Details of the Researcher

PHOTO

Peng Chen
Section
Graduate School of Dentistry
Job title
Associate Professor
Degree

  • Doctor of Engineering (Waseda University)

Researcher ID
AAU-9068-2021
Profile

Dr. Peng Chen is an Associate Professor at the Graduate School of Dentistry, Tohoku University, Japan. He received his Ph.D. through the Waseda–NIMS Joint Graduate Program in 2013 and subsequently joined the Institute of Biomaterials and Bioengineering at Tokyo Medical and Dental University. In 2023, he moved to Tohoku University. His research focuses on bioactive metallic materials, multiscale surface engineering, antibacterial biomaterials, material–cell interactions, and smart biointerfaces for dental and biomedical implants. Outside of research, he enjoys music, swimming, marathon running, and outdoor activities.

Research History 6

  • 2026/07 - Present
    Tohoku University　Graduate School of Dentistry　Associate Professor

  • 2025/09 - 2026/06
    Tohoku University　Graduate School of Dentistry　Senior Assistant Professor

  • 2023/04 - 2025/08
    Tohoku University　Graduate School of Dentistry　Assistant Professor

  • 2019/05 - 2023/04
    Tokyo Medical and Dental University(TMDU)　Institute of Biomaterials and Bioengineering　Assistant Professor

  • 2013/04 - 2019/04
    Tokyo Medical and Dental University(TMDU)　Institute of Biomaterials and Bioengineering　Specially Appointed Assistant Professor (Full time)

  • 2009/09 - 2010/02
    Inha University (Korea)　Industry-Academia Collaboration Research Institute　Research Assistant

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Education 3

  • Waseda University (Japan)　Graduate School of Advanced Science and Engineering　Department of Nanoscience and Nanoengineering

    2010/04 - 2013/03

  • Inha University (Korea)　Graduate School of Science and Engineering　Department of Polymer Science and Engineering

    2007/08 - 2009/07

  • Xiamen University (China)　Faculty of Science and Engineering　Department of Chemistry and Chemical Engineering

    2003/09 - 2007/07

Committee Memberships 7

  • Materials Transactions　Editorial Committee of the Japan Institute of Metals and Materials

    2026/04 - Present

  • The Japan Institute of Metals and Materials (JIM)　Editorial Committee Member of the "Materia"

    2025/04 - Present

  • Oral Biology Research　Editorial Board Member

    2025/04 - Present

  • the journal of Materials Chemistry and Physics, ELSEVIER SCIENCE SA　Editorial Board Member

    2024/10 - Present

  • the journal of Bioactive Materials, KEAI PUBLISHING LTD　Editorial Board Member

    2024/07 - Present

  • The Open Dentistry Journal, BENTHAM SCIENCE　Editorial Board Member

    2025/08 - Present

  • the Journal of Current Dentistry, BENTHAM SCIENCE　Editorial Board Member

    2023/10 - 2025/07

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Professional Memberships 8

  • Japanese Orthodontic Society

  • Japanese Society of Oral Implantology (JSOI)

  • THE JAPAN INSTITUTE OF METALS AND MATERIALS

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

  • THE JAPANESE SOCIETY FOR DENTAL MATERIALS AND DEVICES

  • Nano Biomedical Society

    2024/02 - Present

  • The Japanese Institute of Additive Manufacturing

    - Present

  • American Chemical Society (ACS)

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Research Interests 7

  • Cell-material interaction

  • Nanomanufacturing

  • Nanocytotoxicology

  • Cell-materials interface

  • Nanobioscience

  • Biomaterials

  • Ti and its alloys

Research Areas 5

  • Nanotechnology/Materials / Thin-film surfaces and interfaces /

  • Life sciences / Regenerative dentistry and dental engineering /

  • Nanotechnology/Materials / Nanobioscience /

  • Life sciences / Biomaterials /

  • Life sciences / Biomedical engineering /

Awards 36

  1. 論文発表奨励賞

    2026/01　レーザー学会第46回年次大会　歯科インプラント高機能化のための青色半導体レーザーマルチビーム金属堆積法によるチタン上への純銅コーティング

  2. ICALEO2025 Student Paper Award 2nd Place

    2025/10　The 44th annual International Congress on Applications of Lasers & Electro-Optics (ICALEO 2025)

  3. Poster Award 1st Place

    2024/11　The 43rd annual International Congress on Applications of Lasers & Electro-Optics (ICALEO 2024)

  4. Best Poster Award

    2023/11　TACT 2023 International Thin Film Conference　Evaluation of Osteogenic Properties of Bioactive Porous Titanium for Orthodontic Applications

  5. 優秀講演賞

    2023/03　表面技術協会第146回講演大会

  6. 優秀ポスター発表賞

    2021/11　日本バイオマテリアル学会 第43 回日本バイオマテリアル学会大会

  7. 株式会社ジーシー賞

    2021/10　日本歯科理工学会 第78 回日本歯科理工学会学術講演会

  8. 優秀ポスター賞

    2021/09　日本金属学会2021 年秋期（第169回）講演大会

  9. 奨励賞

    2021/03　表面技術協会第143回講演大会学術講演

  10. 優秀ポスター賞

    2020/12　日本金属学会第3回第7分野講演会

  11. 最優秀ポスター賞

    2020/12　日本金属学会第3回第7分野講演会

  12. 優秀ポスター賞

    2020/12　日本金属学会第3回第7分野講演会

  13. 優秀ポスター賞

    2019/12　日本金属学会第2回第7分野研究会

  14. 優秀ポスター賞

    2019/12　日本金属学会第2回第7分野研究会

  15. 最優秀ポスター賞

    2019/12　日本金属学会第2回第7分野研究会

  16. 最優秀ポスター賞

    2019/12　日本金属学会第2回第7分野研究会

  17. Outstanding Presentation Award

    2019/11　International Conterence on Materials and Systems for Sustainabllity (ICMaSS) 2019

  18. 優秀研究ポスター賞

    2019/11　第41回日本バイオマテリアル学会大会

  19. 若手講演奨励賞

    2019/10　腐食防食学会 第66回材料と環境討論会

  20. 優秀ポスター賞

    2019/09　日本金属学会日本金属学会2019年秋期(第165回)講演大会

  21. 最優秀ポスター賞

    2018/10　日本金属学会第1回第4分野講演会

  22. 学術奨励講演賞

    2018/03　表面技術協会第137回講演大会

  23. 優秀研究ポスター賞

    2017/11　日本バイオマテリアル学会

  24. Encouragement Presentation Award

    2017/09　2nd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development

  25. 高木賞

    2016/01　未踏科学技術協会

  26. 第16回優秀講演賞

    2015/03　表面技術協会

  27. 高木賞

    2015/01　未踏科学技術協会

  28. 高木賞

    2014/01　未踏科学技術協会

  29. ハイライト講演

    2013/11　第35回日本バイオマテリアル学会大会

  30. Award for Encouragement of Research in Materials Symposium A-8

    2012/09　The Materials Research Society of Japan

  31. Cultivating Young Scientists in Doctoral Course

    2012/08　Waseda University

  32. Excellent Young Student Researchers

    2012/01　The Society of Non-Traditional Technology

  33. Best Presentation

    2011/09　UCAM/NIMS/UCLA Summer School

  34. Cultivating Young Scientists in Doctoral Course

    2011/08　Waseda University

  35. Cultivating Young Scientists in Doctoral Course

    2010/08　Waseda University

  36. Poster Presentation Award

    Scientific Annual Meeting of ADEAP & CA+inD International Symposium 2024

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Papers 104

  1. Pure Copper Coating Layer Formation via Uniform Heating of Metal Powders and Substrates Using Multi-Beam Metal Powder Deposition with Rectangular Profile Blue Diode Lasers

    Keisuke Takenaka, Yuji Sato, Peng Chen, Takayuki Mokudai, Hiroyasu Kanetaka, Masahiro Tsukamoto

    International Journal of Automation Technology　2026/09/05

    DOI： 10.20965/ijat.2026.p0411 　

  2. Fluorescence Behavior of Octacalcium Phosphate Incorporating 3,5-Pyridinedicarboxylate Ions in Solutions of Different pH

    Jiansheng Fu, Masaya Shimabukuro, Taishi Yokoi, Peng Chen, Masakazu Kawashita

    Inorganic Chemistry　2026/08/24

    DOI： 10.1021/acs.inorgchem.6c01785 　

  3. Surface Activation of Zirconia Orthodontic Brackets by Multi-Gas Atmospheric Plasma: Effects on Shear Bond Strength

    Ryota Okubo, Peng Chen, Taiki Osawa, Akitoshi Okino, Hiroyasu Kanetaka

    Materials　2026/08/22

    DOI： 10.3390/ma19173564 　

  4. Ganoderma Microsporum immunomodulatory protein suppresses osteosarcoma growth through redox imbalance and ER stress-driven apoptosis Peer-reviewed

    Ying-Sui Sun, Chi-Jen Chang, Tsung-Ming Chang, Peng Chen, Ju-Fang Liu

    Bioorganic Chemistry　177　109909-109909　2026/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.bioorg.2026.109909 　

    ISSN： 0045-2068

  5. Hierarchical Surface Engineering Strategies for Next-Generation Dental Biomaterials Invited Peer-reviewed

    Peng Chen, Taishi Yokoi, Hiroyasu Kanetaka

    CERAMICS JAPAN　61　2026/08

  6. CXCL10 as a migration-associated biomarker in oral squamous cell carcinoma Peer-reviewed

    Ying-Sui Sun, Chi-Jen Chang, Tsung-Ming Chang, Peng Chen, Ju-Fang Liu

    BMC Oral Health　26　(1)　2026/04/14

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/s12903-026-08337-z 　

    eISSN： 1472-6831

  7. A Putative Hsa-miR-582-5p–CD81 Relationship Identified by Integrative Transcriptomic Analysis in Osteosarcoma

    Ju-Fang Liu, Tsung-Ming Chang, Chi-Jen Chang, Peng Chen, Ying-Sui Sun

    International Journal of Molecular Sciences　2026/02/05

    DOI： 10.3390/ijms27031558 　

  8. Synthesis of octacalcium phosphate with incorporated 1,4,5,8-naphthalenetetracarboxylate ions Peer-reviewed

    Taishi Yokoi, Mio Yoshizaki, Masaya Shimabukuro, Peng Chen, Kazuhiko Noda, Masakazu Kawashita

    Dalton Transactions　22　(9)　259-266　2026/02

    DOI： 10.1039/D5DT02854J 　

  9. Multibeam laser metal deposition of pure copper on a titanium substrate with blue diode lasers for surface functionalization of dental implants

    Tamaki Yoshida, Keisuke Takenaka, Yuji Sato, Peng Chen, Takayuki Mokudai, Hiroyasu Kanetaka, Masahiro Tsukamoto

    Journal of Laser Applications　2026/02/01

    DOI： 10.2351/7.0001956 　

  10. Emerging Metal Additive Manufacturing for Individualized Dental Therapies: A Narrative Review

    Peng Chen, Taishi Yokoi, Ying-Sui Sun, Huiyong Yang, Hiroyasu Kanetaka

    Dentistry Journal　2025/09/15

    DOI： 10.3390/dj13090424 　

  11. Recent Advances in Octacalcium Phosphate with Incorporated Carboxylate Ions: A Review

    Taishi Yokoi, Peng Chen, Masahiro Watanabe, Masakazu Kawashita

    Molecules　2025/08/27

    DOI： 10.3390/molecules30173508 　

  12. Physicochemical properties and cellular compatibility of calcium phosphate/pyrolytic carbon composites for artificial bone applications

    Peng Chen, Soichiro Usuki, Karen Kuroyama, Tomoyo Goto, Tohru Sekino, Hiroyasu Kanetaka, Tomoka Hasegawa, Masakazu Kawashita, Tetsuya Yoda, Taishi Yokoi

    JOURNAL OF ASIAN CERAMIC SOCIETIES　13　(3)　259-266　2025/07/03

    DOI： 10.1080/21870764.2025.2543128 　

    ISSN： 2187-0764

  13. Development of Zirconia/Calcium Phosphate/Pyrolytic Carbon Composites with Nanoscale Lamellar-Structured Grain Boundary Phases to Control Crack Propagation for Biomedical Applications

    Taishi Yokoi, Peng Chen, Kaname Yoshida, Yeongjun Seo, Tomoyo Goto, Karen Kuroyama, Tohru Sekino, Tomoka Hasegawa, Tetsuya Yoda, Hiroyasu Kanetaka, Masakazu Kawashita

    ACS Applied Nano Materials　8　(14)　7039-7048　2025/04/02

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsanm.5c00179 　

    ISSN： 2574-0970

    eISSN： 2574-0970

  14. Formation of Periodic Nanostructures on Medical Polymer with Femtosecond Laser for Control of Cell Spreading Peer-reviewed

    Keisuke Takenaka, Peng Chen, Yuji Sato, Masahiro Tsukmaoto

    Journal of Laser Micro/Nanoengineering　13　(3)　204　2024/12

    Publisher: Japan Laser Processing Society

    DOI： 10.2961/jlmn.2024.03.2005 　

    eISSN： 1880-0688

  15. Creating an extracellular matrix-like three-dimension structure to enhance the corrosion resistance and biological responses of titanium implants

