Details of the Researcher

PHOTO

Miki Hosaka
Section
Tohoku University Hospital
Job title
Specially Appointed Assistant Professor(Research)
Degree

Papers 40

  1. Self-measured home blood pressure highlights cardiovascular risk in women: the HOMED-BP study. International-journal

    Chiaki Ohata, Kei Asayama, Miki Hosaka, Kyoko Nomura, Tomoko Yamamura, Takahiro Kimura, Yukako Tatsumi, Masahiro Kikuya, Shigeru Shibata, Yutaka Imai, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension　46　(10)　2400-2408　2023/08/17

    DOI： 10.1038/s41440-023-01408-6 　

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    No studies examined sex differences in relation to the prognostic significance of self-measured home blood pressure (HBP). We compared the predictive power for the risk of cardiovascular events in 1547 women and 1516 men with hypertension using HBP captured at treatment-free baseline and during on-treatment follow-up, based on the Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED-BP) study. To express the change in risk for the composite cardiovascular endpoint associated with a 1-SD increase in HBP at baseline or on treatment, we derived multivariable-adjusted hazard ratios (HR) based on a Cox regression model. Over a median follow-up of 7.3 years, 100 composite events occurred, including 40 events in women. In women, systolic HBP both at baseline and on-treatment showed significant risk increment (at baseline: HR per 1-SD increment, 1.62; 95% confidence interval [CI], 1.17-2.24. on-treatment: HR, 1.74; 95% CI, 1.32-2.29). However, systolic HBP at baseline did not predict cardiovascular events in men (P = 0.25). On-treatment HBP was significantly associated with cardiovascular risk (P ≤ 0.012) irrespective of sex. Nevertheless, the point estimate of HR for systolic HBP in men (1.33) was less than that in women (1.74), and the interaction of sex with 1 SD-increase in systolic HBP in cardiovascular risk was significant irrespective of baseline (P = 0.039) or follow-up (P = 0.040) measurement when they were mutually adjusted. The increase in cardiovascular risk with the systolic HBP was steeper in women than in men for both baseline and on-treatment. The current findings unveil the importance of the control of systolic HBP, especially in women. Clinical Trial Registration: UMIN Clinical Trial Registry ( http://www.umin.ac.jp/ctr ), Unique identifier: C000000137.

  2. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究 Peer-reviewed

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　42回　223-223　2019/10

    Publisher: (NPO)日本高血圧学会

  3. Predictive power of home blood pressure indices at baseline and during follow-up in hypertensive patients: HOMED-BP study. International-journal Peer-reviewed

    Daisuke Watabe, Kei Asayama, Tomohiro Hanazawa, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    Hypertension research : official journal of the Japanese Society of Hypertension　41　(8)　622-628　2018/08

    DOI： 10.1038/s41440-018-0050-4 　

    ISSN： 0916-9636

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    We compared the predictive power for a major adverse cardiovascular event (MACE) of four home blood pressure (BP) indices (systolic BP, diastolic BP, mean BP, and pulse pressure (PP)) obtained at baseline before treatment and during the on-treatment follow-up period in 3147 patients with essential hypertension (women: 50.1%, mean age: 59.5 years). Associations between MACE and each index were determined using Cox proportional hazard models and the likelihood ratio (LR) test. During a median follow-up of 5.4 years, 46 patients experienced MACE, which was a composite of cardiovascular death, non-fatal stroke, and non-fatal myocardial infarction. The LR test showed that systolic, diastolic, and mean BP during follow-up was more closely associated with cardiovascular risk than the corresponding indices at baseline (LR χ2 for baseline versus follow-up: systolic BP, (6.0, P = 0.014) versus (11.3, P = 0.0008); diastolic BP, (0.4, P = 0.53) versus (12.4, P = 0.0004); mean BP, (3.2, P = 0.074) versus (15.0, P = 0.0001)), whereas neither PP at baseline nor that during follow-up was significantly associated with MACE risk. Among home BP indices during follow-up, mean BP further improved prediction models in which systolic or diastolic BP was already included (P ≤ 0.042), but neither systolic nor diastolic BP improved models with mean BP (P = 0.80). In addition to home systolic and diastolic BP, mean BP during follow-up period provides essential information in predicting future cardiovascular diseases, whereas its utilization should be further assessed by an intervention trial targeting mean BP levels.

  4. Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients Peer-reviewed

    Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai, on behalf of The J-HOME-ALB Study group

    Clinical and Experimental Hypertension　40　(5)　468-475　2018/07/04

    Publisher: Taylor and Francis Ltd

    DOI： 10.1080/10641963.2017.1403617 　

    ISSN： 1525-6006 1064-1963

  5. Home blood pressure predicts stroke incidence among older adults with impaired physical function: the Ohasama study. International-journal Peer-reviewed

    Keiko Murakami, Kei Asayama, Michihiro Satoh, Miki Hosaka, Ayako Matsuda, Ryusuke Inoue, Megumi Tsubota-Utsugi, Takahisa Murakami, Kyoko Nomura, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

