Details of the Researcher

PHOTO

Takahiro Nobukuni
Section
Tohoku Medical Megabank Organization
Job title
Associate Professor
Degree

  • 博士（理学）（東京大学）

  • 修士（理学）（東京大学）

Professional Memberships 1

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Research Areas 1

  • Life sciences / Molecular biology /

Papers 28

  1. Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes. International-journal

    Keigo Sato, Yoshitaka Nakamura, Kazuhito Fujiyama, Kinuko Ohneda, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Shinji Jinno

    Journal of food science　89　(12)　10152-10170　2024/12

    DOI： 10.1111/1750-3841.17597 　

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    Human milk oligosaccharides (HMOs) have been positively associated with child neurodevelopment in some cohort studies. However, there is a lack of consistency in the association between HMOs and benefits to infants' brains. Moreover, the quantification methods for HMOs have not yet been standardized. In this study, we developed a quantification method for evaluating eight HMOs (2'-fucosyllactose [2'-FL], 3'-fucosyllactose [3'-FL], 3'-sialyllactose [3'-SL], 6'-sialyllactose [6'-SL], lactosialyltetrasaccharide a [LSTa], lactosialyltetrasaccharide b [LSTb], lactosialyltetrasaccharide c [LSTc], and disialyllacto-N-tetraose [DSLNT]) in breast milk. After validating the method, we applied it to 1-month breast milk samples (n = 150) from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study to assess HMO profiles in breast milk and their possible association with changes in head circumference z-score (ΔHCZ) and neurodevelopmental scores of children (as measured by the Ages and Stages Questionnaire, Third Edition). The validation demonstrated that the method had relative standard deviation ≤ 12.7% of precision and 79.5-110.9% of accuracy. Using this method, eight HMO levels (2'-FL, 0-4.74 mg/mL; 3'-FL, 0.02-1.52 mg/mL; 3'-SL, 0.07-0.32 mg/mL; 6'-SL, 0.01-0.70 mg/mL; LSTa, 0.002-0.043 mg/mL; LSTb, 0.02-0.31 mg/mL; LSTc, 0.001-0.47 mg/mL; and DSLNT, 0.09-0.71 mg/mL [min-max, all participants]) and the ratio of low secretors (16.0%) in the Japanese cohort were obtained. The obtained HMO levels in breast milk were subjected to multivariate analysis to screen for HMOs showing a positive association with ΔHCZ and neurodevelopmental scores. The results proposed that ΔHCZ was positively associated with LSTb and 2'-FL levels, whereas neurodevelopmental scores were positively associated with 2'-FL levels (among all participants) and 3'-SL and DSLNT levels (among secretor participants). This study showed that the developed method provides HMO profiles in Japanese breast milk, as well as additional information on the associations between specific HMOs and neurodevelopment, reinforcing the sum of evidence for the role of HMOs in the brain.

  2. Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Kinuko Ohneda, Masashi Morifuji

    Nutrients　16　(1)　2023/12/31

    DOI： 10.3390/nu16010145 　

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    (1) Background: Breast milk is the only source of nutrition for breastfed infants, but few studies have examined the relationship between breast milk micronutrients and infant neurodevelopmental outcome in exclusively breastfed infants. The aim of this study was to characterize the association between nicotinamide adenine dinucleotide (NAD)-related compounds in the breast milk of Japanese subjects and infant neurodevelopmental outcome. (2) Methods: A total of 150 mother-child pairs were randomly selected from the three-generation cohort of the Tohoku Medical Megabank in Japan. Infants were exclusively breastfed for up to 6 months. Breast milk was collected at 1 month postpartum, and the quantity of NAD-related substances in the breast milk was quantified. The mothers also completed developmental questionnaires at 6, 12, and 24 months. The relationship between the concentration of NAD-related substances in breast milk and developmental indicators was evaluated via ordinal logistic regression analysis. (3) Results: Nicotinamide mononucleotide (NMN) was quantified as the major NAD precursor in breast milk. The median amount of NMN in the breast milk was 9.2 μM. The NMN concentration in breast milk was the only NAD-related substance in breast milk that showed a significant positive correlation with neurodevelopmental outcome in infants at 24 months. (4) Conclusions: The results suggest that NMN in human milk may be an important nutrient for early childhood development.

