Details of the Researcher

PHOTO

Noriyuki Iwama
Section
Tohoku University Hospital
Job title
Associate Professor
Degree

  • 博士（医学）（東北大学）

e-Rad No.
90755597
Profile
日本産科婦人科学会認定専門医・指導医
日本周産期・新生児医学会 周産期専門医

Research History 17

  • 2021/04 - 2024/03
    東北大学大学院医学系研究科　女性ヘルスケア医科学共同研究講座　講師

  • 2021/04 - 2024/03
    東北大学病院　産婦人科　講師

  • 2018/07 - 2021/03
    東北大学病院　周産母子センター　助教

  • 2016/04 - 2018/06
    大崎市民病院　産婦人科　副科長

  • 2015/12 - 2016/03
    Tohoku University　Graduate School of Medicine

  • 2015/05 - 2015/11
    東北大学病院　産科　特任助手

  • 2015/04 - 2015/04
    東北大学病院　産科　医員

  • 2011/04 - 2013/03
    東北大学病院　産科　医員（大学院生）

  • 2010/10 - 2011/03
    東北大学病院　産科　医員

  • 2010/05 - 2010/09
    東北公済病院　産婦人科　医師

  • 2009/04 - 2010/04
    石巻赤十字病院　産婦人科　医師

  • 2008/12 - 2009/03
    東北大学病院　産科　医員

  • 2008/05 - 2008/11
    仙台赤十字病院　産婦人科　医師

  • 2007/10 - 2008/04
    仙台市立病院　産婦人科　医師

  • 2007/04 - 2007/09
    東北大学病院　産科　医員

  • 2005/04 - 2007/03
    National Hospital Organization

  • 2024/04 -
    Tohoku University Hospital　Perinatal Care Center

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Education 2

  • Tohoku University　Graduate School of Medicine　Department of Medical Sciences

    2011/04 - 2015/03

  • Hirosaki University　School of Medicine　Medicine

    1999/04 - 2005/03

Committee Memberships 2

  • 日本糖尿病・妊娠学会　評議員

    2022/10 - Present

  • 日本周産期・新生児医学会　評議員

    2022/07 - 2024/06

Awards 3

  1. 2024年度 医学系研究科 教育貢献賞

    2025/03　東北大学医学部

  2. 大森賞

    2020/08　日本糖尿病・妊娠学会

  3. The Seventh Hypertension Research Award of Excellence

    2016/10

Papers 157

  1. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children

    Chikana Kawaguchi, Mami Ishikuro, Ryota Saito, Keiko Murakami, Aoi Noda, Genki Shinoda, Misato Aizawa, Hisashi Ohseto, Noriyuki Iwama, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

    The Journal of Clinical Endocrinology & Metabolism　2025/09/16

    DOI： 10.1210/clinem/dgae825 　

  2. Association of Quinolone Exposure in the First-Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. International-journal

    Kei Morishita, Taku Obara, Tomofumi Ishikawa, Ryo Obara, Takamasa Sakai, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroshi Kawame, Nariyasu Mano, Shinichi Kuriyama

    Pharmacoepidemiology and drug safety　34　(9)　e70190　2025/09

    DOI： 10.1002/pds.70190 　

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    PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with quinolone exposure during the first trimester of pregnancy using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to November 2019. The dates of pregnancy onset and delivery were estimated using the developed algorithm. MCMs were defined according to the International Classification of Diseases, 10th revision codes. The risk of MCM associated with first-trimester quinolone prescriptions was evaluated in women with infectious diseases diagnosed during the first trimester of pregnancy. We evaluated the overall risk of MCMs in infants, and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by comparing women with first-trimester prescriptions of quinolones with those without antibiotic prescriptions, adjusting for covariates with propensity score overlap weights. RESULTS: The prevalence of first-trimester infectious diseases was 51.6% (47 121/91390). Among 47 121 women diagnosed with infectious diseases, 1 320 were prescribed quinolones during their first trimester of pregnancy. The overall prevalence of MCMs was 6.0% (2282/37766) in women unexposed to antibiotics and 5.9% (78/1320) in those exposed to quinolones. The first-trimester prescription of quinolone was not significantly associated with the overall MCM prevalence when overlap-weighted ORs (wOR) were calculated using propensity score overlap weights for covariates (wOR 0.904, 95% CIs 0.684-1.196). CONCLUSIONS: Prescription of quinolones in the first-trimester of pregnancy was not associated with an increased risk of MCMs in infants. Our findings may support clinical decision-making when considering quinolone use during the first-trimester of pregnancy.

  3. MR Imaging of Umbilical Cord Variations, Abnormalities, and Associated Placental Findings.

    Sakiko Kageyama, Tomomi Sato, Noriyuki Iwama, Hirotaka Hamada, Masatoshi Saito, Kei Takase

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine　2025/07/31

    DOI： 10.2463/mrms.rev.2025-0036 　

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    The umbilical cord and placenta, classified as fetal appendages, play a crucial role in fetal growth and survival. While ultrasonography remains the primary modality for evaluation, MRI provides a more objective and comprehensive assessment, particularly for the placenta and fetus. Although MRI assessment of the umbilical cord is still emerging and not yet widely adopted by radiologists, MRI has the potential to support and complement ultrasound findings, thereby contributing to safer perinatal management. This review summarizes key MRI findings related to the umbilical cord and associated placental abnormalities. In cases where MRI reports are currently unavailable, ultrasound findings are included to supplement the discussion and to support inferences of potential MRI findings, encouraging future diagnostic applications. Initially, we describe the normal morphology and physiological changes of the umbilical cord and placenta, recommended MRI sequences, and normal imaging findings. Placental abnormalities associated with umbilical cord anomalies, including morphological and positional abnormalities, are reviewed. Variations in umbilical cord insertion, particularly marginal and velamentous insertion, as well as vasa previa, are also discussed. Abnormalities related to umbilical cord position and morphology, such as hypercoiling and hypocoiling, cord knots, nuchal cords, and cord presentation, are examined. Additionally, vascular abnormalities, including single umbilical artery, fused umbilical artery, supernumerary vessels, varices, and aneurysms, are explored along with their underlying mechanisms. Finally, umbilical cord cysts and umbilical cord ulcers are addressed. Advancements in imaging technology, particularly Doppler ultrasonography, have significantly improved the detection and management of umbilical cord and placental abnormalities. Understanding these abnormalities in prenatal MRI evaluation is crucial for improving diagnostic accuracy and optimizing perinatal care. MRI may prove to be a useful adjunct when ultrasound findings are inconclusive or when additional anatomical and functional information is needed. However, further studies are needed to clarify MRI's clinical utility.

  4. Analysis of the Japanese gestational diabetes mellitus diagnostic strategy during the coronavirus disease 2019 pandemic using DREAMBee study data

    Yoshifumi Kasuga, Kei Miyakoshi, Maki Yokoyama, Noriyuki Iwama, Raishi Ichikawa, Hiroshi Yamashita, Ichiro Yasuhi, Asami Ito, Hirohito Sone, Atsuko Abiko, Shinichi Harashima, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Iimura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama

    Journal of Diabetes Investigation　2025/06

    DOI： 10.1111/jdi.70031 　

  5. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. International-journal

    Hisashi Ohseto, Mami Ishikuro, Geng Chen, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama

    Scientific reports　15　(1)　18924-18924　2025/05/29

    DOI： 10.1038/s41598-025-03652-x 　

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    Adverse pregnancy outcomes (APOs) affect approximately 20% pregnant women, and their incidence is increasing. The aim of this study was to investigate the effect of cardiovascular health (CVH) during pregnancy on APOs. We analyzed data from 14,930 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. CVH status during pregnancy was assessed using the eight components of Life's Essential 8. APOs were defined as composite outcomes encompassing preeclampsia, gestational diabetes mellitus, preterm birth, and small for gestational age. The numbers of participants with high, moderate, and low CVH status were 2891 (19.4%), 11,498 (77.0%), and 541 (3.6%), respectively. Poisson regression analyses with robust error variance, which adjusted for maternal age at conception, alcohol consumption, conception via in vitro fertilization, parity, psychological distress, social isolation, and household income, showed a positive association between moderate and low CVH levels and APOs (risk ratio and 95% confidence interval 1.15 [1.03-1.28] and 2.14 [1.78-2.58], respectively). Among pregnant women with low CVH, those who reported social isolation had a higher prevalence of APOs than did those without social isolation (36.4% vs. 27.4%). This difference was attenuated for pregnant women with high CVH status (13.6% vs. 13.1%). In conclusion, CVH status may be useful for assessing the risk of APOs. Socially isolated pregnant women are more vulnerable to the effects of low CVH status.

  6. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. International-journal

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Akira Narita, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

    Scientific reports　15　(1)　13743-13743　2025/04/21

    DOI： 10.1038/s41598-025-97291-x 　

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    Genomic information from pregnant women and the paternal parent of their fetuses may provide effective biomarkers for preeclampsia (PE). This study investigated the association of parental polygenic risk scores (PRSs) for blood pressure (BP) and PE with PE onset and evaluated predictive performances of PRSs using clinical predictive variables. In the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, 19,836 participants were genotyped using either Affymetrix Axiom Japonica Array v2 (further divided into two cohorts-the PRS training cohort and the internal-validation cohort-at a ratio of 1:2) or Japonica Array NEO (external-validation cohort). PRSs were calculated for systolic BP (SBP), diastolic BP (DBP), and PE and hyperparameters for PRS calculation were optimized in the training cohort. PE onset was associated with maternal SBP-, DBP-, and PE-PRSs and paternal SBP- and DBP-PRSs only in the external-validation cohort. Meta-analysis revealed overall associations with maternal PRSs but highlighted significant heterogeneity between cohorts. Maternal DBP-PRS calculated using "LDpred2" presented the most improvement in prediction models and provided additional predictive information on clinical predictive variables. Paternal DBP-PRS improved prediction models in the internal-validation cohort. In conclusion, Parental PRS, along with clinical predictive variables, is potentially useful for predicting PE.

  7. Impact of maternal overweight/obesity and high fasting plasma glucose on adverse perinatal outcomes in early gestational diabetes mellitus

    Noriyuki Iwama, Maki Yokoyama, Hiroshi Yamashita, Kei Miyakoshi, Ichiro Yasuhi, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Iimura, Waguri Masako, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama

    Journal of Diabetes Investigation　2025/04

    DOI： 10.1111/jdi.14411 　

  8. Association between paternal physique and obesity in children at the age of 3 years: the Japan Environment and Children's Study. International-journal

    Yui Inoue, Maki Yokoyama, Shota Inoue, Matome Imai, Hiroshi Onji, Akiko Yano, Yuka Uchikura, Yuko Matsubara, Keiichi Matsubara, Hirotaka Hamada, Hasumi Tomita, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito, Takashi Sugiyama

    Journal of developmental origins of health and disease　16　e17　2025/03/21

    DOI： 10.1017/S2040174424000473 　

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    Obesity during development has been reported to be a determinant factor in the future development of non-communicable diseases (NCDs). Parental obesity is suggested to be a predictor of children's obesity, and it is important to consider parental factors to prevent NCDs in the progeny. Previously, we showed that paternal height had a stronger association with infant birth weight than paternal body mass index (BMI) in the Japanese population. However, only a few studies have examined the association between paternal physique and postnatal obesity. This study aimed to investigate the association between parental physique and obesity in children at the age of 3. This study used fixed data on 33,291 parent-child pairs from the Japan Environment and Children's Study, an ongoing national birth cohort study. The association between paternal physique (BMI and height) and children's obesity at the age of 3 was examined using multivariate logistic regression analysis. The higher the paternal BMI quartiles, the higher the odds ratio for obesity in male and female children at 3 years of age (P < 0.0001). However, paternal height quartiles were not associated with male or female obesity. These results differ from the association between paternal physique and infant birth weight, and it is possible that prenatal epigenetic and environmental factors of paternal origin were responsible for the differences between these two studies. The association between paternal BMI and obesity in children at the age of 3 suggests that paternal factors may be involved in the development of NCDs in future progeny.

  9. Impact of maternal smoking and secondhand smoke exposure during singleton pregnancy on placental abruption: analysis of a prospective cohort study (the Japan Environment and Children's Study). International-journal

    Hikaru Karumai-Mori, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    BMJ open　15　(3)　e089499　2025/03/04

    DOI： 10.1136/bmjopen-2024-089499 　

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    OBJECTIVES: This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking and secondhand smoke (SHS) exposure during pregnancy with placental abruption. DESIGN: Prospective cohort study. SETTING: 15 regional centres in Japan. PARTICIPANTS: Pregnant women registered between January 2011 and March 2014 from the Japan Environment and Children's Study. OUTCOME MEASURES: Data were transcribed from medical records and two self-administered questionnaires. The outcome measure was the incidence of placental abruption. Maternal smoking exposure during pregnancy was categorised based on the number of cigarettes smoked (≤10 or ≥11 cigarettes per day). SHS exposure during pregnancy was evaluated by frequency and duration (almost never or never, 1-3 days/week and/or <1 hour/day and 4-7 days/week and ≥1 hour/day). A modified Poisson regression model, adjusted for known placental abruption risk factors, calculated the risk ratio (RR) and PAF for placental abruption with a 95% Cl. RESULTS: Of the 81 974 eligible pregnant women, pregnant women smoking ≥11 cigarettes/day during pregnancy had a significantly higher risk of placental abruption. The adjusted RR (aRR) was 2.21 (95% CI 1.21 to 4.06), and the adjusted PAF (aPAF) was 1.90% (95% CI 0.09 to 3.71%). Pregnant women among never-smokers with SHS exposure of 4-7 days/week and ≥1 hour/day had a significantly higher risk (aRR: 2.34, 95% CI 1.29 to 4.28), and the aPAF was 1.89% (95% CI -0.05 to 3.83). Additionally, pregnant women among those who smoked during pregnancy with similar SHS exposure had a significantly higher risk (aRR: 2.21, 95% CI 1.30 to 3.76), with the aPAF of 2.29% (95% CI 0.11 to 4.48). CONCLUSIONS: Maternal smoking and SHS exposure during pregnancy significantly contribute to the risk of placental abruption in Japan. Therefore, preventive interventions and measures to reduce exposure are required to prevent placental abruption.

  10. Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan

    Maki Yokoyama, Kei Miyakoshi, Noriyuki Iwama, Hiroshi Yamashita, Ichiro Yasuhi, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Imura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama

    Journal of Diabetes Investigation　2025/03

    DOI： 10.1111/jdi.14368 　

  11. Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    Journal of diabetes investigation　2025/01/11

    DOI： 10.1111/jdi.14400 　

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    AIMS: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). METHODS: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years. RESULTS: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively. CONCLUSIONS: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.

  12. Pregnancy and Postpartum Trends in Self‐Measured Blood Pressure and Derived Indices: The BOSHI Study

    Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    The Journal of Clinical Hypertension　2025/01

    DOI： 10.1111/jch.14949 　

  13. Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama

    Journal of epidemiology　2024/12/21

    DOI： 10.2188/jea.JE20240293 　

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    BACKGROUND: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations, and conducted a self-administered food frequency questionnaire with the response option "constitutionally unable to eat or drink it" for individual food items (TMM-FFQ) for pregnant women. This study evaluated the validity of the TMM-FFQ among pregnant women. METHODS: Participants comprised 122 pregnant women aged ≥20 years residing in Miyagi Prefecture who completed weighed food records (WFRs) for 3 days as reference intake and the TMM-FFQ during mid-pregnancy. Correlations between nutrient or food group intakes based on the WFR and the TMM-FFQ were calculated using Spearman's rank correlation coefficients (CCs), adjusting for energy intake and correcting for random within-individual variation of WFR. Cross-classification was also conducted according to quintiles using the WFR and TMM-FFQ data. RESULTS: The percentages of participants who chose the "constitutionally unable to eat or drink it" option were >3% for seven food and drink items. CCs were >0.30 for 31 nutrients; the median across energy and 44 nutrients was 0.41. CCs were >0.30 for 14 food groups; the median across 20 food groups was 0.35. The median percentages of cross-classification into exact plus adjacent quintiles and extreme quintiles were 63.1% and 3.3% for energy and nutrients and 61.9% and 4.1% for food groups, respectively. CONCLUSIONS: The validity of the TMM-FFQ compared with the WFR was reasonable for certain nutrients and food groups among pregnant women in the TMM BirThree Cohort Study.

  14. Association of Parity with Type 2 Diabetes Mellitus in Japan. International-journal

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    Reproductive sciences (Thousand Oaks, Calif.)　2024/12/11

    DOI： 10.1007/s43032-024-01752-z 　

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    This study investigates the association between parity and type 2 diabetes mellitus (T2DM) in Japanese women, considering the clinical history of gestational diabetes mellitus (GDM) and menopausal status, which are known risk factors for T2DM. Overall, 30,116 Japanese women (6,588 premenopausal and 23,528 postmenopausal) were included in this cross-sectional study. They were divided into two groups according to menopausal status (premenopausal and postmenopausal women), and the association between parity and T2DM was evaluated using a multiple logistic regression model with possible confounders, including a clinical history of GDM. The association between parity and T2DM was not statistically significant in premenopausal women. In contrast, a linear graded association between parity and T2DM was found in postmenopausal women. Furthermore, the association between parity and T2DM in postmenopausal women was attenuated after adjusting for body weight gain after the age of 20 years. A clinical history of GDM was significantly associated with a high risk for T2DM, regardless of adjustment for body weight gain after the age of 20 years in both premenopausal and postmenopausal women. Parity is associated with an increased risk of T2DM in postmenopausal women but not in premenopausal women. Maintaining appropriate body weight would be beneficial in attenuating the risk of T2DM in postmenopausal women. A clinical history of GDM is a risk factor for T2DM in both pre- and postmenopausal women; therefore, women with a clinical history of GDM require continuous medical care to survey for T2DM.

  15. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

    PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

    DOI： 10.1002/pcn5.70025 　

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    AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.

  16. 血管型Ehlers-Danlos症候群合併妊娠の周産期管理 : 症例報告と文献的レビュー

    54　(11)　1562-1565　2024/11/10

    Publisher:

    DOI： 10.24479/peri.0000001795 　

    ISSN： 0386-9881

  17. Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Mami Ishikuro, Taku Obara, Mayu Hasegawa, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Noriyuki Iwama, Masahiro Kikuya, Junichi Sugawara, Tatsuhiko Azegami, Takashin Nakayama, Asako Mito, Naoko Arata, Hirohito Metoki, Takeshi Kanda, Shinichi Kuriyama

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/10/11

    DOI： 10.1038/s41440-024-01936-9 　

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    Hypertensive disorders of pregnancy can cause hypertension in the future. Understanding how the blood pressure values of women with and without hypertensive disorders of pregnancy differ will facilitate follow-up blood pressure monitoring in clinical settings. This study investigated the association between hypertensive disorders of pregnancy and subsequent high blood pressure and hypertension. This study used Japanese data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Follow-up systolic and diastolic blood pressures in normotensive women during pregnancy and those with hypertensive disorders of pregnancy were estimated using analysis of covariance adjusted for women with low birthweight, history of gestational diabetes mellitus, age, body mass index, pulse rate, smoking and drinking at the follow-up assessment, paternal hypertension history, and maternal hypertension or hypertensive disorders of pregnancy history. Finally, we performed a multiple logistic regression analysis. In total, 7343 women were included in the analysis. Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared with normotensive women. Hypertensive disorders of pregnancy in the most recent pregnancy in different subgroups, such as nulliparous women, multiparous women without a history of hypertensive disorders of pregnancy, and multiparous women with a history of hypertensive disorders of pregnancy, were associated with an increased risk of subsequent hypertension. Women's birthweight was also weakly associated with hypertension. Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure and hypertension approximately three years postpartum. In addition, women's birthweights may have a weak relationship with increasing blood pressure.

