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Tetsuji Aoyagi

Section

Graduate School of Medicine

Job title

Professor

Degree

researchmap

https://researchmap.jp/ta-tohoku_73

J-GLOBAL ID

201801016927040044

Research History 9

2023/04 - Present

Tohoku University Graduate School of Medicine
2018/02 - 2021/03

Tohoku University　Graduate School of Medicine
2017/03 - 2018/01

Tohoku University　Graduate School of Medicine
2015/03 - 2017/02

University of Michigan　Pulmonary and Critical Care Medicine　Visiting Professor
2014/05 - 2017/02

Tohoku University　Graduate School of Medicine
2010/07 - 2014/04

東北大学病院　検査部　助教
2010/04 - 2010/06

東北大学病院　検査部　医員
2006/04 - 2010/03

Tohoku University　Graduate School of Medicine
2021/04 -

東邦大学医学部　微生物・感染症学講座　准教授

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Research Interests 4

Host Defense
Innate Immunity
Acute Lung Injury
Sepsis

Research Areas 1

Life sciences / Infectious disease /

Papers 92

Immunological mechanism behind reactivated cryptococcosis in persistently infected mice following FTY720 treatment. International-journal

Michiko Yoshida, Ko Sato, Nana Nakahata, Hayato Sato, Reina Ohagi, Emi Kanno, Hiromasa Tanno, Keiko Ishii, Tetsuji Aoyagi, Atsuo Kikuchi, Kazuyoshi Kawakami

Infection and immunity　e0061225　2026/04/30

DOI： 10.1128/iai.00612-25 　

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The Cryptococcus neoformans species complex (CNSC), responsible for cryptococcosis, is controlled by Th1-type immunity, in which IFN-γ-activated macrophages form granulomas that contain infection. Nevertheless, CNSC can evade host immunity and, after the primary infection phase, can shift to a latent infection similar to tuberculosis. Reactivation is thought to occur when immune control fails, but the underlying mechanisms remain poorly understood. FTY720, a functional antagonist of sphingosine-1-phosphate receptors, is primarily used in the treatment of multiple sclerosis. However, there have been reports linking its use to instances of cryptococcosis in patients undergoing treatment. To explore this, we established a novel mouse model using CnT-II mice, which express CD4+ T cell receptors specific for chitin deacetylase 2 (Cda2), a major T cell antigen of CNSC. Following infection with encapsulated CNSC, mice developed persistent pulmonary fungal burdens (10²-10³ CFU) accompanied by granulomatous responses, modeling latent infection. Upon FTY720 administration, mice exhibited increased pulmonary fungal burdens, disrupted granuloma integrity, and reduced IFN-γ and IL-12 production. FTY720 also markedly decreased CD4+ effector memory (Tem) and effector T cells (Teff) in the lungs, with a particularly profound loss of IFN-γ-producing Tem cells. These findings indicate that our model successfully recapitulates latent cryptococcal infection and reactivation, and demonstrate that FTY720 promotes relapse by depleting protective IFN-γ-producing CD4+ Tem cells and impairing Th1-mediated immunity. Given the rising use of FTY720, our study highlights its potential risk in patients with subclinical cryptococcosis and underscores the need for preventive strategies to avert disease progression.
広範な病変を呈した播種性皮膚Mycobacterium chelonae感染症の1例

大藪公平, 馬場啓聡, 粟田潤, 清家一生, 北村知穂, 武井健太郎, 中山麻美, 大島謙吾, 青柳哲史

感染症学雑誌　100　(1)　98-98　2026/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
High Fat Diet-Induced Obesity Alters Cutaneous Immune Cell Function, and These Changes Persist After Weight Loss. International-journal

Wakana Kamada, Hiromasa Tanno, Rena Takayashiki, Yuki Sato, Shinyo Ishi, Miki Shoji, Ko Sato, Tetsuji Aoyagi, Emi Kanno

Journal of immunology research　2026　(1)　e3930910　2026

DOI： 10.1155/jimr/3930910 　

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Obesity is recognized as a chronic low-grade inflammation that contributes to metabolic disorders. Weight loss (WL) is well known to improve metabolic disorders. However, recent studies have shown that the changes in immune cells associated with obesity exhibit immunological memory even after WL. Obesity impairs skin barrier function and exacerbates inflammatory skin diseases, such as psoriasis. While skin immune cells maintain homeostasis and defense, the impact of obesity on these cells in intact skin is understudied, as research mainly focuses on skin with an inflammatory skin disease model in the context of obesity. The effect of WL on skin immunity is even less clear. Therefore, this study aimed to investigate these discrepancies. Mice were assigned to the lean group (regular diet), the obese group (high-fat diet for 18 weeks), and the WL group (high-fat diet for 9 weeks followed by regular diet for 9 weeks). Following 18 weeks of feeding, mouse skin was excised, and immune cell populations within the skin were analyzed using real-time PCR and flow cytometry. In addition, the effects of WL on psoriasis were examined using an imiquimod-induced psoriasis mouse model. We observed increased expression of RORγt, IL-17A, and CCL20 in intact skin in both the obese and WL groups. In the psoriasis model, disease severity was further exacerbated by WL. Moreover, whereas the Vγ4+Vγ5- γδ T cell population was increased in the lean group, the Vγ4-Vγ5- γδ T cell population remained elevated following WL, similar to levels observed in the obese group. These observations indicated that obesity may imprint a memorized immune response in the skin, which is not abrogated by WL. This study is the first to demonstrate this persistent effect on skin immunity. These findings imply that individuals who have experienced obesity may remain at increased risk for inflammatory skin conditions, even after WL.
NKT cell–dependent PspA-specific IgA production caused by mucosal administration of a novel nanoparticle pneumococcal vaccine

Ayako Nakahira, Hiroki Iwaoka, Ko Sato, Shigenari Ishizuka, Ryuhei Shiroma, Tomomitsu Miyasaka, Emi Kanno, Hiromasa Tanno, Yuki Sato, Yukihiro Akeda, Kazunori Oishi, Tetsuji Aoyagi, Keiko Ishii, Kazuyoshi Kawakami

Vaccine　68　127911-127911　2025/12
Publisher: Elsevier BV
DOI： 10.1016/j.vaccine.2025.127911 　

ISSN： 0264-410X
Defect of Dectin-1-mediated signaling promotes burn wound healing through attenuated oxidative stress and inflammatory responses

Yuki Sato, Hiromasa Tanno, Toshiro Imai, Mai Konno, Rena Takayashiki, Wakana Kamada, Eiki Ito, Ikue Sone, Shiho Kawamoto, Shinyo Ishi, Ko Sato, Keiko Ishii, Tetsuji Aoyagi, Yoichiro Iwakura, Emi Kanno

Burns　51　(9)　107703-107703　2025/12
Publisher: Elsevier BV
DOI： 10.1016/j.burns.2025.107703 　

ISSN： 0305-4179
High-risk clonal expansion of IMP-producing Enterobacter cloacae complex in regional Japanese healthcare settings

Kentarou Takei, Hajime Kanamori, Ryuji Sakata, Miho Ogawa, Hiroaki Baba, Yumiko Takei, Asami Nakayama, Tetsuji Aoyagi

Antimicrobial Agents and Chemotherapy　2025/10/17
Publisher: American Society for Microbiology
DOI： 10.1128/aac.00953-25 　

ISSN： 0066-4804

eISSN： 1098-6596

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ABSTRACT Carbapenemase-producing Enterobacter cloacae complex (CPEC) represents an emerging threat in healthcare settings; however, its spread across local and regional hospitals remains elusive. Between 2014 and 2022, 211 non-duplicate E. cloacae complex isolates (ECC) with reduced carbapenem susceptibility based on automated susceptibility testing were collected from 58 hospitals in 14 prefectures across Japan. PCR detected the bla _IMP-1 group in 92.9% of isolates. Among these, 80 representative CPEC isolates underwent whole-genome sequencing. Two dominant high-risk clonal groups, ST78 and ST133 (including single-locus variants), accounted for 62.5% of sequenced isolates. Notably, ST133—rarely reported in Japan—was the second most common type and detected widely, suggesting gradual and inconspicuous dissemination. ST78 exhibited substantial genomic diversity, frequent co-carriage of extended-spectrum beta-lactamase genes, and multiple plasmid replicons, while ST133 formed a more uniform lineage with limited resistance determinants. Most isolates remained highly susceptible to amikacin and cefiderocol. Core-genome multi-locus sequence typing suggested possible intra-facility persistence and inter-facility transmission of closely related strains (≤10 allele differences) in some hospitals over time. Among the 46 facilities with bla _IMP-1 group-positive isolates, 73.9% (34/46) were small hospitals (<200 beds). The proportion among screened ECC isolates was similarly high in small and large hospitals (90.5% vs 94.8%), with no significant difference, suggesting the need to extend molecular surveillance even in resource-limited settings. These findings highlight the utility of molecular confirmation and targeted genomic analysis, particularly in regions or settings where high-risk CPEC clones may circulate undetected, to support timely detection and containment efforts.
カンボジア渡航歴のある日本人男性に発症したセフタジジム耐性Burkholderia pseudomalleiによる類鼻疽の1例

吉田美智子, 馬場啓聡, 大島謙吾, 武井健太郎, 清家一生, 青柳哲史, 齋木佳克, 熊谷紀一郎, 高橋悟朗, 伊藤校輝, 板垣皓大, 工藤淳, 千葉美紀子, 木村裕子, 北村知穂, 遠藤春樹, 石戸谷真帆, 池田しのぶ, 荒井由美子

病原微生物検出情報月報　46　(10)　209-210　2025/10
Publisher: 国立健康危機管理研究機構国立感染症研究所感染症サーベイランス研究部
ISSN： 0915-5813
Enhanced endotoxin release by select generic meropenem formulations in Pseudomonas aeruginosa. International-journal

Masato Kawamura, Tetsuji Aoyagi, Shigeru Fujimura

International journal of antimicrobial agents　66　(6)　107593-107593　2025/08/20

DOI： 10.1016/j.ijantimicag.2025.107593 　
Validation of the United States isolation termination criteria using virus culture results of the omicron variant in Japan. International-journal

Issei Seike, Hiroaki Baba, Michiko Okamoto, Asami Nakayama, Tetsuji Aoyagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　31　(6)　102714-102714　2025/06

DOI： 10.1016/j.jiac.2025.102714 　

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Cycle threshold (Ct) values obtained from real-time reverse-transcription polymerase chain reaction (RT-PCR) tests are commonly used to determine COVID-19 isolation discharge from hospitals. However, not all patients with low Ct values are infectious, and studies evaluating infectivity through virus cultures in Japan remain limited. This study assessed patients with Ct values <30 at 10 days after symptom onset and compared the clinical characteristics of seven patients with positive virus culture results and 11 patients with negative virus culture results to validate the Centers for Disease Control and Prevention (CDC) isolation criteria in Japan. Among non-immunosuppressed patients with mild-to-moderate COVID-19, 80 % were virus culture-negative 10 days after symptom onset, even when the Ct values were <30. In contrast, only 33 % of patients with severe-to-critical symptoms tested negative on virus culture. All immunosuppressed patients with severe-to-critical symptoms consistently tested positive in virus cultures. Notably, three patients with hematological disorders remained virus culture-positive 20 days after symptom onset. These findings generally align with the CDC criteria. For non-immunosuppressed patients with mild-to-moderate COVID-19, isolation release after 10 days is supported without the need for additional RT-PCR testing. However, for non-immunosuppressed patients with severe-to-critical symptoms and immunocompromised patients, particularly those with hematological disorders, isolation may be safely discontinued when Ct values exceed 30 after 10 days. This study provides valuable insights into identifying individuals suitable for isolation release based on SARS-CoV-2 testing in Japan.
抗HIV治療により寛解に至ったAIDS合併潰瘍性大腸炎の一例

粟田潤, 馬場啓聡, 清家一生, 中山麻美, 北村知穂, 武井健太郎, 大島謙吾, 青柳哲史

日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　99回・73回　O-252　2025/04
Publisher: 日本感染症学会・日本化学療法学会
Tsukamurella conjunctivitisにより引き起こされたカテーテル関連血流感染症の一例

北谷栞, 金森肇, 北村知穂, 武井健太郎, 馬場啓聡, 大島謙吾, 青柳哲史

日本臨床微生物学会雑誌　35　(Suppl.1)　348-348　2024/12
Publisher: (一社)日本臨床微生物学会
ISSN： 2434-866X
疥癬の医療従事者への院内感染事例

北村知穂, 千田貴恵, 遠藤春樹, 伊藤由佳, 千葉美紀子, 鈴木博也, 金森肇, 池田しのぶ, 徳田浩一, 青柳哲史

日本環境感染学会総会プログラム・抄録集　39回　376-376　2024/07
Publisher: (一社)日本環境感染学会
疥癬の医療従事者への院内感染事例

北村知穂, 千田貴恵, 遠藤春樹, 伊藤由佳, 千葉美紀子, 鈴木博也, 金森肇, 池田しのぶ, 徳田浩一, 青柳哲史

日本環境感染学会総会プログラム・抄録集　39回　376-376　2024/07
Publisher: (一社)日本環境感染学会
Undiagnosed Perihepatic Abscess Revealed at Autopsy of a Patient With COVID-19 Undergoing Prolonged Extracorporeal Membrane Oxygenation (ECMO) Therapy. International-journal

Issei Seike, Kengo Oshima, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi

Cureus　16　(4)　e58338　2024/04

DOI： 10.7759/cureus.58338 　

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The use of extracorporeal membrane oxygenation (ECMO) increased during the COVID-19 pandemic. However, complications associated with the long-term use of ECMO are poorly understood. This case report describes the autopsy findings of a perihepatic abscess in a patient with long-term COVID-19, which could not be diagnosed before death. In cases where the source of infection remains elusive but uncontrolled infections occur, we recommend the combined use of ultrasonography and contrast-enhanced computed tomography (CT) in patients with COVID-19 undergoing prolonged ECMO support, with particular consideration given to the potential development of cholecystitis.
Evaluation of the performance of GeneSoC®, a novel rapid real-time PCR system, to detect Staphylococcus aureus and methicillin resistance in blood cultures. International-journal

Mikiko Chiba, Tetsuji Aoyagi, Makiko Yoshida, Makoto Katsumi, Shin-Ichi Fujimaki, Yoshikazu Ishii, Kazuhiro Tateda, Mitsuo Kaku

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　29　(7)　718-721　2023/07

DOI： 10.1016/j.jiac.2023.03.006 　

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Staphylococcus aureus bacteremia results in substantial mortality. Rapid identification and the determination of methicillin susceptibility are crucial for immediate treatment with appropriate antibiotics. In the present study, we aimed to evaluate the basic assay performance of GeneSoC®, a novel rapid quantitative polymerase chain reaction (qPCR) method, for the detection of methicillin-susceptible (MS) or -resistant (MR) S. aureus in blood culture (BC) bottles. qPCR pimers and probes were desinged for femA and mecA genes to diagnose S. aureus and its methicilline-resistance status. GeneSoC® system can detect target genes within 12 min per sample using microfludic thermal cycling. A total of 100 BC-positive samples, showing clusters of gram-positive cocci using microscopy, were tested. The analytical sensitivity was demonstrated for the target sequence of femA and mecA genes at 10 copies/μL, respectively. The detection limit of the MRSA bacterial burden using this system was 104 and 103 CFU/mL for femA and mecA, respectively. Compared with culture-based identification and susceptibility testing, the sensitivity and specificity for the detection of femA (+)/mecA (+) MRSA using GeneSoC® were 90.9 and 98.9%, respectively, whereas the sensitivity and specificity for detection of femA (+)/mecA (-) MSSA were 96.2% and 97.3%, respectively. In conclusion, although this was a small sample and pilot study, the GeneSoC® system is beneficial for rapid, reliable, and highly sensitive real-time testing of MRSA and MSSA in BC bottles.
P.aeruginosa株におけるLPS遊離の条件探索

河村真人, 青柳哲史, 田村友梨奈, 高橋実央, 佐藤匠, 舘田一博, 藤村茂

日本化学療法学会雑誌　71　(4)　526-526　2023/07
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. International-journal

Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

Journal of clinical medicine　12　(10)　2023/05/14

DOI： 10.3390/jcm12103460 　

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Coronavirus disease 2019 (COVID-19) is associated with coagulopathy. However, the underlying mechanisms are not completely understood. We evaluated the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. We hypothesized that several EV levels would be higher in COVID-19 coagulopathy patients than in non-coagulopathy patients. This prospective observational study was conducted in four tertiary care faculties in Japan. We enrolled 99 COVID-19 patients (48 with coagulopathy and 51 without coagulopathy) aged ≥20 years who required hospitalization, and 10 healthy volunteers; we divided the patients into coagulopathy and non-coagulopathy groups according to the D-dimer levels (≥1 μg/mL and <1 μg/mL, respectively). We used flow cytometry to measure the tissue-factor-bearing, endothelium-derived, platelet-derived, monocyte-derived, and neutrophil-derived EV levels in platelet-free plasma. The EV levels were compared between the two COVID-19 groups as well as among the coagulopathy patients, non-coagulopathy patients, and healthy volunteers. No significant difference was found in EV levels between the two groups. Meanwhile, the cluster of differentiation (CD) 41 + EV levels were significantly higher in COVID-19 coagulopathy patients than in healthy volunteers (549.90 [255.05-984.65] vs. 184.3 [150.1-254.1] counts/µL, p = 0.011). Therefore, CD41+ EVs might play an essential role in COVID-19 coagulopathy development.
P.aeruginosa株におけるLPS遊離の条件探索

河村真人, 青柳哲史, 田村友梨奈, 高橋実央, 佐藤匠, 舘田一博, 藤村茂

日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　P-171　2023/03
Publisher: 日本感染症学会・日本化学療法学会
Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan. International-journal

Kengo Oshima, Chie Nakajima, Kazushige Hirata, Hironori Hayashi, Eiichi N Kodama, Yukari Fukushima, Yasuhiko Suzuki, Hajime Kanamori, Hiroaki Baba, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　28　(7)　965-970　2022/07

DOI： 10.1016/j.jiac.2022.02.008 　

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Tuberculosis remains a major public health concern. Millions of tuberculosis cases and associated deaths have been reported worldwide. The Indo-Oceanic lineage Mycobacterium tuberculosis is common in Southeast Asia and causes extrapulmonary lesions. Only a few case studies on this lineage with genetic analysis using whole-genome sequencing have been reported in the literature. We present a case of disseminated tuberculosis, characterized by a variety of extrapulmonary lesions and paradoxical reactions, caused by the Indo-Oceanic lineage M. tuberculosis in a woman in Myanmar. A 22-year-old Burmese woman had arthritis in the right knee, with unknown aetiology, and was referred to our hospital. Computed tomography of the trunk revealed multiple nodular shadows in both lungs; swollen mediastinal lymph nodes; and small, low-density areas in the spleen. M. tuberculosis was detected in the sputum sample, joint aspirate, subcutaneous tumor, and exudate. She experienced a variety of paradoxical reactions together with aggressive tuberculosis dissemination in all areas of the body. Whole-genome sequencing of the DNA of MTB obtained from sputum and the right cervical subcutaneous abscess confirmed the Indo-Oceanic lineage of M. tuberculosis, the predominant strain in Myanmar. The Indo-Oceanic lineage M. tuberculosis causes disseminated tuberculosis all over the body including the periungual region. When patients show unusual symptoms, physicians should consider the introduction of new strains from foreign countries. Genetic analyses of the strains are recommended to define and confirm the lineages.
Pseudomonas otitidisによる蜂窩織炎及び血流感染症を来した一例

森岳雄, 吉澤定子, 佐藤高広, 柏木克仁, 前田正, 山田景土, 佐々木雅一, 村上日奈子, 山口哲央, 青柳哲史, 石井良和, 舘田一博

感染症学雑誌　96　(臨増)　156-156　2022/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Maculopapular Rash in Japanese Patients with COVID-19.

