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Kazuaki Tokodai

Section

Tohoku University Hospital

Job title

Associate Professor

Degree

researchmap

https://researchmap.jp/7000017774

J-GLOBAL ID

201601000990542175

Research History 3

2022/07 - Present

東北大学病院　臓器移植医療部　准教授
2021/04 - 2022/06

Tohoku University
2018/04 - 2021/03

東北大学病院　総合外科　助教

Education 2

Tohoku University Graduate School

2006/04 - 2010/03
Tohoku University

1997/04 - 2003/03

Committee Memberships 3

日本臨床腎移植学会　評議員

2018/02 - Present
日本肝胆膵外科学会　評議員

2015/06 - Present
日本膵・膵島移植研究会　実務者委員

2014/12 - Present

Professional Memberships 12

THE JAPANESE SOCIETY FOR ORGAN PRESERVATION AND BIOLOGY

2018/06 - Present
JAPANESE SOCIETY OF CLINICAL RENAL TRANSPLANTATION

2014/01 - Present
THE JAPAN SOCIETY OF HEPATOLOGY

2013/09 - Present
JAPAN SOCIETY FOR ENDOSCOPIC SURGERY

2013/06 - Present
JAPANESE SOCIETY OF HEPATO-BILIARY-PANCREATIC SURGERY

2012/11 - Present
JAPANESE SOCIETY OF GASTROENTEROLOGY

2010/07 - Present
The Transplantation Society

2010 - Present
THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY

2005/05 - Present
JAPAN SURGICAL SOCIETY

2003/06 - Present
日本肝移植学会
JAPANESE SOCIETY OF TISSUE TRANSPLANTATION
THE JAPAN SOCIETY FOR TRANSPLANTATION

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Research Interests 6

regenerative medicine
kidney transplantation
amnion cell
transplant immunology
hepatocyte transplantation
liver transplantation

Research Areas 2

Life sciences / Digestive surgery /
Life sciences / General surgery, pediatric surgery / transplantation

Awards 1

The Young Investigator Award

2010/08　International Congress of the Transplantation Society

Papers 244

Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand. International-journal Peer-reviewed

Ming Yao, Masaaki Watanabe, Sune Sun, Kazuaki Tokodai, Anthony Cerami, Michael Brines, Claes-Göran Östenson, Bo-Göran Ericzon, Torbjörn Lundgren, Makiko Kumagai-Braesch

Transplantation　104　(10)　2048-2058　2020/10

DOI： 10.1097/TP.0000000000003284 　

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BACKGROUND: During intraportal pancreatic islet transplantation (PITx), early inflammatory reactions cause an immediate loss of more than half of the transplanted graft and potentiate subsequent allograft rejection. Previous findings suggest that cibinetide, a selective innate repair receptor agonist, exerts islet protective and antiinflammatory properties and improved transplant efficacy in syngeneic mouse PITx model. In a stepwise approach toward a clinical application, we have here investigated the short- and long-term effects of cibinetide in an allogeneic mouse PITx model. METHODS: Streptozotocin-induced diabetic C57BL/6N (H-2) mice were transplanted with 320 (marginal) or 450 (standard) islets from BALB/c (H-2) mice via the portal vein. Recipients were treated perioperative and thereafter daily during 14 d with cibinetide (120 µg/kg), with or without tacrolimus injection (0.4 mg/kg/d) during days 4-14 after transplantation. Graft function was assessed using nonfasting glucose measurements. Relative gene expressions of proinflammatory cytokines and proinsulin of the graft-bearing liver were assessed by quantitative polymerase chain reaction. Cibinetide's effects on dendritic cell maturation were investigated in vitro. RESULTS: Cibinetide ameliorated the local inflammatory responses in the liver and improved glycemic control immediately after allogeneic PITx and significantly delayed the onset of allograft loss. Combination treatment with cibinetide and low-dose tacrolimus significantly improved long-term graft survival following allogeneic PITx. In vitro experiments indicated that cibinetide lowered bone-marrow-derived-immature-dendritic cell maturation and subsequently reduced allogeneic T-cell response. CONCLUSIONS: Cibinetide reduced the initial transplantation-related severe inflammation and delayed the subsequent alloreactivity. Cibinetide, in combination with low-dose tacrolimus, could significantly improve long-term graft survival in allogeneic PITx.
Effects of re-augmenting maintenance immunosuppression on post-transplant donor-specific HLA antibodies in liver transplantation. International-journal Peer-reviewed

Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Masafumi Goto, Michiaki Unno, Takashi Kamei

Transplant immunology　63　101334-101334　2020/09/09

DOI： 10.1016/j.trim.2020.101334 　

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BACKGROUND: Donor-specific antibodies (DSAs) have various negative short- and long-term effects after organ transplantation. DSAs are prevalent in patients with insufficient immunosuppression; thus, even patients with stable conditions after liver transplantation should be under optimized immunosuppression. However, the effect of re-augmenting immunosuppression therapy for patients with insufficient immunosuppression remains unclear. In this study, we investigated the long-term changes and the effects of immunosuppression (IS) re-augmentation on the DSA status. METHODS: Two DSA screenings were performed in 67 patients during long-term follow-up after liver transplantation. After the first screening, IS re-augmentation was performed in patients with consent. The effects of IS re-augmentation on the DSA status were analyzed using data of the serial DSA screenings. Negative conversion was defined as DSA positivity with MFI > 1000 converted to MFI < 1000. Improvement of DSA status was defined as either a 50% reduction of MFI or negative conversion. RESULTS: The median interval between the first and second DSA screening was 50 months. Among 67 patients, 43 were positive for DSAs on the first screening. Among these 43 patients, 30 had minimal to no IS therapy at the time of the first screening. Among the 30 patients, IS re-augmentation was conducted in 19. A comparison between the patients with a re-augmented IS and those with a sustained minimized IS showed that the DSA levels significantly decreased in the former (63% (12/19) vs. 18% (2/11), p = 0.02). CONCLUSIONS: The results of this study indicate that post-liver transplant IS re-augmentation had suppressive effects on the DSA status. However, the clinical significance of DSA-negative conversion and/or mean fluorescence intensity reduction needs to be further investigated through histological evaluation and/or graft survival during longer follow-up periods.
Association of post-reperfusion syndrome and ischemia-reperfusion injury with acute kidney injury after liver transplantation. International-journal Peer-reviewed

Kazuaki Tokodai, Claudia Lannsjö, Felicia Kjaernet, Antonio Romano, Anna Januszkiewicz, Bo-Göran Ericzon, Greg Nowak

Acta anaesthesiologica Scandinavica　2020/02/05

DOI： 10.1111/aas.13556 　

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BACKGROUND: Acute kidney injury (AKI) is frequently observed after orthotopic liver transplantation (OLT) even in patients with previously normal renal function. In this study, we investigated the impact of factors such graft steatosis, post-reperfusion syndrome (PRS), and hepatic ischemia reperfusion injury (HIRI) on the development of AKI after OLT in adult patients. METHODS: We retrospectively examined consecutive adult patients who underwent OLT at our institution between July 2011 and June 2017. AKI was diagnosed based on the criteria proposed by the International Kidney Disease Improving Global Outcomes (KDIGO) workgroup. Peak aspartate aminotransferase (AST) level within 72 hours after OLT was used as a surrogate marker for HIRI. Graft steatosis was diagnosed by histopathological examination using specimens biopsied intraoperatively at the end of transplantation procedure and categorized as <10%, 10%-20%, 20%-30%, and ≥30% of hepatic steatosis. RESULTS: Out of 386 patients, 141 (37%) developed AKI (KDIGO stage 1:71 patients; stage 2:29 patients; stage 3:41 patients). Multivariable logistic regression analysis revealed that cold ischemic time (P = .012) and HIRI (P = .007) were independent risk factors for post-OLT AKI. Multivariable analysis also revealed that graft steatosis was associated with HIRI but not directly with AKI. PRS was not associated with HIRI or AKI in the multivariable analyses. CONCLUSION: Our results indicate that greater severity of liver graft injury during transplantation negatively affects renal function after OLT. As expected, the severity of liver graft steatosis contributes to accelerated liver injury occurring during the transplantation procedure.
Blood Group Antigen Expression in Isolated Human Liver Cells in Preparation for Implementing Clinical ABO-Incompatible Hepatocyte Transplantation Peer-reviewed

Kazuaki Tokodai, Makiko Kumagai-Braesch, Ahmad Karadagi, Helene Johansson, Nils Agren, Carl Jorns, Bo-Goran Ericzon, Ewa Ellis

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY　2019/09
Characteristics and risk factors for recurrence of nonalcoholic steatohepatitis following liver transplantation. Peer-reviewed

Tokodai K, Karadagi A, Kjaernet F, Romano A, Ericzon BG, Nowak G

Scandinavian journal of gastroenterology　1-7　2019/04

DOI： 10.1080/00365521.2019.1577484 　

ISSN： 0036-5521
Association of post-transplant donor-specific HLA antibody with liver graft fibrosis during long-term follow-up after pediatric liver transplantation Peer-reviewed

Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Koji Miyazawa, Kenji Shimizu, Keigo Murakami, Hironobu Sasano, Masafumi Goto, Michiaki Unno, Takashi Kamei

Pediatric Transplantation　22　(3)　e13169　2018/05/01
Publisher: Blackwell Publishing Inc.
DOI： 10.1111/petr.13169 　

ISSN： 1399-3046 1397-3142
The effects of short-term subnormothermic perfusion after cold preservation on liver grafts from donors after circulatory death: An ex vivo rat model Peer-reviewed

Yuta Kakizaki, Shigehito Miyagi, Kenji Shimizu, Koji Miyazawa, Wataru Nakanishi, Kazuaki Tokodai, Yasuyuki Hara, Chikashi Nakanishi, Michiaki Unno, Takashi Kamei, Masafumi Goto, Susumu Satomi

Transplantation　102　(4)　e147-e154　2018/04/01
Publisher: Lippincott Williams and Wilkins
DOI： 10.1097/TP.0000000000002080 　

ISSN： 0041-1337
Impact of the Trough Level of Calcineurin Inhibitor on the Prevalence of Donor-Specific Human Leukocyte Antigen Antibodies During Long-Term Follow-Up After Pediatric Liver Transplantation: Antibody Strength and Complement-Binding Ability. International-journal Peer-reviewed

Tokodai K, Miyagi S, Nakanishi C, Hara Y, Nakanishi W, Goto M, Unno M, Kamei T

Transplantation direct　3　(8)　e196　2017/08

DOI： 10.1097/TXD.0000000000000713 　

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BACKGROUND: In pediatric patients, long-term immunosuppression after liver transplantation (LT) is typically minimal. However, posttransplant donor-specific HLA antibodies (DSAs) may be prevalent under these conditions. Here, we evaluated the effects of minimized calcineurin inhibitor (CNI) on DSA development to assess the validity of minimized/withdrawn immunosuppression. METHODS: We retrospectively examined 66 patients who underwent pediatric LT at our institution between July 1991 and October 2013. Patients were divided into 2 groups based on the CNI trough level. The cutoff trough levels were 3 and 30 ng/mL for tacrolimus and cyclosporine, respectively. Luminex single-antigen bead assays were performed, and the cutoff for a positive reaction was set at a mean fluorescence intensity (MFI) of at least 1000. RESULTS: The mean recipient ages at the time of LT were 29.1 and 77.2 months for the low and regular CNI groups, respectively (P = 0.0007). Univariate logistic regression analysis revealed that recipient age at LT younger than 3 years (P = 0.0099) and low CNI (P < 0.0001) were significantly associated with DSA development. In multivariate analysis, low CNI was an independent risk factor of DSA development (P = 0.0011). Of 15 high-MFI DSAs, 3 were anti-DR, and 12 were anti-DQ. Two of 3 anti-DR DSAs and 11 of 12 anti-DQ DSAs had complement-binding ability and high MFIs. CONCLUSIONS: CNI minimization was an independent risk factor for posttransplant DSA during long-term follow-up after pediatric LT. Adjusting CNI to appropriate levels is a safe first step to prevent the immunological effects of DSA.
Risk factors for recurrence in stage II/III colorectal cancer patients treated with curative surgery: The impact of postoperative tumor markers and an infiltrative growth pattern. International-journal Peer-reviewed

Kazuaki Tokodai, Hiroto Narimatsu, Akiko Nishida, Kai Takaya, Yasuyuki Hara, Naoki Kawagishi, Eiji Hashizume, Noriaki Ohuchi

Journal of surgical oncology　114　(3)　368-74　2016/09

DOI： 10.1002/jso.24320 　

ISSN： 0022-4790

eISSN： 1096-9098
The 5-time point oral glucose tolerance test as a predictor of new-onset diabetes after kidney transplantation Peer-reviewed

Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Tetsuro Takayama, Atsushi Nakamura

DIABETES RESEARCH AND CLINICAL PRACTICE　103　(2)　298-303　2014/02

DOI： 10.1016/j.diabres.2013.12.049 　

ISSN： 0168-8227

eISSN： 1872-8227
Attenuation of Cross-Talk Between the Complement and Coagulation Cascades by C5a Blockade Improves Early Outcomes After Intraportal Islet Transplantation Peer-reviewed

Kazuaki Tokodai, Masafumi Goto, Akiko Inagaki, Wataru Nakanishi, Norihiko Ogawa, Kazushige Satoh, Naoki Kawagishi, Satoshi Sekiguchi, Bo Nilsson, Noriko Okada, Hidechika Okada, Susumu Satomi

TRANSPLANTATION　90　(12)　1358-1365　2010/12

DOI： 10.1097/TP.0b013e3181ffb9f5 　

ISSN： 0041-1337
Impact of rituximab-based desensitization on T cell-mediated rejection in ABO-incompatible liver transplantation.

Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Muneyuki Matsumura, Yoshihiro Shono, Hiroyuki Ogasawara, Ryusuke Saito, Naruhito Takido, Michiaki Unno, Takashi Kamei

Surgery today　2026/01/05

DOI： 10.1007/s00595-025-03162-3 　

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PURPOSE: Rituximab-based desensitization has enabled successful ABO-incompatible (ABO-I) liver transplantation (LT) by preventing antibody-mediated rejection (AMR). However, its effect on T cell-mediated rejection (TCMR) remains unclear. We conducted a comparative analysis between ABO-compatible (ABO-C) and ABO-I LT to evaluate the effects of rituximab-based desensitization on TCMR. METHODS: We retrospectively analyzed 45 LT recipients (32 ABO-C and 13 ABO-I recipients) treated with basiliximab-based immunosuppression. The ABO-I group additionally received rituximab-based desensitization therapy. The lymphocyte subpopulations, rejection, adverse events, and outcomes were assessed. RESULTS: AMR was not observed in either group. TCMR occurred within 4 weeks post-transplantation in 0% of ABO-C cases and 38.5% of ABO-I cases (P = 0.0011). In ABO-C, a significant increase in B cells (CD19+) was observed within the first week, whereas in ABO-I, B cells remained depleted and an increase in T cells (CD3+) was observed. In all the ABO-I cases, TCMR occurred under suppressed CD25 + conditions. Adverse events were comparable between the groups. The 1-year survival rates for the ABO-C and ABO-I groups were 96.9% and 100%, respectively. CONCLUSION: Rituximab-based desensitization in ABO-I LT is associated with an increased incidence of early TCMR. Rituximab-induced B-cell depletion may promote T-cell activation through an IL-2-independent pathway, potentially contributing to increased TCMR.
Solitary Lymph Node Metastasis of Sigmoid Colon Cancer to Posterior Site of Inferior Vena Cava: A Case Report.

Yasunao Sai, Ryusuke Saito, Masaki Sato, Naruhito Takido, Kaoru Okada, Chihiro Inoue, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Shinobu Ohnuma, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　2025/11/20

DOI： 10.1620/tjem.2025.J136 　
Prone Position-Induced Visceral Organ Injury During Spinal Surgery for Idiopathic Scoliosis: A Case Report of Hepatic, Pancreatic, and Renal Complication.

Nozomu Okada, Ryusuke Saito, Keita Cha, Shouki Suzuki, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　2025/11/06

DOI： 10.1620/tjem.2025.J132 　
Liver Transplantation for Acute Liver Failure After Intentional Iron Overdose: A Case Report and Literature Review. International-journal

Kyohei Kasuda, Ryusuke Saito, Toku Nishiyama, Ryosuke Yachi, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Yuto Yamazaki, Kazuaki Tokodai, Michiaki Unno, Takashi Kamei

Pediatric transplantation　29　(7)　e70197　2025/11

DOI： 10.1111/petr.70197 　

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BACKGROUND: Acute iron poisoning can result in severe complications such as acute liver failure, renal dysfunction, and cerebral edema. Iron overdose, often accidental in infants or intentional in adolescents for suicidal attempts, can be fatal due to its cytotoxic effects. CASE PRESENTATION: We present the case of a 13-year-old female who developed acute liver failure due to iron overdose (45 mg/kg). She had been prescribed iron supplements for anemia but overdosed due to personal distress. Despite initial treatment with deferoxamine, her condition deteriorated. Imaging revealed extensive liver necrosis, and she developed fulminant hepatic failure with coma. Continuous renal replacement therapy for anuria and plasma exchange was initiated. Brain MRI demonstrated cerebral edema and central herniation when her level of consciousness decreased. Osmotherapy and fluid management helped stabilize her neurological status. After 18 days, the patient underwent deceased donor liver transplantation. After surgery, liver and renal function recovered completely, and she was discharged 40 days after surgery without neurological complications. From the review of the literature, early intervention after overdose could lead to a good prognosis. In addition, all reported cases of renal dysfunction from iron overdose resolved after liver transplantation. CONCLUSIONS: Effective management of complications such as cerebral edema and renal failure is critical to bridging the patient to transplantation. Liver transplantation remains the only definitive treatment for iron-induced liver failure, and timely intervention can significantly improve survival and recovery.
医師の働き方改革が始まって移植医療がburn-outしないための方策について東北大学における移植診療体制の最適化に向けた取り組み北欧移植施設の工夫をヒントに

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 齋藤竜助, 宇根範和, 岡田薫, 和田基, 海野倫明, 亀井尚

移植　60　190-190　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
PEKTの現況とアンメットニーズ当院における先行的腎移植の現状と課題

菖野佳浩, 戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 小笠原弘之, 齊藤竜助, 宇根範和, 岡田薫, 海野倫明, 亀井尚

移植　60　206-206　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植の治療限界への挑戦当院の脳死肝移植におけるnightmare caseから考える移植適応の限界について

藤尾淳, 戸子台和哲, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 宇根範和, 海野倫明, 亀井尚

移植　60　222-222　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
リツキシマブが肝移植後T細胞関連拒絶反応へ与える影響

佐々木健吾, 戸子台和哲, 藤尾淳, 松村宗幸, 菖野佳浩, 小笠原弘之, 齊藤竜助, 海野倫明, 亀井尚

移植　60　294-294　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
本邦初のcompositeグラフトを使用した脳死肝小腸同時移植の1例

小笠原弘之, 滝戸成人, 齊藤竜助, 菖野佳浩, 松村宗幸, 佐々木健吾, 藤尾淳, 戸子台和哲, 工藤博典, 海野倫明, 亀井尚, 和田基

移植　60　322-322　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
東北大学における膵臓移植手術手技血栓症を防ぐ周術期管理と門脈吻合の工夫

松村宗幸, 戸子台和哲, 藤尾淳, 佐々木健吾, 小笠原弘之, 菖野佳浩, 宇根範和, 岡田薫, 海野倫明, 亀井尚

移植　60　398-398　2025/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
胸部臓器摘出に伴う腹部チームの役割と留意点

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 和田基, 海野倫明, 亀井尚

日本胸部外科学会定期学術集会　78回　JP7-5　2025/10
Publisher: (一社)日本胸部外科学会
鉄剤の過剰内服による急性肝不全に対し脳死肝移植を施行し救命し得た一例

西山徳, 斉藤竜助, 戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 海野倫明, 亀井尚

日本消化器外科学会総会　80回　3593-3593　2025/07
Publisher: (一社)日本消化器外科学会
脳死肝移植で救命に成功した、鉄剤過剰内服により生じた急性肝不全の一例

渡邊健吾, 井上淳, 笹崎智也, 土井耕太郎, 大内啓志, 澤橋里子, 小貫眞純, 佐藤公亮, 鶴岡未央, 佐野晃俊, 二宮匡史, 粕田恭平, 佐々木健吾, 藤尾淳, 戸子台和哲, 正宗淳

日本消化器病学会東北支部例会プログラム・抄録集　219回　77-77　2025/07
Publisher: 日本消化器病学会-東北支部
Coagulation activation and hepatic engraftment of human amnion-derived cells after intraportal transplantation in rats. International-journal

Miyako Tanaka, Kazuaki Tokodai, Kaoru Okada, Masato Sato, Hitomi Okita, Takako Ito, Tetsuro Hoshiai, Masatoshi Saito, Toshio Miki, Michiaki Unno, Takashi Kamei, Masafumi Goto

Regenerative medicine　20　(6)　233-242　2025/06

DOI： 10.1080/17460751.2025.2526915 　

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AIMS: Human amniotic epithelial cells (hAECs) have emerged as a promising cell source for regenerative medicine, with intraportal transplantation as a potential delivery route. However, the extent to which hAECs induce an immediate inflammatory response remains unclear. This study investigated tissue factor (TF) expression in isolated hAECs and assessed coagulation activation following intraportal transplantation in a rat model. MATERIALS AND METHODS: TF expression was analyzed before and after cryopreservation, while thrombin - antithrombin (TAT) complex levels were measured to evaluate coagulation activation. To assess engraftment and hepatocyte-like function, hAECs were transplanted into non-albuminemic rats, followed by serial measurements of serum human albumin levels and histological liver analysis. RESULTS: The findings indicate that hAECs express TF pre- and post-cryopreservation. Intraportal transplantation resulted in a significant increase in plasma TAT levels, which was mitigated by heparin administration. Furthermore, human albumin levels increased post-transplantation, and albumin-positive cells were detected in the liver on day 21. CONCLUSION: These results suggest that intraportal hAEC transplantation is a feasible approach for hepatic engraftment; however, TF expression may trigger coagulation activation, potentially leading to an instant blood-mediated inflammatory reaction. Further research is warranted to optimize anticoagulation strategies and evaluate long-term engraftment efficacy for clinical applications.
外科領域におけるAYA世代の移行期医療の現状と課題小児肝移植後の長期経過症例における課題と対策

佐々木健吾, 戸子台和哲, 藤尾淳, 松村宗幸, 菖野佳浩, 小笠原弘之, 齊藤竜助, 滝戸成人, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　125回　SY-5　2025/04
Publisher: (一社)日本外科学会
他臓器合併切除を伴う後腹膜腫瘍切除の周術期成績と安全に切除するための工夫

小笠原弘之, 戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　125回　SF-4　2025/04
Publisher: (一社)日本外科学会
肝移植医療の現状と将来展望東北大学における肝移植と働き方改革両立の試み無理なく楽しく働ける肝移植チームを目指して

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 滝戸成人, 石川裕貴, 工藤博典, 和田基, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　125回　PD-2　2025/04
Publisher: (一社)日本外科学会
Effects of human amniotic membrane on the angiogenesis and healing of ischemic wounds in a rat model. International-journal

Masato Sato, Kazuaki Tokodai, Kaoru Okada, Hiroyuki Ogasawara, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Hirofumi Sugawara, Daijirou Akamatsu, Michiaki Unno, Masafumi Goto, Takashi Kamei

Journal of biomaterials applications　39　(7)　789-796　2025/02

DOI： 10.1177/08853282241289919 　

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Although the human amniotic membrane (hAM) has been demonstrated to promote angiogenesis, its efficacy in healing ischemic wounds remains unknown. Therefore, the current study aimed to evaluate the potential of hAM as a dressing for treating ischemic wounds. The inferior abdominal wall arteries and veins of male rats were divided, and an ischemic wound was created on each side of the abdominal wall. Of the two ischemic wounds created, only one was covered with hAM, and its wound healing effect was determined by measuring the wound area. Angiogenesis was assessed by measuring microvessel density (MVD). On day 5, the mean wound area changed from 400 mm2 to 335.4 (260-450) mm2 in the hAM group and to 459 (306-570) mm2 in the control group (p = 0.0051). MVD was 19.0 (10.4-24.6) in the hAM group and 15.1 (10.6-20.8) in the control group (p = 0.0026). No significant differences in local pro- and anti-inflammatory cytokine levels were observed between the two groups. Histological examination revealed no rejection of the transplanted hAM. Therefore, the hAM may serve as a novel wound dressing that can promote angiogenesis and healing in ischemic wounds.
The First Case of Liver-Intestine En-Bloc Transplantation in Japan.