  18. Is early pregnancy hemoglobin A1c useful to predict gestational diabetes mellitus diagnosed during mid pregnancy? International-journal

    Sayuri Nakanishi, Shigeru Aoki, Noriyuki Iwama, Ichiro Yasuhi, Takashi Sugiyama, Kei Miyakoshi

    The journal of obstetrics and gynaecology research　2024/10/10

    DOI： 10.1111/jog.16108 　

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    AIMS: To verify whether hemoglobin A1c (HbA1c) levels in early pregnancy can predict the diagnosis of gestational diabetes mellitus (GDM) in mid-pregnancy. MATERIALS AND METHODS: This was a retrospective cohort study of 2008 pregnant women who delivered singletons at the Yokohama City university Medical Center. Concomitant or history of diabetes mellitus and overt diabetes in pregnancy were excluded. Pregnant women at high risk for GDM underwent a one-step 75-g oral glucose tolerance test (OGTT) during mid-pregnancy. For other pregnant women, GDM was diagnosed by a two-step 75-g oral glucose tolerance test (OGTT) when the 50-g glucose challenge test result in mid-pregnancy was ≥140 mg/dL. The thresholds for 75-g OGTT followed those of the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria (92-180-153 mg/dL). The relationship between HbA1c level measured at <20 weeks of gestation and GDM diagnosis at mid pregnancy was assessed using a receiver operating characteristic curve (ROC); area under the curve (AUC) and optimal cutoff value of HbA1c, predictive of GDM were calculated. RESULTS: The median HbA1c level at <20 weeks of gestation was 5.3%, and 8.5% of women were diagnosed with GDM. In the ROC curve of the GDM diagnosis rate by HbA1c level, AUC was 0.706, and the optimal cutoff value was 5.4%, with a sensitivity of 0.6176, specificity of 0.6834, positive predictive value of 15.4%, and negative predictive value of 95.1%. CONCLUSIONS: Although HbA1c at less than 20 weeks of gestation is acceptable discrimination as a diagnostic tool of GDM in mid-pregnancy, it is not clinically useful to predict GDM in mid-pregnancy.

  19. 妊娠糖尿病の診断時期と周産期予後および産後耐糖能異常との関連についての検討

    横山 真紀, 岩間 憲之, 宮越 敬, 山下 洋, 安日 一郎, 川崎 麻紀, 荒田 尚子, 佐藤 志織, 飯村 祐子, 和栗 雅子, 川口 晴菜, 正岡 直樹, 中島 義之, 平松 祐司, 杉山 隆

    糖尿病と妊娠　24　(3)　S-107　2024/10

    Publisher: (一社)日本糖尿病・妊娠学会

    ISSN： 1347-9172

  20. 母体出生体重と前半期および後半期妊娠糖尿病との関連

    田上 和磨, 岩間 憲之, 杉山 隆, 齋藤 昌利

    糖尿病と妊娠　24　(3)　S-130　2024/10

    Publisher: (一社)日本糖尿病・妊娠学会

    ISSN： 1347-9172

  21. Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. International-journal

    Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    Acta psychiatrica Scandinavica　2024/09/05

    DOI： 10.1111/acps.13755 　

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    OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.

  22. 分娩後に劇症型A群レンサ球菌感染症による血栓性微小血管症(TMA)を合併した一例

    金銅 妃奈子, 岡本 好司, 秋保 真穂, 濱田 裕貴, 只川 まり, 岩間 憲之, 齋藤 昌利, 田中 哲洋, 宮崎 真理子

    日本腎臓学会誌　66　(6-E)　883-883　2024/09

    Publisher: (一社)日本腎臓学会

    ISSN： 0385-2385

    eISSN： 1884-0728

  23. 二次性血栓性微小血管症を合併した産褥劇症型溶血性レンサ球菌感染症の一例

    鈴木 由佳, 柳田 純子, 佐藤 珠希, 田上 和磨, 濱田 裕貴, 只川 真理, 岩間 憲之, 入間田 大介, 宮崎 真理子, 齋藤 昌利

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　71回　38-38　2024/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  24. 分娩後異常出血にて救急搬送され急性妊娠脂肪肝と診断した一例

    両國 啓, 富田 芙弥, 木村 翔太, 鶴田 光将, 田上 和磨, 柳田 純子, 濱田 裕貴, 只川 真理, 岩間 憲之, 齋藤 昌利

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　71回　56-56　2024/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  25. Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study.

    Seiya Izumi, Noriyuki Iwama, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Michihiro Satoh, Takahisa Murakami, Masatoshi Saito, Takayoshi Ohkubo, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Endocrine journal　2024/07/26

    DOI： 10.1507/endocrj.EJ23-0568 　

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    This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87-125 mg/dL) and HbA1c (5.2-6.3% [33-45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002-1.775) for Q4 of FPG and 1.405 (95% CI: 1.051-1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000-1.496) and 1.392 (95% CI: 1.122-1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels.

  26. Current status of screening and management of gestational diabetes in early pregnancy: a questionnaire survey in Japan.

    Maki Yokoyama, Kei Miyakoshi, Sayuri Nakanishi, Noriyuki Iwama, Shigeru Aoki, Ichiro Yasuhi, Takashi Sugiyama

    Diabetology international　15　(3)　627-631　2024/07

    DOI： 10.1007/s13340-024-00700-1 　

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    Our aim is to investigate the obstetric practices in Japan regarding the screening and management of gestational diabetes mellitus (GDM) diagnosed before 20 weeks of gestation (early-GDM). A web-based questionnaire survey was administered to 991 teaching hospitals between November 2021 and February 2022, and 602 responses were received (a response rate of 61%). Screening tests for all pregnant women in the first trimester were conducted in 553 (92%) hospitals, and nearly all of these hospitals (535/553 [97%]) adhered to an individual protocol, predominantly relying on random plasma glucose measurements (488/535 [91%]). A quarter (139 [26%]) implemented a risk profile assessment for GDM screening, taking into account factors such as previous gestational diabetes, prior macrosomia, and family history of diabetes. A small number (23 [4%]) targeted only women at high risk of GDM using the risk profile assessment. The majority of hospitals (501 [94%]) employed a 75 g oral glucose tolerance test as a diagnostic measure, and glycemic control for early-GDM was established in most hospitals (429 [80%]). Of the 535 hospitals that maintained an individual management protocol, 356 [67%] facilitated dietary management, self-monitoring of blood glucose, and insulin administration if needed to meet glycemic targets. Our survey revealed a widespread adoption of universal screening and subsequent treatment for early-GDM in Japan.

  27. 妊娠39週,腹痛から母体死亡に至った血管型エーラス・ダンロス症候群疑いの一例

    餅井 規吉, 只川 真理, 後藤 なつみ, 泉 聖也, 安藤 宏輔, 佐藤 壮樹, 齊藤 裕也, 高橋 司, 齋藤 翔子, 富田 芙弥, 濱田 裕貴, 岩間 憲之, 佐藤 多代, 鈴木 久也, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P307-P307　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  28. 宮城県における未受診妊産婦の現状

    星合 哲郎, 富田 芙弥, 岩間 憲之, 濱田 裕貴, 工藤 さくら, 谷川原 真吾, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P312-P312　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  29. 妊婦自身の出生体重と早発型および遅発型妊娠高血圧症候群との関連

    田上 和磨, 岩間 憲之, 濱田 裕貴, 富田 芙弥, 工藤 理永, 熊谷 奈津美, 佐藤 直人, 泉 聖也, 目時 弘仁, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P189-P189　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  30. 産科DICにおける線溶系マーカーと血液製剤投与量に関する後ろ向きコホート研究

    邑本 美沙希, 濱田 裕貴, 森 亘平, 後藤 なつみ, 泉 聖也, 餅井 規吉, 高橋 司, 齋藤 翔子, 富田 芙弥, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P223-P223　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  31. 二次性子宮頸管無力症に対するTACの有用性について

    安藤 宏輔, 濱田 裕貴, 森 亘平, 後藤 なつみ, 泉 聖也, 田上 和磨, 餅井 規吉, 齊藤 裕也, 高橋 司, 齋藤 翔子, 富田 芙弥, 赤石 美穂, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P227-P227　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  32. 妊娠週数が周産期救急搬送コーディネート時間に与える影響

    工藤 さくら, 富田 芙弥, 後藤 なつみ, 泉 聖也, 安藤 宏輔, 田上 和磨, 齊藤 裕也, 高橋 司, 齋藤 翔子, 赤石 美穂, 濱田 裕貴, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P230-P230　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  33. 母体血清中sFlt-1/PIGF比と超音波断層法による胎児循環パラメーターに関する後ろ向きコホート研究

    森 亘平, 濱田 裕貴, 後藤 なつみ, 泉 聖也, 安藤 宏輔, 齊藤 裕也, 餅井 規吉, 高橋 司, 齋藤 翔子, 富田 芙弥, 赤石 美穂, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P237-P237　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  34. アンジオテンシンII受容体拮抗薬投与により羊水過少・新生児腎機能障害・乳児期高血圧を発症した1例

    後藤 なつみ, 富田 芙弥, 小原 拓, 泉 聖也, 田上 和磨, 餅井 規吉, 齊藤 裕也, 高橋 司, 齋藤 翔子, 赤石 美穂, 濱田 裕貴, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P240-P240　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  35. 両親の出生体重は児の出生体重と関連している 子どもの健康と環境に関する全国調査(エコチル調査)より

    富田 芙弥, 岩間 憲之, 濱田 裕貴, 工藤 理永, 田上 和磨, 熊谷 奈津美, 泉 聖也, 星合 哲郎, 目時 弘仁, 菅原 準一, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P299-P299　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  36. 妊娠39週,腹痛から母体死亡に至った血管型エーラス・ダンロス症候群疑いの一例

    餅井 規吉, 只川 真理, 後藤 なつみ, 泉 聖也, 安藤 宏輔, 佐藤 壮樹, 齊藤 裕也, 高橋 司, 齋藤 翔子, 富田 芙弥, 濱田 裕貴, 岩間 憲之, 佐藤 多代, 鈴木 久也, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P307-P307　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  37. Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index. International-journal

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    BMC nephrology　25　(1)　166-166　2024/05/17

    DOI： 10.1186/s12882-024-03604-z 　

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    BACKGROUND: Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan. Therefore, this study aimed to examine the relationship between parity and the prevalence of CKD in a Japanese population, considering the clinical history of hypertensive disorders of pregnancy (HDP) and current body mass index (BMI) based on menopausal status. METHODS: This cross-sectional study included 26,945 Japanese multiparous women (5,006 premenopausal and 21,939 postmenopausal women) and 3,247 nulliparous women (1,599 premenopausal and 1,648 postmenopausal women). Participants were divided into two groups based on their menopausal status (premenopausal and postmenopausal women). The relationship between parity and the prevalence of CKD was evaluated using a multiple logistic regression model adjusted for several covariates, including a clinical history of HDP and current BMI. RESULTS: The relationship between parity and the prevalence of CKD was not statistically significant in either premenopausal or postmenopausal multiparous women. A clinical history of HDP was significantly associated with an increased risk of CKD in premenopausal and postmenopausal multiparous women. However, the relationship between a clinical history of HDP and CKD in premenopausal women was weakened after adjusting for current BMI. Furthermore, the current BMI was significantly associated with an increased risk of CKD in both premenopausal and postmenopausal women. CONCLUSIONS: Parity is not significantly associated with the prevalence of CKD in premenopausal and postmenopausal multiparous women. A clinical history of HDP is a risk factor for CKD in both premenopausal and postmenopausal women. Current BMI is also associated with an increased risk of CKD in premenopausal and postmenopausal women. Therefore, continuous surveillance and preventive measures against CKD should be provided to women with a clinical history of HDP. In addition, maintaining an appropriate body weight is beneficial in reducing the risk of CKD.

  38. Risk Assessment of Critical Obstetric Bleeding With Low-Molecular-Weight Heparin. International-journal

    Miho Akaishi, Kunio Tarasawa, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Tetsuya Akaishi, Kiyohide Fushimi, Kenji Fujimori, Nobuo Yaegashi, Masatoshi Saito

    Cureus　16　(5)　e59933　2024/05

    DOI： 10.7759/cureus.59933 　

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    BACKGROUND: Use of unfractionated heparin (UFH) during the peripartum period is considered to be a higher risk of critical obstetric bleeding compared to low-molecular-weight heparin (LMWH). However, the evidence for the safety of using LMWH during the peripartum period is currently lacking. METHODS: This study retrospectively investigated a nationwide medical database to clarify the safety of using LMWH during childbirth. The Japanese Nationwide Diagnosis Procedure Combination database was retrospectively reviewed, and data from women with childbirth between 2018 and 2022 were collected. RESULTS: Among the overall 354,299 women with childbirth, 3,099 were with obstetric disseminated intravascular coagulation (DIC), 484 were with critical obstetric bleeding requiring massive red blood cell (RBC) transfusion ≥4,000 cc, and 38 were with maternal death. Among the overall women, each of the anticoagulants other than LMWH was associated with critical obstetrical bleeding with an adjusted odds ratio (aOR) greater than 1.0, while LMWH was not associated with critical obstetrical bleeding (aOR, 0.54 (95% confidence interval, 0.11-2.71)). This finding did not change in subgroup analyses among those with Cesarean section. Furthermore, UFH was associated with critical bleeding among the 3,099 women with obstetrical DIC (aOR, 3.91 (2.83-5.46)), while LMWH was not (aOR, 0.26 (0.03-1.37)). CONCLUSION: The use of UFH was significantly associated with an increased critical obstetric hemorrhage requiring massive RBC transfusion or total hysterectomy. Meanwhile, the use of LMWH was not associated with increased critical obstetric bleeding. LMWH would be safer than UFH to be used for women during childbirth.

  39. 妊娠糖尿病について 妊娠糖尿病診断基準の概要

    岩間 憲之, 齋藤 昌利, 杉山 隆

    日本周産期・新生児医学会雑誌　59　(4)　648-650　2024/04

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  40. Use of the Japanese gestational diabetes mellitus diagnostic strategy during the COVID-19 pandemic in Japan: A questionnaire survey. International-journal

    Yoshifumi Kasuga, Kei Miyakoshi, Maki Yokoyama, Sayuri Nakanishi, Noriyuki Iwama, Raishi Ichikawa, Atsuko Abiko, Shinichi Harashima, Takashi Sugiyama

    The journal of obstetrics and gynaecology research　2024/03/24

    DOI： 10.1111/jog.15929 　

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    AIM: Some concerns exist that diagnosis of gestational diabetes mellitus (GDM) may be missed when the simplified diagnostic criteria of the Japanese Society of Diabetes and Pregnancy (JSDP) for GDM (published during the COVID-19 pandemic) are used. Moreover, limited data is available regarding how widespread these diagnostic criteria are used when managing GDM during the COVID-19 pandemic. Therefore, this study aimed to determine how GDM diagnosis has changed during the COVID-19 pandemic in Japan. METHODS: The changes in GDM diagnosis during the COVID-19 pandemic were investigated using an online questionnaire to 2159 obstetric facilities in Japan. The questionnaire collected data on facility type, awareness of Japanese GDM diagnostic strategies, modifications to diagnostic methods for early and late GDM, and opinions on GDM management, with the pandemic divided into seven periods. RESULTS: We received responses from 593 facilities (27%). Approximately 90% of the facilities did not change their diagnostic process for early GDM or late GDM (occurring after 24 weeks gestation). However, during the COVID-19 pandemic, 19 facilities discontinued the use of 75-g oral glucose tolerance tests before 24 weeks of gestation, and 17 facilities discontinued it after 24 weeks of gestation, instead using the aforementioned Japanese GDM diagnostic strategy. CONCLUSIONS: Although a limited number of facilities modified their diagnostic method in response to the COVID-19 pandemic, this study demonstrated that those that adjusted their diagnostic method primarily used the Japanese COVID-19 GDM strategy by the JSDP.

  41. Transcatheter arterial embolization outperforms surgery in reducing blood transfusions for postpartum vulvovaginal hematoma. International-journal

    Tsukasa Takahashi, Hasumi Tomita, Hirotaka Hamada, Mari Tadakawa, Noriyuki Iwama, Masatoshi Saito

    American journal of obstetrics and gynecology　2024/03/20

    DOI： 10.1016/j.ajog.2024.03.016 　

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    BACKGROUND: Postpartum vulvovaginal hematoma is a complication of vaginal delivery that may progress to life-threatening conditions. However, the management of hematomas, including conservative therapy, surgery, and arterial embolization, is yet to be standardized. OBJECTIVE: This study aimed to i) evaluate hematoma features that can be treated conservatively, and ii) determine which is superior in reducing blood transfusion between surgery and transcatheter arterial embolization. STUDY DESIGN: This cross-sectional study included postpartum women transferred to Tohoku University Hospital, Japan, between January 2016 and September 2023 for postpartum vulvovaginal hematomas. Notably, all patients except one underwent contrast-enhanced computed tomography. The patients were classified into i) the conservative group who received neither surgery nor transcatheter atrial embolization and ii) the therapeutic intervention group who received surgery or transcatheter atrial embolization. The primary analysis included all patients. Variables for the choice of therapeutic intervention, including the shock index, hemoglobin concentration at arrival, hematoma size, and presence of extravasation, were assessed using a modified Poisson regression model. The secondary analysis included patients who received therapeutic intervention (i.e. surgery or transcatheter atrial embolization). Variables for estimating the total amount of blood transfusion, including shock index, hemoglobin concentration at arrival, hematoma size, type of intervention, and presence of extravasation, were analyzed using multiple linear regression. RESULTS: Fifty-seven cases were included in this study. Patients underwent conservative treatment (n= 19), surgery (n= 11), or transcatheter arterial embolization (n= 27). In primary analysis, only the presence of extravasation was significantly associated with the choice of therapeutic intervention (adjusted risk ratio [95% confidence interval], 5.30 [1.53, 18.37]). In the secondary analysis, the therapeutic option for surgery (unstandardized coefficients [95% confidence interval], 4.64 [1.15, 8.13], reference: transcatheter atrial embolization), lower hemoglobin concentration at arrival (-2.84 [-4.71, -0.97], 1 g/dL increment), and larger hematoma size (3.38 [1.23, 5.53], 100 cm3 increments) were significantly associated with increased blood transfusion. CONCLUSIONS: When a vulvovaginal hematoma does not undergo extravasation, it can be treated conservatively regardless of size. When a therapeutic intervention is selected, transcatheter arterial embolization reduces the total amount of blood transfusion compared with surgery.

  42. Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

    Journal of diabetes investigation　2024/02/23

    DOI： 10.1111/jdi.14159 　

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    AIMS: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). METHODS: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000-3499 g as the reference category. RESULTS: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were 1.345 (95% confidence interval [CI]: 0.912-1.984) and 1.338 (95% CI: 1.098-1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were, 1.657 (95% CI: 1.298-2.115) and 1.218 (95% CI: 1.058-1.402), respectively. CONCLUSIONS: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.

