Details of the Researcher

PHOTO

Akihiro Kanaya
Section
Graduate School of Medicine
Job title
Assistant Professor
Degree

  • 博士（医学）（東北大学）

Research History 6

  • 2024/04 - Present
    東北大学大学院医学系研究科　麻酔科学周術期医学分野　助教

  • 2022/12 - 2024/03
    Department of Anesthesiology　University Hospital Intensive Care　Assistant professor

  • 2020/10 - 2022/11
    コロンビア大学麻酔科　客員助教

  • 2019/04 - 2022/11
    Tohoku University　Faculty of Medicine

  • 2019/04 - 2020/10
    国立病院機構仙台医療センター　麻酔科　医師

  • 2018/07 - 2019/03
    東北大学病院　麻酔科　助教

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Research Interests 1

  • 麻酔科学

Research Areas 1

  • Life sciences / General surgery, pediatric surgery /

Awards 4

  1. 近江記念地域医療研究調査奨励賞

    2024/09　公益財団法人 艮陵医学振興会　産科危機的出血に対する危険因子の解明と最適な治療戦略の構築

  2. 奨励賞

    2024/07　日本集中治療医学会第8回東北支部学術集会　脳死両肺移植術後の換気の評価にデジタルX線動画撮影システムを用いた1症例

  3. Academic Evening Best Abstract Award (Second Prize)

    2021/11　Department of Anesthesiology, Columbia University College of Physicians and Surgeons　Chronic Allergic Lung Inflammation Negatively Influences Neurobehavioral Outcomes in Mice

  4. 海外留学助成金リサーチフェローシップ

    2021/03　公益財団法人上原記念生命科学財団　急性呼吸窮迫症候群とゲルソリンタンパク質の関連

Papers 36

  1. Utilization of a Digital Radiographic Imaging System for Assessing Ventilation and Guiding Rehabilitation in a Post-lung Transplant Patient: A Case Report Peer-reviewed

    Akihiro Kanaya, Shoma Tanaka, Hidenobu Takagi, Elvedin Lukovic, Masanori Yamauchi

    Cureus 17(7): e87955.　2025/07/14

    Publisher: Springer Science and Business Media LLC

    DOI： 10.7759/cureus.87955 　

    ISSN： 2168-8184

  2. Effects of chronic allergic lung inflammation on gut microbiota and depression-like behavior in mice Peer-reviewed

    Akihiro Kanaya, Elvedin Luković, Charles Emala, Maya Mikami

    Exploration of Asthma & Allergy　3:100978　2025/04/16

    Publisher: Open Exploration Publishing

    DOI： 10.37349/eaa.2025.100978 　

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    Aim: Emerging epidemiological studies have reported a link between allergic diseases, including asthma, and depression. Evidently, the gut microbiota is involved in the pathogenesis of asthma and depression. Therefore, we investigated whether allergic lung inflammation in mice causes gut microbial dysbiosis, via the gut-brain axis, which is potentially associated with depression.Methods: Wild-type C57BL/6J female mice were sensitized with intranasal house dust mite (HDM) antigen or phosphate-buffered saline (PBS) for 6 weeks to induce chronic allergic lung inflammation. Sucrose preference tests were performed for assessing depression. Fecal samples were collected, and 16S ribosomal RNA gene sequencing was performed to detect differences in gut microbiota composition between the HDM and PBS groups. The distance calculation, clustering of operational taxonomic units, rarefaction analysis, and estimator calculation (α- and β-diversity) were performed.Results: There was a significant difference in β-diversity (Bray-Curtis dissimilarity, F-statistics = 6.16, p = 0.001) of the gut microbiota between HDM and PBS groups. However, there was no difference in the α-diversity. We observed multiple differentially abundant bacteria in the HDM and PBS groups. The order class Clostridia (p = 0.0036) and genus Faecalibaculum (p = 0.028) were more abundant in the HDM group, whereas the phylum Firmicutes (p = 0.037) and genera Dubosiella (p = 0.00024) and Turicibacter (p = 0.037) were more abundant in the PBS group. Notably, the relative abundance of some bacteria was correlated with the sucrose preference test results.Conclusions: Six weeks of intranasal HDM administration to mimic the chronic status of lung inflammation in asthma changed the gut microbiome in mice and was associated with depression-like behavioral changes.

  3. Inspiratory effort increases blood volume in the thoracic cavity and decreases end-expiratory lung impedance: a preliminary prospective study. International-journal

    Kazuhiro Takahashi, Ayaka Koyama, Daisuke Irimada, Akihiro Kanaya, Daisuke Konno, Yu Kaiho, Yusuke Takei, Kazutomo Saito, Yutaka Ejima, Masanori Yamauchi

    European journal of applied physiology　2025/04/03

    DOI： 10.1007/s00421-025-05767-5 　

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    PURPOSE: Passive leg raising (PLR) increases intrathoracic blood volume by redistributing blood from the lower to the upper body area. While inspiratory effort is hypothesized to have a similar effect due to pressure differences between the intrathoracic and extrathoracic cavities, direct evidence is scarce. Therefore, this study evaluated whether excessive inspiratory effort increases intrathoracic blood volume using end-expiratory lung impedance (EELI). METHODS: Volunteers, fitted with electrical impedance tomography (EIT) belts, underwent a spontaneous breathing procedure in the supine position (control step). They breathed through a specialized face mask with separated inspiration and expiration routes (one-way valves) and their EELI was continuously recorded. First, PLR was performed. Subsequently, resistors (3-mm and 2-mm) were sequentially added to the mask's inspiration route, requiring volunteers to increase inspiratory effort. A reference EELI was established during spontaneous breathing, and changes in EELI (ΔEELI) were calculated for each step (control, PLR, 3-mm, and 2-mm). ΔEELI values were compared using the Friedman test and Wilcoxon signed-rank test with Holm's P value adjustment. RESULTS: Across 11 participants, the mean ΔEELI decreased by 13, 18, and 19 units for PLR, 3-mm, and 2-mm resistors, respectively. The Friedman test and Wilcoxon signed-rank test revealed significant differences between the control and each aforementioned intervention. CONCLUSION: PLR and increased inspiratory effort augment thoracic blood volume, thereby reducing EELI. REGISTRATION: UMIN000054238. April/23/2024.