  3. Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information. International-journal

    Hisaaki Kudo, Noriko Ishida, Takahiro Nobukuni, Yuichi Aoki, Sakae Saito, Ichiko Nishijima, Takahiro Terakawa, Masayuki Yamamoto, Naoko Minegishi, Riu Yamashita, Kazuki Kumada

    Biopreservation and biobanking　2023/12/11

    DOI： 10.1089/bio.2022.0211 　

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    With the number of samples increasing in many biobanks, one of the most pressing tasks is recording the correct relationships between information and the specimens. Genomic information is useful in determining the identity of these specimens. The Tohoku Medical Megabank Organization is running one of the largest biobanks in Japan. Here, we introduce a management system, which includes the development of a new probe set for the MassARRAY system for use during the production of proliferating T cells (T cells) and lymphoblastoid cell lines (LCLs). We selected single nucleotide variants that could be detected by next-generation sequencing and showed high resolution with ∼0.5 minor allele frequencies. After checking the set of probes against 96 samples from 48 people, we obtained no contradictory results in comparison with our genome sequence information. When we applied the set to our 3035 LCLs and 2256 T cells, the result showed 98.93% consistency with the corresponding genomic information. We surveyed the handling records of the 1.07% of samples that showed inconsistencies, and found that most had resulted from human errors (ID swapping between samples) during manual operations. After improving a few error-prone protocols, the error rate dropped to 0.47% for LCLs and 0% for T cells. Overall, the system that we developed shows high accuracy with easy and fast operability, and provides a good opportunity to improve the validation procedure to facilitate high-quality banking, especially in cases involving genomic information.

  4. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

    Human genome variation　8　(1)　44-44　2021/12/10

    DOI： 10.1038/s41439-021-00175-5 　

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    To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

  5. Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines

    Noriko Ishida, Yuichi Aoki, Fumiki Katsuoka, Ichiko Nishijima, Takahiro Nobukuni, Hayato Anzawa, Li Bin, Miyuki Tsuda, Kazuki Kumada, Hisaaki Kudo, Takahiro Terakawa, Akihito Otsuki, Kengo Kinoshita, Riu Yamashita, Naoko Minegishi, Masayuki Yamamoto

    Free Radical Biology and Medicine　161　71-83　2020/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.freeradbiomed.2020.09.023 　

    ISSN： 0891-5849

  6. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project Peer-reviewed

    Naoko Minegishi, Ichiko Nishijima, Takahiro Nobukuni, Hisaaki Kudo, Noriko Ishida, Takahiro Terakawa, Kazuki Kumada, Riu Yamashita, Fumiki Katsuoka, Soichi Ogishima, Kichiya Suzuki, Makoto Sasaki, Mamoru Satoh, Tohoku Medical Megabank Project Study Group, Masayuki Yamamoto

    The Tohoku Journal of Experimental Medicine　248　(1)　45-55　2019

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.248.45 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  7. Amino acids activate mTOR Complex 1 via Ca2+/CaM signaling to hVps34 Peer-reviewed

    Pawan Gulati, Lawrence D. Gaspers, Stephen G. Dann, Manel Joaquin, Takahiro Nobukuni, Francois Natt, Sara C. Kozma, Andrew P. Thomas, George Thomas

    CELL METABOLISM　7　(5)　456-465　2008/05

    DOI： 10.1016/j.cmet.2008.03.002 　

    ISSN： 1550-4131

  8. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors Peer-reviewed

    Gunnar Johansson, Yonatan Y. Mahller, Margaret H. Collins, Mi-Ok Kim, Takahiro Nobukuni, John Perentesis, Timothy P. Cripe, Heidi A. Lane, Sara C. Kozma, George Thomas, Nancy Ratner

    MOLECULAR CANCER THERAPEUTICS　7　(5)　1237-1245　2008/05

    DOI： 10.1158/1535-7163.MCT-07-2335 　

    ISSN： 1535-7163

    eISSN： 1538-8514

  9. hvps34, an ancient player, enters a growing game: mTOR Complex1l/S6K1 signaling Peer-reviewed