Issei Seike, Hajime Kanamori, Kengo Oshima, Tetsuji Aoyagi

Internal medicine (Tokyo, Japan)　2022/02/01

DOI： 10.2169/internalmedicine.8491-21 　
Multiple Secondary Healthcare-Associated Infections Due to Carbapenem-Resistant Organisms in a Critically Ill COVID-19 Patient on Extensively Prolonged Venovenous Extracorporeal Membrane Oxygenation Support-A Case Report. International-journal

Hiroaki Baba, Hajime Kanamori, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Kengo Oshima, Yudai Iwasaki, Yuko Ogata, Hirona Nishimaki, Daisuke Konno, Takuya Shiga, Koji Saito, Koichi Tokuda, Tetsuji Aoyagi

Microorganisms　10　(1)　2021/12/23

DOI： 10.3390/microorganisms10010019 　

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Patients with severe Coronavirus disease 2019 (COVID-19) are at high risk for secondary infection with multidrug-resistant organisms (MDROs). Secondary infections contribute to a more severe clinical course and longer intensive care unit (ICU) stays in patients with COVID-19. A man in his 60s was admitted to the ICU at a university hospital for severe COVID-19 pneumonia requiring mechanical ventilation. His respiratory condition worsened further due to persistent bacteremia caused by imipenem-non-susceptible Klebsiella aerogenes and he required VV-ECMO. Subsequently, he developed a catheter-related bloodstream infection (CRBSI) due to Candida albicans, ventilator-associated pneumonia (VAP) due to multidrug-resistant Pseudomonas aeruginosa (MDRP), and a perianal abscess due to carbapenem-resistant K. aerogenes despite infection control procedures that maximized contact precautions and the absence of MDRO contamination in the patient's room environment. He was decannulated from VV-ECMO after a total of 72 days of ECMO support, and was eventually weaned off ventilator support and discharged from the ICU on day 138. This case highlights the challenges of preventing, diagnosing, and treating multidrug-resistant organisms and healthcare-associated infections (HAIs) in the critical care management of severe COVID-19. In addition to the stringent implementation of infection prevention measures, a high index of suspicion and a careful evaluation of HAIs are required in such patients.
Azithromycin: A promising treatment option for Mycobacterium avium complex pulmonary disease in case of intolerance to clarithromycin. International-journal

Kengo Oshima, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

Journal of clinical tuberculosis and other mycobacterial diseases　25　100274-100274　2021/12

DOI： 10.1016/j.jctube.2021.100274 　

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Macrolide-based combination chemotherapy is recommended for the treatment of Mycobacterium avium complex (MAC) pulmonary disease (MPD). The susceptibility of the MAC to macrolide antibiotics (MAs) determines the efficacy of treatment and clinical course of MPD. However, MAs cause several adverse effects, resulting in the discontinuation of macrolide-based combination chemotherapy. We encountered two women aged 65 years and 66 years diagnosed with MPD based on bronchoscopic examinations. They were initially treated with clarithromycin-based combination chemotherapy. However, neither patient could continue with chemotherapy owing to adverse events such as rash and edema. We switched clarithromycin with azithromycin, and the patients were able to continue chemotherapy without adverse events. Both patients completed their treatment successfully. Azithromycin, which also belongs to the class of MAs, can be a promising therapeutic option for MPD in case of clarithromycin intolerance.
Case Report: Successful Treatment of Five Critically Ill Coronavirus Disease 2019 Patients Using Combination Therapy With Etoposide and Corticosteroids International-journal

Tetsuji Aoyagi, Yukio Sato, Hiroaki Baba, Takuya Shiga, Issei Seike, Ikumi Niitsuma Sugaya, Kentarou Takei, Yudai Iwasaki, Kengo Oshima, Hajime Kanamori, Makiko Yoshida, Koji Saito, Koichi Tokuda, Mitsuo Kaku

Frontiers in Medicine　8　718641-718641　2021/09/23
Publisher: Frontiers Media SA
DOI： 10.3389/fmed.2021.718641 　

eISSN： 2296-858X

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Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) because of limited effective therapies. During infection, the accumulation and activation of macrophages and monocytes in the lungs induce inflammatory mediators and contribute to tissue injury, leading to ARDS. However, therapeutic strategies that directly target activated macrophage and monocytes have not been reported. Combination treatment with etoposide (a cytotoxic agent) and a corticosteroid has been widely used for treating hemophagocytic lymphohistiocytosis characterized by the systemic activation of macrophages with overwhelming inflammation. Herein, we present five cases of COVID-19-associated ARDS treated with etoposide and corticosteroids. Three of the five patients were over 65 years of age and had various underlying diseases, including multiple myeloma. Four patients required invasive mechanical ventilation (MV), and one patient refused to be placed on MV due to underlying diseases. All patients were pre-treated with antiviral and/or other anti-inflammatory agents, but their condition deteriorated and hyperinflammation was noted. All five patients responded well to treatment and had an immediate response, as reflected by improvement in their respiratory condition and inflammatory marker levels and rapid resolution of fever after etoposide administration; however, some patients required a second dose of etoposide and longer course of steroids. All patients recovered, and there were no severe adverse events related to the drugs. Following successful treatment in these five patients, we plan to conduct a clinical trial to evaluate the efficacy and safety of combination therapy with etoposide and corticosteroid for treating COVID-19 patients in Japan.
宮城県における侵襲性リステリア症の分子疫学的検討

馬場啓聡, 金森肇, 角田梨紗子, 桜井博毅, 大島謙吾, 青柳哲史, 賀来満夫

日本臨床腸内微生物学会誌　23　(1)　61-66　2021/06
Publisher: 日本臨床腸内微生物学会

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2006〜2019年の宮城県内の三次医療施設4施設における侵襲性リステリア症症例について後ろ向きに調査した。網羅的病原遺伝子解析の結果、検出された全18株のListeria monocytogenes中、血清型IVbが10株(55%)と最も多く、その内訳はIVb-CC6型が4株(22%)、IVb-CC1およびIVb-CC2がそれぞれ3株(17%)であった。病原遺伝子の分布はそれぞれの遺伝子型毎に特徴を認めたが、遺伝子型と疾患とに関係性は見られなかった。分子系統解析では、2007年に菌血症患者から検出された株と、2012年に感染性大動脈瘤(IAA)患者から検出された株、および2015年にIAA患者から検出された株と2017年に髄膜炎患者から検出された株はそれぞれ同じCT型(IVb-CT1およびIVb-CT6)に属し、それぞれ異なる遺伝子が10個以下と相同性が非常に高かった。NCBIデータベース上の株と、宮城県で得られた株計277株の中で、遺伝子型IVb-CC1・2・6型と、それ以外の遺伝子型の株との病原遺伝子の分布を比較した。その結果、IVb-CC1・2・6型株は細胞壁に存在し宿主細胞への接着に関与するタイコ酸合成遺伝子gltA・gltBおよびLIPI-3遺伝子や、宿主細胞への侵入に関わるaut_IVbやvipの各病原遺伝子を他の遺伝子型株に比べ有意に多く保有していた。分子系統解析では、2013年宮城県・胎内感染症例由来株と2003年ブラジル・ポークソーセージ由来株、1931年アメリカ合衆国・由来不明株と1961年イギリス・鶏由来株、アメリカ合衆国・採取年・由来不明株と2005年ロシア・Myodes rufocanus由来株の遺伝的相同性がそれぞれ非常に高かった。
Disseminated gonococcal infection in a patient with paroxysmal nocturnal haemoglobinuria receiving eculizumab. International-journal

Ikumi Niitsuma-Sugaya, Hajime Kanamori, Satoshi Ichikawa, Noriko Fukuhara, Issei Seike, Kentaro Takei, Hiroaki Baba, Kengo Oshima, Tetsuji Aoyagi, Hideo Harigae, Koichi Tokuda

The Lancet. Infectious diseases　21　(5)　741-741　2021/05

DOI： 10.1016/S1473-3099(20)30930-0 　
Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan. International-journal

Hiroaki Baba, Hajime Kanamori, Risako Kakuta, Hiroki Sakurai, Kengo Oshima, Tetsuji Aoyagi, Mitsuo Kaku

Diagnostic microbiology and infectious disease　99　(3)　115233-115233　2021/03

DOI： 10.1016/j.diagmicrobio.2020.115233 　

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We reviewed 18 listeriosis cases in Japan and performed molecular analysis of causative Listeria monocytogenes (LM) isolates. Strains genetically related to those from other countries caused various types of listeriosis, including vascular listeriosis in immunocompetent elderly people. Our results highlight the importance of integrated clinical and genomic analysis of LM.
Pulmonary infection caused by Mycobacterium marinum in a patient with anorexia nervosa. International-journal

Kengo Oshima, Yukari Niinuma, Hajime Saito, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

ERJ open research　7　(1)　2021/01

DOI： 10.1183/23120541.00782-2020 　

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Mycobacterium marinum can cause pulmonary infection and can grow at ≤32°C. Physicians should consider M. marinum when examining patients with pulmonary infection and low body temperature or anorexia nervosa, and grow the specimen at ≤32°C. https://bit.ly/3jkzBeq.
Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide. International-journal Peer-reviewed

Hiroaki Baba, Hajime Kanamori, Kengo Oshima, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Yukio Sato, Koichi Tokuda, Tetsuji Aoyagi

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　26　(10)　1100-1103　2020/10

DOI： 10.1016/j.jiac.2020.06.022 　

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We report a coronavirus disease 2019 (COVID-19) case with rheumatoid arthritis taking iguratimod. The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. The effects of disease-modifying antirheumatic drugs (DMARDs) and ciclesonide on clinical course and viral shedding remain unknown and warrant further investigation.
Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome

Tetsuji Aoyagi, Yukio Sato, Kazuyoshi Kawakami, Mitsuo Kaku

Japanese Journal of Chemotherapy　68　(5)　563-575　2020/09/01
Publisher: Japan Society of Chemotherapy
ISSN： 1340-7007
Chromobacterium haemolyticum Pneumonia Associated with Near-Drowning and River Water, Japan. International-journal Peer-reviewed

Hajime Kanamori, Tetsuji Aoyagi, Makoto Kuroda, Tsuyoshi Sekizuka, Makoto Katsumi, Kenichiro Ishikawa, Tatsuhiko Hosaka, Hiroaki Baba, Kengo Oshima, Koichi Tokuda, Masatsugu Hasegawa, Yu Kawazoe, Shigeki Kushimoto, Mitsuo Kaku

Emerging infectious diseases　26　(9)　2186-2189　2020/09

DOI： 10.3201/eid2609.190670 　

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We report a severe case of Chromobacterium haemolyticum pneumonia associated with near-drowning and detail the investigation of the pathogen and river water. Our genomic and environmental investigation demonstrated that river water in a temperate region can be a source of C. haemolyticum causing human infections.
Screening of COVID-19-associated hypercoagulopathy using rotational thromboelastometry. International-journal Peer-reviewed

Yudai Iwasaki, Takuya Shiga, Daisuke Konno, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Koichi Tokuda, Masanori Yamauchi

Journal of clinical anesthesia　67　109976-109976　2020/07/04

DOI： 10.1016/j.jclinane.2020.109976 　
Characterization of Ba813 harbouring Bacillus cereus in patients with haematological malignancy and hospital environments at a medical centre in Japan. International-journal Peer-reviewed

Tetsuji Aoyagi, Yasuhiro Kishihara, Miho Ogawa, Yuki Ito, Sakie Tanaka, Ryozo Kobayashi, Koichi Tokuda, Mistuo Kaku

Journal of medical microbiology　69　(7)　999-1004　2020/07

DOI： 10.1099/jmm.0.001212 　

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Introduction.Bacillus cereus harbouring Ba813, a specific chromosomal marker of Bacillus anthtacis, is found in patients with severe manifestations and causes nosocomial outbreaks.Aim. We assessed the genetic characteristics and virulence of Ba813(+) B. cereus in a hospital setting.Methodology. Three neutropenic patients with haematological malignancy developed B. cereus bacteraemia within a short period. Fifteen B. cereus were isolated from different sites in a haematology ward. A total of 18 isolates were evaluated for Ba813- and B. anthracis-related virulence, food poisoning-related virulence, genetic diversity, bacteria motility and biofilm formation.Results.Ba813(+) B. cereus was detected in 33 % (1/3) of patients and 66 % (9/15) of the hospital environment. The 18 strains were divided into 2 major clusters (clade 1 and clade 2), and 14 strains were classified into clade 1. All Ba813(+) strains, including four sequence types, were classified into clade 1/the cereus III lineage, which is most closely related to the anthracis lineage. Two strains belonging to clade 1/non-cereus III carried the B. anthracis-associated cap gene, but not Ba813. B. cereus, including Ba813(+) strains, had significantly lower prevalence of enterotoxin genes than clade 2 strains. In clade 1, B. cereus, Ba813(+) strains showed significantly higher swimming motility and biofilm formation ability than Ba813(-) strains.Conclusion.Ba813(+) B. cereus, which are genetically closely related to B. anthracis, were abundant in a haematological ward. Ba813(+) B. cereus with high motility and biofilm formation abilities may spread easily in hospital environments, and could become a hospital-acquired infection.
Ba813 harboring Bacillus cereus, genetically closely related to Bacillus anthracis, causing nosocomial bloodstream infection: Bacterial virulence factors and clinical outcome. International-journal Peer-reviewed

Tetsuji Aoyagi, Kengo Oshima, Shiro Endo, Hiroaki Baba, Hajime Kanamori, Makiko Yoshida, Koichi Tokuda, Mitsuo Kaku

PloS one　15　(7)　e0235771　2020

DOI： 10.1371/journal.pone.0235771 　

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Bacillus cereus commonly causes catheter-related bloodstream infections (BSIs) in hospital settings, and occasionally occurs fatal central nervous system (CNS) complications. B. cereus harboring Ba813, a specific chromosomal marker of Bacillus anthracis, has been found in patients with severe infection and nosocomial BSI. However, the bacteriological profile and clinical feature of Ba813 (+) B. cereus are unclear. Fifty-three patients with B. cereus BSI were examined. Isolates were evaluated for Ba813, B. anthracis-related and food poisoning-related virulence, multilocus sequencing typing, and biofilm formation. Patients' clinical records were reviewed retrospectively. The 53 isolates were comprised of 29 different sequence types in two distinct clades. Seventeen of the 53 (32%) B. cereus isolates including five sequence types possessed Ba813 and were classified into Clade-1/Cereus-III lineage which is most closely related to Anthracis lineage. No B. cereus possessed B. anthracis-related virulence genes. Ba813 (+) strains showed a lower prevalence of enterotoxin genes than Clade-2 strains (n = 4), but no difference from Clade-1. Ba813 (+) strains showed significantly lower biofilm formation than Clade-1/non-Cereus-III (n = 22) and Clade-2 strains, respectively. Compared to Clade-1/non-Cereus-III and Clade-2 B. cereus, Ba813 (+) strains were isolated more frequently from elderly patients, patients with indwelling central venous catheter rather than peripheral venous catheter, and patients who remained in the hospital for longer before BSI onset. No significant differences in disease severity or mortality were observed. Though two of the ten Ba813 (-) strains in Clade-1/Cereus III were isolated from the patients with CNS complication, no significant difference was observed in the bacterial profile and clinical characteristics among Clade-1/Cereus III strains. In conclusion, our report suggested that Ba813-harboring B. cereus strains, genetically closely related to B. anthracis, were abundant among B. cereus strains in the hospital setting, and might cause catheter-related nosocomial BSI. However, it did not affect the clinical outcomes.
The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility. International-journal Peer-reviewed

Hiroyuki Kunishima, Noriomi Ishibashi, Kaoruko Wada, Kentaro Oka, Motomichi Takahashi, Yukitaka Yamasaki, Tetsuji Aoyagi, Hiromu Takemura, Miho Kitagawa, Mitsuo Kaku