Hiroyuki Ogasawara, Kyohei Kasuda, Naruhito Takido, Ryusuke Saito, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Hironori Kudo, Michiaki Unno, Takashi Kamei, Motoshi Wada

Surgical case reports　11　(1)　2025

DOI： 10.70352/scrj.cr.25-0340 　

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INTRODUCTION: Simultaneous liver-intestine transplantation is indicated for intestinal failure associated liver disease (IFALD), which can be caused by conditions such as intestinal motility disorders or short bowel syndrome. Currently, the most common grafts for liver-intestine transplantation are multivisceral transplantation (MVT) grafts consisting of the liver, stomach, duodenum, pancreas, small intestine, and colon, or liver-intestine grafts derived from the MVT graft but without the stomach. However, at the time of transplantation in the present case, Japanese regulations did not permit simultaneous pancreas transplantation in a non-diabetic recipient, which is generally required for this type of graft. Therefore, in the 2 previously reported domestic cases, the liver and intestine grafts were transplanted separately as non-composite grafts. Early in the development of MVT, liver-intestine grafts, excluding the stomach, duodenum, and pancreas, were used. We adopted this graft configuration for a 14-year-old female with megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) complicated by IFALD and performed, for the 1st time in Japan, a composite liver-intestine transplantation under existing regulations. CASE PRESENTATION: The patient was a 14-year-old female who was maintained on minimal enteral feeding via an intestinal stoma and parenteral nutrition because of MMIHS. Since approximately year X-7, her IFALD progressed, leading to portal hypertension with gastrointestinal bleeding and hypersplenism, which led to a significant decline in her quality of life. She was listed for deceased donor liver-intestine transplantation and a suitable donor became available in December X. The stomach, duodenum, and pancreas of the donor were resected in situ, and a descending aortic graft was interposed at the caudal side of the superior mesenteric artery; arterial anastomosis was performed on the recipient's infrarenal abdominal aorta. The hepatic vein was anastomosed using the piggyback technique. Although a small amount of parenteral nutrition was still required because of colitis, the patient was gradually progressing toward complete enteral nutrition. No evidence of rejection was observed, and the patient was discharged. CONCLUSIONS: We report successful composite liver-intestine transplantation using a graft that excluded the stomach, duodenum, and pancreas, which led to good clinical outcomes.
Bile Leakage after Liver Transplantation Owing to Stricture of Afferent Jejunal Loop Caused by an Intussusception Valve after Biliary Atresia Surgery: A Case Report.

Hironobu Ito, Ryusuke Saito, Masaki Sato, Kyohei Kasuda, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Ryuji Okubo, Kengo Sasaki, Atsushi Fujio, Hironori Kudo, Kazuaki Tokodai, Motoshi Wada, Michiaki Unno, Takashi Kamei

Surgical case reports　11　(1)　2025

DOI： 10.70352/scrj.cr.25-0209 　

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INTRODUCTION: Biliary atresia (BA) is a progressive cholangiopathy in neonates that results in biliary cirrhosis and liver failure without early intervention. Hepatic portoenterostomy (Kasai operation) remains the standard treatment, significantly improving survival rates. However, postoperative cholangitis is a major determinant of prognosis. To prevent cholangitis, various surgical modifications, including anti-reflux procedures such as intussusception anti-reflux valves (IAV), have been introduced. Although IAV has been widely adopted, some reports suggest that long-term survivors may develop afferent jejunal limb stenosis, leading to complications such as cholangitis and intestinal obstruction. Herein, we report a case of afferent jejunal loop stricture caused by IAV, which became symptomatic after liver transplantation (LT). CASE PRESENTATION: A 34-year-old man with a history of BA underwent Kasai operation with IAV and spur valve at 77 days of age. Despite experiencing recurrent cholangitis in adulthood, he survived with his native liver until developing liver cirrhosis and porto-pulmonary hypertension, necessitating deceased donor LT. Preoperative imaging revealed portal vein obstruction and dilated collateral circulation. During LT, severe adhesions and afferent limb dilation were observed, requiring a 30 cm resection of the jejunal limb. Postoperatively, he developed cholangitis, and imaging on postoperative day 16 revealed an anastomotic leak with an intra-abdominal abscess. Retrospectively, CT image before LT demonstrated the dilatation of the afferent limb and the stricture due to IAV was highly suspected. Double-balloon endoscopy confirmed complete afferent limb obstruction due to IAV-related stenosis. Surgical reconstruction with resection of the obstructed Roux-en-Y limb and creation of a new hepatojejunal anastomosis was performed. The patient recovered well and was discharged on postoperative day 45 without further complications. CONCLUSIONS: This case highlights the possibility for late-onset afferent jejunal stricture due to IAV in BA patients undergoing LT. The narrowing likely results from long-term fibrotic changes after 34 years from BA operation. Given the increasing number of BA survivors receiving LT, awareness of IAV-related complications is crucial. In cases with suspected afferent limb stenosis, preoperative assessment and consideration of jejunal limb resection during LT may help prevent postoperative complications.
A novel method of pancreatic islet transplantation at the liver surface using a gelatin hydrogel nonwoven fabric. International-journal

Yukiko Endo Kumata, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Ryusuke Saito, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

Cell transplantation　34　9636897251328419-9636897251328419　2025

DOI： 10.1177/09636897251328419 　

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Considering the limitations of intraportal transplantation (Tx), we sought to establish an alternative approach for it-transplanting islets onto the liver surface (LS) by optimizing adipose tissue-derived stem cell (ADSC) co-Tx procedures with a gelatin hydrogel nonwoven fabric (GHNF). In the in vivo study, we examined the use of the GHNF, the effectiveness of islet covering materials, and preferred procedures for ADSC co-Tx using a syngeneic rat model. Immunohistochemical staining was performed to evaluate the extracellular matrix (ECM) expression and angiogenesis. In the in vitro study, we analyzed the culture supernatants to identify crucial factors secreted from ADSCs in different ADSC co-Tx procedures. It was shown that the GHNF should be used to cover the islets but not to embed internally (encapsulate) them. Utilization of the GHNF in LS Tx resulted in significantly better glucose changes (P = 0.0002) and cure rate of diabetic recipients (P = 0.0003) than the use of a common adhesion barrier. Although neovascularization was comparable among groups, ECM reconstitution tended to be higher when the GHNF was used. ADSC co-Tx further enhanced ECM reconstitution only when ADSCs were cultured in the GHNF before islet Tx. Leptin, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and several chemokines were identified as candidate factors for enhancing ECM reconstitution (P < 0.001). The inhibition assay using antagonist suggested that leptin might be at least in part responsible for the difference in transplant efficiency in distinct ADSC co-Tx methods. This study showed that the GHNF effectively improved the outcomes of LS islet Tx, mainly due to ECM reconstitution around the islets. Furthermore, we established a novel method of LS islet Tx by combining a GHNF with ADSCs, which is equally effective as intraportal Tx.
Anterior Mediastinal Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma: A Case Report and Literature Review. International-journal

Tomoaki Tabata, Ryusuke Saito, Takeki Taniguchi, Kyohei Kasuda, Naruhito Takido, Hiroyuki Ogasawara, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Takanori Morikawa, Michiaki Unno, Takashi Kamei

Surgical case reports　11　(1)　2025

DOI： 10.70352/scrj.cr.24-0025 　

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INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignant tumor with a poor prognosis. Lymph node (LN) metastasis is found in 15% of ICC at the time of initial diagnosis. However, the LN metastasis to the anterior mediastinum is extremely rare. Herein, we report a case of anterior mediastinal LN metastasis of ICC. CASE PRESENTATION: The patient is a 74-year-old man who had surgery for cervical esophageal cancer. During follow-up, a low-density hepatic tumor and swollen LNs in the anterior mediastinum were detected. The tumor of the liver was diagnosed as ICC by needle biopsy. Excisional biopsy of the LN was performed and the diagnosis was metastasis of ICC. Because the prognosis of the patient with ICC Stage IVB is poor, the patient received 8 courses of chemotherapy. Although the new lesion appeared next to the main tumor, these tumors were located in the left liver. In addition, it was difficult for the patient to continue the chemotherapy due to the renal dysfunction. Hepatectomy with lymphadenectomy was performed. The patient survives without recurrence for 9 months after surgery. This is the first report of anterior mediastinal metastasis of ICC without any other organ involvement. CONCLUSIONS: Metastasis to the anterior mediastinum of hepatic tumor can be explained by the system that lymphatic fluid running under the capsule of the liver drains to the anterior mediastinal LNs through the coronary ligament. Metastasis of ICC to mediastinal LNs can occur when the tumor is located at the surface of the liver. Excisional biopsy is effective in determining the accurate disease stage and the treatment strategy.
The TEG 6s Global Hemostasis System is Useful for Coagulation Management in Simultaneous Pancreas and Kidney Transplantation: The First Two Cases. International-journal

Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Hiroyuki Ogasawara, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

Transplantation proceedings　56　(9)　2021-2026　2024/11

DOI： 10.1016/j.transproceed.2024.10.017 　

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INTRODUCTION: Hypercoagulability-related graft thrombosis is the leading cause of graft failure after simultaneous pancreas-kidney transplantation (SPK). Addressing this issue is crucial to improve the outcomes of SPK recipients. Thromboelastography (TEG) has been used to assess the coagulation profiles of SPK recipients. Recently, a new-generation TEG device, the TEG 6s Global Hemostasis System, was introduced. This device offers advantages over TEG 5000, including less frequent calibration requirements, ease of use, and reduced sensitivity to movement. We hypothesized that TEG 6s would enhance coagulation management in SPK. METHODS: We report two cases of Asian female SPK recipients in whom TEG 6s was used to assess coagulation status at six preset times during and after surgery. RESULTS: Preoperatively, both patients exhibited hypercoagulability on TEG 6s. Postoperative intravenous heparin was administered, and the dose was titrated based on the TEG 6s results. Vascular thrombosis was not observed in either patient. Detailed TEG 6s and standard laboratory test results are reported. This pilot study demonstrates that TEG 6s monitoring can effectively assess coagulation status in SPK recipients, aiding in optimal coagulation management and reducing the risk of thrombotic complications leading to graft loss. The TEG 6s facilitated real-time and accurate coagulation assessment, allowing for tailored anticoagulant therapy. CONCLUSIONS: This is the first observational study to use TEG 6s in SPK recipients, indicating its potential benefits in improving patient outcomes. Further studies with larger sample sizes are warranted to validate these findings and establish comprehensive guidelines for using TEG 6s in SPK procedures.
当科におけるロボット支援肝切除の導入と教育について

藤尾淳, 戸子台和哲, 佐々木健吾, 菖野佳浩, 小笠原弘之, 石川裕貴, 滝戸成人, 海野倫明, 亀井尚

日本臨床外科学会雑誌　85　(増刊)　S405-S405　2024/10
Publisher: 日本臨床外科学会
ISSN： 1345-2843

eISSN： 1882-5133
膵島移植においてアロ免疫拒絶制御以外に別の膵島生着促進作用も併せ持つ新規免疫抑制薬の開発

鈴木翔輝, 猪村武弘, 稲垣明子, 前川正充, 奥平貴成, 片野匠, 公文代將希, 佐藤裕, 戸子台和哲, 海野倫明, 亀井尚, 渡邉君子, 後藤昌史

Organ Biology　31　(3)　106-106　2024/10
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204
Practical Coagulation Management in Liver Transplantation through Point-of-Care Analysis using the TEG 6s Global Hemostasis System in Japan.

Muneyuki Matsumura, Kengo Sasaki, Kazuaki Tokodai, Koji Miyazawa, Atsushi Fujio, Hiroyuki Ogasawara, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　2024/09/05

DOI： 10.1620/tjem.2024.J087 　
移植医療における働き方改革-具体的対応も含めて- サステナブルな移植医療を遂行するための当科の取り組み

藤尾淳, 戸子台和哲, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 滝戸成人, 石川裕貴, 海野倫明, 亀井尚

移植　59　(総会臨時)　155-155　2024/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
移植医が取り組む臓器摘出手術における省力化腹部4臓器摘出を担う移植チームにおける省力化の試み Z世代にも受け入れられる職場環境を目指して

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 石川裕貴, 滝戸成人, 多田圭佑, 工藤博典, 和田基, 海野倫明, 亀井尚

移植　59　(総会臨時)　168-168　2024/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植における免疫抑制療法のベストプラクティスは? 当科における肝移植後免疫抑制導入療法におけるbasiliximabの使用経験

佐々木健吾, 戸子台和哲, 藤尾淳, 松村宗幸, 菖野佳浩, 小笠原弘之, 石川裕貴, 滝戸成人, 海野倫明, 亀井尚

移植　59　(総会臨時)　208-208　2024/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
高難度膵臓移植症例に対するアプローチ:こんな症例どうする? 当施設における外科合併症の経験改善点および現在の方針

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 石川裕貴, 滝戸成人, 海野倫明, 亀井尚

移植　59　(総会臨時)　218-218　2024/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵腎同時移植におけるThromboelastogramを用いた至適凝固管理

松村宗幸, 戸子台和哲, 藤尾淳, 佐々木健吾, 小笠原弘之, 菖野佳浩, 石川祐貴, 滝戸成人, 海野倫明, 亀井尚

移植　59　(総会臨時)　342-342　2024/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝胆膵疾患診療:予後改善にむけた早期診断と治療脳死肝移植増加に伴う急性肝不全早期診断の意義

戸子台和哲, 藤尾淳, 佐々木健吾, 松村宗幸, 菖野佳浩, 小笠原弘之, 石川裕貴, 滝戸成人, 海野倫明, 亀井尚

日本消化器病学会東北支部例会プログラム・抄録集　217回　61-61　2024/07
Publisher: 日本消化器病学会-東北支部
膵臓移植・膵島移植・人工膵臓の現状と展望皮下膵島移植における低酸素環境改善が移植膵島グラフトに与える影響

三頭啓明, 猪村武弘, 稲垣明子, 鈴木翔輝, 遠藤有希子, 片野匠, 戸子台和哲, 渡邉君子, 亀井尚, 海野倫明, 後藤昌史

膵臓　39　(3)　A279-A279　2024/07
Publisher: (一社)日本膵臓学会
ISSN： 0913-0071

eISSN： 1881-2805
Sustainableな肝胆膵・移植外科の未来を考える Z世代を肝移植に引き込むために大講座の肝胆膵外科の医局長が考えていること

藤尾淳, 戸子台和哲, 宮澤恒持, 佐々木健吾, 松村宗幸, 三頭啓明, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　124回　WS-1　2024/04
Publisher: (一社)日本外科学会
孤立性前縦隔リンパ節転移を来した肝内胆管癌の1例

谷口毅樹, 齊藤竜助, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 三頭啓明, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　124回　RS-3　2024/04
Publisher: (一社)日本外科学会
マージナルドナーからの臓器提供を生かした脳死肝移植ドナー数増加の試み

佐藤怜, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 三頭啓明, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　124回　RS-2　2024/04
Publisher: (一社)日本外科学会
膵腎同時移植後にGVHDを発症したHLA型一方向性0ミスマッチの一症例

小林紗也, 松村宗幸, 関修, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 三頭啓明, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　124回　RS-4　2024/04
Publisher: (一社)日本外科学会
Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity. International-journal

Yuki Ishikawa, Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Kazuaki Tokodai, Fumiyoshi Fujishima, Shin Kawanabe, Takuyuki Katabami, Akira Ikeya, Miho Yamashita, Yutaka Oki, Hiroshi Nanjo, Fumitoshi Satoh, Akihiro Ito, Michiaki Unno, Takashi Kamei, Hironobu Sasano, Takashi Suzuki

The Journal of steroid biochemistry and molecular biology　238　106462-106462　2024/01/15

DOI： 10.1016/j.jsbmb.2024.106462 　

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Adrenocortical carcinoma (ACC) patients with glucocorticoid excess have been reported to be associated with decreased tumor-infiltrating immune cells, but the effects of in situ glucocorticoid production on tumor immunity have remained unknown. In addition, ACC was also known to harbor marked intra-tumoral heterogeneity of steroidogenesis or disorganized steroidogenesis. Therefore, in this study, we immune-profiled tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) and pivotal steroidogenic enzymes of glucocorticoid biosynthesis (CYP17A and CYP11B1) to explore the potential effects of in situ glucocorticoid production and intra-tumoral heterogeneity/disorganized steroidogenesis on tumor immunity of ACC. We also studied the correlations of the status of tumor immunity with that of angiogenesis and tumor grade to further explore the tumor tissue microenvironment of ACC. TILs (CD3, CD4, CD8, and FOXP3), TAMs (CD68 and CD163), key steroidogenic enzymes of glucocorticoid (CYP17A and CYP11B1), angiogenesis (CD31 and vasohibin-1 (VASH-1)), tumor grade (Ki-67 and Weiss score) were immunohistochemically evaluated in 34 ACCs. Increased CYP17A immunoreactivity in the whole tumor area was significantly positively correlated with FOXP3-positive TILs (p = 0.021) and negatively with CD4/CD3 ratio (p = 0.001). Increased CYP11B1 immunoreactivity in the whole tumor area was significantly positively correlated with CD8/CD3 (p = 0.039) and CD163/CD68 ratios (p = 0.006) and negatively with CD4-positive TILs (p = 0.036) and CD4/CD3 ratio (p = 0.001). There were also significant positive correlations between CYP17A and CD8 (r = 0.334, p < 0.001) and FOXP3-positive TILs (r = 0.414, p < 0.001), CD8/CD3 ratio (r = 0.421, p < 0.001), and CD68-positive TAMs (r = 0.298, p < 0.001) in randomly selected areas. Significant positive correlations were also detected between CYP11B1 and CD8/CD3 ratio (r = 0.276, p = 0.001) and negative ones detected between CYP11B1 and CD3- (r = -0.259, p = 0.002) and CD4-positive TILs (r = -0.312, p < 0.001) in those areas above. Increased micro-vessel density (MVD) -VASH-1 was significantly positively correlated with CD68- (p = 0.015) and CD163-positive TAMs (p = 0.009) and CD163/CD68 ratio and the high VASH-1 with CD163-positive TAMs (p = 0.042). Ki-67 labeling index was significantly positively correlated with MAD-VASH-1 (p = 0.006) and VASH-1 (p = 0.006) status. Results of our present study indicated that in situ glucocorticoid production did influence the status of tumor immunity in ACC. In particular, increased levels of CYP17A and CYP11B1, both involved in glucocorticoid producing immunoreactivity played different effects on tumor immunity, i.e., reflecting the involvement of intra-tumoral heterogeneity and disorganized steroidogenesis of ACC, which also did indicate the importance of in situ approaches when analyzing tumor immunity of ACC.
A Gelatin Hydrogel Nonwoven Fabric Combined With Adipose Tissue-Derived Stem Cells Enhances Subcutaneous Islet Engraftment. International-journal

Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo Kumata, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

Cell transplantation　33　9636897241251621-9636897241251621　2024

DOI： 10.1177/09636897241251621 　

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Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet engraftment. We herein investigated whether the addition of adipose tissue-derived stem cells (ADSCs) to GHNF affected the outcome. A silicone spacer sandwiched between two GHNFs with (AG group) or without (GHNF group) ADSCs, or a silicone spacer alone (Silicone group) was implanted into the subcutaneous space of healthy mice at 6 weeks before transplantation, then diabetes was induced 7 days before transplantation. Syngeneic islets were transplanted into the pretreated space. Intraportal transplantation (IPO group) was also performed to compare the transplant efficiency. Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, and inflammatory mediators were evaluated. The results in the subcutaneous transplantation were compared using the Silicone group as a control. The results of the IPO group were also compared with those of the AG group. The AG group showed significantly better blood glucose changes than the Silicone and the IPO groups. The cure rate of AG group (72.7%) was the highest among the groups (GHNF; 40.0%, IPO; 40.0%, Silicone; 0%). The number of vWF-positive vessels in the subcutaneous space of the AG group was significantly higher than that in other groups before transplantation (P < 0.01). Lectin angiography also showed that the same results (P < 0.05). According to the results of the ADSCs tracing, ADSCs did not exist at the transplant site (6 weeks after implantation). The positive rates for laminin and collagen III constructed around the transplanted islets did not differ among groups. Inflammatory mediators were higher in the Silicone group, followed by the AG and GHNF groups. Pretreatment using bioabsorbable scaffolds combined with ADSCs enhanced neovascularization in subcutaneous space, and subcutaneous islet transplantation using GHNF with ADSCs was superior to intraportal islet transplantation.
A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats. International-journal

Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo Kumata, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

Cells　13　(1)　2023/12/26

DOI： 10.3390/cells13010051 　

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Although subcutaneous islet transplantation has many advantages, the subcutaneous space is poor in vessels and transplant efficiency is still low in animal models, except in mice. Subcutaneous islet transplantation using a two-step approach has been proposed, in which a favorable cavity is first prepared using various materials, followed by islet transplantation into the preformed cavity. We previously reported the efficacy of pretreatment using gelatin hydrogel nonwoven fabric (GHNF), and the length of the pretreatment period influenced the results in a mouse model. We investigated whether the preimplantation of GHNF could improve the subcutaneous islet transplantation outcomes in a rat model. GHNF sheets sandwiching a silicone spacer (GHNF group) and silicone spacers without GHNF sheets (control group) were implanted into the subcutaneous space of recipients three weeks before islet transplantation, and diabetes was induced seven days before islet transplantation. Syngeneic islets were transplanted into the space where the silicone spacer was removed. Blood glucose levels, glucose tolerance, immunohistochemistry, and neovascularization were evaluated. The GHNF group showed significantly better blood glucose changes than the control group (p < 0.01). The cure rate was significantly higher in the GHNF group (p < 0.05). The number of vWF-positive vessels was significantly higher in the GHNF group (p < 0.01), and lectin angiography showed the same tendency (p < 0.05). The expression of laminin and collagen III around the transplanted islets was also higher in the GHNF group (p < 0.01). GHNF pretreatment was effective in a rat model, and the main mechanisms might be neovascularization and compensation of the extracellular matrices.
Small Intestinal Adenocarcinoma Arising at the Anastomotic Site after Kasai Operation for Biliary Atresia: A Case Report and Literature Review.