    Journal of hypertension　35　(12)　2395-2401　2017/12

    DOI： 10.1097/HJH.0000000000001473 　

    ISSN： 0263-6352

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    OBJECTIVE: Several observational studies have found modifying effects of functional status on the association between conventional office blood pressure (BP) and adverse outcomes. We aimed to examine whether the association between higher BP and stroke was attenuated or inverted among older adults with impaired function using self-measured home BP measurements. METHODS: We followed 501 Japanese community-dwelling adults aged at least 60 years (mean age, 68.6 years) with no history of stroke. Multivariate-adjusted hazard ratios for 1-SD increase in home BP and office BP measurements were calculated by the Cox proportional hazards model. Functional status was assessed by self-reported physical function. RESULTS: During a median follow-up of 11.5 years, first strokes were observed in 47 participants. Higher home SBP, but not office SBP, was significantly associated with increased risk of stroke among both 349 participants with normal physical function and 152 participants with impaired physical function [hazard ratio (95% confidence interval) per 14.4-mmHg increase: 1.74 (1.12-2.69) and 1.77 (1.06-2.94), respectively], with no significant interaction for physical function (P = 0.56). Higher home DBP, but not office DBP, was also significantly associated with increased risk of stroke (P ≤ 0.029) irrespective of physical function (all P > 0.05 for interaction). Neither home BP nor office BP was significantly associated with all-cause mortality irrespective of physical function. CONCLUSION: Higher home BP was associated with increased risk of stroke even among those with impaired physical function. Measurements of home BP would be useful for stroke prevention, even after physical function decline.

  6. The fine-scale genetic structure and evolution of the Japanese population

    Fumihiko Takeuchi, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Minoru Isomura, Takayoshi Ohkubo, Yasuharu Tabara, Ken Yamamoto, Mitsuhiro Yokota, Xuanyao Liu, Xuanyao Liu, Woei Yuh Saw, Woei Yuh Saw, Dolikun Mamatyusupu, Wenjun Yang, Shuhua Xu, Shuhua Xu, Shuhua Xu, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Yik Ying Teo, Norihiro Kato, Koichi Akiyama, Hiroyuki Asano, Kei Asayama, Toshikazu Haga, Azusa Hara, Takuo Hirose, Miki Hosaka, Sahoko Ichihara, Yutaka Imai, Ryusuke Inoue, Aya Ishi-guro, Minoru Isomura, Masato Isono, Kei Kamide, Norihiro Kato, Tomohiro Katsuya, Masahiro Kikuya, Katsuhiko Kohara, Tatsuaki Matsubara, Ayako Matsuda, Hirohito Metoki, Tetsuro Miki, Tetsuro Miki, Keiko Murakami, Toru Nabika, Masahiro Nakatochi, Toshio Ogihara, Keizo Ohnaka, Takayoshi Ohkubo, Hiromi Rakugi, Michihiro Satoh, Kuni hiro Shiwaku, Ken Sugimoto, Yasuharu Tabara, Yoichi Takami, Ryoichi Takayanagi, Fumihiko Takeuchi, Megumi Tsubota-Utsugi, Ken Yamamoto, Koichi Yamamoto, Masayuki Yamasaki, Daisaku Yasui, Mitsuhiro Yokota

    PLoS ONE　12　2017/11/01

    DOI： 10.1371/journal.pone.0185487 　

  7. Seasonal variation in self-measured home blood pressure among patients on antihypertensive medications: HOMED-BP study Peer-reviewed

    Tomohiro Hanazawa, Kei Asayama, Daisuke Watabe, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION RESEARCH　40　(3)　284-290　2017/03

    DOI： 10.1038/hr.2016.133 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  8. Lacunar Infarcts Rather than White Matter Hyperintensity as a Predictor of Future Higher Level Functional Decline: The Ohasama Study Peer-reviewed

    Megumi Tsubota-Utsugi, Michihiro Satoh, Naoki Tomita, Azusa Hara, Takeo Kondo, Miki Hosaka, Sho Saito, Kei Asayama, Ryusuke Inoue, Mikio Hirano, Aya Hosokawa, Keiko Murakami, Takahisa Murakami, Hirohito Metoki, Masahiro Kikuya, Shin-Ichi Izumi, Yutaka Imai, Takayoshi Ohkubo

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES　26　(2)　376-384　2017/02

    DOI： 10.1016/j.jstrokecerebrovasdis.2016.09.036 　

    ISSN： 1052-3057

    eISSN： 1532-8511

  9. Risk Factors for Stroke among Young-Old and Old-Old Community-Dwelling Adults in Japan: The Ohasama Study Peer-reviewed

    Keiko Murakami, Kei Asayama, Michihiro Satoh, Ryusuke Inoue, Megumi Tsubota-Utsugi, Miki Hosaka, Ayako Matsuda, Kyoko Nomura, Takahisa Murakami, Masahiro Kikuya, Hirohito Metoki, Yutaka Imai, Takayoshi Ohkubo

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　24　(3)　290-300　2017

    DOI： 10.5551/jat.35766 　

    ISSN： 1340-3478

    eISSN： 1880-3873

  10. Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study Peer-reviewed

    Michihiro Satoh, Ryusuke Inoue, Hideko Tada, Miki Hosaka, Hirohito Metoki, Kei Asayama, Takahisa Murakami, Nariyasu Mano, Takayoshi Ohkubo, Katsuyo Yagihashi, Kazuhiko Hoshi, Masakuni Suzuki, Yutaka Imai

    JOURNAL OF HYPERTENSION　34　(8)　1578-1585　2016/08

    DOI： 10.1097/HJH.0000000000000976 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  11. The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements Peer-reviewed

    Michihiro Satoh, Toshikazu Haga, Miki Hosaka, Taku Obara, Hirohito Metoki, Takahisa Murakami, Masahiro Kikuya, Ryusuke Inoue, Kei Asayama, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

    JOURNAL OF HYPERTENSION　34　(6)　1218-1223　2016/06

    DOI： 10.1097/HJH.0000000000000902 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  12. Does Antihypertensive Drug Class Affect Day-to-Day Variability of Self-Measured Home Blood Pressure? The HOMED-BP Study Peer-reviewed

    Kei Asayama, Takayoshi Ohkubo, Tomohiro Hanazawa, Daisuke Watabe, Miki Hosaka, Michihiro Satoh, Daisaku Yasui, Jan A. Staessen, Yutaka Imai

