Details of the Researcher

PHOTO

Hitomi Anzai
Section
Institute of Fluid Science
Job title
Associate Professor
Degree

  • 博士（工学）（東北大学）

  • 修士（工学）（東北大学）

Committee Memberships 1

  • 日本機械学会 バイオエンジニアリング部門 若手による次世代戦略委員会　若手による次世代戦略委員会 委員

    2021/04 - Present

Professional Memberships 2

  • JAPANESE SOCIETY OF BIORHEOLOGY

  • THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

Research Interests 3

  • Structual Optimization

  • Intracranial aneurysm

  • Computational Fluid Dynamics

Research Areas 1

  • Life sciences / Biomedical engineering /

Awards 3

  1. Poster Award

    2016/11/27　13th International IntraCranial Stent Meeting　Correlating MR Wall Enhancement and Wall Shear Stress: Does CFD work to predict aneurysm instability?

  2. Poster Award

    2016/11/27　13th International IntraCranial Stent Meeting　Exploring the relationship between the inflow zone and strut positions within the aneurysm orifice: a hemodynamic simulation study

  3. Outstanding Award for Poster

    2010/11/03　Seventh international Conference on Flow Dynamics

Papers 102

  1. Physics-informed neural networks for three-dimensional cerebrovascular hemodynamic prediction: A point cloud preprocessing strategy based on limited data

    Jing Liao, Gaoyang Li, Keito Yanagisawa, Shin-Ichiro Sugiyama, Makoto Ohta, Hitomi Anzai

    Engineering Applications of Artificial Intelligence　2025/11

    DOI： 10.1016/j.engappai.2025.112034 　

  2. Effects of wall compliance on pulsatile flow in a full-scale, patient-specific cerebral aneurysm model: Particle image velocimetry experiments

    Ryuhei Yamaguchi, Muhamed Albadawi, Nadia Shaira Shafii, Atsushi Saito, Toshiyuki Nakata, Khalid M. Saqr, Hitomi Anzai, Makoto Ohta

    Medical Engineering & Physics　2025/08

    DOI： 10.1016/j.medengphy.2025.104381 　

  3. Effect of airway geometry and maximum number of generations on droplet generation during coughing

    Naoki Kobayashi, Makoto Ohta, Hitomi Anzai

    Physics of Fluids　2025/06/01

    DOI： 10.1063/5.0271958 　

  4. The influence of blood velocity and vessel geometric parameters on wall shear stress

    Fangjia Pan, Naoko Mori, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    Medical Engineering & Physics　2024/02

    DOI： 10.1016/j.medengphy.2024.104112 　

  5. Exploring the Variations in Angles Around Basilar Bifurcation Categorized by Aneurysm Locations Peer-reviewed

    Fangjia Pan, Philippe Bijlenga, Naoko Mori, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    2023 15th Biomedical Engineering International Conference (BMEiCON)　1-5　2023/10/28

    Publisher: IEEE

    DOI： 10.1109/bmeicon60347.2023.10322063 　

  6. Physics-informed neural networks (PINNs) for 4D hemodynamics prediction: An investigation of optimal framework based on vascular morphology

    Xuelan Zhang, Baoyan Mao, Yue Che, Jiaheng Kang, Mingyao Luo, Aike Qiao, Youjun Liu, Hitomi Anzai, Makoto Ohta, Yuting Guo, Gaoyang Li

    Computers in Biology and Medicine　2023/09

    DOI： 10.1016/j.compbiomed.2023.107287 　

  7. Generalized versus Specific Boundary Conditions for CFD in vertebral-basilar artery Peer-reviewed

    Fangjia Pan, Naoko Mori, Shunji Mugikura, Philippe Bijlenga, Makoto Ohta, Hitomi Anzai

    2023 8th International Conference on Instrumentation, Control, and Automation (ICA)　19-24　2023/08/09

    Publisher: IEEE

    DOI： 10.1109/ica58538.2023.10273076 　

  8. Elongation of the proximal descending thoracic aorta and associated hemodynamics increase the risk of acute type B aortic dissection. International-journal

    Xuelan Zhang, Yuan Peng, Gaoyang Li, Jiehua Li, Mingyao Luo, Yue Che, Liancun Zheng, Hitomi Anzai, Makoto Ohta, Chang Shu

    Technology and health care : official journal of the European Society for Engineering and Medicine　2023/08/03

    DOI： 10.3233/THC-230194 　

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    BACKGROUND: Acute type B aortic dissection (ATBAD) is a life-threatening aortic disease. However, little information is available on predicting and understanding of ATBAD. OBJECTIVE: The study sought to explore the underlying mechanism of ATBAD by analyzing the morphological and hemodynamic characteristics related to aortic length. METHODS: The length and tortuosity of the segment and the whole aorta in the ATBAD group (n= 163) and control group (n= 120) were measured. A fixed anatomic landmark from the distal of left subclavian artery (LSA) to the superior border of sixth thoracic vertebra was proposed as the proximal descending thoracic aorta (PDTA), and the dimensionless parameter, length ratio, was introduced to eliminate the individual differences. The significant morphological parameters were filtrated and the associations between parameters were investigated using statistical approaches. Furthermore, how aortic morphology influenced ATBAD was explored based on idealized aortic models and hemodynamic-related metrics. RESULTS: The PDTA length was significantly increased in the ATBAD group compared with the control group and had a strong positive correlation with the whole aortic length (r= 0.89). The length ratio (LR2) and tortuosity (T2) of PDTA in the ATBAD group were significantly increased (0.15 ± 0.02 vs 0.12 ± 0.02 and 1.73 ± 0.48 vs 1.50 ± 0.36; P< 0.001), and LR2 was positive correlation with T2 (r= 0.73). In receiver-operating curve analysis, the area under the curve was 0.835 for LR2 and 0.641 for T2. Low and oscillatory shear (LOS) was positive correlation with LR2, and the elevated LOS occurred in the distal of LSA. CONCLUSION: Elongation of PDTA is associated with ATBAD, and the length ratio is a novel predictor. Elongated PDTA induced more aggressive hemodynamic forces, and high LOS regions may correspond to the entry tear location. The synergy of the morphological variation and aggressive hemodynamics creates contributory conditions for ATBAD.

  9. Computational Fluid Dynamics Simulation to Investigate Diffuser Outlet Factors in Anaerobic Membrane Bioreactors Treating Wastewater

    Haoran Wang, Makoto Ohta, Hitomi Anzai, Jiayuan Ji

    SUSTAINABILITY　15　(15)　2023/08

    DOI： 10.3390/su151511959 　

    eISSN： 2071-1050

  10. Effects of helical centerline stent vs. straight stent placement on blood flow velocity. International-journal

    Yutaro Kohata, Makoto Ohta, Kazuyoshi Jin, Hitomi Anzai

    Frontiers in medical technology　5　1196125-1196125　2023

    DOI： 10.3389/fmedt.2023.1196125 　

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    As an approach to maintain patency in femoropopliteal stenting, a helical stent configuration was proposed, which showed improved patency in clinical trials. However, the effects of helical stent placement on the flow have not been quantitatively analyzed. The purpose of this study was to estimate flow velocities to quantify the influence of helical stent placement. Helical and straight stents were implanted in three healthy pigs, and the flow velocities were estimated using the time-intensity curve (TIC) in the angiography images. The angiographic images indicated thinning of the leading edge of the contrast medium through the helically deformed artery, which was not observed in the straight stent. The slower rise of the TIC peak in the helical stent indicated faster travel of this thinner edge. Arterial expansion due to stenting was observed in all cases, and the expansion rate varied according to location. All cases of helical stent implantation showed that velocity was maintained (55.0%-71.3% velocity retention), unlike for straight stent implantation (43.0%-68.0% velocity retention); however, no significant difference was observed.

  11. A Review of Functional Analysis of Endothelial Cells in Flow Chambers

    Makoto Ohta, Naoya Sakamoto, Kenichi Funamoto, Zi Wang, Yukiko Kojima, Hitomi Anzai

    JOURNAL OF FUNCTIONAL BIOMATERIALS　13　(3)　2022/09

    DOI： 10.3390/jfb13030092 　

    eISSN： 2079-4983

  12. Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing Peer-reviewed

    Hitomi Anzai, Yugo Shindo, Yutaro Kohata, Masahiro Hasegawa, Hidemasa Takana, Tetsuro Matsunaga, Takaaki Akaike, Makoto Ohta

    Scientific reports　12　(1)　14849　2022/09/01

    DOI： 10.1038/s41598-022-18788-3 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  13. A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility

    Kohei Mitsuzuka, Yujie Li, Toshio Nakayama, Hitomi Anzai, Daisuke Goanno, Simon Tupin, Mingzi Zhang, Haoran Wang, Kazunori Horie, Makoto Ohta

    JOURNAL OF FUNCTIONAL BIOMATERIALS　13　(2)　2022/06

    DOI： 10.3390/jfb13020069 　

    eISSN： 2079-4983

  14. Comparing the Effect of Helical-centerline Stent Placement on Blood Flow Velocity with a Straight Stent

    Yutaro Kohata, Hitomi Anzai, Makoto Ohta

    2022/05/24

    DOI： 10.1101/2022.05.22.492620 　

  15. A machine learning strategy for fast prediction of cardiac function based on peripheral pulse wave. International-journal Peer-reviewed

    Sirui Wang, Dandan Wu, Gaoyang Li, Xiaorui Song, Aike Qiao, Ruichen Li, Youjun Liu, Hitomi Anzai, Hao Liu

    Computer methods and programs in biomedicine　216　106664-106664　2022/04

    DOI： 10.1016/j.cmpb.2022.106664 　

    ISSN： 0169-2607

    eISSN： 1872-7565

  16. Estimation of Blood Flow in a Stent using Time Intensity Curve Analysis

    Yutaro Kohata, Hitomi Anzai, Makoto Ohta

    UTM-IFS 3rd International Biofluid Symposium 2021　2021/11

  17. Influences brought by different wall shear stress analysis on curved vessels

    Fangjia Pan, Naoko Mori, Shunji Mugikura, Hitomi Anzai, Makoto Ohta

    UTM-IFS 3rd International Biofluid Symposium 2021　2021/11

  18. Endothelial Cell Distribution within Gap between Two Stent Struts after Flow Exposure

    Zi Wang, Narendra Kurnia Putra, Hitomi Anzai, Naofumi Ohtsu, Yukiko Kojima, Hanif Saifurrahman, Makoto Ohta

    UTM-IFS 3rd International Biofluid Symposium 2021　2021/11

  19. 広めたい! 血流 CFD の環 Invited

    安西眸, 太田 信, 庄島 正明, 藤村 宗一郎, 八木 高伸

    第 37 回 NPO 法人日本脳神経血管内治療学会学術集会　2021/11

  20. Evaluation of Normalization Methods in a Cerebral Artery Atlas for Automatic Labeling Peer-reviewed

    Kazuyoshi Jin, Ko Kitamura, Shunji Mugikura, Naoko Mori, Makoto Ohta, Hitomi Anzai

    Volume 5: Biomedical and Biotechnology　2021/11/01

    DOI： 10.1115/imece2021-71097 　

  21. Numerical Simulation in Lower Airway Using Eulerian Wall Film Model: Influence of Mucus Viscosity on Droplet Generation

    Yugo Shindo, Shunji Mugikura, Naoko Mori, Takaaki Akaike, Tetsuro Matsunaga, Makoto Ohta, Hitomi Anzai

    Eighteenth International Conference on Flow Dynamics - ICFD 2021　2021/10

  22. Assessing of the Relationship between WSS and TAV for Disturbed Flow on the Geometry of AVF for Hemodialysis

    Kazuki Takeda, Hitomi Anzai, Mingzi Zhang, Wang Haoran, Ai Kajiyama, Makoto Ohta

    Eighteenth International Conference on Flow Dynamics - ICFD 2021　2021/10

  23. Assessment of the thermal outcome during steam-pulse ablation for sheep tissue Peer-reviewed

    Hitomi Anzai, Rolf Stämpfli, Adriano Wang-Leandro, Luciano F. Boesel, Shelley Kemp, Rene M. Rossi, Agnieszka A. Karol, Makoto Ohta, Henning Richter

    Thermal Science and Engineering Progress　25　100966-100966　2021/10

    DOI： 10.1016/j.tsep.2021.100966 　

    ISSN： 2451-9049

  24. Finite element analysis of the mechanical performance of a zinc alloy stent with the tenon-and-mortise structure. International-journal Peer-reviewed

    Sirui Wang, Dandan Wu, Gaoyang Li, Kun Peng, Yongliang Mu, Makoto Ohta, Hitomi Anzai, Aike Qiao

    Technology and health care : official journal of the European Society for Engineering and Medicine　30　(2)　351-359　2021/07/23

    DOI： 10.3233/THC-212905 　

    ISSN： 0928-7329

    eISSN： 1878-7401

  25. Incomplete stent expansion in flow-diversion treatment affects aneurysmal haemodynamics: a quantitative comparison of treatments affected by different severities of malapposition occurring in different segments of the parent artery. International-journal Peer-reviewed

    Mingzi Zhang, Yujie Li, Shin-Ichiro Sugiyama, David I Verrelli, Yasushi Matsumoto, Teiji Tominaga, Yi Qian, Simon Tupin, Hitomi Anzai, Makoto Ohta

    International journal for numerical methods in biomedical engineering　37　(7)　e3465　2021/07

    DOI： 10.1002/cnm.3465 　

    ISSN： 2040-7939

    eISSN： 2040-7947

  26. Deep leaning network for predicting cardiovascular hemodynamics Invited

    Hitomi Anzai, Gaoyang Li, Keiichiro Shiraishi, Makoto Ohta

    Biofluids 2021 "Biofluid Symposium"　2021/06

  27. Endothelial cells distribution after the flow exposure experiment

    Z. Wang, H. Anzai, Y. Kojima, N. K. Putra, J.-P. Rieu, N. Ohtsu, H. Taniho, M. Ohta

    Lyon Saint Etienne & Nippon Scientific Network Engineering sciences Lyon Tohoku LyonSE&N – ELyT Workshop 2021　2021/06

  28. Virtual Angiography System as a Platform for Blood Flow estimation

    Y. Kohata, H. Anzai, M. Decroocq, S. Rit, C. Frindel, M. Ohta

    Lyon Saint Etienne & Nippon Scientific Network Engineering sciences Lyon Tohoku LyonSE&N – ELyT Workshop 2021　2021/06

  29. Implementation of computer simulation to assess flow diversion treatment outcomes: systematic review and meta-analysis International-journal Peer-reviewed

    Mingzi Zhang, Simon Tupin, Hitomi Anzai, Yutaro Kohata, Masaaki Shojima, Kosuke Suzuki, Yoshihiro Okamoto, Katsuhiro Tanaka, Takanobu Yagi, Soichiro Fujimura, Makoto Ohta

    JOURNAL OF NEUROINTERVENTIONAL SURGERY　13　(2)　164-170　2021/02

    DOI： 10.1136/neurintsurg-2020-016724 　

    ISSN： 1759-8478

    eISSN： 1759-8486

  30. ステント表面内皮化に対する流れ負荷実験の有用性

    小島有紀子, 王子, Narendra Kurnia Putra, 大津直史, 安西眸, 太田信

    2021年度 東北大学金属材料研究所共同研究ワークショップ・日本バイオマテリアル学会東北ブロック講演会　2021

  31. Effect of positioning of blood vessel on the hemodynamics prediction accuracy by deep learning

    Shiraishi Keiichiro, Ohta Makoto, Anzai Hitomi, Li Gaoyang

    Transactions of Japanese Society for Medical and Biological Engineering　Annual59　(Abstract)　510-510　2021

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.annual59.510 　

    ISSN： 1347-443X

    eISSN： 1881-4379

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    We have developed a novel deep learning network model to predict the hemodynamics in a short time from the aorta shape. However this network model needs a location registration in advance. The aim of this study is to find out relations between the location gap of the input data and prediction accuracy.Prediction accuracy was evaluated by the mean square error(MSE) of the velocity. The area where the training data exists was called the training range. One test data was located inside and outside of this range. Within the training range, there is the position where the prediction accuracy becomes higher than the original position. Outside of the range, there is non-linear tendency of sudden drop in accuracy. The errors become particularly large in the part where the patient-specific flow is observed.This study showed the importance of the location registration for the prediction accuracy on our network model.