    Ying-Sui Sun, Her-Hsiung Huang, Yi-Hsuan Tsai, Yu-Lin Kuo, Jyh-Wei Lee, Yun-Jung Lee, Thu Ya Linn, Peng Chen

    Journal of Dental Sciences　2024/12

    DOI： 10.1016/j.jds.2024.09.007 　

  16. Laser additive manufacturing of a carbon-supersaturated β-Ti alloy for biomaterial application

    Mingqi Dong, Yu Zhang, Weiwei Zhou, Peng Chen, Zhenxing Zhou, Hiroyasu Kanetaka, Takuya Ishimoto, Yuichiro Koizumi, Takayoshi Nakano, Naoyuki Nomura

    Additive Manufacturing Letters　11　2024/12

    DOI： 10.1016/j.addlet.2024.100233 　

    eISSN： 2772-3690

  17. Corrosion behavior of Zr-14Nb-5Ta-1Mo alloy in simulated body fluid

    Tomoyo MANAKA, Yusuke TSUTSUMI, Maki ASHIDA, Peng CHEN, Takao HANAWA

    Dental Materials Journal　43　(6)　755-761　2024/11/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2024-158 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  18. Enhancing Titanium Osteoconductivity by Alkali-Hot Water Treatment. International-journal

    Li Chang, Peng Chen, Takayuki Mokudai, Masakazu Kawashita, Itaru Mizoguchi, Hiroyasu Kanetaka

    ACS omega　9　(44)　44568-44576　2024/11/05

    DOI： 10.1021/acsomega.4c06702 　

    More details Close

    Titanium and its alloys are essential in orthopedic and dental treatments owing to their high strength, corrosion resistance, and superior biocompatibility compared with those of other metals. However, titanium alloys are bioinert. Previous studies have indicated that alkali treatment (AT) is a straightforward method to create a surface oxidization layer on titanium, thereby improving its bioactivity. Herein, alkali-hot water pretreatment was used to enhance the osteoconductivity of titanium and to identify a simple and efficient means of enhancing the interaction between osteoblasts and implants for clinical applications. Commercial pure titanium plates were ground (CP Ti) and subjected to alkali solution and hot water treatments (AWT). Single-process CP Ti specimens were prepared via either AT or hot water treatment (WT). Network-like structural features were observed in the AT specimens and were further refined and densified in the AWT specimens. Water contact angle testing revealed that the hydrophilicity of the titanium specimen (80° for CP Ti) increased by 19° for the AT specimens but decreased by 59° for the AWT specimens. Mouse preosteoblasts (MC3T3-E1 cells) were used for in vitro evaluation. After 24 h of culturing, the number of attached MC3T3-E1 cells on the AWT specimens was 1.5 times larger than that on the CP Ti specimens, suggesting that the alkali-hot water treatment enhanced the initial cell attachment. Cell proliferation evaluation indicated that fewer cells were detected in the AT and AWT specimens compared with those in the CP Ti or WT specimens. However, osteogenic differentiation evaluation on day 10 revealed a 1.5-fold higher alkaline phosphatase expression in cells cultured on the AWT specimens than in cells cultured on the CP Ti specimens. These findings demonstrate the good cytocompatibility and osteoconductivity of AWT Ti, highlighting its benefits in orthopedics and dental treatments.

  19. Pure copper coating by multibeam directed energy deposition with blue lasers for antimicrobial effect

    Tamaki Yoshida, Yuji Sato, Keisuke Takenaka, Peng Chen, Hiroyasu Kanetaka, Takayuki Mokudai, Masahiro Tsukamoto

    Journal of Laser Applications　2024/11/01

    DOI： 10.2351/7.0001588 　

  20. LaMer-model-based synthesis method for fine particles of octacalcium phosphate and related functional compounds

    Taishi Yokoi, Tomoyo Goto, Tohru Sekino, Tomoka Hasegawa, Peng Chen, Hiroyasu Kanetaka, Kaname Yoshida, Masaya Shimabukuro, Masakazu Kawashita

    CrystEngComm　2024

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4ce00663a 　

    eISSN： 1466-8033

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    We developed a new precipitation method based on the LaMer model for synthesising fine particles of plain octacalcium phosphate (OCP) and OCP with incorporated carboxylate ions.

  21. Galvanic Corrosion among Ti–6Al–4V ELI Alloy, Co–Cr–Mo Alloy, 316L-Type Stainless Steel, and Zr–1Mo Alloy for Orthopedic Implants

    Tomoyo Manaka, Yusuke Tsutsumi, Yukyo Takada, Peng Chen, Maki Ashida, Kotaro Doi, Hideki Katayama, Takao Hanawa

    Journal of the Japan Institute of Metals and Materials　2024

    Publisher: Japan Institute of Metals

    DOI： 10.2320/jinstmet.jc202404 　

    ISSN： 0021-4876

    eISSN： 1880-6880 2433-7501

  22. Lithium-Modified TiO2 Surface by Anodization for Enhanced Protein Adsorption and Cell Adhesion Peer-reviewed

    Huaze Wu, Takeshi Ueno, Kosuke Nozaki, Huichuan Xu, Yuki Nakano, Peng Chen, Noriyuki Wakabayashi

    ACS Applied Materials & Interfaces　15　(48)　55232-55243　2023/11/28

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsami.3c06749 　

    ISSN： 1944-8244

    eISSN： 1944-8252

  23. Development of bioinspired damage-tolerant calcium phosphate bulk materials

    Karen Kuroyama, Ryuichi Fujikawa, Tomoyo Goto, Tohru Sekino, Fumiya Nakamura, Hiromi Kimura-Suda, Peng Chen, Hiroyasu Kanetaka, Tomoka Hasegawa, Kaname Yoshida, Masaru Murata, Hidemi Nakata, Masaya Shimabukuro, Masakazu Kawashita, Tetsuya Yoda, Taishi Yokoi

    Science and Technology of Advanced Materials　24　(1)　2023/10/12

    Publisher: Informa UK Limited

    DOI： 10.1080/14686996.2023.2261836 　

    ISSN： 1468-6996

    eISSN： 1878-5514

  24. Effect of ultraviolet irradiation treatment on shear bond strength between polymethyl methacrylate and cobalt-chromium-molybdenum alloy Peer-reviewed

    San Win THANT, Atsushi TAKAICHI, Yuka KAJIMA, Amr MOHAMED, Kosuke NOZAKI, Hidekazu TAKAHASHI, Peng CHEN, Takao HANAWA, Noriyuki WAKABAYASHI

    Dental Materials Journal　42　(5)　748-755　2023/09/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2023-058 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  25. Development of a Surface Treatment to Achieve Long-Lasting Antimicrobial Properties and Non-Cytotoxicity through Simultaneous Incorporation of Ag and Zn via Two-Step Micro-Arc Oxidation

    Yusuke Tsutsumi, Harumi Tsutsumi, Tomoyo Manaka, Peng Chen, Maki Ashida, Hideki Katayama, Takao Hanawa

    COATINGS　13　(3)　2023/03

    DOI： 10.3390/coatings13030627 　

    eISSN： 2079-6412

  26. Galvanic Corrosion among Ti-6Al-4V ELI Alloy, Co-Cr-Mo Alloy, 316L-Type Stainless Steel, and Zr-1Mo Alloy for Orthopedic Implants br

    Tomoyo Manaka, Yusuke Tsutsumi, Yukyo Takada, Peng Chen, Maki Ashida, Kotaro Doi, Hideki Katayama, Takao Hanawa

    MATERIALS TRANSACTIONS　64　(1)　131-137　2023

    DOI： 10.2320/matertrans.MT-MLA2022001 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  27. Fabrication of micro-/submicro-/nanostructured surfaces on Ti–Zr alloy by varying H2SO4/H2O2 treatment conditions and investigations of fundamental properties of a typical surface

    Zhao, Q., Ueno, T., Chen, P., Nozaki, K., Tan, T., Hanawa, T., Wakabayashi, N.

    Surfaces and Interfaces　34　2022/11

    DOI： 10.1016/j.surfin.2022.102390 　

    ISSN： 2468-0230

  28. Galvanic Corrosion among Ti-6Al-4V ELI Alloy, Co-Cr-Mo Alloy, 316L-Type Stainless Steel, and Zr-1Mo Alloy for Orthopedic Implants

    Tomoyo Manaka, Yusuke Tsutsumi, Yukyo Takada, Peng Chen, Maki Ashida, Kotaro Doi, Hideki Katayama, Takao Hanawa

    MATERIALS TRANSACTIONS　2022/09

    DOI： 10.2320/matertrans.MT-MLA2022001] 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  29. X‐ray photoelectron spectroscopy‐based valence band spectra of passive films on titanium

    Yuzuki Eda, Tomoyo Manaka, Takao Hanawa, Peng Chen, Maki Ashida, Kazuhiko Noda

    Surface and Interface Analysis　54　(8)　892-898　2022/08

    Publisher: Wiley

    DOI： 10.1002/sia.7102 　

    ISSN： 0142-2421

    eISSN： 1096-9918

  30. Developing Microstructure and Enhancing Strength of Ti–6Al–7Nb Alloy with Heat Treatment Processed by High-Pressure Torsion

    Maki Ashida, Minami Hanai, Peng Chen, Takao Hanawa

    MATERIALS TRANSACTIONS　63　(6)　948-956　2022/06/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/matertrans.mt-m2021242 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  31. Evaluation of cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy with MC3T3-E1 cells

    Hiromitsu SATO, Peng CHEN, Maki ASHIDA, Yusuke TSUTSUMI, Hiroyuki HARADA, Takao HANAWA

    Dental Materials Journal　41　(3)　421-428　2022/05/25

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2021-169 　

    ISSN： 0287-4547

    eISSN： 1881-1361

  32. Surface properties and biocompatibility of sandblasted and acid-etched titanium–zirconium binary alloys with various compositions

    Tan, T., Zhao, Q., Kuwae, H., Ueno, T., Chen, P., Tsutsumi, Y., Mizuno, J., Hanawa, T., Wakabayashi, N.

    Dental Materials Journal　41　(2)　2022

    DOI： 10.4012/dmj.2021-210 　

    ISSN： 0287-4547 1881-1361

  33. Calcium Carbonate/Hydroxyapatite Microparticles and Osteoblast Responses

    Bergara-Muguruza, L., Abdelrazik, H.E., Chen, P., Ashida, M., Hanawa, T., Vallittu, P., Nakamura, M.

    Solid State Phenomena　340　2022

    DOI： 10.4028/p-06ymbz 　

    ISSN： 1012-0394 1662-9779

  34. Development of Electrochemical Surface Treatment to Visualize Critical Corrosion-Inducing Inclusions of Zr in Chloride Environments

    Tomoyo Manaka, Yusuke Tsutsumi, Peng Chen, Maki Ashida, Hideki Katayama, Takao Hanawa

    Journal of The Electrochemical Society　168　(12)　121505-121505　2021/12/01

    Publisher: The Electrochemical Society

    DOI： 10.1149/1945-7111/ac3ff1 　

    ISSN： 0013-4651

    eISSN： 1945-7111

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    An electrochemical surface treatment was developed to visualize the corrosion-inducing inclusions of Zr in chloride environments. Pure Zr and Zr alloy (Zr–0.5O–0.5C) were evaluated in this study. The electrochemical surface treatment consisted of repeated galvanostatic anodic polarization and potentiostatic cathodic polarization. After the electrochemical surface treatment, only one brittle and non-conductive shell of Zr oxide was observed at the corrosion initiation site on the tested surface. The corrosion-inducing inclusions were found inside the corrosion pit under the optimum polarization conditions. At the corrosion initiation site on pure Zr, the area inside the corrosion pit contained larger amounts of O, C, and Si than the surrounding matrix. In the case of the Zr-0.5O–0.5C alloy, relatively larger inclusions were observed after the treatment. Extremely large amounts of Si, together with O and C, were present in the inclusions. The inclusions that induced localized corrosion on the pure Zr and Zr-0.5O–0.5C specimens were found to be precipitated, involving the specific aggregation of Si. The surface treatment developed in this study is expected to be utilized as a powerful tool to elucidate the localized corrosion mechanism of Zr in chloride environments.

