticles that release drugs through intracellular dissolution and cancer-specific hydrogen peroxide response. To reveal the unclear mechanism regarding drug release from nanoparticles by reacting with hydrogen...

  17. Combined substituent number utilized machine learning for the development of antimicrobial agent Peer-reviewed

    Keitaro Yamauchi, Hirotaka Nakatsuji, Takaaki Kamishima, Yoshitaka Koseki, Masaki Kubo, Hitoshi Kasai

    Scientific Reports　14　4106　2024/02/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-53888-2 　

    eISSN： 2045-2322

    More details Close

    Abstract The utilization of machine learning has a potential to improve the environment of the development of antimicrobial agents. For practical use of machine learning, it is important that the conversion of molecules information to an appropriate descriptor because too informative descriptor requires enormous computation time and experiments for gathering data, whereas a less informative descriptor has problems in validity. In this study, we utilized a descriptor only focused on substituent. The type and the position of substituents on the molecules that have a 4-quinolone structure (11,879 compounds) were converted to the combined substituent number (CSN). While the CSN does not include information on the detailed structure, physical properties, and quantum chemistry of molecules, the prediction model constructed by machine learning of CSN indicated a sufficient coefficient of determination (0.719 for the training dataset and 0.519 for the validation dataset). In addition, this CSN can easily construct the unknown molecules library which has a relatively consistent structure by recombination of substituents (32,079,318 compounds) and screening of them. The validity of the prediction model was also confirmed by growth inhibition experiments for E. coli using the model-suggested molecules and commercially available antimicrobial agents.

  18. Developing porous electrocatalysts to minimize overpotential for the oxygen evolution reaction Peer-reviewed

    Takahiro Ami, Kouki Oka, Hitoshi Kasai, Tatsuo Kimura

    Chemical Communications　61　(8)　1533-1558　2024/01/21

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4cc05348f 　

    ISSN： 1359-7345

    eISSN： 1364-548X

    More details Close

    This feature article mainly outlines the advances in the precise design of inorganic- and organic-based porous electrocatalysts towards the enhancement of oxygen evolution reaction (OER) properties to achieve efficient water-splitting reaction.

  19. Selective emergence of photoluminescence at telecommunication wavelengths from cyclic perfluoroalkylated carbon nanotubes Peer-reviewed

    Yutaka Maeda, Yasuhiro Suzuki, Yui Konno, Pei Zhao, Nobuhiro Kikuchi, Michio Yamada, Masaya Mitsuishi, Anh T. N. Dao, Hitoshi Kasai, Masahiro Ehara

    Communications Chemistry　6　159　2023/07/31

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42004-023-00950-1 　

    eISSN： 2399-3669

  20. Total Synthesis of Azulene Derivative, a Blue Pigment Isolated from Lactarius indigo, and Colorant Application of Its Aqueous Dispersion Peer-reviewed

    Kiyotaka Maruoka, Ryuju Suzuki, Takaaki Kamishima, Yoshitaka Koseki, Anh Thi Ngoc Dao, Toshihiro Murafuji, Hitoshi Kasai

    Journal of Agricultural and Food Chemistry　71　(30)　11607-11614　2023/07/12

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.jafc.3c02387 　

    ISSN： 0021-8561

    eISSN： 1520-5118

  21. Sensitive and simple multi-ion detection using organic nanocrystal enrichment in paper analytical devices Peer-reviewed

    Grasianto, Mao Fukuyama, Motohiro Kasuya, Derrick M. Mott, Yoshitaka Koseki, Hitoshi Kasai, Akihide Hibara

    Analytica Chimica Acta　1273　341451　2023/06/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.aca.2023.341451 　

    ISSN： 0003-2670

  22. Selective Detection of Intracellular Drug Metabolism by Metal‐Organic Framework‐Coated Plasmonic Nanowire Peer-reviewed

    Qiang Zhang, Taku Murasugi, Kotomi Watanabe, Han Wen, Ya Tian, Monica Ricci, Susana Rocha, Tomoko Inose, Hitoshi Kasai, Farsai Taemaitree, Hiroshi Uji‐i, Kenji Hirai, Beatrice Fortuni

    Advanced Optical Materials　11　(22)　202300856　2023/05/21

    Publisher: Wiley

    DOI： 10.1002/adom.202300856 　

    ISSN： 2195-1071

    eISSN： 2195-1071

  23. Label-Free Tracking of Nanoprodrug Cellular Uptake and Metabolism Using Raman and Autofluorescence Imaging Peer-reviewed

    Masato Machida, Toshiki Sugimura, Shinji Kajimoto, Farsai Taemaitree, Yoshitaka Koseki, Hitoshi Kasai, Takakazu Nakabayashi

    The Journal of Physical Chemistry B　127　(17)　3851-3860　2023/04/24

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.jpcb.3c01133 　

    ISSN： 1520-6106

    eISSN： 1520-5207

  24. Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy Peer-reviewed

    Senthilkumar Thirumurugan, Kayalvizhi Samuvel Muthiah, Rajalakshmi Sakthivel, Mei-Yi Liao, Hitoshi Kasai, Ren-Jei Chung

    Pharmaceutics　15　(3)　822-822　2023/03/02

    Publisher: MDPI AG

    DOI： 10.3390/pharmaceutics15030822 　

    eISSN： 1999-4923

    More details Close

    Herein, we present a one-pot hydrothermal approach for synthesizing metal–organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.32% after PDA coating and exhibited good photothermal stability. Moreover, NWs with a suitable T1 relaxivity coefficient (r1 = 3.01 mg−1 s−1) can be effectively used as magnetic resonance imaging (MRI) contrast agents. By increasing concentrations, cellular uptake studies showed a greater uptake of Cu-BTC@PDA NWs into cancer cells. Further, in vitro studies showed PDA-coated Cu-BTC NWs possess exceptional therapeutic performance by 808 nm laser irradiation, destroying 58% of cancer cells compared with the absence of laser irradiation. This promising performance is anticipated to advance the research and implementation of copper-based NWs as theranostic agents for cancer treatment.

  25. Fabrication of anti-inflammatory nano eye-drops composed of dexamethasone prodrugs Peer-reviewed

    Keita Tanita, Mai Iijima, Yoshitaka Koseki, Kota Sato, Toru Nakazawa, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　762　(1)　81-87　2023/02/23

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2023.2180212 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  26. Ir‐Catalysed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis‐allyl Alcohols Peer-reviewed

    Takaaki Kamishima, Yoshitaka Koseki, Hirotaka Nakatsuji, Sanjay Kumar, Keita Tanita, Hitoshi Kasai

    European Journal of Organic Chemistry　2022　(43)　e202201002　2022/10/11

    Publisher: Wiley

    DOI： 10.1002/ejoc.202201002 　

    ISSN： 1434-193X

    eISSN： 1099-0690

  27. Development of Camptothecin Nano-Prodrugs based on Trimethyl Lock Groups toward Selective Drug Release in Cancer Cells Peer-reviewed

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    Tetrahedron Letters　103　153989　2022/07/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.tetlet.2022.153989 　

    ISSN： 0040-4039

  28. Versatile Conversions of Substituents in Guaiazulene: Synthesis of Carboxylic Acid Derivatives with Controlled Regiospecific Reactivities Peer-reviewed

    Kiyotaka Maruoka, Takaaki Kamishima, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Toshihiro Murafuji, Hitoshi Kasai

    Bulletin of the Chemical Society of Japan　95　(8)　1169-1177　2022/06/15

    Publisher: Oxford University Press (OUP)

    DOI： 10.1246/bcsj.20220122 　

    ISSN： 0009-2673

    eISSN： 1348-0634

    More details Close

    Abstract Azulene derivatives such as guaiazulene have unique properties and thus play important roles in electronic materials. However, the application of these materials is limited by the lack of functionalization approaches for guaiazulene extracted from natural products. Herein, we report a method for the synthesis of three guaiazulene carboxylic acid derivatives in four to five steps by controlling the reactivity of guaiazulene. 7-Isopropyl-4-methylazulene-1-carboxylic acid was prepared by protecting the C-3 position of guaiazulene with an ester group to inhibit unexpected reactions. We also introduced a carboxyl group at the inactive C-2 position of guaiazulene using a boryl group as a key intermediate. The C4-methyl group of guaiazulene was converted to a formyl group utilizing the acidity of the protons on the C4-methyl group. By protecting the C-3 position of guaiazulene with a tosyl group, 7-isopropyl-1-methylazulene-4-carboxylic acid was synthesized via Kraus-Pinnick oxidation. Ultraviolet/visible spectra of the synthesized guaiazulene carboxylic acids indicate that the longest wavelength at maximum absorption varied depending on the substitution position of the carboxyl group in guaiazulene. Guaiazulene carboxylic derivatives will serve as building blocks for the development of guaiazulene-based materials because the carboxyl group can be converted to various functional groups.

  29. Total synthesis and antimicrobial evaluation of (+)-hygrophorone B12 and its analogues International-journal Peer-reviewed

    Takaaki Kamishima, Masato Suzuki, Koichi Narita, Yoshitaka Koseki, Toshiyuki Nonaka, Hirotaka Nakatsuji, Hideo Hattori, Hitoshi Kasai

    Scientific Reports　12　(1)　7471-7471　2022/05/06

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-11608-8 　

    eISSN： 2045-2322

    More details Close

    This paper describes the synthesis and evaluation of lead compounds with a new chemical skeleton that is not found in conventional antimicrobial agents. The biologically attractive cyclopentenoid (+)-hygrophorone B12, isolated from the fruiting bodies of Hygrophorus abieticola, and its analogues were synthesized in a longer linear sequence of twelve steps, starting from a cyclopentenone derivative. This synthesis involved the following crucial steps: (i) oximation of a ketone to stabilize the requisite aldehyde to install a side chain and (ii) coupling of an aldehyde with a side chain to assemble the desired hygrophorone. Then, the antimicrobial activity of these hygrophorones towards clinically relevant bacterial pathogens was evaluated. The results showed that hygrophorone B12 and its analogues are especially effective in preventing the proliferation of gram-positive bacteria. In addition, it was found that some structural features such as the presence of the enone moiety as well as the carbon–carbon triple bond on the hydrocarbon chain were pivotal to increase the antimicrobial activity of hygrophorone B. This study is expected to support the development of novel antimicrobial agents by flexibly synthesizing hygrophorone B analogues with a carbon five-membered ring skeleton from the common intermediate.

  30. Design of guaiazulene derivatives-conjugated podophyllotoxin nano-prodrug toward anticancer drug delivery Peer-reviewed

    Kiyotaka Maruoka, Yoshitaka Koseki, Anh Thi Ngoc Dao, Ryuju Suzuki, Anudari Batbayar, Nagaki Sugeno, Hirohito Umezawa, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　744　(1)　1-9　2022/03/25

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2022.2056384 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  31. Polymeric functionalization of podophyllotoxin carrier-free drug nanoparticles for enhancing bioavailability and in vitro cellular imaging Peer-reviewed

    Farsai Taemaitree, Masamichi Tamada, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　743　(1)　89-95　2022/03/24

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2022.2052491 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  32. Conversion of 2,5-Bis(hydroxymethyl)furan to Highly Oxidized Cyclopentenones under Catalyst-Free Condition in Water Peer-reviewed

    Hirotaka Nakatsuji, Takaaki Kamishima, Toshiyuki Nonaka, Yoshitaka Koseki, Hitoshi Kasai

    Chemistry Letters　51　(5)　497-499　2022/03/01

    Publisher: The Chemical Society of Japan

    DOI： 10.1246/cl.220027 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  33. Structural Correlations of the Nonlinear Optical Response in Polydiacetylene Nanotubes Hybridized with Gold Nanoparticles Peer-reviewed

    Wakana Ito-Washiyama, Tsunenobu Onodera, Masaki Ageishi, Rodrigo Sato, Boyi Zhang, Satoshi Kato, Akito Masuhara, Hitoshi Kasai, Hiroaki Mamiya, Hiroshi Jinnai, Yoshihiko Takeda, Hidetoshi Oikawa

    The Journal of Physical Chemistry C　126　(5)　2763-2771　2022/01/27

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.jpcc.1c08884 　

    ISSN： 1932-7447

    eISSN： 1932-7455

  34. Gold-Photodeposited Silver Nanowire Endoscopy for Cytosolic and Nuclear pH Sensing Peer-reviewed

    Qiang Zhang, Tomoko Inose, Monica Ricci, Jiangtao Li, Ya Tian, Han Wen, Shuichi Toyouchi, Eduard Fron, Anh Thi Ngoc Dao, Hitoshi Kasai, Susana Rocha, Kenji Hirai, Beatrice Fortuni, Hiroshi Uji-i

    ACS Applied Nano Materials　4　(9)　9886-9894　2021/09/07

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsanm.1c02363 　

    ISSN： 2574-0970

    eISSN： 2574-0970

  35. Formation of multishell Au@Ag@Pt nanoparticles by coreduction method: a microscopic study Peer-reviewed

    Y. Takeuchi, H.-J. Lee, A.T.N. Dao, H. Kasai, R. Teranishi, K. Kaneko

    Materials Today Chemistry　21　100515-100515　2021/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.mtchem.2021.100515 　

    ISSN： 2468-5194

  36. Fabrication of Size-controlled SN-38 Pure Drug Nanocrystals Through an Ultrasound-Assisted Reprecipitation Method toward Efficient Drug Delivery for Cancer Treatment Peer-reviewed

    Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    Journal of Crystal Growth　572　126265　2021/07/24

    Publisher: Elsevier BV

    DOI： 10.1016/j.jcrysgro.2021.126265 　

    ISSN： 0022-0248

  37. Serum Albumin-Treated SN-38 Prodrug Nanoparticles toward Cancer Treatment Peer-reviewed

    Farsai Taemaitree, Yoshitaka Koseki, Anh Thi Ngoc Dao, Hitoshi Kasai

    Chemistry Letters　50　(8)　1555-1558　2021/06/09

    Publisher: The Chemical Society of Japan

    DOI： 10.1246/cl.210253 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  38. Organic nanocrystal enrichment in paper microfluidic analysis Peer-reviewed

    Grasianto, Mao Fukuyama, Derrick M. Mott, Yoshitaka Koseki, Hitoshi Kasai, Akihide Hibara

    Sensors and Actuators B: Chemical　333　129548-129548　2021/01/28

    DOI： 10.1016/j.snb.2021.129548 　

    ISSN： 0925-4005

    eISSN： 0925-4005

  39. Ultra-low dielectric properties of porous polyimide thin films fabricated by using the two kinds of templates with different particle sizes Peer-reviewed

    Yumi Kourakata, Tsunenobu Onodera, Hitoshi Kasai, Hiroshi Jinnai, Hidetoshi Oikawa

    Polymer　212　123115　2020/10/06

    Publisher: Elsevier BV

    DOI： 10.1016/j.polymer.2020.123115 　

    ISSN： 0032-3861

  40. Low-Cytotoxic Gold-Coated Silver Nanoflowers for Intracellular pH Sensing Peer-reviewed

    Qiang Zhang, Han Wen, Kiri Watanabe, Ibuki Kotani, Monica Ricci, Beatrice Fortuni, Anh Thi Ngoc Dao, Akito Masuhara, Kenji Hirai, Hitoshi Kasai, Tomoko Inose, Hiroshi Uji-i

    ACS Applied Nano Materials　3　(8)　7643-7650　2020/08/28

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsanm.0c01278 　

    ISSN： 2574-0970

    eISSN： 2574-0970

  41. Effect of the chemical structure on the drug release from brinzolamide based nano eye-drops Peer-reviewed

    Yoshitaka Koseki, Yoshikazu Ikuta, Kota Sato, Shigenobu Aoyagi, Satoshi Inada, Tsunenobu Onodera, Hidetoshi Oikawa, Koji M. Nishiguchi, Toru Nakazawa, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　706　(1)　122-128　2020/07/23

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2020.1743447 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  42. Self-assemble tannic acid and iron complexes on pure nanodrugs surface prevents aggregation and enhances anticancer drug delivery efficiency Peer-reviewed

    Farsai Taemaitree, Yoshitaka Koseki, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　706　(1)　116-121　2020/07/23

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2020.1743446 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  43. Fabrication of Hinokitiol-modified podophyllotoxin nano-prodrugs having a high drug loading capacity Peer-reviewed

    Keita Tanita, Yoshitaka Koseki, Kazue Shimizu, Hirohito Umezawa, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　706　(1)　79-85　2020/07/23

    Publisher: Informa UK Limited

    DOI： 10.1080/15421406.2020.1743441 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  44. Solid-State Polymerization Behaviors of Polydiacetylene Nanofibers Peer-reviewed

    Rie Chiba, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    Molecular Crystals and Liquid Crystals　DOI: 10.1080/15421406.2020.1741807　2020/03

  45. Chemical modification utilizing a terminal structure exposed on the specific surface of polymer-metal complex nanocrystals Peer-reviewed

    R. Suzuki, T. Onodera, H. Kasai, H. Oikawa

    RSC Adv.　11　6135-6138　2020/02

  46. Metal ion enrichment using organic nanocrystal coatedmicrofluidic paper analytical devices to achieve highly sensitive colorimetric detection Peer-reviewed

    Grasianto, Mao Fukuyama, Derrick Mott, Yoshitaka Koseki, Hitoshi Kasai, Akihide Hibara

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences　567-568　2020

    Publisher: Chemical and Biological Microsystems Society

  47. FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Eduard Fron, Susana Rocha, Johan Hofkens, Hiroshi Uji-i, Tomoko Inose, Hitoshi Kasai

    Nanoscale　12　(32)　16710-16715　2020

    DOI： 10.1039/d0nr04910g 　

    ISSN： 2040-3364

    eISSN： 2040-3372

  48. Tropone Skeleton Enhances the Dispersion Stability of Nano-prodrugs Peer-reviewed

    K. Tanita, Y. Koseki, T. Kamishima, H. Kasai

    Chem. Lett.,　43　222-224　2020/01

  49. Third-Order Nonlinear Optical Properties of Layered Type Hybridized Thin Films Consisted of Oriented Polydiacetylene Nanofibers and Silver Nanoparticles Peer-reviewed

    K.Wada, T.nodera, H.Kasai, R.Sato, Y.Takeda, H.Oikawa

    The Journal of Physical Chemistry　123　(42)　25781-25787　2019/10

    DOI： 10.1021/acs.jpcc.9b05665 　

  50. Morphological effects on the third-order nonlinear optical response of polydiacetylene nanofibers Peer-reviewed

    H.Maki, R.Chiba, T.Onodera, H.Kasai, R.Sato, Y.Takeda, H.Oikawa

    MRS Communications　9　(3)　1087-1092　2019/08

    DOI： 10.1557/mrc.2019.97 　

  51. Formation of Five-membered Carbocycles from D-Glucose: A Concise Synthesis of 4-Hydroxy-2-(hydroxymethyl)cyclopentenone Peer-reviewed

    Y. Koseki, T. Watanabe, T. Kamishima, E. Kwon, H. Kasai

    Bull. Chem. Soc. Jpn., In press　92　(8)　1324-1328　2019/06

    DOI： 10.1246/bcsj.20190063 　

  52. A facile synthesis of (+)/(−)-pentenomycin I and analogs, and their antimicrobial evaluation Peer-reviewed

    T. Kamishima, M. Suzuki, S. Aoyagi, T. Watanabe, Y. Koseki, H. Kasai

    Tetrahedron Lett　60　(20)　1375-1378　2019/04

    DOI： 10.1016/j.tetlet.2019.04.026 　

    ISSN： 0040-4039

  53. Influence of hydrolysis susceptibility and hydrophobicity of Sn-38 nano-prodrugs on their anticancer activity Peer-reviewed

    Yoshitaka Koseki, Yoshikazu Ikuta, Liman Cong, Mayumi Takano-Kasuya, Hiroshi Tada, Mika Watanabe, Kohsuke Gonda, Takanori Ishida, Noriaki Ohuchi, Keita Tanita, Farsai Taemaitree, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    Bulletin of the Chemical Society of Japan　92　(8)　1305-1313　2019

    DOI： 10.1246/bcsj.20190088 　

    ISSN： 0009-2673

    eISSN： 1348-0634

  54. Enhanced Fluorescence Emission and Magnetic Alignment Control of Biphasic Functionalized Composite Janus Particles Peer-reviewed

    Naonari Sakamoto, Yutaro Hirai, Tsunenobu Onodera, Takuma Dezawa, Yutaka Shibata, Hitoshi Kasai, Hidetoshi Oikawa, Hiroshi Yabu

    Particles and Particle Systems Characterization　1800311　(1)　1-8　2019/01

    DOI： 10.1002/ppsc.201800311 　

    ISSN： 0934-0866

    eISSN： 1521-4117

  55. Nanocrystallization effect on luminescence properties of polymer-metal complex with different kinds of ligands Peer-reviewed

    Ryuju Suzuki, Tsunenobu Onodera, Shigeru Deguchi, Hitoshi Kasai, Hidetoshi Oikawa

    Journal of the Taiwan Institute of Chemical Engineers　92　129-133　2018/11

    DOI： 10.1016/j.jtice.2018.02.022 　

    ISSN： 1876-1070

  56. One-Step Conversion to a Disubstituted Cyclopentenone from 2-Deoxy-D-Glucose and Application to Synthesis of Prostaglandin E1 Methyl Ester Peer-reviewed

    T. Kamishima, T. Nonaka, T. Watanabe, Y. Koseki, H. Kasai

    Bulletin of the Chemical Society of Japan　91　(12)　1691-1696　2018/10

    DOI： 10.1246/bcsj.20180241 　

    ISSN： 0009-2673

    eISSN： 1348-0634

  57. Fabrication Technique of Organic Nanocrystals and Their Optical Properties and Materialization

    Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Nanoparticle Technology Handbook　739-744　2018/05/11

    Publisher: Elsevier

    DOI： 10.1016/B978-0-444-64110-6.00070-6 　

  58. Attempt to visualize terminal structure on a specific facet in polymer-metal complex nanocrystals Peer-reviewed

    Ryuju Suzuki, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    RSC Advances　8　(30)　16406-16409　2018

    Publisher: Royal Society of Chemistry

    DOI： 10.1039/c8ra02165a 　

    ISSN： 2046-2069

  59. Synthesis of ordered carbonaceous frameworks from organic crystals Peer-reviewed

    Hirotomo Nishihara, Tetsuya Hirota, Kenta Matsuura, Mao Ohwada, Norihisa Hoshino, Tomoyuki Akutagawa, Takeshi Higuchi, Hiroshi Jinnai, Yoshitaka Koseki, Hitoshi Kasai, Yoshiaki Matsuo, Jun Maruyama, Yuichiro Hayasaka, Hisashi Konaka, Yasuhiro Yamada, Shingi Yamaguchi, Kazuhide Kamiya, Takuya Kamimura, Hirofumi Nobukuni, Fumito Tani

    NATURE COMMUNICATIONS　8　109-1-109-9　2017/07

    DOI： 10.1038/s41467-017-00152-z 　

    ISSN： 2041-1723

  60. Fabrication of gold clusters photoreduced in gold-dendrimer complex nanoparticles Peer-reviewed

    Akira Miura, Tsunenobu Onodera, Hitoshi Kasai, Takane Imaoka, Kimihisa Yamamoto, Hidetoshi Oikawa

    OPTICAL MATERIALS EXPRESS　7　(7)　2224-2229　2017/07

    DOI： 10.1364/OME.7.002224 　

    ISSN： 2159-3930

  61. Fabrication of pseudo single crystalline thin films composed of polydiacetylene nanofibers and their optical properties Peer-reviewed

    Yuki Iimori, Tsunenobu Onodera, Hitoshi Kasai, Masaya Mitsuishi, Tokuji Miyashita, Hidetoshi Oikawa

    OPTICAL MATERIALS EXPRESS　7　(7)　2218-2223　2017/07

    DOI： 10.1364/OME.7.002218 　

    ISSN： 2159-3930

  62. Creation of nano eye-drops and effective drug delivery to the interior of the eye Peer-reviewed

    Yoshikazu Ikuta, Shigenobu Aoyagi, Yuji Tanaka, Kota Sato, Satoshi Inada, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    SCIENTIFIC REPORTS　7　44229　2017/03

    DOI： 10.1038/srep44229 　

    ISSN： 2045-2322

  63. Photoresponse of azopyridine-modified polymer-metal complex nanocrystals Peer-reviewed

    Ryuju Suzuki, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　654　(1)　109-114　2017

    DOI： 10.1080/15421406.2017.1355712 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  64. Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug Peer-reviewed

    Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN　89　(5)　540-545　2016/05

    DOI： 10.1246/bcsj.20150405 　

    ISSN： 0009-2673

    eISSN： 1348-0634

  65. Fabrication and characterization of C60 fine crystals and their hybridization Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawac

    Fullerene Nanowhiskers　89-101　2016/04/19

    Publisher: Pan Stanford Publishing Pte. Ltd.

