Details of the Researcher

PHOTO

Shunji Kato
Section
Graduate School of Agricultural Science
Job title
Associate Professor
Degree

Research History 7

  • 2022/04 - Present
    東北大学大学院 農学研究科　J-オイルミルズ油脂イノベーション共同研究講座　准教授

  • 2019/04 - 2022/03
    Tohoku University

  • 2017/04 - 2019/03
    Tokai University　School of Medicine

  • 2016/04 - 2017/03
    東北大学大学院　農学研究科 機能分子解析学　教育研究支援者

  • 2015/04 - 2016/03
    Nippon Medical School

  • 2014/10 - 2015/03
    Sendai Shirayuri Women's College

  • 東北大学大学院　農学研究科 機能分子解析学　産学連携研究員

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Education 3

  • 東北大学大学院　農学研究科　博士後期課程

    2011/04 - 2014/03

  • 東北大学大学院　農学研究科　博士前期課程

    2009/04 - 2011/03

  • Hirosaki University　Faculty of Agriculture and Life Science

    2005/04 - 2009/03

Research Interests 6

  • 量子化学

  • 光学

  • 酸化ストレス

  • 過酸化脂質

  • 質量分析

  • 分析化学

Research Areas 2

  • Life sciences / Bioorganic chemistry /

  • Life sciences / Food sciences /

Awards 20

  1. 日本農芸化学会奨励賞

    2025/03　日本農芸化学会　過酸化脂質の超高精度分析技術の開発と量子化学の融合による脂質の酸化経路解明に向けた研究

  2. 日本農芸化学会東北支部奨励賞

    2024/09　日本農芸化学会　酸化脂質の精密構造解析による脂質酸化経路の解明

  3. 技術賞

    2024/05　日本栄養食糧学会

  4. BBB論文賞

    2024/03　日本農芸化学会

  5. 第11回若手研究者奨励賞

    2024/01　公益社団法人日本油化学会

  6. Award of the JOCS’s Selected Lecture

    2023/09　公益社団法人日本油化学会

  7. RSC Advances Award

    2022/08　2nd World Congress on Oleo Science

  8. WCOS2022 Excellent Presentation Award

    2022/08　2nd World Congress on Oleo Science

  9. 若手研究者奨励賞

    2018/09　日本油化学会関東支部　多様なトリアシルグリセロール分子種から成る油脂の初期酸化メカニズム解析

  10. ポスター賞

    2018/01　ビタミンE研究会　質量分析を用いた様々な脂質クラスの酸化機構の解析

  11. Poster Award

    2017/09　The Asian Conference on Oleo Science 2017 (ACOS2017)　Determination of triacylglycerol oxidation mechanisms using liquid chromatography-tandem mass spectrometry

  12. 若手奨励賞

    2016/11　平成28年度食品科学工学会東北支部大会　質量分析を用いた酸化油脂の高感度定量と酸化原因の特定

  13. ポスター企業賞

    2016/08　食品科学工学会第63回大会　質量分析を用いた食用油脂酸化の新規評価法の構築

  14. 若手優秀賞

    2016/08　日本過酸化脂質抗酸化物質学会第24回年会　リポタンパクの酸化機構とそれに関わる血漿の性質

  15. 若手奨励賞

    2014/10　農芸化学会東北支部　質量分析を用いた新規酸化ストレス評価法の構築-過酸化リン脂質の異性体定量に着目して-

  16. ICFHN Poster Award

    2014/10　ICFHN2014　Evaluation of oxidative stress by LC-MS/MS determination of peroxidized phospholipid isomers

  17. 若手優秀発表賞

    2014/10　第87回日本生化学会大会　LC-MS/MS によるヒト血漿過酸化リン脂質異性体の解析

  18. ヤングフェロー賞

    2014/09　日本油化学会第53回年会　LC-MS/MSによる生体過酸化リン脂質（PCOOH）の異性体解析

  19. 学生奨励賞

    2013/09　日本油化学会第52回年会　質量分析を用いたヒト血漿中過酸化リン脂質の精密定量

  20. Poster Award

    2012/05　103rd AOCS Annual Meeting & Expo　LC-MS/MS determination of phosphatidylcholine hydroperoxide in human plasma