    JOURNAL OF THE AMERICAN HEART ASSOCIATION　5　(3)　e002995　2016/03

    DOI： 10.1161/JAHA.115.002995 　

    ISSN： 2047-9980

  13. Home blood pressure level and decline in renal function among treated hypertensive patients: the J-HOME-Morning Study Peer-reviewed

    Kazuki Ishikura, Taku Obara, Masahiro Kikuya, Michihiro Satoh, Miki Hosaka, Hirohito Metoki, Hidekazu Nishigori, Nariyasu Mano, Masaaki Nakayama, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION RESEARCH　39　(2)　107-112　2016/02

    DOI： 10.1038/hr.2015.110 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  14. Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements The Ohasama Study Peer-reviewed

    Michihiro Satoh, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Miki Hosaka, Megumi Tsubota-Utsugi, Taku Obara, Aya Ishiguro, Keiko Murakami, Ayako Matsuda, Daisaku Yasui, Takahisa Murakami, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION　67　(1)　48-55　2016/01

    DOI： 10.1161/HYPERTENSIONAHA.115.06461 　

    ISSN： 0194-911X

    eISSN： 1524-4563

  15. Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study Peer-reviewed

    Keiko Murakami, Hirohito Metoki, Michihiro Satoh, Kei Asayama, Miki Hosaka, Ayako Matsuda, Ryusuke Inoue, Megumi Tsubota-Utsugi, Takahisa Murakami, Kyoko Nomura, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    NEUROEPIDEMIOLOGY　47　(2)　109-116　2016

    DOI： 10.1159/000452220 　

    ISSN： 0251-5350

    eISSN： 1423-0208

  16. Mapping the genetic diversity of HLA haplotypes in the Japanese populations Peer-reviewed

    Woei-Yuh Saw, Japanese Genome Variation Consortium, Xuanyao Liu, Chiea-Chuen Khor, Fumihiko Takeuchi, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Takayoshi Ohkubo, Yasuharu Tabara, Ken Yamamoto, Mitsuhiro Yokota, Koichi Akiyama, Hiroyuki Asano, Kei Asayama, Toshikazu Haga, Azusa Hara, Takuo Hirose, Miki Hosaka, Sahoko Ichihara, Yutaka Imai, Ryusuke Inoue, Aya Ishiguro, Minoru Isomura, Masato Isono, Kei Kamide, Norihiro Kato, Masahiro Kikuya, Katsuhiko Kohara, Tatsuaki Matsubara, Ayako Matsuda, Hirohito Metoki, Tetsuro Miki, Keiko Murakami, Masahiro Nakatochi, Toshio Ogihara, Keizo Ohnaka, Hiromi Rakugi, Michihiro Satoh, Kunihiro Shiwaku, Ken Sugimoto, Yoichi Takami, Ryoichi Takayanagi, Megumi Tsubota-Utsugi, Koichi Yamamoto, Masayuki Yamasaki, Daisaku Yasui, Yik-Ying Teo

    Scientific Reports　5　17855　2015/12/09

    Publisher: Nature Publishing Group

    DOI： 10.1038/srep17855 　

    ISSN： 2045-2322

  17. Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development Peer-reviewed

    Miki Hosaka, Kei Asayama, Jan A. Staessen, Nozomi Tatsuta, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Hiroshi Satoh, Yutaka Imai, Kunihiko Nakai

    HYPERTENSION RESEARCH　38　(11)　776-782　2015/11

    DOI： 10.1038/hr.2015.63 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  18. Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide Peer-reviewed

    Miki Hosaka, Hirohito Metoki, Michihiro Satoh, Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Taku Obara, Takuo Hirose, Yutaka Imai

    HYPERTENSION RESEARCH　38　(10)　701-707　2015/10

    DOI： 10.1038/hr.2015.64 　

    ISSN： 0916-9636

    eISSN： 1348-4214

  19. Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study Peer-reviewed

    Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Koichi Node, Yutaka Imai, Takayoshi Ohkubo

    JOURNAL OF HYPERTENSION　33　(8)　1536-1541　2015/08

    DOI： 10.1097/HJH.0000000000000570 　

    ISSN： 0263-6352

    eISSN： 1473-5598

  20. Salt intake and the validity of a salt intake assessment system based on a 24-h dietary recall method in pregnant Japanese women Peer-reviewed

    Michihiro Satoh, Yumi Tanno, Miki Hosaka, Hirohito Metoki, Taku Obara, Kei Asayama, Kazuhiko Hoshi, Masakuni Suzuki, Nariyasu Mano, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　37　(6)　459-462　2015/08

    DOI： 10.3109/10641963.2015.1057832 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  21. Living situations associated with poor dietary intake among healthy japanese elderly: The ohasama study Peer-reviewed

    Megumi Tsubota-Utsugi, M. Kikuya, M. Satoh, R. Inoue, M. Hosaka, H. Metoki, T. Hirose, K. Asayama, Y. Imai, T. Ohkubo

    Journal of Nutrition, Health and Aging　19　(4)　375-382　2015/04/01

    Publisher: Springer-Verlag France

    DOI： 10.1007/s12603-015-0456-5 　

    ISSN： 1760-4788 1279-7707

  22. Association of Aldosterone-to-Renin Ratio With Hypertension Differs by Sodium Intake: The Ohasama Study Peer-reviewed

    Michihiro Satoh, Masahiro Kikuya, Miki Hosaka, Kei Asayama, Ryusuke Inoue, Hirohito Metoki, Megumi Tsubota-Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    AMERICAN JOURNAL OF HYPERTENSION　28　(2)　208-215　2015/02