  66. Topical ocular dexamethasone decreases intraocular pressure and body weight in rats Peer-reviewed

    Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai, Toru Nakazawa

    Journal of Negative Results in BioMedicine　15　(1)　2016/03/12

    Publisher: BioMed Central Ltd.

    DOI： 10.1186/s12952-016-0048-x 　

    ISSN： 1477-5751

  67. Selective surface-modification in main-chain polymer-metal complex nanocrystals Peer-reviewed

    R. Suzuki, T. Onodera, H. Kasai, H. Oikawa

    22nd International Congress of Chemical and Process Engineering, CHISA 2016 and 19th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2016　1　564-565　2016

    Publisher: Czech Society of Chemical Engineering

  68. Dispersion control of perylene fluorophores in a polystyrene microsphere Peer-reviewed

    Koshiro Yoshioka, Tsunenobu Onodera, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　629　(1)　239-242　2016

    DOI： 10.1080/15421406.2015.1096445 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  69. Nanoscale deposition of metal-organic framework films on polymer nanosheets Peer-reviewed

    Hiroaki Ohara, Shunsuke Yamamoto, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa, Tokuji Miyashita, Masaya Mitsuishi

    RSC ADVANCES　6　(78)　74349-74353　2016

    DOI： 10.1039/c6ra17997e 　

    ISSN： 2046-2069

  70. Cytotoxicity of Pure Nanodrugs of SN-38 and Podophyllotoxin Dimers in Human Cancer HepG2, KPL-4, and MCF-7 Cells Peer-reviewed

    Yoshitaka Koseki, Yoshikazu Ikuta, Tatsuya Murakami, Tsunenobu Onodera, Hidetoshi Oikawa, Liman Cong, Hiroshi Tada, Kohsuke Gonda, Noriaki Ohuchi, Hitoshi Kasai

    Molecular Crystals and Liquid Crystals　622　(1)　1-5　2015/11/22

    DOI： 10.1080/15421406.2015.1096483 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  71. Nanocrystallization of Insoluble Copper(I) Complex and Formation Mechanism Peer-reviewed

    Ryuju Suzuki, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　621　(1)　150-155　2015/11

    DOI： 10.1080/15421406.2015.1096450 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  72. Novel Development for Fabrication of Size- and Morphology-controlled Titanylphthalocyanine Nanocrystals Peer-reviewed

    Takuya Kikuchi, Kaito Kogure, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    CHEMISTRY LETTERS　44　(9)　1232-1233　2015/09

    DOI： 10.1246/cl.150365 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  73. The effect of molecular structure on the anticancer drug release rate from prodrug nanoparticles Peer-reviewed

    Yoshikazu Ikuta, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    CHEMICAL COMMUNICATIONS　51　(64)　12835-12838　2015

    DOI： 10.1039/c5cc04164c 　

    ISSN： 1359-7345

    eISSN： 1364-548X

  74. Organic crystal-binding peptides: morphology control and one-pot formation of protein-displaying organic crystals Peer-reviewed

    Teppei Niide, Kyohei Ozawa, Hikaru Nakazawa, Daniel Oliveira, Hitoshi Kasai, Mari Onodera, Ryutaro Asano, Izumi Kumagai, Mitsuo Umetsu

    NANOSCALE　7　(47)　20155-20163　2015

    DOI： 10.1039/c5nr06471f 　

    ISSN： 2040-3364

    eISSN： 2040-3372

  75. Fabrication of fluorescent copper complex nanoparticles by the heterogeneous reaction process Peer-reviewed

    Ryuju Suzuki, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    JAPANESE JOURNAL OF APPLIED PHYSICS　53　(6)　1-4　2014/06

    DOI： 10.7567/JJAP.53.06JH03 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  76. Facile deposition of gold nanoparticles on C60 microcrystals with unique shapes Peer-reviewed

    Zhenquan Tan, Akito Masuhara, Satoshi Ohara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Journal of Nanoparticle Research　15　(11)　1-10　2013/11

    DOI： 10.1007/s11051-013-2029-z 　

    ISSN： 1388-0764 1572-896X

  77. Thermal-induced shape transformation of solvated C60 microcrystals Peer-reviewed

    Zhenquan Tan, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Carbon　64　370-376　2013/11

    DOI： 10.1016/j.carbon.2013.07.087 　

    ISSN： 0008-6223

  78. Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity Peer-reviewed

    Yoshikazu Ikuta, Yoshitaka Koseki, Tatsuya Murakami, Minoru Ueda, Hidetoshi Oikawa, Hitoshi Kasai

    CHEMISTRY LETTERS　42　(8)　900-901　2013/08

    DOI： 10.1246/cl.130224 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  79. Diarylethene Nanorods: Preparation, Crystal Structure, and Photochromic Properties Peer-reviewed

    Norio Tagawa, Akito Masuhara, Shuji Okada, Hiroshi Katagiri, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    CHEMISTRY LETTERS　42　(6)　636-637　2013/06

    DOI： 10.1246/cl.130023 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  80. Highly Controlled Plasmonic Emission Enhancement from Metal-Semiconductor Quantum Dot Complex Nanostructures Invited Peer-reviewed

    Hiroyuki Naiki, Akito Masuhara, Sadahiro Masuo, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    JOURNAL OF PHYSICAL CHEMISTRY C　117　(6)　2455-2459　2013/02

    DOI： 10.1021/jp305408p 　

    ISSN： 1932-7447

  81. Perylene and Perylene-Derivative Nano-Cocrystals: Preparation and Physicochemical Property Peer-reviewed

    Koichi Baba, Sayaka Konta, Daniel Oliveira, Kenji Sugai, Tsunenobu Onodera, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　51　(12)　125201-1-6　2012/12

    DOI： 10.1143/JJAP.51.125201 　

    ISSN： 0021-4922

  82. Preparation and Luminescence Properties of Organic Phosphorescent Nanoparticles Peer-reviewed

    Yousuke Miyashita, Shinichi Horino, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　51　(2)　025002-1-025002-5　2012/02

    DOI： 10.1143/JJAP.51.025002 　

    ISSN： 0021-4922

  83. Fabrication of Polyimide Porous Nanostructures for Low-k Materials

    Ishizaka, Takayuki, Kasai, Hitoshi

    High Performance Polymers - Polyimides Based - from Chemistry to Applications　2012

    DOI： 10.5772/53458 　

  84. Fabrication technique of organic nanocrystals and their optical properties and materialization Peer-reviewed

    Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Nanoparticle Technology Handbook　596-601　2012

    Publisher: Elsevier

    DOI： 10.1016/B978-0-444-56336-1.50055-2 　

  85. Cyclic transformation in shape and crystal structure of C-60 microcrystals Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Masataka Ikeshima, Toshimitsu Sato, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    CRYSTENGCOMM　14　(22)　7787-7791　2012

    DOI： 10.1039/c2ce25798j 　

    ISSN： 1466-8033

  86. Direct deposition of two nanomaterials with the same surface charge using a liquid-liquid interface Peer-reviewed

    Jun Matsui, Toshiaki Shibata, Takahiro Yokoyama, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Tokuji Miyashita

    NANOSCALE　4　(13)　3857-3860　2012

    DOI： 10.1039/c2nr30858d 　

    ISSN： 2040-3364

  87. Fabrication of doped Cu-TCNQ nanocrystals and their optoelectronic properties Peer-reviewed

    Tsunenobu Onodera, Satomi Matsuo, Kentaro Hiraishi, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa

    CRYSTENGCOMM　14　(22)　7586-7589　2012

    DOI： 10.1039/c2ce25926e 　

    ISSN： 1466-8033

  88. Creation of Pure Nanodrugs and Their Anticancer Properties Peer-reviewed

    Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　51　(41)　10315-10318　2012

    DOI： 10.1002/anie.201204596 　

    ISSN： 1433-7851

  89. Relationship between the Surface Morphology and Optical Property of Organic Nanocrystals Peer-reviewed

    Eunsang Kwon, Hae-Ryong Chung, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　566　(1)　147-150　2012

    DOI： 10.1080/15421406.2012.701877 　

    ISSN： 1542-1406

  90. Silver Nanoparticles-Accelerated Photopolymerization of a Diacetylene Derivative Peer-reviewed

    Takahiro Yokoyama, Akito Masuhara, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    JOURNAL OF PHYSICAL CHEMISTRY C　115　(45)　22121-22125　2011/11

    DOI： 10.1021/jp2039288 　

    ISSN： 1932-7447

  91. Fabrication and characterization of C60 fine crystals and their hybridization Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Fullerene Nanowhiskers　89-101　2011/09/30

    Publisher: Pan Stanford Publishing Pte. Ltd.

    DOI： 10.4032/9789814241632 　

  92. A method for enhancing the ocular penetration of eye drops using nanoparticles of hydrolyzable dye Peer-reviewed

    Koichi Baba, Yuji Tanaka, Akira Kubota, Hitoshi Kasai, Shunji Yokokura, Hachiro Nakanishi, Kohji Nishida

    JOURNAL OF CONTROLLED RELEASE　153　(3)　278-287　2011/08

    DOI： 10.1016/j.jconrel.2011.04.019 　

    ISSN： 0168-3659

    eISSN： 1873-4995

  93. Radical-Initiator-Induced Solid-State Polymerization of Butadiyne Nanocrystals in Water and Their Dispersion Stabilization Peer-reviewed

    Shuhei Kato, Takahiro Kinemuchi, Yoko Tatewaki, Shuji Okada, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　11　(4)　3340-3344　2011/04

    DOI： 10.1166/jnn.2011.4165 　

    ISSN： 1533-4880

  94. Poly(N-isopropylacrylamide)-Based Thermoresponsive Behavior of Fluorescent Organic Nanocrystals Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Kohji Nishida, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　50　(1)　1-3　2011/01

    DOI： 10.1143/JJAP.50.010202 　

    ISSN： 0021-4922

  95. Nanocrystallization Process of Diarylethene Peer-reviewed

    Norio Tagawa, Akito Masuhara, Tsunenobu Onodera, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　539　(539)　45-49　2011

    DOI： 10.1080/15421406.2011.566050 　

    ISSN： 1542-1406

  96. Polystyrene-encapsulated diarylethene nanocrystals by soap-free emulsion polymerization Peer-reviewed

    Norio Tagawa, Akito Masuhara, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    JOURNAL OF MATERIALS CHEMISTRY　21　(22)　7892-7894　2011

    DOI： 10.1039/c1jm11415h 　

    ISSN： 0959-9428

  97. Assembly of Fullerene Nanoparticles Using a Liquid-Liquid Interface Peer-reviewed

    Rinko Kudo, Jun Matsui, Takahiro Yokoyama, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Tokuji Miyashita

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　539　68-72　2011

    DOI： 10.1080/15421406.2011.566059 　

    ISSN： 1542-1406

  98. Plasmon-Enhanced Photopolymerization of SU-8 on Rough Gold Surfaces Peer-reviewed

    Takahiro Yokoyama, Akito Masuhara, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    JOURNAL OF PHYSICAL CHEMISTRY C　114　(46)　19596-19599　2010/11

    DOI： 10.1021/jp106263h 　

    ISSN： 1932-7447

  99. Nanocrystallization of Diarylethene and Photochromic Properties Peer-reviewed

    Norio Tagawa, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    CRYSTAL GROWTH & DESIGN　10　(7)　2857-2859　2010/07

    DOI： 10.1021/cg100441h 　

    ISSN： 1528-7483

    eISSN： 1528-7505

  100. Fabrication of Nanocrystals from Diolefin Derivatives and Their Solid-State Photoreaction Behavior Peer-reviewed

    Hirohiko Miura, Shu Takahashi, Hitoshi Kasai, Shuji Okada, Kiyoshi Yase, Hidetoshi Oikawa, Hachiro Nakanishi

    CRYSTAL GROWTH & DESIGN　10　(2)　510-517　2010/02

    DOI： 10.1021/cg900511z 　

    ISSN： 1528-7483

    eISSN： 1528-7505

  101. Monodispersed and Size-Controlled Diarylethene Nanoparticles Fabricated by the Reprecipitation Method Peer-reviewed

    Norio Tagawa, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　520　521-526　2010

    DOI： 10.1080/15421400903584549 　

    ISSN： 1542-1406

  102. Using an organic additive to manipulate sizes of perylene nanoparticles Peer-reviewed

    Daniel Oliveira, Koichi Baba, Junichi Mori, Yousuke Miyashita, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JOURNAL OF CRYSTAL GROWTH　312　(3)　431-436　2010/01

    DOI： 10.1016/j.jcrysgro.2009.11.028 　

    ISSN： 0022-0248

    eISSN： 1873-5002

  103. Optical and Electrical Properties of Size-Controlled Cu-7,7 ',8,8 '-Tetracyanoquinodimethane Nanocrystals Peer-reviewed

    Kentaro Hiraishi, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    JAPANESE JOURNAL OF APPLIED PHYSICS　49　(1)　1-4　2010

    DOI： 10.1143/JJAP.49.01AE08 　

    ISSN： 0021-4922

  104. New Class Materials of Organic-Inorganic Hybridized Nanocrystals/Nanoparticles, and Their Assembled Micro- and Nano-Structure Toward Photonics Peer-reviewed

    Hidetoshi Oikawa, Tsunenobu Onodera, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi

    POLYMER MATERIALS: BLOCK-COPOLYMERS, NANOCOMPOSITES, ORGANIC/INORGANIC HYBRIDS, POLYMETHYLENES　231　(231)　147-190　2010

    DOI： 10.1007/12_2009_19 　

    ISSN： 0065-3195

  105. Organic Solvent-Free Fluorescence Confocal Imaging of Living Cells Using Pure Nanocrystal Forms of Fluorescent Dyes Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Akito Masuhara, Hidetoshi Oikawa, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　48　(11)　117002　2009/11

    DOI： 10.1143/JJAP.48.117002 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  106. Nanocrystallization Mechanism of Organic Compounds in the Reprecipitation Method by Stopped-Flow Analysis Peer-reviewed

    Daniel Oliveira, Koichi Baba, Junichi Mori, Yousuke Miyashita, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　48　(10)　105003　2009/10

    DOI： 10.1143/JJAP.48.105003 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  107. Nanostructural characterization and catalytic analysis of hybridized platinum/phthalocyanine nanocomposites Peer-reviewed

    Kenji Kaneko, Kazuki Furuya, Ana B. Hungria, Juan-Carlos Hernandez-Garrido, Paul A. Midgley, Tsunenobu Onodera, Hitoshi Kasai, Yusuke Yaguchi, Hidetoshi Oikawa, Yohei Nomura, Hiroki Harada, Tatsumi Ishihara, Norio Baba

    JOURNAL OF ELECTRON MICROSCOPY　58　(5)　289-294　2009/10

    DOI： 10.1093/jmicro/dfp027 　

    ISSN： 0022-0744

  108. Fullerene Fine Crystals with Unique Shapes and Controlled Size Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    JAPANESE JOURNAL OF APPLIED PHYSICS　48　(5)　050206　2009/05

    DOI： 10.1143/JJAP.48.050206 　

    ISSN： 0021-4922

  109. Single-photon emission from a single nanoparticle consisting of a single conjugated polymer chain Peer-reviewed

    Sadahiro Masuo, Tomoya Tanaka, Takumi Murakami, Akito Masuhara, Shinjiro Machida, Hitoshi Kasai, Hidetoshi Oikawa, Akira Itaya

    SYNTHETIC METALS　159　(9-10)　805-808　2009/05

    DOI： 10.1016/j.synthmet.2009.01.009 　

    ISSN： 0379-6779

  110. Development of fabrication process for Ag/polydiacetylene (core/shell) hybridized nanocrystals Peer-reviewed

    Takahiro Yokoyama, Akito Masuhara, Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa

    SYNTHETIC METALS　159　(9-10)　897-899　2009/05

    DOI： 10.1016/j.synthmet.2009.01.058 　

    ISSN： 0379-6779

  111. Densely packed organic nanocrystals ultrathin film using a liquid-liquid interface Peer-reviewed

    J. Matsui, T. Shibata, K. Yamamoto, T. Yokoyama, A. Masuhara, H. Kasai, H. Oikawa, T. Miyashita

    SYNTHETIC METALS　159　(9-10)　847-850　2009/05

    DOI： 10.1016/j.synthmet.2009.01.025 　

    ISSN： 0379-6779

  112. Fabrication and characterization of size-controlled CuTCNQ charge-transfer complex nanocrystals Peer-reviewed

    Kentaro Hiraishi, Akito Masuhara, Takahiro Yokoyama, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    JOURNAL OF CRYSTAL GROWTH　311　(3)　948-952　2009/01

    DOI： 10.1016/j.jcrysgro.2008.09.158 　

    ISSN： 0022-0248

    eISSN： 1873-5002

  113. Ultralow-Dielectric-Constant Films Prepared from Hollow Polyimide Nanoparticles Possessing Controllable Core Sizes Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Masatoshi Hasegawa, Takeo Furukawa, Hachiro Nakanishi, Hidetoshi Oikawa

    CHEMISTRY OF MATERIALS　21　(2)　419-424　2009/01

    DOI： 10.1021/cm802989u 　

    ISSN： 0897-4756

  114. Hybridization of polydiacetylene core and metal shell Peer-reviewed

    T. Onodera, J. Ujita, D. Ishikawa, A. Masuhara, H. Kasai, H. Oikawa

    ECS Transactions　16　(33)　1-12　2009

    DOI： 10.1149/1.3095821 　

    ISSN： 1938-5862 1938-6737

  115. Excited-states and lightfastness of linear trans-quinacridone pigment nanoparticles Peer-reviewed

    Yousuke Miyashita, Hiroshi Yokoyama, Mamoru Tanabe, Hitoshi Kasai, Hachiro Nakanishi, Tokuji Miyashita

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY　201　(2-3)　208-213　2009/01

    DOI： 10.1016/j.jphotochem.2008.10.024 　

    ISSN： 1010-6030

  116. Using a polyelectrolyte to fabricate porous polyimide nanoparticles with crater-like pores Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Masatoshi Hasegawa, Hachiro Nakanishi, Hidetoshi Oikawa

    POLYMERS FOR ADVANCED TECHNOLOGIES　20　(1)　43-47　2009/01

    DOI： 10.1002/pat.1278 　

    ISSN： 1042-7147

  117. Fabrication and luminescence properties of Eu-complex/polyimide composite nanoparticles Peer-reviewed

    Takayuki Ishizaka, Hitoshi Kasai, Hachiro Nakanishi

    JOURNAL OF MATERIALS SCIENCE　44　(1)　166-169　2009/01

    DOI： 10.1007/s10853-008-3110-3 　

    ISSN： 0022-2461

    eISSN： 1573-4803

  118. Stopped-flow analysis on the mechanism of perylene nanoparticle formation by the reprecipitation method Peer-reviewed

    Junichi Mori, Yousuke Miyashita, Daniel Oliveira, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JOURNAL OF CRYSTAL GROWTH　311　(3)　553-555　2009/01

    DOI： 10.1016/j.jcrysgro.2008.09.038 　

    ISSN： 0022-0248

  119. Anomalous Polyimide Nanoparticles Prepared from Blending of Unlike Polymers Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Masatoshi Hasegawa, Hachiro Nakanishi, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　504　(504)　9-17　2009

    DOI： 10.1080/15421400902938951 　

    ISSN： 1542-1406

  120. Recent Progress in Our Studies on Organic Nanocrystals Peer-reviewed

    Hachiro Nakanishi, Hidetoshi Oikawa, Hitoshi Kasai, Akito Masuhara, Tsunenobu Onodera, Jun-ichi Mori, Yousuke Miyashita

    Nonlinear Optics and Quantum Optics　38　(3)　297-308　2009/01

  121. Fabrication of Porous Nanoscale Polyimide Structures Peer-reviewed

    Hitoshi Kasai, Hideharu Mitsui, Gufan Zhao, Takayuki Ishizaka, Masao Suzuki, Hidetoshi Oikawa, Hachiro Nakanishi

    CHEMISTRY LETTERS　37　(10)　1056-1057　2008/10

    DOI： 10.1246/cl.2008.1056 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  122. Introducing porosity into polyimide nanoparticles Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　8　(6)　3171-3175　2008/06

    DOI： 10.1166/jnn.2008.074 　

    ISSN： 1533-4880

  123. Crystallization Process of Organic Nanocrystals Peer-reviewed

    Eunsang Kwon, Kento Ujiiye-Ishii, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    The 4th Asian Conference on Crystal Growth and Crystal Technology　2008/05

