PHOTO

Yoichi Haga
Section
Graduate School of Biomedical Engineering
Job title
Professor
Degree

  • 博士（医学）（東北大学）

  • 博士（工学）（東北大学）

Education 1

  • Tohoku University　Faculty of Medicine　医学科

    - 1992/03

Committee Memberships 56

  • マイクロマシンセンター MEMSフロンティアとしてのナノ・バイオ融合による未来デバイス技術に関する調査研究委員会」　マイクロマシンセンター MEMSフロンティアとしてのナノ・バイオ融合による未来デバイス技術に関する調査研究委員会」ホワイトデバイスWG（分科会）の委員及び研究員

    2006/06 - Present

  • マイクロマシンセンター MEMSフロンティアとしてのナノ・バイオ融合による未来デバイス技術に関する調査研究委員会」　マイクロマシンセンター MEMSフロンティアとしてのナノ・バイオ融合による未来デバイス技術に関する調査研究委員会」ホワイトデバイスWG（分科会）の委員及び研究員

    2006/06 - Present

  • 電気学会　バイオ・マイクロシステム技術委員会 マイクロ技術利用先進医療調査専門委員会

    2005/12 - Present

  • 電気学会　バイオ・マイクロシステム技術委員会 マイクロ技術利用先進医療調査専門委員会

    2005/12 - Present

  • 電気学会　バイオ・マイクロシステム技術委員会 幹事

    2005/03 - Present

  • 電気学会　バイオ・マイクロシステム技術委員会 幹事

    2005/03 - Present

  • 独立行政法人医薬品医療機器総合機構(PMDA)科学委員会専門部会　独立行政法人医薬品医療機器総合機構(PMDA)科学委員会専門部会委員

    2012/09 - 2014/03

  • 独立行政法人医薬品医療機器総合機構(PMDA)科学委員会専門部会　独立行政法人医薬品医療機器総合機構(PMDA)科学委員会専門部会委員

    2012/09 - 2014/03

  • コミュニケーション支援委員会　コミュニケーション支援委員会 委員

    2008/05 - 2010/03

  • コミュニケーション支援委員会　コミュニケーション支援委員会 委員

    2008/05 - 2010/03

  • 電気学会マイクロマシン・センサシステム技術委員会 MEMSの医療応用に関する調査専門委員会　電気学会マイクロマシン・センサシステム技術委員会 MEMSの医療応用に関する調査専門委員会委員

    2007/08 - 2009/03

  • 電気学会マイクロマシン・センサシステム技術委員会 MEMSの医療応用に関する調査専門委員会　電気学会マイクロマシン・センサシステム技術委員会 MEMSの医療応用に関する調査専門委員会委員

    2007/08 - 2009/03

  • 日本生体医工学会東北支部　日本生体医工学会東北支部 幹事

    2007/04 - 2009/03

  • 日本生体医工学会東北支部　日本生体医工学会東北支部 幹事

    2007/04 - 2009/03

  • 異分野融合型次世代デバイス製造技術開発プロジェクト（BEANSプロジェクト）技術研究委員会　異分野融合型次世代デバイス製造技術開発プロジェクト（BEANSプロジェクト）技術研究委員会Academia WG 委員

    2008/04 - 2008/12

  • 異分野融合型次世代デバイス製造技術開発プロジェクト（BEANSプロジェクト）技術研究委員会　異分野融合型次世代デバイス製造技術開発プロジェクト（BEANSプロジェクト）技術研究委員会Academia WG 委員

    2008/04 - 2008/12

  • MEMSの技術戦略マップローリングのタスクフォース委員会　MEMSの技術戦略マップローリングのタスクフォース委員会委員

    2007/12 - 2008/12

  • MEMSの技術戦略マップローリングのタスクフォース委員会　MEMSの技術戦略マップローリングのタスクフォース委員会委員

    2007/12 - 2008/12

  • 日本生体医工学会「生体医工学シンポジウム2008」　日本生体医工学会「生体医工学シンポジウム2008」 プログラム委員

    2008/05 - 2008/09

  • 日本生体医工学会「生体医工学シンポジウム2008」　日本生体医工学会「生体医工学シンポジウム2008」 プログラム委員

    2008/05 - 2008/09

  • 電気学会Ｅ部門総合研究会　電気学会Ｅ部門総合研究会 実行委員

    2007/10 - 2008/06

  • 電気学会Ｅ部門総合研究会　電気学会Ｅ部門総合研究会 実行委員

    2007/10 - 2008/06

  • 第46回日本生体医工学会大会　実行委員

    2007/03 - 2007/12

  • 第46回日本生体医工学会大会　実行委員

    2007/03 - 2007/12

  • 日本生体医工学会「生体医工学シンポジウム2007」　日本生体医工学会「生体医工学シンポジウム2007」 プログラム委員

    2007/05 - 2007/09

  • 日本生体医工学会「生体医工学シンポジウム2007」　日本生体医工学会「生体医工学シンポジウム2007」 プログラム委員

    2007/05 - 2007/09

  • 平成19年度「国際マイクロマシン・ナノテクシンポジウム」 プログラム委員会　平成19年度「国際マイクロマシン・ナノテクシンポジウム」 プログラム委員会委員

    2007/04 - 2007/08

  • 平成19年度「国際マイクロマシン・ナノテクシンポジウム」 プログラム委員会　平成19年度「国際マイクロマシン・ナノテクシンポジウム」 プログラム委員会委員

    2007/04 - 2007/08

  • 電気学会　E準部門総合研究会 実行委員

    2006/04 - 2007/03

  • 電気学会　E準部門総合研究会 実行委員

    2006/04 - 2007/03

  • 日本生体医工学会　「生体医工学シンポジウム2006」 プログラム委員

    2006/05 - 2006/09

  • 日本生体医工学会　「生体医工学シンポジウム2006」 プログラム委員

    2006/05 - 2006/09

  • 電気学会マイクロマシン・センサー技術委員会　ナノメータ変位アクチュエータ調査専門委員会 委員

    2003/06 - 2006/05

  • 電気学会マイクロマシン・センサー技術委員会　ナノメータ変位アクチュエータ調査専門委員会 委員

    2003/06 - 2006/05

  • 独立行政法人農業・生物系特定産業技術研究機構　「新技術・新分野創出のための基礎研究推進事業」に係る事後評価専門委員

    2006/01 - 2006/03

  • 独立行政法人農業・生物系特定産業技術研究機構　「新技術・新分野創出のための基礎研究推進事業」に係る事後評価専門委員

    2006/01 - 2006/03

  • 日本コンピュータ外科学会　評議員

    2002/04 - 2006/03

  • 日本コンピュータ外科学会　評議員

    2002/04 - 2006/03

  • 日本生体医工学会　「生体医工学シンポジウム2005」 プログラム委員

    2005/05 - 2005/09

  • 日本生体医工学会　「生体医工学シンポジウム2005」 プログラム委員

    2005/05 - 2005/09

  • 日本エム・イー学会　「生体医工学シンポジウム2004」 プログラム委員

    2004/05 - 2004/09

  • 日本エム・イー学会　「生体医工学シンポジウム2004」 プログラム委員

    2004/05 - 2004/09

  • 日本エム・イー学会　研究奨励賞選定委員会委員

    2003/10 - 2004/05

  • 日本エム・イー学会　論文賞選定委員会委員

    2003/10 - 2004/05

  • 日本エム・イー学会　研究奨励賞選定委員会委員

    2003/10 - 2004/05

  • 日本エム・イー学会　論文賞選定委員会委員

    2003/10 - 2004/05

  • 独立行政法人農業・生物系特定産業技術研究機構　「新技術・新分野創出のための基礎研究推進事業」に係る中間評価専門委員

    2003/11 - 2004/03

  • 独立行政法人農業・生物系特定産業技術研究機構　「新技術・新分野創出のための基礎研究推進事業」に係る中間評価専門委員

    2003/11 - 2004/03

  • 日本エム・イー学会　評議員

    2002/04 - 2004/03

  • 日本エム・イー学会　評議員

    2002/04 - 2004/03

  • 日本エム・イー学会　評議員

    2002/04 - 2003/03

  • 日本エム・イー学会　評議員

    2002/04 - 2003/03

  • 久光製薬株式会社 社内セミナー　講師

    2013/05 -

  • 久光製薬株式会社 社内セミナー　講師

    2013/05 -

  • 「イノベーション創出基礎的研究推進事業」書類審査専門　「イノベーション創出基礎的研究推進事業」書類審査専門委員

    2009/03 -

  • 「イノベーション創出基礎的研究推進事業」書類審査専門　「イノベーション創出基礎的研究推進事業」書類審査専門委員

    2009/03 -

Show all ︎Show first 5

Professional Memberships 14

  • The 19th International Conference of Society for Medical Innovation and Technology(2007/04-2007/12 Progamme Committee )

  • MEMSフロンティアとしてのナノ・バイオ融合による未来デバイス技術の調査研究委員会(2006/04-2007/03 ホワイトデバイスWG委員)

  • 電気学会(2006/04-2007/03 E準部門総合研究会 実行委員)

  • 独立行政法人農業・生物系特定産業技術研究機構(2006/01-2006/03 事後評価専門委員)

  • 日本生体医工学会(2005/05-2006/03 生体医工学シンポジウム2005 プログラム委員)

  • 電気学会(2005/04-2006/03 バイオマイクロシステム技術委員会 幹事)

  • 社団法人日本エム・イー学会(2004/05-2005/03 生体医工学シンポジウム2004 プログラム委員)

  • 独立行政法人農業・生物系特定産業技術研究機構(2003/11-2004/03 中間評価専門委員)

  • 社団法人日本エム・イー学会(2003/10-2004/03 論文賞選定委員会委員)

  • 社団法人日本エム・イー学会(2003/10-2004/03 研究奨励賞選定委員会委員)

  • 電気学会(2003/06-2006/05 マイクロマシン・センサー技術委員会・ナノメータ変位アクチュエータ調査専門委員会委員)

  • 社団法人日本エム・イー学会(2002/11-2003/03 選奨委員会、論文賞・阪本賞選定委員会委員)

  • 日本コンピュータ外科学会(2002/04-2006/03 評議員)

  • 日本エム・イー学会(2002/04-2003/03 評議員)

︎Show all ︎Show first 5

Research Areas 2

  • Life sciences / Biomaterials /

  • Life sciences / Biomedical engineering /

Awards 5

  1. 平成24年(第68回) 電気学会 電気学術振興賞 (進歩賞)

    2012/05/24　電気学会

  2. 平成１８年度日本生体医工学会（旧：日本エム・イー学会）論文賞・阪本賞

    2007/04/26　日本生体医工学会（旧：日本エム・イー学会）

  3. 2003年度日本機械学会ロボティクス・メカトロニクス部門福祉工学シンポジウムプレゼンテーション賞

    2004/09/14　社団法人日本機械学会　形状記憶合金マイクロアクチュエータを用いた視覚障害者用２次元ピンディスプレイ

  4. 2003年度日本コンピュータ外科学会講演論文賞

    2004/03/30　日本コンピュータ外科学会　形状記憶合金を用いた腸閉塞治療用能動屈曲チューブ

  5. 2002年度JSAO-Grant受賞

    2002/10/03　日本人工臓器学会JSAO　隔離性大動脈瘤エントリー部閉鎖プラグの開発

Papers 107

  1. Automatic irrigation system with a fiber-optic pressure sensor regulating intrapelvic pressure for flexible ureteroscopy

    Takashi Yoshida, Noriko Tsuruoka, Yoichi Haga, Hidefumi Kinoshita, Sang Seok Lee, Tadao Matsunaga

    Scientific Reports　13　(1)　2023/12

    DOI： 10.1038/s41598-023-47373-5 　

    eISSN：2045-2322

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    Increased intrapelvic pressure (IPP) due to irrigation during flexible ureteroscopy (f-URS) can pose a risk of postoperative severe urinary tract infection associated with pyelovenous backflow. An automatic regulation system for maintaining safe IPP levels could enable surgeons to perform f-URS safely without postoperative complications. This study aimed to assess the measurement accuracy of an ultra-miniature fiber-optic pressure sensor incorporated into a small-caliper ureteroscope for assessing IPP and to develop an automatic irrigation system linked to this sensor. A porcine kidney was used for the ex vivo experiment. The nephrostomy catheter, connected to the conventional pressure transducer, was placed on the renal pelvis to evaluate the actual IPP (a-IPP). For measuring IPP using the fiber-optic pressure sensor (fo-IPP) built into the f-URS, a diaphragm pressure sensor of Φ250 μm was used. To establish an irrigation system, the optimal proportional–integral–derivative (PID) controller was explored to accurately adjust the irrigation pump flow rate. A high correlation between a-IPP and fo-IPP was confirmed across irrigation pressure values of 60–180 mbar (all, r ≥ 0.7, p < 0.001). When performing bolus irrigation, although fo-IPP showed relatively a higher peak value than a-IPP, the response time of fo-IPP was equivalent to that of a-IPP. After PID parameter optimization, our automatic irrigation system based on fo-IPP smoothly and accurately regulated the intended IPP set in the 5–20 mmHg range without overshooting. We successfully developed and demonstrated an automatic irrigation system regulating IPP based on the PID controller for f-URS, utilizing a fiber-optic pressure sensor. Further research, including in vivo studies, will be needed to assess clinical feasibility.

  2. Batch fabrication of force sensors for robotic surgery using optical interference

    Yuki Kashimura, Noriko Tsuroka, Jumpei Arata, Yoichi Haga

    Sensors and Actuators A: Physical　362　2023/11/01

    DOI： 10.1016/j.sna.2023.114672 　

    ISSN：0924-4247

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    This paper aims to present a novel method for batch fabrication of miniature force sensors using optical interference with Microelectromechanical Systems technology. Previously, we noted that the batch fabrication of miniature force sensors was difficult because they were fabricated one by one using individual parts. Therefore, the present study proposes a new method for batch fabrication in a single batch, in which force sensors are assembled side-by-side. Furthermore, we demonstrate the performance and effectiveness of the proposed batch fabrication method to fabricate force sensors.

  3. Enzyme Electrode Sensor with Two-layer Bubble-removal Flow Channel for use Even in Negative-pressure Systems

    Tsuruoka Noriko, Tsugueda Kenta, Haga Yoichi

    IEEJ Transactions on Sensors and Micromachines　143　(9)　285-292　2023/09/01

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.143.285 　

    ISSN：1341-8939

    eISSN：1347-5525

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    In this research, an enzyme electrode sensor with a two-layer bubble-removal flow channel that can be used in a skin microperfusion system was fabricated. The first layer of the channel is placed on enzyme electrodes. The flow channel is connected to the second layer which has an outlet. A hydrophobic porous membrane is placed on the channel wall between the two layers on the inlet side of the electrodes. Thus, bubbles can bypass the electrodes by taking a shortcut through the hydrophobic porous membrane into the second layer. Since bubble removal results from the pressure difference between the layers, this flow channel can be used in both positive- and negative-pressure systems. The flow channel height and the pore size in the hydrophobic porous membrane were selected by measuring pressure differences between the two layers using different pumping methods. The bubble removal performance was evaluated during microperfusion measurements on porcine skin. In addition, the effect of the bubble-removal flow channel on lactate concentration measurements using an enzyme electrode was evaluated.

  4. Development of modified laser Doppler flowmetry device for real-time monitoring of esophageal mucosal blood flow: a preclinical assessment with an animal model

    Shun-Ichi Kawarai, Shintaro Katahira, Midori Miyatake, Kota Itagaki, Noriko Tsuruoka, Yoichi Haga, Yoshikatsu Saiki

    JOURNAL OF ARTIFICIAL ORGANS　2023/07

    Publisher: SPRINGER JAPAN KK

    DOI： 10.1007/s10047-023-01408-w 　

    ISSN：1434-7229

    eISSN：1619-0904

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    This study aimed to modify a laser Doppler flowmeter designed and assembled at our institute. After measuring sensitivity evaluation in ex vivo experiments, we confirmed the efficacy of this new device for monitoring real-time esophageal mucosal blood flow changes after thoracic stent graft implantation by simulating various clinical situations in an animal model. Thoracic stent graft implantation was performed in a swine model (n = 8). Esophageal mucosal blood flow decreased significantly from baseline (34.1 & PLUSMN; 18.8 ml/min/100 g vs. 16.7 & PLUSMN; 6.6 ml/min/100 g, P < 0.05) in the lower esophagus (Th6-Th8) where the stent graft covered the aorta. In the hemorrhagic shock model (shock index & GE; 1.0), esophageal mucosal blood flow showed a remarkable change from baseline in the upper esophagus (Th1-Th3), where the stent graft did not cover the aorta (20.8 & PLUSMN; 9.8 ml/min/100 g vs. 12.9 & PLUSMN; 8.6 ml/min/100 g, P < 0.01); however, it returned to the baseline value within a 30-min period. Mucosal blood flow remained stable in the esophagus, where the stent graft did not cover the aorta. After elevating the mean blood pressure to > 70 mmHg with continuous intravenous noradrenaline infusion, esophageal mucosal blood flow increased significantly in both regions; however, the reaction was different between the two regions. Our newly developed laser Doppler flowmeter could measure real-time esophageal mucosal blood flow changes in various clinical situations during thoracic stent graft implantation in a swine model. Hence, this device can be applied in many medical fields by downsizing it.

  5. Design and kinematics of a tube-shaped multidirectional bending robotic device using slackened SMA wires for transurethral ureterolithotripsy

    Wenrui Liu, Noriko Tsuruoka, Yoshikatsu Tanahashi, Yoichi Haga

    INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY　18　(1)　29-43　2023/01

    Publisher: SPRINGER HEIDELBERG

    DOI： 10.1007/s11548-022-02756-3 　

    ISSN：1861-6410

    eISSN：1861-6429

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    Purpose The complex and elaborate structure of the urinary system presents surgeons with difficulty in using a ureteroscope with a fixed optical fiber to reach the targeted calculus. To address this challenge, a robotic device is required to control the direction of laser irradiation position independently in ureteroscopes. Method A continuum robotic device was designed and fabricated. The device is constructed with three slackened shape memory alloy (SMA) wires to control the laser irradiation position of the optical fiber combined with the view of the camera on the tip of the ureteroscope. Kinematics analysis and experimental evaluation reveal the capability of the device. Results The structure of the device is the same as a single-joint continuum robot. This device is unique because of the tiny diameter of 1.1 mm which can be used inside the ureteroscope through a o1.2 mm inner channel into the kidney for transurethral ureterolithotripsy. Kinematic analysis revealed the relationship among space coordinates, angles of bending, and direction and SMA wires length. The maximum bending angle was around 25 degrees when the current value was 350 mA on a single SMA wire. The device could achieve multi-directional bending by allocating the values of current on SMA wires, separately. Conclusion This device offers a major advancement in small size and dexterity in medical robotics. Combined with a proper control system, this device could simplify the operation and improve the efficiency of the transurethral ureterolithotripsy.

  6. Micro-Robotic Medical Tools Employing SMA Actuators for Use in the Human Body

    Haga Yoichi, Mineta Takashi, Matsunaga Tadao, Tsuruoka Noriko

    Journal of Robotics and Mechatronics　34　(6)　1233-1244　2022/12/20

    Publisher: Fuji Technology Press Ltd.

    DOI： 10.20965/jrm.2022.p1233 　

    ISSN：0915-3942

    eISSN：1883-8049

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    Several micro-robotic medical tools, including catheters, guide wires, and endoscopes, employing shape memory alloy (SMA) actuators have been proposed and developed for use in the human body. This paper describes the basic principle of SMAs and the characteristics of several mechanisms, such as unidirectional bending, multi-directional bending, torsional movement, extension, and stiffness control. Moreover, some medical applications, such as insertion assistance and endoscopic and laser positioning, are described.

  7. Tube-shaped Neural Probe with Electrodes Placed Around the Optical Stimulation Area or the Endoscope Observation Area

    Naoto Ikeda, Wenguang Lu, Noriko Tsuruoka, Hajime Mushiake, Makoto Osanai, Tomokazu Oshiro, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　142　(4)　48-55　2022/04/01

    Publisher: Institute of Electrical Engineers of Japan (IEE Japan)

    DOI： 10.1541/ieejsmas.142.48 　

    ISSN：1341-8939

    eISSN：1347-5525

  8. Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4. International-journal

    Michio Murakoshi, Yuhi Koike, Shin Koyama, Shinichi Usami, Kazusaku Kamiya, Katsuhisa Ikeda, Yoichi Haga, Kohei Tsumoto, Hiroyuki Nakamura, Noriyasu Hirasawa, Kenji Ishihara, Hiroshi Wada

    Auris, nasus, larynx　2022/03/16

    DOI： 10.1016/j.anl.2022.03.009 　

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    OBJECTIVE: Pendrin is a transmembrane protein encoded by the SLC26A4 gene that functions in maintaining ion concentrations in the endolymph of the inner ear, most likely by acting as a chloride/bicarbonate transporter. Variants in the SLC26A4 gene are responsible for sensorineural hearing loss. Although pendrin localizes to the plasma membrane, we previously identified that 8 missense allele products of SLC26A4 were retained in the intracellular region and lost their anion exchange function. We also found that 10 mM salicylate induced the translocation of 4 out of 8 allele products from the intracellular region to the plasma membrane and restored their anion exchanger activity. However, since 10 mM salicylate exhibits cytotoxicity, the use of chemical compounds with less cell toxicity is needed. In the present study, therefore, salicylate derivatives were used as the chemical compounds and their effects on the p.H723R allele products of SLC26A4 were investigated. METHODS: HEK293 cells were transfected with the cDNA of p.H723R. Cell proliferation, viability and toxicity assays were performed to investigate the response and health of cells in culture after treatment with four types of salicylate derivatives, i.e., 2-hydroxybenzyl alcohol, 2,3-dihydroxybenzoic acid, 2'-hydroxyacetophenone and methyl salicylate. The effects of these salicylate derivatives on the localization of the p.H723R were investigated by immunofluorescence microscopy. RESULTS: The application of 10 mM salicylate showed an increase in cell toxicity and decrease in cell viability, leading to a significant decrease in cell proliferation. In contrast, the application of 1 mM salicylate derivatives did not show any significant increase in cell toxicity and decrease in cell viability, corresponding to a logarithmic increase in cell concentration with an increase in culture time. Immunofluorescence experiments showed that the p.H723R retained in the endoplasmic reticulum (ER). Among the salicylate derivatives applied, 2-hydroxybenzyl alcohol induced the translocation of p.H723R from the ER to the plasma membrane 3 h after its application. CONCLUSION: The results obtained showed that 2-hydroxybenzyl alcohol restored the localization of the p.H723R allele products of SLC26A4 from the ER to the plasma membrane at a concentration of 1 mM by 3 h after its administration with less cytotoxicity than 10 mM salicylate.

  9. Device to Collect Skin Cells Using Ultrasound Irradiation and Aspiration

    Yang Ye, Tatsuya Uechi, Noriko Tsuruoka, Makoto Akashi, Yoichi Haga

    SENSORS AND MATERIALS　34　(9)　3383-3396　2022

    Publisher: MYU, SCIENTIFIC PUBLISHING DIVISION

    DOI： 10.18494/SAM3983 　

    ISSN：0914-4935

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    Dynamic cell activity can be examined by collecting and analyzing cells every' few hours during the day. However, current techniques to extract and analyze skin cells are deemed ineffective and/or invasive. Thus, in this study, we designed and fabricated a device that collects skin cells using ultrasound irradiation. An ultrasonic horn amplifies a Langevin transducer, which then generates ultrasound and transmits it to a fine needle. Ultrasound is irradiated from the needle to the body surface, and ultrasonic oscillation and cavitation cut or weaken intercellular binding. We successfully aspirated 30 cells from pig skin using our minimally invasive device.

  10. Cell Collection Device from Mucosal Tissue Using Cavitation Caused by Ultrasound Irradiation

    Yang Ye, Uechi Tatsuya, Tsuruoka Noriko, Akashi Makoto, Haga Yoichi

    Journal of Japan Society of Computer Aided Surgery　24　(4)　217-225　2022

    Publisher: The Japan Society of Computer Aided Surgery

    DOI： 10.5759/jscas.24.217 　

    ISSN：1344-9486

    eISSN：1884-5770

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    Examination of human intracellular processes is an exponentially exploding frontier in medical science that is currently studied in static cell populations at specific time points. Acquiring detailed information about dynamic changes in RNA transcription and protein expression in living cells has the potential to impact patient and animal care profoundly. We fabricated an ultrasonic device for collecting cells from the mucosal tissue of living organisms. Detailed cell activity could be ascertained by collecting and analyzing cells intermittently throughout the day using this device. A Langevin-type oscillator generated ultrasonic sound waves that are propagated to the mucosal tissue via a metal rod. The bonds between the cells are weakened or broken by cavitation, and the cells are collected by circulating physiological saline. During the initial testing of this device, we collected over 1000 cells repeatedly from the same site of excised porcine esophageal mucosa with a sampling time of 1 minute and an ultrasonic intensity slightly exceeding the cavitation threshold. This confirms that this device can be used to collect cells multiple times per day. It is expected that live cells can be collected for analysis during daily life. Cells can also be collected using this minimally invasive device from the mucosa of the digestive tract by attaching this device to the tip of an endoscopic tool. Cells can be collected from various organs during surgery for the analysis of pathological conditions and for analysis that could help delineate more precise surgical procedures.

  11. Cerebrovascular Model Equipped with Microsensors

    Yoichi Haga, Hiroshi Yoshida, Tadao Matsunaga, Yasutomo Shimizu, Makoto Ohta, Masaaki Shojima, Taisuke Masuda, Kaihong Yu, Tupin Simon, Chenming Dai, Fumihito Arai, Kanako Harada

    IEEJ Transactions on Sensors and Micromachines　140　(12)　354-362　2020/12/01

    Publisher: Institute of Electrical Engineers of Japan ({IEE} Japan)

    DOI： 10.1541/ieejsmas.140.354 　

    ISSN：1347-5525

  12. Viscosity measurement of Xanthan-Poly(vinyl alcohol) mixture and its effect on the mechanical properties of the hydrogel for 3D modeling. International-journal Peer-reviewed

    Yasutomo Shimizu, Tadao Tanabe, Hiroshi Yoshida, Motohiro Kasuya, Tadao Matsunaga, Yoichi Haga, Kazue Kurihara, Makoto Ohta

    Scientific reports　8　(1)　16538-16538　2018/11/08

    DOI： 10.1038/s41598-018-34986-4 　

    ISSN：2045-2322

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    Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes require higher pressures than the upper pressure limit of the dispensers for pouring in high viscosity materials; the material viscosity should therefore be lower. Moreover, the mechanical properties of the biomodels should be reproduced. This study proposes a PVA solution through the addition of xanthan gum (XG) for 3D modeling, which lowers liquid viscosity while maintaining the mechanical properties of biomodels. XG is known to facilitate the achievement of non-Newtonian fluidity; however, the effects of XG on a PVA solution and PVA hydrogel (PVA-H) are not confirmed. The viscosity measurement using 15 wt% PVA with XG solution (PVA/XG) shows that it will provide easier pouring than 17 wt% PVA solution. The tensile test using the PVA-H of PVA(15 wt%)/XG(0.2 wt%) reveals that the gel is comparable in Young's modulus to 17 wt% PVA-H. X-ray diffraction shows the crystalline structures of the PVA/XG gel and PVA-H are identical. Thus, this PVA/XG would be useful for fabricating biomodels using injection molding techniques.

  13. Fabrication and Packaging of CMUT Using Low Temperature Co-Fired Ceramic Peer-reviewed

    Yildiz Fikret, Matsunaga Tadao, Haga Yoichi

    MICROMACHINES　9　(11)　2018/11

    DOI： 10.3390/mi9110553 　

    ISSN：2072-666X

  14. A new manometry device for evaluating the sphincter of Oddi using a fiber-optic pressure sensor. Peer-reviewed

    Hanzawa T, Matsunaga T, Koike T, Kanno A, Masamune A, Iijima K, Shimosegawa T, Haga Y

    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy　27　(4)　226-232　2018/08

    DOI： 10.1080/13645706.2017.1412701 　

    ISSN：1364-5706

  15. Oesophageal mucosal blood flow changes after thoracic endovascular stent graft implantation using a novel sensor probe Peer-reviewed

    Shintaro Katahira, Shunsuke Kawamoto, Naoki Masaki, Yukihiro Hayatsu, Tadao Matsunaga, Yoichi Haga, Yoshikatsu Saiki

    Interactive Cardiovascular and Thoracic Surgery　26　(3)　487-493　2018/03/01

    Publisher: Oxford University Press

    DOI： 10.1093/icvts/ivx351 　

    ISSN：1569-9285 1569-9293

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    OBJECTIVES: Secondary aorto-oesophageal fistula is a rare, lethal complication occurring after thoracic endovascular aneurysmal repair. The cause of secondary aorto-oesophageal fistula is unknown, but a reduction in local oesophageal mucosal blood flow (OMBF) may be a basis for such a devastating sequela. Our study aims to develop a novel blood flow sensor probe to detect changes in OMBF after thoracic stent graft implantation in an experimental swine model. METHODS: A novel laser Doppler flowmetry sensor probe incorporating an optical fibre sensor within a nasogastric tube was developed using microelectromechanical system technology. OMBF was measured at various levels using this sensor probe, to test its feasibility before and after thoracic endovascular stent graft implantation covering Th4-Th8 vertebral levels in 6 swine. RESULTS: In the middle oesophagus (Th5-Th7), where the aorta was covered with a stent graft, the measured OMBFs were significantly decreased after thoracic endovascular stent graft implantation than those of baseline (8.6 ± 2.7 vs 18.4 ± 7.9 ml/min/100 g, P &lt 0.0001), followed by a plateau period for at least 2 h after stent grafting (8.7 ± 3.3 ml/min/100 g, P &lt 0.0001 vs baseline). OMBFs in the upper (Th1-Th3) and lower (Th9-Th11) oesophagus, where the aorta was not covered with a stent graft, were unaffected by thoracic endovascular stent grafting. CONCLUSIONS: The novel laser Doppler flowmetry sensor probe was useful to monitor precise changes of OMBF in a swine model, demonstrating a significant reduction in OMBF after thoracic endovascular stent graft implantation.

  16. Noninvasive aspiration detection using through-transmission ultrasound. Peer-reviewed

    Yosuke Hara, Yukio Katori, Shigeaki Okumura, Hirofumi Taki, Hiroki Umeda, Tatsuya Uechi, Fumihiko Kawamura, Yoichi Haga, Ryoichi Nagatomi, Shin-Ichi Izumi

    20th IEEE International Conference on e-Health Networking, Applications and Services, Healthcom 2018, Ostrava, Czech Republic, September 17-20, 2018　1-5　2018

    Publisher: IEEE

    DOI： 10.1109/HealthCom.2018.8531081 　

  17. Forward-looking OCT Probe Using Single-fiber Scanning for Transbronchial Puncturing Cytodiagnosis Peer-reviewed

    Li Xuan, Matsunaga Tadao, Suda Yuji, Sawai Takashi, Haga Yoichi

    ADVANCED BIOMEDICAL ENGINEERING　6　48-52　2017

    DOI： 10.14326/abe.6.48 　

    ISSN：2187-5219

  18. Development of a blood vessel model with ultrasound sensors to quantify intravascular treatment skills. Peer-reviewed

    Hiroshi Yoshida, Tadao Matsunaga, Yasutomo Shimizu, Masaaki Shojima, Kaihong Yu, Makoto Ohta, Noriko Tsuruoka, Yoichi Haga

    International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017, Nagoya, Japan, December 3-6, 2017　1-4　2017

    Publisher: IEEE

    DOI： 10.1109/MHS.2017.8305199 　

  19. Local internal pressure measurement system of cerebral aneurysm model using ultra-miniature fiber-optic pressure sensor. Peer-reviewed

    Tadao Matsunaga, Akira Ito, Soyoka Osaki, Yasutomo Shimizu, Masaaki Shojima, Hiroshi Yoshida, Noriko Tsuruoka,Array, Makoto Ohta, Yoichi Haga

    International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017, Nagoya, Japan, December 3-6, 2017　1-3　2017

    Publisher: IEEE

    DOI： 10.1109/MHS.2017.8305197 　

  20. Ultrasound sensors installed in blood vessel model for intravascular surgery procedures. Peer-reviewed

    Hiroshi Yoshida, Noriko Tsuruoka, Yasutomo Shimizu, Kaihong Yu, Makoto Ohta, Masaaki Shojima, Tadao Matsunaga, Yoichi Haga

    IEEE International Conference on Cyborg and Bionic Systems, CBS 2017, Beijing, China, October 17-19, 2017　289-292　2017

    Publisher: IEEE

    DOI： 10.1109/CBS.2017.8266117 　

  21. Multipoint pressure measurement in blood vessel model for evaluation of intravascular treatment of cerebral aneurysm using fiber-optic pressure sensors. Peer-reviewed

    Tadao Matsunaga, Yoichi Haga, Soyoka Osaki, Yasutomo Shimizu,Array, Makoto Ohta, Masaaki Shojima, Hiroshi Yoshida, Noriko Tsuruoka

    IEEE International Conference on Cyborg and Bionic Systems, CBS 2017, Beijing, China, October 17-19, 2017　136-139　2017

    Publisher: IEEE

    DOI： 10.1109/CBS.2017.8266083 　

  22. Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain Peer-reviewed

    Yui Mano, Ryuta Saito, Yoichi Haga, Tadao Matsunaga, Rong Zhang, Masashi Chonan, Shinya Haryu, Takuhiro Shoji, Aya Sato, Yukihiko Sonoda, Noriko Tsuruoka, Keisuke Nishiyachi, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Teiji Tominaga

    JOURNAL OF NEUROSURGERY　124　(5)　1490-1500　2016/05

    Publisher: AMER ASSOC NEUROLOGICAL SURGEONS

    DOI： 10.3171/2015.3.JNS142152 　

    ISSN：0022-3085

    eISSN：1933-0693

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    OBJECTIVE Convection-enhanced delivery (CED) is an effective drug delivery method that delivers high concentrations of drugs directly into the targeted lesion beyond the blood-brain barrier. However, the drug distribution attained using CED has not satisfactorily covered the entire targeted lesion in tumors such as glioma. Recently, the efficacy of ultrasound assistance was reported for various drug delivery applications. The authors developed a new ultrasound facilitated drug delivery (UFD) system that enables the application of ultrasound at the infusion site. The purpose of this study was to demonstrate the efficacy of the UFD system and to examine effective ultrasound profiles. METHODS The authors fabricated a steel bar based device that generates ultrasound and enables infusion of the aqueous drug from one end of the bar. The volume of distribution (Vd) after infusion of 10 mu l of 2% Evans blue dye (EBD) into rodent brain was tested with different frequencies and applied voltages: 252 kHz/30 V; 252 kHz/60 V; 524 kHz/13 V; 524 kHz/30 V; and 524 kHz/60 V. In addition, infusion of 5 mM gadopentetate dimeglumine (Gd-DTPA) was tested with 260 kHz/60 V, the distribution of which was evaluated using a 7-T MRI unit. In a nonhuman primate (Macaca fascicularis) study, 300 mu l of 1 mM Gd-DTPA/EBD was infused. The final distribution was evaluated using MRI. Two-sample comparisons were made by Student t-test, and 1-way ANOVA was used for multiple comparisons. Significance was set at p &lt; 0.05. RESULTS After infusion of 10 mu l of EBD into the rat brain using the UFD system, the Vds of EBD in the UFD groups were significantly larger than those of the control group. When a frequency of 252 kHz was applied, the Vd of the group in which 60 V was applied was significantly larger than that of the group in which 30 V was used. When a frequency of 524 kHz was applied, the Vd tended to increase with application of a higher voltage; however, the differences were not significant (1-way ANOVA). The Vd of Gd-DTPA was also significantly larger in the UFD group than in the control group (p &lt; 0.05, Student t-test). The volume of Gd-DTPA in the nonhuman primate used in this study was 1209.8 +/- 193.6 mm(3). This volume was much larger than that achieved by conventional CED (568.6 +/- 141.0 mm(3)). CONCLUSIONS The UFD system facilitated the distribution of EBD and Gd-DTPA more effectively than conventional CED. Lower frequency and higher applied voltage using resonance frequencies might be more effective to enlarge the Vd. The UFD system may provide a new treatment approach for CNS disorders.

  23. Lactate and glucose measurement in subepidermal tissue using minimally invasive microperfusion needle Peer-reviewed

    Noriko Tsuruoka, Kenji Ishii, Tadao Matsunaga, Ryoichi Nagatomi, Yoichi Haga

    BIOMEDICAL MICRODEVICES　18　(1)　19　2016/02

    Publisher: SPRINGER

    DOI： 10.1007/s10544-016-0049-z 　

    ISSN：1387-2176

    eISSN：1572-8781

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    Knowing the concentrations of biological substances can help ascertain physiological and pathological states. In the present study, a minimally invasive microperfusion needle was developed for measuring the concentrations of biological substances in subepidermal tissue. The microperfusion needle has a flow channel with a perforated membrane through which biological substances from subepidermal tissue are extracted. Since this device uses a thin steel acupuncture needle as the base substrate, it has sufficient rigidity for insertion through the skin. The efficacy of the needle was examined by measuring lactate and glucose concentrations in mice. Lactate was injected intraperitoneally, and changes in lactate concentrations in subepidermal tissue over time were measured using the device. Lactate concentrations of blood were also measured as a reference. Lactate was successfully collected using the microperfusion needle, and the lactate concentration of perfused saline was significantly correlated with blood lactate concentration. Glucose solution was administered orally, and the glucose concentration of perfused saline was also correlated with blood glucose concentration. The newly developed microperfusion needle can be used for minimally invasive monitoring of the concentrations of biological substances.