  35. Crystallographic texture- and grain boundary density-independent improvement of corrosion resistance in austenitic 316L stainless steel fabricated via laser powder bed fusion

    Yusuke Tsutsumi, Takuya Ishimoto, Tastuya Oishi, Tomoyo Manaka, Peng Chen, Maki Ashida, Kotaro Doi, Hideki Katayama, Takao Hanawa, Takayoshi Nakano

    Additive Manufacturing　45　2021/09

    DOI： 10.1016/j.addma.2021.102066 　

    eISSN： 2214-8604

  36. Corrosion Behavior and Bacterial Viability on Different Surface States of Copper

    Masaya Shimabukuro, Tomoyo Manaka, Yusuke Tsutsumi, Kosuke Nozaki, Chen Peng, Maki Ashida, Akiko Nagai, Takao Hanawa

    Zairyo-to-Kankyo　70　(8)　265-270　2021/08/10

    Publisher: Japan Society of Corrosion Engineering

    DOI： 10.3323/jcorr.70.265 　

    ISSN： 0917-0480

    eISSN： 1881-9664

  37. Investigation of the Long-Term Antibacterial Properties of Titanium by Two-Step Micro-Arc Oxidation Treatment

    Harumi Tsutsumi, Yusuke Tsutsumi, Masaya Shimabukuro, Tomoyo Manaka, Peng Chen, Maki Ashida, Kunio Ishikawa, Hideki Katayama, Takao Hanawa

    Coatings　11　(7)　798-798　2021/07/01

    Publisher: MDPI AG

    DOI： 10.3390/coatings11070798 　

    eISSN： 2079-6412

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    Recently, biofilm formation caused by bacterial adhesion and colonization has been recognized as the major cause of failure in orthopedic and dental implant surgeries. In this study, a customized micro-arc oxidation (MAO) treatment technique was developed to obtain desirable antibacterial properties on Ti surfaces. The two-step MAO treatment was applied in the fabrication of specimens with Ag and with/without Zn in their surface oxide layer. In order to simulate practical usage, surface analyses and immersion tests were performed to evaluate the incorporation of Ag and Zn into the resulting oxide layer and ion release behavior, respectively. Additionally, the antibacterial properties of the specimens after long-term immersion in physiological saline were evaluated using Gram-negative facultative anaerobic bacteria. The MAO-treated specimens containing Ag and Zn exhibited excellent antibacterial properties against Escherichia coli, which were sustained even after 6 months of immersion in physiological saline to simulate practical usage. Moreover, the Ag ions released from the surface oxide indicate the antibacterial properties of the specimen in the early stage, while the release of the corrosion products of Zn demonstrates its antibacterial properties in the later stage.

  38. Enhancement of antibacterial property of titanium by two-step micro arc oxidation treatment.

    Masaya Shimabukuro, Harumi Tsutsumi, Yusuke Tsutsumi, Tomoyo Manaka, Peng Chen, Maki Ashida, Kunio Ishikawa, Hideki Katayama, Takao Hanawa

    Dental materials journal　40　(3)　592-598　2021/05/29

    DOI： 10.4012/dmj.2020-188 　

    More details Close

    A customized micro arc oxidation (MAO) treatment technique was developed to obtain desirable antibacterial properties on titanium surfaces. The two-step MAO treatment was applied to fabricate a specimen containing both Ag and Zn in its surface oxide layer. Surface analyses and metal-ion release tests were performed to evaluate the presence of Ag and Zn and the ion release behavior for simulating practical usage, respectively. Additionally, the antibacterial properties of the specimens were also evaluated using gram-negative facultative anaerobic bacteria. The MAO-treated specimens containing both Ag and Zn showed excellent antibacterial properties against Escherichia coli, and the properties were sustained even after 28 days of immersion in physiological saline to simulate the living environment.

  39. Time Transient of Calcium and Phosphate Ion Adsorption by Rutile Crystal Facets in Hanks’ Solution Characterized by XPS

    Akari Hiji, Takao Hanawa, Taishi Yokoi, Peng Chen, Maki Ashida, Masakazu Kawashita

    Langmuir　37　(12)　3597-3604　2021/03/30

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.langmuir.0c03540 　

    ISSN： 0743-7463

    eISSN： 1520-5827

  40. Development of Electrochemical Surface Treatment for Improvement of Localized Corrosion Resistance of Zirconium in Chloride Environment

    Tomoyo Manaka, Yusuke Tsutsumi, Maki Ashida, Peng Chen, Hideki Katayama, Takao Hanawa

    MATERIALS TRANSACTIONS　62　(6)　788-796　2021

    DOI： 10.2320/matertrans.C-M2021817 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  41. Development of Electrochemical Surface Treatment for Improvement of Localized Corrosion Resistance of Zirconium in Chloride Environment

    Tomoyo Manaka, Yusuke Tsutsumi, Maki Ashida, Peng Chen, Hideki Katayama, Takao Hanawa

    Zairyo-to-Kankyo　69　(11)　307-314　2020/11/10

    Publisher: Japan Society of Corrosion Engineering

    DOI： 10.3323/jcorr.69.307 　

    ISSN： 0917-0480

    eISSN： 1881-9664

  42. Effect of Impurity Elements on Localized Corrosion of Zirconium in Chloride Containing Environment

    Yusuke Tsutsumi, Izumi Muto, Shigeyuki Nakano, Junichi Tsukada, Tomoyo Manaka, Peng Chen, Maki Ashida, Yu Sugawara, Masayuki Shimojo, Nobuyoshi Hara, Hideki Katayama, Takao Hanawa

    Journal of The Electrochemical Society　167　(14)　141507-141507　2020/11/06

    Publisher: The Electrochemical Society

    DOI： 10.1149/1945-7111/abc5d8 　

    eISSN： 1945-7111

  43. Initial formation kinetics of calcium phosphate on titanium in Hanks' solution characterized using XPS

    Akari Hiji, Takao Hanawa, Masaya Shimabukuro, Peng Chen, Maki Ashida, Kunio Ishikawa

    Surface and Interface Analysis　2020/10/22

    Publisher: Wiley

    DOI： 10.1002/sia.6900 　

    ISSN： 0142-2421

    eISSN： 1096-9918

  44. Zirconium-based metallic glass and zirconia coatings to inhibit bone formation on titanium

    S Thanka Rajan, Anusha Thampi V V, Michiko Terada-Nakaishi, Peng Chen, Takao Hanawa, A K Nandakumar, B Subramanian

    Biomedical Materials　15　(6)　065019-065019　2020/10/13

    Publisher: IOP Publishing

    DOI： 10.1088/1748-605x/aba23a 　

    ISSN： 1748-6041

    eISSN： 1748-605X

    More details Close

    Abstract Surface-modified commercially pure titanium (Cp-Ti) with zirconium (Zr)-based thin film metallic glasses (Zr-TFMGs) and ZrO2 thin films were surgically implanted into the tibiae of rats; the bone formation was analyzed to examine the performance of the coatings as a biomaterial. Zr-TFMGs and ZrO2 thin films were coated on Cp-Ti substrates to monitor the control of assimilation in vitro and in vivo. The microstructural and elemental analyses were carried out for the as deposited thin films by x-ray diffraction (XRD), transmission electron microscopy and x-ray photoelectron spectroscopy. TFMG- and ZrO2-coated Ti specimens were immersed in simulated body fluid (SBF) for a period of 21 days to evaluate the calcium phosphate precipitation in vitro. XRD, x-ray photoelectron spectroscopy and scanning electron microscopy/energy dispersive x-ray spectroscopy were used to quantify the mineralization on the coated Zr-TFMG and ZrO2. In vitro corrosion studies showed that the Zr-based TFMG and ZrO2 coatings sustained in the SBF, exhibited superior corrosion resistance to the bare crystalline Ti substrate. Wettability studies showed TFMG and ZrO2 coatings with a hydrophobic nature, and the TFMG-coated SBF-submerged specimens showed a hydrophilic nature. The in vitro cell viability of MC3T3-E1 cells showed good cell proliferation and low cytotoxicity. The calcification deposits were evaluated by staining with alizarin red S, which showed a lower calcium formation on Zr-TFMG compared to ZrO2. The present work also aims to assess the assimilation behavior of Cp-Ti, Zr-TFMG and ZrO2in vivo by inserting the coated specimen in the femur of rats. After post-implantation of 8 weeks, specimens were examined by micro-CT evaluation. The bone contact ratios as calculated were 72.75%, 15.32% and 38.79%. Consequently, the bone affinity was Cp-Ti wire >ZrO2-coated Ti wire >Zr48Cu36Ag8Al8-coated Ti wire.

  45. Investigation of antibacterial effect of copper introduced titanium surface by electrochemical treatment against facultative anaerobic bacteria Peer-reviewed

    Shimabukuro, M., Tsutsumi, Y., Nozaki, K., Chen, P., Yamada, R., Ashida, M., Doi, H., Nagai, A., Hanawa, T.

    Dental Materials Journal　39　(4)　639-647　2020/07/30

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2019-178 　

    ISSN： 0287-4547 1881-1361

    eISSN： 1881-1361

  46. Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties Peer-reviewed

    Masaya Shimabukuro, Akari Hiji, Tomoyo Manaka, Kosuke Nozaki, Peng Chen, Maki Ashida, Yusuke Tsutsumi, Akiko Nagai, Takao Hanawa

    Journal of Functional Biomaterials　11　(2)　44-44　2020/06/22

    DOI： 10.3390/jfb11020044 　

    eISSN： 2079-4983

  47. Corrosion behavior and bacterial viability on different surface states of copper Peer-reviewed

    Masaya Shimabukuro, Tomoyo Manaka, Yusuke Tsutsumi, Kosuke Nozaki, Peng Chen, Maki Ashida, Akiko Nagai, Takao Hanawa

    MATERIALS TRANSACTIONS　61　(6)　1143-1148　2020/06/01

    DOI： 10.2320/matertrans.mt-m2020008 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  48. Design of zirconium quaternary system alloys and their properties Peer-reviewed

    Ashida, M., Tsutsumi, Y., Homma, K., Chen, P., Shimojo, M., Hanawa, T.

    Materials Transactions　61　(4)　776-781　2020/04/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/matertrans.MT-M2019315 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  49. Fatigue property and cytocompatibility of a biomedical Co-Cr-Mo alloy subjected to a high pressure torsion and a subsequent short time annealing Peer-reviewed

    Peng Chen, Huihong Liu, Mitsuo Niinomi, Zenji Horita, Hidetoshi Fujii, Takao Hanawa

    Materials Transactions　61　(2)　361-367　2020/01/25

  50. The change of surface charge by lithium ion coating enhances protein adsorption on titanium Peer-reviewed

    Isoshima K, Ueno T, Arai Y, Saito H, Chen P, Tsutsumi Y, Hanawa T, Wakabayashi N

    Journal of the Mechanical Behavior of Biomedical Materials　100　103393-103393　2019/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.jmbbm.2019.103393 　

    ISSN： 1751-6161

  51. Investigation of realizing both antibacterial property and osteogenic cell compatibility on titanium surface by simple electrochemical treatment Peer-reviewed

    Shimabukuro M, Tsutsumi Y, Yamada R, Ashida M, Chen P, Doi H, Nozaki K, Nagai A, Hanawa T

    ACS Biomaterials Science & Engineering　5　(11)　5623-5630　2019/11

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acsbiomaterials.8b01058 　

    ISSN： 2373-9878

    eISSN： 2373-9878

  52. The effects of various metallic surfaces on cellular and bacterial adhesion Peer-reviewed

    Shimabukuro, M., Ito, H., Tsutsumi, Y., Nozaki, K., Chen, P., Yamada, R., Ashida, M., Nagai, A., Hanawa, T.

    Metals　9　(11)　1145　2019/10

    DOI： 10.3390/met9111145 　

    ISSN： 2075-4701

  53. Chemical and biological roles of zinc in a porous titanium dioxide layer formed by micro-arc oxidation Peer-reviewed

    Shimabukuro M, Tsutsumi Y, Nozaki K, Chen P, Yamada R, Ashida M, Doi H, Nagai A, Hanawa T

    Coatings　9　(11)　705-705　2019/10

    Publisher: MDPI AG

    DOI： 10.3390/coatings9110705 　

    eISSN： 2079-6412

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    This study investigated the time transient effect of zinc (Zn) in the porous titanium dioxide formed by micro-arc oxidation (MAO) treatment routinely performed for Zn-containing electrolytes. The aim of our analysis was to understand the changes in both the chemical and biological properties of Zn in physiological saline. The morphology of the Zn-incorporated MAO surface did not change, and a small amount of Zn ions were released at early stages of incubation in saline. We observed a decrease in Zn concentration in the oxide layer because its release and chemical state (Zn2+ compound to ZnO) changed over time during incubation in saline. In addition, the antibacterial property of the Zn-incorporated MAO surface developed at late periods after the incubation process over a course of 28 days. Furthermore, osteogenic cells were able to proliferate and were calcified on the specimens with Zn. The changes related to Zn in saline had non-toxic effects on the osteogenic cells. In conclusion, the time transient effect of Zn in a porous titanium dioxide layer was beneficial to realize dual functions, namely the antibacterial property and osteogenic cell compatibility. Our study suggests the importance of the chemical state changes of Zn to control its chemical and biological properties.

  54. Surface characterization of commercially available yttria-stabilized tetragonal zirconia polycrystalline in water and Hanks’ solution using X-ray photoelectron spectroscopy Peer-reviewed

    Oishi, M., Tsutsumi, Y., Chen, P., Nakaishi, M., Ashida, M., Doi, H., Hanawa, T.

    Dental Materials Journal　38　(3)　496-504　2019/06

    DOI： 10.4012/dmj.2018-299 　

    ISSN： 0287-4547 1881-1361

  55. Promoted osteoconductivity of titanium with chessboard-patterned surface nano topography fabricated by femtosecond laser irradiation

    Peng Chen, Keisuke Takenaka, Masahiro Tsukamoto, Maki Ashida, Yusuke Tsutsumi, Hisashi Doi, Takao Hanawa

    Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium　40　355　2019

    ISSN： 1526-7547

  56. Adhesion and differentiation behaviors of mesenchymal stem cells on titanium with micrometer and nanometer-scale grid patterns produced by femtosecond laser irradiation Peer-reviewed

    Chen, P., Aso, T., Sasaki, R., Ashida, M., Tsutsumi, Y., Doi, H., Hanawa, T.