  32. Numerical Simulation of Flow Behavior in Basilar Bifurcation Aneurysms Based on 4-Dimensional Computed Tomography Angiography Peer-reviewed

    Tomoaki Yamazaki, Gaku Tanaka, Ryuhei Yamaguchi, Yodai Okazaki, Hitomi Anzai, Fujimaro Ishida, Makoto Ohta

    World Journal of Mechanics　11　(04)　71-82　2021

    Publisher: Scientific Research Publishing, Inc.

    DOI： 10.4236/wjm.2021.114006 　

    ISSN： 2160-049X

    eISSN： 2160-0503

  33. Flush Flow Behaviour Affected by the Morphology of Intravascular Endoscope: A Numerical Simulation and Experimental Study. International-journal Peer-reviewed

    Yujie Li, Mingzi Zhang, Simon Tupin, Kohei Mitsuzuka, Toshio Nakayama, Hitomi Anzai, Makoto Ohta

    Frontiers in physiology　12　733767-733767　2021

    DOI： 10.3389/fphys.2021.733767 　

    ISSN： 1664-042X

  34. Endothelial Cell Distribution After Flow Exposure With Two Stent Struts Placed in Different Angles. International-journal Peer-reviewed

    Zi Wang, Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta

    Frontiers in physiology　12　733547-733547　2021

    DOI： 10.3389/fphys.2021.733547 　

    eISSN： 1664-042X

  35. Preface

    Takashi Tokumasu, Hitomi Anzai, Koji Fujita, Kenichi Funamoto, Makoto Hirota, Hisashi Nakamura, Koji Shimoyama, Hidemasa Takana

    JOURNAL OF FLUID SCIENCE AND TECHNOLOGY　16　(1)　2021

    DOI： 10.1299/jfst.2021jfst0001 　

    ISSN： 1880-5558

  36. Prediction of 3D Cardiovascular hemodynamics before and after coronary artery bypass surgery via deep learning International-journal Peer-reviewed

    Gaoyang Li, Haoran Wang, Mingzi Zhang, Simon Tupin, Aike Qiao, Youjun Liu, Makoto Ohta, Hitomi Anzai

    COMMUNICATIONS BIOLOGY　4　(1)　99-99　2021/01

    DOI： 10.1038/s42003-020-01638-1 　

    eISSN： 2399-3642

  37. Hemodynamic-Based Evaluation on Thrombosis Risk of Fusiform Coronary Artery Aneurysms Using Computational Fluid Dynamic Simulation Method Peer-reviewed

    Haoran Wang, Hitomi Anzai, Youjun Liu, Aike Qiao, Jinsheng Xie, Makoto Ohta

    COMPLEXITY　2020　2020/10

    DOI： 10.1155/2020/8507273 　

    ISSN： 1076-2787

    eISSN： 1099-0526

  38. A Hemodynamic-Based Evaluation of Applying Different Types of Coronary Artery Bypass Grafts to Coronary Artery Aneurysms Peer-reviewed

    Haoran Wang, Hitomi Anzai, Youjun Liu, Aike Qiao, Jinsheng Xie, Makoto Ohta

    COMPLEXITY　2020　2020/06

    DOI： 10.1155/2020/9359340 　

    ISSN： 1076-2787

    eISSN： 1099-0526

  39. The Relationship Between the Arterial Geometry and Wall Shear Stress in the Vertebrobasilar System Peer-reviewed

    Pan, Fangjia, Anzai, Hitomi, Mugikura, Shunji, Kitamura, Ko, and Ohta, Makoto

    Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition　Volume 3: Biomedical and Biotechnology Engineering　V003T04A038　2020/01

  40. INFLUENCE OF INPUT IMAGE CONFIGURATIONS ON OUTPUT OF A CONVLUTIONAL NEURAL NETWORK TO DETECT CEREBRAL ANEURYSMS Peer-reviewed

    Kazuhiro Watanabe, Hitomi Anzai, Norman Juchler, Sven Hirsch, Philippe Bijlenga, Makoto Ohta

    Proceedings of the ASME 2019 International Mechanical Engineering Congress and Exposition　Volume 3: Biomedical and Biotechnology Engineering　V003T04A021　2020/01

  41. Endothelial cell distributions and migration under conditions of flow shear stress around a stent wire International-journal Peer-reviewed

    Hitomi Anzai, Tomohito Watanabe, Xiaobo Han, Narendra Kurnia Putra, Zi Wang, Hisatoshi Kobayashi, Makoto Ohta

    TECHNOLOGY AND HEALTH CARE　28　(4)　345-354　2020

    DOI： 10.3233/THC-191911 　

    ISSN： 0928-7329

    eISSN： 1878-7401

  42. Pulse-Wave-Pattern Classification with a Convolutional Neural Network International-journal Peer-reviewed

    Gaoyang Li, Kazuhiro Watanabe, Hitomi Anzai, Xiaorui Song, Aike Qiao, Makoto Ohta

    SCIENTIFIC REPORTS　9　(1)　14930-14930　2019/10

    DOI： 10.1038/s41598-019-51334-2 　

    ISSN： 2045-2322

  43. Effects of Elasticity on Wall Shear Stress in Patient-Specific Aneurysm of Cerebral Artery Peer-reviewed

    Ryuhei Yamaguchi, Taihei Kotani, Gaku Tanaka, Simon Tupin, Kahar Osman, Nadia Shaira Shafii, Ahmad Zahran, Md Khudzari, Kazuhiro Watanabe, Hitomi Anzai, Atsushi Saito, Makoto Ohta

    Journal of Flow Control, Measurement & Visualization　7　(2)　73-86　2019/02

  44. Influence of input image configurations on output of a convolutional neural network to detect cerebral aneurysms

    Kazuhiro Watanabe, Hitomi Anzai, Norman Juchler, Sven Hirsch, Philippe Bijlenga, Makoto Ohta

    ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)　3　2019

    Publisher: American Society of Mechanical Engineers (ASME)

    DOI： 10.1115/IMECE2019-11125 　

  45. Preface

    Takashi Tokumasu, Hitomi Anzai, Koji Fujita, Makoto Hirota, Hisashi Nakamura, Koji Shimoyama, Hidemasa Takana

    JOURNAL OF FLUID SCIENCE AND TECHNOLOGY　14　(3)　2019

    DOI： 10.1299/jfst.2019jfst0014 　

    ISSN： 1880-5558

  46. Multiobjective design optimization of stent geometry with wall deformation for triangular and rectangular struts International-journal Peer-reviewed

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING　57　(1)　15-26　2019/01

    DOI： 10.1007/s11517-018-1864-6 　

    ISSN： 0140-0118

    eISSN： 1741-0444

  47. Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent

    Kun Peng, Aike Qiao, Makoto Ohta, Narendra Kurnia Putra, Xinyang Cui, Yongliang Mu, Hitomi Anzai

    CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES　117　(1)　17-28　2018/10

    DOI： 10.31614/cmes.2018.04113 　

    ISSN： 1526-1492

    eISSN： 1526-1506

  48. Computational Fluid Dynamics Analysis to Predict Endothelial Cells Migration During Flow Exposure Experiment With Placement of Two Stent Wires. International-journal Peer-reviewed

    Narendra Kurnia Putra, Zi Wang, Hitomi Anzai, Makoto Ohta

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2018　5454-5457　2018/07

    DOI： 10.1109/EMBC.2018.8513517 　

    ISSN： 1557-170X

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    Stent deployment is currently used for many cardiovascular treatments. During its application, the presence of the stent inside the blood vessel will indeed cause some change in both flow environment and also vessel wall's cellular conditions. This research intends to learn about the flow phenomenon of how vessel wall endothelial cells (ECs) react to the presence of stent wires within a microfluidic flow chamber environment. Computational fluid dynamics (CFD) simulation analysis of the microfluidic flow chamber system has been performed for observing the hemodynamics phenomena in the chamber. Moreover, CFD method also can be beneficial as a planning step for a successful experimental study. We found that under the two wires configurations, high wall shear stress (WSS) area is developed on the downstream side of the wires. Based on the analysis of WSS and WSS gradients (WSSG) conditions, ECs morphological change and migration are likely to occur some specific area.

  49. EXPERIMENTAL ANALYSIS FOR THE ANISOTROPIC FLOWS IN CANCELLOUS BONE Peer-reviewed

    Makoto Ito, Simon Tupin, Hitomi Anzai, Anna Suzuki, Makoto Ohta

    PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2017, VOL 3　3　2018

    DOI： 10.1115/IMECE2017-71346 　

  50. In search for a better stent: Surrogate based multi-objective optimization of stent design under influence of vessel wall deformation. International-journal Peer-reviewed

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2017　1344-1347　2017/07

    DOI： 10.1109/EMBC.2017.8037081 　

    ISSN： 1557-170X

    eISSN： 1558-4615

  51. Comparative Study between Different Strut’s Cross Section Shape on Minimizing Low Wall Shear Stress along Stent Vicinity via Surrogate-based Optimization Peer-reviewed

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    12th World Congress of Structural and Multidisciplinary Optimisation　2017/06/09

  52. Response Surface based Analysis to Improve the Intravascular Stent Design Performance on Optimizing Wall Shear Stress Conditions

    Putra Narendra Kurnia, Palar Pramudita Satria, Anzai Hitomi, Shimoyama Koji, Ohta Makoto

    Transactions of Japanese Society for Medical and Biological Engineering　55　(5)　415-415　2017

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.55Annual.415 　

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    <p>Restenosis is known as common problem during stent treatment. Stent optimization has been introduced to find the best design criteria in order to improve the endovascular treatment efficacy. Surrogate method is known as efficient method of optimization that has been built up from finite element method (FEM) simulation. Besides obtaining the optimized criteria, response surface plot which constructed by Kriging surrogate estimation process is also beneficial to study the behavior of design variables towards objective functions. In this study, we constructed the response surface map from stent design parameter configuration of strut size and inter-strut gap towards objective function. Our objective function is to minimizing the percentage of low wall shear stress area along deployment region. With this response surface, broad analysis on the stent performance can be clearly observed. More recommendations on how combinations between stent strut's size and gap should be designed are successfully obtained by this study.</p>

  53. Development of in-vitro experimental devices for in-situ evaluation of hemodynamic effects induced by endovascular devices and their deployment

    Tupin Simon, Anzai Hitomi, Ohta Makoto

    Transactions of Japanese Society for Medical and Biological Engineering　55　(5)　416-416　2017

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.55Annual.416 　

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    <p>Endovascular devices are medical devices inserted into the arteries in case of aneurysm. This minimally invasive treatment is preferred in case of aged patient. The number of commercially available device designs increased on the market but no data exist regarding direct comparisons of their performance, difficult to perform in vivo. The purpose of this research is to create in vitro experimental platforms allowing the study of the influence of those medical devices by monitoring the hemodynamic changes occurred during their deployments. Precise multi-scale evaluation of pressure and flow rate into the arteries surrounding the aneurysm are performed and synchronized to each step of the medical procedure. Further analysis are also conducted on the geometry of the deployed devices and flow pattern changes after deployment. As a proof of concept, studies of the treatment of an abdominal aortic aneurysm and an intracranial aneurysm are presented.</p>

  54. In Search for a Better Stent: Surrogate based Multi-Objective Optimization of Stent Design under Influence of Vessel Wall Deformation

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　1344-1347　2017

    ISSN： 1094-687X

    eISSN： 1558-4615

  55. Stent Design Optimization based on Kriging Surrogate Model under Deformed Vessel Wall: Pulsatile Inlet Flow Peer-reviewed

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    2017 5TH INTERNATIONAL CONFERENCE ON INSTRUMENTATION, CONTROL, AND AUTOMATION (ICA)　172-176　2017

    DOI： 10.1109/ICA.2017.8068435 　

    ISSN： 2379-755X

  56. COMPUTATIONAL FLUID DYNAMICS ANALYSIS OF THE BONE MARROW IN CANCELLOUS BONE AS A NON-NEWTONIAN FLUID Peer-reviewed

    Makoto Ohta, Wataru Sakuma, Toshio Nakayama, Hitomi Anzai, Makoto Ito, Katsuyuki Sado, Shuji Nakamura

    PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2016, VOL. 3　2017

  57. FLOW SIMULATIONS TO ESTABLISH THE RELATIONSHIP BETWEEN THE INFLOW ZONE IN THE NECK OF A CEREBRAL ANEURYSM AND THE POSITIONS OF STRUTS Peer-reviewed

    Kazuhiro Watanabe, Hitomi Anzai, Makoto Ohta

    PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2016, VOL. 3　2017

  58. Effects of Pulsatile Inlet Conditions on the Hemodynamic Conditions of Stent with Deformed Wall Simulations Peer-reviewed

    Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta

    PROCEEDINGS OF 2017 5TH INTERNATIONAL CONFERENCE ON INSTRUMENTATION, COMMUNICATIONS, INFORMATION TECHNOLOGY, AND BIOMEDICAL ENGINEERING (ICICI-BME)　57-61　2017

    ISSN： 2158-0456

  59. Towards the patient-specific design of flow diverters made from helix-like wires: an optimization study International-journal Peer-reviewed

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    BIOMEDICAL ENGINEERING ONLINE　15　(Suppl 2)　159-159　2016/12

    DOI： 10.1186/s12938-016-0257-z 　

    ISSN： 1475-925X

  60. Suppression of wall shear stress inside intracranial aneurysms by simple stents Invited Peer-reviewed

    Ryuhei Yamaguchi, Hitomi Anzai, Gaku Tanaka, Hao Liu, Makoto Ohta

    Neuroscience Communications　2　2016/09/05

    DOI： 10.14800/nc.1396 　

  61. 医工学分野におけるCAVE活用 Invited

    安西眸, 渡邉和浩, 張明子, Narendra Kurnia Putra, 竹島由里子, 太田信

    可視化情報　36　(143)　20-24　2016

    ISSN： 0916-4731

  62. Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing International-coauthorship Peer-reviewed

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11)　1　310-315　2015/06

  63. Parametric study of porous media as substitutes for flow-diverter stent Peer-reviewed

    Makoto Ohta, Hitomi Anzai, Yukihisa Miura, Toshio Nakayama

    BIOMATERIALS AND BIOMECHANICS IN BIOENGINEERING　2　(2)　111-125　2015/06

    DOI： 10.12989/bme.2015.2.2.111 　

    ISSN： 2465-9835

    eISSN： 2465-9959

  64. Flow in cancellous bone

    Wataru Sakuma, Hitomi Anzai, Toshio Nakayama, Makoto Ohta

    2015 ELyT lab Workshop　2015/02/20

  65. Optimization of endovascular prosthesis for the treatment ofcerebral aneurysms

    Hitomi Anzai, Makoto Ohta, Guy courbebaisse, Mingzi Zhang, Bastien Chopard, Yue zhang

    2015 ELyT lab Workshop　2015/02/20

  66. Introduction of Three Strut Optimization Strategies towards the Design of Efficient Flow-Diverter Stents

    Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    2015 ELyT lab Workshop　2015/02

  67. Porosity dependency of an optimized stent design for an intracranial aneurysm Peer-reviewed

    H. Anzai, Y. Yoshida, S. Sugiyama, H. Endo, Y. Matsumoto, M. Ohta

    TECHNOLOGY AND HEALTH CARE　23　(5)　547-556　2015

    DOI： 10.3233/THC-151007 　

    ISSN： 0928-7329

    eISSN： 1878-7401

  68. Automation of design optimization for intracranial stent

    Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta

    1st International symposium for collaborative research between Tohoku University and Technische Universität Braunschweig　2014/11/11

  69. An Optimization Method of FD Stent for Cerebral Aneurysm facing tne Stent Design and Manufacturing Needs

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　14　(204)　64　2014/09/03

  70. Development of Image Guided Minimal Invasive Treatments

    Makoto Ohta, Sho Matsumoto, Xiaobo Han, Mingzi Zhang, Yujie Li, Kaihong Yu, Hitomi Anzai

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　14　(204)　100-100　2014/09/03

  71. Optimization of stent design for intracranial aneurysm

    Hitomi Anzai, Yuuki Yoshida, Makoto Ohta

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　14　(204)　62-62　2014/09/03

  72. Manufacture-oriented Struts Structure Optimization of Flow Diverter for Intracranial Aneurysm Peer-reviewed

    Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    7th World Congress of Biomechanics (WCB2014)　2014/07/10

  73. The concept of Bundle of Inflow (BOI) for reducing flow in aneurysm

    Makoto Ohta, Hitomi Anzai, Mingzi Zhang, Yujie Li, Xiaobo Han, Kaihong Yu, Toshio Nakayama