    DOI： 10.1093/ajh/hpu115 　

    ISSN： 0895-7061

    eISSN： 1941-7225

  23. Differential effects of angiotensin II receptor blocker and losartan/hydrochlorothiazide combination on central blood pressure and augmentation index Peer-reviewed

    Hirohito Metoki, Taku Obara, Kei Asayama, Michihiro Satoh, Miki Hosaka, Noha Elnagar, Yoshinori Miyawaki, Iwao Kojima, Takayoshi Ohkubo, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　37　(4)　294-302　2015

    DOI： 10.3109/10641963.2014.960972 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  24. A Survey of Self-medication Practices and Related Factors in the General Population: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Akihiro Matsumoto, Azusa Hara, Saki Iwamori, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Miki Hosaka, Kei Asayama, Nobuyuki Takahashi, Hiroshi Sato, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　134　(12)　1347-1355　2014/12

    ISSN： 0031-6903

  25. Personality Traits as Predictors of Decline in Higher-Level Functional Capacity over a 7-Year Follow-Up in Older Adults: The Ohasama Study Peer-reviewed

    Megumi Tsubota-Utsugi, Michihiro Satoh, Miki Hosaka, Ryusuke Inoue, Kei Asayama, Takuo Hirose, Hirohito Metoki, Masahiro Kikuya, Yutaka Imai, Takayoshi Ohkubo

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　234　(3)　197-207　2014/11

    DOI： 10.1620/tjem.234.197 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  26. [Circadian blood pressure variation under several pathophysiological conditions including secondary hypertension]. Peer-reviewed

    Imai Y, Hosaka M, Satoh M

    Nihon rinsho. Japanese journal of clinical medicine　72　(8)　1429-1434　2014/08

    ISSN： 0047-1852

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    Abnormality of circadian blood pressure (BP) variation, i.e. non-dipper, riser, nocturnal hypertension etc, is brought by several pathophysiological conditions especially by secondary hypertension. These pathophysiological conditions are classified into several categories, i.e. disturbance of autonomic nervous system, metabolic disorder, endocrine disorder, disorder of Na and water excretion (e.g. sodium sensitivity), severe target organ damage and ischemia, cardiovascular complications and drug induced hypertension. Each pathophysiological condition which brings disturbance of circadian BP variation is included in several categories, e.g. diabetes mellitus is included in metabolic disorder, autonomic imbalance, sodium sensitivity and endocrine disorder. However, it seems that unified principle of the genesis of disturbance of circadian BP variation in many pathophysiological conditions is autonomic imbalance. Thus, it is concluded that disturbance of circadian BP variation is not purposive biological behavior but the result of autonomic imbalance which looks as if compensatory reaction such as exaggerated Na-water excretion during night in patient with Na-water retention who reveals disturbed circadian BP variation.

  27. Animal Protein Intake Is Associated with Higher-Level Functional Capacity in Elderly Adults: The Ohasama Study Peer-reviewed

    Eri Imai, Megumi Tsubota-Utsugi, Masahiro Kikuya, Michihiro Satoh, Ryuske Inoue, Miki Hosaka, Hirohito Metoki, Naomi Fukushima, Ayumi Kurimoto, Takuo Hirose, Kei Asayama, Yutaka Imai, Takayoshi Ohkubo

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　62　(3)　426-434　2014/03

    DOI： 10.1111/jgs.12690 　

    ISSN： 0002-8614

    eISSN： 1532-5415

  28. Clinical significance of home blood pressure measurements for the prevention and management of high blood pressure Peer-reviewed

    Yutaka Imai, Miki Hosaka, Noha Elnagar, Michihiro Satoh

    Clinical and Experimental Pharmacology and Physiology　41　(1)　37-45　2014/01

    DOI： 10.1111/1440-1681.12142 　

    ISSN： 0305-1870 1440-1681

  29. Validity of salt intake assessment system based on a 24-h dietary recall method using a touch panel computer Peer-reviewed

    Michihiro Satoh, Noriko Kato, Miki Hosaka, Noha Elnagar, Takuya Tsuchihashi, Naoto Yagi, Futoshi Ebara, Kiyoshi Uchiba, Hisao Mori, Mitsutoshi Kato, Hareaki Yamamoto, Katsumi Yoshida, Masaaki Miyakawa, Yutaka Hatori, Yoshiharu Yamamoto, Tomohiro Katsuya, Yoshihiko Watanabe, Shigeo Yatagai, Hiroshi Sato, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(7)　471-477　2014

    DOI： 10.3109/10641963.2013.863319 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  30. The velocity of home blood pressure reduction in response to low-dose eplerenone combined with other antihypertensive drugs determined by exponential decay function analysis Peer-reviewed

    Noha Elnagar, Michihiro Satoh, Miki Hosaka, Kei Asayama, Kazuki Ishikura, Taku Obara, Nariyasu Mano, Takayoshi Ohkubo, Yutaka Imai

    CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　83-91　2014

    DOI： 10.3109/10641963.2014.892117 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  31. Aldosterone-to-renin ratio and nocturnal blood pressure decline assessed by self-measurement of blood pressure at home: the Ohasama Study Peer-reviewed

    Michihiro Satoh, Miki Hosaka, Kei Asayama, Masahiro Kikuya, Ryusuke Inoue, Hirohito Metoki, Megumi T. Utsugi, Azusa Hara, Takuo Hirose, Taku Obara, Takefumi Mori, Kazuhito Totsune, Haruhisa Hoshi, Nariyasu Mano, Yutaka Imai, Takayoshi Ohkubo

    CLINICAL AND EXPERIMENTAL HYPERTENSION　36　(2)　108-114　2014

    DOI： 10.3109/10641963.2014.892121 　

    ISSN： 1064-1963

    eISSN： 1525-6006

  32. Night-time blood pressure is associated with the development of chronic kidney disease in a general population: The Ohasama Study Peer-reviewed