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Papers 74

  1. Structural Analysis of Lipid Hydroperoxides Using Mass Spectrometry with Alkali Metals. International-journal Peer-reviewed

    Shunji Kato, Naoki Shimizu, Yusuke Ogura, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Shigefumi Kuwahara, Susumu Takekoshi, Jun Imagi, Kiyotaka Nakagawa

    Journal of the American Society for Mass Spectrometry　32　(9)　2399-2409　2021/09/01

    DOI： 10.1021/jasms.1c00039 　

    ISSN： 1879-1123 1044-0305

  2. Real-time assessment and future forecasting of extra virgin olive oil oxidation using near-infrared spectroscopy throughout shelf life

    Ibuki Kusumoto, Shunji Kato, Daitaro Ishikawa, Yurika Otoki, Yukihiro Ozaki, Kiyotaka Nakagawa

    FOOD CONTROL　187　2026/09

    DOI： 10.1016/j.foodcont.2026.112099 　

    ISSN： 0956-7135

    eISSN： 1873-7129

  3. The Oxidation Mechanisms of Saturated Fatty Acids: Formation of Hydroperoxide Isomers and Production of 2-Alkanones and Lactones

    Kanji Aoyagi, Shunji Kato, Kiyotaka Nakagawa

    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY　103　(8)　945-955　2026/08

    DOI： 10.1002/aocs.70110 　

    ISSN： 0003-021X

    eISSN： 1558-9331

  4. Double-bond geometry determines fatty acid metabolic fate and ferroptosis sensitivity. International-journal

    Cynthia A Harris, Shunji Kato, Yurika Otoki, Elisa Martin Perez, Dylan Boone, Juan Lorenzo B Pablo, Anna Greka, James A Olzmann

    bioRxiv : the preprint server for biology　2026/07/20

    DOI： 10.64898/2026.07.17.739092 　

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    Ferroptosis is driven by the accumulation of oxidatively damaged membrane phospholipids, making membrane lipid composition a central determinant of cell death sensitivity. While fatty acid chain length and degree of unsaturation are well-established regulators of ferroptosis, whether fatty acid stereochemistry contributes to ferroptosis susceptibility is mostly unexplored. Here, we systematically screened structurally diverse fatty acids for their ability to modulate ferroptosis and unexpectedly identified trans-unsaturated fatty acids as potent sensitizers. Compared with its cis counterpart linoleic acid, the trans polyunsaturated fatty acid (PUFA) linoelaidic acid more strongly enhanced lipid peroxidation and promoted the accumulation of ferroptosis-susceptible phospholipid species. Unexpectedly, the trans monounsaturated fatty acid petroselaidic acid also sensitized cells to ferroptosis, whereas its cis stereoisomer petroselinic acid suppressed ferroptosis. Mechanistically, petroselaidic acid required stearoyl-CoA desaturase-dependent conversion to a PUFA, directly demonstrating that double-bond geometry can redirect fatty acid metabolic fate through altered recognition by lipid metabolic enzymes. Although linoelaidic acid and petroselaidic acid followed distinct metabolic pathways, both converged on phospholipid remodeling that expanded pools of ferroptosis-susceptible membrane lipids. Together, our findings demonstrate that fatty acid double-bond geometry determines their metabolic fate and the membrane phospholipid composition, establishing lipid stereochemistry as a previously unrecognized structural determinant of ferroptosis sensitivity.

  5. Rapid and Non‐Destructive Quantification of Trace‐Level Lignans in Sesame Oil Using <scp>FT</scp> ‐ <scp>NIR</scp> Spectroscopy and Chemometric Modeling

    Yurika Otoki, Sho Ogisu, Shiori Watanabe, Shunji Kato, Daitaro Ishikawa, Kenichi Miyazaki, Yukihiro Ozaki, Kiyotaka Nakagawa