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　25　(11)　894-900　2019/11

DOI： 10.1016/j.jiac.2019.04.021 　

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The gut microbiota may play a pivotal role in controlling the antimicrobial resistant (AMR) organisms although the evidences are limited. We investigated the effects of gut microbiota on the growth of AMR organisms, β-lactamases activity and transmissibility of antimicrobial resistant properties of the extended spectrum β-lactamase (ESBL)-producing Escherichia coli and carbapenem-resistant Enterobacteriaceae. CTX-M-15-positive, ESBL-producing E. coli and carbapenem resistant Enterobacteriaceae, Bacteroides fragilis, Bifidobacterium longum, Clostridium butyricum, Clostridioides difficile, Clostridium perfringens, Enterococcus faecium, Lactobacillus plantarum and probiotic strain of C. butyricum MIYAIRI 588 were used in this study. The growth of AMR organisms was suppressed by the supernatant of C. butyricum, C. difficile, C. perfringens, E. faecium and L. plantarum in a dose dependent manner but not by that of B. fragilis and B. longum. The β-lactamase activity produced by E. coli was reduced by the presence of culture supernatant of certain gut microbiota during stationary phase of E. coli. Importantly, C. butyricum MIYAIRI 588 culture supernatant suppressed the transcription of blaCTX-M gene during growth phase of E. coli. The conjugation assay showed the reduction of transmissibility of antibiotic resistant gene by gut microbiota. These findings suggest that certain gut microbiota affect the antibiotic resistant activities of AMR organisms. Further studies are needed to identify the specific mechanism(s) of these actions between AMR organisms and gut microbiota.
Etoposide and Corticosteroid Combination Therapy Improves Acute Respiratory Distress Syndrome in Mice. International-journal Peer-reviewed

Tetsuji Aoyagi, Yukio Sato, Masahiko Toyama, Kengo Oshima, Kazuyoshi Kawakami, Mistuo Kaku

Shock (Augusta, Ga.)　52　(1)　83-91　2019/07

DOI： 10.1097/SHK.0000000000001231 　

ISSN： 1073-2322

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Excessive inflammation reactions with a cytokine storm in the lungs have historically been thought as the primary cause of fatal acute respiratory distress syndrome (ARDS). However, interruption of inflammatory cytokine activation failed to attenuate ARDS, suggesting that other therapies are required to treat this illness and improve survival. Etoposide (ET), a cytotoxic agent, and prednisolone (PSL), a corticosteroid with strong anti-inflammatory activity, have been used to treat other disease involving similar cytokine-activated macrophages and hemophagocytic activity. However, they have not been previously tested as ARDS therapeutics alone or in combination. In the present study, we used a fatal ARDS mouse model induced via administration of α-galactosylceramide and lipopolysaccharide, which resulted in the development of severe lung injury with hypercytokinemia and hemophagocytosis, all of which were observed in ARDS patients infected with highly pathogenic respiratory viruses. The ET and PSL combination therapy, but not ET or PSL alone, reduced the recruitment and activation of inflammatory cells including macrophages, natural killer T cells, and neutrophils, and significantly improved the survival rate in this model. Furthermore, whereas ET alone improved lung edema, it did not increase the survival rate, indicating the necessity of PSL in the treatment of ARDS. Surprisingly, combination therapy did not reduce the production of cytokines and chemokines in the lungs, demonstrating that inflammatory cells, rather than hypercytokinemia, are the direct target of these compounds and primary cause of ARDS-related death. Thus, combination therapy with ET and PSL that targets inflammatory cells has the potential to attenuate fatal ARDS.
Mutant selection window of disinfectants for Staphylococcus aureus and Pseudomonas aeruginosa. International-journal Peer-reviewed

Masato Kawamura, Shigeru Fujimura, Koichi Tokuda, Tetsuji Aoyagi, Shiro Endo, Hajime Kanamori, Akira Watanabe, Mitsuo Kaku

Journal of global antimicrobial resistance　17　316-320　2019/06

DOI： 10.1016/j.jgar.2019.01.015 　

ISSN： 2213-7165

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OBJECTIVES: The aim of this study was to determine the mutant selection window (MSW) of various disinfectants against Staphylococcus aureus and Pseudomonas aeruginosa clinical isolates to determine the tendency of these strains to acquire resistance to disinfectants. METHODS: A total of 60 S. aureus isolates [30 methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA)] and 30 P. aeruginosa, including 2 multidrug-resistant P. aeruginosa (MDRP), were collected in Japan. The minimum inhibitory concentrations (MICs) and mutant prevention concentrations (MPCs) of disinfectants, including sodium hypochlorite (NaOCl), against these strains were established to determine the MSW. RESULTS: The MSW50, MSW80 and MSW100 for sodium hypochlorite against S. aureus and P. aeruginosa were 4×, 8× and 16× MIC, respectively. Strains surviving in the sodium hypochlorite MSW remained at a concentration of ≤0.3% (≤3072μg/mL). CONCLUSIONS: This is the first evaluation of the bactericidal activity against S. aureus and P. aeruginosa strains surviving in the MSW of disinfectants. Environmental disinfection at low concentrations of sodium hypochlorite does not kill micro-organisms. Proper use of sodium hypochlorite shows a bactericidal effect against various pathogenic micro-organisms and is inexpensive, making it frequently used globally.
Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan. International-journal Peer-reviewed

Hiroaki Baba, Hajime Kanamori, Hayami Kudo, Yasutoshi Kuroki, Seiya Higashi, Kentaro Oka, Motomichi Takahashi, Makiko Yoshida, Kengo Oshima, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

PloS one　14　(11)　e0225340　2019

DOI： 10.1371/journal.pone.0225340 　

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Shiga toxin-producing Escherichia coli (STEC) can cause severe gastrointestinal disease and colonization among food handlers. In Japan, STEC infection is a notifiable disease, and food handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of STEC is not entirely known. We investigated the genomic characteristics of STEC from patients and asymptomatic food handlers in Miyagi Prefecture, Japan. Whole-genome sequencing (WGS) was performed on 65 STEC isolates obtained from 38 patients and 27 food handlers by public health surveillance in Miyagi Prefecture between April 2016 and March 2017. Isolates of O157:H7 ST11 and O26:H11 ST21 were predominant (n = 19, 29%, respectively). Non-O157 isolates accounted for 69% (n = 45) of all isolates. Among 48 isolates with serotypes found in the patients (serotype O157:H7 and 5 non-O157 serotypes, O26:H11, O103:H2, O103:H8, O121:H19 and O145:H28), adhesion genes eae, tir, and espB, and type III secretion system genes espA, espJ, nleA, nleB, and nleC were detected in 41 to 47 isolates (85-98%), whereas isolates with other serotypes found only in food handlers were negative for all of these genes. Non-O157 isolates were especially prevalent among patients younger than 5 years old. Shiga-toxin gene stx1a, adhesion gene efa1, secretion system genes espF and cif, and fimbrial gene lpfA were significantly more frequent among non-O157 isolates from patients than among O157 isolates from patients. The most prevalent resistance genes among our STEC isolates were aminoglycoside resistance genes, followed by sulfamethoxazole/trimethoprim resistance genes. WGS revealed that 20 isolates were divided into 9 indistinguishable core genomes (<5 SNPs), demonstrating clonal expansion of these STEC strains in our region, including an O26:H11 strain with stx1a+stx2a. Non-O157 STEC with multiple virulence genes were prevalent among both patients and food handlers in our region of Japan, highlighting the importance of monitoring the genomic characteristics of STEC.
Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia. International-journal Peer-reviewed

Yuta Nanjo, Michael W Newstead, Tetsuji Aoyagi, Xianying Zeng, Kazuhisa Takahashi, Fu Shin Yu, Kazuhiro Tateda, Theodore J Standiford

Infection and immunity　87　(1)　2019/01

DOI： 10.1128/IAI.00583-18 　

ISSN： 0019-9567

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Legionella pneumophila causes life-threatening pneumonia culminating in acute lung injury. Innate and adaptive cytokines play an important role in host defense against L. pneumophila infection. Interleukin-36 (IL-36) cytokines are recently described members of the larger IL-1 cytokine family known to exert potent inflammatory effects. In this study, we elucidated the role for IL-36 cytokines in experimental pneumonia caused by L. pneumophila Intratracheal (i.t.) administration of L. pneumophila induced the upregulation of both IL-36α and IL-36γ mRNA and protein production in the lung. Compared to the findings for L. pneumophila-infected wild-type (WT) mice, the i.t. administration of L. pneumophila to IL-36 receptor-deficient (IL-36R-/-) mice resulted in increased mortality, a delay in lung bacterial clearance, increased L. pneumophila dissemination to extrapulmonary organs, and impaired glucose homeostasis. Impaired lung bacterial clearance in IL-36R-/- mice was associated with a significantly reduced accumulation of inflammatory cells and the decreased production of proinflammatory cytokines and chemokines. Ex vivo, reduced expression of costimulatory molecules and impaired M1 polarization were observed in alveolar macrophages isolated from infected IL-36R-/- mice compared to macrophages from WT mice. While L. pneumophila-induced mortality in IL-36α- or IL-36γ-deficient mice was not different from that in WT animals, antibody-mediated neutralization of IL-36γ in IL-36α-/- mice resulted in mortality similar to that observed in IL-36R-/- mice, indicating redundant and overlapping roles for these cytokines in experimental murine L. pneumophila pneumonia.
Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature. International-journal Peer-reviewed

Kiwamu Nakamura, Kyoichi Saito, Yasuka Hara, Tetsuji Aoyagi, Kadzuhiro Kitakawa, Yoshinobu Abe, Hiromu Takemura, Fumihito Ikeda, Mitsuo Kaku, Keiji Kanemitsu

BMC infectious diseases　18　(1)　381-381　2018/08/07

DOI： 10.1186/s12879-018-3284-5 　

ISSN： 1471-2334
Attenuated accumulation of regulatory T cells and reduced production of interleukin 10 lead to the exacerbation of tissue injury in a mouse model of acute respiratory distress syndrome. International-journal Peer-reviewed

Masahiko Toyama, Daisuke Kudo, Tetsuji Aoyagi, Tomomitsu Miyasaka, Keiko Ishii, Emi Kanno, Mitsuo Kaku, Shigeki Kushimoto, Kazuyoshi Kawakami

Microbiology and immunology　62　(2)　111-123　2018/02

DOI： 10.1111/1348-0421.12564 　

ISSN： 0385-5600
Evaluation of ozonated water using ASTM E1174 for standardized testing of handwash formulations for healthcare personnel Peer-reviewed

K. Nakamura, K. Saito, J. Kashiwazaki, T. Aoyagi, K. Arai, Y. Hara, S. Kobari, H. Mori, K. Ohashi, Y. Takano, M. Kaku, K. Kanemitsu

Journal of Hospital Infection　2018
Publisher: W.B. Saunders Ltd
DOI： 10.1016/j.jhin.2018.02.009 　

ISSN： 1532-2939 0195-6701
Spread of mcr-1.5 in the community: an emerging threat. International-journal Peer-reviewed

Yoshikazu Ishii, Kotaro Aoki, Shiro Endo, Hiroshi Kiyota, Tetsuji Aoyagi, Mitsuo Kaku, Robert A Bonomo, Kazuhiro Tateda

International journal of antimicrobial agents　51　(1)　161-162　2018/01

DOI： 10.1016/j.ijantimicag.2017.10.015 　

ISSN： 1872-7913 0924-8579
Interleukin-36γ and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2. International-journal Peer-reviewed

Tetsuji Aoyagi, Michael W Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J Standiford

PLoS pathogens　13　(11)　e1006737　2017/11

DOI： 10.1371/journal.ppat.1006737 　

ISSN： 1553-7366

eISSN： 1553-7374
The first case report of septic abortion resulting from β-lactamase-negative ampicillin-resistant non-typeable Haemophilus influenzae infection. International-journal Peer-reviewed

Hiroaki Baba, Risako Kakuta, Hasumi Tomita, Minako Miyazoe, Masatoshi Saito, Chihiro Oe, Noriomi Ishibashi, Misa Sogi, Kengo Oshima, Tetsuji Aoyagi, Yoshiaki Gu, Makiko Yoshida, Koichi Tokuda, Shiro Endo, Hisakazu Yano, Mitsuo Kaku

JMM case reports　4　(10)　e005123　2017/10

DOI： 10.1099/jmmcr.0.005123 　

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Introduction. This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable Haemophilus influenzae infection. In Japan, BLNAR H. influenzae is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but H. influenzae has not been previously recognized as a causative agent of obstetric or gynaecological infection. Case presentation. A 31-year-old pregnant woman presented at 17 weeks and 6 days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery. Despite tocolytic treatment, she aborted spontaneously 2 h after admission and then entered septic shock. BLNAR H. influenzae was detected in both blood and vaginal cultures. Her condition gradually improved after several days of treatment with cefotaxime, and she was ultimately discharged without sequelae or complaints. Conclusion. Although penicillin with a β-lactamase inhibitor is currently recommended for the treatment of septic abortion, this combination will probably lead to treatment failure in the case of BLNAR H. influenzae infection. As this study reveals, H. influenzae can cause septic abortion; hence, future efforts should be undertaken to detect and therapeutically target this pathogen during pregnancy.
IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia Peer-reviewed

T. Aoyagi, M. W. Newstead, X. Zeng, S. L. Kunkel, M. Kaku, T. J. Standiford

Mucosal Immunology　10　(4)　1043-1055　2017/07/01
Publisher: Nature Publishing Group
DOI： 10.1038/mi.2016.107 　

ISSN： 1935-3456 1933-0219
Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: Disease characteristics and serotype distribution Peer-reviewed

Munehisa Fukusumi, the Adult IPD Study Group, Bin Chang, Yoshinari Tanabe, Kengo Oshima, Takaya Maruyama, Hiroshi Watanabe, Koji Kuronuma, Kei Kasahara, Hiroaki Takeda, Junichiro Nishi, Jiro Fujita, Tetsuya Kubota, Tomimasa Sunagawa, Tamano Matsui, Kazunori Oishi, Michiharu Nakano, Tasuya Ikeda, Yu Suzuki, Junji Seto, Kazue Yahagi, Kurumi Kazama, Satoru Yamazaki, Emiko Kumakura, Minoru Hiraoka, Yuhki Nagai, Sagako Naraya, Eri Tsujimoto, Michiaki Matsumoto, Hiroaki Shigemura, Fuyuki Okamoto, Nobuyuki Sera, Mutsuyo Gokuden, Toru Itokazu, Akihito Yokoyama, Hiroki Takahashi, Tetsuji Aoyagi, Takuri Takahashi

BMC Infectious Diseases　17　(1)　2017/01/03
Publisher: BioMed Central Ltd.
DOI： 10.1186/s12879-016-2113-y 　

ISSN： 1471-2334
Pertussis outbreak among patients and healthcare workers in a provincial dialysis facility in Japan Peer-reviewed

K. Nakamura, M. Kobayashi, N. Yamamoto, K. Tokuda, S. Miura, Y. Abe, J. Kashiwazaki, T. Aoyagi, M. Kaku, K. Kanemitsu

Journal of Hospital Infection　94　(4)　341-345　2016/12/01
Publisher: W.B. Saunders Ltd
DOI： 10.1016/j.jhin.2016.09.011 　

ISSN： 1532-2939 0195-6701
Invasive liver abscess syndrome caused by Klebsiella pneumoniae with definite K2 serotyping in Japan: a case report. International-journal Peer-reviewed

Ryota Seo, Daisuke Kudo, Yoshiaki Gu, Hisakazu Yano, Tetsuji Aoyagi, Taku Omura, Shigemi Irino, Mitsuo Kaku, Shigeki Kushimoto

Surgical case reports　2　(1)　72-72　2016/12

DOI： 10.1186/s40792-016-0201-2 　

ISSN： 2198-7793
Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis. International-journal Peer-reviewed

Kenichi Ishii, Fumiaki Tabuchi, Miki Matsuo, Keita Tatsuno, Tomoaki Sato, Mitsuhiro Okazaki, Hiroshi Hamamoto, Yasuhiko Matsumoto, Chikara Kaito, Tetsuji Aoyagi, Keiichi Hiramatsu, Mitsuo Kaku, Kyoji Moriya, Kazuhisa Sekimizu

Scientific reports　5　17092-17092　2015/11/25

DOI： 10.1038/srep17092 　

ISSN： 2045-2322
First confirmed case of spondylodiscitis with epidural abscess caused by Parvimonas micra. International-journal Peer-reviewed

Shiro Endo, Tadanobu Nemoto, Hisakazu Yano, Risako Kakuta, Hajime Kanamori, Shinya Inomata, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Miho Kitagawa, Mitsuo Kaku

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　21　(11)　828-30　2015/11

DOI： 10.1016/j.jiac.2015.06.002 　

ISSN： 1341-321X

eISSN： 1437-7780
Microbiological and molecular epidemiological analyses of community-associated methicillin-resistant Staphylococcus aureus at a tertiary care hospital in Japan. International-journal Peer-reviewed

Shinya Inomata, Hisakazu Yano, Koichi Tokuda, Hajime Kanamori, Shiro Endo, Chiyuki Ishizawa, Miho Ogawa, Sadahiro Ichimura, Masahiro Shimojima, Risako Kakuta, Daiki Ozawa, Tetsuji Aoyagi, Yoshiaki Gu, Masumitsu Hatta, Kengo Oshima, Kazutoshi Nakashima, Mitsuo Kaku

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　21　(10)　729-36　2015/10

DOI： 10.1016/j.jiac.2015.07.005 　

ISSN： 1341-321X

eISSN： 1437-7780
Prevalence of Smqnr and plasmid-mediated quinolone resistance determinants in clinical isolates of Stenotrophomonas maltophilia from Japan: Novel variants of Smqnr Peer-reviewed

H. Kanamori, H. Yano, A. Tanouchi, R. Kakuta, S. Endo, S. Ichimura, M. Ogawa, M. Shimojima, S. Inomata, D. Ozawa, T. Aoyagi, D. J. Weber, M. Kaku

New Microbes and New Infections　7　8-14　2015/09/01
Publisher: Elsevier Ltd
DOI： 10.1016/j.nmni.2015.04.009 　

ISSN： 2052-2975
A case of culture-negative endocarditis due to Streptococcus tigurinus Peer-reviewed

Hajime Kanamori, Risako Kakuta, Hisakazu Yano, Tomoyuki Suzuki, Yoshiaki Gu, Chihiro Oe, Shinya Inomata, Tetsuji Aoyagi, Masumitsu Hatta, Shiro Endo, Koichi Tokuda, David J. Weber, Yasuhiro Nakamura, Yoshikatsu Saiki, Mitsuo Kaku

JOURNAL OF INFECTION AND CHEMOTHERAPY　21　(1-2)　138-140　2015/01

DOI： 10.1016/j.jiac.2014.08.014 　

ISSN： 1341-321X

eISSN： 1437-7780
Helicobacter cinaedi infection of abdominal aortic aneurysm, Japan. International-journal Peer-reviewed