    Atsuhiro Kanno, Masahiro Kikuya, Kei Asayama, Michihiro Satoh, Ryusuke Inoue, Miki Hosaka, Hirohito Metoki, Taku Obara, Haruhisa Hoshi, Kazuhito Totsune, Toshinobu Sato, Yoshio Taguma, Hiroshi Sato, Yutaka Imai, Takayoshi Ohkubo

    Journal of Hypertension　31　(12)　2410-2417　2013/12

    DOI： 10.1097/HJH.0b013e328364dd0f 　

    ISSN： 0263-6352 1473-5598

  33. Predictive power of home blood pressure and clinic blood pressure in hypertensive patients with impaired glucose metabolism and diabetes. International-journal Peer-reviewed

    Yuichi Noguchi, Kei Asayama, Jan A Staessen, Munemichi Inaba, Takayoshi Ohkubo, Miki Hosaka, Michihiro Satoh, Kei Kamide, Takuya Awata, Shigehiro Katayama, Yutaka Imai

    Journal of hypertension　31　(8)　1593-602　2013/08

    DOI： 10.1097/HJH.0b013e328361732c 　

    ISSN： 0263-6352

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    OBJECTIVES: We evaluated the predictive power of home blood pressure and clinic blood pressure based on the long-term cardiovascular outcome in hypertensive patients with and without impaired glucose metabolism (IGM). METHOD: The multicentre Hypertension Objective Treatment Based on Measurement by Electrical Devices Blood Pressure trial (HOMED-BP) involved 3080 patients (50.5% women; mean age 59.7 years) with a baseline, untreated home/clinic blood pressure as well as follow-up, on-treatment blood pressure. Of those, 979 had IGM and 475 of these patients had diabetes. We applied Cox regression pooling all participants in a cohort analysis in which IGM and normal glucose metabolism (NGM) were separated. RESULTS: During median 5.45 years follow-up, cardiovascular events occurred in 48 patients with IGM and 53 patients with NGM. Baseline home SBP significantly predicted cardiovascular outcome among IGM group [hazard ratio 1.68, 95% CI 1.26-2.26, P = 0.0005]. On-treatment home blood pressure was a significant predictor for cardiovascular risk even after the further adjustment of baseline blood pressure level (P ≤ 0.027), whereas on-treatment clinic blood pressure was not in NGM group (P ≥ 0.37). The event rate in IGM was approximately two times higher than that in NGM (9.95 vs. 4.88 per 1000 patient-years), resulted to the low 5-year number needed to treat in IGM patients [83 vs. 121 for 1-SD (13.1 mmHg) home SBP reduction, and 62 vs. 104 for 1-SD (9.5 mmHg) home DBP reduction). CONCLUSION: The present findings suggest that long-term cardiovascular risk in IGM patients should be assessed based on home blood pressure, not on clinic blood pressure.

  34. Children's Home Blood Pressure and Growth Environment Peer-reviewed

    Miki Hosaka, Kei Asayama, Takayoshi Ohkubo, Kunihiko Nakai, Yutaka Imai

    HYPERTENSION　61　(4)　E33-E33　2013/04

    DOI： 10.1161/HYPERTENSIONAHA.111.00843 　

    ISSN： 0194-911X

  35. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development (vol 36, pg 117, 2012) Peer-reviewed

    Miki Hosaka, Kei Asayama, Jan A. Staessen, Takayoshi Ohkubo, Katsuhisa Hayashi, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    HYPERTENSION RESEARCH　36　(2)　184-184　2013/02

    DOI： 10.1038/hr.2012.203 　

    ISSN： 0916-9636

  36. Breastfeeding leads to lower blood pressure in 7-year-old Japanese children: Tohoku Study of Child Development Peer-reviewed

    Miki Hosaka, Kei Asayama, Jan A Staessen, Takayoshi Ohkubo, Katsuhisa Hayashi, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    Hypertension Research　36　(2)　117-122　2013/02

    DOI： 10.1038/hr.2012.128 　

    ISSN： 0916-9636 1348-4214

  37. Relationship Between Stroke Subtypes and Morning Surge or Dipping Pattern Peer-reviewed

    Miki Hosaka, Kei Asayama, Yutaka Imai, Takayoshi Ohkubo

    HYPERTENSION　61　(2)　E21-E21　2013/02

    DOI： 10.1161/HYPERTENSIONAHA.111.00247 　

    ISSN： 0194-911X

  38. Home Blood Pressure Variability as Cardiovascular Risk Factor in the Population of Ohasama Peer-reviewed

    Kei Asayama, Masahiro Kikuya, Rudolph Schutte, Lutgarde Thijs, Miki Hosaka, Michihiro Satoh, Azusa Hara, Taku Obara, Ryusuke Inoue, Hirohito Metoki, Takuo Hirose, Takayoshi Ohkubo, Jan A. Staessen, Yutaka Imai

    HYPERTENSION　61　(1)　61-+　2013/01

    DOI： 10.1161/HYPERTENSIONAHA.111.00138 　

    ISSN： 0194-911X

  39. Mother-offspring aggregation in home versus conventional blood pressure in the Tohoku Study of Child Development (TSCD) Peer-reviewed

    Kei Asayama, Jan A. Staessen, Katsuhisa Hayashi, Miki Hosaka, Nozomi Tatsuta, Naoyuki Kurokawa, Michihiro Satoh, Takanao Hashimoto, Takuo Hirose, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Masahiro Kikuya, Takayoshi Ohkubo, Kunihiko Nakai, Yutaka Imai, Hiroshi Satoh