Yuki Ishikawa, Ryusuke Saito, Keigo Murakami, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Kazuki Degawa, Yoshinobu Kobayashi, Ryo Muto, Kazuaki Tokodai, Toru Furukawa, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　261　(4)　267-272　2023/12/16

DOI： 10.1620/tjem.2023.J080 　

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Biliary atresia is an obliterative cholangiopathy of unknown etiology. Hepatic portoenterostomy, in which obliterated extrahepatic bile ducts are resected and bile flow is restored, known as Kasai operation, is performed within 3 months after birth. While this operation enhances long-term survival of patients, the occurrence of primary malignant hepatic tumors has been increasing. We report a case of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation. A 49-year-old man, who underwent Kasai operation for biliary atresia when he was 2 months old, experienced rapidly progressive jaundice and liver dysfunction. Deceased-donor liver transplantation was performed for liver failure. Macroscopically, there was a white-yellow tumor located at the anastomotic site of hepatic portoenterostomy of the resected liver. Pathological examination revealed a well-differentiated adenocarcinoma with some Paneth cells in the neoplastic lesion. Immunohistochemically, the tumor cells were negative for cytokeratin 7 (CK7) but positive for cytokeratin 20 (CK20) and a homeobox domain-containing transcription factor (CDX2). Mucin expression in tumor cells was negative for mucin 1 (MUC1) and mucin 6 (MUC6) and positive for mucin 2 (MUC2) and mucin 5AC (MUC5AC). The pathological diagnosis was small intestinal adenocarcinoma originating from the jejunum. The patient was discharged 48 days after the operation. The patient had not experienced recurrence at 10 months after the operation. This is the first report of small intestinal adenocarcinoma arising at the anastomotic site after Kasai operation for biliary atresia. Special care should be taken for the patients after Kasai operation with acute progressive jaundice and liver dysfunction because there is a possibility of malignancy in their native liver.
【血管外科疾患の治療と手術手技-消化器・一般外科医が知りたい他科の技と工夫】他科との連携手術腫瘍・血管合併切除時の要点

鈴木峻也, 赤松大二朗, 戸子台和哲, 芹澤玄, 梅津道久, 亀井尚

手術　77　(13)　1923-1932　2023/12
Publisher: 金原出版(株)
ISSN： 0037-4423
Living-Donor Liver Transplantation for Erythropoietic Protoporphyria: A Case Report and Literature Review.

Hiroyuki Ogasawara, Kazuaki Tokodai, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Yoshihiro Shono, Mineto Ohta, Yuki Ishikawa, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　261　(2)　117-122　2023/10/07

DOI： 10.1620/tjem.2023.J061 　

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Erythropoietic protoporphyria (EPP) is a very rare disease with an estimated prevalence of 1 in 200,000 individuals. Decreased ferrochelatase activity causes the accumulation of protoporphyrin in the body, and light exposure results in the generation of active oxygen, causing photosensitivity. Liver damage has the greatest influence on the prognosis, and liver transplantation is the only treatment option for patients with decompensated liver cirrhosis. We report a case of living-donor liver transplantation for decompensated liver cirrhosis associated with EPP. The patient was a 52-year-old male who led a normal life except for mild photosensitivity. When the patient was 37-year-old, hepatic dysfunction was noticed. At 48-year-old, high erythrocyte protoporphyrin levels, skin biopsy, and genetic tests resulted in a diagnosis of EPP. The patient underwent living- donor liver transplantation because of decompensated liver cirrhosis. In the operating room and intensive care unit, a special light-shielding film was applied to all light sources to block light with harmful wavelengths during treatment. Due to the need for special measures, a lecture on patients with EPP was given before surgery to deepen understanding among all medical professionals involved in the treatment. As a result, no adverse events occurred during the perioperative period, and the patient was discharged on the 46th post-operative day. Currently, the transplanted liver is functioning extremely well, and the patient is alive 3 years post-transplant. Herein, we describe a case of living donor liver transplantation for EPP with a brief literature review.
Tumor-to-Tumor Metastasis of Medullary Thyroid Carcinoma to Paraganglioma in a Multiple Endocrine Neoplasia Type 2B Patient: A Case Report and Literature Review.

Naruhito Takido, Ryusuke Saito, Kaoru Okada, Norifumi Kanai, Yoshihiro Shono, Hiroaki Mitsugashira, Muneyuki Matsumura, Kengo Sasaki, Koji Miyazawa, Atsushi Fujio, Kazuaki Tokodai, Keigo Murakami, Hironobu Sasano, Michiaki Unno, Takanori Ishida, Takashi Kamei

The Tohoku journal of experimental medicine　261　(1)　75-81　2023/09/20

DOI： 10.1620/tjem.2023.J058 　

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Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize to other tumors. Herein, we report an extremely rare case of tumor-to-tumor metastasis of medullary thyroid carcinoma to a paraganglioma in a patient with multiple endocrine neoplasia type 2B. Based on genetic examination, a 36-year-old woman was diagnosed with multiple endocrine neoplasia type 2B when she was 24 years old. She had a history of total thyroidectomy for medullary thyroid carcinoma and bilateral adrenalectomy for pheochromocytomas, which were performed when she was 15 years and 29 years old, respectively. Follow-up computed tomography demonstrated a retroperitoneal tumor of 30 mm in diameter beside the left kidney and a liver tumor of 16 mm in diameter located in segment 6. The retroperitoneal and liver tumors were surgically resected and examined by a pathologist. Histological examination revealed the classic Zellballen pattern in the retroperitoneal tumor, rendering the diagnosis of a paraganglioma recurrence. Inside the tumor, a white nodule positive for carcinoembryonic antigen, weakly positive for calcitonin, and negative for tyrosine hydroxylase, was identified and diagnosed as a metastatic medullary thyroid carcinoma with high malignant potential. The liver lesion was diagnosed as a metastasis of the medullary thyroid carcinoma. This is the first report of tumor-to-tumor metastasis of medullary thyroid carcinoma to paraganglioma in a patient with multiple endocrine neoplasia type 2B twenty years after total thyroidectomy.
不織布構造ゼラチン基材を用いた肝表面膵島移植法の検討

遠藤有希子, 稲垣明子, 猪村武弘, 鈴木翔輝, 片野匠, 戸子台和哲, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

移植　58　(総会臨時)　292-292　2023/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
10年以上の小児肝移植長期成績の課題当院における小児肝移植の長期成績の課題

佐々木健吾, 戸子台和哲, 藤尾淳, 宮澤恒持, 松村宗幸, 三頭啓明, 齊藤竜介, 亀井尚, 海野倫明

移植　58　(総会臨時)　173-173　2023/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵臓移植"HOW I DO IT" 東北大学における膵臓移植手術手技わたしのこだわり

松村宗幸, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 三頭啓明, 齋藤竜助, 海野倫明, 亀井尚

移植　58　(総会臨時)　200-200　2023/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植後の消化器癌スクリーニングの検討

藤尾淳, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 山名浩樹, 三頭啓明, 海野倫明, 亀井尚

日本消化器外科学会総会　78回　RS1-2　2023/07
Publisher: (一社)日本消化器外科学会
東北大学Cadaverトレーニングの現状と脳死ドナー臓器摘出手術における成果

戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 大和田祐二, 海野倫明, 亀井尚

日本消化器外科学会総会　78回　RS5-2　2023/07
Publisher: (一社)日本消化器外科学会
生体肝移植後胆管狭窄に対する治療アプローチ

佐々木健吾, 戸子台和哲, 藤尾淳, 柏館俊明, 宮澤恒持, 松村宗幸, 山名浩樹, 三頭啓明, 亀井尚, 海野倫明

日本消化器外科学会総会　78回　RS15-2　2023/07
Publisher: (一社)日本消化器外科学会
当科における腹腔鏡下再肝切除の適応と工夫について

岡田薫, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 森川孝則, 戸子台和哲, 海野倫明, 亀井尚

日本消化器外科学会総会　78回　P115-5　2023/07
Publisher: (一社)日本消化器外科学会
大腸癌肝転移症例における腹腔鏡下肝切除の長期および短期成績の検討

山名浩樹, 藤尾淳, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 三頭啓明, 亀井尚, 海野倫明

日本消化器外科学会総会　78回　P203-2　2023/07
Publisher: (一社)日本消化器外科学会
肝移植レシピエントにおけるサルコペニアの影響

三頭啓明, 藤尾淳, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 山名浩樹, 海野倫明, 亀井尚

日本消化器外科学会総会　78回　P270-4　2023/07
Publisher: (一社)日本消化器外科学会
Clinical Significance of the Mac-2 Binding Protein Glycosylated Isomer as a Surrogate Marker of Graft Fibrosis After Pediatric Liver Transplantation. International-journal

Hiroki Yamana, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroaki Mitsugashira, Michiaki Unno, Takashi Kamei

Transplantation proceedings　2023/04/30

DOI： 10.1016/j.transproceed.2023.03.053 　

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BACKGROUND: After pediatric liver transplantation, liver fibrosis may occur during long-term follow-up. Noninvasive markers for assessing this liver fibrosis are desired. Mac-2 binding protein glycosylated isomer (M2BPGi) has recently been reported as a useful biomarker for liver fibrosis. However, its usefulness in the pediatric population is yet to be established. This study investigated the clinical significance of M2BPGi levels as a surrogate marker of graft fibrosis after pediatric liver transplantation. METHODS: We retrospectively identified 96 patients who underwent pediatric liver transplantation at our institution between 1991 and 2015. The association between M2BPGi levels and other fibrosis markers was analyzed in 60 patients in whom fibrosis markers were measured. The association between fibrosis marker levels and graft fibrosis was assessed in 42 patients who underwent biopsies between 2016 and 2022. RESULTS: The M2BPGi levels were statistically correlated with the hyaluronic acid and type-IV collagen levels. None of the fibrosis markers were significantly associated with liver graft fibrosis, although the levels of these markers were slightly higher in patients with severe liver fibrosis than in those with mild fibrosis. CONCLUSIONS: The M2BPGi levels had a limited ability to assess liver graft fibrosis after pediatric liver transplantation, similar to other fibrosis markers. Further studies with larger cohorts are required to validate these findings externally.
先天性代謝異常症に対するヒト羊膜上皮細胞による新規細胞移植療法の確立

田中美也子, 戸子台和哲, 岡田薫, 齋藤昌利, 星合哲郎, 三木敏生, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　123回　DP-2　2023/04
Publisher: (一社)日本外科学会
再生医療が外科にもたらす変化再生医療の外科診療への応用と本学で進める「羊膜プロジェクト」の現状と課題

戸子台和哲, 岡田薫, 田中美也子, 渡辺祐記, 宇田川輝久, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 谷山裕亮, 赤松大二朗, 星合哲郎, 齋藤昌利, 三木敏生, 和田基, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　123回　SY-6　2023/04
Publisher: (一社)日本外科学会
腹腔鏡下肝切除におけるsurgical marginについての検討

宮澤恒持, 戸子台和哲, 藤尾淳, 柏舘俊明, 佐々木健吾, 松村宗幸, 山名浩樹, 三頭啓明, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　123回　DP-5　2023/04
Publisher: (一社)日本外科学会
肝部下大静脈欠損と内臓逆位を合併した胆道閉鎖症に対して脳死分割肝グラフトを用いた再肝移植の一例

山名浩樹, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 宮崎勇希, 三頭啓明, 戸子台和哲, 大沼忍, 亀井尚, 海野倫明

日本消化器病学会東北支部例会プログラム・抄録集　214回　91-91　2023/02
Publisher: 日本消化器病学会-東北支部
緊急手術を施行した左室補助循環装置装着中の急性胆嚢炎の1例

三頭啓明, 宮澤恒持, 戸子台和哲, 藤尾淳, 柏舘俊明, 佐々木健吾, 松村宗幸, 山名浩樹, 海野倫明, 亀井尚

日本腹部救急医学会雑誌　43　(2)　451-451　2023/02
Publisher: (一社)日本腹部救急医学会
ISSN： 1340-2242

eISSN： 1882-4781
周術期の栄養と運動は短期・長期成績をどう変えるか術前の栄養不良・骨格筋量が肝移植レシピエントに与える影響

三頭啓明, 藤尾淳, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 山名浩樹, 海野倫明, 亀井尚

外科と代謝・栄養　57　(3)　116-116　2023
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
Ideal Duration of Pretreatment Using a Gelatin Hydrogel Nonwoven Fabric Prior to Subcutaneous Islet Transplantation. International-journal

Ryusuke Saito, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Norifumi Kanai, Hiroaki Mitsugashira, Yukiko Endo, Takumi Katano, Shoki Suzuki, Kazuaki Tokodai, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Yasuhiko Tabata, Masafumi Goto

Cell transplantation　32　9636897231186063-9636897231186063　2023

DOI： 10.1177/09636897231186063 　

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Subcutaneous islet transplantation is a promising treatment for severe diabetes; however, poor engraftment hinders its prevalence. We previously revealed that a gelatin hydrogel nonwoven fabric (GHNF) markedly improved subcutaneous islet engraftment in comparison with intraportal islet transplantation. We herein investigated whether the duration of pretreatment using GHNF affected the outcome of subcutaneous islet transplantation. A silicone spacer with GHNF was implanted into the subcutaneous space of healthy mice at 2, 4, 6, or 8 weeks before transplantation, and then diabetes was induced 7 days before transplantation. Syngeneic islets were transplanted into the pretreated space. Blood glucose, intraperitoneal glucose tolerance, immunohistochemistry, inflammatory mediators, and gene expression were evaluated. The 6-week group showed significantly better blood glucose changes than the other groups (P < 0.05). The cure rate of the 6-week group (60.0%) was the highest among the groups (2-week = 0%, 4-week = 50.0%, 8-week = 15.4%). The number of von Willebrand factor (vWF)-positive vessels in the 6-week group was significantly higher than in the other groups at pre-islet and post-islet transplantation (P < 0.01 [vs 2-and 4-week groups] and P < 0.05 [vs all other groups], respectively). Notably, this beneficial effect was also observed when GHNF was implanted into diabetic mice injected with streptozotocin 7 days before GHNF implantation. The positive rates for laminin, collagen III, and collagen IV increased as the duration of pretreatment became longer and were significantly higher in the 8-week group (P < 0.01). Inflammatory mediators, including interleukin (IL)-1b, granulocyte colony-stimulating factor (G-CSF), and interferon (IFN)-γ, were gradually downregulated according to the duration of GHNF pretreatment and re-elevated in the 8-week group. Taken together, the duration of GHNF pretreatment apparently had an impact on the outcomes of subcutaneous islet transplantation, and 6 weeks appeared to be the ideal duration. Islet graft revascularization, extracellular matrix compensation of the islet capsule, and the inflammatory status at the subcutaneous space would be crucial factors for successful subcutaneous islet transplantation.
Postreperfusion Syndrome Presenting as Posttransplant Portal Hypertension due to Prolonged Elevation of Pulmonary Vascular Resistance and the Role of Nitroglycerin in Diagnosis and Treatment: A Case Report of Budd-Chiari Syndrome.

Takahiro Kawaji, Hiroaki Toyama, Norifumi Yoshida, Shoichiro Moteki, Ayaka Sasaki, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Shigehito Miyagi, Masanori Yamauchi

The Tohoku journal of experimental medicine　2022/12/08

DOI： 10.1620/tjem.2022.J105 　
GoTo 100yr企画老化のメカニズム人生100年時代における臓器移植診療の課題と展望

戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 和田基, 海野倫明, 後藤昌史, 亀井尚

Organ Biology　29　(3)　63-63　2022/11
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204
Probable posttransplant lymphoproliferative disorder after pediatric living donor liver transplantation: Is a biopsy still needed? International-journal

Muneyuki Matsumura, Shigehito Miyagi, Kazuaki Tokodai, Toshiaki Kashiwadate, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Yoshikatsu Saito, Norifumi Kanai, Michiaki Unno, Takashi Kamei

Clinical case reports　10　(11)　e6454　2022/11

DOI： 10.1002/ccr3.6454 　

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Posttransplant lymphoproliferative disorder (PTLD) is a complication of solid organ transplantation and is associated with Epstein-Barr virus (EBV). Recently, EBV-related PTLD was defined as probable PTLD or proven PTLD. Probable PTLD involves significant lymphadenopathy, hepatosplenomegaly, or other end-organ manifestations, without a histological diagnosis, together with significant EBV DNAemia. Proven PTLD is the detection of EBV-encoded proteins in a tissue specimen, together with symptoms and/or signs originating from the affected organ. Probable PTLD after pediatric liver transplantation has not been well documented. Therefore, here, we aimed to describe cases of five pediatric patients with probable PTLD after liver transplantation, who were successfully treated with preemptive immunosuppression reduction with or without rituximab. All five patients (age range, 1-4 years; two girls and three boys) had EBV DNAemia. Three patients developed probable PTLD within 12 months of transplantation. Further, three patients had a significantly high EBV viral load, but the other two patients with lymphadenopathy and end-organ manifestation had a relatively low EBV viral load. Early onset pediatric PTLD with significant EBV DNAemia is almost universally EBV-related. Biopsy was not performed in any patient due to the relative inaccessibility of the lesion and young age of the patients. If the patient's symptoms are too mild, if excisional biopsy is too difficult to perform, or if the patient is too sick to undergo an invasive procedure, initiating preemptive treatment without a histological diagnosis could be the treatment option.
ラット皮下膵島移植における不織布構造ゼラチン基材の前留置が移植結果へ及ぼす影響

齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 戸子台和哲, 亀井尚, 海野倫明, 田畑泰彦, 後藤昌史

Organ Biology　29　(3)　125-125　2022/11
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204
羊膜由来幹細胞と膵島の門脈内共移植による移植後膵島生着促進の試み

岡田薫, 戸子台和哲, 星合哲郎, 齋藤昌利, 海野倫明, 三木敏生, 後藤昌史, 亀井尚

移植　57　(総会臨時)　347-347　2022/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵・膵島移植の適応についての再考膵・膵島移植新時代における適応判定・ドナー選択の東北大新基準

戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 宮崎勇希, 山名浩樹, 宮城重人, 和田基, 海野倫明, 亀井尚, 後藤昌史

移植　57　(総会臨時)　206-206　2022/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵臓移植手術手技-私たちの工夫- 東北大学における膵臓移植手術手技課題とこれからの展望

松村宗幸, 戸子台和哲, 柏舘俊明, 藤尾淳, 宮澤恒持, 佐々木健吾, 宮城重人, 海野倫明, 亀井尚

移植　57　(総会臨時)　208-208　2022/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
胆道閉鎖症生体肝移植術後4年にレシピエント組織由来の胆管癌腹膜播種を生じた一例

佐々木健吾, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 宮崎勇希, 松村宗幸, 石川裕貴, 藤島史喜, 吉野裕顕, 東海林琢男, 海野倫明, 亀井尚

移植　57　(総会臨時)　390-390　2022/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
男女を問わず外科医が輝き続けるために持続可能社会における外科医の働き方男女ともに輝き続けるために必要なこと

柏舘俊明, 宮城重人, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 金井哲史, 西牧宏泰, 亀井尚, 海野倫明

日本外科学会雑誌　123　(5)　489-491　2022/09
Publisher: (一社)日本外科学会
ISSN： 0301-4894
A New Strategy of Liver Transplantation for Locally Advanced Unresectable Perihilar Cholangiocarcinoma Using Living Grafts With Simultaneous Resection of Recipients' Hepatic Artery and Portal Vein Without Neoadjuvant Radiation: A Case Report. International-journal

Shigehito Miyagi, Atsushi Fujio, Kei Nakagawa, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Hiroyasu Nishimaki, Taizo Hibi, Takashi Kamei, Michiaki Unno

Transplantation proceedings　2022/07/06

DOI： 10.1016/j.transproceed.2022.03.054 　

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BACKGROUND: Perihilar cholangiocarcinoma (pCCA) is often unresectable, because it includes crucial blood vessels in portal area. The prognosis of locally advanced unresectable cholangiocarcinomas is extremely poor. Recently, there have been several reports of the prognosis improving drastically with transplantation and combined chemoradiation therapy. However, liver transplantation for pCCA has 2 big problems. The first is that pCCA is located at a lethal position and its progress is sometimes rapid; therefore, the optimal timing of transplantation is sometimes lost. The second is vascular complications associated with neoadjuvant radiation, especially in living donor liver transplantation (LDLT). To overcome these problems, we performed conversion surgery using LDLT with simultaneous resection of the hepatic artery and portal vein, instead of neoadjuvant radiation. Herein, we report our experience of interposition reconstruction. METHODS: A 31-year-old man with primary sclerosing cholangitis (PSC) was diagnosed with locally advanced unresectable pCCA. The patient underwent radical chemotherapy (gemcitabine/cisplatin/S-1) and avoided radiation because of PSC. After 6 months, positron emission tomography-computed tomography revealed no lymph node metastasis. There was no time to wait. We immediately performed LDLT with simultaneous resection of hepatic artery and portal vein, and microsurgical reconstruction using auto-vessel grafts. RESULTS: The recipient recovered and was discharged 31 days posttransplant. His liver function improved, and he has had no recurrence after LDLT. CONCLUSION: LDLT with neoadjuvant radiation is associated with high risk of vascular complications. In some cases, conversion surgery after radical chemotherapy using good timing LDLT without radiation may increase chances of transplantation for locally advanced pCCA.
ヒト羊膜由来細胞を用いた細胞移植治療法確立に向けて

戸子台和哲, 田中美也子, 岡田薫, 星合哲郎, 齋藤昌利, 海野倫明, 三木敏生, 亀井尚, 後藤昌史

Organ Biology　29　(2)　124-127　2022/07
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204

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胎盤由来の生体材料は古くから実臨床に使用され、羊膜移植はすでに眼科領域で実施されている。羊膜由来細胞は安価かつ大量に採取が可能であるため、ドナー不足のため普及が進まない肝細胞移植を代替できる細胞ソースであると考えられる。羊膜由来細胞を用いた再生医療の応用、先天性代謝異常症への臨床応用に向けた課題、門脈内細胞移植後に引き起こされる即時型炎症反応と免疫応答について概説した。
【総論】各臓器サブサブスペシャルティ外科医の育成法東北大学における移植外科医育成プログラムの構築肝膵腎小腸摘出チームにおける取り組み

宮澤恒持, 宮城重人, 戸子台和哲, 藤尾淳, 柏舘俊明, 佐々木健吾, 松村宗幸, 齋藤純健, 亀井尚, 海野倫明

日本消化器外科学会総会　77回　WS15-8　2022/07
Publisher: (一社)日本消化器外科学会
血管合併症を有する高難度肝移植における手術手技の工夫浅大腿静脈グラフトを用いた血行再建法について

戸子台和哲, 宮崎勇希, 松村宗幸, 佐々木健吾, 宮澤恒持, 柏舘俊明, 藤尾淳, 宮城重人, 海野倫明, 亀井尚

日本消化器外科学会総会　77回　P013-3　2022/07
Publisher: (一社)日本消化器外科学会
脳死肺移植後の末期腎不全に対し、移植後11年で生体腎移植を施行したリンパ脈管筋腫症の1例

齋藤純健, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 太田嶺人, 宇根範和, 金井哲史, 渡辺有為, 秋葉美紀, 宮城重人, 岡田克典, 海野倫明, 亀井尚

日本臨床腎移植学会雑誌　10　(1)　91-95　2022/07
Publisher: (一社)日本臨床腎移植学会
ISSN： 2187-9907
ヒト羊膜由来細胞を用いた細胞移植治療法確立に向けて