  24. Micro sensors and actuators for minimally invasive medical devices and bionic humanoid. Peer-reviewed

    Tadao Matsunaga, Yoichi Haga

    International Symposium on Micro-NanoMechatronics and Human Science, MHS 2016, Nagoya, Japan, November 28-30, 2016　1-2　2016

    Publisher: IEEE

    DOI： 10.1109/MHS.2016.7824216 　

  25. Development of forward viewing optical coherence tomography probe using electromagnetic drive for bronchoscopey

    Li Xuan, Haga Yoichi, Matsunaga Tadao

    Transactions of Japanese Society for Medical and Biological Engineering　53　S238_01-S238_01　2015

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.53.S238_01 　

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    The purpose of this study is to develop a small (1.3 mm diameter) and high resolution (Lateral resolution: more than 60 &mu;m, Distance resolution: 12 &mu;m) optical coherence tomography probe for bronchoscopey. This probe consists of single optical fiber which is fixed a Ni tube and a micro lens (SELFOC lens) which is located in front of the optical fiber, metal saddle-shaped coils which are fabricated by photofabrication and two solenoid coils which are fabricated by coiling machine. The solenoid coils are located in frontside and backside of the saddle-shaped coil. When an alternating current is applied to the driving coils, the Ni tube was vibrated by electromagnetic force one dimensionally. The optical fiber amplitude is assisted by magnetic force of the solenoid shaped assist coils. To satisfy required view angle (45 degrees), the optical fiber vibration amplitude needs 236 &mu;m/p-p. The evaluated fiber vibration amplitude of the fabricated probe was 56 &mu;m/p-p. To satisfy the required vibration amplitude, adjusting positions of assist coils will be effective for enlarge the optical fiber vibration.

  26. Real-time monitoring of spinal cord blood flow with a novel sensor mounted on a cerebrospinal fluid drainage catheter in an animal model Peer-reviewed

    Yukihiro Hayatsu, Shunsuke Kawamoto, Tadao Matsunaga, Yoichi Haga, Yoshikatsu Saiki

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY　148　(4)　1726-1731　2014/10

    Publisher: MOSBY-ELSEVIER

    DOI： 10.1016/j.jtcvs.2014.04.011 　

    ISSN：0022-5223

    eISSN：1097-685X

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    Objective: The aim of our study was to develop a novel monitoring system for spinal cord blood flow (SCBF) to test the efficacy of the SCBF sensor in an animal model. Methods: The sensor system consisted of 2 optical fibers, a pedestal for fiber fixation, and a mirror for the laser reflection and was incorporated into a cerebrospinal fluid drainage catheter. In vivo studies were performed in a swine model (n = 10) to measure SCBF during spinal cord ischemia induced by clamping the descending thoracic aorta and supra-aortic neck vessels, when necessary. A temporary low cardiac output model was also created by inflow clamping of the inferior vena cava to analyze the quantitative changes in SCBF during this maneuver. Results: The developed SCBF monitoring catheter placed intrathecally could detect SCBF in all the swine. The SCBF after aortic crossclamping at the fourth intercostal level exhibited diverse changes reproducibly among the swine, with a &gt;25% reduction in SCBF in 5 pigs, an increase in 3, and no significant changes in 2. Consistent reductions were recorded during inferior vena cava occlusion. The mean SCBF decreased by 32% after inferior vena cava occlusion when the cardiac output had decreased by 27%. Conclusions: We have developed a novel SCBF sensor that could detect real-time changes in spinal cord perfusion in a swine model. The device holds promise to detect imminent ischemia or ensure acceptable blood perfusion in the spinal cord and could further enhance our understanding of spinal cord circulation.

  27. 液圧アクチュエータを用いた内視鏡用径可変フードの開発 Peer-reviewed

    松尾美幸, 須田信一郎, 松永忠雄, 芳賀洋一

    ロボティクス・メカトロニクス講演会2014 in Toyama (ROBOMECH2014 TOYAMA)　2014

  28. Brief Effect of Acupoint Stimulation Using Focused Ultrasound Peer-reviewed

    Noriko Tsuruoka, Masashi Watanabe, Shin Takayama, Takashi Seki, Tadao Matsunaga, Yoichi Haga

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE　19　(5)　416-419　2013/05

    Publisher: MARY ANN LIEBERT INC

    DOI： 10.1089/acm.2012.0217 　

    ISSN：1075-5535

    eISSN：1557-7708

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    Background: Acupuncture is used worldwide in medical treatment. However, needle insertion damages the skin and patients sometimes feel pain. To avoid such drawbacks, an acupoint stimulation device using focused ultrasound has been developed. Ultrasound stimulation does not damage the skin like acupuncture does because ultrasound can deliver vibration energy to soft tissues noninvasively. Objectives: The aim of this study was to clarify the effect of acupoint stimulation using focused ultrasound. Subjects: Fifty (50) healthy volunteers (40 males and 10 females) were included in this experiment. Design: Subjects were randomly assigned to two groups. LR-3 was stimulated bilaterally for 36 seconds by focused ultrasound and conventional acupuncture. Brachial artery blood flow volume was monitored by an ultrasound with an echo-tracking system. The hemodynamic parameters were measured before, during, and 30, 60, 180 seconds after stimulation. Results: During stimulation, the blood flow volume of the acupuncture stimulation group decreased significantly (p &lt; 0.05) compared with resting value, but that of the focused ultrasound stimulation group did not decrease. Blood flow volume of both groups increased gradually and showed significant increase at 180 seconds after stimulation (p &lt; 0.05). Conclusions: Blood flow volume was increased significantly by both focused ultrasound stimulation and conventional acupuncture. Although a significant decrease of blood flow volume during acupuncture stimulation was observed, no such decrease was observed during ultrasound stimulation. Findings of the present study show that noninvasive stimulation of acupoints by focused ultrasound is as effective as conventional acupuncture in blood flow volume of the brachial artery.

  29. Brief Effect of Acupoint Stimulation Using Focused Ultrasound Peer-reviewed

    Noriko Tsuruoka, Masashi Watanabe, Shin Takayama, Takashi Seki, Tadao Matsunaga, Yoichi Haga

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE　19　(5)　416-419　2013/05

    Publisher: MARY ANN LIEBERT INC

    DOI： 10.1089/acm.2012.0217 　

    ISSN：1075-5535

    eISSN：1557-7708

    More details Close

    Background: Acupuncture is used worldwide in medical treatment. However, needle insertion damages the skin and patients sometimes feel pain. To avoid such drawbacks, an acupoint stimulation device using focused ultrasound has been developed. Ultrasound stimulation does not damage the skin like acupuncture does because ultrasound can deliver vibration energy to soft tissues noninvasively. Objectives: The aim of this study was to clarify the effect of acupoint stimulation using focused ultrasound. Subjects: Fifty (50) healthy volunteers (40 males and 10 females) were included in this experiment. Design: Subjects were randomly assigned to two groups. LR-3 was stimulated bilaterally for 36 seconds by focused ultrasound and conventional acupuncture. Brachial artery blood flow volume was monitored by an ultrasound with an echo-tracking system. The hemodynamic parameters were measured before, during, and 30, 60, 180 seconds after stimulation. Results: During stimulation, the blood flow volume of the acupuncture stimulation group decreased significantly (p &lt; 0.05) compared with resting value, but that of the focused ultrasound stimulation group did not decrease. Blood flow volume of both groups increased gradually and showed significant increase at 180 seconds after stimulation (p &lt; 0.05). Conclusions: Blood flow volume was increased significantly by both focused ultrasound stimulation and conventional acupuncture. Although a significant decrease of blood flow volume during acupuncture stimulation was observed, no such decrease was observed during ultrasound stimulation. Findings of the present study show that noninvasive stimulation of acupoints by focused ultrasound is as effective as conventional acupuncture in blood flow volume of the brachial artery.

  30. Tactile display using shape memory alloy micro-coil actuator and magnetic latch mechanism Peer-reviewed

    T. Matsunaga, K. Totsu, M. Esashi, Y. Haga

    Displays　34　(2)　89-94　2013

    DOI： 10.1016/j.displa.2013.03.001 　

    ISSN：0141-9382

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    A two-dimensional tactile display for visually impaired people was fabricated and successfully operated. Character and graphic information is dynamically displayed by an array of pins in up and down positions. The contraction of shape memory alloy (SMA) micro-coil actuators moves the pins up and down when the SMA actuator is heated by an electrical current. A tube fabricated from magnetic material is attached to each pin and a permanent magnet accurately positions the pins in an up or down state without any feedback control. This latch mechanism overcomes problems of heat storage and electrical consumption of the SMA actuator because the current is supplied only when the pins move. The tactile display has a 100 (10 × 10) pins array. The tactile information is displayed sequentially every 0.3 s and the tactile pins are latched at 0.1 N by magnetic force. The pins are arranged at a pin interval of 2.5 mm and move 2 mm up and down. Furthermore, in order to offer tactile graphic information, the interval between pins is narrow. A module for the tactile display with pin intervals of 1.27 mm has also been developed. © 2013 Elsevier Ltd.All rights reserved. © 2013 Elsevier B.V.All rights reserved.

  31. 陽極接合可能なセラミック貫通配線基板を用いた静電駆動型超音波トランスデューサ Peer-reviewed

    広島美咲, 松永忠雄, 峯田 貴, 芳賀 洋一

    第30回「センサ・マイクロマシンと応用システム」シンポジウム論文集　2013

  32. SMA ワイヤを用いた低侵襲医療用能動屈曲機構 Peer-reviewed

    小林拓生, 松永忠雄, 芳賀 洋一

    第30回「センサ・マイクロマシンと応用システム」シンポジウム論文集　2013

  33. Micro hydraulic bending actuator for minimally invasive medical device Peer-reviewed

    Miyuki Matsuo, Kunihiro Abe, Shinichiro Suda, Tadao Matsunaga, Yoichi Haga

    2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013　1440-1443　2013

    DOI： 10.1109/Transducers.2013.6627050 　

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    Micro hydraulic actuators have been fabricated to improve the operability of minimally invasive medical instruments, such as guidewires, catheters, and endoscopes. The actuators consist of a metal spring coil, evaporated parylene membrane, and a metal wire. Since parylene is used as the membrane, the actuator can be made with a diameter smaller than 1 mm and several actuators can be batch fabricated. As shown in Fig.1, the actuator elongates except for the side that is restricted by a metal wire when water is injected, allowing the actuator to bend. Since the actuators use water to achieve the bending motion and consist of biocompatible materials, they are safe in the human body. © 2013 IEEE.

  34. Development and evaluation of tube-shaped neural probe with working channel Peer-reviewed

    Shunsuke Tamaki, Tadao Matsunaga, Toshinobu Kuki, Yoshihito Furusawa, Hajime Musiake, Yoichi Haga

    2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013　864-867　2013

    DOI： 10.1109/Transducers.2013.6626904 　

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    For brain analysis, a novel tube-shaped flexible neural probe characterize by its flexibility and stiffness with metal needle inserted into tube was fabricated and demonstrated. This probe consists of an ultra-thin polyimide tube with on outer diameter of 360μm and photofabricated recording electrodes using non-planar photofabrication technique. The probe was inserted into a rat's brain through the dura mater and successfully measured with optical stimulation. © 2013 IEEE.

  35. Measurement of subcutaneous biological substances using thin metal needle with micro flow channel Peer-reviewed

    N. Tsuruoka, K. Ishii, T. Matsunaga, R. Nagatomi, Y. Haga

    Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　4478-4481　2013

    Publisher: IEEE

    DOI： 10.1109/EMBC.2013.6610541 　

    ISSN：1557-170X

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    Concentrations of biological substances are useful as indicators of physiological and pathological states. In order to monitor biological substances in daily life, we developed a minimally invasive needle type device with which biological substances are extracted through a microperfusion system inserted under the skin. The perfusion needle has a flow channel with perforated membrane through which biological substances from subepidermal tissue are extracted. The efficacy of the device was examined by measuring lactate concentration of exercising mice. Lactate was successfully collected from the back skin of the mice running on a treadmill using a fabricated microperfusion needle. Lactate concentration of perfused solution correlated with blood lactate concentration. © 2013 IEEE.

  36. 多機能化を目指した折れ曲がり変形型内視鏡の開発 Peer-reviewed

    須田信一郎, 松永忠雄, 芳賀洋一

    日本コンピュータ外科学会誌　14　(4)　447-454　2012

    Publisher: The Japan Society of Computer Aided Surgery

    DOI： 10.5759/jscas.14.447 　

    ISSN：1344-9486

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    The outer diameter of a rigid and flexible endoscope is limited because of the small incision for insertion of the endoscope, and thus it is difficult to incorporate several functions. In this research, a multifunctional bending transformative endoscope with a small diameter for insertion was developed. The tip of the endoscope is divided into three sections, and it can be transformed by manipulating wires from outside the body. Models of this bending type endoscope, which has two CCD cameras for 3D vision and rear view, were fabricated. Insertion of a forceps through its working channel was also demonstrated.

  37. Development of Minimally Invasive Microdialysis Needle for Continuous Monitoring of Biological Substances Peer-reviewed

    N. Tsuruoka, K. Ishii, T. Matsunaga, R. Nagatomi, Y. Haga

    Technical Digest of the 25th IEEE International Conference on Micro ElectroMechanical Systems (MEMS 2012)　941-944　2012

    DOI： 10.1109/MEMSYS.2012.6170341 　

  38. 使い捨て化と細径化を目指した形状記憶合金を用いた能動屈曲電子内視鏡の開発 Peer-reviewed

    牧志 渉, 池田雅春, 江刺正喜, 松永忠雄, 芳賀洋一

    電気学会論文誌E　131　(3)　102-110　2011

    DOI： 10.1541/ieejsmas.131.102 　

  39. Bending Transformative Endoscope Peer-reviewed

    S. Suda, T. Matsunaga, Y. Haga

    6th International Conference on Microtechnologies in Medicine and Biology (MMB 2011),　2011

  40. Spinal Ischemia Monitoring Catheter Using Miniature Ultrasonic Sensor Peer-reviewed

    M. Sato, Y. Saiki, K. Nishiyachi, T. Matsunaga, H. Nagai, M. Esashi, Y. Haga

    6th International Conference on Microtechnologies in Medicine and Biology (MMB 2011)　2011

  41. Salicylate restores transport function and anion exchanger activity of missense pendrin mutations Peer-reviewed

    Kenji Ishihara, Shuhei Okuyama, Shun Kumano, Koji Iida, Hiroshi Hamana, Michio Murakoshi, Toshimitsu Kobayashi, Shinichi Usami, Katsuhisa Ikeda, Yoichi Haga, Kohei Tsumoto, Hiroyuki Nakamura, Noriyasu Hirasawa, Hiroshi Wada

    HEARING RESEARCH　270　(1-2)　110-118　2010/12

    Publisher: ELSEVIER SCIENCE BV

    DOI： 10.1016/j.heares.2010.08.015 　

    ISSN：0378-5955

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    The SLC26A4 gene encodes the transmembrane protein pendrin, which is involved in the homeostasis of the ion concentration of the endolymph of the inner ear, most likely by acting as a chloride/bicarbonate transporter. Mutations in the SLC26A4 gene cause sensorineuronal hearing loss. However, the mechanisms responsible for such loss have remained unknown. Therefore, in this study, we focused on the function of ten missense pendrin mutations (p.P123S (Pendred syndrome), p.M147V (NSEVA), p.K369E (NSEVA), p.A372V (Pendred syndrome/NSEVA), p.N392Y (Pendred syndrome), p.C565Y (NSEVA), p.S657N (NSEVA), p.S666F (NSEVA), p.T721M (NSEVA) and p.H723R (Pendred syndrome/NSEVA)) reported in Japanese patients, and analyzed their cellular localization and anion exchanger activity using HEK293 cells transfected with each mutant gene. Immunofluorescent staining of the cellular localization of the pendrin mutants revealed that p.K369E and p.C565Y, as well as wild-type pendrin, were transported to the plasma membrane, while 8 other mutants were retained in the cytoplasm. Furthermore, we analyzed whether salicylate, as a pharmacological chaperone, restores normal plasma membrane localization of 8 pendrin mutants retained in the cytoplasm to the plasma membrane. Incubation with 10 mM of salicylate of the cells transfected with the mutants induced the transport of 4 pendrin mutants (p.P123S, p.M147V, p.S657Y and p.H723R) from the cytoplasm to the plasma membrane and restored the anion exchanger activity. These findings suggest that salicylate might contribute to development of a new method of medical treatment for sensorineuronal hearing loss caused by the mutation of the deafness-related proteins, including pendrin. (C) 2010 Elsevier B.V. All rights reserved.

  42. 医療用MEMSデバイスと実装技術 Peer-reviewed

    芳賀洋一, 松永忠雄, 江刺正喜

    第26回「センサ・マイクロマシンと応用システム」シンポジウム論文集　662-668　2010/10

  43. blast-induced traumatic brain injury (bTBI): multidisciplinary teamによる病態解明から機器開発まで Peer-reviewed

    中川敦寛, 荒船龍彦, 大谷清伸, 山本裕朗, 松永忠雄, 鷲尾利克, 塚本 哲, 中野 徹, 仲井正昭, 合田圭介, 小川欣一, 孫 明宇, 隈部俊宏, 芳賀洋一, B. Jalai, 牛田多加志, 高山和喜, 西野精治, 新家光雄, 佐久間一郎, 冨永悌二

    神経外傷　33　(2)　187-194　2010

  44. Acupoint Stimulation Device Using Focused Ultrasound Peer-reviewed

    N. Tsuruoka, M. Watanabe, T. Seki, T. Matsunaga, Y. Haga

    32nd Annual International IEEE EMBS Conference, Buenos Aires　2010

    DOI： 10.1109/IEMBS.2010.5626422 　

  45. Electromagnetically Driven Ulutra-miniature single Fiber Scanner for High-resolution Endoscopy Fabricated on Cylindrical Substrates Using MEMS Process Peer-reviewed

    T. Matsunaga, R. Hino, W. Makishi, M. Esashi, Y. Haga

    IEEE The 23rd International Micro Electro Mechanical Systems Conference (MEMS 2010)　2010

    DOI： 10.1109/MEMSYS.2010.5442377 　

  46. Acupoint Stimulation Device Using Focused Ultrasound Peer-reviewed

    N. Tsuruoka, M. Watanabe, T. Seki, T. Matsunaga, Y. Haga

    32nd Annual International IEEE EMBS Conference　2010

    DOI： 10.1109/IEMBS.2010.5626422 　

  47. 体内管腔撮像用多層コイル型MRI プローブの開発 Peer-reviewed

    市村想生, 全 威, 松永忠雄, 松岡雄一郎, 黒田 輝, 江刺正喜, 芳賀洋一

    第26回「センサ・マイクロマシンと応用システム」シンポジウム論文集　449-454　2009/10

  48. Small Diameter High Resolution Endoscope Using Electromagnetically Vibration of Single Fiber Peer-reviewed

    T. Matsunaga, R. Hino, W. Makishi, M. Esashi, Y. Haga

    IEEJ Trans. SM　129　(11)　399-404　2009

    DOI： 10.1541/ieejsmas.129.399 　

  49. 円筒面レーザプロセスを用いた低侵襲医療機器の開発 Peer-reviewed

    芳賀洋一, 六鎗雄太, 五島彰二, 松永忠雄, 江刺正喜

    電気学会論文誌E　128　(10)　2008

    DOI： 10.1541/ieejsmas.128.402 　

  50. カテーテル実装に適した血管内MRIプローブの開発 Peer-reviewed

    五島彰二, 松永忠雄, 松岡雄一郎, 黒田 輝, 江刺正喜, 芳賀洋一

    電気学会論文誌E　128　(10)　2008

    DOI： 10.1541/ieejsmas.128.389 　

  51. Forward-looking Intravascular Ultrasound Probe Using PMN-PT Single Crystal Peer-reviewed

    J.-J. Chen, R. Kashu, M. Esashi, Y. Haga

    the 4th Asia-Pacific Conference on Transducers and Micro-Nano Technology (APCOT2008)　2008

  52. 非平面微細加工技術を用いた細径能動屈曲電子内視鏡の作製 Peer-reviewed

    牧志 渉, 松永忠雄, 江刺正喜, 竜 新栄, 芳賀洋一

    電気学会E部門総合研究会（BMS-08）　2008

  53. 非平面フォトファブリケーションによるカテーテル搭載型血管内MRIプローブの開発 Peer-reviewed

    全 威, 五島彰二, 松永忠雄, 松岡雄一郎, 黒田 輝, 江刺正喜, 芳賀洋一

    電気学会E部門総合研究会（BMS-08）　2008

  54. 形状記憶合金を用いた能動屈曲電子内視鏡 Peer-reviewed

    牧志 渉, 松永忠雄, 江刺正喜, 芳賀洋一

    電気学会論文誌E　127　(2)　75-81　2007/02

    DOI： 10.1541/ieejsmas.127.75 　

  55. 小型収束超音波トランスデューサを用いた内視鏡的治療デバイス Peer-reviewed

    安居晃啓, 芳賀洋一, 陳, 俊傑, 伊関, 洋, 江刺正喜, 和田 仁

    電気学会論文誌E,　127　(2)　69-74　2007/02/01

    DOI： 10.1541/ieejsmas.127.69 　

  56. Minimally invasive diagnostics and treatment using micro/nano machining Peer-reviewed

    Yoichi Haga, Tadao Matsunaga, Wataru Makishi, Kentaro Totsu, Takashi Mineta, Masayoshi Esashi

    MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES　15　(4)　218-225　2006/08

    Publisher: TAYLOR & FRANCIS LTD

    DOI： 10.1080/13645700600836224 　

    ISSN：1364-5706

    eISSN：1365-2931

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    Several medical tools with various functions have been developed for minimally invasive diagnostics and treatment. Microfabrication techniques such as MEMS technology are useful for the realization of high-performance multifunctional minimally invasive medical tools with small sizes. An ultra-miniature pressure sensor and an intravascular ultrasonic forward-viewing imager have been developed as microsensors for use in the human body. Active bending catheters have been developed for steering catheter tips without using traction of wires from outside the body. An ultrasonic therapeutic tool for sonodynamic therapy and sonoporation, and a micro scanner for precise laser treatment have been developed as therapeutic tools for use in the human body. High-functionalized endoscopic tools and catheters will enable more precise and safe diagnostics and therapy, as well as novel diagnostics and treatment which have been impossible to date.

  57. Development of Medical and Welfare Microdevices Using Micro Technology Peer-reviewed

    Y. Haga, T. Matsunaga, W. Makishi, K. Totsu, M. Esashi

    the 13th International Display Workshops (IDW ’06)　2006

  58. 2D Laser Microscanner for Precise Laser Surgery and Small Size Head Mount Display Peer-reviewed

    W. Makishi, H. Akahori, T. Matsunaga, M. Esashi, Y. Haga

    the 13th International Display Workshops (IDW ’06)　2006

  59. Dynamic Tactile Display with Arrayed Pin for Blind Aid Using Micro Actuators Peer-reviewed

    T. Matsunaga, W. Makishi, Y. Haga

    the 13th International Display Workshops (IDW ’06)　1591-1594　2006

  60. Hermitically sealed ultra-miniature fiber-optic pressure sensor Peer-reviewed

    S. Nakamura, T. Matsunaga, K. Totsu, M. Esashi, Y. Haga

    IDW '06: PROCEEDINGS OF THE 13TH INTERNATIONAL DISPLAY WORKSHOPS, VOLS 1-3　1553-1556　2006

    Publisher: INST IMAGE INFORMATION & TELEVISION ENGINEERS

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    Ultra-Miniature fiber optic sensor of 125 mu m diameter has been developed by using MEMS fabrication techniques. The Fabry-Perot cavity is formed at the end of an optical fiber. The pressure induced deformation of the Fabry-Perot cavity diaphragm alters the cavity length. Fabricated sensor structures exhibited temperature dependency. To solve this problem, hermetic sealing using a thin-film solder bonding and Cr thin-film deposition on the sidewall of the sensor have been tried.

  61. Development of Medical Devices for Minimally Invasive Diagnostics and Treatment Using Micro/nano Technology Peer-reviewed

    Y. Haga

    The 12th International Micromachine / Nanotech Symposium　55-62　2006

  62. Fabrication Techniques for Multilayer Metalization and Patterning, and Surface Mounting of Components on Cylindrical Substrates for Tube-Shaped Micro-Tools Peer-reviewed

    S. Goto, T. Matsunaga, J. J. Chen, W. Makishi, M. Esashi, Y. Haga

    2006 International Conference on Microtechnologies in Medicine and Biology　217-220　2006

    DOI： 10.1109/MMB.2006.251532 　

  63. Small diameter ultrasound imager for intraluminal forward-looking inspection Peer-reviewed

    Jiun-Jie Chen, Masayoshi Esashi, Yoichi Haga

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　301-+　2006

    Publisher: WORLD SCIENTIFIC PUBL CO PTE LTD

    DOI： 10.1142/9781860948800_0032 　

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    An intraluminal forward-looking ultrasound probe of 3 min in diameter has been developed. We used the probe as transmitters and receivers to make ultrasound forward-looking and three-dimensional images, but many artifacts are observed because of strong directivity of the probe. For decreasing the directivity of the probe, a convex-shaped 1-3composite PZT transducer which is 0.7 min in diameter and 0.75 min curvature radius was fabricated, and low directivity feature was confirmed. A probe which has eight separated 1-3composite convex-shaped transducers is fabricated. The probe is 3 mm in diameter and a working channel is 0.5 mm in diameter. Acoustic pressure is measured using a hydrophone which is located 10 min in front of the probe. The emitting acoustic pressure of 0.85*10(5) Pascal is realized with the fabricated probe. When the probe is used as transmitters and receivers, image of an aluminum rod is constructed.

  64. Development of ultra-miniature fiber-optic pressure sensor Peer-reviewed

    Kentaro Totsu, Yoichi Haga, Tadao Matsunaga, Masayoshi Esashi

    FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　529-+　2006

    Publisher: WORLD SCIENTIFIC PUBL CO PTE LTD

    DOI： 10.1142/9781860948800_0059 　

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    A fiber-optic pressure sensor of 125 pm in diameter and detection system for medical use is described. A Fabry-Perot cavity with a diaphragm is formed at an optical fiber end. A deformation of the diaphragm induced by pressure varies the cavity length. White light interferometry is used to avoid error and noise caused by bending of the optical fiber and a fluctuation of the light source. The reflection light of the sensor cavity is detected by a portable detection system including a commercialized miniature high-speed spectrometer. A pressure change has been detected by using the developed sensor system. Animal experiments using a goat have been carried out and dynamic pressure changes in internal pressure of heart and aorta have been successfully monitored.

  65. 血管内低侵襲治療のための前方視超音波イメージャーの開発 Peer-reviewed

    陳 俊傑, 江刺正喜, 大城 理, 千原國宏, 芳賀洋一

    生体医工学　43　(4)　553-559　2005/12

    DOI： 10.11239/jsmbe.43.553 　

  66. 低侵襲医療のための光MEMS Peer-reviewed

    芳賀洋一, 赤堀寛昌, 戸津健太郎, 和田 仁 江刺正喜

    レーザー研究　33　(11)　754-760　2005/11

    DOI： 10.2184/lsj.33.754 　

  67. Medical and welfare applications of shape memory alloy microcoil actuators Peer-reviewed

    Y Haga, M Mizushima, T Matsunaga, M Esashi

    SMART MATERIALS AND STRUCTURES　14　(5)　S266-S272　2005/10

    Publisher: IOP PUBLISHING LTD

    DOI： 10.1088/0964-1726/14/5/015 　

    ISSN：0964-1726

    eISSN：1361-665X

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    We have successfully developed several mechanisms using Ti-Ni shape memory alloy (SMA) microcoil actuators, for example, a bending mechanism, an extension/contraction mechanism, a torsional mechanism and a stiffness control mechanism. The principles involved in these mechanisms and the structure of each mechanism are detailed, and medical and welfare applications are presented. One of the devices which has been developed is an active bending soft tube using an SMA microcoil actuator. Doctors can control the bending motion of the tip of the tube from outside the body. One application of this tube is the treatment of intestinal obstruction. The tube consists of a bending tip (external diameter, 6 mm; length, 40 mm) and a 3 m long silicone rubber tube. It enables easier and more reliable passage at the lower end of the stomach (pylorus). The maximum bending angle is 110 degrees. Another device we have developed using SMA microcoil actuators is a dynamic tactile pin display which displays Braille characters and graphic information by dynamic up-and-down movement of an array of pins. SMA microcoil actuators enable up-and-down movement of the pins and a magnetic latch mechanism keeps the pins in an up or down state. This two-dimensional pin display consists of 100 (10 x 10) pins with a pin pitch of 2.5 rum, the actuation length of each pin being 2 mm. The tactile information can be displayed sequentially every 0.3 s.

  68. Dynamic Braille display using SMA coil actuator and magnetic latch Peer-reviewed

    Y Haga, W Makishi, K Iwami, K Totsu, K Nakamura, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　119　(2)　316-322　2005/04

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/j.sna.2004.10.001 　

    ISSN：0924-4247

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    Braille points are varied arrangements of raised dots representing characters which are identified by touch by visually impaired people. A dynamic Braille display which presents Braille points by the up-and-down movement of pins using shape memory alloy (SMA) coil actuators and a magnetic latch has been developed. When the SMA coil actuator is heated by the flow of an electrical current, the compressed SMA extends, causing the pins to move up or down. The magnetic latch mechanism keeps the pins in an up or down state and solves the problem of heat storage and power consumption of the SMA actuator. Six Braille points (2 x 3) represent one character, the distances between the points being 2-3 mm. In order to fabricate a dense array of the SMA-actuated dynamic pins, Ni electroplating is utilized for batch forming of electrical connections between the SMA coil and the electrode on printed circuit boards. Displacement and latching power of each fabricated pin are sufficient for dynamic Braille. Sixteen pins representing two characters and two cursors are modularized to realize a line of dynamic Braille characters by lining up the modules. A control circuit and a driving circuit are mounted on each module to reduce the number of lead wires. (c) 2004 Elsevier B.V. All rights reserved.

  69. Design and characteristics of large displacement optical fiber switch Peer-reviewed

    MMI Bhuiyan, Y Haga, M Esashi

    IEEE JOURNAL OF QUANTUM ELECTRONICS　41　(2)　242-249　2005/02

    Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

    DOI： 10.1109/JQE.2004.839681 　

    ISSN：0018-9197

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    Plastic optical fiber (POF) is suitable for indoor local area network (LAN), for example, in-home or office networks, because of its flexibility and its ease of connection due to its relatively large core diameter. A 1 x 2 optical switch for indoor LAN using POF and a shape memory alloy (SMA) coil actuator with magnetic latches was successfully fabricated and tested. In this paper, the design concept and the characteristics of this switch are described. To achieve switching by the movement of a POF, large displacement is necessary because the core diameter is large (e.g., 0.486 mm). A SMA coil actuator is used for large displacement and a magnetic latching system is employed for fixing the position of the shifted POF. For this design, the insertion loss is 0.40 to 0.50 dB and crosstalk is more than -50 dB without index-matching oil. Switching speed is less than 0.5 s at a driving current of 80 mA. A cycling test was performed 1.4 million times at room temperature. Another optical fiber switch was fabricated and successfully actuated using plastic clad fiber (PCF). PCF also has a large core diameter (e.g., 0.20 mm) and optical switches using PCF will be useful for short distance networks between buildings.

  70. 形状記憶合金を用いた能動屈曲電子内視鏡 Peer-reviewed

    牧志 渉, 松永忠雄, 江刺正喜, 芳賀洋一

    第14回日本コンピュータ外科学会大会　59-60　2005

  71. Ultra-miniature fiber-optic pressure sensor using white light interferometry Peer-reviewed

    K Totsu, Y Haga, M Esashi

    JOURNAL OF MICROMECHANICS AND MICROENGINEERING　15　(1)　71-75　2005/01

    Publisher: IOP PUBLISHING LTD

    DOI： 10.1088/0960-1317/15/1/011 　

    ISSN：0960-1317

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    We have developed a fiber-optic Fabry-Perot interferometric pressure sensor of 125 mum in diameter and a detection system for medical use. A Fabry-Perot cavity is formed at an optical fiber end. A deformation of the diaphragm of the Fabry-Perot cavity induced by pressure varies the cavity length. White light interferometry is used to avoid error and noise caused by bending of the optical fiber and fluctuation of the light source. The reflection light of the sensor cavity is detected by a commercial high-speed spectrometer. A pressure change has been detected by using the developed sensor system. Animal experiments using a goat have been carried out and dynamic pressure changes in the internal pressure of heart and aorta have been successfully monitored.

  72. Project artificial myocardium Peer-reviewed

    YAMBE Tomoyuki, MATSUKI Hidetoshi, HAGA Yoichi, ESASHI Masayoshi, MARUYAMA Shigenao, TAKAGI Toshiyuki, HIGA Masaru, LUO Yun, SHIRAISHI Yasuyuki, YAMAGUCHI Tasuku, SHIBATA Mune-ichi, NITTA Shinichi, YOSHIZAWA Makoto, TANAKA Akira, ABE Ken-ichi, SATO Fumihiro

    Journal of Advanced Science　17　(1)　118-125　2005

    Publisher: Society of Advanced Science

    DOI： 10.2978/jsas.17.118 　

    ISSN：0915-5651

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    Where is a place to be assisted for the patients with congestive heart failure? It is contraction of myocardium. We do not need to exchange the whole hearts. We started the ARTIFICIAL MYOCARDIUM development project. In the first step, pneumatic drive type artificial myocardium was developed. Next, development of an implantable type device was started. The animal experiment which studies the direct ventricle supporting effect by this motor was conducted. Although cardiac assistance of the right ventricle was enough as a result of repeating an animal experiment, the left ventricle supporting effect was inadequate. By such reason, we planned the development of an electrohydraulic driving system with grass fiber belt for fixation. The drive system with which it equipped between ribs controls silicon oil in our plan. Energy is supplied by transcutaneous energy transmission system from the outside of the body. As the results, this device is easily attached to the ventricle and the left ventricle and the right ventricle were able to be assisted as a result of the animal experiment. The cardiac output increased and blood pressure rose in the time series data during artificial myocardium support. Since this device is not a pump, it does not have a valve and does not have the risk of a thrombus, either. Therefore, it is also possible to implant in prevention to a slight heart failure patient. It is expected that it becomes an important artificial organ with a big market.

  73. 形状記憶合金を用いた腸閉塞治療用能動カテーテル Peer-reviewed

    水島昌徳, 芳賀洋一, 戸津健太郎, 江刺正喜

    日本コンピュータ外科学会誌　6　(1)　23-29　2004/06/30

    DOI： 10.5759/jscas1999.6.23 　

  74. Three-axis magneto-impedance effect sensor system for detecting position and orientation of catheter tip Peer-reviewed

    K Totsu, Y Haga, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　111　(2-3)　304-309　2004/03

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/j.sna.2003.11.018 　

    ISSN：0924-4247

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    A catheter-based minimally invasive therapy requires real time information about the position and orientation of a catheter tip for safe operation. To decrease X-ray exposure and to provide 3D information for operators, a simple sensor system for detecting the position and orientation utilizing the earth's magnetic field and ac (10 kHz) magnetic field transmitted by a two-axis source coil is proposed. A 2 mm x 2 mm x 3 mm three-axis MI sensor (Magneto-Impedance effect sensor) fabricated on a polymer structure for measuring the earth's magnetic field and the ac magnetic field is mounted on the catheter tip. The advantages of this sensor are: (1) small size; (2) high sensitivity; (3) retaining of through hole. The position and orientation is calculated and the obtained information of the position and orientation of the catheter tip is superimposed on the 3D map of the blood vessel captured in advance. A measurement in a blood vessel model has been performed and the calculated position and orientation image has been superimposed on the 3D graphic image of the blood vessel. The sensor system obviously indicated where the catheter tip was in the "y" shape blood vessel model. (C) 2003 Elsevier B.V. All rights reserved.

  75. 形状記憶合金アクチュエータを応用した人工食道開発 Peer-reviewed

    山家智之, 堀, 義生, 渡辺, 誠, 白石泰之, 井口篤志, 田林胱一, 芳賀洋一, 江刺正喜, 吉澤 誠, 田中, 明, 松木英敏, 佐藤文博, 川野恭之, 羅 雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 宮田 剛, 里見, 進, 本間, 大, 前田 剛

    日本AEM学会誌　12　(2)　94-99　2004/03

  76. Biomedical microsystems for minimally invasive diagnosis and treatment Peer-reviewed

    Y Haga, M Esashi

    PROCEEDINGS OF THE IEEE　92　(1)　98-114　2004/01

    Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

    DOI： 10.1109/JPROC.2003.820545 　

    ISSN：0018-9219

    eISSN：1558-2256

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    Great significant progress has been made in the development of biomedical microdevices in recent years, and these devices are, now playing an important role in diagnosis and therapy. This paper presents a review of applications of microelectromechanical systems (MEMS) devices for in vivo diagnosis and therapy, and endoscopic and catheter-based interventions. MEMS technology has enabled the further development of advanced biomedical microdevices for use in the human body by integration of sensors, actuators, and electronics into small medical devices for use in the body. In this paper we discuss three categories of such devices: navigation systems, sensors and actuators for catheters and endoscopes, and other minimally invasive techniques. A brief introduction to principles, device structures, packaging, and related issues is presented.

