Details of the Researcher

PHOTO

Yumi Takano
Section
Tohoku University Hospital
Job title
Assistant Professor

Research Areas 1

  • Life sciences / Neuroscience - general /

Papers 29

  1. Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers. International-journal

    Taizen Nakase, Yumi Takano, Shuko Nomura, Hae Woon Baek, Shin Takayama, Rie Ono, Michiaki Abe, Tadashi Ishii, Yasuko Tatewaki, Yasuyuki Taki

    Journal of the neurological sciences　483　125808-125808　2026/04/15

    DOI： 10.1016/j.jns.2026.125808 　

    More details Close

    BACKGROUND: Some patients recovered from COVID-19 may experience cognitive and psychological symptoms, such as "brain fog" or neuropsychological long COVID, and its mechanism is unclear. OBJECTIVE: This study aimed to investigate the mechanism of brain damage in neuropsychological long COVID using imaging and blood biomarkers. METHODS: Patients who met the criteria on the "brain fog" screening questionnaire and provided informed consent were enrolled in this study (n = 33; mean age 38.5 years). All participants were examined using magnetic resonance imaging, single-photon emission computed tomography (assessment of regional cerebral blood flow [rCBF]), and blood biomarkers. Neuropsychological tests (Montreal Cognitive Assessment-Japanese version [MoCA-J], Trail Making Test [TMT], Frontal Assessment Battery, Digital Symbol Coding [DSC] test, State-Trait Anxiety Inventory [STAI], and Self-Rating Depression Scale [SDS]) were performed simultaneously. RESULTS: Significant correlations were observed between the MoCA-J score and decreased rCBF in the left occipital lobe and increased rCBF in the right occipital lobe (p < 0.05), between the STAI score and decreased rCBF in the right parietal lobe (p < 0.05), and between the SDS score and decreased rCBF in the right parietal lobe (p < 0.05). The MoCA-J and DSC scores were correlated with plasma levels of neurofilament light chain (p < 0 0.05). The TMT time correlated with plasma glial fibrillary acidic protein levels (p < 0.01). CONCLUSION: This study was a cross-sectional and could not distinguish pathological abnormalities. However, as correlations of neuropsychological long COVID with specific brain regions and plasma biomarkers have been elucidated, conducting a case-control analysis may be worthwhile.

  2. Blood Biomarkers Reflect Dementia Symptoms and Are Influenced by Cerebrovascular Lesions. International-journal

    Taizen Nakase, Yasuko Tatewaki, Yumi Takano, Shuko Nomura, Hae Woon Baek, Yasuyuki Taki

    International journal of molecular sciences　26　(5)　2025/03/05

    DOI： 10.3390/ijms26052325 　

    More details Close

    Dementia blood biomarkers are becoming increasingly important. Various factors, such as ischemic lesions and inflammation, can influence the pathomechanism of dementia. We aimed to evaluate the effects of past stroke lesions on blood biomarkers (BMs). Following approval from the institutional ethics committee, patients who were admitted to the memory clinic and were consented to written documents were enrolled (n = 111, average [standard deviation] age: 74.5 [9.1] years-old). Brain magnetic resonance imaging, cognitive function, and neuropsychological symptoms were analyzed. The amyloid-β 42 (Aβ42)/Aβ40 ratio, phosphorylated tau181 (p-tau181), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and Aβ42/p-tau181 ratio were assessed as plasma BMs. The patients were diagnosed with Alzheimer's disease (n = 45), mild cognitive impairment (n = 56), depression (n = 8), and subjective cognitive impairment (n = 4). Bivariate analysis exhibited that all measured BM indicators were significantly associated with cognitive decline in patients without past stroke lesions. Whereas the patients with stroke lesions presented a significant association only between GFAP and cognitive decline (p = 0.0011). Multiple regression analysis showed that NfL significantly correlated with cognitive decline only in patients without stroke lesions (r = 0.4988, p = 0.0003) and with delusion only in those with stroke lesions (r = 0.5492, p = 0.0121). Past stroke lesions should be addressed in the assessment of the correlation between blood biomarkers and cognitive decline in dementia patients.