Risako Kakuta, Hisakazu Yano, Hajime Kanamori, Takuya Shimizu, Yoshiaki Gu, Masumitsu Hatta, Tetsuji Aoyagi, Shiro Endo, Shinya Inomata, Chihiro Oe, Koichi Tokuda, Daiki Ozawa, Hitoshi Goto, Yukio Katori, Mitsuo Kaku

Emerging infectious diseases　20　(11)　1942-5　2014/11

DOI： 10.3201/eid2011.140440 　

ISSN： 1080-6040

eISSN： 1080-6059
Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital Peer-reviewed

Hajime Kanamori, Koichi Tokuda, Shinobu Ikeda, Shiro Endo, Chiyuki Ishizawa, Yukari Hirai, Masami Takahashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Cu, Hisakazu Yano, David J. Weber, Mitsuo Kaku

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　234　(2)　111-116　2014/10

DOI： 10.1620/tjem.234.111 　

ISSN： 0040-8727

eISSN： 1349-3329
Impact of psm-mec in the Mobile Genetic Element on the Clinical Characteristics and Outcome of SCCmec-II Methicillin-resistant Staphylococcus aureus Bacteremia in Japan Peer-reviewed

Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M

Clinical Microbiology and Infection　20　(9)　912-919　2014/09

DOI： 10.1111/1469-0691.12575 　

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BACKGROUND: Over-expression of alpha-phenol-soluble modulins (PSMs) result in high virulence of community-associated methicillin-resistant Staphylococcus aureus (MRSA). The psm-mec gene, located in the mobile genetic element SCCmec-II, suppresses PSMαs production. METHODS: Fifty-two patients with MRSA bacteremia were enrolled. MRSA isolates were evaluated with regard to the psm-mec gene sequence, bacterial virulence, and the minimum inhibitory concentration (MIC) of vancomycin and teicoplanin. Fifty-one MRSA isolates were classified as SCCmec-II, and 10 had one point mutation in the psm-mec promoter. We compared clinical characteristics and outcomes between mutant MRSA and wild-type MRSA. RESULTS: Production of PSMα3 in mutant MRSA was significantly increased, but biofilm formation was suppressed. Wild-type MRSA caused more catheter-related bloodstream infections (30/41 vs. 3/10, P = 0.0028), whereas mutant MRSA formed more deep abscesses (4/10 vs. 3/41, P = 0.035). Bacteremia caused by mutant MRSA was associated with reduced 30-day mortality (1/10 vs. 13/41, P = 0.25), although this difference was not significant. The MIC90 of teicoplanin was higher for wild-type MRSA (1.5 mg/L vs. 1 mg/L), but the MIC of vancomycin was not different between the two groups. The 30-day mortality of MRSA with a high MIC of teicoplanin (≥1.5 mg/L) was higher than that of strains with a lower MIC (≤0.75 mg/L) (6/10 vs. 6/33, P = 0.017). CONCLUSION: Mutation of the psm-mec promoter contributes to virulence of SCCmec-II MRSA, and the product of psm-mec may determine the clinical characteristics of bacteremia caused by SCCmec-II MRSA, but it does not affect mortality.
A survey conducted immediately after the 2011 Great East Japan Earthquake: Evaluation of infectious risks associated with sanitary conditions in evacuation centers Peer-reviewed

Koichi Tokuda, Hiroyuki Kunishima, Yoshiaki Gu, Shiro Endo, Masumitsu Hatta, Hajime Kanamori, Tetsuji Aoyagi, Noriomi Ishibashi, Shinya Inomata, Hisakazu Yano, Miho Kitagawa, Mitsuo Kaku

JOURNAL OF INFECTION AND CHEMOTHERAPY　20　(7-8)　498-501　2014/07

DOI： 10.1016/j.jiac.2014.04.012 　

ISSN： 1341-321X

eISSN： 1437-7780
High Frequency of Acinetobacter soli among Acinetobacter Isolates Causing Bacteremia at a Tertiary Hospital in Japan Peer-reviewed

Shiro Endo, Hisakazu Yano, Hajime Kanamori, Shinya Inomata, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Koichi Tokuda, Miho Kitagawa, Mitsuo Kaku

JOURNAL OF CLINICAL MICROBIOLOGY　52　(3)　911-915　2014/03

DOI： 10.1128/JCM.03009-13 　

ISSN： 0095-1137

eISSN： 1098-660X
Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome Peer-reviewed

Kudo, D, Toyama, M, Aoyagi, T, Akahori, Y, Yamamoto, H, Ishii, K, Kanno, E, Maruyama, R, Kaku, M, Kushimoto, S, Kawakami K

Clinical and Experimental Immunology　173　276-287　2013/08

DOI： 10.1111/cei.12106 　

ISSN： 1365-2249
Low-dose Interferon-alpha Treatment Improves Survival and Inflammatory Responses in a Mouse Model of Fulminant Acute Respiratory Distress Syndrome Peer-reviewed

Daisuke Kudo, Kazuko Uno, Tetsuji Aoyagi, Yukiko Akahori, Keiko Ishii, Emi Kanno, Ryoko Maruyama, Shigeki Kushimoto, Mitsuo Kaku, Kazuyoshi Kawakami

INFLAMMATION　36　(4)　812-820　2013/08

DOI： 10.1007/s10753-013-9607-1 　

ISSN： 0360-3997
Tuberculosis Exposure among Evacuees at a Shelter after Earthquake, Japan, 2011 Peer-reviewed

Hajime Kanamori, Noboru Aso, Satoko Tadano, Miyoko Saito, Hiroo Saito, Bine Uchiyama, Noriomi Ishibashi, Shinya Inomata, Shiro Endo, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Yoshiaki Gu, Koichi Tokuda, Hisakazu Yano, Hiroyuki Kunishima, Yoichi Hirakata, Takao Saijyo, Miho Kitagawa, Mitsuo Kaku

EMERGING INFECTIOUS DISEASES　19　(5)　799-801　2013/05

DOI： 10.3201/eid1905.121137 　

ISSN： 1080-6040

eISSN： 1080-6059
Molecular Characteristics of Extended-Spectrum beta-Lactamases in Clinical Isolates from Escherichia coli at a Japanese Tertiary Hospital Peer-reviewed

Hisakazu Yano, Mina Uemura, Shiro Endo, Hajime Kanamori, Shinya Inomata, Risako Kakuta, Sadahiro Ichimura, Miho Ogawa, Masahiro Shimojima, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

PLOS ONE　8　(5)　2013/05

DOI： 10.1371/journal.pone.0064359 　

ISSN： 1932-6203
Characteristics of Infectious Diseases in Hospitalized Patients During the Early Phase After the 2011 Great East Japan Earthquake Pneumonia as a Significant Reason for Hospital Care Peer-reviewed

Tetsuji Aoyagi, Mitsuhiro Yamada, Hiroyuki Kunishima, Koichi Tokuda, Hisakazu Yano, Noriomi Ishibashi, Masumitsu Hatta, Shiro Endo, Kazuaki Arai, Shinya Inomata, Yoshiaki Gu, Hajime Kanamori, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

CHEST　143　(2)　349-356　2013/02

DOI： 10.1378/chest.11-3298 　

ISSN： 0012-3692
IMP-1-producing carbapenem-resistant Acinetobacter ursingii from Japan Peer-reviewed

Shiro Endo, Mina Sasano, Hisakazu Yano, Shinya Inomata, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Miho Kitagawa, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY　67　(10)　2533-2534　2012/10

DOI： 10.1093/jac/dks249 　

ISSN： 0305-7453
High Frequency of IMP-6 among Clinical Isolates of Metallo-beta-Lactamase-Producing Escherichia coli in Japan Peer-reviewed

Hisakazu Yano, Miho Ogawa, Shiro Endo, Risako Kakuta, Hajime Kanamori, Shinya Inomata, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　56　(8)　4554-4555　2012/08

DOI： 10.1128/AAC.00617-12 　

ISSN： 0066-4804
Molecular epidemiology of carbapenem-non-susceptible Acinetobacter baumannii in Japan Peer-reviewed

Shiro Endo, Hisakazu Yano, Yoichi Hirakata, Kazuaki Arai, Hajime Kanamori, Miho Ogawa, Masahiro Shimojima, Noriomi Ishibashi, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Koichi Tokuda, Miho Kitagawa, Hiroyuki Kunishima, Mitsuo Kaku

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY　67　(7)　1623-1626　2012/07

DOI： 10.1093/jac/dks094 　

ISSN： 0305-7453
Molecular Characteristics of Extended-Spectrum Beta-Lactamases and qnr Determinants in Enterobacter Species from Japan Peer-reviewed

Hajime Kanamori, Hisakazu Yano, Yoichi Hirakata, Ayako Hirotani, Kazuaki Arai, Shiro Endo, Sadahiro Ichimura, Miho Ogawa, Masahiro Shimojima, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Yoshiaki Gu, Koichi Tokuda, Hiroyuki Kunishima, Miho Kitagawa, Mitsuo Kaku

PLOS ONE　7　(6)　2012/06

DOI： 10.1371/journal.pone.0037967 　

ISSN： 1932-6203
First Carbapenem-Resistant Isolates of Acinetobacter soli in Japan Peer-reviewed

Shiro Endo, Mina Sasano, Hisakazu Yano, Kazuaki Arai, Tetsuji Aoyagi, Masumitsu Hatta, Yoshiaki Gu, Mitsuhiro Yamada, Koichi Tokuda, Miho Ogawa, Masahiro Shimojima, Miho Kitagawa, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY　56　(5)　2786-2787　2012/05

DOI： 10.1128/AAC.00021-12 　

ISSN： 0066-4804
A possible relationship of natural killer T cells with humoral immune response to 23-valent pneumococcal polysaccharide vaccine in clinical settings Peer-reviewed

Tomomitsu Miyasaka, Tetsuji Aoyagi, Binei Uchiyama, Kazunori Oishi, Toshinori Nakayama, Yuki Kinjo, Yoshitsugu Miyazaki, Hiroyuki Kunishima, Yoichi Hirakata, Mitsuo Kaku, Kazuyoshi Kawakami

VACCINE　30　(22)　3304-3310　2012/05

DOI： 10.1016/j.vaccine.2012.03.007 　

ISSN： 0264-410X
Role of Dectin-2 in the host defense against Streptococcus pneumoniae infection Peer-reviewed

Keiko Ishii, Yukiko Akahori, Masahiko Toyama, Tetsuji Aoyagi, Natsuo Yamamoto, Shinobu Saijo, Yoichiro Iwakura, Sho Yamasaki, Kazuyoshi Kawakami

JOURNAL OF IMMUNOLOGY　188　2012/05

ISSN： 0022-1767
東日本大震災後の避難所において発生したA型インフルエンザアウトブレイク事例 Peer-reviewed

遠藤史郎, 徳田浩一, 八田益充, 國島広之, 猪俣真也, 石橋令臣, 新井和明, 具芳明, 青柳哲史, 山田充啓, 矢野寿一, 北川美穂, 平潟洋一, 賀来満夫

日本環境感染学会誌　27　(1)　50-56　2012/01
Publisher:
DOI： 10.4058/jsei.27.50 　

ISSN： 1882-532X

eISSN： 1883-2407
Post-Tsunami Outbreaks of Influenza in Evacuation Centers in Miyagi Prefecture, Japan Peer-reviewed

Masumitsu Hatta, Shiro Endo, Koichi Tokuda, Hiroyuki Kunishima, Kazuaki Arai, Hisakazu Yano, Noriomi Ishibashi, Tetsuji Aoyagi, Mitsuhiro Yamada, Shinya Inomata, Hajime Kanamori, Yoshiaki Gu, Miho Kitagawa, Yoichi Hirakata, Mitsuo Kaku

CLINICAL INFECTIOUS DISEASES　54　(1)　E5-E7　2012/01

DOI： 10.1093/cid/cir752 　

ISSN： 1058-4838
High prevalence of extended-spectrum beta-lactamases and qnr determinants in Citrobacter species from Japan: dissemination of CTX-M-2 Peer-reviewed

Hajime Kanamori, Hisakazu Yano, Yoichi Hirakata, Shiro Endo, Kazuaki Arai, Miho Ogawa, Masahiro Shimojima, Tetsuji Aoyagi, Masumitsu Hatta, Mitsuhiro Yamada, Katsushi Nishimaki, Miho Kitagawa, Hiroyuki Kunishima, Mitsuo Kaku

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY　66　(10)　2255-2262　2011/10

DOI： 10.1093/jac/dkr283 　

ISSN： 0305-7453
The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury Peer-reviewed

Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Mei He, Takaya Suzuki, Naoya Fujino, Hiroyuki Kunishima, Masamitsu Hatta, Katsushi Nishimaki, Tetsuji Aoyagi, Kouichi Tokuda, Miho Kitagawa, Hisakazu Yano, Hirokazu Tamamura, Nobutaka Fujii, Mitsuo Kaku

CELLULAR & MOLECULAR IMMUNOLOGY　8　(4)　305-314　2011/07

DOI： 10.1038/cmi.2011.8 　

ISSN： 1672-7681
Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-gamma and TNF-alpha by Gr-1(+) monocytes International-journal Peer-reviewed

Aoyagi Tetsuji, Yamamoto Natsuo, Hatta Masumitsu, Tanno Daiki, Miyazato Akiko, Ishii Keiko, Suzuki Kazuo, Nakayama Toshinori, Taniguchi Masaru, Kunishima Hiroyuki, Hirakata Yoichi, Kaku Mitsuo, Kawakami Kazuyoshi

INTERNATIONAL IMMUNOLOGY　23　(2)　97-108　2011/02

DOI： 10.1093/intimm/dxq460 　

ISSN： 0953-8178
血流感染診断におけるプロカルシトニン定量測定の有用性

青柳哲史, 國島広之, 阿部裕子, 長沢光章, 石橋令臣, 金森肇, 遠藤史郎, 八田益充, 山田充浩, 西巻雄司, 高山陽子, 北川美穂, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

感染症学雑誌　85　(1)　102-103　2011/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
東北大学病院で検出された血液培養由来Candida属菌の検出状況と薬剤感受性の検討 Peer-reviewed

青柳哲史, 國島広之, 阿部裕子, 長沢光章, 石橋令臣, 金森肇, 遠藤史郎, 八田益充, 山田充啓, 西巻雄司, 徳田浩二, 北川美穂, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

日臨化東北会誌　20　12-18　2011
マウス肺炎球菌感染におけるTNF-α産生Gr-1陽性細胞の解析

丹野大樹, 八田益充, 青柳哲史, 山本夏男, 石井恵子, 賀来満夫, 川上和義

東北大学医学部保健学科紀要　19　(1)　13-21　2010
Publisher:
ISSN： 1348-8899
粘膜免疫粘膜免疫系に特徴的な細胞群とその機能リンパ節/脾臓と関連した肺における病原体特異的IL-13産生性T細胞とB-1B細胞の相互作用(Pathogen specific IL-13-producing T cells and B-1B cells interaction in lung associated lymph nodes and spleen)

Yamamoto Natsuo, Kerfoot Steven, Aoyagi Tetsuji, Delacruz Charles, Ishibashi Noriomi, Kunishima Hiroyuki, Takayama Yoko, Nishimaki Yuji, Yano Hisakazu, Hirakata Yoichi, Kawakami Kazuyoshi, Kaku Mitsuo, Askenase Philip

日本免疫学会総会・学術集会記録　39　40-40　2009/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
樹状細胞機能と分子基盤 Cryptococcus neoformans刺激によるデクチン-2依存性の骨髄樹状細胞活性化と宿主防御における役割(Dectin-2-dependent activation of myeloid dendritic cells stimulated with Cryptococcus neoformans and its role in the host defense)

Yamamoto Hideki, Yamamoto Natsuo, Tanaka Misuzu, Abe Yuzuru, Tanno Daiki, Aoyagi Tetsuji, Ishii Keiko, Saijo Shinobu, Iwakura Yoichiro, Kaku Mitsuo, Kawakami Kazuyoshi

日本免疫学会総会・学術集会記録　39　108-108　2009/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
内因性自然免疫炎症、修復反応全身性炎症反応症候群の新規マウスモデルの病理メカニズムに対するGr-1+細胞の関与(Contribution of Gr-1+ cells to The Pathogenic Mechanism in A NEW Mouse Model of Systemic Inflammatory Response Syndrome)

Tanno Daiki, Abe Yuzuru, Tanaka Misuzu, Ishii Keiko, Aoyagi Tetsuji, Yamamoto Natsuo, Kaku Mitsuo, Kawakami Kazuyoshi

日本免疫学会総会・学術集会記録　39　210-210　2009/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
急性細菌性肺炎におけるB-1B細胞機能のIL-13依存性の早期保護的役割(IL-13 Dependent Early Protective Role of B-1 B Cell Function in Acute Bacterial Pneumonia)

Yamamoto Natsuo, Kerfoot Steven M., Aoyagi Tetsuji, Hatta Masumitsu, Kunishima Hiroyuki, Miyazato Akiko, Hirakata Yoichi, Kawakami Kazuyoshi, Kaku Mitsuo, Askenase Philip W.