  43. Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study

    Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, The Japan Environment and Children’s Study Group

    Nutrients　2024/02/14

    DOI： 10.3390/nu16040531 　

  44. Long-Term and Short-Interval Assessment of Self-Reported Urinary and Sexual Functions after Nerve-Sparing Radical Hysterectomy: A Prospective Cohort Study.

    Masumi Ishibashi, Hitoshi Niikura, Motoko Ishida, Noriyuki Iwama, Hirohito Metoki, Shogo Shigeta, Tomoyuki Nagai, Hideki Tokunaga, Muneaki Shimada, Nobuo Yaegashi

    The Tohoku journal of experimental medicine　2024/02/08

    DOI： 10.1620/tjem.2024.J014 　

  45. Prediction of preterm preeclampsia risk in Asians using a simple two-item assessment in early pregnancy. International-journal

    Seiya Izumi, Noriyuki Iwama, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　2024/02/06

    DOI： 10.1038/s41440-024-01590-1 　

  46. The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children's study. International-journal

    Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Journal of developmental origins of health and disease　1-12　2024/01/22

    DOI： 10.1017/S2040174423000387 　

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    This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43-1.58) and 1.31 (95% CI, 1.25-1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47-1.60) and 1.41 (95% CI, 1.35-1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40-1.55) and 1.25 (95% CI, 1.19-1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41-1.79) and 1.40 (95% CI, 1.23-1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.

  47. Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. International-journal

    Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J Tsuchiya, Reiko Kishi, Shinichi Kuriyama

    Journal of human hypertension　2024/01/10

    DOI： 10.1038/s41371-023-00890-2 　

  48. Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community-based cohort study. International-journal

    Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

    Journal of clinical hypertension (Greenwich, Conn.)　2024/01/08

    DOI： 10.1111/jch.14756 　

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    This study investigated the association of parity with hypertension prevalence in Japanese women while considering a clinical history of hypertensive disorders of pregnancy (HDP) and menopausal status. This cross-sectional study included 30,530 Japanese women (6700 premenopausal; 23 830 postmenopausal). The association between parity and the prevalence of hypertension was evaluated using a multiple logistic regression model with possible confounders. In premenopausal women, no statistically significant association between parity and hypertension prevalence was found. When not adjusted for current body mass index (BMI), a linear graded association was observed between parity and the prevalence of hypertension in postmenopausal women. However, the association between parity and hypertension prevalence in postmenopausal women was attenuated after adjustment for current BMI. Both current BMI and a clinical history of HDP were significantly associated with a high risk of hypertension in both premenopausal and postmenopausal women. Our results also suggest that continuous surveillance and preventive measures for hypertension should be provided for women with HDP and high parity.

  49. The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium

    Kazue Ishitsuka, AURELIE PIEDVACHE, Sumitaka Kobayashi, Noriyuki Iwama, Tomoko Nishimura, Masahiro Watanabe, Hirohito Metoki, Hiroyoshi Iwata, Chihiro Miyashita, Mami Ishikuro, Taku Obara, Kenichi Sakurai, Mohammad Shafiur Rahman, Keiko Tanaka, Yoshihiro Miyake, Reiko Horikawa, Reiko Kishi, Kenji J. Tsuchiya, Chisato Mori, Shinichi Kuriyama, Naho Morisaki

    Nutrients　2024/01/05

    DOI： 10.3390/nu16020186 　

  50. 産後うつ・自殺問題の縦断的リスクと関連要因の検討 東北メディカル・メガバンク計画三世代コホート調査

    大類 真嗣, 小原 拓, 石黒 真美, 野田 あおい, 篠田 元気, 村上 慶子, 岩間 憲之, 千葉 一平, 中谷 久美, 畑中 里衣子, 小暮 真奈, 目時 弘仁, 菊谷 昌浩, 中谷 直樹, 寳澤 篤, 栗山 進一

    Journal of Epidemiology　34　(Suppl.)　158-158　2024/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  51. Maternal birth weight is an indicator of preterm delivery: the Japan environment and children’s study

    Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Journal of Developmental Origins of Health and Disease　2024

    DOI： 10.1017/S2040174424000126 　

  52. Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama

    Nutrition journal　22　(1)　66-66　2023/12/06

    DOI： 10.1186/s12937-023-00901-5 　

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    BACKGROUND: Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5-6, 3-4, and 0-2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years. RESULTS: The proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0-2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02-1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0-2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32-2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0-2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81-1.39 and OR 1.15 (95% CI 0.84-1.57), respectively. CONCLUSION: For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.

  53. Prenatal hypertension as the risk of eclampsia, HELLP syndrome, and critical obstetric hemorrhage. International-journal

    Tetsuya Akaishi, Kunio Tarasawa, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Miho Akaishi, Kiyohide Fushimi, Kenji Fujimori, Nobuo Yaegashi, Masatoshi Saito

    Hypertension research : official journal of the Japanese Society of Hypertension　2023/11/22

    DOI： 10.1038/s41440-023-01511-8 　

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    Critical bleeding is a common cause of maternal mortality in obstetric patients. However, the non-obstetric factors underlying critical obstetric bleeding remain uncertain. Therefore, this study aimed to clarify the impact of chronic hypertension on obstetric hemorrhage by evaluating a nationwide administrative database in Japan. Women who gave birth between 2018 and 2022 were enrolled. The primary outcome was critical hemorrhage requiring massive red blood cell (RBC) transfusion during childbirth. In total, 354, 299 eligible women were selected from the database. The maternal mortality rate was >1.0% among those who received a massive RBC transfusion (≥4000 cc), and this amount was used as the cutoff of the outcome. Critical hemorrhage was less frequent with elective Caesarean section (CS) compared with vaginal childbirth or emergent CS (odds ratio [OR], 0.38; 95% confidence interval, 0.30-0.47). Multiple logistic regression analysis adjusting for these obstetric risks revealed that a higher maternal age (adjusted OR [aOR] per 1 year, 1.07 [1.05-1.09]); oral medications with prednisolone (aOR, 2.5 [1.4-4.4]), anti-coagulants (aOR, 10 [5.4-19]), and anti-platelets (aOR, 2.9 [1.3-6.4]); and a prenatal history of hypertension (aOR, 2.5 [1.5-4.4]) and hypoproteinemia (aOR, 5.8 [1.7-20]) are the risks underlying critical obstetric hemorrhage. Prenatal history of hypertension was significantly associated with obstetric disseminated intravascular coagulation (OR, 1.9 [1.5-2.4]); Hemolysis, Elevated Liver enzymes, and Low platelet count (HELLP) syndrome (OR, 3.3 [2.7-4.2]); and eclampsia (OR, 6.1 [4.6-8.1]). In conclusion, a maternal prenatal history of hypertension is associated with the development of HELLP syndrome, eclampsia, and resultant critical hemorrhage. The incidence of HELLP syndrome and eclampsia increased more than fivefold in the presence of prenatal hypertension. However, the likelihood of subsequently developing DIC or experiencing critical bleeding did not change by the presence of prenatal hypertension.

  54. Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study. International-journal

    Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

    Pregnancy hypertension　34　159-168　2023/11/21

    DOI： 10.1016/j.preghy.2023.11.002 　

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    OBJECTIVES: This study aimed to investigate the association between maternal birth weight (MBW) and hypertensive disorders of pregnancy (HDP) according to the gestational age when HDP develops. STUDY DESIGN: A total of 77,345 subjects were included in this prospective birth cohort study. The association between MBW and HDP was investigated by a multinomial logistic regression model. MAIN OUTCOME MEASURES: Early-onset HDP (EO-HDP), preterm late-onset HDP (preterm LO-HDP), and term late-onset HDP (term LO-HDP). RESULTS: Lower MBW was associated with higher odds of preterm and term LO-HDP (p-values for trend < 0.0001 and = 0.0005, respectively). A linear association between MBW and EO-HDP was observed (p-values for trend = 0.0496). The shape of the association between MBW and preterm LO-HDP was a combination of the associations between MBW with EO-HDP or LO-HDP. The effect size of the association between MBW < 2,500 g and EO-HDP was lower than that of MBW < 2,500 g with preterm or term LO-HDP. The adjusted odds ratios for EO-HDP, preterm LO-HDP, and term LO-HDP in subjects with MBW < 2,500 g were 1.052 (95 % confidence interval [CI]: 0.665-1.664), 1.745 (95 % CI: 1.220-2.496), and 1.496 (95 % CI: 1.154-1.939), respectively. CONCLUSIONS: MBW was associated with HDP, regardless of gestational age when HDP developed. Furthermore, the association of MBW < 2,500 g with preterm or term LO-HDP was stronger than that with EO-HDP.

  55. 分娩回数と2型糖尿病の関連 東北メディカル・メガバンク計画地域住民コホート調査

    内堀 洪欣, 岩間 憲之, 湯脇 恵一, 中道 洋, 齋藤 昌利

    糖尿病と妊娠　23　(3)　S-124　2023/10

    Publisher: (一社)日本糖尿病・妊娠学会

    ISSN： 1347-9172

  56. 分娩回数と高血圧との関連 東北メディカル・メガバンク機構地域住民コホート調査

    内堀 洪欣, 岩間 憲之, 湯脇 恵一, 中道 洋, 濱田 裕貴, 富田 芙弥, 田上 和磨, 工藤 理永, 熊谷 奈津美, 目時 弘仁, 中谷 直樹, 寳澤 篤, 栗山 進一, 八重樫 伸生, 齋藤 昌利

    日本妊娠高血圧学会雑誌　29　G-06　2023/09

    Publisher: (一社)日本妊娠高血圧学会

    ISSN： 1880-3172

  57. 出生コホート連携における年齢別の不妊治療と妊娠高血圧症候群との関連

    石黒 真美, 小原 拓, 西村 倫子, 岩田 啓芳, 目時 弘仁, 岩間 憲之, 村上 慶子, Shafiur Rahman, 小林 澄貴, 宮下 ちひろ, 石塚 一枝, 田中 景子, 三宅 吉博, 堀川 玲子, 森崎 菜穂, 土屋 賢治, 岸 玲子, 栗山 進一

    DOHaD研究　11　(3)　36-36　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  58. Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Social psychiatry and psychiatric epidemiology　58　(11)　1593-1601　2023/06/03

    DOI： 10.1007/s00127-023-02498-w 　

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    PURPOSE: Studies examining the associations between maternal social relationships and early childhood development have mainly focused on social relationships after childbirth. We aimed to prospectively examine the associations between the transition of maternal social isolation from the prenatal to postnatal period and early childhood development. METHODS: We analyzed data for 6692 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social isolation in the prenatal and postnatal periods was assessed by the Lubben Social Network Scale-abbreviated version and categorized into four groups: none, prenatal only, postnatal only, and both. The Ages and Stages Questionnaire, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between maternal social isolation and developmental delays. RESULTS: The prevalence of social isolation in both the prenatal and postnatal periods was 13.1%. Social isolation in both the prenatal and postnatal periods was associated with developmental delays in children at 2 and 3.5 years of age: the multivariate-adjusted odds ratios (95% confidence intervals) were 1.68 (1.39-2.04) and 1.43 (1.17-1.76), respectively. Social isolation in the prenatal period only and social isolation in the postnatal period only were not associated with developmental delays in children at 2 and 3.5 years of age. CONCLUSION: Maternal social isolation in both the prenatal and postnatal periods was associated with an increased risk of developmental delays in early childhood.

  59. 「妊娠糖尿病について」 妊娠糖尿病診断基準の概要

    岩間 憲之, 齋藤 昌利, 杉山 隆

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P150-P150　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  60. 最近5年間の当院における産後出血搬送症例の検討

    富田 芙弥, 工藤 理永, 熊谷 奈津美, 高橋 新, 齋藤 翔子, 熊谷 祐作, 岩間 憲之, 只川 真理, 星合 哲郎, 齋藤 昌利

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P330-P330　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  61. 血管型Ehlers-Danlos syndrome合併妊娠の一例

    熊谷 奈津美, 富田 芙弥, 星合 哲郎, 岩間 憲之, 只川 真理, 熊谷 祐作, 齋藤 翔子, 高橋 新, 齋藤 昌利

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P413-P413　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  62. 妊娠中に捻転を来したparasitic myomaの一例

    高橋 新, 星合 哲郎, 熊谷 奈津美, 齋藤 翔子, 熊谷 祐作, 富田 芙弥, 只川 真理, 岩間 憲之, 齋藤 昌利

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P456-P456　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  63. 人工妊娠中絶前後に発熱・肝機能障害・血球減少・尿閉を呈したHSV感染症(Elsberg症候群)の一例

    齋藤 翔子, 齋藤 昌利, 只川 真理, 岩間 憲之, 富田 芙弥, 熊谷 祐作, 餅井 規吉, 熊谷 奈津美, 佐藤 壮樹, 高橋 新

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P464-P464　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  64. 人工妊娠中絶前後に発熱・肝機能障害・血球減少・尿閉を呈したHSV感染症(Elsberg症候群)の一例

    齋藤 翔子, 齋藤 昌利, 只川 真理, 岩間 憲之, 富田 芙弥, 熊谷 祐作, 餅井 規吉, 熊谷 奈津美, 佐藤 壮樹, 高橋 新

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P464-P464　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  65. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    BMC pregnancy and childbirth　23　(1)　268-268　2023/04/19

    DOI： 10.1186/s12884-023-05603-8 　

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    BACKGROUND: Low birth weight is associated with an increased risk of developing chronic diseases in adulthood, with a particularly high incidence in Japan among developed countries. Maternal undernutrition is a risk factor for low birth weight, but the association between the timing of food intake and infant birth weight has not been investigated. This study aimed to examine the association between breakfast intake frequency among Japanese pregnant women and infant birth weight. METHODS: Of all pregnant women who participated in the Tohoku Medical Megabank Project Three Generation Cohort Study, 16,820 who answered the required questions were included in the analysis. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: every day and 5-6, 3-4, and 0-2 times/week. Multivariate linear regression models were constructed to examine the association between breakfast intake frequency among pregnant women and infant birth weight. RESULTS: The percentage of pregnant women who consumed breakfast daily was 74% in the pre- to early pregnancy period and 79% in the early to mid-pregnancy period. The average infant birth weight was 3,071 g. Compared to women who had breakfast daily from pre- to early pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -38.2, 95% confidence interval [CI]: -56.5, -20.0). Similarly, compared to women who had breakfast daily from early to mid-pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -41.5, 95% CI: -63.3, -19.6). CONCLUSIONS: Less frequent breakfast intake before and mid-pregnancy was associated with lower infant birth weight.

  66. Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    European child & adolescent psychiatry　2023/03/30

    DOI： 10.1007/s00787-023-02199-4 　

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    It is essential to clarify factors associated with mental health and behavioral problems in early childhood, because children are critical stages of life for mental health. We aimed to prospectively examine the associations between maternal social isolation and behavioral problems in preschool children. We analyzed data from 5842 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores < 12) one year after delivery. The Child Behavior Checklist 1½-5 was used to assess behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations between social isolation and behavioral problems, after adjustment for age, education, income, work status, marital status, extraversion, neuroticism, depressive symptoms, child sex, and number of siblings. Multiple logistic regression analyses were also conducted for internalizing problems and externalizing problems. The prevalence of maternal social isolation was 25.4%. Maternal social isolation was associated with an increased risk of behavioral problems in children: the odds ratio (OR) was 1.37 (95% confidence interval [CI] 1.14-1.64). Maternal social isolation was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.33 (95% CI, 1.12-1.59) and 1.40 (95% CI, 1.18-1.66), respectively. In conclusion, maternal social isolation one year after delivery was associated with behavioral problems in children at 4 years of age.

  67. 母親における出産前後の社会的孤立と児の発達との関連 三世代コホート調査

    村上 慶子, 野田 あおい, 石黒 真美, 小原 拓, 上野 史彦, 菊地 紗耶, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 目時 弘仁, 齋藤 昌利, 菅原 準一, 富田 博秋, 八重樫 伸生, 栗山 進一

    日本衛生学雑誌　78　(Suppl.)　S173-S173　2023/03

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

    eISSN： 1882-6482

  68. Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Archives of women's mental health　26　(2)　219-226　2023/02/21

    DOI： 10.1007/s00737-023-01298-0 　

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    Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age.

  69. Precautions during Direct Oral Anticoagulant Introduction in Gynecologic Malignancies: A Single-Center Retrospective Cohort Study

    Takanori Shimizu, Noriyuki Iwama, Hideki Tokunaga, Shun Endo, Shuko Miyahara, Asami Toki, Zen Watanabe, Junko Minato, Chiaki Hashimoto, Masumi Ishibashi, Shogo Shigeta, Muneaki Shimada, Nobuo Yaegashi

    Cancers　2023/02/10

    DOI： 10.3390/cancers15041132 　

  70. Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of paediatrics and child health　59　(3)　548-554　2023/02/08

    DOI： 10.1111/jpc.16353 　

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    AIM: An association between maternal psychological distress and children's development has been reported, but  reports from Japan are limited. This study aimed to examine the association of maternal psychological distress with children's neurodevelopment in Japan. METHODS: The study assessed data of 7646 mother-infant pairs in the Japanese population. We used Kessler Psychological Distress Scale, a screening tool for psychological distress, to assess maternal psychological distress in early pregnancy and 2 years postpartum and divided it into four categories: none in both the pre-natal and post-natal periods, only the pre-natal period, only the post-natal period and both the pre-natal and post-natal periods. Children's neurodevelopment was assessed using the Ages & Stages Questionnaires Third Edition (ASQ-3) at 4 years of age. ASQ-3 comprises five domains (communication, gross motor, fine motor, problem solving and personal-social), and the score of less than -2 standard deviation relative to the mean in reference was defined as having developmental delay. We conducted multivariate logistic regression analysis to examine the association between maternal psychological distress and children's neurodevelopment. RESULTS: The prevalence of developmental delay of communication, gross motor, fine motor, problem solving and personal-social were 4.0%, 4.3%, 4.9%, 3.8% and 4.6%, respectively. Maternal psychological distress in only the postpartum period and both pre-natal and postpartum periods were associated with risks of developmental delay in all domains. Maternal psychological distress in only the pre-natal period was associated with developmental delay in communication. CONCLUSIONS: Maternal psychological distress is associated with risks of children's developmental delay.

  71. Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. International-journal

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　834-844　2023/02/03

    DOI： 10.1038/s41440-022-01144-3 　

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    Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

  72. 妊婦の朝食摂取頻度と児の出生体重との関連 東北メディカル・メガバンク計画三世代コホート調査

    相澤 美里, 村上 慶子, 高橋 一平, 大沼 ともみ, 野田 あおい, 松崎 芙実子, 上野 史彦, 石黒 真美, 小原 拓, 濱田 裕貴, 岩間 憲之, 齋藤 昌利, 菅原 準一, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　100-100　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  73. 母親の社会的孤立と児の問題行動の関連 東北メディカル・メガバンク計画三世代コホート調査

    村上 慶子, 石黒 真美, 小原 拓, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 高橋 一平, 菊地 紗耶, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 目時 弘仁, 菊谷 昌浩, 齋藤 昌利, 菅原 準一, 富田 博秋, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　33　(Suppl.1)　92-92　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  74. Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of affective disorders　325　582-587　2023/01/12

    DOI： 10.1016/j.jad.2023.01.044 　

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    BACKGROUND: Although there is some evidence that maternal perinatal mental disorders are associated with emotional/behavioral problems in children, the long-term impacts of postnatal bonding disorder remain unclear. We aimed to examine the associations between maternal postnatal bonding disorder and emotional/behavioral problems in preschool children. METHODS: We analyzed data from 7220 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score ≥5 at 1 month after delivery. The Child Behavior Checklist 1½-5 was used to assess emotional/behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations of postnatal bonding disorder with emotional/behavioral, internalizing, and externalizing problems after adjustment for age, education, income, parity, prenatal psychological distress, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. RESULTS: The prevalence of postnatal bonding disorder was 14.8 %. Postnatal bonding disorder was associated with an increased risk of emotional/behavioral problems in children: the odds ratio (OR) was 2.06 (95 % confidence interval [CI], 1.72-2.46). Postnatal bonding disorder was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.69 (95 % CI, 1.42-2.02) and 1.90 (95 % CI, 1.59-2.26), respectively. LIMITATIONS: Bonding and problems were self-reported. CONCLUSIONS: Bonding disorder at 1 month after delivery was associated with an increased risk of emotional/behavioral problems in children at 4 years of age.