    7th World Congress of Biomechanics (WCB2014)　2014/07/10

  74. Analysys of optimized design of stent

    H. Anzai

    Interdisciplinary Cerebrovascular Symposium　2014/06/03

  75. Optimization of Strut Placement in Flow Diverter Stents for Four Different Aneurysm Configurations International-journal Peer-reviewed

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Toshiyuki Hayase, Makoto Ohta

    JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME　136　(6)　061006-061006　2014/06

    DOI： 10.1115/1.4027411 　

    ISSN： 0148-0731

    eISSN： 1528-8951

  76. Combinational Optimization of Strut Placement for Intracranial Stent Using a Realistic Aneurysm Peer-reviewed

    Hitomi Anzai, Bastien Chopard, Makoto Ohta

    Journal of Flow Control, Measurement & Visualization　2　(2)　67-77　2014/04

    DOI： 10.4236/jfcmv.2014.22009 　

  77. Discussions of pressure distribution in artery with stenosis and aneurysm

    Yujie Li, Hitomi Anzai, Toshio Nakayama, Makoto Ohta

    Abstract　2014/02

  78. Model Study of Single Ventricular Heart Syndrome and its Treatment

    Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    Abstract　2014/02

  79. Study of blood flow in cerebral aneurysm with coil

    Makoto Ohta, Toshio Nakayama, Guy Courbebaisse, Hitomi Anzai, Han Xiaobo, Mingzi Zhang, Yujie Li, Kaihong Yu, Carolina Vallecilla, Ricardo A. Corredor

    Abstract　2014/02

  80. Simulation of hemodynamics in artery with aneurysm and stenosis with different geometric configuration Peer-reviewed

    Yujie Li, Hitomi Anzai, Toshio Nakayama, Yasumoto Shimizu, Yukihisa Miura, Aike Qiao, Makoto Ohta

    Journal of Biomechanical Science and Engineering　9　(1)　JSBE0003-JSBE0003　2014

    Publisher: Japan Society of Mechanical Engineers

    DOI： 10.1299/jbse.2014jbse0003 　

    ISSN： 1880-9863

  81. A Study on Multiscale Model in the presence of Systemic-to-Pulmonary Shunt utilizing Open-source CFD software Palabos

    M.Z. Zhang, H. Anzai, Y.J. Liu, M. Ohta

    APCOM & ISCM　2013/12

  82. Hemodynamic Numerical Simulation in Artery Complicated with both Stenosis and Aneurysm in Different Shape and Position

    Y.J. Li, H. Anzai, T. Nakayama, Y. Shimizu, Y. Miura, A.K. Qiao, M. Ohta

    APCOM & ISCM　2013/12

  83. Optimized Stent Invited

    Makoto Ohta, Hitomi Anzai, Toshio Nakayama, Xiaobo Han, Noriko Tomita

    The 10th ICFD, Sendai　580-581　2013/11/27

  84. Development of a Program for Blood flow and Cell Behaviors Based on LBM Method

    Makoto Ohta, Bastien Chopard, Hitomi Anzai

    AFI/TFI　2013/11

  85. Optimization of stent design to increase the porosity

    Yuuki Yoshida, Hitomi Anzai, Makoto Ohta

    Optimization of stent design to increase the porosity　2013/11

  86. Optimization of blood flow for intracranial stent

    Makoto Ohta, Hitomi Anzai, Han Xiaobo

    Workshop on Flow Dynamics related to Energy, Aerospace and Material Processing　2013/09/10

  87. In vitro strain measurements in cerebral aneurysm models for cyber-physical diagnosis International-journal Peer-reviewed

    Chaoyang Shi, Masahiro Kojima, Hitomi Anzai, Carlos Tercero, Seiichi Ikeda, Makoto Ohta, Toshio Fukuda, Fumihito Arai, Zoran Najdovski, Makoto Negoro, Keiko Irie

    INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY　9　(2)　213-222　2013/06

    DOI： 10.1002/rcs.1487 　

    ISSN： 1478-5951

    eISSN： 1478-596X

  88. Application of optimization for design of intracranial stent with blood flow reduction as objective function

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    WCSMO-10 10th World Congress and Structual and Multidisciplinary Optimization Program Book　2013/05

  89. Modeling Flow Diverter Stent using Porous Media

    Makoto Ohta, Yukihisa Miura, Hitomi Anzai, Toshio Nakayama

    Abstract　2012/10

  90. Stent designs for efficient reduction of intra-aneurismal flow with various aneurysms

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    Abstract　2012/10

  91. Optimum Design of Flow Diverter Stent Associated with Arterial Geometries

    Hitomi Anzai, Jean-Juc Falcone, Bastien Chopard, Makoto Ohta

    Proceedings Ninth International Conference on Flow Dynamics　2012/09

  92. Measurement of Pressure Drop for Modeling Intracranial Flow Diverter Stent Using Porous Medium

    Yukihisa Miura, Hitomi Anzai, Toshio Nakayama, Toshiyuki Hayase, Makoto Ohta

    Proceedings Ninth International Conference on Flow Dynamics　586-587　2012/09

  93. A Development of Lattice Boltzmann Model and Lumped Parameter Model Connection for Cardiovascular Multiscale Analysis

    Mingzi Zhang, Hitomi Anzai, Youjun Liu, Makoto Ohta

    不明　412-413　2012/09

  94. Characterization of Design of Stent Strut Positioning using LBM Method

    Makoto Ohta, Bastien Chopard, Hitomi Anzai

    不明　98-99　2012/09

  95. The Design Characteristics Extracted From an Optimal Flow Diverter in an Ideal Side-wall Aneurysm Using Lattice Boltzmann Method

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    不明　2012/07

  96. Computational fluid dynamic analysis following recurrence of cerebral aneurysm after coil embolization. International-journal Peer-reviewed

    Keiko Irie, Hitomi Anzai, Masahiko Kojima, Naomi Honjo, Makoto Ohta, Yuichi Hirose, Makoto Negoro

    Asian journal of neurosurgery　7　(3)　109-15　2012/07

    DOI： 10.4103/1793-5482.103706 　

    More details Close

    Hemodynamic factors are thought to play important role in the initiation, growth, and rupture of cerebral aneurysms. However, hemodynamic features in the residual neck of incompletely occluded aneurysms and their influences on recanalization are rarely reported. This study characterized the hemodynamics of incompletely occluded aneurysms that had been confirmed to undergo recanalization during long-term follow-up using computational fluid dynamic analysis. A ruptured left basilar-SCA aneurysm was incompletely occluded and showed recanalization during 11 years follow-up period. We retrospectively characterized on three-dimensional MR angiography. After subtotal occlusion, the flow pattern, wall shear stress (WSS), and velocity at the remnant neck changed during long-term follow-up period. Specifically, high WSS region and high blood flow velocity were found near the neck. Interestingly, these area of the remnant neck coincided with the location of aneurysm recanalization. High WSS and blood flow velocity were consistently observed near the remnant neck of incompletely occluded aneurysm, prone to future recanalization. It will suggest that hemodynamic factors may play important roles in aneurismal recurrence after endovascular treatment.

  97. Optimization of flow diverters for cerebral aneurysms Peer-reviewed

    Hitomi Anzai, Makoto Ohta, Jean-Luc Falcone, Bastien Chopard

    JOURNAL OF COMPUTATIONAL SCIENCE　3　(1-2)　1-7　2012/01

    DOI： 10.1016/j.jocs.2011.12.006 　

    ISSN： 1877-7503

  98. A Cyper-Physical System for Strain Measurements in the Cerebral Aneurysm Models Peer-reviewed

    Chaoyang Shi, Masahiro Kojima, Carlos Tercero, Hitomi Anzai, Makoto Ohta, Katsutoshi Ooe, Seiichi Ikeda, Toshio Fukuda, Fumihito Arai, Makoto Negoro, Keiko Irie, Guiryong Kwon

    2012 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS)　4137-4142　2012

    DOI： 10.1109/IROS.2012.6385754 　

    ISSN： 2153-0858

  99. Hemodynamic of an Unruptured Cerebral Aneurysm before Its Rupture-Predicting the Risk of a Cerebral Aneurysm Rupture Using Computational Fluid Dynamics- Peer-reviewed

    入江恵子, 太田信, 安西眸, 根來真, 廣瀬雄一

    CI研究　33　(2)　119-125　2011

    ISSN： 0918-7073

  100. THE EFFECT OF 3D VISUALIZATION ON OPTIMAL DESIGN FOR STRUT POSITION OF INTRACRANIAL STENT Peer-reviewed

    Hitomi Anzai, Toshio Nakayama, Yuriko Takeshima, Makoto Ohta

    PROCEEDINGS OF THE ASME FLUIDS ENGINEERING DIVISION SUMMER CONFERENCE - 2010 - VOL 1, PTS A-C　1859-1867　2010

  101. Analysis of Three-Dimensional Structure with Subunit Mismatch Arrangements of Staphylococcal γ-hemolysin Heteroheptameric Transmembrane Pore Peer-reviewed

    Noriko Tomita, Hitomi Anzai, Kazuyo Abe, Makoto Ohta

    Microscopy　45　(4)　223-228　2010

    Publisher: The Japanese Society of Microscopy

    DOI： 10.11410/kenbikyo.45.4_223 　

    ISSN： 1349-0958

    eISSN： 2434-2386

    More details Close

    Staphylococcal γ-hemolysin (Hlg) consists of two separate proteins, Hlg1 (34kDa) and Hlg2 (32kDa), which lyses cooperatively mammalian erythrocytes. We have been studied pore-forming nature and assembly of Hlg on the membrane and revealed that Hlg1 and Hlg2 assemble alternately to form heteroheptameric transmembrane pores with subunit stoichiometries of 3:4 and 4:3. However, the three-dimentional (3-D) structure of Hlg pore complex has not been clarified yet. In this study, our aim is reconstruction of 3-D structure of the pore having a characteristic molecular arrangement in asymmetrical heteroheptamer, based on high-resolution electron transmission miscroscopic (TEM) images. The shapes and sizes of subunit in the pore were measured on the basis of TEM image and the 3-D structure was constructed with computer-aided design software. As a result, it is estimated the pore forms a cylindrical structure in a superior region and funnel-shaped structure in an inferior region. That is, seven subunits bend to inside at the bottom of superior region and small cylindrical pore structure acting as functional transmembrane pore is attached. Additionally, it is revealed that several subunits are arranged out of order from vertexes of regular heptagon and largest mismatch subunit angle against the regular heptagon reachs approximately 15 degree.

  102. 3TA5-05 Three-dimentional structure analysis of staphylococcal γ-hemolysin heteroheptameric transmembrane pore complex(The 47th Annual Meeting of the Biophysical Society of Japan)

    Tomita Noriko, Anzai Hitomi, Kaneko Jun, Kamio Yoshiyuki, Ohta Makoto

    Seibutsu Butsuri　49　S58-S59　2009

    Publisher: The Biophysical Society of Japan General Incorporated Association

    DOI： 10.2142/biophys.49.S58_5 　

Show all ︎Show first 5

Misc. 45

  1. ステント表面およびステント形状が流れ存在下の内皮細胞挙動に与える影響 Invited

    王子, Hanif Saifurrahman, 小島有紀子, 安西眸, 大津真史, 太田信

    バイオマテリアル -生体材料-　41　(3)　196-201　2023/07

  2. ヘリカルステント留置による血流変化の観察 -コンピュータシミュレーションと動物実験- Invited

    安西眸, 木幡雄太郎, 武田和輝, 太田信

    Coronary Intervention　19　(4)　100-104　2023/07

  3. Normalization of Basilar Artery Structure with MRA Images

    北村洸, 麦倉俊司, 太田信, 安西眸

    日本機械学会バイオフロンティア講演会講演論文集(CD-ROM)　30th　1C15　2019

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebiofro.2019.30.1c15 　

    ISSN： 1348-2939

    eISSN： 2424-2810

  4. Systematic review of hemodynamic discriminators for ruptured intracranial aneurysms

    Yagi Takanobu, Okamoto Yoshihiro, Ohta Makoto, Nakamura Masanori, on behalf of the CFD-BIO study group, Ishida Fujimaro, Shojima Masaaki, Anzai Hitomi, Fujimura Souichiro, Sano Takanori, Shinozaki Shun, Yamanaka Yuuma, Yamamoto Yuuto

    Journal of Biorheology　33　(2)　53-64　2019

    Publisher: JAPANESE SOCIETY OF BIORHEOLOGY

    DOI： 10.17106/jbr.33.53 　

    ISSN： 1867-0466

    More details Close

    <p>Researchers have aimed to identify unruptured intracranial aneurysms at a higher risk of rupture during follow-up for a long time. Computational fluid dynamics has been used widely to identify a hemodynamic discriminator between ruptured and unruptured aneurysms. However, this method has yet to reach a consensus between groups, which may be due, in part, to the significant degrees of freedom in hemodynamic indexes and computational workflows. The present review aims to characterize the degree of association between ruptured aneurysms and hemodynamic indexes, as well as the degree of variability between groups. A PubMed search identified 588 relevant studies. Thirteen met our criteria, yielding a total of 3,692 aneurysms. The definition of hemodynamic indexes were first carefully assessed and then classified accordingly. The variability of hemodynamic indexes between groups displayed a significant index-dependent nature. Normalizing hemodynamic indexes was an effective measure of reducing variability. Hemodynamic indexes were evaluated for associability and quantifiability. Overall, in an attempt to advance the diagnostic performance of hemodynamic indexes, these results shed light on the poor ability to interpret hemodynamic states pathologically. Future studies should incorporate the pathological significance of hemodynamic states into the design of hemodynamic indexes.</p>

  5. Hemodynamic Study on Coronary Artery Aneurysms with Bypass Surgery

    Haoran Wang, Hitomi Anzai, Makoto Ohta, Youjun Liu

    15th ICFD (Internatinal Conference of Fluid Dynamics)　2018/11

  6. PIV MEASUREMENT IN AN IDEAL ANEURYSMAL MODEL USING A TRANSPARENT COIL MODEL Peer-reviewed

    Makoto OHTA, Masanori KUZE, Simon TUPIN, Kaihong YU, Yasutomo SHIMIZU, Hitomi ANZAI

    Conference on Modelling Fluid Flow (CMFF’18)　2018/07

  7. Dose hypertension history affect morphology or hemodynamic characteristics of Cerebrobasilar System? Retrospetive study of 249 patients diagnosed with hypertension. Peer-reviewed

    Yujie Li, Mingzi Zhang, Ko Kitamura, Hitomi anzai, Shuji Mugikura, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  8. Characteristics of Elasticity on Flow Behavior in Middle Cerebral Aneurysm Model Peer-reviewed

    Ryuhei Yamaguchi, Gaku Tanaka, Taihei Kotani, Kahar Osman, Nadia Shafii, Hitomi Anzai, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  9. Can morphology or haemodynamic characteristics of verteebrobasilar system be identifier of hypertension Peer-reviewed

    Ko Kitamura, Yujie Li, Mingzi Zhang, Hitomi Anzai, Shuji Mugikura, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  10. Multiobjective Optimization of Stent Design towards In-Stent Restenosis

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  11. Pulse pattern classification of atherosclerotic patients based on convolutional neural network

    Li Gaoyang, Anzai Hitomi, Watanabe Kazuhiro, Qiao Aike, Ohta Makoto

    The Proceedings of the JSME Conference on Frontiers in Bioengineering　2018.29　2C11　2018

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebiofro.2018.29.2c11 　 10.1038/s41598-019-51334-2_references_DOI_DGABgnXW2V9ZPOSKNTUf6jSoCY6 　

    eISSN： 2424-2810

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    Pulse wave contains a lot of cardiovascular diseases (CVD) information. It can be used as an early diagnostic method for CVD. Previous studies have shown that the pulse wave of atherosclerotic patients are significantly different from those of healthy subjects. In this study, we extracted 210 pulse wave cycles from atherosclerotic patients. At the same time, as a control group, we extracted the same number of pulse cycles from healthy subjects. An optimized convolution neural network (CNN) was proposed to classify these two pulse patterns. The proposed CNN had good performance with 95% accuracy on distinguishing arteriosclerosis vs non- arteriosclerosis. Our study showed that CNN could identify pulse waves in atherosclerosis patients with high accuracy. It could help to develop a non-invasive and efficient method for arteriosclerosis detection.