  77. Biomedical microsystems for minimally invasive diagnosis and treatment Peer-reviewed

    Y Haga, M Esashi

    PROCEEDINGS OF THE IEEE　92　(1)　98-114　2004/01

    Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

    DOI： 10.1109/JPROC.2003.820545 　

    ISSN：0018-9219

    eISSN：1558-2256

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    Great significant progress has been made in the development of biomedical microdevices in recent years, and these devices are, now playing an important role in diagnosis and therapy. This paper presents a review of applications of microelectromechanical systems (MEMS) devices for in vivo diagnosis and therapy, and endoscopic and catheter-based interventions. MEMS technology has enabled the further development of advanced biomedical microdevices for use in the human body by integration of sensors, actuators, and electronics into small medical devices for use in the body. In this paper we discuss three categories of such devices: navigation systems, sensors and actuators for catheters and endoscopes, and other minimally invasive techniques. A brief introduction to principles, device structures, packaging, and related issues is presented.

  78. Artificial myocardium with an artificial baroreflex system using nano technology Peer-reviewed

    T Yambe, Y Shiraishi, M Yoshizawa, A Tanaka, K Abe, F Sato, H Matsuki, M Esashi, Y Haga, S Maruyama, T Takagi, Y Luo, E Okamoto, Y Kubo, M Osaka, S Nanka, Y Saijo, Y Mibiki, T Yamaguchi, M Shibata, S Nitta

    BIOMEDICINE & PHARMACOTHERAPY　57　(1)　122S-125S　2003/10

    Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

    DOI： 10.1016/j.biopha.2003.08.016 　

    ISSN：0753-3322

    eISSN：1950-6007

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    Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the heart. At Tohoku University, development research of "the artificial myocardium" has been conducted, using a ball screw type electromagnetic motor. Furthermore, super-miniaturization is being attempted at present. Thus, a system with shape memory alloy is being developed. The cooling speed problem was solved by the application of the Peltier element. A drive at a speed equal to that of a heartbeat was realized by the application of this system. At present, a ventricular assist device is used for patients waiting for a heart transplant in Japan. An air driven type system disturbs a patient's QOL remarkably because it is connected to the drive device. With our concept, energy is provided by using the electromagnetic force from outside of the body by the use of transcutaneous energy transmission system. Magnetic shielding by amorphous fibers was used at Tohoku University to improve the total efficiency. A natural heart can alter the cardiac output corresponding to the demand. Artificial internal organs must participate in the system of the living body, too. Tohoku University has developed a resistance based artificial heart control algorithm, which simulated a baroreflex system to cope with every demand. Nano level sensing equipment is now under development at Tohoku University. At present, development is being conducted aiming at an "intelligent artificial myocardium". (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

  79. Artificial myocardium with an artificial baroreflex system using nano technology. Peer-reviewed

    Yambe T, Shiraishi Y, Yoshizawa M, Tanaka A, Abe K, Sato F, Matsuki H, Esashi M, Haga Y, Maruyama S, Takagi T, Luo Y, Okamoto E, Kubo Y, Osaka M, Nanka S, Saijo Y, Mibiki Y, Yamaguchi T, Shibata M, Nitta S

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie　57 Suppl 1　122s-125s　2003/10

    ISSN：0753-3322

  80. Batch fabrication of intravascular forward-looking ultrasonic probe Peer-reviewed

    Y Haga, M Fujita, K Nakamura, CJ Kim, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　104　(1)　40-43　2003/03

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/S0924-4247(02)00480-6 　

    ISSN：0924-4247

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    An intravascular forward-looking ultrasonic probe has been fabricated using batch fabrication. This probe consists of eight separated elements ring array 1-3 composite transducer and a backing made from conductive epoxy. The conductive epoxy backing works not only acoustic dumping material but also electrical interconnection. Almost same impedance properties and pulse-echo waveform from each of the eight elements have been measured. Reflected pulse-echo by an acrylic plate placed at appropriately 4.5 mm front of the probe has been detected from each of the eight transducer elements in water. (C) 2002 Elsevier Science B.V. All rights reserved.

  81. 非平面フォトファブリケーションによる形状記憶合金パイプからのアクチュエータ作製 Peer-reviewed

    峯田貴, 芳賀洋一, 江刺正喜

    電気学会論文誌E　123　(5)　158-162　2003/03

    DOI： 10.1541/ieejsmas.123.158 　

  82. Bach fabrication of microlens at the end of optical fiber using self-photolithgraphy and etching techniques Peer-reviewed

    Phan Ngoc Minh, Takahito Ono, Yoichi Haga, Kazumi Inoue, Minoru Sasaki, Kazuhiro Hane, Masayoshi Esashi

    Optical Review　10　(3)　150-154　2003

    DOI： 10.1007/s10043-003-0150-4 　

    ISSN：1340-6000

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    This paper describes a simple batch process for fabrication of microlens and microlens array at the end of an optical fiber or an optical fiber bundle using self-photolithography and etching techniques. A photoresist micro-cylinder was exactly formed at the core of the fiber end by exposing an UV light from the other end of the fiber and conventional development, rinse processes. A photoresist microlens was formed by thermal reflowing of the fiber at 170°C for 1 h. A measurement of transmissivity showed that the fabricated photoresist microlens is applicable for a wavelength that is longer than 450 nm. Alternatively, a glass microlens was fabricated at the core of the fiber by dry etching with an SF6 gas using the photoresist microlens as a mask. The focusing of the lensed fiber was confirmed and simulation work showed that the lensed fiber could focus the light with a beam spot of 2 μm. numerical aperture (NA) of 0.285 and a depth of focus of 16 μm.

  83. An active guide wire with shape memory alloy bending actuator fabricated by room temperature process Peer-reviewed

    T Mineta, T Mitsui, Y Watanabe, S Kobayashi, Y Haga, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　97-8　632-637　2002/04

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/S0924-4247(02)00021-3 　

    ISSN：0924-4247

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    An active guide wire of 0.5 mm outer diameter has been developed. The guide wire has a simple and flexible structure that consists of a NiTi shape memory alloy (SMA) bending actuator with meandering shape and a bias coil that is covered with thin polyurethane, tube. It can bend to one-direction by heating with electric current and is restored by the bias coil. Large current was necessary to bend the guide wire in water, however, it could bend over 60degrees. The rise of the surface temperature of the guide wire was less than 5 degreesC in water. The SMA bending actuator has been photo-fabricated from a flatten SMA sheet which was spread flat after it was memorized in curve-shape. In order to fabricate the actuator below the transition temperature of the SMA. a room temperature photo-fabrication process has been also developed. 2002 Elsevier Science B.V. All rights reserved.

  84. Hybrid optical fiber-apertured cantilever near-field probe Peer-reviewed

    Phan Ngoc Minh, Takahito Ono, Hisashi Watanabe, Seung Soup Lee, Yoichi Haga, Masayoshi Esashi

    Applied Physics Letters　79　(19)　3020-3022　2001/11/05

    DOI： 10.1063/1.1416475 　

    ISSN：0003-6951

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    In this letter, we propose a hybrid optical fiber-apertured cantilever probe for optical near-field applications. A thermal SiO2 cantilever beam with a SiO2 pyramidal tip was formed by Si micromachining technique and bonded with an optical fiber using a polyimide adhesive layer. A subwavelength aperture at the apex of the SiO2 tip was formed by etching the SiO2 in a buffered-HF solution. Optical near-field imaging in contact mode was observed with the fabricated probe. The probe could work in contact mode because the cantilever at the end of the fiber can flexibly move on the sample surface. By detecting the far-field light which is reflected-back by the tip of the cantilever, the vibration of the cantilever was observed using the probe itself. With the proposed structure, a hybrid fiber bundle-apertured cantilever array is feasible for application in parallel near-field processing or data storage. © 2001 American Institute of Physics.

  85. Development of Active Catheter, Active Guide Wire and Micro Sensor Systems Peer-reviewed

    Y. Haga, T. Mineta, K. Totsu, W. Makishi, M. Esashi

    Interventional Neuroradiology　7　(1)　125-130　2001/07

    ISSN：1123-9344

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    Active catheters and active guide wires which move like a snake have been developed for catheter-based minimally invasive diagnosis and therapy. Communication and control IC chips in the active catheter reduce the number of lead wires for control. The active catheter can be not only bent but also torsioned and extended. An ultra minature fiber-optic pressure sensor, a forward-looking ultrasonic probe and a magnetic position and orientation sensor have been developed for catheters and guide wires. These moving mechanisms and several sensors which are fitted near the tip of the catheter and the guide wire will provide detailed information near the tip and enable delicate and effective catheter intervention.

  86. Batch fabricated flat meandering shape memory alloy actuator for active catheter Peer-reviewed

    T. Mineta, T. Mitsui, Y. Watanabe, S. Kobayashi, Y. Haga, M. Esashi

    Sensors and Actuators, A: Physical　88　(2)　112-120　2001/02/15

    Publisher: Elsevier Sequoia SA

    DOI： 10.1016/S0924-4247(00)00510-0 　

    ISSN：0924-4247

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    We have developed a new batch fabrication process of a shape memory alloy (SMA) sheet based on electrochemical pulse etching with a sacrificial dummy metal layer. The method has realized a throughout micromachining of the SMA sheet. Using the new batch fabrication process, flat meandering S-shape SMA actuators of 38 μm in thickness have been developed. The actuators whose widths were narrower than 290 μm could generate the forces over 75 mN. The batch fabrication process was also applied to a micromachining of NiTi super elastic alloy (SEA) helical coils. A small outer diameter active catheter was developed by using the flat meandering SMA actuators of 290 μm in width and the SEA helical coil of about 460 μm in outer diameter. The outer diameter of the catheter without an outer tube was 0.8 mm. A silicon rubber outer tube of 75 μm in wall thickness was put on the catheter, nevertheless, the outer diameter was smaller than 1 mm. The bending angle of the developed active catheter without the outer tube was about 50° at heating current of 60 mA. The bending angle tended to be lower after the outer tube was put on, however, the catheter with outer tube could be bent to the angle of 35°.

  87. 形状記憶合金コイルを用いた細径能動カテーテル Peer-reviewed

    芳賀洋一, 江刺正喜

    電気学会論文誌E　120　(11)　509-514　2000/11

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.120.509 　

    ISSN：1341-8939

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    In recent years, catheter-based interventional diagnosis and therapy have become increasingly popular. However, the operation of the catheter requires certain human skill because conventional catheters can not bend actively for steering. For the bending motion, we have developed active catheters which has many joints of Shape Memory Alloy (SMA) coil actuators in order to move like a snake. Polymer link active catheter which has link structures between the joints, and linkless type active catheters which have no joint were developed. Linkless outskeletal active catheters which have SMA coils inside the linter coil were also developed. This is suitable for practical use in a human body because of its small heat dissipation from the surface.

  88. カテーテル先端の位置・姿勢を検出する磁気センサシステム Peer-reviewed

    戸津 健太郎, 芳賀 洋一, 江刺 正喜

    電気学会論文誌E　120　(5)　211-218　2000/05

    DOI： 10.1541/ieejsmas.120.211 　

  89. 細径能動カテーテルのための螺旋骨格薄肉チューブ Peer-reviewed

    芳賀洋一, 前田重雄, 江刺正喜

    電気学会論文誌E　120　(8/9)　426-431　2000/04

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.120.426 　

    ISSN：1341-8939

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    New fabrication method of small diameter tubular structures which are suitable for active catheters and active guide wires was developed. These tubular structures consist of metal spring coil and evaporated parylene membrane. An anticoagulant polyurethane is used as outer membrane structure. Fabrication process is simple and the fabricated tubes are kink-free and buckling-free in spite of its flexibility and thin wall.

  90. Micromachined 125um(<--μm) Diameter Ultra Miniature Fiber-Optic Pressure Sensor for Catheter Peer-reviewed

    T. Katsumata, Y. Haga, K. Minami, M. Esashi

    Trans. IEE of Japan　120-E　(2)　58-63　2000/03

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.120.58 　

    ISSN：1341-8939

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    A miniaturized fiber-optic pressure sensor 125μm in diameter has been developed for the measurement in human body [1]. The sensing element is fabricated by micromachining, and attached to the end of an optical fiber using polyimide adhesive layer. A Fabry-Perot interferometer is constituted of a half-mirror at the fiber end and a reflection mirror on the movable thin diaphragm. The intensity of the light reflected at the interferometer is modulated by the pressure, because the optical path difference between the two mirrors of the interferometer varies with the displacement of the diaphragm in dependence on the pressure.

  91. Assembly of Bending, Torsional and Extending Active Catheter Using Electroplating Peer-reviewed

    Yoichi Haga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　120　(11)　515-520　2000

    DOI： 10.1541/ieejsmas.120.515 　

    ISSN：1347-5525 1341-8939

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    This paper reports a new batch fabrication method of active catheters which have bending, torsional and extending functions for steering. The active catheter consists of shape memory alloy (SMA) coil actuators and a liner coil to return to its original shape. The SMA coil and the liner coil are connected each other using electroplating of nickel and electrodeposition of acrylic polymer. This novel method makes low cost assembly and small diameter (ϕ1.4mm) possible. © 2000, The Institute of Electrical Engineers of Japan. All rights reserved.

  92. Active Catheter Using Multi-Link-Joint Structure Fabricated in Silicon Wafer Peer-reviewed

    Takashi Mineta, Yoshiyuki Watanabe, Seiya Kobayashi, Yoichi Haga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　119　(12)　615-619　1999

    DOI： 10.1541/ieejsmas.119.615 　

    ISSN：1347-5525 1341-8939

    eISSN：1347-5525

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    An active catheter using silicon multi-link-joint structure has been developed. This catheter has a function of controllable bending motion like a snake by incorporation of distributed shape memory alloy (SMA) coil actuators and restoring silicon springs. The mechanical structure that consists of links and connecting bendable beams was fabricated in silicon wafers by using bulk micromachining technique. This method has an advantage that plural catheters can be fabricated by batch process. © 1999, The Institute of Electrical Engineers of Japan. All rights reserved.

  93. FRACTAL DIMENSION ANALYSIS OF THE OSCILLATED BLOOD-FLOW WITH A VIBRATING FLOW PUMP Peer-reviewed

    T YAMBE, T SONOBE, S NAGANUMA, S KOBAYASHI, S NANKA, H AKIHO, Y KAKINUMA, M MITSUOKA, S CHIBA, N OHSAWA, Y HAGA, K IDUTSU, S NITTA, T FUKUJU, M MIURA, N UCHIDA, N SATO, K TABAYASHI, A TANAKA, N YOSHIZUMI, K ABE, M TAKAYASU, H TAKAYASU, M YOSHIZAWA, T MAEKAWA, H HASHIMOTO

    ARTIFICIAL ORGANS　19　(7)　729-733　1995/07

    Publisher: BLACKWELL SCIENCE PUBL INC CAMBRIDGE

    ISSN：0160-564X

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    To analyze the hemodynamic parameters during circulation with oscillated blood flow, nonlinear mathematical analyzing techniques, including fractal theory, were utilized, Vibrating flow pumps (VFP) were implanted as a left heart bypass, and the ascending aorta was clamped to constitute the total left heart circulation with oscillated blood flow in acute animal experiments using 7 adult goats. Using nonlinear mathematical analyzing techniques, reconstructed attractors of the arterial blood pressure waveform in the phase space during natural circulation and oscillated circulation were analyzed, Using the Grassberger-Procaccia correlation dimension analyzing technique, fractal dimension analysis of the reconstructed attractor was performed. During VFP bypass, lower fractal dimensions of the reconstructed attractor were shown compared with those during natural heart circulation. The results suggest that lower dimensional chaotic dynamics contributed to the circulation with oscillated blood flow.

  94. 「脈診」における決定論的カオス Peer-reviewed

    山家智之, 仁田新一, 高橋和彦, 密岡幹夫, 千葉茂樹, 薗部太郎, 西條芳文, 永沼 滋, 柿沼義人, 井筒憲司, 永沼 徹, 小林信一, 佐々木英彦, 芳賀洋一, 南家俊介, 大沢 上, 田中元信, 吉沢 誠, 小出 訓, 阿部健一, 竹田 宏, 高島 充, 佐藤由樹, 渥美和彦

    自律神経　31　85-91　1994/04

  95. 人工心臓による循環は決定論的カオスの法則に従うか？

    山家智之, 仁田新一, 薗部太郎, 永沼滋, 秋保洋, 柿沼義人, 小林信一, 芳賀洋一, 井筒憲司, 南家俊介, 田中元直, 福寿岳雄, 三浦誠, 内田直樹, 佐藤尚, 毛利平, 小出訓, 阿部健一, 竹田宏, 吉澤誠, 阿部裕輔, 井街宏, 鎮西恒雄, 満渕邦彦, 藤正厳

    人工臓器　23　(3)　545-550　1994/04

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.23.545 　

    ISSN：0300-0818

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    In order to analyze the hemodynamics with artificial heart as an entity, not as the decomposed one, non-linear mathematical analyzing technique was utilized in chronic animal experiments using adult goats. For the comparison between the natural and artificial circulation, biventricular assist type total artificial circulation was adopted. After the implantation procedure, the goats were placed in the cage and hemodynamics with natural and artificial circulation were recorded under the awake conditions. Hemodynamic time series data were embedded into the four dimensional phase space and projected into the three dimensional phase space. During artificial circulation, reconstracted attractor showed lower dimensional chaotic behavior compared with natural circulation. Existence of deterministic chaos was suggested by the positive Lyapunov exponents. Our results suggest that circulation with artificial heart may be able to become the flexible and intelligent system by the achivement of the chaotic dynamics.

  96. Evaluation of the air driven pump chamber used in the ventricular assist device by hydrodynamic analysis of the prosthetic valve Peer-reviewed

    TOMOYUKI YAMBE, SHIN-ICHI NITTA YOSHIAKI, KATAHIRA TAROH, SONOBE YOSHIFUMI SAIJOH SHIGERU, NAGANUMA HIROSHI AKIHO YOSHITO, KAKINUMA HIDEHIKO SASAKI KENJI IZUTSU, YUH-ICHI KIKUCHI SHIN-ICHI, KOBAYASHI, YOU-ICHI HAGA MOTONAO TANAKA MAKOTO MIURA NAOSHI SATO HITOSHI, MOHRI MAKOTO, YOSHIZAWA HIROSHI, TAKEDA TOSHIO, NAGASE AKIRA FUKUTOME, RYUHICHIRO YOTA

    Artificial Organs Today　2　(4)　279-285　1993/10

  97. Identification of the Deterministic Chaos in Cardiovascular Dynamics by the Use of the Non-Linear Mathematics Peer-reviewed

    Tomoyuki Yambe, Shin-ichi Nitta Taro Sonobe, Shigeru Naganuma, Shin-ichi Kobayashi, Yoh-ichi Haga Motonao, Tanaka Takeo Fukuju Makoto Miura, Naoshi Sato, Hitoshi Mohri Makoto Yoshizawa Satoshi, Koide Kouhei Tamura, Hiroshi Takeda

    Science of Reports of the Research Institutes Tohoku University Series C　39　1-5　1993/03

  98. 可逆性心筋虚血回復過程における左心補助の有効性 - V0およびEmaxの経時的変動の検討 Peer-reviewed

    柿沼義人, 仁田新一, 片平美明, 山家智之, 薗部太郎, 永沼滋, 秋保洋, 井筒憲司, 小林信一, 芳賀洋一, 田中元直, 三浦誠, 佐藤尚, 毛利平, 竹田宏, 吉澤誠

    人工臓器　22　(3)　718-723　1993/03

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.718 　

    ISSN：0300-0818

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    In order to evaluate the effect of the left ventricular assist device (LVAD) on the transient myocardial ischemia, acute animal experiments of the left heart bypass were carried out using the model of transient ischemia obtained by ligaturing the proximal portion of a left anterior descending coronary artery. In this study, the maximum value of elastance (Emax) was calculated using pressure-volume curve (P-V curve), based on the hypothesis that the volume of zero (Vo) is constant during the experimental procedure. But, because of the possibility that the value of Vo may vary according to the circulatory conditions, it is necessary to evaluate the change of Vo on different conditions. Therefore, the value of Vo on three different conditions of transient myocardial ischemia were calculated from the data obtained by inserting ten beats of co-pulsation mode between two series of counter-pulsation mode. In those experiments, per-cent changes of Vo during occlusion and after re-perfusion were 105.5% and 98.8%, respectively. On the contrary, the Emax during occlusion showed significant per-cent reduction (51.5%) compared with the Emax after re-perfusion (104.3%). It was concluded that the variability of Vo was too small to produce effect on the Emax calculated from P-V curve by assuming the constant Vo. Our method, with which time-series data of Emax could be obtained, might produce a useful information concerning cardiac function.

  99. 人工心臓を用いた生体時系列曲線の揺らぎの成因に関する実験的研究 Peer-reviewed

    山家智之, 仁田新一, 片平美明, 薗部太郎, 永沼滋, 秋保洋, 柿沼義人, 小林信一, 芳賀洋一, 井筒憲司, 田中元直, 福寿岳雄, 三浦誠, 内田直樹, 佐藤尚, 毛利平, 小出訓, 竹田宏, 吉沢誠

    人工臓器　22　(3)　754-759　1993/03

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.754 　

    ISSN：0300-0818

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    In order to analyze the origin of the rhythmical fluctuations in hemodynamic parameters by the use of the spectral analyzing method, artificial heart, which have not the periodicities, were implanted in the adult goats. Two pneumatically actuated sac type blood pump were implanted as the biventricular bypass (BVB) to constitute the BVB type total artificial heart (TAH) model to compare the fluctuations in natural heart animal and TAH animal. After the BVB pumping was initialized, natural heart was electrically fibrillated. During artificial circulation, significant Mayer waves and respiratory waves were clearly shown. Spectral analyzing method including coherence function revealed the fact that Mayer waves were originated from the peripheral vascular resistance, and respiratory waves were originated from the pulmonary circulation. These results suggest that rhythmical fluctuations in cardiovascular variabilities were at least, partly originated from the non-cardiogenic periodicities.

  100. 電磁駆動式振動流ポンプを応用した人工心肺シ ステムの脳動脈血流量に与える影響に関する実験的研究 Peer-reviewed

    小林信一, 仁田新一, 片平美明, 山家智之, 薗部太郎, 永沼滋, 柿沼義人, 秋保 洋, 芳賀洋一, 田中元直, 福寿岳雄, 三浦誠, 佐藤尚, 毛利平, 橋本弘之, 葛西 毅, 桧山浩国, 若井秀二, 吉澤誠

    人工臓器　22　(3)　915-920　1993/03

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.915 　

    ISSN：0300-0818

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    We have been developing the artificial heart using the vibrating flow pump (VFP), which can generate the high frequency blood flow. To determine the effect of high frequency blood flow on the hemodynamics, cardiopulmonary bypass (CPB) using VFP was performed in four adult goats. The carotid arterial flow (CAF) was recorded by the use of ultrasonic flow meter to estimate the effect of high frequency blood flow upon blood flow distribution. During 30Hz flow, the carotid arterial resistanse (CAR) was significantly decreased, though, the total peripheral resis-tance (TPR) was not significantly changed. On the other hand, both CAR and TPR was decreased during 10Hz flow. These results suggest that the frequency of blood flow affects the blood flow distribution during CPB.

  101. Power spectral analysis of rhythmical fluctuations in hemodynamic parameters during prosthetic high frequency blood flow Peer-reviewed

    T. Yambe, S. Nitta, T. Sonobe, S. Naganuma, Y. Kakinuma, S. Kobayashi, Y. Haga M, Tanaka, T. Fukuju, M. Miura, N. Sato, H. Mohri, M. Yoshizawa, S. Koide, H. Takeda, H. Hiyama, M. Aoki, T, Kasai, H. Hashimoto

    Artificial Organs Today　3　99-105　1993/02

  102. Estimation of the ventricular assist device during condition from the neurophysiological point of view Peer-reviewed

    TOMOYUKI YAMBE, SHIN-ICHI NITTA YOSHIAKI, KATAHIRA TAROH, SONOBE SHIGERU, NAGANUMA HIROSHI MATSUZAWS HIROSHI AKIHO, SHIGEKI CHIBA YOSHITO KAKINUMA KENJI IZUTSU, YUH-ICHI KIKUCHI SHIN-ICHI, KOBAYASHI, YOU-ICHI HAGA MOTONAO TANAKA MAKOTO MIURA NAOSHI SATO HITOSHI, MOHRI MAKOTO YOSHIZAWA, HIROSHI TAKEDA

    Artificial Organs Today　2　309-316　1993/01

  103. 東北大学型補助人工心臓における内面処理による抗血栓性の向上 Peer-reviewed

    仁田新一, 山家智之, 片平美明, 薗部太郎, 永沼 滋, 柿沼義人, 井筒憲司, 小林信一, 芳賀洋一, 田中元直, 福寿岳雄, 三浦 誠, 佐藤 尚, 毛利 平

    抗酸菌病研究所雑誌　44　(3)　309-313　1992/11

  104. 決定論的カオスと人工心臓 Peer-reviewed

    山家智之, 仁田新一, 片平美明, 薗部太郎, 永沼 滋, 柿沼義人, 小林信一, 芳賀洋一, 井筒憲司, 永沼 徹, 田中元直, 福寿岳雄, 三浦 誠, 佐藤 尚, 毛利 平, 和泉恭一郎, 小出 訓, 竹田 宏, 吉沢 誠

    抗酸菌病研究所雑誌　44　(3)　315-322　1992/11

  105. 線形システム解析による人工心臓制御 Peer-reviewed

    山家智之, 仁田新一, 片平美明, 薗部太郎, 永沼 滋, 柿沼義人, 小林信一, 芳賀洋一, 井筒憲司, 永沼 徹, 田中元直, 福寿岳雄, 三浦 誠, 佐藤 尚, 毛利 平, 和泉恭一郎, 小出 訓, 竹田 宏, 吉沢 誠

    抗酸菌病研究所雑誌　44　(3)　323-336　1992/11

  106. 機械的補助循環がstunned myocardiumにおける自律神経機能に与える影響 Peer-reviewed

    山家智之, 仁田新一, 片平美明, 薗部太郎, 永沼 滋, 柿沼義人, 小林信一, 芳賀洋一, 井筒憲司, 永沼 徹, 田中元直, 福寿岳雄, 三浦 誠, 佐藤 尚, 毛利 平, 和泉恭一郎, 小出 訓, 竹田 宏, 吉沢 誠

    抗酸菌病研究所雑誌　44　(3)　337-343　1992/11

  107. 高速振動流が自律神経機能に与える影響 Peer-reviewed

    山家智之, 仁田新一, 片平美明, 薗部太郎, 永沼 滋, 柿沼義人, 秋保 洋, 井筒憲司, 小林信一, 芳賀洋一, 松澤 浩, 田中元直, 福寿岳雄, 三浦 誠, 佐藤 尚, 毛利 平, 和泉恭一郎, 小出 訓, 竹田 宏, 橋谷 浩, 吉沢 誠, 檜山浩国, 葛西 毅, 橋本弘之

    人工臓器　21　(5)　1390-1394　1992/05

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.21.1390 　

    ISSN：0300-0818

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    We have been developing the artificial heart using the vibrating flow pump (VFP), which can generate the high frequency blood flow about 10Hz/s. To determine the effect of high frequency blood flow on autonomic nervous system under general anestesia, fluctuations in hemodynamics was analyzed by the spectral analysing method. Our newly developped VFP was utilized as the total left heart bypass in acute experiments using adult goats. During VFP pumping, respiratory waves were<br>not significantly changed (N.S.), though Mayer waves were significantly decreased (p<0.05). These results suggest that high frequency blood flow affects the autonomic nervous system, even during anesthesia.

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Misc. 177

  1. 体腔内手術における対象臓器と手技を考慮したデバイス設計支援シミュレータ

    後藤彰汰, 鶴岡典子, 芳賀洋一

    日本生体医工学会大会プログラム・抄録集(Web)　62nd　2023

  2. Device Design Assistance Simulator Considering Target Organ and Technique in Intracorporeal Surgery

    後藤彰汰, 鶴岡典子, 芳賀洋一, 芳賀洋一

    日本生体医工学会大会プログラム・抄録集(Web)　62nd　2023

  3. 超音波によるキャビテーションを利用した粘膜組織からの細胞採取デバイス—Cell Collection Device from Mucosal Tissue Using Cavitation Caused by Ultrasound Irradiation

    葉 煬, 上地 達哉, 鶴岡 典子, 明石 真, 芳賀 洋一

    日本コンピュータ外科学会誌 = Journal of Japan Society of Computer Aided Surgery / 日本コンピュータ外科学会 編　24　(4)　217-225　2023/01

    Publisher: 日本コンピュータ外科学会

    ISSN：1344-9486

  4. Micro-Robotic Medical Tools Employing SMA Actuators for Use in the Human Body

    Yoichi Haga, Takashi Mineta, Tadao Matsunaga, Noriko Tsuruoka

    JOURNAL OF ROBOTICS AND MECHATRONICS　34　(6)　1233-1244　2022/12

    Publisher: FUJI TECHNOLOGY PRESS LTD

    DOI： 10.20965/jrm.2022.p1233 　

    ISSN：0915-3942

    eISSN：1883-8049

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    Several micro-robotic medical tools, including catheters, guide wires, and endoscopes, employing shape memory alloy (SMA) actuators have been proposed and developed for use in the human body. This paper describes the basic principle of SMAs and the characteristics of several mechanisms, such as unidirectional bending, multi-directional bending, torsional movement, extension, and stiffness control. Moreover, some medical applications, such as insertion assistance and endoscopic and laser positioning, are described.

  5. 陰圧駆動可能な2層型気泡除去機能付き酵素電極センサによる連続的成分濃度計測—Continuous concentration monitoring using enzyme electrode sensor with two layer bubble removal flow channel which can be used in negative pressure system

    鶴岡 典子, 継枝 健太, 芳賀 洋一

    「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編]　39　6p　2022/11

    Publisher: Institute of Electrical Engineers of Japan

  6. 光干渉を用いた手術ロボット用小型力センサの一括作製—Batch fabrication of miniature force sensors using optical interference for surgical robots

    樫村 祐貴, 鶴岡 典子, 芳賀 洋一

    「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編]　39　6p　2022/11

    Publisher: Institute of Electrical Engineers of Japan

  7. 皮内生体成分計測を目指した光導波路付き極低侵襲針の窓形状の違いによる性能比較—Performance comparison depends on optical window shape of minimally invasive needle with optical waveguides for measuring subepidermal biological substances

    森 啓悟, 鶴岡 典子, 芳賀 洋一

    「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編]　39　6p　2022/11

    Publisher: Institute of Electrical Engineers of Japan

  8. ケミカルセンサ ケンキュウカイ 【 E ブモン ソウゴウ ケンキュウカイ 】 ケミカル ・ バイオセンサ ト ソノ プロセス ギジュツ オヨビ イッパン

    2022　(20-35)　33-38　2022/06

    Publisher: 電気学会

  9. 皮内生体成分計測を目指した光導波路付き極低侵襲針の作製及び導光評価—Fabrication and light guiding evaluation of minimally invasive needle with optical waveguides for measuring subepidermal biological substances—マイクロマシン・センサシステム研究会 E部門総合研究会 マイクロマシン・センサシステムとそのプロセス技術および一般

    森 啓悟, 鶴岡 典子, 芳賀 洋一

    電気学会研究会資料. MSS　2022　(26-44)　63-68　2022/06

    Publisher: 電気学会

  10. DEVELOPMENT OF AN AUTOMATED IRRIGATION SYSTEM SYNCHRONIZED WITH AN ULTRA-MINIATURE FIBER-OPTIC PRESSURE SENSOR FOR REGULATING INTRAPELVIC PRESSURE DURING URETEROSCOPY: AN EX VIVO PRECLINICAL STUDY

    Takashi Yoshida, Tadao Matsunaga, Noriko Tsuruoka, Hidefumi Kinoshita, Youichi Haga

    JOURNAL OF UROLOGY　207　(5)　E531-E532　2022/05

    Publisher: LIPPINCOTT WILLIAMS & WILKINS

    ISSN：0022-5347

    eISSN：1527-3792

  11. Cell Collection Device from Mucosal Tissue Using Cavitation Caused by Ultrasound Irradiation

    Yang Ye, 上地達哉, 鶴岡典子, 明石真, 芳賀洋一, 芳賀洋一

    日本コンピュータ外科学会誌(Web)　24　(4)　2022

    ISSN：1884-5770

  12. Bubble removal evaluation of enzyme electrode sensor with two-layer bubble removal flow channel which can be used in negative pressure system

    鶴岡典子, 継枝健太, 芳賀洋一

    電気学会研究会資料(Web)　(CHS-22-020-035)　2022

  13. Fabrication and light guiding evaluation of minimally invasive needle with optical waveguides for measuring subepidermal biological substances.

    森啓悟, 鶴岡典子, 芳賀洋一

    電気学会研究会資料(Web)　(MSS-22-026-044)　2022

  14. Estimation of Blood Pressure Using Ultrasonic Blood Vessel Diameter Sensor

    FAN Wenfei, 永島史也, 鶴岡典子, 芳賀洋一, 芳賀洋一

    日本生体医工学会大会プログラム・抄録集(Web)　61st　2022

  15. 皮膚微小還流システムのための気泡除去流路の作製と気泡の除去性能評価—Fabrication and bubble removal function evaluation of bubble removal flowchannel for skin microperfusion system

    継枝 健太, 鶴岡 典子, 芳賀 洋一

    「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編]　38　6p　2021/11

    Publisher: Institute of Electrical Engineers of Japan

  16. Cell collecting device by micro vibration and cavitation generated by ultrasonic irradiation

    YANG Ye, 芳賀洋一, 鶴岡典子, 明石真

    日本生体医工学会大会プログラム・抄録集(Web)　60th　2021

  17. Non-planar Micro Components Including Internal Wiring and Electronic Parts for Endoscopes

    JIANG Cheng, 鶴岡典子, 芳賀洋一

    日本生体医工学会大会プログラム・抄録集(Web)　60th　2021

  18. バイオニックヒューマノイドによる医療革命

    原田香奈子, 原田香奈子, 松永忠雄, 芳賀洋一, 光石衛, 丸山央峰, 新井史人

    光技術コンタクト　56　(11)　25‐31　2018/11/20

    ISSN：0913-7289

  19. Development of robotic forceps that can measure the grasping force by optical fiber based miniaturized modular force sensors

    中塚俊樹, 松永忠雄, 芳賀洋一, 北畠新太郎, 高山隆志, 原田香奈子, 光石衛, 荒田純平

    日本コンピュータ外科学会誌　20　(4)　295‐296-296　2018/10/26

    Publisher: (一社)日本コンピュータ外科学会

    ISSN：1344-9486

  20. 3Dプリンタを用いたPVA‐H血管モデル作製用複合機の開発(第一報)

    長野凌太, 清水康智, 吉田洋, 松永忠雄, 葛迫淳一, 木原信宏, 芳賀洋一, 芳賀洋一, 太田信, 太田信

    日本シミュレーション外科学会会誌　26　(2)　127-127　2018/10

    Publisher: 日本シミュレーション外科学会

    ISSN：1348-6918

  21. Fabrication and electrical characterization of a thin tube-shaped neural electrodes with endoscopic observation function

    池田尚人, LU Wenguang, 松永忠雄, 鶴岡典子, 虫明元, 小山内実, 大城朝一, 芳賀洋一

    電気学会研究会資料　(MSS-18-007-015.017.019-029)　11‐14　2018/07/12

  22. Minimally invasive cell collection device from body surface using ultrasonic transducer and fine needle

    YE Yang, 上地達哉, 鶴岡典子, 松永忠雄, 芳賀洋一

    電気学会研究会資料　(MSS-18-007-015.017.019-029)　77‐81　2018/07/12

  23. 光ファイバを用いた微細モジュール式力覚センサ

    中塚俊樹, 新田達也, 川端友徳, 松永忠雄, 芳賀洋一, 北畠新太郎, 高山隆志, 原田香奈子, 光石衛, 荒田純平

    日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM)　2018　ROMBUNNO.1P1‐J02　2018/06/01

  24. 光ファイバ圧センサを搭載した脳べらの作製と脳モデルを用いた脳圧排圧評価

    川端友徳, 松永忠雄, 森田明夫, 黒江聡嗣, 鶴岡典子, 原田香奈子, 原田香奈子, 芳賀洋一

    日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM)　2018　ROMBUNNO.1P1‐K06　2018/06/01

  25. バイオニックヒューマノイド搭載のための血管モデルの開発

    清水康智, YU Kaihong, TUPIN Simon, 吉田洋, 松永忠雄, 益田泰輔, 金太一, 庄島正明, 芳賀洋一, 新井史人, 原田香奈子, 原田香奈子, 太田信

    日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM)　2018　ROMBUNNO.1P1‐J03　2018/06/01

  26. Position Controlling Mechanism of Laser Irradiation in Flexible Transurethral Lithotripsy (f-TUL)

    太刀岡俊樹, 松永忠雄, 棚橋善克, 鶴岡典子, 芳賀洋一, 芳賀洋一

    日本コンピュータ外科学会誌　20　(2)　77‐85-85　2018/05/31

    Publisher: (一社)日本コンピュータ外科学会

    DOI： 10.5759/jscas.20.77 　

    ISSN：1344-9486

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    軟性尿管鏡を用いた経尿道的尿管結石破砕術(f-TUL)に広く用いられる内視鏡である、URF TYPE Vでの使用を前提とし、f-TULのための能動屈曲機構を作製し、腎盂・腎杯モデルを用いて評価した。屈曲方向に合わせて着色した赤黒青の3種類の色は、内視鏡視野内で容易に判別することができ、3方向に独立して駆動できることを確認した。屈曲機構の内視鏡からの突き出し量は約7mm、内視鏡先端からターゲットまでの距離は約14mmであった。内視鏡の彎曲角を保持した状態で、屈曲機構を作動させ、屈曲機構を回転させた際に約90°までは徐々に屈曲機構シャフト部がねじれ、反対方向へのトルクがかかる感触が感じられたが、ゆっくりと回転させることができた。一方でそれ以上に回転させようとした際は徐々にすべりが悪くなり、その後一度に大きく回転してしまい、トラッカビリティは低かった。同様の実験を突き出し量5mmで行った。スポット位置の移動量は1.5mmほどで、突き出し量7mmの際と同様に十分に移動したが、屈曲機構を最大に屈曲した状態では回転させることは困難であった。

  27. Local internal pressure measurement system of cerebral aneurysm model using ultra-miniature fiber-optic pressure sensor

    Makoto Ohta, Yoichi Haga

    MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science　2018-January　1-3　2018/02/28

    DOI： 10.1109/MHS.2017.8305197 　

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    © 2017 IEEE. Local internal pressure measurement system of cerebral aneurysm model has been developed for the quantitative evaluation of the therapeutic effects of the coil embolization. For local pressure measurement at multi point, an ultra-miniature fiber-optic pressure sensor, of which diameter is 125 μm and measurement system which has four channel optical switch has been developed. In this study, the cerebral aneurysm model equipped with two fiber-optic pressure sensors was fabricated and the pressure measurement of two sensors was performed.