  3. Association between Gray and White Matter Lesions and Its Involvement in Clinical Symptoms of Alzheimer's-Type Dementia. International-journal

    Taizen Nakase, Benjamin Thyreau, Yasuko Tatewaki, Naoki Tomita, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    Journal of clinical medicine　12　(24)　2023/12/12

    DOI： 10.3390/jcm12247642 　

    More details Close

    BACKGROUND: Not only gray matter lesions (GMLs) but also white matter lesions (WMLs) can play important roles in the pathology of Alzheimer's disease (AD). The progression of cognitive impairment (CI) and behavioral and psychological symptoms of dementia (BPSD) might be caused by a concerted effect of both GML and WML. OBJECTIVE: This study aimed to investigate the association between GML and WML and how they are involved in the symptoms of CI and BPSD in dementia patients by means of imaging technology. METHODS: Patients in our memory clinic, who were diagnosed with AD-type dementia or amnestic mild cognitive impairment (aMCI) and had undergone both single-photon emission computed tomography (SPECT) and brain MRI, were consecutively enrolled (n = 156; 61 males and 95 females; 79.8 ± 7.4 years old). Symptoms of CI and BPSD were obtained from patients' medical records. For the analysis of GMLs and WMLs, SPECT data and MRI T1-weighted images were used, respectively. This study followed the Declaration of Helsinki, and all procedures were approved by the institutional ethics committee. RESULTS: According to a multivariate analysis, disorientation and disturbed attention demonstrated a relationship between the precuneus and WMLs in both hemispheres. Hyperactivity in BPSD showed multiple correlations between GMLs on both sides of the frontal cortex and WMLs. Patients with aMCI presented more multiple correlations between GMLs and WMLs compared with those with AD-type dementia regarding dementia symptoms including BPSD. CONCLUSION: The interaction between GMLs and WMLs may vary depending on the symptoms of CI and BPSD. Hyperactivity in BPSD may be affected by the functional relationship between GMLs and WMLs in the left and right hemispheres. The correlation between GMLs and WMLs may be changing in AD-type dementia and aMCI.

  4. アルツハイマー型認知症の臨床症状における大脳皮質および白質病変の関与についての検討

    中瀬 泰然, 舘脇 康子, 冨田 尚希, 村中 美千帆, 高野 由美, 山本 修三, 瀧 靖之

    日本内科学会雑誌　112　(臨増)　160-160　2023/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  5. Impact of atrial fibrillation on the cognitive decline in Alzheimer's disease. International-journal

    Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    Alzheimer's research & therapy　15　(1)　15-15　2023/01/13

    DOI： 10.1186/s13195-023-01165-1 　

    More details Close

    BACKGROUND: Atrial fibrillation (AF) is a strong risk factor for Alzheimer's disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated. We aimed to investigate the clinical differences between dementia patients with AF and those without AF by means of imaging data. METHODS: Following approval from the institutional ethics committee, patients with newly diagnosed AD or amnestic mild cognitive impairment (aMCI) were retrospectively screened (n = 170, 79.5 ± 7.4 years old). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Based on the MRI data, the cerebral volume, cerebral microbleeds (CMBs), periventricular white matter lesions (WMLs), and deep WMLs were evaluated. The regional cerebral blood flow (rCBF) was measured using 123I-IMP SPECT. RESULTS: Of the patients, 14 (8.2%) and 156 (91.8%) had AF (AF group) and sinus rhythm (SR group), respectively. The AF group had significantly lower MMSE scores than the SR group (average [standard deviation (SD)]: 19.4 [4.4] and 22.0 [4.4], respectively; p = 0.0347). Cerebral volume and CMBs did not differ between the two groups. The periventricular WMLs, but not the deep WMLs, were significantly larger in the AF group than in the SR group (mean [SD] mL: 6.85 [3.78] and 4.37 [3.21], respectively; p = 0.0070). However, there was no significant difference in rCBF in the areas related to AD pathology between the two groups. CONCLUSION: AD and aMCI patients with AF showed worse cognitive decline along with larger periventricular WMLs compared to those with SR, although the reduction of rCBF was not different between patients with AF and SR. The white matter lesions may be a more important pathology than the impairment of cerebral blood flow in dementia patients with AF. A larger study is needed to confirm our findings in the future.