  124. Chemical Doping into Nanocrystals of Poly(diacetylene) Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Yoshikazu Shinohara, Shuji Okada, Hidetoshi Oikawa, Hiro Matsuda, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS　47　(5)　3769-3771　2008/05

    DOI： 10.1143/JJAP.47.3769 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  125. Size-dependent fluorescence spectra of individual perylene nanocrystals studied by far-field fluorescence microspectroscopy coupled with atomic force microscope observation Peer-reviewed

    T. Asahi, H. Matsune, K. Yamashita, H. Masuhara, H. Kasai, H. Nakanishi

    POLISH JOURNAL OF CHEMISTRY　82　(4)　687-699　2008/04

    ISSN： 0137-5083

  126. Organic Nanocrystal Fabrication by the Emulsion Method Peer-reviewed

    Kento Ujiiye-Ishii, Eunsang Kwon, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    The 8th International Symposium on Advanced Organic Photonics (ISAOP-8)　2008/02

  127. Methodological features of the emulsion and reprecipitation methods for organic nanocrystal fabrication Peer-reviewed

    Kento Ujiiye-Ishii, Eunsang Kwon, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    CRYSTAL GROWTH & DESIGN　8　(2)　369-371　2008/02

    DOI： 10.1021/cg700708g 　

    ISSN： 1528-7483

  128. Multibranched C-60 micro/nanocrystals fabricated by reprecipitation method Peer-reviewed

    Zhenquan Tan, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    JAPANESE JOURNAL OF APPLIED PHYSICS　47　(2)　1426-1428　2008/02

    DOI： 10.1143/JJAP.47.1426 　

    ISSN： 0021-4922

  129. A new model system for studying excited states of dye aggregates of photographic color paper Peer-reviewed

    Yousuke Miyashita, Junichi Mori, Hiroshi Yokoyama, Mitsuo Yoshikane, Hiroyuki Watanabe, Kiyoshi Takeuchi, Hitoshi Kasai, Hachiro Nakanishi, Tokuji Miyashita

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY　194　(2-3)　129-135　2008/02

    DOI： 10.1016/j.jphotochem.2007.07.025 　

    ISSN： 1010-6030

  130. 再沈法によるポリイミドナノ粒子の作製及び形態制御 Peer-reviewed

    石坂 孝之, 趙 汨凡, 笠井 均, 川波 肇, 横山 敏郎, 及川 英俊, 中西 八郎

    化学工学会 研究発表講演要旨集　2008　610-610　2008

    Publisher: 公益社団法人 化学工学会

    DOI： 10.11491/scej.2008f.0.610.0 　

  131. Size-controlled production of quinacridone nanocrystals using hot compressed water recrystallization method Peer-reviewed

    Kiwarnu Sue, Toshihiko Usami, Kunio Arai, Hitoshi Kasai, Hachiro Nakanishi, Toshihiko Hiaki

    DYES AND PIGMENTS　76　(3)　632-635　2008

    DOI： 10.1016/j.dyepig.2006.12.002 　

    ISSN： 0143-7208

  132. Fabrication and Characterization of Size- and Shape-Controlled C60 Nano/microcrystals by Solvent-Induced Reprecipitation Process (SIRP) Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Materials Research Society Symposia Proceedings　1054　(FF11)　FF11-09　2008

    DOI： 10.1557/PROC-1054-FF11-09 　

    More details Close

    5254

  133. A New Production Process of Organic Pigment Nanocrystals Peer-reviewed

    Yousuke Miyashita, Koichi Baba, Hitoshi Kasai, Hachiro Nakanishi, Tokuji Miyashita

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　492　268-274　2008

    DOI： 10.1080/15421400802330606 　

    ISSN： 1542-1406

  134. A Convinient Method to Prepare Gold-Coated C-60 Nanocrystals Peer-reviewed

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　492　262-267　2008

    DOI： 10.1080/15421400802330523 　

    ISSN： 1542-1406

  135. Nanocrystal Fabrication of Acrylic Acid Derivatives with a Long-Alkyl Group and Their Solid-State Polymerization Peer-reviewed

    Hitoshi Abe, Shuji Okada, Tatsumi Kimura, Satoru Shimada, Hiro Matsuda, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　492　70-76　2008

    DOI： 10.1080/15421400802333444 　

    ISSN： 1542-1406

  136. External field-induced orientation of DAST naocrystals in the dispersion state and the fixation Peer-reviewed

    H. Kasai, Y. Kaneko, T. Onodera, H. Nakanishi, H. Oikawa, S. Okada, S. Shimada, T. Kimura, H. Matsuda

    ORGANIC PHOTONIC MATERIALS AND DEVICES X　6891　(689114)　689114-1-689114-6　2008

    DOI： 10.1117/12.771177 　

    ISSN： 0277-786X

  137. Diacetylene nanowire crystals prepared by reprecipitation/microwave-irradiation method Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Akito Masuhara, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS　46　(11)　7558-7561　2007/11

    DOI： 10.1143/JJAP.46.7558 　

    ISSN： 0021-4922

  138. Anisotropic orientation control of nonpolar organic nanocrystal dispersion by external fields Peer-reviewed

    Yuji Kaneko, Satoru Shimadai, Tsunenobu Onodera, Tatsumi Kimura, Hiro Matsuda, Shuji Okada, Hitoshi Kasai, Hidetoshi Oikawa, Yozo Kakudate, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS　46　(10A)　6893-6897　2007/10

    DOI： 10.1143/JJAP.46.6893 　

    ISSN： 0021-4922

  139. Fabrication of size-controlled polyimide nanoparticles Peer-reviewed

    M. Suzuki, H. Kasai, T. Ishizaka, H. Miura, S. Okada, H. Oikawa, T. Nihira, H. Fukuro, H. Nakanishi

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　7　(8)　2748-2752　2007/08

    DOI： 10.1166/jnn.2007.603 　

    ISSN： 1533-4880

  140. Surface structure effect on optical properties of organic nanocrystals Peer-reviewed

    E. Kwon, H.-R. Chung, Y. Araki, H. Kasai, H. Oikawa, O. Ito, H. Nakanishi

    CHEMICAL PHYSICS LETTERS　441　(1-3)　106-108　2007/06

    DOI： 10.1016/j.cplett.2007.04.081 　

    ISSN： 0009-2614

    eISSN： 1873-4448

  141. Quinacridone solubility in hot-compressed water Peer-reviewed

    Kiwamu Sue, Toshihiko Usami, Kunio Arai, Hitoshi Kasai, Hachiro Nakanishi, Toshihiko Hiaki

    JOURNAL OF CHEMICAL AND ENGINEERING DATA　52　(3)　714-717　2007/05

    DOI： 10.1021/je060466i 　

    ISSN： 0021-9568

  142. Fabrication of unique porous polyimide nanoparticles using a reprecipitation method Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    CHEMISTRY OF MATERIALS　19　(8)　1901-1905　2007/04

    DOI： 10.1021/cm062709w 　

    ISSN： 0897-4756

  143. A fabrication method of organic nanocrystals using stabilizer-free emulsion Peer-reviewed

    Eunsang Kwon, Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    CRYSTAL GROWTH & DESIGN　7　(4)　600-602　2007/04

    DOI： 10.1021/cg0607349 　

    ISSN： 1528-7483

    eISSN： 1528-7505

  144. Photon antibunching in the emission from a single organic dye nanocrystal Peer-reviewed

    Sadahiro Masuo, Akito Masuhara, Takeaki Akashi, Mai Muranushi, Shinjiro Machida, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa, Akira Itaya

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　46　(12-16)　L268-L270　2007/04

    DOI： 10.1143/JJAP.46.L268 　

    ISSN： 0021-4922

  145. Silver-deposited polydiacetylene nanocrystals produced by visible-light-driven photocatalytic reduction Peer-reviewed

    Tsunenobu Onodera, Hidetoshi Oikawa, Akito Masuhara, Hitoshi Kasai, Takashi Sekiguchi, Hachiro Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　46　(12-16)　L336-L338　2007/04

    DOI： 10.1143/JJAP.46.L336 　

    ISSN： 0021-4922

  146. Size control for fullerene C-60 nanocrystals during the high temperature and high pressure fluid crystallization process Peer-reviewed

    Bo Li, Xutang Tao, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    MATERIALS LETTERS　61　(8-9)　1738-1741　2007/04

    DOI： 10.1016/j.matlet.2006.07.121 　

    ISSN： 0167-577X

  147. Preparation of multilayered film of polyimide nanoparticles for low-k applications Peer-reviewed

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　464　613-620　2007/03

    DOI： 10.1080/15421400601028476 　

    ISSN： 1542-1406

  148. In situ and ex situ observations of the growth dynamics of single perylene nanocrystals in water Peer-reviewed

    Takashi Tachikawa, Hae-Ryong Chung, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi, Mamoru Fujitsuka, Tetsuro Majima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　128　(50)　15944-15945　2006/12

    DOI： 10.1021/ja0654276 　

    ISSN： 0002-7863

  149. Unique luminescence properties of Eu3+-doped polyimide Peer-reviewed

    Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY　183　(3)　280-284　2006/10

    DOI： 10.1016/j.jphotochem.2006.06.033 　

    ISSN： 1010-6030

  150. Effect of solvent on organic nanocrystal growth using the reprecipitation method Peer-reviewed

    Hae-Ryong Chung, Eunsang Kwon, Hidetoshi Kawa, Hitoshi Kasai, Hachiro Nakanishi

    JOURNAL OF CRYSTAL GROWTH　294　(2)　459-463　2006/09

    DOI： 10.1016/j.jcrysgro.2006.07.010 　

    ISSN： 0022-0248

  151. Solid-state polymerization behavior of 1,3-bis(3-quinolyl)-1,4-butadiyne Peer-reviewed

    Tiesheng Li, Shuji Okada, Hirohito Umezawa, Hitoshi Kasai, Hachiro Nakanishi, Satya S. Talwar, Tatsumi Kimura, Hiro Matsuda

    POLYMER BULLETIN　57　(5)　737-746　2006/09

    DOI： 10.1007/s00289-006-0626-z 　

    ISSN： 0170-0839

  152. Size and Shape Controlled Polydiacetylene Nanocrystals Prepared by Using Microwave Irradiation Effect in the Reprecipitation Method Peer-reviewed

    Akito Masuhara, Koichi Baba, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa, Shuji Okada

    40th International Microwave Symposium Proceedings　225-227　2006/08

  153. Fabrication of multilayered film of polyimide nanoparticles for low-k applications

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(2)　3815-3816　2006

  154. Unique luminescence properties of rare earth ion-doped polyimide nanoparticles and its mechanism

    Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(2)　4121　2006

  155. Fabrication of Eu complex-polyimide composite nanoparticles

    Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(2)　4125　2006

  156. Investigation of thermoelectric properties of polythiophene synthesized by electrolytic polymerization

    Kentaro Hiraishi, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi, Yoshikazu Shinohara, Yoshio Imai, Yukihiro Isoda

    Polymer Preprints, Japan　55　(2)　3990　2006

  157. Fabrication and C60 nanocrystals with several morphology

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hachiro Nakanishi, Hidetoshi Oikawa

    Polymer Preprints, Japan　55　(2)　3415　2006

  158. Fabrication of polydiacetylene nanocrystals with metal nanoshells - Photo-catalytic reduction and optical properties

    Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(1)　1413　2006

  159. Investigation of unique luminescence phenomena of rare earth ion-doped polyimide nanoparticles

    Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(1)　1522　2006

  160. Morphology control and characterization of porous polyimide nanoparticles

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(1)　1267　2006

  161. Fabrication of hybridized C60 core -Au shell structured nanocrystals

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　55　(1)　1280　2006

  162. Test strips for heavy-metal ions fabricated from nanosized dye compounds Peer-reviewed

    Y Takahashi, H Kasai, H Nakanishi, TM Suzuki

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　45　(6)　913-916　2006

    DOI： 10.1002/anie.200503015 　

    ISSN： 1433-7851

  163. Continuous production of quinacridone nanocrystals and control of crystal form by high-temperature water crystallization method Peer-reviewed

    K Sue, T Usami, K Arai, H Kasai, H Nakanishi, T Hiaki

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS　45　(1B)　375-378　2006/01

    DOI： 10.1143/JJAP.45.375 　

    ISSN： 0021-4922

  164. Silver-coated polydiacetylene nanocrystals fabricated using Surfactants as binder Peer-reviewed

    T Onodera, ZQ Tan, A Masuhara, H Oikawa, H Kasai, H Nakanishi, T Sekiguchi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS　45　(1B)　379-383　2006/01

    DOI： 10.1143/JJAP.45.379 　

    ISSN： 0021-4922

  165. Fabrication of diacetylene nanofibers and their dynamic behavior in the course of solid-state polymerization Peer-reviewed

    K Baba, H Kasai, S Okada, H Nakanishi, H Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　445　161-166　2006

    DOI： 10.1080/15421400500367066 　

    ISSN： 1542-1406

  166. Mass-production of pigment nanocrystals by the reprecipitation method and their encapsulation Peer-reviewed

    K Ujiiye-Ishii, K Baba, Z Wei, H Kasai, H Nakanishi, S Okada, H Oikawa

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　445　177-183　2006

    DOI： 10.1080/15421400500367082 　

    ISSN： 1542-1406

  167. All-optical switching potentiality in Fabry-Perot devices containing poly-DCHD Peer-reviewed

    MA Camacho, AK Kar, BS Wherrett, M Bakarezos, R Rangel-Rojo, S Yamada, H Matsuda, H Kasai, H Nakanishi

    OPTICS COMMUNICATIONS　251　(4-6)　376-387　2005/07

    DOI： 10.1016/j.optcom.2005.03.015 　

    ISSN： 0030-4018

  168. Synthesis and characterization of monodispersed polymer/polydiacetylene nanocrystal composite particles Peer-reviewed

    Z Wei, K Ujiiye-Ishii, A Masuhara, H Kasai, S Okada, H Matsune, T Asahi, H Masuhara, H Nakanishi

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　5　(6)　937-944　2005/06

    DOI： 10.1166/jnn.2005.121 　

    ISSN： 1533-4880

  169. Optoelectronic Interfacial interaction in Metal-Polydiacetylene Hybridized Nanocrystals Peer-reviewed

    Hidetoshi Oikawa, Aurel M. Vlaicu, Masahiro Kimura, Hideki Yoshikawa, Shigeo Tanuma, Akito Masuhara, Hitoshi Kasai, Hachiro Nakanishi

    Nonlinear Optics, Quantum Optics　34　275-278　2005/04

  170. Fabrication of hybridized nanocrystals composed of π-conjugated polymers involving metal nanoparticles

    Akito Masuhara, Tan Zhenquan, Hitoshi Kasai, Yoshikazu Shinohara, Shuii Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(1)　1660　2005

  171. Fabrication of organic nanocrystals by microwave irradiation

    Satoko Maenishi, Koichi Baba, Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(1)　1210　2005

  172. Fabrication of porous polyimide nanoparticles and their multilayered film

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(1)　961　2005

  173. Unique luminescence properties of rare earth ion-doped polyimide nanoparticles and investigation of their mechanism

    Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(2)　4422-4423　2005

  174. Fabrication and optical properties of super structured hetero thin films composed of metal nanoparticles and PDA nanocrystals

    Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(2)　4420-4421　2005

  175. Fabrication of porous polyimide nanoparticles with controllable morphology

    Gufan Zhao, Takayuki Ishizaka, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Polymer Preprints, Japan　54　(2)　2995-2996　2005

  176. Structure effect to thermoelectric properties of polythiophene synthesized by electrolytic polymerization

    Kentaro Hiraishi, Hidetoshi Oikawa, Hitoshi Kasai, Akito Masuhara, Hachiro Nakanishi, Yoshikazu Shinohara, Shuji Okada

    Polymer Preprints, Japan　54　(2)　2879-2880　2005

  177. 超臨界再沈法によるナノサイズ有機微結晶の作製に関する研究 Peer-reviewed

    宇佐見 俊彦, 陶 究, 新井 邦夫, 笠井 均, 中西 八郎

    化学工学会 研究発表講演要旨集　2005　115-115　2005

    Publisher: 公益社団法人 化学工学会

    DOI： 10.11491/scej.2005.0.115.0 　

  178. A novel method for fixing the anisotropic orientation of dispersed organic nanocrystals in a magnetic field Peer-reviewed

    Y Kaneko, S Shimada, T Fukuda, T Kimura, H Yokoi, H Matsuda, T Onodera, H Kasai, S Okada, H Oikawa, H Nakanishi

    ADVANCED MATERIALS　17　(2)　160-+　2005/01

    DOI： 10.1002/adma.200400275 　

    ISSN： 0935-9648

  179. Reversible and efficient anisotropic orientation of dispersed aromatic hydrocarbon nanocrystals in a magnetic field Peer-reviewed

    Y Kaneko, T Onodera, H Kasai, S Okada, H Oikawa, H Nakanishi, T Fukuda, H Matsuda

    JOURNAL OF MATERIALS CHEMISTRY　15　(2)　253-255　2005/01

    DOI： 10.1039/b412351d 　

    ISSN： 0959-9428

  180. Study of a poly-1,6-dicarbazolyl-2,4-hexadiyne nanocrystal film by the fifth-order electroabsorption spectroscopy Peer-reviewed

    Ke Yang, Jin-An He, Jayant Kumar, Lynne A. Samuelson, Toshiyuki Oshikiri, Hideyuki Katagi, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi, Suukant K. Tripathy

    Journal of the Optical Society of America B: Optical Physics　22　(3)　623-632　2005

    Publisher: Optical Society of American (OSA)

    DOI： 10.1364/JOSAB.22.000623 　

    ISSN： 0740-3224

  181. Fabrication of polydiacetylene nanocrystals deposited with silver nanoparticles for a nonlinear optical material Peer-reviewed

    T Onodera, H Oikawa, H Kasai, H Nakanishi, T Sekiguchi

    Organic and Nanocomposite Optical Materials　846　257-262　2005

    ISSN： 0272-9172

  182. Size-effect on fluorescence spectrum of perylene nanocrystal studied by single-particle microspectroscopy coupled with atomic force microscope observation Peer-reviewed

    H Matsune, T Asahi, H Masuhara, H Kasai, H Nakanishi

    Organic and Nanocomposite Optical Materials　846　263-268　2005

    ISSN： 0272-9172

  183. Titanyl phthalocyanine solubility in supercritical acetone Peer-reviewed

    K Sue, T Mizutani, T Usami, K Arai, H Kasai, H Nakanishi

    JOURNAL OF SUPERCRITICAL FLUIDS　30　(3)　281-285　2004/08

    DOI： 10.1016/j.supflu.2003.09.008 　

    ISSN： 0896-8446

  184. Size-dependent optical properties of polydiacetylene nanocrystal Peer-reviewed

    VV Volkov, T Asahi, H Masuhara, A Masuhara, H Kasai, H Oikawa, H Nakanishi

    JOURNAL OF PHYSICAL CHEMISTRY B　108　(23)　7674-7680　2004/06

    DOI： 10.1021/jp031369o 　

    ISSN： 1520-6106

  185. Intensity-controllable luminescence of Eu3+-doped polyimide nanoparticles by UV irradiation and heat-treatment Peer-reviewed

    T Ishizaka, H Kasai, H Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　43　(4B)　L516-L518　2004/04

    DOI： 10.1143/JJAP.43.L516 　

    ISSN： 0021-4922

  186. Control of Luminescence Intensity from Eu3+-doped Polyimide Nanoparticles by UV-irradiation and Thermal Treatment Peer-reviewed

    Takayuki Ishizaka, Hitoshi Kasai, Hachiro Nakanishi

    Transactions of the Materials Research Society of Japan　29　(5)　2117-2119　2004/04

  187. Fabrication and Optical Properties of Nanocomplexes Composed of Metal Nanoparticles and Organic Dyes Peer-reviewed

    Akito Masuhara, Satoshi Ohhashi, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Journal of Nonlinear Optical Physics and Materials　13　(3&4)　587-592　2004/04

    DOI： 10.1142/S021886350400233X 　

  188. 新しい材料体系を目指した有機#Sc#SR高分子ナノ結晶の創製 Peer-reviewed

    及川英俊, 増原陽人, 大橋諭, 笠井均, 中西八郎

    表面科学　25　170-176　2004/04

  189. ハイブリッド系有機-金属ナノ結晶における光#Sc#SR電子界面相互作用 Peer-reviewed

    及川英俊, 増原陽人, 大橋諭, 笠井均, 岡田修司, 中西八郎

    表面科学　25　(3)　48-54　2004/04

    Publisher: The Surface Science Society of Japan

    DOI： 10.1380/jsssj.25.170 　

    ISSN： 0388-5321

    More details Close

    Hybridized nanocrystals, which were composed of polydiacetylene (PDA) nanocrystal as a shell layer and silver nano-particle as a core part, were successfully fabricated by means of the "co-reprecipitation method" and the subsequent UV-irradiation to convert the shell layer of solid-state polymerizable diacetylene into PDA. The hybridized core-shell type structure was investigated using both SEM and TEM observations. Interestingly, the plasmon absorption peak of silver nanoparticle decreased and apparently disappeared during UV-irradiation for solid-state polymerization, while the excitonic absorption peak from π-conjugation of PDA was remarkably red-shifted at the same time, compared with only PDA nanocrystal having the same crystal size as the hybridized nanocrystal. These facts suggest that silver nanoparticle of core part may interact optoelectronically with the shell layer of PDA in hybridized nanocrystals to provide different electron states from the original materials.