  28. Development of a blood vessel model with ultrasound sensors to quantify intravascular treatment skills

    MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science　2018-January　1-4　2018/02/28

    DOI： 10.1109/MHS.2017.8305199 　

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    © 2017 IEEE. Intravascular surgery using catheters, such as coil embolization and stent placement, is a minimally invasive treatment. However, doctors need to be skillful to perform precise intravascular surgery. It is expected that displacement of the blood vessel wall caused by unexperienced doctor&#039;s manipulation of a guidewire and a catheter is relatively larger and more frequent than that of experienced skillful doctor&#039;s. Although several s intravascular surgery simulators have been developed to obtain the intravascular treatment skills, they cannot evaluate a quantitative difference of skills between unexperienced doctors and experienced skillful doctors. In this study, ultrasound micro sensors mounted on flexible substrates have been fabricated for installing in the blood vessel model locally. Three sensors were located near the blood vessel model and this model was filled with 5-wt% poly vinyl alcohol-hydrogel (PVA-H). This model is useful to measure displacement of the blood vessel wall of the model when the catheter contacts and pushes the blood vessel wall from inside. When the catheter contacted, displacement of blood vessel wall was measured about 150 μm by a fabricated ultrasound sensor. It is expected that this model is useful to evaluate skillfulness of intravascular doctor&#039;s technique and effectiveness of training.

  29. Ultrasound sensors installed in blood vessel model for intravascular surgery procedures

    2017 IEEE International Conference on Cyborg and Bionic Systems, CBS 2017　2018-January　289-292　2018/01/19

    DOI： 10.1109/CBS.2017.8266117 　

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    © 2017 IEEE. Intravascular surgery using catheters is a lesser invasive treatment for vascular disease than conventional surgery procedure. It is necessary for doctors to manipulate a guidewire and a catheter in blood vessel to the targeted diseased area via carotid artery in the case of intravascular surgery in the brain. Though a blood vessel model is useful for training of doctors in the field of the intravascular surgery, evaluations of their skill and efficacy of the training are insufficient. In this study, ultrasound micro sensors mounted on flexible substrates have been fabricated for installing in the blood vessel model locally. The sensor was located near the cerebral blood vessel model to measure displacement of the blood vessel wall of the model and the catheter when the catheter contacts and pushes the blood vessel wall from inside. When delay time of reflected echo signal shifted 0.453 μs, displacement of blood vessel wall was calculated as 0.339 mm. It is expected that the blood vessel model with sensors is useful to evaluate skillfulness of doctor&#039;s technique and effectiveness of training.

  30. Multipoint pressure measurement in blood vessel model for evaluation of intravascular treatment of cerebral aneurysm using fiber-optic pressure sensors

    2017 IEEE International Conference on Cyborg and Bionic Systems, CBS 2017　2018-January　136-139　2018/01/19

    DOI： 10.1109/CBS.2017.8266083 　

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    © 2017 IEEE. In recent years, endovascular coil embolization for cerebral aneurysms has been used as an effective and minimally invasive treatment. However, the therapeutic effects might be deteriorated due to the incorrect positioning of the coils in the aneurysm or insufficient reduction of the blood flow in the neck area of the aneurysm. Therefore, the quantitative evaluation of the therapeutic effects of coil embolization is important. We have developed a system that measures intraaneurysmal pressure in the blood vessel model at multipoint using ultra-miniature fiber-optic pressure sensors. The blood vessel model including aneurysm model is fabricated using Poly (vinyl alcohol) hydrogel (PVA-H). Two ultra-miniature fiber-optic pressure sensors are inserted from outside and placed in the aneurysm area. Two commercially available pressure sensors were also connected to both the upstream and downstream sides of the model. The pressure measurement was performed in the aneurysm and in the adjacent blood vessel. Pressure were measured before and after coil placement in the aneurysm.

  31. バイオデザイン手法による研究開発の設計~誤嚥検出デバイスの開発を目指して~

    原陽介, 原陽介, 香取幸夫, 瀧宏文, 中川敦寛, 芳賀洋一, 永富良一, 出江紳一

    日本嚥下医学会抄録(Web)　41st　2018

  32. Enzyme printed enzyme electrode sensor for low concentration lactate monitoring

    Noriko Tsuruoka, Tadao Matsunaga, Kumi Y. Inoue, Tomokazu Matsue, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　138　(6)　231-240　2018

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.138.231 　

    ISSN：1347-5525 1341-8939

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    In this research, enzyme electrode sensor for measuring low concentration lactate was fabricated. In our previous work, microperfusion needle to measure concentration of lactate in subepidermal tissue have been developed. Using this microperfusion needle, lactate concentration of perfusate was about one percent of lactate concentration of blood. In order to measure this low concentration of lactate, enzyme electrode sensor using printed enzyme was fabricated. Au electrodes were patterned on the glass substrate. Ag nanometal ink was printed on reference electrode. Os-HRP polymer was printed by pasting needle type printer and lactate oxidase was printed by inkjet printer on working electrode. Addition agents which do not inactivate enzymes as wetting agent and viscosity modifier were selected. A flow channel was pasted on fabricated electrodes to measure concentration changes continuously. Fabricated sensor had high sensitivity and could measure low concentration lactate (0.01-0.25 mM). In addition, fabricated sensor was not affected by interfering substances.

  33. Bending mechanism using SMA wires for transurethral lithotripsy

    Toshiki Tachioka, Tadao Matsunaga, Yoshikatsu Tanahashi, Takumi Kobayashi, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　138　(2)　41-47　2018

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.138.41 　

    ISSN：1347-5525 1341-8939

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    In the transurethral lithotripsy using flexible endoscope (f-TUL), a flexible ureteroscope is inserted into the bladder from the urethra and breaks calculus by laser transmitted through an optical fiber. Because laser irradiation position is fixed in the endoscopic field of view, it is difficult to perform precise alignment of laser to the target when the target has relatively complex structure. To solve the problem, a thin multidirectional active bending mechanism of the laser fiber using Shape Memory Alloy (SMA) wire has been developed. This device has 170 μm diameter channel for laser fiber and is controlled by 3 SMA wires. Maximum outer diameter is 1.1 mm and length of the bending part is 10 mm. The fabricated bending mechanism with laser fiber bends up to 10 degrees. Surface temperature was measured by using a thermocouple in water bath and was lower than 41°C.

  34. Enzyme printed enzyme electrode sensor for low concentration lactate monitoring

    34　1-6　2017/10/31

    Publisher: Institute of Electrical Engineers of Japan

  35. 光ファイバを用いた経鼻的下垂体手術用ロボットツール用力覚センサの開発

    新田 達也, 中塚 俊樹, 川端 友徳, 松永 忠雄, 芳賀 洋一, 原田 香奈子, 光石 衛, 荒田 純平

    日本コンピュータ外科学会誌　19　(4)　262-263　2017/10

    Publisher: (一社)日本コンピュータ外科学会

    ISSN：1344-9486

  36. 長尺状の医療器具の保持機構を備えた水中耳科手術用内視鏡システムの開発

    山内 大輔, 松永 忠雄, 本藏 陽平, 原 陽介, 荒川 一弥, 日高 浩史, 川瀬 哲明, 芳賀 洋一, 香取 幸夫

    日本耳鼻咽喉科学会会報　120　(4)　587-587　2017/04

    Publisher: (一社)日本耳鼻咽喉科学会

    ISSN：0030-6622

    eISSN：1883-0854

  37. 人工内耳挿入補助機構を備えた水中耳科手術用内視鏡

    松永 忠雄, 秋山 恭一, 山内 大輔, 川瀬 哲明, 香取 幸夫, 鶴岡 典子, 芳賀 洋一

    日本コンピュータ外科学会誌　19　(2)　74-82　2017/04

    Publisher: (一社)日本コンピュータ外科学会

    ISSN：1344-9486

    eISSN：1884-5770

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    内耳は繊細な器官であるため、内耳にアプローチする手術では細心の注意を払うことが必須となる。例えば、内耳瘻孔の処理の際に瘻孔上で内耳リンパ液を吸引すると、内耳へ空気が侵入して不可逆的な内耳障害をきたす。これを防ぐために通常は生理食塩水を滴下しながら顕微鏡下に処理するが、水面の反射や屈折によって対象物の正確な位置が把握しにくい場合がある。そこで、生理食塩水の浸水下に内視鏡による視野を用いて内耳瘻孔の処理や内耳の開放を行う「水中内視鏡下耳科手術(UWEES)」を考案した。さらに、UWEESによる人工内耳(CI)挿入を片手操作でも容易に施行できるCI挿入補助機構を備えた水中内視鏡を考案・試作した。今回、その有用性について検討するため、灌流量測定などの基本特性評価に加え、側頭骨模型を用いてCI挿入術のシミュレーション評価を行い、補助機構のないコントロールと比較した。結果、CI挿入補助機構を備えた水中内視鏡の有用性が確認された。

  38. Bending mechanism using SMA wires for the transurethral lithotripsy

    33　1-5　2016/10/02

    Publisher: Institute of Electrical Engineers of Japan

  39. 小型発汗計の開発とストレス負荷及び温熱負荷時の発汗計測

    鶴岡 典子, 河野 隆宏, 松永 忠雄, 永富 良一, 芳賀 洋一

    生体医工学　54　(5)　207-216　2016/10

    Publisher: 日本生体医工学会

    ISSN：1347-443X

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    室温21℃、湿度30〜40%の環境下において、既知の水分量を作製したデバイスで計測し、測定誤差や応答時間について評価した。開発した精神性発汗用デバイスは十分な定量評価能を有するものと考えられた。温熱性発汗用デバイスの精度も-4.4±5.6%で、大測定レンジであっても製品発汗計と同等の精度を持つことを確かめた。健康な日本人成人男性12例(22〜25歳)を対象とし、作製したデバイスを用いて精神的ストレスに伴う発汗量の変化を計測した。デバイス装着後全ての被験者において見かけの発汗量が増加し、その後緩やかに基礎発汗量へと収束した。健康な日本人成人男性8例(22〜25歳)を対象とし、作製した温熱性発汗用カプセルレスデバイスを用いて下肢温浴を行った際の発汗量を計測した。デバイス装着直後一時的に発汗量が増加し、5分ほどで定常状態となった。温浴を開始すると、開始後5分ほどで発汗量が増加し始め、下肢温浴開始から20分ほどで値は飽和し始め、ほぼ定量となった。

  40. 人工内耳挿入補助機構を備えた水中耳科手術用内視鏡の開発について

    山内 大輔, 松永 忠雄, 原 陽介, 橋本 研, 太田 淳, 日高 浩史, 川瀬 哲明, 芳賀 洋一, 香取 幸夫

    Otology Japan　26　(4)　308-308　2016/09

    Publisher: (一社)日本耳科学会

    ISSN：0917-2025

    eISSN：1884-1457

  41. CMUT PACKAGING FOR FORWARD LOOKING ULTRASONIC ENDOSCOPE USING LTCC SIDE VIA

    32　1-5　2015/10/28

    Publisher: Institute of Electrical Engineers of Japan

  42. One directional active bending mechanism using shape memory alloy wire for minimally invasive medicine and feedback control by changing in electrical resistance of wire

    Takumi Kobayashi, Tadao Matsunaga, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　135　(10)　393-398　2015/10/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.135.393 　

    ISSN：1347-5525 1341-8939

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    The bending mechanism of a conventional endoscope operates by drawing wires from outside the human body. The shaft structure of endoscopes is relatively complex to avoid buckling caused by wire traction. In this study, one directional bending mechanisms using shape memory alloy (SMA) wires have been developed for minimally invasive medicine. A large bending angle was accomplished by positioning a working point of driven SMA wires near a center point of the mechanism and by surrounding the SMA wires and an inner tube by helical thin metal wire. External diameter and length of the bending part of the mechanism are 4.1 mm and 35 mm respectively. The curvature radius of the fabricated device is 20 mm while maintaining the surface temperature of the device under 41°C in environmental temperature (38°C). Servo control has been considered to be suitable for the application of active bending mechanisms as micro robots. Feedback control by changing in the electrical resistance of the SMA wire was utilized for precise and safty actuation.

  43. 内視鏡手術のための液圧駆動屈曲機構の開発

    須田 信一郎, 小林 拓生, 松尾 美幸, 平良木 貴久, 高橋 恵太, 松永 忠雄, 芳賀 洋一

    日本コンピュータ外科学会誌　17　(2)　83-90　2015/08

    Publisher: (一社)日本コンピュータ外科学会

    DOI： 10.5759/jscas.17.83 　

    ISSN：1344-9486

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    We developed a safe, minimally invasive articulated flexible endoscopic instrument that is actuated by hydraulic pressure. Metal close coiled helical springs, chemically covered in a vapor deposit membrane of evaporated parylene make up the hydraulic pressure actuators. Made from biocompatible materials, the actuators, specifically fabricated for endoscopic tools, hydraulically extend and contract linearly. The lateral side is static and held in place by a thin polyimide tube, when hydraulic pressure is increased to elongate the actuator, causing the corresponding side to bend. Two types of unidirectional articulating endoscopes consisting of multiple bending links were successfully developed, demonstrated, and their functions were confirmed.

  44. Development of low flow rate disposable electrolysis pump for subepidermal microperfusion

    Noriko Tsuruoka, Tadao Matsunaga, Ryoichi Nagatomi, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　135　(8)　330-337　2015/08/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.135.330 　

    ISSN：1347-5525 1341-8939

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    An electrolysis pump was developed for wearable microperfusion system. In our previous work, minimally invasive microperfusion needle which collects biological substances from subepidermal tissue had been developed. The pump for perfusate perfusion of this microperfusion system requires low flow rate, continuous flow, low power consumption and disposability. Electrolysis pump is relatively simple structure and requires low power consumption. Thus, electrolysis pump is suitable for disposable device. Fabricated pump consists of an electrolyte chamber which contains interdigitated array electrodes, a discharge liquid chamber and a Parylene corrugated membrane between the two chambers. The electrolyte chamber is filled with deionized (DI) water. The gases (hydrogen and oxygen) are produced in electrolyte chamber and the liquid is discharged by pushing the corrugated membrane. The fabricated pump had enough function to discharge the discharge liquid at a flow late of less than 5 μl/min for more than 120 minutes. When this pump is used in wearable system, the pump is used in various positions. Hydrogel was added to electrolyte to reduce influence of position changes. This pump had enough function to discharge liquid in required condition at up-side down condition.

  45. Neural probe with multi optical stimulation in depth direction

    Shunsuke Tamaki, Tadao Matsunaga, Toshinobu Kuki, Hajime Mushiake, Yoshihito Furusawa, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　135　(7)　246-252　2015/07/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.135.246 　

    ISSN：1347-5525 1341-8939

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    In this paper, Tube-shaped neural probe which has 8 recording areas and 3 optical emitting points using with optogenetics technique for neural circuit analysis has been developed. Outer diameter of tube is 360 μm, the recording areas and the optical emitting points arranged in a depth direction. The optical emitting points make it possible to stimulate neurons in various depth areas respectively. We demonstrated the recording and stimulating of neurons in vivo experiment. As the result, the probe got light induced neural activities at all the optical emitting points.

  46. Small diameter selective organ perfusion catheter with fiber-optic pressure sensor

    Yuko Tachibana, Tadao Matsunaga, Yoshikatsu Saiki, Yukihiro Hayatsu, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　135　(6)　204-209　2015/06/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.135.204 　

    ISSN：1347-5525 1341-8939

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    A small diameter (O.D. 1.47 mm) selective organ perfusion catheter with fiber-optic pressure sensor for monitoring perfusion pressure has been fabricated. As a design of the tip of the sensor, non-opening type and opening type have been fabricated and the opening design decrease influence by external force such as load or the balloon inflation on catheter down to 1-2 mmHg and achieved error range ±3 mmHg in the pressure measurement range of 0-100 mmHg.

  47. Cup-shaped medication recording device for taking intraoral pictures

    Kenji Ishii, Yoko Kawai, Noriko Tsuruoka, Takahiro Fuse, Taku Obara, Tadao Matsunaga, Yutaka Imai, Yoichi Haga

    IEEJ Transactions on Electronics, Information and Systems　135　(2)　197-203　2015/02/01

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejeiss.135.197 　

    ISSN：1348-8155 0385-4221

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    To improve the reliability of medication record keeping, we have developed a cup-shaped medication recording device and system for taking intraoral pictures of pills. This device has a camera, a memory card with a wireless transmitter, a capacitance sensor, a processing unit, and a rechargeable battery in the cup. When the capacitance sensor used as the trigger switch detects water level change, the camera starts shooting and takes some intraoral pictures. Waterproofing is achieved by the use of wireless data transmission and wireless battery recharging to enable washability of the cup. In the first experiment, ten trials in one subject were conducted. There were 2.6±0.7 pictures per an action of taking pill. The pill was successfully photographed in all trials. Thirteen subjects participated in a second experiment. Intraoral pictures of pills were taken and sent to a PC or a server wirelessly in all subjects. These results show that this device can be expected to reliably record medication, to improve patient adherence, and reduction of medical labor.

  48. Flexible Tube-Shaped Neural Probe for Recording and Optical Stimulation of Neurons at Arbitrary Depths

    Shunsuke Tamaki, Toshinobu Kuki, Tadao Matsunaga, Hajime Mushiake, Yoshihito Furusawa, Yoichi Haga

    SENSORS AND MATERIALS　27　(7)　507-523　2015

    Publisher: MYU, SCIENTIFIC PUBLISHING DIVISION

    DOI： 10.18494/SAM.2015.1087 　

    ISSN：0914-4935

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    Transparent tube-shaped neural probes consisting of 8 recording areas on the surface of a cylinder and a movable optical fiber that is set in a groove of a stainless steel needle at the core have been developed. The recording areas are placed perpendicularly to the brain surface so that neural activities can be recorded across cortical layers. The movable metal needle with optical fiber enables optical stimulation of neurons surrounding the recording areas at any depth in the cortex. The neural probe was fabricated and examined for its applicability in optogenetic studies in neuroscience. The fabricated probe successfully recorded neural activities from the cortex of an anesthetized animal while optical stimulation was delivered successively at any depth of the cortex. Distinct neural activation patterns depending on the depth of optical stimulation were found. It was confirmed that the fabricated probe is suitable for optical manipulation for analysis of neural activities across cortical layers and simultaneously monitoring the effects of stimulation on neural activities.

  49. Development of electrolysis pump for subepidermal microperfusion system

    Noriko Tsuruoka, Tadao Matsunaga, Ryoichi Nagatomi, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　247-O-248　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-247 　

    ISSN：1347-443X 1881-4379

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    Concentrations of biological substances are useful as indicators of physiological and pathological states. In our previous work, minimally invasive microperfusion needle which collects biological substances from subepidermal tissue had been developed. In this study, an electrolysis pump was developed as the pump which perfuses perfusate into microperfusion needle. Electrolysis pump is suitable for our wearable microperfusion system, because it requires simple structure and low power consumption. This pump consists of electrolyte chamber which contains interdigitated array electrodes, discharge liquid (perfusate) chamber and Parylene corrugated membrane between two chambers. When voltage is applied to the electrodes, gases are generated in electrolyte chamber and perfusate is discharged by pushing the corrugated membrane. The fabricated pump had enough function to discharge the discharge liquid at flow late of less than 5 μl/min.

  50. Side viewing add-on endoscope for endoscopic cancer treatment

    Takahisa Hiraragi, Takumi Kobayashi, Miyuki Matsuo, Shinichiro Suda, Tadao Matsunaga, Katsunori Iijima, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　476-O-477　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-476 　

    ISSN：1347-443X 1881-4379

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    In this study, side viewing endoscope has been developed for cancer therapy. Polypectomy is a technique for treatment of early cancer and polyp in the gut. Endoscope can not observe backside of the lesion, because only front viewing is available. This device is available to add on for endoscope to observe the backside of the lesion. The device consists of a CMOS imager, two LEDs and a mirror to observe side view in front of CMOS imager. This device has hydraulic actuator or shape memory alloy (SMA) wire as bending mechanism. The external diameter of fabricated devices is 2.5 mm. The fabricated side viewing endoscope achieved to observe the backside of the lesion in the stomach model.

  51. Development of cylinder shape probe for myocardial hardness measurement during heart surgery

    Tsubasa Matsumoto, Tadao Matsunaga, Shintaro Katahira, Yoshikatsu Saiki, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　448　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-448 　

    ISSN：1347-443X 1881-4379

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    In heart surgery with extracorporeal circulation machine, myocardium becomes hard when myocardial preservation is not appropriate. Myocardial hardness measurement probe has been developed for quantitative hardness monitoring measurement for myocardial preservation. To measure myocardial hardness negative pressure is applied to the myocardium through the probe and displacement of myocardial surface is measured using ultrasonic pulse-echo. Using two silicone rubbers which have different hardness, we applied the same strength negative pressure to their surfaces. We measured the displacement of two silicone rubbers.

  52. Small diameter electromagnetic single fiber endoscope using magnetic material tube and assist coil

    Xuan Li, Tadao Matsnuaga, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　495　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-495 　

    ISSN：1347-443X 1881-4379

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    The purpose of this study is to develop a small diameter (less than 1 mm) and high resolution endoscope. This probe consists of single optical fiber which is fixed a Ni tube and photo-fabricated metal saddle-shaped coils and solenoid coil which is fabricated by coiling machine. The optical fiber which is fixed a Ni tube is inserted into coil. When an alternating current supplies to the driving coils, the Ni tube is vibrated by magnetic force one dimensionally. With the assist of the magnetic force by additional solenoid shaped assist coils which are located in frontside and backside of the saddle-shaped coil, the vibration amplitude of the fiber is increased. The 1 mm diameter probe has been fabricated, and fiber vibration amplitude increase was confirmed.

  53. Development of active bending electric endoscope using shape memory alloy wire

    Takumi Kobayashi, Tadao Matsunaga, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　104　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-104 　

    ISSN：1347-443X 1881-4379

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    A bending mechanism of conventional endoscope bends by traction of wires from outside the human body. A shaft structure of endoscope is relatively complex to avoid buckling by wire traction force. An active bending electric endoscope has been developed using SMA (shape memory alloy) wires. The SMA wires are driven by Joule heat provided electrical current to the wire. The active bending mechanism using SMA wires simplify bending mechanism of endoscope. A commercial CMOS imager and three LEDs at the tip of this device were mounted and a silicon rubber tube was connected the active bending mechanism using SMA wires as the shaft. This device accomplished multidirectional bending and the curvature radius was approximately 40 mm at 300 mA.

  54. Development of implantable micropump using ultrasound irradiation from outside the human body

    Tsubasa Matsumoto, Yuzuru Chikada, Shinichiro Suda, Tadao Matsunaga, Hiroshi Wada, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　534　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-534 　

    ISSN：1347-443X 1881-4379

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    An implantable micropump without electronic drive parts and has simple structures for local drug delivery has been developed. The device is designed and fabricated for drug application into cochlea at inner ear. An acoustic streaming generated by an ultrasound in a drug solution is used as the driving force. The acoustic streaming was performed by using the device and the generation of the acoustic streaming was confirmed. A magnetic valve was fabricated for prevention of drug misadministration or adverse current and the evaluation was performed. The physical and mental burdens of patients is expected to be decreased by the system.

  55. Hydraulic transformable hood for ESD

    Miyuki Matsuo, Shinichiro Suda, Hiroshi Saito, Tadao Matsunaga, Yoichi Haga

    Transactions of Japanese Society for Medical and Biological Engineering　52　102-O-103　2014/08/17

    Publisher: Japan Soc. of Med. Electronics and Biol. Engineering

    DOI： 10.11239/jsmbe.52.O-102 　

    ISSN：1347-443X 1881-4379

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    A hydraulic transformable endoscopic hood for endoscopic surgery has been developed. The device can be attached at the tip of an endoscope to assist physicians operating endoscopic submucosal dissection (ESD), which is an operation for removing lesions in digestive organs. This device can provide large field of view and ease the process of inserting the tip of an endoscope into incisions as well. We developed a transformable hood using hydraulic actuators. The hydraulic actuator consists of biocompatible Parylene membrane and stainless steel coil. The tip of the hood is divided into three parts. The tip parts open when pressure is applied to the hood, thus expanding the tip radius of the hood. By changing the applied pressure, the tip radius ranged from 4.5 mm to 11.5 mm. When the tip diameter was fixed to 16 mm, the maximum force generated by the hood was 123 mN.

  56. Microsystems for Minimally Invasive Medicine and Healthcare

    Yoichi Haga, Tadao Matsunaga

    2014 INTERNATIONAL CONFERENCE ON ELECTRONICS PACKAGING (ICEP)　353-356　2014

    Publisher: IEEE

    DOI： 10.1109/ICEP.2014.6826710 　

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    Endoscopes and catheters are already widely used and new more precise examinations and diagnoses are required. Small medical devices with several functions for use in the human body can be realized by installing microsensors and microactuators in the medical devices. Several microdevices for minimally invasive examinations and therapies using MEMS (Micro Electro Mechanical Systems) and related microfabrication technologies have been developed. An ultraminiature pressure sensor, a forward-looking intravascular ultrasonic imager and intraluminal MRI probe have been developed. Active bending catheters, endoscopes and guide wires have been developed for steering their tips without using traction of wires from outside the body. Small and light wearable healthcare devices have also been developed using the microfabrication technologies.

  57. Capacitive micromacliiiied ultrasonic transducers using anodically bondable ceramic wafer with through-wafer via

    Misaki Hiroshima, Tadao Matsunaga, Takashi Mineta, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　134　(10)　333-337　2014

    Publisher: Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejsmas.134.333 　

    ISSN：1347-5525 1341-8939

    eISSN：1347-5525

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    Tins paper desenbes the design and experimental results of C'MUTs (Capacitive Mieromachined Ultrasonic Transducers) using an anodically bondable LTCC (Low Temperature C'o-fired Ceramics) wafer. Electrical connection of the C'MUTs top electrode and the LTCC via were successfully performed at a tune of anodic bondmg by forming Au bump on the electrode. The vibration characteristics of the membrane were measured by a laser Doppler \\ibrometer both in the atmosphere and in the water. Ultrasonic pressure signal of CMUTs arrays was measured using hydrophone.

  58. MEMS技術を利用した低侵襲医療・ヘルスケア機器の開発

    芳賀洋一, 松永忠雄

    日本機械学会誌　116　(1130)　32-36　2013

    Publisher: The Japan Society of Mechanical Engineers

    ISSN：0021-4728

  59. 医療用マイクロ化学センサ(ヘッドライン:医療現場を支える化学)

    芳賀 洋一

    化学と教育　61　(11)　526-529　2013

    Publisher: 公益社団法人 日本化学会

    DOI： 10.20665/kakyoshi.61.11_526 　

    ISSN：0386-2151

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    半導体などに用いられる微細加工技術によって,小さく高機能なマイクロ化学センサが実現し,用いられている。小型(マイクロ)である利点を活かした生体計測について,検体計測,体内計測,および体表におけるウェアラブル体外計測に分けて,実例を紹介しながら代表的なマイクロ化学センサの種類とその動作原理を述べる。また,新たな手法として核磁気共鳴(NMR)計測,ゲルの体積変化を利用した生体成分計測,皮下に留置する微細加工を用いた流路付き微小針についても述べる。

  60. Development of Minimally Invasive Medical Tools Using Laser Processing on Cylindrical Substrates

    Yoichi Haga, Yuta Muyari, Shoji Goto, Tadao Matsunaga, Masayoshi Esashi

    ELECTRICAL ENGINEERING IN JAPAN　176　(1)　65-74　2011/07

    Publisher: WILEY-BLACKWELL

    DOI： 10.1002/eej.21030 　

    ISSN：0424-7760

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    This paper reports micro-fabrication techniques using laser processing on cylindrical substrates for the realization of high-performance multifunctional minimally invasive medical tools of small size. A spring-shaped shape memory alloy (SMA) micro-coil with a square cross-section has been fabricated by spiral cutting of a Ti-Ni SMA tube with a femtosecond laser. A small-diameter active bending catheter actuated by a hydraulic suction mechanism for intravascular minimally invasive diagnostics and therapy has also been developed. The catheter is made of Ti-Ni superelastic alloy (SEA), which is processed by laser micromachining, and a silicone rubber tube that covers the outside of the SEA tube. The active catheter is effective for insertion into branches of blood vessels that diverge at acute angles where it is difficult to proceed. Multilayer metallization and patterning have been performed on glass tubes with 2- and 3-mm external diameters using maskless lithography techniques with a laser exposure system. Using the laser soldering technique, integrated circuit parts have been mounted on a multilayer circuit patterned on a glass tube. These fabrication techniques will be effective for the realization of high-performance multifunctional catheters, endoscopic tools, and implanted small capsules. (c) 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(1): 65-74, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21030

  61. 微細加工技術と光ファイバー技術を用いた低侵襲医療機器の開発

    芳賀洋一, 松永忠雄, 江刺正喜

    日本レーザー医学会誌　Vol.31　(4)　428-434　2011/01/31

    Publisher: Japan Society for Laser Surgery and Medicine

    DOI： 10.2530/jslsm.31.428 　

    ISSN：0288-6200

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    Development of minimally invasive medical devices using microfabrication techniques and optical fiber technology have been described. Microfabricaion, polymer coating and mounting micro mechanical structures at the optical fiber end have been performed and mentioned. Development of laser therapeutic tool with movable mirror and thin endoscope with electromagnetic solenoid coil using microfabrication technique and equipment have been mentioned. It is expected that these fabrication techniques and microdevices can enlarge possibility of optical fiber application for minimally invasive medicine.

  62. Development of active bending electric endoscope using shape memory alloy for disposable and thin endoscope

    Wataru Makishi, Masaharu Ikeda, Masayoshi Esashi, Tadao Matsunaga, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　131　(3)　1-110　2011

    DOI： 10.1541/ieejsmas.131.102 　

    ISSN：1341-8939 1347-5525

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    Bending motions of the tip of a conventional endoscope are controlled from outside the body by wire traction. A shaft of an endoscope should be relatively hard to avoid buckling by wire traction. The active bending mechanism of an endoscope, which is realized using shape memory alloy (SMA) coil actuators instead of wire traction, is soft. Using micro-fabrication technology on non-planar substrate, cylindrical substrate of thin endoscope was fabricated. These endoscopes enable precise observations and treatments of deep areas of the human body. © 2011 The Institute of Electrical Engineers of Japan.

  63. 光MEMS技術を用いた低侵襲医療デバイス

    芳賀洋一

    OPTRONICS　No.7(通巻No.343)　115-118　2010/07/10

  64. 光マイクロスキャナーの低侵襲医療への応用

    芳賀洋一, 松永忠雄, 江刺正喜

    O plus E　(5)　554-559　2010/04/28

  65. マイクロマシニング・MEMS技術を用いた低侵襲医療機器の開発

    芳賀洋一, 松永忠雄, 江刺正喜

    塑性と加工　Vol.51　(No.590)　209-213　2010/03/25

    DOI： 10.9773/sosei.51.209 　

  66. マイクロマシニング・MEMSを用いた低侵襲医療機器の開発

    芳賀洋一, 松永忠雄, 江刺正喜

    塑性と加工　Vol.51　(No.590)　209-213　2010/03/25

    DOI： 10.9773/sosei.51.209 　

  67. 講座 ちょっとMEMS 第18回 体内で用いる医療デバイスの高機能化・多機能化

    芳賀洋一

    エレクトロニクス実装学会誌　Vol.13　(No.2(通巻85号))　156-162　2010/03/01

    DOI： 10.5104/jiep.13.156 　

  68. High-functionalization and multi-functionalization of medical devices for use in human body properties and fabrication technologies required by medical devices for use in human body

    Yoichi Haga

    Journal of Japan Institute of Electronics Packaging　13　(2)　156-162　2010/03

    DOI： 10.5104/jiep.13.156 　

    ISSN：1343-9677 1884-121X

  69. 0817 Development of micro devices for advanced minimally invasive treatment

    MATSUNAGA Tadao, HAGA Yoichi

    2009　(22)　141-141　2010/01/08

    Publisher: The Japan Society of Mechanical Engineers

  70. 講座 ちょっとMEMS 第17回 体内で用いる医療デバイスの高機能化・多機能化

    芳賀洋一

    エレクトロニクス実装学会誌　Vol.12　(No.7(通巻83号))　156-162　2009/11

  71. High-functionalization and multi-functionalization of medical devices for use in human body implantable devices

    Yoichi Haga

    Journal of Japan Institute of Electronics Packaging　12　(7)　651-656　2009/11

    DOI： 10.5104/jiep.12.651 　

    ISSN：1343-9677

  72. 体内で用いる医療デバイスの高機能化・多機能化

    芳賀洋一

    エレクトロニクス実装学会誌　Vol.12　(No.6)　557-560　2009/09/01

    DOI： 10.5104/jiep.12.557 　

  73. High-functionalization and multi-functionalization of medical devices for use in human body minimally invasive diagnostic and therapeutic devices

    Yoichi Haga

    Journal of Japan Institute of Electronics Packaging　12　(6)　557-560　2009/09

    DOI： 10.5104/jiep.12.557 　

    ISSN：1343-9677

  74. 光ファイバーを用いた低侵襲医療用マイクロデバイス

    芳賀洋一, 松永忠雄, 小野崇人, 江刺正喜

    NEW GLASS　Vol.24　(No.1)　28-34　2009/03/01

  75. A high-resolution endoscope of small diameter using electromagnetically vibration of single fiber

    Tadao Matsunaga, Ryunosuke Hino, Wataru Makishi, Masayoshi Esashi, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　129　(11)　5-404　2009

    DOI： 10.1541/ieejsmas.129.399 　

    ISSN：1341-8939 1347-5525

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    For high resolution visual inspection in the narrow space of the human body, small diameter endoscope has been developed which utilize electromagnetically vibration of single fiber. Thin endoscopes are effective for inspection in the narrow space of the human body, for example, in the blood vessel, lactiferous duct for detection infiltration of breast cancer, and periodontal gap between gingiva and tooth. This endoscope consists of single optical fiber and photofabricated driving coils. A collimator lens and a cylindrical permanent magnet are fixed on the optical fiber, and the tilted driving coils have been patterned on a 1.08 mm outer diameter thin tube. The fiber is positioned at the center of the tube which is patterned the coils. When an electrical alternating current at the resonance frequency is supplied to the coils, the permanent magnet which is fixed to the fiber is vibrated electromagnetically and scanned one or two dimensionally. This paper reports small diameter endoscope by using electromagnetically vibration of single fiber. Optical coherence tomography imaging has also been carried out with the fabricated endoscope and cross-section image of sub-surface skin of thumb was observed. © 2009 The Institute of Electrical Engineers of Japan.

  76. マイクロ・ナノマシニング技術を用いた低侵襲医療機器の開発

    芳賀洋一, 松永忠雄, 江刺正喜

    精密工学会誌　Vol.74　(No.11)　1139-1142　2008/11/05

    Publisher: The Japan Society for Precision Engineering

    DOI： 10.2493/jjspe.74.1139 　

    ISSN：0912-0289

  77. MEMS技術を用いた医療デバイス

    芳賀洋一

    光技術コンタクト　Vol.46　(No.5)　216-221　2008/05/20

  78. マイクロ / ナノテクノロジーを用いた超精密低侵襲検査・治療機器の開発

    芳賀洋一, 松永忠雄, 牧志 渉

    TUBERO Bulletin Final　53-56　2008/02/08

  79. Development of minimally invasive medical devices using micro/nano machining technology

    Seimitsu Kogaku Kaishi/Journal of the Japan Society for Precision Engineering　74　1139-1142　2008/01/01

    DOI： 10.2493/jjspe.74.1139 　

    ISSN：0912-0289

  80. Development of intravascular MRI probe applicable to catheter mounting

    Shoji Goto, Tadao Matsunaga, Yuichiro Matsuoka, Kagayaki Kuroda, Masayoshi Esashi, Yoichi Haga

    IEEJ Transactions on Sensors and Micromachines　128　(10)　4-395　2008

    DOI： 10.1541/ieejsmas.128.389 　

    ISSN：1341-8939 1347-5525

    eISSN：1347-5525

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    This paper reports the concept and fabrication techniques of high-resolution intravascular magnetic resonance imaging (MRI) probes. A receiver coil placed in the luminal tissues such as vessels may sensitively detect the signal from the surrounding tissue to produce high-resolution intravascular images. The intravascular MRI offers great potential for in vivo diagnosis of vascular diseases, therapeutic planning, and therapeutic effect evaluation. An ideal intravascular receiver coil should have homogeneous and high signal-to-noise ratio around the coil, tightly placed tuning/matching circuits, and a large working channel for a medical device such as a catheter used as a substrate. In this study, multilayer and/or three-dimensional photolithography techniques were used for fabricating a receiver coil on cylindrical substrates. A coil has been fabricated on a glass capillary with 2 mm outer diameter. The coil was connected to tuning/matching capacitors and decoupling pin-diodes. Imaging of a vessel wall and a phantom with 2-mm pitch acrylic lattice were performed on a 1.5-T MRI scanner resulting in 7.5-mm imaging region. The probe coil was then applied to a vessel wall sample resected from a porcine subclavian artery. The results successfully demonstrated the usefulness of the probe coil for high-resolution intravascular imaging. © 2008 The Institute of Electrical Engineers of Japan.