  6. Impact of constipation on progression of Alzheimer's disease: A retrospective study. International-journal

    Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Tatsushi Mutoh, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

    CNS neuroscience & therapeutics　28　(12)　1964-1973　2022/12

    DOI： 10.1111/cns.13940 　

    More details Close

    BACKGROUND AND PURPOSE: In terms of the gut-brain axis, constipation has been considered to be an important factor of neurodegenerative diseases, although the exact mechanism is still controversial. Herein, we aimed to investigate the contribution of constipation to the progression of dementia in a retrospective study. METHODS: Patients of Alzheimer's disease(AD) and amnestic mild cognitive impairment were consecutively screened between January 2015 and December 2020, and those of whom brain MRI and neuropsychological tests were performed twice were enrolled in this study. Participants were classified into with constipation (Cons[+], n = 20) and without constipation (Cons[-], n = 64) groups. Laboratory data at the first visit were used. Regression analysis was performed in MMSE, ADAS-Cog, and the volumes of hippocampus on MRI-MPRAGE images and deep white matter lesions (DWMLs) on MRI-FLAIR images obtained at two different time points. RESULTS: The main finding was that the Cons[+] group showed 2.7 times faster decline in cognitive impairment compared with the Cons[-] group, that is, the liner coefficients of ADAS-Cog were 2.3544 points/year in the Cons[+] and 0.8592 points/year in the Cons[-] groups. Ancillary, changes of DWMLs showed significant correlation with the time span (p < 0.01), and the liner coefficients of DWMLs were 24.48 ml/year in the Cons[+] and 14.83 ml/year in the Cons[-] group, although annual rate of hippocampal atrophy was not different between the two groups. Moreover, serum homocysteine level at baseline was significantly higher in the Cons[+] group than Cons[-] group (14.6 ± 6.4 and 11.5 ± 4.2 nmol/ml, respectively: p = 0.03). CONCLUSION: There is a significant correlation between constipation and faster progression of AD symptoms along with expansion of DWMLs.

  7. MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

    村中 美千帆, 舘脇 康子, Benjamin Thyreau, 阪本 真弥, 高野 由美, 山本 修三, 冨田 尚希, 中瀬 泰然, 瀧 靖之

    老年精神医学雑誌　33　(増刊II)　265-265　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  8. アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

    中瀬 泰然, 冨田 尚希, 舘脇 康子, 高野 由美, 村中 美千帆, 山本 修三, 瀧 靖之

    老年精神医学雑誌　33　(増刊II)　288-288　2022/11

    Publisher: (株)ワールドプランニング

    ISSN： 0915-6305

  9. MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

    村中 美千帆, 舘脇 慶子, Benjamin Thyreau, 阪本 真弥, 高野 由美, 山本 修三, 冨田 尚希, 中瀬 泰然, 瀧 靖之

    Dementia Japan　36　(4)　761-761　2022/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  10. アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

    中瀬 泰然, 冨田 尚希, 舘脇 康子, 高野 由美, 村中 美千帆, 山本 修三, 瀧 靖之

    Dementia Japan　36　(4)　771-771　2022/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  11. コロナワクチン接種後に多臓器の障害が見られた高齢認知症の1例

    村中 美千帆, 冨田 尚希, 中瀬 泰然, 高野 由美, 山本 修三, 舘脇 康子, 武藤 達士, 瀧 靖之

    日本老年医学会雑誌　59　(4)　574-574　2022/10

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  12. アルツハイマー型認知症の進行に影響する心房細動についての検討

    中瀬 泰然, 舘脇 康子, Thyreau Benjamin, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    日本老年医学会雑誌　59　(Suppl.)　104-104　2022/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  13. Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet. International-journal

    Junpei Takeishi, Yasuko Tatewaki, Taizen Nakase, Yumi Takano, Naoki Tomita, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki

    International journal of molecular sciences　22　(22)　2021/11/15

    DOI： 10.3390/ijms222212310 　

    More details Close

    Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer's disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accumulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.