    Journal of Biomedical Materials Research Part A　106　(10)　2735-2743　2018/10

    DOI： 10.1002/jbm.a.36503 　

    ISSN： 1549-3296 1552-4965

  57. Inverse response of osteoblasts and fibroblasts to growth on carbon-deposited titanium surfaces Peer-reviewed

    Chie Yoshihara, Takeshi Ueno, Peng Chen, Yusuke Tsutsumi, Takao Hanawa, Noriyuki Wakabayashi

    Journal of Biomedical Materials Research - Part B Applied Biomaterials　106　(5)　1869-1877　2018/07/01

    Publisher: John Wiley and Sons Inc.

    DOI： 10.1002/jbm.b.33996 　

    ISSN： 1552-4981 1552-4973

  58. Effects of cold swaging on mechanical properties and magnetic susceptibility of the Zr–1Mo alloy Peer-reviewed

    Maki Ashida, Masahiro Morita, Yusuke Tsutsumi, Naoyuki Nomura, Hisashi Doi, Peng Chen, Takao Hanawa

    Metals　8　(6)　454　2018/06/13

    Publisher: MDPI AG

    DOI： 10.3390/met8060454 　

    ISSN： 2075-4701

  59. Surface changes of yttria-stabilized zirconia in water and Hanks solution characterized using XPS Peer-reviewed

    M. Oishi, Y. Tsutsumi, P. Chen, M. Ashida, H. Doi, T. Hanawa

    Surface and Interface Analysis　50　(5)　587-591　2018/05/01

    Publisher: John Wiley and Sons Ltd

    DOI： 10.1002/sia.6435 　

    ISSN： 1096-9918 0142-2421

  60. Response of preosteoblasts to titanium with periodic micro/nanometer scale grooves produced by femtosecond laser irradiation Peer-reviewed

    Peng Chen, Masayoshi Miyake, Masahiro Tsukamoto, Yusuke Tsutsumi, Takao Hanawa

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　105　(12)　3456-3464　2017/12

    DOI： 10.1002/jbm.a.36202 　

    ISSN： 1549-3296

    eISSN： 1552-4965

  61. Nanotechnology for intelligent surface designing of metallic dental implants Peer-reviewed

    Chen P, Homhuan P

    Journal of Science and Technology Phranakorn Si Ayuthaya Rajabhat　5　(1)　58-67　2017/06

  62. Micron/Submicron Hybrid Topography of Titanium Surfaces Influences Adhesion and Differentiation Behaviors of the Mesenchymal Stem Cells Peer-reviewed

    Peng Chen, Toshihiro Aso, Ryuichiro Sasaki, Yusuke Tsutsumi, Maki Ashida, Hisashi Doi, Takao Hanawa

    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY　13　(3)　324-336　2017/03

    DOI： 10.1166/jbn.2017.2335 　

    ISSN： 1550-7033

    eISSN： 1550-7041

  63. Dependence of Ti Plate Surface Morphology Varied by Femtosecond Laser Irradiation on Cell Spreading

    Masayoshi MIYAKE, Masahiro TSUKAMOTO, Yuji SATO, Takahiro OGA, Akiko NAGAI, Peng CHEN, Takao HANAWA

    The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-1)　2016/10

  64. Calcification of Preosteoblast on Nano Topography Fabricated by Femtosecond Laser

    Peng CHEN, Takuya KAWA, Masayoshi MIYAKE, Takahiro OOGA, Masahiro TSUKAMOTO, Maki ASHIDA, Yusuke TSUTSUMI, Hisashi DOI, Takao HANAWA

    The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-1)　2016/10

  65. Phospholipid polymer electrodeposited on titanium inhibits platelet adhesion Peer-reviewed

    Yusuke Fukuhara, Megumi Kyuzo, Yusuke Tsutsumi, Akiko Nagai, Peng Chen, Takao Hanawa

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　104　(3)　554-560　2016/04

    DOI： 10.1002/jbm.b.33423 　

    ISSN： 1552-4973

    eISSN： 1552-4981

  66. Electrochemical surface treatment of a β-titanium alloy to realize an antibacterial property and bioactivity Peer-reviewed

    Yusuke Tsutsumi, Mitsuo Niinomi, Masaaki Nakai, Masaya Shimabukuro, Maki Ashida, Peng Chen, Hisashi Doi, Takao Hanawa

    Metals　6　(4)　76　2016/03/28

    Publisher: MDPI AG

    DOI： 10.3390/met6040076 　

    ISSN： 2075-4701

  67. Differences in the calcification of preosteoblast cultured on sputter-deposited titanium, zirconium, and gold Peer-reviewed

    Peng Chen, Akiko Nagai, Yusuke Tsutsumi, Maki Ashida, Hisashi Doi, Takao Hanawa

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　104　(3)　639-651　2016/03

    DOI： 10.1002/jbm.a.35598 　

    ISSN： 1549-3296

    eISSN： 1552-4965

  68. Cell spreading on titanium periodic nanostructures with periods of 200, 300 and 600 nm produced by femtosecond laser irradiation Peer-reviewed

    M. Tsukamoto, T. Kawa, T. Shinonaga, P. Chen, A. Nagai, T. Hanawa

    APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING　122　(2)　120　2016/02

    DOI： 10.1007/s00339-016-9626-5 　

    ISSN： 0947-8396

    eISSN： 1432-0630

  69. Effect of strontium ions on calcification of preosteoblasts cultured on porous calcium-and phosphate-containing titanium oxide layers formed by micro-arc oxidation Peer-reviewed

    Mizuki Sato, Peng Chen, Yusuke Tsutsumi, Makoto Shiota, Takao Hanawa, Shohei Kasugai

    Dental Materials Journal　35　(4)　627-634　2016

    Publisher: Japanese Society for Dental Materials and Devices

    DOI： 10.4012/dmj.2016-032 　

    ISSN： 1881-1361 0287-4547

  70. Cytocompatibility of Ti-6Al-7Nb through High-Pressure Torsion Processing Peer-reviewed

    Peng Chen, Maki Ashida, Hisashi Doi, Yusuke Tsutsumi, Zenji Horita, Takao Hanawa

    MATERIALS TRANSACTIONS　57　(12)　2020-2025　2016

    DOI： 10.2320/matertrans.MI201515 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  71. Surface Composition and Corrosion Resistance of Co-Cr Alloys Containing High Chromium Peer-reviewed

    Yusuke Tsustumi, Hisashi Doi, Naoyuki. Nomura, Maki Ashida, Peng Chen, Akira K. Awasaki, Takao Hanawa

    MATERIALS TRANSACTIONS　57　(12)　2033-2040　2016

    DOI： 10.2320/matertrans.MI201514 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  72. Evaluation of release and accumulation of metal ions from titanium and nickel by accelerated dissolution test in simulated body environments Peer-reviewed

    Okamoto, H., Tsutsumi, Y., Watanabe, M., Yamakage, K., Ashida, M., Chen, P., Doi, H., Miura, H., Matsumura, M., Hanawa, T.

    Electrochemistry　83　(12)　1048-1052　2015/12

    DOI： 10.5796/electrochemistry.83.1048 　

    ISSN： 1344-3542 2186-2451

  73. Reaction of calcium and phosphate ions with titanium, zirconium, niobium, and tantalum Peer-reviewed

    Yusuke Tsutsumi, Takeru Nishisaka, Hisashi Doi, Maki Ashida, Peng Chen, Takao Hanawa

    SURFACE AND INTERFACE ANALYSIS　47　(13)　1148-1154　2015/12

    DOI： 10.1002/sia.5866 　

    ISSN： 0142-2421

    eISSN： 1096-9918

  74. Influence of microstructures formed by femtosecond laser ablationunder vacuum and air on cell spreading

    Masayoshi Miyake, Masahiro Tsukamoto, Yuji Sato, Takuya Kawa, Tetsuya Nakaaze, Akiko Nagai, Peng Chen, Takao Hanawa

    International Symposium on EcoTopia Science 2015（ISETS'15)　2015/11

  75. The cell spreading on Ti plate surface with microstructures formed by femtosecond and nanosecond lase

    Tetsuya Nakaaze, Masahiro Tsukamoto, Yuji Sato, Takuya Kawa, Masayoshi Miyake, Peng Chen, Akiko Nagai, Takao Hanawa

    International Symposium on EcoTopia Science 2015（ISETS'15)　2015/11

  76. The effect of different component ratios in block polymers and processing conditions on electrodeposition efficiency onto titanium Peer-reviewed

    Yusuke Fukuhara, Megumi Kyuzo, Yusuke Tsutsumi, Akiko Nagai, Peng Chen, Takao Hanawa

    APPLIED SURFACE SCIENCE　355　784-791　2015/11

    DOI： 10.1016/j.apsusc.2015.07.177 　

    ISSN： 0169-4332

    eISSN： 1873-5584

  77. Effect of periodic nanostructures produced with femtosecond laser for wavelength of 388 and 775 nm on cell spreading Peer-reviewed

    Togo Shinonaga, Masahiro Tsukamoto, Peng Chen, Takao Hanawa

    IEEJ Transactions on Fundamentals and Materials　135　(10)　587-591　2015/10/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejfms.135.587 　

    ISSN： 1347-5533 0385-4205

  78. 波長388nm及び775nmのフェムト秒レーザーにより形成した周期的微細構造が細胞伸展に与える効果 Peer-reviewed

    篠永東吾, 塚本雅裕, 陳 鵬, 塙 隆夫

    電気学会論文誌A　135　(10)　587-591　2015/10

  79. Calcification of MC3T3-E1 cells on titanium and zirconium Peer-reviewed

    Takayuki Umezawa, Peng Chen, Yusuke Tsutsumi, Hisashi Doi, Maki Ashida, Shoichi Suzuki, Keiji Moriyama, Takao Hanawa

    DENTAL MATERIALS JOURNAL　34　(5)　713-718　2015/10

    DOI： 10.4012/dmj.2015-018 　

    ISSN： 0287-4547

  80. Superplasticity in the Ti-6Al-7Nb alloy processed by high-pressure torsion Peer-reviewed

    Ashida, M., Chen, P., Doi, H., Tsutsumi, Y., Hanawa, T., Horita, Z.

    Materials Science and Engineering A　640　449-453　2015/06

    DOI： 10.1016/j.msea.2015.06.020 　

    ISSN： 0921-5093

  81. Formation of periodic nanostructures using a femtosecond laser to control cell spreading on titanium Peer-reviewed

    Shinonaga, T., Tsukamoto, M., Kawa, T., Chen, P., Nagai, A., Hanawa, T.

    Applied Physics B Lasers and Optics　119　(3)　493-496　2015/03

    DOI： 10.1007/s00340-015-6082-4 　

    ISSN： 0946-2171

  82. The effect of femtosecond laser induced periodic nano- and microstructures for cell spreading Peer-reviewed

    Nakaaze Tetsuya, Tsukamoto Masahiro, Shinonaga Togo, Sato Yuji, Kawa Takuya, Peng Chen, Nagai Akiko

    Preprints of the National Meeting of JWS　2015　(0)　146-147　2015

    Publisher: JAPAN WELDING SOCIETY

    DOI： 10.14920/jwstaikai.2015f.0_146 　

  83. Difference in preosteoblast calcification on sputter-deposited titanium and zirconium in vitro Invited

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    Annual reports of the Institute of Biomaterials and Bioengineering　49　3-6　2015

    Publisher:

    ISSN： 1345-2886

  84. Microstructure and mechanical properties of large-scale ingots of the Zr-1Mo alloy Peer-reviewed

    Maki Ashida, Tomohiro Sugimoto, Naoyuki Nomura, Yusuke Tsutsumi, Peng Chen, Hisashi Doi, Takao Hanawa

    Materials Transactions　56　(9)　1544-1548　2015

    Publisher: Japan Institute of Metals (JIM)

    DOI： 10.2320/matertrans.M2015098 　

    ISSN： 1345-9678

  85. Femtosecond laser induced periodic nanostructures and microstructures on Ti plate for control of cell spreading

    Kazuya Miyagawa, Masahiro Tsukamoto, Togo Shinonaga, Kazuyuki Hara, Peng Chen, Akiko Nagai, Takao Hanawa

    Proc. 33rd International Congress on Applications of Lasers & Electro-Optics(ICALEO 2014)　on line　2014/10

  86. ジルコニウムスパッタ蒸着チタンのMC3T3-E1細胞適合性

    梅澤峻之, 陳鵬, 堤祐介, 土居壽, 蘆田茉希, 鈴木聖一, 森山啓司, 塙隆夫

    日本歯科理工学会誌　33　(5)　471　2014/09

  87. Periodic Nanostructures Formation for Creating New Functional Biomaterials

    Togo Shinonaga, Masahiro Tsukamoto, Peng Chen, Akiko Nagai, Takao Hanawa

    第75回応用物理学会秋季学術講演会 OSA joint session　2014/09

  88. Formation of white oxide layer on Zr-14Nb alloy using thermal treatment Peer-reviewed

    Miao Yu, Hisashi Doi, Yusuke Tsutsumi, Peng Chen, Maki Ashida, Shohei Kasugai, Takao Hanawa

    DENTAL MATERIALS JOURNAL　33　(4)　490-498　2014/08

    DOI： 10.4012/dmj.2013-323 　

    ISSN： 0287-4547

  89. Microstructures and mechanical properties of Ti-6Al-7Nb processed by high-pressure torsion Peer-reviewed

    Maki Ashida, Peng Chen, Hisashi Doi, Yusuke Tsutsumi, Takao Hanawa, Zenji Horita

    11TH INTERNATIONAL CONFERENCE ON TECHNOLOGY OF PLASTICITY, ICTP 2014　81　1523-1528　2014

    DOI： 10.1016/j.proeng.2014.10.184 　

    ISSN： 1877-7058

  90. Improving biocompatibility of titanium by periodic nanostructure formation with femtosecond laser

    Yuichiro Ito, Masahiro Tsukamoto, Togo Shinonaga, Kazuya Miyagawa, Peng Chen, Akiko Nagai, Takao Hanawa

    ISETS 2013 and AMDI-4　2013/12

  91. Improving the Biocompatibility of TiO2 Film Formed and Modified with Aerosol Beam and Femtosecond Laser

    Togo Shinonaga, Masahiro Tsukamoto, Yuichiro Ito, Kazuya Miyagawa, Peng Chen, Akiko Nagai, Takao Hanawa

    ISETS 2013 and AMDI-4　2013/12

  92. Effects of periodic nanostructures formation produced with femtosecond laser on biocompatibility of Titanium dioxide film

    SHINONAGA Togo, ITO Yuichiro, TSUKAMOTO Masahiro, ABE Nobuyuki, CHEN Peng, NAGAI Akiko, HANAWA Takao, MATSUSHITA Nobuhiro, XIE GUOQIANG

    Preprints of the National Meeting of JWS　93　238-239　2013/08/12

    Publisher: JAPAN WELDING SOCIETY

    DOI： 10.14920/jwstaikai.2013f.0.238.0 　

  93. Role of toll-like receptors 3, 4 and 7 in cellular uptake and response to titanium dioxide nanoparticles Peer-reviewed

    Chen, P., Kanehira, K., Taniguchi, A.