  190. Control of luminescence intensity from rare earth ion (Eu3+, Tu(3+))-doped polyimide nanoparticles by UV-irradiation and thermal treatment Peer-reviewed

    T Ishizaka, H Kasai, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　424　103-110　2004

    DOI： 10.1080/15421400490505956 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  191. Chapter 13 Organic and polymer nanocrystals: Their optical properties and function Peer-reviewed

    H. Oikawa, A. Masuhara, H. Kasai, T. Mitsui, T. Sekiguchi, H. Nakanishi

    Handai Nanophotonics　1　(C)　205-224　2004

    DOI： 10.1016/S1574-0641(04)80018-4 　

    ISSN： 1574-0641

  192. Orientation of suspended polar organic nanocrystals in magnetic fields: Effect of magnetic field configuration Peer-reviewed

    Y Kaneko, T Fukuda, T Onodera, H Kasai, S Okada, H Oikawa, H Nakanishi, H Matsuda

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　42　(11A)　L1343-L1345　2003/11

    DOI： 10.1143/JJAP.42.L1343 　

    ISSN： 0021-4922

  193. Monodispersed polydiacetylene-polystyrene composite particles Peer-reviewed

    Z Wei, H Miura, A Masuhara, H Kasai, S Okada, H Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　42　(10A)　L1213-L1215　2003/10

    DOI： 10.1143/JJAP.42.L1213 　

    ISSN： 0021-4922

  194. Monodispersed quinacridone nanocrystals prepared by a high-temperature and high-pressure liquid crystallization method Peer-reviewed

    B Li, H Kasai, H Oikawa, S Okada, K Arai, H Nakanishi

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY　3　(5)　365-367　2003/10

    DOI： 10.1166/jnn.2003.215 　

    ISSN： 1533-4880

  195. Crystal size dependence of fluorescence spectra from perylene nanocrystals evaluated by scanning near-field optical microspectroscopy Peer-reviewed

    H Oikawa, T Mitsui, T Onodera, H Kasai, H Nakanishi, T Sekiguchi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　42　(2A)　L111-L113　2003/02

    DOI： 10.1143/JJAP.42.L111 　

    ISSN： 0021-4922

  196. Preparation of polyimide ultrafine particles Peer-reviewed

    Masao Suzuki, Hitoshi Kasai, Hirohiko Miura, Shuji Okada, Hachiro Nakanishi, Hidetoshi Oikawa, Takayasu Nihira, Hiroyoshi Fukuro

    Molecular Crystals and Liquid Crystals　406　151-157　2003

    Publisher: Taylor and Francis Inc.

    DOI： 10.1080/744818998 　

    ISSN： 1542-1406

  197. AC electric-field-induced orientation of polar organic nanocrystal in disperse system Peer-reviewed

    T Onodera, M Yoshida, S Okazoe, S Fujita, H Kasai, S Okada, H Oikawa, H Nakanishi

    ASIANANO 2002, PROCEEDINGS　363-367　2003

  198. Fabrication and characterization of quinacridones nanocrystals by high-temperature and high-pressure crystallization method Peer-reviewed

    B Li, H Kasai, H Oikawa, S Okada, K Arai, H Nakanishi

    ASIANANO 2002, PROCEEDINGS　1　(5&6)　213-218　2003

    DOI： 10.1142/S0219581X02000711 　

  199. Fabrication of organic nanocrystals using microwave irradiation and their optical properties Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Optical Materials　21　(1-3)　591-594　2003/01

    DOI： 10.1016/S0925-3467(02)00206-9 　

    ISSN： 0925-3467

  200. Temperature- and size-effects on optical properties of perylene microcrystals Peer-reviewed

    Tsunenobu Onodera, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Ken-Ichi Mizuno, Mamoru Fujitsuka, Osamu Ito, Hachiro Nakanishi

    Optical Materials　21　(1-3)　595-598　2003/01

    DOI： 10.1016/S0925-3467(02)00207-0 　

    ISSN： 0925-3467

  201. Preparation of polyimide ultrafine particles Peer-reviewed

    M Suzuki, H Kasai, H Miura, S Okada, H Nakanishi, H Oikawa, T Nihira, H Fukuro

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　406　345-351　2003

    DOI： 10.1080/15421400390263226 　

    ISSN： 1058-725X

  202. Ultrafast nonlinearity in polydiacetylene microcrystals Peer-reviewed

    R Rangel-Rojo, H Matsuda, H Kasai, H Nakanishi

    OPTICS FOR THE QUALITY OF LIFE, PTS 1 AND 2　4829　(I)　396-396　2003

    DOI： 10.1117/12.525192 　

    ISSN： 0277-786X

  203. Preparation of Organic and Hybridized Nanocrystals for Photonics Peer-reviewed

    Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Nanotechnology toward the Organic Photonics　229-236　2002/11/01

  204. Single-crystal-to-single-crystal transformation of diolefin derivatives in nanocrystals Peer-reviewed

    S Takahashi, H Miura, H Kasai, S Okada, H Oikawa, H Nakanishi

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　124　(37)　10944-10945　2002/09

    DOI： 10.1021/ja026564f 　

    ISSN： 0002-7863

  205. STM observation of single molecular chains of π-conjugated polymers Peer-reviewed

    Hitoshi Kasai, Hiroyuki Tanaka, Shuji Okada, Hidetoshi Oikawa, Tomoji Kawai, Hachiro Nakanishi

    Chemistry Letters　7　(7)　696-697　2002/07/05

    Publisher: Chemical Society of Japan

    DOI： 10.1246/cl.2002.696 　

    ISSN： 0366-7022

  206. Nanotechnology toward the Organic Photonics Peer-reviewed

    Koichi Baba, Eiji Sarashina, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Goo Tech Ltd.　223-228　2002/04

  207. Fabrication and characterization of quinacridones nanocrystals by high-temperature and high-pressure crystallization method Peer-reviewed

    Bo Li, Hitoshi Kasai, Hidetoshi Oikawa, Shuji Okada, Kunio Arai, Hachiro Nakanishi

    International Journal of Nanoscience, Vol 1, Nos 5 and 6　1　(5-6)　587-592　2002

  208. Electric-field-induced orientation of polar organic nanocrystal in disperse system Peer-reviewed

    T. Onodera, M. Yoshida, S. Okazoe, S. Fujita, H. Kasai, S. Okada, H. Oikawa, H. Nakanishi

    International Journal of Nanoscience, Vol 1, Nos 5 and 6　1　(5-6)　737-741　2002

    DOI： 10.1142/9789812796714_0063 　

  209. Preparation of poly(amic acid) nanoparticles using the reprecipitation method and their imidization Peer-reviewed

    M Suzuki, H Kasai, H Miura, S Okada, H Oikawa, T Nihira, H Fukuro, H Nakanishi

    KOBUNSHI RONBUNSHU　59　(10)　637-641　2002

    DOI： 10.1295/koron.59.637 　

    ISSN： 0386-2186

  210. Scanning near-field optical microspectroscopy of single perylene microcrystals Peer-reviewed

    JI Niitsuma, T Fujimura, T Itoh, H Kasai, S Okada, H Oikawa, H Nakanishi

    INTERNATIONAL JOURNAL OF MODERN PHYSICS B　15　(28-30)　3901-3903　2001/12

    ISSN： 0217-9792

  211. Photoinduced charge separation and recombination processes in fine particles of oligothiophene-C60 dyad molecules Peer-reviewed

    Mamoru Fujitsuka, Akito Masuhara, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi, Osamu Ito, Takashi Yamashiro, Yoshio Aso, Tetsuo Otsubo

    Journal of Physical Chemistry B　105　(41)　9930-9934　2001/10/18

    DOI： 10.1021/jp0115796 　

    ISSN： 1089-5647

  212. Nano-wire crystals of π-conjugated organic materials Peer-reviewed

    T. Onodera, T. Oshikiri, H. Katagi, H. Kasai, S. Okada, H. Oikawa, M. Terauchi, M. Tanaka, H. Nakanishi

    Journal of Crystal Growth　229　(1)　586-590　2001/07/02

    Publisher: Elsevier

    DOI： 10.1016/S0022-0248(01)01233-7 　

    ISSN： 0022-0248

  213. Hybridized Microcrystals Composed of Metal Fine Particles and π-Cojugated Organic Materials Peer-reviewed

    Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Masami Terauchi, Michiyoshi Tanaka, Hachiro Nakanishi

    Japanese Journal of Applied Physics　40　(10)　L1129-L1131　2001/04

    Publisher: The Japan Society of Applied Physics

    DOI： 10.1143/JJAP.40.L1129 　

    ISSN： 0021-4922

    More details Close

    We have successfully prepared hybridized microcrystals composed of polydiacetylene microcrystals and silver fine particles by means of the co-reprecipitation method, and investigated their hybridized structure and optical properties. It was revealed experimentally for the first time that the core domain of metal fine particles may interact optoelectronically with the shell layer of polydiacetylene in the hybridized microcrystals to give different electronic states from those of the original compounds.

  214. Fabrication of Organic Microcrystals by Supercrytical Fluid Crystallization Method and Their Optical Properties Peer-reviewed

    Hitoshi Kasai, Susumu Okazaki, Shuji Okada, Hidetoshi Oikawa, Tadafumi Adschiri, Kunio Arai, Hachiro Nakanishi

    Kobunshi Ronbunshu　58　650-660　2001/04

  215. Fabrication of Organic Microcrystals, and Their Optical Properties Peer-reviewed

    Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Anisotropic Organic Materials, Eds. R. Glaser and P. Kaszynski, ACS Symposium Series　798　158-168　2001/04

    DOI： 10.1021/bk-2001-0798.ch011 　

  216. Electric-field-induced orientation of polar organic microcrystals with different crystal sizes dispersed in liquid as a novel optical devices Peer-reviewed

    Satoru Okazoe, Satoshi Fujita, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals　367　11-17　2001

    Publisher: Taylor and Francis Inc.

    DOI： 10.1080/10587250108028618 　

    ISSN： 1058-725X

  217. Electric-field-induced orientation of polar organic microcrystals with different crystal sizes dispersed in liquid as a novel optical devices Peer-reviewed

    S Okazoe, S Fujita, H Kasai, S Okada, H Oikawa, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　367　2799-2805　2001

    DOI： 10.1080/10587250108028618 　

    ISSN： 1542-1406

    eISSN： 1563-5287

  218. Hetero-multilayered thin films made up of polydiacetylene microcrystals and metal fine particles Peer-reviewed

    A Masuhara, H Kasai, T Kato, S Okada, H Oikawa, Y Nozue, SK Tripathy, H Nakanishi

    JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY　38　(12)　1371-1382　2001

    DOI： 10.1081/MA-100108391 　

    ISSN： 1060-1325

  219. Scanning near-field optical microspectroscopy of single perylene microcrystals Peer-reviewed

    J Niitsuma, T Fujimura, T Itoh, H Kasai, S Okada, H Oikawa, H Nakanishi

    PROCEEDINGS OF THE 2000 INTERNATIONAL CONFERENCE ON EXCITONIC PROCESSES IN CONDENSED MATTER　15　333-335　2001

    DOI： 10.1142/9789812811387_0079 　

  220. Fabrication of organic and polymer nanocrystals using supercritical fluid Peer-reviewed

    H Kasai, Y Komai, S Okazaki, S Okada, H Oikawa, T Adschiri, K Arai, H Nakanishi

    KOBUNSHI RONBUNSHU　58　(12)　650-660　2001

    DOI： 10.1295/koron.58.650 　

    ISSN： 0386-2186

  221. Various types of polydiacetylene microcrystals fabricated by reprecipitation technique and some applications Peer-reviewed

    Hidetoshi Oikawa, Toshiyuki Oshikiri, Hitoshi Kasai, Shuji Okada, Sukant K. Tripathy, Hachiro Nakanishi

    Polymers for Advanced Technologies　11　(8-12)　783-790　2000/08

    Publisher: John Wiley & Sons Ltd

    DOI： 10.1002/1099-1581(200008/12)11:8/12<783::AID-PAT28>3.0.CO;2-L 　

    ISSN： 1042-7147

  222. Fabrication of metal-coated organic microcrystals Peer-reviewed

    Hideyuki Katagi, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hiro Matsuda, Hachiro Nakanishi

    Polymers for Advanced Technologies　11　(8-12)　778-782　2000/08

    Publisher: John Wiley &amp; Sons Ltd

    DOI： 10.1002/1099-1581(200008/12)11:8/12<778::AID-PAT55>3.0.CO;2-P 　

    ISSN： 1042-7147

  223. Resonant Nonlinearities In An Organic Material: Irradiance Dependence Peer-reviewed

    R. Rangel-Rojo, H. Mastuda, H. Kasai, H. Nakanishi

    Nonlinear Opt.　(25)　379-384　2000/08

    DOI： 10.1364/JOSAB.17.001376 　

  224. Laser flash photolysis study on photophysical and photochemical properties of C60 fine particles Peer-reviewed

    Mamoru Fujitsuka, Hitoshi Kasai, Akito Masuhara, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi, Osamu Ito, Kiyoshi Yase

    Journal of Photochemistry and Photobiology A: Chemistry　133　(1-2)　45-50　2000/05/08

    Publisher: Elsevier

    DOI： 10.1016/S1010-6030(00)00219-7 　

    ISSN： 1010-6030

  225. Preparation of C60 Microcrystals Using High-Temperature and High-Pressure Liquid Crystallization Method Peer-reviewed

    Hitoshi Kasai, Susumu Okazaki, Takeshi Hanada, Shuji Okada, Hidetoshi Oikawa, Tadafumi Adschiri, Kunio Arai, Kiyoshi Yase, Hachiro Nakanishi

    Chemistry Letters　1392-1393　2000/04

    DOI： 10.1246/cl.2000.1392 　

    ISSN： 0366-7022

  226. Novel Fabrication Process of Organic Microcrystals Using Microwave-Irradiation Peer-reviewed

    Koichi Baba, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Japanese Journal of Applied Physics　39　(12)　L1256-L1258　2000/04

    Publisher: The Japan Society of Applied Physics

    DOI： 10.1143/jjap.39.L1256 　

    ISSN： 0021-4922

    More details Close

    The reprecipitation method is a useful technique for the fabrication of organic microcrystals. We have further developed this method for the preparation of some well-defined and monodispersed organic microcrystals by utilizing microwave irradiation.

  227. Fabrication of Organic Microcrystals by Supercritical Fluid Crystallization Method and Their Optical Properties Peer-reviewed

    Hitoshi Kasai, Susumu Okazaki, Shuji Okada, Hidetoshi Oikawa, Tadafumi Adschiri, Kunio Arai, Hachiro Nakanishi

    Nonlinear Optics　24　(1-2)　83-88　2000/04

    ISSN： 1058-7268

  228. Organic Microcrystals as Novel Nano-Materials Peer-reviewed

    Hidetoshi Oikawa, Hitoshi Kasai, Tsuyoshi Kato, Shuji Okada, Hachiro Nakanishi

    The Third SANKEN International Symposium　57　(57)　195-196　2000/03/14

  229. Electric field-induced orientation of organic microcrystals with large dipole moment in dispersion liquid Peer-reviewed

    Hidetoshi Oikawa, Satoshi Fujita, Hitoshi Kasai, Shuji Okada, Sukant K. Tripathy, Hachiro Nakanishi

    Colloids and Surfaces A: Physicochemical and Engineering Aspects　169　(1-3)　251-258　2000

    Publisher: Elsevier Science Publishers B.V.

    DOI： 10.1016/S0927-7757(00)00467-2 　

    ISSN： 0927-7757

  230. Irradiance dependence of the resonant nonlinearities in an organic material Peer-reviewed

    R. Rangel-Rojo, H. Matsuda, H. Kasai, H. Nakanishi

    Journal of the Optical Society of America B: Optical Physics　17　(8)　1376-1382　2000

    Publisher: Optical Society of America (OSA)

    DOI： 10.1364/JOSAB.17.001376 　

    ISSN： 0740-3224

  231. Ultrafast nonlinear refraction in integrated Fabry-Perot etalon containing polydiacetylene Peer-reviewed

    M Bakarezos, MA Camacho, IJ Blewett, AK Kar, BS Wherrett, H Matsuda, T Fukuda, S Yamada, R Rangel-Rojo, H Katagi, H Kasai, S Okada, H Nakanishi

    ELECTRONICS LETTERS　35　(13)　1078-1079　1999/06

    DOI： 10.1049/el:19990759 　

    ISSN： 0013-5194

  232. Electric-Field-Induced Orientation of Organic Microcrystals with Large Dipole Moment Peer-reviewed

    Satoshi Fujita, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Takashi Fukuda, Hiro Matsuda, Sukant, K. Tripathy, Hachiro Nakanishi

    Japanese Journal of Applied Physics　38　(6)　L659-L661　1999/04

    Publisher: The Japan Society of Applied Physics

    DOI： 10.1143/jjap.38.L659 　

    ISSN： 0021-4922

    More details Close

    The microcrystals of molecules with large dipole moment in a non-centrosymmetric crystal structure should possess a huge dipole moment. Therefore, such polar microcrystals dispersed in nonpolar liquid may easily respond to a weak electric field and orient to it. On the basis of this idea, dimethylaminostilbazolium tosylate (DAST) microcrystals dispersed in decahydronaphthalene have been prepared, for which a rather large dipole moment and non-centrosymmetric crystal structures was confirmed. Absorption change of DAST microcrystals was observed even under a extremly weak DC electric field of 100 V&middot;cm-1 and the magnitude of absorption change rate at absorption maximum varied almost linearly up to 300 V&middot;cm-1. This phenomenon may be applied to display devices.

  233. Preparation of Organic Microcrystals Using Supercritical Fluid Crystallization Method Peer-reviewed

    Yuko Komai, Hitoshi Kasai, Hideyuki Hirakoso, Yukiya Hakuta, Hideyuki Katagi, Shuji Okada, Hidetoshi Oikawa, Tadafumi Adschiri, Hiroshi Inomata, Kunio Arai, Hachiro Nakanishi

    Japanese Journal of Applied Physics　38　(1)　L81-L83　1999/04

    Publisher: The Japan Society of Applied Physics

    DOI： 10.1143/JJAP.38.L81 　

    ISSN： 0021-4922

    More details Close

    We propose that the supercritical fluid crystallization (SCFC) method is one of the most promising techniques for preparing organic microcrystals. In the case of titanylphthalocyanine (TiOPc) and diacetylenes, the size and forms of the resulting microcrystals could be controlled by changing SCFC conditions. In particular, the SCFC method for the microcrystallizaton of phthalocyanines is expected to be useful, replacing the previous acid-pasting method.

  234. Ultrafast Optical Switching in Polydiacetylene Fabry-Perot Devices Peer-reviewed

    Hiro Matsuda, Takashi Fukuda, Shinji Yamada, Raul Rangel-Rojo, Hideyuki Katagi, Hitoshi Kasai, Shuji Okada, Hachiro Nakanishi, Efthimios Bakarezos, Miguel A. Camacho-Lopez, Ajoy K. Kar, Brian S. Wherrett

    Nonlinear Optics　22　311-314　1999/04

  235. Electrostatic Self-Assembly of Polydiacetylene Nanocrystals: Nonlinear Optical Properties and Chain Orientation Peer-reviewed

    Jin-An He, Ke Yang, Jayant Kumar, Sukant, K. Tripathy, Lynne A. Samuelson, Toshiyuki Oshikiri, Hideyuki Katagi, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    The Journal of Physical Chemistry B　103　(50)　11050-11056　1999/04

    DOI： 10.1021/jp992633+ 　

  236. Refractive third-order nonlinearity in vanadium-oxide phthalocyanine micro-crystals Peer-reviewed

    Raúl Rangel-Rojo, Shinji Yamada, Hiro Matsuda, Hitoshi Kasai, Yuko Komai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers　38　(1)　69-73　1999

    Publisher: Japan Society of Applied Physics

    DOI： 10.1143/JJAP.38.69 　

    ISSN： 0021-4922

  237. Preparation of organic-inorganic layered perovskite microcrystals Peer-reviewed

    H Kosuge, H Kasai, S Okada, H Oikawa, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　327　115-118　1999

    DOI： 10.1080/10587259908026793 　

    ISSN： 1058-725X

  238. Fabrication of polydiacetylene fibrous microcrystals by the reprecipitation method Peer-reviewed

    T Oshikiri, H Kasai, H Katagi, S Okada, H Oikawa, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　337　25-30　1999

    DOI： 10.1080/10587259908023370 　

    ISSN： 1058-725X

  239. Improved third-order nonlinear optical properties of polydiacetylene derivatives Peer-reviewed

    S Okada, H Nakanishi, H Matsuzawa, H Katagi, T Oshikiri, H Kasai, A Sarkar, H Oikawa, R Rangel-Rojo, T Fukuda, H Matsuda

    ORGANIC NONLINEAR OPTICAL MATERIALS　3796　(3796)　76-87　1999

    ISSN： 0277-786X

  240. Spectrally resolved third-order nonlinearities in polydiacetylene microcrystals: influence of particle size Peer-reviewed

    R Rangel-Rojo, S Yamada, H Matsuda, H Kasai, H Nakanishi, AK Kar, BS Wherrett

    JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS　15　(12)　2937-2945　1998/12

    ISSN： 0740-3224

    eISSN： 1520-8540

  241. Self assembly of organic microcrystals 1: Electrostatic attachment of polydiacetylene microcrystals on a polyelectrolyte surface Peer-reviewed

    SK Tripathy, H Katagi, H Kasai, S Balasubramanian, H Oshikiri, J Kumar, H Oikawa, S Okada, H Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS　37　(3B)　L343-L345　1998/03

    DOI： 10.1143/jjap.37.L343 　

  242. Crystal growth of perylene microcrystals in the reprecipitation method Peer-reviewed

    Hitoshi Kasai, Hidetoshi Oikawa, Shuji Okada, Hachiro Nakanishi

    Bulletin of the Chemical Society of Japan　71　(11)　2597-2601　1998

    Publisher: Chemical Society of Japan

    DOI： 10.1246/bcsj.71.2597 　

    ISSN： 0009-2673

  243. Size and Form Control of Titanylphthalocyanine Microcrystals by Supercritical Fluid Crystallization Method Peer-reviewed

    Yuko Komai, Hitoshi Kasai, Hideyuki Hirakoso, Yukiya Hakuta, Shuji Okada, Hidetoshi Oikawa, Tadafumi Adschiri, Hiroshi Inomata, Kunio Arai, Hachiro Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　322　167-172　1998

    DOI： 10.1080/10587259808030217 　

    ISSN： 1058-725X

  244. Femtosecond transient absorption spectroscopy of nanocrystalline polydiacetylene colloids Peer-reviewed

    Tsuyoshi Asahi, Kazumasa Kibisako, Hiroshi Masuhara, Hitoshi Kasai, Hideyuki Katagi, Hidetoshi Oikawa, Hachiro Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　314　(314)　95-100　1998

    DOI： 10.1080/10587259808042462 　

    ISSN： 1058-725X

  245. Temperature and Crystal Size Dependence of Excitonic Absorption for Polydiacetylene Microcrystals Peer-reviewed

    Hideyuki Katagi, Hidetoshi Oikawa, Shuji Okada, Hitoshi Kasai, Akira Watanabe, Osamu Ito, Yasuo Nozue, Hachiro Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　314　(314)　285-290　1998

    DOI： 10.1080/10587259808042489 　

    ISSN： 1058-725X

  246. Degenerate four-wave mixing using an optical parametric oscillator as an incoherent light source Peer-reviewed

    T Yanagawa, Y Kurokawa, H Kasai, H Nakanishi

    OPTICS COMMUNICATIONS　137　(1-3)　103-106　1997/04

    DOI： 10.1016/S0030-4018(96)00774-2 　

    ISSN： 0030-4018

    eISSN： 1873-0310

  247. Optical properties of perylene microcrystals Peer-reviewed

    H Kasai, Y Yoshikawa, T Seko, S Okada, H Oikawa, H Mastuda, A Watanabe, O Ito, H Toyotama, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　294　173-176　1997