戸子台和哲, 田中美也子, 岡田薫, 星合哲郎, 齋藤昌利, 海野倫明, 三木敏生, 亀井尚, 後藤昌史

Organ Biology　29　(2)　124-127　2022/07
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204

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胎盤由来の生体材料は古くから実臨床に使用され、羊膜移植はすでに眼科領域で実施されている。羊膜由来細胞は安価かつ大量に採取が可能であるため、ドナー不足のため普及が進まない肝細胞移植を代替できる細胞ソースであると考えられる。羊膜由来細胞を用いた再生医療の応用、先天性代謝異常症への臨床応用に向けた課題、門脈内細胞移植後に引き起こされる即時型炎症反応と免疫応答について概説した。
Long-term survival of an adult patient with undifferentiated embryonal sarcoma of the liver with multidisciplinary treatment: a case report and literature review. International-journal

Yukiko Kumata Endo, Atsushi Fujio, Keigo Murakami, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Kazuaki Tokodai, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

Surgical case reports　8　(1)　85-85　2022/05/05

DOI： 10.1186/s40792-022-01436-3 　

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BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) primarily occurs in children; it is rarely seen in adults and appears to have a poor prognosis. However, in recent years, some cases indicated that long-term survival was possible due to a combination of multiple surgeries, chemotherapy, and liver transplantation. CASE PRESENTATION: A 33-year-old female patient presented with a complaint of epigastric pain, for which she underwent a medical examination. Computed tomography (CT) and magnetic resonance imaging showed a cystic tumor in the right hepatic lobe, approximately 10 cm in size. During observation, the abdominal pain worsened, and a contrast-enhanced CT revealed that the tumor's peripheral solid components increased in size and volume, suggesting a malignant tumor threatening hepatic rupture. Subsequently, transcatheter arterial embolization of the anterior and posterior segmental branches of the hepatic artery was performed, followed by right trisectionectomy. Histopathological and immunohistochemical examinations of the lesion revealed UESL. Two months after the surgery, we initiated sarcoma-directed chemotherapy with doxorubicin because of multiple metastases to the liver. After initiating the chemotherapy, she received another regimen using gemcitabine/docetaxel, eribulin, trabectedin, ifosfamide/mesna, pazopanib, and cisplatin. During the chemotherapy, she underwent palliative surgery twice due to the progressive disease. She lived for 49 months after the initial operation. CONCLUSIONS: Improved long-term survival was achieved in an adult patient with UESL after multidisciplinary therapy, involving a combination of three surgical procedures and several chemotherapies.
持続可能社会における外科医の働き方男女ともに輝き続けるために必要なこと

柏舘俊明, 宮城重人, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 金井哲史, 西牧宏泰, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　122回　SP-2　2022/04
Publisher: (一社)日本外科学会
米国での移植外科クリニカルフェローを経験して

松村宗幸, 宮城重人, 戸子台和哲, 柏舘俊明, 藤尾淳, 宮澤恒持, 佐々木健吾, 金井哲史, 西牧宏泰, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　FS-5　2022/04
Publisher: (一社)日本外科学会
胆道閉鎖症患者における移植機会喪失の可能性とその回避方法

佐々木健吾, 西牧宏泰, 宮崎勇希, 松村宗幸, 宮澤恒持, 柏館俊明, 藤尾淳, 戸子台和哲, 宮城重人, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　SF-2　2022/04
Publisher: (一社)日本外科学会
手術侵襲が肝細胞癌に対する初回肝切除の予後に与える影響の検討

西牧宏泰, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　DP-6　2022/04
Publisher: (一社)日本外科学会
当院における肝線維化F4症例に対する腹腔鏡下肝切除の検討

宮澤恒持, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 佐々木健吾, 松村宗幸, 金井哲史, 西牧宏泰, 森川孝則, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　122回　DP-4　2022/04
Publisher: (一社)日本外科学会
巨大悪性褐色細胞腫に対しハイブリット室にて栄養血管塞栓後に腫瘍摘出術を行った一例

飯塚友理子, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 宮城重人, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　RS-8　2022/04
Publisher: (一社)日本外科学会
術後3年経過し異時性副腎転移として出現した転移性肺癌の一例

菊地貴大, 西牧宏泰, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　RS-9　2022/04
Publisher: (一社)日本外科学会
肝胆膵領域における再生医療研究の最前線羊膜由来幹細胞を用いた肝・膵機能不全に対する細胞移植治療法の確立

戸子台和哲, 田中美也子, 佐藤将人, 岡田薫, 星合哲郎, 齋藤昌利, 宮城重人, 三木敏生, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　WS-5　2022/04
Publisher: (一社)日本外科学会
ヒト羊膜のラット虚血性潰瘍モデルにおける創傷治癒効果と血管新生促進効果の検討

佐藤将人, 戸子台和哲, 菅原宏文, 今野裕司, 田中美也子, 岡田薫, 小笠原弘之, 齋藤昌利, 星合哲郎, 宮城重人, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　122回　SF-3　2022/04
Publisher: (一社)日本外科学会
A potential preventive method for scar stenosis after esophageal endoscopic mucosal resection using human amniotic epithelial cells in a porcine model. International-journal

Yuji Konno, Chiaki Sato, Kazuaki Tokodai, Masatoshi Saito, Tetsuro Hoshiai, Yusuke Taniyama, Hiroshi Okamoto, Toshiaki Fukutomi, Yohei Ozawa, Naoto Ujiie, Ken Koseki, Ryohei Ando, Kozue Takahashi, Yasuharu Shinozaki, Michiaki Unno, Takashi Kamei

DEN open　2　(1)　e104　2022/04

DOI： 10.1002/deo2.104 　

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Objectives: The current methods employed for esophageal endoscopic mucosal resection (EMR) involve the risk of adverse postprocedural complications. Therefore, this study aimed to develop a new method to prevent stenosis following a resection procedure using human amniotic epithelial cells in a porcine model. Methods: With the consent of a woman who underwent a cesarean section, amniotic epithelial cells were isolated from the amniotic membrane of the delivered placenta. Six swine were used for this study. Under general anesthesia, four EMRs using cap-fitted microscope ulcers were performed on each porcine esophagus. Of the four ulcers, the two on the oral side were treated by injecting human amniotic epithelial (AE group) cells, and the remaining two on the anal side were left untreated (control group). One week after the procedure, the swine were sacrificed, and the ulcers were evaluated. The epithelialization rate was calculated by dividing the length of the epithelialized portion of each section by the length of the ulcer, which was determined using an optical microscope. Moreover, the mucosal thickening in each section was measured in terms of diameter. Results: The epithelialization rate was significantly higher in the AE group than in the control group. Mucosal thickening was not significantly different between the groups. Conclusions: Transplanting amniotic epithelial cells into the ulcer promoted ulcer epithelialization. Amniotic epithelial cell transplantation is a potential method for the management of ulcer scar stenosis following esophageal endoscopic submucosal dissection.
Oxygenated Hypothermic Machine Perfusion of Kidney Transplantation from Donors After Cardiac Death Due to Long-Term Low Blood Pressure and Hypoxia: The First Case Report of a Clinical Trial Using a New Japanese Perfusion System. International-journal

Shigehito Miyagi, Toshiaki Kashiwadate, Hiroyasu Nishimaki, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Muneyuku Matsumura, Michiaki Unno, Takashi Kamei, Naoto Matsuno

Transplantation proceedings　54　(2)　225-229　2022/03

DOI： 10.1016/j.transproceed.2021.09.075 　

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BACKGROUND: Machine perfusion of marginal kidney grafts obtained from donors after cardiac death (DCD) has become a standard therapy worldwide. However, the use of grafts from DCD due to long-term low blood pressure is associated with a high incidence of primary graft nonfunction. Furthermore, the importance of oxygenation in machine perfusion remains unclear. We report the first case of a clinical trial of a kidney transplant obtained from a DCD using a Japanese oxygenated hypothermic perfusion system (CMX-08W, Chuo Seiko Co Ltd, Asahikawa, Japan). PATIENTS AND METHODS: The donor was a 61-year-old man with amyotrophic lateral sclerosis. His SpO2 decreased to 80% to 90%, his blood pressure remained consistently low for 4 hours and 30 minutes, and he suffered a cardiac arrest. Subsequently, we carried him to the operating room. The warm ischemic time was 12 minutes, and the cold ischemic time was 418 minutes. The recipient was a 58-year-old man who had been undergoing hemodialysis for 26 years. He was diagnosed with nephrosclerosis and multiple renal cysts. Oxygenated hypothermic machine perfusion was used on the kidney transplant obtained from the DCD. RESULTS: The recipient gradually recovered and was withdrawn from hemodialysis therapy 14 days post transplantation. His renal function improved, and he was discharged on postoperative day 36. Currently, his renal function remains good (phosphocreatine, 1.7). CONCLUSIONS: Oxygenated machine perfusion is used to preserve organs and determine if an organ is suitable for transplantation. This may provide the possibility of perfusion preservation and expand the criteria for cardiac arrest-associated renal transplantation.
Usefulness of Thiel-Embalmed Cadavers for Training in Organ Procurement. International-journal

Hiroaki Mitsugashira, Kazuaki Tokodai, Wataru Nakanishi, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Shigehito Miyagi, Yuji Owada, Michiaki Unno, Takashi Kamei

Transplantation proceedings　54　(2)　230-232　2022/03

DOI： 10.1016/j.transproceed.2021.10.026 　

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BACKGROUND: The number of brain-dead donors has been increasing; however, the opportunity for young surgeons to experience deceased donor surgeries is extremely limited, especially in many Asian countries including Japan. Deceased donor surgeries require unique surgical skills and knowledge; however, it is difficult to provide on-the-job guidance and education. Therefore, cadaver training is meaningful and suitable for the training of deceased donor surgeries. Thiel's embalming method (TEM) provides natural coloration, flexibility, and tissue plasticity, and is widely used for cadaver surgical training. In this study, we evaluated the usefulness of Thiel's embalmed cadaver training for organ procurement surgery. MATERIAL AND METHODS: Each trainee performed hepatectomy, pancreatectomy, and nephrectomy using conventional open techniques. Faculty experts of transplantation surgery and organ procurement took attendees through surgical steps. After the procedure, all participants were asked to complete a voluntary, anonymous survey, consisting of a 10-point satisfaction scale, to evaluate their perceptions of the training. RESULTS: A total of 33 gastrointestinal surgeons participated in the training program for procuring the liver, pancreas, and kidneys. In the questionnaire administered to the participants, the evaluation was generally satisfactory, with an average of 9.1 points on the 10-point scales. Some participants expressed that Thiel-embalmed cadavers are more suitable for training on organ procurement compared with animals used in wet-lab training. CONCLUSION: We conclude that organ procurement training in human cadavers preserved by TEM is useful and suitable for practicing deceased donor organ procurement, especially in countries where deceased donors are not common, as in Japan.
Adult Living Donor Liver Transplantation for the Carryover Patients After Kasai Operation Who Have a History of Multiple Laparotomies. International-journal

Shigehito Miyagi, Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Takashi Kamei, Michiaki Unno

Transplantation proceedings　54　(2)　430-434　2022/03

DOI： 10.1016/j.transproceed.2021.09.073 　

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OBJECTIVE: Approximately 50 years have passed since the Kasai operation announcement for biliary atresia. In adult liver failure cases, the so-called "the carryover cases after Kasai operation" have increased. These patients often underwent polysurgery. In such cases, adult living-donor liver transplantation (LDLT) is occasionally difficult. Many complications have been reported to be caused by severe cholangitis, hepatic portal regional inflammation, and adhesion. We investigated the complications of adult LDLT in post-Kasai biliary atresia cases with polysurgery. METHODS: Between 1991 and 2021, we performed 205 LDLT cases. We investigated the outcome of adult LDLT for post-Kasai biliary atresia cases (transplanted over 16 years old) (n = 20) and the risk factors for complications after LDLT. RESULTS: On 5 years overall survival, there were no significant differences between "adult LDLT for post-Kasai" group and the others (81.8% vs 81.2%). Adult LDLT for post-Kasai was not found to be a risk factor for complications. However, polysurgery before LDLT was an independent risk factor for biliary stenosis and portal stenosis, as identified in our univariate and multivariate analysis. We analyzed the relationship between biliary stenosis and the frequency of laparotomies using a receiver operating characteristic curve. The analysis showed that the cutoff point (maximum point of sensitivity plus specificity) was more than 3 times that of laparotomies before LDLT. CONCLUSIONS: In our study, adult LDLT for post-Kasai cases was not a risk factor for any complications. However, polysurgery before LDLT has been identified as a risk factor for biliary stenosis and portal vein stenosis.
Optimal Conditions for Oxygenated Subnormothermic Machine Perfusion for Liver Grafts Using a Novel Perfusion Device. International-journal

Hiroyasu Nishimaki, Shigehito Miyagi, Toshiaki Kashiwadate, Kazuaki Tokodai, Atsushi Fujio, Koji Miyazawa, Kengo Sasaki, Takashi Kamei, Michiaki Unno

Transplantation proceedings　54　(2)　217-224　2022/03

DOI： 10.1016/j.transproceed.2021.12.025 　

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BACKGROUND: Liver transplantation from donors after cardiac death (DCD) resolves donor shortages. PURPOSE: We investigated the optimal time for subnormothermic oxygenated perfusion in DCD liver transplantation. METHODS: Ten F1 pigs (body weight: 27-32 kg) were allocated to 2 groups: the heart beating group (n = 6), from which livers were retrieved while the heart was beating, and the donation after cardiac death (DCD) group (n = 4), in which liver retrieval was performed on pigs under apnea-induced cardiac arrest for 20 minutes. In both groups, the livers were kept in cold storage for 2 hours after retrieval and perfused with a subnormothermic oxygenated Krebs-Henseleit buffer for 120 minutes. We used a novel perfusion device, which can set maximum perfusion pressures of arteries and portal vein, developed by Asahikawa Medical University and Chuo Seiko Co. Bile production, liver enzymes, and inflammatory cytokines were measured and the sinusoidal space, using tissue specimens taken from liver grafts, was measured at 30, 60, 90, and 120 minutes after the start of perfusion. RESULTS: Bile production peaked at 90 minutes. Significantly higher levels of liver enzymes and inflammatory cytokines were found in the DCD group (P < .05). The release of liver enzymes peaked at 60 minutes and that of inflammatory cytokines peaked at 90 minutes. The hepatic sinusoidal space was wide at 90 minutes and narrowed after 120 minutes. CONCLUSIONS: The results suggest that subnormothermic oxygenation perfusion may maintain optimal graft condition until around 90 minutes and perfusion for more than 120 minutes may be counterproductive.
Cholesterol Granuloma of the Liver Mimicking Malignant Tumor: A Case Report.

Yuki Ishikawa, Atsushi Fujio, Kazuaki Tokodai, Toshiaki Kashiwadate, Koji Miyazawa, Kengo Sasaki, Muneyuki Matsumura, Yoshikatsu Saitoh, Mio Tsuruoka, Jun Inoue, Shigehito Miyagi, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

The Tohoku journal of experimental medicine　256　(3)　235-240　2022/03

DOI： 10.1620/tjem.256.235 　

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Cholesterol granuloma is a benign, tumor-like lesion with an accumulation of cholesterol crystals in the tissue and is a consequence of a chronic inflammatory reaction. It commonly occurs in the middle ear but rarely in the liver. There is only one previous case report of cholesterol granuloma of the liver, which was caused by cholesterol hepatolithiasis. We report a case of cholesterol granuloma of the liver in a patient with no intrahepatic cholesterol stones; it was difficult to rule out malignant liver tumor preoperatively. The patient was a 79-year-old woman in whom a lesion in the liver was detected on abdominal ultrasonography. She was referred to our hospital for detailed examination and treatment. Abdominal contrast-enhanced computed tomography showed a 20 mm lesion with ring enhancement in the lateral segment of the liver during the arterial and delayed phases. Since a malignant tumor could not be ruled out radiologically, laparoscopic lateral segment hepatectomy was performed for definitive diagnosis and treatment. The resection specimen showed a yellowish-white lesion measuring 15 mm in diameter. Pathological examination showed a granulomatous lesion with cholesterol crystals surrounded by foreign body giant cells. The lesion was diagnosed as cholesterol granuloma of the liver. The postoperative course was good, and the patient was discharged on postoperative day 5. She was healthy, and no recurrence of the cholesterol granuloma was detected at the 5-month follow-up. This is the first case report of cholesterol granuloma of the liver mimicking a malignant liver tumor in a patient with no intrahepatic cholesterol stones.
Novel technique for recanalization of severe hepaticojejunal obstruction using a transseptal needle in a pediatric liver transplant recipient

Kengo Sasaki, Hideki Ota, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Koji Miyazawa, Muneyuki Matsumura, Yoshikatsu Saitoh, Norifumi Kanai, Hiroyasu Nishimaki, Kei Takase, Michiaki Unno, Takashi Kamei

Pediatric Transplantation　26　(2)　2022/03

DOI： 10.1111/petr.14160 　

ISSN： 1397-3142

eISSN： 1399-3046
CMVハイリスク症例に対しエベロリムスを使用した5症例の検討

戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 宮城重人, 海野倫明, 亀井尚

日本臨床腎移植学会プログラム・抄録集　55回　210-210　2022/02
Publisher: (一社)日本臨床腎移植学会
脳死肺移植後の末期腎不全に対し生体腎移植を施行した1例

齋藤純健, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 渡邊有為, 宮城重人, 岡田克典, 海野倫明, 亀井尚

日本臨床腎移植学会プログラム・抄録集　55回　200-200　2022/02
Publisher: (一社)日本臨床腎移植学会
Distribution of Amniotic Epithelial Cells After Intraportal Infusion in a Rat Model. International-journal

Miyako Tanaka, Kazuaki Tokodai, Masato Sato, Shuhei Yamada, Hitomi Okita, Takako Ito, Masatoshi Saito, Tetsuro Hoshiai, Shigehito Miyagi, Toshio Miki, Michiaki Unno, Takashi Kamei, Masafumi Goto

Transplantation proceedings　54　(2)　513-515　2022/01/13

DOI： 10.1016/j.transproceed.2021.09.077 　

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BACKGROUND: Human amniotic epithelial cells (hAECs) are increasingly gaining attention as novel sources for cell transplantation. In clinical practice, intraportal infusion is considered one of the leading approaches for transplantation; however, this has not yet been validated for in vivo transplantation of hAECs. Thus, this study aims to investigate the distribution of hAECs post intraportal infusion and compare this distribution with other cell administration routes. METHODS: Wistar/ST rats were divided into 4 groups (n = 3 for each) based on cell administration route: group 1, intraportal; group 2, the spleen; group 3, tail veins; and group 4, penile veins. Subsequently, hAECs (1 × 107) stained with XenoLight DiR were infused into each recipient. Cell distribution was evaluated using an in vivo imaging system. RESULTS: DiR signals were detected in the rat livers of groups 1 and 2 with those in group 2 being much weaker than those in group 1. Necrosis of small intestine was observed in 2 cases in group 2. DiR signals were detected in the lungs in groups 3 and 4 because of systemic circulation; however, all the animals died within 20 minutes of infusions. CONCLUSIONS: Intraportal infusion is potentially applicable for safe and efficient transplantation of hAECs into the liver, whereas hAECs administration via the spleen carries a risk of thrombosis in a narrow portal vein system. Our results also indicate that hAECs administration via the systemic circulation could cause pulmonary embolism in clinical settings.
Doppler ultrasonography is a useful tool for the diagnosis of hemodynamics in congestive graft injury due to heart failure after liver transplantation: A case report

Kengo Sasaki, Kazuaki Tokodai, Atsushi Fujio, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

International Journal of Surgery Case Reports　88　106569-106569　2021/11
Publisher: Elsevier BV
DOI： 10.1016/j.ijscr.2021.106569 　

ISSN： 2210-2612
移植後de novo発がんに関する諸問題当院における肝移植後de novo発癌についての検討

金井哲史, 藤尾淳, 西牧宏泰, 齋藤純健, 松村宗幸, 佐々木健吾, 宮澤恒持, 柏舘俊明, 戸子台和哲, 宮城重人, 海野倫明, 亀井尚

日本臨床外科学会雑誌　82　(増刊)　S234-S234　2021/10
Publisher: 日本臨床外科学会
ISSN： 1345-2843

eISSN： 1882-5133
悪性腫瘍との鑑別が困難であり腹腔鏡下肝切除術を施行した肝コレステロール肉芽腫の1例

石川裕貴, 藤尾淳, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 宮城重人, 海野倫明, 亀井尚

日本臨床外科学会雑誌　82　(増刊)　S776-S776　2021/10
Publisher: 日本臨床外科学会
ISSN： 1345-2843

eISSN： 1882-5133
ヒト羊膜由来細胞移植後の即時型炎症反応と免疫応答の解析と制御

戸子台和哲, 田中美也子, 佐藤将人, 山田修平, 齋藤昌利, 星合哲郎, 宮城重人, 三木敏生, 海野倫明, 亀井尚, 後藤昌史

Organ Biology　28　(3)　93-93　2021/10
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204
肝細胞癌に対する開腹肝切除における術前栄養評価としてのControlling nutritional status(CONUT)値の意義

藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 斎藤純健, 金井哲史, 海野倫明, 亀井尚

外科と代謝・栄養　55　(4)　109-109　2021/09
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
組織学的評価を踏まえ腎移植マージナルドナーの適格性を判断した1例

石岡広崇, 牧野塁, 吉田舞, 大江佑治, 岡本好司, 長澤将, 宮崎真理子, 戸子台和哲, 宮城重人, 佐藤博

日本腎臓学会誌　63　(6-E)　724-724　2021/09
Publisher: (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
高齢患者に対する栄養・運動介入法とそのアウトカム高齢者に対する腹腔鏡下肝切除術における手術リスク評価についての検討

岡田薫, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 海野倫明, 亀井尚

外科と代謝・栄養　55　(4)　69-69　2021/09
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
侵襲時の生体反応の制御〜その理論と実践〜肝細胞癌に対する腹腔鏡下肝切除術における硬膜外麻酔の周術期管理に及ぼす影響に関する検討

西牧宏泰, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 海野倫明, 亀井尚

外科と代謝・栄養　55　(4)　89-89　2021/09
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

佐々木健吾, 金井哲史, 齋藤純健, 松村宗幸, 宮澤恒持, 柏舘俊明, 藤尾淳, 戸子台和哲, 宮城重人, 亀井尚, 海野倫明

移植　56　(総会臨時)　O2-1　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
移植後EBウイルス感染症当院における生体肝移植後リンパ増殖性疾患成人および小児症例の解析

松村宗幸, 宮城重人, 戸子台和哲, 柏舘俊明, 藤尾淳, 宮澤恒持, 佐々木健吾, 斎藤純健, 金井哲史, 海野倫明, 亀井尚

移植　56　(総会臨時)　CWS2-4　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
移植外科医・コーディネーターの働き方改革(互助制度を視野に入れて) 東北大学における脳死臓器摘出互助化の推進と摘出手技教育プログラムの構築肝膵腎小腸の摘出チームにおける試み

宮澤恒持, 宮城重人, 戸子台和哲, 柏舘俊明, 藤尾淳, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　CSY2-5　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
生体肝ドナーの安全性向上(腹腔鏡下手術の適応も含む) 当科の生体肝移植ドナーへの安全性と低侵襲性への取り組み

藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 斎藤純健, 金井哲史, 海野倫明, 亀井尚

移植　56　(総会臨時)　SSY6-3　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
悪性腫瘍に対する生体肝移植-肝細胞癌に対する適応拡大、肝門部領域胆管癌、転移性肝癌局所進行肝門部領域胆管癌に対する肝移植適応の検討