  14. アルツハイマー病の進行に関与する便秘の影響についての検討

    中瀬 泰然, 舘脇 康子, Thyreau Benjamin, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    Dementia Japan　35　(4)　614-614　2021/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  15. 認知症病態に関わる心房細動の影響についての検討

    中瀬 泰然, 竹石 潤平, 舘脇 康子, Benjamin Thyreau, 武藤 達士, 冨田 尚希, 山本 修三, 高野 由美, 村中 美千帆, 瀧 靖之

    Dementia Japan　35　(4)　620-620　2021/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  16. 心房細動のアブレーション治療による認知機能改善効果と局所脳血流の変化に関する検討

    榎 亮, 舘脇 康子, 山本 修三, 佐藤 弘和, 小林 亜紀子, 戸恒 智子, 高野 由美, 武藤 達士, 八木 哲夫, 瀧 靖之

    Dementia Japan　34　(4)　492-492　2020/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  17. 非痙攣性てんかん重積の早期診断にMRI-ASL灌流画像が有用であった症例

    山本 修三, 武藤 達士, 舘脇 康子, 高野 由美, 鶴谷 尚信, 渡部 憲昭, 斎藤 博, 米谷 元裕, 荒井 啓行, 瀧 靖之, 安井 信之

    Dementia Japan　34　(4)　497-497　2020/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  18. Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment? Peer-reviewed

    Keishi Miyazawa, Hisanori Fukunaga, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki

    International Journal of Molecular Sciences　21　(16)　5783-5783　2020/08/12

    Publisher: MDPI AG

    DOI： 10.3390/ijms21165783 　

    eISSN： 1422-0067

    More details Close

    Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the group of lipid mediators that actively regulate it—i.e., specialized pro-resolving lipid mediators (SPMs)—attracted attention in recent years as therapeutic targets. This review focuses on the following three specific SPMs and summarizes their relationships to AD, as they were shown to effectively address and reduce the risk of AD-related neuroinflammation: maresin 1 (MaR1), resolvin D1 (RvD1), and neuroprotectin D1 (NPD1). These three SPMs are metabolites of docosahexaenoic acid (DHA), which is contained in fish oils and is thus easily available to the public. They are expected to become incorporated into promising avenues for preventing and treating AD in the future.

  19. Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease

    Yumi Takano, Yasuko Tatewaki, Tatsushi Mutoh, Naoya Morota, Izumi Matsudaira, Benjamin Thyreau, Tatsuo Nagasaka, Hayato Odagiri, Shuzo Yamamoto, Hiroyuki Arai, Yasuyuki Taki

    Frontiers in Aging Neuroscience　12　2020/06/17

    Publisher: Frontiers Media SA

    DOI： 10.3389/fnagi.2020.00178 　

    eISSN： 1663-4365

  20. Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer's disease. International-journal Peer-reviewed

    Yumi Takano, Tatsushi Mutoh, Yasuko Tatewaki, Toshiki Seki, Shuzo Yamamoto, Hayato Odagiri, Hiroyuki Arai, Yasuyuki Taki

    Clinical and experimental pharmacology & physiology　47　(3)　365-371　2020/03

    DOI： 10.1111/1440-1681.13217 　

    ISSN： 0305-1870

    More details Close

    Accelerated bone loss is closely associated with Alzheimer's disease (AD), but the relationship between bone mineral density (BMD) and imaging markers of neurodegeneration remains uncertain. We examined the effect of low bone mass (osteopenia) on regional cerebral blood flow (rCBF) in patients with AD (n = 19) and non-demented aging (n = 12). We enrolled 31 female outpatients diagnosed with osteopenia (age ≥ 65 years) who had both a single-photon emission computed tomography brain scan and dual-energy X-ray absorptiometry bone scan taken at their initial investigation. We analyzed the relationship between osteopenia (-2.5 < T-score < -1) and rCBF in 62 cortical areas measured using the stereotactic extraction estimation analysis on single-photon emission computed tomography (SPECT) (mean Z-scores). We found that the mean Z-scores of 14 cerebral subregions, most of which are often affected early in AD, were significantly lower in the AD group than the non-demented group (P < .001). The age-stratified multivariate regression analysis showed that the decreased rCBF in the left posterior cingulate cortex (PCC) was an independent predictor of osteopenia (r = -0.395; P = .005). BMD and rCBF in the left PCC were significantly correlated in the overall population (r = -0.54; P = .001), as well as the AD group (r = -0.514; P = .02). These imaging data suggest that osteopenia may contribute to neurodegeneration of a brain network hub associated with AD.