  12. Simulation research on hemodynamic of surgery of coronary artery aneurysm

    WANG Haoran, ANZAI Hitomi, LIU Youjun, OHTA Makoto

    The Proceedings of Mechanical Engineering Congress, Japan　2018　J0210303　2018

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecj.2018.j0210303 　

    eISSN： 2424-2667

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    Coronary artery aneurysm (CAA) is an unusual disease whose incidence was reported as 0.14-4.9%. Currently, CAA usually is treated with coronary artery bypass grafting (CABG) surgery. However, there is limited evidence to prove which operation procedure, including bypass by saphenous vein graft (SVG) or left internal mammary artery (LIMA) with or without ligation of CAA, is better to treat this disease. At present, studies have shown that hemodynamic parameters are an important basis which can supply evidence to make the evaluation for different surgery. Therefore, we study the feasibility of different operating procedures from a hemodynamic point of view. Here we present four 3D models with coronary arteries and aortic arch named Model 1-4 (SVG/LIMA with CAA, SVG/LIMA without CAA, respectively). In order to reduce the computational requirements and obtain good boundary conditions, lumped parameter model (LPM, 0D model) coupled with 3D models. The mass-flow of SVG and LIMA, wall shear stress (WSS) and oscillatory shear index (OSI) were evaluated. Normal WSS and low OSI in grafting region appeared in Model 1, 3, and 4. Inverse flow, normal WSS, and high OSI put in an appearance on the LIMA in Model 2. Based on previous work, inverse graft flow and high OSI can make bypass graft invalid. Therefore, from a hemodynamic point of view, SVG and LIMA both can be used as the bypass graft to treat the CAA. However, CAA should be ligated when LIMA is used.

  13. Effect of input image representation for results of neural network to detect cerebral aneurysms

    WATANABE Kazuhiro, ANZAI Hitomi, JUCHLER Norman, HIRSCH Sven, Bijlenga Philippe, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　31st　2D14　2018

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2019.31.2d14 　

    ISSN： 2424-2829

    eISSN： 2424-2829

  14. Analysis of relationship between aneurysmal flow and stent struts by using the lattice Boltzmann method

    渡邉和浩, 安西眸, 太田信

    計算工学講演会論文集(CD-ROM)　23　4p　2018

    Publisher: 日本計算工学会

    ISSN： 1342-145X

  15. Location related variability of permeability characteristics in cancellous bone

    Ito Makoto, Tupin Simon, Anzai Hitomi, Suzuki Anna, Ohta Makoto

    Proceedings of the 14th International Conference on Flow Dynamics　834-835　2017/11

  16. 海綿骨内における浸透率測定

    伊藤誠, TUPIN Simon, 安西眸, 鈴木杏奈, 太田信

    日本バイオレオロジー学会誌(Web)　31　(2)　2017

    ISSN： 2186-5663

  17. 血管モデルの開発と動物実験

    太田信, 大西泰平, TUPIN Simon, 清水康智, 于凱鴻, 安西眸

    日本実験動物学会総会講演要旨集　64th　2017

  18. 教育用,評価用,プレオペ用血管モデルの開発

    太田信, 清水康智, 于凱鴻, TUPIN Simon, 安西眸

    日本医学放射線学会秋季臨床大会抄録集　53rd　2017

    ISSN： 0048-0428

  19. Introduction of numerical simulation being applied to the study of aneurysm treatment with flow-diverting stent

    ZHANG Mingzi, LI Yujie, ANZAI Hitomi, SEN Itsu, OHTA Makoto

    The Proceedings of Mechanical Engineering Congress, Japan　2017　(0)　J0230204　2017

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecj.2017.J0230204 　

    eISSN： 2424-2667

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    <p>Intracranial aneurysms (IAs) account for a large portion of cerebrovascular disorders and can be treated with flow-diverting (FD) stents. To aid the treating clinicians with determination of a favourable treatment plan, we adopted numerical simulation methods to the optimisation of FD treatment, including the design optimisation of FD stent wire structure, as well as the optimisation of FD stent treatment procedure. Our simulation results suggest that both stent design and stent deployment may drastically affect the FD treatment outcomes; numerical simulation prior to the real treatment may therefore assist the treating clinicians in predicting the treatment outcomes.</p>

  20. MFM evaluation using a flow rate and pressure controlled in-vitro model

    TUPIN Simon, SHIMIZU Yasumoto, OHTA Makoto, ANZAI Hitomi

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2017　(0)　2B34　2017

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2017.29.2B34 　

    eISSN： 2424-2829

  21. 低レイノルズ数領域における血液環流フローチャンバーシステムの開発

    安西眸, 白石泰之, 山家智之, 太田信

    日本バイオレオロジー学会誌(Web)　30　(2)　2016

    ISSN： 2186-5663

  22. AVEC CFD2016

    安西眸, TUPIN Simon, 渡邉和浩, RASHAD Sherif, 太田信

    日本バイオレオロジー学会誌(Web)　30　(2)　2016

    ISSN： 2186-5663

  23. 脳血管内治療デバイスと治療の有効性を予測する血管モデルの開発

    太田信, TUPIN Simon, 清水康智, 于凱鴻, 安西眸

    脳血管内治療(Web)　1　(Supplement)　2016

    ISSN： 2424-1709

  24. Development of Artery Biomodel for Endovascular Treatment

    Ohta Makoto, Shimizu Yasutomo, Tupin Simon, Onishi Taihei, Muramoto Yuta, Seiller Joanna, Yu Kaihong, Anzai Hitomi

    The Proceedings of Mechanical Engineering Congress, Japan　2016　(0)　W021003　2016

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecj.2016.W021003 　

    ISSN： 2424-2667

    eISSN： 2424-2667

  25. 2F22 The effect of strut position relative to inflow zone of aneurysm neck on flow

    WATANABE Kazuhiro, ANZAI Hitomi, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　28th　(0)　_2F22-1_-_2F22-4_　2016

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2016.28._2F22-1_ 　

    ISSN： 2424-2829

    eISSN： 2424-2829

    More details Close

    For the treatment of cerebral aneurysms, flow diverter (FD) stent placement has been attracted. To evaluate a positioning error of stent on aneurysm flow, we analyze an influence of strut positions with relation to the inflow zone. Lattice Boltzmann flow simulation was applied to compute flow velocity in 3-D ideal aneurysm with a curved parent artery. Rectangular solid as a strut model was placed along to the neck plane. The results suggest that the flow velocity in the aneurysm is effectively reduced when the flow in the aneurysm and parent vessel flow are separated by a strut.

  26. 脳動脈瘤の生化学的イベントと数値流体解析の応用に関するCutting‐Edge

    安西眸, ZHANG Mingzi, PUTRA Narendra Kurnia, 渡邉和浩, 太田信

    脳血管内治療(Web)　1　(Supplement)　S47(J‐STAGE)　2016

    ISSN： 2424-1709

  27. CFDで何をみるのか,見えるのか AVEC CFD2015

    安西眸, 下權谷祐児, 太田信, 八木高伸, 高尾洋之, 河野健一, 庄島正明

    日本バイオレオロジー学会年会プログラム・抄録集　38th　2015

  28. S0220301 Design analysis of optimized stent for intracranial aneurysm using Self-organizing maps

    ANZAI Hitomi, YOSHIDA Yuuki, SHIMOYAMA Koji, OBAYASHI Shigeru, OHTA Makoto

    The Proceedings of Mechanical Engineering Congress, Japan　2015　(0)　_S0220301--_S0220301-　2015

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecj.2015._S0220301- 　

    ISSN： 2424-2667

    eISSN： 2424-2667

    More details Close

    As evaluation of hemodynamics in an aneurysm, a lot of parameters have been introduced. However, the relationship between stent geometry and each hemodynamic parameter is not clear enough. We applied Self-organizing Maps (SOM) to search the detailed relationship between stent strut and hemodynamic parameters. Two thousands of stent design candidates evaluated with five hemodynamic parameters and 25 stent geometry parameters were stored during the optimization process. By using SOM software, 2,000 design candidates were visualized into 30 2D-maps while preserving their own features in the original 30-dimensional design space. Each map was divided into 20 clusters to characterize stent design and flow reduction. By comparing each cluster, critical design for reduction effect of each hemodynamic parameter is suggested. Strut placement on the inflow area is important to reduce maximum shear rate. In addition to the inflow area, strut on the outflow area is required to reduce velocity, vorticity, and average shear rate.

  29. CFD analysis of flow in cancellous bone

    Sakuma Wataru, Nakayama Toshio, Anzai Hitomi, Nakamura Shuji, Sado Katsuyuki, Takagawa Hirokazu, Ohta Makoto

    The Computational Mechanics Conference　2014　(27)　366-367　2014/11/22

    Publisher: The Japan Society of Mechanical Engineers

    ISSN： 1348-026X

  30. 脳動脈瘤治療用ステントにおける数値解析を用いた最適設計—Optimization of stent design based on computational fluid dynamics study

    安西眸, Bastien Chopard, 太田信

    19　3p　2014/06

  31. CFD analysis of flow in cancellous bone

    Sakuma Wataru, Nakayama Toshio, Anzai Hitomi, Nakamura Shuji, Sado Katsuyuki, Takagawa Hirokazu, Ohta Makoto

    The Proceedings of The Computational Mechanics Conference　27th　(0)　366-367　2014

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmecmd.2014.27.366 　

    ISSN： 2424-2799

    eISSN： 2424-2799

  32. Design Optimization of intracranial stent to encourage blood coagulation in aneurysm

    吉田裕貴, 安西眸, 太田信

    日本機械学会最適化シンポジウム(CD-ROM)　11th (Web)　3p-_1204-3_　2014

    Publisher: 日本機械学会

    DOI： 10.1299/jsmeopt.2014.11.0__1204-1_ 　

    eISSN： 2433-1295

    More details Close

    Flow diverter stent (FD) is one of an efficient medical device or intracranial aneurysm. FD is a cylindrical device woven from metallic wires. It blocks the inflow entering an aneurysm to make blood coagulation in the aneurysm. But the device has a risk of blood coagulation as well in the parent artery attributable to chemical reactions between metal and blood. Therefore, we have developed the optimization program for mesh design of FD with simulated annealing and computational fluid dynamics to improve the treatment effect maintaining low wire density. In this report, we investigate the relationship between hemodynamic parameters and mesh design to determine the objective function for FD optimization.

  33. 脳動脈瘤治療用ステントにおける数値解析を用いた最適設計

    安西眸, CHOPARD Bastian, 中山敏男, ZHANG Mingzi, 吉田裕貴, 太田信

    計算工学講演会論文集(CD-ROM)　19　ROMBUNNO.D-3-2　2014

    ISSN： 1342-145X

  34. ステントの最適デザインを考える

    太田信, 安西眸, 吉田裕貴, Mingzi Zhang, Yujie Li, 中山敏男

    脳神経外科速報　24　(5)　532-357　2014

    ISSN： 0917-1495

  35. 3C08 Design optimization of flow diverter stent using realistic aneurysm

    ANZAI Hitomi, FALCONE Jean-Luc, CHOPARD Bastien, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　25th　(0)　535-536　2013

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2013.25.535 　

    ISSN： 1348-2920

    eISSN： 2424-2829

  36. Optimization of intracranial stent design for flow reduction

    Ohta Makoto, Anzai Hitomi, Nakayama Toshio

    NCTAM papers, National Congress of Theoretical and Applied Mechanics, Japan　62nd　(0)　200-200　2013

    Publisher: National Committee for IUTAM

    DOI： 10.11345/japannctam.62.0.200.0 　

    More details Close

    The design optimization of stents (or flow diverters) from the view point of fluid dynamics has attracted attentions in recent years. However, the conventional optimization requires huge time and efforts to generate geometries and meshes. Therefore we have introduced the possibility to use lattice Boltzmann (LB) flow simulations in combination with simulated annealing (SA) optimization that explore the design of stents for 2-D aneurysms, in a fully automated way.This report demonstrates the optimization for 3-D aneurysm with two different objectives. As the result, optimum stent varies with the objectives.

  37. 医療デバイス周りの血流流体力学的見地からの血栓形成

    太田信, WETZEL S., 安西眸, 中山敏男, HAN Xiaobo, 清水康智, 小澤桂, 冨田典子

    日本バイオマテリアル学会シンポジウム予稿集　2012　2012

  38. 7F24 Development of optimization program for flow diverters based on lattice Boltzmann method

    ANZAI Hitomi, FALCONE Jean-Luc, CHOPARD Bastien, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　24th (CD-ROM)　(0)　_7F24-1_-_7F24-2_　2012

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2012.24._7F24-1_ 　

    ISSN： 1348-2920

    eISSN： 2424-2829

  39. 107 Relationship between Pressure Gradient and Flow in Aneurysm for Modeling Flow Diverter Stent in Cerebrl Aneurysm

    MIURA Yukihisa, ANZAI Hitomi, NAKAYAMA Toshio, OHTA Makoto

    The Proceedings of Conference of Tohoku Branch　47th　(0)　20-21　2012

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmeth.2012.47.20 　

    eISSN： 2424-2713

  40. S021022 Automated Optimization of Strut Position for Intracranial Aneurysm

    ANZAI Hitomi, FALCONE Jean-Luc, CHOPARD Bastien, OHTA Makoto

    The Proceedings of Mechanical Engineering Congress, Japan　2012　(0)　_S021022-1-_S021022-3　2012

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecj.2012._S021022-1 　

    ISSN： 2424-2667

    eISSN： 2424-2667

    More details Close

    To produce an optimal design of stents for cerebral aneurysm is attracted for reducing the flow in the aneurysm efficiently. This report demonstrates the optimization for 3-D aneurysm with two different objectives. As the result, the optimum stent for the maximum velocity has denser struts on distal of the neck. On the other hand, the optimum stent for average velocity has denser struts on proximal of the neck.

  41. 8F-15 Prediction of effective position for intracranial stent using 3D visualization of numerical analysis of blood flow

    ANZAI Hitomi, NAKAYAMA Toshio, IRIE Keiko, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　23rd　(0)　253-254　2011

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmebio.2010.23.253 　

    ISSN： 1348-2920

    eISSN： 2424-2829

  42. 未破裂脳動脈瘤の破裂リスクに関する3次元可視化システムを用いたCFD解析の試み

    入江恵子, 太田信, 安西眸, 中山敏男, 根來真, 廣瀬雄一

    日本バイオレオロジー学会年会プログラム・抄録集　34th　53　2011

  43. ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロヘプタマー膜孔複合体の立体構築とサブユニット間配置の定量的解析

    冨田典子, 安西眸, 阿部和代, 金子淳, 神尾好是, 太田信

    日本農芸化学会大会講演要旨集　2010　2010

  44. ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロヘプタマー膜孔複合体の立体構造解析

    冨田典子, 安西眸, 金子淳, 神尾好是, 太田信

    日本ブドウ球菌研究会プログラム・講演要旨集　54th　2009

  45. 3D visualization of numerical simulation of blood flow on intracranial stent

    安西眸, 竹島由里子, 中山敏男, 太田信

    日本機械学会年次大会講演論文集　2009　(Vol.6)　177-178　2009

    Publisher: The Japan Society of Mechanical Engineers

    DOI： 10.1299/jsmemecjo.2009.6.0_177 　

    eISSN： 2433-1325

    More details Close

    The effect of stent on the flow reduction in cerebral aneurysm has been reported in CFD studies showing the stent position or the strut shape may affect the flow reduction. The 3D visualization may help easily to specify the inlet zone from parent artery to aneurysm and to find the relationship between the effective strut position and the flow pattern. Then we simulated adding a strut to a stent model on the inlet zone after specifying the zone using 3D visualization system. After moving the strut and repeating the visualization of results, we found a strut on the zone may reduce the flow into aneurysm effectively. The results may suggest the 3D visualization is useful for the assessment of strut position with effective reduction of flow into aneurysm.