    DOI： 10.1080/10587259708032275 　

    ISSN： 1058-725X

  248. Polydiacetylene microcrystals for third-order nonlinear optics Peer-reviewed

    H Nakanishi, H Kasai

    PHOTONIC AND OPTOELECTRONIC POLYMERS　672　183-198　1997

    ISSN： 0097-6156

  249. Electron spectroscopic imaging of organic fine crystals Peer-reviewed

    K Yase, T Hanada, H Kasai, T Sato, S Okada, H Oikawa, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　294　(294)　71-74　1997

    DOI： 10.1080/10587259708032251 　

    ISSN： 1058-725X

  250. Crystal size dependence of emission from perylene microcrystals Peer-reviewed

    H Kasai, H Kamatani, Y Yoshikawa, S Okada, H Oikawa, A Watanabe, O Itoh, H Nakanishi

    CHEMISTRY LETTERS　(11)　1181-1182　1997

    DOI： 10.1246/cl.1997.1181 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  251. Laser flash photolysis study on photochemical and photophysical properties of C-60 fine particle Peer-reviewed

    M Fujitsuka, H Kasai, A Masuhara, S Okada, H Oikawa, H Nakanishi, A Watanabe, O Ito

    CHEMISTRY LETTERS　(12)　1211-1212　1997

    DOI： 10.1016/S1010-6030(00)00219-7 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  252. Nonlinear refractive indices of polydiacetylene microcrystals Peer-reviewed

    H Matsuda, S Yamada, E VanKeuren, H Katagi, H Kasai, S Okada, H Oikawa, H Nakanishi, EC Smith, AK Kar, BS Wherrett

    PHOTOSENSITIVE OPTICAL MATERIALS AND DEVICES　2998　(2998)　241-248　1997

    DOI： 10.1117/12.264187 　

  253. Size control of polydiacetylene microcrystals Peer-reviewed

    H Katagi, H Kasai, S Okada, H Oikawa, K Komatsu, H Matsuda, ZF Liu, H Nakanishi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS　35　(10B)　L1364-L1366　1996/10

    DOI： 10.1143/JJAP.35.L1364 　

    ISSN： 0021-4922

  254. Organic microcrystals as optical kerr shutter materials

    Hitoshi Kasai, Rieko Iida, Hirohisa Kanbara, Shuji Okada, Hiro Matsuda, Hidetoshi Oikawa, Toshikuni Kaino, Hachiro Nakanishi

    Molecular Crystals and Liquid Crystals Science and Technology Section B: Nonlinear Optics　15　(1-4)　263-266　1996

    Publisher: Gordon &amp; Breach Science Publ Inc

    ISSN： 1058-7268

  255. Size-dependent color and luminescences of organic microcrystals Peer-reviewed

    Hitoshi Kasai, Hirokazu Kamatani, Shuji Okada, Hidetoshi Oikawa, Hiro Matsuda, Hachiro Nakanishi

    Japanese Journal of Applied Physics, Part 2: Letters　35　(2 B)　L221-L223　1996

    Publisher: JJAP

    DOI： 10.1143/JJAP.35.L221 　

    ISSN： 0021-4922

  256. Nonlinear optical properties of J-aggregated merocyanine dye microcrystals in polymer matrices

    H. Matsuda, E. Van Keuren, A. Masaki, K. Yase, A. Mito, C. Takahashi, H. Kasai, H. Kamatani, S. Okada, H. Nakanishi

    Molecular Crystals and Liquid Crystals Science and Technology Section B: Nonlinear Optics　10　(1-4)　123-128　1995

    Publisher: Gordon &amp; Breach Science Publ Inc

    ISSN： 1058-7268

  257. Optical Kerr Shutter Response of Organic Microcrystals Peer-reviewed

    Hitoshi Kasai, Hirohisa Kanbara, Rieko Iida, Shuji Okada, Hiro Matsuda, Hidetoshi Oikawa, Hachiro Nakanishi

    Japanese Journal of Applied Physics　34　(9)　L1208-L1210　1995

    DOI： 10.1143/JJAP.34.L1208 　

    ISSN： 1347-4065 0021-4922

  258. Fabrication and spectroscopic characterization of the nanocrystals of poly[5,7‐dodecadiyn‐1,12‐diol bis(n‐butoxycarbonylmethyl urethane)] Peer-reviewed

    Hari Singh Nalwa, Hitoshi Kasai, Shuji Okada, Hiro Matsuda, Hidetoshi Oikawa, Nobutsugu Minami, Atsushi Kakuta, Akio Mukoh, Katsumichi Ono, Hachiro Nakanishi

    Polymers for Advanced Technologies　6　(2)　69-75　1995

    DOI： 10.1002/pat.1995.220060203 　

    ISSN： 1099-1581 1042-7147

  259. PREPARATION OF J-AGGREGATED MICROCRYSTALS OF PSEUDOISOCYANINE Peer-reviewed

    H KAMATANI, H KASAI, S OKADA, H MATSUDA, H OIKAWA, N MINAMI, A KAKUTA, K ONO, A MUKOH, H NAKANISHI

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　252　(252)　233-241　1994

    DOI： 10.1080/10587259408038229 　

    ISSN： 1058-725X

  260. FABRICATION OF ORGANIC NANOCRYSTALS FOR ELECTRONICS AND PHOTONICS Peer-reviewed

    HS NALWA, H KASAI, S OKADA, H OIKAWA, H MATSUDA, A KAKUTA, A MUKOH, H NAKANISHI

    ADVANCED MATERIALS　5　(10)　758-760　1993/10

    DOI： 10.1002/adma.19930051018 　

    ISSN： 0935-9648

  261. Microcrystals of Functional Chromophores Peer-reviewed

    H. Oikawa, H. Kasai, H. Kamatani, H. S. Nalwa, S. Okada, H. Matsuda, N. Minami, A. Kakuta, K. Ono, A. Mukoh, H. Nakanishi

    Chem. Func. Dyes　(2)　755-758　1993

  262. A novel preparation method of organic microcrystals Peer-reviewed

    Hitoshi Kasai, Hari Singh Nalwa, Hidetoshi Oikawa, Shuji Okada, Hiro Matsuda, Nobutsugu Minami, Atsushi Kakuta, Katsumichi Ono, Akio Mukoh, Hachiro Nakanishi

    Japanese Journal of Applied Physics　31　(8)　L1132-L1134　1992

    DOI： 10.1143/JJAP.31.L1132 　

    ISSN： 1347-4065 0021-4922

Show all ︎Show first 5

Misc. 73

  1. Rechargeable Organic Molecule-Air Battery Peer-reviewed

    Showa Kitajima, Hitoshi Kasai, Kouki Oka

    ECS Meeting Abstracts　MA2024-02　(67)　4464-4464　2024/11/22

    Publisher: The Electrochemical Society

    DOI： 10.1149/ma2024-02674464mtgabs 　

    eISSN： 2151-2043

    More details Close

    [Introduction] The development of environmentally friendly batteries, such as rechargeable aqueous metal-air batteries, has been required for sustainable energy supply. Aqueous zinc-air batteries, composed of zinc as the anode, O2 in the air as the cathode, and a very base aqueous solution (e.g., 6 M KOH aqueous solution) as the electrolyte, are one of the representative environmentally friendly batteries, because of their high energy density (1353 W h kg−1 excluding oxygen) compared to conventional lithium-ion batteries (limited to be &lt;350 W h kg−1 based on the intercalation chemistry).[1] However, these batteries usually have extremely low cyclability because of dendrite formation on the anode and carbonate salt clogging (i.e., the reaction between CO2 in the air and the base) in the electrolyte during charging and discharging. To improve their cyclability, we previously reported a rechargeable organic polymer-air battery using a redox polymer with an anthraquinone derivative (which has a one-step two-electron redox capability in an acidic aqueous solution).[2] This rechargeable organic polymer-air battery exhibits a very high Coulombic efficiency of 99% because of the distorted structure of the anthraquinone derivative. However, organic redox polymers with linear polymer structures are not sufficiently robust for long-term use as an anode-active material in aqueous air batteries. On the other hand, Prof. Yu et al. have recently fabricated a rechargeable organic polymer-air battery using a networked polymer based on anthraquinone as an anode-active material and demonstrated very high cyclability of presumably 99% capacity retention even after 60,000 cycles.[3] This is presumably because the networked polymer forms a robust three-dimensional network that prevents it from decomposing or dissociating from the electrode. However, the Coulombic efficiency was lower than that of organic polymer-air batteries with organic linear polymers, and was only 95%. To achieve both the sufficiently high cyclability and high Coulombic efficiency as an aqueous air battery, the anode-active material must possess high hydrophilicity, exhibit high diffusivity of compensating ions in the material, and have a robust structure that is not decomposed or dissociated from the electrode during charging and discharging. In this work, as the anode-active material, we focused on the anthraquinone molecule itself, which has a reversible redox capacity at the very negative potential close to the potential window in aqueous electrolytes and whose redox properties can be modulated by facile organic synthesis. To improve anthraquinone’s hydrophilicity and inhibit its aggregation, we synthesized 2-propoxyethyl anthraquinone-2-carboxylate. 2-propoxyethyl anthraquinone-2-carboxylate had a reversible redox potential in an acidic aqueous solution, and we established a novel rechargeable organic molecule-air battery using2-propoxyethyl anthraquinone-2-carboxylate as the anode-active material and an acidic aqueous solution as the electrolyte. [Results &amp; Discussions] The battery was chargeable and dischargeable, with the very high Coulombic efficiency of &gt;99% at 15 C. The discharge capacity was almost full capacity, indicating that almost all the molecules contributed to charging and discharging. The discharge capacity remained &gt;99% even after 100 cycles, indicating that the battery had a very high cyclability. Even at 60 C, the discharge capacity of the battery was almost the same as that at 15 C, indicating a high-rate capability. Moreover, the results confirm that this novel rechargeable organic molecule-air battery exhibits the highest cyclability and Coulombic efficiency in rechargeable organic-based aqueous air batteries. Using 2-propoxyethyl anthraquinone-2-carboxylate as an anode-active material in aqueous air batteries will potentially achieve almost the same energy density and increase power density by several times or more, compared to the polymer-air batteries demonstrated. Therefore, the energy density of the aqueous air battery using 2-propoxyethyl anthraquinone-2-carboxylatewill be almost the same as that of metal-air batteries (e.g., zinc-air batteries), and its power density is expected to be higher than that of lithium-ion batteries. We want to discuss this in more detail at the poster session. [Reference] [1] J. Zhang et al., Chem. Sci. 2019, 10, 8924-8929. [2] K. Oka et al., Macromolecules 2021, 54, 4854-4859. [3] L. Zhong et al., Angew. Chem. Int. Ed. 2021, 60, 10164-10171. Figure 1 <p></p>

  2. Redox-Active Metal-Organic Framework As an Anode-Active Material for Rechargeable Air Batteries Peer-reviewed

    Ryota Akai, Hitoshi Kasai, Kouki Oka

    ECS Meeting Abstracts　MA2024-02　(67)　4399-4399　2024/11/22

    Publisher: The Electrochemical Society

    DOI： 10.1149/ma2024-02674399mtgabs 　

    eISSN： 2151-2043

    More details Close

    [Introduction] Rechargeable batteries for the storage of electrical energy are required for the introduction of renewable energy and compact electronic devices for the sustainable society.[1] Although lithium-ion batteries currently dominate the market, rechargeable metal–air batteries with very high energy densities have been attracting attention due to increasing power consumption and demand for low environmental burden. They are composed of oxygen from air as the cathode-active material, metal as the anode-active material and a strong alkaline solution as the electrolyte. They have the advantage of high energy density and low environmental burden due to the use of oxygen as the cathode-active material. While primary Zn–air batteries are commercialized, rechargeable metal–air batteries are under investigation due to their low cycle performance caused by dendrites and metal oxides formed on the metal anode, which leads to disposal of anode-active materials. In addition, strong basic electrolytes are used due to their high ionic conductivity, and the carbonate clogging by carbon dioxide in the air is also a problem. Therefore, rechargeable air batteries, which consist of acid or neutral electrolyte and anode-active materials which is recyclable and do not form dendrites or metal oxides, are required. Organic redox molecules, which are reversibly redox-active organic compounds, are composed of earth-abundant and relatively available building blocks (C, H, N, O, and S), and their functions can be tuned by molecular design, which has attracted attention as new electrode-active materials. We have previously reported that rechargeable polymer–air batteries using an organic redox polymer with organic redox molecules in the side chain of polymer as the anode-active material and acidic aqueous solution as the electrolyte charged and discharged without the formation of dendrites or carbonates.[2] However, organic materials suffer from low durability, and organic redox materials with structural stability in the electrolyte have been required. In the current work, we focused on UiO-66, a metal-organic framework with structural stability in acid and base electrolyte, and synthesized UiO-66-(OH2) with 1,4-dihydroxybenzene, an organic redox molecule as a linker, which undergoes a reversible redox reaction even in acid electrolytes. An anode-active material composed of UiO-66-(OH2) did not form dendrites or metal oxides in H2SO4 aqueous electrolyte (pH 1) and exhibited charge storage with high cycle stability. A rechargeable acidic MOF–air battery was demonstrated for the first time. After use, UiO-66-(OH2) electrode was facilely decomposed and separated to the original raw chemicals by NH4HCO3 aqueous solution. [Results and Discussion] We synthesized UiO-66-(OH2) from zirconium(IV) chloride and 2,5-dihydroxyterephthalic acid by microwave irradiation. UiO-66-(OH2) was coated on a glassy carbon plate in the presence of single-walled carbon nanotube as the conductive additive. The UiO-66-(OH2) electrode exhibited charging-discharging curves of a plateau voltage at 0.2 V, and the ratio of discharging vs. charging capacity (i.e. coulombic efficiency) were nearly 96%. The high capacity of the UiO-66-(OH2) electrode suggested that almost all of the -OH moieties contributed to charge storage. Even after 300 cycles, UiO-66-(OH2) electrode exhibited high cycle performance, which was relatively robust compared to other n-type redox materials for rechargeable aqueous air batteries. These results demonstrated that UiO-66-(OH2) has high cycle stability as an anode-active material for rechargeable acidic MOF-air batteries. A rechargeable acidic MOF-air battery was fabricated with a UiO-66-(OH2), Pt/C, and H2SO4 aqueous electrolyte (pH 1) as the anode material, cathode material, and electrolyte, respectively. The coulombic efficiencies of the battery were nearly 97%, demonstrating the reversible charge storage property of the cell. The high capacity for the anode suggested that almost all of the -OH moieties contributed to charge storage. Even after 100 charging-discharging cycles, the battery kept the high discharging capacity even at a rapid discharging. These results demonstrated the long-life ability of the rechargeable acidic MOF-air battery. UiO-66-(OH2) electrode in the battery was facilely decomposed and separated to the original raw chemicals by NH4HCO3 aqueous solution after charging and discharging. [Conclusions] We synthesized UiO-66-(OH2), which is stable in aqueous electrolyte, and applied it to an anode-active material. The rechargeable acidic MOF-air battery exhibited high cycle performance without the formation of dendrites or carbonates. In addition, we successfully recycled UiO-66-(OH2) electrode after charging and discharging. The current work presented a first step for developing electrode materials for the future energy storage. [References] [1] J. Kim, Y. Kim, J. Yoo, G. Kwon, K. Kang et al., Nat. Rev. Mater. , 8, 54–70, 2023. [2] K. Oka, S. Furukawa, S. Murao, H. Nishide, K. Oyaizu et al., Chem. Commun. , 56, 4055–4058, 2020. Figure 1 <p></p>

  3. Structures and physical properties of 2D Cu(II) coordination polymers with pyrazole-4-carboxylate ligands

    堤咲良, 出倉駿, 出倉駿, 佐藤鉄, 佐藤鉄, 金城克樹, 佐藤卓, 北嶋奨羽, 岡弘樹, 岡弘樹, 笠井均, 笠井均, 芥川智行, 芥川智行

    分子科学討論会講演プログラム&要旨(Web)　18th　2024

  4. Nano-prodrug: The dynamics of novel anticancer drug delivery system Peer-reviewed

    52　(13)　769-773　2020/11/20

  5. Nano-Prodrugs for Anti-cancer Drug Delivery Peer-reviewed

    The Bulletin of the Society of Nano Science and Technology　19　(1)　15-20　2020/09/30

  6. Facile preparation of Au/Silk nanoparticles as a multifunctional drug delivery system

    Anh Dao, Hitoshi Kasai

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　258　2019/08

    ISSN： 0065-7727

  7. 緑内障治療薬ブリンゾラミド誘導体のナノ粒子作製と薬効評価

    小関良卓, 笠井均

    化学工業　69　(4)　304-308　2018/04

  8. コレステロール基を導入した新規SN-38ナノ・プロドラックによる乳癌への治療効果

    多田 寛, 小関 良卓, 宮下 穣, 鈴木 昭彦, 渡部 剛, 原田 成美, 佐藤 章子, 石田 孝宣, 笠井 均, 大内 憲明

    日本乳癌学会総会プログラム抄録集　25回　556-556　2017/07

    Publisher: (一社)日本乳癌学会

  9. 新規ナノ薬剤 ナノ・プロドラッグ

    小関 良卓, 笠井 均

    化学　(72)　68-69　2017/04

    More details Close

    1510

  10. 熱活性化遅延蛍光錯体ナノ結晶の作製と光学特性評価

    鈴木龍樹, 小野寺恒信, 笠井均, 及川英俊

    色材協会誌　89　(5)　149-153　2016/08

    Publisher: Japan Society of Colour Material

    DOI： 10.4011/shikizai.89.149 　

    ISSN： 0010-180X

    More details Close

    1470

  11. 結晶格子歪みで特徴付ける有機・高分子ナノ結晶のサイズ効果

    小野寺 恒信, 笠井 均, 及川 英俊

    M&BE分科会会誌　25　(2)　97-100　2014/06

  12. Fabrication of podophyllotoxin nanoparticles as pure nanodrugs and their anti-cancer properties

    Hitoshi Kasai, Yoshikazu Ikuta, Yoshitaka Koseki, Tsunenobu Onodera, Tatsuya Murakami, Minoru Ueda, Hidetoshi Oikawa

    21st International Congress of Chemical and Process Engineering, CHISA 2014 and 17th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, PRES 2014　2　1132-1133　2014/01/01

  13. 抗癌性ナノ純薬の創製

    笠井均

    週刊医学のあゆみ　247　(2)　196-197　2013/10

  14. ナノ純薬としての二量化SN-38ナノ粒子の創製とその抗癌特性

    笠井均, 幾田良和, 小関良卓, 村上達也

    月刊BIOINDUSTRY　30　(6)　27-32　2013/06

    Publisher: シーエムシー出版

    ISSN： 0910-6545

  15. Preparation and Luminescence Properties of Organic Phosphorescent Nanoparticles

    Fuji Film research & development　(58)　80-84　2013

    Publisher: 富士写真フイルムR&D総括本部知的情報統合部

    ISSN： 0915-1478

  16. 有機ナノ結晶・今・未来

    及川英俊, 笠井 均, 小野寺恒信, 増原陽人, 岡田修司, 中西八郎

    マテリアルインテグレーション　24　230-235　2011/06

  17. 有機ナノ結晶のハイブリッド化とその光材料への応用

    小野寺恒信, 笠井 均, 中西八郎, 及川英俊

    化学工業　62　(4)　254-261　2011/04

    Publisher: 化学工業社

    ISSN： 0451-2014

  18. コア-シェル型有機－金属ヘテロナノ界面の設計・創成

    及川英俊, 小野寺恒信, 増原陽人, 笠井均, 中西八郎

    プラズモンナノ材料の最新技術　95-104　2009/06

    Publisher: シーエムシー出版

  19. Fabrication and Characterization of Shape-Controlled C_<60> Fine Crystals

    MASUHARA Akito, TAN Zhenquan, KASAI Hitoshi, NAKANISHI Hachiro, OIKAWA Hidetoshi

    IEICE technical report　108　(483)　11-16　2009/03/06

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    We would like to report the first time fabrication method of C_<60> fine crystals having various shapes by the SPRP (solvent-participated reprecipitation process) which was the improved technique of ordinary reprecipitation method and a cyclic transformation in shapes and phases of solvent-participated C_<60> fine crystals by exchanging the dispersion medium under supersonic irradiation: as-grown rod→disc→belt→rod, again.

  20. Fabrication of pigment nanocrystals and their application

    60　(3)　182-186　2009/03

    Publisher: 化学工業社

    ISSN： 0451-2014

  21. 再沈法により齎される顔料ナノ結晶の実用化

    笠井均, 馬場耕一, 中西八郎, 宮下陽介

    色材協会誌　82　(9)　411-416　2009

    DOI： 10.4011/shikizai.82.411 　

    ISSN： 0010-180X 1883-2199

  22. フラーレンナノ／マイクロ結晶の創成

    増原陽人, 譚 振権, 笠井 均, 中西八郎, 及川英俊

    炭素 TANSO　238　(238)　109-114　2009

    Publisher: THE CARBON SOCIETY OF JAPAN

    DOI： 10.7209/tanso.2009.109 　

    ISSN： 0371-5345

    More details Close

    Many reports discuss the unique electronic, optical and magnetic properties of fullerene molecules. Such properties originate in their special molecular structure, which is spherical and highly symmetric. Not only fullerene molecules, several interesting papers describe bulk fullerene crystals formed by simple crystal growth from solutions, and which contain solvent molecules. However, only a few studies have been made on the synthesis of uniform fullerene fine crystals with a size in nano/micrometer scale. The preparation of fullerene nano/microcrystals with a uniform size and shape would permit the control of their specific electronic energy levels and the totally new properties. Thus, we have attempted this research, using reprecipitation method developed in our laboratory. By changing simply experimental conditions such as the selection of solvents, we have obtained various unexpected and unique shapes of C60 nano/microcrystals and with surprisingly monodispersed size.