  21. 高齢女性の骨量減少とアルツハイマー型認知症の脳血流低下領域との関係

    関 俊樹, 武藤 達士, 高野 由美, 山本 修三, 舘脇 康子, 荒井 啓行, 瀧 靖之

    Dementia Japan　33　(4)　553-553　2019/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  22. Assessment of gait symmetry in elderly women with low bone mineral density using a portable trunk accelerometer: A pilot study Peer-reviewed

    Yumi Takano, Tatsushi Mutoh, Yasuko Tatewaki, Shuzo Yamamoto, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki

    Medical Science Monitor　25　6669-6674　2019/09/05

    DOI： 10.12659/MSM.916763 　

    ISSN： 1234-1010

    eISSN： 1643-3750

  23. 高齢女性の骨量減少と認知機能に関連した脳血流低下領域との関係 医用画像による骨-脳連関の視覚化

    高野 由美, 武藤 達士, 舘脇 康子, 山本 修三, 荒井 啓行, 瀧 靖之

    日本骨粗鬆症学会雑誌　5　(Suppl.1)　317-317　2019/09

    Publisher: (一社)日本骨粗鬆症学会

    ISSN： 2189-8383

  24. 高齢者の急性脳梗塞に対する積極的治癒の適応と予後に関する検討

    山本 修三, 武藤 達士, 鶴谷 尚信, 渡部 憲明, 米谷 元裕, 高野 由美, 冲永 壯治, 安井 信之, 荒井 啓行, 瀧 靖之

    日本老年医学会雑誌　56　(Suppl.)　153-153　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  25. 高齢者の慢性硬膜下血腫に対する外科治療と予後 新定義案に基づいた年齢別検討

    山本 修三, 武藤 達士, 渡部 憲昭, 鶴谷 尚信, 高野 由美, 舘脇 康子, 米谷 元裕, 安井 信之, 荒井 啓行, 瀧 靖之

    日本老年医学会雑誌　56　(Suppl.)　167-168　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  26. Isolated Fornix Infarction with Damage to the Limbic System as a Cause of Persistent Amnesia: A Case Report. International-journal Peer-reviewed

    Yumi Takano, Yasuko Tatewaki, Tatsushi Mutoh, Yamato Ohara, Shuzo Yamamoto, Yasuyuki Taki

    The American journal of case reports　19　1382-1385　2018/11/21

    DOI： 10.12659/AJCR.912508 　

    More details Close

    BACKGROUND The fornix is a white matter tract bundle that acts as the major output of the hippocampus and is an important component of the Papez circuit. We present an instructive imaging case of sudden onset of persistent amnesia due to selective ischemic damage of the anterior fornix. CASE REPORT A 54-year-old Japanese male came to our attention for a sudden onset of retrograde amnesia, associated with severe anterograde amnesia. The brain magnetic resonance imaging demonstrated a bright diffusion restriction, which was associated with swollen fornices bilaterally. His symptoms gradually improved, but episodic memory impairment still persisted after 1 month. The coronal T1-weighted MPRAGE (magnetization-prepared rapid acquisition with gradient echo) sequence clearly showed disruption of the left anterior fornix. Diffusion tensor tracking showed decrease in the density of entire fiber tracts on the Papez circuit as well as location of the left fornix. CONCLUSIONS When dealing with sudden, persistent amnesia associated with small fornix infarction, it is prudent to consider the possibility of tract damage along with limbic system damage using MPRAGE sequence.