  81. Development of minimally invasive medical tools using laser processing on cylindrical substrates

    Yoichi Haga, Yuta Muyari, Shoji Goto, Tadao Matsunaga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　128　(10)　6-409　2008

    DOI： 10.1541/ieejsmas.128.402 　

    ISSN：1341-8939 1347-5525

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    This paper reports micro-fabrication techniques using laser processing on cylindrical substrates for the realization of high-performance multifunctional minimally invasive medical tools with small sizes. A spring-shaped shape memory alloy (SMA) micro-coil with a square cross section has been fabricated by spiral cutting of a Ti-Ni SMA tube with a femtosecond laser. Small diameter active bending catheter which is actuated by hydraulic suction mechanism for intravascular minimally invasive diagnostics and therapy has also been developed. The catheter is made of a Ti-Ni super elastic alloy (SEA) tube which is processed by laser micromachining and a silicone rubber tube which covers the outside of the SEA tube. The active catheter is effective for insertion in branch of blood vessel which diverse in acute angle which is difficult to proceed. Multilayer metallization and patterning have been performed on glass tubes with 2 and 3 mm external diameters using maskless lithography techniques using a laser exposure system. Using laser soldering technique, a integrated circuit parts have been mounted on a multilayer circuit patterned on a glass tube. These fabrication techniques will effective for realization of high-performance multifunctional catheters, endoscopic tools, and implanted small capsules. © 2008 The Institute of Electrical Engineers of Japan.

  82. Development of high-resolution intraluminal and intravascular MRI probe using microfabrication on cylindrical substrates

    Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)　329-332　2007/12/01

    ISSN：1084-6999

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    The objective of this study is development of high-resolution intraluminal and intravascular MRI probe using microfabrication on cylindrical substrates. MRI holds promise for in vivo characterization due to its potential for obtaining high-resolution images and its sensitivity to the compositional characteristics of lesion. By placing a receive coil in the human body, NMR signals from the tissue surrounding the coil can be detected sensitively and the method enables in vivo high-resolution imaging (high spatial resolution and high spectroscopic resolution). The preferable receive coil has homogeneous RF receptivity around the probe and high-SNR. Novel coil designs and/or multi-coil have capabilities to meet these demands. To connect the tuning/matching circuit and amplifier circuit near the coil is needed to improve SNR of the system. Microfabrication on cylindrical substrate is one of methods for fabricating arbitrary coil pattern and the tuning/matching circuit on the tube with small diameters. Using a maskless lithography technique, solenoid coil, tilted coil and saddle shaped coil have been fabricated on glass tube with 2 mm O.D.. Imaging test of the coils were performed on 3 T MRI in a 2 % agar phantom. ©2007 IEEE.

  83. 医療用マイクロロボット

    芳賀洋一, 松永忠雄, 牧志 渉, 江刺正喜

    ロボット　No.178　1-6　2007/09/20

  84. 安全安心をめざす，医療機器へのマイクロシステムの応用

    芳賀洋一, 松永忠雄, 牧志 渉, 江刺正喜

    エレクトロニクス実装学会誌　Vol.10　(No.6)　453-456　2007/09/01

    DOI： 10.5104/jiep.10.453 　

  85. Development of Intravascular Forword-looking Ultrasound Imaging probe

    CHEN Jiun-Jie, ESASHI Masayoshi, HAGA Yoichi

    2007　(7)　73-76　2007/07/02

  86. 低侵襲検査・治療のための超音波マイクロデバイスの開発 ＝体の内側から超音波で見る、治す＝

    芳賀洋一, 陳 俊傑, 安居晃啓, 和田 仁, 江刺正喜

    超音波TECHNO　Vol.19　(No.4(通巻187号))　82-86　2007/07/02

    Publisher: 日本工業出版

    ISSN：0916-2410

  87. Endoscopic therapeutic device using focused ultrasonic small transducer

    IEEJ Transactions on Sensors and Micromachines　127　2007/03/15

    ISSN：1341-8939

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    In this research, an ultrasonic probe (5.5 mm in diameter), which has a concave PZT transducer at its tip, was fabricated for ultrasonic treatments such as sonoporation and sonodynatnic therapy in the human body using a catheter and/or endoscope. Ultrasound has the potential to enhance cytotoxicity of drugs such as porphyrins, a process referred to as sonodynamic therapy, and also to deliver macromolecules such as plasmid DNA, a process referred to as sonoporation. The fabricated probe was then experimentally characterized by measuring the acoustic intensity distribution around the focal point, using a PVDF needle-type ultrasonic hydrophone. When the PZT transducer was driven by a 120 Volts peak-to-peak AC signal at 1.83 MHz, the ultrasound output was successfully focused at the focal point, with a peak intensity of 24.9 W/cm 2 (0.87 MPa). Using the fabricated probe, cultured Chinese Hamster Ovary (CHO) cells were exposed to ultrasound (1.83 MHz, continuous wave, peak acoustic pressure of 0.5 MPa) for 2 s in the presence of microbubbles MB-3 and Green Fluorescent Protein (GFP) plasmid DNA. As a result of sonication, the expression of GFP was observed in CHO cells.

  88. Active bending electric endoscope usine shape memory alloy coil actuators

    IEEJ Transactions on Sensors and Micromachines　127　2007/03/15

    ISSN：1341-8939

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    Bending motions of the tip of a conventional endoscope are controlled from outside the body by wire traction. A shaft of an endoscope should be relatively hard to avoid buckling by wire traction. Therefore, precise operation of the endoscope is difficult in complex shape areas such as the intestine. Furthermore, patients suffer pain during a procedure with an endoscope. An active bending electric endoscope using shape memory alloy (SMA) actuators has been developed. A CCD camera (410,000 pixels) is mounted at the end of the endoscope and the tip has an omni-directional bending mechanism using three SMA coil actuators. The SMA coil actuators contract by supplying electrical current and bend the endoscope. The external diameter of the fabricated endoscope is 5.5 mm. The maximum bending angle of the fabricated endoscope is 90° (Curvature radius: 29 mm). The observation of the inside of a blood vessel model by the CCD imager of a fabricated endoscope was confirmed. The active bending shaft of the fabricated endoscope, which is realized using SMA coil actuators instead of wire traction, is soft. Therefore, using this endoscope, it may be possible to perform precise observations and treatment of deep areas of the human body.

  89. Medical Applications of Microsystems Aiming for Safety and Security

    Yoichi Haga, Tadao Matsunaga, Wataru Makishi, Masayoshi Esashi

    Journal of Japan Institute of Electronics Packaging　10　(6)　453-456　2007

    Publisher: 一般社団法人エレクトロニクス実装学会

    DOI： 10.5104/jiep.10.453 　

    ISSN：1884-121X 1343-9677

  90. Active bending electric endoscope using shape memory alloy coil actuators

    Proceedings of the First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006, BioRob 2006　2006　217-219　2006/12/22

    DOI： 10.1109/BIOROB.2006.1639088 　

    More details Close

    Bending motions of the tip of a conventional endoscope are controlled from outside the body by wire traction. A shaft of an endoscope should be relatively hard to avoid buckling by wire traction. Therefore, precise operation of the endoscope is difficult in complex shape areas such as the intestine. Furthermore, patients suffer pain during a procedure with an endoscope. An active bending electric endoscope using shape memory alloy(SMA) actuators has been fabricated. A CCD imager (410,000 pixels) is mounted at the end of the endoscope, and the tip has an omni-directional bending mechanism using three SMA coil actuators. The SMA coil actuators contract by supplying electrical current and bend the endoscope. The bending mechanism is controlled by a joystick from outside the body. The external diameter of the fabricated endoscope is 5.5 mm. The maximum bending angle of the fabricated endoscope is 90° (Curvature radius: 29 mm). The observation of the inside of a blood vessel model by the CCD imager of a fabricated endoscope is confirmed, The shaft of the fabricated endoscope, which is realized using SMA coil actuators instead of a traction wire, is soft. Therefore, the precise observation of a deep area of the small intestine with the fabricated endoscope might be possible without the patient suffering pain.

  91. 26.CCDカメラを搭載した能動カテーテル(平成17年度東北支部大会抄録)

    牧志 渉, 松永 忠雄, 江刺 正喜, 芳賀 洋一

    生体医工学 : 日本エム・イー学会誌　44　(2)　321-321　2006/06/10

    Publisher: 社団法人日本生体医工学会

    ISSN：1347-443X

  92. 25.形状記憶合金コイルと多段階磁気ラッチを用いた3次元ピンディスプレイの開発(平成17年度東北支部大会抄録)

    松永 忠雄, 牧志 渉, 江刺 正喜, 芳賀 洋一

    生体医工学 : 日本エム・イー学会誌　44　(2)　320-321　2006/06/10

    Publisher: 社団法人日本生体医工学会

    ISSN：1347-443X

  93. 精密微細加工技術を用いた高機能低侵襲医療デバイスの開発 (砥粒加工学会誌)

    芳賀洋一, 松永忠雄, 牧志 渉, 戸津健太郎, 峯田 貴, 江刺正喜

    砥粒加工学会誌　50　(5)　245-248　2006/05

  94. 615 Piezoelectric 2D Microscanner for Endoscopic Laser Treatment

    AKAHORI Hiromasa, HAGA Yoichi, MATSUNAGA Tadao, ISEKI Hiroshi, ESASHI Masayoshi, WADA Hiroshi

    2005　(18)　407-408　2006/01/12

    Publisher: The Japan Society of Mechanical Engineers

  95. 536 Development of Focused Ultrasonic Transducer for Treatment in the Human Body

    YASUI Akihiro, HAGA Yoichi, CHEN J. J., ISEKI Hiroshi, ESASHI Masayoshi, WADA Hiroshi

    2005　(18)　371-372　2006/01/12

    Publisher: The Japan Society of Mechanical Engineers

  96. 2B2-01 Assistive input device for ALS patients using an Eddy current displacement sensor

    Murakawa Yoshinobu, Abe Tetsuya, Makishi Wataru, Sakatsume Sinichi, Haga Yoichi

    The JSME Symposium on Welfare Engineering　113-115　2006

    Publisher: The Japan Society of Mechanical Engineers

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    We developed an input support device for amyotrophic lateral sclerosis (ALS) patients. This device senses slight movement of the corners of the mouth or the forehead of an ALS patient with a sensor and functions as an ON/OFF switch. We used a small eddy current displacement sensor for the device. We fix one end of a magnetic material rod of about 30mm in length at the corners of the mouth and fix a sensor on the area of a face which does not move. Another end of the rod is inserted in the cylindrical sensor. A fine adjustment will be easily realized, and it is expected that patients can use it easily even if conditions are worse because of the structure that is hard to be affected by attachment position and angle of the sensor.

  97. Dynamic pindisplay with arrayed pin for blind aid using micro actuators

    T. Matsunaga, W. Makishi, Y. Haga

    IDW '06: PROCEEDINGS OF THE 13TH INTERNATIONAL DISPLAY WORKSHOPS, VOLS 1-3　2　1591-1594　2006

    Publisher: INST IMAGE INFORMATION & TELEVISION ENGINEERS

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    Tactile pindisplay for blind aid and three dimensional pindisplay using Shape Memory Alloy micro actuators has been fabricated and developed. Character and graphic information are dynamically displayed by making pins array up and down. Magnetic material tube is attached to each pin and a permanent magnet fixes position of the pins up or down state. The mechanism solves problems of heat storage and electrical consumption of the SMA actuator because the current is supplied only when the pins move.

  98. Hermitically sealed ultra-miniature fiber-optic pressure sensor

    S. Nakamura, T. Matsunaga, K. Totsu, M. Esashi, Y. Haga

    IDW '06: PROCEEDINGS OF THE 13TH INTERNATIONAL DISPLAY WORKSHOPS, VOLS 1-3　2　1553-1556　2006

    Publisher: INST IMAGE INFORMATION & TELEVISION ENGINEERS

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    Ultra-Miniature fiber optic sensor of 125 mu m diameter has been developed by using MEMS fabrication techniques. The Fabry-Perot cavity is formed at the end of an optical fiber. The pressure induced deformation of the Fabry-Perot cavity diaphragm alters the cavity length. Fabricated sensor structures exhibited temperature dependency. To solve this problem, hermetic sealing using a thin-film solder bonding and Cr thin-film deposition on the sidewall of the sensor have been tried.

  99. Active Bending Electric Endoscope Using Shape Memory Alloy

    MAKISHI W., MATUNAGA T., ESASHI M., HAGA Y.

    7　(3)　329-330　2005/12/30

    ISSN：1344-9486

  100. ナノテクノロジー(ナノメディシン) (人工臓器)

    芳賀洋一

    人工臓器　34　(3)　206-209　2005/12

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.34.206 　

    ISSN：0300-0818

  101. Small diameter ultrasound imager for intraluminal forward-looking inspection

    Proceedings of IEEE Sensors　2005　920-923　2005/12/01

    DOI： 10.1109/ICSENS.2005.1597850 　

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    An intraluminal forward-looking ultrasound probe of 3 mm in diameter has been developed. We used the probe as transmitters and receivers to make ultrasound forward-looking and three-dimensional images, but many artifacts are observed because of strong directivity of the probe. For decreasing the directivity of the probe, a convex-shaped 1-3composite PZT transducer which is 0.7 mm in diameter and 0.75 mm curvature radius was fabricated, and low directivity feature was confirmed. A probe which has eight separated 13composite convex-shaped transducers is fabricated. The probe is 3 mm in diameter and a working channel is 0.5 mm in diameter. Acoustic pressure is measured using a hydrophone which is located 10 mm in front of the probe. The emitting acoustic pressure of 43 Pascal is realized with the fabricated probe. When the probe is used as transmitters and receivers, image of an aluminum rod is constructed. © 2005 IEEE.

  102. Development of the pulsation device for rotary blood pumps

    T Yambe, Y Shiraishi, K Sekine, M Shibata, T Yamaguchi, LH Jian, M Yoshizawa, A Tanaka, H Matsuki, F Sato, Y Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, S Nitta

    ARTIFICIAL ORGANS　29　(11)　912-915　2005/11

    Publisher: BLACKWELL PUBLISHING

    DOI： 10.1111/j.1525-1594.2005.00159.x 　

    ISSN：0160-564X

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    A rotary blood pump ( RP) is desirable as a small ventricular assist device (VAD). However, an RP is non-pulsatile. We tried to develop a device that attaches a pulse to the RP. We also tried to develop a pulse-generating equipment that was not air-pressure driven. The ball screw motor was considered a candidate. The application of a small-sized shape memory alloy was also attempted. An electrohydraulic system was adopted, and actuator power was connected to the diaphragm. The diaphragm was placed on the outer side of the ventricle. Most RPs that have been developed all over the world drain blood from the ventricle. The wave of a pulse should be generated if a pulse is added by the drawn part. The output assistance from the outer side of the ventricle was attempted in animal experiments, and the device operated effectively. This device can be used during implantable operation of RP. This may serve as an effective device in patients experiencing problems in peripheral circulation and in the function of internal organs.

  103. Tube shape piezoelectric 2D microscanner for minimally invasive laser treatment

    Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)　76-79　2005/10/25

    ISSN：1084-6999

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    For precise laser treatment in the human body, a 2D (two dimensional) laser scanning micro tool has been developed. The tool is made up of an optical fiber, a micro rod lens and a 2D microscanner. The 2D microscanner has three piezoelectric unimorph cantilevers that have a ball joint at each tip and a mirror. The mirror is supported by a pivot from underside and is inclined by pushing down by three cantilevers on the top of the mirror. The maximum inclined angle of the mirror is about 26 degrees. For insertion the tool into a working channel of a conventional endoscope, these components are packaged into a 3.8-mm-external-diameter polymer tube. © 2005 IEEE.

  104. 04. 形状記憶合金と磁気ラッチを用いた多段階リニアアクチュエータ(平成16年度東北支部大会抄録, 支部大会抄録)

    櫻井 正博, 松永 忠雄, Bhuiyan M.M.I., 芳賀 洋一

    生体医工学 : 日本エム・イー学会誌　43　(2)　328-328　2005/06/10

    Publisher: 社団法人日本生体医工学会

    ISSN：1347-443X

  105. ナノバイオマテリアルを応用した人工食道の開発 (G．I Research)

    山家智之, 堀, 義生, 渡辺, 誠, 白石泰之, 井ロ篤志, 田林胱一, 芳賀洋一, 江刺正喜, 吉澤 誠, 田中, 明, 松木英敏, 佐藤文博, 川野恭之, 羅 雲, 高木敏行, 早瀬敏幸, 圓山重直, 仁田新一, 佐々田比呂志, 佐藤英明, 本間, 大 前田 剛

    G．I Research　13　(4)　19(271)-24(276)　2005/04

  106. ナノテクノロジーでやさしい医療 --マイクロ・ナノ技術による医用デバイスの開発-- (ビオフィリア)

    芳賀洋一, 江刺正喜

    ビオフィリア　1　(3)　35-42　2005/04

  107. 低侵襲検査・治療のためのマイクロ・ナノマシニング技術 (先端加工技術)

    芳賀洋一

    先端加工技術　65　8-11　2005/03

  108. Focused ultrasonic transducer for localized sonodynamic therapy

    A Yasui, Y Haga, JJ Chen, M Esashi, H Wada

    Transducers '05, Digest of Technical Papers, Vols 1 and 2　2　1660-1663　2005

    Publisher: IEEE

    DOI： 10.1109/SENSOR.2005.1497408 　

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    The aim of this study is to develop the focused ultrasonic transducers using a concave-shaped PZT for localized sonodynamic therapy in the human body. The concave-shaped PZT was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that the ultrasound emitted from the focused ultrasonic transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.

  109. 2-D and 3-D tactile pin display using SMA micro-coil actuator and magnetic latch

    T Matsunaga, W Makishi, K Totsu, M Esashi, Y Haga

    TRANSDUCERS '05, DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2　1　325-328　2005

    Publisher: IEEE

    DOI： 10.1109/SENSOR.2005.1496422 　

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    2-D and 3-D tactile pin display has been fabricated and developed. Character and graphic information are dynamically displayed by making pins array up and down. Shape Memory Alloy (SMA) micro-coil actuators contract and make the pins up and down when the SMA actuator is heated by supplying electrical current. Magnetic material tube is attached to each pin and a permanent magnet fixes position of the pins up or down state. The mechanism solves problems of heat storage and electrical consumption of the SMA actuator because the current is supplied only when the pins move. A 2-D tactile pin display which has 100 (10 x 10) pins array has been developed and successfully operated. The tactile information are displayed sequentially every 0.3 sec and the pins are latched at 0.1 N by magnetic force. The pins are arranged at a pitch of 2.5 mm and move 2 mm up and down. A multi-step magnetic latch has been developed for a 3-D expression. By using these mechanisms, several tactile information, e.g. 2-D, 3-D, dynamic motions, can be easily displayed.

  110. Focused ultrasonic device for sonodynamic therapy in the human body

    A Yasui, Y Haga, JJ Chen, H Wada

    2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology　2005　154-157　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548411 　

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    Sonodynamic therapy is a new modality based on the synergistic effect of ultrasound and a chemical compound referred to as "sonosensitizer" for treatment of diseased sites such as cancer. However, by external ultrasound exposure, it is difficult to transmit ultrasound deep within the human body at adequate intensity because of transmission losses caused by the difference of specific acoustic impedance between media. Therefore, the aim of this study is to develop focused ultrasonic transducers using concave-shaped PZT for localized sonodynamic therapy in the human body. A concave-shaped PZT was fabricated from a bulk PZT using a high-speed micro-milling machine, and then repolarized for the optimized polarization direction. The measurement result of the acoustic field using a PVDF hydrophone indicated that the ultrasound emitted from the transducer was successfully focused in three-dimensions. At the focal point, the measured peak intensity would be sufficient for sonodynamic therapy.

  111. Small diameter hydraulic active bending catheter using laser processed super elastic alloy and silicone rubber tube

    Y Haga, Y Muyari, T Mineta, T Matsunaga, H Akahori, M Esashi

    2005 3RD IEEE/EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGY IN MEDICINE AND BIOLOGY　2005　245-248　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548439 　

    ISSN：1049-3565

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    Small diameter active bending catheter which is actuated by hydraulic suction mechanism for intravascular minimally invasive diagnosis and therapy, has been developed The catheter is made of a Ti-Ni super elastic alloy (SEA) tub, which is processed by laser micromachining and a silicone rubber tube which covers the outside of the SEA tube. The processed SEA tube consists of a line of rings connected with meandering beams. The active catheter is filled with water and its bending angle is controlled from outside the body by suction of the water. The tip of the silicone rubber tube functions as a valve and closes by initial suction of the water, and the catheter is bent by subsequent suction. External diameter of the fabricated bending active catheter is 0.94 mm and the internal diameter is 0.85 mm. Inner space of the catheter functions as a working channel for insertion medical tools and fluids. The active catheter is effective for insertion in branch of blood vessel which diverse in acute angle which is difficult to proceed, and selective embolization of arteries for treatments tumors. The bending mechanism can be used safely in blood vessel because of its simple structure and materials which is assessed for medical use.

  112. Application of stand-by switching large core diameter optical fiber switch

    MMI Bhuiyan, Y Haga, M Esashi

    IEEE/LEOS Optical MEMs 2005: International Conference on Optical MEMs and Their Applications　151-152　2005

    Publisher: IEEE

    DOI： 10.1109/OMEMS.2005.1540123 　

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    A 1 x 2 optical switch using POF/PCF and an SMA coil actuator with magnetic latches is fabricated and tested. A stand-by switch using the fabricated fiber switches is assembled and its operation is confirmed.

  113. Tactile display for 2-D and 3-D shape expression using SMA micro actuators

    T Matsunaga, K Totsu, M Esashi, Y Haga

    2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology　2005　88-91　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548391 　

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    Tactile display which displays character and graphic information dynamically from computer by making pins array up and down has been developed. Shape Memory Alloy (SMA) micro-coil actuators contract and make the pins up and down when an electrical current is supplied. Magnetic material tube is attached to each pin and a permanent magnet fixes position of the pins up or down. Electrical consumption is low because the current is supplied only when the pins move. A 2-D tactile display which has 100 (10 x 10) pins array has been developed and successfully operated. The tactile information were displayed sequentially every 0.3 second and the pins were latched at 0.1 N by magnetic force. The pins are arranged at a pitch of 2.5 mm and move 2 mm up and down individually. In order to present the tactile information accurately, narrower pin pitch of the tactile display is preferable. A module for tactile display with a pin pitch of 1.27 mm has been fabricated and successfully operated. A multi-step magnetic latch has been developed for a 3-D tactile display. By using these mechanisms, large displacement and accurate positioning of the pin for 3-D expression can be realized.

  114. Piezoelectric 2D microscanner for precise laser treatment in the human body

    H Akahori, Y Haga, T Matsunaga, K Totsu, H Iseki, M Esashi, H Wada

    2005 3RD IEEE/EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGY IN MEDICINE AND BIOLOGY　2005　166-169　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548415 　

    ISSN：1049-3565

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    Laser irradiation in the human body using an optical fiber is an effective method of minimally invasive laser treatment. For realizing precise laser treatment in the human body, a two-dimensional (2D) laser scanning micro tool has been developed. A laser is transmitted through an optical fiber and a micro rod lens. The laser is reflected and scanned by a 2D microscanner and focused on an objective area. The fabricated 2D microscanner has three piezoelectric unimorph cantilevers that have a ball joint at each tip and a mirror. The mirror is supported by a pivot from underside and is inclined by pushing down by three cantilevers on the top of the mirror. The maximum inclined angle of the mirror is 30 degrees. Using potasium-titanyl-phosphate (KTP) laser, a function of the laser scanning is confirmed. For insertion the 2D laser scanning micro tool into a working channel of a conventional endoscope, these components are assembled and packaged into a tube. In the future, this tool can be used not only for laser treatment but also for in vivo microscopic inspection. By combining the 2D microscanner and the microscopic inspection techniques, for example micro confocal laser scanning microscope or Endoscopic Optical Coherence Tomography (EOCT), the tool might be more effective for precise laser treatment.

  115. Active bending ileus tube using shape memory alloy for treatment of intestinal obstruction

    Y Haga, M Mizushima, T Matsunaga, K Totsu, M Esashi

    2005 3RD IEEE/EMBS SPECIAL TOPIC CONFERENCE ON MICROTECHNOLOGY IN MEDICINE AND BIOLOGY　2005　249-252　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548440 　

    ISSN：1049-3565

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    Soft and long silicone rubber tube (Long Intestinal Tube; LIT) is commonly used for conservative treatment in intestinal obstruction (ileus). The LIT is inserted into the intestine for depressurization by continuous suction from outside the body. In insertion of the tube, it is difficult to pass the lower opening of the stomach (pylorus) because of its narrowness. An LIT that has stainless steel weights at the tip is most widely used for the insertion. This tube utilizes gravity to facilitate manipulation of the tip. However, a patient must endure pain when he or she changes position. For accurate positioning of the tip, active bending LIT using shape memory alloy (SMA) coil micro actuator, which contracts by supplying electrical current has been developed. The tube consists of a bending tip (external diameter, 6 mm; length, 40 mm) and a 3-m-long silicone rubber tube. It enables easier and more reliable passage at the pylorus. The maximum bending angle was 110 degrees and the bending tip is flexible even if it bends because of softness of the SMA micro-coil. The surface temperature of the tip during active bending motion was measured under conditions of 38 degrees C and it takes 45 seconds for the surface temperature to rise over 41 degrees C when the bending angle is maintained at 30 degrees.

  116. Forward-looking ultrasound imager using convex-shaped 1-3composite transducer for intravascular treatment

    JJ Chen, Y Haga, O Oshiro, K Chihara, M Esashi

    2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology　2005　345-348　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548469 　

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    An intravascular forward-looking ultrasound probe (FLUP) of 3 mm in diameter has been developed. We used the FLUP as acoustic sources and receivers to make an ultrasound forward-looking image, but many artifats were observed because of strong directivity of the FLUP. To confirm the affection of directivity, in ultrasound forward-looking images, laser induced breakdown (LIB) was used as a low directional transmitter and a FLUP was used as a receiver, a fine image was successfully obtained because the LIB can provide an almost completely spherical ultrasound pulse wave. For decreasing the directivity, of FLUP, convex-shaped 1-3 composite PZT transducer (0.7 mm in diameter and 0.75 mm curvature radius) was fabricated, and low directivity feature was confirmed. A probe which has eight separated 1-3 composite convex-shaped transducers were fabricated. The probe is 3 mm in diameter and a working channel is 0.5 mm in diameter. Acoustic pressure was measured using a hydrophone which was located 10 mm in front of the FLUP. The emitting acoustic pressure of 40 Pa was realized with the fabricated probe. When the probe was used as acoustic sources and receivers, echo signal of an aluminum plate was observed.

  117. 125 mu m diameter fiber-optic pressure sensor system using spectrometer- based white light interferometry with high-speed wavelength tracking

    K Totsu, Y Haga, T Matsunaga, M Esashi

    2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology　2005　170-173　2005

    Publisher: IEEE

    DOI： 10.1109/MMB.2005.1548416 　

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    A fiber-optic Fabry-Perot interferometric medical pressure sensor of 125 pm in diameter and results of animal experiments are presented. A Fabry-Perot cavity is formed at an optical fiber end using MEMS (Micro Electro Mechanical Systems) technology. Deformation of the diaphragm of the sensor induced by pressure varies the Fabry-Perot cavity length. White light interferometry is used for detecting the change of cavity length to avoid noise caused by bending of the optical fiber and fluctuation of the light source. The spectrum of the modulated reflection light from the sensor interferometer is measured by high-speed spectrometer controlled by a micro-controller with parallel signal processing. The detection system tracks peak wavelengths of the modulated light and determines the sensor cavity length, which corresponds the applied pressure. Pressure changes have been monitored by using the developed detection system. The total rate of sampling at the spectrometer, data transfer from the spectrometer to the micro-controller, calculation and data output is 800 Hz. Animal experiments using a rat have been carried out and dynamic blood pressure changes in a carotid artery have been successfully monitored.

  118. Addition of rhythm to non-pulsatile circulation

    Biomedicine and Pharmacotherapy　58　2004/10/01

    DOI： 10.1016/S0753-3322(04)80024-6 　

    ISSN：0753-3322

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    The development of a rotary blood pump (RP) is desirable as it can be used as a small ventricular assistance device (VAD). However, a RP does not generate any pulse. It may be physiologically better for the patient if the RP could generate a pulse. We have attempted to develop a device that produces a pulse in the RP. Intra-aortic balloon pumping (IABP) is effective in producing a pulse. However, the IABP cannot be implanted inside the body. Therefore, an attempt was made to develop pulse-generating equipment that was not driven by air pressure. The ball screw motor was considered as a possible candidate. In the future, we plan to apply small shape memory alloys. An electrohydraulic system was adopted, and actuator power output was connected to the diaphragm. The diaphragm was placed outside the ventricle. Most RPs developed throughout the world drain blood from the ventricle. The pulse wave should be generated if a pulse is added by the part from which blood is being drawn. In this study, animal experiments were conducted and the output assistance was tested from outside the ventricle. The device operated effectively in the animal experiment. The RP can easily be equipped with this device at the time of performing the implant operation. For a patient with problems of peripheral circulation and the internal organ fiunction, it may prove to be an effective device. © 2004 Elsevier SAS. Tous droits réservés.

  119. Development of an implantable undulation type ventricular assist device for control of organ circulation

    T Yambe, Y Abe, K Imachi, Y Shiraishi, MI Shibata, T Yamaguchi, QT Wang, XD Duan, HJ Liu, M Yoshizawa, A Tanaka, H Matsuki, F Sato, YI Haga, M Esashi, K Tabayashi, Y Mitamura, H Sasada, M Umezu, T Matsuda, SI Nitta

    ARTIFICIAL ORGANS　28　(10)　940-944　2004/10

    Publisher: BLACKWELL PUBLISHING INC

    DOI： 10.1111/j.1525-1594.2004.07382.x 　

    ISSN：0160-564X

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    It is well known that a rotary blood pump (RP) is effective as a small ventricular assist device (VAD). It might be still more effective if pulsation was available. The undulation pump (UP), which is a type of small RP, can also produce pulsation. In Japan, a development project for an implantable type UP ventricular assist device (UPVAD) is now advanced. Six universities and some companies together have been in charge of the development project for 5 years. In this study, the influence which the UP under development has on circulation in internal organs was investigated. Goats with the same weight as an average Asian person were used for the experiment. The left chest cavity was opened after resection of the fourth rib and the heart was approached. A cannula was inserted in the left ventricle from the apex. An outflow cannula was inserted into the left descending aorta. Heart muscle was excised using a newly developed puncher. The UPVAD was implanted using a left-heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were recorded together with an electrocardiogram, blood pressure, and the flow rate. In these animal experiments, the blood circulation dynamic state was stabilized and sufficient support of the left heart was observed. Myocardial blood flow, carotid arterial flow, and a kidney blood flow increase resulting from UPVAD support was observed. Often the problem of multiple organ failure is important at the time of clinical application of a ventricular assist device. Assisting circulation to internal organs is important for prevention of multiple organ failure. It was concluded that the UPVAD might be useful for prevention of multiple organ failure.

  120. Component engineering for an implantable system

    QT Wang, T Yambe, Y Shiraishi, M Esashi, Y Haga, M Yoshizawa, F Sato, H Matsuki, K Imachi, Y Abe, H Sasada, S Nitta

    ARTIFICIAL ORGANS　28　(10)　869-873　2004/10

    Publisher: BLACKWELL PUBLISHING INC

    DOI： 10.1111/j.1525-1594.2004.07383.x 　

    ISSN：0160-564X

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    Component engineering is important for the development of implantable-type rotary blood pumps (RP). The authors are conducting elementary development of an implantable artificial heart. A sensor system detects information in the living body. An automatic control system performs the drive control. Energy is provided by a transcutaneous energy transmission system (TETS). Various artificial hearts are being created. Miniaturization resulting from an increase in operating frequency is planned. A vibrating flow pump (VFP) has a reduced size of pumping chamber because of the high-speed reciprocating movement. Undulation pump ventricular assist devices (UPVAD) are small, lightweight rotary pumps. VFPs are useful in the medical treatment of multiple organ failure (MOF). UPVADs are planned to be permanent-use RPs. The purposes of these two artificial hearts differ, although they have a common component. The authors are developing TETS by using amorphous fibers, making efficient power transmission possible. Control information input from a micro or nano sensor is realized. A control algorithm has been developed and baroreflex control has been successful. Artificial heart development, fully exploiting component engineering, continues.

  121. Optical Switches for Large Core Diameter Optical Fibers (POF &amp; PCF)

    Proceedings of SPIE - The International Society for Optical Engineering　5346　126-133　2004/05/10

    DOI： 10.1117/12.532259 　

    ISSN：0277-786X

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    POF (Plastic Optical Fiber) is more suitable than the quartz optical fiber for indoor LAN (Local Area Network), for example in-home or office networks because of its flexibility and ease of connection by relatively large core diameter. 1 x 2 optical switches for indoor LAN using POF have been developed. For switching by movement of a POF, large displacement is necessary as core diameter is large (e.g. 0.486mm). A SMA (shape memory alloy) coil actuator is used for large displacement and a magnetic latching system is used for fixing the position of the shifted POF. Switching speed is less than 0.5 second and the insertion loss of the fabricated switch is 0.40 to 0.50dB. The insertion loss is 0.06 to 0.09dB using index-matching oil. PCF (Plastic Clad Fiber) has also large core diameter (e.g. 0.20mm) and an optical switches using PCF will be useful for short distance network between buildings.

  122. ナノテクを応用した人工臓器開発の新しい地平 (未来材料)

    山家智之, 掘 義生, 井ロ篤志, 芳賀洋一, 吉澤 誠, 松木英敏, 川野恭之, 高木敏行, 圓山重直, 段 旭東, 井街 宏, 佐藤英明, 久保 豊, 梅津光生, 前田 剛, 白石泰之, 田林晄一, 江刺正喜, 田中 明, 佐藤文博, 羅 雲, 早瀬敏幸, 王 慶田, 仁田新一, 佐々田比呂志, 岡本英治, 大坂元久, 本間 大

    未来材料　4　(8)　30-37　2004/04

  123. 新しい血管内超音波イメージング装置の開発 血管内前方視超音波内視鏡 (検査技術)

    芳賀洋一, 陳 俊傑, 江刺正喜

    検査技術　9　(12)　12-16　2004/04

  124. マイクロ・ナノマシニング技術を用いた低侵襲検査・治療機器 (日本AEM学会誌)

    芳賀洋一, 江刺正喜

    日本AEM学会誌　12　(2)　106-111　2004/04

  125. Development of Intracorporeal Therapeutic Device Using Piezoelectric 2D Microscanner

    Akahori Hiromasa, Haga Yoichi, Esashi Masayoshi, Wada Hiroshi

    2004　(16)　115-116　2004/01/21

    Publisher: The Japan Society of Mechanical Engineers

  126. 低侵襲医療のためのマイクロマシニング (日本医事新報)

    芳賀洋一

    日本医事新報　4159　131-132　2004/01/10

  127. Fabrication of low directional acoustic transducers for intravascular forward-looking imaging

    JJ Chen, Y Haga, H Akahori, O Oshiro, K Chihara, M Esashi

    MEMS 2004: 17TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, TECHNICAL DIGEST　857-860　2004

    Publisher: IEEE

    ISSN：1084-6999

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    This paper describes an intravascular ultrasound forward-looking imaging and a fabrication of low directional acoustic transducer. We used a forward-looking ultrasound probe (FLUP) as acoustic sources and receivers to make an ultrasound forward-looking image, but a clear image could not be obtained because of strong directivity of the FLUP. By using laser induced breakdown (LIB) as acoustic sources and the FLUP as receivers, a fine image of reflector was successfully obtained because of the LIB can provide an almost completely spherical ultrasound pulse wave. For using LIB in a human body, an intravascular fiber-optic ultrasound transmitter was fabricated. A low directional convex shape 1-3 composite PZT transducer (0.7 mm in diameter and 0.75 mm curvature radius) was fabricated. Decreased the directivity of the fabricated convex shape 1-3 composite PZT was confirmed, and an 8 ring-array convex shape 1-3 composite PZT transducers (3 mm in outside diameter and 1.5 mm in inside diameter) has been fabricated as receivers. These low directional acoustic transducers are suitable for decreasing the directional loss of the echo signal from the reflector.

  128. Large displacement optical switching mechanism using SMA microactuator and magnetic latch

    MMI Bhuiyan, Y Haga, M Esashi

    MEMS 2004: 17TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, TECHNICAL DIGEST　61-64　2004

    Publisher: IEEE

    ISSN：1084-6999

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    POF (Plastic Optical Fiber) is more suitable than the quartz optical fiber for indoor LAN (Local Area Network), for example in-home or office networks because of its flexibility and ease of connection by relatively large core diameter. 1 x 2 optical switches for indoor LAN using POF have been developed. For switching by movement of a POF, large displacement is necessary as core diameter is large (e.g. 0.486mm). A SMA (shape memory alloy) coil actuator is used for large displacement and a magnetic latching system is used for fixing the position of the shifted POF Switching speed is less than 0.5 second and the insertion loss of the fabricated switch is 0.40 to 0.50dB. The insertion loss is 0.06 to 0.09dB using index-matching oil. PCF (Plastic Clad Fiber) has also large core diameter (e.g. 0.20mm) and an optical switches using PCF will be useful for short distance network between buildings.