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Books and Other Publications 1

  1. 基礎からよくわかる 実践的CFD(数値流体力学)入門 脳血管編

    山本 誠, 根本 繁, 髙尾 洋之

    メディカ出版　2017/03/24

    ISBN: 4840461473

Presentations 216

  1. The effect of asymmetricity in stenosis on blood flow

    Keito Yanagisawa, Carole Frindel, Damien Garcia, Makoto Ohta, Hitomi Anzai

    ELyT Workshop 2024

  2. フローチャンバーシステムを用いた血管内皮細胞の流れ負荷応答の解明 Invited

    安西眸, Zi Wang, Hanif Saifurrahman, 太田信

    2023年度東北大学金属材料研究所共同研究ワークショップ日本バイオマテリアル学会東北ブロック交流会

  3. 慢性関節炎治療のための血流−粒子連成シミュレーション解析：血流速度による塞栓位置の差異

    後庵野大輔, 内田達也, 小黒草太, 高瀬圭, 津田俊幸, 安西眸, 太田信

    第57回日本生体医工学会東北支部大会

  4. Hemodynamic Management of Patients with Coronary Artery Stenosis Before and After Stent Implantation

    X. Song, X. Wang, N. Li, S. Wang, C. Zhu, H. Anzai, M. Ohta

    Twentieth International Conference on Flow Dynamics, The 23rd International Symposium on Advanced Fluid Information (AFI-2023)

  5. Experiment on Mechanical Integrity Evaluation of Degradable Zinc Wire under Tensile Load in Flowing Medium

    S. Chen, B. Guo, T. Du, A. Qiao, H. Song, W. Fu, H. Anzai, M. Ohta

    wentieth International Conference on Flow Dynamics, The 23rd International Symposium on Advanced Fluid Information (AFI-2023)

  6. Development of a Flow Field Estimation Method based on Cerebrovascular Images: Stabilization and Speedup of CFD Data Acquisitiion for Training Datasets

    H. Anzai, K. Shibata, G. Li, H. Wang, K. Yanagisawa, S. Sugiyama

    Twentieth International Conference on Flow Dynamics, The 23rd International Symposium on Advanced Fluid Information (AFI-2023)

  7. Numerical Simulation of Droplet Generation on the SSub--MMicrofluidic Channel

    N. K. Putra, F. Z. Sarwono, I. Anshori, M. Ohta, H. Anzai

    Twentieth International Conference on Flow Dynamics, The 23rd International Symposium on Advanced Fluid Information (AFI-2023)

  8. The Effect of Oscillatory Shear Index (OSI) on Endothelial Cell Behavior Observed in a Flow Chamber

    H. Saifurrahman, Z. Wang, H. Anzai, M. Ohta

    Twentieth International Conference on Flow Dynamics

  9. 粒子を用いた微小血管塞栓術の定量化

    内田達也, 後庵野大輔, 小黒草太, 高瀬圭, 太田信, 安西眸

    ソフトバイオ研究会2023

  10. VALIDATION OF THE EFFECT OF OSI ON ENDOTHELIAL CELL’S BEHAVIOR IN A FLOW CHAMBER

    Hanif Saifurrahman, Zi Wang, Yukiko Kojima, Hitomi Anzai, Makoto Ohta

    6th Japan-Switzerland Workshop on Biomechanics

  11. Development of CFD with macroscopic particle model (MPM) for embolic particles selection

    Daisuke Goanno, Sota Oguro, Kei Takase, Toshiyuki Tsuda, Hitomi Anzai, Makoto Ohta

    19th Interdisciplinary Cerebrovasucular Symposium

  12. Synthetic Artery Cohort: A new method to reproduce the distribution of morphological parameters

    Kazuyoshi Jin, Ko Kitamura, Syunji Mugikura, Naoko Mori, Makoto Ohta, Hitomi Anzai

    19th Interdisciplinary Cerebrovasucular Symposium

  13. Synthetic database of arterial network and its variability Invited

    Hitomi Anzai

    19th Interdisciplinary Cerebrovasucular Symposium

  14. 3D blood flow field estimation network based on vascular morphology information Invited

    Hitomi Anzai

    NYCU-TU Joint Workshop

  15. 下気道における吸気時の吸入速度が飛沫沈着に及ぼす影響

    長谷川将大, 安西眸, 太田信

    日本機械学会 第35回バイオエンジニアリング講演会

  16. 微小血管塞栓術の定量評価に向けた粒子塞栓を伴うCFD解析の手法の提案

    後庵野大輔, 小黒草太, 高瀬圭, 津田俊幸, 安西眸, 太田信

    第62回日本生体医工学会大会2023

  17. 数値流体力学とディープラーニングの連成による血行動態解析の高速化手法の開発

    柴田和樹, 白石敬一郎, 太田信, 安西眸

    第62回日本生体医工学会大会2023

  18. 仮想脳血管形状群の生成：多変量正規性を用いたアプローチ

    神容慶, 北村洸, 麦倉俊司, 森奈緒子, 太田信, 安西眸

    第62回日本生体医工学会大会2023

  19. 安西眸, 神容慶, 白石敬一郎, 柴田和樹, 太田信

    次元血流場推定ネットワーク構築のためのバーチャルポピュレーション構築の試み

    東北大学・統計数理研究所合同ワークショッププログラム

  20. 血管角度と動脈瘤形成の相関性

    潘 方家, Bijlenga Philippe, 森 菜緒子, 麦倉 俊司, 太田 信, 安西 眸

    日本機械学会東北支部第59期総会・講演会

  21. ３次元気道モデルにおけるDPM-EWF飛沫生成シミュレーション

    小林 直輝, 長谷川 将大, 太田 信, 安西 眸

    日本機械学会東北支部第59期総会・講演会

  22. 粒子塞栓実験をふまえたMPMシミュレーション解析

    内田 達也, 後庵野 大輔, 小黒 草太, 高瀬 圭, 太田 信, 安西 眸

    日本機械学会東北支部第59期総会・講演会

  23. 数値流体力学と深層学習の連成による血行動態解析の高速化手法の開発（第三報）：頸動脈付き大動脈形状への適用

    柴田 和樹, 王 浩然, 李 高陽, 太田 信, 安西 眸

    日本機械学会東北支部第59期総会・講演会

  24. 静脈洞モデルのCFDシミュレーションにおける六面体、多面体、四面体メッシュの比較

    木幡 雄太郎, 安西 眸, 太田 信, Carole Frindel, François-Régis Hammer, Stéphanie Salmon, Damien Garcia

    日本機械学会東北支部第59期総会・講演会

  25. 相対ベクトルを用いた頸動脈と大動脈の統計形状モデルの作成手法の提案と評価

    白石敬一郎, Decroocq Meghane, 太田信, Li Gaoyang, Wang Haoran, Frindel Carole, 安西眸

    日本機械学会 第33 回バイオフロンティア講演会

  26. Observation of Endothelial Cell Migration and Morphology under different values of Oscillatory Shear Stress (OSI) in a flow chamber

    Hanif SAIFURRAHMAN, Zi WANG, 小島有紀子, 安西眸, 太田信

    日本機械学会 第33 回バイオフロンティア講演会

  27. 微小血管塞栓のための粒子付着を伴うCFD 解析

    後庵野大輔, 長谷川将大, 小黒草太, 高瀬圭, 津田俊幸, 安西眸, 太田信

    日本生体医工学会 東北支部大会

  28. Hemodynamics-based assessment of the Coronary Artery Aneurysm using Computational Fluid Dynamics

    Muhamed Albadawi, Yasser Abuouf, Ryuhei Yamaguchi, Hitomi Anzai, Makoto Ohta, Mahmoud Ahmed

    日本生体医工学会 東北支部大会

  29. Blood flow simulations in cerebrovascular models from BraVa database

    Yutaro Kohata, Méghane Decroocq, Carole Frindel, Makoto Ohta, Hitomi Anzai

    ELyT Workshop 2022

  30. Observation of Endothelial Cell Response to Various Stenting Deployment in an In-Vitro Flow System

    Hanif Saifurrahman, Zi Wang, Yukiko Kojima, Makoto Ohta, Hitomi Anzai

    ELyT Workshop 2022

  31. Introduction of Synthetic Artery Data

    Kazuyoshi Jin, Keiichiro Shiraishi, Ko Kitamura, Shunji Mugikura, Naoko Mori, Makoto Ohta, Hitomi Anzai

    ELyT Workshop 2022

  32. Geometrical Analysis of Standard Cerebrovascular Coordinates Invited

    Hitomi Anzai, Ko Kitamura, Naoko Mori, Shunji Mugikura, Makoto Ohta

    19th International Conference on Flow Dynamics

  33. Finite Element Analysis of Degradation Processes of Biodegradable Stents under the Action of Various Factors

    Hanbing Zhang, Shiliang Chen, Aike Qiao, Hongfang Song, Wenyu Fu, Hitomi Anzai, Makoto Ohta

    19th International Conference on Flow Dynamics

  34. Explore the Shaping Effects of Arteriovenous Fistula on Haemodynamics in Patients Receiving Haemodialysis

    Mingzi Zhang, Makoto Ohta, Itsu Sen, Yujie Li, Hitomi Anzai, Takeda Kazuki

    19th International Conference on Flow Dynamics

  35. Validity of Multivariate Normality Assumption for Data Augmentation on Artery Centerlines

    Kazuyoshi Jin, Ko Kitamura, Naoko Mori, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    19th International Conference on Flow Dynamics

  36. Virtual Angiography for Evaluation of Velocity Estimation Method

    Yutaro Kohata, Méghane Decroocq, Simon Ri, Carole Frindel, Makoto Ohta, Hitomi Anzai

    19th International Conference on Flow Dynamics

  37. Development of Open-Source Deployment Method for Simulation and Optimization of Balloon Angioplasty and Stent Geometry Design based on Numerical Simulation Invited

    Narendra Kurnia Putra, Mikha Hilliard, Muhammad Rafi Sudraja, Bonfilio Nainggolan, Makoto Ohta, Hitomi Anzai

    19th International Conference on Flow Dynamics

  38. ステント角度が細胞挙動に及ぼす影響

    小島有紀子, 王子,Narendra Kurnia Putra, 大津直史, 安西眸, 太田信

    2022年度 東北大学金属材料研究所共同研究ワークショップ 日本バイオマテリアル学会東北ブロック講演会

  39. Computational Fluid Dynamics Analysis on multi-bifurcation vascular model -Pial Arteriovenous Fistula with 11 outlets-

    Yutaro Kohata, Hitomi Anzai, Taichi Kin, Makoto Ohta

    18th Interdisciplinary Cerebrovascular Symposium

  40. INVESTIGATION OF THE INFLUENCE OF VASCULAR ACCESS SHAPE ON HEMODYNAMIC PARAMETERS Invited

    H. Anzai, K. Takeda, A. Kajiyama, M. Ohta

    The 13th Pacific Symposium on Flow Visualization and Image Processing

  41. Statistical Shape Model of aorta and carotid arteries by using relative coordinates

    Keiichiro Shiraishi, Meghane Decroocq, Makoto Ohta, Gaoyang Li, Haoran Wang, Carole Frindel, Hitomi Anzai

    15th World Congress on Computational Mechanics (WCCM-XV) & 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII)

  42. Generation of Virtual Patient Cerebral Arteries Focused on Geometric Feature Distributions Using Multivariate Normal Distribution

    Kazuyoshi, Jin, Ko Kitamura, Naoko Mori, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    15th World Congress on Computational Mechanics (WCCM-XV) & 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII)

  43. Angioscopy Visibilities for Stenotic Arteries using Computational Fluid Dynamics

    Daisuke Goanno, Kohei Mitsuzuka, Yujie Li, Mingzi Zhang, Kazunori Horie, Kazuki Takeda, Yutaro Kohata, Hitomi Anzai, Makoto Ohta

    15th World Congress on Computational Mechanics (WCCM-XV) & 8th Asian Pacific Congress on Computational Mechanics (APCOM-VIII)

  44. The Effect of Stent Angle on Flow and Endothelialization Process in a Parallel Chamber

    Yukiko Kojima, Zi Wang, Narendra Kurnia Putra, Naofumi Ohtsu, Hitomi Anzai, Makoto Ohta

    9th World Congress of Biomechanics

  45. ANGIOGRAPHY-BASED TIME-INTENSITY-CURVE ANALYSIS TO ESTIMATE IN-STENT HEMODYNAMICS

    Yutaro Kohata, Hitomi Anzai, Makoto Ohta

    7th International Conference on Computational & Mathematical Biomedical Enginnering

  46. PROPOSAL OF A NEW RELATIVE COORDINATES METHOD FOR CREATING STATISTICAL SHAPE MODEL OF AORTA AND CAROTID ARTERIES

    Keiichiro Shiraishi, Meghane Decroocq, Makoto Ohta, Gaoyang Li, Haoran Wang

    7th International Conference on Computational & Mathematical Biomedical Enginnering

  47. VERTEBRAL DOMINANCE AND BASILAR ARTERY

    F. Pan, N. Mori, S. Mugikura, H. Anzai, M. Ohta

    7th International Conference on Computational & Mathematical Biomedical Enginnering

  48. NUMERICAL MODELING OF DROPLET GENERATION INDUCED BY COUGH-FLOW IN IDEAL AIRWAY MODELS

    Hitomi Anzai, Yugo Shindo, Yutaro Kohata, Masahiro Hasegawa, Makoto Ohta

    7th International Conference on Computational & Mathematical Biomedical Enginnering

  49. Flow chamber for evaluation of Endothelial cell adhesion on stent struts Invited

    M. Ohta, Z. Wang, Y. Kojima, N. K. Putra, N. Ohtsu, H. Saifurrahman, H. Anzai

    Chemistry Physics and Biology of Colloids and Interfaces

  50. オイラー液膜モデルを用いた下気道壁面からの微小飛沫生成シミュレーション Invited

    安西眸

    日本機械学会バイオエンジニアリング部門 制御と情報-生体への応用-研究会　2022/01/18

  51. 数値流体解析を用いた気道内飛沫生成 シミュレーション Invited

    安西眸

    第4回 SDGs-ID 若手の会　2021/08/27

  52. オイラー液膜モデルを用いた下気道モデルの飛沫シミュレーション~第一報臨界せん断応力に関する検討~

    進藤有悟, 森奈緒子, 麦倉俊司, 赤池孝章, 松永哲郎, 太田信, 安西眸

    統計数理研究所・東北大学流体科学研究所・材料高等研究所合同ワークショップ　2021/04/21

  53. 脳血管確率アトラスに基づく脳血管自動ラベル付けプログラムの開発（第１報、中心線に基づく確率アトラスのラベル付け精度の評価）

    神 容慶, 北村 洸, 太田 信, 安西 眸, 麦倉 俊司, 森 菜緒子

    第54回 日本生体医工学会東北支部大会　2021/01/23

  54. A study on Optical Flow Method for Hemodynamics Estimation

    Yutaro Kohata, Hitomi Anzai, Makoto Ohta, Meghane Decroocq, Carole Frindel, Simon RIT

    2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020　2020/12/16

  55. The influence brought by specific boundary conditions on vascular simulations

    Fangjia Pan, Makoto Ohta, Hitomi Anzai, Shunji Mugikura, Naoko Mori

    2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020　2020/12/16

  56. CFD analysis of AVF for hemodialysis

    Kazuki Takeda, Hitomi Anzai, Mingzi Zhang, Kohei Mitsuzuka, Wang Haoran, Ai Kajiyama, Makoto Ohta

    2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020　2020/12/16

  57. Optimization of stent structure based on blood flow simulation Invited

    Hitomi Anzai, Mingzi Zhang, Narendra Kurnia Putra, Makoto Ohta

    2ND INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL BIOFLUID 2020　2020/12/06

  58. Implementation of Computer Simulation to Assess Flow−Diversion Treatment Outcomes— Systematic Review and Meta−Analysis Invited

    Mingzi Zhang, Simon Tupin, Hitomi Anzai, Yutaro Kohata, Massaki Shojima, Kosuke Suzuki, Yoshihiro Okamoto, Katsuhiro Tanaka, Takanobu Yagi, Soichiro Fujimura, Makoto Ohta

    17th Interdisciplinary Cerebrovascular Symposium (ICS 2020)　2020/10/30

  59. CFD Analysis of The Effect of Flush Flow Condition on Angiopscopy Visibility

    Kohei Mitsuzuka, Yujie Li, Toshio Nakayama, Hitomi Anzai, Wang Haoran, Makoto Ohta, Simon Tupin

    17th International Conference on Flow Dynamics　2020/10/30

  60. 生体組織モデルを用いた医療機器開発へ参加のお誘い Invited

    太田 信, Tupin Simon, 安西 眸, 于 凱鴻, Zhang Mingzi, 戸塚 厚, 小助川博之

    第61回 日本脈管学会総会　2020/10/13

  61. Implementation of Computer Simulation to Assess Flow−Diversion Treatment Outcomes — Systematic Review and Meta−Analysis Invited