日本呼吸器学会雑誌　47　(増刊)　339-339　2009/05
Publisher: (一社)日本呼吸器学会
ISSN： 1343-3490
大学院学生における針刺し切創・体液曝露事例の現状

國島広之, 山本夏男, 天久康絢, 金森肇, 遠藤史郎, 青柳哲史, 位田剣, 北川美穂, 矢野寿一, 平潟洋一, 加來浩器, 賀来満夫

感染症学雑誌　83　(2)　194-195　2009/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
細菌感染と宿主応答細菌感染における病原体センサーと細菌由来因子による細胞機能の制御黄色ブドウ球菌外毒素であるLeukocidinによるTLR4を介した樹状細胞活性化の検討(TLR4-dependent dendritic cell activation by leukocidin, an exotoxin of Staphylococcus aureus)

位田剣, 宮里明子, 青柳哲史, 八田益充, 山本夏男, 賀来満夫, 川上和義

日本免疫学会総会・学術集会記録　38　152-152　2008/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
特殊なリンパ球 NKT細胞 a-GalCer-priming LPS誘導ALI/ARDSモデルにおけるサイトカインとGr-1陽性細胞の解析(Analysis of Gr-1+ cells and cytokines in an ALI/ARDS model mice caused by intratracheal a-GalCer-priming and LPS-challenge)

Aoyagi Tetsuji, Yamamoto Natsuo, Inden Ken, Hatta Masumitsu, Kaku Mitsuo, Kawakami Kazuyoshi

日本免疫学会総会・学術集会記録　38　78-78　2008/11
Publisher: (NPO)日本免疫学会
ISSN： 0919-1984
当院における抗酸菌の分離状況について

金森肇, 國島広之, 山本夏男, 天久康絢, 遠藤史郎, 青柳哲史, 位田剣, 八田益充, 平潟洋一, 加來浩器, 賀来満夫, 阿部裕子, 佐藤延子, 長沢光章

結核　83　(6)　481-482　2008/06
Publisher: (一社)日本結核・非結核性抗酸菌症学会
ISSN： 0022-9776

eISSN： 1884-2410
Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. International-journal Peer-reviewed

Kiwamu Nakamura, Akiko Miyazato, Gang Xiao, Masumitsu Hatta, Ken Inden, Tetsuji Aoyagi, Kohei Shiratori, Kiyoshi Takeda, Shizuo Akira, Shinobu Saijo, Yoichiro Iwakura, Yoshiyuki Adachi, Naohito Ohno, Kazuo Suzuki, Jiro Fujita, Mitsuo Kaku, Kazuyoshi Kawakami

Journal of immunology (Baltimore, Md. : 1950)　180　(6)　4067-74　2008/03/15

DOI： 10.4049/jimmunol.180.6.4067 　

ISSN： 0022-1767
黄色ブドウ球菌外毒素であるLeukocidinによる樹状細胞活性化の検討

位田剣, 宮里明子, 青柳哲史, 八田益充, 山本夏男, 賀来満夫, 川上和義

感染症学雑誌　82　(臨増)　303-303　2008/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
CD1d-dependent activation of NKT cells by Cryptococcus neoformans-pulsed dendritic cells Peer-reviewed

Tetsuji Aoyagi, Kiwamu Nakamura, Akiko Miyazato, Kiyotaka Nakagawa, Teruo Miyazawa, Yuki Kinjyo, Mitchell Kronenberg, Mitsuo Kaku, Kazuyoshi Kawakami

JOURNAL OF IMMUNOLOGY　178　2007/04

ISSN： 0022-1767

eISSN： 1550-6606
Protein C Deficiency in a Family with Thromboembolism and Identified Gene Mutations Peer-reviewed

Sakuo Hoshi, Minako Hijikata, Yuuki Togashi, Tetsuji Aoyagi, Chiyoko Kono, Yoshihito Yamada, Hiroko Amano, Naoto Keicho, Tetsuo Yamaguchi

INTERNAL MEDICINE　46　(13)　997-1003　2007

DOI： 10.2169/internalmedicine.46.6277 　

ISSN： 0918-2918
Correlation between disease stage and activity of elastase of PMN origin in the serum from IgA nephropachy patients. Peer-reviewed

Kojima M, Yamaguchi M, Kocha T, Fukuda T, Arimura Y, Nagasawa T, Suzuki K, Aoyagi T

J Clin Biochem Nutr　24　(3)　157-165　1998
Publisher: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
DOI： 10.3164/jcbn.24.157 　

ISSN： 0912-0009

More details Close

Activities of various enzymes including elastase were determined in sera from healthy control and from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgA nephropathy (IgA NP), and other renal failures. In IgA NP, the activity of elastase increased significantly in parallel with the disease stage. It correlated well with the increase in the amount of polymorphonuclear leukocyte-elastase (PMN-elastase)·α₁-antitrypsin complex assayed by ELISA, with the increase in myeloperoxidase (MPO) activity, and also with the increase in proteinuria. Studies on both substrate and inhibitor specificities of the elastase showed that the enzyme is indeed from PMN.

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Misc. 161

クリプトコックス潜在性感染マウスモデルにおけるFTY720投与による内因性再燃の免疫機序の解明

西田朱里, 佐藤光, 吉田美智子, 青柳哲史, 青柳哲史, 川上和義

日本医真菌学会雑誌　66　(Supplement 1)　2025

ISSN： 2434-5229
メロペネム出荷制限が当院に与えた影響

鈴木博也, 鈴木寿樹, 鈴木寿樹, 森下啓, 千葉僚, 金森肇, 金森肇, 佐藤哲哉, 徳田浩一, 青柳哲史, 青柳哲史

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　73rd-71st (CD-ROM)　2024
Analysis of the exacerbation of cryptococcal infection and the underlying immune mechanisms in diabetic mice

佐藤光, 神林直希, 丹野寛大, 菅野恵美, 青柳哲史, 青柳哲史, 石井恵子, 川上和義

日本生体防御学会学術総会講演抄録集　35th (Web)　2024
クリプトコックス潜在性感染マウスモデルを用いたFingolimod(FTY720)投与による内因性再燃の免疫機序の解明

吉田美智子, 中畑那奈, 篠宮岳志, 佐藤光, 菅野恵美, 丹野寛大, 石井恵子, 青柳哲史, 菊池敦生, 川上和義

日本小児感染症学会総会・学術集会プログラム・抄録集　55回　183-183　2023/11
Publisher: (一社)日本小児感染症学会
16Sr RNA遺伝子解析を用いた感染性腹部大動脈瘤17例の原因菌同定とHelicobacter cinaediに関する遺伝学的検討

角田梨紗子, 金森肇, 清水拓也, 猪股真也, 藤川祐子, 八田益充, 青柳哲史, 矢野寿一, 香取幸夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　72nd-70th　2023
宮城県における侵襲性リステリア症の分子疫学的検討

馬場啓聡, 金森肇, 角田梨紗子, 桜井博毅, 大島謙吾, 青柳哲史, 賀来満夫

日本臨床腸内微生物学会誌　23　(1)　61-66　2021/06
Publisher: 日本臨床腸内微生物学会

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2006〜2019年の宮城県内の三次医療施設4施設における侵襲性リステリア症症例について後ろ向きに調査した。網羅的病原遺伝子解析の結果、検出された全18株のListeria monocytogenes中、血清型IVbが10株(55%)と最も多く、その内訳はIVb-CC6型が4株(22%)、IVb-CC1およびIVb-CC2がそれぞれ3株(17%)であった。病原遺伝子の分布はそれぞれの遺伝子型毎に特徴を認めたが、遺伝子型と疾患とに関係性は見られなかった。分子系統解析では、2007年に菌血症患者から検出された株と、2012年に感染性大動脈瘤(IAA)患者から検出された株、および2015年にIAA患者から検出された株と2017年に髄膜炎患者から検出された株はそれぞれ同じCT型(IVb-CT1およびIVb-CT6)に属し、それぞれ異なる遺伝子が10個以下と相同性が非常に高かった。NCBIデータベース上の株と、宮城県で得られた株計277株の中で、遺伝子型IVb-CC1・2・6型と、それ以外の遺伝子型の株との病原遺伝子の分布を比較した。その結果、IVb-CC1・2・6型株は細胞壁に存在し宿主細胞への接着に関与するタイコ酸合成遺伝子gltA・gltBおよびLIPI-3遺伝子や、宿主細胞への侵入に関わるaut_IVbやvipの各病原遺伝子を他の遺伝子型株に比べ有意に多く保有していた。分子系統解析では、2013年宮城県・胎内感染症例由来株と2003年ブラジル・ポークソーセージ由来株、1931年アメリカ合衆国・由来不明株と1961年イギリス・鶏由来株、アメリカ合衆国・採取年・由来不明株と2005年ロシア・Myodes rufocanus由来株の遺伝的相同性がそれぞれ非常に高かった。
Usefulness of Rapid Diagnostic Tests for Infectious Diseases in Natural Disaster: Clinical Aspects and Management for Infection Prevention and Control

Tetsuji AOYAGI

Japanese Journal of Infection Prevention and Control　36　(3)　127-135　2021/05/25
Publisher: Japanese Society of Environmental Infections
DOI： 10.4058/jsei.36.127 　

ISSN： 1882-532X

eISSN： 1883-2407
職業感染制御委員会・臨床研究推進委員会新型コロナウイルス感染症診療における医療従事者の針刺し切創についてのアンケート調査

國島広之, 吉川徹, 網中眞由美, 遠藤史郎, 菅野みゆき, 豊川真弘, 貫井陽子, 藤田昌久, 森兼啓太, 四柳宏, 和田耕治, 佐藤智明, 青柳哲史, 飯沼由嗣, 泉川公一, 植田貴史, 内山正子, 藤村茂, 美島路恵, 三鴨廣繁, 職業感染制御委員会

日本環境感染学会誌　36　(3)　179-180　2021/05
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X

eISSN： 1883-2407
職業感染制御委員会・臨床研究推進委員会医療従事者の新型コロナウイルス感染症感染事例についてのアンケート調査

國島広之, 吉川徹, 網中眞由美, 遠藤史郎, 菅野みゆき, 豊川真弘, 貫井陽子, 藤田昌久, 森兼啓太, 四柳宏, 和田耕治, 佐藤智明, 青柳哲史, 飯沼由嗣, 泉川公一, 植田貴史, 内山正子, 藤村茂, 美島路恵, 三鴨廣繁, 職業感染制御委員会

日本環境感染学会誌　36　(3)　181-183　2021/05
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X

eISSN： 1883-2407
職業感染制御委員会・臨床研究推進委員会新型コロナウイルス感染症診療における医療従事者の針刺し切創についてのアンケート調査

國島広之, 吉川徹, 網中眞由美, 遠藤史郎, 菅野みゆき, 豊川真弘, 貫井陽子, 藤田昌久, 森兼啓太, 四柳宏, 和田耕治, 佐藤智明, 青柳哲史, 飯沼由嗣, 泉川公一, 植田貴史, 内山正子, 藤村茂, 美島路恵, 三鴨廣繁, 職業感染制御委員会

日本環境感染学会誌　36　(3)　179-180　2021/05
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X

eISSN： 1883-2407
職業感染制御委員会・臨床研究推進委員会医療従事者の新型コロナウイルス感染症感染事例についてのアンケート調査

國島広之, 吉川徹, 網中眞由美, 遠藤史郎, 菅野みゆき, 豊川真弘, 貫井陽子, 藤田昌久, 森兼啓太, 四柳宏, 和田耕治, 佐藤智明, 青柳哲史, 飯沼由嗣, 泉川公一, 植田貴史, 内山正子, 藤村茂, 美島路恵, 三鴨廣繁, 職業感染制御委員会

日本環境感染学会誌　36　(3)　181-183　2021/05
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X

eISSN： 1883-2407
【Special feature 診療危機に立ち向かう新型コロナ対策マネジメント】Pros & Cons 新型コロナ患者の受け入れ時マネジメント-最新知見と現場の実情コロナ(疑い)患者の検査マネジメント検査回数と組み合わせ,呼吸器系検査の要否の考え方

青柳哲史

感染対策ICTジャーナル　16　(2)　106-110　2021/04
Publisher: (株)ヴァンメディカル
ISSN： 1881-4964
担癌患者および自己免疫疾患患者における緑膿菌による前立腺膿瘍の2例

清家一生, 金森肇, 武井健太郎, 新妻郁未, 馬場啓聡, 大島謙吾, 徳田浩一, 青柳哲史

感染症学雑誌　95　(臨増)　217-217　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Rhodotorula mucilaginosaによるカテーテル関連血流感染症の1例

佐藤裕真, 金森肇, 清家一生, 新妻郁未, 武井健太郎, 馬場啓聡, 大島謙吾, 徳田浩一, 青柳哲史

感染症学雑誌　95　(臨増)　218-218　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Good症候群に伴うサイトメガロウイルス網膜炎の一例

武井健太郎, 金森肇, 清家一生, 新妻郁未, 馬場啓聡, 大島謙吾, 徳田浩一, 青柳哲史

感染症学雑誌　95　(臨増)　225-225　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
発熱と皮疹を主訴としたCOVID-19の2例

清家一生, 金森肇, 馬場啓聡, 新妻郁未, 武井健太郎, 大島謙吾, 徳田浩一, 青柳哲史

感染症学雑誌　95　(臨増)　259-259　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
エクリズマブ投与患者における播種性淋菌感染症の1例

新妻郁未, 金森肇, 清家一生, 武井健太郎, 馬場啓聡, 大島謙吾, 青柳哲史, 徳田浩一

感染症学雑誌　95　(臨増)　289-289　2021/04
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
新規超高速PCR機器GeneSoCの鼻腔MRSA検出性能の評価

千葉美紀子, 青柳哲史, 中山麻美, 勝見真琴, 藤巻慎一, 藤原亨, 吉田眞紀子, 賀来満夫

医療検査と自動化(Web)　46　(4)　2021

ISSN： 2435-2713
Simultaneous analysis of remdesivir, favipiravir, and etoposide used to treat COVID-19 infection using liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring

高崎新也, 佐藤稔之, 鈴木博也, 青柳哲史, 青柳哲史, 森下啓, 千葉僚, 佐藤裕, 佐藤紀宏, 菊地正史, 大島謙吾, 徳田浩一, 前川正充, 眞野成康

JSBMS Letters　46　(Supplement)　117-117　2021
Publisher: (一社)日本医用マススペクトル学会
ISSN： 1881-5464
担癌患者および自己免疫疾患患者における緑膿菌による前立腺膿瘍の2例

清家一生, 金森肇, 金森肇, 金森肇, 武井健太郎, 新妻郁未, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史

日本化学療法学会雑誌　69　(Supplement-A)　2021

ISSN： 1340-7007
Good症候群に伴うサイトメガロウイルス網膜炎の一例

武井健太郎, 金森肇, 金森肇, 金森肇, 清家一生, 新妻郁未, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史, 青柳哲史

日本化学療法学会雑誌　69　(Supplement-A)　2021

ISSN： 1340-7007
発熱と皮疹を主訴としたCOVID-19の2例

清家一生, 金森肇, 金森肇, 金森肇, 馬場啓聡, 馬場啓聡, 新妻郁未, 武井健太郎, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史

日本化学療法学会雑誌　69　(Supplement-A)　2021

ISSN： 1340-7007
Rhodotorula mucilaginosaによるカテーテル関連血流感染症の1例

佐藤裕真, 佐藤裕真, 金森肇, 清家一生, 新妻郁未, 武井健太郎, 馬場啓聡, 大島謙吾, 徳田浩一, 青柳哲史

日本化学療法学会雑誌　69　(Supplement-A)　2021

ISSN： 1340-7007
エクリズマブ投与患者における播種性淋菌感染症の1例

新妻郁未, 金森肇, 金森肇, 金森肇, 清家一生, 武井健太郎, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 徳田浩一, 徳田浩一, 徳田浩一

日本化学療法学会雑誌　69　(Supplement-A)　2021

ISSN： 1340-7007
COVID-19 Among Healthcare Workers: A Questionnaire Survey

國島広之, 國島広之, 吉川徹, 網中眞由美, 遠藤史郎, 菅野みゆき, 豊川真弘, 貫井陽子, 藤田昌久, 森兼啓太, 四柳宏, 和田耕治, 佐藤智明, 青柳哲史, 飯沼由嗣, 泉川公一, 植田貴史, 内山正子, 藤村茂, 美島路恵, 三鴨廣繁

日本環境感染学会誌(Web)　36　(3)　2021

ISSN： 1883-2407
【新型コロナウイルス禍に学ぶ地域感染対策ネットワーク】東北感染症危機管理ネットワークの取り組みと新型コロナウイルス感染症への対応

吉田眞紀子, 青柳哲史, 賀来満夫

地域連携入退院と在宅支援　13　(5)　2-8　2020/11
Publisher: 日総研出版
単球/マクロファージ制御による致死性急性呼吸窮迫症候群(ARDS)の治療

青柳哲史, 佐藤由紀夫, 川上和義, 賀来満夫

日本化学療法学会雑誌　68　(5)　563-575　2020/09
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
敗血症患者における微生物遺伝子検査は本当に臨床的に有用? Consの立場から

青柳哲史

日本化学療法学会雑誌　68　(Suppl.A)　257-257　2020/09
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
東南アジアで獲得したメタロβ-ラクタマーゼ産生多剤耐性緑膿菌による髄膜炎の1例

馬場啓聡, 金森肇, 鈴木由希, 中野竜一, 大江千紘, 大島謙吾, 青柳哲史, 徳田浩一, 矢野寿一, 賀来満夫

感染症学雑誌　94　(2)　255-255　2020/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
敗血症における細胞外小胞体に包埋されるIL-36サイトカインの基礎的検討

青柳哲史, 馬場啓聡, 金森肇, 大島謙吾, 吉田眞紀子, 徳田浩一, 賀来満夫

感染症学雑誌　94　(2)　272-273　2020/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
グラム陰性桿菌血液培養陽性例における好気・嫌気ボトル検出パターンに関する検討

平田和成, 金森肇, 馬場啓聡, 勝見真琴, 大島謙吾, 青柳哲史, 徳田浩一

感染症学雑誌　94　(2)　275-275　2020/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
感染症Emergency-症例報告を通して- 救急医と感染症医とのコラボレーションともに診療した難治性緑膿菌感染症

工藤大介, 青柳哲史

感染症学雑誌　94　(臨増)　234-234　2020/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
感染症におけるMolecular Diagnostics 進化と挑戦

青柳哲史

感染症学雑誌　94　(臨増)　360-360　2020/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
感染管理と迅速検査災害時でも活用できる迅速検査災害時など環境・物的資源が限られているときでも活用できる迅速検査

青柳哲史

日本環境感染学会総会プログラム・抄録集　35回　SY5-4　2020/02
Publisher: (一社)日本環境感染学会
感染症に関する話題今そこにある危機

青柳哲史

宮城県医師会報　(887)　920-925　2019/12
Publisher: (公社)宮城県医師会
【高齢者の呼吸器感染症治療-症例が示すマネジメントの最前線】肺炎肺炎球菌

青柳哲史

感染と抗菌薬　22　(4)　223-228　2019/12
Publisher: (株)ヴァンメディカル
ISSN： 1344-0969
2014年臨床分離好気性グラム陽性菌および嫌気性菌の薬剤感受性サーベイランス

