Details of the Researcher

PHOTO

Minoru Kurisu
Section
Graduate School of Science
Job title
Assistant Professor
Degree

  • 博士（理学）（東北大学）

  • 修士（理学）（東北大学）

e-Rad No.
00963943

Research History 4

  • 2022/04 - 2026/03
    Tohoku University　Graduate School of Science Department of Physics　Assistant Professor

  • 2021/04 - 2022/03
    Research Fellow (DC2) from the Japan Society for the Promotion of Science

  • 2019/07 - 2019/09
    Academic Guest, ETH Zürich Department of Materials

  • 2018/10 - 2018/12
    Visiting Student, ETH Zürich Department of Materials

Education 2

  • Tohoku University　Graduate School of Science　Department of Physics

    2017/04 - 2022/03

  • Tohoku University　Faculty of Science　Department of Physics

    2013/04 - 2017/03

Committee Memberships 2

  • Japanese Society for Origins of Life and Astrobiology　Organizing Committee

    2023/04 - Present

  • The Biophysical Society of Japan　Expert Committee (Non-equilibrium/Self-organization)

    2021/01 - 2022/12

Professional Memberships 4

  • The Society for the Study of the Origin and Evolution of Life Japan

    2022/04 - Present

  • Japanese Society For Cell Synthesis Research

    2019/09 - Present

  • The Biophysical Society of Japan

    2019/04 - Present

  • The Physical Society of Japan

    2017/03 - Present

Research Interests 6

  • Amphiphile

  • Artificial Cell

  • Vesicle

  • Protocell / Synthetic Cell

  • Biophysics

  • Soft Matter

Research Areas 1

  • Natural sciences / Bio-, chemical, and soft-matter physics /

Awards 8

  1. IUPAB award

    2023/11　International Union of Pure and Applied Biophysics　Reproduction of a synthetic minimal cell: An experimental approach connecting matter and cell

  2. Early Career Award in Biophysics

    2023/11　The Biophysical Society of Japan　Reproduction of a synthetic minimal cell: An experimental approach connecting matter and cell

  3. Student Presentation Award

    2022/03　The 46th Annual Meeting of The Society for the Study of the Origin and Evolution of Life Japan　Reproduction of Vesicles: Synthetic Design of Minimal Cells

  4. Thesis Award

    2022/02　Department of Physics, Graduate School of Science, Tohoku University　Recursive Vesicle Reproduction System Coupled with Enzymatic Cascade Reactions: Toward Synthetic Minimal Cell

  5. Student Presentation Award

    2021/11　The 59th Annual Meeting of the Biophysical Society of Japan　Reproduction cycles of vesicle coupled with template polymerization: toward autonomous synthetic protocell

  6. Poster Award

    2020/11　The 4th Symposium for The Core Research Cluster for Materials Science and the 3rd Symposium on International Joint Graduate Program in Materials Science

  7. Student Presentation Award

    2020/09　The 58th Annual Meeting of the Biophysical Society of Japan　Sustainable Reproduction of Vesicles coupled with a Surface-Confined Template Polymerization

  8. Best Poster Award

    2020/02　The 3rd Symposium for The Core Research Clusters for Materials Science and Spintronics

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Papers 10

  1. Osmotic spawning vesicle Peer-reviewed

    Minoru Kurisu, Masayuki Imai

    Soft Matter　20　(45)　8976-8989　2024/09

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4sm00915k 　

    ISSN： 1744-683X

    eISSN： 1744-6848

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    We discovered a novel division mechanism of vesicles. This simple and highly productive system will provide proliferation ability to existing and future microcompartment systems, simply by selecting suitable membrane compositions and osmolytes.

  2. Concepts of a synthetic minimal cell: Information molecules, metabolic pathways, and vesicle reproduction Invited Peer-reviewed

    Minoru Kurisu, Masayuki Imai

    Biophysics and Physicobiology　24　(1)　e210002　2024/01

    Publisher: Biophysical Society of Japan

    DOI： 10.2142/biophysico.bppb-v21.0002 　

    eISSN： 2189-4779

  3. Synthetic minimal cell with artificial metabolic pathways Peer-reviewed

    Minoru Kurisu, Peter Walde, Masayuki Imai

    Artificial Life Conference Proceedings (MIT Press)　isal_a_00610　25　2023/07

    DOI： 10.1162/isal_a_00610 　

  4. The origin of cellular systems from vesicles Invited Peer-reviewed

    Minoru Kurisu, Masayuki Imai

    Viva Origino　51　(2)　3　2023/04/01

    DOI： 10.50968/vivaorigino.51_3 　

    ISSN： 0910-4003 1346-6933

  5. Synthesising a minimal cell with artificial metabolic pathways Peer-reviewed

    Minoru Kurisu, Ryosuke Katayama, Yuka Sakuma, Toshihiro Kawakatsu, Peter Walde, Masayuki Imai