    Takahiro Nobukuni, Sara C. Kozma, George Thomas

    CURRENT OPINION IN CELL BIOLOGY　19　(2)　135-141　2007/04

    DOI： 10.1016/j.ceb.2007.02.019 　

    ISSN： 0955-0674

    eISSN： 1879-0410

  10. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 30H-kinase Peer-reviewed

    T Nobukuni, M Joaquin, M Roccio, SG Dann, SY Kim, P Gulati, MP Byfield, JM Backer, F Natt, JL Bos, FJT Zwartkruis, G Thomas

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　102　(40)　14238-14243　2005/10

    DOI： 10.1073/pnas.0506925102 　

    ISSN： 0027-8424

  11. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 Peer-reviewed

    A Garami, FJT Zwartkruis, T Nobukuni, M Joaquin, M Roccio, H Stocker, SC Kozma, E Hafen, JL Bos, G Thomas

    MOLECULAR CELL　11　(6)　1457-1466　2003/06

    DOI： 10.1016/S1097-2765(03)00220-X 　

    ISSN： 1097-2765

  12. Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization Peer-reviewed

    S Maeda, T Nobukuni, K Shimo-Onoda, K Hayashi, K Yone, S Komiya, Inoue, I

    JOURNAL OF CELLULAR PHYSIOLOGY　193　(1)　73-79　2002/10

    DOI： 10.1002/jcp.10151 　

    ISSN： 0021-9541

  13. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent Peer-reviewed

    A Jaeschke, J Hartkamp, M Saitoh, W Roworth, T Nobukuni, A Hodges, J Sampson, G Thomas, R Lamb

    JOURNAL OF CELL BIOLOGY　159　(2)　217-224　2002/10

    DOI： 10.1083/jcb.200206108 　

    ISSN： 0021-9525

  14. Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer Peer-reviewed

    H Fukuhara, M Kuramochi, T Fukami, K Kasahara, N Furuhata, T Nobukuni, T Maruyama, K Isogai, T Sekiya, T Shuin, T Kitamura, RH Reeves, Y Murakami

    JAPANESE JOURNAL OF CANCER RESEARCH　93　(6)　605-609　2002/06

    ISSN： 0910-5050

  15. Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine Peer-reviewed

    K Furushima, K Shimo-Onoda, S Maeda, T Nobukuni, K Ikari, H Koga, S Komiya, T Nakajima, S Harata, Inoue, I

    JOURNAL OF BONE AND MINERAL RESEARCH　17　(1)　128-137　2002/01

    DOI： 10.1359/jbmr.2002.17.1.128 　

    ISSN： 0884-0431

  16. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins Peer-reviewed

    H Fukuhara, M Kuramochi, T Nobukuni, T Fukami, M Saino, T Maruyama, S Nomura, T Sekiya, Y Murakami

    ONCOGENE　20　(38)　5401-5407　2001/08

    DOI： 10.1038/sj.onc.1204696 　

    ISSN： 0950-9232

  17. Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23 Peer-reviewed

    MT Pletcher, T Nobukuni, H Fukuhara, M Kuramochi, T Maruyama, T Sekiya, T Sussan, M Isomura, Y Murakami, RH Reeves

    GENE　273　(2)　181-189　2001/08

    DOI： 10.1016/S0378-1119(01)00592-3 　

    ISSN： 0378-1119

  18. Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1 Peer-reviewed

    S Iwashita, T Itoh, H Takeda, Y Sugimoto, Takahashi, I, T Nobukuni, M Sezaki, T Masui, K Hashimoto

    GENE　268　(1-2)　59-66　2001/05

    DOI： 10.1016/S0378-1119(01)00422-X 　

    ISSN： 0378-1119

  19. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer Peer-reviewed

    M Kuramochi, H Fukuhara, T Nobukuni, T Kanbe, T Maruyama, HP Ghosh, M Pletcher, M Isomura, M Onizuka, T Kitamura, T Sekiya, RH Reeves, Y Murakami