  4. Quantification of muscle tone by using shear wave velocity during an anaesthetic induction: a prospective observational study. International-journal

    Hidehisa Saito, Shigekazu Sugino, Shoichiro Moteki, Akihiro Kanaya, Masanori Yamauchi

    BMC anesthesiology　23　(1)　388-388　2023/11/29

    DOI： 10.1186/s12871-023-02358-9 　

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    OBJECTIVES: The quantitative assessment of muscle stiffness or weakness is essential for medical care. Shear wave elastography is non-invasive ultrasound method and provides quantitative information on the elasticity of soft tissue. However, the universal velocity scale for quantification has not been developed. The aim of the study is to determine the shear wave velocities of abdominal muscle during anesthetic induction and to identify methods to cancel the effects of confounders for future development in the quantitative assessment of muscle tone using the universal scale. METHODS: We enrolled 75 adult patients undergoing elective surgery with ASA-PS I - III in the period between December 2018 and March 2021. We measured and calculated the shear wave velocity (SWV) before and after opioid administration (i.e., the baseline at rest and opioid-induced rigidity condition), and after muscle relaxant administration (i.e., zero reference condition). The SWV value was adjusted for the subcutaneous fat thickness by our proposed corrections. The SWVs after the adjustment were compared among the values in baseline, rigidity, and relaxation using one-way repeated-measures ANOVA and post hoc Tukey-Kramer test. A p-value of < 0.05 was considered to be statistically significant. UMIN Clinical Trials Registry identifier UMIN000034692, registered on October 30, 2018. RESULTS: The SWVs in the baseline, opioid-induced rigidity, and muscle relaxation conditions after the adjustment were 2.08 ± 0.48, 2.41 ± 0.60, and 1.79 ± 0.30 m/s, respectively (p < 0.001 at all comparisons). CONCLUSION: The present study suggested that the SWV as reference was 1.79 m/s and that the SWVs at rest and opioid-induced rigidity were ~ 10% and ~ 30% increase from the reference, respectively. The SWV adjusted for the subcutaneous fat thickness may be scale points for the assessment of muscle tone.

  5. 気道確保困難が予想された小児喉頭疾患の2例

    小池 滋, 尾形 優子, 齊藤 和智, 舟橋 優太郎, 齋藤 秀悠, 金谷 明浩, 外山 裕章, 山内 正憲

    日本小児麻酔学会誌　29　(Suppl.)　156-156　2023/10

    Publisher: (一社)日本小児麻酔学会

    ISSN： 1341-5603

  6. Association between the Depth of Sevoflurane or Propofol Anesthesia and the Incidence of Emergence Agitation in Children: A Single-Center Retrospective Study.

    Akihiro Kanaya, Takahiro Mihara, Shoma Tanaka, Maya Mikami, Toshihiro Wagatsuma, Masanori Yamauchi

    The Tohoku journal of experimental medicine　260　(2)　93-98　2023/03/09

    DOI： 10.1620/tjem.2023.J018 　

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    In the present study, we investigated the hypothesis that the depth of general anesthesia affects emergence agitation (EA) in children in the early postanesthetic period. We retrospectively examined male and female children (aged 1-9 years) who underwent ambulatory surgery that lasted < 2 h. Various parameters, including the modified Yale Preoperative Anxiety Score (mYPAS) before anesthesia induction, the Pediatric Anesthesia Emergence Delirium (PAED) score at recovery time, and the value of the patient state index (PSI), were extracted from our electronic anesthesia database. The relationships between the PAED score and the mean PSI values were examined with univariate analyses. We also investigated the associations among the mean PSI, propofol anesthesia, age, mYPAS, the type of surgery, and the total amount of fentanyl divided by body weight with the PAED score using multiple regression analysis with interaction terms. There were 32 and 34 patients in the sevoflurane and propofol groups, respectively. The PAED scores (all patients: r = -0.34, p = 0.0048; sevoflurane group: r = -0.37, p = 0.036) were negatively correlated with the mean PSI, whereas the PAED score in the propofol group [r = 0.31 (-0.03, 0.59), p = 0.073] did not show a significant positive correlation with the mean PSI in the univariate analysis. The multiple linear regression analysis outcomes revealed that the mean PSI value was an independent clinical factor associated with the PAED score. Intraoperative electroencephalogram monitoring may be proved as one of the useful tools for the assessment of EA risks in children.

  7. 剪断波速度を用いた筋緊張の定量化 麻酔導入時における前向き観察研究

    高桑 こころ, 杉野 繁一, 齋藤 秀悠, 金谷 明浩, 茂木 章一郎, 山内 正憲

    日本臨床麻酔学会誌　42　(6)　S181-S181　2022/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

    eISSN： 1349-9149

  8. Chronic allergic lung inflammation negatively influences neurobehavioral outcomes in mice

    Akihiro Kanaya, Mu Yang, Charles Emala, Maya Mikami

    Journal of Neuroinflammation　19　(1)　2022/08/31

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12974-022-02575-y 　

    eISSN： 1742-2094

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    Abstract Background Asthma is a major public health problem worldwide. Emerging data from epidemiological studies show that allergies and allergic diseases may be linked to anxiety, depression and cognitive decline. However, little is known about the effect of asthma, an allergic lung inflammation, on cognitive decline/behavioral changes. Therefore, we investigated the hypothesis that allergic lung inflammation causes inflammation in the brain and leads to neurobehavioral changes in mice. Methods Wild-type C57BL/6J female mice were sensitized with nasal house dust mite (HDM) antigen or control PBS for 6 weeks to induce chronic allergic lung inflammation. A series of neurocognitive tests for anxiety and/or depression were performed before and after the intranasal HDM administration. After the behavior tests, tissues were harvested to measure inflammation in the lungs and the brains. Results HDM-treated mice exhibited significantly increased immobility times during tail suspension tests and significantly decreased sucrose preference compared with PBS controls, suggesting a more depressed and anhedonia phenotype. Spatial memory impairment was also observed in HDM-treated mice when assessed by the Y-maze novel arm tests. Development of lung inflammation after 6 weeks of HDM administration was confirmed by histology, bronchoalveolar lavage (BAL) cell count and lung cytokine measurements. Serum pro-inflammatory cytokines and Th2-related cytokines levels were elevated in HDM-sensitized mice. In the brain, the chemokine fractalkine was increased in the HDM group. The c-Fos protein, a marker for neuronal activity, Glial Fibrillary Acidic Protein (GFAP) and chymase, a serine protease from mast cells, were increased in the brains from mice in HDM group. Chymase expression in the brain was negatively correlated with the results of sucrose preference rate in individual mice. Conclusions 6 weeks of intranasal HDM administration in mice to mimic the chronic status of lung inflammation in asthma, caused significant inflammatory histological changes in the lungs, and several behavioral changes consistent with depression and altered spatial memory. Chymase and c-Fos proteins were increased in the brain from HDM-treated mice, suggesting links between lung inflammation and brain mast cell activation, which could be responsible for depression-like behavior.

  9. Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

    COVIDSurg Collaborative, GlobalSurg Collaborative

    Anaesthesia　76　(11)　1454-1464　2021/11

    Publisher: Wiley

    DOI： 10.1111/anae.15560 　

    ISSN： 0003-2409

    eISSN： 1365-2044

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    Summary We aimed to determine the impact of pre‐operative isolation on postoperative pulmonary complications after elective surgery during the global SARS‐CoV‐2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre‐defined sub‐group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS‐CoV‐2 infection. Patients who isolated pre‐operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS‐CoV‐2 incidence and high‐income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre‐operative testing; use of COVID‐19‐free pathways; or community SARS‐CoV‐2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.