    Journal of the American Oil Chemists' Society　2026/04/16

    Publisher: Wiley

    DOI： 10.1002/aocs.70090 　

    ISSN： 0003-021X

    eISSN： 1558-9331

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    ABSTRACT Lignans are bioactive polyphenols in sesame oil that contribute to its antioxidant and metabolic health benefits. Their composition changes drastically during roasting and refining, but conventional methods such as HPLC–UV are time‐consuming and require organic solvents. Here, we established a rapid and non‐destructive near‐infrared (NIR) spectroscopic method coupled with partial least squares regression (PLSR) to simultaneously quantify six lignan species—sesamin, sesamolin, episesamin, diasesamin, sesaminol, and sesamol—in sesame oil. A total of 100 samples, including both roasted and refined oils, were analyzed. Reference data were obtained by HPLC–UV, and PLSR models were constructed using second‐derivative NIR spectra. The models achieved excellent predictive accuracy ( R 2  = 0.970–0.996; RMSE = 0.0008%–0.020%), even for trace‐level lignans such as sesamol (0.005%–0.03%) and diasesamin (&lt; 0.04%). The approach successfully distinguished structurally similar lignans and revealed spectral regions (around 7400 cm −1 ) linked to processing‐induced compositional changes. The proposed method provides a powerful, solvent‐free platform for rapid lignan profiling, allowing analysis within minutes without sample pretreatment, and offers strong potential for industrial quality control and process monitoring.

  6. Mechanistic Principles of Lipid Oxidation: From Hydroperoxide Formation to Secondary Oxidation Reactions. International-journal

    Shunji Kato

    Bioscience, biotechnology, and biochemistry　2026/04/14

    DOI： 10.1093/bbb/zbag053 　

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    Lipid oxidation plays crucial roles in both food deterioration and biological processes. Despite extensive studies, the mechanistic principles governing the formation of oxidized lipids remain incompletely understood, largely due to the remarkable structural diversity of oxidation products. In this review, we discuss lipid oxidation from the perspective of chemical reactivity, focusing on the formation and decomposition of lipid hydroperoxides (LOOH) as primary oxidation products. We summarize the major oxidation mechanisms determining the positional distribution of hydroperoxyl groups, including radical, enzymatic, and singlet oxygen-mediated pathways. Recent advances in liquid chromatography-tandem mass spectrometry for structural analysis of LOOH isomers are also reviewed. Particular attention is given to mechanistic principles governing secondary oxidation reactions, where decomposition pathways are largely dictated by radical intermediate stability and surrounding double-bond topology. Integrating structural analysis with stability-based mechanistic principles provides a framework for understanding lipid oxidation and predicting diverse oxidized lipid species.

  7. Discrimination of Lipid Hydroperoxide Positional Isomers Using <scp>SFC–</scp> <scp>MS</scp> / <scp>MS</scp> With Sodium Ion: Its Application to Evaluating the Oxidation Mechanisms of Oxidized Oils

    Ryosuke Aoki, Masayoshi Sakaino, Junya Ito, Shunji Kato, Jun Imagi, Toshiro Sato, Kiyotaka Nakagawa

    Journal of the American Oil Chemists' Society　2026/04/09

    Publisher: Wiley

    DOI： 10.1002/aocs.70089 　

    ISSN： 0003-021X

    eISSN： 1558-9331

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    ABSTRACT Advanced lipid profiling relies on liquid chromatography–tandem mass spectrometry (LC–MS/MS), but long analysis times remain a challenge. Supercritical fluid chromatography (SFC)–MS/MS using supercritical carbon dioxide offers a faster and more environmentally friendly alternative. However, the identification of positional isomers of oxidized lipids (lipid hydroperoxide [LOOH]) has not yet been achieved with SFC–MS/MS. Our research group has previously demonstrated that using sodium ion in LC–MS/MS induces specific fragmentation at the hydroperoxide group of LOOH, enabling the discrimination of LOOH positional isomers. This is essential information for identifying oxidation mechanisms such as autoxidation and photo–oxidation. In this study, we applied this method to SFC–MS/MS and attempted to distinguish six positional isomers of ethyl linoleate hydroperoxide (ELAOOH). Under non–column conditions, flow injection analysis with sodium acetate addition revealed the formation of sodium adducts of ELAOOH and specific fragmentation at the hydroperoxy group. Subsequent column evaluation showed that an octadecylsilane (ODS) column provided almost no retention, whereas Inertsil ODS–EP, which is an ODS column with a polar functional group, allowed good retention and separation. Through optimization, we successfully analyzed all six ELAOOH positional isomers. Finally, we analyzed canola oil that had undergone autoxidation or photo–oxidation under optimized conditions. In autoxidation, ELAOOH isomers with hydroperoxy groups at the 9– and 13–positions increased, while in photo–oxidation, isomers were generated at the 10– and 12–positions. These profiles demonstrated that the optimized SFC–MS/MS method using sodium ion can identify lipid oxidation mechanisms in actual samples. This method has the potential to become a powerful and environmentally friendly tool that can provide valuable information on lipid oxidation while significantly reducing the use of organic solvents compared to conventional methods.