    ACTA CARDIOLOGICA　67　(4)　449-456　2012/08

    DOI： 10.2143/AC.67.4.2170687 　

    ISSN： 0001-5385

  40. Relationship of dysregulation of glucose metabolism with white-coat hypertension: the Ohasama study Peer-reviewed

    Miki Hosaka, Akira Mimura, Kei Asayama, Takayoshi Ohkubo, Katsuhisa Hayashi, Masahiro Kikuya, Michihiro Sato, Takanao Hashimoto, Atsuhiro Kanno, Azusa Hara, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Haruhisa Hoshi, Hiroshi Satoh, Yoshitomo Oka, Yutaka Imai

    HYPERTENSION RESEARCH　33　(9)　937-943　2010/09

    DOI： 10.1038/hr.2010.114 　

    ISSN： 0916-9636

Show all ︎Show first 5

Misc. 30

  1. 本態性高血圧患者における治療前および降圧治療中の家庭血圧指標の予後予測能 HOMED-BP研究

    渡部 大介, 浅山 敬, 花澤 智大, 保坂 実樹, 佐藤 倫広, 安井 大策, 小原 拓, 井上 隆輔, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　42回　223-223　2019/10

    Publisher: (NPO)日本高血圧学会

  2. 本態性高血圧患者における未治療時および降圧治療中の家庭血圧指標(収縮期、拡張期、平均、脈圧)の脳心血管イベント予測能 HOMED-BP研究

    渡部 大介, 浅山 敬, 花澤 智大, 安井 大策, 井上 隆輔, 保坂 実樹, 佐藤 倫広, 小原 拓, 目時 弘仁, 菊谷 昌浩, 今井 潤, 大久保 孝義

    日本高血圧学会総会プログラム・抄録集　38回　396-396　2015/10

    Publisher: (NPO)日本高血圧学会

  3. 家庭血圧に基づくアジルサルタンの臨床的評価

    芳賀 俊和, 佐藤 倫広, 保坂 実樹, 渡部 大介, 小原 拓, 目時 弘仁, 浅山 敬, 菊谷 昌浩, 眞野 成康, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　397-397　2015/10

    Publisher: (NPO)日本高血圧学会

  4. 新生児血圧に影響する要因の検討 BOSHI-新生児研究

    井上 隆輔, 目時 弘仁, 大久保 孝義, 小原 拓, 菊谷 昌浩, 佐藤 倫広, 保坂 実樹, 多田 秀子, 八木橋 香津代, 田中 耕平, 星 和彦, 森 滋, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　406-406　2015/10

    Publisher: (NPO)日本高血圧学会

  5. 出生後18ヵ月の体重増加と7歳児の家庭血圧の関連 Tohoku Study of Child Development

    保坂 実樹, 浅山 敬, 佐藤 倫広, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　38回　451-451　2015/10

    Publisher: (NPO)日本高血圧学会

  6. 電子血圧計を用いた客観的な高血圧治療に関する研究(HOMED‐BP研究)参加主治医に関する質問票調査

    YASUI DAISAKU, ASAYAMA KEI, SATO MICHIHIRO, HOSAKA MIKI, HANAZAWA TOMOHIRO, WATANABE DAISUKE, OKUBO TAKAYOSHI, IMAI JUN

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　4th　125-125　2015/05/23

    Publisher: (NPO)日本高血圧学会

  7. 一般地域住民におけるセルフメディケーションの実態とその要因に関する調査 大迫研究

    佐藤 倫広, 松本 章裕, 原 梓, 岩森 紗希, 小原 拓, 菊谷 昌浩, 目時 弘仁, 保坂 実樹, 淺山 敬, 高橋 信行, 佐藤 博, 眞野 成康, 今井 潤, 大久保 孝義

    薬学雑誌　134　(12)　1347-1355　2014/12

    Publisher: (公社)日本薬学会

    ISSN： 0031-6903

    eISSN： 1347-5231

    More details Close

    一般地域住民におけるセルフメディケーションの実態とその要因について検討した。大迫町の一般地域住民1008例を対象とした。OTC・サプリメントの使用経験があったものは519例(51.5%)であった。使用したことのあるOTCとして、風邪薬、目薬、湿布が、サプリメントの健康食品や栄養ドリンクが高率に挙げられた。OTC・サプリメント使用経験がある者で、女性及び脂質異常症既往者が高率で、現在喫煙者が低率であった。家庭血圧は、OTC・サプリメント使用経験がある者で低値であった。OTC・サプリメント使用経験の規定因子として、女性、配置販売業者の訪問回数(年に2〜3回以上)、脂質異常症あり.及び家庭収縮期血圧低値が選択された。降圧薬服用量において、家庭血圧とOTC・サプリメント使用経験との間に負の関連を認めた。

  8. 降圧治療中患者における家庭血圧の季節変動:HOMED‐BP研究

    HANAZAWA TOMOHIRO, ASAYAMA KEI, SATO MICHIHIRO, HOSAKA MIKI, YASUI DAISAKU, OKUBO TAKAYOSHI, IMAI JUN

    臨床薬理　45　(Supplement)　S254-S254　2014/11/07

    Publisher: (一社)日本臨床薬理学会

    ISSN： 0388-1601

    eISSN： 1882-8272

  9. 注目される用語の解説 仮面高血圧

    今井 潤, 保坂 実樹, 佐藤 倫広

    動脈硬化予防　13　(3)　85-86　2014/10

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  10. 妊婦における尿中塩分排泄量と塩分・栄養診断システム算出の塩分摂取量の相関