    Science and Technology of Advanced Materials　14　(1)　15008　2013/03

    DOI： 10.1088/1468-6996/14/1/015008 　

    ISSN： 1468-6996

  94. Detection of cellular response to titanium dioxide nanoparticle agglomerates by sensor cells using heat shock protein promoter Peer-reviewed

    Peng Chen, Koki Kanehira, Shuji Sonezaki, Akiyoshi Taniguchi

    BIOTECHNOLOGY AND BIOENGINEERING　109　(12)　3112-3118　2012/12

    DOI： 10.1002/bit.24583 　

    ISSN： 0006-3592

  95. Detection of DNA damage response by different forms of titanium dioxide nanoparticles using sensor cells Peer-reviewed

    Chen P, Taniguchi A

    Biosens Bioelectron　3　(5)　129　2012/10

  96. Development of Sensor Cells Using NF-kappa B Pathway Activation for Detection of Nanoparticle-Induced Inflammation Peer-reviewed

    Peng Chen, Satoshi Migita, Koki Kanehira, Shuji Sonezaki, Akiyoshi Taniguchi

    SENSORS　11　(7)　7219-7230　2011/07

    DOI： 10.3390/s110707219 　

    ISSN： 1424-8220

  97. Modification and Applications of Bacterial Celluloses in Polymer Science Peer-reviewed

    Peng Chen, Se Youn Cho, Hyoung-Joon Jin

    MACROMOLECULAR RESEARCH　18　(4)　309-320　2010/04

    DOI： 10.1007/s13233-010-0404-5 　

    ISSN： 1598-5032

  98. Multiwalled Carbon Nanotubes-Embedded Electrospun Bacterial Cellulose Nanofibers Peer-reviewed

    Peng Chen, Young Soo Yun, Hyeonseong Bak, Se Youn Cho, Hyoung-Joon Jin

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS　519　(1)　169-178　2010

    DOI： 10.1080/15421401003613659 　

    ISSN： 1542-1406

  99. The effect of chitosan content on the crystallinity, thermal stability, and mechanical properties of bacterial cellulose-chitosan composites Peer-reviewed

    Cai, Z., Chen, P., Jin, H.-J., Kim, J.

    Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science　223　(10)　2225-2230　2009/06

    DOI： 10.1243/09544062JMES1480 　

    ISSN： 0954-4062

  100. Preparation, Properties and Application of Polyamide/Carbon Nanotube Nanocomposites Peer-reviewed

    Peng Chen, Hun-Sik Kim, Hyoung-Joon Jin

    MACROMOLECULAR RESEARCH　17　(4)　207-217　2009/04

    ISSN： 1598-5032

  101. Regenerated bacterial cellulose/multi-walled carbon nanotubes composite fibers prepared by wet-spinning Peer-reviewed

    Peng Chen, Hun-Sik Kim, Soon-Min Kwon, Young Soo Yun, Hyoung-Joon Jin

    CURRENT APPLIED PHYSICS　9　(2)　E96-E99　2009/03

    DOI： 10.1016/j.cap.2008.12.038 　

    ISSN： 1567-1739

  102. Preparation of multiwalled carbon nanotubes incorporated silk fibroin nanofibers by electrospinning Peer-reviewed

    Minsung Kang, Peng Chen, Hyoung-Joon Jin

    CURRENT APPLIED PHYSICS　9　(1)　S95-S97　2009/01

    DOI： 10.1016/j.cap.2008.08.014 　

    ISSN： 1567-1739

  103. Fluorescent silk fibroin nanoparticles prepared using a reverse microemulsion Peer-reviewed

    Myung, S.J., Kim, H.-S., Kim, Y., Chen, P., Jin, H.-J.

    Macromolecular Research　16　(7)　604-608　2008/08

    DOI： 10.1007/BF03218567 　

    ISSN： 1598-5032

  104. pH-triggered transition of silk fibroin from spherical micelles to nanofibrils in water Peer-reviewed

    Peng Chen, Hyun Suk Kim, Chi-Young Park, Hun-Sik Kim, In-Joo Chin, Hyoung-Joon Jin

    MACROMOLECULAR RESEARCH　16　(6)　539-543　2008/08

    ISSN： 1598-5032

Show all ︎Show first 5

Misc. 4

  1. Development of Ultrahigh Corrosion Resistant Metallic Materials ―Improvement of Corrosion Resistance of Martensitic Stainless Steel by Selective Laser Melting Process― Peer-reviewed

    Yusuke Tsutsumi, Takuya Ishimoto, Kyosuke Ueda, Shinpei Maruyama, Tetsuji Kuse, Aira Matsugaki, Maki Ashida, Peng Chen

    Materia Japan　59　(12)　679-684　2020/12/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/materia.59.679 　

    ISSN： 1340-2625

    eISSN： 1884-5843

  2. Variation of Cell Spreading on Titanium Dioxide Film by Periodic Nanostructures Formation with Femtosecond Laser

    Shinonaga Togo, Nagai Akiko, Hanawa Takao, Peng Chen, Tsukamoto Masahiro

    Transactions of JWRI　43　(2)　7-10　2014/12

    Publisher: Joining and Welding Research Institute, Osaka University

    ISSN： 0387-4508

  3. P-74 Corrosion resistance of high nitrogen inclusion Co-Cr-Mo-W alloy

    Doi H, Tsutsumi Y, Ashida M, Chen P, Nomura N, Hanawa T

    The journal of the Japanese Society for Dental Materials and Devices　33　(5)　479-479　2014/09/20

    Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)

    ISSN： 1884-4421

    More details Close

    The Co-Cr-Mo alloy is applied for dental casting alloy. This alloy though both mechanical properties, corrosion resistance are excellent, research and development in which in addition, the property is improved is advanced. In this study, mechanical properties and corrosion resistance were examined on the alloy which replaced Mo of Co-33Cr-5Mo-0.3N alloy in W. On The result showed that mechanical properties were improved, as the composition of W increases. And, though on the corrosion resistance, the improvement by addition of W was not observed, the lowering could not be observed either.

  4. PMSE 245-Thermogravimetric analysis of poly(L-lactide)/clay nanocomposites

    Hun-Sik Kim, Don-Young Kim, Yeseul Kim, Peng Chen, Yun Seok Chae, Jin-San Yoon, Hyoung-Joon Jin

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　236　2008/08

    ISSN： 0065-7727

Books and Other Publications 1

  1. Novel Structured Metallic and Inorganic Materials

    Chen P, Tsukamoto M

    Springer Nature Singapore　2019/09

Presentations 140

  1. 歯科用チタン材料における表面改質技術と生体適合性評価 Invited

    陳鵬

    第7回出島コンソーシアム・セミナー 「バイオ・医療機器材料の新展開」　2025/11/26

  2. Surface Engineering of Biomedical Metals with Laser Processing Invited

    Peng Chen

    2025 Fall Conference of The Corrosion Science Society of Korea (CSSK2025)　2025/11/14

  3. Smart Surface Functionalization of Titanium for Dual Antibacterial and Osteoconductive Functions Invited

    Peng Chen, Hiroyasu Kanetaka

    TACT2025 International Thin Film Conference　2025/10/27

  4. Design Titanium-Based Materials for Advancing Dental Applications Invited

    Peng Chen, Huiyong Yang, Taishi Yokoi

    The 23rd International Symposium on Eco-Materials Processing and Design　2025/01/13

  5. 酸化銅添加による抗菌性と高強度化を同時に実現したチタン合金の開発 Invited

    陳 鵬, 新村 彩, 董 明琪, 周 偉偉, 野村直之, 金高弘恭

    日本バイオマテリアル学会シンポジウム2024　2024/10/28

  6. Improve the osteoconductivity and antibacterial properties of metallic dental implants through smart surface designing Invited

    Peng Chen, Hiroyasu Kanetaka

    TACT2023 International Thin Film Conference　2023/11/12

  7. Regulation of stem cell behaviors by titanium with multiscaled topography surface design using femtosecond laser International-presentation Invited

    Chen P, Hanawa T

    International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development Satellite (iLIM-s)　2019/11/02

  8. Nanotechnology for intelligent surface designing of metallic implants International-presentation Invited

    Chen P

    International Young Scholars Forum　2019/05/20

  9. Nanotechnology for intelligent surface designing of metallic dental devises International-presentation Invited

    Chen P

    The 2nd International Symposium on Precision Medicine and Biomedical Technologies　2018/12/07

  10. Characterization and cytocompatibility of calcium phosphate ester salts prepared from monovalent and divalent ethyl phosphate monoesters

    Derong Chen, Taishi Yokoi, Hitoshi Amano, Masaya Shimabukuro, Kazuhiro Aoki, Peng Chen, Yuko Matsukawa, Chikara Ohtsuki, Masakazu Kawashita

    The 12th International Symposium on Inorganic Phosphate Materials (ISIPM-12)　2026/08/26

  11. Synthesis of Copper-Containing Bioactive Glass Layers on NaOH-Treated Titanium for Enhanced Antibacterial Activity

    K. Ueda, A.Otsu, K. Ogasawara, H. Kanetaka, P. Chen, T. Narushima

    The 12th Pacific Rim International Conference on Advanced Materials and Processing (PRICM12)　2026/08/09

  12. Rapid and Broad-Spectrum Antimicrobial Behavior of Laser-Cladded Copper Surfaces for Infection-Resistant Biomaterials

    Linjia Li, Peng Chen, Tamaki Yoshida, Keisuke Takenaka, Takayuki Mokudai, Yuji Sato, Masahiro Tsukamoto, Hiroyasu Kanetaka

    The 2nd International Online Conference on Functional Biomaterials (IOCFB2026)　2026/07/10

  13. Microstructurally Refined Ti-6Al-7Nb via High-Pressure Sliding Modulates Osteoblast Adhesion and Proliferation

    Jiale Ma, Peng Chen, Mark Ashida, Hiroyasu Kanetaka

    The 2nd International Online Conference on Functional Biomaterials (IOCFB2026)　2026/07/10

  14. Additive Manufacturing of Bio-functionalized Ti-CuO Alloys: Mechanical and Biological Insights

    Jiatai Chen, Peng Chen, Aya Niimura, Mingqi Dong, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    The 2nd International Online Conference on Functional Biomaterials (IOCFB2026)　2026/07/10

  15. Acute antimicrobial efficacy of gram-negative bacteria by pure copper coating using multi-beam laser metal deposition with blue diode lasers

    Linjia Li, Peng Chen, Tamaki Yoshida, Keisuke Takenaka, Takayuki Mokudai, Yuji Sato, Masahiro Tsukamoto, Hiroyasu Kanetaka

    7th International Conference on Applied Surface Science　2026/06/02

  16. Effects of CuO Addition on Antibacterial, Mechanical, and Cellular Responses of L-PBF Ti-CuO Alloys

    Jiatai Chen, Peng Chen, Aya Nimura, Mingqi Dong, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    7th International Conference on Applied Surface Science　2026/06/02

  17. Effects of CuO Addition on Antibacterial, Mechanical, and Cellular Responses of L-PBF Ti-CuO Alloys

    Jiatai Chen, Peng Chen, Aya Nimura, Mingqi Dong, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    日本歯科理工学会 第84回学術講演会　2026/04/18

  18. Fast-acting antimicrobial behavior of pure copper coatings fabricated by multi-beam blue-diode laser cladding

    Li Linjia, Chen Peng, Yoshida Tamaki, Takenaka Keisuke, Mokudai Takayuki, Sato Yuji, Tsukamoto Masahiro, Kanetaka Hiroyasu