    Communications Chemistry　6　(1)　56　2023/03/28

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42004-023-00856-y 　

    eISSN： 2399-3669

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    Abstract A “synthetic minimal cell” is considered here as a cell-like artificial vesicle reproduction system in which a chemical and physico-chemical transformation network is regulated by information polymers. Here we synthesise such a minimal cell consisting of three units: energy production, information polymer synthesis, and vesicle reproduction. Supplied ingredients are converted to energy currencies which trigger the synthesis of an information polymer, where the vesicle membrane plays the role of a template. The information polymer promotes membrane growth. By tuning the membrane composition and permeability to osmolytes, the growing vesicles show recursive reproduction over several generations. Our “synthetic minimal cell” greatly simplifies the scheme of contemporary living cells while keeping their essence. The chemical pathways and the vesicle reproduction pathways are well described by kinetic equations and by applying the membrane elasticity model, respectively. This study provides new insights to better understand the differences and similarities between non-living forms of matter and life.

  6. From vesicles toward protocells and minimal cells Invited Peer-reviewed

    Masayuki Imai, Yuka Sakuma, Minoru Kurisu, Peter Walde

    Soft Matter　18　4823-4849　2022/06

    Publisher: Royal Society of Chemistry ({RSC})

    DOI： 10.1039/D1SM01695D 　

    ISSN： 1744-683X

    eISSN： 1744-6848

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    In contrast to ordinary condensed matter systems, “living systems” are unique. They are based on molecular compartments that reproduce themselves through (i) an uptake of ingredients and energy from the...

  7. Recursive vesicle reproduction system coupled with enzymatic cascade reactions: Toward synthetic minimal cell

    Minoru Kurisu

    PhD Thesis　2022/02

  8. Growth and Division of Vesicles Coupled with Information Molecules Invited Peer-reviewed

    Minoru KURISU, Masayuki IMAI, Peter WALDE

    Seibutsu Butsuri　61　(6)　378-381　2021/11

    Publisher: Biophysical Society of Japan

    DOI： 10.2142/biophys.61.378 　

    ISSN： 0582-4052

    eISSN： 1347-4219

  9. Application of an enzymatic cascade reaction for the synthesis of the emeraldine salt form of polyaniline Peer-reviewed

    Minoru Kurisu, Reinhard Kissner, Masayuki Imai, Peter Walde

    Chemical Papers　75　(10)　5071-5085　2021/10/13

    Publisher: Springer Science and Business Media {LLC}

    DOI： 10.1007/s11696-021-01620-z 　

    ISSN： 0366-6352

    eISSN： 2585-7290

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    <title>Abstract</title>The synthesis of the emeraldine salt form of polyaniline (PANI-ES) from aniline with <italic>Aspergillus</italic> sp. glucose oxidase (GOD), <sc>d</sc>-glucose, dissolved O2, and horseradish peroxidase isoenzyme C (HRPC) in the presence of large unilamellar vesicles of AOT (sodium bis-(2-ethylhexyl)sulfosuccinate) as templates at pH = 4.3 and <italic>T</italic> ~ 25 °C was investigated in a systematic way. In this cascade reaction mixture, the oxidation of aniline is catalyzed by HRPC with H2O2 that is formed in situ as byproduct of the GOD-catalyzed oxidation of <sc>d</sc>-glucose with O2. Under the elaborated experimental conditions which we considered ideal, the formation of PANI-ES products is evident, as judged by UV/Vis/NIR and EPR measurements. Comparison was made with a reference reaction, which was run under similar conditions with added H2O2 instead of GOD and <sc>d</sc>-glucose. Although the reference reaction was found to be superior, with the cascade reaction, PANI-ES products can still be obtained with high aniline conversion (&gt; 90%) within 24 h as stable dark green PANI-ES/AOT vesicle dispersion. Our results show that the in situ formation of H2O2 does not prevent the inactivation of HRPC known to occur in the reference reaction. Moreover, the GOD used in the cascade reaction is inactivated as well by polymerization intermediates.

  10. Reproduction of vesicles coupled with a vesicle surface-confined enzymatic polymerisation International-journal Peer-reviewed

    Minoru Kurisu, Harutaka Aoki, Takehiro Jimbo, Yuka Sakuma, Masayuki Imai, Sandra Serrano-Luginbühl, Peter Walde