    佐藤 倫広, 丹野 由美, 保坂 実樹, 目時 弘仁, 小原 拓, 淺山 敬, 眞野 成康, 星 和彦, 鈴木 雅洲, 今井 潤

    日本高血圧学会総会プログラム・抄録集　37回　370-370　2014/10

    Publisher: (NPO)日本高血圧学会

  11. 本態性高血圧患者における家庭血圧と脳心血管疾患発症リスクの男女別解析 HOMED-BP研究

    保坂 実樹, 浅山 敬, 佐藤 倫広, 井上 隆輔, 小原 拓, 目時 弘仁, 菊谷 昌浩, 大久保 孝義, 今井 潤

    日本高血圧学会総会プログラム・抄録集　37回　376-376　2014/10

    Publisher: (NPO)日本高血圧学会

  12. 【高血圧薬物療法を見直す-降圧薬の単剤、併用、配合剤-】 高血圧の時間治療

    今井 潤, 保坂 実樹, 佐藤 倫広

    Circulation　4　(5)　83-94　2014/09

    Publisher: (株)医学出版

  13. DIFFERENCE IN LIVING FORMS ASSOCIATED WITH POOR DIETARY INTAKE AMONG JAPANESE ELDERLY: THE OHASAMA STUDY

    M. Tsubota-Utsugi, M. Kikuya, M. Satoh, R. Inoue, M. Hosaka, H. Metoki, N. Fukushima, T. Hirose, K. Asayama, Y. Imai, T. Ohkubo

    INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE　21　S68-S69　2014/08

    ISSN： 1070-5503

    eISSN： 1532-7558

  14. 【血圧サーカディアンリズム-24時間血圧管理の重要性-】 血圧サーカディアンリズムが障害される病態とその機序 二次性高血圧

    今井 潤, 保坂 実樹, 佐藤 倫広

    日本臨床　72　(8)　1429-1434　2014/08

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  15. 【血圧変動へのRASの関与を探る】 血圧変動に対するRAS抑制薬の効果 臨床研究より

    今井 潤, 保坂 実樹, 佐藤 倫広

    Angiotensin Research　11　(3)　154-160　2014/07

    Publisher: (株)先端医学社

    ISSN： 1348-8740

  16. 家庭血圧に基づく血漿アルドステロン濃度/血漿レニン活性化とNon‐dippingの関連―大迫研究―

    SATO TOMOHIRO, HOSAKA MIKI, KIKUYA MASAHIRO, ASAYAMA KEI, INOUE RYUSUKE, TSUBOTA MEGUMI, HARA AZUSA, HIROSE TAKUO, OHARA TAKU, METOKI HIROHITO, TOTSUNE KAZUHITO, HOSHI HARUHISA, MANO NARIYASU, IMAI JUN, OKUBO TAKAYOSHI

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　3rd　115-115　2014/05/24

    Publisher: (NPO)日本高血圧学会

  17. 【JSH2014を読み解く-GL改訂の機会に、あなたの高血圧診療を見直しませんか?-】 高血圧診療アップデート 血圧測定・血圧変動

    今井 潤, 保坂 実樹, 佐藤 倫広

    治療　96　(5)　808-812　2014/05

    Publisher: (株)南山堂

    ISSN： 0022-5207

  18. 危険因子 家庭血圧

    保坂実樹, 大久保孝義

    動脈硬化予防　12　(4)　76-77　2014/02/10

    Publisher: (株)メジカルビュー社

    ISSN： 1347-7056

  19. Clinical significance of home blood pressure measurements for the prevention and management of high blood pressure

    Yutaka Imai, Miki Hosaka, Noha Elnagar, Michihiro Satoh

    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　41　(1)　37-45　2014/01

    DOI： 10.1111/1440-1681.12142 　

    ISSN： 1440-1681

  20. Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis

    Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, T. Mountokalakis, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

    PLoS Medicine　11　(1)　2014/01/01

    Publisher: Public Library of Science

    DOI： 10.1371/journal.pmed.1001591 　

    ISSN： 1549-1676 1549-1277

  21. 妊娠高血圧症候群既往と出産7年後の母児の家庭血圧との関連:Tohoku Study of Child Development

    保坂実樹, 浅山敬, 佐藤倫広, 菊谷昌浩, 大久保孝義, 今井潤, 佐藤洋

    日本高血圧学会総会プログラム・抄録集　36th　319-319　2013/10/24

    Publisher: (NPO)日本高血圧学会

  22. 治療中高血圧患者の高血圧管理における保険調剤薬局の関与:J‐HOME‐Morning研究

    小原拓, 小林由香, 池田うらら, 保坂実樹, 佐藤倫広, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

    日本医療薬学会年会講演要旨集　23rd　405-405　2013/08/28

    Publisher: 日本医療薬学会

  23. The velocity of antihypertensive effect of candesartan/hydrochlorothiazide combination and incremental dose of candesartan evaluated by daily serial morning home blood pressure measurements

    M. Hosaka, K. Asayama, H. Metoki, M. Satoh, T. Obara, M. Kikuya, T. Ohkubo, Y. Imai

    EUROPEAN HEART JOURNAL　34　1118-1119　2013/08

    ISSN： 0195-668X

    eISSN： 1522-9645

  24. 夜間血圧降下度とモーニングサージ. Peer-reviewed

    保坂 実樹, 浅山 敬, 大久保 孝義

    血圧　20　4-5　2013

  25. 妊婦に対する気管支喘息治療薬の処方状況の把握に関する研究

    保坂実樹, 小原拓, 目時弘仁, 佐藤倫広, 大久保孝義, 八重樫伸生, 眞野成康, 栗山進一

    日本医療薬学会年会講演要旨集　23　(0)　435-435　2013

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.23.0_435_2 　

  26. カンデサルタン8mg/HCTZ6.25mg配合剤とカンデサルタン12mgの家庭血圧/外来血圧に及ぼす作用に関する多施設共同無作為比較試験(J‐HOME‐CARD研究):主結果報告