阿南直美, 山城秀仁, 高橋俊司, 菅野のぞみ, 賀来満夫, 青柳哲史, 森兼啓太, 中島啓喜, 小野由可, 長田ゆかり, 松尾収二, 西功, 草野展周, 能勢資子, 田仲祐子, 野上智, 宮本仁志, 村上忍, 平松和史, 三浦慎和, 森永芳智, 柳原克紀, 上地幸平, 前田士郎, 吉田立

The Japanese Journal of Antibiotics　72　(4)　271-300　2019/12
Publisher: (公財)日本感染症医薬品協会
ISSN： 0368-2781

eISSN： 2186-5477
血液培養からMycobacterium brisbanenseを検出した一症例

石戸谷真帆, 佐藤敦子, 三浦悠理子, 佐藤亜耶, 佐藤貴美, 千葉美紀子, 羽島房子, 庄司淳子, 勝見真琴, 阿部裕子, 藤巻慎一, 青柳哲史

日本臨床微生物学会雑誌　30　(Suppl.1)　255-255　2019/12
Publisher: (一社)日本臨床微生物学会
ISSN： 2434-866X
【患者のQにきっぱり答えるおとなの予防接種】ワクチン別患者のQの答え方肺炎球菌ワクチン

青柳哲史

調剤と情報　25　(15)　2405-2409　2019/11
Publisher: (株)じほう
ISSN： 1341-5212
2014年臨床分離好気性グラム陰性菌の薬剤感受性サーベイランス

阿南直美, 山城秀仁, 高橋俊司, 菅野のぞみ, 賀来満夫, 青柳哲史, 森兼啓太, 中島啓喜, 小野由可, 長田ゆかり, 松尾収二, 西功, 草野展周, 能勢資子, 田仲祐子, 野上智, 宮本仁志, 村上忍, 平松和史, 三浦慎和, 森永芳智, 柳原克紀, 上地幸平, 前田士郎, 吉田立

The Japanese Journal of Antibiotics　72　(3)　219-244　2019/09
Publisher: (公財)日本感染症医薬品協会
ISSN： 0368-2781

eISSN： 2186-5477
高齢者の肺炎予防に対してワクチン接種以外で注目されている予防方法は? プロバイオティクスによる予防効果が得られる人がいる可能性はあるが、その特定が課題

森永芳智, 青柳哲史

日本医事新報　(4963)　51-52　2019/06
Publisher: (株)日本医事新報社
ISSN： 0385-9215
肺炎球菌ワクチンの効果はどの程度、期待できるのでしょうか? PPSV23の予防効果は一般的に5年と考えられている

青柳哲史, 國島広之

日本医事新報　(4960)　44-45　2019/05
Publisher: (株)日本医事新報社
ISSN： 0385-9215
免疫学から切り込んだ感染症学炎症性単球/マクロファージに着目した呼吸器感染症増悪メカニズムと治療戦略

青柳哲史, 佐藤由紀夫, 賀来満夫

感染症学雑誌　93　(臨増)　262-262　2019/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
志賀毒素産生性大腸菌臨床分離株の分子疫学的特徴

馬場啓聡, 金森肇, 岡健太郎, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

感染症学雑誌　93　(臨増)　367-367　2019/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
志賀毒素産生性大腸菌臨床分離株の分子疫学的特徴

馬場啓聡, 金森肇, 岡健太郎, 岡健太郎, 高橋志達, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

感染症学雑誌　93　(臨増)　367-367　2019/03/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Candida菌血症の予後改善のためのCandida Care Bundle評価

新妻郁未, 青柳哲史, 馬場啓聡, 金森肇, 大島謙吾, 吉田眞紀子, 徳田浩一, 賀来満夫

日本化学療法学会雑誌　67　(Suppl.A)　256-256　2019/03
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
Candida菌血症の予後改善のためのCandida Care Bundle評価

新妻郁未, 青柳哲史, 馬場啓聡, 金森肇, 大島謙吾, 吉田眞紀子, 徳田浩一, 賀来満夫

日本化学療法学会雑誌　67　(Suppl.A)　256-256　2019/03
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
東南アジアで獲得したメタロβ-ラクタマーゼ産生多剤耐性緑膿菌による髄膜炎の一例

馬場啓聡, 馬場啓聡, 金森肇, 金森肇, 鈴木由希, 中野竜一, 大江千紘, 大江千紘, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 徳田浩一, 徳田浩一, 矢野寿一, 賀来満夫, 賀来満夫, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　68th-66th　2019
黄色ブドウ球菌におけるqacA/Bやsmr遺伝子の保有頻度および抗菌薬耐性の検討

河村真人, 遠藤史郎, 徳田浩一, 青柳哲史, 賀来満夫, 渡辺彰, 藤村茂

日本化学療法学会雑誌　67　(1)　125-126　2019/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
ディスク法によるSerratia marcescensのESBL産生性の評価

馬場啓聡, 金森肇, 遠藤史郎, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 矢野寿一, 賀来満夫

感染症学雑誌　93　(1)　74-74　2019/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

馬場啓聡, 金森肇, 工藤逸美, 岡健太郎, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

日本臨床腸内微生物学会誌　21　(1)　56-56　2019
Publisher: 日本臨床腸内微生物学会
急性期病院で分離されたカルバペネム耐性腸内細菌科細菌(CRE)の解析

牧野祐子, 金森肇, 遠藤史郎, 馬場啓聡, 大江千紘, 吉田眞紀子, 大島謙吾, 青柳哲史, 徳田浩一, 児玉栄一, 矢野寿一, 賀来満夫

感染症学雑誌　93　(1)　74-75　2019/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Outbreak Databaseを活用した外来におけるアウトブレイクの特徴の把握

牧野祐子, 金森肇, 徳田浩一, 大江千紘, 馬場啓聡, 吉田眞紀子, 大島謙吾, 青柳哲史, 賀来満夫

感染症学雑誌　93　(1)　95-95　2019/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Outbreak Databaseを活用した高齢者施設におけるアウトブレイクの疫学的特徴と傾向

牧野祐子, 金森肇, 徳田浩一, 大江千紘, 馬場啓聡, 吉田眞紀子, 大島謙吾, 青柳哲史, 賀来満夫

感染症学雑誌　93　(1)　95-95　2019/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
O157以外の志賀毒素産生性大腸菌(non-O157 STEC)臨床分離株の分子疫学的解析

馬場啓聡, 金森肇, 岡健太郎, 高橋志逹, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫, 工藤逸美, 黒木靖敏, 東聖也

感染症学雑誌　93　(1)　99-99　2019/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911

eISSN： 1884-569X
Desulfovibrio desulfuricansによる細菌性胸膜炎および敗血症の一例

勝見真琴, 三浦悠理子, 平田和成, 佐藤貴美, 千葉美紀子, 石戸谷真帆, 羽島房子, 庄司淳子, 舛甚満, 阿部裕子, 藤巻慎一, 青柳哲史, 賀来満夫

日本臨床微生物学会雑誌　29　(Suppl.1)　446-446　2018/12
Publisher: (一社)日本臨床微生物学会
ISSN： 2434-866X
Outbreak Databaseを活用した高齢者施設におけるアウトブレイクの疫学的特徴と傾向

牧野祐子, 牧野祐子, 金森肇, 金森肇, 徳田浩一, 徳田浩一, 大江千紘, 大江千紘, 馬場啓聡, 馬場啓聡, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　157　2018/10
Outbreak Databaseを活用した外来におけるアウトブレイクの特徴の把握

牧野祐子, 牧野祐子, 金森肇, 金森肇, 徳田浩一, 徳田浩一, 大江千紘, 大江千紘, 馬場啓聡, 馬場啓聡, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　157　2018/10
ディスク法によるSerratia marcescensのESBL産生性の評価

馬場啓聡, 金森肇, 遠藤史郎, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 矢野寿一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　135　2018/10
急性期病院で分離されたカルバペネム耐性腸内細菌科細菌(CRE)の解析

牧野祐子, 金森肇, 遠藤史郎, 馬場啓聡, 大江千紘, 吉田眞紀子, 大島謙吾, 青柳哲史, 徳田浩一, 児玉栄一, 矢野寿一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　136　2018/10
Listeria monocytogenes感染症12例の臨床的検討

馬場啓聡, 金森肇, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　173　2018/10
O157以外の志賀毒素産生性大腸菌(non‐O157 STEC)臨床分離株の分子疫学的解析

馬場啓聡, 金森肇, 岡健太郎, 高橋志逹, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　164　2018/10
介護老人施設における腸内細菌叢と抗菌薬耐性遺伝子の保有率に関する検討

山崎行敬, 國島広之, 廣瀬雅宣, 和田薫子, 青柳哲史, 遠藤史郎, 岡健太郎, 高橋志達, 賀来満夫

日本臨床腸内微生物学会誌　20　(1)　117-117　2018/08
Publisher: 日本臨床腸内微生物学会
宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

馬場啓聡, 金森肇, 工藤逸美, 岡健太郎, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　21回　28-28　2018/08
Publisher: 日本臨床腸内微生物学会
宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

馬場啓聡, 金森肇, 工藤逸美, 岡健太郎, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　21回　28-28　2018/08
Publisher: 日本臨床腸内微生物学会
クロルヘキシジングルコン酸塩に抵抗性を獲得したP.aeruginosaにおける抗菌薬交叉耐性

河村真人, 藤村茂, 遠藤史郎, 徳田浩一, 青柳哲史, 古川恵美子, 渡辺彰, 賀来満夫, 鎌田勇也

日本化学療法学会雑誌　66　(3)　463-463　2018/05
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
SDSEによる腹部大動脈人工血管感染症の1例

角田梨紗子, 遠藤史郎, 矢野寿一, 清水拓也, 具芳明, 青柳哲史, 八田益充, 金森肇, 徳田浩一, 賀来満夫, 後藤均

感染症学雑誌　92　(3)　468-468　2018/05
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
日本の医療関連アウトブレイクの疫学的特徴

金森肇, 金森肇, 徳田浩一, 徳田浩一, 牧野祐子, 大江千紘, 馬場啓聡, 藤川祐子, 北川美穂, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

日本化学療法学会雑誌　66　(Supplement-A)　362-362　2018/04/25
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
宮城県の市中におけるCTX‐M‐27型ESBL産生大腸菌ST131の拡散

藤川祐子, 遠藤史郎, 矢野寿一, 金森肇, 大島謙吾, 青柳哲史, 徳田浩一, 吉田眞紀子, 賀来満夫

日本化学療法学会雑誌　66　(Supplement-A)　250-250　2018/04/25
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
クロルヘキシジングルコン酸塩のMSW生残P.aeruginosa株における抗菌薬交叉耐性とEfflux pumpの働き

河村真人, 藤村茂, 遠藤史郎, 徳田浩一, 青柳哲史, 渡辺彰, 賀来満夫

日本化学療法学会雑誌　66　(Suppl.A)　253-253　2018/04
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
SDSEによる腹部大動脈人工血管感染症の一例

角田梨紗子, 角田梨紗子, 遠藤史郎, 遠藤史郎, 矢野寿一, 矢野寿一, 清水拓也, 具芳明, 具芳明, 青柳哲史, 八田益充, 金森肇, 徳田浩一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　66th-64th　161　2017/09
成人の侵襲性肺炎球菌感染症(IPD)の臨床像と原因菌血清型分布に関する疫学(2013年-2014年)

福住宗久, 西順一郎, 丸山貴也, 渡邊浩, 大島謙吾, 青柳哲史, 高橋弘毅, 武田博明, 田邊嘉也, 笠原敬, 藤田次郎, 横山彰仁, 山崎一美, 常彬, 大西真, 高橋琢理, 松井珠乃, 砂川富正, 大石和徳

日本化学療法学会雑誌　64　(3)　590-590　2016/05
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007
宮城県における成人侵襲性肺炎球菌感染症の由来菌株の血清型分布についての検討

大島謙吾, 青柳哲史, 鈴木由希, 馬場啓聡, 斎藤恭一, 藤川祐子, 曽木美佐, 具芳明, 遠藤史郎, 大石和徳, 賀来満夫

日本化学療法学会雑誌　64　(Suppl.A)　203-203　2016/05
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
カルバペネム耐性肺炎桿菌および基質特異性拡張型β-ラクタマーゼ産生大腸菌のラクタマーゼ産生と耐性伝達に対するプロバイオティクスおよび腸内細菌の影響

國島広之, 石橋令臣, 和田薫子, 廣瀬雅宣, 大島謙吾, 青柳哲史, 遠藤史郎, 岡健太郎, 高橋志達, 松田隆秀, 賀来満夫

日本臨床腸内微生物学会誌　18　(1)　80-83　2016/05
Publisher: 日本臨床腸内微生物学会
東北大学病院におけるCandida guilliermondii血症の現状

藤川祐子, 青柳哲史, 大島謙吾, 具芳明, 八田益充, 遠藤史郎, 中島一敏, 賀来満夫

感染症学雑誌　89　(臨増)　278-278　2015/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
16S rRNAシークエンスが有用であった感染性腹部大動脈瘤破裂の1例

齋藤恭一, 角田梨紗子, 大島謙吾, 青柳哲史, 八田益充, 具芳明, 遠藤史郎, 中島一敏, 矢野寿一, 賀来満夫

感染症学雑誌　89　(2)　337-337　2015/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
血液培養由来Bacillus cereusの病原性・遺伝子学的評価

河内美奈, 青柳哲史, 大島謙吾, 遠藤史郎, 八田益充, 具芳明, 中島一敏, 賀来満夫

感染症学雑誌　89　(2)　350-351　2015/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
DiagnoSepが敗血症の原因菌推定に有用であった一症例

小澤大樹, 矢野寿一, 遠藤史郎, 猪股真也, 中島一敏, 八田益充, 青柳哲史, 具芳明, 大島謙吾, 賀来満夫

日本臨床微生物学雑誌　25　(Suppl.1)　216-216　2014/12
Publisher: (一社)日本臨床微生物学会
ISSN： 0917-5059

eISSN： 1880-6309
宮城県の耳鼻咽喉科から分離された肺炎球菌における薬剤感受性の解析 2001年から2012年までの12年間の推移

小澤大樹, 矢野寿一, 角田梨紗子, 猪股真也, 金森肇, 遠藤史郎, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫

感染症学雑誌　88　(5)　726-726　2014/09
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
炎症性単球をターゲットにした劇症型急性肺傷害実験動物モデルの治療

青柳哲史, 佐藤由紀夫, 川上和義, 河内美奈, 金森肇, 遠藤史郎, 八田益充, 具芳明, 徳田浩一, 矢野寿一, 賀来満夫, 外山真彦

感染症学雑誌　88　(5)　728-728　2014/09
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
ヒトおよび環境中から検出されたBacillus cereusの病原性・遺伝子学的評価

河内美奈, 青柳哲史, 岸原康浩, 徳田浩一, 小林良三, 田中沙希恵, 金森肇, 遠藤史郎, 八田益充, 具芳明, 矢野寿一, 賀来満夫, 伊藤有紀, 小川美保

感染症学雑誌　88　(5)　743-743　2014/09
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
本邦で分離された小児急性中耳炎中耳貯留液由来インフルエンザ菌の薬剤感受性とアンピシリン耐性株の分子疫学的解析

角田梨紗子, 矢野寿一, 小澤大樹, 金森肇, 遠藤史郎, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫

感染症学雑誌　88　(5)　774-775　2014/09
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
宮城県の耳鼻咽喉科から分離された肺炎球菌における薬剤感受性の解析:2001年から2012年までの12年間の推移

小澤大樹, 矢野寿一, 角田梨紗子, 猪股真也, 金森肇, 遠藤史郎, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫

日本化学療法学会総会プログラム・講演抄録　62nd　(Suppl.A)　217-217　2014/05/19
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
炎症性単球をターゲットにした劇症型急性肺傷害実験動物モデルの治療

青柳哲史, 佐藤由紀夫, 川上和義, 河内美奈, 金森肇, 遠藤史郎, 八田益充, 具芳明, 徳田浩一, 矢野寿一, 賀来満夫

日本化学療法学会雑誌　62　(Suppl.A)　220-220　2014/05/19
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
ヒトおよび環境中から検出されたBacillus cereusの病原性・遺伝子学的評価

河内美奈, 青柳哲史, 岸原康浩, 徳田浩一, 小林良三, 田中沙希恵, 金森肇, 遠藤史郎, 八田益充, 具芳明, 矢野寿一, 賀来満夫

日本化学療法学会雑誌　62　(Suppl.A)　240-240　2014/05/19
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
本邦で分離された小児急性中耳炎中耳貯留液由来インフルエンザ菌の薬剤感受性とアンピシリン耐性株の分子疫学的解析

角田梨紗子, 矢野寿一, 小澤大樹, 金森肇, 遠藤史郎, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫

日本化学療法学会雑誌　62　(Suppl.A)　272-272　2014/05/19
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
仙台市青葉区および宮城県大崎市における外来抗菌薬使用量調査

具芳明, 矢野寿一, 徳田浩一, 八田益充, 青柳哲史, 遠藤史郎, 金森肇, 賀来満夫

日本化学療法学会雑誌　62　(Suppl.A)　412-412　2014/05/19
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
Helicobacter cinaediが原因菌と考えられた感染性腹部大動脈瘤の1例

角田梨紗子, 矢野寿一, 具芳明, 八田益充, 青柳哲史, 遠藤史郎, 大江千紘, 猪股真也, 小澤大樹, 徳田浩一, 賀来満夫

感染症学雑誌　88　(2)　230-231　2014/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
重度な免疫不全のない患者に発症した耳鼻科領域侵襲性糸状菌感染症の3例

大江千紘, 青柳哲史, 具芳明, 八田益充, 角田梨紗子, 小澤大樹, 遠藤史郎, 矢野寿一, 徳田浩一, 賀来満夫

感染症学雑誌　88　(2)　248-248　2014/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
インターネット販売での抗菌薬購入経験とニーズについてのインターネット調査

具芳明, 吉田眞紀子, 矢野寿一, 徳田浩一, 八田益充, 青柳哲史, 遠藤史郎, 大江千紘, 賀来満夫

感染症学雑誌　88　(2)　258-259　2014/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
東北大学病院におけるClostridium difficile関連下痢症の現状