宮城重人, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　SWS5-1　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
当院における血液型不適合肝移植の現状

柏舘俊明, 宮城重人, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　P2-9　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植における慢性抗体関連拒絶の意義と治療介入の試み

戸子台和哲, 宮城重人, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 海野倫明, 後藤昌史, 亀井尚

移植　56　(総会臨時)　P2-10　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
生体移植における家族ケア生体肝移植におけるドナーケア

宮城重人, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 亀井尚, 海野倫明

移植　56　(総会臨時)　CWS7-4　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植後長期経過症例における血清Mac-2結合蛋白蛋白糖鎖修飾異性体濃度と移植肝線維化の関連に関する検討

戸子台和哲, 宮城重人, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 亀井尚, 海野倫明

肝臓　62　(Suppl.2)　A537-A537　2021/09
Publisher: (一社)日本肝臓学会
ISSN： 0451-4203

eISSN： 1881-3593
当院における肝移植レシピエント、生体ドナー候補者の後方視的検討

佐々木健吾, 金井哲史, 齋藤純健, 松村宗幸, 宮澤恒持, 柏舘俊明, 藤尾淳, 戸子台和哲, 宮城重人, 亀井尚, 海野倫明

移植　56　(総会臨時)　O2-1　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
移植外科医・コーディネーターの働き方改革(互助制度を視野に入れて) 東北大学における脳死臓器摘出互助化の推進と摘出手技教育プログラムの構築肝膵腎小腸の摘出チームにおける試み

宮澤恒持, 宮城重人, 戸子台和哲, 柏舘俊明, 藤尾淳, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　CSY2-5　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
悪性腫瘍に対する生体肝移植-肝細胞癌に対する適応拡大、肝門部領域胆管癌、転移性肝癌局所進行肝門部領域胆管癌に対する肝移植適応の検討

宮城重人, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　SWS5-1　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
当院における血液型不適合肝移植の現状

柏舘俊明, 宮城重人, 戸子台和哲, 藤尾淳, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 亀井尚, 海野倫明

移植　56　(総会臨時)　P2-9　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植における慢性抗体関連拒絶の意義と治療介入の試み

戸子台和哲, 宮城重人, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 海野倫明, 後藤昌史, 亀井尚

移植　56　(総会臨時)　P2-10　2021/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
高齢患者に対する栄養・運動介入法とそのアウトカム高齢者に対する腹腔鏡下肝切除術における手術リスク評価についての検討

岡田薫, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 海野倫明, 亀井尚

外科と代謝・栄養　55　(4)　69-69　2021/09
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
侵襲時の生体反応の制御〜その理論と実践〜肝細胞癌に対する腹腔鏡下肝切除術における硬膜外麻酔の周術期管理に及ぼす影響に関する検討

西牧宏泰, 藤尾淳, 宮城重人, 戸子台和哲, 柏舘俊明, 宮澤恒持, 佐々木健吾, 松村宗幸, 齋藤純健, 金井哲史, 海野倫明, 亀井尚

外科と代謝・栄養　55　(4)　89-89　2021/09
Publisher: 日本外科代謝栄養学会
ISSN： 0389-5564

eISSN： 2187-5154
本邦における膵臓移植・膵島移植の位置づけ当院における膵臓移植・膵島移植の位置づけ

宮城重人, 後藤昌史, 戸子台和哲, 藤尾淳, 柏舘俊明, 宮澤恒持, 佐々木健吾, 亀井尚, 海野倫明

膵臓　36　(3)　A269-A269　2021/08
Publisher: (一社)日本膵臓学会
ISSN： 0913-0071

eISSN： 1881-2805
ABO-incompatible living donor liver transplantation with high preoperative antibody titer: A case report. International-journal

Yoshikatsu Saitoh, Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Michiaki Unno, Takashi Kamei

International journal of surgery case reports　85　106260-106260　2021/08

DOI： 10.1016/j.ijscr.2021.106260 　

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INTRODUCTION AND IMPORTANCE: ABO-incompatible living donor liver transplantation (ABOi-LDLT) is essential for expanding the donor pool. ABOi-LDLT prognosis has improved since desensitization treatment with rituximab; however, patients with high antibody titers are considered to be at high risk of antibody mediated rejection (AMR). Nevertheless, the preoperative antibody titer cutoff levels that preclude ABOi-LDLT have not yet been determined. In this study, the highest preoperative antibody titer was 1:4096, and the recipient had good outcomes. There has been only one report of good outcomes with a preoperative antibody titer of more than 1:4096. We hypothesized that high preoperative antibody titers in ABOi-LDLT may not be associated with AMR in protocols involving rituximab. CASE PRESENTATION: The recipient was a 22-year-old man with biliary atresia and underwent ABOi-LDLT (B to O). We administered 500 mg of rituximab 14 days prior and then 300 mg of rituximab one day prior to ABOi-LDLT. The recipients preoperative IgG antibody titer was 1:4096. Postoperative immunosuppressive protocol involved steroids, tacrolimus, and mycophenolate mofetil. The patient had satisfactory graft function three years following ABOi-LDLT. CLINICAL DISCUSSION: The antibody that is responsible for posttransplant AMR should be newly synthesized after transplantation as a result of sensitization by antigens on the vascular endothelial cells of the graft. In ABOi-LDLT, natural antibodies may not cause AMR. CONCLUSIONS: The most important factor for preventing AMR in recipients undergoing ABOi-LDLT is the suppression of de novo antibodies. High preoperative antibody titers may not necessarily preclude ABOi-LDLT, provided that rituximab is used in desensitization.
多施設臨床研究国内第一例目となる、酸素化灌流保存装置を使用した心停止ドナー腎移植の報告

宮城重人, 柏舘俊明, 西牧宏泰, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 亀井尚, 海野倫明, 松野直徒

移植　56　(1)　69-74　2021/07
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034

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50歳代、男性。24年前より腎移植の待機中であった。今回、心停止ドナー発生を受け、2位で臓器にマッチングし、当院での腎移植手術施行予定となった。ドナーとの組織適合性検査は1ミスマッチのみ、クロスマッチは陰性であった。心停止ドナー腎は酸素化灌流保存装置を用いて移植前2時間の低温酸素化灌流を行い、安全に腎移植を施行し得た。移植術後は免疫抑制剤の投与、計5回の透析を行い、腎機能は良好に経過し、第35病日に退院となった。
ヒト羊膜のラット虚血性潰瘍モデルに対する創傷治癒効果の検討

佐藤将人, 戸子台和哲, 田中美也子, 小笠原弘之, 菅原宏文, 齋藤昌利, 星合哲郎, 宮城重人, 海野倫明, 後藤昌史, 亀井尚

日本組織移植学会雑誌　19　(1)　39-39　2021/07
Publisher: 日本組織移植学会
ISSN： 1347-6491
ラットに対する経門脈的ヒト羊膜上皮細胞移植後の細胞分布および分化生着の検討

田中美也子, 戸子台和哲, 佐藤将人, 齋藤昌利, 星合哲郎, 宮城重人, 三木敏生, 海野倫明, 亀井尚, 後藤昌史

日本組織移植学会雑誌　19　(1)　40-40　2021/07
Publisher: 日本組織移植学会
ISSN： 1347-6491
ヒト羊膜上皮細胞を用いた食道ESD後潰瘍瘢痕狭窄予防法の開発に関する研究

今野裕司, 佐藤千晃, 戸子台和哲, 齋藤昌利, 星合哲郎, 岡本宏史, 福富俊明, 谷山裕亮, 海野倫明, 亀井尚

日本組織移植学会雑誌　19　(1)　41-41　2021/07
Publisher: 日本組織移植学会
ISSN： 1347-6491
高齢者に対する腹腔鏡下肝切除の検討

齋藤純健, 藤尾淳, 宮城重人, 戸子台和哲, 中西渉, 柏舘俊明, 宮澤恒持, 佐々木健吾, 海野倫明, 亀井尚

日本消化器外科学会総会　76回　P163-6　2021/07
Publisher: (一社)日本消化器外科学会
Living donor liver transplantation for Budd‒Chiari syndrome with right posterior segment graft and patch plasty using the superficial femoral vein: a case report. International-journal

Norikazu Une, Kazuaki Tokodai, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Atsushi Fujio, Wataru Nakanishi, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

Surgical case reports　7　(1)　136-136　2021/06/04

DOI： 10.1186/s40792-021-01224-5 　

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BACKGROUND: In living donor liver transplantation (LDLT) for patients with Budd‒Chiari syndrome (BCS), there are several concerns about reconstruction of the inferior vena cava (IVC) and hepatic veins. Herein, we report the case of a patient with BCS who underwent LDLT with right posterior segment graft (RPSG) and patch plasty for reconstruction of the hepatic venous outflow, using the patient's own superficial femoral vein (SFV). CASE PRESENTATION: A 19-year-old man, who was diagnosed with primary BCS, underwent LDLT. His main hepatic veins were totally obstructed, and membranous stenosis was seen in the IVC. The LDLT donor was his mother; however, liver volumetric analysis showed that only her RPSG was appropriate. In the recipient surgery, 16 cm of the left SFV was harvested and was cut longitudinally and opened. The right hepatic vein (RHV) of the RPSG was anastomosed to the sidewall of the SFV graft. After explantation of native diseased liver was completed, the stenotic and thickened wall of the IVC was widely resected, and a large anastomotic orifice was created. Patch cavoplasty was performed with the RHV‒SFV graft patch. After portal reperfusion started, hepatic venous outflow was satisfactory, and there was no venous graft congestion. Both his postoperative course and his long-term course after discharge were uneventful. CONCLUSIONS: In LDLT for BCS patients, ingenuity is required for the reconstruction of venous outflow. The SFV patch can be safely harvested from liver transplant recipients and is suitable for venous reconstruction. In addition, RPSG is an alternative type of liver graft for LDLT if a conventional right- or left-lobe graft cannot be used.
Laparoscopic liver cyst fenestration with real-time indocyanine green fluorescence-guided surgery: a case report. International-journal

Norikazu Une, Atsushi Fujio, Hiroaki Mitsugashira, Norifumi Kanai, Yoshikatsu Saitoh, Mineto Ohta, Kengo Sasaki, Koji Miyazawa, Toshiaki Kashiwadate, Wataru Nakanishi, Kazuaki Tokodai, Shigehito Miyagi, Michiaki Unno, Takashi Kamei

Journal of surgical case reports　2021　(5)　rjab196　2021/05

DOI： 10.1093/jscr/rjab196 　

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Laparoscopic fenestration (LF) has recently been considered a standard procedure for nonparasitic symptomatic liver cysts. Here, we report a case of LF that was safely performed using real-time indocyanine green (ICG) fluorescence-guided surgery. A 74-year-old woman presented with right upper abdominal pain and poor dietary intake. The patient was diagnosed with symptomatic liver cysts and underwent LF. One hour before surgery, ICG (2.5 mg) was intravenously administered to the patient. ICG fluorescence imaging clearly showed the biliary ducts and distinguished the cysts from the liver parenchyma. We could resect only the cyst walls as wide as possible under the guidance of both white light and fluorescence imaging. There were no signs of postoperative symptom recurrence. Detection of ICG fluorescence in the liver parenchyma is as important as ICG cholangiography for fenestration. Laparoscopic liver cyst fenestration with real-time ICG fluorescence-guided surgery is safe and can be used as a standard procedure.
脳死下膵腎同時移植により治療した1型糖尿病の15例の長期経過

高橋圭, 遠藤彰, 戸子台和哲, 黒澤聡子, 川名洋平, 畑山暁子, 金子慶三, 宮城重人, 今井淳太, 亀井尚, 片桐秀樹

糖尿病　64　(4)　299-299　2021/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
肝門部領域胆管癌に対する肝移植-for vs against- 局所進行肝門部領域胆管癌に対する肝移植の意義

宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 佐々木健吾, 益田邦洋, 中川圭, 森川孝則, 大沼忍, 石田孝宣, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　121回　DB-1　2021/04
Publisher: (一社)日本外科学会
当科での肝・膵移植における術前リツキシマブ脱感作療法の成績と課題

柏舘俊明, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 佐々木健吾, 西村隆一, 小笠原弘之, 大沼忍, 石田孝宣, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　121回　SF-5　2021/04
Publisher: (一社)日本外科学会
当院における小児肝移植の現状と今後の課題

佐々木健吾, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　121回　PS-5　2021/04
Publisher: (一社)日本外科学会
東北地方における臓器提供増加にむけた取り組みと課題について移植外科医の立場から

藤尾淳, 宮城重人, 小笠原弘之, 佐々木健吾, 柏舘俊明, 中西渉, 西村隆一, 戸子台和哲, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　121回　PS-7　2021/04
Publisher: (一社)日本外科学会
Surgical resection for liver metastasis and local recurrence of pheochromocytoma 16 years after primary surgery: A case report. International-journal

Mineto Ohta, Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanisihi, Michiaki Unno, Takashi Kamei

International journal of surgery case reports　81　105712-105712　2021/04

DOI： 10.1016/j.ijscr.2021.105712 　

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INTRODUCTION AND IMPORTANCE: Pheochromocytomas arise from the adrenal medulla and are rare. Pheochromocytomas metastasize to bone, lung and liver, and surgery might be the curative treatment. However, few cases are detected when they are resectable lesions because of difficulty in diagnosis and rapid growth. We herein report a patient who underwent resection of liver metastasis and local recurrence of pheochromocytoma. CASE PRESENTATION: A 74-year-old woman visited our hospital for treatment for liver and retroperitoneal tumors. She had undergone left adrenal gland resection for pheochromocytoma 16 years earlier. Eleven years after primary surgery, breast cancer was diagnosed and resected. During the breast cancer follow-up, a liver tumor was identified with computed tomography. Breast cancer recurrence and metastasis were considered, so chemotherapy was administered first. However, the liver tumor gradually enlarged, and another lesion appeared in the retroperitoneum. The tumors were diagnosed as pheochromocytoma recurrence using 123I-metaiodobenzylguanidine scintigraphy, and she underwent resection of the local recurrence and liver metastasis. She was discharged on postoperative day 25 without complications, and no evidence of recurrence occurred more than 3.5 years postoperatively. CLINICAL DISCUSSION: All pheochromocytomas have metastatic potential; however, there are no reliable markers to predict malignancy. Early detection of recurrence by regular imaging and complete resection are important in the treatment. If the recurrence was oligometastasis and tumor growth is slow, surgical resection may be eligible. CONCLUSION: A favorable outcome resulted from complete resection for liver metastasis and local recurrence of pheochromocytoma.
Bleeding from jejunal varices formed at the Roux-en-Y jejunum site caused by the compression of the left renal vein after living donor liver transplantation with renoportal anastomosis. International-journal

Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Toshiaki Kashiwadate, Kengo Sasaki, Yoshihiro Shono, Mineto Ohta, Yoshikatsu Saitoh, Michiaki Unno, Takashi Kamei

Surgical case reports　7　(1)　43-43　2021/02/06

DOI： 10.1186/s40792-021-01129-3 　

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BACKGROUND: Renoportal anastomosis is an option for the portal vein reconstruction of a liver transplantation with grade 4 portal vein thrombosis and a splenorenal shunt. Here, we report the case of gastrointestinal bleeding who underwent living donor liver transplantation (LDLT) with renoportal anastomosis. CASE PRESENTATION: Six-year-old female patient who underwent LDLT with renoportal anastomosis at 1 year of age had severe anemia with normal liver function during the follow-up period. The varices at the Roux-en-Y jejunum were considered the source of bleeding, and the compression of the left renal vein, which is known as a cause of Nutcracker syndrome, seemed to induce venous hypertension through the splenorenal shunt, which might induce the formation of the varices. She underwent percutaneous transhepatic sclerotherapy of the varices, and the anemia improved at her last follow-up, 6 months after sclerotherapy. This is the first reported case of Roux-en-Y jejunal varices bleeding related to the compression of the left renal vein after LDLT was performed with renoportal anastomosis. CONCLUSIONS: Although renoportal anastomosis should be cautiously performed when there are no options for severe portal vein thrombosis, the status of the left renal vein and new collateral formation should be observed carefully during the follow-up period in pediatric cases of renoportal anastomosis.
先天性代謝異常症の根治を目的とした羊膜由来細胞による新規細胞移植療法確立の試み

戸子台和哲, 沖田ひとみ, 吉田まなみ, 伊藤貴子, 佐藤将人, 田中美也子, 齋藤昌利, 星合哲郎, 宮城重人, 三木敏生, 海野倫明, 後藤昌史, 亀井尚, 東北大学病院臨床研究推進センター再生医療ユニット

日本小児科学会雑誌　125　(2)　201-201　2021/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
献腎移植増加の為に、心停止後腎提供を増加させるための方策酸素化灌流装置を用いた心停止腎移植の臨床研究国内一例目の報告

西牧宏泰, 宮城重人, 柏舘俊明, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 海野倫明, 亀井尚, 松野直従

日本臨床腎移植学会プログラム・抄録集　54回　65-65　2021/02
Publisher: (一社)日本臨床腎移植学会
先天性代謝異常症の根治を目的とした羊膜由来細胞による新規細胞移植療法確立の試み

戸子台和哲, 沖田ひとみ, 吉田まなみ, 伊藤貴子, 佐藤将人, 田中美也子, 齋藤昌利, 星合哲郎, 宮城重人, 三木敏生, 海野倫明, 後藤昌史, 亀井尚, 東北大学病院臨床研究推進センター再生医療ユニット

日本小児科学会雑誌　125　(2)　201-201　2021/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
生体肝移植における動脈門脈再建困難症例に対する戦略とpitfall

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 柿崎裕太, 小笠原弘之, 太田嶺人, 亀井尚, 海野倫明

日本消化器外科学会総会　75回　RS14-2　2020/12
Publisher: (一社)日本消化器外科学会
肝細胞癌に対する腹腔鏡下肝切除術における術後疼痛コントロールの検討

西牧宏泰, 藤尾敦, 宮城重人, 戸子台和哲, 西村隆一, 柿崎裕太, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　75回　RS21-2　2020/12
Publisher: (一社)日本消化器外科学会
Thiel法固定したご遺体を用いた脳死ドナー臓器摘出トレーニングの有用性

戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 大和田祐二, 海野倫明, 亀井尚

日本消化器外科学会総会　75回　RS22-1　2020/12
Publisher: (一社)日本消化器外科学会
再肝切除症例に対する確実なPringle法の施行と癒着防止に関する工夫

小笠原弘之, 藤尾淳, 西村隆一, 中西渉, 原康之, 戸子台和哲, 宮城重人, 海野倫明, 亀井尚

日本消化器外科学会総会　75回　RSV12-4　2020/12
Publisher: (一社)日本消化器外科学会
C型肝炎SVR症例における肝切除の検討

藤尾淳, 宮城重人, 太田嶺人, 小笠原弘之, 柿崎裕太, 西村隆一, 戸子台和哲, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　75回　P241-4　2020/12
Publisher: (一社)日本消化器外科学会
肝細胞癌症例に対する術前治療が肝切除に及ぼす影響についての検討

西村隆一, 宮城重人, 戸子台和哲, 藤尾淳, 柿崎裕太, 太田嶺人, 小笠原弘之, 海野倫明, 亀井尚

日本消化器外科学会総会　75回　P241-6　2020/12
Publisher: (一社)日本消化器外科学会
Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: a randomized clinical trial. International-journal

Wataru Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Atsushi Fujio, Kengo Sasaki, Yoshihiro Shono, Michiaki Unno, Takashi Kamei

Annals of surgical treatment and research　99　(6)　320-328　2020/12

DOI： 10.4174/astr.2020.99.6.320 　

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Purpose: Enhanced recovery after surgery (ERAS) is beneficial to patients undergoing digestive surgery. However, its efficacy in patients undergoing open hepatectomy remains unclear. Methods: Consecutive patients scheduled for open hepatectomy were randomly assigned to undergo either ERAS or conventional postoperative management. The primary endpoint was the amount of time that elapsed before patients were considered medically fit for discharge (MFD) and length of hospital stay (LOHS). Secondary endpoints included morbidity, mortality, the time to first flatus, defecation, first walk, and freedom from infusion. Perioperative serum nutritional markers, insulin resistance, respiratory quotient (RQ), and resting energy expenditure (REE) were also assessed. Results: Between August 2014 and March 2017, 57 patients were randomized into 2 groups; ERAS group (n = 29) and conventional management (n = 28). The median MFD was not significantly different between the ERAS and conventional management groups (6.5 vs. 7 days; P = 0.381). Recovery from gastrointestinal paresis was significantly quicker in the ERAS group (1.8 vs. 2.4 days; P = 0.004). There were no significant differences in serum markers, insulin resistance, RQ, and REE. Conclusion: This trial did not demonstrate greater efficacy of the ERAS protocol following open hepatectomy in terms of the MFD and LOHS. However, the ERAS protocol was associated with better recovery from postoperative gastrointestinal paresis, suggesting that it is useful for patients undergoing open hepatectomy.
脂肪肝合併肝移植ドナー候補に対する栄養療法

中西渉, 宮城重人, 戸子台和哲, 西村隆一, 藤尾淳, 佐々木健吾, 宮崎勇希, 笹嶋秀憲, 海野倫明, 亀井尚

学会誌JSPEN　2　(Suppl.1)　1344-1344　2020/11
Publisher: (一社)日本臨床栄養代謝学会
eISSN： 2434-4966
Renoportal再建を施行した生体肝移植後挙上空腸静脈瘤から消化管出血を来した一例

中西渉, 宮城重人, 戸子台和哲, 藤尾淳, 柏館俊明, 佐々木健吾, 菖野佳浩, 太田嶺人, 海野倫明, 亀井尚

移植　55　(総会臨時)　346-346　2020/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
肝移植におけるdnDSAの危険因子と免疫抑制療法再強化によるDSA抑制効果の検証

戸子台和哲, 宮城重人, 中西渉, 藤尾淳, 柏舘俊明, 佐々木健吾, 菖野佳浩, 太田嶺人, 小笠原弘之, 後藤昌史, 亀井尚, 海野倫明

移植　55　(総会臨時)　240-240　2020/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
高齢ドナー高齢レシピエントの肝移植術後経過における危険性の検討

宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 佐々木健吾, 菖野佳浩, 太田嶺人, 亀井尚, 海野倫明

移植　55　(総会臨時)　251-251　2020/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
当科のアルコール関連肝不全における肝移植後経過に関する検討

菖野佳浩, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 佐々木健吾, 太田嶺人, 海野倫明, 亀井尚

移植　55　(総会臨時)　278-278　2020/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
急性肝不全昏睡型の肝移植成績および予後不良因子の検討

宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 柏舘俊明, 佐々木健吾, 菖野佳浩, 太田嶺人, 亀井尚, 海野倫明

移植　55　(総会臨時)　280-280　2020/10
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
BCLC BのHCCに対する肝切除術の長期成績

中西渉, 宮城重人, 戸子台和哲, 藤尾淳, 柏館俊明, 菖野佳浩, 亀井尚, 海野倫明

肝臓　61　(Suppl.2)　A645-A645　2020/09
Publisher: (一社)日本肝臓学会
ISSN： 0451-4203

eISSN： 1881-3593
BCLC BのHCCに対する肝切除術の長期成績

中西渉, 宮城重人, 戸子台和哲, 藤尾淳, 柏館俊明, 菖野佳浩, 亀井尚, 海野倫明

肝臓　61　(Suppl.2)　A645-A645　2020/09
Publisher: (一社)日本肝臓学会
ISSN： 0451-4203

eISSN： 1881-3593
血行再建を伴う進行癌切除術の手術手技【Video】動脈合併切除再建を伴う局所進行肝胆膵癌における、安全性向上に向けた当科の挑戦

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 林洋毅, 中川圭, 元井冬彦, 内藤剛, 石田孝宣, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　120回　WS-5　2020/08
Publisher: (一社)日本外科学会
Risks of Living Donor Liver Transplantation Using Small-For-Size Grafts