    Communications Chemistry　2　(117)　1-10　2019/10/11

    Publisher: Springer Science and Business Media {LLC}

    DOI： 10.1038/s42004-019-0218-0 　

    ISSN： 2399-3669

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Presentations 19

  1. 溶質分子の非対称な膜透過が駆動するベシクルの自発的大量分裂の発見

    栗栖実, 今井正幸

    日本物理学会 2025年春季大会　2025/03/20

  2. 透圧が駆動する脂質膜ベシクルの出芽型分裂現象の発見

    栗栖実

    2024年度日本生物物理学会北海道支部－東北支部合同例会　2025/02/21

  3. 浸透圧下におけるベシクルの自発的大量分裂

    栗栖 実

    ソフトマター若手研究会　2024/11/09

  4. 自己生産する人工細胞系のボトムアップ構築：化学反応系と膜弾性モデル Invited

    栗栖実

    東京大学生物普遍性研究機構 生物普遍性セミナー（共催 学術変革領域(A) 超越分子システム）　2024/08/08

  5. 膜成長と分裂を実現する単純なベシクル系の探索：膜から探るプロトセル

    栗栖実, 馬場晶子, 今井正幸

    第48回生命の起原および進化学会学術講演会　2024/03/29

  6. 分裂可能な原始細胞膜の分子組成探索 Invited

    栗栖実

    第12回宇宙における生命ワークショップ　2024/02/17

  7. Reproduction of a synthetic minimal cell: An experimental approach connecting matter and cell Invited

    MInoru Kurisu, Peter Walde, Masayuki Imai

    The 61st Annual Meeting of the Biophysical Society of Japan　2023/11/14

  8. 自己生産する人工細胞の設計：酵素反応・重合反応・膜弾性モデル Invited

    栗栖 実

    第38回中国四国地区高分子若手研究会　2023/11/01

  9. 物質と細胞を人工のベシクル自己生産系で繋ぐ Invited

    栗栖 実

    生命の起原および進化学会 夏の学校　2023/09/04

  10. Synthesizing a minimal cell with artificial metabolic pathways

    Minoru Kurisu, Peter Walde, Masayuki Imai

    Statphys 28　2023/08/11

  11. Synthetic minimal cells as a physical model of protocells

    Minoru Kurisu, Peter Walde, Masayuki Imai

    Origins 2023　2023/08/03

  12. Synthetic minimal cell with artificial metabolic pathways

    Minoru Kurisu, Peter Walde, Masayuki Imai

    ALIFE 2023　2023/07/28

  13. 自己生産するマイクロ膜コンパートメント Invited

    栗栖実

    CHEMINAS47 (化学とマイクロ・ナノシステム学会 第47回研究会)　2023/05/14

  14. Synthesizing a minimal cell with artificial metabolic pathways

    The Society for the Study of the Origin and Evolution of Life : Asrobiology-Japan　2023/03/28

  15. ベシクルの自己生産: 人工的なミニマルセルのデザイン

    栗栖実, Peter Walde, 今井正幸

    第46回 生命の起原および進化学会学術講演会　2022/03/22

  16. Reproduction cycles of vesicle coupled with template polymerization: toward autonomous synthetic protocell.

    Minoru Kurisu, Ryosuke Katayama, Yuka Sakuma, Peter Walde, Masayuki Imai

    第59回日本生物物理学会年会　2021/11/26

  17. Sustainable reproduction of vesicles coupled with surface confined template polymerization Invited

    Minoru Kurisu

    The 4th Symposium for The Core Research Cluster for Materials Science and the 3rd Symposium on International Joint Graduate Program in Materials Science　2020/11/16

  18. Sustainable reproduction of vesicles coupled with surface confined template polymerization Invited

    Minoru Kurisu

    From Soft Matter to Protocell 2020　2020/10/29

  19. ベシクルと情報高分子の連携による自己複製システム

    栗栖実, 青木春隆, 佐久間由香, 今井正幸, Sandra Luginbühl, Peter Walde

    日本物理学会2018年春季大会　2018/03/23

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Research Projects 6

  1. Evolvable Self-Reproducing Minimal Cells: Toward Artificial Living Systems

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  2. Development of microscale membrane compartments showing inflation and division

    Offer Organization: Japan Science and Technology Agency

    System: JST Strategic Basic Research Programs ACT-X

    Institution: Tohoku University

    2023/10 - 2026/03

  3. ベシクルからミニマルセルへの道：代謝・自己生産・進化

    栗栖 実

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2023/04 - 2026/03

  4. 原始細胞分裂に着目した生命痕跡の解析方法の提案

    栗栖実

    Offer Organization: 自然科学研究機構アストロバイオロジーセンター

    System: 令和５年度プロジェクト研究

    Category: 受託研究

    2023/04 - 2024/03

  5. Reproduction and evolution of minimal cell: soft matter physics connecting matter and life

    Minoru Kurisu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2022/08 - 2024/03

  6. Self-organization of molecular assembly to living system: synthesis of minimal cell

    Minoru Kurisu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Tohoku University

    2021/04 - 2023/03

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Media Coverage 1

  1. 自然に分裂する人工細胞

    日経サイエンス2024年12月号

    2024/10

    Type: Newspaper, magazine