石澤千幸, 遠藤史郎, 徳田浩一, 金森肇, 大江千紘, 猪股真也, 青柳哲史, 八田益充, 具芳明, 矢野寿一, 長沢光章, 賀来満夫

感染症学雑誌　88　(2)　237-238　2014/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
硬膜外膿瘍を伴った化膿性脊椎炎より分離されたParuvimonas micra

遠藤史郎, 矢野寿一, 角田梨紗子, 勝美真琴, 小澤大樹, 大江千紘, 猪股真也, 金森肇, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫, 根本忠信

感染症学雑誌　88　(2)　252-252　2014/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Improvement In Lipopolysaccharide-Induced Fulminate Acute Respiratory Distress Syndrome Model By Etoposide Plus Steroid Therapy

T. Aoyagi, Y. Sato, K. Kawakami, M. Toyama, K. Ishi, H. Kanamori, S. Endo, M. Hatta, Y. Gu, K. Tokuda, H. Yano, M. Kaku

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　189　2014

ISSN： 1073-449X

eISSN： 1535-4970
硬膜外膿瘍を伴った化膿性脊椎炎より分離されたParuvimonas micra

遠藤史郎, 矢野寿一, 角田梨紗子, 勝美真琴, 小澤大樹, 大江千紘, 猪股真也, 金森肇, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　62nd-60th　143　2013/10
東北大学病院におけるClostridium difficile関連下痢症の現状

石澤千幸, 遠藤史郎, 徳田浩一, 金森肇, 大江千紘, 猪股真也, 青柳哲史, 八田益充, 具芳明, 矢野寿一, 長沢光章, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　62nd-60th　127　2013/10
Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome

D. Kudo, D. Kudo, M. Toyama, T. Aoyagi, Y. Akahori, H. Yamamoto, K. Ishii, E. Kanno, R. Maruyama, M. Kaku, S. Kushimoto, K. Kawakami

Clinical and Experimental Immunology　173　276-287　2013/08/01

DOI： 10.1111/cei.12106 　

ISSN： 0009-9104
東北大学病院における血液培養から分離されたAcinetobacter属の分子疫学的解析

遠藤史郎, 矢野寿一, 金森肇, 猪股真也, 石橋令臣, 青柳哲史, 八田益充, 具芳明, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

感染症学雑誌　87　(臨増)　196-196　2013/05/07
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
肺線維化をきたすインフルエンザウイルス感染肺傷害モデルマウスの作成

青柳哲史, 川上和義, 石井恵子, 金森肇, 遠藤史郎, 八田益充, 具芳明, 徳田浩一, 矢野寿一, 國島広之, 北川美穂, 賀来満夫

感染症学雑誌　87　(臨増)　231-231　2013/05/07
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
肺線維化を来たすインフルエンザウイルス誘発急性肺傷害モデルマウスの作成

青柳哲史, 川上和義, 石井恵子, 山田充啓, 金森肇, 國島広之, 賀来満夫

日本呼吸器学会誌　2　(増刊)　147-147　2013/03/10
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
Lung Fibrosis After Acute Lung Injury Caused By H1n1 Influenza Virus Infection In Mice

T. Aoyagi, K. Kawakami, K. Ishii, M. Yamada, H. Kunishima, M. Kaku

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　187　2013

ISSN： 1073-449X

eISSN： 1535-4970
ARDSにおけるHMGB1の関与とトロンボモジュリンによる抑制効果

外山真彦, 工藤大介, 青柳哲史, 石井恵子, 久志本成樹, 賀来満夫, 川上和義

日本生体防御学会学術総会講演抄録集　24th　33　2013
新型インフルエンザ等の院内感染制御に関する研究新型インフルエンザ等の院内感染制御に関する研究

賀来満夫, 國島広之, 北川美穂, 青柳哲史, 八田益充, 徳田浩一, 金森肇

新型インフルエンザ等の院内感染制御に関する研究平成24年度総括・分担研究報告書　53-66　2013
本邦で分離されたメタロ-β-ラクタマーゼ産生大腸菌についての検討

矢野寿一, 小川美保, 遠藤史郎, 金森肇, 角田梨紗子, 猪股真也, 霜島正浩, 石橋令臣, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 國島広之, 北川美穂, 平潟洋一, 賀来満夫

日本化学療法学会雑誌　61　(1)　44-44　2013/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
血液培養から分離されたカルバペネム耐性Acinetobacter ursingiiの耐性遺伝子の解析

遠藤史郎, 笹野美奈, 矢野寿一, 猪股真也, 石橋令臣, 金森肇, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

日本化学療法学会雑誌　61　(1)　106-106　2013/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
東日本大震災の影響を含めた宮城県の薬剤耐性菌の動向調査

石橋令臣, 國島広之, 小松真由美, 猪股真也, 金森肇, 遠藤史郎, 具芳明, 青柳哲史, 八田益充, 山田充啓, 徳田浩一, 矢野寿一, 北川美穂, 賀来満夫

日本化学療法学会雑誌　61　(1)　110-110　2013/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
結核性胸膜炎の治療中に発症した胸囲結核の1例

金森肇, 猪股真也, 石橋令臣, 遠藤史郎, 青柳哲史, 八田益充, 徳田浩一, 矢野寿一, 北川美穂, 賀来満夫, 具芳明, 山田充啓, 國島広之, 内山美寧, 平潟洋一, 磯上勝彦

結核　87　(12)　822-823　2012/12/15
Publisher: (一社)日本結核病学会
ISSN： 0022-9776

eISSN： 1884-2410
血液培養から分離されたカルバペネム耐性Acinetobacter ursingiiの耐性遺伝子の解析

遠藤史郎, 笹野美奈, 矢野寿一, 猪股真也, 石橋令臣, 金森肇, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　61st-59th　289　2012/09
東日本大震災の影響を含めた宮城県の薬剤耐性菌の動向調査

石橋令臣, 國島広之, 小松真由美, 猪股真也, 金森肇, 遠藤史郎, 具芳明, 青柳哲史, 八田益充, 山田充啓, 徳田浩一, 矢野寿一, 北川美穂, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　61st-59th　296　2012/09
本邦で分離されたメタロ‐β‐ラクタマーゼ産生大腸菌についての検討

矢野寿一, 小川美保, 遠藤史郎, 金森肇, 角田梨紗子, 猪股真也, 霜島正浩, 石橋令臣, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 國島広之, 北川美穂, 平潟洋一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　61st-59th　125　2012/09
東北大学病院で分離された基質特異性拡張型β-ラクタマーゼ産生大腸菌に関する検討

矢野寿一, 平瀉洋一, 新井和明, 遠藤史郎, 金森肇, 猪股真也, 石橋令臣, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

日本化学療法学会雑誌　60　(Suppl.A)　319-319　2012/03/26
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
長野県諏訪地域における外来抗菌薬の使用状況と季節変動の検討

具芳明, 遠藤史郎, 青柳哲史, 八田益充, 山田充啓, 新井和明, 徳田浩一, 矢野寿一, 國島広之, 北川美穂, 平瀉洋一, 賀来満夫

感染症学雑誌　86　(臨増)　283-283　2012/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
東北大学病院において血液培養から分離されたAcinetobacter spp.の分離頻度

遠藤史郎, 矢野寿一, 笹野美奈, 猪股真也, 石橋令臣, 新井和明, 具芳明, 青柳哲史, 八田益充, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 平瀉洋一, 賀来満夫

感染症学雑誌　86　(臨増)　303-303　2012/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
血液培養から分離されたカルバペネム耐性Acinetobacter soliの耐性遺伝子の解析

笹野美奈, 遠藤史郎, 矢野寿一, 猪股真也, 石橋令臣, 新井和明, 具芳明, 青柳哲史, 八田益充, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 平瀉洋一, 賀来満夫

日本化学療法学会雑誌　60　(Suppl.A)　228-228　2012/03
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
A群溶血性連鎖球菌における病原因子の遺伝子解析

新井和明, 平瀉洋一, 矢野寿一, 遠藤史郎, 金森肇, 石橋令臣, 猪股真也, 長沢光章, 阿部裕子, 北川美穂, 青柳哲史, 八田益充, 具芳明, 山田充啓, 徳田浩一, 國島広之, 賀来満夫

感染症学雑誌　86　(臨増)　394-394　2012/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
2011年東日本大震災直後の東北大学病院における感染症症例の解析

青柳哲史, 山田充啓, 國島広之, 徳田浩一, 矢野寿一, 石橋令臣, 八田益充, 遠藤史郎, 新井和明, 猪股真也, 具芳明, 金森肇, 北川美穂, 平瀉洋一, 賀来満夫

感染症学雑誌　86　(臨増)　508-508　2012/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
東日本大震災での避難所における衛生状態及び感染症リスク要因の検討

徳田浩一, 國島広之, 遠藤史郎, 八田益充, 金森肇, 石橋令臣, 新井和明, 具芳明, 猪股真也, 青柳哲史, 山田充啓, 北川美穂, 矢野寿一, 平瀉洋一, 賀来満夫

感染症学雑誌　86　(臨増)　512-512　2012/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
miR-200/miR-21は肺胞上皮細胞のEMTを制御する

山田充啓, 久保裕司, 鈴木隆哉, 藤野直也, 大田千春, 高橋徹, 國島広之, 青柳哲史, 賀来満夫

日本呼吸器学会誌　1　(増刊)　242-242　2012/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
Communicable diseases after the disasters: With the special reference to the Great East Japan Earthquake

Kentaro Iwata, Goh Ohji, Hideaki Oka, Yoshihiro Takayama, Tetsuji Aoyagi, Yoshiaki Gu, Masumitsu Hatta, Koichi Tokuda, Mitsuo Kaku

Journal of Disaster Research　7　(6)　746-753　2012
Publisher: Fuji Technology Press
DOI： 10.20965/jdr.2012.p0746 　

ISSN： 1883-8030 1881-2473

eISSN： 1883-8030
東日本大震災後に宮城県名取市館腰小学校の避難所において発生したA型インフルエンザアウトブレイク事例への対応支援

遠藤史郎, 徳田浩一, 國島広之, 石橋令臣, 猪俣真也, 新井和明, 具芳明, 青柳哲史, 八田益充, 山田充啓, 矢野寿一, 北川美穂, 平潟洋一, 賀来満夫

日本環境感染学会誌　27　(Suppl.)　152-152　2012/01
Publisher: (一社)日本環境感染学会
ISSN： 1882-532X

eISSN： 1883-2407
【知っておきたい、見落としやすい、危険な感染症】血管留置カテーテル感染 (救急医学)

青柳哲史, 國島広之, 賀来満夫

救急医学　36　(5)　579-582　2012
国内で分離されたCitrobacter属の基質特異性拡張型β‐ラクタマーゼ(ESBL)に関する分子疫学的研究

金森肇, 矢野寿一, 平瀉洋一, 新井和明, 遠藤史郎, 小川美保, 霜島正浩, 青柳哲史, 八田益充, 山田充啓, 具芳明, 徳田浩一, 國島広之, 北川美穂, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　60th-58th　165　2011/09
東日本で分離された基質特異性拡張型β-ラクタマーゼ産生大腸菌に関する検討

矢野寿一, 黒田仁, 平潟洋一, 新井和明, 金森肇, 遠藤史郎, 霜島正浩, 小川美保, 石橋令臣, 青柳哲史, 八田益充, 西巻雄司, 山田充啓, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

日本化学療法学会雑誌　59　(Suppl.A)　160-160　2011/06/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
国内におけるAcinetobacter spp.の疫学的解析

遠藤史郎, 矢野寿一, 平潟洋一, 金森肇, 新井和明, 小川美保, 霜島正浩, 石橋令臣, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 徳田浩一, 北川美穂, 國島広之, 賀来満夫

日本化学療法学会雑誌　59　(Suppl.A)　181-181　2011/06/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
マクロライド耐性A群溶血性連鎖球菌における耐性関連遺伝子と表現型の検討

新井和明, 平潟洋一, 矢野寿一, 黒田仁, 遠藤史郎, 金森肇, 青柳哲史, 石橋令臣, 阿部裕子, 長沢光章, 北川美穂, 八田益光, 山田充啓, 西巻雄司, 徳田浩一, 國島広之, 賀来満夫

日本化学療法学会雑誌　59　(Suppl.A)　187-187　2011/06/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
院内発症の血流感染症診断におけるプロカルシトニン定量測定の意義

青柳哲史, 國島広之, 阿部裕子, 長沢光章, 石橋令臣, 金森肇, 遠藤史郎, 八田益充, 山田充啓, 西巻雄司, 徳田浩一, 北川美穂, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

感染症学雑誌　85　(臨増)　279-279　2011/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Panton-Valentine leucocidin(PVL)陽性MRSAによる難治性慢性中耳炎の一例

武井健太郎, 矢野寿一, 平潟洋一, 新井和明, 金森肇, 遠藤史郎, 石橋令臣, 青柳哲史, 八田益充, 西巻雄司, 山田充啓, 徳田浩一, 北川美穂, 阿部裕子, 長沢光章, 國島広之, 賀来満夫

感染症学雑誌　85　(臨増)　312-312　2011/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
急性肺損傷における肺好中球上CXCR4発現上昇の機序とその役割

山田充啓, 久保裕司, 何梅, 鈴木隆哉, 藤野直也, 國島広之, 西巻雄司, 青柳哲史, 平潟洋一, 賀来満夫

日本呼吸器学会雑誌　49　(増刊)　149-149　2011/03
Publisher: (一社)日本呼吸器学会
ISSN： 1343-3490
Expression Patterns Of Two Important Regulatory Micrornas In Epithelial-Mesenchymal Transition During Experimental Bleomycin-Induced Lung Fibrosis

M. Yamada, H. Kubo, N. Fujino, M. He, T. Suzuki, T. Takahashi, C. Ota, T. Aoyagi, H. Kunishima, M. Yamaya, M. Kaku

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　183　2011

ISSN： 1073-449X

eISSN： 1535-4970
肺炎球菌の認識と感染防御におけるDectin‐2の役割

赤堀ゆきこ, 青柳哲史, 八田益充, 石井恵子, 西城忍, 岩倉洋一郎, 山崎晶, 賀来満夫, 川上和義

日本生体防御学会学術総会講演抄録集　22nd　60　2011
Emergence of fluoroquinolone-resistant Streptococcus pyogenes in Japan by a point mutation leading to a new amino acid substitution. International-journal

Arai Kazuaki, Hirakata Yoichi, Yano Hisakazu, Kanamori Hajime, Endo Shiro, Hirotani Ayako, Abe Yuko, Nagasawa Mitsuaki, Kitagawa Miho, Aoyagi Tetsuji, Hatta Masumitsu, Yamada Mitsuhiro, Nishimaki Katsushi, Takayama Yoko, Yamamoto Natsuo, Kunishima Hiroyuki, Kaku Mitsuo

J Antimicrob Chemother　66　(3)　494-498　2011

DOI： 10.1093/jac/dkq477 　

ISSN： 0305-7453

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OBJECTIVES: Streptococcus pyogenes causes various diseases in humans. While the prevalence of fluoroquinolone-resistant S. pyogenes isolates has been increasing since 2000 in the USA and Europe, it has remained very low in Japan. We isolated a fluoroquinolone-resistant S. pyogenes strain and analysed its genetics. METHODS: TU-296, a strain of S. pyogenes resistant to levofloxacin (MIC 16 mg/L), was isolated from the throat of a patient in their thirties with pharyngitis in autumn 2007. We carried out susceptibility tests for various antimicrobial agents and PCR analysis of the genes gyrA, gyrB, parC and parE in the quinolone resistance-determining region, followed by sequencing of the PCR products to find mutation(s) and the resulting amino acid substitution(s). We then sequenced the PCR product of the emm gene and determined the emm genotype. RESULTS: S. pyogenes TU-296 was found to have the following mutations and amino acid substitutions: adenine 476 to cytosine in gyrA and cytosine 367 to thymine in parC, resulting in Glu-85→Ala in GyrA and Ser-79→Phe in ParC. The genotype of the isolate was emm11. CONCLUSIONS: Amino acid substitutions in fluoroquinolone-resistant S. pyogenes have already been reported from Europe and the USA, including Ser-81→Phe or Tyr and Met-99→Leu in GyrA, as well as Ser-79→Phe, Tyr or Ala and others in ParC. Numerous point mutations were found in parC and parE of S. pyogenes TU-296. In addition, a new amino acid substitution was detected (Glu-85→Ala in GyrA). To our knowledge, there have been no previous reports of this substitution in a clinical isolate of S. pyogenes.
本邦で分離されたEnterobacter属における基質特異性拡張型β‐ラクタマーゼ(ESBL)産生状況

矢野寿一, 平潟洋一, 新井和明, 金森肇, 遠藤史郎, 高山陽子, 霜島正浩, 小川美保, 石橋令臣, 青柳哲史, 八田益充, 西巻雄司, 山田充啓, 北川美穂, 國島広之, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　59th-57th　133　2010/09
国内におけるカルバペネム耐性Acinetobacter spp.の疫学的解析

遠藤史郎, 矢野寿一, 平潟洋一, 金森肇, 新井和明, 高山陽子, 小川美保, 霜島正浩, 阿部裕子, 石橋令臣, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 北川美穂, 國島広之, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　59th-57th　156　2010/09
血流感染診断におけるプロカルシトニン定量測定の有用性

青柳哲史, 國島広之, 阿部裕子, 長沢光章, 石橋令臣, 金森肇, 遠藤史郎, 八田益充, 山田充浩, 西巻雄司, 高山陽子, 北川美穂, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　59th-57th　151　2010/09
咽頭より分離されたGyrAの85にアミノ酸置換をもつフルオロキノロン耐性Streptococcus pyogenesの分子疫学的検討

新井和明, 矢野寿一, 黒田仁, 金森肇, 遠藤史郎, 青柳哲史, 石橋令臣, 阿部裕子, 長沢光章, 北川美穂, 八田益充, 山田充啓, 西巻雄司, 高山陽子, 山本夏男, 國島広之, 平瀉洋一, 賀来満夫

日本化学療法学会雑誌　58　(Suppl.A)　267-267　2010/04/28
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
フィリピンで分離された基質特異性拡張型β-ラクタマーゼ(ESBL)産生グラム陰性桿菌の検討

金森肇, 矢野寿一, 新井和明, 石橋令臣, 遠藤史郎, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 高山陽子, 山本夏男, 北川美穂, 國島広之, 平瀉洋一, 賀来満夫