  8. Elucidating the antioxidative mechanisms by blending rice bran oil with canola oil at ambient temperature. International-journal

    Shota Koishi, Sari Honda, Midori Matsuki, Kazue Sawada, Hiroyuki Hashimoto, Yuki Kadono, Halida Rahmania, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

    Food research international (Ottawa, Ont.)　221　(Pt 4)　117509-117509　2025/12

    DOI： 10.1016/j.foodres.2025.117509 　

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    Oil blending is a useful way to modify the unique properties of vegetable oils such as oxidative stability. Rice bran oil (RBO) has excellent oxidative stability due to its fatty acid (FA) composition with relatively more saturated FA and less polyunsaturated FA along with a variety of antioxidants and is therefore expected to be used in blend with other vegetable oils. However, there are limited studies demonstrating the benefits of blending RBO. Our earlier study revealed that blending RBO, even with a small amount, can significantly suppress volatile aldehydes (propanal and acrolein) during oxidation, especially at ambient temperature (around 40 °C). In this study, the potential antioxidative effect and mechanism responsible for the prior condition were investigated using canola oils (CO) blended with two types of RBO (original form and antioxidant-stripped), focusing on oxidation products (aldehyde and hydroperoxide), unoxidized FAs, and antioxidants (tocopherol (Toc), tocotrienol (T3), and γ-oryzanol (OZ)). The results showed that aldehydes, hydroperoxides (peroxide value), and FA degradation were significantly suppressed in CO blended with 10 % RBO but not with 10 % antioxidant-stripped RBO during oxidation at 40 °C. The analysis of triacylglycerol hydroperoxide isomers and antioxidant profile revealed that blending RBO could preserve the antioxidant activity (proton donation ability) and maintain Toc. This might be attributed to the maintained antioxidant activity of primary antioxidants (Toc), possibly sustained by other certain antioxidants in RBO (e.g., OZ). Consequently, RBO-blended oil exhibited prolonged antioxidant activity, especially at ambient temperature, demonstrating a promising practice to extend shelf-life across multiple applications.

  9. Well-to-well transfer of HaloTag ligand 6-chlorohexan-1-ol and formaldehyde in a multi-well plate. International-journal

    Yugo Mishima, Saori Yasuda, Aoi Kunitomi, Tokiha Masuda-Ozawa, Shusuke Tomoshige, Shunji Kato, Yuki Kadono, Kiyotaka Nakagawa, Minoru Ishikawa

    Scientific reports　16　(1)　2025/11/29

    DOI： 10.1038/s41598-025-29372-w 　

    ISSN： 2045-2322

  10. FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis. International-journal

    Mike Lange, Michele Wölk, Vivian Wen Li, Cody E Doubravsky, Joseph M Hendricks, Shunji Kato, Yurika Otoki, Benjamin Styler, Sean L Johnson, Cynthia A Harris, Kiyotaka Nakagawa, Isabel F Snodgrass, Dohee Kim, John W Newman, Maria Fedorova, James A Olzmann

    Nature cell biology　27　(11)　1902-1913　2025/11

    DOI： 10.1038/s41556-025-01790-y 　

    ISSN： 1465-7392

    eISSN： 1476-4679

  11. Effects of sodium chloride on the formation of 3-Monochloropropanediol esters in various meats and health risk assessment. International-journal

    Hao-Ting Chen, Chui Xuan Tan, Jiun-Rong Chen, Kiyotaka Nakagawa, Shunji Kato, Wei-Ju Lee