    NATURE GENETICS　27　(4)　427-430　2001/04

    DOI： 10.1038/86934 　

    ISSN： 1061-4036

  20. Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene Peer-reviewed

    M Kanamori, H Kon, T Nobukuni, S Nomura, K Sugano, S Mashiyama, T Kumabe, T Yoshimoto, M Meuth, T Sekiya, Y Murakami

    ONCOGENE　19　(12)　1564-1571　2000/03

    DOI： 10.1038/sj.onc.1203454 　

    ISSN： 0950-9232

  21. Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction Peer-reviewed

    H Kuchiki, M Saino, T Nobukuni, J Yasuda, T Maruyama, T Kayama, Y Murakami, T Sekiya

    INTERNATIONAL JOURNAL OF CANCER　85　(1)　113-116　2000/01

    DOI： 10.1002/(SICI)1097-0215(20000101)85:1<113::AID-IJC20>3.0.CO;2-3 　

    ISSN： 0020-7136

  22. Partial nuclear localization of a bovine phosphoprotein, BCNT, that includes a region derived from a LINE repetitive sequence in Ruminantia Peer-reviewed

    S Iwashita, T Nobukuni, S Tanaka, M Kobayashi, T Iwanaga, HB Tamate, T Masui, Takahashi, I, K Hashimoto

    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　1427　(3)　408-416　1999/05

    ISSN： 0304-4165

    eISSN： 1872-8006

  23. Partial nuclear localization of a bovine phosphoprotein, BCNT, that includes a region derived from a LINE repetitive sequence in Ruminantia. Peer-reviewed

    Iwashita S, Nobukuni T, Tanaka S, Kobayashi M, Iwanaga T, Tamate HB, Masui T, Takahashi I, Hashimoto K

    Biochimica et biophysica acta　1427　(3)　408-416　1999/05

    DOI： 10.1016/S0304-4165(99)00049-5 　

    ISSN： 0006-3002

  24. Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q Peer-reviewed

    Y Murakami, T Nobukuni, K Tamura, T Maruyama, T Sekiya, Y Arai, H Gomyou, A Tanigami, M Ohki, D Cabin, P Frischmeyer, P Hunt, RH Reeves

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　95　(14)　8153-8158　1998/07

    DOI： 10.1073/pnas.95.14.8153 　

    ISSN： 0027-8424

  25. Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomes Peer-reviewed

    Takahashi, I, T Nobukuni, H Ohmori, M Kobayashi, S Tanaka, K Ohshima, N Okada, T Masui, K Hashimoto, S Iwashita

    GENE　211　(2)　387-394　1998/05

    DOI： 10.1016/S0378-1119(98)00136-X 　

    ISSN： 0378-1119

    eISSN： 1879-0038

  26. An Alu-linked repetitive sequence corresponding to 280 amino acids is expressed in a novel bovine protein, but not in its human homologue Peer-reviewed

    T Nobukuni, M Kobayashi, A Omori, S Ichinose, T Iwanaga, Takahashi, I, K Hashimoto, S Hattori, K Kaibuchi, Y Miyata, T Masui, S Iwashita

    JOURNAL OF BIOLOGICAL CHEMISTRY　272　(5)　2801-2807　1997/01

    DOI： 10.1074/jbc.272.5.2801 　

    ISSN： 0021-9258

  27. IDENTIFICATION OF THE PRFC GENE, WHICH ENCODES PEPTIDE-CHAIN-RELEASE FACTOR-3 OF ESCHERICHIA-COLI Peer-reviewed

    O MIKUNI, K ITO, J MOFFAT, K MATSUMURA, K MCCAUGHAN, T NOBUKUNI, W TATE, Y NAKAMURA

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　91　(13)　5798-5802　1994/06

    DOI： 10.1073/pnas.91.13.5798 　

    ISSN： 0027-8424

  28. SYNTHESIS OF UNUSUAL NUCLEOSIDES AND EVALUATIONS OF THEIR BIOLOGICAL PROPERTIES Peer-reviewed

    T WATANABE, S UEKI, T NOBUKUNI, S NISHIYAMA, S YAMAMURA, K KATO, M NAGAI, T TAKITA

    SYMPOSIUM ON NUCLEIC ACIDS TECHNOLOGY　22　(22)　131-132　1990

    ISSN： 0261-3166

Show all ︎Show first 5

Misc. 31

  1. 【ヒト疾患のデータベースとバイオバンク 情報をどう使い、どう活かすか?ゲノム医療をどう実現するか?】 (第2章)疾患データベースとバイオバンク プロジェクトの最前線と利用の実践ガイド 現代的なバイオバンクの発達とその利用法