    Mingzi Zhang, Simon Tupin, Hitomi Anzai, Yutaro Kohata, Massaki Shojima, Kosuke Suzuki, Yoshihiro Okamoto, Katsuhiro Tanaka, Takanobu Yagi, Soichiro Fujimura, Makoto Ohta

    2020/10/05

  62. Angiography-based velocimetry for blood flow

    Y. Kohata, H. Anzai, M. Decroocq, S. Rit, C. Frindel, Makoto Ohta

    Lyon Saint Etienne & Nippon Scientific Network Engineering sciences Lyon Tohoku LyonSE&N – ELyT Workshop 2020　2020/02/17

  63. Flow Characteristics of Wall Elasticity in a Full-Scale patient-Specific Middle Cerebral Aneurysm

    Gaku Tanaka, Nadia S. Shafii, Gaku Takizawa, Tomoaki Yamazaki, Simon Tupin, Hitomi Anzai, Kahar Osman, Ryuhei Yamaguchi, Makoto Ohta

    The Nineteenth International Symposium on Advanced Fluid Information (AFI-2019)　2019/11/07

  64. Influence of Input Patch Sizes on Results of a Convolutional Neural Network to Detect Cerebral Aneurysms from MRA Images

    Kazuhiro Watanabe, Hitomi Anzai, Norman Juchler, Sven Hirsch, Philippe Bijlenga, Makoto Ohta

    Sixteenth International Conference on Flow Dynamics　2019/11/07

  65. 畳み込みニューラルネットワークに基づくアテローム性動脈硬化症患者のパルスパターン認識

    Gaorang LI

    第29回バイオフロンティア講演会　2019/10/24

  66. Simulation research on hemodynamic of surgery of coronary artery aneurysm

    Haoran WANG

    2019/09/11

  67. Pulse pattern classification of atherosclerotic patients based on convolutional neural network

    2019/08/21

  68. Physical and Virtual Arterial Models with Mechanical Properties for Mechanical Testing of Medical Device

    Makoto Ohta, Yasutomo Shimizu, Kaihong Yu, Mingzi Zhang, Simon Tupin, Hitomi Anzai

    UTM-IFS 1st Workshop 2019　2019/08/21

  69. MRA 画像を用いた脳底動脈形状の標準化

    北村洸,麦倉俊司,太田信,安西眸

    第30回バイオフロンティア講演会　2019/07/19

  70. Computational Fluid Dynamics Analysis of Pial Arteriovenous Fistula

    Yutaro Kohata, Anzai Hitomi, Taichi Kin, Ohta Makoto

    6th International Conference on Computational and Mathematical Biomedical Engineering　2019/06/12

  71. 3D Structure Standardization Of Cerebral Artery Using MRA Images For Classificattion

    Ko Kitamura, Shunji Mugikura, Makoto Ohta, Hitomi Anzai

    6th International Conference on Computational and Mathematical Biomedical Engineering　2019/06/12

  72. Normalization of Basilar Artery Structure with MRA Images

    北村洸, 麦倉俊司, 太田信, 安西眸

    日本機械学会バイオフロンティア講演会講演論文集(CD-ROM)　2019

  73. 脳動脈瘤抽出用ニューラルネットワークにおける，入力画像の表現方法の違いによる判定精度への影響

    渡邉和浩

    第31回バイオエンジニアリング講演会　2018/12/15

  74. Hemodynamic Study on Coronary Artery Aneurysms with Bypass Surgery International-presentation

    Haoran WANG

    Fifteenth Internatinal Conference of Fluid Dynamics　2018/11/09

  75. PIV MEASUREMENT IN AN IDEAL ANEURYSMAL MODEL USING A TRANSPARENT COIL MODEL International-presentation

    OHTA Makoto

    Conference on Modelling Fluid Flow (CMFF’18) The 17th International Conference on Fluid Flow Technologies　2018/09/04

  76. Computational Fluid Dynamics Analysis to Predict Endothelial Cells Migration during Flow Exposure Experiment with Placement of Two Stent Wires International-presentation

    Narendra Kurnia Putra

    40th Annual International Conference of IEEE Engineering in Medicine and Biology Society　2018/07/17

  77. Ko Kitamura, Yujie Li, Mingzi Zhang, Hitomi Anzai, Shuji Mugikura, Makoto Ohta International-presentation

    KITAMURA Ko

    8th World Congress of Biomechanics　2018/07/08

  78. Multiobjective Optimization of Stent Design towards In-Stent Restenosis International-presentation

    Narendra Kurnia Putra

    8th World Congress of Biomechanics　2018/07/08

  79. Can morphology or haemodynamic characteristics of verteebrobasilar system be identifier of hypertension

    Ko Kitamura, Yujie Li, Mingzi Zhang, Hitomi Anzai, Shuji Mugikura, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  80. Characteristics of Elasticity on Flow Behavior in Middle Cerebral Aneurysm Model

    Ryuhei Yamaguchi, Gaku Tanaka, Taihei Kotani, Kahar Osman, Nadia Shafii, Hitomi Anzai, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  81. Dose hypertension history affect morphology or hemodynamic characteristics of Cerebrobasilar System? Retrospetive study of 249 patients diagnosed with hypertension.

    Yujie Li, Mingzi Zhang, Ko Kitamura, Hitomi anzai, Shuji Mugikura, Makoto Ohta

    8th World Congress of Biomechanics　2018/07

  82. PIV MEASUREMENT IN AN IDEAL ANEURYSMAL MODEL USING A TRANSPARENT COIL MODEL

    Makoto OHTA, Masanori KUZE, Simon TUPIN, Kaihong YU, Yasutomo SHIMIZU, Hitomi ANZAI

    Conference on Modelling Fluid Flow (CMFF’18)　2018/07

  83. An application of deep learning technique for neurovascular research and future diagnosis International-presentation Invited

    ANZAI Hitomi

    15th Interdisciplinary Cerebrovascular Symposium　2018/06/08

  84. 格子ボルツマン法を用いたステントストラット配置が脳動脈瘤流れに与える影響の解析

    渡邉 和浩

    第23回計算工学講演会　2018/06/06

  85. Correlation of CFD with enhancement International-presentation

    Hitomi Anzai, Norman Juchler, Makoto Ohta, Sven Hirsch, Philippe Bijlenga, Daniel A. Rüfenacht, Isabel Wanke

    international NeurovascularExploratoryWorkshop (iNEW)　2018/02/07

  86. Analysis of relationship between aneurysmal flow and stent struts by using the lattice Boltzmann method

    渡邉和浩, 安西眸, 太田信

    計算工学講演会論文集(CD-ROM)　2018

  87. Location related variability of permeability characteristics in cancellous bone

    Ito Makoto, Tupin Simon, Anzai Hitomi, Suzuki Anna, Ohta Makoto

    Proceedings of the 14th International Conference on Flow Dynamics　2017/11

  88. Automatic detection and localization of intracranial aneurysms by means of deep learning. International-presentation

    Kazuhiro Watanabe, Norman Juchler, Hitomi Anzai, Makoto Ohta, Sven Hirsch

    Deep Learning Day 2017　2017/09/22

  89. ANALYSIS OF OPTIMAL STENT STRUCTURE FOR FLOW STAGNATION USING SELF-ORGANIZING MAPS International-presentation

    Hitomi Anzai, Yuuki Yoshida, Makoto Ohta

    5th Switzerland-Japan Workshop on Biomechanics　2017/09/14

  90. ２D Vertex Model of Cell Monolayers and its Applications International-presentation

    Aziza Merzouki, Orestis Malasinas, Aurelien Roux, Anastasiya Trushko, Patrycja Paruch, Guillaume Rapin, Makoto Ohta, Hitomi Anzai, Athanasia Tzika, Mastien Chopard

    5th Switzerland-Japan Workshop on Biomechanics　2017/09/14

  91. HOW TO FIND OUT OPTIMAL INTERVAL OF STRUTS FOR CEREBRAL ANEURYSM? International-presentation

    Kazuhiro Watanabe, Hitomi Anzai, Makoto Ohta

    5th Switzerland-Japan Workshop on Biomechanics　2017/09/14

  92. 教育用、評価用、プレオペ用血管モデルの開発

    太田 信, 清水康智, 于 凱鴻, Simon Tupin, 安西 眸

    第53回日本医学放射線学会秋期臨床大会、特別企画「機能解析における数学的手法理解のために：数理分野と放射線科医の協働が織りなすハーモニー」　2017/09/10

  93. 海綿骨内における浸透率測定

    伊藤誠, Simon Tupin, 安西眸, 鈴木杏奈, 太田信

    第40回日本バイオレオロジー学会年会　2017/05/27

  94. 血管モデルの開発と動物実験

    太田 信, 大西泰平, Simon Tupin, 清水康智, 于 凱鴻, 安西 眸

    第64回日本実験動物学会総会、シンポジウム2「基盤的研究を医療現場に活かすための動物実験の役割」　2017/05/25

  95. Response Surface based Analysis to Improve the Intravascular Stent Design Performance on Optimizing Wall Shear Stress Conditions

    Narendra Kurnia Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    第56回日本生体医工学会大会　2017/05/03

  96. Where does CFD identify lesion instability in small aneurysms? International-presentation

    Hitomi Anzai, Norman Juchler, Sven Hirsch, Makoto Ohta, Daniel R ̈ufenacht, Isabel Wanke

    5th International Conference on Computational & Mathmatical Biomedical Engineering　2017/04/10

  97. Variation of strut parameter effects with wall deformation on stent International-presentation

    Narendra Putra, Pramudita Satria Palar, Hitomi Anzai, Koji Shimoyama, Makoto Ohta

    5th International Conference on Computational & Mathmatical Biomedical Engineering　2017/04/10

  98. EC migration analysis by CFD with a strut in flow chamber International-presentation

    Makoto Ohta, Tomohito Watanabe, Xiaobo Han, Hitomi Anzai

    5th International Conference on Computational & Mathmatical Biomedical Engineering　2017/04/10

  99. 流量計と圧力センサを組み込んだインビトロモデルによるマルチレイヤーステントの評価

    テュパン シモン, 清水康智, 安西眸, 太田信

    第29回バイオエンジニアリング講演会　2017/01/19

  100. Introduction of numerical simulation being applied to the study of aneurysm treatment with flow-diverting stent

    ZHANG Mingzi, LI Yujie, ANZAI Hitomi, SEN Itsu, OHTA Makoto

    The Proceedings of Mechanical Engineering Congress, Japan　2017

    More details Close

    <p>Intracranial aneurysms (IAs) account for a large portion of cerebrovascular disorders and can be treated with flow-diverting (FD) stents. To aid the treating clinicians with determination of a favourable treatment plan, we adopted numerical simulation methods to the optimisation of FD treatment, including the design optimisation of FD stent wire structure, as well as the optimisation of FD stent treatment procedure. Our simulation results suggest that both stent design and stent deployment may drastically affect the FD treatment outcomes; numerical simulation prior to the real treatment may therefore assist the treating clinicians in predicting the treatment outcomes.</p>

  101. 教育用,評価用,プレオペ用血管モデルの開発

    太田信, 清水康智, 于凱鴻, TUPIN Simon, 安西眸

    日本医学放射線学会秋季臨床大会抄録集　2017

  102. 脳動脈瘤の生化学的イベントと数値流体解析の応用に関するCutting-Edge

    安西眸, Mingzi Zhang, Narendra Kurnia Putra, 渡邉和浩, 太田信

    神経血管内治療学会，機械学会バイオエンジニアリング部問共同研究会「脳神経血管内治療に関する医工学連携研究会」国際頭蓋内ステント学会共同シンポジウム　2016/11/26

  103. Correlating MR Wall Enhancement and Wall Shear Stress: Does CFD work to predict aneurysm instability? International-presentation

    Hitomi Anzai, Norman Juchler, Makoto Ohta, Sven Hirsch, Daniel A. Rüfenacht, Isabel Wanke

    13th International IntraCranial Stent Meeting　2016/11/26

    More details Close

    Poster Award

  104. An Investigation on the Effect of Vessel Wall Deformation on Blood Flow and Wall Shear Stress along Stent Deployment Area International-presentation

    Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta

    13th International IntraCranial Stent Meeting　2016/11/26

  105. Exploring the relationship between the inflow zone and strut positions within the aneurysm orifice: a hemodynamic simulation study International-presentation

    Kazuhiro Watanabe, Hitomi Anzai, Makoto Ohta

    13th International IntraCranial Stent Meeting　2016/11/26

    More details Close

    Poster Award

  106. BioModels International-presentation

    Makoto Ohta, Kaihong Yu, Simon Tupin, Yuta Muramoto, Hitomi Anzai, Yasutomo Shimizu

    3rd Biomedical Science and Technology Symposium (Macquarie-Tohoku Symposium)　2016/11/09

  107. Stent Evaluation in vitro: Towards Next Generation of Biomodels International-presentation

    Simon TUPIN, Yasutomo SHIMIZU, Hitomi ANZAI, Kei TAKASE

    3rd Biomedical Science and Technology Symposium (Macquarie-Tohoku Symposium)　2016/11/09

  108. Hemodynamic Behaviors under Blood Vessel Deformation by Stent Struts: Two Dimensional Study. International-presentation

    Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta

    Thirteenth International Conference on Flow Dynamics　2016/10/10

  109. Comparison Study of Blood Flow Pattern Changes due to the Blood Vessel Deformation during Intravascular Stent Deployment International-presentation

    Narendra Kurnia Putra, Hitomi Anzai, Makoto Ohta

    TFC ELyT Workshop 2016　2016/10/06

  110. 流れ中における内皮化促進のための表面処理に関する研究

    渡邊知仁, 小林尚俊, 韓笑波, 安西眸, 太田信

    日本流体力学会年会2016　2016/09/26

  111. 血管内治療のための血管モデル開発

    太田 信, 清水康智, Simon Tupin, 大西泰平, 村元雄太, Joanna Seiller, 于 凱鴻, 安西 眸

    日本機械学会 2016 年度年次大会　2016/09/11

  112. 力学的、熱力学的機能性を付与した生体組織モデル（バイオモデル）の開発と応用

    太田 信, 于 凱鴻, Simon Tupin, 清水康智, 安西 眸

    第１２回東北大学 REDEEM シンポジウム　2016/09/10

  113. Introduction of a flow rate and pressure controlled in vitro model to evaluate stent deployment effects to blood flow

    Simon TUPIN, Yasumoto SHIMIZU, Hitomi ANZAI, Kei TAKASE, Makoto OHTA

    東北大学-信州大学共催シンポジウム　2016/08/03

  114. 低レイノルズ数領域における血液環流フローチャンバーシステムの開発

    安西眸, 白石泰之, 山家智之, 太田信

    第39回日本バイオレオロジー学会年会　2016/06/18

  115. AVEC CFD 2016

    安西眸, Simon Tupin, 渡邉 和浩, Sherif Rashad, 太田信

    第39回日本バイオレオロジー学会年会　2016/06/18

  116. 医療デバイス設計のための形状最適化とCFD

    第20回 流体科学におけるバイオ・医療に関する講演会　2016/06/15

  117. 医療デバイス設計のための形状最適化とCFD

    第20回 流体科学におけるバイオ・医療に関する講演会　2016/06/15

  118. Optimal Interval of two struts relative to aneurysm inflow International-presentation

    Hitomi Anzai, Kazuhiro Watanabe, Makoto Ohta

    VII European Congress on Computational Methods in Applied Sciences and Engineering　2016/06/05

  119. Distribution on Endothelial Cells Downstream of a Stent Strut: An In-vitro Study International-presentation

    Makoto Ohta, Tomohito Watanabe, Xiaobo Han, Hisatoshi Kobayashi, Hitomi Anzai

    VII European Congress on Computational Methods in Applied Sciences and Engineering　2016/06/05

  120. Endothelialization on NiTi wire with immobilization of collagen using HMDI International-presentation

    Tomohito Watanabe, Hisatoshi Kobayashi, Sho Matsumoto, Xiaobo Han, Hitomi Anzai, Makoto Ohta

    10th World Biomaterials Congress　2016/05/17

  121. 動脈瘤ネックの流入領域に対するストラットの相対位置が瘤内流れに与える影響

    渡邉 和浩, 安西 眸, 太田 信

    第28回バイオエンジニアリング講演会　2016/01/09

  122. 脳血管内治療デバイスと治療の有効性を予測する血管モデルの開発

    太田信, TUPIN Simon, 清水康智, 于凱鴻, 安西眸

    脳血管内治療(Web)　2016

  123. AVEC CFD2016

    安西眸, TUPIN Simon, 渡邉和浩, RASHAD Sherif, 太田信

    日本バイオレオロジー学会誌(Web)　2016

  124. Optimization of Flow Diverter design International-presentation

    Makoto Ito, Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    Beijing-Tohoku Biomechanics Symposium　2015/11/25