  10. Effects of oxytocin on responses to nociceptive and non-nociceptive stimulation in the upper central nervous system. International-journal

    Hidehisa Saito, Shizu Hidema, Ayano Otsuka, Jun Suzuki, Michio Kumagai, Akihiro Kanaya, Toru Murakami, Yusuke Takei, Kazutomo Saito, Shigekazu Sugino, Hiroaki Toyama, Ryuta Saito, Teiji Tominaga, Katsuhiko Nishimori, Masanori Yamauchi

    Biochemical and biophysical research communications　574　8-13　2021/10/15

    DOI： 10.1016/j.bbrc.2021.08.042 　

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    Oxytocin is known as a social bonding hormone, but it also functions as an anxiolytic or analgesic neurotransmitter. When oxytocin regulates pain or anxiousness centrally as a neurotransmitter, it is secreted by neurons and directly projected to targeted regions. Although the function of oxytocin at the spinal level is well studied, its effects at the supraspinal level are poorly understood. We aimed to investigate the effect of oxytocin at the supraspinal level in vivo using C57BL/6J (wild-type [WT]), oxytocin-deficient (Oxt-/-), oxytocin receptor-deficient (Oxtr-/-), and oxytocin receptor-Venus (OxtrVenus/+) mice lines. Response thresholds in Oxtr-/- mice in Hargreaves and von-Frey tests were significantly lower than those in WT mice, whereas open field and light/dark tests showed no significant differences. Moreover, response thresholds in Oxt-/- mice were raised to those in WT mice after oxytocin administration. Following the Hargreaves test, we observed the co-localisation of c-fos with Venus or the oxytocin receptor in the periaqueductal gray (PAG), medial amygdala (MeA), and nucleus accumbens (NAc) regions in OxtrVenus/+ mice. Furthermore, in the PAG, MeA, and NAc regions, the co-localisation of oxytocin with c-fos and gamma-aminobutyric acid was much stronger in Oxtr-/- mice than in WT mice. However, following von-Frey test, the same findings were observed only in the MeA and NAc regions. Our results suggest that oxytocin exerts its analgesic effect on painful stimulation via the PAG region and a self-protective effect on unpleasant stimulation via the MeA and NAc regions.

  11. 日本版敗血症ガイドライン2020;PAD・神経集中治療を知る PADのEvidence解説 PADISを日本の敗血症管理に適合する診療ガイドラインを目指して Peer-reviewed

    青木 善孝, 土井 松幸, 鶴田 良介, 櫻谷 正明, 鈴木 武志, 布宮 伸, 武田 親宗, 米倉 寛, 對東 俊介, 大内 玲, 櫻本 秀明, 金畑 圭太, 壽原 朋宏, 加藤 弘美, 藤村 直幸, 鈴木 佑二, 牧 盾, 柏浦 正広, 田中 裕記, 藤田 基, 金谷 明浩, 江木 盛時, 小倉 裕司, 西田 修, 田中 裕, J-SSCG2020特別委員会

    日本集中治療医学会雑誌　28　(Suppl.2)　186-186　2021/09

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  12. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020). International-journal

    Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime, Takumi Taniguchi, Ryosuke Tsuruta, Kent Doi, Matsuyuki Doi, Taka-Aki Nakada, Masaki Nakane, Seitaro Fujishima, Naoto Hosokawa, Yoshiki Masuda, Asako Matsushima, Naoyuki Matsuda, Kazuma Yamakawa, Yoshitaka Hara, Masaaki Sakuraya, Shinichiro Ohshimo, Yoshitaka Aoki, Mai Inada, Yutaka Umemura, Yusuke Kawai, Yutaka Kondo, Hiroki Saito, Shunsuke Taito, Chikashi Takeda, Takero Terayama, Hideo Tohira, Hideki Hashimoto, Kei Hayashida, Toru Hifumi, Tomoya Hirose, Tatsuma Fukuda, Tomoko Fujii, Shinya Miura, Hideto Yasuda, Toshikazu Abe, Kohkichi Andoh, Yuki Iida, Tadashi Ishihara, Kentaro Ide, Kenta Ito, Yusuke Ito, Yu Inata, Akemi Utsunomiya, Takeshi Unoki, Koji Endo, Akira Ouchi, Masayuki Ozaki, Satoshi Ono, Morihiro Katsura, Atsushi Kawaguchi, Yusuke Kawamura, Daisuke Kudo, Kenji Kubo, Kiyoyasu Kurahashi, Hideaki Sakuramoto, Akira Shimoyama, Takeshi Suzuki, Shusuke Sekine, Motohiro Sekino, Nozomi Takahashi, Sei Takahashi, Hiroshi Takahashi, Takashi Tagami, Goro Tajima, Hiroomi Tatsumi, Masanori Tani, Asuka Tsuchiya, Yusuke Tsutsumi, Takaki Naito, Masaharu Nagae, Ichiro Nagasawa, Kensuke Nakamura, Tetsuro Nishimura, Shin Nunomiya, Yasuhiro Norisue, Satoru Hashimoto, Daisuke Hasegawa, Junji Hatakeyama, Naoki Hara, Naoki Higashibeppu, Nana Furushima, Hirotaka Furusono, Yujiro Matsuishi, Tasuku Matsuyama, Yusuke Minematsu, Ryoichi Miyashita, Yuji Miyatake, Megumi Moriyasu, Toru Yamada, Hiroyuki Yamada, Ryo Yamamoto, Takeshi Yoshida, Yuhei Yoshida, Jumpei Yoshimura, Ryuichi Yotsumoto, Hiroshi Yonekura, Takeshi Wada, Eizo Watanabe, Makoto Aoki, Hideki Asai, Takakuni Abe, Yutaka Igarashi, Naoya Iguchi, Masami Ishikawa, Go Ishimaru, Shutaro Isokawa, Ryuta Itakura, Hisashi Imahase, Haruki Imura, Takashi Irinoda, Kenji Uehara, Noritaka Ushio, Takeshi Umegaki, Yuko Egawa, Yuki Enomoto, Kohei Ota, Yoshifumi Ohchi, Takanori Ohno, Hiroyuki Ohbe, Kazuyuki Oka, Nobunaga Okada, Yohei Okada, Hiromu Okano, Jun Okamoto, Hiroshi Okuda, Takayuki Ogura, Yu Onodera, Yuhta Oyama, Motoshi Kainuma, Eisuke Kako, Masahiro Kashiura, Hiromi Kato, Akihiro Kanaya, Tadashi Kaneko, Keita Kanehata, Ken-Ichi Kano, Hiroyuki Kawano, Kazuya Kikutani, Hitoshi Kikuchi, Takahiro Kido, Sho Kimura, Hiroyuki Koami, Daisuke Kobashi, Iwao Saiki, Masahito Sakai, Ayaka Sakamoto, Tetsuya Sato, Yasuhiro Shiga, Manabu Shimoto, Shinya Shimoyama, Tomohisa Shoko, Yoh Sugawara, Atsunori Sugita, Satoshi Suzuki, Yuji Suzuki, Tomohiro Suhara, Kenji Sonota, Shuhei Takauji, Kohei Takashima, Sho Takahashi, Yoko Takahashi, Jun Takeshita, Yuuki Tanaka, Akihito Tampo, Taichiro Tsunoyama, Kenichi Tetsuhara, Kentaro Tokunaga, Yoshihiro Tomioka, Kentaro Tomita, Naoki Tominaga, Mitsunobu Toyosaki, Yukitoshi Toyoda, Hiromichi Naito, Isao Nagata, Tadashi Nagato, Yoshimi Nakamura, Yuki Nakamori, Isao Nahara, Hiromu Naraba, Chihiro Narita, Norihiro Nishioka, Tomoya Nishimura, Kei Nishiyama, Tomohisa Nomura, Taiki Haga, Yoshihiro Hagiwara, Katsuhiko Hashimoto, Takeshi Hatachi, Toshiaki Hamasaki, Takuya Hayashi, Minoru Hayashi, Atsuki Hayamizu, Go Haraguchi, Yohei Hirano, Ryo Fujii, Motoki Fujita, Naoyuki Fujimura, Hiraku Funakoshi, Masahito Horiguchi, Jun Maki, Naohisa Masunaga, Yosuke Matsumura, Takuya Mayumi, Keisuke Minami, Yuya Miyazaki, Kazuyuki Miyamoto, Teppei Murata, Machi Yanai, Takao Yano, Kohei Yamada, Naoki Yamada, Tomonori Yamamoto, Shodai Yoshihiro, Hiroshi Tanaka, Osamu Nishida