    信國 宇洋

    実験医学　35　(17)　2958-2962　2017/11

    Publisher: (株)羊土社

    ISSN： 0288-5514

  2. 疾患データベースとバイオバンク【プロジェクトの最前線と利用の実践ガイド】16.現代的なバイオバンクの発達とその利用法

    信國宇洋

    実験医学　35　(17)　2958‐2962　2017/11/01

    ISSN： 0288-5514

  3. 疾患研究における一般住民型大規模バイオバンクの試料管理体制の重要性

    峯岸直子, 工藤久智, 信國宇洋, 寺川貴裕, 石田典子, 西島維知子, 山下理宇

    日本生化学会大会(Web)　89th　ROMBUNNO.3P‐330 (WEB ONLY)-330]　2016/09

    Publisher: (公社)日本生化学会

  4. Plasma proteome analysis for a large-scale population-based cohort study

    Katoh Yasutake, Koshiba Seizo, Igarashi Kazuhiko, Yamamoto Masayuki, Tanabe Osamu, Ebina Masayuki, Shirota Matsuyuki, Motoike Ikuko, Kinoshita Kengo, Kudo Hisaaki, Nobukuni Takahiro, Minegishi Naoko, Saigusa Daisuke

    Abstracts for Annual Meeting of Japanese Proteomics Society　2015　(0)　62-62　2015

    Publisher: Japanese Proteomics Society (Japan Human Proteome Organisation)

    DOI： 10.14889/jhupo.2015.0.62.0 　

  5. 機能的相補法によるがん抑制遺伝子TSLC1の同定と機能解析

    村上 善則, 深見 武史, 増田 万里, 八下田 美佳, 丸山 智子, 磯貝 香奈, 福原 浩, 倉持 雅己, 信國 宇洋

    日本癌学会総会記事　61回　79-79　2002/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  6. Neurotensin and sortilin/neurotensin receptor-3 promote extra-cellular matrix mineralization during osteoblastic differentiation of mesenchymal stem cells.

    S Maeda, T Nobukuni, K Shimo-Onoda, K Hayashi, K Yone, S Komiya, Inoue, I

    JOURNAL OF BONE AND MINERAL RESEARCH　17　S401-S401　2002/09

    ISSN： 0884-0431

  7. 骨関節疾患の遺伝子解析 ソルチリンはヒト間葉系幹細胞の骨芽細胞分化を抑制するリポプロテイン・リパーゼを阻害して石灰化を促進する

    前田 真吾, 信國 宇洋, 下小野田, 一騎, 林 協司, 米 和徳, 小宮 節郎, 井ノ上 逸朗

    日本整形外科学会雑誌　76　(8)　S903-S903　2002/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  8. Osteogenic differentiation of human mesenchymal stem cell could be regulated by beta-catenin pathway.

    S Maeda, K Shimo-Onoda, T Nobukuni, K Hayashi, H Koga, S Matsunaga, K Yone, S Komiya, Inoue, I

    JOURNAL OF BONE AND MINERAL RESEARCH　16　S493-S493　2001/09

    ISSN： 0884-0431

  9. Extensive screening of candidate genes for ossification of the posterior longitudinal ligament of the spine.

    K Furushima, T Tanaka, S Maeda, N Ikari, T Nobukuni, K Shimo-onoda, T Nakajima, S Komiya, S Harata, Inoue, I