  27. アルツハイマー型認知症に関わる脳領域の灰白質体積と骨密度の相関

    諸田 直哉, 舘脇 康子, 松平 泉, 高野 由美, 國時 景子, 戸恒 智子, 山本 修三, 武藤 達士, 荒井 啓行, 瀧 靖之

    日本骨粗鬆症学会雑誌　4　(Suppl.1)　391-391　2018/09

    Publisher: (一社)日本骨粗鬆症学会

    ISSN： 2189-8383

  28. Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage Peer-reviewed

    Tatsushi Mutoh, Kazumasu Sasaki, Yasuko Tatewaki, Keiko Kunitoki, Yumi Takano, Yasuyuki Taki

    Clinical and Experimental Pharmacology and Physiology　45　(4)　344-348　2018/04/01

    Publisher: Blackwell Publishing

    DOI： 10.1111/1440-1681.12874 　

    ISSN： 1440-1681 0305-1870

  29. Posterior associative and cingulate cortex involvement of brain single-photon emission computed tomography (Spect) imaging in semantic dementia with probable alzheimer disease pathology: A case report Peer-reviewed

    Yumi Takano, Keiko Kunitoki, Yasuko Tatewaki, Tatsushi Mutoh, Tomoko Totsune, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki

    American Journal of Case Reports　19　153-157　2018/02/12

    Publisher: International Scientific Information, Inc.

    DOI： 10.12659/AJCR.907799 　

    ISSN： 1941-5923

Show all ︎Show first 5

Misc. 15

  1. 認知機能障害患者における難聴と脳構造の変化

    奈良林愛美, 舘脇康子, 大場健太郎, 白海雲, 野村脩子, 高野由美, 中瀬泰然, 永坂竜男, 瀧靖之, 瀧靖之

    Dementia Japan　38　(4)　2024

    ISSN： 1342-646X

  2. 臨床的アルツハイマー病疑い患者におけるアミロイドPETとSPECT・MMSEの関連性の検討

    山崎 真瞳子, 舘脇 康子, 中瀬 泰然, 村中 美千帆, 高野 由美, 冨田 尚希, 児玉 裕康, 瀧 靖之

    Dementia Japan　37　(4)　657-657　2023/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  3. ポリファーマシーに関連した問題点の適正化が主要な診療となった5症例の検討

    冨田 尚希, 村中 美千帆, 舘脇 康子, 高野 由美, 山本 修三, 中瀬 泰然, 瀧 靖之

    日本老年医学会雑誌　60　(4)　457-457　2023/10

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  4. Impact of Atrial Fibrillation on Cognitive Impairment in Dementia Patients

    NAKASE Taizen, TATEWAKI Yasuko, TOMITA Naoki, ODAGIRI Hayato, TAKANO Yumi, MURANAK Michiho, TAKI Yasuyuki

    日本神経学会学術大会プログラム・抄録集　64th　2023

  5. PERCEIVED SOCIAL ISOLATION IS CORRELATED WITH BRAIN STRUCTURE AND COGNITIVE TRAJECTORY IN ALZHEIMER'S DISEASE

    Ye Zhang, Yasuko Tatewaki, Yingxu Liu, Naoki Tomita, Yumi Takano, Taizen Nakase, Tatsushi Mutoh, Yasuyuki Taki

    INNOVATION IN AGING　6　772-773　2022/11

    eISSN： 2399-5300

  6. 高齢女性の骨量減少とアルツハイマー型認知症の脳血流低下領域との関係

    関 俊樹, 武藤 達士, 高野 由美, 山本 修三, 舘脇 康子, 荒井 啓行, 瀧 靖之

    Dementia Japan　33　(4)　553-553　2019/10

    Publisher: (一社)日本認知症学会

    ISSN： 1342-646X

  7. アルツハイマー型認知症に関わる脳領域の灰白質体積と骨密度の相関 Bone-brain crosstalkの画像医学的検証

    高野 由美, 舘脇 康子, 武藤 達士, 山本 修三, 諸田 直哉, 松平 泉, 小田桐 逸人, 冲永 壯治, 荒井 啓行, 瀧 靖之

    日本老年医学会雑誌　56　(Suppl.)　170-170　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  8. 一般内科医における骨粗鬆症の診断能向上のために―SQ法とDXA法の比較検討―

    國時景子, 舘脇康子, 中川学, 高野由美, 戸恒智子, 武藤達士, 荒井啓行, 瀧靖之

    日本老年医学会雑誌　55　(Suppl.)　160-160　2018/05/25

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  9. 当科で一年間に経験した成人Still病4症例の検討