    Journal of intensive care　9　(1)　53-53　2021/08/25

    DOI： 10.1186/s40560-021-00555-7 　

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    The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created as revised from J-SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in September 2020 and published in February 2021. An English-language version of these guidelines was created based on the contents of the original Japanese-language version. The purpose of this guideline is to assist medical staff in making appropriate decisions to improve the prognosis of patients undergoing treatment for sepsis and septic shock. We aimed to provide high-quality guidelines that are easy to use and understand for specialists, general clinicians, and multidisciplinary medical professionals. J-SSCG 2016 took up new subjects that were not present in SSCG 2016 (e.g., ICU-acquired weakness [ICU-AW], post-intensive care syndrome [PICS], and body temperature management). The J-SSCG 2020 covered a total of 22 areas with four additional new areas (patient- and family-centered care, sepsis treatment system, neuro-intensive treatment, and stress ulcers). A total of 118 important clinical issues (clinical questions, CQs) were extracted regardless of the presence or absence of evidence. These CQs also include those that have been given particular focus within Japan. This is a large-scale guideline covering multiple fields; thus, in addition to the 25 committee members, we had the participation and support of a total of 226 members who are professionals (physicians, nurses, physiotherapists, clinical engineers, and pharmacists) and medical workers with a history of sepsis or critical illness. The GRADE method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members.As a result, 79 GRADE-based recommendations, 5 Good Practice Statements (GPS), 18 expert consensuses, 27 answers to background questions (BQs), and summaries of definitions and diagnosis of sepsis were created as responses to 118 CQs. We also incorporated visual information for each CQ according to the time course of treatment, and we will also distribute this as an app. The J-SSCG 2020 is expected to be widely used as a useful bedside guideline in the field of sepsis treatment both in Japan and overseas involving multiple disciplines.

  13. Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

    COVIDSurg Collaborative, GlobalSurg Collaborative

    Anaesthesia　76　(6)　748-758　2021/06

    Publisher: Wiley

    DOI： 10.1111/anae.15458 　

    ISSN： 0003-2409

    eISSN： 1365-2044

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    Summary Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection were compared with those without previous SARS‐CoV‐2 infection. The primary outcome measure was 30‐day postoperative mortality. Logistic regression models were used to calculate adjusted 30‐day mortality rates stratified by time from diagnosis of SARS‐CoV‐2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre‐operative SARS‐CoV‐2 diagnosis. Adjusted 30‐day mortality in patients without SARS‐CoV‐2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre‐operative SARS‐CoV‐2 diagnosis, mortality was increased in patients having surgery within 0–2 weeks, 3–4 weeks and 5–6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3–4.8), 3.9 (2.6–5.1) and 3.6 (2.0–5.2), respectively). Surgery performed ≥ 7 weeks after SARS‐CoV‐2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9–2.1)). After a ≥ 7 week delay in undertaking surgery following SARS‐CoV‐2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2–8.7) vs. 2.4% (95%CI 1.4–3.4) vs. 1.3% (95%CI 0.6–2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS‐CoV‐2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

  14. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大塲 瑠璃, 亀山 良亘, 志賀 卓弥, 金谷 明浩, 武井 祐介, 齋藤 浩二, 山内 正憲

    日本集中治療医学会雑誌　28　(3)　222-223　2021/05

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  15. 日本版敗血症診療ガイドライン2020;PAD・神経集中治療を知る PADのEvidence解説 PADISを日本の敗血症管理に適合する診療ガイドラインを目指して

    青木 善孝, 土井 松幸, 鶴田 良介, 櫻谷 正明, 鈴木 武志, 布宮 伸, 武田 親宗, 米倉 寛, 對東 俊介, 大内 玲, 櫻本 秀明, 金畑 圭太, 壽原 朋宏, 加藤 弘美, 藤村 直幸, 鈴木 佑二, 牧 盾, 柏浦 正広, 田中 裕記, 藤田 基, 金谷 明浩, 江木 盛時, 小倉 裕司, 西田 修, 田中 裕, J-SSCG2020特別委員会PAD班

    日本集中治療医学会雑誌　27　(Suppl.)　263-263　2020/09

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  16. 日本版敗血症診療ガイドライン2020;PAD・神経集中治療を知る 痛み、不穏、せん妄管理の推奨解説

    土井 松幸, 鶴田 良介, 櫻谷 正明, 青木 善孝, 鈴木 武志, 布宮 伸, 武田 親宗, 米倉 寛, 對東 俊介, 大内 玲, 櫻本 秀明, 金畑 圭太, 壽原 朋宏, 加藤 弘美, 藤村 直幸, 鈴木 佑二, 牧 盾, 柏浦 正広, 田中 裕記, 藤田 基, 金谷 明浩, 江木 盛時, 小倉 裕司, 西田 修, 田中 裕, 日本版敗血症診療ガイドライン特別委員会PAD管理班

    日本集中治療医学会雑誌　27　(Suppl.)　263-263　2020/09

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  17. 上肢骨折手術における腕神経叢ブロックの必要性に関する麻酔科医および整形外科医の意識調査 Peer-reviewed

    舟橋 優太郎, 金谷 明浩, 宇井 あかね, 民井 亨, 白井 雄, 山内 正憲

    麻酔　69　(2)　204-209　2020/02

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  18. Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics Peer-reviewed

    Akihiro Kanaya, Toshihiro Sato, Nobuo Fuse, Hiroaki Yamaguchi, Nariyasu Mano, Masanori Yamauchi