  75. Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019. International-journal

    Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    Pregnancy hypertension　31　73-83　2023/01/09

    DOI： 10.1016/j.preghy.2023.01.001 　

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    OBJECTIVES: To evaluate the major congenital malformation (MCM) risk of first-trimester antihypertensive exposure, specifically of amlodipine and methyldopa. STUDY DESIGN: A large administrative claims database was used. MAIN OUTCOME MEASURES: The prevalence of antihypertensive prescriptions during pregnancy was described in 91,390 women giving birth between 2010 and 2019. The MCM risk of first-trimester antihypertensives was evaluated in 1,185 women diagnosed with hypertensive disorders in the first trimester. The MCM risk of first-trimester amlodipine and methyldopa was evaluated in 178 women who were prescribed antihypertensives in the first trimester. RESULTS: Antihypertensives were prescribed to 278 (0.30%) women during their first trimester. The prescription prevalence in the first trimester was highest for methyldopa (115, 0.13%), followed by amlodipine (55, 0.06%). Antihypertensives were prescribed to 2,955 (3.23%) women during pregnancy. Nifedipine (903, 0.99%) and nicardipine (758, 0.83%) were the most frequently prescribed oral and injectable antihypertensives during pregnancy, both with a significant increase in annual prevalence. Of the 1,185 women diagnosed with hypertensive disorders in the first trimester, antihypertensives were prescribed to 178 women. The adjusted odds ratio (aOR) of MCMs in the first-trimester prescription of any antihypertensive medication was 1.124 (95% confidence interval [CI], 0.618-2.045). Amlodipine and methyldopa were prescribed to 44 and 93 of the 178 women, respectively. The aORs of MCMs in the first-trimester prescription of amlodipine and methyldopa were 1.219 (95% CI, 0.400-3.721) and 0.921 (0.331-2.564), respectively. CONCLUSIONS: The MCM risk of first-trimester exposure to antihypertensives, including amlodipine and methyldopa, was not suggested.

  76. Dietary calcium intake was related to the onset of pre-eclampsia: The TMM BirThree Cohort Study. International-journal

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Ippei Takahashi, Fumiko Matsuzaki, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

    Journal of clinical hypertension (Greenwich, Conn.)　25　(1)　61-70　2022/12/28

    DOI： 10.1111/jch.14606 　

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    This study aimed to explore the relationship between dietary electrolyte intake and the prevalence of hypertensive disorders of pregnancy (HDP) subtypes. Our analysis included 19 914 pregnant women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. A food frequency questionnaire was used to estimate dietary calcium, potassium, sodium, and magnesium intakes. HDP was determined based on the medical records during regular antenatal care. Logistic regression analysis assessed the relationship between dietary electrolytes intake quintiles, and HDP subtypes with adjustment for basic characteristics. Dietary electrolyte intakes were applied for the prediction model. Of the cohort, 547 participants delivered with pre-eclampsia (PE), 278 with superimposed PE (SP), and 896 with gestational hypertension (GH). PE was associated with low crude calcium intake (odds ratio of the first quintile [<251 mg/day] to the fifth quintile [>623 mg/day] and 95% confidence interval, 1.31 [1.00-1.70]) and P for trend was .02. SP was not associated with any nutritional intake; however, the combined outcome of PE and SP was related to low crude calcium and potassium and energy-adjusted calcium, potassium, and magnesium intakes (P for trend, .01, .048, .02, .04, and .02, respectively). The same tendency was observed for GH. A prediction model that included crude calcium and potassium intakes performed better than a model without them. In conclusion, low dietary calcium, potassium, and magnesium were associated with higher HDP subtypes prevalence. The prediction model implied that crude calcium and potassium intakes might play a critical role in PE and SP pathogenesis.

  77. Pregnancy outcomes among female childhood, adolescent, and young adult cancer survivors assessed using internet-based nationwide questionnaire surveys in Japan. International-journal

    Toshiaki Yasuoka, Noriyuki Iwama, Kuniaki Ota, Junichi Hasegawa, Hirohito Metoki, Masatoshi Saito, Takashi Sugiyama, Nao Suzuki

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(26)　1-9　2022/12/25

    DOI： 10.1080/14767058.2022.2155037 　

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    OBJECTIVE: Female cancer survivors planning to become pregnant are concerned about the impact of cancer treatment on their ability to maintain normal pregnancy and the negative impact on their offspring. However, studies on the pregnancy outcomes of cancer survivors in Japan are limited. Therefore, this study aimed to investigate the pregnancy outcomes of female cancer survivors by comparing them with women without a history of malignant tumors in Japan. METHODS: This cross-sectional study included 3308 subjects, based on an internet-based questionnaire (self-reported) survey conducted in Japan. Differences in pregnancy outcomes, including multiple pregnancies, stillbirth, preterm birth (PTB), and infant birthweight, between cancer survivors and subjects without a history of malignant tumors, were evaluated using a generalized linear mixed-effects model with adjustment for possible confounding factors. RESULTS: Of 3308 subjects included in this study, 629 (19.0%) were cancer survivors, among whom cervical (40.4%), breast (19.1%), and thyroid (7.0%) malignancies were most frequent. 71 (2.2%) and 53 (1.6%) participants had a history of multiple pregnancies and stillbirth, respectively; 385 (11.8%), 179 (5.5%), and 137 (4.2%) participants, respectively, had histories of PTB at less than 37, 34, and 32 weeks of gestation. Further, 302 (10.7%), 326 (11.6%), and 330 (11.7%) participants delivered to low birthweight (LBW), small-for-gestational-age (SGA), and large-for-gestational-age (LGA) infants, respectively. Subjects with a history of cervical or breast cancers had significantly higher odds of PTB at <37 weeks of gestation (adjusted odds ratios [ORs], 1.87 [95% CI: 1.25-2.81] and 2.61 [95% CI: 1.77-3.86], respectively), preterm LBW infants (adjusted ORs, 2.70 [95% CI: 1.39-5.24] and 2.76 [95% CI: 1.03-7.38], respectively), and LGA infants (1.98 [95% CI: 1.36-2.89] and 1.99 [95% CI: 1.14-3.49], respectively), compared to those without a history of a malignant tumor. Subjects with a history of thyroid cancer had significantly higher odds of stillbirth (adjusted OR, 5.11 [95% CI: 1.11-23.5]). CONCLUSION: Cancer survivors had a higher risk of adverse pregnancy outcomes than those without a history of malignant tumors in Japan. Healthcare providers should consider the high likelihood of adverse pregnancy outcomes during preconception counseling for cancer survivors.

  78. Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study. International-journal Peer-reviewed

    Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    Nutrition journal　21　(1)　71-71　2022/11/17

    DOI： 10.1186/s12937-022-00822-9 　

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    BACKGROUND: Hypertensive disorders of pregnancy (HDP) adversely affect the prognosis of mother and child, and the prognosis depends on the subtype of HDP. Skipping breakfast may be associated with increased blood pressure due to disruption of the circadian clock, but the association with the development of HDP has not been studied. The purpose of this study was to examine the association between skipping breakfast and the development of HDP and HDP subtypes in Japanese pregnant women. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 18,839 who answered the required questions were included in the analysis. This study had a cross-sectional design. The breakfast intake frequency from pre-pregnancy to early pregnancy was classified into four groups: daily, 5-6 times per week, 3-4 times per week, and 0-2 times per week. HDP was classified into gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and severe preeclampsia (SuPE). Multiple logistic regression analysis and multinomial logistic analysis were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for breakfast intake frequency and development of HDP or HDP subtypes. We performed a stratified analysis based on energy intake. RESULTS: Of the participants, 74.3% consumed breakfast daily, and 11.1% developed HDP. Women who consumed breakfast 0-2 times per week had a higher risk of HDP (OR: 1.33, 95% CI: 1.14-1.56), CH (OR: 1.63, 95% CI: 1.21-2.19), and PE (OR: 1.68, 95% CI: 1.27-2.21) than those who consumed breakfast daily. No association was found between skipping breakfast and the risk of developing GH (OR: 1.26, 95% CI: 0.99-1.61) and SuPE (OR: 0.91, 95% CI: 0.55-1.49). Stratified analysis showed that the risk of developing HDP due to skipping breakfast was highest in the group with the highest daily energy intake. CONCLUSIONS: Skipping breakfast during pre-to early pregnancy is associated with the development of HDP. Further longitudinal studies are required to clarify the causal association between skipping breakfast and HDP.

  79. Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

    Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

    BMC psychiatry　22　(1)　693-693　2022/11/11

    DOI： 10.1186/s12888-022-04330-2 　

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    BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.

  80. Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Sleep health　8　(6)　714-720　2022/10/10

    DOI： 10.1016/j.sleh.2022.08.007 　

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    OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.

  81. 妊娠後期に胎児動脈管早期収縮を発症し、その原因としてポリフェノール過剰摂取を疑った1例

    村川 真理弥, 熊谷 祐作, 内堀 洪欣, 熊谷 奈津美, 圓山 晶子, 桃野 友太, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　69回　85-85　2022/10

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  82. 妊娠期乳癌に対する治療介入時期と新生児予後の症例集積研究

    後藤 なつみ, 遠藤 俊, 濱田 裕貴, 熊谷 祐作, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 星合 哲郎, 八重樫 伸生, 齋藤 昌利

    仙台医療センター医学雑誌　12　(3)　89-94　2022/10

    Publisher: (独)国立病院機構仙台医療センター

    ISSN： 2186-0920

    eISSN： 2186-3946

  83. 魚の摂取頻度と月経痛の有病率の長期的検討 エコチル調査における宮城ユニットセンター追加調査

    横山 絵美, 武田 卓, 渡邉 善, 岩間 憲之, 佐藤 倫広, 村上 任尚, 櫻井 香澄, 志賀 尚美, 龍田 希, 齋藤 昌利, 立花 眞仁, 有馬 隆博, 栗山 進一, 目時 弘仁, 八重樫 伸生

    日本女性医学学会雑誌　30　(1)　125-125　2022/10

    Publisher: (一社)日本女性医学学会

    ISSN： 2185-8861

  84. 妊娠後期に胎児動脈管早期収縮を発症し、その原因としてポリフェノール過剰摂取を疑った1例

    村川 真理弥, 熊谷 祐作, 内堀 洪欣, 熊谷 奈津美, 圓山 晶子, 桃野 友太, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　69回　85-85　2022/10

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  85. Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Journal of affective disorders　320　461-467　2022/09/30

    DOI： 10.1016/j.jad.2022.09.139 　

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    BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.

  86. Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Archives of Women's Mental Health　25　(6)　1079-1086　2022/09/17

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s00737-022-01266-0 　

    ISSN： 1434-1816

    eISSN： 1435-1102

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    Although there is substantial information about the effects of social relationships on mental health, their effects on postnatal bonding remain unclear. We aimed to examine the association between social isolation and postnatal bonding disorder. We analyzed data from 17,999 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. An abbreviated version of the Lubben Social Network Scale was used to assess social isolation in the second trimester of pregnancy, and its subscales were used to assess marginal family ties and marginal friendship ties. Bonding disorder was defined as a Mother-to-Infant Bonding Scale score of ≥ 5 1 month after delivery. Multiple logistic regression analyses were conducted to examine the association between social isolation and postnatal bonding disorder after adjusting for age at delivery, parity, feelings towards pregnancy, psychological distress during pregnancy, and household income. Analyses stratified by postnatal depressive symptoms (PDS) were also conducted. Social isolation was associated with postnatal bonding disorder: the odds ratio (OR) was 1.55 (95% confidence interval [CI], 1.41-1.71). Marginal family ties and friendship ties were associated with postnatal bonding disorder: the ORs were 1.40 (95% CI, 1.23-1.60) and 1.44 (95% CI, 1.32-1.57), respectively. Marginal family ties were associated with postnatal bonding disorder only among women without PDS: the ORs were 1.30 (95% CI, 1.10-1.55) among women without PDS and 1.13 (95% CI, 0.91-1.40) among women with PDS. Social isolation during pregnancy was associated with an increased risk of postnatal bonding disorder.

  87. Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study International-journal

    Takahiro Yamashita, Taku Obara, Yudai Yonezawa, Ippei Takahashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Noriyuki Iwama, Hirotaka Hamada, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Masatoshi Saito, Nobuo Yaegashi, Shinichi Kuriyama

    Nutrition Journal　21　(1)　57-57　2022/09/16

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12937-022-00808-7 　

    eISSN： 1475-2891

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    Abstract Background Although small for gestational age (SGA) is a serious problem worldwide, the association of dietary patterns before and during pregnancy with SGA risk is unclear. We evaluated this association among Japanese pregnant women using three methods: reduced rank regression (RRR) and partial least squares (PLS), methods for extracting dietary patterns that can explain the variation of response variables, and principal component analysis (PCA), a method for extracting dietary patterns of the population. Methods Between July 2013 and March 2017, 22,493 pregnant women were recruited to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a population-based prospective birth cohort study in Japan. Information on dietary intake was obtained using food frequency questionnaires, and dietary patterns were extracted using RRR, PLS, and PCA. Information on birth weight was obtained from obstetric records, and the birth weight SD score and SGA were defined by the method of the Japan Pediatric Society. The associations of dietary patterns with birth weight SD score and SGA risk were investigated using multiple linear regression and multiple logistic regression, respectively. Results A total of 17,728 mother-child pairs were included. The birth weight SD score was 0.15 ± 0.96, and the prevalence of SGA was 6.3%. The dietary patterns extracted by RRR and PLS were similar and characterized by a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages in both pre- to early pregnancy and from early to mid-pregnancy. Higher adoption of the RRR and PLS patterns in both periods was associated with an increased birth weight SD score and lower risk of SGA. In contrast, the PCA1 pattern was not associated with birth weight SD score or SGA risk in either period. Although the PCA2 pattern was associated with increased birth weight SD score from early to mid-pregnancy, no other associations with birth weight SD score or SGA risk were observed. Conclusions The dietary pattern with a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages before and during pregnancy was associated with a decreased SGA risk in Japan.

  88. Development and validation of claims-based algorithms to identify pregnancy based on data from a university hospital in Japan. International-journal

    Kentaro Tajima, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

    Current medical research and opinion　38　(9)　1651-1654　2022/09

    DOI： 10.1080/03007995.2022.2101817 　

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    OBJECTIVE: When using administrative data, validation is essential since these data are not collected for research purposes and misclassification can occur. Thus, this study aimed to develop algorithms identifying pregnancy and to evaluate the validity of administrative claims data in Japan. METHODS: All females who visited the Tohoku University Hospital Department of Obstetrics in 2018 were included. The diagnosis, medical procedure, medication, and medical service addition fee data were utilized to identify pregnancy, with the electronic medical records set as the gold standard. Combination algorithms were developed using predefined pregnancy-related claims data with a positive predictive value (PPV) ≥80%. Sensitivity (SE), specificity (SP), PPV, and negative predictive value (NPV) with their corresponding 95% confidence intervals (CIs) were calculated for these combination algorithms. RESULTS: This study included 1,757 females with a mean age of 32.8 (standard deviation: 5.9) years. In general, the individual claims data were able to identify pregnancy with a PPV ≥80%; however, the number of pregnancies identified using a single claims data was limited. Based on the combination algorithm with all of the categories, including diagnosis, medical procedure, medication, and medical service addition, the calculated SE, SP, PPV, and NPV were 73.4% (95% CI: 71.2%-75.4%), 96.9% (95% CI: 89.3%-99.6%), 99.8%,(95% CI: 99.4%-100.0%), and 12.3% (95% CI: 9.6%-15.4%), respectively. CONCLUSIONS: The combination algorithm to identify pregnancy demonstrated a high PPV and moderate SE. The algorithm validated in this study is expected to accelerate future studies that aim to identify pregnancies and evaluate pregnancy outcome.

  89. Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children's study. International-journal

    Nozomi Tatsuta, Miyuki Iwai-Shimada, Shoji F Nakayama, Noriyuki Iwama, Hirohito Metoki, Takahiro Arima, Kasumi Sakurai, Akane Anai, Kaname Asato, Shinichi Kuriyama, Junichi Sugawara, Kichiya Suzuki, Nobuo Yaegashi, Michihiro Kamijima, Kunihiko Nakai

    Environmental research　212　(Pt B)　113231-113231　2022/09

    DOI： 10.1016/j.envres.2022.113231 　

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    BACKGROUND: Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have been reported. This study aimed to examine the association between the maternal whole blood concentration of metallic elements (Hg, Pb, Cd, Mn, and Se) and GDM using the dataset of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study, which was designed to examine the adverse effects of pre/post-natal exposure to hazardous environment. METHODS: The data of 78,964 pregnant women who were participants of JECS were used. Blood samples were collected from the pregnant women at second/third trimester of gestation. We employed logistic regression analysis, quantile g-computation (QGC) and a distributed lag nonlinear model (DLNM) to examine the association between the blood concentration of metallic elements and the risk of GDM. RESULTS: The prevalence of GDM was 2.1%. In the logistic regression analyses, maternal blood Hg was associated with an increased risk of GDM. In QGC analysis, although metallic elements mixtures were not related to an increased risk of GDM, Hg (52.6%) may be the main contributor. According to the results of DLNM, for maternal exposure to Hg, 4.99 ng/g was identified as its susceptible minimum window for elevated risk of GDM. CONCLUSIONS: Our findings highlighted an association between Hg exposure and an increased risk of GDM. Studies of the underlying mechanisms and potential contributing factors, including fish intake, of this association are warranted.

  90. Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement. International-journal

    Hirohito Metoki, Noriyuki Iwama, Hirotaka Hamada, Michihiro Satoh, Takahisa Murakami, Mami Ishikuro, Taku Obara

    Hypertension research : official journal of the Japanese Society of Hypertension　45　(8)　1298-1309　2022/08

    DOI： 10.1038/s41440-022-00965-6 　

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    Hypertensive disorders of pregnancy increase the risk of adverse maternal and fetal outcomes. In 2018, the Japanese classification of hypertensive disorders of pregnancy was standardized with those of other countries, and a hypertensive disorder of pregnancy was considered to be present if hypertension existed during pregnancy and up to 12 weeks after delivery. Strategies for the prevention of hypertensive disorders of pregnancy have become much clearer, but further research is needed on appropriate subjects and methods of administration, and these have not been clarified in Japan. Although guidelines for the use of antihypertensive drugs are also being studied and standardized with those of other countries, the use of calcium antagonists before 20 weeks of gestation is still contraindicated in Japan because of the safety concerns that were raised regarding possible fetal anomalies associated with their use at the time of their market launch. Chronic hypertension is now included in the definition of hypertensive disorders of pregnancy, and blood pressure measurement is a fundamental component of the diagnosis of hypertensive disorders of pregnancy. Out-of-office blood pressure measurements, including ambulatory and home blood pressure measurements, are important for pregnant and nonpregnant women. Although conditions such as white-coat hypertension and masked hypertension have been reported, determining their occurrence in pregnancy is complicated by the gestational week. This narrative review focused on recent reports on hypertensive disorders of pregnancy, including those related to blood pressure measurement and classification.