    JOURNAL OF BONE AND MINERAL RESEARCH　16　S248-S248　2001/09

    ISSN： 0884-0431

  10. 前立腺癌における新規がん抑制遺伝子TSLC1の不活化と腫瘍形成の抑制

    福原 浩, 倉持 雅己, 信國 宇洋, 深見 武史, 丸山 智子, 関谷 剛男, 村上 善則

    日本癌学会総会記事　60回　107-107　2001/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  11. 新規がん抑制遺伝子TSLC1のプロモーター領域のメチル化による不活化

    倉持 雅己, 福原 浩, 深見 武史, 神戸 貴雅, 信國 宇洋, 丸山 智子, 関谷 剛男, 村上 善則

    日本癌学会総会記事　60回　108-108　2001/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  12. ヒト間葉系幹細胞の骨芽細胞分化とβ-cateninの機能的関連

    前田 真吾, 下小野田, 一騎, 信國 宇洋, 古賀 公明, 林 協司, 松永 俊二, 米 和徳, 小宮 節郎, 井ノ上 逸朗

    日本整形外科学会雑誌　75　(8)　S849-S849　2001/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  13. マイクロアレイによるヒト間葉系幹細胞での骨分化誘導関連遺伝子の包括的発現検討

    下小野田, 一騎, 前田 真吾, 信國 宇洋, 古賀 公明, 林 協司, 松永 俊二, 米 和徳, 小宮 節郎, 井ノ上 逸朗

    日本整形外科学会雑誌　75　(8)　S849-S849　2001/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  14. ヒト間葉系幹細胞の骨芽細胞分化におけるβ-cateninの関与

    前田 真吾, 下小野田, 一騎, 信國 宇洋, 古賀 公明, 林 協司, 松永 俊二, 米 和徳, 小宮 節郎, 井ノ上 逸朗

    日本骨代謝学会雑誌　19　(2)　20-20　2001/07

    Publisher: (一社)日本骨代謝学会

    ISSN： 0910-0067

  15. PP97 新規肺非小細胞がん抑制遺伝子TSLC1の同定と解析

    倉持 雅己, 福原 浩, 信國 宇洋, 神戸 貴雅, 鬼塚 正孝, 村上 善則

    日本外科学会雑誌　102　(0)　248-248　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN： 0301-4894

  16. 新規肺非小細胞がん抑制遺伝子TSLC1の同定と解析

    倉持 雅己, 福原 浩, 信國 宇洋, 神戸 貴雅, 鬼塚 正孝, 村上 善則

    日本外科学会雑誌　102　(臨増)　248-248　2001/03

    Publisher: (一社)日本外科学会

    ISSN： 0301-4894

  17. 前立腺癌における新規がん抑制遺伝子TSLC1の発現低下、並びに腫瘍形成の抑制

    福原 浩, 倉持 雅己, 信國 宇洋, 北村 唯一, 関谷 剛男, 村上 善則

    日本泌尿器科學會雜誌　92　(2)　367-367　2001/02/20

    Publisher: 社団法人日本泌尿器科学会

    DOI： 10.5980/jpnjurol.92.367_4 　

    ISSN： 0021-5287

  18. 前立腺癌における新規がん抑制遺伝子TSLC1の発現低下,ならびに腫瘍形成の抑制

    福原 浩, 倉持 雅己, 信國 宇洋, 北村 唯一, 関谷 剛男, 村上 善則

    日本泌尿器科学会雑誌　92　(2)　367-367　2001/02

    Publisher: (一社)日本泌尿器科学会

    DOI： 10.5980/jpnjurol.92.367_4 　

    ISSN： 0021-5287

  19. Four single-nucleotide polymorphisms in the human BUB1 gene

    T Kanbe, T Nobukuni, H Kawasaki, T Sekiya, Y Murakami

    JOURNAL OF HUMAN GENETICS　46　(3)　150-151　2001

    DOI： 10.1007/s100380170103 　

    ISSN： 1434-5161

  20. 新規肺非小細胞がん抑制遺伝子TSLC1の単離と解析

    村上 善則, 倉持 雅己, 福原 浩, 信國 宇洋, 丸山 智子, 大木 操, 関谷 剛男

    日本癌学会総会記事　59回　222-222　2000/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  21. 第11染色体q23上の新規肺非小細胞がん抑制遺伝子の機能的相補法による同定

    倉持 雅己, 福原 浩, 信國 宇洋, 丸山 智子, 関谷 剛男, 村上 善則

    日本癌学会総会記事　59回　426-426　2000/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  22. Structural and functional evidence for the presence of a tumor suppressor gene in human non-small cell lung cancers on chromosomal region 11q23.2.