    Food chemistry: X　29　102754-102754　2025/07

    DOI： 10.1016/j.fochx.2025.102754 　

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    3-Monochloropropanediol esters (3-MCPDEs) are contaminants formed during high-temperature cooking and oil refining. While meat products are a source of 3-MCPDE exposure, related risk assessments remain limited. This study analyzed 3-MCPDE levels in pan-fried marinated meats (pork, chicken, beef, and salmon, with 0-10 % NaCl) using gas chromatography-mass spectrometry (GC-MS) following American Oil Chemists' Society (AOCS) Cd 29a-13 and assessed exposure in the Taiwanese population. Salt addition and higher unsaturation promoted lipid oxidation, increasing 3-MCPDE formation. Strong correlations (R > 0.9) were found between 3-MCPDE contents and total oxidation (totox) values across different meat types. Pork, with the highest fat content, had the highest 3-MCPDE levels, followed by salmon. Exposure assessments showed 3-MCPDE intake remained below the tolerable daily intake (TDI), with pork being the largest contributor. The highest P95 exposure from four meat types with 10 % NaCl reached 41.35 % of the TDI, suggesting potential risk when combined with other dietary sources.

  12. Relationship between the Particle Size and the Oxidative Stability of Aqueous Emulsion Prepared from Triacylglycerol Rich in Docosahexaenoic Acid.

    Yumi Sato-Ishizaki, Atsuhiro Iguchi, Keita Someya, Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa, Naohiro Gotoh

    Journal of oleo science　74　(8)　729-737　2025

    DOI： 10.5650/jos.ess25092 　

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    The oxidative stability of polyunsaturated fatty acid (PUFA) generally decreases with increasing unsaturation, however, the opposite results have been reported for aqueous emulsions prepared from PUFA. One study showed that among PUFA (fish oil) emulsions with varying μm-sized particles, the smaller emulsions had better oxidation stability. Thus, particle size may be involved in the mechanism behind the improved oxidative stability of PUFA by emulsification, and PUFA emulsions with even smaller particle sizes (i.e., nm-sized) may exhibit higher stability. To evaluate these hypotheses, once optimizing conditions under which emulsions with different sizes (100-250 nm) can be prepared using docosahexaenoic acid (DHA)-rich algal oil (DAO), these emulsions were subjected to thermal oxidation (40°C, 5 days under light shielding). Based on peroxide value (POV) data, it is apparent that even DHA, which is particularly prone to oxidation, becomes less susceptible to thermal oxidation when emulsified, and that smaller emulsions lead to greater oxidative stability. The high oxidation stability in the smallest emulsion remained high after removal of the antioxidants (tocopherols) from this emulsion. Considering these results together with preliminary data on triacylglycerol (TG) mono-hydroperoxides measured by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS), the physical properties of the emulsion might account for the greater oxidative stability in smaller emulsions, probably due to the rapid termination of the oxidation reaction within the smaller particle in a more substrate-dense environment, rather than to the action of antioxidant tocopherols. Further research will hopefully lead to a solution to the longstanding problem of oxidation of PUFA such as DHA, which has a variety of benefits.

  13. Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomers. International-journal

    Yurika Otoki, Daitaro Ishikawa, Shunji Kato, Ibuki Kusumoto, Yukihiro Ozaki, Kiyotaka Nakagawa

    Food chemistry　467　142143-142143　2024/11/27

    DOI： 10.1016/j.foodchem.2024.142143 　

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    Monitoring oxidation causes (i.e. radical and/or photo-oxidation) of vegetable oil gives very important information for its quality control. This study aimed to develop a rapid and simple near infrared (NIR) spectroscopy method to explore the oxidation causes in vegetable oil by quantifying triacylglycerol hydroperoxide (TGOOH) positional isomers proceeded by different oxidation causes. First, the concentrations of TGOOH isomers were determined by liquid chromatography-mass spectrometry. Partial least square regression for concentrations of TGOOH isomers (R2: 0.994-0.998) using NIR spectra in the regions of 7500-6000 cm-1 and 5500-4500 cm-1 as explanatory variables. Principal component analysis revealed that those models were created because NIR spectra capture trace changes of the peak around 6980 cm-1(-CH2-) and 5260 cm-1 (H2O) derived by different oxidation causes (i.e. radical and/or photo-oxidation). The application of this method to various kinds of vegetable oil is expected to lead to a simple and rapid quality evaluation of vegetable oil.