  91. Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. International-journal

    Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Tatsui Otsuka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito, Junichi Sugawara, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

    BMJ open　12　(6)　e060944　2022/06/07

    DOI： 10.1136/bmjopen-2022-060944 　

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    OBJECTIVES: This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3. RESULTS: Of 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37). CONCLUSION: In this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.

  92. 超緊急帝王切開の手術決定から胎児娩出までに要した時間と継続的なシミュレーションの有用性

    工藤 理永, 濱田 裕貴, 岩間 憲之, 富田 芙弥, 熊谷 奈津美, 高橋 新, 田上 和磨, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　213-213　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  93. 妊娠24週未満の空腹時血糖およびHbA1cと妊娠高血圧症候群との関連 BOSHI研究

    泉 聖也, 岩間 憲之, 濱田 裕貴, 齋藤 昌利, 杉山 隆, 八重樫 伸生, 目時 弘仁

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　250-250　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  94. 当施設において特別養子縁組の斡旋を行った妊産婦の背景 症例集積研究

    村川 東, 星合 哲郎, 濱田 裕貴, 工藤 理恵, 高橋 新, 熊谷 奈津美, 桃野 友太, 齋藤 翔子, 熊谷 祐作, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　277-277　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  95. 宮城県における飛び込み分娩の症例集積研究 コロナ禍前後での違い

    田上 和磨, 星合 哲郎, 濱田 裕貴, 熊谷 奈津美, 工藤 理永, 高橋 新, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　277-277　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  96. 前回常位胎盤早期剥離の診断時期と次回妊娠の周産期予後との関連

    高橋 新, 岩間 憲之, 工藤 理永, 熊谷 奈津美, 田上 和磨, 富田 芙弥, 濱田 裕貴, 只川 真理, 大塩 清佳, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　302-302　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  97. 超緊急帝王切開の手術決定から胎児娩出までに要した時間と継続的なシミュレーションの有用性

    工藤 理永, 濱田 裕貴, 岩間 憲之, 富田 芙弥, 熊谷 奈津美, 高橋 新, 田上 和磨, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　213-213　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  98. 妊娠24週未満の空腹時血糖およびHbA1cと妊娠高血圧症候群との関連 BOSHI研究

    泉 聖也, 岩間 憲之, 濱田 裕貴, 齋藤 昌利, 杉山 隆, 八重樫 伸生, 目時 弘仁

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　250-250　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  99. 当施設において特別養子縁組の斡旋を行った妊産婦の背景 症例集積研究

    村川 東, 星合 哲郎, 濱田 裕貴, 工藤 理恵, 高橋 新, 熊谷 奈津美, 桃野 友太, 齋藤 翔子, 熊谷 祐作, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　277-277　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  100. 宮城県における飛び込み分娩の症例集積研究 コロナ禍前後での違い

    田上 和磨, 星合 哲郎, 濱田 裕貴, 熊谷 奈津美, 工藤 理永, 高橋 新, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　277-277　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  101. 前回常位胎盤早期剥離の診断時期と次回妊娠の周産期予後との関連

    高橋 新, 岩間 憲之, 工藤 理永, 熊谷 奈津美, 田上 和磨, 富田 芙弥, 濱田 裕貴, 只川 真理, 大塩 清佳, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　302-302　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  102. Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study. International-journal

    Noriyuki Iwama, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Tetsuro Hoshiai, Masatoshi Saito, Hirohito Metoki, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

    Scientific reports　12　(1)　8921-8921　2022/05/26

    DOI： 10.1038/s41598-022-12892-0 　

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    This study aimed to construct a prediction model for small-for-gestational-age (SGA) infants in Japan by creating a risk score during pregnancy. A total of 17,073 subjects were included in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study. A multiple logistic regression model was used to construct risk scores during early and mid-gestational periods (11-17 and 18-21 weeks of gestation, respectively). The risk score during early gestation comprised the maternal age, height, body mass index (BMI) during early gestation, parity, assisted reproductive technology (ART) with frozen-thawed embryo transfer (FET), smoking status, blood pressure (BP) during early gestation, and maternal birth weight. The risk score during mid-gestation also consisted of the maternal age, height, BMI during mid-gestation, weight gain, parity, ART with FET, smoking status, BP level during mid-gestation, maternal birth weight, and estimated fetal weight during mid-gestation. The C-statistics of the risk scores during early- and mid-gestation were 0.658 (95% confidence interval [CI]: 0.642-0.675) and 0.725 (95% CI: 0.710-0.740), respectively. In conclusion, the predictive ability of the risk scores during mid-gestation for SGA infants was acceptable and better than that of the risk score during early gestation.

  103. 胎児機能不全による超緊急帝王切開術中に絞扼性腸閉塞と診断した1例

    武蔵 実久, 熊谷 祐作, 櫻田 昂大, 工藤 理永, 桃野 友太, 富田 芙弥, 濱田 裕貴, 只川 真理, 岩間 憲之, 星合 哲郎, 齋藤 昌利

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集　151回　46-46　2022/05

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  104. 卵管間質部妊娠術後妊娠と子宮破裂 当施設における症例集積検討と系統的文献レビュー

    成重 さつき, 濱田 裕貴, 山口 峻史, 工藤 理永, 熊谷 奈津美, 桃野 友太, 齋藤 翔子, 熊谷 祐作, 横山 絵美, 富田 芙弥, 岩間 憲之, 大塩 清佳, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集　151回　54-54　2022/05

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  105. 当施設において特別養子縁組の斡旋を行った妊産婦に対する症例集積検討

    村川 東, 星合 哲郎, 濱田 裕貴, 成重 さつき, 山口 峻史, 工藤 理永, 熊谷 奈津美, 高橋 新, 宮副 美奈子, 桃野 友太, 齋藤 翔子, 熊谷 祐作, 富田 芙弥, 只川 真理, 岩間 憲之, 大塩 清佳, 齋藤 昌利, 八重樫 伸生

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集　151回　55-55　2022/05

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  106. Validity of Administrative Data for Identifying Birth-Related Outcomes with the End Date of Pregnancy in a Japanese University Hospital. International-journal

    Kentaro Tajima, Tomofumi Ishikawa, Fumiko Matsuzaki, Aoi Noda, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano

    International journal of environmental research and public health　19　(8)　2022/04/16

    DOI： 10.3390/ijerph19084864 　

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    This study aimed to develop and validate claims-based algorithms for identifying live birth, fetal death, and cesarean section by utilizing administrative data from a university hospital in Japan. We included women who visited the Department of Obstetrics at a university hospital in 2018. The diagnosis, medical procedures, and medication data were used to identify potential cases of live birth, fetal death, and cesarean section. By reviewing electronic medical records, we evaluated the positive predictive values (PPVs) and the accuracy of the end date of pregnancy for each claims datum. "Selected algorithm 1" based on PPVs and "selected algorithm 2" based on both the PPVs and the accuracy of the end date of pregnancy were developed. A total of 1757 women were included, and the mean age was 32.8 years. The PPVs of "selected algorithm 1" and "selected algorithm 2" were both 98.1% for live birth, 99.0% and 98.9% for fetal death, and 99.7% and 100.0% for cesarean section, respectively. These findings suggest that the developed algorithms are useful for future studies for evaluating live birth, fetal death, and cesarean section with an accurate end date of pregnancy.

  107. Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

    Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

    Scientific reports　12　(1)　6400-6400　2022/04/16

    DOI： 10.1038/s41598-022-09944-w 　

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    Personality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.

  108. 日本人妊婦の食事パターンとSGAとの関連 三世代コホート調査

    山下 貴宏, 小原 拓, 米沢 祐大, 高橋 一平, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 岩間 憲之, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  109. Association of fish intake with menstrual pain: A cross-sectional study of the Japan Environment and Children's Study. International-journal

    Emi Yokoyama, Takashi Takeda, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kasumi Sakurai, Naomi Shiga, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

    PloS one　17　(7)　e0269042　2022

    DOI： 10.1371/journal.pone.0269042 　

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    The relationship between fish eating habits and menstrual pain is unknown. Elucidating this relationship can inform dietary guidance for reproductive age women with menstrual pain. The aim of this study was to clarify the relationship between fish intake frequency/preference and menstrual pain. This cross-sectional study was conducted at the Miyagi Regional Center as an adjunct study of the Japan Environment and Children's Study, and 2060 eligible women (mean age, 31.9 years) participated. Fish intake frequency ("< 1 time/week," "1 time/week," "2-3 times/week," or "≥ 4 times/week"), preference ("like," "neutral," or "dislike"), and menstrual pain (no/mild or moderate-to-severe) were assessed at 1.5 years after the last delivery through self-administered questionnaires. The association between fish intake frequency/preference and prevalence of moderate-to-severe menstrual pain was evaluated through logistic regression analyses. Our results show that, compared with the "< 1 time/week" (38.0%) group, the "1 time/week" (26.9%), "2-3 times/week" (27.8%), and "≥ 4 times/week" (23.9%) groups showed a lower prevalence of moderate-to-severe menstrual pain (p < 0.01). The prevalence of moderate-to-severe menstrual pain was 27.7%, 27.6%, and 34.4% in the "like," "neutral," and "dislike" groups, respectively. Multivariate logistic regression showed that frequent fish intake was associated with a lower prevalence of moderate-to-severe menstrual pain ("1 time/week": odds ratio [OR] = 0.59; 95% confidence interval [CI], 0.41-0.86, "2-3 times/week": OR = 0.64; 95% CI, 0.45-0.90 and "≥ 4 times/week": OR = 0.52; 95% CI, 0.34-0.80; trend p = 0.004). Multivariate logistic regression showed no association between fish preference and moderate-to-severe menstrual pain ("dislike" vs "like": OR = 1.16; 95% CI, 0.78-1.73). There was a significant negative association between fish intake frequency and menstrual pain. It is suggested that fish intake can reduce or prevent menstrual pain.

  110. 日本人妊婦の食事パターンとSGAとの関連 三世代コホート調査

    山下 貴宏, 小原 拓, 米沢 祐大, 高橋 一平, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 岩間 憲之, 菅原 準一, 鈴木 重徳, 菅沼 大行, 栗山 進一

    Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  111. Association of subjective health and abnormal cervical cytology in Japanese pregnant women: An adjunct study of the Japan Environment and Children's Study. International-journal

    Satomi Sasaki, Hirohito Metoki, Michihiro Satoh, Takahisa Murakami, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Zen Watanabe, Satoshi Okamoto, Masatoshi Saito, Junichi Sugawara, Kiyoshi Ito, Nobuo Yaegashi

    Preventive medicine reports　24　101525-101525　2021/12

    DOI： 10.1016/j.pmedr.2021.101525 　

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    This study examines the association between abnormal cervical cytology and subjective health in pregnant women, as an adjunct to the Japan Environment and Children's Study, which cross-sectionally analyzed a subset of the prospective cohort. A total of 3024 pregnant women at a childbirth facility whose medical records of cervical cytology in the first trimester of pregnancy were transcribed and who responded to the subjective health questionnaire were included herein. They were classified into excellent, good, fair, and poor groups based on their subjective health. Cervical cytology results obtained from perinatal medical records were classified into normal and abnormal cytology based on the Bethesda classification. Logistic regression analysis adjusted for baseline characteristics, including age, pre-pregnancy body mass index, parity, and other possible confounding factors, was used. Of 3024 pregnant women, 106 (3.5%) had abnormal cytology, with the prevalence being 1.3%, 3.7%, 3.9%, and 4.0%, respectively (p = 0.055) in the poor, fair, good, and excellent groups. The baseline characteristics, namely age, history of gynecological diseases, Kessler 6-item psychological distress scale score, and history of mental illness, were significantly different between groups. Compared to the poor group, the other three groups had a significantly higher abnormal cytology risk after adjusting for confounding factors (Fair: adjusted OR [aOR] = 3.6, 95% CI [1.0-12.1]; Good: aOR = 4.6 [1.3-15.5]; Excellent: aOR = 4.6 [1.2-17.8]). This study encourages young women to undergo cervical cancer screening because they are at risk for cervical cancer even if they think that they are healthy, and preventive activities like regular screening are essential.

  112. Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

    Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

    2021/09/15

    Publisher: Research Square Platform LLC

    DOI： 10.21203/rs.3.rs-887730/v1 　

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    <title>Abstract</title> ObjectiveThe aim of our study was to develop prediction model for preeclampsia (PE) using routinely examined items in early pregnancy especially dipstick test for proteinuria.MethodThe Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women and we included 9,086 of them in analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test of proteinuria were obtained by medical record at regular antenatal care. The outcome was defined as PE including superimposed preeclampsia. We developed prediction model without dipstick test of proteinuria (model 1) and model with it (model 2), and we compared them by the mean of area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation.ResultsmAUROC of model 1 was 0.769 (95% CI; 0.741 to 0.797) and that of model 2 was 0.785 (95% CI; 0.758 to 0.812). The difference of two mAUROCs was 0.016 (95% CI; 0.004 to 0.028). In model 2, detection rates at false-positive rate of 5%, 10% and 20% were 40%, 49% and 64%, respectively.ConclusionsWe could develop prediction model for PE using routine antenatal care items and it was improved by including dipstick test for proteinuria.

  113. Pregnancy outcomes in children, adolescents, and young adults that survived cancer: A nationwide survey in Japan. International-journal

    Toshiaki Yasuoka, Noriyuki Iwama, Kuniaki Ota, Miyuki Harada, Junichi Hasegawa, Nobuo Yaegashi, Takashi Sugiyama, Nao Suzuki, Yutaka Osuga

    The journal of obstetrics and gynaecology research　47　(9)　3352-3361　2021/09

    Publisher: Wiley

    DOI： 10.1111/jog.14909 　

    ISSN： 1341-8076

    eISSN： 1447-0756

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    AIM: Recent advances in cancer treatment have improved the prognosis of child, adolescent, and young adult (CAYA) cancer survivors. This study aimed to examine the current status of pregnancy outcomes among female cancer survivors in Japan. METHODS: The first questionnaire was sent to 633 major tertiary institutions certified by the Japan Society of Obstetrics and Gynecology to identify institutions managing cases of pregnant cancer survivors between January 2011 and December 2015. The second questionnaire was sent only to institutions with pregnant cancer survivors during the study period. RESULTS: We analyzed 2242 singleton deliveries of cancer survivors based on the responses received in the second questionnaire (199/255 responses; 78.0%). The three most frequent types of malignant tumors were uterine cervical (23.4%), breast (17.6%), and thyroid cancers (17.5%). Conception was aided by the use of assisted reproductive technology in 17.0% of the patients. The proportions of mothers aged 35-39.9 and ≥ 40 years were 36.5% and 11.8%, respectively. The prevalence of preterm birth (PTB) at <37, <34, and < 32 weeks' gestation were 16.7%, 6.8%, and 4.3%, respectively. The proportion of infants with low birth weight (LBW) was 18.9%. CONCLUSION: The present study findings suggest that advanced maternal age was common among pregnant cancer survivors and these survivors often gave birth to PTB and LBW infants in Japan. The likelihood of adverse pregnancy outcomes should be considered by healthcare providers when planning counseling and perinatal care for cancer survivors.

  114. Mycoplasma hominisが起因であった帝王切開術後骨盤内膿瘍の1例

    木村 翔太, 山口 峻史, 小針 諄也, 佐藤 壮樹, 西本 光男, 岩間 憲之, 齋藤 昌利

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　68回　70-70　2021/08

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  115. 魚摂取頻度はPMS/PMDDの有病率に関連する エコチル調査における宮城ユニットセンター追加調査

    横山 絵美, 武田 卓, 渡邉 善, 岩間 憲之, 齋藤 昌利, 星合 哲郎, 立花 眞仁, 目時 弘仁, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　68回　44-44　2021/08

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  116. Mycoplasma hominisが起因であった帝王切開術後骨盤内膿瘍の1例

    木村 翔太, 山口 峻史, 小針 諄也, 佐藤 壮樹, 西本 光男, 岩間 憲之, 齋藤 昌利

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　68回　70-70　2021/08

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  117. 妊娠12週に経腹的子宮頸管縫縮術を施行し生児を得た1症例

    森部 絢子, 齋藤 昌利, 星合 哲郎, 岩間 憲之, 只川 真理, 齋藤 翔子, 八重樫 伸生

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P185-P185　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  118. 当院における臍帯卵膜付着症例を対象とした症例集積研究

    齋藤 翔子, 岩間 憲之, 齋藤 裕也, 熊谷 祐作, 森部 絢子, 富田 芙弥, 齋藤 彰治, 濱田 裕貴, 只川 真理, 大塩 清佳, 星合 哲郎, 齋藤 昌利

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P200-P200　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  119. 当院における広汎子宮頸部全摘術後妊娠に対する周産期管理の検討

    鈴木 真理, 濱田 裕貴, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P237-P237　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  120. 妊娠期乳がんに対する治療介入時期と新生児予後の症例集積検討

    遠藤 俊, 濱田 裕貴, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P240-P240　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  121. 卵管間質部妊娠術後妊娠の子宮破裂に関する検討 当施設における後方視的検討と系統的文献レビュー

    濱田 裕貴, 佐藤 直人, 齊藤 裕也, 森部 絢子, 富田 芙弥, 齋藤 彰治, 只川 真理, 岩間 憲之, 大塩 清佳, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P266-P266　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  122. 妊娠24週未満の空腹時血糖と妊娠高血圧症候群との関連 BOSHI研究

    泉 聖也, 岩間 憲之, 齋藤 昌利, 杉山 隆, 八重樫 伸生, 目時 弘仁

    日本周産期・新生児医学会雑誌　57　(Suppl.)　P221-P221　2021/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  123. CAYA世代がん経験者のソーシャルキャピタルの実態と関連要因の検討

    太田 邦明, 安岡 稔晃, 岩間 憲之, 長谷川 潤一, 杉山 隆, 鈴木 直, 令和2年度厚生労働科学研究班

    日本産科婦人科学会雑誌　73　(臨増)　S-384　2021/03

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  124. The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake.

    Kaou Tanoue, Zen Watanabe, Hidekazu Nishigori, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kousuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Environmental health and preventive medicine　26　(1)　27-27　2021/02/26

    DOI： 10.1186/s12199-021-00944-2 　

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    BACKGROUND: To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan. METHODS: This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children's Study. We then compared the prevalence and risk of distress in women in Miyagi Regional Center and women in the 13 regional centers for 3 years after the disaster. RESULTS: Women in the Miyagi Regional Center suffered more psychological distress than those in the 13 regional centers: OR 1.38 (95% CI, 1.03-1.87) to 1.92 (95% CI, 1.42-2.60). Additionally, women in the inland area had a consistently higher prevalence of psychological distress compared to those from the 13 regional centers: OR 1.67 (95% CI, 1.18-2.38) to 2.19 (95% CI, 1.60-2.99). CONCLUSIONS: The lack of pre-disaster data in the Japan Environment and Children's Study made it impossible to compare the incidence of psychological distress before and after the March 2011 Great East Japan Earthquake. However, 3 years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress did not improve in Miyagi Regional Center. Further, the prevalence of mental illness in inland areas was consistently higher than that in the 13 regional centers after the disaster.