    YS Murakami, T Nobukuni, Y Sugiyama, M Kuramochi, H Fukuhara, T Maruyama, T Sekiya, M Pletcher, RH Reeves

    AMERICAN JOURNAL OF HUMAN GENETICS　65　(4)　A312-A312　1999/10

    ISSN： 0002-9297

  23. 第11染色体q23領域におけるヒト肺非小細胞がん抑制遺伝子の探索(II)

    福原 浩, 信國 宇洋, 倉持 雅己, 丸山 智子, 関谷 剛男, 村上 善則

    日本癌学会総会記事　58回　553-553　1999/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  24. 第11染色体q23領域におけるヒト肺非小細胞がん抑制遺伝子の探索(I)

    倉持 雅己, 信國 宇洋, 福原 浩, 丸山 智子, 関谷 剛男, 村上 善則

    日本癌学会総会記事　58回　553-553　1999/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  25. 遺伝的相補実験に基づく肺非小細胞がん抑制遺伝子の単離の試み

    村上 善則, 信國 宇洋, 田村 研治, 丸山 智子, 新井 康仁, 五明 広樹, 谷上 信, 大木 操, Reeves Roger H, 関谷 剛男

    日本癌学会総会記事　57回　48-48　1998/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  26. ヒト神経膠腫におけるPTEN遺伝子変異,並びにマイクロサテライト不安定性の解析

    昆 博之, 信國 宇洋, 園田 順彦, 野村 幸男, 菅野 康吉, 隈部 俊宏, 吉本 高志, 関谷 剛男, 村上 善則

    日本癌学会総会記事　57回　455-455　1998/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  27. Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q

    Yoshinori Murakami, Takahiro Nobukuni, Kenji Tamura, Tomoko Maruyama, Takao Sekiya, Yasuhito Arai, Hiroki Gomyou, Akira Tanigami, Misao Ohki, Deborah Cabin, Pam Frischmeyer, Piper Hunt, Roger H. Reeves

    Proceedings of the National Academy of Sciences of the United States of America　95　(14)　8153-8158　1998/07/07

    DOI： 10.1073/pnas.95.14.8153 　

    ISSN： 0027-8424

  28. 酵母人工染色体(YAC)クローンの断片化,ならびに挿入ヒトDNA断片のがん細胞への移入によるヒト肺非小細胞がん抑制遺伝子単離の試み

    信國 宇洋

    日本癌学会総会記事　56回　265-265　1997/08

    Publisher: 日本癌学会

    ISSN： 0546-0476

  29. A/u関連反復配列様領域をORF内に含む新規蛋白質

    信國 宇洋, 小林 まり子, 大森 彬, 吉田 幸代, 岩永 敏彦, 橋本 雄之, 服部 成介, 貝淵 弘三, 増井 徹, 中村 義一, 岩下 新太郎

    日本分子生物学会年会プログラム・講演要旨集　19　578-578　1996/08/01

  30. Alu関連反復配列様領域をORF内に含む新規蛋白質

    信國 宇洋

    生化学　68　(7)　1090-1090　1996/07

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

  31. RasGTPase活性化タンパク質ファミリー

    小林 まり子, 信國 宇洋, 岩下 新太郎

    生体の科学　46　(5)　584-586　1995/10

    Publisher: (公財)金原一郎記念医学医療振興財団

    DOI： 10.11477/mf.2425901009 　

    ISSN： 0370-9531

Show all ︎Show first 5

Research Projects 1

  1. 腸内・腫瘍内細菌叢による膠芽腫治療の新機軸

    金森 政之, 山下 理宇, 齋藤 さかえ, 信國 宇洋, 下田 由輝

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31