  23. Preparation of Organic Nanocrystals Using Microwave Irradiation and Their Application

    BABA Koichi, KASAI Hitoshi, NAKAMISHI Hachiro

    Materials science and technology　45　(3)　94-99　2008/06/20

    Publisher: 日本材料科学会

    ISSN： 1347-4774

  24. ポリイミドナノ粒子の機能化

    石坂孝之, 笠井 均, 及川英俊, 中西八郎

    ケミカルエンジニアリング, 化学工業社　53　(4)　280-384　2008

    Publisher: 化学工業社

    ISSN： 0387-1037

  25. ポリイミドナノ粒子の調整と機能化

    石坂孝之, 笠井 均, 及川英俊, 中西八郎

    ポリイミドの高機能化と応用技術　第3章　292-301　2008

  26. 有機ナノ結晶の作製とその実用化研究開発

    笠井 均

    究極の粉をつくる, 日刊工業新聞社編　212-220　2008

  27. Fabrication of Organic-Inorganic Hybridized Nanocrystals/Nanoparticles

    Akito Masuhara, Tsunenobu ONODERA, Yusuke YAGUCHI, Jun-ichi UJITA, Hitoshi KASAI, Hidetoshi OIKAWA

    高分子　57　(7月)　2008

  28. Shape-Controlled C60 Nano/Micorocrystals by Solvent-Participated Reprecipitation Process (SPRP)

    Akito Masuhara, Zhenquan Tan, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    高分子　57　(3月)　2008

  29. ポリイミドナノ粒子を用いた低誘電率絶縁膜

    石坂孝之, 笠井 均, 及川英俊

    有機薄膜形成とデバイス応用展開　第5章　248-255　2008

  30. マイクロ波を利用した有機ナノ結晶作製法

    増原陽人, 笠井均, 馬場耕一, 中西八郎, 及川英俊

    分離技術　37　(1)　42-47　2007/03

    Publisher: 分離技術会

    ISSN： 1343-7860

  31. 有機色素系ナノ結晶の作製から応用展開まで

    笠井均, 中西八郎, 宮下陽介

    色材　80　(10)　425-429　2007

    Publisher: Japan Society of Colour Material

    DOI： 10.4011/shikizai1937.80.425 　

    ISSN： 0010-180X

  32. 再沈法による有機ナノ結晶の作製と物性評価および応用展開

    笠井均, 及川英俊, 中西八郎

    応用物理　75　(5)　539-545　2006/04

  33. Fabrication of Organic Nanocrystals and Their Application

    KASAI Hitoshi

    Journal of the Japanese Association of Crystal Growth　32　(3)　213-214　2005/08/17

    Publisher: The Japanese Association for Crystal Growth (JACG)

    ISSN： 0385-6275

    More details Close

    We have established the reprecipitation technique and the related methods for preparing a variety of organic nanocrystals in liquid phase. In my presentation, their properties and application will be also described in detail.

  34. ポリイミドナノ粒子を用いた低誘電絶縁膜

    笠井均, 超汨凡, 石坂孝之, 中西八郎

    OHM　6　8-9　2005/04

  35. 有機・高分子ナノ結晶

    及川英俊, 笠井均, 中西八郎

    THE CHEMICAL TIMES　195　3-9　2005/04

  36. 紫外線照射量と温度を感知するナノスケール材料の開発

    石坂孝之, 笠井均, 及川英俊, 中西八郎

    機械の研究　57　(12)　1213-1218　2005/04

  37. π共役系高分子ナノファイバーの作製

    笠井均

    高分子　53　138-138　2004/04

  38. 様々な手法による有機色素ナノ結晶の作製とそれらの光学特性

    笠井均

    色材　77　(3)　128-132　2004/04

    Publisher: Japan Society of Colour Material

    DOI： 10.4011/shikizai1937.77.128 　

    ISSN： 0010-180X

  39. 再沈法によるポリイミドナノ粒子の作製とその光機能化 Peer-reviewed

    石坂孝之, 笠井均

    高分子加工　53　416-421　2004/04

  40. 新しい材料体系を目指した有機・高分子ナノ結晶の創製

    及川英俊, 増原陽人, 大橋諭, 笠井均, 中西八郎

    表面科学　25　170-176　2004/04

  41. ハイブリッド系有機-金属ナノ結晶における光・電子界面相互作用

    及川英俊, 増原陽人, 大橋諭, 笠井均, 岡田修司, 中西八郎

    表面科学　25　(3)　48-54　2004/04

    Publisher: The Surface Science Society of Japan

    DOI： 10.1380/jsssj.25.170 　

    ISSN： 0388-5321

    More details Close

    Hybridized nanocrystals, which were composed of polydiacetylene (PDA) nanocrystal as a shell layer and silver nano-particle as a core part, were successfully fabricated by means of the "co-reprecipitation method" and the subsequent UV-irradiation to convert the shell layer of solid-state polymerizable diacetylene into PDA. The hybridized core-shell type structure was investigated using both SEM and TEM observations. Interestingly, the plasmon absorption peak of silver nanoparticle decreased and apparently disappeared during UV-irradiation for solid-state polymerization, while the excitonic absorption peak from π-conjugation of PDA was remarkably red-shifted at the same time, compared with only PDA nanocrystal having the same crystal size as the hybridized nanocrystal. These facts suggest that silver nanoparticle of core part may interact optoelectronically with the shell layer of PDA in hybridized nanocrystals to provide different electron states from the original materials.

  42. CONTROL OF LUMINESCENCE INTENSITY FROM RARE EARTH ION (Eu3+, Tb3+)-DOPED POLYIMIDE NANOPARTICLES BY UV-IRRADIATION AND THERMAL TREATMENT

    ISHIZAKA T, KASAI H, NAKANISHI H

    Molecular Crystals and Liquid Crystals　424　103-110　2004

    DOI： 10.1080/15421400490505956 　

    ISSN： 1058-725X

  43. Organic and polymer nanocrystals: Their optical properties and function

    H Oikawa, A Masuhara, H Kasai, T Mitsui, T Sekiguchi, H Nakanishi

    NANOPHOTONICS: INTEGRATING PHOTOCHEMISTRY, OPTICS AND NANO/BIO MATERIALS STUDIES　1　205-224　2004

    DOI： 10.1016/S1574-0641(04)80018-4 　

  44. Electric-Field-Induced Orientation of Polar Organic Nanocrystals in a Disperse System

    ONODERA Tsunenobu, KASAI Hitoshi, OIKAWA Hidetoshi, NAKANISHI Hachiro

    Journal of the Japanese Liquid Crystal Society　7　(2)　170-175　2003/04/25

    Publisher: 日本液晶学会事務局

  45. 極性有機ナノ結晶分散系「液・晶」の電場配向制御 Peer-reviewed

    Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    Ekisho　7　50-55　2003/04

  46. ナノ領域における有機/金属複合体の創製と新規光学特性の確認 Peer-reviewed

    Hidetoshi Oikawa, Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hachiro Nakanishi

    Denshizairyo　4　(4)　24-29　2002/04

    Publisher: 工業調査会

    ISSN： 0387-0774

  47. 有機-無機ハイブリッドナノ結晶 Peer-reviewed

    Hidetoshi Oikawa, Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hachiro Nakanishi

    Material Stage　2　71-76　2002/04

  48. 有機・高分子ナノ結晶の作製とそれらの物性評価,材料化 Peer-reviewed

    Hitoshi Kasai, Hachiro Nakanishi

    Chemical Industry　53　(11)　816-821　2002/04

  49. 新しい材料体系を目指した有機・高分子ナノ結晶の創製 Peer-reviewed

    Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Polymer Application　51　537-544　2002/04

  50. 有機ナノ結晶が面白い！！ Peer-reviewed

    Hitoshi Kasai

    Chemistry, Chemical Industry　55　137-140　2002/04

  51. 東北大多元研の中西G 新手法「共沈法」の確立:有機ー金属のハイブリッドナノ結晶化に成功

    中西八郎, 笠井 均, 及川英俊

    日経先端技術　26　5-6　2002/04

  52. Fabrication of Organic Microcrystals,, Their Optical Properties

    Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Anisotropic Organic Materials", Eds. R. Glaser, P. Kaszynski, ACS Symposium Series　798　158-168　2001/04

    Publisher: ACSBooks

  53. Some Applications of Organic Microcrystals

    Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    Anisotropic Organic Materials", Eds. R. Glaser, P. Kaszynski, ACS Symposium Series　798　169-178　2001/04

    Publisher: ACS Books

    DOI： 10.1021/bk-2001-0798.ch012 　

  54. Development of a near-field optical microscope for absorption spectroscopy and its application to polydiacetylenes nanocrystals

    Takasaka S., Fukutake N., Nakanishi H., Kasai H., Kobayashi T.

    Meeting abstracts of the Physical Society of Japan　56　(1)　652-652　2001/03/09

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  55. Fabrication of organic and polymer nanocrystals using supercritical fluid

    H Kasai, Y Komai, S Okazaki, S Okada, H Oikawa, T Adschiri, K Arai, H Nakanishi

    KOBUNSHI RONBUNSHU　58　(12)　650-660　2001

    DOI： 10.1295/koron.58.650 　

    ISSN： 0386-2186

  56. Relaxation Dynamics of Excitons in Polydiacetylene-DCHD Microcrystals II

    Hamanaka Y., Nishiwaki H., Nakamura A., Kasai H., Masuhara A., Katagi H., Oikawa H., Nakanishi H.

    Meeting abstracts of the Physical Society of Japan　55　(1)　629-629　2000/03/10

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  57. Photoconductive Properties of Titanylphthalocyanine Microcrystals Prepared by Supercritical Fluid Crystallization Method

    Hitoshi Kasai, Susumu Okazaki, Yukiya Hakuta, Tadafumi Adschiri, Kunio Arai, Hidetoshi Oikawa, Haciro Nakanishi

    Polymers for Advanced Technologies　266　2000

  58. Polydiacetylene microcrystals and their third-order optical nonlinearity

    H Kasai, S Okada, H Nakanishi

    MULTIPHOTON AND LIGHT DRIVEN MULTIELECTRON PROCESSES IN ORGANICS: NEW PHENOMENA, MATERIALS AND APPLICATIONS　79　345-356　2000

  59. 26pYB-10 ポリジアセチレンDCHD微結晶の励起子緩和ダイナミクス

    浜中 泰, 西脇 英樹, 中村 新男, 押切 寿行, 片木 秀行, 笠井 均, 及川 英俊, 中西 八郎

    日本物理学会講演概要集　54　(2)　671-671　1999/09/03

    Publisher: 一般社団法人日本物理学会

    ISSN： 1342-8349

  60. Fabrication of organic microcrystals: Their optical properties and applications.

    H Oikawa, H Kasai, H Nakanishi

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　218　U19-U20　1999/08

    ISSN： 0065-7727

  61. Preparation of Polydiacetylene Microcrystals for Nonlinear Optical Application

    KATAGI Hideyuki, OSHIKIRI Toshiyuki, MATSUZAWA Hiroshi, KASAI Hitoshi, OKADA Shuji, OIKAWA Hidetoshi, MATSUDA Hiro, NAKANISHI Hachiro

    Technical report of IEICE. OME　99　(137)　7-13　1999/06/24

    Publisher: The Institute of Electronics, Information and Communication Engineers

    ISSN： 0913-5685

    More details Close

    We established "Reprecipitation method" as a technique for fabricatin gorganic microcrystals. and succeeded in preparing microcrystals for various kinds of organic materials with high disspersion stability and good optical transparency. In polydiacetylene (PDA) microcrystals, it was possible to control the crystal size in range from ca.1O nm to several micrometers by changing concentration of injected solution or by adding surfactants. Microcrystal-dispersed thin film with good optical quality and high density was obtained by dipping a polycation-coated glass substrate into negatively changed microcrystal dispersion. This film showed quite high nonlinear refrative index of 5.4cm^2/GW,which indicates the possibility of optial switching using megawatt-order light intensity

  62. 超臨界流体を利用したγ型チタニルフタロシアニン微結晶の作製

    岡崎進, 笠井均, 岡田修司, 及川英俊, 中西八郎, 伯田幸也, 阿尻雅文, 猪股宏, 新井邦夫

    応用物理学関係連合講演会講演予稿集　46th　(3)　1999

  63. Titanylphthalocyanine Microcrystals Prepared in Supercritical Solvent.

    駒井夕子, 笠井均, 岡田修司, 及川英俊, 伯田幸也, 阿尻雅文, 猪股宏, 新井邦夫, 中西八郎

    日本化学会講演予稿集　72nd　(1)　1997

    ISSN： 0285-7626

  64. TEM Observation of Polydiacetylene Fine Crystals.

    八瀬清志, 花田剛, 松田宏雄, 笠井均, 岡田修司, 及川英俊, 中西八郎

    応用物理学関係連合講演会講演予稿集　44th　(3)　1997

  65. HRTEM Observation of Polydiacetylene Microcrystals.

    八瀬清志, 花田剛, 笠井均, 松田宏雄, 岡田修司, 及川英俊, 中西八郎

    日本電子顕微鏡学会学術講演会発表要旨集　53rd　1997

  66. Preparation and characterization of poly-diacetylene microcrystals

    H Katagi, H Kasai, S Okada, H Oikawa, H Matsuda, H Nakanishi

    JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY　A34　(10)　2013-2024　1997

    ISSN： 1060-1325

  67. Preparation of polydiacetylene microcrystals and their properties

    Hitoshi Kasai, Hideyuki Katagi, Rieko Iida, Shuji Okada, Hidetoshi Oikawa, Hiro Matsuda, Hachiro Nakanishi

    Nippon Kagaku Kaishi / Chemical Society of Japan - Chemistry and Industrial Chemistry Journal　(5)　309-317　1997

    Publisher: Chemical Society of Japan

    DOI： 10.1246/nikkashi.1997.309 　

    ISSN： 0369-4577

  68. PolyDCHD Microcrystals and Their Nonlinear Optical Properties.

    片木秀行, 笠井均, 岡田修司, 及川英俊, 小松京嗣, 松田宏雄, 中西八郎

    高分子学会予稿集　45　(3)　491　1996/05

  69. 有機・高分子微結晶の作製と光物性

    中西 八郎, 笠井 均

    高分子加工　45　(1)　15-19　1996/01

    Publisher: 高分子刊行会

    ISSN： 0023-2564

  70. Preparation of Poly(DCHD) Microcrystals and Nonlinear Optical Properties.

    片木秀行, 飯田理恵子, 笠井均, 岡田修司, 及川英俊, 小松京嗣, 松田宏雄, 中西八郎

    高分子学会予稿集　44　(9)　1941-1942　1995/09

  71. 1)有機微結晶の光学特性(情報ディスプレイ研究会)

    笠井 均, 飯田 理恵子, 佐藤 俊夫, 釜谷 拓和, 岡田 修司, 及川 英俊

    テレビジョン学会誌　49　(4)　587-588　1995/04/20

    Publisher: 一般社団法人映像情報メディア学会

    ISSN： 0386-6831

  72. Solid-state polymerization of diacetylene microcrystals

    R Iida, H Kamatani, H Kasai, S Okada, H Oikawa, H Matsuda, A Kakuta, H Nakanishi

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　267　95-100　1995

    DOI： 10.1080/10587259508033979 　

    ISSN： 1058-725X

  73. Optical Properties of Organic Microcrystals

    Kasai Hitoshi, Iida Rieko, Sato Toshio, Kamatani Hirokazu, Okada Shuji, Oikawa Hidetoshi, Matsuda Hiroo, Yase Kiyoshi, Kakuta Atsushi, Nakanishi Hachiro

    IEICE technical report. Electronic information displays　94　(327)　1-6　1994/11/11

    Publisher: The Institute of Electronics, Information and Communication Engineers

    More details Close

    Organic microcrystals of several tens nanometer to 1 μm in size were successfully prepared by reprecipitation method.Microcrystals of diacetylene monomers could be polymerized to give those of π-co njugated polymer by UV or γ-ray irradiation.For merocyanine and pe rylene microcrystals,optical properties such as absorption and emission were found to be vary depending on their crystal size. Nonlinear optical properties of those samples were also evaluated.

Show all ︎Show first 5

Books and Other Publications 35

  1. Drug-Free Polymer Chemotherapy Using Cell-Material Interaction

    Hirotaka Nakatsuji, Hitoshi kasai, Michiya Matsusaki

    Springer Nature Singapore　2024/10

    ISBN: 9789819752874

  2. Creation of Noble Metallic Nanoparticles for Cancer Therapy

    Anh T. N. Dao, Hitoshi Kasai, Hisayuki Nakatani

    Springer Nature Singapore　2024/10

    ISBN: 9789819752874

  3. Nano-Prodrugs Toward Anticancer Drug Delivery

    Yoshitaka Koseki, Hitoshi Kasai

    Springer Nature Singapore　2024/10

    ISBN: 9789819752874

  4. Recent Advances in Anti-Infective Compounds Produced by Endophytic Fungi.

    Sanjay Kumar, Indu Pathania, Takaaki Kamishima, Yoshitaka Koseki, Hitoshi Kasai, Inder Pal Singh

    Springer Nature Singapore　2024/02/29

    ISBN: 9789819956968

  5. 薬物ナノ結晶製剤の眼内動態評価と眼疾患治療への応用性

    小関良卓, F, Taemaitree, 笠井均

    技術情報協会　2023/01/31

    ISBN: 9784861049361

  6. ナノ・プロドラッグのin vivoにおける薬理効果

    小関 良卓, 幾田 良和, 笠井 均

    技術情報協会　2017/04

    More details Close

    898

  7. 最新 マイクロ波エネルギーと応用技術

    馬場耕一, 笠井均

    株式会社 産業技術サービスセンター　2014/11

  8. Fabrication of Polyimide Porous Nanostructures for Low-k Materials

    T. Ishizaka, H. Kasai

    Nanocrystal, ed., by Marc J.M. Abadie, In Tech　2012/12

  9. ポリイミドナノ粒子による次世代low-k膜生成, Vol.4

    2012/07

  10. Organic Nanocrystals for Nanomedicine and Biophotonics

    Koichi Baba, Hitoshi Kasai, Kohji Nishida, Hachiro Nakanishi

    2010/10

  11. Fabrication of Organic Nanocrystals and Novel Nano-Hybrid Materials

    Tsunenobu Onodera, Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    In Nanohybridization of Organic-Inorganic Materials, eds., Atsushi Muramatsu and Tokuji Miyashita, Springer　2009

  12. 「プラズモンナノ材料の最新技術」

    及川英俊, 小野寺恒信, 増原陽人, 笠井 均, 中西八郎

    シーエムシー出版　2009

  13. 有機・高分子ナノ粒子の作製と応用展開，光機能性高分子材料の新たな潮流 ー最新の技術とその展望

    笠井 均, 石坂孝之, 及川英俊, 中西八郎

    シーエムシー出版　2008

  14. ポリイミドナノ粒子を用いた低誘電率絶縁膜, 有機薄膜形成とデバイス応用展開

    石坂孝之, 笠井 均, 及川英俊

    シーエムシー出版　2008

  15. 有機薄膜形成とデバイス応用展開

    石坂孝之, 笠井均, 及川英俊

    シーエムシー出版　2008/01

  16. 先端科学技術要覧

    笠井均, 趙汨凡, 石坂孝之, 中西八郎

    オーム社　2006/04

  17. 最新ポリイミド材料と応用技術

    石坂孝之, 笠井均

    シーエムシー出版　2006/04

  18. ナノパーティクルハンドブック

    笠井均, 及川英俊, 中西八郎

    日刊工業新聞社　2006/04

  19. 進化する有機半導体

    笠井均, 及川英俊, 中西八郎

    エヌ・ティー・エス　2006/03

  20. ナノハイブリッド材料の最新技術

    増原陽人, 笠井均, 岡田修司, 及川英俊, 中西八郎

    シーエムシー出版　2005/04

  21. 有機結晶材料の最新技術

    及川英俊, 笠井均, 中西八郎

    シーエムシー出版　2005/04

  22. ナノコンポジットマテリアル（第III編）ポリマー系ナノコンポジット（第3章）ハイブリッド系への展開

    中西八郎, 及川英俊, 増原陽人, 小野寺恒信, 笠井 均

    フロンティア出版　2005/04

  23. 日本化学会編 実験化学講座 改訂5版 ナノテクノロジーの化学（第3章）

    中西八郎, 及川英俊, 笠井 均

    丸善　2005/04

  24. ポリイミド・芳香族系高分子最近の進歩2005

    石坂孝之, 笠井均, 中西八郎

    明文社　2005/04

  25. 新訂版・表面科学の基礎と応用

    笠井均

    エヌ・ティー・エス　2004/04

  26. 新訂版 ・表面科学の基礎と応用

    笠井均, 中西八郎

    エヌ・ティー・エス　2004/04

  27. 超臨界流体とナノテクノロジー

    笠井均

    シーエムシー出版　2004/04

  28. マイクロ波の新しい工業利用技術

    笠井均

    エヌ・ティー・エス　2003/04

  29. Nanotechnology toward the Organic Photonics

    Koichi Baba, Eiji Sarashina, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Goo Tech Ltd.　2002/04

  30. Nanotechnology toward the Organic Photonics

    Akito Masuhara, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Hachiro Nakanishi

    Goo Tech Ltd.　2002/04

  31. Nanotechnology toward the Organic Photonics

    Masao Suzuki, Hitoshi Kasai, Shuji Okada, Hidetoshi Oikawa, Takayasu Nihira, Hiroyoshi Fukuro, Hachiro Nakanishi

    Goo Tech Ltd.　2002/04

  32. Current Advancement of Photofunctional Polymeric Materials

    Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    CMC Publishing Co.,Ltd.　2002/04

  33. ACS Symposium Series798: Anisotropic Organic Materials

    Hidetoshi Oikawa, Hitoshi Kasai, Hachiro Nakanishi

    American Chemical Society　2001/04

  34. Organic Mesoscopic Chemistry

    Hitoshi Kasai, Hidetoshi Oikawa, Hachiro Nakanishi

    1999/04

  35. Fabrication and Spectroscopic Characterization of Organic Nanocrystals

    H. Kasai, H. S. Nalwa, S. Okada, H. Oikawa, H. Nakanishi

    Handbook of Nanostructured Materials and Nanotechnology　1999/04

Show all Show first 5

Presentations 129

  1. キャリアフリー有機ナノ粒子の細胞内溶解機構

    ソン ジンウ, テェーマイトリィ ファーサイ, 鈴木 龍樹, 小関 良卓, 雲林院 宏, 笠井 均

    第24回 東北大学多元物質科学研究所研究発表会　2024/12/12

  2. Dissolution Mechanism of Organic Nanoparticles into Lipid bilayer

    Jinwoo Sung, Farsai Taemaitree, Ryuju Suzuki, Yoshitaka Koseki, Hiroshi Uji-i, Hitoshi Kasai

    The 4th Tohoku University (TU)- University of Science and Technology Beijing (USTB)- Symposium　2024/10/29

  3. Fabrication of Nitroreductase-triggered Anticancer Prodrug Nanoparticles for Reduction of Side Effects

    Nagaki Sugeno, Riido Kagaya, Yoshitaka Koseki, Hitoshi Kasai

    The 4th Tohoku University (TU)- University of Science and Technology Beijing (USTB)- Symposium　2024/10/29