Shigehito Miyagi, Yoshihiro Shono, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Kengo Sasaki, Yuki Miyazaki, Yuta Kakizaki, Hideaki Sasajima, Takashi Kamei, Michiaki Unno

Transplantation Proceedings　52　(6)　1825-1828　2020/07
Publisher: Elsevier BV
DOI： 10.1016/j.transproceed.2020.01.136 　

ISSN： 0041-1345
Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti-HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report. International-journal Peer-reviewed

Kengo Fukuoka, Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Hirofumi Watanabe, Shinji Taniuchi, Takeshi Naitoh, Takanori Ishida, Michiaki Unno, Takashi Kamei

Transplantation proceedings　52　(6)　1937-1939　2020/06/23

DOI： 10.1016/j.transproceed.2020.02.130 　

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Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.
Characteristics and predictive value for graft fibrosis of the complement-binding capacity of donor-specific human leukocyte antigen antibodies after pediatric liver transplantation. International-journal Peer-reviewed

Kazuaki Tokodai, Shigehito Miyagi, Wataru Nakanishi, Ryuichi Nishimura, Atsushi Fujio, Masafumi Goto, Michiaki Unno, Takashi Kamei

Pediatric transplantation　24　(1)　e13648　2020/02

DOI： 10.1111/petr.13648 　

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BACKGROUND: Donor-specific HLA antibodies (DSAs) have detrimental effects on short- and long-term outcomes after organ transplantation. Despite evidence that the complement-binding capacity of DSAs has predictive power in kidney transplantation, its clinical impact during long-term follow-up after LT remains unclear. In this study, we assessed the complement-binding capacities of DSAs and their association with histological findings. METHODS: In total, 72 patients who underwent pediatric LT at our institution between July 1991 and October 2013 were retrospectively reviewed. A subgroup analysis of histological findings was performed for 37 subjects who underwent liver graft biopsy. Patients were divided into two groups based on the degree of graft fibrosis, and clinical characteristics were assessed. RESULTS: All anti-class I DSAs were C1q-negative. Anti-DR and anti-DQ DSAs were identified in 34% and 41% of patients, respectively; however, only three of 25 patients with anti-DR DSAs exhibited a positive C1q-binding assay, whereas, 25 of 29 anti-DQ DSAs showed C1q-binding capacity. MFI values for DSA were significantly higher for patients with C1q-binding capacity than for those without (P < .0001). Complement-binding anti-DR DSA was relatively rare in both groups. Regarding anti-DQ DSA, there were no differences between fibrosis and non-fibrosis groups, irrespective of complement-binding capacity. CONCLUSIONS: The association between anti-DR DSA and liver fibrosis, which was supported in this cohort, was not strengthened but rather impaired when accounting for complement-binding capacity due to low positive detection. Further studies of the association between complement-binding anti-DQ DSA and histological findings in LT are needed.
Effects of a new perioperative enhanced recovery after surgery protocol in hepatectomy for hepatocellular carcinoma. Peer-reviewed

Atsushi Fujio, Shigehito Miyagi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Kazuhiro Mitsui, Michiaki Unno, Takashi Kamei

Surgery today　50　(6)　615-622　2019/12/03

DOI： 10.1007/s00595-019-01930-6 　

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PURPOSE: Enhanced recovery after surgery (ERAS) protocols are becoming the standard of care in many surgical procedures, although data on their use following hepatectomy for hepatocellular carcinoma (HCC) are scarce. This study aimed to evaluate the effects of a new ERAS pathway in terms of the patient nutrition status after hepatectomy for HCC. METHODS: This is a retrospective analysis of 97 consecutive patients treated with open or laparoscopic hepatectomy for HCC between January 2011 and August 2014. We compared the perioperative outcomes between patients whose treatment incorporated the ERAS pathway and control patients. The nutritional status was evaluated using the controlling nutritional status score. RESULTS: The length of hospital stay (LOS) after both open and laparoscopic hepatectomy was shorter for the ERAS group than the control group. The days of ambulation and cessation of intravenous infusion were earlier and the postoperative nutrition status was statistically better in the ERAS group than in the control group. A multivariate analysis showed that being in the non-ERAS group was a risk factor of delayed discharge. There were no marked differences in the rate of severe complications between the two groups. CONCLUSIONS: The ERAS pathway seems feasible and safe and results in a faster recovery, reduced LOS, improved nutrition status, and fewer severe complications.
小児肝移植症例における抗ドナーHLA抗体とグラフト線維化の関連

柿崎裕太, 戸子台和哲, 福岡健吾, 佐々木健吾, 藤尾淳, 西村隆一, 中西渉, 宮城重人

日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019/12
Publisher: (一社)日本小児栄養消化器肝臓学会
ISSN： 1346-9037
東北大学病院における小児肝移植の現状と今後の課題

佐々木健吾, 宮城重人, 笹嶋秀憲, 柿崎裕太, 福岡健吾, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 亀井尚, 海野倫明

日本小児栄養消化器肝臓学会雑誌　33　(2)　141-141　2019/12
Publisher: (一社)日本小児栄養消化器肝臓学会
ISSN： 1346-9037
F3-4肝線維化に対する腹腔鏡下肝切除の安全性について

宇根範和, 藤尾淳, 高舘達之, 石田晶玄, 戸子台和哲, 森川孝則, 宮城重人, 内藤剛, 海野倫明, 亀井尚

日本内視鏡外科学会雑誌　24　(7)　SF011-3　2019/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
高度肝硬変を有する肝細胞癌に対する腹腔鏡下肝切除の検討

藤尾淳, 宮城重人, 宇根範和, 中西渉, 高舘達之, 戸子台和哲, 石田晶玄, 森川孝則, 内藤剛, 海野倫明, 亀井尚

日本内視鏡外科学会雑誌　24　(7)　SF011-7　2019/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
F3-4肝線維化に対する腹腔鏡下肝切除の安全性について Peer-reviewed

宇根範和, 藤尾淳, 高舘達之, 石田晶玄, 戸子台和哲, 森川孝則, 宮城重人, 内藤剛, 海野倫明, 亀井尚

日本内視鏡外科学会雑誌　24　(7)　SF011-3　2019/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
高度肝硬変を有する肝細胞癌に対する腹腔鏡下肝切除の検討 Peer-reviewed

藤尾淳, 宮城重人, 宇根範和, 中西渉, 高舘達之, 戸子台和哲, 石田晶玄, 森川孝則, 内藤剛, 海野倫明, 亀井尚

日本内視鏡外科学会雑誌　24　(7)　SF011-7　2019/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
若い力が切り拓く今後の細胞移植医療羊膜由来幹細胞を用いた低侵襲細胞移植療法の確立

戸子台和哲, 伊藤貴子, 沖田ひとみ, 齋藤昌利, 星合哲郎, 山田修平, 宮城重人, 三木敏生, 海野倫明, 亀井尚, 後藤昌史

Organ Biology　26　(3)　59-59　2019/10
Publisher: (一社)日本臓器保存生物医学会
ISSN： 1340-5152

eISSN： 2188-0204
臨床外科医ができる動物移植モデルを使った基礎研究

山田修平, 柿崎裕太, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　74回　RS36-6　2019/07
Publisher: (一社)日本消化器外科学会
膵腎同時移植後患者の就労支援におけるレシピエント移植コーディネーターの役割について

佐藤則子, 山内悦子, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 後藤昌史

宮城県糖尿病看護研究会　15回　6-6　2019/06
Publisher: 宮城県糖尿病看護研究会
ISSN： 2187-2511
経口避妊薬内服中の若年女性に発生し増大傾向を示した肝focal nodular hyperplasiaの一例

宮崎勇希, 原康之, 宮城重人, 中西史, 戸子台和哲, 中西渉, 西村隆一, 藤島史喜, 海野倫明, 亀井尚

肝臓　60　(4)　127-134　2019/04
Publisher: (一社)日本肝臓学会
ISSN： 0451-4203

eISSN： 1881-3593
A case of progressive focal nodular hyperplasia developed in a young patient taking oral contraceptives

Yuki Miyazaki, Yasuyuki Hara, Shigehito Miyagi, Chikashi Nakanishi, Kazuaki Tokodai, Wataru Nakanishi, Ryuichi Nishimura, Fumiyoshi Fujishima, Michiaki Unno, Takashi Kamei

Acta Hepatologica Japonica　60　(4)　127-134　2019
Publisher: Japan Society of Hepatology
DOI： 10.2957/kanzo.60.127 　

ISSN： 1881-3593 0451-4203
Pediatric Living-Donor Liver Transplant Recipients without Transition After Reaching Adulthood. International-journal Peer-reviewed

Nakanishi C, Miyagi S, Tokodai K, Nakanishi W, Nishimura R, Goto M, Unno M, Kamei T

Annals of transplantation　24　18-24　2019/01

DOI： 10.12659/AOT.911544 　

ISSN： 1425-9524

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BACKGROUND Transition to adult care can trigger certain problems for pediatric liver transplant recipients. At our institution, the same transplant team performs both adult and pediatric liver transplantation and post-transplant care; thus, pediatric liver transplant recipients do not have to be transferred. However, it is unclear whether this system affects the recipient's outcome during the transition period. Therefore, we retrospectively assessed pediatric liver transplant recipients who reached adulthood at our institution. MATERIAL AND METHODS This was a single-center, retrospective study involving consecutive pediatric living-donor liver transplant recipients who reached the age of 18 by October 2017. A total of 36 recipients, 20 females and 16 males, were included in the study. RESULTS The 5- and 10-year patient survival after reaching the age of 18 was 100% and 93%, respectively. All of the 3 patients who died had been suffering from secondary biliary cirrhosis due to biliary stricture. In 5 patients (13.9%), biliary stricture became symptomatic or recurred after reaching the age of 18 years. Late-onset acute rejection and chronic rejection developed in 2 (5.6%) and 4 patients (11.1%), respectively. Only 4 (11.1%) patients were obviously noncompliant. We found no significant association between compliance and rejection or survival. Among the patients who are 18 years old and older, 5 (13.9%) had a psychiatric diagnosis. CONCLUSIONS Pediatric liver transplant recipients who underwent transplant surgery and received post-transplant care at our institution have good long-term outcomes. This suggests that having the same team perform both adult and pediatric transplantation and post-transplant care is beneficial for young adult recipients.
主に部分切除術・外側区域切除術を対象とした、腹腔鏡下肝切除術の周術期成績の検討

石田晶玄, 森川孝則, 高舘達之, 畠達夫, 伊関雅裕, 三浦孝之, 戸子台和哲, 青木豪, 中西史, 中川圭, 林洋毅, 宮城重人, 亀井尚, 内藤剛, 海野倫明

日本内視鏡外科学会雑誌　23　(7)　OS185-3　2018/12
Publisher: (一社)日本内視鏡外科学会
ISSN： 1344-6703

eISSN： 2186-6643
肝Reactive lymphoid hyperplasia3例の臨床病理組織学的検討

熊田博之, 松村宗幸, 清水健司, 中西渉, 戸子台和哲, 中西史, 宮城重人, 海野倫明, 亀井尚

日本消化器外科学会雑誌　51　(Suppl.2)　182-182　2018/11
Publisher: (一社)日本消化器外科学会
ISSN： 0386-9768

eISSN： 1348-9372
生体部分肝移植ドナー手術における低侵襲化の試み上腹部正中切開での右葉グラフト摘出

福岡健吾, 宮城重人, 中西史, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 熊田博之, 海野倫明

肝臓　59　(Suppl.3)　A926-A926　2018/11
Publisher: (一社)日本肝臓学会
ISSN： 0451-4203

eISSN： 1881-3593
Arterial Complication After Simultaneous Pancreas-Kidney Transplantation From an Abdominal Aortic Aneurysm Donor: A Case Report

K. Shimizu, S. Miyagi, K. Maida, W. Nakanishi, Y. Hara, K. Tokodai, C. Nakanishi, Y. Umeda, S. Satomi, M. Goto, M. Unno, T. Kamei

Transplantation Proceedings　50　2891-2894　2018/11/01

DOI： 10.1016/j.transproceed.2018.02.188 　

ISSN： 0041-1345
Correlation Between Splenectomy and Portal Vein Complications in Living Donor Liver Transplantation

S. Miyagi, C. Nakanishi, Y. Hara, W. Nakanishi, K. Tokodai, K. Shimizu, S. Uematsu, H. Kumata, Y. Kakizaki, M. Goto, T. Kamei, M. Unno, S. Satomi

Transplantation Proceedings　50　2611-2613　2018/11/01

DOI： 10.1016/j.transproceed.2018.03.104 　

ISSN： 0041-1345
Effect of Middle Hepatic Vein Tributaries Preserving Technique Until Just Before Graft Retrieval on Donors’ Surgical Outcomes in Living Donor Liver Transplantation

K. Miyazawa, S. Miyagi, C. Nakanishi, Y. Hara, K. Tokodai, K. Tokodai, W. Nakanishi, S. Uematsu, K. Shimizu, M. Goto, T. Kamei, M. Unno

Transplantation Proceedings　50　(9)　2636-2639　2018/11/01
Publisher: Elsevier BV
DOI： 10.1016/j.transproceed.2018.03.092 　

ISSN： 0041-1345
抗ドナーHLA抗体陽性の肝移植の短期・長期成績と問題点肝移植後長期経過症例における抗ドナーHLA抗体陽性の意義

戸子台和哲, 宮城重人, 中西史, 中西渉, 西村隆一, 清水健司, 福岡健吾, 熊田博之, 後藤昌史, 亀井尚, 海野倫明

移植　53　(総会臨時)　256-256　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
脳死肝摘出オールジャパン体制は是か否か肝膵腎移植を同チームで施行する立場から

宮城重人, 中西史, 戸子台和哲, 原康之, 中西渉, 西村隆一, 清水健司, 熊田博之, 福岡健吾, 後藤昌史, 亀井尚, 海野倫明

移植　53　(総会臨時)　261-261　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
小児移植後長期経過例の諸問題小児生体肝移植後成人移行症例の検討

中西史, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 後藤昌史, 海野倫明, 亀井尚

移植　53　(総会臨時)　286-286　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
当施設における生体肝移植ドナーの術後長期フォロー

西村隆一, 宮城重人, 中西史, 戸子台和哲, 中西渉, 清水健司, 福岡健吾, 熊田博之, 齋藤尚子, 後藤昌史, 亀井尚, 海野倫明

移植　53　(総会臨時)　405-405　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
腎グラフトに生じた尿管癌に対して移植腎摘出した一例

中西渉, 宮城重人, 中西史, 戸子台和哲, 西村隆一, 清水健司, 福岡健吾, 熊田博之, 海野倫明, 後藤昌史, 亀井尚

移植　53　(総会臨時)　414-414　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
抗ドナー血液型抗体価4096倍のABO血液型不適合生体肝移植を施行し良好な経過を得た1例

齋藤純健, 宮城重人, 中西史, 戸子台和哲, 中西渉, 西村隆一, 清水健司, 福岡健吾, 熊田博之, 松村宗幸, 後藤昌史, 亀井尚, 海野倫明

移植　53　(総会臨時)　449-449　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵腎同時移植後合併症と対策

宮城重人, 中西史, 戸子台和哲, 中西渉, 西村隆一, 亀井尚, 海野倫明, 後藤昌史

移植　53　(総会臨時)　518-518　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
本邦の膵島移植の今後の展開東北大学が目指す膵島移植の次の展開

後藤昌史, 稲垣明子, 山形洋平, 村山和隆, 渡邉君子, 前田浩, 猪村武弘, 五十嵐康宏, 植松智海, 宮崎勇希, 水井崇浩, Fathi Ibrahim, 戸子台和哲, 宮城重人, 藤盛啓成, 亀井尚, 海野倫明

移植　53　(総会臨時)　275-275　2018/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
The Risk Factors for Portal Vein Thrombosis After Living Donor Liver Transplantation in Adults Peer-reviewed

Miyagi Shigehito, Nakanishi Chikashi, Hara Yasuyuki, Tokodai Kazuaki, Nakanishi Wataru, Nishimura Ryuichi, Shimizu Kenji, Uematsu Satomi, Kumata Hiroyuki, Kakizaki Yuta, Matsumura Muneyuki, Unno Michiaki, Satomi Susumu, Kamei Takashi, Goto Masafumi

TRANSPLANTATION　102　S885　2018/07

DOI： 10.1097/01.tp.0000543975.03568.bd 　

ISSN： 0041-1337
Effects of Subnormothermic Perfusion Before Transplantation for Liver Grafts from Donation After Cardiac Death: A Simplified Dripping Perfusion Method in Pigs Peer-reviewed

Y. Kakizaki, S. Miyagi, K. Shimizu, H. Kumata, M. Matsumura, Y. Miyazaki, K. Fukuoka, S. S. Uematsu, K. Tokodai, Y. Hara, C. Nakanishi, M. Unno, T. Kamei, M. Goto

Transplantation Proceedings　50　(5)　1538-1543　2018/06/01
Publisher: Elsevier USA
DOI： 10.1016/j.transproceed.2018.02.061 　

ISSN： 1873-2623 0041-1345
術後合併症予防・早期回復のための周術期管理の工夫当科におけるEnhanced Recovery After Surgeryの原発性肝癌に対する肝切除における効果についての検討

中西渉, 宮城重人, 中西史, 戸子台和哲, 原康之, 宮澤恒持, 清水健司, 植松智海, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　118回　394-394　2018/04
Publisher: (一社)日本外科学会
小児肝移植後ドナー特異的抗HLA抗体と肝線維化の関連

戸子台和哲, 宮城重人, 中西史, 原康之, 中西渉, 宮澤恒持, 植松智海, 清水健司, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　118回　1076-1076　2018/04
Publisher: (一社)日本外科学会
膵頭十二指腸切除における動脈合併切除再建の安全性と当科における工夫

宮城重人, 中西史, 原康之, 中西渉, 戸子台和哲, 宮澤恒持, 清水健司, 植松智海, 森川孝則, 元井冬彦, 石田孝宣, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　118回　1367-1367　2018/04
Publisher: (一社)日本外科学会
Arterial and biliary complications after living donor liver transplantation: a single-center retrospective study and literature review Peer-reviewed

Shigehito Miyagi, Yuta Kakizaki, Kenji Shimizu, Koji Miyazawa, Wataru Nakanishi, Yasuyuki Hara, Kazuaki Tokodai, Chikashi Nakanishi, Takashi Kamei, Noriaki Ohuchi, Susumu Satomi

Surgery Today　48　(2)　131-139　2018/02/01
Publisher: Springer Tokyo
DOI： 10.1007/s00595-017-1515-9 　

ISSN： 1436-2813 0941-1291
The utility of superb microvascular imaging for monitoring low-velocity venous flow following pancreas transplantation: report of a case Peer-reviewed

Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Koji Miyazawa, Kenji Shimizu, Masafumi Goto, Takashi Kamei, Michiaki Unno

Journal of Medical Ultrasonics　45　(1)　171-174　2018/01/01
Publisher: Springer Tokyo
DOI： 10.1007/s10396-017-0795-4 　

ISSN： 1613-2254 1346-4523
A Case of Successful Simultaneous Pancreas-Kidney Transplantation Using the Injured Pancreas Graft Invited Peer-reviewed

S. Miyagi, K. Shimizu, K. Miyazawa, W. Nakanishi, Y. Hara, K. Tokodai, C. Nakanishi, S. Satomi, M. Goto, M. Unno, T. Kamei

TRANSPLANTATION PROCEEDINGS　49　(10)　2315-2317　2017/12

DOI： 10.1016/j.transproceed.2017.10.017 　

ISSN： 0041-1345

eISSN： 1873-2623
The extra-anatomical jump graft reconstruction of the right hepatic artery after resection of a biliary tract malignancy with a common hepatic artery aneurysm: a case report. International-journal Peer-reviewed

Kakizaki Y, Miyagi S, Hara Y, Fujio A, Miyazawa K, Maida K, Kashiwadate T, Tokodai K, Nakanishi C, Kamei T, Unno M

Clinical case reports　5　(11)　1841-1846　2017/11

DOI： 10.1002/ccr3.1200 　

More details Close

Performing resection of a biliary tract malignancy with a hepatic artery aneurysm is very challenging. Resection of the extrahepatic bile duct and extra-anatomical reconstruction can be successfully performed using free radial artery autografts from the aorta to the right hepatic artery. Hepatic artery thrombosis can be prevented with intimal preservation.
肝切除におけるEnhanced Recovery After Surgery(ERAS)の有効性についての介入研究

中西渉, 宮城重人, 中西史, 戸子台和哲, 原康之, 宮澤恒持, 清水健司, 海野倫明, 亀井尚

日本消化器外科学会雑誌　50　(Suppl.2)　508-508　2017/10
Publisher: (一社)日本消化器外科学会
ISSN： 0386-9768

eISSN： 1348-9372
Limited utility of blood cultures in the management of febrile outpatient kidney transplant recipients Peer-reviewed

Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki Kawagishi, Noriaki Ohuchi

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION　50　(5)　634-639　2017/10

DOI： 10.1016/j.jmii.2015.11.001 　

ISSN： 1684-1182

eISSN： 1995-9133
Renoportal Anastomosis in Left Lateral Lobe Living Donor Liver Transplantation: A Pediatric Case Peer-reviewed

Hiroyuki Ogasawara, Chikashi Nakanishi, Shigehito Miyagi, Kazuaki Tokodai, Yasuyuki Hara, Wataru Nakanishi, Koji Miyazawa, Kenji Shimizu, Hiroyuki Kumata, Hitoshi Goto, Masafumi Goto, Michiaki Unno, Takashi Kamei

Case Reports in Gastroenterology　11　(3)　584-592　2017/09/06
Publisher: S. Karger AG
DOI： 10.1159/000481160 　

ISSN： 1662-0631
小児移植におけるtransitional(移行期)ケアのあり方小児肝移植後成人移行症例における精神的問題を含めた諸問題

中西史, 宮城重人, 戸子台和哲, 原康之, 中西渉, 齋藤尚子, 後藤昌史, 海野倫明, 亀井尚

移植　52　(総会臨時)　267-267　2017/08
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵臓移植:マージナルドナーの適応と限界当院におけるマージナルドナー膵腎移植の現状

宮城重人, 中西史, 原康之, 戸子台和哲, 中西渉, 宮澤恒持, 清水健司, 植松智海, 海野倫明, 亀井尚

移植　52　(総会臨時)　293-293　2017/08
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
当科肝移植患者におけるPTLDの検討

宮城重人, 中西史, 原康之, 戸子台和哲, 中西渉, 宮澤恒持, 清水健司, 植松智海, 後藤昌史, 海野倫明, 亀井尚

移植　52　(総会臨時)　352-352　2017/08
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
生体肝移植後腎機能と長期予後ついての検討

中西史, 宮城重人, 戸子台和哲, 原康之, 中西渉, 宮澤恒持, 清水健司, 植松智海, 後藤昌史, 海野倫明, 亀井尚

移植　52　(総会臨時)　514-514　2017/08
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
膵島移植:今後の方向性はいかに? 免疫抑制剤不要の膵島移植実現へ向けて