    2026/04/19

  19. ⻭科⽤インプラントへの機能性付与のための⻘⾊半導体レーザマルチビーム⾦属堆積法による純銅コーティング技術の開発

    吉田 環, 福井大和, 竹中啓介, 佐藤雄二, 陳 鵬, 目代貴之, 金髙弘恭, 吉田 実, 塚本雅裕

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和７年度 公開討論会　2026/03/14

  20. Rapid antimicrobial activity of pure copper coatings fabricated by multi-beam blue diode laser cladding

    陳 鵬, 吉田 環, Linjia Li, 福井大和, 竹中啓介, 佐藤雄二, 塚本雅裕, 金髙弘恭

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和７年度 公開討論会　2026/03/14

  21. 塩⽔湖ミネラルにおける抗酸化活性評価と細胞への影響

    目代貴之, 川田巳致, 庭野道夫, 但木大介, 平野愛弓, 陳 鵬, 金髙弘恭

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和７年度 公開討論会　2026/03/14

  22. L-PBF法で作製したTi-CuO合金におけるCuO添加が抗菌性・機械特性および細胞応答に及ぼす影響

    陳 鵬, 新村 彩, Jiatai Chen, 董 明琪, 周 偉偉, 野村直之, 金高弘恭

    日本金属学会2026年春期(第178回)講演大会　2026/03/13

  23. 積層造形Ti–CuO合金における抗菌特性および細胞応答の評価

    陳 鵬, 横井太史, Huiyong Yang

    2025年度生体医歯工学共同研究拠点成果報告会　2026/03/03

  24. 積層造形Ti-CuO合金におけるCuO添加量依存の抗菌性と機械的特性

    Jiatai Chen, Peng Chen, Aya Nimura, Li Chang, Mingqi Dong, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    2025年度日本バイオマテリアル学会東北ブロック交流会　2026/02/18

  25. 歯科インプラント高機能化のための青色半導体レーザーマルチビーム金属堆積法によるチタン上への純銅コーティング

    吉田 環, 福井大和, 竹中啓介, 佐藤雄二, 陳 鵬, 目代貴之, 金髙弘恭, 吉田 実, 塚本雅裕

    レーザー学会第46回年次大会　2026/01/13

  26. Development of Artificial Bones with Unique Mechanical Properties using Organically Modified Octacalcium Phosphate as a Starting Invited

    Taishi Yokoi, Peng Chen, Yeongjun Seo, Tomoyo Goto, Tohru Sekino, Masakazu Kawashita

    The 24th International Symposium on Eco-Materials Processing and Design　2026/01/12

  27. リン酸八カルシウムの特異な結晶化学的性質を利用した生体材料創製の挑戦

    横井太史, 陳 鵬, Yeongjun Seo, 関野 徹, 後藤知代, 川下将一

    第44回整形外科バイオマテリアル研究会　2025/12/13

  28. Duration-Dependent Nitrogen Doping Effects on Titanium Surfaces: Optimizing Antibacterial Performance and Cell Compatibility

    Mohammed N Al-Duais, Li Chang, Peng Chen, Taishi Yokoi, Takayuki Mokudai, Masakazu Kawashita, Hiroyasu Kanetaka

    第86回東北大学歯学会　2025/12/12

  29. チタン表面にコーティングしたとげ状YSZ表面での抗菌性と細胞増殖

    橋本雅美, 山口哲央, 橋本壮真, 北岡 諭, 陳 鵬, 金高弘恭

    日本バイオマテリアル学会大会　2025/11/09

  30. Multi-Beam Laser Metal Deposition of Pure Copper on a Titanium Substrate with Blue Diode Lasers for Surface Functionalization of Dental Implants

    Tamaki Yoshida, Keisuke Takenaka, Yuji Sato, Peng Chen, Takayuki Mokudai, Hiroyasu Kanetaka, Masahiro Tsukamoto

    The 44th annual International Congress on Applications of Lasers & Electro-Optics (ICALEO)　2025/10/13

  31. レーザー粉末床溶融法によるCuO 添加チタン合金の抗菌性および機械的特性評価

    陳 鵬, 新村 彩, Li Chang, 董 明琪, 周 偉偉, 野村直之, 金高弘恭

    第5回日本チタン学会講演大会（2025年度）　2025/10/09

  32. Optimizing nitrogen doping duration on titanium surfaces for dual antibacterial and cytocompatible functions

    Mohammed N. Al-Duais, Li Chang, Peng Chen, Taishi Yokoi, Takayuki Mokudai, Masakazu Kawashita, Hiroyasu Kanetaka

    第5回日本チタン学会講演大会（2025年度）　2025/10/10

  33. Optimizing Nitrogen Doping Duration for Antibacterial and Biocompatible Titanium Surfaces

    Peng Chen, Mohammed N Al-Duais, Li Chang, Taishi Yokoi, Takayuki Mokudai, Masakazu Kawashita, Hiroyasu Kanetaka

    The 5th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJI2MA)　2025/10/01

  34. Development of Pure Copper Coating on a Titanium Substrate for Antimicrobial Functionality in Dental Implants Using Multi-Beam Laser Metal Deposition with Blue Diode Lasers

    Tamaki Yoshida, Yamato Fukui, Keisuke Takenaka, Peng Chen, Takayuki Mokuda, Yuji Sato, Minoru Yoshida, Hiroyasu Kanetaka, Masahiro Tsukamoto

    The 5th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJI2MA)　2025/10/01

  35. Formation of Periodic Nanostructures on Biomaterials with Femtosecond Laser Irradiation Invited

    Keisuke Takenaka, Peng Chen, Yuji Sato, Takayuki Mokudai, Hiroyasu Kanetaka, Masahiro Tsukamoto

    The 5th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJI2MA)　2025/10/01

  36. Interface Summer Seminar 2024 The 19th International Workshop on Biomaterials in Interface Science

    Interface Summer Semina, The, h International Workshop on Biomaterials in, Interface Science

    Interface Summer Seminar 2024 The 19th International Workshop on Biomaterials in Interface Science　2025/08/01

  37. The effect of spot size on layer formation efficiency in pure copper coating using multi-beam laser metal deposition with blue diode lasers

    Tamaki Yoshida, Yuji Sato, Keisuke Takenaka, Peng Chen, Takayuki Mokudai, Yorihiro Yamashita, Masahiro Tsukamoto

    Lasers in Manufacturing (LiM) Conference 2025　2025/06/23

  38. Antibacterial and strengthened titanium alloys via CuO addition using laser powder bed fusion

    Peng Chen, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    第83回日本歯科理工学会学術講演会　2025/04/20

  39. 損傷許容性に優れるジルコニア系複合材料の開発

    横井太史, 陳 鵬, 徐 寧浚, 後藤知代, 関野 徹, 金髙弘恭, 川下将一

    第83回日本歯科理工学会学術講演会　2025/04/19

  40. 医療用途に向けたレーザークラッディング表面加工技術による抗菌性表面の開発

    陳 鵬, 吉田 環, 竹中啓輔, 目代貴之, 佐藤雄二, 塚本雅裕, 金髙弘恭

    ヘルステックコロキウム ＆ 第11回 若⼿研者のためのネットワーキング　2025/03/12

  41. 抗菌性と固溶強化を同時に実現するCuO添加チタン合金の特性評価

    陳 鵬, 新村 彩, 董 明琪, 周 偉偉, 野村直之, 金高弘恭

    日本金属学会 2025年春期講演（第176回）大会　2025/03/08

  42. 金属3D積層造形技術によりTi-Cu合金に抗菌性と強度向上を同時に付

    陳 鵬, 新村 彩, 周 偉偉, 野村直之, 金高弘恭, 横井太史, Huiyong Yang

    2024年生体医歯工学共同研究拠点報告会　2025/03/03

  43. 口腔内洗浄液への適用に向けたプラズマバブル水の殺菌効果と細胞毒性の評価

    大澤泰樹, 劉 子鈺, 栗田理史, 八井田朱音, 大石敦之, 沖野晃俊, 田中佑樹, 土田和徳, 松村有里子, 岩澤篤郎, 陳 鵬, 金髙弘恭

    2024年生体医歯工学共同研究拠点報告会　2025/03/03

  44. Acute antimicrobial efficacy of gram-negative bacteria by pure copper coating using multi-beam laser metal deposition with blue diode lasers

    Peng Chen, Tamaki Yoshida, Keisuke Takenaka, Takayuki Mokudai, Yuji Sato, Masahiro Tsukamoto, Hiroyasu Kanetaka

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和6 年度 公開討論会　2025/03/02

  45. Enhancing titanium osteoconductivity by alkali-hot water treatment

    Hiroyasu Kanetaka, Li Chang, Peng Chen, Takayuki Mokudai, Masakazu Kawashita, Itaru Mizoguchi

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和6 年度 公開討論会　2025/03/02

  46. 表⾯組成・構造制御による抗菌・ウイルス不活化機能の向上

    吉田 環, 竹中啓輔, 佐藤雄二, 陳 鵬, 金髙弘恭, 目代貴之, 松下伸広, 塚本雅裕

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和6 年度 公開討論会　2025/03/02

  47. 超音波技術を利用した微細気泡の生成と評価

    目代貴之, 川田巳致, 庭野道夫, 但木大介, 平野愛弓, 陳 鵬, 金髙弘恭

    国際・産学連携インヴァースイノベーション材料創出プロジェクト（DEJI2MA）令和6 年度 公開討論会　2025/03/02

  48. Pure copper coating by multi beam directed energy deposition with blue lasers for antimicrobial effect

    Tamaki Yoshida, Keisuke Takenaka, Yuji Sato, Peng Chen, Takayuki Mokudai, Hiroyasu Kanetaka, Masahiro Tsukamoto

    The 43rd annual International Congress on Applications of Lasers & Electro-Optics (ICALEO)

  49. 生体模擬環境におけるオーステナイト系ステンレス鋼の高耐食性化

    真中智世, 堤 祐介, 陳 鵬, 蘆田茉希, 片山英樹, 石本卓也, 塙 隆夫

    日本バイオマテリアル学会シンポジウム2024　2024/10/28

  50. Enhancing osteoconductivity and antibacterial properties of titanium via alkali-hot water treatment and nitrogen doping

    Li Chang, Peng Chen, Takayuki Mokudai, Masakazu Kawashita, Itaru Mizoguchi, Hiroyasu Kanetaka

    Scientific Annual Meeting of ADEAP & CA+inD International Symposium 2024　2024/10/19

  51. Nanobubbles produced by ultrasound irradiation and evaluation of functionality

    Takayuki Mokudai, Michi Kawada, Daisuke Tadaki, Ayumi Hirano-Iwata, Peng Chen, Hiroyasu Kanetaka, Hiroshi Fujimori, Emiko Takemoto, Michio Niwano

    The 4th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJl2MA2024)　2024/10/03

  52. Acute antimicrobial efficacy of gram-negative bacteria by pure copper coating using multi-beam laser metal deposition with blue diode lasers

    Peng Chen, Tamaki Yoshida, Keisuke Takenaka, Takayuki Mokudai, Yuji Sato, Masahiro Tsukamoto, Hiroyasu Kanetaka

    The 4th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJl2MA2024)　2024/10/03

  53. Generation of antimicrobial property on material surface by copper coating using multi-beam laser metal deposition system with blue diode lasers

    Tamaki Yoshida, Yuji Sato, Keisuke Takenaka, Satoshi Yoshida, Peng Chen, Hiroyasu Kanetaka, Takayuki Mokudai, Nobuhiro Matsushita, Masahiro Tsukamoto

    The 4th International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJl2MA2024)　2024/10/03

  54. コラーゲン/リン酸カルシウム表面電着によるチタンの軟組織接着性向上

    陳 鵬, 漆間元貴, 真中智世, 堤 晴美, 堤 祐介, 金高弘恭, 塙 隆夫

    第19回ナノ・バイオメディカル学会大会　2024/09/06

  55. Development of antibacterial and mechanically enhanced titanium alloys by CuO addition using laser powder bed fusion

    Peng Chen, Aya Niimura, Minqi Dong, Weiwei Zhou, Naoyuki Nomura, Hiroyasu Kanetaka

    Interface Summer Seminar 2024 The 19th International Workshop on Biomaterials in Interface Science　2024/08/06

  56. Creation of bioactive titanium with both biocompatible and antibacterial properties

    Li Chang, Peng Chen, Takayuki Mokudai, Masakazu Kawashita, Itaru Mizoguchi, Hiroyasu Kanetaka

    Interface Summer Seminar 2024 The 19th International Workshop on Biomaterials in Interface Science　2024/08/06