    Journal of Anesthesia　32　(2)　236-243　2018/04/01

    Publisher: Springer Tokyo

    DOI： 10.1007/s00540-018-2470-3 　

    ISSN： 1438-8359 0913-8668

  19. A successful case of pediatric acute fulminant myocarditis with recovery using fast induction of central extracorporeal membrane oxygenation

    Kanaya Akihiro, Kameyama Yoshinobu, Takei Yusuke, Shiga Takuya, Wagatsuma Toshihiro, Ejima Yutaka, Saito Koji, Yamauchi Masanori

    Journal of the Japanese Society of Intensive Care Medicne　25　(3)　197-198　2018

    Publisher: 一般社団法人 日本集中治療医学会

    ISSN： 1340-7988

  20. Factors affecting extubation time following pediatric ambulatory surgery: an analysis using electronic anesthesia records from an academic university hospital. International-journal Peer-reviewed

    Kanaya A, Kuratani N, Nakata Y, Yamauchi M

    JA clinical reports　3　(1)　38-38　2017

    DOI： 10.1186/s40981-017-0108-3 　

    More details Close

    BACKGROUND: In pediatric general anesthesia, our goal should be quicker extubation to facilitate rapid turnover in the operating room without compromising on safety and quality of anesthesia. Although many studies have focused on improving safety and pursuing a higher quality of recovery, factors related to anesthesia emergence remain unclear. We must, therefore, identify factors that influence the process of emergence from general anesthesia in children. FINDINGS: We retrospectively examined 148 children (aged 1-6 years, American Society of Anesthesiologists physical status: 1-2) who had undergone <2 h of ambulatory surgery. Clinical measures included time from the end of surgery to extubation (extubation time), age, height, weight, surgical time, mean indirect blood pressure during surgery, mean heart rate during surgery, mean end-tidal carbon dioxide during surgery (mETCO2), mean body temperature during surgery (mBT), and total amount of fentanyl. Anesthetic procedures involved sevoflurane or propofol. Multiple regression analysis revealed that mETCO2 (p < 0.01) and mBT (p < 0.01) were independent clinical factors associated with extubation time following pediatric ambulatory surgery. CONCLUSIONS: This study of 148 pediatric patients demonstrated that anesthesia emergence may be associated with mBT and mETCO2 following pediatric ambulatory surgery. These results show that perioperative vital signs are important in the prevention of delayed emergence for pediatric patients.

  21. Intraoperative hypercapnia and anesthesia emergence after pediatric ambulatory surgery Peer-reviewed

    Akihiro Kanaya, Norifumi Kuratani, Yu Kaiho, Masanori Yamauchi

    PEDIATRIC ANESTHESIA　26　(11)　1116-1117　2016/11

    DOI： 10.1111/pan.12984 　

    ISSN： 1155-5645

    eISSN： 1460-9592

  22. 高機能手術室の功罪 ハイブリッド手術室・高機能手術室の展望

    江島 豊, 金谷 明浩, 志賀 卓弥, 山内 正憲

    日本手術医学会誌　37　(2)　86-89　2016/05

    Publisher: 日本手術医学会

    ISSN： 1340-8593

  23. 手術室における震災避難訓練

    金谷 明浩, 山内 正憲, 江島 豊, 阿部 望

    蘇生　35　(1)　23-26　2016/04

    Publisher: 日本蘇生学会

    DOI： 10.11414/jjreanimatology.35.1_23 　

    ISSN： 0288-4348

    eISSN： 1884-748X

  24. Emergence agitation in children: risk factors, prevention, and treatment Peer-reviewed

    Akihiro Kanaya

    JOURNAL OF ANESTHESIA　30　(2)　261-267　2016/04

    DOI： 10.1007/s00540-015-2098-5 　

    ISSN： 0913-8668

    eISSN： 1438-8359

  25. 人工呼吸管理後に新規のテロメラーゼ遺伝子多型を同定できた家族性肺繊維症の妊婦の1症例

    杉野 繁一, 金谷 明浩, 山内 正憲

    日本集中治療医学会雑誌　23　(Suppl.)　769-769　2016/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  26. 超ハイリスク患者への術前説明の現状と課題

    阿部 望, 金谷 明浩, 江島 豊, 山内 正憲

    蘇生　34　(3)　265-265　2015/10

    Publisher: 日本蘇生学会

    DOI： 10.11414/jjreanimatology.34.3_265b 　

    ISSN： 0288-4348

    eISSN： 1884-748X

  27. 本邦における麻酔器トラブル事例の検討

    金谷 明浩, 山内 正憲, 江島 豊

    蘇生　34　(2)　94-97　2015/08

    Publisher: 日本蘇生学会

    DOI： 10.11414/jjreanimatology.34.94 　

    ISSN： 0288-4348

  28. 小児麻酔 覚醒時興奮

    金谷 明浩, 亀山 良亘, 山内 正憲, 蔵谷 紀文

    日本臨床麻酔学会誌　34　(5)　739-744　2014/09

    Publisher: 日本臨床麻酔学会

    DOI： 10.2199/jjsca.34.739 　

    ISSN： 0285-4945

  29. Lower incidence of emergence agitation in children after propofol anesthesia compared with sevoflurane: a meta-analysis of randomized controlled trials Peer-reviewed

    Akihiro Kanaya, Norifumi Kuratani, Daizoh Satoh, Shin Kurosawa

    JOURNAL OF ANESTHESIA　28　(1)　4-11　2014/02

    DOI： 10.1007/s00540-013-1656-y 　

    ISSN： 0913-8668

    eISSN： 1438-8359

  30. Emergence Agitation in Children after General Anesthesia

    KANAYA Akihiro, KAMEYAMA Yoshinobu, YAMAUCHI Masanori, KURATANI Norifumi

    JJSCA　34　(5)　739-744　2014

    Publisher: 日本臨床麻酔学会

    DOI： 10.2199/jjsca.34.739 　

    ISSN： 0285-4945

    More details Close

    &amp;nbsp;&amp;nbsp;Emergence agitation (EA) following general anesthesia in children is an evolving problem because it can injure both the patient and the caregiver and decrease the parent&#039;s satisfaction. Risk factors for emergence agitation include age, preoperative anxiety, the character of the patient, pain, the operative procedure, and the anesthetics used. Maintenance of anesthesia with sevoflurane is a major risk factor for EA, whereas propofol maintenance allows for calm wake-up, smooth and rapid recovery profile, and few postoperative side effects. Perioperative medications including opioids, midazolam, alpha-2 agonists, ketamine, and non-steroidal anti-inflammatory drugs are effective for avoiding EA. Anesthesiologists should prevent EA following pediatric anesthesia by considering the risk factors and appropriate selection of anesthetics.