後藤昌史, 稲垣明子, 猪村武弘, 五十嵐康宏, Fathi Ibrahim, 戸子台和哲, 宮城重人, 里見進

移植　52　(総会臨時)　306-306　2017/08
Publisher: (一社)日本移植学会
ISSN： 0578-7947

eISSN： 2188-0034
Splenectomy for Severe Intestinal Bleeding Caused by Portal Hypertensive Enteropathy After Pediatric Living-Donor Liver Transplantation: A Report of Three Cases Invited Peer-reviewed

K. Tokodai, N. Kawagishi, S. Miyagi, C. Nakanishi, Y. Hara, W. Nakanishi, T. Kennel, N. Ohuchi

TRANSPLANTATION PROCEEDINGS　49　(5)　1129-1132　2017/06

DOI： 10.1016/j.transproceed.2017.03.029 　

ISSN： 0041-1345

eISSN： 1873-2623
Effect of Recipient Age at Liver Transplantation on Prevalence of Post-Transplant Donor-Specific HLA Antibody Peer-reviewed

Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Michiaki Unno, Takashi Kamei

ANNALS OF TRANSPLANTATION　22　333-337　2017/06

DOI： 10.12659/AOT.903926 　

ISSN： 1425-9524
Delayed perforation occurring on the 24th day after endoscopic submucosal dissection for early gastric cancer Peer-reviewed

Satoru Homma, Kazuaki Tokodai, Minami Watanabe, Kai Takaya, Eiji Hashizume

Clinical Journal of Gastroenterology　10　(2)　124-127　2017/04/01
Publisher: Springer Tokyo
DOI： 10.1007/s12328-016-0709-9 　

ISSN： 1865-7265 1865-7257
Hassab's operation for Joubert syndrome with congenital hepatic fibrosis: A case report Peer-reviewed

Koji Miyazawa, Yasuyuki Hara, Kenji Shimizu, Wataru Nakanishi, Kazuaki Tokodai, Chikashi Nakanishi, Shigehito Miyagi, Naoki Kawagishi, Noriaki Ohuchi

International Journal of Surgery Case Reports　34　134-138　2017
Publisher: Elsevier Ltd
DOI： 10.1016/j.ijscr.2017.03.036 　

ISSN： 2210-2612
Spontaneous resolution of de novo hepatitis B after living donor liver transplantation with hepatitis B core antibody positive graft: a case report. International-journal Peer-reviewed

Hara Y, Tokodai K, Nakanishi C, Miyagi S, Kawagishi N

Surgical case reports　2　(1)　118-118　2016/12

DOI： 10.1186/s40792-016-0246-2 　

ISSN： 2198-7793

More details Close

BACKGROUND: Hepatitis B core antibody (HBcAb)-positive graft is reported to cause de novo hepatitis B after liver transplantation with a probability of 38-100 % without prophylaxis. Hepatitis B surface antigen loss is reported to be achieved with a probability of only 3-8 % in the patients treated by antiviral agents. We present an extremely rare case of spontaneous resolution of de novo hepatitis B after living donor liver transplantation (LDLT) with HBcAb-positive graft. CASE PRESENTATION: An 8-year-old female patient underwent LDLT for end-stage biliary atresia using an HBcAb-positive left lobe graft. After transplantation, she did not receive any prophylactic agents for hepatitis B. Two years after LDLT, she was diagnosed with chronic hepatitis B. Six years after LDLT, liver fibrosis and hepatitis activity were advanced and lamivudine was started. Two years after lamivudine administration, emergence of a lamivudine-resistant YMDD mutant was detected and adefovir dipivoxil was combined with lamivudine. Hepatitis B virus deoxyribonucleic acid (HBV-DNA) became undetectable soon after the addition of adefovir dipivoxil. Twelve years after transplantation, acute rejection occurred and steroid pulse therapy was performed, but hepatitis B did not become severe and HBV-DNA continued to be undetectable. Fifteen years after LDLT, she voluntarily discontinued medication of all drugs, including immunosuppressive agents and antiviral drugs for 1 year because of mental instability. After an interval of 1 year, liver function was normal and her serological HBV status was as follows: HBsAg(-), HBsAb(+), HBeAb(-), HBeAb(+), HBcAb(+) and HBV-DNA(-). From these results, we diagnosed her condition as spontaneous clearance of de novo hepatitis B. The patient is free of antiviral therapies and continues to take a low dose of immunosuppressive drugs and is leading a normal life. CONCLUSIONS: In this case, HBsAg loss is finally achieved but we need to follow carefully for HBV reactivation with the fibrosis of the graft in mind.
Poor Long-Term Outcomes of Adult Liver Transplantation Involving Elderly Living Donors Invited Peer-reviewed

K. Tokodai, N. Kawagishi, S. Miyagi, C. Nakanishi, Y. Hara, A. Fujio, T. Kashiwadate, K. Maida, H. Goto, T. Kamei, N. Ohuchi

TRANSPLANTATION PROCEEDINGS　48　(4)　1130-1133　2016/05

DOI： 10.1016/j.transproceed.2016.01.016 　

ISSN： 0041-1345

eISSN： 1873-2623
The Significance of Screening for HLA Antibodies in the Long-Term Follow-up of Pediatric Liver Transplant Recipients Invited Peer-reviewed

K. Tokodai, N. Kawagishi, S. Miyagi, C. Nakanishi, Y. Hara, A. Fujio, T. Kashiwadate, K. Maida, H. Goto, T. Kamei, N. Ohuchi

TRANSPLANTATION PROCEEDINGS　48　(4)　1139-1141　2016/05

DOI： 10.1016/j.transproceed.2015.12.081 　

ISSN： 0041-1345

eISSN： 1873-2623
Relationship Between Bile Duct Reconstruction and Complications in Living Donor Liver Transplantation Invited Peer-reviewed

S. Miyagi, N. Kawagishi, T. Kashiwadate, A. Fujio, K. Tokodai, Y. Hara, C. Nakanishi, T. Kamei, N. Ohuchi, S. Satomi

TRANSPLANTATION PROCEEDINGS　48　(4)　1166-1169　2016/05

DOI： 10.1016/j.transproceed.2015.10.073 　

ISSN： 0041-1345

eISSN： 1873-2623
Short Oxygenated Warm Perfusion With Prostaglandin E1 Administration Before Cold Preservation as a Novel Resuscitation Method for Liver Grafts From Donors After Cardiac Death in a Rat In Vivo Model Peer-reviewed

Kai Maida, Yorihiro Akamatsu, Yasuyuki Hara, Kazuaki Tokodai, Shigehito Miyagi, Toshiaki Kashiwadate, Koji Miyazawa, Naoki Kawagishi, Noriaki Ohuchi

TRANSPLANTATION　100　(5)　1052-1058　2016/05

DOI： 10.1097/TP.0000000000001127 　

ISSN： 0041-1337

eISSN： 1534-6080
Successful Case of Somatostatin Analog Stopping Gastrointestinal Bleeding, One of the Most Frequent Complications After Simultaneous Pancreas-kidney Transplantation: A Case Report Invited Peer-reviewed

S. Miyagi, A. Fujio, K. Tokodai, Y. Hara, C. Nakanishi, H. Goto, T. Kamei, N. Kawagishi, N. Ohuchi, S. Satomi

TRANSPLANTATION PROCEEDINGS　48　(3)　985-987　2016/04

DOI： 10.1016/j.transproceed.2015.10.072 　

ISSN： 0041-1345

eISSN： 1873-2623
Indications and outcomes of an endoscopic approach under laparotomy for the treatment of bilioenteric anastomotic strictures Peer-reviewed

Kazuaki Tokodai, Naoki Kawagishi, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Atsushi Fujio, Toshiaki Kashiwadate, Atsushi Kanno, Hitoshi Goto, Takashi Kamei, Noriaki Ohuchi

PEDIATRIC TRANSPLANTATION　20　(2)　316-320　2016/03

DOI： 10.1111/petr.12655 　

ISSN： 1397-3142

eISSN： 1399-3046
Prevalence and risk factors of obesity, hypertension, dyslipidemia and diabetes mellitus before and after adult living donor liver transplantation Peer-reviewed

Yasuyuki Hara, Naoki Kawagishi, Wataru Nakanishi, Kazuaki Tokodai, Chikashi Nakanishi, Shigehito Miyagi, Noriaki Ohuchi

HEPATOLOGY RESEARCH　45　(7)　764-770　2015/07

DOI： 10.1111/hepr.12418 　

ISSN： 1386-6346

eISSN： 1872-034X
Right versus left retroperitoneoscopic living-donor nephrectomy Peer-reviewed

Toshiaki Kashiwadate, Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Tetsuro Takayama, Atsushi Nakamura, Takuya Jimbo, Yasuyuki Hara, Naoki Kawagishi, Noriaki Ohuchi

INTERNATIONAL UROLOGY AND NEPHROLOGY　47　(7)　1117-1121　2015/07

DOI： 10.1007/s11255-015-1014-0 　

ISSN： 0301-1623

eISSN： 1573-2584
Long-Term Survival with Growth Hormone Replacement after Liver Transplantation of Pediatric Nonalcoholic Steatohepatitis Complicating Acquired Hypopituitarism Peer-reviewed

Atsushi Fujio, Naoki Kawagishi, Taketora Echizenya, Kazuaki Tokodai, Chikashi Nakanishi, Shigehito Miyagi, Kazushige Sato, Keisei Fujimori, Noriaki Ohuchi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　235　(1)　61-67　2015/01

DOI： 10.1620/tjem.235.61 　

ISSN： 0040-8727

eISSN： 1349-3329
Insulin Resistance as a Risk Factor for New-Onset Diabetes After Kidney Transplantation Invited Peer-reviewed

K. Tokodai, N. Amada, I. Haga, T. Takayama, A. Nakamura, T. Kashiwadate

TRANSPLANTATION PROCEEDINGS　46　(2)　537-539　2014/03

DOI： 10.1016/j.transproceed.2013.10.060 　

ISSN： 0041-1345

eISSN： 1873-2623
Effects of Elevated Tacrolimus Trough Levels in Association With Infectious Enteritis on Graft Function in Renal Transplant Recipients Invited Peer-reviewed

A. Nakamura, N. Amada, I. Naga, K. Tokodai, T. Kashiwadate

TRANSPLANTATION PROCEEDINGS　46　(2)　592-594　2014/03

DOI： 10.1016/j.transproceed.2013.11.040 　

ISSN： 0041-1345

eISSN： 1873-2623
Medication Compliance in Renal Transplant Patients During the Great East Japan Earthquake Invited Peer-reviewed

M. Kadowaki, M. Saito, N. Amada, I. Haga, A. Nakamura, K. Tokodai

TRANSPLANTATION PROCEEDINGS　46　(2)　610-612　2014/03

DOI： 10.1016/j.transproceed.2013.11.039 　

ISSN： 0041-1345

eISSN： 1873-2623
Pretransplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin Peer-reviewed

Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki Kawagishi, Noriaki Ohuchi

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY　2014　436725　2014

DOI： 10.1155/2014/436725 　

ISSN： 1687-8337

eISSN： 1687-8345
Retroperitoneoscopic Living Donor Nephrectomy: Short Learning Curve and Our Original Hybrid Technique Peer-reviewed

Kazuaki Tokodai, Tetsuro Takayama, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate

UROLOGY　82　(5)　1054-1058　2013/11

DOI： 10.1016/j.urology.2013.08.003 　

ISSN： 0090-4295

eISSN： 1527-9995
Body Fat Percentage as a Marker of New-Onset Diabetes Mellitus After Kidney Transplantation Invited Peer-reviewed

K. Tokodai, N. Amada, H. Kikuchi, I. Haga, T. Takayama, A. Nakamura

TRANSPLANTATION PROCEEDINGS　45　(4)　1544-1547　2013/05

DOI： 10.1016/j.transproceed.2012.12.009 　

ISSN： 0041-1345

eISSN： 1873-2623
Posttransplant increase of body mass index is associated with new-onset diabetes mellitus after kidney transplantation Peer-reviewed

Kazuaki Tokodai, Noritoshi Amada, Hiroyuki Kikuchi, Izumi Haga, Tetsuro Takayama, Atsushi Nakamura

Tohoku Journal of Experimental Medicine　229　(3)　227-232　2013
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.229.227 　

ISSN： 1349-3329 0040-8727
Intestinal obstruction caused by colonic metastasis from intrahepatic cholangiocarcinoma 6 years after removal of the primary tumor: report of a case Peer-reviewed

Kazuaki Tokodai, Naoki Kawagishi, Shigehito Miyagi, Ikuo Takeda, Kazushige Sato, Yorihiro Akamatsu, Satoshi Sekiguchi, Kazuyuki Ishida, Susumu Satomi

SURGERY TODAY　42　(8)　797-800　2012/08

DOI： 10.1007/s00595-012-0138-4 　

ISSN： 0941-1291
The Relationship Between Recurrences and Immunosuppression on Living Donor Liver Transplantation for Hepatocellular Carcinoma Invited Peer-reviewed

S. Miyagi, N. Kawagishi, S. Sekiguchi, Y. Akamatsu, K. Sato, I. Takeda, Y. Kobayashi, K. Tokodai, K. Fujimori, S. Satomi

TRANSPLANTATION PROCEEDINGS　44　(3)　797-801　2012/04

DOI： 10.1016/j.transproceed.2012.01.012 　

ISSN： 0041-1345
Outcomes of Renal Transplantation After End-Stage Renal Disease Due to Diabetic Nephropathy: A Single-Center Experience Invited Peer-reviewed

K. Tokodai, N. Amada, H. Kikuchi, I. Haga, T. Takayama, A. Nakamura

TRANSPLANTATION PROCEEDINGS　44　(1)　77-79　2012/01

DOI： 10.1016/j.transproceed.2011.11.047 　

ISSN： 0041-1345
Effect of Synthetic Protease Inhibitor Gabexate Mesilate on Attenuation of Coagulant Activity and Cytokine Release in a Rat Model of Islet Transplantation Peer-reviewed

K. Tokodai, M. Goto, A. Inagaki, T. Imura, S. Satomi

TRANSPLANTATION PROCEEDINGS　43　(9)　3176-3178　2011/11

DOI： 10.1016/j.transproceed.2011.10.035 　

ISSN： 0041-1345
Expression of Receptors for Anaphylatoxins C3a and C5a on Rat Islet Preparations Invited Peer-reviewed

K. Tokodai, M. Goto, A. Inagaki, T. Imura, W. Nakanishi, S. Satomi

TRANSPLANTATION PROCEEDINGS　43　(9)　3179-3180　2011/11

DOI： 10.1016/j.transproceed.2011.10.006 　

ISSN： 0041-1345
Rituximab Therapy and Reduction of Immunosuppression to Rescue Graft Function After Renal Posttransplantation Lymphoproliferative Disorder Found by Macrohematuria in a Pancreas and Kidney Transplant Recipient: A Case Report Invited Peer-reviewed

S. Miyagi, S. Sekiguchi, N. Kawagishi, Y. Akamatsu, K. Satoh, I. Takeda, D. Fukushima, Y. Kobayashi, K. Tokodai, K. Fujimori, S. Satomi

TRANSPLANTATION PROCEEDINGS　43　(9)　3299-3301　2011/11

DOI： 10.1016/j.transproceed.2011.10.002 　

ISSN： 0041-1345
Attenuation of cross-talk between the complement and coagulation cascades by C5a blockade improves early outcomes after intraportal islet transplantation Peer-reviewed

TOKODAI Kazuaki, GOTO Masafumi, INAGAKI Akiko, NAKANISHI Wataru, OGAWA Norihiko, SATOH Kazushige, KAWAGISHI Naoki, SEKIGUCHI Satoshi, NILSSON Bo, OKADA Noriko, OKADA Hidechika, SATOMI Susumu

46　(4 & 5)　343-352　2011

ISSN： 0578-7947
C5a-Inhibitory Peptide Combined with Gabexate Mesilate Prevents the Instant Blood-Mediated Inflammatory Reaction in a Rat Model of Islet Transplantation Peer-reviewed

K. Tokodai, M. Goto, A. Inagaki, W. Nakanishi, N. Okada, H. Okada, S. Satomi

TRANSPLANTATION PROCEEDINGS　42　(6)　2102-2103　2010/07

DOI： 10.1016/j.transproceed.2010.05.100 　

ISSN： 0041-1345
C5a Inhibitory Peptide Combined With Gabexate Mesilate Is a Clinically Available Candidate for Preventing the Instant Blood-Mediated Inflammatory Reaction Peer-reviewed

K. Tokodai, M. Goto, T. Imura, N. Ogawa, K. Fujimori, Y. Kurokawa, H. Okada, S. Satomi

TRANSPLANTATION PROCEEDINGS　41　(1)　67-68　2009/01

DOI： 10.1016/j.transproceed.2008.10.029 　

ISSN： 0041-1345
C5a inhibitory peptide AcPepA is a clinically available candidate for preventing rapid loss of intraportally transplanted islets Peer-reviewed

Kazuaki Tokodai, Masafumi Goto, Takehiro Imura, Yoshimochi Kurokawa, Noriko Okada, Hidechika Okada, Susumu Satomi

MOLECULAR IMMUNOLOGY　45　(16)　4151-4151　2008/10

DOI： 10.1016/j.molimm.2008.08.168 　

ISSN： 0161-5890

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Misc. 53

The impact of improving hypoxic conditions on graft viability in subcutaneous islet transplantation.

Hiroaki Mitsugashira, Takehiro Imura, Akiko Inagaki, Yukiko Endo Kumata, Takumi Katano, Kazuaki Tokodai, Kimiko Watanabe, Takashi Kamei, Michiaki Unno, Masafumi Goto

TRANSPLANTATION　108　(9)　432-432　2024/09

ISSN： 0041-1337

eISSN： 1534-6080
The impact of improving hypoxic conditions on graft viability in subcutaneous islet transplantation.

Hiroaki Mitsugashira, Takehiro Imura, Akiko Inagaki, Yukiko Endo Kumata, Takumi Katano, Kazuaki Tokodai, Kimiko Watanabe, Takashi Kamei, Michiaki Unno, Masafumi Goto

TRANSPLANTATION　108　(9S)　2024/09

DOI： 10.1097/01.tp.0001066872.73057.c5 　

ISSN： 0041-1337

eISSN： 1534-6080
膵島移植においてアロ免疫拒絶制御以外に別の膵島生着促進作用も併せ持つ新規免疫抑制薬の開発

鈴木翔輝, 猪村武弘, 稲垣明子, 前川正充, 奥平貴成, 片野匠, 公文代將希, 佐藤裕, 戸子台和哲, 海野倫明, 亀井尚, 渡邉君子, 後藤昌史

Organ Biology (Web)　31　(3)　2024

ISSN： 2188-0204
膵島移植に理想的な新規免疫抑制プロトコールの開発

鈴木翔輝, 猪村武弘, 前川正充, 稲垣明子, 眞屋梢, 後藤めぐみ, 遠藤有希子, 片野匠, 戸子台和哲, 戸子台和哲, 海野倫明, 亀井尚, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　51st　2024
不織布構造ゼラチン基材を用いた新規膵島移植法の構築

遠藤有希子, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　51st　2024
皮下膵島移植における低酸素環境改善が移植膵島グラフトに与える影響

三頭啓明, 猪村武弘, 稲垣明子, 鈴木翔輝, 遠藤有希子, 片野匠, 戸子台和哲, 渡邉君子, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

膵臓(Web)　39　(3)　2024

ISSN： 1881-2805
Development of a novel method for measuring tissue oxygen pressure to improve the hypoxic condition in subcutaneous islet transplantation

Hiroaki Mitsugashira, Takehiro Imura, Akiko Inagaki, Shoki Suzuki, Yukiko Endo, Takumi Katano, Ryusuke Saito, Kazuaki Tokodai, Kimiko Watanabe, Takashi Kamei, Michiaki Unno, Masafumi Goto

TRANSPLANTATION　107　(10)　3-4　2023/10

DOI： 10.1097/01.tp.0000993732.35468.fa 　

ISSN： 0041-1337

eISSN： 1534-6080
不織布構造ゼラチン基材と脂肪由来幹細胞の併用による皮下膵島移植成績の検討

齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 遠藤有希子, 三頭啓明, 金井哲史, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023
不織布構造ゼラチン基材の前留置期間が皮下膵島移植のグラフト生着へ及ぼす影響に関する検討

齊藤竜助, 稲垣明子, 中村保宏, 猪村武弘, 片野匠, 鈴木翔輝, 遠藤有希子, 三頭啓明, 金井哲史, 戸子台和哲, 亀井尚, 海野倫明, 渡邉君子, 田畑泰彦, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023
低酸素環境改善を目的とした新規組織内酸素濃度測定法の開発と皮下膵島移植への応用

三頭啓明, 猪村武弘, 稲垣明子, 鈴木翔輝, 遠藤有希子, 片野匠, 齋藤竜助, 戸子台和哲, 渡邉君子, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023
東北大学における膵島移植の保険診療実施体制の構築

沖田ひとみ, 伊藤貴子, 佐藤則子, 佐藤則子, 藤尾淳, 戸子台和哲, 戸子台和哲, 戸子台和哲, 岡田克典, 岡田克典, 岡田克典, 海野倫明, 亀井尚, 亀井尚, 後藤昌史, 後藤昌史, 後藤昌史, 後藤昌史

日本膵・膵島移植学会プログラム・抄録集　50th (CD-ROM)　2023
血液型不適合肝臓移植の現状と課題心停止ドナー肝グラフトの臓器再生の現状と展望

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 宮崎勇希, 笹嶋秀憲, 後藤昌史, 亀井尚, 海野倫明

移植　54　(総会臨時)　184-184　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947
肝移植後胆管空腸吻合部狭窄に対し、ブロッケンブロー針を用いて胆管空腸の瘻孔化に成功した一例

佐々木健吾, 宮城重人, 笹嶋秀憲, 宮崎勇希, 藤尾淳, 西村隆一, 中西渉, 戸子台和哲, 大田英揮, 高瀬圭, 亀井尚, 海野倫明

移植　54　(総会臨時)　200-200　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947
補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響

戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 宮崎勇希, 笹嶋秀憲, 後藤昌史, 海野倫明, 亀井尚

移植　54　(総会臨時)　226-226　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947
エコー上指摘された生体肝移植後早期門脈ガス像の臨床的意義

中西渉, 宮城重人, 戸子台和哲, 西村隆一, 藤尾淳, 佐々木健吾, 宮崎勇希, 笹嶋秀憲, 内藤剛, 海野倫明, 後藤昌史, 亀井尚

移植　54　(総会臨時)　290-290　2019/09
Publisher: (一社)日本移植学会
ISSN： 0578-7947
低侵襲細胞移植療法の確立を目的とした羊膜上皮細胞分離体制の構築

戸子台和哲, 伊藤貴子, 沖田ひとみ, 齋藤昌利, 星合哲郎, 山田修平, 宮城重人, 海野倫明, 亀井尚, 後藤昌史, 後藤昌史

日本組織移植学会雑誌　18　(1)　44　2019/07/05

ISSN： 1347-6491
高度心機能低下を有するWilson病患者に対し、肝移植後、大動脈内バルーンパンピングを使用し救命した一例

佐々木健吾, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　74回　P195-4　2019/07
Publisher: (一社)日本消化器外科学会
腎機能障害を有する患者の周術期管理 Chronic kidney diseaseを伴う肝細胞癌患者に対する肝切除術周術期合併症への影響