  129. Development of Intravascular Forward-looking Ultrasound Probe

    CHEN J. J., HAGA Yoichi, Akahori Hiromasa, ESASHI Masayoshi

    Proceedings of the ... JSME Conference on Frontiers in Bioengineering　2003　(14)　113-114　2003/09/17

    Publisher: The Japan Society of Mechanical Engineers

    ISSN：1348-2939

  130. ナノテク集積人工心筋開発プロジェクト (循環制御)

    山家智之, 白石泰之, 井口篤志, 田林晄一, 芳賀洋一, 江刺正喜, 吉澤 誠, 田中明, 松木英敏, 佐藤文博, 川野恭之, 羅 雲, 高木敏行, 早瀬敏幸, 圓山重直, 王慶 田, 段 旭 東, 新田新一, 岡本英治, 久保 豊, 大坂元久, 梅津光生

    循環制御　24　(2)　111-117　2003/04

  131. 26.二次元触覚ディスプレイの開発(平成14年度東北支部大会抄録)

    牧志 渉, 芳賀 洋一, 岩見 健太郎, 江刺 正喜

    生体医工学 : 日本エム・イー学会誌　41　(1)　69-69　2003/03/10

    Publisher: 社団法人日本生体医工学会

    ISSN：1347-443X

  132. Development of Optical Switch Using SMA Coil and Magnetic Latch

    Moinul Islam Bhuiyan, Haga Yoichi, Makishi Wataru, Esashi Masayoshi

    Proceedings of the IEICE General Conference　2003　(2)　615-615　2003/03/03

    Publisher: The Institute of Electronics, Information and Communication Engineers

  133. Non-planer Photo-fabrication of an Actuator-Unit from a Shape Memory Alloy Pipe

    Takashi Mineta, Yoichi Haga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　123　(5)　158-162　2003

    DOI： 10.1541/ieejsmas.123.158 　

    ISSN：1347-5525 1341-8939

    eISSN：1347-5525

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    This paper reports a new photo-fabrication method of an actuator unit from a shape memory alloy (SMA) pipe. Three meandering actuators, which are linked one another, have been fabricated from an SMA pipe. The outer diameter and the wall thickness of the pipe are 600μm and 50μm, respectively. After the SMA pipe was dip coated with positive photoresist, the photoresist was patterned by using projection exposure method for an etching mask. The SMA pipe was electrochemically etched in the LiCl-ethanol solution with a Cu dummy layer, which was deposited on the inside wall of the pipe by electroless plating previously. The batch fabrication method can simplify the assembly of an active catheter, because the actuators are fabricated as a self-assembled unit. Keywords : shape memory alloy, pipe, actuator, non-planer, photo-fabrication. © 2003, The Institute of Electrical Engineers of Japan. All rights reserved.

  134. Bach fabrication of microlens at the end of optical fiber using self-photolithgraphy and etching techniques

    Phan Ngoc Minh, Takahito Ono, Yoichi Haga, Kazumi Inoue, Minoru Sasaki, Kazuhiro Hane, Masayoshi Esashi

    Optical Review　10　(3)　150-154　2003

    DOI： 10.1007/s10043-003-0150-4 　

    ISSN：1340-6000

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    This paper describes a simple batch process for fabrication of microlens and microlens array at the end of an optical fiber or an optical fiber bundle using self-photolithography and etching techniques. A photoresist micro-cylinder was exactly formed at the core of the fiber end by exposing an UV light from the other end of the fiber and conventional development, rinse processes. A photoresist microlens was formed by thermal reflowing of the fiber at 170°C for 1 h. A measurement of transmissivity showed that the fabricated photoresist microlens is applicable for a wavelength that is longer than 450 nm. Alternatively, a glass microlens was fabricated at the core of the fiber by dry etching with an SF6 gas using the photoresist microlens as a mask. The focusing of the lensed fiber was confirmed and simulation work showed that the lensed fiber could focus the light with a beam spot of 2 μm. numerical aperture (NA) of 0.285 and a depth of focus of 16 μm.

  135. Vacuum sealed ultra miniature fiber-optic pressure sensor using white light interferometry

    K Totsu, Y Haga, M Esashi

    BOSTON TRANSDUCERS'03: DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2　1　931-934　2003

    Publisher: IEEE

    DOI： 10.1109/SENSOR.2003.1215628 　

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    We have developed a fiber-optic Fabry-Perot interferometer pressure sensor of 125mum in diameter of which cavity is sealed in vacuum. White light interferometry is used to avoid noise caused by bending of the optical fiber and a fluctuation of the light source. The reflection light is measured by high-speed spectrometer. A Fabry-Perot cavity is formed at the optical fiber end. A deformation of the diaphragm induced by pressure varies the cavity length. To avoid influence of temperature change to the sensor output, the cavity is sealed in vacuum. The sensing element is bonded to the optical fiber end by soldering in vacuum. Sn layer is formed on the metal spacer of the sensing element and is bonded to the Cr/Cu/Au layer patterned at the optical fiber, end. Cr half-mirror is also patterned at the core of the fiber end for making interferometer. Pressure is successfully monitored in real-time using the sensor system.

  136. Piezoelectric 2D micro scanner for minimally invasive therapy fabricated using femtosecond laser ablation

    N Kikuchi, Y Haga, M Maeda, W Makishi, M Esashi

    BOSTON TRANSDUCERS'03: DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2　1　603-606　2003

    Publisher: IEEE

    DOI： 10.1109/SENSOR.2003.1215545 　

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    Piezoelectric two dimensional (21)) micro scanner was developed for medical laser scanning micro tool that is inserted in the human body and observes tissue microstructures optically and scans laser for treatment. The structure of developed micro scanner consists of three piezoelectric unimorph cantilevers, a mirror, three flexible joints and a pivot. The joints link the end of the unimorph cantilevers with the mirror. The size of the micro scanner part is 1.6mm x 5.0mm, and the thickness is 100mum. The mirror tilted in two dimensions and maximum tilting angle was 2.23 degree when 60V was applied. The 2D scanner and optical system will be packaged in a tube of 2mm diameter which can be inserted in a working channel of a conventional endscope.

  137. マイクロマシニング技術の外科臨床への応用 (Surgery Frontier)

    芳賀洋一, 江刺正喜

    Surgery Frontier　9　(1)　41-46　2002/04

  138. 低侵襲治療用マイクロマシンとセンサ (材料の科学と工学)

    芳賀洋一, 江刺正喜

    材料の科学と工学　39　(4)　28-31　2002/04

  139. 医科機器へのマイクロマシン技術の応用と課題 (医科器械学)

    芳賀洋一, 江刺正喜

    医科器械学　72　(8)　367-372　2002/04

  140. An active guide wire with shape memory alloy bending actuator fabricated by room temperature process

    T Mineta, T Mitsui, Y Watanabe, S Kobayashi, Y Haga, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　97-8　632-637　2002/04

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/S0924-4247(02)00021-3 　

    ISSN：0924-4247

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    An active guide wire of 0.5 mm outer diameter has been developed. The guide wire has a simple and flexible structure that consists of a NiTi shape memory alloy (SMA) bending actuator with meandering shape and a bias coil that is covered with thin polyurethane, tube. It can bend to one-direction by heating with electric current and is restored by the bias coil. Large current was necessary to bend the guide wire in water, however, it could bend over 60degrees. The rise of the surface temperature of the guide wire was less than 5 degreesC in water. The SMA bending actuator has been photo-fabricated from a flatten SMA sheet which was spread flat after it was memorized in curve-shape. In order to fabricate the actuator below the transition temperature of the SMA. a room temperature photo-fabrication process has been also developed. 2002 Elsevier Science B.V. All rights reserved.

  141. 低侵襲治療用マイクロマシンとセンサ (特集 マイクロマシンと材料)

    芳賀 洋一, 江刺 正喜

    材料の科学と工学　39　(4)　158-161　2002

    Publisher: 日本材料科学会

    ISSN：1347-4774

  142. Electrochemical etching of shape memory alloy using new electrolyte solutions

    Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS)　376-379　2002/01/01

    DOI： 10.1109/MEMSYS.2002.984281 　

    ISSN：1084-6999

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    This paper presents electrochemical etching characteristics of shape memory alloy (SMA) using new electrolytes of inorganic salt in alcohol, in comparison with conventional H2SO4-methanol solution. Pattern etching of SMA sheets could be carried out in the electrolyte solutions using LiCl and NH4Cl. Especially in the case of the 1mol/l LiCl -ethanol, good etching properties such as controllable low etch rate, uniform etching depth and flat etched surface were obtained. The etch factor (=etching depth/side etching width) was 1.5 in 1mol/l LiCl-ethanol and 2.0 in 0.1mol/l LiCl-ethanol. Throughout etching could be carried out by using a backside dummy metal. This etching technique has been applied to the micromachining of SMA sheet and SMA pipe for fabrication of actuators.

  143. Active catheter, active guide wire and related sensor systems

    Y Haga, T Mineta, M Esashi

    ROBOTICS, AUTOMATION AND CONTROL AND MANUFACTURING: TRENDS, PRINCIPLES AND APPLICATIONS　14　291-296　2002

    Publisher: TSI PRESS

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    Active catheters and active guide wires which move like a snake utilizing distributed Shape Memory Alloy (SMA) actuators have been developed for catheter-based minimally invasive diagnosis and therapy. Active catheters and guide wires can have. bending, torsional and extending mechanisms. Communication and control IC chips in the active catheter reduce the number of lead wires for control. An ultra minature fiber-optic pressure sensor, a forward-looking ultrasonic probe and a magnetic position and orientation sensor have been developed for multifunctional catheters and multifunctional guide wires. These moving mechanisms and several sensors, which are equipped near the tip of the catheter and the guide wire will provide detail information near the tip and have doctors perform delicate and effective catheter intervention.

  144. Development of active catheter, active guide wire and micro sensor systems

    Yoichi Haga, T. Mineta, K. Totsu, W. Makishi, M. Esashi

    Interventional Neuroradiology　7　(SUPPL. 1)　125-130　2001/12/01

    ISSN：1123-9344

    More details Close

    Active catheters and active guide wires which move like a snake have been developed for catheter-based minimally invasive diagnosis and therapy. Communication and control IC chips in the active catheter reduce the number of lead wires for control. The active catheter can be not only bent but also torsioned and extended. An ultra minature fiber-optic pressure sensor, a forward-looking ultrasonic probe and a magnetic position and orientation sensor have been developed for catheters and guide wires. These moving mechanisms and several sensors which are fitted near the tip of the catheter and the guide wire will provide detailed information near the tip and enable delicate and effective catheter intervention.

  145. Hybrid optical fiber-apertured cantilever near-field probe

    Phan Ngoc Minh, Takahito Ono, Hisashi Watanabe, Seung Soup Lee, Yoichi Haga, Masayoshi Esashi

    Applied Physics Letters　79　(19)　3020-3022　2001/11/05

    DOI： 10.1063/1.1416475 　

    ISSN：0003-6951

    More details Close

    In this letter, we propose a hybrid optical fiber-apertured cantilever probe for optical near-field applications. A thermal SiO2 cantilever beam with a SiO2 pyramidal tip was formed by Si micromachining technique and bonded with an optical fiber using a polyimide adhesive layer. A subwavelength aperture at the apex of the SiO2 tip was formed by etching the SiO2 in a buffered-HF solution. Optical near-field imaging in contact mode was observed with the fabricated probe. The probe could work in contact mode because the cantilever at the end of the fiber can flexibly move on the sample surface. By detecting the far-field light which is reflected-back by the tip of the cantilever, the vibration of the cantilever was observed using the probe itself. With the proposed structure, a hybrid fiber bundle-apertured cantilever array is feasible for application in parallel near-field processing or data storage. © 2001 American Institute of Physics.

  146. Medical active catheter (Expected Materials for the Future)

    芳賀洋一, 江刺正喜

    Expected Materials for the Future　1　(7)　41-47　2001/07

  147. ナノ医療マシン その現状と展望 (ACCESS)

    江刺正喜, 芳賀洋一

    ACCESS　16　(6)　33-35　2001/04

  148. MM5 マイクロマシンの可能性

    江刺 正喜, 芳賀 洋一

    日本外科学会雑誌　102　185-185　2001/03/10

    Publisher: 一般社団法人日本外科学会

    ISSN：0301-4894

  149. Batch fabricated flat meandering shape memory alloy actuator for active catheter

    T Mineta, T Mitsui, Y Watanabe, S Kobayashi, Y Haga, M Esashi

    SENSORS AND ACTUATORS A-PHYSICAL　88　(2)　112-120　2001/02

    Publisher: ELSEVIER SCIENCE SA

    DOI： 10.1016/S0924-4247(00)00510-0 　

    ISSN：0924-4247

    More details Close

    We have developed a new batch fabrication process of a shape memory alloy (SMA) sheet based on electrochemical pulse etching with a sacrificial dummy metal layer. The method has realized a throughout micromachining of the SMA sheet. Using the new batch fabrication process, flat meandering S-shape SMA actuators of 38 mum in thickness have been developed. The actuators whose widths were narrower than 290 mum could generate the forces over 75 mN. The batch fabrication process was also applied to a micromachining of NiTi super elastic alloy (SEA) helical coils. A small outer diameter active catheter was developed by using the flat meandering SMA actuators of 290 mum in width and the SEA helical coil of about 460 mum in outer diameter. The outer diameter of the catheter without an outer tube was 0.8 mm. A silicon rubber outer tube of 75 mum in wall thickness was put on the catheter, nevertheless, the outer diameter was smaller than 1 mm. The bending angle of the developed active catheter without the outer tube was about 50 degrees at heating current of 60 mA. The bending angle tended to be lower after the outer tube was put on, however, the catheter with outer tube could be bent to the angle of 35 degrees. (C) 2001 Elsevier Science B.V. All rights reserved.

  150. A thermomechanical relay with microspring contact array

    YX Liu, XH Li, T Abe, Y Haga, M Esashi

    14TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS, TECHNICAL DIGEST　220-223　2001

    Publisher: IEEE

    ISSN：1084-6999

    More details Close

    A micromachined thermomechanical relay with Au microspring contact array is presented. Thermally excited Al-SiO2 bimorph cantilevers have been fabricated with micromachining technology Sputtered Au/Pt/Ti contacts are formed on the tip of the cantilevers and microheaters are built in the cantilevers. In order to reduce the ON-resistance and to avoid the metallic binding between Au contacts, Au microspring contact array is fabricated on Pyrex glass. The fabricated thermomechanical microrelay is operated with input power levels ranging from 20-80 mW at frequencies up to 3 KHz. The ON resistance R-ON, that includes contact resistance and signal line resistance is in the range of 200-500 m Omega and switching time is about 300 mu sec. 10(7) cycles operation has been performed keeping the R-ON around 300 m Omega.

  151. Microsystem and its application fom bioengineering

    T. Ono, Y. Haga, K. Takahashi, M. Esashi

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme　45　(15)　2542-2549　2000/11

    ISSN：0039-9450

  152. Active catheter (InterLab)

    芳賀洋一

    InterLab　20　37-39　2000/06

  153. カテーテル搭載用光ファイバ圧力センサ (計測と制御)

    芳賀洋一, 勝間田卓, 南和幸, 江刺正喜

    計測と制御　39　(4)　292-295　2000/04

    Publisher: The Society of Instrument and Control Engineers

    DOI： 10.11499/sicejl1962.39.292 　

    ISSN：0453-4662

  154. 医療用能動カテーテル (SUT BULLETIN)

    芳賀洋一

    SUT BULLETIN　17　(5)　32-37　2000/04

  155. マイクロシステムとそのバイオへの応用 (蛋白質 核酸 酵素)

    小野崇人, 芳賀洋一, 高橋一憲, 江刺正喜

    蛋白質 核酸 酵素　45　(15)　2542-2549　2000/04

  156. New trend of micromachining and medical application (This is Medicine in Japan)

    芳賀洋一, 江刺正喜

    This is Medicine in Japan　27　(2)　64-67　2000/02

  157. Batch fabricated flat winding shape memory alloy actuator for active catheter

    T. Mineta, T. Mitsui, Y. Watanabe, S. Kobayashi, Y. Haga, M. Esashi

    Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS)　375-380　2000/01/01

    More details Close

    Batch fabrication process of a shape memory alloy (SMA) sheet based on electrochemical pulsed etching with a sacrificial dummy metal layer has been studied and flat winding S-shape SMA actuators have been developed. The actuators are 38 μm in thickness and generated forces from 40 to 95 mN were obtained according to the width from 410 to 170 μm. The flat winding SMA actuator could realize active catheter with small outer diameter and wide inner working channel. The batch fabrication process was also applied to micromachining of NiTi super elastic alloy (SEA) for biasing spring of the catheter.

  158. Assembly of Bending, Torsional and Extending Active Catheter Using Electroplating

    Yoichi Haga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　120　(11)　515-520　2000

    DOI： 10.1541/ieejsmas.120.515 　

    ISSN：1347-5525 1341-8939

    More details Close

    This paper reports a new batch fabrication method of active catheters which have bending, torsional and extending functions for steering. The active catheter consists of shape memory alloy (SMA) coil actuators and a liner coil to return to its original shape. The SMA coil and the liner coil are connected each other using electroplating of nickel and electrodeposition of acrylic polymer. This novel method makes low cost assembly and small diameter (ϕ1.4mm) possible. © 2000, The Institute of Electrical Engineers of Japan. All rights reserved.

  159. Bending, torsional and extending active catheter assembled using electroplating

    HAGA Y.

    Proceedings of the IEEE Micro Electro Mechanical Systems (MEMS)　181-186　2000/01/01

    More details Close

    This paper reports a new batch fabrication method of active catheters which have bending, torsional and extending functions for medical applications. The active catheter consists of shape memory alloy (SMA) coil for actuator and a stainless steel liner coil. The SMA coil and the liner coil are connected using nickel electroplating and acrylic resin electrodeposition. This novel method makes low cost assembly and small diameter (φ1.4 mm) possible. New fabrication method of small diameter and thin wall tubular structure which is suitable for active catheters was developed. The tubular structure consists of stainless steel spring coil, evaporated parylene membrane and dip coated biocompatible polyurethane.

  160. Silicon bulk micromachining

    1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings　7-12　2000/01/01

    DOI： 10.1109/MMB.2000.893730 　

  161. Small Diameter Active Catheter Assembled Using Electroplating

    HAGA Yoichi, ESASHI Masayoshi

    1999　(22)　13-18　1999/11/11

  162. Fabrication of Thin-walled Tube Supported by Helical Coil for Small Diameter Active Catheter

    HAGA Yoichi, ESASHI Masayoshi, MAEDA Shigeo

    1999　(22)　55-60　1999/11/11

  163. Micromachining and minimally invasive therapy (The Journal of The Institute of Electrical Engineers of Japan)

    江刺正喜, 芳賀洋一

    The Journal of The Institute of Electrical Engineers of Japan　119　(11)　689-691　1999/11

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejjournal.119.689 　

    ISSN：1340-5551

  164. Micromachining and medical devices, basic technology for development of medical devices (Clinical Engineering)

    芳賀洋一, 江刺正喜

    Clinical Engineering　10　(1)　10-18　1999/01

  165. Active Catheter Using Multi-Link-Joint Structure Fabricated in Silicon Wafer

    Takashi Mineta, Yoshiyuki Watanabe, Seiya Kobayashi, Yoichi Haga, Masayoshi Esashi

    IEEJ Transactions on Sensors and Micromachines　119　(12)　615-619　1999

    DOI： 10.1541/ieejsmas.119.615 　

    ISSN：1347-5525 1341-8939

    eISSN：1347-5525

    More details Close

    An active catheter using silicon multi-link-joint structure has been developed. This catheter has a function of controllable bending motion like a snake by incorporation of distributed shape memory alloy (SMA) coil actuators and restoring silicon springs. The mechanical structure that consists of links and connecting bendable beams was fabricated in silicon wafers by using bulk micromachining technique. This method has an advantage that plural catheters can be fabricated by batch process. © 1999, The Institute of Electrical Engineers of Japan. All rights reserved.

  166. Active catheter and microsensors for catheter

    Japanese Journal of Artificial Organs　27　662-670　1998/12/01

    ISSN：0300-0818

  167. Active Catheter and Microsensors for Catheter (The Japanese Journal of Artificial Organs)

    芳賀洋一, 江刺正喜

    The Japanese Journal of Artificial Organs　27　(5)　662-670　1998/05

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.27.5_662 　

    ISSN：0300-0818

  168. Micromachining technology for ultrasonic scanning in body cavity (Advanced Medicine)

    芳賀洋一, 江刺正喜

    Advanced Medicine　5　(1)　48-51　1998/02

  169. Small diameter active catheter using shape memory alloy

    Y Haga, Y Tanahashi, M Esashi

    MICRO ELECTRO MECHANICAL SYSTEMS - IEEE ELEVENTH ANNUAL INTERNATIONAL WORKSHOP PROCEEDINGS　419-424　1998

    Publisher: IEEE

    More details Close

    Three kinds of active catheters whose outside diameters are less than 2mm were fabricated. One uses polymer links, the other two are linkless active catheters using adhesive. Distributed shape memory alloy (SMA) coil were used as actuators for the active motion. There are endoskeletal type and exoskeletal type in the linkless active catheters. We have applied the endoskeletal type active catheter to intraureteral ultrasonography used in a kidney. Concept of an advanced multifunction active catheter is mentioned.

  170. Fractal Dimension Analysis of the Oscillated Blood Flow with a Vibrating Flow Pump

    Tomoyuki Yambe, Taro Sonobe, Shigeru Naganuma, Shin‐ichi Kobayashi, Shunsuke Nanka, Hiroshi Akiho, Yoshito Kakinuma, Mikio Mitsuoka, Shigeki Chiba, Noboru Ohsawa, Youichi Haga, Kenji Idutsu, Shin‐ichi Nitta, Takeo Fukuju, Makoto Miura, Naoki Uchida, Naoshi Sato, Kouichi Tabayashi, Akira Tanaka, Naohiko Yoshizumi, Kenichi Abe, Misako Takayasu, Hideki Takayasu, Makoto Yoshizawa, Toshihiro Maekawa, Hiroyuki Hashimoto

    Artificial Organs　19　(7)　729-733　1995

    DOI： 10.1111/j.1525-1594.1995.tb02413.x 　

    ISSN：1525-1594 0160-564X

    More details Close

    Abstract: To analyze the hemodynamic parameters during circulation with oscillated blood flow, nonlinear mathematical analyzing techniques, including fractal theory, were utilized. Vibrating flow pumps (VFP) were implanted as a left heart bypass, and the ascending aorta was clamped to constitute the total left heart circulation with oscillated blood flow in acute animal experiments using 7 adult goats. Using nonlinear mathematical analyzing techniques, reconstructed attractors of the arterial blood pressure waveform in the phase space during natural circulation and oscillated circulation were analyzed. Using the Grassberger‐Procaccia correlation dimension analyzing technique, fractal dimension analysis of the reconstructed attractor was performed. During VFP bypass, lower fractal dimensions of the reconstructed attractor were shown compared with those during natural heart circulation. The results suggest that lower dimensional chaotic dynamics contributed to the circulation with oscillated blood flow. © 1995 International Society for Artificial Organs

  171. CHAOTIC BEHAVIOR OF HEMODYNAMICS WITH VENTRICULAR ASSIST SYSTEM

    T YAMBE, S NANKA, T SONOBE, S NAGANUMA, S KOBAYASHI, H AKIHO, Y KAKINUMA, M MITSUOKA, S CHIBA, N OHSAWA, Y HAGA, K IDUTSU, S NITTA, T FUKUJU, M MIURA, N UCHIDA, N SATO, K TABAYASHI, A TANAKA, N YOSHIZUMI, K ABE, M TAKAYASU, H TAKAYASU, M YOSHIZAWA

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS　18　(1)　17-21　1995/01

    Publisher: WICHTIG EDITORE

    ISSN：0391-3988

    More details Close

    In order to analyze hemodynamic parameters during-left ventricular assistance as an entity and not as decomposed parts, non-linear mathematical techniques were utilized. Pneumatically actuated ventricular assist systems (VAS) were implanted as left heart bypasses in acute animal experiments, using healthy adult mongrel dogs. By the use of the non-linear mathematical technique, the arterial blood pressure waveform (AP) was embedded into the four-dimensional phase space and projected into the three-dimensional phase space. The Lyapunov numerical method was used as an adjunct to the graphical analysis of the state space. The phase portrait of the attractor showed a complex structure; a three dimensional solid torus with a screw type structure as a part, suggesting deterministic chaos in the AP without left ventricular assistance. Positive lyapunov exponents confirmed the existence of chaos. During counterpulsation mode left ventricular assistance, the phase portrait of the attractor showed a more complex structure, and positive Lyapunov exponents suggested a greater dimensional deterministic chaos. However, non-structured patterns were seen in the phase space during internal mode VAS driving, suggesting the possibility of dissipative dynamics in the four dimensional phase space. These results suggest that the cardiovascular system with counterpulsation mode VAS driving is in a homeochaotic state, which is thought to be a flexible and intelligent control system. And there is greater dimensional complex dynamics in the circulatory regulatory system with VAD during internal mode assistance.

  172. Identification of the deterministic chaos in cardiovascular dynamics by the use of the non-linear mathematics.

    Science Reports of the Research Institutes Tohoku University - Series C Medicine　39　1-5　1993/12/01

    ISSN：0371-2761

    More details Close

    Chaotic behavior in cardiovascular dynamics was thought to be one of the important information to analyze the circulatory regulatory system. Several investigators studied the attractor in the signals of the electrocardiogram, and found the strange attractor, suggesting dynamics compatible with deterministic chaos, by the use of the non-linear mathematics. It is interesting problem to analyze the hemodynamic parameters by the use of non-linear mathematics for the determination of the physiologically optimal circulatory condition. In this study, Chaos analyzing system was developed to identify the deterministic chaos in cardiovascular regulatory system by the use of the non-linear mathematics including phase plane plots, embedding, and lyapunov exponents. Time series data of the hemodynamic parameters in the chronic animal experiments was analyzed by this system, and satisfactory attractor was obtained by the use of the phase plane plots and embedding techniques. Furthermore, calculation of the lyapunov exponents showed the existence of the deterministic chaos in arterial blood pressure in the chronic animal experiments using adult goats, suggesting this tool is useful for analyzing cardiovascular dynamic behavior.

  173. Application of vibrating flow pump to membrane oxygenators - The influence of driving frequencies on the gas exchange efficiency

    Japanese Journal of Artificial Organs　22　902-907　1993/01/01

    ISSN：0300-0818

  174. The experimental evaluation of V(o) and E(max) of transient myocardial ischemia on the partial left heart bypass

    KAKINUMA Y., NITTA S., KATAHIRA Y., YAMBE T., SONOBE T., NAGANUMA S., AKIHO H., IZUTU K., KOBAYASHI S., HAGA Y., TANAKA M., MIURA M., SATOH N., MOHRI H., TAKEDA H., YOSHIZAWA M.

    Japanese Journal of Artificial Organs　22　(3)　718-723　1993/01/01

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.718 　

    ISSN：0300-0818

    More details Close

    In order to evaluate the effect of the left ventricular assist device (LVAD) on the transient myocardial ischemia, acute animal experiments of the left heart bypass were carried out using the model of transient ischemia obtained by ligaturing the proximal portion of a left anterior descending coronary artery. In this study, the maximum value of elastance (Emax) was calculated using pressure-volume curve (P-V curve), based on the hypothesis that the volume of zero (Vo) is constant during the experimental procedure. But, because of the possibility that the value of Vo may vary according to the circulatory conditions, it is necessary to evaluate the change of Vo on different conditions. Therefore, the value of Vo on three different conditions of transient myocardial ischemia were calculated from the data obtained by inserting ten beats of co-pulsation mode between two series of counter-pulsation mode. In those experiments, per-cent changes of Vo during occlusion and after re-perfusion were 105.5% and 98.8%, respectively. On the contrary, the Emax during occlusion showed significant per-cent reduction (51.5%) compared with the Emax after re-perfusion (104.3%). It was concluded that the variability of Vo was too small to produce effect on the Emax calculated from P-V curve by assuming the constant Vo. Our method, with which time-series data of Emax could be obtained, might produce a useful information concerning cardiac function.

  175. Identification of the origin of the rhythmical fluctuations in cardiovascular beat-to-beat variabilities

    YAMBE T., NITTA S., KATAHIRA Y., SONOBE T., NAGANUMA S., AKIHO H., KAKINUMA Y., KOBAYASHI S., HAGA Y., IZUTSU K., TANAKA M., FUKUJU T., MIURA M., UCHIDA N., SATO N., MOHRI H., KOIDE S., TAKEDA H., YOSHIZAWA M.

    Japanese Journal of Artificial Organs　22　(3)　754-759　1993/01/01

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.754 　

    ISSN：0300-0818

    More details Close

    In order to analyze the origin of the rhythmical fluctuations in hemodynamic parameters by the use of the spectral analyzing method, artificial heart, which have not the periodicities, were implanted in the adult goats. Two pneumatically actuated sac type blood pump were implanted as the biventricular bypass (BVB) to constitute the BVB type total artificial heart (TAH) model to compare the fluctuations in natural heart animal and TAH animal. After the BVB pumping was initialized, natural heart was electrically fibrillated. During artificial circulation, significant Mayer waves and respiratory waves were clearly shown. Spectral analyzing method including coherence function revealed the fact that Mayer waves were originated from the peripheral vascular resistance, and respiratory waves were originated from the pulmonary circulation. These results suggest that rhythmical fluctuations in cardiovascular variabilities were at least, partly originated from the non-cardiogenic periodicities.

  176. The experimental study of blood flow distribution during the cardiopulmonary bypass using vibrating flow pump (VFP)

    KOBAYASHI S, NITTA S, KATAHIRA Y, YAMBE T, SONOBE T, NAGANUMA S, KAKINUMA Y, AKIHO H, HAGA Y, TANAKA M, FUKUJU T, MIURA M, SATO N, MOURI H, HASHIMOTO H, KASAI T, HIYAMA H, WAKAI S, YOSHIZAWA M

    Japanese Journal of Artificial Organs　22　(3)　915-920　1993/01/01

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.22.915 　

    ISSN：0300-0818

    More details Close

    We have been developing the artificial heart using the vibrating flow pump (VFP), which can generate the high frequency blood flow. To determine the effect of high frequency blood flow on the hemodynamics, cardiopulmonary bypass (CPB) using VFP was performed in four adult goats. The carotid arterial flow (CAF) was recorded by the use of ultrasonic flow meter to estimate the effect of high frequency blood flow upon blood flow distribution. During 30Hz flow, the carotid arterial resistanse (CAR) was significantly decreased, though, the total peripheral resis-tance (TPR) was not significantly changed. On the other hand, both CAR and TPR was decreased during 10Hz flow. These results suggest that the frequency of blood flow affects the blood flow distribution during CPB.

  177. Effect of high frequency blood flow on fluctuations in hemodynamics

    YAMBE T, NITTA S, KATAHIRA Y, SONOBE T, NAGANUMA S, KAKINUMA Y, AKIHO H, IZUTSU K, KOBAYASHI S, HAGA Y, MATSUZAWA H, TANAKA M, FUKUJU T, MIURA M, SATO N, MOHRI H, IZUMI K, KOIDE S, TAKEDA H, HASHIYA H, YOSHIZAWA M, HIYAMA H, KASAI T, HASHIMOTO H

    Japanese Journal of Artificial Organs　21　(5)　1390-1394　1992/01/01

    Publisher: JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

    DOI： 10.11392/jsao1972.21.1390 　

    ISSN：0300-0818

    More details Close

    We have been developing the artificial heart using the vibrating flow pump (VFP), which can generate the high frequency blood flow about 10Hz/s. To determine the effect of high frequency blood flow on autonomic nervous system under general anestesia, fluctuations in hemodynamics was analyzed by the spectral analysing method. Our newly developped VFP was utilized as the total left heart bypass in acute experiments using adult goats. During VFP pumping, respiratory waves were<br>not significantly changed (N.S.), though Mayer waves were significantly decreased (p<0.05). These results suggest that high frequency blood flow affects the autonomic nervous system, even during anesthesia.