  31. Higher fraction of inspired oxygen in anesthesia induction does not affect functional residual capacity reduction after intubation: a comparative study of higher and lower oxygen concentration Peer-reviewed

    Akihiro Kanaya, Daizoh Satoh, Shin Kurosawa

    JOURNAL OF ANESTHESIA　27　(3)　385-389　2013/06

    DOI： 10.1007/s00540-012-1547-7 　

    ISSN： 0913-8668

  32. リンパ管平滑筋腫症に対する脳死片肺移植術後に生じた再膨張性肺水腫の一例

    金谷 明浩, 齋藤 浩二, 志賀 卓弥, 亀山 良亘, 吾妻 俊弘, 佐藤 大三, 星 邦彦

    日本集中治療医学会雑誌　20　(2)　275-276　2013/04

    Publisher: (一社)日本集中治療医学会

    DOI： 10.3918/jsicm.20.275 　

    ISSN： 1340-7988

    eISSN： 1882-966X

  33. The influence of tidal volume on functional residual capacity during general anesthesia Peer-reviewed

    Akihiro Kanaya, Daizoh Satoh, Shin Kurosawa

    Japanese Journal of Anesthesiology　60　(10)　1149-1152　2011/10/10

    ISSN： 0021-4892

  34. Airway management in a patient with Williams syndrome Peer-reviewed

    Akihiro Kanaya, Tadanobu Yasuda, Akiko Kojima, Toshio Saishu, Shin Kurosawa

    Japanese Journal of Anesthesiology　60　(10)　1176-1179　2011/10/10

    ISSN： 0021-4892

  35. ウィリアムス症候群の気道管理

    金谷 明浩, 安田 忠伸, 小島 晶子, 最首 俊夫, 黒澤 伸

    麻酔　60　(10)　1176-1179　2011/10

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

  36. 麻酔中の1回換気量の違いが機能的残気量に及ぼす影響

    金谷 明浩, 佐藤 大三, 黒澤 伸

    麻酔　60　(10)　1149-1152　2011/10

    Publisher: 克誠堂出版(株)

    ISSN： 0021-4892

Show all ︎Show first 5

Misc. 19

  1. 脳死肝移植再灌流時の心電図変化

    江島豊, 江島豊, 外山裕章, 海法悠, 金谷明浩, 齊藤和智, 山内正憲

    日本集中治療医学会学術集会(Web)　51st　2024

  2. 新型コロナ肺炎の重症病態での凝固障害への治療戦略 rotational thromboelastometry(ROTEM)使用の経験

    岩崎 夢大, 山内 正憲, 阿部 望, 金谷 明浩

    蘇生　39　(3)　193-193　2020/10

    Publisher: 日本蘇生学会

    ISSN： 0288-4348

    eISSN： 1884-748X

  3. 全身麻酔導入時の気管挿管困難・換気困難により外科的気道確保を行った症例の検討

    佐々木 亜美, 金谷 明浩, 阿部 望, 江島 豊, 山内 正憲

    蘇生　37　(3)　226-226　2018/10

    Publisher: 日本蘇生学会

    ISSN： 0288-4348

  4. 若年者上顎骨・下顎骨形成術における動脈圧心拍出量測定センサーを用いた術中輸液管理の検討

    鈴木 朋子, 鈴木 広隆, 金谷 明浩, 山内 正憲

    日本歯科麻酔学会雑誌　46　(抄録号)　187-187　2018/09

    Publisher: (一社)日本歯科麻酔学会

    ISSN： 0386-5835

  5. A successful case of pediatric acute fulminant myocarditis with recovery using fast induction of central extracorporeal membrane oxygenation

    金谷明浩, 亀山良亘, 武井祐介, 志賀卓弥, 吾妻俊弘, 江島豊, 齋藤浩二, 山内正憲

    日本集中治療医学会雑誌(Web)　25　(3)　197‐198(J‐STAGE)-198　2018/05

    Publisher: (一社)日本集中治療医学会

    DOI： 10.3918/jsicm.25_197 　

    ISSN： 1882-966X

  6. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大場瑠璃, 亀山良亘, 志賀卓弥, 金谷明浩, 武井祐介, 齊藤和智, 山内正憲

    日本集中治療医学会学術集会(Web)　45th　(Suppl.)　ROMBUNNO.P83‐1 (WEB ONLY)-1]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  7. 末梢神経ブロックがリハビリテーションの進捗に寄与した1例

    大塲 瑠璃, 亀山 良亘, 志賀 卓弥, 金谷 明浩, 武井 祐介, 齊藤 和智, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[P83-1]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  8. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[O69-2]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  9. endothelial microparticlesに着目した急性呼吸促迫症候群における肺血管内皮傷害の検討

    武井 祐介, 齋藤 浩二, 亀山 良亘, 齊藤 和智, 金谷 明浩, 杉野 繁一, 吾妻 俊弘, 江島 豊, 志賀 卓弥, 山内 正憲

    日本集中治療医学会雑誌　25　(Suppl.)　[O69-2]　2018/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  10. 植え込み式左心補助装置装着後,肺炎の管理に体外式膜型人工肺が有用であった一例

    藤峯拓哉, 齋藤浩二, 金谷明浩, 志賀卓弥, 亀山良亘, 山内正憲

    日本呼吸療法医学会学術総会プログラム・抄録集　40th　225　2018

  11. 手術時間延長オカレンスの検討

    江島 豊, 佐藤 裕子, 大久保 裕子, 佐伯 美保, 早川 穂乃佳, 松浦 健, 菊地 昭二, 齊藤 和智, 金谷 明浩, 志賀 卓弥, 山内 正憲

    日本手術医学会誌　38　(Suppl.)　167-167　2017/09

    Publisher: 日本手術医学会

    ISSN： 1340-8593

  12. 開胸手術後に縦隔炎を合併し、長期の経口挿管管理を要した二例

    宇井 あかね, 亀山 良亘, 吾妻 俊弘, 金谷 明浩, 武井 祐介, 江島 豊, 齋藤 浩二

    日本集中治療医学会雑誌　24　(Suppl.)　DP20-4　2017/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  13. 小児劇症型心筋炎に対し早期のCentral ECMOを導入し救命し得た1例

    金谷 明浩, 亀山 良亘, 武井 祐介, 志賀 卓弥, 吾妻 俊弘, 江島 豊, 齋藤 浩二, 山内 正憲

    日本集中治療医学会雑誌　24　(Suppl.)　O8-5　2017/02

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

    eISSN： 1882-966X

  14. 術後2週間以内に再手術を行った手術の検討

    江島 豊, 大久保 裕子, 佐藤 裕子, 金谷 明浩, 志賀 卓弥, 斎藤 和智, 山内 正憲

    日本手術医学会誌　37　(Suppl.)　80-80　2016/10

    Publisher: 日本手術医学会

    ISSN： 1340-8593

  15. 手術室における震災避難訓練

    山内 正憲, 江島 豊, 金谷 明浩, 阿部 望

    蘇生　34　(3)　276a-276a　2015/10

    Publisher: 日本蘇生学会

    DOI： 10.11414/jjreanimatology.34.3_276a 　

    ISSN： 0288-4348

  16. 麻酔器に関するオカレンスの検討

    江島 豊, 松浦 健, 菊地 昭二, 大久保 裕子, 佐藤 裕子, 金谷 明浩, 山内 正憲

    日本手術医学会誌　36　(Suppl.)　82-82　2015/09

    Publisher: 日本手術医学会

    ISSN： 1340-8593

  17. 人工呼吸器AVEAを用いて計測した死腔についての考察

    紺野 大輔, 星 邦彦, 齋藤 浩二, 亀山 良亘, 金谷 明浩, 山内 正憲

    日本集中治療医学会雑誌　21　(Suppl.)　[DP-33　2014/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  18. 片側再膨張性肺水腫に対して腹臥位人工呼吸が有効であった一例