  125. Co-relationship between Hemodynamics and Optimal Stent Structure International-presentation

    Hitomi Anzai, Kazuhiro Watanabe, Yuuki Yoshida, Koji Shimoyama, Shigeru Obayashi, Makoto Ohta

    2nd Biomedical Symposium and 1st Biomedical Engineering Symposium　2015/11/16

  126. Towards the Patient-specific Design of Intracranial Stents for Advanced Flow Diversion Efficacy International-presentation

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    2nd Biomedical Symposium and 1st Biomedical Engineering Symposium　2015/11/16

  127. In-Vitro Model and Cell Behaviors International-presentation

    Makoto Ohta, Tomohito Watanabe, Xiaobo Han, Kaihong Yu, Taihei Onishi, Hitomi Anzai

    2nd Biomedical Symposium and 1st Biomedical Engineering Symposium　2015/11/16

  128. Visualization of Flow Patterns through the Aneurysmal Orifice after Flow Diverter Optimizations with Different Objective Functions International-presentation

    Zhang M, Anzai H, Ohta M

    Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)　2015/11/13

  129. Analysis of Relationship Between Stent Structure and Flow Stagnation Using Self-Organizing Maps for Realistic Aneurysm International-presentation

    Anzai H, Yoshida Y, Shimoyama K, Obayashi S, Ohta M

    Interdisciplinary Cerebrovascular Symposium (Intracranial Stent Meeting 2015)　2015/11/13

  130. Cell density distribution around the wire with flow condition International-presentation

    Tomohito Watanabe, Han Xiaobo, Makoto Ohta, Hitomi Anzai, Hisatoshi Kobayashi

    The Fifteenth International Symposium on Advanced Fluid Information　2015/10/27

  131. Development of a Program for Blood flow and Cell Behaviors Based on LBM Method (third report) International-presentation

    Makoto Ohta, Mingzi, Zhang, Bastien Chopard, Xiaobo Han, Yujie Li, Hitomi Anzai

    AFI-TFI　2015/10/27

  132. 医療機器の開発に向けた海綿骨内の数値流体力学解析

    佐久間航, 中山敏男, 安西眸, 中村修二, 佐渡克之, Konstantin Kucher, Martin Geier, Manfred Krafczyk, 太田信

    東北大学-信州大学共催シンポジウム　2015/10/22

  133. 平均および最大流速の最適脳動脈瘤用ステントデザイン

    張明子, 安西眸, 太田信

    流体力学会2015　2015/09/26

  134. CFD Alanyses for the flow in Cancellous Bone with LBM International-presentation

    Wataru Sakuma, Toshio Nakayama, Hitomi Anzai, Shuji Nakamura, Katsuyuki Sado, Konstantin Kutscher, Martin Geier, Manfred Krafczyk, Makoto Ohta

    The 8th Asian-Pacific Conference on Biomechanics　2015/09/16

  135. 脳動脈瘤治療用ステントにおける自己組織化マップを用いた最適形状解析

    安西眸, 吉田裕貴, 下山幸治, 大林茂, 太田信

    日本機械学会2015年度年次大会　2015/09/13

  136. Introduction of Optimization of Design using Combination of Lattice Boltzmann Method as CFD and Simulated Annealing for Reduction of Flow Speed International-presentation

    Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    1st NUAA-Tohoku University Joint Symposium on Fluid Science, Aerospace Engineering and Smart Structure Technology　2015/07/21

  137. Searching for valuable hemodynamic parameters for applying to optimization study International-presentation

    Hitomi Anzai, Yuuki Yoshida, Mingzi Zhang, Makoto Ohta

    9th European Solid Mechanics Conference (ESMC 2015)　2015/07/06

  138. Manufacture-Oriented Design Optimization for a Flow Diverter Stent Using Lattice Boltzmann Method and Simulated Annealing International-presentation

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    11th World Congress of Structural and Multidisciplinary Optimization (WCSMO-11)　2015/06/07

  139. CFDで何をみるのか，見えるのか AVEC CFD 2015

    安西眸, 下權谷祐児, 太田信

    第38回日本バイオレオロジー学会年会　2015/06/06

  140. Optimization of endovascular prosthesis for the treatment ofcerebral aneurysms International-presentation

    Makoto Ohta, Guy courbebaisse, Hitomi Anzai, Mingzi Zhang, Bastien Chopard, Yue zhang

    2015 ELyT lab Workshop,Feb18-21, 2015,Matsushima, Japan　2015/02/18

  141. CFDで何をみるのか,見えるのか AVEC CFD2015

    安西眸, 下權谷祐児, 太田信, 八木高伸, 高尾洋之, 河野健一, 庄島正明

    日本バイオレオロジー学会年会プログラム・抄録集　2015

  142. 脳動脈瘤内の血液凝固促進を目指したステントデザインの最適化

    吉田裕貴, 安西眸, 太田信

    第11回最適化シンポジウム2014　2014/12/12

  143. 実形状海綿骨内の数値流体力学解析

    佐久間航, 中山敏男, 安西眸, 中村修二, 佐渡克行, 高川浩和, 太田信

    第27回計算力学講演会　2014/11/22

  144. Automation of design optimization for intracranial stent

    First International Symposium for collaborative research between Tohoku University and Technische Universitat Braunschweig　2014/11/11

  145. A Development of Manufacture-oriented Optimization Strategy for Flow Diverter Stent based on Cylindrical Spirals International-presentation

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    Eleventh International Conference on Flow Dynamics　2014/10/08

  146. Development of a Program for Blood Flow and Cell Behaviors Based on LBM Method (Second report) International-presentation

    M. Ohta, S. Matsumoto, X. Han, B. Chopard, M. Zhang, Y. Li, Y. Yoshida, H. Anzai

    Eleventh International Conference on Flow Dynamics　2014/10/08

  147. Modeling of Cortical Bone and Bone Marrow International-presentation

    M. Ohta, W. Sakuma, Y. Muramoto, H. Anzai, T. Nakayama

    Eleventh International Conference on Flow Dynamics　2014/10/08

  148. Optimization of stent design for intracranial aneurysm International-presentation

    Hitomi Anzai, Yuuki Yoshida, Makoto Ohta

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　2014/09/01

  149. Development of Image Guided Minimal Invasive Treatments International-presentation

    Makoto Ohta, Sho Matsumoto, Xiaobo Han, Mingzi Zhang, Yujie Li, Kaihong Yu, Hitomi Anzai

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　2014/09/01

  150. An Optimization Method of FD Stent for Cerebral Aneurysm facing tne Stent Design and Manufacturing Needs International-presentation

    Mingzi Zhang, Hitomi Anzai, Bastien Chopard, Makoto Ohta

    The Fourth Japan-Switzerland Workshop on Biomechamics (JSB2014)　2014/09/01

  151. The concept of Bundle of Inflow (BOI) for reducing flow in aneurysm International-presentation

    Makoto Ohta, Hitomi Anzai, Mingzi Zhang, Yujie Li, Xiaobo Han, Kaihong Yu, Toshio Nakayama

    7th World Congress of Biomechanics (WCB2014)　2014/07/06

  152. Manufacture-oriented Struts Structure Optimization of Flow Diverter for Intracranial Aneurysm International-presentation

    Mingzi Zhang, Hitomi Anzai, Makoto Ohta

    7th World Congress of Biomechanics (WCB2014)　2014/07/06

  153. 脳動脈瘤治療用ステントにおける数値解析を用いた最適設計

    安西眸, Bastien Chopard, 中山敏男, 張明子, 吉田裕貴, 太田信

    第19回計算工学講演会　2014/06/11

  154. Analysis of optimized design of stent International-presentation

    Interdisciplinary Cerebrovascular Symposium, ICS2014　2014/06/02

  155. Introduction of Design Optimization for Intracranial Stent International-presentation

    Hitomi Anzai, Makoto Ohta

    2nd Core-to-Core Workshop "Japan-China Joint Workshop on Bio, Material and Flow Dynamics"　2014/02/27

  156. 血流数値解析に基づくステントデザインに関する研究

    信州大学・東北大学共催シンポジウム　2014/02/27

  157. ステントの最適デザインを考える

    太田信, 安西眸, 吉田裕貴, Mingzi Zhang, Yujie Li, 中山敏男

    脳神経外科速報　2014

  158. 血流低減のためのステント形状探索に関する研究

    産業技術総合研究所ライフサイエンス研究分野治療技術支援グループ研究セミナー　2013/12/18

  159. A Study on Multiscale Model in the presence of Systemic-to-Pulmonary Shunt utilizing LBM-LPM International-presentation

    M.Z.Zhang, H.Anzai, Y.J.Liu, M.Ohta

    The 5th Asia Pacific Congress on Computational Mechanics (APCOM2013)　2013/12/11

  160. Hemodynamic Numerical Simulation in Artery Complicated with both Stenosis and Aneurysm in Different Shape and Position International-presentation

    Y.J.Li, H.Anzai, T.Nakayama, Y.Shimizu, Y.Miura, A.K.Qiao M.Ohta

    The 5th Asia Pacific Congress on Computational Mechanics (APCOM2013)　2013/12/11

  161. Optimized Stent International-presentation

    Makoto Ohta, Hitomi Anzai, Toshio Nakayama, Xiaobo Han, Noriko Tomita

    Tenth International Conference on Flow Dynamics　2013/11/25

  162. Development of a Program for Blood flow and Cell Behaviors Based on LBM Method International-presentation

    Makoto Ohta, Bastien Chopard, Hitomi Anzai

    Tenth International Conference on Flow Dynamics　2013/11/25

  163. Optimization of stent design to increase the porosity International-presentation

    Yuuki Yoshida, Hitomi Anzai, Makoto Ohta

    12th Congress World Federation of Interventional and Therapeutic Neuroradiology　2013/11/09

  164. Optimization of blood flow for intracranial stent International-presentation

    Makoto Ohta, Hitomi Anzai, Han Xiaobo

    International Workshop on Flow Dynamics related to Energy, Aerospace and Material Processing　2013/09/10

  165. Application of optimization for design of intracranial stent with blood flow reduction as objective function International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    World Congress on Structural and Multidisciplinary Optimization　2013/05/19

  166. 血流低減を目的とした脳動脈瘤ステントデザインの最適設計

    太田信, 安西眸, 中山敏男

    第62回応用力学講演会　2013/03/06

  167. 実形状動脈瘤を用いたステント形状最適化プログラム開発に関する研究

    安西眸, Jean-Luc Falcone, Basten, Chopard, 太田信

    第25回バイオエンジニアリング講演会　2013/01/09

  168. Optimization of intracranial stent design for flow reduction

    Ohta Makoto, Anzai Hitomi, Nakayama Toshio

    NCTAM papers, National Congress of Theoretical and Applied Mechanics, Japan　2013

    More details Close

    The design optimization of stents (or flow diverters) from the view point of fluid dynamics has attracted attentions in recent years. However, the conventional optimization requires huge time and efforts to generate geometries and meshes. Therefore we have introduced the possibility to use lattice Boltzmann (LB) flow simulations in combination with simulated annealing (SA) optimization that explore the design of stents for 2-D aneurysms, in a fully automated way.This report demonstrates the optimization for 3-D aneurysm with two different objectives. As the result, optimum stent varies with the objectives.

  169. Optimal Design of Flow Diverter Stent Associated with Inflow ZonesStent designs for efficient reduction of intra-aneurismal flow with various aneurysms International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    GRADUATE SEMINAR SPONSORED BY: MECHANICAL ENGINEERING and MATERIALS SCIENCE　2012/10/11

  170. Flow analysis of stenosis and aneurysm using hydrogel for comparison to computational simulation International-presentation

    Makoto Ohta, Toshio Nakayama, Hitomi Anzai

    GRADUATE SEMINAR SPONSORED BY: MECHANICAL ENGINEERING and MATERIALS SCIENCE　2012/10/11

  171. Stent designs for efficient reduction of intra-aneurismal flow with various aneurysms International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    The 9th International IntraCranial Stent Meeting (ICS)　2012/10/08

  172. Modeling Flow Diverter Stent using Porous Media International-presentation

    Makoto Ohta, Yukihisa Miura, Hitomi Anzai, Toshio Nakayama

    The 9th International IntraCranial Stent Meeting (ICS)　2012/10/08

  173. 医療デバイス周りの血流流体力学的見地からの血栓形成

    太田信, Stephan G. Wetzel, 安西眸, 中山敏男, 韓笑波, 清水康智, 小澤桂, 冨田典子

    日本バイオマテリアル学会大会シンポジウム2012　2012/09/26

  174. Characterization of Design of Stent Strut Positioning using LBM Method International-presentation

    Makoto Ohta, Bastien Chopard, Hitomi Anzai

    the Twelfth International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI)　2012/09/19

  175. Measurement of Pressure Drop for Modeling Intracranial Flow Diverter Stent Using Porous Medium International-presentation

    Yukihisa Miura, Hitomi Anzai, Toshio Nakayama, Toshiyuki Hayase, Makoto Ohta

    Ninth International Conference on Flow Dynamics　2012/09/19

  176. Measurement of Pressure Drop for Modeling Intracranial Flow Diverter Stent Using Porous Medium International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    Optimum Design of Flow Diverter Stent Associated with Arterial Geometries　2012/09/19

  177. Simulation of Hemodynamics in Artery with Aneurysm and Stenosis International-presentation

    Yujie Li, Hitomi Anzai, Toshio Nakayama, Yasutomo Shimizu, Yukihisa miura, Aike Qiao, Makoto Ohta

    Optimum Design of Flow Diverter Stent Associated with Arterial Geometries　2012/09/19

  178. A Development of Lattice Boltzmann Model and Lumped Parameter Model Connection for Cardiovascular Multiscale Analysis International-presentation

    Mingzi Zhang, Hitomi Anzai, Youjun Liu, Makoto Ohta

    Optimum Design of Flow Diverter Stent Associated with Arterial Geometries　2012/09/19

  179. 脳動脈瘤に対するステントストラット位置の自動最適化に関する研究

    安西眸, Jean-Luc Falcone, Basten, Chopard, 太田信

    日本機械学会2012年度年次大会　2012/09/09

  180. Optimization of Intracranial Stent for Rducing Flow Using Lattice Boltzmann Method International-presentation

    Makoto Ohta, Hitomi Anzai

    2012 Beijing International Symposium on Biomechanics　2012/09/03

  181. The Design Characteristics Extracted from an Optimal Flow Diverter in an Ideal Side-wall Aneurysm Using Lattice Boltzmann Method International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    8th European Solid Mechanics Conference　2012/07/09

  182. 脳動脈瘤用フローダイバータステントモデル化に対する圧力勾配と瘤内流れに関する研究

    三浦幸久, 安西眸, 中山敏男, 太田信

    日本機械学会東北支部第47期総会・講演会　2012/03/13

  183. 格子ボルツマン法を用いた脳動脈瘤治療用ステントの形状最適化プログラムの開発

    安西眸, Jean-Luc Falcone, Basten, Chopard, 太田信

    日本機械学会第24回バイオエンジニアリング講演会　2012/01/07

  184. Effect of Initial Conditions of Stent Geometry on Optimized Design of Flow Diverters International-presentation

    Hitomi Anzai, Jean-Luc Falcone, Bastien Chopard, Makoto Ohta

    the Eleventh International Symposium on Advanced Fluid Information and Transdisciplinary Fluid Integration (AFI/TFI)　2011/11/09

  185. Visualization leads Endovascular Treatments of Cerebral Aneurysm

    Makoto Ohta, Hitomi Anzai, Yasutomo Shimizu, Shuya Shida, Kei Ozawa, Cahang -ho Yu, Hiroyuki Kosukegawa, Xiaobo Han, Noriko Tomita, Toshio Nakayama

    2011年度 上智大学理工学部 日本SGI株式会社寄付講座 「ビジュアリゼーション(科学技術における応用)II」　2011/10/20

  186. Development of the design of flow diverters using automated optimization based on lattice Boltzmann method International-presentation

    Hitomi Anzai, Makoto Ohta, Jean-Luc Falcone, Bastien Chopard

    8th International Interdisciplinary cerebrovascular Symposium and 11th Oriental Conference of Interventional Neuroradiology and 6th East Asian Conference of Neurointervention　2011/09/08