  4. Sustained Drug Release from Dual-Responsive Hydrogels for Local Chemo-Photothermal Therapy

    劉 智翔, 小関 良卓, 鈴木 龍樹, Anh Thi Ngoc Dao, 笠井 均

    第75回 コロイドおよび界面化学討論会　2024/09/19

  5. 脂質二重膜での有機ナノ粒子の溶解機構

    ソン ジンウ, テェーマイトリィ ファーサイ, 鈴木 龍樹, 小関 良卓, 雲林院 宏, 笠井 均

    第75回 コロイドおよび界面化学討論会　2024/09/19

  6. 細胞内での溶解および過酸化水素との反応によるプロドラッグナノ粒子からの選択的な薬物放出

    柴田 暁貴, 小関 良卓, 谷田 恵太, 北嶋 奨羽, 岡 弘樹, 丸岡 清隆, 鈴木 龍樹, Anh Thi Ngoc Dao, 笠井 均

    第75回 コロイドおよび界面化学討論会　2024/09/19

  7. Dissolution Mechanism of Organic Nanoparticles into Lipid bilayer

    ソン ジンウ, テェーマイトリィ ファーサイ, 鈴木 龍樹, 小関 良卓, 雲林院 宏, 笠井 均

    令和6年度 化学系学協会東北大会　2024/09/14

  8. Fabrication of prodrug nanoparticles capable of releasing drugs by intracellular dissolution and hydrogen peroxide reaction

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Showa Kitajima, Kouki Oka, Kiyotaka Maruoka, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    GP-Chem Chemistry Summer School 2024　2024/07/20

  9. Selective drug release from nano-prodrugs by dissolution and hydrogen peroxide reaction

    柴田 暁貴, 小関 良卓, 谷田 恵太, 丸岡 清隆, 鈴木 龍樹, Anh Thi Ngoc Dao, 笠井 均

    第40回 日本DDS学会学術集会　2024/07/10

  10. Development of Near-Infrared Light-Responsive NanoDrug@Hydrogel for Cancer Locoregional Therapy

    劉 智翔, 小関 良卓, 鈴木 龍樹, Anh Thi Ngoc Dao, 笠井 均

    第40回 日本DDS学会学術集会　2024/07/10

  11. Fabrication of intracellular releasing induced prodrug nanoparticles by hydrogen peroxide reaction

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Showa Kitajima, Kouki Oka, Kiyotaka Maruoka, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    SECOND SYMPOSIUM FOR YOUNG CHEMISTS (SYNC 2024)　2024/06/25

  12. シンチレータ材料として利用する固体発光性亜鉛錯体ナノ粒子の作製

    冨永征宏, 鈴木龍樹, 小関良卓, 藤本裕, 越水正典, 笠井均

    第23回東北大学多元物質科学研究所研究発表会　2023/12/07

  13. 加水分解性を制御したグルタチオン応答性プロドラッグナノ粒子の作製と薬効評価に関する研究

    水谷 明日香, 柴田 暁貴, 谷田 恵太, 鈴木 龍樹, Anh T., N. Dao, 小関 良卓, 笠井 均

    第23回東北大学多元物質科学研究所研究発表会　2023/12/07

  14. Creation of Hybrid Nanomedicine Composed of SN-38 Prodrugs and Au NPs Towards Chemo-photothermal Therapy

    Taiyufei Liu, Anh T.N. Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    VANJ Conference 2023　2023/12/02

  15. Fabrication of an acrolein-responsive nano-prodrugs with azide-modification for anticancer therapy

    Xianyi Chen, Mitsuki Uehara, Kiyotaka Maruoka, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    第３回マテリアル・計測ハイブリッド研究センター若手フォーラム　2023/11/08

  16. 有機ナノ薬剤の細胞内分解機構の究明

    ソンジンウ、Farsai Taemaitree, 鈴木龍樹, 小関良卓, 笠井均

    第３回マテリアル・計測ハイブリッド研究センター若手フォーラム　2023/11/08

  17. リポソームにより被覆したナノ・プロドラッグのがん細胞内／外挙動の解析

    數井武蔵, Farsai Taemaitree, Beatrice Fortuni, 小関良卓, Anh Thi Ngoc Dao, 鈴木龍樹, 雲林院宏, 笠井均

    第45回日本バイオマテリアル学会大会　2023/11/06

  18. Fragrance Hedione® (methyldihydrojasmonate) from D-Glucose

    Sanjay Kumar, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  19. Fabrication of zinc complex nanoparticles for development of high-performance scintillator

    Masahiro Tominaga, Ryuju Suzuki, Yoshitaka Koseki, Yutaka Fujimoto, Masanori Koshimizu, Hitoshi Kasai

    2023/09/10

  20. Fabrication of an acrolein-responsive nano-prodrugs for anticancer therapy

    Xianyi Chen, Mitsuki Uehara, Kiyotaka Maruoka, Yoshitaka Koseki, Ryuju Suzuki, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  21. Fabrication and drug release properties of prodrug nanopaticles with high cancer selectivity

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Kiyotaka Maruoka, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  22. Total synthesis of azulene derivative, a blue pigment in an edible mushroom

    Kiyotaka Maruoka, Ryuju Suzuki, Takaaki Kamishima, Yoshitaka Koseki, Anh Thi Ngoc Dao, Toshihiro Murafuji, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  23. Development of glutathione-responsive prodrug with selective drug release in cancerous sites

    Ikuma Saitoh, Yoshitaka Koseki, Aki Shibata, Ryuju Suzuki, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  24. Preparation of nanoparticles from triphenylboranes bridged by oxo and phenylimino groups and evaluation of their photophysical properties and cell viability

    Ikumi Koyama, Yuichi Kitamoto, Yoshitaka Koseki, Asuka Mizutani, Hitoshi Kasai, Tetsutaro Hattori

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  25. Development of injectable silk hydrogel loaded with anticancer drugs for controlled release

    Mengheng Yang, Anh Thi Ngoc Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/10

  26. Creation of Hybrid Nanomedicine composed of Au and SN-38 Prodrugs Towards Chemo-Photothermal Therapy

    Taiyufei Liu, Anh Thi Ngoc Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/08

  27. Surface Modifacation of Prodrug Nanoparticle with Apolipoprotein to Improve Dispersion Stability and Hydrolytic Resistance

    Wei Cheng, Hirotaka Nakatsuji, Yoshitaka Koseki, Ryujyu Suzuki, Tatsuya Murakami, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/08

  28. Development of SN-38 prodrug nanoparticles with selective activation by intracellular specific enzymes that cleave s-s bonds in cancer cells

    Asuka Mizutani, Aki Shibata, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Yoshitaka Koseki, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/08

  29. Engineering the Surface of Nano-prodrugs by Biotin-modified Liposomes and Evaluation of their Active Targeting Ability

    Musashi Kazui, Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Anh Thi Ngoc Dao, Ryuju Suzuki, Hiroshi Uji-I, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/08

  30. Synthesis of photo-activated SN;prodrugs a;evaluation of their;anticancer activity

    Momoka Kiyohara, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    International Symposium for the 80th Anniversary of the Tohoku Branch of the Chemical Society of Japan　2023/09/08

  31. Novel Drug Delivery System Using Nano-Prodrugs

    Hitoshi KASAI

    20236th International Society of Materials in Regenerative Medicine and annual Biomaterials and Controlled Release Society (2023 ISOMRM&BCRS)　2023/09/01

  32. Drug Delivery System Using Nano-Prodrugs Invited

    Hitoshi KASAI

    2023/09/01

  33. Newly Designed Drug Delivery System Using Nano-Prodrugs

    Hitoshi KASAI

    Department Colloquium in National YANG MING CHIAO TUNG University　2023/08/29

  34. 「Newly Designed Drug Delivery System Using Nano-Prodrugs」 Invited

    笠井均

    国立陽明交通大学 Department Colloquium　2023/08/29

  35. Development of Near-Infrared Light-Responsive NanoProdrug@Hydrogel for Cancer Locoregional Therapy

    Zhixiang Liu, Yoshitaka Koseki, Ryuju Suzuki, Hitoshi Kasai

    2023 Chemistry summer school　2023/08/09

  36. がん選択性の高いプロドラッグナノ粒子の作製

    柴田暁貴, 小関良卓, 谷田恵太, 丸岡清隆, 鈴木龍樹, Anh Thi Ngoc Dao, 笠井均

    第50回東北地区高分子若手研究会夏季ゼミナール　2023/07/14

  37. Development of Nano-prodrug&Hydrogel for Locoregional Therapy

    Zhixiang Liu, Anh Thi Ngoc Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    2023 MRS Spring Meeting & Exhibit　2023/04/27

  38. Development of Injectable Silk Hydrogel for Nanoprodrugs Control Release

    Mengheng Yang, Anh Thi Ngoc Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    2023 MRS Spring Meeting & Exhibit　2023/04/27

  39. Development of near-Infrared light-responsive nano prodrug@hydrogel for locoregional therapy

    Zhixiang Liu, Anh T. N. Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    日本化学会第103春季年会(2023)　2023/03/25

  40. 光照射により活性化されるSN-38プロドラッグの合成と抗がん活性評価

    清原桃花, 小関良卓, 鈴木龍樹, Anh T.N. Dao, 笠井均

    日本化学会第103春季年会(2023)　2023/03/25

  41. がん細胞内のグルタチオンにより選択的に活性化されるSN-38プロドラッグナノ粒子の開発

    水谷 明日香, 柴田 暁貴, 谷田 恵太, 鈴木 龍樹, Anh Dao, 小関 良卓, 笠井 均

    日本化学会第103春季年会(2023)　2023/03/25

  42. ビオチン修飾リポソームにより被覆されたプロドラッグナノ粒子の作製およびその能動的ターゲティング能の評価

    數井武藏, ファー サイテエーマイトリイ, ベアトリスフォルトゥーニ, 小関良卓, ダオアンティンゴック, 鈴木龍樹, 雲林院宏, 笠井均

    日本化学会第103春季年会(2023)　2023/03/25

  43. β-ラクタマーゼにより活性化されるSN-38-セファロスポリン誘導体の合成と抗がん活性評価

    小関良卓, 上原満季, 鈴木 龍樹, Anh, T.N. Dao, 笠井均

    日本化学会第103春季年会(2023)　2023/03/22

  44. アズレン骨格を有する食用青色キノコ由来色素の全合成

    丸岡清隆, 鈴木龍樹, 神島尭明, 小関良卓, 村藤俊宏, 笠井均

    日本化学会第103春季年会(2023)　2023/03/22

  45. がん細胞選択的な薬物放出性を指向したプロドラッグナノ粒子の創製

    柴田暁貴, 小関良卓, 谷田恵太, 鈴木龍樹, Anh Thi Ngoc Dao, 笠井均

    日本化学会第103春季年会(2023)　2023/03/22

  46. シンチレータ材料として利用する発光性亜鉛錯体ナノ粒子の作製

    鈴木龍樹, 冨永征宏, 小関良卓,藤本裕,越水正典,笠井均

    第70回応用物理学会春季学術講演会　2023/03/15

  47. アズレン骨格を有する食用キノコ由来有機色素の全合成

    丸岡 清隆, 鈴木龍樹, 神島 尭明, 小関 良卓, 村藤 俊宏, 笠井 均

    第37回有機合成化学若手研究者の仙台セミナー　2022/12/10

  48. Creation of Hybrid Nanomedicine composed of Au and SN-38 prodrugs towards Chemo-Photothermal Therapy

    Taiyufei Liu, Anh Thi Ngoc Dao, Yoshitaka Koseki, Ryuju Suzuki, Hitoshi Kasai

    VANJ 2022　2022/11/26

  49. Injectable Silk Hydrogel-based Nanodrug Controlled Release for Local Tumor Therapy

    Mengheng Yang, Anh Thi Ngoc Dao, Ryuju Suzuki, Yoshitaka Koseki and Hitoshi Kasai

    VANJ 2022　2022/11/27

  50. Development of Near-Infrared Light-Responsive Nano-Prodrug@Hydrogel for Locoregional Cancer Therapy

    Zhixiang Liu, Anh T. N. Dao, Ryuju Suzuki, Yoshitaka Koseki, and Hitoshi Kasai

    2022/11/18

  51. Development of Injectable Silk Hydrogels for Targeted Delivery of Nanoprodrugs

    Mengheng Yang, Anh T. N. Dao, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    2022/11/18

  52. Development of SN-38 nano-prodrugs toward anticancer drug delivery Invited

    Yoshitaka Koseki, Hitoshi Kasai

    ICONO13 / ICOPE2022　2022/11/08

  53. Investigation of intracellular dynamics using nano-prodrugs obtained by the reprecipitation method

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Hiroshi, Eduard Fron, Susana Rocha, Johan Hofkens, Uji-i, Tomoko Inose, Hitoshi Kasai

    ICONO13 / ICOPE2022　2022/11/10

  54. 疎水性プロドラッグナノ粒子の生体内安定性の向上を目指したアポ リポタンパク質（apo-AI)による修飾

    程偉, 中辻博貴, 小関良卓, AnhDAO, 鈴木龍樹, 村上達也, 笠井均

    令和4年度化学系学協会東北大会　2022/09/17

  55. Development of nano-prodrug@hydrogel for locoregional therapy

    2022/09/17

  56. Fabrication of nano-prodrugs composed of SN-38 dimer that release drugs with high efficiency in cancer cells

    2022/09/17

  57. Liposomal modification of SN-38 Nano-Prodrugs and Evaluation of their Cellular Uptake

    2022/09/18

  58. Synthesis of natural products from glucose via hydrothermal reaction

    2022/09/18

  59. Development of injectable silk hydrogel loaded with nano-prodrugs for controllable drug release

    2022/09/18

  60. Development of Anticancer Prodrugs Selectively Activated by β-lactamase

    2022/09/18

  61. New Strategy in Nano Drug Delivery By The Reprecipitaion Method

    Hitoshi Kasai

    2022 Tohoku Meeting of Chemical Society of Japan　2022/09/18

  62. Effectively drug release from camptothecin nano-prodrugs with sterically hindered esters derived from tertiary hydroxy groups

    2022/09/03

  63. Fabrication of Anti-inflammatory Nano Eye-Drops Composed of Dexamethasone Prodrugs

    Keita Tanita, Mai Iijima, Yoshitaka Koseki, Kota Sato, Toru Nakazawa, Hitoshi Kasai

    2022/09/03

  64. Drug Delivery System Using Nano-Prodrugs as A New Strategy

    Hitoshi Kasai

    KJF-ICOMEP 2022　2022/09/01

  65. 食用青色キノコに含まれるグアイアズレン誘導体の全合成および微粒子化 Invited

    鈴木龍樹, 丸岡清隆, Anh. T, N. Dao, 小関良卓, 笠井均

    超異分野学会 山形フォーラム2022　2022/08/20

  66. Design and Synthesis of Anticancer Prodrugs Selectively Activated by β-Lactamase

    Mitsuki Uehara, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    2022/08/18

  67. リポソームにより表面修飾したSN-38ナノ・プロドラッグの作製および抗がん活性評価に関する研究

    數井武藏, Farsai Teamaitree, 小関良卓, Anh Dao, 鈴木龍樹, 笠井均

    日本化学会第102春季年会(2022)　2022/03/23

  68. がん細胞内でのみ薬物を放出する新規薬剤ナノ粒子の作製と薬効評価

    谷田恵太, 小関良卓, 鈴木龍樹, アンダオ, 笠井均

    日本化学会第102春季年会(2022)　2022/03/23

  69. アポリポタンパク質(apo A-1)を用いたプロドラッグナノ粒子の表面修飾による分散安定性の向上

    程偉, 中辻博貴, 小関良卓, Anh DAO, 鈴木龍樹, 村上達也, 笠井均

    日本化学会第102春季年会(2022)　2022/03/23

  70. Fabrication of injectable silk hydrogel for controlling the release of various anticancer drugs

    Mengheng Yang, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    2022/03/24

  71. Development of nano-prodrugs@hydrogel materials for locoregional therapy

    Zhixiang Liu, Yoshitaka Koseki, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    2022/03/24

  72. 新規骨格抗菌剤の開発に向けたハイグロホロンB12および誘導体の全合成

    神島尭明, 鈴木仁人, 成田紘一, 小関良卓, 野中利之, 中辻博貴, 服部秀雄, 笠井均

    日本化学会第102春季年会(2022)　2022/03/24

  73. 2,5-ビスヒドロキシメチルフランのシクロペンテノン化合物への水中変換

    中辻博貴, 神島尭明, 野中利之, 小関良卓, 笠井均

    日本化学会第102春季年会(2022)　2022/03/25

  74. 3級エステルを有するプロドラッグの合成とそのナノ粒子の抗がん活性評価

    柴田暁貴, 小関良卓, 谷田恵太, 鈴木龍樹, Anh Thi Ngoc Dao, 笠井均

    日本化学会第102春季年会(2022)　2022/03/26

  75. 有機ナノ粒子の細胞内溶解過程を追跡できる高発光性ナノ粒子の開発

    三木 佑太郎, Farsai Taemaitree, 鈴木 龍樹, 小関 良卓, Anh Dao, 橋本 塁人, 若宮 淳志, 笠井 均

    日本化学会第102春季年会(2022)　2022/03/26

  76. 次世代ナノドラッグデリバリーを志向した研究の紹介 Invited

    笠井均

    日本接着学会東北・北海道地区合同セミナー　2022/03/17

  77. 次世代ナノドラッグデリバリーを目指した研究の紹介 Invited

    笠井均

    ExCELLSセミナー　2022/03/04

  78. Low-cytotoxic gold coated silver nanoflowers toward precise intracellular pH sensing Invited

    Tomoko Inose, Qiang Zhang, Kiri Watanabe, Kenji Hirai, Hitoshi Kasai, Hiroshi Uji-i

    2021/12/17

  79. Design and creation of novel nano-drugs based on research on organic nanocrystals Invited

    Hitoshi Kasai

    2021/12/17

  80. Multi-Functionalize Silk Protein-Based Drug-Carriers via Coalescence with Noble Metallic Nanostructures Invited

    2021/12/17

  81. Pharmacological activity based on the bonding position of guaiazulene derivative

    Kiyotaka Maruoka, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Yoshitaka Koseki, Toshihiro Murafuji, Hitoshi Kasai

    2021/12/19

  82. Design strategy for nano-prodrug with selective and effective activation via tertiary hydroxyl substitution

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    2021/12/19

  83. Intracellular investigation of SN-38 prodrug nanoparticles as carrier-free anticancer drug delivery systems

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Hiroshi Uji-i, Tomoko Inose, Hitoshi Kasai

    2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)　2021/12/17

  84. Fabrication of injectable silk hydrogel for controlling the release of various anticancer drugs

    Mengheng Yang, Anh T.N. Dao, Farsai Taemaitree, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    2021/12/05

  85. Nano Drug Delivery Based on New Strategy Invited

    2021/12/03

  86. Development of novel nano-prodrugs via tertiary hydroxyl substituion

    Aki Shibata, Yoshitaka Koseki, Keita Tanita, Ryuju Suzuki, Anh Thi Ngoc Dao, Hitoshi Kasai

    2021/11/30

  87. Introduction of nano drug delivery based on new strategy Invited

    Hitoshi Kasai

    TU-TaipeiTech Online Joint Symposium 2020　2021/11/30

  88. Fabrication of highly fluorescent FRET NPs for the investigation of intracellular behavior

    Yutaro Miki, Farsai Taemaitree, Ryuju Suzuki, Yoshitaka Koseki, Anh T.N. Dao, Ruito Hashimoto, Atsushi Wakamiya, Hitoshi Kasai

    2021/11/17

  89. FRET-Based Investigation of Carrier-Free Drug Nanoparticles Fate Inside Cancer Cells

    Farsai Taemaitree, Kasai Hitoshi

    14th International Symposium on Nanomedicine (ISNM2021)　2021/11/17

  90. Creation of Nano-Prodrugs Composed of Poorly Water-Soluble SN-38 Derivatives

    Kasai Hitoshi

    2021 MRS-T International Conference　2021/11/17

  91. Design and fabrication of anticancer nano-prodrugs for the investigation of their intracellular dynamics

    Farsai Taemaitree, Kasai Hitoshi

    The 4th Australia-Belgium-Japan joint open symposium on excitonics and cellular communication　2021/10/22

  92. Pharmacological activity of guaiazulene derivatives-conjugated PPT nano-prodrugs

    Kiyotaka Maruoka, Yoshitaka Koseki, Anh Thi Ngoc Dao, Ryuju Suzuki, Batbayar Anudari, Nagaki Sugeno, Hirohito Umezawa, Hitoshi Kasai

    2021/08/29

  93. Polymeric Functionalization of Podophyllotoxin Carrier-free Drug Nanoparticles for Enhancing Bioavailability and In Vitro Cellular Imaging

    Farsai Taemaitree, Masamichi Tamada, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    KJF-ICOMEP2021　2021/08/30

  94. β-ラクタマーゼにより選択的に活性化される抗がん剤プロドラッグの合成

    上原 満季, 小関 良卓, 笠井 均

    日本化学会 第101春季年会　2021/03/22

  95. Fabrication of guaiazulene derivatives nano-prodrugs and their structure-activity evaluation

    Kiyotaka Maruoka, Keita Tanita, Ryuju Suzuki, Yoshitakta Koseki, Toshihiro Murafuji, Hitoshi Kasai

    日本化学会 第101春季年会　2021/03/22

  96. フィルムに担持した薬剤ナノ粒⼦の抗腫瘍活性評価

    齋藤 希望, ファーサイ テェーマイトリィ, 鈴木 龍樹, 小関 良卓, 笠井 均

    日本化学会 第101春季年会　2021/03/22

  97. Fabrication of nano-prodrugs composed of hinokitiol-modified podophyllotoxin

    Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Hitoshi Kasai

    日本化学会 第101春季年会　2021/03/22

  98. Investigation of SN-38 Anticancer Nano-prodrugs Intracellular Dynamics

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Eduard Fron, Susana Rocha, Johan Hofkens, Hiroshi Uji-i, Anh Thi Ngoc Dao, Ryuju Suzuki, Tomoko Inose, Hitoshi Kasai

    日本化学会 第101春季年会　2021/03/22

  99. Development of Fabrication Technique for Drug Nanoparticles toward Efficient Cancer Therapy

    Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki. Anh Thi, Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    The 8th Asian Conference on Crystal Growth and Crystal Technology (CGCT-8)　2021/03/03

  100. Intracellular investigation of carrier-free nano-prodrugs toward highly efficient anticancer drug delivery systems

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Eduard Fron, Susana Rocha, Johan Hofkens, Hiroshi Uji-i, Ryuju Suzuki, Anh Dao, Tomoko Inose, Hitoshi Kasai