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Books and Other Publications 14

  1. Electric Journal 別冊 2012 医療用エレクトロニクス技術大全 CD-ROM版

    芳賀洋一

    株式会社 電子ジャーナル　2012/03/05

  2. Electric Journal 別冊 2011 マイクロマシン/MEMS技術大全 CD-ROM版

    芳賀洋一

    株式会社 電子ジャーナル　2011/08/25

  3. Shape Memory Alloys

    Y. Haga, T. Mineta, W. Makishi, T. Matsunaga, M. Esashi

    Sciyo　2010/08

    ISBN: 9789533071060

  4. MEMS Materials and Processes Handbook / Edited by R. Ghodssi and P. Lin (Springer)

    T. Mineta, Y. Haga

    2010/08

  5. MEMS/NEMS工学全集

    芳賀洋一

    株式会社テクノシステム　2009/04/22

  6. 薄膜ハンドブック(第2版)

    芳賀洋一

    株式会社オーム社　2008/03/25

  7. Electronic Journal別冊 2008 マイクロマシン/MEMS技術大全

    芳賀洋一

    株式会社電子ジャーナル　2008/02/29

  8. MEMSマテリアルの最新技術

    芳賀洋一

    シーエムシー出版　2007/11/30

  9. Electronic Journal別冊 2006 マイクロマシン/MEMS技術大全

    芳賀洋一

    株式会社電子ジャーナル　2006/02/28

  10. Encyclopedia Sensors

    Y. Haga

    American Scientific Publishers　2005/10

  11. ソフトアクチュエータ開発の最前線

    長田義仁, d, 芳賀洋一, 峯田貴, 江刺正喜

    (株)エヌ・ティー・エス　2004/04

  12. Sensors Update vol.8

    H.Baltes, W.Gopel, J.Hesse ed, Y.Haga T.Mineta, M.Esashi

    WILEY-VCH　2001/04

  13. 金属便覧

    日本金属学会, d, 芳賀洋一

    丸善株式会社　2000/04

  14. バイオミメティックスハンドブック

    バイオミメティックスハンドブック編集委員会, 江刺正喜, 芳賀洋一

    (株)エヌ・ティー・エス　2000/04

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Presentations 183

  1. Real-time Monitoring of Spinal Cord Blood Flow with a Novel Sensor -mounted Cerebrospinal Drainage Catheter in an Animal Model International-presentation

    Y. Hayatsu, S. Kawamoto, T. Matsunaga, Y. Haga, Y. Saiki

    AATS (American Association for Thoracic Surgery; アメリカ胸部外科学会) 95th Annual Meeting (AATS 2014)　2015/04/25

  2. 磁性体チューブとアシストコイルを用いた細径電磁駆動単一光ファイバ内視鏡

    李 宣, 松永忠雄, 芳賀洋一

    第53回日本生体医工学会大会　2014/06/24

  3. 術中における心筋硬さ計測センサの開発

    松本 翼, 松永忠雄, 片平 晋太郎, 齋木佳克, 芳賀洋一

    第53回日本生体医工学会大会　2014/06/24

  4. 形状記憶合金ワイヤを用いた能動屈曲電子内視鏡の開発

    小林拓生, 松永忠雄, 芳賀洋一

    第53回日本生体医工学会大会　2014/06/24

  5. マイクロ・ナノマシニング技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    精密工学会東北支部総会 特別講演会　2014/04/17

  6. MEMS技術を利用した低侵襲医療・ ヘルスケア機器の開発と実装技術

    JEITA JJTR/STRJ講演　2014/03/13

  7. マイクロ・ナノマシニング技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    JIEP(一般社団法人 エレクトロニクス実装学会) 機能性ハイブリッド材料研究会 公開研究会 ＜医療の進化を支える実装技術＞　2014/02/24

  8. マイクロ・ナノマシニング技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    PST-net招待講演会　2014/02/21

  9. マイクロ・ナノマシニング技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    日立製作所、日立研究所講演　2014/01/31

  10. 医療用MEMSの最新技術動向

    Electronic Journal 第2073回 Technical Seminar　2014/01/29

  11. マイクロ・ナノ技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    東北ITソリューションEXPO 2013 JASA(組み込みシステム技術協会) 基調講演　2013/10/29

  12. マイクロシステムを用いた低侵襲医療機器・ヘルスケア機器の開発

    新化学技術推進協会 電子情報技術部会・次世代エレクトロニクス分科会 講演会　2013/10/07

  13. Development of Minimally Invasive Medical Devices and Healthcare Devices Using MEMS Technology International-presentation

    The International Symposium on Interdisciplinary Research and Education on Medical Device Developments (IREMD)　2013/09/13

  14. 非平面基板への微細加工と、医療、ヘルスケアデバイスへの応用

    松永忠雄, 芳賀洋一

    2013年度精密工学会秋季大会学術講演会　2013/09/12

  15. Active Bending Mechanism Using Shape Memory Alloy Wires International-presentation

    T. Kobayashi, T. Matsunaga, Y. Haga

    The 25th International Conference of the Society for Medical Innovation and Technology (SMIT 2013)　2013/09

  16. マイクロシステムを用いた低侵襲医療機器・ヘルスケア機器の開発

    第１回東北大学メディカルサイエンス・シンポジウム　2013/08/24

  17. 医療・ヘルスケア(健康管理)応用

    人材育成のためのMEMS集中コース in つくば （MEMS集中講義）　2013/08/08

    More details Close

    人材育成のためのMEMS集中コース in つくば （MEMS集中講義） ―TIA連携大学院サマー・オープン・フェスティバル2013― (主催：東北大学マイクロシステム融合研究開発センター（μSIC）、産業技術総合研究所集積マイクロシステム研究センター（UMEMSME）、MEMSパークコンソーシアム（MEMSPC）) 芳賀洋一

  18. マイクロ・ナノマシニング技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    組込み産業地域交流プラザ2013 in 宮城　2013/07/31

  19. Measurement of Subcutaneous Biological Substances Using Thin Metal Needle with Micro Flow Channel International-presentation

    N. Tsuruoka, K. Ishii, T. Matsunaga, R. Nagatomi, Y. Haga

    The 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13) in conjunction with 52nd Annual Conference of Japanese Society for Medical and Biological Engineering (JSMBE)　2013/07

  20. Minimally invasive microperfusion needle for continuous lactate monitoring during exercise International-presentation

    European College of Sport Science (ECSS)　2013/06/26

  21. Development and Evaluation of Tube-Shaped Neural Probe with Working Channel

    S. Tamaki, T. Matsunaga, T. Kuki, Y. Furusawa, H. Musiake, Y. Haga

    The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'2013) & Eurosensors XXVII　2013/06/16

  22. エレクトロニクスとMEMSの医療応用

    JPCA Show 2013(第43回国際電子回路産業展)　2013/06/05

  23. MEMS技術を利用した低侵襲医療・ヘルスケア機器の開発

    第27回エレクトロニクス実装学会春季講演大会　2013/03/13

  24. らせん巻きフィルムを用いた高機能・多機能なカテーテル・内視鏡の開発

    第27回エレクトロニクス実装学会春季講演大会　2013/03/13

  25. 医療用MEMSの最新技術動向

    Electronic Journal 第1558回 Technical Seminar　2013/01/25

  26. マイクロ・ナノ技術を用いた医療機器の開発

    東北大学 脳神経外科講演　2013/01/09

  27. 極細径光ファイバ圧力センサの臨床応用への取組み

    東北大学病院臨床試験推進センターシンポジウム　2012/12/05

  28. マイクロ・ナノマシニング技術の医療・ヘルスケア応用

    電子情報技術産業協会(JEITA) 医療エレクトロニクスデバイス技術分科会 講演　2012/11/22

  29. マイクロ・ナノマシニング技術の医療・ヘルスケア応用

    プリンタブルデバイス実装(RPD)公開研究会　2012/11/21

  30. MEMS・ナノ技術を用いた低侵襲医療機器・ヘルスケア機器の開発と展望

    NBCIビジョン検討会講演　2012/11/09

  31. 医療用MEMSの最新技術動向と その応用と課題

    日本半導体商社協会(DASF)新技術・応用技術主催 最新技術講演会　2012/10/25

  32. マイクロ・ナノ技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    TDK材料研究所講演　2012/10/12

  33. Optimization for resonant characteristic of intraluminal MRI probe using integrated circuit (IC) chip of variable capacitors International-presentation

    Z. Kato, T. Matsunaga, Y. Matsuoka, K. Kuroda, M. Esashi, Y. Haga

    Interventional MRI Symposium　2012/09/22

  34. SMAワイヤを用いた能動屈曲電子内視鏡

    小林拓生, 松永忠雄, 芳賀洋一

    日本機械学会2012年度次大会　2012/09/10

  35. 医療 (カテーテル 他)

    MEMS集中講義 in 東京　2012/08/24

  36. マイクロ・ナノ技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    NBCIテクノロジー委員会 バイオ分科会講演　2012/07/31

  37. ミクロな機械が切り拓く新しい医療

    サイエンス・リーダーズ・キャンプ(SLC)講演　2012/07/31

  38. MEMS技術を用いた低侵襲医療機器・ヘルスケア機器の開発

    流体研ライフサイエンスクラスター講演会　2012/07/26

  39. ミクロな機械が切り拓く次世代の医療

    SSH東北大学公開講座(高大連携事業 地域開催公開講座)　2012/07/14

  40. Micro Hydraulic Bending Actuator for Minimally Invasive Medical Device International-presentation

    M. Matsuo, K. Abe, S. Suda, T. Matsunaga, Y. Haga

    The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers'2013) & Eurosensors XXVII　2012/06/16

  41. 医療用MEMSの技術動向

    ソニー株式会社 社内セミナー　2012/06/07

  42. 可変容量コンデンサを搭載した管腔内MRIプローブの開発

    加藤善太, 松永忠雄, 松岡雄一郎, 黒田 輝, 江刺正喜, 芳賀洋一

    第51回日本生体医工学会大会　2012/05/10

  43. 超音波計測を用いたウェアラブル血圧センサの開発

    鈴木大地, 西谷内啓介, 藤田勝博, 前平謙, 大橋靖知, 不破耕, 松永忠雄, 長谷川英之, 金井浩, 芳賀洋一

    第51回日本生体医工学会大会　2012/05/10

  44. 低侵襲医療用マイクロデバイスの開発

    PI-SMART in Sendai (スマート材料・デバイスの発展と技術イノベーション)　2012/04/27

  45. Medical Devices for Minimally Invasive Diagnostics and Therapy Using Micro/Nano Fabrication Technology

    文部科学省 私立大学戦略的研究基盤形成支援事業第 第3回公開シンポジウム　2012/03/13

  46. Medical Devices for Minimally Invasive Diagnostics and Treatment Using Micro/nano Fabrication Technology International-presentation

    Taiwan-Japan Joint Symposium on Medica Device Innovation　2012/03/10

  47. Medical Devices for Minimally Invasive Diagnostics and Treatment Using Micro/nano Fabrication Technology International-presentation

    台大醫工所VS日本東北大學 學術交流フォーラム　2012/03/09

  48. Development of Minimally Invasive Microdialysis Needle for Continuous Monitoring of Biological Substances International-presentation

    Technical Digest of the 25th IEEE International Conference on Micro ElectroMechanical Systems (MEMS 2012),　2012/01/29

  49. 医療用MEMSの最新技術動向

    Electronic Journal 第1094回 Technical Seminar　2012/01/27

  50. 非平面フォトファブリケーションを 利用した脳機能計測デバイスの開発

    生体情報インターフェース創生のためのフォトニクス研究会　2011/12/13

  51. 圧電技術の医療応用

    第134 回 電子セラミック・プロセス研究会 第134 回 電子セラミック・プロセス研究会　2011/11/19

  52. 圧電技術の医療応用

    第134 回 電子セラミック・プロセス研究会　2011/11/19

  53. MEMS 超音波センサを応用したウェアラブル血圧計の開発

    第45回 日本生体医工学会東北支部大会講演論文集　2011/10/29

  54. 体内埋込型超音波駆動マイクロポンプ

    日本機械学会東北支部第47期秋季講演会　2011/09/22

  55. 金属針上に微小流路を有したマイクロダイアリシスシステム

    日本機械学会東北支部第47期秋季講演会　2011/09/22

  56. 胃瘻カテーテル交換時に用いるセミディスポーザブルタイプ内視鏡の開発

    日本機械学会東北支部第47期秋季講演会　2011/09/22

  57. マイクロテクノロジーを用いた先進医療機器の開発

    第6回東北大学REDEEMシンポジウム (（共催）第15回GCOE国際シンポジウム)「東アジア・環太平洋地域と医療工学の未来」　2011/09/11

  58. ナノ・マイクロ技術による先進医療機器の開発

    Electronic Journal 第900回 Technical Seminar　2011/09/09

  59. ナノ・マイクロ技術による先進医療機器の開発

    Electronic Journal 第900回 Technical Seminar　2011/09/09

  60. 医療 (カテーテル 他)

    MEMS集中講義 in 京都　2011/08/11

  61. 液圧駆動を用いた能動屈曲屈カテーテル

    第50回日本生体医工学会大会　2011/04/29

  62. 細径ポリイミドチューブを用いた折れ曲がり変形内視鏡ツールの開発

    第50回日本生体医工学会大会　2011/04/29

  63. 光刺激機能を備えたチューブ型神経電極の開発

    第50回日本生体医工学会大会　2011/04/29

  64. マイクロシステムを用いた低侵襲医療機器・ヘルスケア機器の開発

    社内セミナー　2010/12/16

  65. マイクロテクノロジーを用いた先進医療機器の開発

    第6回東北大学REDEEMシンポジウム(（共催）第15回GCOE国際シンポジウム)「東アジア・環太平洋地域と医療工学の未来」　2010/09/11

  66. ナノ・マイクロ技術による 先進医療機器の開発

    Electronic Journal 第574回 Technical Seminar　2010/09/10

  67. ナノ・マイクロ技術による 先進医療機器の開発

    Electronic Journal 第574回 Technical Seminar　2010/09/10

  68. Acoupoint Stimulation Device Using Focused Ultrasound International-presentation

    鶴岡典子

    32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society　2010/08/31

  69. Acupoint Stimulation Device Using Focused Ultrasound International-presentation

    32nd Annual International Conference of the IEEE EMBS Buenos Aires　2010/08/31

  70. 体内で用いる医療デバイスの高機能化・多機能化

    化学工学会エレクトロニクス部会シンポジウム 「メディカルエレクトロニクスに於ける材料、プロセスとその応用」　2010/07/30

  71. Acupoint Stimulation Device Using Focused Ultrasound

    鶴岡典子, 関 隆志, 渡部正司, 松永忠雄, 芳賀洋一

    第49回日本生体医工学会大会　2010/06/25

  72. Bending Transformative Endoscope Capable of Multifunctionalization and Easy Insertion

    須田信一郎, 松永忠雄, 芳賀洋一

    第49回日本生体医工学会大会　2010/06/25

  73. MRI Probe for Intraluminal Side-view and Front-view Image Fabricated by Non-planar Photolithography

    松永忠雄, 松岡雄一郎, 黒田 輝, 芳賀洋一

    第49回日本生体医工学会大会　2010/06/25

  74. 体内で用いる医療デバイスの高機能化・多機能化

    JIEP最先端実装技術シンポジウム「情報通信産業の第三の波センサーネットワークとセンサーの開発」　2010/06/02

  75. 光とMEMS技術を用いた低侵襲医療デバイスの開発

    集積光デバイスと応用技術(IPDA)第４回研究会　2010/05/28

  76. MEMSって何？ -デジカメ・携帯電話そして医療機器・・・なんでも小さく高機能になる理由-

    まなびのめLive版公開講演　2010/05/01

  77. Development of Multilayer Coil Using Non-planar MEMS Prosess for Intralunminal MRI Probe International-presentation

    Joint Annual Meeting ISMRM-ESMRMB 2010　2010/05/01

  78. Development of Multilayer Coil Using Non-planar MEMS Process for Intraluminal MRI Probe International-presentation

    S. Ichimura, W. Quan, T. Matsunaga, Y. Matsuoka, K. Kuroda, Y. Haga

    Joint Annual Meeting ISMRM-ESMRMB 2010　2010/05/01

  79. マイクロ・ナノマシニングを用いた次世代医療機器の開発

    次世代電子セラミックス・プロセス研究会　2010/03/22

  80. マイクロテクノロジーを用いた低侵襲医療機器の開発

    秋田県泌尿器科集談会　2009/12/05

  81. 多機能化を目指した折れ曲がり変形内視鏡の開発

    第18回日本コンピュータ外科学会大会　2009/11/21

  82. 円筒型フレキシブル基板を用いた細径能動屈曲電子内視鏡

    第43回日本生体医工学会東北支部大会　2009/11/21

  83. Microsystems for Minimally Invasive Diagnostics and Treatment International-presentation

    56th ICAT/JTTAS Joint International Smart Actuator Symposium　2009/10/06

  84. 微細加工技術を用いた身体状態モニターの可能性と試み

    日本超音波医学会 第82回学術集会　2009/09/02

  85. 微細加工技術を用いた身体状態モニターの可能性と試み

    第8回情報科学技術フォーラム(FIT2009)　2009/09/02

  86. 医療・バイオ 関連(カテーテル、検体検査 他)

    MEMS集中講義 in 名古屋　2009/08/06

  87. マイクロシステムを用いた次世代医療ツール開発 ～耳鼻咽喉科分野への応用～

    仙台北部耳鼻咽喉科懇話会　2009/06/17

  88. 低侵襲検査・治療用超音波マイクロデバイス

    スマート・アクチュエータ／センサ委員会 定例会　2009/06/05

  89. マイクロシステムを用いた次世代の健康・医療機器開発

    産学連携セミナー「第46回寺子屋せんだい」　2009/05/26

  90. 低侵襲検査・治療用超音波マイクロデバイスの開発

    日本超音波医学会 第82回学術集会　2009/05/22

  91. MEMS技術を用いた医療機器開発

    九州バイオニックMEMS研究会 第1回講演会　2009/04/28

  92. 単一ファイバ電磁振動を用いた細径高解像度内視鏡

    第48回生体医工学会大会　2009/04/23

  93. Development of Multilayer Coil for Catheter-mounting Intraluminal MRI Probe

    第48回生体医工学会大会　2009/04/23

  94. マイクロヒーターを搭載したインテリジェント鍼灸針

    第48回生体医工学会大会　2009/04/23

  95. 脊髄虚血モニタリングのためのドレナージカテーテル搭載型超音波センサ

    第48回生体医工学会大会　2009/04/23

  96. 単一ファイバ電磁振動を用いた細径高解像度内視鏡

    単一ファイバ電磁振動を用いた細径高解像度内視鏡　2009/04/23

  97. 低侵襲検査・治療とマイクロシステムテクノロジー

    平成21年電気学会全国大会講演論文集　2009/03/17

  98. 低侵襲検査・治療とマイクロシステムテクノロジー

    平成21年電気学会全国大会　2009/03/17

  99. ドレナージカテーテル搭載型脊髄虚血モニタリング用超音波センサ

    第42回日本生体医工学会東北支部大会　2008/12/13

  100. Developed Intraluminal MRI probe with Multilayer Receive Coil for High Imaging Performance

    第42回日本生体医工学会東北支部大会　2008/12/13

  101. MEMS技術を用いた医療機器開発

    第17回MAGDAコンファレンス in 日立　2008/11/20

  102. マイクロ・ナノマシニング技術を用いた低侵襲医療機器の開発（副題：体の中から治療するミクロのロボット）

    弘前高校オープン講義　2008/11/08

  103. マイクロシステムを用いた低侵襲医療機器開発

    第16回マイクロナノ先端技術交流会　2008/11/07

  104. 医療・バイオ分野におけるマイクロマシン/MEMSの現状と将来展望

    Electronic Journal 第242回 Technical Seminar　2008/10/16

  105. ＭＥＭＳのＱｏＬ応用 －健康・医療分野－

    第２回 半導体先端技術・市場動向セミナー　2008/10/15

  106. マイクロシステムを用いた低侵襲医療機器とその開発

    Medical Devices for Minimally Invasive Diagnosis and Therapy Using Micro System　2008/10/07

  107. 大学工学部の活用方法と大学発ベンチャーとの連携について

    第１回 医療機器のプロシューマ型商品開発セミナー　2008/10/04

  108. 大学工学部の活用方法と 大学発ベンチャーとの連携について

    第１回 医療機器のプロシューマ型商品開発セミナー　2008/10/04

  109. MEMSの医療分野への応用と将来展望

    電子ジャーナル主催第232回セミナー　2008/09/25

  110. 加熱機構を備えたインテリジェント鍼灸針

    生体医工学シンポジウム2008　2008/09/19

  111. マイクロシステムを用いた低侵襲検査・治療機器

    日本機械学会2008年度年次大会 オーガナイズドセッション S57 革新的診断治療　2008/08/03

  112. マイクロシステムと低侵襲医療

    リニアドライブ研究会　2008/07/01

  113. 体の中から治療するミクロのロボット ～マイクロ・ナノテクノロジーを用いた低侵襲検査・治療機器の開発～

    高大連携地域開会公開講座東北大学特別授業　2008/06/28

  114. MEMS技術を用いた医療・福祉デバイス

    第3回 MEMSPCカフェ　2008/06/27

  115. 低侵襲医療のための高機能マイクロデバイスの開発

    第47回生体医工学会大会　2008/05/08

  116. 圧電単結晶を用いた24 素子血管内前方視超音波内視鏡

    第47回生体医工学会大会,　2008/05/08

  117. 形状記憶合金コイルによる屈曲機能を備えたディスポーザブル電子内視鏡

    第47回生体医工学会大会　2008/05/08

  118. 渦電流式センサによるALS患者用速度検出型入力スイッチ

    第47回生体医工学会大会　2008/05/08

  119. 単一ファイバの電磁的振動による光走査型細径内視鏡

    第47回生体医工学会大会　2008/05/08

  120. 非平面フォトファブリケーションを用いた血管内MRIプローブ

    第47回生体医工学会大会　2008/05/08

  121. マイクロ・ナノテクノロジーを用いた新たな低侵襲検査・治療機器

    京滋呼吸器リサーチフォーラム 特別講演　2008/04/26

  122. マイクロシステムによる低侵襲医療

    北東北ナノメディカルクラスター研究会講演　2008/03/26

  123. 極細径光ファイバ圧力センサ

    未来医工学治療開発センター(TRセンター) 第1回シンポジウム　2008/03/04

  124. 極細径光ファイバ圧力センサ

    未来医工学治療開発センター(TRセンター) 第1回シンポジウム 第3部　2008/03/04

  125. マイクロ / ナノテクノロジーを用いた超精密低侵襲検査・治療機器の開発

    TUBERO終了シンポジウム　2008/02/08

  126. マイクロ／ナノテクノロジーを用いた超精密低侵襲検査・治療機器の開発

    TUBERO終了シンポジウム　2008/02/08

  127. マイクロ・ナノマシニング技術を用いた低侵襲検査・治療機器

    健康・長寿関連 新技術説明会　2007/12/19

  128. Medical applications of MEMS (Micro Electro Mechanical Systems)

    The 19th International Conference of Society for Medical Innovation and Technology (SMIT2007)　2007/11/20

  129. 多機能能動カテーテル

    芳賀洋一, 江刺正喜

    第31回日本ME学会東北支部大会　2007/11/02

  130. 医療・バイオ 関連 (カテーテル、検体検査 他)

    「MEMS集中講義」 第54回マイクロナノマシニングセミナー　2007/08/22

  131. マイクロ/ナノテクノロジーを用いた低侵襲検査・治療機器の開発

    第65回心臓血管放射線研究会講演　2007/07/28

  132. 低侵襲医療とマイクロシステム

    都市エリア産学官連携推進事業「診断治療のためのマイクロ体内ロボットの開発」研究事業　2007/03/20

  133. 医療用MEMSデバイスの現状

    芳賀洋一

    第５回多元技術融合光プロセス研究会　2007/03/15

  134. マイクロ・ナノマシニングによる先進医療機器開発

    芳賀洋一

    平成18年度次世代クラスター形成支援事業分野別研究会講演会　2007/02/13

  135. 渦電流式変位センサを用いたALS者用入力支援装置

    村川佳誕, 阿部哲也, 牧志 渉, 坂爪新一, 芳賀洋一

    第40回目本生体医工学会東北支部大会　2006/11/25

  136. Development of Medical Devices for Minimally Invasive Diagnostics and Treatment Using Micro/nano Technology International-presentation

    Y. Haga

    The 12th International Micromachine / Nanotech Symposium　2006/11/07

  137. Development of Medical and Welfare Microdevices Using Micro Technology International-presentation

    Y. Haga, T. Matsunaga, W. Makishi, K. Totsu, M. Esashi

    Proc. of the 13th International Display Workshops (IDW ’06)　2006/11/06

  138. マイクロ・ナノテクノロジーを用いた先進医療機器の開発

    芳賀洋一

    第33回日本臨床バイオメカニクス学会　2006/11/03

  139. マイクロ・ナノテクノロジーを用いた新たな低侵襲治療機器の開発

    芳賀洋一

    第11回京滋不整脈研究会　2006/10/28

  140. 極細径光ファイバ超音波受信プローブ

    石川真矢, 戸津健太郎, 中野琢磨, 芳賀洋一, 江刺正喜

    生体医工学シンポジウム2006　2006/09/23

  141. 渦電流式変位センサを用いたALS患者用入力支援装置

    村川佳誕, 阿部哲也, 牧志渉, 坂爪新一, 芳賀洋一

    福祉工学シンポジウム2006講演論文集　2006/09/11

  142. マイクロ/ナノテクノロジーを用いた超精密低侵襲検査・治療機器の開発

    芳賀洋一

    次世代医療システム産業化フォーラム　2006/08/24

  143. MEMSセミナー 医療・バイオ 関連 (カテーテル、検体検査 他)

    芳賀洋一, 西澤松彦

    MEMSセミナー　2006/08/23

  144. 低侵襲医療のための先進医工学 〜ミクロの技術が変える次世代医療〜

    芳賀洋一

    国際モダンホスピタルショウ2006　2006/07/12

  145. マイクロ・ナノ技術を用いた先進医療機器開発

    芳賀洋一

    医工連携クラスター 第1回オープンセミナー　2006/06/23

  146. MEMS技術を用いた低侵襲検査・治療機器の開発

    芳賀洋一, 松永忠雄, 牧志 渉, 戸津健太郎, 江刺正喜

    第45回日本生体医工学会大会　2006/05/15

  147. 小型収束超音波トランスデューサを用いた内視鏡的超音波治療デバイス

    安居晃啓, 芳賀洋一, 陳 俊傑, 江刺正喜, 和田 仁

    第45回日本生体医工学会大会　2006/05/15

  148. 高機能細径医療ツールのためのチューブ上への多層配線と表面実装

    五島彰二, 松永忠雄, 陳 俊傑, 牧志 渉, 江刺正喜, 芳賀洋一

    第45回日本生体医工学会大会　2006/05/15

  149. 極細径光ファイバ圧センサ

    戸津健太郎, 芳賀洋一, 松永忠雄, 江刺正喜

    第45回日本生体医工学会大会　2006/05/15

  150. 形状記憶合金コイルと磁気ラッチによる３次元ピンディスプレイ

    松永忠雄, 牧志 渉, 芳賀洋一

    第45回日本生体医工学会大会　2006/05/15

  151. Piezoelectric Resonator for Intravascular Ultrasonic Elastography

    M. Whitson, S. Omata, Y. Murayama, T. Matsunaga, K. Totsu, M. Esashi, Y. Haga

    電気学会 センサ・マイクロマシン準部門総合研究会　2006/05/15

  152. 体の中から治療するミクロのロボット

    芳賀洋一

    「もっと知りたい科学の最先端」 平成17年度 科学技術振興調整費成果発表会　2006/03/25

  153. Development of Small Diameter Ultrasound Imager for Intravascular Forward-looking Imaging International-presentation

    J.J. Chen, M. Esashi, Y. Haga

    2006 International Symposium on Nano Science and Technology　2006/03/09

  154. MEMS技術を用いた低侵襲検査治療ツールの開発

    戸津健太郎, 芳賀洋一, 江刺正喜

    第9回 ナノメディシン研究会 ・ 第3回 次世代治療技術開発のための細胞組織・分子機能の計測・制御研究会合同開催　2006/02/04

  155. 内視鏡的レーザー治療用圧電2次元マイクロスキャナー

    赤堀寛昌, 芳賀洋一, 松永忠雄, 伊関 洋, 江刺正喜, 和田 仁

    機械学会 第18回バイオエンジニアリング講演会　2006/01/13

  156. MEMSが変える次世代医療

    芳賀洋一

    セミコンジャパン2005 公開セミナー　2005/12/09

  157. ナノ・マイクロマシンの医療応用

    芳賀洋一

    第32回日本臨床バイオメカニクス学会　2005/10/28

  158. 高機能医療ツールのための円筒面フォトリソグラフィ

    五島彰二, 松永忠雄, 戸津健太郎, 江刺正喜, 芳賀洋一

    生体医工学シンポジウム2005　2005/09/27

  159. 局所ソノダイナミック治療用集束超音波プローブの開発

    芳賀洋一, 安居晃啓, 陳 俊傑, 伊関 洋, 江刺正喜, 和田 仁

    電気学会 フィジカルセンサ研究会　2005/09/22

  160. 微細加工技術を用いた 医療・福祉機器の開発と実用化

    芳賀洋一

    みやぎビジネスマーケット　2005/09/21

  161. MEMS技術を利用した 医療・福祉機器の開発

    芳賀洋一

    ナノテクキャラバン仙台 研究（シーズ）・仙台地区プロジェクト紹介　2005/07/14

  162. マイクロマシンの医療応用と大学発ベンチャーの創生

    芳賀洋一

    京都府立医科大学 大学院特別講義　2005/05/27

  163. MEMS and Related Microfabrication Technologies for Minimally Invasive Biomedical Devices International-presentation

    Y. Haga, M. Esashi

    17th International Conference of Society for Medical Innovation and Technology (SMIT2005),　2005/03/09

  164. Development of Medical Devices for Minimally Invasive Diagnosis and Therapy Using Micro/nano Technology International-presentation

    Y. Haga, M. Esashi

    Biosensors & Biomaterials Workshop 2005　2005/03/07

  165. Development of Microdevices for Minimally Invasive Diagnosis and Therapy International-presentation

    Y. Haga, T. Matsunaga, W. Makishi, M. Esashi

    ISSS 2005, International Conference on Smart Materials Structures and Systems　2005/01/28

  166. 体内における超音波治療のための収束超音波トランスデューサの開発

    安居晃啓, 芳賀洋一, 陳 俊傑, 伊関 洋, 江刺正喜, 和田 仁

    機械学会 第18回バイオエンジニアリング講演会　2005/01/13

  167. 低侵襲治療のためのマイクロマシン技術 (能動カテーテル/ガイドワイヤーとマイクロセンサシステム),

    芳賀洋一, 江刺正喜

    第１回東北大学医工学シンポジウム　2002/07/12

  168. 先端に超音波センサを搭載した能動カテーテル

    芳賀洋一, 西尾真博, 棚橋善克, 江刺正喜

    日本超音波医学会 基礎技術研究会　1999/12/01

  169. カテーテル先端の位置・姿勢を検出するMIセンサシステムの開発

    戸津健太郎, 芳賀洋一, 江刺正喜

    電気学会 センサ・マイクロマシン部門総合研究会資料　1999/11/02

  170. 電気めっきを用いた細径能動カテーテルの組み立て

    芳賀洋一, 江刺正喜

    電気学会センサ・マイクロマシン部門総合研究会資料　1999/11/01

  171. 細径能動カテーテルのための螺旋骨格薄肉チューブの開発

    芳賀洋一, 前田重雄, 江刺正喜

    電気学会センサ・マイクロマシン部門総合研究会資料　1999/11/01

  172. 能動カテーテル (Active Catheter)

    芳賀洋一, 江刺正喜

    第38回日本エム・イー学会大会論文集　1999/04/21

  173. ねじれ回転機構を持った能動カテーテル

    芳賀洋一, 江刺正喜

    第38回日本エム・イー学会大会論文集　1999/04/21

  174. 能動カテーテルのための前方視リングアレイ超音波プローブの試作

    谷 恵亮, 西尾真博, 芳賀洋一, 江刺正喜

    第38回日本エム・イー学会大会論文集　1999/04/21

  175. フレキシブル配線を用いた超音波素子のカテーテル先端への実装

    谷 恵亮, 鈴木 学, 芳賀洋一, 江刺正喜

    第16回「センサ・マイクロマシンと応用システム」シンポジウム講演概要集　1998/10/01

  176. 先端に微小ダイヤフラム構造を持つ極細光ファイバ圧力センサ

    勝間田 卓, 芳賀洋一, 南 和幸, 江刺正喜

    第37回日本エム・イー学会大会論文集　1998/05/01

  177. ブラッググレーティングを形成したフレキシブル光導波路によるカテーテル用分布型曲がりセンサ

    富吉俊夫, 芳賀洋一, 南 和幸, 江刺正喜

    第37回日本エム・イー学会大会論文集　1998/05/01

  178. 多機能能動カテーテル

    芳賀洋一, 朴 起台, 勝間田 卓, 富吉俊夫, 江刺正喜

    第37回日本エム・イー学会大会論文集　1998/05/01

  179. ウエハプロセスで作製した能動カテーテル用のシリコン多関節構造

    峯田 貴, 渡部善幸, 小林誠也, 芳賀洋一, 江刺正喜

    平成10年電気学会全国大会講演論文集　1998/03/01

  180. 形状記憶合金による能動屈曲機構を備えた細径超音波内視鏡

    芳賀洋一, 棚橋善克, 江刺正喜

    日本超音波医学会第70回研究発表会　1997/11/01

  181. A Study of Smart Active Catheter International-presentation

    朴 起台, 芳賀洋一, 江刺正喜

    KIEE 97 Annual Summer Conference　1997/07/02

  182. Active Catheter Using Polymer Links International-presentation

    芳賀洋一, 朴 起台, 江刺正喜

    9th Annual International Meeting, Minimally Invasive therapy & Allied technologies　1997/07/01

  183. 光ファイバ圧力センサの基礎実験

    芳賀洋一, 南和幸, 仁田新一, 田中元直, 江刺正喜

    第27回日本ME学会東北支部大会　1993/11/01

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Industrial Property Rights 23

  1. 脳べらおよびセンサユニット

    芳賀 洋一, 森田 明夫, 原田 香奈子, 松永 忠雄, 川端 友徳, 鶴岡 典子

    Property Type: Patent

  2. 光ファイバ走査装置、内視鏡および光ファイバ走査装置の製造方法

    芳賀 洋一, 松永 忠雄, 李 宣

    Property Type: Patent

  3. デバイス及びデバイスの製造方法並びにアレイ型の超音波プローブの製造方法

    鈴木 大地, 不破 耕, 前平 謙, 大橋 靖知, 藤田 勝博, 芳賀 洋一, 松永 忠雄

    Property Type: Patent

  4. センサ付きカテーテル

    芳賀 洋一, 松永 忠雄, 齋木 佳克, 橘 侑子, 添田 誠, 深谷 昌宏

    Property Type: Patent

  5. アクチュエータ、アクチュエータの製造方法

    芳賀 洋一, 小林 拓生, 松永 忠雄

    Property Type: Patent

  6. 神経電極システム

    芳賀 洋一, 松永 忠雄, 玉置 俊輔, 小山内 実, 虫明 元, 大城 朝一

    Property Type: Patent

  7. 発散量測定装置

    芳賀 洋一, 河野 隆宏, 鶴岡 典子, 松永 忠雄

    Property Type: Patent

  8. 挿入器具および挿入器具の製造方法

    芳賀 洋一, 松永 忠雄

    Property Type: Patent

  9. 送液装置および送液システム

    芳賀 洋一, 松永 忠雄, 永富 良一, 鶴岡 典子

    Property Type: Patent

  10. 点字ピン駆動装置

    江刺 正喜, 芳賀 洋一

    特許第3624785号

    Property Type: Patent

  11. 圧力センサおよびその製造方法

    江刺正喜, 芳賀洋一, 勝間田卓

    特許第3393370号

    Property Type: Patent

  12. 能動導管とその製造方法

    江刺正喜, 芳賀洋一

    特許第3477570号

    Property Type: Patent

  13. デバイス及びデバイスの製造方法並びにアレイ型の超音波プローブの製造方法

    鈴木 大地, 不破 耕, 前平 謙, 大橋 靖知, 藤田 勝博, 芳賀 洋一, 松永 忠雄

    特許第6265578号

    Property Type: Patent

  14. 能動チューブ駆動装置

    江刺正喜, 芳賀洋一, 水島昌徳, 松永忠雄

    特許3944651

    Property Type: Patent

  15. 能動チューブおよび能動チューブシステム

    江刺正喜, 芳賀洋一, 水島昌徳, 松永忠雄

    特許3852033

    Property Type: Patent

  16. 超音波振動子及びその製造方法

    江刺正喜, 芳賀洋一, 水島昌徳, 松永忠雄

    特許第3787725

    Property Type: Patent

  17. 走査ミラー、ビーム走査型プローブ

    江刺正喜, 芳賀洋一, 前田真法, 菊地直樹

    特許3934578

    Property Type: Patent

  18. 形状記憶合金を用いた駆動装置及びそれを用いたディスプレイ装置並びにそれらの製造方法

    江刺正喜, 芳賀洋一, 水島昌徳, 松永忠雄

    特許第3684552号

    Property Type: Patent

  19. 形状記憶合金の接合構造及びその接合構造形成方法

    賀洋一, 江刺正喜

    特許第3814723号

    Property Type: Patent

  20. 前方視超音波探触子及びその製造方法

    藤田 匡佑, 芳賀 洋一, 江刺 正喜

    特許第3553923号

    Property Type: Patent

  21. 形状記憶合金パイプ型アクチュエータ及びその製造方法

    峯田 貴, 江刺 正喜, 芳賀 洋一

    特許4003164

    Property Type: Patent

  22. 光ファイバ端面のマイクロレンズの形成方法

    江刺 正喜, ファン ミン, 芳賀 洋一

    特許3921556

    Property Type: Patent

  23. 能動細管及びその製造方法

    江刺正喜, 芳賀洋一

    特許4096325

    Property Type: Patent

Show all Show first 5

Research Projects 28

  1. 非平面光導波路搭載針を用いた複数物質同時計測による極低侵襲エネルギー代謝モニタ

    鶴岡 典子, 芳賀 洋一, 松永 忠雄

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

  2. Development of 3D acoustic CT with multi-channel phonocardiogram for lung lesion detection

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07/09 - 2023/03/31

  3. 皮膚微小還流針による極低侵襲乳酸動態モニタリング

    鶴岡 典子, 芳賀 洋一, 永富 良一, 川副 友

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    本研究では、皮膚微小還流を応用し、乳酸濃度の連続測定を可能とする。さらに、これまで数分毎の計測からしか推定できなかった、マウスおよびヒト運動時の乳酸濃度動態を明らかとすることを目的として研究を進めている。 開発する乳酸計測システムは、極細径で痛みのない針を1 mm程度の浅い皮膚に刺入しただけで計測が可能なため、生活習慣病予防のための運動の習慣化に役立つだけでなく、術後の虚血モニタや敗血症の兆候モニタなどにも応用が期待される。 本研究では、非観血的な乳酸連続計測を目指し、皮膚微小還流による計測システムを完成させ、運動時の乳酸濃度動態を明らかとする。具体的には ①連続乳酸計測システムの作製と性能評価、② マウス腹腔乳酸投与前後での乳酸濃度変動計測による血中乳酸濃度との相関性評価、③ マウス運動時の連続乳酸濃度計測、④ ヒト運動時の乳酸濃度計測の4つの項目を行っていく。これと同時に、運動負荷計測の応用だけでなく、虚血のモニタや敗血症防止、筋中乳酸計測への応用など本研究の展開を模索する。 本年度はこれらの中で①連続乳酸計測システムの作製と性能評価について引き続き開発を進めた。従来作製してきたシステムでは、還流の際に気泡混入が問題となっており連続的な測定が実現できていなかった。当該年度では、これらの気泡混入の条件を明らかとし、前年度問題であった気泡除去の際の流速変化を改善できる、気泡除去機能付きセンサ部を完成することができた。今後はこのセンサ部を用いた連続的な濃度変化の計測を目指す。

  4. 体内における細胞組織精密操作技術の開発

    芳賀 洋一, 明石 真, 鶴岡 典子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    本研究では、①低侵襲医療機器に搭載可能な、極低侵襲にRNA、細胞を採取する機器の基礎開発、②動物実験による開発した機器を用いた体内局所から採取した細胞の分析評価、③細胞デリバリーデバイスとシステムの提案および試作評価、を行う。 当該年度は、細胞組織を一定時間ごとに分離する機器の設計と開発および評価を行った。肝臓や腎臓の様な充実性臓器および粘膜組織のように切離に代表される物理的な組織への働きかけによる分離・採取を行うそれぞれの部位における手法と機器について、複数回採取における前後の細胞採取のコンタミネーションを避けるため、１回の採取ごとに使い捨てとする必要性から、生検鉗子類似の機構を１回のプロセスで複数個、一括作製する構造と作製方法を確立し、試作評価を行った。血液のような細胞を含む液体の一定時間ごとの採取のための手法と機器、脳組織のように機器の刺入と吸引を用いることで細胞組織の分離と採取を一定時間ごとに行う手法と機器について、できるだけ共通の手法と機器設計にすることを念頭に手法の提案と設計を行い研究開発が多様化し過ぎて分散しないようにしている。補助手段における超音波を用いる方法として鉗子類似機構の近くに超音波素子を配置する設計と作製方法を具体的に検討している。各種組織を模したモデルを用いた評価を行ったが、新型コロナウイルス感染症対応に伴い、充分な研究実施時間を確保できなかったため、当初の予定から、やや遅れている。

  5. Ultra-sensitive real-time MRS probe using high-field MRI

    MATSUNAGA Tadao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    2018/04/01 - 2021/03/31

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    An intraluminal magnetic resonance imaging (MRI) probe holds promise to achieve a higher resolution image of a small pathological lesion than conventional external probes. Such an intraluminal probe requires precise resonant frequency tuning to 500 MHz and impedance matching to 50 Ω, if used for instance in a 11.7-T scanner which can realize a real-time bio-imaging. Designed coil which has higher self-resonance frequency has been fabricated utilizing our developed non-planar photofabrication techniques, and an electrical characteristic has been evaluated. Measured self-resonant frequency of the MRI coil was around 800 MHz and it is higher enough to realize a higher resolution MRI.