日本化学療法学会雑誌　58　(Suppl.A)　249-249　2010/04/28
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
市中感染型MRSAの気道上皮培養細胞への侵入性に関する検討

高山陽子, 矢野寿一, 遠藤史郎, 新井和明, 石橋令臣, 金森肇, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 山本夏男, 北川美穂, 國島広之, 平瀉洋一, 賀来満夫

日本化学療法学会雑誌　58　(Suppl.A)　361-361　2010/04/28
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
新型インフルエンザを含めた感染対策に対する本学学生の意識調査

高山陽子, 遠藤史郎, 石橋令臣, 金森肇, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 山本夏男, 北川美穂, 國島広之, 森兼啓太, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

感染症学雑誌　84　(1)　127-128　2010/01
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
Autotaxin Is Involved In Pulmonary Edema During Acid-induced Acute Lung Injury

M. Yamada, H. Kubo, S. Okudaira, T. Suzuki, N. Fujino, M. He, N. Yamamoto, T. Aoyagi, H. Kunishima, J. Aoki, M. Yamaya, M. Kaku

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　181　2010

ISSN： 1073-449X
Cell-associated Haemophilus influenzaeに対する各種抗菌薬の殺菌効果

矢野寿一, 平潟洋一, 新井和明, 金森肇, 遠藤史郎, 山崎善隆, 廣谷綾子, 青柳哲史, 石橋令臣, 八田益充, 山田充啓, 高山陽子, 西巻雄司, 山本夏男, 北川美穂, 國島広之, 森兼啓太, 賀来満夫

日本化学療法学会雑誌　58　(1)　60-60　2010/01
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
Monolayer culture systems with respiratory epithelial cells for evaluation of bacterial invasiveness. (Tohoku J Exp Med)

Hirakata Yoichi, Yano Hisakazu, Arai Kazuaki, Endo Shiro, Kanamori Hajime, Aoyagi Tetsuji, Hirotani Ayako, Kitagawa Miho, Hatta Masumitsu, Yamamoto Natsuo, Kunishima Hiroyuki, Kawakami Kazuyoshi, Kaku Mitsuo

Tohoku J Exp Med　220　(1)　15-19　2010
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.220.15 　

ISSN： 0040-8727 1349-3329

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Pseudomonas (P.) aeruginosa is a major opportunistic pathogen especially in immunocompromised patients. To evaluate the invasiveness of respiratory pathogens, we developed monolayer culture systems and examined the degree of invasion by P. aeruginosa and invasive Salmonella (S.) typhimurium strains using human respiratory cell lines: A549 (derived from lung cancer), BEAS-2B (normal bronchial epithelium), and Calu-3 (pleural effusion of a patient with adenocarcinoma of the lung). Cells were seeded into filter units containing 0.33 cm² filter membranes with 3.0 μm pores, and were incubated at 37°C under 5% CO₂ for 4-10 days. By monitoring the trans-monolayer electrical resistance (TER), we judged that BEAS-2B cells (TER values: 436.2 ± 16.8 to 628.8 ± 66.3 Ω cm²) and Calu-3 cells (TER values: 490.5 ± 25.2 to 547.8 ± 21.6 Ω cm²) formed monolayers with tight junctions, but not A549 cells. On day 8 of culture, monolayer cultures were infected with bacteria, and the number of microorganisms penetrating into the basolateral medium was counted. Wild-type P. aeruginosa PAO1 (PAO1 WT) and S. typhimurium SL1344 were detected in the basolateral medium of BEAS-2B monolayer system by 3 h after inoculation, while only P. aeruginosa PAO1 WT was detected in the basolateral medium of Calu-3 monolayer, indicating poor invasiveness of S. typhimurium SL1344 in the Calu-3 system. These findings suggest that BEAS-2B or Calu-3 monolayer system could be useful for evaluating the invasiveness of respiratory pathogens. Because of the difference in bacterial invasiveness, we may need to choose a suitable cell system for each target pathogen.
【これだけは知っておきたい検査のポイント】細菌検査検体別同定検査各論血液培養検査

青柳哲史, 賀来満夫

Medicina　47　(11)　568-570　2010
インフルエンザ菌に対するタゾバクタム/ピペラシリンの抗菌活性およびキノロン耐性の解析

平潟洋一, 矢野寿一, 新井和明, 廣谷綾子, 石橋令臣, 金森肇, 遠藤史郎, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 高山陽子, 山本夏男, 國島広之, 阿部裕子, 長沢光章, 小林寅哲, 北川美穂, 川上和義, 賀来満夫

臨床病理　57　(補冊)　98-98　2009/07/28
Publisher: 日本臨床検査医学会
ISSN： 0047-1860
インフルエンザ菌に対するタゾバクタム/ピペラシリンの抗菌活性の他剤との比較および潜在するキノロン耐性菌についての検討

平潟洋一, 金森肇, 青柳哲史, 山本夏男, 國島広之, 賀来満夫

日本呼吸器学会雑誌　47　(増刊)　293-293　2009/05/10
Publisher: (一社)日本呼吸器学会
ISSN： 1343-3490
Enterobacter属における基質特異性拡張型β-ラクタマーゼ(ESBL)産生株の判定法についての検討

廣谷綾子, 平潟洋一, 矢野寿一, 新井和明, 國島広之, 高山陽子, 山本夏男, 八田益充, 北川美穂, 位田剣, 青柳哲史, 遠藤史郎, 金森肇, 勝見真琴, 阿部裕子, 佐藤延子, 長沢光章, 賀来満夫

日本化学療法学会雑誌　57　(Suppl.A)　219-219　2009/04/30
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
緑膿菌に対する各種抗菌薬の経時的minimal bacterial concentration(MBC)およびcell-associated bacteriaに対する殺菌効果

平潟洋一, 矢野寿一, 新井和明, 廣谷綾子, 國島広之, 山本夏男, 高山陽子, 八田益充, 北川美穂, 位田剣, 青柳哲史, 遠藤史郎, 金森肇, 長沢光章, 賀来満夫

日本化学療法学会雑誌　57　(Suppl.A)　223-223　2009/04/30
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
23価肺炎球菌ワクチンに対する液性免疫応答とnatural killer T細胞の役割に関する検討

宮坂智充, 青柳哲史, 内山美寧, 國島広之, 山本夏男, 平潟洋一, 石井恵子, 大石和徳, 賀来満夫, 川上和義, 中山俊憲

感染症学雑誌　83　(臨増)　140-140　2009/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
LPSを用いた新規急性肺傷害(ALI/ARDS)モデルマウスの作成とその病態解析

青柳哲史, 山本夏男, 位田剣, 八田益充, 國島広之, 矢野寿一, 平潟洋一, 賀来満夫, 川上和義, 中山俊憲

感染症学雑誌　83　(臨増)　258-258　2009/03
Publisher: (一社)日本感染症学会
ISSN： 0387-5911
感染症陰圧病床での入院管理が必要と判断された帯状疱疹症13例の検討

山本夏男, 国島広之, 八田益充, 位田剣, 金森肇, 遠藤史郎, 青柳哲史, 平潟洋一, 賀来満夫

日本内科学会雑誌　98　(Suppl.)　161-161　2009/02/20
Publisher: (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
インフルエンザ菌に対するタゾバクタム/ピペラシリンの抗菌活性およびキノロン耐性の解析

平潟洋一, 国島広之, 山本夏男, 位田剣, 青柳哲史, 遠藤史郎, 金森肇, 新井和明, 矢野寿一, 賀来満夫

日本内科学会雑誌　98　(Suppl.)　163-163　2009/02/20
Publisher: (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
Analysis of Inflammatory Responses in Acutely Injured Lungs Using a Novel Mouse Model of ALI/ARDS.

T. Aoyagi, N. Yamamoto, M. Kaku, K. Kawakami

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　179　2009

ISSN： 1073-449X
Transfer therapy of Immune B-1 cells triggered by activated iNKT cells for acute lung infection with S. pneumoniae.

N. Yamamoto, S. M. Kerfoot, T. Aoyagi, K. Inden, M. Hatta, H. Kunishima, Y. Hirakata, K. Kawakami, M. Kaku, P. W. Askenase

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　179　2009

ISSN： 1073-449X
新型インフルエンザを含めた感染対策に対する本学学生の意識調査

高山陽子, 遠藤史郎, 石橋令臣, 金森肇, 青柳哲史, 八田益充, 山田充啓, 西巻雄司, 山本夏男, 北川美穂, 國島広之, 森兼啓太, 新井和明, 矢野寿一, 平潟洋一, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　58th-56th　149　2009
Measurement of (1-3)-beta-D-glucan derived from different gauze types.

Kanamori Hajime, Kanemitsu Keiji, Miyasaka Tomomitsu, Ameku Koken, Endo Shiro, Aoyagi Tetsuji, Inden Ken, Hatta Masumitsu, Yamamoto Natsuo, Kunishima Hiroyuki, Yano Hisakazu, Kaku Koki, Hirakata Yoichi, Kaku Mitsuo

Tohoku J Exp Med　217　(2)　117-121　2009

DOI： 10.1620/tjem.217.117 　

ISSN： 0040-8727 1349-3329
Early production of tumor necrosis factor-alpha by Gr-1(+) cells and its role in the host defense to pneumococcal infection in lungs. (FEMS Immunol Med Microbiol)

Hatta M, Yamamoto N, Miyazato A, Ishii N, Nakamura K, Inden K, Aoyagi T, Kunishima H, Hirakata Y, Suzuki K, Kaku M, Kawakami K

FEMS Immunol Med Microbiol　58　(2)　182-192　2009

DOI： 10.1111/j.1574-695X.2009.00616.x 　

ISSN： 0928-8244
大学院学生における針刺し切創・体液曝露事例の現状

國島広之, 山本夏男, 天久康絢, 金森肇, 遠藤史郎, 青柳哲史, 位田剣, 北川美穂, 矢野寿一, 平潟洋一, 加來浩器, 賀来満夫

日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　57th-55th　163　2008/10/01
レジオネラ (特集市中肺炎--症例と指針で学ぶガイドラインの実際) -- (迅速診断法の利点・問題点)

青柳哲史, 川上和義

感染と抗菌薬　11　(3)　264-267　2008/09
Publisher: ヴァンメディカル
ISSN： 1344-0969
Toll-like receptor 4-dependent activation of myeloid dendritic cells by leukocidin of Staphylococcus aureus. International-journal

Inden K, Kaneko J, Miyazato A, Yamamoto N, Mouri S, Shibuya Y, Nakamura K, Aoyagi T, Hatta M, Kunishima H, Hirakata Y, Itoh Y, Kaku M, Kawakami K

Microbes Infect　11　(2)　in print-53　2008

DOI： 10.1016/j.micinf.2008.11.013 　

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Leukocidin (Luk), an exotoxin of Staphylococcus aureus consisting of LukF and LukS, is a hetero-oligomeric pore-forming cytolytic toxin toward human and rabbit polymorphonuclear leukocytes. However, it is uncertain how Luk affects the host immune response. In the present study, we investigated whether Luk has the ability to stimulate mouse bone marrow-derived myeloid dendritic cells (BM-DCs). LukF activated BM-DCs to generate IL-12p40 mRNA, induce intracellular expression and extracellular secretion of this cytokine and express CD40 on their surface, whereas LukS showed a much lower or marginal ability in the activation of BM-DCs than its counterpart component. Similarly, TNF-alpha was secreted by BM-DCs upon stimulation with these components. Combined addition of these components did not lead to a further increase in IL-12p40 secretion. IL-12p40 production caused by LukF was completely abrogated in BM-DCs from TLR4-deficient mice similarly to the response to lipopolysaccharide (LPS). Polymixin B did not affect the LukF-induced IL-12p40 production, although the same treatment completely inhibited the LPS-induced response. Boiling significantly inhibited the response caused by LukF, but not by LPS. Finally, in a luciferase reporter assay, LukF induced the activation of NF-kappaB in HEK293T cells transfected with TLR4, MD2 and CD14, whereas LukS did not show such activity. These results demonstrate that LukF caused the activation of BM-DCs by triggering a TLR4-dependent signaling pathway and suggests that Luk may affect the host inflammatory response as well as show a cytolytic effect on leukocytes.
クリプトコッカスによるCD1dに依存したiNKT細胞活性化機構の解析

位田剣, 仲村究, 八田益充, 青柳哲史, 宮里明子, 賀来満夫, 川上和義

日本免疫学会総会・学術集会記録　37　280-280　2007
Cryptococcus neoformans由来DNAによる樹状細胞活性化機序の解析

仲村究, 宮里明子, 肖剛, 八田益充, 青柳哲史, 位田剣, 西城忍, 岩倉洋一郎, 竹田潔, 審良静男, 鈴木和男, 賀来満夫, 川上和義

日本免疫学会総会・学術集会記録　37　280-280　2007
肺炎球菌感染初期防御におけるTNFα産生細胞の解析

八田益充, 仲村究, 位田剣, 青柳哲史, 宮里明子, 賀来満夫, 川上和義

日本免疫学会総会・学術集会記録　37　246-246　2007
23価肺炎球菌ワクチン接種症例における自然免疫リンパ球の動態に関する検討

青柳哲史, 内山美寧, 國島広之, 八田益充, 仲村究, 位田剣, 宮里明子, 伊藤俊広, 中山俊憲, 賀来満夫, 川上和義

日本免疫学会総会・学術集会記録　37　207-207　2007

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Research Projects 11

Development of a novel COVID-19 intranasal vaccine using the adjuvant function of iron oxide nanoparticles

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2025/04/01 - 2028/03/31
Development of Novel Antimicrobial Peptide based on CopW for Antimicrobacterial Resistant Pathogens

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2025/04/01 - 2028/03/31
粘膜免疫を誘導可能な酸化鉄ナノ粒子を基盤とした新規肺炎球菌多価ワクチンの開発

佐藤光, 石井恵子, 青柳哲史

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
Development of novel cationitic antimicrobial peptides with D-amino acid against resipratory infection by drug-resistant bacteria

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Toho University

2022/04/01 - 2025/03/31
Control of implantable ventricular assist device driveline exit site infection by infrared irradiation

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2021/04/01 - 2024/03/31
Establishment and utilization of an infectious disease crisis management system based on Field Epidemiology including post COVID-19

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku Medical and Pharmaceutical University

2021/04/01 - 2024/03/31
The Novel IL-1 Cytokines Family Members in Severe Infectious Diseases

AOYAGI TETSUJI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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This study aims to investigate the role of IL-36 cytokines in sepsis. We found that the concentration of IL-36gamma elevated in the patients with sepsis,and IL-36Ra packed in extracellular vesicles was released from neutrophils. IL-36gamma enhanced inflammation in inflammatory cells and coagulation and cell injury in endothelial cells. Whereas, IL-36Ra inhibited IL-36gamma induced inflammation, coagulation and cell injury.Indicating that IL-36 cytokines deeply involved in the pathogenesis of sepsis. Finally, we confirmed that IL-36Ra is a potential therapeutic candidate for sepsis using a sepsis mouse model.
The role of claudins in the lung fibrosis post influenza virus-induced acute lung injury

Aoyagi Tetsuji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The clinical course and pathophysiological feature of ARDS are characterized as three phases: acute exduative, proliferative and fibrotic. We investigated the role of claudins, a family of proteins in the components of the tight junction, in acute and fibrotic phase of lung injury. We induced nonviral ARDS by alpha-galactosylceramide(GalCer) and LPS and viral ARDS by influenza virus infection. Claudin-5 and -18 are expressed in naive lungs. In both ARDS model, expression of claudin-4 was elevated and claudin-18 mRNA decreased in acute phases of lung injury. Claudin-4 was expressed in not only epithelial cells but leukocytes recruited into the lungs. Micorparticles in BAL fluid after influenza virus infection was observed. Influenza virus induced MPs have a potential to induced the cytokines and chemokines in alveolar machrophasge. These results indicated that claudins may be involved in the pathogenesis of acute phase of lung injury.
Risk assessment for the facility and pathogens in the hospital environment.

KUNISHIMA Hiroyuki, TOKUDA Koichi, HATTA Masumitsu, AOYAGI Tetsuji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

2011/04/28 - 2015/03/31

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In recent years, environment of medical facilities, it is recognized that it becomes the risk in cross-infection as for the site felt well and the air. We conducted risk assessment as Hospital flora in this study using air sampling and ATP among general hospital, outpatient clinic including dentistry, a long-term care facilities. Multi-drug resistant pathogens (ex. MRCNS) were detected in environment in the general hospital, and, in addition, an outbreak due to an air conditioner might occur. In facility management for the medical facilities, periodical monitoring is recommend.
Role of Innate immunity on the exacerbation of bronchial asthma via influenza virus infection

AOYAGI Tetsuji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2011 - 2012

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Influenza virus is the reason of acute exacerbation bronchial asthma. However, it was lack of understanding for this mechanism. First, we have utilized mouse models of bronchial asthma induced by ovalbumin to experimentally examine a possible aggregation between influenza virus and asthma. We could not find any difference of clinical outcome, accumulation of inflammatory cells and Th1/Th2 related cytokines between normal and asthma mouse after influenza virus infection. We, next, examined whether tissue remodeling was observed after severe inflammation by influenza virus infection. Mice were inoculated non-lethal dose of influenza virus, histopathological analysis presented bronchiectasis and peribronchial collagen diposition and collagen level in the lung was significantly elevated compared to normal mice at the day 35 post-infection. This model could be a novel experimental tool for approaching the pathogenic mechanism of bronchial remodeling after sever inflammation.
Involvement of claudin-network in the development of ARDS caused by influenza virus infection

KAWAKAMI Kazuyoshi, SUZUKI Kazuo, AOYAGI Tetsuji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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We addressed the possible involvement of claudins in the development of acute lung injury. In a real-time PCR analysis, expression of cluadin 2 and 4 was increased in the injured lungs, whereas that of claudin 5, 6, 9 and 18-1 was reduced. In an immunohistochemical analysis, expression of claudin 2 and 4 was detected in the bronchoepithelial cells of injured lungs. Lung edema caused by LPS administration tended to be worsened in claudin4 gene-disrupted mice. These results suggest that claudins may be involved in thedevelopment of ARDS.

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