    高野由美, 高橋広喜, 森俊一, 鈴木森香, 田所慶一, 高橋裕一

    日本病院総合診療医学会雑誌　13　(1)　100　2017/07/31

    ISSN： 2185-8136

  10. MRSA菌血症に合併した腸腰筋膿瘍の1例

    熊坂衣織, 高橋広喜, 藤川祐子, 森俊一, 鈴木森香, 高野由美

    仙台医療センター医学雑誌(Web)　7　(1)　2017

    ISSN： 2186-3946

  11. 高齢者に発症した筋強剛を伴わない悪性症候群の一例

    森俊一, 高橋広喜, 鈴木森香, 高野由美, 田所慶一

    日本病院総合診療医学会雑誌　11　(2)　193　2016/12/22

    ISSN： 2185-8136

  12. 髄膜炎と鑑別を要したcrowned dens syndromeの1例

    高野由美, 高橋広喜, 森俊一, 鈴木森香, 田所慶一, 高橋裕一

    仙台医療センター医学雑誌(Web)　6　(1)　65‐68 (WEB ONLY)　2016/12/01

    ISSN： 2186-3946

  13. Stage1の乳癌術後に妊娠・出産し,食欲不振・歩行困難の出現で明らかになった多発骨転移の1例

    高野由美, 高橋広喜, 森俊一, 鈴木森香, 渡邊隆紀, 田所慶一

    日本病院総合診療医学会雑誌　10　(2)　157　2016/06/30

    ISSN： 2185-8136

  14. 認知症の周辺症状や夜間せん妄に対する漢方薬抑肝散の治療効果の検討

    森俊一, 高野由美, 高橋広喜, 鈴木森香, 田所慶一

    日本プライマリ・ケア連合学会学術大会抄録集　7th　276　2016

  15. 下腿浮腫を契機に診断された幽門輪温存胃亜全摘術,空腸間置再建術後のビタミンB1欠乏症の1例

    森俊一, 高橋広喜, 高野由美, 小高尚子, 横山寿行, 田所慶一

    仙台医療センター医学雑誌(Web)　5　(1)　2015

    ISSN： 2186-3946

Show all ︎Show first 5

Research Projects 1

  1. 骨－脳連関に着目した高齢者コグニティブ・フレイルの神経基盤の解明

    高野 由美, 舘脇 康子, 武藤 達士

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2019/04/01 - 2023/03/31

    More details Close

    高齢者の骨粗鬆症では、大脳楔前部の灰白質体積と、大腿骨頚部の骨密度に有意な正の相関を示すことが、研究代表者らの予備検討で確認されている。これは、アルツハイマー病でも体積に変化のみられる領域である。骨密度は骨折リスクを評価する臨床では標準的な指標であるが、骨密度が高くても骨質が良好でなければ、骨折リスクは高い。骨密度は、Dual-Energy X-ray Absorptmetry (DXA)を用いて計測している。しかしDXAでは骨質の評価は困難である。骨質を評価するため、東北大学病院加齢・老年病科の外来を受診した、フレイルまたは軽度認知機能障害の高齢者を対象に、骨粗鬆症、認知症の双方のバイオマーカーとされている血清ホモシステインなどのマーカーや、各被験者の運動歴などのデータを取得。フレイルは、J-CHS基準を用いて、筋力低下や歩行速度などを含めて評価。歩行機能については、携帯型3次元歩行分析計を用いて、歩行動作と歩行パターンの評価を行った。認知機能については、心理検査としてMMSEとMOCA-Jによる簡易スクリーニングを行った。脳画像は、3-T Philips Intera Achieca scannerを用いて、3次元形態画像（MPRAGE）による脳・筋繊維容積、PADRE（アミロイド/ヘム位相差強調画像）、デフォルトモード・ネットワーク、繊維走行および結合（DTI-FA)などの最新のパルスシーケンスを用いた。解析は、骨格筋量と骨塩量から、認知機能に影響を及ぼす早期バイオマーカーを分析し、DXAでは得られない骨質を評価するバイオマーカーの可能性を探る。また、脳と骨密度との関連を仲介している可能性のあるバイオマーカーの分析を進める。