  57. き裂進展阻害機能を有するジルコニア系複合材料の作製

    横井太史, 後藤知代, 関野徹, 陳 鵬, 金髙弘恭, 川下将一

    日本バイオマテリアル学会関西ブロック 第19回若手研究発表会　2024/07/27

  58. 新生骨の再生促進するチタンインプラント表面ナノ微細構造の設計

    陳 鵬, 竹中啓輔, 佐藤雄二, 横井太史, 川下将一, 塙 隆夫, 塚本雅裕, 金高弘恭

    第18回ナノ・バイオメディカル学会大会　2023/11/30

  59. Improve the soft tissue adhesion of titanium by surface electrodeposition of collagen and calcium phosphate

    Uruma M, Chen P, Manaka T, Kanetaka H, Hanawa T

    TACT2023 International Thin Film Conference

  60. Evaluation of osteogenic properties of bioactive porous titanium for orthodontic applications

    Chang L, Chen P, Mokudai T, Kawashita M, Kanetaka H, Mizoguchi I

    TACT2023 International Thin Film Conference

  61. Pure copper layer formation for anti-virus by multi-beam laser metal deposition with blue diode lasers

    Tamaki Yoshida, Keisuke Takenaka, Yuji Sato, Peng Chen, Hiroyasu Kanetaka, Nobuhiro Matsushita, Masahiro Tsukamoto

    3rd International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture -DEJl²MA 2023-　2023/10/20

  62. Development of Bioinspired Damage-tolerant Calcium Phosphate/Pyrolytic Carbon Composite Materials

    Yokoi T, Kuroyama K, Goto T, Sekino T, Chen P, Kanetaka H, Shimabukuro M, Kawashita M, Yoda T

    3rd International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture -DEJl²MA 2023-　2023/10/20

  63. Visible-light–induced photocatalytic activity of nitrogen-doped TiO2 and evaluation of functionality

    Mokudai T, Chang L, Chen P, Kawashita M, Mizoguchi I, Kanetaka H

    3rd International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture -DEJl²MA 2023-　2023/10/20

  64. Osteoconductive and osteoinductive surface design of titanium using femtosecond laser irradiation

    Chen P, Takenaka K, Mokudai T, Sato Y, Tsukamoto M, Hanawa T, Kanetaka H

    3rd International Symposium on Design & Engineering by Joint Inverse Innovation for Materials Architecture -DEJl²MA 2023-　2023/10/20

  65. The effects of alkali and hot water treatments on the osteogenic properties of porous titanium for orthodontic applications

    Chang L, Chen P, Mokudai T, Kawashita M, Kanetaka H, Mizoguchi I

    The 18th International Workshop on Biomaterials in Interface Science　2023/08/04

  66. Development of bioinspired damage-tolerant calcium phosphate-based bulk ceramic materials

    Yokoi T, Kuroyama K, Goto T, Sekino T, Chen P, Kanetaka H, Shimabukuro M, Kawashita M, Yoda T

    The 18th International Workshop on Biomaterials in Interface Science　2023/08/04

  67. Nano-topography design for promoting the osteoconductivity of titanium using femtosecond laser irradiation

    Chen P, Takenaka K, Ashida M, Yokota K, Mokudai T, Sato Y, Tsutsumi Y, Tsukamoto M, Kanetaka H, Hanawa T

    The 18th International Workshop on Biomaterials in Interface Science　2023/08/04

  68. フェムト秒レーザ照射でチタン表面に形成した微細構造パターンによる骨芽前駆細胞の増殖と石灰化のバランスの調節

    陳 鵬, 篠原直樹, 篠永東吾, 佐藤雄二, 塚本雅裕, 蘆田茉希, 塙 隆夫

    日本金属学会2020年秋期(第167回)講演大会　2020/09/18

  69. Creation of titanium surface fabricated by femtosecond laser on which proliferation and calcification of MC3T3-E1 cell are accelerated

    Chen P, Shinohara N, Shinonaga T, Sato Y, Tsukamoto M, Ashida M, Hanawa T

    The 2020 Spring Metting of the Japan Institute of Metals and Materials　2020/03/19

  70. Multi-scaled hierarchical patterned titanium surface regulated proliferation and calcification behaviours of preosteoblast

    Chen P, Miyake M, Shinohara N, Tsukamoto M, Ashida M, Hanawa T

    The 41st Annual Meeting of the Japanese Society for Biomaterials　2019/11/24

  71. Calcification promotion of preosteoblast by titanium with chessboard-patterned nano surface topography produced with femtosecond laser irradiation International-presentation

    Chen P, Shinohara N, Shinonaga T, Tsukamoto M, Ashida M, Tsutsumi Y, Hanawa T

    International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development Satellite (iLIM-s)　2019/11/02

  72. Regulation of preosteoblast behaviors by multi-scaled hierarchical patterned titanium surface fabricated with femtosecond laser irradiation International-presentation

    Chen P, Shinohara N, Shinonaga T, Tsukamoto M, Ashida M, Tsutsumi Y, Hanawa T

    The 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-4)　2019/10/03

  73. Maintenance and self-renewal of mesenchymal stem cells cultured on titanium with periodic micro/nanometer scaled topographies produced by femtosecond laser irradiation

    Chen P, Ashida M, Hanawa T

    2019 Annual Autumn (165th) Meeting of JIM　2019/09/11

  74. Promotion of osteoconductivity of titanium with multi-scaled hierarchical patterned topography fabricated by femtosecond laser irradiation International-presentation

    Chen P, Takenaka K, Tsukamoto M, Ashida M, Tsutsumi Y, Hanawa T

    The 10th Pacific Rim International Conference on Advanced Materials and Processing (PRICM10)　2019/08/18

  75. Promoted osteoconductivity of titanium with chessboard-patterned surface nano topography fabricated by femtosecond laser irradiation International-presentation

    Chen P, Takenaka K, Tsukamoto M, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    Society for Biomaterials 2019 Annual Meeting and Exposition (SFB2019)　2019/04/03

  76. Osteoconductivity promotion of titanium with checkerboardpatterned periodic micron/nano-ripples topography fabricated by femtosecond laser

    Chen P, Takenaka K, Shinonaga T, Tsutsumi Y, Ashida M, Doi H, Tsukamoto M, Hanawa T

    2019 Annual Spring (164th) Meeting of JIM　2019/03/20

  77. Promoted osteoconductivity of titanium with checkerboard-patterned surface nano topography fabricated by femtosecond laser irradiation

    he, Open Discussion, Symposium on Creation of Life, Innovation Materials for Interdisciplinary, International Researcher Development

    2019/03/05

  78. Multiscale, hierarchically patterned titanium topography for regulating adhesion and calcification of preosteoblast

    Chen P, Takenaka K, Tsukamoto M, Ashida M, Doi H, Tsutsumi Y, Hanawa T

    The 28th Intelligent Nanomaterials Symposium　2019/01/11

  79. Calcification of preosteoblast cultured on titanium surfaces with different patterned nano-topographies produced with femtosecond laser irradiation International-presentation

    Chen P, Takenaka K, Tsukamoto M, Ashida M, Doi H, Tsutsumi Y, Hanawa T

    The 3rd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-3)　2018/09/25

  80. Multi-scaled hierarchical topography of titanium regulated adhesion and multi-differentiation of mesenchymal stem cells International-presentation

    Chen P, Aso T, Sasaki R, Ashida M, Doi H, Tsutsumi Y, Hanawa T

    Biointerfaces International 2018　2018/08/14

  81. Adhesion and differentiation of mesenchymal stem cells response to Ti surface with multi-scaled topographies International-presentation

    Chen P, Aso T, Sasaki R, Ashida M, Doi H, Tsutsumi Y, Hanawa T

    Biomaterials International 2018　2018/07/23

  82. チタン表面にフェムト秒レーザーにより形成した周期的微細構造が細胞の石灰化に与える影響

    陳 鵬, 三宅正誉志, 竹中啓輔, 篠永東吾, 蘆田茉希, 土居 壽, 堤 祐介, 塚本雅裕, 塙 隆夫

    「学際・国際的高度人材育成ライフイノベーションマテリアル創製共同研究プロジェクト」（6大学連携プロジェクト）第2回公開討論会　2018/03/30

  83. Micro-/nanometer-ordered three-dimensional periodic structures formed on titanium surface by femtosecond laser irradiation regulated morphology and differentiation of mesenchymal stem cells

    Chen P, Aso T, Sasaki R, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    The 17th Congress of the Japanese Society for Regenerative Medicine　2018/03/21

  84. Adhesion and differentiation of mesenchymal stem cells on titanium with grid surface topographies formed by femtosecond laser

    Chen P, Aso T, Sasaki R, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    2018 Annual Spring (162th) Meeting of JIM　2018/03/19

  85. Effect of fine periodic structure formed by femtosecond laser irradiation on adhesion and differentiation of mesenchymal stem cells on titanium

    Chen P, Tsutsumi Y, Doi H, Hanawa T

    The 27th Intelligent Materials/Systems Symposium　2018/01/10

  86. Nanoarchitectures of Ti surface promote adhesion and differentiation of mesenchymal stem cells

    Chen P, Aso T, Sasaki R, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    The 39th Annual Meeting of the Japanese Society for Biomaterials　2017/11/20

  87. Calcification of preosteoblasts cultured on titanium with periodic micron/nano-groove topography produced with femtosecond laser irradiation International-presentation

    Chen P, Tsukamoto M, Shinonaga T, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 2nd International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-2)　2017/09/29

  88. Nanotechnology in implant dentistry and bone regeneration International-presentation Invited

    Chen P

    The 1st International Symposium on Precision Medicine and Biomedical Technologies　2017/06/04

  89. Micron/nano hierarchical topography of titanium surface influences adhesion and multi-differentiation behaviours of mesenchymal stem cells International-presentation

    Chen P, Hanawa T, Aso T, Sasaki R, Tsutsumi Y, Ashida M, Doi H

    Society for Biomaterials 2017 Annual Meeting and Exposition (SFB2017)　2017/04/05

  90. Grid patterns on titanium surface promote adhesion and differentiation of mesenchymal stem cells International-presentation

    Chen P, Aso T, Sasaki R, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    Society for Biomaterials 2017 Annual Meeting and Exposition (SFB2017)　2017/04/05

  91. Biocompatibility evaluation of nanostructured titanium surface using femtosecond laser

    Chen P, Miyake M, Shinonaga T, Tsukamoto M, Tsutsumi Y, Hanawa T

    The 1st Open Discussion Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development　2017/03/30

  92. Calcification of preosteoblasts cultured on titanium with periodic topography produced with femtosecond laser irradiation

    Chen P, Miyake M, Tsukamoto M, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    2017 Annual Spring (160th) Meeting of JIM　2017/03/15

  93. Morphological control and differentiation induction of mesenchymal stem cells with titanium surface irradiated with femtosecond laser

    Chen P, Aso T, Sasaki R, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 26th Intelligent Materials/Systems Symposium　2017/01/11

  94. Role of periodic nano-topography of titanium on calcification of preosteoblast

    Chen P, Kawa T, Miyake M, Tsukamoto M, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    Symposium of Japanese Society for Biomaterials 2016　2016/11/21

  95. Calcification of preosteoblast on nano topography fabricated by femtosecond laser International-presentation

    Chen P, Kawa T, Miyake M, Ooga T, Tsukamoto M, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-1)　2016/10/17

  96. Role of hierarchical topography of titanium surface on mesenchymal stem cells adhesion and differentiation behaviours in vitro International-presentation

    Chen P, Aso T, Sasaki R, Tsutsumi T, Ashida M, Doi H, Hanawa T

    The 10th World Biomaterials Congress (WBC2016)　2016/05/17

  97. Different mechanisms of bone formation of preosteoblast on metals in vitro International-presentation

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 10th World Biomaterials Congress (WBC2016)　2016/05/17

  98. Role of topography of titanium surface on multiple differentiations of mesenchymal stem cells

    Chen P, Aso T, Sasaki R, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    2016 Annual Spring (158th) Meeting of JIM　2016/03/23

  99. Calcification of MC3T3-E1 cells on titanium and zirconium

    Chen P, Umezawa T, Tsutsumi Y, Ashida M, Doi H, Suzuki S, Moriyama K, Hanawa T

    The 25th Intelligent Materials/Systems Symposium　2016/01/08

  100. Role of topography of titanium surface on mesenchymal stem cells behaviors

    Chen P, Aso T, Sasaki R, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 37th Annual Meeting of the Japanese Society for Biomaterials　2015/11/09

  101. Morphological modulation of mesenchymal stem cells on titanium with grooves formed by femtosecond laser

    Chen P, Aso T, Sasaki R, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    2015 Annual Fall (157th) Meeting of JIM　2015/09/16

  102. Effect of sputter-deposited metals on osteogenic potential of preosteoblast cells International-presentation

    Chen P, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    The 6th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-6)　2015/06/09

  103. Osteogenic activity of MC3T3-E1 cells on sputter-deposited metals International-presentation

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 5th Asian Biomaterials Congress (ABMC5)　2015/05/06

  104. Extension, locomotion, and proliferation of osteoblast-like cells on metals. Society for Biomaterials 2015 Annual Meeting and Exposition (SFB2015) International-presentation

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    Society for Biomaterials 2015 Annual Meeting and Exposition (SFB2015)　2015/04/15

  105. Cellular and gene expression responses in osteoblast-like cells to metals International-presentation

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    Society for Biomaterials 2015 Annual Meeting and Exposition (SFB2015)　2015/04/15

  106. Biocompatibility of Ti-6Al-7Nb processed by high-pressure torsion in vitro

    Chen P, Ashida M, Tsutsumi Y, Doi H, Hanawa T, Horita Z

    2015 Annual Spring (156th) Meeting of JIM　2015/03/18

  107. Effect of spatter deposited metal surfaces on osteoblast-like cell behaviors in vitro

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 24th Intelligent Materials/Systems Symposium　2015/01/19