    今井潤, 保坂実樹, 目時弘仁, 佐藤倫広, 小原拓, 菊谷昌浩, 大久保孝義

    日本高血圧学会総会プログラム・抄録集　35th　468-468　2012/09/20

    Publisher: (NPO)日本高血圧学会

  27. 母の家庭血圧が7歳児の家庭血圧値および家庭心拍数に与える影響について

    保坂 実樹, 浅山 敬, 龍田 希, 佐藤 倫広, 橋本 貴尚, 小原 拓, 目時 弘仁, 黒川 修行, 菊谷 昌浩, 大久保 孝義, 仲井 邦彦, Staessen Jan A, 今井 潤, 佐藤 洋

    日本高血圧学会総会プログラム・抄録集　34回　585-585　2011/10

    Publisher: (NPO)日本高血圧学会

  28. 母乳栄養と7歳児の家庭血圧の関連 東北スタディ

    保坂 実樹, 浅山 敬, 佐藤 倫広, 橋本 貴尚, 目時 弘仁, 菊谷 昌浩, 大久保 孝義, 今井 潤, 佐藤 洋

    日本高血圧学会総会プログラム・抄録集　33回　286-286　2010/10

    Publisher: (NPO)日本高血圧学会

  29. 胎児期のメチル水銀曝露と7歳小児の家庭血圧との関連 東北スタディから

    浅山 敬, 保坂 実樹, 龍田 希, 目時 弘仁, 鈴木 恵太, 黒川 修行, 大久保 孝義, 仲井 邦彦, 今井 潤, 佐藤 洋

    日本衛生学雑誌　65　(2)　283-283　2010/04

    Publisher: (一社)日本衛生学会

    ISSN： 0021-5082

  30. 小児期における家庭血圧と出生体重との関連 出生コホート調査

    林 克剛, 浅山 敬, 大久保 孝義, 保坂 実樹, 今井 潤, 佐藤 洋

    日本高血圧学会総会プログラム・抄録集　32回　210-210　2009/10

    Publisher: (NPO)日本高血圧学会

Show all ︎Show first 5

Research Projects 3

  1. Research to promote the development of innovative medical devices based on the optimization of clinical evaluation methods by subjective evaluation

    HOSAKA MIKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

    More details Close

    In medical device development, subjective evaluation is a typical evaluation method that differs from drug development. Subjective evaluation had been employed in about 10-20% of the medical devices approved in the last few years. In the case of medical devices for which subjective evaluation items were adopted in the clinical trials, it is considered that the optimal evaluation method for issues to be evaluated was subjective evaluation. In the future development of medical devices, it is necessary to understand the characteristics of the medical devices, consider whether there are established objective evaluation indicators or whether subjective evaluation by non-patients is possible, and select the most appropriate evaluation indicators.

  2. 胎生期から成人にわたる医療薬学的視点からの生活習慣病予防に対するアプローチ

    保坂 実樹

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2013/04/01 - 2016/03/31

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    本研究は家庭血圧をツールとして、成人において、降圧薬がもたらす代謝系への影響および妊婦・授乳婦の薬剤使用が小児の家庭血圧および成長に及ぼす影響を検討することを目的としている。 今年度は、J-HOME研究の対象者を用いて、尿中アルブミンクレアチニン比(UACR)が10mg/g Cr以上300mg/g Cr未満である本態性高血圧患者に対するイルベサルタン単独治療およびアムロジピン、エホニジピン、トリクロルメチアジドとの併用療法が腎機能、家庭血圧に及ぼす影響を検討した。対象者175名中、11名はイルベサルタン100/200 mgで家庭収縮期血圧が125 mmHg未満に降圧した。イルベサルタン単剤で家庭血圧が降圧目標に達しなかった対象者のうち、115名が、イルベサルタンと、アムロジピン、エホニジピン、もしくはトリクロルメチアジドいずれかとの併用療法3群に割り付けられた。割付から8週間の降圧治療の結果、家庭血圧は有意な降圧を認め、UACRも有意に低下を認めた。しかしながら、家庭血圧の降圧度、およびUACRの低下率に3群間で有意差は認められなかった。本検討からは、腎機能改善効果における3剤の降圧薬いずれかの優位性は明らかとはならなかったが、いずれの降圧薬も家庭血圧降圧および腎機能改善に有用であることが改めて示された。 本研究結果は、微量アルブミン尿を呈する本態性高血圧患者における適正な降圧治療および降圧薬選択において重要な結果である。

  3. Early prevention strategy on lifestyle-related diseases regarding DOHaD based on self-measured home blood pressure

    Asayama Kei, KIKUYA Masahiro, TATSUTA Nozomi, IMAI Yutaka, OHKUBO Takayoshi, SATOH Hiroshi, NAKAI Kunihiko, Staessen Jan A., Thijs Lutgarde

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    2011/04/01 - 2016/03/31

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    The Tohoku Study of Child Development (TSCD) is a prospective birth cohort consisted of two areas in Japan. We measured home blood pressure of the mothers and of their 7-year-old children who participated in the TSCD for 2 weeks. We found that (1) breastfeeding has a protective effect against elevated blood pressure even in young children, and subtle, but important, differences were precisely detected by self-measurements performed at home, and (2) maternal pregnancy-induced hypertension (PIH) did not affect home blood pressure in offspring, but strongly affected maternal home blood pressure even 7 years after giving birth. From the longitudinal Ohasama cohort study, impacts of partial white-coat hypertension as well as partial masked hypertension for stroke risk were comparable to those of complete masked hypertension or sustained hypertension. Based on these 2 studies, we have unveiled further usefulness of self-measured home blood pressure.