  187. Study on Effect of Blood Flow Reducing by Stent International-presentation

    Yukihisa Miura, Toshio Nakayama, Hitomi Anzai, Makoto Ohta

    8th International Interdisciplinary cerebrovascular Symposium and 11th Oriental Conference of Interventional Neuroradiology and 6th East Asian Conference of Neurointervention　2011/09/08

  188. 未破裂脳動脈瘤の破裂リスクに関する3次元可視化システムを用いたCFD解析の試み

    入江恵子, 太田信, 安西眸, 中山敏男, 根來真, 廣瀬雄一

    第34回日本バイオレオロジー学会年会　2011/06/03

  189. Porous Mediumを用いた脳動脈瘤用フローダイバータステントのモデル化に関する検証

    三浦幸久, 中山敏男, 安西眸, 太田信

    第７回生体工学と流体工学に関するシンポジウム　2011/03/03

  190. 未破裂脳動脈瘤の破裂リスクに関する３次元可視化システムを用いた経時的なCFD解析の試み

    入江恵子, 根來 眞, 太田 信, 中山敏男, 安西眸, 廣瀬雄一, 松井俊和

    第40回日本神経放射線学会　2011/02/24

  191. 未破裂脳動脈流の破裂リスクに関する３次元可視化システムを用いた経時的なCFD解析の試み

    入江恵子, 太田信, 中山敏男, 安西眸, 廣瀬雄一, 松井俊和

    第34回日本脳神経CI学会総会　2011/02/04

  192. 血流数値解析の3次元可視化による効果的な脳動脈瘤ステント配置の予想

    安西眸, 中山敏男, 入江恵子, 太田信

    日本機械学会, 第23回バイオエンジニアリング講演会　2011/01/08

  193. 8F-15 Prediction of effective position for intracranial stent using 3D visualization of numerical analysis of blood flow

    ANZAI Hitomi, NAKAYAMA Toshio, IRIE Keiko, OHTA Makoto

    The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME　2011

  194. フローダイバーターの脳動脈瘤ステント設計

    太田信, 安西眸, 中山敏男, Chang-ho Yu

    SMAシンポジウム2010　2010/11/26

  195. Numerical analisys of blood flow around intracranial stent using 3-d visualization International-presentation

    Hitomi Anzai, Toshio Nakayama, Keiko Irie, Makoto Ohta

    Swiss-Japanese Scientific seminar　2010/11/15

  196. The Effect of Computational Simulation on Endovascular Treatments of Cerebral Aneurysm

    Makoto Ohta, Kenjiro Okuno, Hitomi Anzai, Toshio Nakayama

    2010年度 上智大学理工学部総合講座「ビジュアリゼーション(科学技術における応用)II」　2010/11/04

  197. Analyzing Blood Flow in Bifurcated Artery with Cerebral Aneurysm using Two Stents International-presentation

    Hitomi Anzai, Toshio Nakayama, Keiko Irie, Makoto Ohta

    Seventh International Conference on Flow Dynamics　2010/11/01

  198. 黄色ブドウ球菌γヘモリジンが形成するヘテロヘプタマー膜孔複合体におけるサブユニット配置解析 Subunit arrangement analysis of staphylococcal γ-hemolysin heteroheptameric transmembrance pore

    Noriko Tomita, Kazuyo Abe, Hitomi Anzai, Makoto Ohta

    日本生物物理学会 第48回年会　2010/09/20

  199. Computational Design of Intracranial Stent Using 3D Visualization System International-presentation

    Makoto Ohta, Hitomi Anzai, Toshio Nakayama

    Live International Neuroradiology Conference (Inconjunction with the 7th ICS)　2010/08/13

  200. Analysis of Three-Dimensional Structure and Subunit Mismatch in Staphylococcal γ-Hemolysin Heteroheptameric Transmembrane Pore International-presentation

    Noriko Tomita, Hitomi Anzai, Kazuyo Aba, Makoto Ohta

    Microscopy and Microanalysis　2010/08/01

  201. Molecular Architecture Analysis of Staphylococcalγ-hemolysin Heteroheptameric Transmembrane Pore: Construction of Three-dimensional Structure with Subunit Arrangement Mismatch Based on High-resolution Electron Microscopic Image International-presentation

    Noriko Tomita, Hitomi Anzai, Kazuyo Aba, Makoto Ohta

    6th World Congress of Biomechanics　2010/08/01

  202. Simulations of Endovascular Treatment for Cerebral Aneurysm International-presentation

    Makoto Ohta, Kaoru Matsumoto, Syuya Shida, Chihaya Kiyomitsu, Hiroyuki Kosukegawa, Noriko Tomita, Chang-ho Yu, Hitomi Anzai, Toshio Nakayama, Anne M. Robertson

    6th World Congress of Biomechanics　2010/08/01

  203. 脳動脈用ステントにおける流体力学的理論解析の試み

    太田信, 安西眸, 中山敏男

    第16回日本血管内治療学会総会　2010/07/23

  204. Computational Simulation of Intracranial Stent using 3D visualization system International-presentation

    Makoto Ohta, Hitomi Anzai, Toshio Nakayama

    SIRIC International Symposium 2010　2010/07/02

  205. ブドウ球菌の2成分性毒素γヘモリジン膜孔複合体における分子配置解析と立体構造予測

    ブドウ球菌の, 成分性毒素, ヘモリジン膜孔複合体における分子配置解析と立体構造予測

    日本顕微鏡学会 第66回学術講演会　2010/05/23

  206. ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロヘプタマー膜孔複合体の立体構造とサブユニット間配置の定量的解析

    冨田典子, 安西眸, 阿部和代, 金子淳, 神尾好是, 太田信

    日本農芸化学学会2010年度大会　2010/03/28

  207. ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロヘプタマー膜孔複合体の立体構築とサブユニット間配置の定量的解析

    冨田典子, 安西眸, 阿部和代, 金子淳, 神尾好是, 太田信

    日本農芸化学会大会講演要旨集　2010

  208. Three-dimensional structure analysis of staphylococcal γ-hemolysin heteroheptameric transmembrance pore complex

    Noriko Tomita, Hitomi Anzai, Yoshiyuki Kamio, Makoto Ohta

    日本生物物理学会第47回年会講演　2009/10/31

  209. ブドウ球菌の2成分性毒素γヘモリジンが形成するヘテロへプタマー膜孔複合体の立体構造解析

    冨田典子, 安西眸, 金子淳, 神尾好是, 太田信

    日本ブドウ球菌研究会　2009/09/17

  210. 3次元可視化装置を用いた脳動脈瘤ステント周りの血流数値解析の可視化

    安西眸, 竹島由里子, 中山敏男, 太田信

    日本機械学会 2009年度年次大会　2009/09/13

  211. 3D Visualization of Numerical Simulation of Blood Flow on Intracranial Stent

    Hitomi Anzai, Yuriko Takeshima, Toshio Nakayama, Makoto Ohta

    Third Switzerland-Japan workshop on Biomechanics 2009(SJB 2009)　2009/09/01

  212. Molecular architecture analysis of Staphylococcal γ-hemolysin heteroheptameric transmembrane pore complex

    Noriko Tomita, Hitomi Anzai, Jun Kaneko, Yoshiyuki Kamio, Makoto Ohta

    Third Switzerland-Japan workshop on Biomechanics 2009(SJB 2009)　2009/09/01

  213. 3rd Virtual Intracranial Stenting Challenge(VICS09) International-presentation

    Makoto Ohta, Toshio Nakayama, Hitomi Anzai, Juan R. Cebral, Luca Augsburger

    International Intracranial Stent Meeting 2009: Virtual Intracranial Stent Challnege 2009　2009/08/05

  214. 3D Visualization of numerical simulation of blood flow on intracranial stent

    Hitomi Anzai, Yuriko Takeshima, Toshio Nakayama, Makoto Ohta

    International Intracranial Stent Meeting 2009　2009/08/05

  215. 黄色ブドウ球菌の2成分血球崩壊毒素γヘモリジンが形成する膜孔複合体の立体構造解析

    冨田典子, 安西眸, 金子淳, 神尾好是, 太田 信

    日本顕微鏡学会第65回学術講演会　2009/02/21

  216. 3D visualization of numerical simulation of blood flow on intracranial stent

    安西眸, 竹島由里子, 中山敏男, 太田信

    日本機械学会年次大会講演論文集　2009

    More details Close

    The effect of stent on the flow reduction in cerebral aneurysm has been reported in CFD studies showing the stent position or the strut shape may affect the flow reduction. The 3D visualization may help easily to specify the inlet zone from parent artery to aneurysm and to find the relationship between the effective strut position and the flow pattern. Then we simulated adding a strut to a stent model on the inlet zone after specifying the zone using 3D visualization system. After moving the strut and repeating the visualization of results, we found a strut on the zone may reduce the flow into aneurysm effectively. The results may suggest the 3D visualization is useful for the assessment of strut position with effective reduction of flow into aneurysm.

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Research Projects 14

  1. Effect of wall elasticity on hemodynamics inside patient-specific cerebral aneurysm

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  2. Establishment of a prediction model for aneurysm development by mathematical vascular branching pattern classification and vascular travel standardisation.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  3. 脳形態画像に基づく3次元血流場推定ネットワークの開発

    安西 眸, 麦倉 俊司, 杉山 慎一郎, 森 菜緒子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  4. 血流解剖に基づく未破裂脳動脈瘤分類および新規画像診断システムの提案

    杉山 慎一郎, 新妻 邦泰, 安西 眸, 船本 健一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  5. Visualization of stroke risk using standard model of MRA vascular course and wall stress

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  6. Development of the implant for the reduction of vascular stenosis of AV fistula of hemodialysis patients

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2021/04/01 - 2024/03/31

  7. Study of Structural and Thermal Properties of PVA as 3D Printing Material for Body Parts Modeling

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  8. Characteristics of elasticity on suppression for progress and rupture in cerebral aneurysm

    yamaguchi ryuhei

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

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    Mechanisms underlying growth and rupture of aneurysms are poorly understood. Although wall shear stress (WSS) in elastic aneurysms is examined using fluid structure interaction, it has not been sufficiently validated using experimental modalities, such as particle image velocimetry (PIV) or phase contrast magnetic resonance imaging. We investigated pulsatile flow in elastic patient-specific cerebral aneurysm using PIV. Phantom model was carefully fabricated using a specialized technique by silicone. We explored WSS and kinetic energy cascade (KEC) in elastic compared with a rigid models, at apex of bifurcation of middle cerebral artery in vitro. Effects of elasticity on WSS, WSS gradient, and tensile strength of aneurysm wall were also investigated, in addition to effect of wall elasticity on KEC compared to a rigid wall. Although WSSG around stagnation point had a large positive value, wall elasticity suppressed WSS magnitude around stagnation point and attenuated KEC.

  9. 飛沫発生シミュレーションによる新型コロナオ ミックス予測の開発 -新型コロナオミックスと サブミクロン流体力学を基盤としたエアロゾル 飛沫及び吸着シミュレーションの開発-

    安西 眸, 高奈 秀匡, 早川 晃弘, 大林 茂, 太田 信, 赤池 孝章, 松永 哲郎

    Offer Organization: 三菱総合研究所

    System: ポストコロナ時代の実現に向けた主要技術の実証・導入に係る事業企画

    Institution: 東北大学 流体科学研究所

    2021/09 - 2022/03

  10. CFD analysis on MR enhanced wall for investigation of mechanism of aneurysm instabiity Competitive

    ANZAI HITOMI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    This study aims to correlate the wall enhancement in MR vessel wall imaging and hemodynamic stress in small-middle cerebral aneurysms. In the case of 10-years follow-up, the extension of aneurysm wall occurs near the breb where the wall enhancement observed. For further study to establish the threshold of hemodynamic parameters, analysis for big data will be required. Therefore, deep learning technique was applied for predicting the flow field inside blood vessels. This network can predict the flow from the geometry directly and achieved the speedup of analysis 600 times than conventional CFD.

  11. Development of new stent for the treatment of intracranial fusiform aneurysms to cure the aneurysmal wall and preserve perforators

    Endo Hidenori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Using the data obtained from the human cases, we performed computational fluid dynamics (CFD) analysis. We calculated wall shear stress, oscillating shear index, relative residence time of the aneurysm to standardize these parameters. Then, We calculated the appropriate condition to cure the pathology of the aneurysmal wall and to preserve the perforators based on the theory of fluid engineering. We developed the design of the stent which can meet above mentioned condition based on the CFD data. We tried to create prototype stent to deploy into the aneurysm animal model to validate the proper design of the stent.

  12. Searching for a valid hemodynamic parameters for thrombus formation around intracranial stent

    Anzai Hitomi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2014/08/29 - 2016/03/31

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    The aim of this study is to clarify the relationship between hemodynamic parameters and thrombus formation around medical implants. We developed in vitro system with cavity flow chamber for goat blood. This system can develop the flow environment under low Reynolds number <100 observed in human brain aneurysm. We also performed cell experiment with NiTi metallic wire. The results show inhomogeneous cell distribution depending on surface treatment of wire and wire structure.

  13. 科学研究費助成事業 Competitive

    安西 眸

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業(研究活動スタート支援)

    2014/04 - 2016/03

  14. 脳動脈瘤治療用ステントの形状最適化法の開発

    安西 眸

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2011 - 2013

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    当該年度はこれまでに開発を行ってきたステント形状最適化プログラムを実形状動脈瘤に対して適用し, 瘤内平均流速を目的関数とした際の最適ステント形状の算出を行った. 実形状動脈瘤では, 親血管の曲がり・捻じれによって発生する局所的な動脈瘤への流入(Bundle of Inflow, BOI)が観察されており, 最適ステント形状は, このBOI部にストラットが集中する形状となった. ステントの多孔率(ストラットの本数)を変化させ最適化を行い, 先行研究として行ってきた3次元可視化による最適ストラット位置の推定と比較を行ったところ, どちらのストラットもBOI内部に分布し, さらにはそのストラットによる瘤内の血流低減率も良い一致を示した. 最適化プログラムでは, 形状探索のために200形状を用いて数値解析を行っているが, 3次元可視化を用いた方法では2通りの数値解析のみで効果的なストラット位置を探索でき, したがって, これら2つの手法を組み合わせることで, 最適ステントを求めるために要する時間を劇的に短縮することが可能であると示唆される. 近年では動脈瘤治療や破裂予測のため, 動脈瘤形状を分類し, データベース化する研究が行われている. そこで, 瘤形状の分類に従い, ステント形状も分類し対応付けることで, 新しい医療デバイス設計に関する知見が得られる可能性が示唆された. 当該年度は, 本研究に関する研究で2本の雑誌投稿論文が採択されており, また翌年度にはステントの多孔率と最適化前後の血流低減率に関する論文を投稿予定である.

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Media Coverage 5

  1. COVID-19陽性者搬送車内の気流を可視化 ～ドライバーをウイルスから守る～

    khb東日本放送　チャージ！

    2022/02/15

    Type: TV or radio program

  2. COVID-19陽性者搬送車内の気流を可視化 ～ドライバーをウイルスから守る～

    仙台放送　Live news イット！

    2022/02/09

    Type: TV or radio program

  3. 飛沫の伝わり方予測、東北大が開発 せき直前の喉の動きをAI解析

    河北新報 ONLINE NEWS

    2021/11/19

    Type: Internet

  4. せきを画像から予測 東北大、瞬時の感染防御に

    日本経済新聞

    2021/11/12

    Type: Internet

  5. 冠動脈の流れ瞬時に予測

    日経産業新聞　日経産業新聞

    2021/03/08

    Type: Newspaper, magazine

Academic Activities 1

  1. JOURNAL OF FLUID SCIENCE AND TECHNOLOGY 編集委員

    Activity type: Peer review

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    編集委員

Other 2

  1. ex vivo measurement and numarical analysis of heat propagation during steam ablation

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    As a new targeted, focal treatment of prostate cancer, we evaluate the potential use of steam ablation. To avoid undesirable side-effect, it is important to ablate only cancerous tissue. In this project, computational simulation is used to evaluate thermal propagation around medical devices and to optimize the methodology of steam ablation.

  2. １． 差圧方式高速応答微少流量計の流路最適化研究

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    申請者が独自に開発した最適化プログラムに注目され、次世代高速チップマウンター用の高速応答微少流量計の開発に必要な基礎データの収集を行った。本成果は次世代流量計の開発方向性を決める一因として用いられた。