  6. Electromagnetic scanning forward viewing ultrasound endoscope equipped in a guide wire

    Yoichi Haga

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    An electromagnetic scanning forward viewing ultrasound thin endoscope intended to be equipped in a guide wire has been developed for intravascular treatment. The endoscope consists of a resonator with an ultrasonic transducer and a driving coil. Driving of the electromagnetic resonator was confirmed using the driving coil, 50 um witdth silicon beam and a cylindrical shaped samarium cobalt magnet. Almost element technology has been established for fabrication of the device and equipment in the guide wire and ultrasound imaging will be realized by packaging in thin and small size.

  7. Research for improvement of local CNS drug delivery system and its generalization

    Saito Ryuta

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    Recently, we have been working towards CNS (central nervous system) drug delivery system that enables effective distribution of the infusate. Aiming at improved and stable drug delivery system, we developed ultrasound facilitated drug delivery (UFD) device that achieve improved distribution in brain parenchyma. In this study, in order to improve the system, we developed pressure-controlled microinfusion pump. We demonstrated that our system enabled constant pressure delivery within +/- 1mmHg pressure range. Second generation UFD device was also fabricated for stable delivery. Subsequently, to prove that our device is applicable to multiple CNS diseases, we attempted to deliver therapeutic agents to epilepsy model, spinal disease model, and Alzheimer disease model. Anti-epileptic agents worked in epilepsy model, chemotherapeutic drug worked in spinal tumor model. Both of these headed for publication of the literature.

  8. Thin film magnetic field sensor inside body at room temperature

    YABUKAMI Shin, HAGA Yoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku Gakuin University

    2013/04/01 - 2016/03/31

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    A very sensitive thin film sensor was developed using a meandering coplanar line fabricated from SrTiO film (3 μm thick), amorphous CoNbZr film (1.0 mm x 2.45 mm, 0.3 μm-2 μm thick) and Cu/Cr film (2 μ m/0.1 μm). The deposited SrTiO film enhanced the sensitivity of a magnetic field sensor, a phase change of more than 300 degrees/Oe being achieved. The maximum phase change (sensitivity) was observed for a CoNbZr film thickness of around 0.5-1 micro m. The optimum CoNbZr film thickness was realized by the tradeoff between the sensitive bias field and the volume of the CoNbZr film. A sensor module was composed of meandering sensor element and commercial IC. A resolution of about 100 pT was obtained the module. We succeeded in wireless magnetic field measurement using the sensor module.

  9. Development of a new catheter for segmental adrenal venous sampling

    Seiji Kazumasa, Takase Kei, Morimoto Rei, Oota Makoto, Haga Yoichi, Nakamura Yasuhiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

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    Segmental venous sampling is essential for diagnosis and localization of aldosterone producing adenomas. In segmental adrenal venous sampling (S-AVS), blood samples are obtained with microcatheters inserted into the target venous tributary. However, it sometimes happen that blood samples cannot be obtained through catheters. In such cases, it is assumed that suction pressure deforms venous wall, then catheter tip is considered to be occluded. To our knowledge, there has been no study concerning hemodynamics in venous catheter blood sampling. The purpose of this study is to simulate the blood flow in venous blood sampling using synthetic very small blood vessel or Computational Fluid Dynamics method and to search the catheter tip shape suitable for the procedure. The prototype of microcatheter whose tip was shaped suitable for S-AVS was created. And then, the performance of the microcatheter was evaluated in an animal study.

  10. Electrical and fluidic functionalized implantable elastic tube

    HAGA Yoichi, MATSUNAGA Tadao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

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    Non-planar micromachining utilizing photofabrication techniques was developed for realizing electrical and fluidic functionalization of tube for use in the human body. Protrusion metal structures were fabricated on concave surfaces of a ceramic substrate by making protrusion on the concave surfaces and subsequent electroplating of metal layers. Fluidic channels have been also fabricated on the concave surfaces. Electrodes and non-conductive layers were fabricated on a polymer tube with a diameter of 0.4 mm and perforated windows were made using laser ablation for connecting inside of the tube and outside of the tube. Polymer multilayer tubes with pleural electrodes located inside the wall were fabricated using vapor deposited polymer as wall material for realizing thin-walled soft structure.

  11. Development of the stiffness sensor using ultrasonic pulse-echo for myocardial protection during cardiac surgery

    SHIBUYA TAKUMI, HAGA Yoichi, MATUNAGA Tadao, SAIKI Yoshikatsu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    Ischemic myocardial contracture (stone heart) occurs, if myocardial protection is not appropriate during cardioplegic arrest. For quantitatively monitoring a condition of myocardial protection, we have developed the stiffness sensor. To measure myocardial stiffness, negative pressure is applied to the myocardium through the probe and displacement of myocardial surface is quantified using ultrasonic pulse-echo. In the future, we would evaluate this sensor in animal experimental models, and provide the cardiac surgery for clinical applications.

  12. Development of minimally-invasive interventional radiological therapy of primary aldosteronism based on adrenal venous sampling.

    TAKASE KEI, OOTA Makoto, MORIMOTO Ryou, SEIJI Kazumasa, SATOU Fumitoshi, SATOU Miho

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

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    Real-size vascular model including adrenal venous tributaries was generated, which was utilized for simulation of catheterization. Experimental study using bovine adrenal gland showed that 3 insertion patterns of bipolar needles enables complete ablation of adrenal adenoma with 10 to 25-mm in diameter. Adjacent organ with 5-mm intervening adipose tissue was preserved. Initial clinical interventional radiological treatment achieved normalization of plasma aldosterone level and amount in 24-hour urine specimen. Cost-effectiveness of this treatment was also proven.

  13. Intra-corporeal MRI/NMR probe using non-planar photofabrication

    HAGA Yoichi, KURODA Kagayaki, SAIKI Yosikatsu, MATSUNAGA Tadao, MATSUOKA Yuichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2011/04/01 - 2014/03/31

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    The purpose of this research is realization of high-resolution imaging of local area tissue in the human body using an intra-corporeal MRI/NMR probe fabricated using photoresist pattering and Cu electroplating on the cylindrical substrate. Performance of imaging is improved by multilayered coil pattern fabricated by repeating the process after coating of nonconductive layer. Small size integrated circuits of variable capacitor which can compensate frequency shift by tissues around the coil have been designed and fabricated. Signal receiving of NMR signal was confirmed and image estimation was performed using the mounted circuit on the probe. Receiving NMR signal and imaging without electric breakdown of the integrated circuit was realized using developed protecting circuit.

  14. Development of an artificial intestinal mucosa

    FUKUSHIMA Kouhei, HAGA Yoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2010 - 2011

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    We tried to construct"artificial intestinal mucosa", which is composed of villus-and crypt-like structures, using micro electric mechanical systems (MEMS), which are utilized for creating 3-demensional micro-constructs. We successfully made"small intestine"-like structures featured by multiple projections on the surface and"colon"-like structures with multiple hollows. We covered the irregular surface with the artificial membrane on the structures and cultured epithelial cells. We might generate an artificial mucosa by inventing a new system enabling exchange of molecules between epithelial cells and cells under basal membrane.

  15. Development of drug delivery system for central nervous system

    TOMINAGA Teiji, HAYASE Toshiyuki, HAGA Youichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2009 - 2011

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    This study aimed at developing novel brain interstitial drug delivery system for the treatment of central nervous system disorders. Recently we performed basic and clinical study using convection-enhanced delivery (CED). Convection-enhanced delivery (CED) is a local infusion technique that delivers various molecules to the central nervous system. We firstdeveloped real-time MRI guided monitoring system. In this system, we infuse the mixture of chemotherapeutic agent; ACNU with Gd-DTPA for real-time monitoring using MRI. Subsequently, we developed computational simulating system that predicts the distribution of Gd-DTPA in a brainstem of non-human primate. In addition, we developed a novel drug delivery apparatus.

  16. Next Generation Therapeutic Devices for Deflectable Endoscope

    HAGA Yoichi, MATSUNAGA Tadao, ESASHI Masayoshi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2008 - 2010

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    Multifunctional endoscope and device which is attached at the tip of endoscope have been developed. A bending transformative endoscope has been developed to solve limitation of small incision or a natural body opening for insertion of the endoscope using non-planar photofabrication process and laser machining.

  17. Development of oxygen saturation analysis system applicable to deep solid organs

    SAIKI Yoshikatsu, KAWAMOTO Shunsuke, TABAYASHI Koichi, HAGA Yoichi, MATSUNAGA Tadao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2008 - 2010

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    We attempted to invent a microphotodetector system to enable us to monitor oxygen saturation on the solid organs located away deep from the body surface by use of MEMS technology. We aligned two photodetectors in a side by side fashion and optical fibers with maximal coherence for both emitting and detecting function. First generation prototype for that purpose was created, and further modifications have been made.

  18. Development of a novel monitoring system for spinal cord ischemia

    SAI Sadahiro, SAIKI Yoshikatsu, MOTOYOSHI Naotaka, HAGA Yoichi, MATSUNAGA Tadao, KAWAMOTO Shunsuke

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2007 - 2010

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    We created a novel device consisted of micro-flow sensor element and transmitting/receiving circuit to detect spinal cord ischemia. The sensor unit could detect Doppler shift generated by artificial blood flow within a vascular phantom mimicking Adamkiewicz artery. Further modifications are warranted to improve S/N ratio before we introduce the catheter into the clinical arena.

  19. 円筒面フォトリソグラフィーを用いた光ファイバー電磁振動型細径高精細内視鏡の開発

    芳賀 洋一, 松永 忠雄, 牧志 渉

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2006 - 2007

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    1本の光ファイバーを電磁的に2次元スキャンさせ画像を構成する原理を用い、細径かつ解像度の高い医療用内視鏡の実現を目指した。血管内、乳管内、歯周ポケットなどへ挿入し光学的観察を行うことを想定している。外径2mmのポリイミドチューブを基板とし、円筒面上へのフォトリソグラフィーと銅の電解めっきにより2次元駆動のための多層コイルを作製した。円筒状基板へのフォトリソグラフィーは、露光光としてレーザ光をスポットで照射し、基板をステージ制御で動かすレーザ描画で行う。スプレーコーターでレジストを均一な膜厚で塗布し、レーザ描画露光装置を用いてコイル形状をパターニングする。その後レジストを型として電解めっきを行いコイルの作成を行った。光ファイバーを電磁的に駆動し振動させるため、永久磁石を取り付けたコリメートレンズ付き光ファイバーをコイル内に内蔵する。永久磁石は、外径500μm、内径140μm、長さ2mmのFe-Cr-Co系永久磁石を使用した。また、コリメートレンズは外径125μmで長さ790μm、焦点距離750μmのファイバー融着型グリンレンズを使用した。コイルに交流電流を流すと永久磁石の磁気モーメントが磁界と揃うように曲がり光ファイバーを振動させる。X,Yそれぞれの1次元の駆動および、X方向とY方向の位相を90度ずらした状態で正弦波振動させ円を描き、2次元駆動を確認した。

  20. 高機能細径医療ツールのための円筒面に適したMEMSプロセスの開発

    松永 忠雄, 芳賀 洋一, 牧志 渉, 江刺 正喜

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2006 - 2007

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    本研究の目的は、マスクレス露光を用いたフォトリソグラフィーをはじめとする半導体微細加工技術および微小機械要素を取り入れたMEMS技術を、細径の円筒面に適応することにより、高機能医療ツールを実現することである。医療機器など高付加価値のデバイスの形状に着目すると、ほとんどが円筒形状であり、この目的に特化して新たな微細加工および集積化技術を開発することにより、今までにない有用で高機能なデバイスを実現できる。昨年度から遂行している円筒形状サンプル表面にフォトリソグラフィーを行うための要素技術(露光、レジストスプレーコーティング、成膜、めっき)、および非平面サンプル上へのレーザー局所加熱を用いた集積回路実装技術はほぼ確立した。 本年度は露光光を微小点で照射し,ステージを多軸で制御することにより描画する点照射を用いたマスクレス露光により、血管内MRIプローブの作製を行った。本デバイスは血管病変をコントラスト良く高解像度イメージングするために用いられる。外径φ2mmのガラスチューブ上にサドルコイル(RFコイル)を作製し、マッチング回路を組み込みこんだデバイスをMRI装置に接続し、イメージングを行った。ブタ鎖骨下動脈摘出サンプル内に本デバイスを挿入しイメージングを行った結果、φ7.5mm範囲の撮像が可能であり、その有効性を確認した。 以上の結果から、円筒面に適したMEMSプロセスを用いた高機能細径医療ツールのフィージビリティを確認し、本研究の目的をほぼ計画通り達した。

  21. ISFETを用いた膵管内PHモニタの作成と膵炎、膵癌の早期診断への応用

    佐藤 賢一, 芳賀 洋一, 木村 憲治

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 東北大学

    2004 - 2005

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    膵癌は手術後の5年生存率が20%以下と消化器癌のうちで最も予後不良の癌の一つである.両疾患とも早期発見によって、それぞれ膵機能不全の防止ならびに手術による根治術の可能性が高まる.しかし、現在までに早期発見の切り札となる検査法は確立されていない. 膵導管のわずかな異常部位を同定する事ができれば慢性膵炎の初期の段階を捉える可能性がある.同様に膵癌は末梢の導管から生ずるため、その発生初期の段階で局所的に導管機能の低下が起こっており、早期の状態ではその障害の為血清アミラーゼの上昇も認められる。この事から、膵管内の局所で膵液中の重炭酸塩濃度を測定できれば、両疾患の早期発見も現実的となる. "ISFET(Ion Sensitive Field Effect Transistor)"は、超小型の半導体で、幅約0.5mm以下と非常に小さく、シャーペンの芯ほどの大きさでpHを測定することができる。さらに微量な検体量で測定可能である点が特徴である.重炭酸塩は弱アルカリ性でありその濃度の変化はpHの変化を引き起こす.そこで、本研究では、ISFETを利用して、膵管内のpHをモニターし、慢性膵炎さらに膵癌の早期診断に対する応用を検討する事を目的とした. 本研究において、準備段階である膵癌発がんマウスモデルを樹立した。すなわち、化学物質DMBAをマウス膵に直接投与することによって、3ヶ月以内に高頻度に膵癌が発生することを明らかにした。このモデルを使い、今後膵管内pHを測定し癌化との関連を明らかにしていく予定である。

  22. Development of intrauterine endoscopic surgical tools at early stage during pregnancy

    HAGA Yoichi, ESASHI Masayoshi, CHIBA Tashio

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2002 - 2004

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    Surgery of fetus and embryo is being shifted from open fetal surgery to fetoscopic procedure. In this research, several endoscopic surgical tools have been developed for intrauterine endoscopic surgery at early stage during pregnancy, for example, ultrasonic endoscope for observation of fetus and embryo, micro laser scanning tool and focused ultrasonic probe as treatment tools. For precise laser treatment in uterus, a 2D (two dimensional) laser scanning micro tool has been developed. The tool is made up of an optical fiber, a micro rod lens and a 2D microscanner. The 2D microscanner has three piezoelectric unimorph cantilevers. The mirror is supported by a pivot from underside and is inclined by pushing down by three cantilevers on the top of the mirror. Scanning of 100-um-diameter spot of KTP laser was confirmed. For insertion the tool into a working channel of a conventional endoscope, these components are packaged into a 3.8-mm-external-diameter polymer tube. As ultrasonic tools, convex-shaped 8 ring array ultrasonic imager of 3-mm-diameter and concave-shaped ultrasonic transducer for ultrasonic treatment have been developed. Each transducer of the imager can detect echo signal from an aluminum board in water. Imaging of tissue in the fetus / embryo will be tested. A 6-mm-diameter ultrasonic treatment tool has been fabricated and power generation of ultrasound at intensity for treatment was confirmed.

  23. Distributed Micro-Nanomachines which move with nanometer precision

    ESASHI Masahi, TANAKA Shuji, ONO Takahito, HANE Kazuhiro, HAGA Yoichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2001 - 2003

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    Nanostructures have been studied to develop distributed micro-nanomachines which are integrated systems of sensors and actuators. Micromachining based on semiconductor technology has been applied for the fabrication. High density multi probe data storage systems in which recording and reading can be carried out in parallel utilizing arrayed probes. New recording principles have been developed. These are thermomechanical recording on a thin polymer film using diamond probes, electrical recording on a thin ferroelectric film using diamond probes and electrical recording on a thin conductive polymer film. In the latter recording on a conductive polymer film, increased resistance about 30 times by the phase change of the film was used for the reading. Arrayed electron field emitters with electrostatic lens was studied for the purpose of non-contact multi probe data storage systems and multi-column electron beam lithography systems for the purpose of high throughput patterning. Carbon nano tube and diamond are used as the emitter and it was proved that surface coverage of the carbon nano tube with hydrogen enhances the electron emission and reduces the noise of the emission current. Monolithic piezoelectric stage which has 6 degrees of freedom of motion was developed. This is needed not only for the multi probe data storage systems and the multi-column electron beam lithography systems but also scanning probe microscopes and so on. Distributed electrostatic actuators which have sub-micro gap face to face parallel electrodes, multi probe system of which probes can move with electrostatic micro actuator, near-field optical prove which has bow tie antenna and highly sensitive resonant sensor which is made of nanometer level thin cantilever.

  24. 形状記憶合金コイルを用いた視覚障害者用ピンディスプレイ

    芳賀 洋一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 東北大学

    2000 - 2001

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    1,1文字(8ピン)単位のモジュール化と設計の最適化:点字を動的に表示するために8ピンを1つのモジュールにまとめて1文字とし、抜き差しによる交換を可能にして故障の際のメンテナンスに対応した。また、ラッチ機構(永久磁石、ニッケルチューブ、金属板)の最適化を行い、ラッチ力およびピンの動作特性を向上した。 2,形状記憶合金(SMA)コイルアクチュエータ駆動用ICのモジュールへの搭載:ひとつひとつのモジュールにアドレッサブルラッチ(74HC259)とトランジスタアレイ(TD62083)を搭載し、外部回路から簡単に制御できるようにした。ICを載せる回路基板を設計・自作することによりモジュール全体を小さくし、点字の規格に合わせて集積化して配列できるようにした。また、複数のモジュールを一括して制御する回路を作製し、ピンの上下動作制御を確認した。 3,電気めっきを利用した一括組み立て:それぞれのピン上のSMAコイルと回路基板を電気的に接続するために従来は導電性接着剤を用いていたが、ニッケルの電気めっきを局所的に行う技術を開発し、モジュールの一括組み立てを可能にした。 4,2次元配列ピンディスプレイの設計・開発:盲人用の点字を動的に提示するピンディスプレイはモジュールを横一列に16〜32個並べているが、縱横2次元平面にピンを分布させることができれば図形も表現できる。この目的のため制御用ICをピンの真下に配置させた設計を考案し基板の設計・試作を行った。

  25. Multi-functional Active Catheter

    ESASHI Masayoshi, NITTA Shinichi, LIU Lng xun, HAGA Yoichi, FUSHIMI Masahiro, TAKAHASHI Akira

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A).

    Institution: Tohoku University

    1998 - 2000

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    Active catheters which can move in a blood vessel and reach some part in a body(for example inside a brain) have been developed for the purpose of diagnosis and therapy in a blood vessel. Micromachining based on a semiconductor micro fabrication has been applied for their fabrication. Many actuators made of shape memory alloy(SMA) coil rare distributed in the active catheter and hence it can bend flexibly like a snake. Sensors for the catheters have been developed as well. Active catheters(2.3 mm in outer diameter) having integrated circuits for communication and control and hence needs only three common lead wires have been developed. Multi-functional active catheters( 1.4 mm in outer diameter) which can not only bend but also extend and twist have been also developed. The Multi-functional active catheters have been fabricated in batch process using electroplating and other processes. Furthermore active guide wires(0.5 mm in outer diameter) have been fabricated using etched thin SMAplate. Thin outer tube having liner coil was fabricated for the active catheter. Sensors for the active catheters have been developed. One is a forward looking ultrasound imager (3 mm in outer diameter)at the end of the active catheter to assist their navigation. Thermal micro relay as a multiplexer for the transmitting ultrasonic pulse has been developed. Micromachining of a piezoelectric material(PZT) has been studied. Silicon lost mold process for the PZT which uses micromachined silicon as a mold for sintering was developed and achieved piezoelectric characteristics successfully. Fiber optic fine(125 μm in outer diameter) pressure sensor which has a thin diaphragm at the end of a optical fiber was fabricated by applying silicon deep reactive ion etching(RIE). Three axis magnetic field sensor was fabricated at the end of en active catheter was fabricated to know the position and the direction of the catheter tip in the body. Laser assisted chemical vapor deposition(CVD) using ultraviolet CW laser was developed for micro assembly and selective metalization. These research results presented in a conference for the therapy inside brain blood vessel were highly evaluated by medical doctors.

  26. Joint Research on Micro Fluid Control System

    ESASHI Masayoshi, TANAKA Shuji, HAGA Yoichi, ONO Takahito, MINAMI Kazuyuki, LIU Lyong xun

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B).

    Institution: Tohoku University

    1998 - 2000

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    Micro fluid control systems which have integrated flow sensors, valves, pumps and flow channels are needed for different applications. Silicon micromachining which can integrate sensors and signal processing circuits and micro molding for mass production of disposable plastic microstructures can be used to fabricate micro modules for micro fluid control systems. Sampling module which uses surface tension for controlling the mixing of sample solution and reagent chemicals have been developed for chemical analyzing systems. Surface tension plays important roles in this system. To control hydrophobic properties of the surface, pulse co-electroplating of Teflon and nickel was successfully developed. Micro molding technology has been studied for the mass-production of disposable plastic module for analyzing small volume blood sample. Micro molds were fabricated by deep reactive ion etching (RIE) of silicon or using numerically controlled high speed milling machine in Tohoku University and the molding by hot embossing was carried out in Friburg University in Germany which is the collaborator in this project. In addition, micro molding using UV curable resin and UV transparent silicone rubber mold were developed. Immuno-reaction chip which has micro colume has been also fabricated. DNA chips which can be used for low cost parallel DNA diagnosis were developed by synthesizing different DNA probe photrolithographycally on a silicon chip. DNA chip for detecting SNP of cancer promoter is being developed based on the DNA chip. Spotting head for DNA chip was also fabricated. Integrated mass flow controller for corrosive gases was developed for fine gas control in sophisticated semiconductor processes. Stainless steel and aluminum nitride are used as the materials because of their inertness to halogen gasses as fluoride and chloride.

  27. マイクロマシニングを用いた前方視血管内超音波内視鏡

    芳賀 洋一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 奨励研究(A)

    Institution: 東北大学

    1997 - 1998

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    1、 撮像プログラムの作成と像構成 あらかじめ発信振動子と受信振動子のすべての組み合わせの反射波形を測定し、各ピクセルに対応した遅延時間をソフトウェア上で加え重ね合わせる、ソフトウェア式フェイズドアレイプログラムを作成した。 2、 撮像実験およびコンポジット型PZTリングアレイ超音波プローブの作製 外径φ3mm、内径2mmの8素子のPZTリングアレイ超音波振動子を用いてデータ取得を行い、上記の撮像プログラムを用いてプローブ正面に置いたφ1mmの真棒およびφ3mmのボールベアリングの撮像を行った。撮像物体の像および移動の様子が確認されたが、超音波パルスのリンギングおよび不要な振動モードに起因すると思われる多数の虚像が同時に観察された。そこでDice and Fill法によりリング状の1-3コンポジット素子を新たに作製し、リンギングの若干の減少と不要な振動モードの除去を確認した。 3、 ファインピッチ1-3コンポジット型超音波振動子作製プロセス 虚像のないより鮮明な画像を得るためにはPZTの1-3コンポジットをより微細に作る必要がある。RIE(反応性イオンエッチング)によるディープエッチングを行ったシリコンを鋳型にしてPZTを焼結するSi-lost-mold法を改良し、φ7μmのPZTロッドのアレイを試作した。 4、 RIEを用いたPZT加工法の開発 ファインピッチ1-3コンポジットを作製するための新たなPZT加工法として、RIE(反応性イオンエッチング)で直接PZT基板をエッチングする方法を開発した。これは、SF6ガスのプラズマ中で発生したイオンに電界をかけて加速し、PZT基板に衝突させるもので、あらかじめパターニングしたNiマスクのない場所でPZTが選択的に取り去られる

  28. Joint study on high performance resonant sensors

    ESASHI Masayoshi, SCHMIDT M.A, SENTURIA S.D, ONO Takahito, HAGA Yohichi, KURABAYASHI Toru, MINAMI Kazuyuki, ROOIJ N.F.de

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for international Scientific Research

    Institution: TOHOKU UNIVERSITY

    1995 - 1996

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    In this study, the developement of novel micromachining processes and the fabrication of resonant sensors were done. Summary is as follows. 1. For making high sensitive micro resonator, the process for fabricating thin cantilever having an opposed electrode with a very narrow gap for SPM application was established. Thickness of the silicon cantilever and the gap between the cantilever and a glass substrate were less than 1mum. The novel drying method was developed for avoiding stiction by the surface tension force of liquid. 2. Vacuum packaging of micro resonator was studied for realizing high Q factor. Damping by gas molecules degrade the Q factor of the micro resonator. Vacuum packaging method using glass-silicon anodic bonding and non-evaporable getter was developed and applied to the sensor fabrication. 3. A silicon resonant angular rate sensor using electrostatic excitation and capacitive detection was developed. For this device, driving and detection circuit, self oscillation circuit, and detective resonant frequency stabilizing circuit for electrostatic servo were realized. 4. A silicon resonant angular rate sensor using electromagnetic excitation and capacitive detection was developed. Packaged sensor was work and had high Q factor. For the fabrication this sensor, a new type reactive ion etching system was developed. 5. Novel process for making thin and narrow silicon beam of resonators was developed. By this process using XeF_2 dry etching and thermal SiO_2, a silicon beam having 60mum square cross-section beam was realized. 6. Piezoelectric excitation method for large amplitude vibration was studied. Deposition method of piezoelectric thin film largely affected the piezoelectric properties. Deposition method should be investigated in future.

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Social Activities 13

  1. イベーション・ジャパン 2006

    2006/09/13 - 2006/09/15

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    出展タイトル：東北大学先進医工学研究機構芳賀研究室(マイクロ・ナノマシニング技術を用いた低侵襲検査・治療機器)

  2. 国際モダンホスピタルショウ2006

    2006/07/12 - 2006/07/14

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    国際モダンホスピタルショウ2006、東京ビッグサイト 出展タイトル：東北大学先進医工学研究機構 芳賀研究室 (主催：社団法人 日本病院会、社団法人 日本経営協会)

  3. ナノバイオExpo2006、東京ビッグサイト

    2006/02/21 - 2006/02/23

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    ナノバイオExpo2006、東京ビッグサイト (メムザス株式会社と共同出展) (出展タイトル：マイクロ・ナノマシニング技術を用いた低侵襲検査・治療機器)

  4. メディカルクリエーションin福島

    2005/01/24 - 2005/11/24

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    メディカルクリエーションin福島、ビックパレットふくしま

  5. イノベーション・ジャパン2005 大学見本市、東京国際フォーラム

    2005/09/27 - 2005/09/29

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    イノベーション・ジャパン2005 大学見本市

  6. 2005年9月1日～2日、「みやぎの先端技術展示会」（ソニー(株)展示会

    2005/09/01 - 2005/09/02

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    2005年9月1日～2日、「みやぎの先端技術展示会」（ソニー(株)展示会）、ソニー株式会社本社10号館

  7. LASER EXPO 2005(レーザーエキスポ2005)

    2005/04/20 - 2005/04/22

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    LASER EXPO 2005(レーザーエキスポ2005)、パシフィコ横浜

  8. Sensor Expo Japan 2005(センサ総合展2005)

    2005/04/06 - 2005/04/08

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    Sensor Expo Japan 2005(センサ総合展2005)、東京ビックサイト

  9. 「患者さんの負担を減らす医療技術への挑戦」

    2009/01/01 -

  10. あしたの医療202X (7) 光で探し出す 危険病巣

    2008/11/18 -

  11. 高大連携地域開会公開講座東北大学特別授業

    2008/06/28 -

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    体の中から治療するミクロのロボット ～マイクロ・ナノテクノロジーを用いた低侵襲検査・治療機器の開発～

  12. 東北７県ビジネスマッチ2006

    2006/09/29 -

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    東北７県ビジネスマッチ2006 出展タイトル：東北大学先進医工学研究機構・芳賀研究室／メムザス株式会社

  13. 「もっと知りたい科学の最先端」 平成17年度 科学技術振興調整費成果発表会

    2006/03/25 -

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    「もっと知りたい科学の最先端」 平成17年度 科学技術振興調整費成果発表会、日本科学未来館 (主催：文部科学省)(出展タイトル：東北大学先進医工学研究機構 芳賀研究室)

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Media Coverage 40

  1. 「医新薬進」第6部 消化機能を救う(上) 体内トンネル 病変逃がさず 東北大とメムザス 内視鏡自在に、使い切りも

    日経産業新聞

    2008/06/17

    Type: Newspaper, magazine

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    日経産業新聞 2008年6月17日 「医新薬進」第6部 消化機能を救う(上) 体内トンネル 病変逃がさず 東北大とメムザス 内視鏡自在に、使い切りも

  2. 超極細の圧力センサー、ＭＥＭＳで直径半分に、東北大が開発、検査・治療機器に応用

    日経産業新聞

    2008/02/09

    Type: Newspaper, magazine

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    日経産業新聞 2008年2月9日 超極細の圧力センサー、ＭＥＭＳで直径半分に、東北大が開発、検査・治療機器に応用

  3. 医療分野に応用始まったMEMS技術

    ガスメディキーナ 2007, Vol. 12

    2007/10/31

    Type: Newspaper, magazine

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    ガスメディキーナ 2007, Vol. 12, pp. 38-40 医療分野に応用始まったMEMS技術 (2007年10月31日発行)

  4. 未来技術報告 第7回 マイクロ／ナノテクノロジーが切り拓く次世代の低侵襲治療デバイス

    AXIS, vol. 126

    2007/04/01

    Type: Newspaper, magazine

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    pp. 138-142 未来技術報告 第7回 マイクロ／ナノテクノロジーが切り拓く次世代の低侵襲治療デバイス (2007年4月1日発行

  5. 「医療・介護 改革の主役たち」 メムザス (仙台市) 切開せずに患部を手術

    日経産業新聞

    2007/02/16

    Type: Newspaper, magazine

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    「医療・介護 改革の主役たち」 メムザス (仙台市) 切開せずに患部を手術

  6. Vol. 8 第75夜 東北大学先進医工学研究機構 芳賀洋一

    単行本 絶望に効くクスリ(小学館、山田 玲司著)

    2006/10/05

    Type: Other

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    Vol. 8 第75夜 東北大学先進医工学研究機構 芳賀洋一 インタビュー漫画 「メディスンアトム」, pp. 112-122 取材後記 「ハカセのススメ]」 pp. 123-125 (2006年10月5日 発行)

  7. 2006産学官技術交流フェア 出展企業・紙上プレビュー 東北大学・芳賀洋一研究室

    日刊工業新聞

    2006/09/12

    Type: Newspaper, magazine

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    2006産学官技術交流フェア 出展企業・紙上プレビュー 東北大学・芳賀洋一研究室

  8. シリーズ東北大学100年物語 「医療革命の幕開け・・・医工学を探る」

    仙台放送

    2006/08/08

    Type: TV or radio program

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    シリーズ東北大学100年物語 「医療革命の幕開け・・・医工学を探る」

  9. 東北大 緊急時、壊死防ぐ腸閉塞の治療器具 先曲がり奥まで届く

    日経産業新聞

    2006/06/06

    Type: Newspaper, magazine

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    東北大 緊急時、壊死防ぐ腸閉塞の治療器具 先曲がり奥まで届く

  10. 理事長対談 医師にして工学博士 芳賀洋一先生と研究・社会・地域企業との協力について

    社団法人 仙台青年会議所 会報誌 のぞみ Vol. 379

    2006/06/01

    Type: Other

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    pp. 3-10 理事長対談 医師にして工学博士 芳賀洋一先生と研究・社会・地域企業との協力について

  11. 超音波で遺伝子治療 東北大 細胞刺激し投与 がん治療応用へ

    日経産業新聞

    2006/05/12

    Type: Newspaper, magazine

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    超音波で遺伝子治療 東北大 細胞刺激し投与 がん治療応用へ

  12. 超音波照射 体内に直接 抗がん剤治療を効率化 東北大・東京女子医大 医療器具を開発

    日経産業新聞

    2006/01/19

    Type: Newspaper, magazine

  13. 電子内視鏡、柔らかく 東北大、形状記憶合金使う

    日経産業新聞

    2006/01/10

    Type: Newspaper, magazine

  14. リサーチ最前線

    日経バイト(日経BP社) 2006年1月号

    2005/12/22

    Type: Newspaper, magazine

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    目指すは“ミクロ決死隊” 微小円筒表面への配線技術を開発

  15. 絶望に効くクスリ

    週刊ヤングサンデー 新年第1号

    2005/12/01

    Type: Newspaper, magazine

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    pp. 347-356 タイトル：第106夜 メディスンアトム

  16. 先端技術事業化

    インターネット 日経BP

    2005/11/14

    Type: Other

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    メムザスの能動屈曲イレウスチューブ、共同開発先が医療機器として申請中

  17. 「ミクロの決死圏」夢じゃない 医療器具製造など メムザス 体内治療に挑戦

    日経産業新聞

    2005/10/07

    Type: Newspaper, magazine

  18. メムザス、腸閉塞治療用能動屈曲カテーテルを開発

    インターネット 中小企業の為のビジネス瓦版

    2005/09/26

    Type: Newspaper, magazine

  19. 東北大発ベンチャー「メムザス」 腸閉塞カテーテル開発

    河北新報(県内版）

    2005/09/22

    Type: Newspaper, magazine

  20. 研究室だより

    電気学会論文誌E, Vol. 125E, No. 7 (2005年7月号)

    2005/07

    Type: Newspaper, magazine

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    東北大学先進医工学研究機構(TUBERO) ナノメディシン分野芳賀研究室

  21. (連載) 先端を見る

    朝日新聞(県内版)

    2005/06/09

    Type: Newspaper, magazine

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    ナノ単位の医療器具開発 東北大・芳賀洋一研究室

  22. レーザー治療用マイクロ2次元スキャナー

    O plus E 2005-6, Vol. 27, No. 6 株式会社 新技術コミュニケーションズ

    2005/06

    Type: Newspaper, magazine

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    pp. 607-608 O plus E NEWS (Laser Expo 2005展示紹介)

  23. レーザー治療しやすく 東北大 脳手術などに応用へ 新装置、光の向き調節自在

    日経産業新聞

    2005/04/20

    Type: Newspaper, magazine

  24. Challenger (挑戦者), MEMSデバイスを体内に入れメスを使わず“ピン・ポイント”治療 芳賀洋一氏 メムザス取締役

    日経マイクロデバイス (NIKKEI MICRODEVICES) 2005年3月号

    2005/03

    Type: Newspaper, magazine

  25. 誌面報告1 東北大学100周年記念セミナー 科学が次の100年で創り出せること

    日本経済新聞

    2005/02/28

    Type: Newspaper, magazine

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    第1回 「ナノが創る未来の世界 -機械工学の挑戦-」

  26. 芽はぐくむ研究室 東北大学・芳賀洋一助教授

    日刊工業新聞

    2005/01/07

    Type: Newspaper, magazine

  27. 東北大発VB設立 能動カテーテル3年後事業化目指す MEMS活用し医療機器

    日刊工業新聞

    2004/10/29

    Type: Newspaper, magazine

  28. 医療機器開発でVB 東北大教員らが来秋設立

    日経産業新聞

    2003/09/11

    Type: Newspaper, magazine

  29. 東北大教授ら 医療機器で大学発VB 来秋「医工学連携」に弾み

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  30. ピン使い触覚型表示装置 東北大など 素子に形状記憶合金

    日経産業新聞

    2003/06/23

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  31. 手術ロボットとマイクロマシンの可能性を探る

    Daily Bulletin 第２号 (第101回日本外科学会総会)

    2001/04/12

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    河北新報 (第２朝刊)

    2001/04/11

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  33. 超小型、でも多用途期待 「マイクロマシン」の研究盛ん 自動車部品軽量化、体内治療などに

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  34. NHKスペシャル 世紀を越えて あくなき挑戦 第2集 驚異の超微小マシン

    NHK

    2000/08/27

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  35. 視覚障害者のパソコン利用に朗報 点字ディスプレーを工学部生が開発

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    2000/07/11

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  36. パソコン情報 点字で表示 省エネタイプ新型機を試作 東北大グループ

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  37. 東北大工学部の１１人 米大学で研究成果披露へ

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  38. 「未来の創造者」題：新しい旅

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  1. 極細径光ファイバ圧力センサ

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    本研究の目的は体内狭所での圧力測定を可能にする外径125μmの極細径光ファイバ圧力センサを低侵襲医療ツールに組み込んだ、臨床で広く用いられるデバイスとして実用化することである。

  2. マイクロポンプシステムを用いた分子シャペロンとして働く薬物投与による遺伝性難聴の革新的治療法の創生

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  3. 光、音響エネルギー等利用マイクロ治療器の研究・調査

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    細血管を温存可能な内視鏡手術デバイス（レーザージェットメス）の開発

  6. 統合医療における生体情報の先進医工学的計測手法に関する調査研究

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  9. 細径かつ柔軟なシャフトをもつ電子内視鏡の研究

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  10. 内視鏡レーザー手術用２次元マイクロスキャナー

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  12. 集積化3軸MIセンサを用いた低侵襲検査治療ツール用3次元ナビゲーションシステムの開発

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  14. マイクロアクチュエータ、マイクロセンサの研究

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    微細加工技術を応用したマイクロアクチュエータ、およびマイクロセンサを、究開発し、それらの応用製品に関しても基礎研究を行う。

  15. 内視鏡的脳神経手術用超小型レーザースキャナーの開発

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