    金谷 明浩, 齋藤 浩二, 星 邦彦, 紺野 大輔, 亀山 良亘, 吾妻 俊弘, 山内 正憲

    日本集中治療医学会雑誌　21　(Suppl.)　[DP-95　2014/01

    Publisher: (一社)日本集中治療医学会

    ISSN： 1340-7988

  19. 気管挿管後に換気困難に陥った小児巨大縦隔腫瘍の一例

    金谷 明浩, 戸田 法子, 早坂 知子, 千葉 聡子, 山内 正憲

    日本臨床麻酔学会誌　33　(6)　S260-S260　2013/10

    Publisher: 日本臨床麻酔学会

    ISSN： 0285-4945

Show all ︎Show first 5

Books and Other Publications 5

  1. 麻酔科学レビュー2025

    金谷 明浩

    総合医学者　2025/06

  2. 胸部手術の麻酔 : 一側肺換気の手技と知識を知る

    外山, 裕章, 山内, 正憲(医学)

    日本医事新報社　2021/07

    ISBN: 9784784959006

  3. すっきりフローチャートで学ぶ小児の麻酔

    五十嵐, あゆ子, 川名, 信

    克誠堂出版　2020/12

    ISBN: 9784771905399

  4. 術式対応“わがまま”術後鎮痛マニュアル．

    金谷 明浩

    克誠堂出版　2018

    ISBN: 9784771905047

  5. ポイントで学ぶ小児麻酔５０症例．

    金谷 明浩

    克誠堂出版　2017

    ISBN: 9784771904934

Presentations 36

  1. 胸部デジタルX線動態撮影システムによる肺移植術後横隔膜機能低下の検討：単施設後ろ向き観察研究（優秀演題）

    田中捷馬, 金谷明浩, 田中亜美, 髙橋和博, 入間田大介, 藤秀悠, 高木英誠, 小林直也, 紺野大輔, 山内正憲

    日本集中治療医学会 第9回東北支部学術集会　2025/07/12

  2. 胸部デジタル線動態撮影システムは心臓血管外科術後の換気の左右差を明らかにする

    田中捷馬, 金谷明浩, 齋藤秀悠, 高木英誠, 山内正憲

    日本麻酔科学会 第72回学術集会　2025/06/05

  3. A Case of Ventilation Assessment Using a Digital Dynamic Radiography System (DDR) Following Brain-Dead Donor Double Lung Transplantation

    Akihiro Kanaya, Shoma Tanaka, Hidehisa Saito, Elvedin Luković, Masanori Yamauchi

    2025 Annual Meeting, presented by IARS and SOCCA　2025/03/22

  4. 生体両肺移植術後の換気の評価にデジタルX線動画撮影システムを用いた1症例

    金谷明浩, 田中捷馬, 髙橋和博, 舟橋優太郎, 齋藤秀悠, 入間田大介, 小林直也, 紺野大輔, 江島豊, 山内正憲

    第52回日本集中治療医学会学術集会　2025/03/14

  5. 肺移植術後の呼吸管理におけるデジタルX線動画撮影システムの有効性 Invited

    金谷明浩

    DDR臨床セミナー（胸部単純画像の基本からX線動態画像の臨床での活用まで）　2025/02/22

  6. 脳死両肺移植術後の換気の評価にデジタルX線動画撮影システムを用いた1症例（優秀演題）

    金谷明浩、田中捷馬、田中亜美、齋藤秀悠、入間田大介、高木英誠、小林直也、紺野大輔、江島豊、山内正憲

    日本集中治療医学会第8回東北支部学術集会　2024/07/27

  7. A Peptide Fragment Of The Actin-binding Protein Gelsolin Attenuates Ige-mediated Mast Cell Degranulation In Vitro And Murine Mast Cell CalciumOscillations Ex Vivo

    M. Mikami, A. Kanaya, K. Dantzler, J. Perez-Zoghbi, C. W. Emala

    ATS2024 International Conference　2024/05/22

  8. マウスにおけるハウスダストマイト投与は神経活性を低下させる（優秀演題）

    金谷 明浩, Charles Emala, Maya Mikami

    第13回日本麻酔科学会北海道・東北支部学術集会　2023/09/09

  9. Chronic Allergic Lung InflammationInduced by Intranasal House Dust MiteAntigen Causes Suppression of NeuronalActivity in Mice

    M. Trichas, A. Kanaya, K. Chen, G. Yang, C. W. Emala, M. Mikami

    ATS2023 International Conference　2023/05/22

  10. Allergic Lung Inflammation on Gut Microbiota and Depression in Mice

    Akihiro Kanaya, Elvedin Luković, Charles Emala, Maya Mikami

    ATS2023 International Conference　2023/05/22

  11. Chronic Allergic Lung Inflammation Negatively Influences Neurobehavioral Outcomes in Mice

    Akihiro Kanaya, Charles Emala, Maya Mikami

  12. The Effect of Genetic Polymorphisms on Individual Differences in Propofol Pharmacokinetics Among Japanese Patients

    Akihiro Kanaya, M.D.,Ph.D, Masafumi Kikuchi, Ph.D, Nobuo Fuse, M.D.,Ph.D, Masanori Yamauchi, M.D.,Ph.D