  108. Evaluation of biocompatibility of metallic materials in osteoblast-like cell

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    The 36th Annual Meeting of the Japanese Society for Biomaterials　2014/11/18

  109. In vitro differentiation and calcification of osteoblast -like cell cultured on metals International-presentation

    Chen P, Ashida M, Tsutsumi Y, Doi H, Hanawa T

    The 5th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-5)　2014/10/19

  110. Activation of gene expression of osteoblast-like cell cultured on metals

    Chen P, Tsutsumi Y, Ashida M, Doi H, Hanawa T

    2014 Annual Fall (155th) Meeting of JIM　2014/09/24

  111. Effect of metal surfaces on osteoblast-like cell behaviors in vitro

    Chen P, Ashida M, Doi H, Tsutsumi, Hanawa T

    2014 Annual Spring (154th) Meeting of JIM　2014/03/23

  112. Toll like receptor, an important role at the nano-bio interface

    Chen P, Taniguchi A, Ashida M, Doi H, Tsutsumi Y, Hanawa T

    The 23rd Intelligent Materials/Systems Symposium　2014/01/14

  113. Role of Toll-Like Receptors in Cellular Uptake and Response to Nanoparticles Exposure International-presentation

    Chen P, Taniguchi A

    The 4th Asian Biomaterials Congress　2013/06/26

  114. Detection of DNA damage response by different forms of titanium dioxide nanoparticles using sensor cells

    Chen P, Taniguchi A

    The Symposium of Japanese Society for Biomaterials 2012　2012/11/26

  115. Live-cell based sensor cells, a novel method to investigate the roles of TLR3 and TLR4 in the interaction between TiO2 nanoparticles and cells International-presentation

    Chen P, Taniguchi A

    IUMRS International Conference on Electronic Materials 2012　2012/09/23

  116. Detection of Cytotoxic Responce for Titanium Dioxide Nanoparticles Using Heat Shock Protein 70B' Promoter International-presentation

    Chen P, Taniguchi A

    The 9th World Biomaterials Congress (WBC9)　2012/06/01

  117. Development of sensor cells for detection of titanium dioxide nanoparticle agglomerates

    Chen P, Taniguchi A

    Tsukuba Biomedical Forum 2012　2012/01/18

  118. Development of sensor cells for detection of interaction between the cells and nanoparticles

    Chen P, Taniguchi A

    The 21st Symposium on Intelligent Materials/Systems　2012/01/10

  119. Development of sensing cells for nanomaterials safety evaluation using heat shock proteins promoter

    Chen P, Taniguchi A

    The 33rd Annual Meeting of the Japanese Society for Biomaterials　2011/10/21

  120. Development of sensor cells for cytotoxic detection of nanomaterials International-presentation

    Chen P

    UCAM/NIMS/UCLA Summer School　2011/09

  121. Monitoring the Titanium Dioxide induced Inflammation by Modified Sensing Cells using NF-κB activation pathway International-presentation

    Chen P, Migita S, Taniguchi A

    The MANA International Symposium 2011　2011/03/02

  122. Development of Inflammation Sensing Cells Using NF-κB Activation Pathway International-presentation

    Chen P, Migita S, Taniguchi A

    The 2nd NIMS(MANA)-Waseda International Symposium　2010/12/01

  123. Activated carbon electrodes based on natural polymer for supercapacitors International-presentation

    Chen P, Jin H-J

    The 6th International Conference on Advanced Materials and Devices　2009/12

  124. Nylon 610 hollow nanofibers prepared by coaxial electrospinning

    Chen P, Jin H-J

    2009 Annual Fall Meeting of Polymer Society of Korea　2009/10

  125. Silk Fibroin/Bacterial Cellulose Nanocrystal Composite Nanofibers Prepared by Electrospinning

    Chen P, Jin H-J

    2009 Annual Fall Meeting of Polymer Society of Korea　2009/10

  126. Multiwalled Carbon Nanotubes-embedded Electrospun Bacterial Cellulose Nanofibers International-presentation

    Chen P, Jin H-J

    KJF- International Conference on Organic Materials for Electronics and Photonics　2009/08

  127. Carbon Nanotubes-Embedded Electrospun Cellulose Nanofibers International-presentation

    Peng CHEN

    2009 Sichuan-Inha Symposium on Advanced Polymeric Materials　2009/04

  128. Regenerated Bacterial Cellulose Fibers Prepared by Electrospinning

    Chen P, Jin H-J

    2009 Annual Spring Meeting of Polymer Society of Korea　2009/03

  129. Regenerated Bacterial Cellulose Fibers Prepared by Electrospinning

    Chen P, Jin H-J

    2008 Annual Fall Meeting of Polymer Society of Korea　2008/10

  130. In-Situ Polymerized Carbon Nanotube Composite Fibers

    Chen P, Jin H-J

    Proceedings of the Korea Textile Conference,　2008/10

  131. Regenerated Bacterial Cellulose/Multiwalled Carbon Nanotueb Fibers Prepared by Wet-spinning International-presentation

    Chen P, Jin H-J

    The 6th International Nanotech symposium & exhibition in Korea (Nano Korea 2008)　2008/08

  132. Characterization of Silk Fibroin Nanoparticles Fabricated by Microemulsion Method International-presentation

    Chen P, Jin H-J

    The 22nd International Liquid Crystal Conference　2008/06

  133. Nanofibril formation from a spherical micelle of Bombyx mori silk fibroin by pH-adjusting International-presentation

    Chen P, Jin H-J

    2008 Niigata-Inha Joint Symposium on Advanced Polymeric Materials　2008/05

  134. Mechanical Properties of Regenerated Bacterial Cellulose/Multiwalled Carbon Nanotueb Fibers Prepared by Wet-spinning

    Chen P, Jin H-J

    2008 Annual Spring Meeting of Polymer Society of Korea　2008/04

  135. Dispersion of Multiwalled Carbon nanotubes in Aqueous Silk Fibroin Solutions International-presentation

    Chen P, Jin H-J

    2007 International Conference on Nano Science and Nano Technology　2007/11

  136. Functional Nanocomposites Based on Bacterial Cellulose

    Chen P, Jin H-J

    Proceedings of the Korea Textile Conference　2007/11

  137. pH-Dependent Supramolecular Structure of Silk Fibroin in Water

    Chen P, Jin H-J

    2007 Annual Fall Meeting of Polymer Society of Korea　2007/10

  138. Preparation of Multiwalled Carbon Nanotubes incorporated Silk Fibroin Nanofibers by Electrospinning International-presentation

    Chen P, Jin H-J

    The 5th International Nanotech symposium & exhibition in Korea (Nano Korea 2007)　2007/08

  139. Laser-processed copper coatings for antimicrobial properties on metal substrates

    Peng Chen, Tamaki Yoshida, Keisuke Takenaka, Takayuki Mokudai, Yuji Sato, Masahiro Tsukamoto, Hiroyasu Kanetaka

    Scientific Annual Meeting of ADEAP & CA+inD International Symposium 2024　2024/10/19

  140. Regulation of proliferation and calcification of preosteoblast by titanium surface with checkerboard-patterned nano topography fabricated by femtosecond laser

    Chen P, Shinohara N, Shinonaga T, Sato Y, Tsukamoto M, Ashida M, Hanawa T

    2020/03/04

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Industrial Property Rights 4

  1. 培養基材、及び培養基材の作製方法

    朝生 敏裕, 笹木 隆一郎, 塙 隆夫, 陳 鵬

    Property Type: Patent

  2. 培養基材

    笹木 隆一郎, 朝生 敏裕, 塙 隆夫, 陳 鵬

    Property Type: Patent

  3. 高強度と抗菌性を有する生体用インプラント、Ｔｉ合金、造形体及びＴｉ合金の製造方法

    野村直之, 周 偉偉, 陳 鵬, DONG MINGQI, 金髙弘恭

    Property Type: Patent

  4. 培養基材、及び培養基材の作成方法

    塙 隆夫, 陳 鵬, 朝生敏裕, 笹木隆一郎

    Property Type: Patent

Research Projects 14

  1. 抗菌性と生体親和性の両立を目指したイットリア部分安定化ジルコニアの生体機能化

    金高 弘恭, 北岡 諭, 陳 鵬, 目代 貴之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2026/04 - 2029/03

  2. Establishing a New Foundation for Dental Treatment Based on Ultrafine Grain Control through Severe Plastic Deformation of Titanium Alloys and Elucidation of the Mechanism of Cell Adaptability and New Bone Regeneration

    Peng Chen, Maki Ashida, Hiroyasu Kanetaka

    Offer Organization: The Amada Foundation

    2025/04 - 2027/03

  3. Evaluation of cytocompatibity and osteoconductivity of Ti-6Al-7Nb alloy with refining grain size via high-pressure sliding process

    Peng Chen, Maki Ashida

    Offer Organization: The Light Metal Educational Foundation, Inc.

    Category: Research Grant

    2024/10 - 2027/03

  4. Creating smart surface designs for next-generation dental implant materials by laser cladding

    Offer Organization: Joining and Welding Research Institute, Osaka University

    2023/09 - 2027/03

  5. Design & Engineering by Joint Inverse Innovation for Materials Architecture (DEJl²MA)

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology (MEXT)

    2021 - 2027

  6. Exploratory Study on the Initial Toxicity of Microplastics Derived from Orthodontic Clear Aligners on Human Gastrointestinal Cells

    Peng Chen, Hiroyasu Kanetaka, Masako Toda

    Offer Organization: Innovative Food Science Hub (SHOKU-gaku)

    System: Innovative Food Science Hub Collaborative Research Startup Support Program 2025

    Institution: Tohoku University

    2025/03 - 2026/04

  7. Simultaneous antibacterial and inflammation-relieving properties on titanium using 3D additive manufacturing

    Offer Organization: The Japan Institute of Metals and Materials

    Category: 4th Frontier Research Grant

    Institution: Tohoku University

    2023/10 - 2025/10

  8. Development of innovative zirconia artificial bones

    Yokoi Taishi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tokyo Medical and Dental University

    2022/06/30 - 2024/03/31

    More details Close

    Although zirconia has excellent mechanical properties, it cannot be used as an artificial bone because it does not have bone-binding properties. On the other hand, calcium phosphates have inferior mechanical properties to zirconia, but have bone-binding properties and are therefore used clinically as an artificial bone. In this study, we aimed to develop an innovative zirconia-based artificial bone that combines the advantages of both zirconia and calcium phosphates. The material made by mixing powder made from carboxylate-containing octacalcium phosphate with zirconia and sintering the mixture was found to strongly inhibit the propagation of cracks. In addition, it was demonstrated that the material has strength three times that of conventional calcium phosphate, and the design guidelines for next-generation artificial bones were successfully established.

  9. Creation of next-generation implant surface design to promote bone regeneration with nano-topography patterning

    CHEN PENG

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tokyo Medical and Dental University

    2020/04/01 - 2023/03/31

    More details Close

    The aim of this project, with originality in conceiving a smart surface design that promotes new bone formation around the implant body, the titanium (Ti) surface with different patterned periodic micro/nano-topographies were created by femtosecond laser irradiation. As a result, it was showed that the adhesion protein was well arranged by micron/nano periodic structure (Hybrid) using laser irradiation. In addition, we designed checkerboard surface pattern with micron/nano periodic structure showed the alternative hard tissue compatibility, both osteogenic differentiation and proliferation. Therefore, the checkerboard surface pattern with micron/nano periodic topography we created successfully promoted the regeneration of new bone in vitro and our findings provide a basis for the design of novel biomaterial surfaces that can regulate specific cellular functions with potential clinical applications.

  10. 制菌性を有する二元系チタン合金の不動態膜の特性解析

    高橋 正敏, 高田 雄京, 坂詰 花子, 塙 隆夫, 蘆田 茉希, 陳 鵬

    Offer Organization: 生体医歯工学共同研究拠点

    2022/05 - 2023/03

  11. 試作歯科用チタン合金の表面特性解析

    高橋正敏, 高田雄京, 坂詰花子, 塙隆夫, 蘆田 茉希, 陳 鵬

    Offer Organization: 生体医歯工学共同研究拠点

    2020/05 - 2022/03

  12. Creation of intelligent interface to promote regeneration of new bone of titanium implant materials Competitive

    CHEN Peng

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tokyo Medical and Dental University

    2017/04/01 - 2020/03/31

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    The aim of this project was to promote the regeneration of new bone around metallic implant materials by designing a nano-scaled topography on titanium (Ti) surface with femtosecond laser irradiation. Ti specimens with paralleled or crossed periodic grooves with multi-scales (micron, nano, or micron/nano hierarchical (hybrid) scales) were fabricated by femtosecond laser scanning. Among designed surface topographies, the hybrid surface topography showed an effective control of cellular adhesion behavior. In addition, our results also showed that a significant promotion of osteogenic differentiation and followed calcification deposition were observed by both human mesenchymal stem cells and mouse preosteoblasts cultured on the hybrid topography. Therefore, the micron/nano hierarchical topography we created successfully promoted the regeneration of new bone in vitro and our findings provide a basis for the design of novel biomaterial surfaces that can regulate specific cellular functions.

  13. Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development Competitive

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology (MEXT)

    2016 - 2020

  14. Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials Competitive

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology (MEXT)

    2011 - 2016

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