西村隆一, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 佐々木健吾, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　74回　WS16-7　2019/07
Publisher: (一社)日本消化器外科学会
小児生体肝移植術後の晩期門脈合併症に対する治療戦略

藤尾淳, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 佐々木健吾, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　74回　P198-6　2019/07
Publisher: (一社)日本消化器外科学会
胆道閉鎖症葛西術後キャリーオーバー症例を含む、複数開腹歴のある症例に対する肝移植

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 佐々木健吾, 柿崎裕太, 亀井尚, 海野倫明

日本消化器外科学会総会　74回　O22-2　2019/07
Publisher: (一社)日本消化器外科学会
臨床外科医ができる動物移植モデルを使った基礎研究

山田修平, 柿崎裕太, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 内藤剛, 海野倫明, 亀井尚

日本消化器外科学会総会　74回　RS36-6　2019/07
Publisher: (一社)日本消化器外科学会
多職種介入によるNSTの現状と問題点

中西渉, 宮城重人, 戸子台和哲, 西村隆一, 佐々木健吾, 福岡健吾, 熊田博之, 石田孝宣, 内藤剛, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　119回　PS-012　2019/04
Publisher: (一社)日本外科学会
当科における12歳未満の小児生体肝移植の成績について

藤尾淳, 宮城重人, 中西史, 戸子台和哲, 中西渉, 西村隆一, 佐々木健吾, 福岡健吾, 熊田博之, 内藤剛, 石田孝宣, 亀井尚, 海野倫明

日本外科学会定期学術集会抄録集　119回　PS-088　2019/04
Publisher: (一社)日本外科学会
肝・膵粘液性嚢胞腫瘍における卵巣様間質でのステロイドホルモン合成動態についての免疫組織化学的検討

熊田博之, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 福岡健吾, 内藤剛, 海野倫明, 亀井尚

日本外科学会定期学術集会(Web)　119回　PS-1　2019/04
Publisher: (一社)日本外科学会
進行肝門部胆管癌に対する動門脈合併切除の成績及び血管内皮保護を目的とした超音波モニタリング術後管理法の有用性

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 熊田博之, 佐々木健吾, 中川圭, 森川孝則, 元井冬彦, 内藤剛, 石田孝宣, 力山敏樹, 亀井尚, 海野倫明

日本外科学会定期学術集会(Web)　119回　SF-1:[P]　2019/04
Publisher: (一社)日本外科学会
甲状腺髄様癌が傍神経節腫に腫瘍内転移したMEN2Bの一例

菖野佳浩, 戸子台和哲, 西村隆一, 中西渉, 藤尾淳, 佐々木健吾, 福岡健吾, 柿崎裕太, 宮城重人, 亀井尚, 石田孝宣, 海野倫明, 山崎有人, 笹野公伸

日本内分泌学会雑誌　95　(1)　497-497　2019/04
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
慢性抗体関連型拒絶の病理像を呈しDPにのみDSAを認めた1例

福岡健吾, 戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 柿崎裕太, 海野倫明, 亀井尚

日本臨床腎移植学会プログラム・抄録集　52回　254-254　2019/02
Publisher: (一社)日本臨床腎移植学会
膵腎同時移植後の血管合併症と対策

宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 佐々木健吾, 福岡健吾, 柿崎裕太, 笹嶋秀憲, 亀井尚, 海野倫明, 後藤昌史, 後藤昌史

日本膵・膵島移植研究会プログラム・抄録集　46th　52　2019/02
膵腎同時移植後患者の就労支援におけるレシピエント移植コーディネーターの役割の検討

佐藤則子, 佐藤則子, 宮城重人, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 後藤昌史, 後藤昌史

日本膵・膵島移植研究会プログラム・抄録集　46th　59　2019/02
免疫抑制剤不要の次世代膵島移植実現へ向けた試み

後藤昌史, 後藤昌史, 稲垣明子, 猪村武弘, IBRAHIM Fathi, 水井崇浩, 金井哲史, 戸子台和哲, 宮城重人, 村山和隆, 亀井尚, 海野倫明

日本膵・膵島移植研究会プログラム・抄録集　46th　2019
生体肝移植におけるMELDを含む術前因子と予後の検討

中西史, 宮城重人, 戸子台和哲, 中西渉, 西村隆一, 藤尾淳, 後藤昌史, 内藤剛, 海野倫明, 石田孝宣, 亀井尚

日本外科学会定期学術集会(Web)　119th　ROMBUNNO.PS‐087‐2 (WEB ONLY)　2019
Chronic kidney diseaseを併せもつ肝細胞癌症例に対するanatomical resectionとnon‐anatomical resectionの比較検討

西村隆一, 宮城重人, 戸子台和哲, 中西渉, 藤尾淳, 福岡健吾, 内藤剛, 石田孝宣, 海野倫明, 亀井尚

日本外科学会定期学術集会(Web)　119th　ROMBUNNO.PS‐075‐4 (WEB ONLY)　2019
1型糖尿病根治のための当施設のストラテジー―膵臓移植短期合併症の克服と低侵襲細胞治療の成績向上―

戸子台和哲, 宮城重人, 中西渉, 西村隆一, 藤尾淳, 福岡健吾, 内藤剛, 石田孝宣, 後藤昌史, 海野倫明, 亀井尚

日本外科学会定期学術集会(Web)　119th　ROMBUNNO.SF‐054‐5 (WEB ONLY)　2019
小児肝移植後におけるドナー特異的抗HLA-Cw/DP抗体の意義

戸子台和哲, 宮城重人, 中西史, 原康之, 中西渉, 西村隆一, 清水健司, 後藤昌史, 海野倫明, 亀井尚

日本消化器外科学会総会　73回　953-953　2018/07
Publisher: (一社)日本消化器外科学会
Analysis of the Association of Posttransplant Donor-Specific HLA Antibody with Liver Fibrosis After Pediatric Liver Transplantation

Kazuaki Tokodai, Shigehito Miyagi, Chikashi Nakanishi, Yasuyuki Hara, Wataru Nakanishi, Ryuichi Nishimura, Koji Miyazawa, Satomi Uematsu, Kenji Shimizu, Keigo Murakami, Hironobu Sasano, Masafumi Goto, Michiaki Unno, Takashi Kamei

TRANSPLANTATION　102　S127-S127　2018/07

DOI： 10.1097/01.tp.0000542741.72759.61 　

ISSN： 0041-1337

eISSN： 1534-6080
肝管空腸吻合を伴う生体肝移植後の胆道狭窄危険因子、治療、長期追跡調査(Biliary stricture after living-donor liver transplantation with hepaticojejunostomy: risk factors, treatment and long-term follow up)

Nakanishi Chikashi, Miyagi Shigehito, Tokodai Kazuaki, Hara Yasuyuki, Nakanishi Wataru, Nishimura Ryuichi, Kamei Takashi, Unno Michiaki

日本肝胆膵外科学会・学術集会プログラム・抄録集　30回　447-447　2018/06
Publisher: (一社)日本肝胆膵外科学会
心停止下摘出肝グラフトに対する移植前室温酸素化灌流の臓器保存効果

柿崎裕太, 宮城重人, 清水健司, 熊田博之, 松村宗幸, 宮崎勇希, 福岡健吾, 植松智海, 原康之, 戸子台和哲, 中西史, 海野倫明, 亀井尚

日本外科学会定期学術集会抄録集　118回　1248-1248　2018/04
Publisher: (一社)日本外科学会
東北大学における次世代膵島移植確立へ向けた技術革新

後藤昌史, 後藤昌史, 稲垣明子, 山形洋平, 村山和隆, 渡邉君子, 前田浩, 猪村武弘, 五十嵐康宏, 植松智海, 宮崎勇希, 水井崇浩, 戸子台和哲, 宮城重人, 角昭一郎, 藤盛啓成, 大内憲明, 里見進

日本膵・膵島移植研究会プログラム・抄録集　44th　2017
膵臓移植後の静脈血流評価におけるSuperb microvascular imaging(SMI)の有用性

戸子台和哲, 清水健司, 米田海, 宮澤恒持, 中西渉, 原康之, 中西史, 宮城重人

日本膵・膵島移植研究会プログラム・抄録集　44th　2017
Short-Term Postoperative Course Affects the Outcome in Adult Living Donor Liver Transplantation

Kai Maida, Chikashi Nakanishi, Naoki Kawagishi, Shigehito Miyagi, Kazuaki Tokodai, Yasuyuki Hara, Toshiaki Kashiwadate, Kouji Miyazawa, Satoru Yoshida, Noriaki Ohuchi

TRANSPLANTATION　100　S150-S150　2016/05

ISSN： 0041-1337

eISSN： 1534-6080
新規膵島分離用酵素剤の臨床応用と今後の戦略

後藤昌史, 後藤昌史, 山形洋平, 山形洋平, 村山和隆, 渡邉君子, 前田浩, 前田浩, 猪村武弘, 稲垣明子, 五十嵐康宏, 宮城重人, 戸子台和哲, 田頭真実, 藤盛啓成, KORSGREN Olle, 大内憲明, 里見進

日本膵・膵島移植研究会プログラム・抄録集　42nd　2015
Long-Term Results On The Immunosuppression Withdrawal in Pediatric Recipients of Parental Living Donor Liver Transplants.

N. Kawagishi, K. Tokodai, I. Takeda, S. Miyagi, K. Satoh, N. Ohuchi

TRANSPLANTATION　98　713-713　2014/07

ISSN： 0041-1337

eISSN： 1534-6080
A Single Center Experience of Living Donor Liver Transplantation for Acute Liver Failure.

A. Fujio, I. Takeda, W. Nakanishi, R. Nishimura, Y. Miura, K. Tokodai, S. Miyagi, K. Sato, N. Kawagishi, K. Fujimori, N. Ohuchi

TRANSPLANTATION　98　784-784　2014/07

ISSN： 0041-1337

eISSN： 1534-6080
Right Versus Left Retroperitoneoscopic Living Donor Nephrectomy.

T. Kashiwadate, K. Tokodai, N. Amada, I. Haga, T. Takayama, A. Nakamura, T. Jimbo

TRANSPLANTATION　98　604-604　2014/07

ISSN： 0041-1337

eISSN： 1534-6080
Pre-Transplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin

K. Tokodai, N. Amada, I. Haga, A. Nakamura, T. Kashiwadate, N. Kawagishi, N. Ohuchi

TRANSPLANTATION　98　525-525　2014/07

ISSN： 0041-1337

eISSN： 1534-6080
Right Versus Left Retroperitoneoscopic Living Donor Nephrectomy.

T. Kashiwadate, K. Tokodai, N. Amada, I. Haga, T. Takayama, A. Nakamura, T. Jimbo

AMERICAN JOURNAL OF TRANSPLANTATION　14　604-604　2014/06

ISSN： 1600-6135

eISSN： 1600-6143
A Single Center Experience of Living Donor Liver Transplantation for Acute Liver Failure

A. Fujio, I. Takeda, W. Nakanishi, R. Nishimura, Y. Miura, K. Tokodai, S. Miyagi, K. Sato, N. Kawagishi, K. Fujimori, N. Ohuchi

AMERICAN JOURNAL OF TRANSPLANTATION　14　784-784　2014/06

ISSN： 1600-6135

eISSN： 1600-6143
Long-Term Results On The Immunosuppression Withdrawal in Pediatric Recipients of Parental Living Donor Liver Transplants.

N. Kawagishi, K. Tokodai, I. Takeda, S. Miyagi, K. Satoh, N. Ohuchi

AMERICAN JOURNAL OF TRANSPLANTATION　14　713-713　2014/06

ISSN： 1600-6135

eISSN： 1600-6143
Pre-Transplant HbA1c Is a Useful Predictor for the Development of New-Onset Diabetes in Renal Transplant Recipients Receiving No or Low-Dose Erythropoietin.

K. Tokodai, N. Amada, I. Haga, A. Nakamura, T. Kashiwadate, N. Kawagishi, N. Ohuchi

AMERICAN JOURNAL OF TRANSPLANTATION　14　525-525　2014/06

ISSN： 1600-6135

eISSN： 1600-6143
FIVE TIMED ORAL GLUCOSE TOLERANCE TEST AS A PREDICTOR OF NEW-ONSET DIABETES AFTER KIDNEY TRANSPLANTATION

Kazuaki Tokodai, Noritoshi Amada, Hiroyuki Kikuchi, Izumi Haga, Tetsuro Takayama, Atsushi Nakamura

TRANSPLANT INTERNATIONAL　26　236-236　2013/11

ISSN： 0934-0874

eISSN： 1432-2277
A Rare Case that Had Hepatic Artery Thrombosis and Suffered from East Japan Huge Earthquake after Living Donor Liver Transplantation - a Case Report

S. Miyagi, Y. Kobayashi, K. Tokodai, D. Fukushima, Takeda, I, K. Satoh, Y. Akamatsu, S. Sekiguchi, N. Kawagishi, S. Satomi

TRANSPLANTATION　94　(10)　398-398　2012/11

ISSN： 0041-1337

eISSN： 1534-6080
Increasing Rate of Body Fat Percentage as a New Risk Factor for New-Onset Diabetes Mellitus after Kidney Transplantation

K. Tokodai, N. Amada, H. Kikuchi, Haga, I, T. Takayama, A. Nakamura

TRANSPLANTATION　94　(10)　618-618　2012/11

ISSN： 0041-1337

eISSN： 1534-6080
A strong candidate approach to prevent the instant blood-mediated inflammatory reaction in clinical islet transplantation

Kazuaki Tokodai, Masafumi Goto, Akiko Inagaki, Wataru Nakanishi, Noriko Okada, Hidechika Okada, Susumu Satomi

XENOTRANSPLANTATION　16　(5)　300-300　2009/09

ISSN： 0908-665X

Show all ︎Show first 5

Presentations 11

補体結合性ドナー特異的抗HLA抗体のグラフト肝への影響

戸子台和哲

第55回日本移植学会総会　2019/10/11
肝移植領域におけるde novo DSAの意義と今後の課題 Invited

戸子台和哲

第55回日本移植学会総会　2019/10/11
Characteristics and risk factors of fatty liver disease development and nonalcoholic steatohepatitis recurrence after liver transplantation International-presentation

TOKODAI Kazuaki

Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association　2019/09/07
Association of posttransplant donor-specific HLA antibody with liver fibrosis after pediatric liver transplantation International-presentation

TOKODAI Kazuaki

Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association　2019/09/07
低侵襲細胞移植療法の確立を目的とした羊膜上皮細胞分離体制の構築

TOKODAI Kazuaki

2019/08/03
肝移植後ドナー特異的抗HLA抗体出現のリスク因子とグラフト肝に与える影響

戸子台和哲

第37回日本肝移植学会　2019/07/26
脂肪肝ドナー（macrovesicular steatosis＞30%）を用いた脳死肝移植の短期・中期成績

戸子台和哲

第37回日本肝移植学会　2019/07/25
1型糖尿病根治のための当施設のストラテジー－膵臓移植短期合併症の克服と低侵襲細胞治療の成績向上－

戸子台和哲

第119回日本外科学会総会　2019/04/19
腎移植ハイリスク症例へのストラテジーと今後の展望 Invited

戸子台和哲

第1回KTx Clinical Seminar　2019/03/15
DSA in liver transplantation International-presentation Invited

TOKODAI Kazuaki

ASIA PACIFIC TRANSPLANT CAUCUS 2019　2019/03/02
ABO血液型不適合肝移植の現状と新規プロトコールによる適応拡大 Invited

戸子台和哲

第206回日本消化器病学会東北支部例会　2019/02/09

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Research Projects 17

縫合不全および吻合部狭窄の予防を目的とした羊膜細胞による消化管吻合部補強材の開発

谷山裕亮, 亀井尚, 小澤洋平, 戸子台和哲, 佐藤千晃, 岡本宏史

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04/01 - 2028/03/31
Elucidation of the Mechanisms Underlying Intercellular Horizontal Mitochondrial Transfer

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Nihon University

2025/04/01 - 2028/03/31
羊膜由来幹細胞共移植による肝細胞移植生着効率向上法の開発

小笠原弘之, 齋藤昌利, 後藤昌史, 戸子台和哲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04/01 - 2028/03/31
ヒト羊膜上皮幹細胞由来肝細胞移植における拒絶反応・即時型炎症反応の解明と制御

戸子台和哲, 齋藤昌利, 後藤昌史, 三木敏生

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04/01 - 2028/03/31
Development of a Novel Liver Failure Therapy Based on Improvement of Energy Status of Hepatocytes by Oxygenated Perfusion

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2023/04/01 - 2026/03/31
食道癌術後反回神経麻痺の改善を目的とした羊膜細胞による神経損傷修復材の開発

谷山裕亮, 亀井尚, 小澤洋平, 戸子台和哲, 佐藤千晃

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
ヒト羊膜の創傷治癒促進作用に着目した新しい胆汁漏・膵液瘻治療法の開発

宮澤恒持, 齋藤昌利, 星合哲郎, 戸子台和哲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
羊膜由来幹細胞が肝内膵島生着環境に与える影響の解明

戸子台和哲, 齋藤昌利, 星合哲郎, 後藤昌史, 菅原宏文, 三木敏生

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
心停止肝に対する、酸素化灌流とMuse細胞移植を融合した臓器修復再生法の開発

宮城重人, 後藤昌史, 戸子台和哲, 柏舘俊明, 柿崎裕太

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2025/03/31

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一昨年から引き続き正常肝のラット過小グラフト移植モデルを作成し、こちらにヒトMuse 細胞および間葉系幹細胞（MSC)のブースト細胞移植モデルを付加する研究を継続した。20％過小グラフト肝移植＋細胞ブーストモデルを作成し、ブースト移植細胞数を、MSC40万個、Muse40万個、MSC500万個（MSC500万個中にMuse40万が存在すると想定できる）で比較検討した。過小グラフト肝移植＋ブースト細胞移植のモデルは既に当科で確立されているため、生存率には有意差が出なかったが、肝再生速度と肝代謝能力（ICG検査）の検討にてMuse40万個移植群は他群に比し有意にICG消失率が良好であった。STEM121というヒト特異的細胞質マーカーを用いたトレースではMuse群においてより多くのヒト由来細胞を認めた。次にICG検査が、MSC500万群で改善が不十分なのにMuseだけ改善した理由として、肝臓内の血流が改善した可能性を考え（つまりMSC500万群では細胞数が多すぎてかえって類洞閉塞した可能性を考えた）、臓器透明化技術を用いて肝類洞画像を撮影した。術後3日目のラットに蛍光標識デキストランを注射し、肝臓を摘出後、4%PFAにて浸漬固定。そのごCUBIC protocolを用いて肝臓を透明化し多光子共焦点レーザー顕微鏡にて3次元類洞画像を撮影。ImageJによる連続した平均類洞体積・表面積測定にて、類洞の開存性および連続性がMuse細胞40万投与で有意に改善していることが解った。さらに、Muse細胞はMSCと比較してHGF、VEGFAを高発現しているため、Muse細胞の類洞保護効果がHGFやVEGFAによるものと仮定し研究中である。心停止ドナー肝グラフトに酸素化灌流を施行する類洞保護モデルについても確立はされた。ラットにて無処置群と酸素化灌流群で比較研究を開始している。
ヒト羊膜の抗炎症・抗菌作用に着目した抗感染性人工血管の作成

中西渉, 戸子台和哲, 菅原宏文, 赤松大二朗, 齋藤昌利, 星合哲郎, 宮城重人

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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胸部・腹部大動脈瘤などの血管疾患に対し、人工血管を用いた血行再建術の有用性は確立され、血管外科領域の多くの手術において臨床使用されている。一方で、人工血管は人体にとって異物であることから一度感染を起こすと難治性であり、術後死亡に直結する重篤な合併症となることから、その予防が極めて重要である。大網や筋皮弁などの患者本人の体内組織を用いた人工血管被覆が感染予防法として実施されているが、これらを使用できないことも少なくなく、感染抵抗性の生体材料を用いた抗感染性人工血管を作成できれば血行再建術の成績をさらに安定化することができる。ヒト羊膜はコラーゲンやラミニンなどのタンパクの層から成る組織と1層の羊膜上皮細胞で構成される半透明の膜であり、廃棄される段階の分娩後胎盤から安価に採取することができる。抗炎症作用や血管新生促進作用、多分化能などとともに、抗菌作用を有することが基礎研究で示されており、眼科領域では羊膜移植がすでに保険診療として実施されている。本研究では、ヒト羊膜を用いた抗感染性人工血管の作成を目的として、小動物人工血管置換モデルと腹膜炎モデルを用いてヒト羊膜の人工血管感染予防効果を検証することを目的としている。本研究に必要なヒト羊膜の採取に関しては、倫理委員会での承認も得られ、産科を始めとする関係部署との協力体制は確立することができている。また、小動物人工血管置換モデルの作成についても、動物実験施設における実験実施体制を含め準備が整っている段階にある。一方で、腹膜炎モデルに関しては、局所に感染を起こしつつ、安定した全身状態を維持することが現時点では確立できておらず、今後の課題となっている。
The new method for the liver failure using the hybrid transplantation of the liver and Muse cells

Shigehito Miyagi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2020/03/31

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The treatment for the sinusoidal microcirculatory injury (SMI) induced by excessive shear stress to liver sinusoidal endothelial cells (LSECs) is necessary for the regeneration. Multilineage-differentiating Stress Enduring (Muse) cells selectively home to the injured organ and repair by spontaneously differentiation. We hypothesized that intravenous administration of Muse cells might improve SMI the sinusoid. Then we evaluated the protective effects of Muse cells using an extra-small partial liver transplantation model in rats. The analysis of liver sinusoidal images, indocyanine green test, immunohistochemical stain of LSECs revealed that sinusoidal continuity, volume and surface area were protected significantly by administrated Muse cells. Furthermore, Ki-67 positive ratio of hepatocyte is higher in Muse group. The combination of cell transplantation using Muse cells and organ transplantation of small-for-size grafts is effective as a treatment for end-stage of liver disease.
羊膜上皮細胞を用いた先天性代謝異常症に対する低侵襲細胞移植療法の確立 Competitive

戸子台和哲

Offer Organization: 公益財団法人小児医学研究振興財団

System: 平成30 年度研究助成金【小児科領域全般】

2019/04 - 2020/03
補体結合性抗HLA抗体とIgGサブクラスの臓器移植後慢性拒絶反応における役割 Competitive

戸子台和哲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

2017/04 - 2020/03
Novel diagnostic tool for drug-induced liver injury after liver transplantation

Takeda Ikuo

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2017/03/31

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We colected blood, urine, and liver tissue samples at fixed intervals after liver transplantation. DNA was extracted from frozen liver tissue, and RNA was extracted from lymphocyte cells obtained from blood samples. Using the DNA and RNA, Genetic polymorphism related to drug metabolism was analyzed using SNP (single nucleotide polymorphism) analysis. The association of genetic polymorphism with drug hepatopathy will be assessed when enough number of samples are accumulated.
Luminex法を用いた臓器移植後抗HLA抗体の慢性拒絶反応における役割の解明 Competitive

戸子台和哲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

2014/04 - 2017/03
ヒト羊膜由来細胞移植後の即時型炎症反応と免疫応答の解析と制御

Offer Organization: 日本臓器保存生物医学会
ヒト羊膜由来細胞と膵島の門脈内共移植による移植後早期膵島障害の克服

Offer Organization: 艮陵医学振興会

System: 安斎記念糖尿病研究助成

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