  125. Small for gestational age児を予測するリスクスコアの検討 三世代コホート調査

    岩間 憲之, 小原 拓, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 星合 哲郎, 齋藤 昌利, 目時 弘仁, 菅原 準一, 八重樫 伸生, 栗山 進一

    Journal of Epidemiology　31　(Suppl.)　130-130　2021/01

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  126. Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children's Study (JECS). International-journal Peer-reviewed

    Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Masatoshi Saito, Tetsuro Hoshiai, Zen Watanabe, Kosuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hidekazu Nishigori, Shin-Ichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Diabetes research and clinical practice　169　108377-108377　2020/11

    DOI： 10.1016/j.diabres.2020.108377 　

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    AIMS: To investigate the associations between glycosylated hemoglobin (HbA1c) levels at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan. METHODS: This was a prospective nationwide birth cohort study of 77,526 subjects with an HbA1c level of <6.5% (<48 mmol/mol) at less than 24 weeks of gestation. Associations of HbA1c level with adverse pregnancy outcomes were evaluated using multivariate analyses. RESULTS: The adjusted odds ratios per 1% (11 mmol/mol) increase in HbA1c level were 1.77 (95% confidence interval [CI]: 1.48-2.12) for hypertensive disorders of pregnancy; 1.78 (95% CI: 1.12-2.83) for placental abruption; 1.30 (95% CI: 1.12-1.50) for preterm birth; 2.11 (95% CI: 1.41-3.16) for very preterm birth; 1.49 (95% CI: 1.33-1.68) for low birth weight infants; 1.95 (95% CI: 1.42-2.70) for macrosomia; 1.23 (95% CI: 1.09-1.39) for small for gestational age; 1.15 (95% CI: 1.04-1.28) for large for gestational age; and 1.29 (95% CI: 1.20-1.39) for the composite adverse pregnancy outcome. CONCLUSIONS: The higher the HbA1c level, the higher the risk of adverse pregnancy outcomes in Japan. Further studies will be needed to determine prenatal management based on the HbA1c level in pregnant women with HbA1c <6.5% (<48 mmol/mol) at less than 24 weeks of gestation.

  127. Epidemiological studies regarding hypertensive disorders of pregnancy: A review. International-journal Peer-reviewed

    Noriyuki Iwama, Mami Ishikuro, Kosuke Tanaka, Michihiro Satoh, Takahisa Murakami, Hirohito Metoki

    The journal of obstetrics and gynaecology research　46　(9)　1672-1677　2020/09

    DOI： 10.1111/jog.14383 　

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    A hypertensive disorder of pregnancy (HDP) is defined as hypertension emerging after 20 weeks of gestation and resolving up to 12 weeks post-partum, and occurs in about 5% of all pregnancies. Complications associated with HDP have poor prognoses, and maternal deaths attributable to HDP are predicted to exceed 70 000 per year worldwide. Understanding the pathogenesis and risk factors of hypertensive disorders of pregnancy is important, and they are often investigated in observational studies. Given that therapeutic interventions cannot be controlled in observed studies, it is necessary to interpret which factors correspond to exposure and which factors correspond to confounding and intermediate factors in each study. From the Babies and their parents' longitudinal observation in the Suzuki Memorial Hospital on Intrauterine period study, blood pressure in early pregnancy was not only predictive of a child's birthweight, but the trajectory was also associated with the birthweight. From the larger-scale birth cohort studies currently conducted in Japan will provide the novel potential risk factors of hypertensive disorders of pregnancy and preventive strategies of them. In Japan, observational or intervention studies are just beginning to emerge. The continuation of both a distinctive cohort and a large cohort is needed, and the development of good quality intervention trials based on the results of observational studies is important.

  128. Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. International-journal Peer-reviewed

    Noriyuki Iwama, Mari S Oba, Michihiro Satoh, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Satomi Sasaki, Masatoshi Saito, Yoshitaka Murakami, Shin-Ichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　43　(6)　550-559　2020/06

    DOI： 10.1038/s41440-020-0416-2 　

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    This study investigated the association between maternal home blood pressure (HBP) trajectory during pregnancy and infant birth weight. A total of 755 pregnant women were included in this prospective cohort study. A group-based trajectory model identified six trajectory groups for home systolic blood pressure (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Next, the association of HBP trajectory groups with infant birth weight was evaluated using a general linear model considering potential confounding factors. For home SBP and MAP, the trajectory groups with a low-steep J-curve, moderate J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the low-J-curve group. Among the trajectory groups for home DBP, the moderate-steep J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the group with low-J-curve. The effect sizes of the trajectory groups varied in infant birth weight from -0.21 standard deviations (SDs) (95% confidence interval (CI): -0.42 to -0.01 SD) to -1.13 SD (95% CI: -1.54 to -0.72 SD). In the analyses of infant birth weight in grams, effect sizes that were significantly associated with infant birth weight varied from -84 g (95% CI: -167 to -1 g) to -567 g (95% CI: -732 to -402 g). Trajectory groups with a moderate-reverse J-curve for home SBP, DBP, and MAP were not significantly associated with infant birth weight. Maternal HBP trajectory during pregnancy was an indicator of infant birth weight. Further studies evaluating the associations between HBP during pregnancy and other perinatal outcomes are needed.

  129. 妊娠初期の家庭血圧レベルと短期及び長期の母児予後との関連

    目時 弘仁, 佐藤 倫広, 村上 任尚, 岩間 憲之, 佐々木 里美, 高畠 恭介, 石黒 真美, 小原 拓, 菊谷 昌浩, 大久保 孝義, 八重樫 伸生, 星 和彦, 今井 潤

    宮城県公衆衛生学会会誌　(52)　13-13　2020/04

    Publisher: 宮城県公衆衛生学会

    ISSN： 0912-747X

  130. Comparison of pregnancy outcomes between women with early-onset and late-onset gestational diabetes in a retrospective multi-institutional study in Japan. Peer-reviewed

    Tomoka Usami, Maki Yokoyama, Megumi Ueno, Noriyuki Iwama, Norimasa Sagawa, Reo Kawano, Masako Waguri, Hiroshi Sameshima, Yuji Hiramatsu, Takashi Sugiyama

    Journal of diabetes investigation　11　(1)　216-222　2020/01

    DOI： 10.1111/jdi.13101 　

    ISSN： 2040-1116

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    AIMS/INTRODUCTION: To compare pregnancy outcomes between women with gestational diabetes mellitus (GDM) diagnosed early and late in pregnancy in Japan. MATERIALS AND METHODS: We examined women diagnosed with GDM in this multi-institutional retrospective study. Women were divided into two groups by gestational age at diagnosis: <24 weeks of gestation (early group, 14.4 ± 4.2 weeks) and ≥24 weeks of gestation (late group, 29.6 ± 3.4 weeks). Dietary counseling with self-monitoring of blood glucose with or without insulin therapy was initiated for both groups. Pregnancy outcomes were compared between the groups. RESULTS: Data from 600 early and 881 late group participants from 40 institutions were included. Although pre-pregnancy body mass index was higher in the early group than in the late group, gestational weight gain was lower in the early group. Hypertensive disorders of pregnancy and cesarean section were more prevalent in the early than in the late group (9.3% vs 4.8%, P < 0.001; 34.2% vs 32.0%, P < 0.001, respectively). The prevalence of large-for-gestational-age infants was higher in the late than in the early group (24.6% vs 19.7%, respectively, P = 0.025). There was no significant difference in other neonatal adverse outcomes between the groups. Multiple logistic regression analysis showed that early group, nulliparity and pre-pregnancy body mass index were associated with hypertensive disorders of pregnancy. CONCLUSIONS: These results suggest that maternal complications, including hypertensive disorders of pregnancy and cesarean delivery, were higher in the early group than in the late group. Earlier intervention for GDM might be associated with a reduction in large-for-gestational-age infants.

  131. Difference in the prevalence of gestational diabetes mellitus according to gestational age at 75-g oral glucose tolerance test in Japan: The Japan Assessment of Gestational Diabetes Mellitus Screening trial. Peer-reviewed

    Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Hideto Kusaka, Nobuo Yaegashi, Norimasa Sagawa, Yuji Hiramatsu, Nagayasu Toyoda

    Journal of diabetes investigation　10　(6)　1576-1585　2019/11

    DOI： 10.1111/jdi.13044 　

    ISSN： 2040-1116

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    AIMS/INTRODUCTION: To evaluate the differences in the results of 75-g oral glucose tolerance tests (OGTTs) according to gestational age in Japan. MATERIALS AND METHODS: In this prospective cohort study, 2,578 pregnant women were divided into three categories based on their gestational age during the 75-g OGTT: <14 weeks' gestation, 14-23 weeks' gestation and 24-32 weeks' gestation. The association between gestational age and the results of the 75-g OGTT were evaluated using multivariable analysis. RESULTS: Early gestational age was associated with high fasting plasma glucose levels at the time of the 75-g OGTT, and low corresponding 1-h and 2-h plasma glucose levels. Compared with women with a gestational age of 24-32 weeks, women who had undergone the 75-g OGTT at <14 weeks' gestation had significantly higher odds of gestational diabetes mellitus diagnosis based on the currently used criteria in Japan (adjusted odds ratio 1.42, 95% confidence interval 1.07-1.90). CONCLUSIONS: The results of the 75-g OGTT varied by gestational age. The use of the same 75-g OGTT cut-off values for the diagnosis of gestational diabetes mellitus, regardless of gestational age, might lead to increases in the prevalence of gestational diabetes mellitus diagnosis in Japan.

  132. Paternal height has an impact on birth weight of their offspring in a Japanese population: the Japan Environment and Children’s Study

    K. Takagi, N. Iwama, H. Metoki, Y. Uchikura, Y. Matsubara, K. Matsubara, H. Nishigori, M. Saito, I. Fujiwara, K. Sakurai, S. Kuriyama, T. Arima, K. Nakai, N. Yaegashi, T. Sugiyama

    Journal of Developmental Origins of Health and Disease　10　(5)　542-554　2019/10

    DOI： 10.1017/s2040174418001162 　

    ISSN： 2040-1744

    eISSN： 2040-1752

  133. 当院における胎盤ポリープの管理方法についての検討

    高橋 新, 只川 真理, 岩間 憲之, 渡邉 善, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　67回　57-57　2019/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  134. 当院における過去5年間の前置癒着胎盤症例の検討

    泉 聖也, 岩間 憲之, 桃野 友太, 只川 真理, 倉片 三千代, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　67回　70-70　2019/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  135. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. International-journal Peer-reviewed

    Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Hypertension research : official journal of the Japanese Society of Hypertension　42　(4)　558-566　2019/04

    DOI： 10.1038/s41440-019-0206-x 　

    ISSN： 0916-9636

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    Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.

  136. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

    Journal of affective disorders　245　475-483　2019/02/15

    DOI： 10.1016/j.jad.2018.11.061 　

    ISSN： 0165-0327

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    BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.

  137. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Hypertension Research　42　(1)　85-94　2019/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41440-018-0124-3 　

    ISSN： 0916-9636

    eISSN： 1348-4214

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    This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.

  138. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

    Journal of hypertension　37　(1)　206-215　2019/01

    DOI： 10.1097/HJH.0000000000001846 　

    ISSN： 0263-6352

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    OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.

  139. Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture. International-journal Peer-reviewed

    Junichi Sugawara, Noriyuki Iwama, Tetsuro Hoshiai, Hideki Tokunaga, Hidekazu Nishigori, Hirohito Metoki, Kunihiro Okamura, Nobuo Yaegashi

    Prehospital and disaster medicine　33　(2)　215-219　2018/04

    DOI： 10.1017/S1049023X18000183 　

    ISSN： 1049-023X

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    OBJECTIVES: This study was aimed to analyze post-disaster birth outcomes in coastal and inland regions of Miyagi Prefecture, Japan. METHODS: Primary data sets were compiled from birth records of obstetric facilities and 12,808 patients were analyzed for baseline birth outcomes by region. Regional risk analysis of the low-birth-weight rate and premature birth rate were conducted using multi-level logistic regression analysis. RESULTS: From overall baseline birth outcomes, a preterm birth rate was 4.6% and low-birth-weight rate was 8.8%. Regional analysis revealed that a preterm birth rate was 3.2% (coastal) and 5.0% (inland), respectively, and the rate of low birth weight was 6.5% in the coastal and 8.5% in the inland region. In the risk analysis of low-birth-weight rate and preterm birth rate, the risk in the coastal region could not be considered any higher than in the inland region (adjusted odds ratio 0.91 [0.73-1.14] and 0.85 [0.46-1.59], respectively). CONCLUSIONS: The incidence of preterm birth and low birth weight were not adversely affected by the disaster. Early transfer and intensive medical intervention may have led to those findings. Further survey will be necessary to determine the long-term effects in both mothers and children. Sugawara J , Iwama N , Hoshiai T , Tokunaga H , Nishigori H , Metoki H , Okamura K , Yaegashi N . Regional birth outcomes after the 2011 Great East Japan Earthquake and tsunami in Miyagi Prefecture. Prehosp Disaster Med. 2018;33(2):215-219.

  140. Maternal body mass index is a better indicator of large-for-gestational-age infants compared with a 75-g oral glucose tolerance test in early pregnancy: The JAGS trial. International-journal Peer-reviewed

    Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Hideto Kusaka, Jota Maki, Hidekazu Nishigori, Nobuo Yaegashi, Norimasa Sagawa, Yuji Hiramatsu, Nagayasu Toyoda

    Diabetes research and clinical practice　132　10-18　2017/10

    DOI： 10.1016/j.diabres.2017.07.017 　

    ISSN： 0168-8227

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    AIMS: There is no previous study comparing the predictive ability of maternal pre-pregnancy body mass index (BMI) versus a 75-g oral glucose tolerance test (OGTT) in early pregnancy for large-for-gestational-age (LGA) infants. METHODS: This multi-institutional prospective cohort study included 966 pregnant Japanese women. A multiple logistic regression model was applied to compare the effect size of pre-pregnancy BMI, fasting plasma glucose (PG), and 1- and 2-h PG levels after a 75-g OGTT performed before 22weeks gestation for LGA. After these variables were included separately into the model as per continuous variables 1 standard deviation (SD) increase, they were included simultaneously. RESULTS: When pre-pregnancy BMI, fasting PG, and 1- and 2-h PG after a 75-g OGTT were separately included in the model, the adjusted odds ratios (ORs) for LGA per 1 SD increase in pre-pregnancy BMI, fasting, and 1- and 2-h PG were 1.55 (95% confidence interval [CI]: 1.26-1.91), 1.26 (95% CI: 1.03-1.54), 0.99 (95% CI: 0.78-1.25), and 1.17 (95% CI: 0.93-1.49), respectively. When these variables were included simultaneously, the adjusted ORs per 1 SD increase in pre-pregnancy BMI, fasting, and 1- and 2-h PG were 1.52 (95% CI: 1.23-1.88), 1.19 (95% CI: 0.96-1.46), 0.77 (95% CI: 0.57-1.03), and 1.30 (95% CI: 0.96-1.76), respectively. CONCLUSIONS: Maternal pre-pregnancy BMI was more strongly associated with LGA compared with a 75-g OGTT in early pregnancy. Health-care providers should recognize that women with a higher pre-pregnancy BMI carry a higher risk for having LGA infants regardless of the results of a 75-g OGTT.

  141. Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

    Disaster medicine and public health preparedness　11　(3)　355-364　2017/06

    DOI： 10.1017/dmp.2016.150 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  142. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

    Disaster medicine and public health preparedness　11　(2)　216-226　2017/04

    DOI： 10.1017/dmp.2016.109 　

    ISSN： 1935-7893

    eISSN： 1938-744X

  143. Monitoring and evaluation of out-of-office blood pressure during pregnancy. International-journal Peer-reviewed

    Hirohito Metoki, Noriyuki Iwama, Mami Ishikuro, Michihiro Satoh, Takahisa Murakami, Hidekazu Nishigori

    Hypertension research : official journal of the Japanese Society of Hypertension　40　(2)　107-109　2017/02

    DOI： 10.1038/hr.2016.112 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  144. Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy. International-journal Peer-reviewed

    Takahiro Sato, Junichi Sugawara, Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa, Nobuo Yaegashi

    PloS one　12　(3)　e0173127　2017

    DOI： 10.1371/journal.pone.0173127 　

    ISSN： 1932-6203

  145. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children's Study. Peer-reviewed

    Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi

    The Tohoku journal of experimental medicine　240　(4)　309-321　2016/12

    DOI： 10.1620/tjem.240.309 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  146. CHORIOANGIOMA COMPLICATED WITH POLYHYDRAMNIOS, HEAVY FOR DATES, AND FETAL HEART FAILURE Peer-reviewed

    Yusaku Kumagai, Hamada Hirotaka, Tadakawa Mari, Iwama Noriyuki, Hoshiai Tetsuro, Saito Masatoshi, Nishigori Hidekazu, Yaegashi Nobuo

    PLACENTA　46　107-107　2016/10

    DOI： 10.1016/j.placenta.2016.08.020 　

    ISSN： 0143-4004

    eISSN： 1532-3102

  147. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study. International-journal Peer-reviewed

    Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

    Diabetes research and clinical practice　120　132-41　2016/10

    DOI： 10.1016/j.diabres.2016.07.020 　

    ISSN： 0168-8227

    eISSN： 1872-8227

  148. Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). Peer-reviewed

    Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

    REPRODUCTIVE SCIENCES　23　186A-186A　2016/03

    ISSN： 1933-7191

    eISSN： 1933-7205

  149. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. International-journal Peer-reviewed

    Noriyuki Iwama, Hirohito Metoki, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Katsuyo Yagihashi, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    Hypertension research : official journal of the Japanese Society of Hypertension　39　(3)　151-7　2016/03

    DOI： 10.1038/hr.2015.108 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  150. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. International-journal Peer-reviewed

    Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

    Journal of affective disorders　190　341-348　2016/01/15

    DOI： 10.1016/j.jad.2015.10.024 　

    ISSN： 0165-0327

    eISSN： 1573-2517

  151. Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. International-journal Peer-reviewed

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Noriyuki Iwama, Mikiko Katagiri, Hidekazu Nishigori, Yoko Narikawa, Katsuyo Yagihashi, Masahiro Kikuya, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    Hypertension research : official journal of the Japanese Society of Hypertension　38　(11)　770-5　2015/11

    DOI： 10.1038/hr.2015.97 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  152. The Change of Ocular Blood Flow Using Laser Speckle Flowgraphy During Pregnancy Peer-reviewed

    Sato Takahiro, Sugawara Junichi, Sugiyama Takashi, Kurosawa Yasuhiro, Iwama Noriyuki, Ooshio Kiyoka, Metoki Hirohito, Kurakata Michiyo, Saito Masatoshi, Nishigori Hidekazu, Yaegashi Nobuo

    REPRODUCTIVE SCIENCES　22　272A　2015/03

    ISSN： 1933-7191

  153. Blood pressure measured in the clinic and at home during pregnancy among nulliparous and multiparous women: the BOSHI study. International-journal Peer-reviewed

    Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Mami Yamamoto, Konomi Akutsu, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Katsuyo Yagihashi, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

    American journal of hypertension　26　(1)　141-8　2013/01

    DOI： 10.1093/ajh/hps002 　

    ISSN： 0895-7061

  154. Daily serial hemodynamic data during pregnancy and seasonal variation: the BOSHI study. International-journal Peer-reviewed

    Hirohito Metoki, Takayoshi Ohkubo, Taku Obara, Konomi Akutsu, Mami Yamamoto, Mami Ishikuro, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Junichi Sugawara, Takuo Hirose, Michihiro Sato, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

    Clinical and experimental hypertension (New York, N.Y. : 1993)　34　(4)　290-6　2012

    DOI： 10.3109/10641963.2012.681086 　

    ISSN： 1064-1963

  155. 胎内診断し得た先天性幽門閉鎖症の一例

    岩間 憲之, 北村 真理, 片桐 未希子, 斎藤 昌利, 佐藤 多代, 室月 淳

    超音波医学　36　(4)　528-528　2009/07

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  156. バゾプレッシンを子宮筋層に局注直後、心停止となった腹腔鏡下子宮筋腫核出術の1例 Peer-reviewed

    岩間 憲之, 北村 真理, 岡村 智佳子, 安井 友春, 五十嵐 司, 渡辺 正, 渡辺 孝紀

    仙台市立病院医学雑誌　28　69-72　2008/06

    Publisher: 仙台市立病院

    ISSN： 0388-8878

  157. 頸管妊娠に対する子宮鏡下治療の経験 MTX全身投与と子宮鏡下治療のcombination Peer-reviewed

    渡辺 正, 只川 真理, 岩間 憲之, 斎藤 純香, 岡村 智佳子, 安井 友春, 五十嵐 司, 渡辺 孝紀

    日本産科婦人科内視鏡学会雑誌　23　(1)　123-129　2007/12

    Publisher: (一社)日本産科婦人科内視鏡学会

    DOI： 10.5180/jsgoe.23.123 　

    ISSN： 1884-9938

Show all ︎Show first 5

Misc. 91

  1. 妊娠糖尿病診断基準の概要

    岩間憲之, 齋藤昌利, 齋藤昌利, 齋藤昌利, 杉山隆

    日本周産期・新生児医学会雑誌(Web)　59　(4)　2024

    ISSN： 2435-4996

  2. アンジオテンシンII受容体拮抗薬投与により羊水過少・新生児腎機能障害・乳児期高血圧を発症した1例

    後藤なつみ, 富田芙弥, 小原拓, 泉聖也, 田上和磨, 餅井規吉, 齊藤裕也, 高橋司, 齋藤翔子, 赤石美穂, 濱田裕貴, 只川真理, 岩間憲之, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  3. 二次性子宮頸管無力症に対するTACの有用性について

    安藤宏輔, 濱田裕貴, 森亘平, 後藤なつみ, 泉聖也, 田上和磨, 餅井規吉, 齊藤裕也, 高橋司, 齋藤翔子, 富田芙弥, 赤石美穂, 只川真理, 岩間憲之, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  4. 母体血清中sFlt-1/PlGF比と超音波断層法による胎児循環パラメーターに関する後ろ向きコホート研究

    森亘平, 森亘平, 濱田裕貴, 後藤なつみ, 泉聖也, 安藤宏輔, 齊藤裕也, 餅井規吉, 高橋司, 齋藤翔子, 富田芙弥, 赤石美穂, 只川真理, 岩間憲之, 齋藤昌利, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  5. 宮城県における未受診妊産婦の現状

    星合哲郎, 星合哲郎, 富田芙弥, 岩間憲之, 濱田裕貴, 工藤さくら, 谷川原真吾, 谷川原真吾, 齋藤昌利, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  6. 妊娠39週,腹痛から母体死亡に至った血管型エーラス・ダンロス症候群疑いの一例

    餅井規吉, 只川真理, 後藤なつみ, 泉聖也, 安藤宏輔, 佐藤壮樹, 齊藤裕也, 高橋司, 齋藤翔子, 富田芙弥, 濱田裕貴, 岩間憲之, 佐藤多代, 鈴木久也, 齋藤昌利, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  7. 産科DICにおける線溶系マーカーと血液製剤投与量に関する後ろ向きコホート研究

    邑本美沙希, 濱田裕貴, 森亘平, 後藤なつみ, 泉聖也, 餅井規吉, 高橋司, 齋藤翔子, 富田芙弥, 只川真理, 岩間憲之, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  8. 妊婦自身の出生体重と早発型および遅発型妊娠高血圧症候群との関連

    田上和磨, 岩間憲之, 濱田裕貴, 富田芙弥, 工藤理永, 熊谷奈津美, 佐藤直人, 泉聖也, 目時弘仁, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  9. 妊娠週数が周産期救急搬送コーディネート時間に与える影響

    工藤さくら, 富田芙弥, 後藤なつみ, 泉聖也, 安藤宏輔, 田上和磨, 齊藤裕也, 高橋司, 齋藤翔子, 赤石美穂, 濱田裕貴, 只川真理, 岩間憲之, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  10. 両親の出生体重は児の出生体重と関連している:子どもの健康と環境に関する全国調査(エコチル調査)より

    富田芙弥, 岩間憲之, 濱田裕貴, 工藤理永, 田上和磨, 熊谷奈津美, 泉聖也, 星合哲郎, 目時弘仁, 目時弘仁, 菅原準一, 菅原準一, 齋藤昌利, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　60　(Suppl.1)　2024

    ISSN： 2435-4996

  11. Tohoku Medical Megabank Project Three-Generation Cohort Study 10-year efforts and perinatal outcomes

    石黒真美, 小原拓, 黒田真帆, 村上慶子, 野田あおい, 篠田元気, 大類真嗣, 岩間憲之, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 寳澤篤, 栗山進一

    DOHad研究(Web)　12　(1)　2024

    ISSN： 2187-2597

  12. 両親の高血圧・糖尿病・脂質異常症の既往と娘の妊娠高血圧症候群

    石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 野田あおい, 野田あおい, 野田あおい, 篠田元気, 岩間憲之, 岩間憲之, 大類真嗣, 大類真嗣, 村上慶子, 菊谷昌浩, 目時弘仁, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

    日本妊娠高血圧学会雑誌　30　2024

    ISSN： 1880-3172

  13. 妊婦自身の出生体重と早産との関連

    工藤理永, 岩間憲之, 岩間憲之, 濱田裕貴, 富田芙弥, 田上和磨, 熊谷奈津美, 佐藤直人, 泉聖也, 櫻井かすみ, 渡邉善, 石黒真美, 石黒真美, 小原拓, 小原拓, 龍田希, 星合哲郎, 目時弘仁, 目時弘仁, 齋藤昌利, 菅原準一, 菅原準一, 栗山進一, 有馬隆弘, 八重樫伸生, 八重樫伸生

    DOHad研究(Web)　12　(3)　2024

    ISSN： 2187-2597

  14. 経腟超音波を併用した腹腔鏡下子宮頸管縫縮術により妊孕性温存が可能となった子宮頸部病変の一例

    橋本栄文, 永井智之, 橋本千明, 重田昌吾, 島田宗昭, 岩間憲之, 齋藤昌利

    日本産科婦人科内視鏡学会学術講演会(Web)　64th　2024

  15. MRIで指摘し得た早期の常位胎盤早期剥離の一例

    影山咲子, 岩間憲之, 富田芙弥, 齋藤昌利, 高瀬圭

    Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM)　25th　2024

  16. Trends in self-measured blood pressure and indices derived from the blood pressure measurements during pregnancy and postpartum: the BOSHI study

    泉聖也, 岩間憲之, 岩間憲之, 小原拓, 小原拓, 小原拓, 石黒真美, 石黒真美, 村上任尚, 村上任尚, 佐藤倫広, 佐藤倫広, 廣瀬卓男, 大久保孝義, 今井潤, 目時弘仁, 目時弘仁

    日本高血圧学会総会プログラム・抄録集(CD-ROM)　46th　2024

  17. 妊娠前半期に診断された妊娠糖尿病における周産期予後不良アウトカムの危険因子

    岩間憲之, 横山真紀, 山下洋, 宮越敬, 安日一郎, 川崎麻紀, 荒田尚子, 佐藤志織, 飯村祐子, 和栗雅子, 川口晴菜, 正岡直樹, 中島義之, 平松祐司, 杉山隆

    糖尿病と妊娠　24　(3)　2024

    ISSN： 1347-9172

  18. 分娩後に劇症型A群レンサ球菌感染症による血栓性微小血管症(TMA)を合併した一例

    金銅妃奈子, 岡本好司, 秋保真穂, 濱田裕貴, 只川まり, 岩間憲之, 齋藤昌利, 田中哲洋, 宮崎真理子

    日本腎臓学会誌(Web)　66　(6-E)　2024

    ISSN： 1884-0728

  19. 血管型Ehlers-Danlos症候群合併妊娠の周産期管理:症例報告と文献的レビュー

    熊谷奈津美, 富田芙弥, 星合哲郎, 岩間憲之, 只川真理, 濱田裕貴, 齋藤翔子, 秋山志津子, 埴田卓志, 小原拓, 谷垣伸治, 谷垣伸治, 古庄知己, 古庄知己, 青木洋子, 齋藤昌利

    周産期医学　54　(11)　2024

    ISSN： 0386-9881

  20. sFlt-1/PlGF比は前置胎盤における分娩前大量性器出血予測に有用となるか?

    森亘平, 濱田裕貴, 泉聖也, 安藤宏輔, 齊藤裕也, 餅井規吉, 高橋司, 齋藤翔子, 富田芙弥, 只川真理, 岩間憲之, 齋藤昌利, 齋藤昌利

    日本母体胎児医学会学術集会プログラム・抄録集　46th　2024

  21. 母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連 三世代コホート調査

    高橋 一平, 小原 拓, 菊地 紗耶, 小林 美佳, 石黒 真美, 村上 慶子, 上野 史彦, 野田 あおい, 大沼 ともみ, 松崎 芙実子, 小林 奈津子, 濱田 裕貴, 岩間 憲之, 齋藤 昌利, 菅原 準一, 富田 博秋, 呉 繁夫, 八重樫 伸生, 栗山 進一

    DOHaD研究　11　(3)　29-29　2023/08

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  22. 妊娠糖尿病に関する周産期予後と管理のエビデンスについて—特集 妊娠糖尿病・糖尿病合併妊娠の管理

    岩間 憲之, 齋藤 昌利, 杉山 隆

    糖尿病　15　(2)　6-10　2023/02

    Publisher: 東京 : 医学出版

  23. 妊娠糖尿病診断基準の概要

    岩間憲之, 齋藤昌利, 杉山隆

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  24. コロナ禍における妊娠糖尿病診断の変化に関する全国調査による検討

    春日義史, 春日義史, 宮越敬, 宮越敬, 横山真紀, 横山真紀, 中西沙由理, 中西沙由理, 岩間憲之, 岩間憲之, 杉山隆, 杉山隆

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  25. 最近5年間の当院における産後出血搬送症例の検討

    富田芙弥, 工藤理永, 熊谷奈津美, 高橋新, 齋藤翔子, 熊谷祐作, 岩間憲之, 只川真理, 星合哲郎, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  26. 妊娠中に捻転を来したparasitic myomaの一例

    高橋新, 星合哲郎, 熊谷奈津美, 齋藤翔子, 熊谷祐作, 富田芙弥, 只川真理, 岩間憲之, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  27. 血管型Ehlers-Danlos syndrome合併妊娠の一例

    熊谷奈津美, 富田芙弥, 星合哲郎, 岩間憲之, 只川真理, 熊谷祐作, 齋藤翔子, 高橋新, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  28. 人工妊娠中絶前後に発熱・肝機能障害・血球減少・尿閉を呈したHSV感染症(Elsberg症候群)の一例

    齋藤翔子, 齋藤昌利, 只川真理, 岩間憲之, 富田芙弥, 熊谷祐作, 餅井規吉, 熊谷奈津美, 佐藤壮樹, 高橋新

    日本周産期・新生児医学会雑誌(Web)　59　(Suppl.1)　2023

    ISSN： 2435-4996

  29. The diagnosis of gestational diabetes during COVID-19 pandemic in Japan

    春日義史, 宮越敬, 横山真紀, 中西沙由理, 岩間憲之, 市川雷師, 安孫子亜津子, 原島伸一, 杉山隆

    糖尿病と妊娠　23　(2)　2023

    ISSN： 1347-9172

  30. 妊娠後期に低カリウム性周期性四肢麻痺を発症し妊娠時一過性甲状腺機能亢進症の関与が疑われた1例

    矢浦一磨, 久保晴丸, 相良いづみ, 手塚雄太, 尾股慧, 小野美澄, 岩間憲之, 片桐秀樹

    日本甲状腺学会学術集会プログラム・抄録集(Web)　66th　2023

  31. MRIが診断の契機となった間葉性異形成胎盤(placental mesenchymal dysplasia,PMD)の一例

    臼崎琢磨, 佐藤友美, 影山咲子, 岩間憲之

    Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM)　24th　2023

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    日本医療薬学会年会講演要旨集(Web)　33rd　2023

    ISSN： 2424-2470

  33. 出生コホート連携における年齢別の不妊治療と妊娠高血圧症候群との関連

    石黒真美, 小原拓, 西村倫子, 岩田啓芳, 目時弘仁, 岩間憲之, 村上慶子, RAHMAN Shafiur, 小林澄貴, 宮下ちひろ, 石塚一枝, 田中景子, 三宅吉博, 堀川玲子, 森崎菜穂, 土屋賢治, 岸玲子, 栗山進一

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  34. 母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連 三世代コホート調査

    高橋一平, 小原拓, 小原拓, 小原拓, 菊地紗耶, 菊地紗耶, 小林美佳, 小林美佳, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大沼ともみ, 松崎芙実子, 松崎芙実子, 小林奈津子, 小林奈津子, 濱田裕貴, 濱田裕貴, 岩間憲之, 岩間憲之, 齋藤昌利, 齋藤昌利, 菅原準一, 菅原準一, 富田博秋, 富田博秋, 富田博秋, 富田博秋, 呉繋夫, 呉繋夫, 八重樫伸生, 八重樫伸生, 八重樫伸生, 栗山進一, 栗山進一, 栗山進一

    DOHad研究(Web)　11　(3)　2023

    ISSN： 2187-2597

  35. TERATOGENIC RISK OF FIRST TRIMESTER EXPOSURE TO ANTIHYPERTENSIVES, INCLUDING AMLODIPINE AND METHYLDOPA: AN ANALYSIS OF AN ADMINISTRATIVE DATABASE 2010-2019

    Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

    JOURNAL OF HYPERTENSION　41　E422-E422　2023/01

    ISSN： 0263-6352

    eISSN： 1473-5598

  36. 魚の摂取頻度と月経痛の有病率の長期的検討 エコチル調査における宮城ユニットセンター追加調査

    横山 絵美, 武田 卓, 渡邉 善, 岩間 憲之, 佐藤 倫広, 村上 任尚, 櫻井 香澄, 志賀 尚美, 龍田 希, 齋藤 昌利, 立花 眞仁, 有馬 隆博, 栗山 進一, 目時 弘仁, 八重樫 伸生

    日本女性医学学会雑誌　30　(1)　125-125　2022/10

    Publisher: (一社)日本女性医学学会

    ISSN： 2185-8861

  37. 妊娠初期の胎児後頸部浮腫と周産期予後に関する後ろ向きコホート研究

    齋藤翔子, 志賀尚美, 工藤理永, 熊谷奈津美, 高橋新, 宮副美奈子, 遠藤俊, 桃野友太, 熊谷祐作, 富田芙弥, 濱田裕貴, 石橋ますみ, 只川真理, 岩間憲之, 星合哲郎, 齋藤昌利

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集(Web)　151st　2022

  38. 婦人科悪性腫瘍における直接経口抗凝固薬の使用下での静脈血栓塞栓症再発または抗凝固薬変更の予測モデル

    清水孝規, 岩間憲之, 徳永英樹, 遠藤俊, 宮原周子, 土岐麻実, 志賀尚美, 石橋ますみ, 重田昌吾, 永井智之, 島田宗昭, 八重樫伸生

    日本産科婦人科学会雑誌　74　2022

    ISSN： 0300-9165

  39. 卵管間質部妊娠術後妊娠と子宮破裂-当施設における症例集積研究と系統的文献レビュー-

    成重さつき, 濱田裕貴, 富田芙弥, 熊谷祐作, 只川真理, 岩間憲之, 星合哲郎, 齋藤昌利, 八重樫伸生

    産婦人科の実際　71　(5)　2022

    ISSN： 0558-4728

  40. 妊娠期乳がんに対する治療介入時期と新生児予後の症例集積検討

    遠藤俊, 濱田裕貴, 岩間憲之, 星合哲郎, 齋藤昌利, 八重樫伸生

    日本周産期・新生児医学会雑誌(Web)　57　(Suppl)　2021

    ISSN： 2435-4996

  41. 当院における広汎子宮頸部全摘術後妊娠に対する周産期管理の検討

    鈴木真理, 濱田裕貴, 岩間憲之, 星合哲郎, 齋藤昌利, 八重樫伸生

    日本周産期・新生児医学会雑誌(Web)　57　(Suppl)　2021

    ISSN： 2435-4996

  42. 当院における臍帯卵膜付着症例を対象とした症例集積研究

    齋藤翔子, 岩間憲之, 齋藤裕也, 熊谷祐作, 森部絢子, 富田芙弥, 齋藤彰治, 濱田裕貴, 只川真理, 大塩清佳, 星合哲郎, 齋藤昌利

    日本周産期・新生児医学会雑誌(Web)　57　(Suppl)　2021

    ISSN： 2435-4996

  43. 卵管間質部妊娠術後妊娠の子宮破裂に関する検討:当施設における後方視的検討と系統的文献レビュー

    濱田裕貴, 佐藤直人, 齊藤裕也, 森部絢子, 富田芙弥, 齋藤彰治, 只川真理, 岩間憲之, 大塩清佳, 星合哲郎, 齋藤昌利, 八重樫伸生

    日本周産期・新生児医学会雑誌(Web)　57　(Suppl)　2021

    ISSN： 2435-4996

  44. 妊娠期乳癌に対する治療介入時期と新生児予後の症例集積検討

    後藤なつみ, 濱田裕貴, 齋藤裕也, 遠藤俊, 熊谷祐作, 森部絢子, 富田芙弥, 只川真理, 岩間憲之, 大塩清佳, 星合哲郎, 八重樫伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集(Web)　68th　2021

  45. 広汎子宮頸部摘出術後妊娠に対する上行性感染予防の症例集積検討

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    北日本産科婦人科学会総会・学術講演会プログラム・抄録集(Web)　68th　2021

  46. 宮城県における未受診妊婦・飛び込み分娩に関する検討~児童虐待予防の新たな対策~

    星合哲郎, 齋藤昌利, 岩間憲之, 濱田裕貴, 八重樫伸生, 埴田卓志, 浜崎洋一, 谷川原真吾, 崔佳苗実

    日本周産期・新生児医学会雑誌(Web)　56　(Suppl.2)　2020

    ISSN： 2435-4996

  47. 双胎妊娠と単胎妊娠における妊娠中母体血圧の比較 エコチル調査

    岩間 憲之, 目時 弘仁, 西郡 秀和, 田中 宏典, 斎藤 昌利, 杉山 隆, 八重樫 伸生

    日本周産期・新生児医学会雑誌　55　(2)　634-634　2019/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