    The Anesthesiology annual meeting　2020/10/03

  13. プロポフォール体内動態と遺伝子多型

    金谷 明浩

    第66回日本麻酔科学会学術集会　2019/05/31

  14. 全身麻酔導入時の気管挿管困難・換気困難により外科的気道確保を行った症例の検討

    佐々木 亜美, 金谷 明浩, 阿部 望, 江島 豊, 山内 正憲

    第３７回日本蘇生学会　2018/11/16

  15. 術前心機能がヘパリン静注後の活性化凝固時間に与える影響

    高橋 和博, 金谷 明浩, 岡田 茂吉, 菊池 由希子, 武中 敏恵, 山内 正憲

    日本麻酔科学会 北海道・東北支部第8回学術集会　2018/09/01

  16. 上肢骨折手術における腕神経叢ブロックの必要性に関する麻酔科医および整形外科医の意識調査

    舟橋 優太郎, 金谷 明浩, 宇井 あかね, 民井 亨, 仁田原 美知子, 山内 正憲

    第65回日本麻酔科学会学術集会　2018/05/18

  17. ゲノムワイド関連分析によるプロポフォール体内動態の分子遺伝学的解明

    金谷 明浩, 山内 正憲

    第65回日本麻酔科学会学術集会　2018/05/17

  18. ゲノムワイド関連分析によるプロポフォール体内動態の分子遺伝学的解明

    金谷 明浩, 山内 正憲

    第64回日本麻酔科学会学術集会　2017/06/10

  19. プロポフォールの血中濃度に影響を与える因子の検討

    金谷 明浩, 佐藤 紀宏, 布施 昇男, 山口 浩明, 眞野 成康, 山内 正憲

    第64回日本麻酔科学会学術集会　2017/06/09

  20. 小児における麻酔覚醒時間に影響を与える因子の検討

    金谷 明浩, 蔵谷 紀文, 民井 亨, 戸田 法子, 遠藤 康弘, 山内 正憲

    第64回日本麻酔科学会学術集会　2017/06/08

  21. 小児劇症型心筋炎に対し早期のCentral ECMOを導入し救命し得た1例

    金谷 明浩, 亀山 良亘, 武井 祐介, 志賀 卓弥, 吾妻 俊弘, 江島 豊, 齋藤 浩二, 山内 正憲

    2017/03

  22. Factors affecting extubation time following pediatric amburatory surgery: an analysis using electronic anesthesia record data in an academic university hospital. International-presentation

    Akihiro Kanaya

    2015/10

  23. 小児全身麻酔における抜管時間に影響を与える因子の検討

    金谷 明浩, 杉野 繁一, 海法 悠, 蔵谷 紀文, 遠藤 康弘, 山内 正憲

    日本麻酔科学会 北海道・東北支部第5回学術集会　2015/09

  24. 小児覚醒時興奮 Invited

    金谷 明浩

    第62回日本麻酔科学会学術集会　2015/05

  25. 手術中のPEEPが機能的残気量とPaO2に与える影響

    金谷 明浩, 佐藤 大三, 民井 亨, 岡田 茂吉, 山内 正憲

    第36回日本呼吸療法医学会学術集会　2014/07

  26. 片側再膨張性肺水腫に対して腹臥位人工呼吸が有効であった一例

    金谷 明浩, 齋藤 浩二, 星 邦彦, 紺野 大輔, 亀山 良亘, 吾妻 俊弘, 山内 正憲

    日本集中治療医学会雑誌　2014/02

  27. 気管挿管後に換気困難に陥った小児巨大縦隔腫瘍の一例

    金谷 明浩, 戸田 法子, 早坂 知子, 千葉 聡子, 山内 正憲

    日本臨床麻酔学会誌　2013/11

  28. 覚醒時興奮 Invited

    金谷 明浩

    日本臨床麻酔学会誌　2013/11

  29. 感染性心内膜炎のため心臓手術を行った42例の後ろ向き調査

    金谷 明浩, 星 邦彦, 阿部 望, 齊藤 浩二, 亀山 良亘, 吾妻 俊弘, 江島 豊, 山内 正憲

    第22回日本集中治療医学会東北地方会　2013/07

  30. Lower incidence of emergence agitation in children after propofol anesthesia as compared with sevoflurane: a meta-analysis of randomized controlled trials. International-presentation

    Kanaya A, Kuratani N, Satoh D, Kurosawa S

    2012 American Society Of Anesthesiologists Annual Meeting　2012/10

  31. リンパ管平滑筋腫症に対する脳死片肺移植術後に生じた再膨張性肺水腫の一例

    金谷 明浩, 齊藤 浩二, 志賀 卓弥, 吾妻 俊弘, 佐藤 大三, 星 邦彦

    第21回日本集中治療医学会東北地方会　2012/07

  32. 東日本大震災におけるみやぎ県南中核病院の対応

    金谷 明浩, 安田 忠信, 小島 晶子, 最首 俊夫

    第59回日本麻酔科学会学術集会　2012/06

  33. Oxygen Concentration and Functional Residual Capacity During General Anesthesia International-presentation

    Kanaya A, Satoh D, Suzuki M, Saito K, Konodo N

    2011 American Society of Anesthesiologists Annual Meeting　2011/10

  34. 腹腔鏡下右半結腸切除術後に判明した皮下気腫による術中の高二酸化炭素の一例

    金谷 明浩, 安田 忠信, 小島 晶子, 最首 俊夫

    日本麻酔科学会 第1回北海道・東北支部学術集会　2011/09

  35. 麻酔中の一回換気量の違いが機能的残気量に与える影響

    金谷 明浩, 佐藤 大三, 外山 裕章, 武井 祐介, 齋藤 浩二, 黒澤 伸

    日本麻酔科学会 第67回東北支部学術集会　2010/09

  36. Suppression of mast cell activation prevents behavioral changes observed in mice with chronic allergic lung inflammation

    AUA 2025 Annual Meeting 2025.03.07-09　2025/03/07

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Research Projects 3

  1. 胸部X線動態撮影と気道分泌物のメタボローム解析による新たな人工呼吸器離脱戦略

    Category: 若手研究

    2025/04 - 2028/03

  2. 喘息マウスモデルにおけるうつ行動と脳機能変化との関連

    Offer Organization: 東北大学

    System: 令和６年度第２回 東北大学 「若手リーダー海外派遣プログラム研究員（オンライン型）」

    Institution: 東北大学

    2024/10 - 2025/09

  3. 術後せん妄発症機序の分子遺伝学的解明

    金谷 明浩

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    Category: 若手研究

    Institution: 東北大学

    2019/04 - 2025/03

    More details Close

    我が国は超高齢化社会を迎え，高齢者の手術件数増加に伴い，術後せん妄の増加が大きな問題となっている．術後せん妄は術後の回復期に起こり，患者にとって不快な体験となるだけではなく，生存率にも大きく影響することが明らかとなってきている．しかしながら，術後せん妄を引き起こすメカニズムや根拠のある予防法・治療法については，いまだに明らかではなく，その解明は喫緊の課題である．近年，術後せん妄と一塩基多型(SNPs)の関連が示唆されている．そこで，われわれは,術後せん妄と関連のあるSNPsを遺伝子マーカーとして同定する． 術後せん妄は様々な要因の関連が示唆されている。なかでも、疼痛は一つの重要な因子とされており、上肢骨折手術における腕神経叢ブロックの必要性に関する麻酔科医および整形外科医の意識調査を行い、術後鎮痛・術後管理における調査をおこなった（麻酔 2020；69：204-9）．さらに，本研究の予備研究として，全身麻酔の導入および維持薬として用いられるプロポフォールの薬物動態にSNPsが及ぼす影響について検討した。プロポフォールの代謝に関連したグルクロン酸抱合に関する遺伝子のSNPsが薬物動態に影響を与える可能性を明らかにして，現在，論文投稿準備中である． 本研究として，日本人に最適化されたゲノム解析のプラットフォームであるSNPアレイを用いた補完的全ゲノム関連解析(GWAS)により，術後せん妄と関連のあるSNPsを遺伝子マーカーとして同定する予定であり，倫理委員会の承認を得た．