    Samaggi Academic Conference and Careers Fair 2021　2021/01/21

  101. Intracellular investigation of SN-38 nano-prodrugs toward anticancer drug delivery applications

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Eduard Fron, Susana Rocha, Hiroshi Uji-I, Johan Hofkens, Anh T. N. Dao, Ryuju Suzuki, Tomoko Inose, Hitoshi Kasai

    2020/12/01

  102. Fabrication of Silk Protein to Hybrid Nanocarriers for Cancer Therapy International-presentation Invited

    Anh T. N. Dao, M. Nakamura, F. Taemaitree, H. Kasai

    VANJ Conference 2020　2020/11/28

  103. Novel designed nano-prodrugs composed of poorly water-soluble compounds International-presentation Invited

    Hitoshi Kasai

    VANJ Conference 2020　2020/11/28

  104. 粒子のままでがん細胞内までデリバリーされるナノ薬剤の設計と創製 Invited

    笠井 均

    2020年度合同ウェブ分科会　2020/11/27

  105. Microstructural Analysis of Au/Pt Core/Shell Nanoparticles Synthesized Using Galvanic Replacement

    2020/11/14

  106. ガルバニック置換反応により合成したAu/Pt コア/シェルナノ粒子におけるPtシェル形成機構の考察

    竹内勇太, 寺西亮, 佐藤幸生, Anh T, N. Dao, 笠井均, 金子賢治

    第62回日本顕微鏡学会 九州支部総会・学術講演会　2020/11/14

  107. Fabrication of Different Kinds of Organic Nanocrystals and Their Application ~ Development for Novel Designed Nano-Prodrugs as Main Topics ~ Invited

    Hitoshi Kasai

    2020/10/21

  108. グアイアズレン誘導体ナノプロドラッグの作製と薬効特性評価

    丸岡清隆, 谷田恵太, 鈴木龍樹, 小関良卓, 村藤俊宏, 笠井均

    2020 PHyM シンポジウム　2020/10/19

  109. Intracellular investigation of nanoprodrugs towards anticancer drug delivery application

    Farsai Taemaitree, Beatrice Fortuni, Yoshitaka Koseki, Eduard Fron, Susana Rocha, Johan Hofkens, Hiroshi Uji-i, Tomoko Inose, Hitoshi Kasai

    2020/10/19

  110. METAL ION ENRICHMENT USING ORGANIC NANOCRYSTAL COATED-MICROFLUIDIC

    Grasianto, Mao Fukuyama, Derrick Mott, Yoshitaka Koseki, Hitoshi Kasai, Akihide Hibara

    MicroTAS 2020 Virtual Conference　2020/10/05

  111. Fabrication SN-38 Nano-Prodrugs for Anticancer Drug Delivery

    小関良卓, 笠井均

    2020/09/27

  112. Tracking intracellular dynamics of anticancer nano-prodrugs using Raman imaging

    2020/09/27

  113. Microstructural TEM Observation of Au-Ag-Pt Nanoparticles Synthesized by A Galvanic Replacement Reaction

    Lee HuJun, 渡辺千遥, 竹内勇太, 九大工, 佐藤幸生, 寺西亮, 金子賢治, Anh T, N. Dao, 笠井均

    2020/05/29

  114. Polymeric engineering of prodrug nanoparticles for the investigation of intracellular drug dynamics

    Farsai Taemaitree, Beatrice Fortuni, Tomoko Inose, Yoshitaka Koseki, Hiroshi Uji-I, Hitoshi Kasai

    2020/05/29

  115. Silk Protein Fabricated with Metallic Nanoparticles for a Multifunctional Drug Delivery System

    Anh T. N. Dao, M. Nakamura, F. Taemaitree, H. Kasai

    2020/05/29

  116. フィルムに担持した抗がん剤ナノ粒子の再放出挙動と薬効評価

    齋藤希望, ティーマイトリー, ファーサイ, 鈴木龍樹, 小関良卓, 笠井均

    第69回高分子学会年次大会　2020/05/29

  117. ドラッグデリバリーシステムのための シルクナノ粒子の作製と特性評価

    中村 元郁, ティーマイトリー ファーサイ, Anh T.N. Dao, 笠井 均

    日本化学会 第100春季年会　2020/03/22

  118. Fabrication SN-38 Nano-Prodrugs and Their Anticancer Activity

    Yoshitaka Koseki, Yoshikazu Ikuta, Liman Cong, Mayumi Takano-Kasuya, Hiroshi Tada, Mika Watanabe, Kohsuke Gonda, Takanori Ishida, Noriaki Ohuchi, Keita Tanita, Farsai Taemaitree, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai

    2020/03/23

  119. Fabrication of guaiazulene derivatives nanoparticles and their pharmacological activity

    Kiyotaka Maruoka, Keita Tanita, Ryuju Suzuki, Yoshitaka Koseki, Hitoshi Kasai

    2020/03/24

  120. 効果的な感染症の治療を目指した再沈法による抗菌剤ナノ粒子の作製

    山内啓大朗, 谷田恵太, 小関良卓, 笠井均

    日本化学会 第100春季年会　2020/03/24

  121. SN-38 の DE 環の部分合成

    戸田成美, 小関良卓, 笠井均

    日本化学会 第100春季年会　2020/03/24

  122. 高分子フィルムへの薬剤ナノ粒子の担持と放出挙動

    齋藤希望, ティーマイトリー, ファーサイ, 鈴木龍樹, 小関良卓, 笠井均

    日本化学会 第100春季年会　2020/03/23

  123. Development of nano-prodrugs composed of hinokitiol-modified anticancer drugs

    Keita Tanita, Yoshitaka Koseki, Takaaki Kamishima, Kazue Shimizu, Hirohito Umezawa, Hitoshi Kasai

    2020/03/24

  124. Creation of Novel Designed Nano-Prodrugs and Their Pharmacological Effect International-presentation Invited

    KASAI Hitoshi

    2019 ANNUAL NANOTECHNOLOGY CONFERENCE　2019/09/11

  125. 再沈法による新規ナノ・プロドラッグの創製と薬理活性 Invited

    笠井 均

    第八回 ナノカーボンバイオシンポジウム　2018/09/10

  126. Creation of Nano-Prodrugs Composed of Poorly Water-Soluble Compounds Using by the Reprecipitation Method International-presentation Invited

    KASAI Hitoshi

    2018 International Symposium on Chemical-Environmental-Biomedical Technology　2018/09/07

  127. 次世代ナノ薬剤の創出に向けた挑戦

    笠井 均

    PHyMシンポジウム　2018/06/19

  128. 再沈法を駆使したナノ・プロドラッグの創製 Invited

    笠井 均

    ナノ学会第16回大会　2018/05/11

  129. 再沈法を駆使したナノ薬剤の開発

    笠井 均

    「ナノマテリアルの実用展開」 in ナノマテリアルコロキウム　2018/01/19

Show all Show first 5

Industrial Property Rights 40

  1. 眼疾患治療用ナノ粒子製剤

    青 柳, 重 信, 稲 田, 諭, 渋 谷, 博, 笠 井, 均, 中 澤

    Property Type: Patent

  2. Y型チタニルフタロシアニン結晶の製造方法

    菊地 巧也, 笠井 均, 及川 英俊

    Property Type: Patent

  3. 薬剤多量体微粒子及びその製造方法

    笠井 均, 中西 八郎, 馬場 耕一, 及川 英俊, 村上 達也, 今堀 博, 橋田 充, 王 勇

    Property Type: Patent

  4. 眼内移行性の高い点眼剤および蛍光イメージング剤ならびにそれらの製造方法

    西田 幸二, 馬場 耕一, 笠井 均, 田中 佑治, 久保田 享, 横倉 俊二

    Property Type: Patent

  5. ポリイミド微粒子凝集体の製造方法

    石坂 孝之, 笠井 均, 中西 八郎, 及川 英俊, 水上 富士夫

    特許第5429922号

    Property Type: Patent

  6. 有機化合物結晶の製造方法

    宮下 陽介, 中西 八郎, 及川 英俊, 笠井 均, 馬場 耕一, 菅井 健二

    Property Type: Patent

  7. 固体微粒子及びその製造方法

    中西 八郎, 笠井 均, 及川 英俊, 權 垠相

    Property Type: Patent

  8. 顔料ナノ粒子の製造方法

    宮下 陽介, 中西 八郎, 及川 英俊, 笠井 均, 馬場 耕一, 菅井 健二

    Property Type: Patent

  9. 有機微結晶の配向制御法

    島田 悟, 金子 祐司, 木村 龍実, 松田 宏雄, 横井 裕之, 角舘 洋三, 小野寺 恒信, 笠井 均, 岡田 修司, 及川 英俊, 中西 八郎

    特許第4781803号

    Property Type: Patent

  10. 金属被覆型有機結晶の製造方法

    小野寺 恒信, 及川 英俊, 笠井 均, 中西 八郎, 関口 隆史

    Property Type: Patent

  11. ナノ粒子の濃縮方法

    宮下 陽介, 中西 八郎, 笠井 均, 増原 陽人

    特許第4870383号

    Property Type: Patent

  12. 凝集ナノ粒子の分散方法

    宮下 陽介, 中西 八郎, 笠井 均, 増原 陽人

    特許第4993875号

    Property Type: Patent

  13. 孔質性ポリアミド酸微粒子および孔質性ポリイミド微粒子の製造方法

    中西 八郎, 笠井 均, 石坂 孝之

    特許第4125296号

    Property Type: Patent

  14. 有機顔料微粒子の製造方法

    関根 信博, 浅田 匡彦, 堀米 操, 中西 八郎, 笠井 均

    Property Type: Patent

  15. 疎水性有機系色素微粒子分散液又は疎水性有機系色素微粒子の製造方法、それに用いて好適な噴霧器、噴霧装置、及び粒子制限フード。

    鈴木 敏重, 高橋 由紀子, 笠井 均, 中西 八郎

    特許第4933726号

    Property Type: Patent

  16. 有機結晶の溶解方法

    中西 八郎, 笠井 均

    特許第4300144号

    Property Type: Patent

  17. 金属イオン検出フィルム、その製造方法、及びそれを用いた金属イオン定量方法

    鈴木 敏重, 高橋 由紀子, 笠井 均, 中西 八郎

    特許第4185982号

    Property Type: Patent

  18. 有機微結晶配向分散体、偏光蛍光材料、並びにその製造方法

    金子 祐司, 松田 宏雄, 福田 隆史, 島田 悟, 木村 龍実, 小野寺 恒信, 笠井 均, 岡田 修司, 及川 英俊, 中西 八郎

    特許第3979500号

    Property Type: Patent

  19. 光照射又は熱処理による蛍光特性の変化を利用する書き換え可能な光メモリー材料

    中西 八郎, 笠井 均, 石坂 孝之

    特許第4058397号

    Property Type: Patent

  20. 機能性を有するポリイミド微粒子の製造方法

    中西 八郎, 笠井 均, 石坂 孝之

    特許第4098688号

    Property Type: Patent

  21. 微粒子含有分散液の濃縮法および微粒子回収方法

    横山 千昭, 笠井 均, 更科 英二, 猪股 宏, 中西 八郎

    特許第4275976号

    Property Type: Patent

  22. 孔質性ポリイミド系微粒子の製造方法

    中西 八郎, 笠井 均, 三浦 啓彦, 及川 英俊, 岡田 修司

    特許第4030419号

    Property Type: Patent

  23. ナノ粒子含有水溶液の濃縮乃至ナノ粒子回収方法

    横山 千昭, 更科 英二, 中西 八郎, 笠井 均

    Property Type: Patent

  24. 偏光カラーフィルターとその製造方法

    金子 祐司, 松田 宏雄, 福田 隆史, 小野寺 恒信, 笠井 均, 岡田 修司, 及川 英俊, 中西 八郎

    Property Type: Patent

  25. 顔料ナノ粒子の新規な製造方法

    中西 八郎, 馬場 耕一, 笠井 均, 及川 英俊, 岡田 修司

    特許第4326197号

    Property Type: Patent

  26. 粒径および粒度分布が制御されたポリイミド微粒子の製造方法

    笠井 均, 及川 英俊, 中西 八郎, 岡田 修司, 鈴木 正郎

    特許第4465143号

    Property Type: Patent

  27. 有機・無機複合微結晶の製造方法

    中西 八郎, 及川 英俊, 岡田 修司, 笠井 均

    Property Type: Patent

  28. 有機顔料の製造方法、及び該有機顔料を含有する電子写真感光体、画像形成方法、画像形成装置及びプロセスカートリッジ

    駒井 夕子, 所司 正幸, 中西 八郎, 及川 英俊, 笠井 均

    Property Type: Patent

  29. キナクリドン系顔料微結晶の製造方法

    笠井 均, 中西 八郎, 新井 邦夫

    Property Type: Patent

  30. 表示素子

    中西 八郎, 及川 英俊, 笠井 均, 長谷部 浩史

    Property Type: Patent

  31. 光電子機能用有機微結晶の製造方法

    松田 宏雄, 福田 隆史, 馬場 耕一, 笠井 均, 岡田 修司, 及川 英俊, 中西 八郎

    特許第3584266号

    Property Type: Patent

  32. 電子写真感光体

    岡崎 進, 笠井 均, 岡田 修司, 及川 英俊, 中西 八郎, 伯田 幸也, 阿尻 雅文, 猪股 宏, 新井 邦夫

    特許第3883338号

    Property Type: Patent

  33. 双極子微粒子を分散させた材料を用いた表示素子

    中西 八郎, 笠井 均, 藤田 賢志, 岡田 修司, 及川 英俊, 林 豊治

    特許第4125415号

    Property Type: Patent

  34. 非線形光学装置

    神原 浩久, 戒能 俊邦, 笠井 均, 飯田 理恵子, 岡田 修司, 及川 英俊, 中西 八郎

    Property Type: Patent

  35. 有機超微粒子の製法

    笠井 均, 及川 英俊, 小野 勝道, 中西 八郎, 岡田 修司, 松田 宏雄, 南 信次, ハリ, シング ナルワ, 角田 敦, 向尾 昭夫

    Property Type: Patent

  36. 非線形光学用有機微結晶の製法

    笠井 均, 及川 英俊, 小野 勝道, 中西 八郎, 岡田 修司, 松田 宏雄, 南 信次, ハリ, シング ナルワ, 角田 敦, 向尾 昭夫

    特許第2723200号

    Property Type: Patent

  37. ニッケルナノ粒子担持体の製造方法及びニッケルナノ粒子担持体

    小関 良卓, 鈴木 龍樹, 笠井 均, 加納 純也

    Property Type: Patent

  38. Production method for cyclopentenone derivative

    Yoshitaka Koseki, Hitoshi Kasai, Takaaki Kamishima

    特許11014865

    Property Type: Patent

    Holder: Tohoku University NUC, Genesis Research Institute Inc

  39. 薬剤多量体微粒子及びその製造方法

    笠井 均, 中西 八郎, 馬場 耕一, 及川 英俊, 村上 達也, 今堀 博, 橋田 充, 王 勇

    特許第5113958号

    Property Type: Patent

  40. 眼内移行性の高い点眼剤および蛍光イメージング剤ならびにそれらの製造方法

    西田 幸二, 馬場 耕一, 笠井 均, 田中 佑治, 久保田 享, 横倉 俊二

    特許第5709523号

    Property Type: Patent

Show all Show first 5

Research Projects 11

  1. がん細胞特有の刺激に応答し薬物を放出する新規抗がん薬ナノ粒子の開発

    笠井 均, 小関 良卓, 雲林院 宏, 根本 知己, 石岡 千加史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(A)

    Institution: 東北大学

    2022/04/01 - 2026/03/31

  2. Knowledge-driven Nanodrug design through understanding of a role of Phase-separated condensate in chemotherapy using Single-Cell endoscopy

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Hokkaido University

    2021/04/05 - 2025/03/31

  3. 分子技術を駆使したSN-38二量体設計と新規抗がん用ナノ薬剤の創出

    笠井 均, KUMAR SANJAY

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2022/04/22 - 2024/03/31

  4. 瘢痕化定量技術と薬剤ナノ粒子化による組織移行性の高い濾過胞瘢痕抑制薬の開発

    津田 聡, 中澤 徹, 笠井 均, 小関 良卓, 佐藤 孝太, 國分 太貴

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

  5. Development of anti-cancer nanodrugs with high drug loading capacity and dispersion stability by surface modification

    Kasai Hitoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

    More details Close

    In the present study, surface modification with albumin was investigated to improve the drug delivery efficiency of nano-prodrugs consisted only of prodrug molecules. The results showed that the surface-modified nano-prodrugs exhibited better cellular uptake than the unmodified ones. In other words, the surface modification with albumin is expected to disperse well in the biological environment and exhibit high pharmacological activity by being taken up by cancer cells after transfer to tumor tissues.

  6. Application of new indole compounds to organ protection in the Cardiovascular surgery

    Adachi Osamu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

    More details Close

    The new indole compound has depression effect for the ischemic reperfusion injury of the brain and kidney.We examined efficacy for the organ protection in the cardiovascular surgery region.Spinal cord injury is a serious complication in the replacement of the thoracoabdominal artery.In the perioperative spinal cord blood hypoperfusion model using the rabbit, the spinal ischemic reperfusion depression effect was not found.We evaluated a donor cardioprotection effect in the heart transplant. We examined a change of the quantity of rat myocardial ATP by the elapsed time from heart extraction. The myocardial ATP content decreased equally with a non-administration group two hours after the heart extraction. In these examination, we were not able to demonstrate spinal cord and myocardial protection effect.

  7. Creation of novel drug nanoparticles based on the conventional reverse molecular design using poor water-soluble compounds and the efficacy evaluation

    KASAI HITOSHI, OIKAWA Hidetoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2013/04/01 - 2017/03/31

    More details Close

    In this project, we introduced a new concept of introducing a poorly water-soluble substituent into anticancer medicinal compounds. Next, we synthesized them and then created the drug nanoparticles by using our own technique of the reprecipitation method. And, it was found that, by covering polymers or proteins on these drug nanoparticles, dispersion stability of the nanodrug could be improved. In vivo experiment, it was revealed that the nanodrugs could be delivered into the inside of cells of the tumor tissue. And this technique could be applied as eye drops including the glaucoma and so on.

  8. Size and Morphology Control of Organic nanocrystals

    KASAI Hitoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2011

    More details Close

    In this study, it was found that the kinetics on generation of the organic nanocrystals in the reprecipitation method follow a classic nucleation theory. And then, supersaturation ratio is a critical factor determining the nanoparticle size in the the method. Using these knowledges, regarding the pigment nanocrystals, fabrication of the fine sized pigments nanocrystals with around 15 nm in size could also be achieved. Tn addition, it was shown that the contrast ratio of color filter of nanocrystals prepared by the reprecipitation method gave several times greate than that of pigment crystals fabricated by the conventional technique.

  9. Fabrication of Light-Harvesting Antenna Nanocrystalline System Composed of Porphyrin Compounds and Their Optical Properties

    KASAI Hitoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2007 - 2008

  10. 高温高圧下における超高濃度溶液からの再沈澱操作による有機ナノ結晶の作製

    笠井 均

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究(B)

    Institution: 東北大学

    2002 - 2004

    More details Close

    本年度の若手研究(B)の成果としては、以下の通りである。 対象有機化合物の高濃度溶液と貧溶媒をY字部で混合させる流通式再沈法のセットアップを構築し、同セットアップによる一連の有機ナノ結晶の作製実験では、混合部であるY字部にて、ナノ結晶が詰まり管内圧力が高くなるなどの問題点を残った。その点を解決するため、設備費で購入したパーソナルポンプを用いて、溶液をよく撹拌した貧溶媒中に直接的に注入するという再沈澱処理により、ナノ結晶化を検討した。使用する化合物は、サイズの微細化が特に求められている顔料系の中でも、高級赤色顔料の約半分を占めるといわれるキナクリドンとした。ポイントの一つは高濃度溶液の調製にあったが、溶媒にアミド系溶剤を用いて、且つマイクロ波の照射を施すことにより、約20mMという溶液の高濃度化に成功した。ポンプの最高性能である毎分100mlという注入速度で、同高濃度溶液を貧溶媒である水中に注入した結果、1分間約1gという高効率ペースで、サイズが約50nmでほぼ揃ったキナクリドンナノ結晶を生産できた。作製したナノ結晶は、粉末x線回折法により結晶型はα型であることが判明した。ここで、開発された技術は、サイズをより微小化すること、結晶型の制御、調製された分散液の濃縮方法が将来的に確立されれば、インク、トナー、OPC材料などへの様々な応用へと繋がる技術であることは間違いなく、さらには、カラーフィルターなど高品質化に向けた作製粒子の薄被膜化への実用化も考えられ、今後の研究に期待される。

  11. 超臨界流体を利用した難溶性π共役有機化合物の微結晶の作製とその光・電子特性の評価

    笠井 均

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 東北大学

    2000 - 2001

    More details Close

    キナクリドンまたはその誘導体は、全赤色顔料の半分近くに使われていると同時に、EL材料などにも有望なことが知られているが、それらは難溶性、難加工性という欠点を有する化合物であるため、精製や材料化が容易ではなかった。特に、サイズ制御されたキナクリドン系微結晶を作製することは、従来困難な状況であった。そこで、溶媒として超臨界流体を使用し、そこから再沈澱するという超臨界再沈法を用いることにより、ナノオーダーレベルで制御されたキナクリドン系微結晶の作成を試みた。 種々の作製条件を検討した結果、粒経500nm以下の領域でサイズ制御が可能であることが分かった。例えば、超臨界流体の温度を上昇させると、溶出濃度が向上するため、サイズが大きくなる傾向がある。その他、超臨界流体の種類、冷却溶媒の種類・温度によっても、生成される微結晶のサイズ・結晶型は制御可能であった。また、結晶型は同型にも拘わらず、サイズが微小化すると光吸収ピーク位置が、従来には観測されない程、高エネルギー側にシフトするという特徴を有することも判明した。これは、他のπ共役有機微結晶にもみられる特有のサイズ効果と同様の挙動である。さらに、200℃から270℃までという超臨界温度に達する前に、薄い黄色呈色の液体が流出することも判明した。これは、キナクリドン合成時の副生成物が流出すること、すなわちキナクリドンが精製されていることを意味している。 以上のように、精製が同時工程で可能であること、更にサイズを制御することにより、従来には無い光吸収ピークを有するキナクリドン微結晶が得られたことは、機能性材料に使用するという点において、非常に意義深い。同時に、得られた微結晶分散水は分散安定性が高く、湿式インキ・顔料としても有望である。本奨励研究の目的は十分に達成できたと考える。

Show all Show first 5