  48. 妊娠中の喫煙と妊娠高血圧症候群 エコチル調査より

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    日本周産期・新生児医学会雑誌　55　(2)　663-663　2019/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  49. 妊娠中に発症したスキーン腺嚢胞の一例

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    日本周産期・新生児医学会雑誌　55　(2)　656-656　2019/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  50. 妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

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    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  51. 妊婦の推定糸球体ろ過量(eGFR)と妊娠高血圧症候群の関連について BOSHI研究

    菊地 ひかり, 奈良井 大輝, 佐々木 里美, 高畠 恭介, 中山 晋吾, 佐藤 倫広, 村上 任尚, 岩間 憲之, 石黒 真美, 小原 拓, 大久保 孝義, 今井 潤, 目時 弘仁

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　8回　198-198　2019/05

    Publisher: (NPO)日本高血圧学会

  52. 妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

    岩間 憲之, 田中 宏典, 目時 弘仁, 西郡 秀和, 水野 聖士, 高橋 史郎, 渡邉 善, 齋藤 昌利, 櫻井 香澄, 石黒 真美, 小原 拓, 龍田 希, 西島 維知子, 杉山 隆, 藤原 幾磨, 栗山 進一, 有馬 隆博, 仲井 邦彦, 八重樫 伸生

    日本妊娠高血圧学会雑誌　25　109-109　2018/11

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  53. 生児を得た子宮動静脈奇形合併妊娠の1例

    熊谷 祐作, 齋藤 昌利, 富田 芙弥, 黒澤 靖大, 只川 真理, 岩間 憲之, 倉片 三千代, 星合 哲郎, 西郡 秀和, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　66回　0093-0093　2018/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  54. 腹腔鏡下手術を行った成熟嚢胞性奇形腫合併卵巣カルチノイド腫瘍の1例

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    日本産科婦人科内視鏡学会雑誌　34　(Supplement 1)　247　2018/08

    ISSN： 1884-9938

  55. 卵管から発生した成熟奇形腫の1例

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    産婦人科の実際　67　(5)　581‐584-584　2018/05/01

    Publisher: 金原出版(株)

    DOI： 10.18888/sp.0000000444 　

    ISSN： 0558-4728

  56. 羊水過多を合併した胎盤血管腫 胎児心不全を予測した1例

    熊谷 祐作, 濱田 裕貴, 只川 真理, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 西郡 秀和, 八重樫 伸生

    北海道産科婦人科学会会誌　62　(1)　185-185　2018/03

    Publisher: 北海道産科婦人科学会

    ISSN： 0367-6277

  57. 産褥初期に発熱を主訴に来院し、肺結核と診断された1例

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    北海道産科婦人科学会会誌　62　(1)　219-219　2018/03

    Publisher: 北海道産科婦人科学会

    ISSN： 0367-6277

  58. 産道出血の血管塞栓術後に側副血行路の塞栓を要した1例

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    Japanese Journal of Radiology　36　(Supplement)　1-1　2018/02/25

    Publisher: (公社)日本医学放射線学会

    ISSN： 1867-1071

    eISSN： 1867-108X

  59. 帝王切開瘢痕部妊娠の1例

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    大崎市民病院誌　21　(1)　60‐63　2017/12/18

    ISSN： 1881-6142

  60. 羊水過多、Heavy for Dates、胎児心不全を合併した胎盤血管腫

    熊谷 祐作, 濱田 裕貴, 岩間 憲之, 佐藤 直実, 星合 哲郎, 斎藤 昌利, 西郡 秀和, 菅原 準一, 八重樫 伸生

    日本妊娠高血圧学会雑誌　24　104-104　2017/09

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  61. 卵管から発生した成熟奇形腫の1例

    白井友梨, 齋藤淳一, 鏡友理絵, 宮野菊子, 熊谷祐作, 岩間憲之, 松本大樹, 我妻理重

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集(Web)　143rd　ROMBUNNO.49 (WEB ONLY)-80　2017

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  62. 妊娠中の高血圧

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    日本高血圧学会総会プログラム・抄録集　39th　237　2016/09/30

  63. 羊水過多を合併した胎盤血管腫 胎児心不全を予測した1例

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    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　64回　104-104　2016/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  64. 産褥初期に発熱を主訴に来院し、肺結核と診断された一例

    圓山 晶子, 西堀 翔子, 濱田 裕貴, 只川 真理, 岩間 憲之, 星合 哲郎, 齋藤 昌利, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　64回　145-145　2016/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  65. 妊娠24週未満に施行した75gブドウ糖負荷試験および妊娠前BMIとHFDとの関連 JAGS trialを用いた検討

    岩間 憲之, 八重樫 伸生, 杉山 隆

    糖尿病と妊娠　16　(2)　140-141　2016/08

    Publisher: (一社)日本糖尿病・妊娠学会

    ISSN： 1347-9172

  66. 帝王切開創に広範な裂創を生じたOHVIRA症候群治療後妊娠の1例

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    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集　141回　74-74　2016/06

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  67. 宮城県における飛び込み分娩の医学的・社会的リスク因子

    濱田 裕貴, 西堀 翔子, 田中 宏典, 高橋 聡太, 岩間 憲之, 大塩 清佳, 倉片 三千代, 星合 哲郎, 齋藤 昌利, 西郡 秀和, 菅原 準一, 八重樫 伸生

    日本周産期・新生児医学会雑誌　52　(2)　535-535　2016/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  68. 妊娠37週に子宮脱を発症し帝王切開にて分娩に至った一症例

    西堀 翔子, 齋藤 昌利, 高橋 聡太, 濱田 裕貴, 岩間 憲之, 大塩 清佳, 星合 哲郎, 西郡 秀和, 八重樫 伸生

    日本周産期・新生児医学会雑誌　52　(2)　725-725　2016/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  69. 同胞間で異なる転帰を辿った、1絨毛膜2羊膜双胎妊娠における超早産症例

    高橋 聡太, 齋藤 昌利, 西堀 翔子, 濱田 裕貴, 岩間 憲之, 近藤 亜希子, 大塩 清佳, 倉片 三千代, 星合 哲郎, 西郡 秀和, 菅原 準一, 木村 芳孝, 八重樫 伸生

    日本周産期・新生児医学会雑誌　52　(2)　746-746　2016/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  70. 羊水過多,Heavy for Dates,胎児心不全を合併した胎盤血管腫

    熊谷祐作, 濱田裕貴, 只川真理, 岩間憲之, 星合哲郎, 斎藤昌利, 西郡秀和, 八重樫伸生

    日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集　34th-24th　103　2016

  71. 妊娠24週未満に施行した75gブドウ糖負荷試験および妊娠前BMIとHFDとの関連 JAGS trialを用いた検討

    岩間 憲之, 八重樫 伸生, 杉山 隆, Japan Assessment of GDM Screening Group

    糖尿病と妊娠　15　(2)　S-45　2015/10

    Publisher: (一社)日本糖尿病・妊娠学会

    ISSN： 1347-9172

  72. ダナゾール内服治療が有効であった子宮動静脈奇形の1例

    西堀 翔子, 岩間 憲之, 平山 亜由子, 齋藤 昌利, 杉山 隆, 八重樫 伸生

    北日本産科婦人科学会総会・学術講演会プログラム・抄録集　63回　120-120　2015/09

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  73. レーザースペックルフローグラフィーを用いた妊娠中の新規非侵襲的眼底網膜血流評価

    佐藤 孝洋, 菅原 準一, 岩間 憲之, 大塩 清佳, 倉片 三千代, 齋藤 昌利, 目時 弘仁, 西郡 秀和, 杉山 隆, 八重樫 伸生

    日本周産期・新生児医学会雑誌　51　(2)　693-693　2015/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  74. Discordant DD-twinsの原因が軟骨異栄養症と臍帯胎盤因子によると考えられた一例

    佐々木 恵, 杉山 隆, 黒澤 靖大, 岩間 憲之, 大塩 清佳, 倉片 三千代, 齋藤 昌利, 八重樫 伸生

    東北連合産科婦人科学会総会・学術講演会プログラム・抄録集　139回　66-66　2015/06

    Publisher: 東北連合産科婦人科学会・北日本産科婦人科学会

  75. Blood Pressure and Heart Rate Among Pregnant Women Before and After the Great East Japan Earthquake (11, March, 2011) in the BOSHI Study. Peer-reviewed

    Metoki Hirohito, Iwama Noriyuki, Watanabe Zen, Ohkubo Takayoshi, Ishikuro Mami, Obara Taku, Kikuya Masahiro, Sugawara Junichi, Kuriyama Shinichi, Itoh Kiyoshi, Hoshi Kazuhiko, Suzuki Masakuni, Satoh Michihiro, Yaegashi Nobuo, Imai Yutaka

    REPRODUCTIVE SCIENCES　22　385A　2015/03

    ISSN： 1933-7191

  76. Home Blood Pressure Had a Stronger Predictive Power for Infant Birth Weight Than Clinic Blood Pressure: The Boshi Study. Peer-reviewed

    Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, Ishikuro Mami, Obara Taku, Kikuya Masahiro, Yagihashi Katsuyo, Nishigori Hidekazu, Sugiyama Takashi, Sugawara Junichi, Yaegashi Nobuo, Hoshi Kazuhiko, Suzuki Masakuni, Kuriyama Shinichi, Imai Yutaka

    REPRODUCTIVE SCIENCES　22　383A　2015/03

    ISSN： 1933-7191

  77. 非侵襲的眼底血流測定装置レーザースペックルフローグラフィーを用いた妊娠中の新規眼底網膜血流評価法

    佐藤 孝洋, 菅原 準一, 杉山 隆, 黒澤 靖大, 岩間 憲之, 大塩 清佳, 目時 弘仁, 倉片 三千代, 齋藤 昌利, 西郡 秀和, 八重樫 伸生

    日本産科婦人科学会雑誌　67　(2)　591-591　2015/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  78. 妊娠中の家庭血圧は外来血圧より強く児の出生体重と関連していた BOSHI研究

    岩間 憲之, 目時 弘仁, 西郡 秀和, 杉山 隆, 菅原 準一, 八重樫 伸生, 星 和彦, 鈴木 雅洲

    日本産科婦人科学会雑誌　67　(2)　593-593　2015/02

    Publisher: (公社)日本産科婦人科学会

    ISSN： 0300-9165

  79. P3-40-5 東日本大震災前後の妊婦の血圧と心拍の変化(Group142 妊娠高血圧症候群4,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    目時 弘仁, 岩間 憲之, 渡邉 善, 西郡 秀和, 菅原 準一, 伊藤 潔, 星 和彦, 鈴木 雅洲, 八重樫 伸生

    日本産科婦人科學會雜誌　67　(2)　923-923　2015

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  80. P1-40-3 宮城県における飛び込み分娩の医学的・社会的リスク因子と東日本大震災が与えた影響(Group40 周産期問題への地域の取り組み,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    濱田 裕貴, 岩間 憲之, 黒澤 靖大, 倉片 三千代, 齋藤 昌利, 西郡 秀和, 杉山 隆, 菅原 準一, 八重樫 伸生

    日本産科婦人科學會雜誌　67　(2)　640-640　2015

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  81. P1-32-8 肥満の有無が妊娠糖尿病の妊娠合併症に及ぼす影響(Group32 合併症妊娠3,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

    氷室 裕美, 杉山 隆, 岩間 憲之, 目時 弘仁, 大塩 清佳, 倉片 三千代, 齋藤 昌利, 西郡 秀和, 菅原 準一, 八重樫 伸生

    日本産科婦人科學會雜誌　67　(2)　618-618　2015

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  82. エコチル調査・宮城ユニットセンターにおける妊婦の医薬品使用状況の評価-宮城ユニットセンター薬剤詳細調査より-

    西郡 秀和, 小原 拓, 目時 弘仁, 石黒 真美, 水野 聖士, 櫻井 香澄, 岩間 憲之, 村井 ユリ子, 杉山 隆, 菅原 準一, 眞野 成康, 栗山 進一, 八重樫 伸生

    DOHaD研究　3　(1)　49-49　2014

    Publisher: 日本DOHaD研究会

    ISSN： 2187-2597

    More details Close

    第3回日本DOHaD研究会学術集会 抄録集 【ポスター発表】

  83. 妊娠期間中の家庭血圧は正常であったが急速に妊娠高血圧腎症・子癇発作を発症した1例

    目時 弘仁, 渋谷 祐介, 岩間 憲之, 片桐 未希子, 小原 拓, 菊谷 昌浩, 大久保 孝義, 西郡 秀和, 佐藤 尚明, 田中 耕平, 星 和彦, 鈴木 雅洲, 今井 潤, 菅原 準一, 八重樫 伸生

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　2回　152-152　2013/05

    Publisher: (NPO)日本高血圧学会

  84. 【急速遂娩の基本-トラブルを避けるために】 急速遂娩の判断基準 胎児心拍数図波形の異常

    岩間 憲之, 菅原 準一

    臨床婦人科産科　67　(2)　220-229　2013/03

    Publisher: (株)医学書院

    ISSN： 0386-9865

  85. K2-7-6 妊娠糖尿病1点異常に対する管理に関する後方視的研究:JGSG study(高得点演題12 周産期医学3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

    杉山 隆, 目時 弘仁, 岩間 憲之, 菅原 準一, 八重樫 伸生, 森川 守, 水上 尚典, 板倉 敦夫, 吉田 純, 竹田 善治, 中林 正雄, 宮越 敬, 吉村 泰典, 竹田 省, 牧野 康男, 松田 義雄, 小川 浩平, 荒田 尚子, 左合 治彦, 永石 匡司, 山本 樹生, 正岡 直樹, 田中 守, 奥田 美加, 高橋 恒男, 牧野田 知, 神元 有紀, 池田 智明, 日下 秀人, 光田 信明, 成瀬 勝彦, 小林 浩, 増山 寿, 平松 祐司, 寺本 秀樹, 前田 和寿, 苛原 稔, 阿部 恵美子, 洲脇 尚子, 山下 洋, 安日 一郎, 上妻 友隆, 堀 大蔵, 鮫島 浩, 上塘 正人, 佐川 典正

    日本産科婦人科學會雜誌　65　(2)　694-694　2013

    Publisher: 日本産科婦人科学会

    ISSN： 0300-9165

  86. 初産婦・経産婦における妊娠中の外来血圧及び家庭血圧推移 BOSHI研究

    石黒 真美, 小原 拓, 目時 弘仁, 大久保 孝義, 山本 真実, 阿久津 好美, 櫻井 香澄, 岩間 憲之, 片桐 未希子, 八木橋 香津代, 鈴木 雅洲, 八重樫 伸生, 栗山 進一, 今井 潤

    日本妊娠高血圧学会雑誌　19　99-100　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  87. 妊娠初期の食塩摂取量と妊娠高血圧症候群発症との関連 BOSHI研究

    山本 真実, 小原 拓, 目時 弘仁, 大久保 孝義, 石黒 真美, 阿久津 好美, 櫻井 香澄, 片桐 未希子, 岩間 憲之, 八木橋 香津, 鈴木 雅洲, 栗山 進一, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　19　202-203　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  88. PIHと脳血管障害をめぐる諸問題 24時間自由行動下血圧・家庭血圧と脳血管障害

    目時 弘仁, 大久保 孝義, 小原 拓, 阿久津 好美, 山本 真実, 石黒 真美, 櫻井 香澄, 岩間 憲之, 片桐 未希子, 菊谷 昌浩, 八木橋 香津代, 森 滋, 鈴木 雅洲, 栗山 進一, 八重樫 伸生, 今井 潤

    日本妊娠高血圧学会雑誌　19　49-53　2012/01

    Publisher: 日本妊娠高血圧学会

    ISSN： 1880-3172

  89. 妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連 BOSHI研究

    目時 弘仁, 星川 美奈子, 大久保 孝義, 阿久津 好美, 小原 拓, 櫻井 香澄, 片桐 未希子, 岩間 憲之, 八木橋 香津代, 森 滋, 鈴木 雅洲, 栗山 進一, 松原 洋一, 八重樫 伸生, 今井 潤

    日本高血圧学会総会プログラム・抄録集　34回　437-437　2011/10

    Publisher: (NPO)日本高血圧学会

  90. 胎児超音波により肺葉外肺分画症と診断できた一例

    北村 真理, 岩間 憲之, 片桐 未希子, 松田 雪香, 齋藤 昌利, 今井 紀昭, 佐藤 多代, 高野 忠夫, 室月 淳, 岡村 州博

    超音波医学　36　(4)　528-528　2009/07

    Publisher: (公社)日本超音波医学会

    ISSN： 1346-1176

    eISSN： 1881-9311

  91. 当院における飛び込み分娩症例の検討

    北村 真理, 岩間 憲之, 岡村 智佳子, 安井 友春, 五十嵐 司, 渡辺 正, 渡辺 孝紀

    仙台市立病院医学雑誌　28　15-19　2008/06

    Publisher: 仙台市立病院

    ISSN： 0388-8878

Show all ︎Show first 5

Research Projects 2

  1. Comprehensive Omics Profiling of Placenta Previa Utilizing Biobank Resources for Clinical Translation

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2025/04/01 - 2029/03/31

  2. 遺伝環境要因と児の出生体重に関する研究

    岩間 憲之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    Category: 若手研究

    Institution: 東北大学

    2019/04/01 - 2023/03/31

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    三世代コホート調査データを使用したSmall for gestational age（SGA）児の予測モデルに関して、英語論文を執筆した（現時点で国際誌に投稿中である）。17,073組の妊婦とその児を解析対象とした。妊娠初期（妊娠11週0日～妊娠17週6日）、妊娠中期（妊娠18週0日～妊娠21週6日）それぞれにおいて、多重ロジスティック回帰分析でSGA児を予測するリスクスコアを作成した。児の出生体重が10パーセンタイル未満の場合にSGA児と定義した。解析の結果、妊娠初期リスクスコアで選択された変数は、妊婦の年齢、身長、妊娠初期のbody mass index (BMI)、分娩歴、生殖補助医療技術、妊婦の出生体重、喫煙、妊娠初期の高血圧であった。また、妊娠中期リスクスコアで選択された変数は、妊婦の年齢、身長、妊娠中期のBMI、妊娠中の体重増加、分娩歴、生殖補助医療技術、妊婦の出生体重、喫煙、妊娠中期の高血圧、妊娠中期の胎児推定体重であった。妊娠初期と中期リスクスコアのC統計量は、それぞれ0.658 (95% confidence interval[CI]: 0.642-0.675)、0.725 (95% CI: 0.710-0.738)であり、10分割交差検証でのC統計量は、それぞれ0.659 (95% CI: 0.642-0.676)、0.726 (95% CI: 0.710-0.741)であった。妊娠中期リスクスコアのC統計量は、妊娠初期リスクスコアと比較して有意に高かった。 さらに、SGA児の予測モデルを社会実装するため、論文執筆内容を元にアプリ作成に貢献している（https://pesga.topic-tommo.net/sga1_select）。これはSGA児を予測するための変数をWeb上で入力し、SGA児を分娩する予測確率を自動的に計算するものである。現時点では、SGA児の予測確率が計算される段階まで完成している。

Works 2

  1. The BOSHI study

    2012/04 -

  2. The Japan Birth Cohort Consortium