  14. Effects of Different Manufacturing Processes on Thermal and Photo-oxidative Stability of Sesame Oil.

    Halida Rahmania, Tomomi Nakanishi, Satomi Oi, Rika Onishi, Eiichiro Yamagami, Kazuyuki Yamane, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

    Journal of oleo science　73　(10)　1267-1276　2024/09/20

    DOI： 10.5650/jos.ess24084 　

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    The roasting process of sesame oil is expected to alter its internal composition and stability under oxidation condition. Presumably, the effect of roasting may differ with oxidation conditions (i.e., thermal and photo-oxidation), but such studies have not been undertaken. To further evaluate this notion, several type of sesame oils (raw and refined as unroasted oil, and roasted oil) and rapeseed oils as comparison were subjected to thermal oxidation (120℃) and photo-oxidation (50,000 lx) for 5 and 10 hours. The result revealed that the roasting sesame oil exhibited good stability under thermal oxidation, possibly due to the change on antioxidant agents such as sesamol and Maillard products during the roasting process. In contrast, the refined sesame oil (unroasted) demonstrated high stability under photo-oxidation, indicating that the refining process has a more significant impact on the oxidative stability in sesame oil compared to the alterations in its components caused by the roasting process. Taken together, this study is the first to show that the roasting and refining processes of sesame oil alter its internal composition and show different variations in sesame oils' oxidative stability under thermal and photo-oxidation, which holds significance considering its global consumption.

  15. Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation Peer-reviewed

    Tokuko Takajo, Koichi Saito, Kazunori Tsuchida, Shunji Kato, Kiyotaka Nakagawa, Akitoshi Okino, Kazunori Anzai

    Journal of Clinical Biochemistry and Nutrition　75　(3)　183-189　2024/08

    DOI： 10.3164/jcbn.24-72 　

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    Liposome lipid peroxidation induced by cold atmospheric pressure plasma jet (CAPPJ) irradiation was investigated. The formation of thiobarbituric acid reactive substances (TBARS), an indicator of lipid peroxidation final products, as a function of irradiation was observed. Lipid radicals, peroxidation reaction intermediates generated by CAPPJ irradiation, were confirmed by increased NBD-pen fluorescence intensity. Additionally, lipid peroxidation products, liposomal phosphatidylcholine (PC) isomers, were analyzed by LC-MS/MS. Products specific to singlet oxygen (1O2) oxidation, 16:0/10-hydroperoxy-8E,12Z-octadecanoic acid (10-8E,12Z-HpODE) PC and 16:0/12-9E,13E-HpODE PC, were not detected, but radical oxidation specific products 16:0/13-9E,11E-HpODE PC and 16:0/9-10E,12E-HpODE PC were. This suggests that during CAPPJ irradiation, radicals, rather than 1O2, are the primary reactive species of lipid peroxidation. This is also supported by the β-carotene quenching of 1O2 not suppressing TBARS and lipid radical generation. Also, neither TBARS formation nor lipid radical generation were suppressed by SOD, indicating that the superoxide radical (O2 •-) is not responsible for the lipid peroxidation reaction. As the CAPPJ irradiation of water produces large quantities of hydroxyl radical (•OH) and •OH scavengers decreased the amount of TBARS produced by CAPPJ irradiation, it is highly plausible that •OH is the primary species involved in CAPPJ-induced liposome lipid peroxidation.

  16. Corrigendum to "Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products - 2-alkanones and lactones" [Food Chem.: X 21 (2024) 101074]. International-journal

    Kanji Aoyagi, Shunji Kato, Daisuke Isaka, Yoshinori Sekiguchi, Yurika Otoki, Hidetaka Uehara, Kiyotaka Nakagawa

    Food chemistry: X　21　101131-101131　2024/03/30

    DOI： 10.1016/j.fochx.2024.101131 　

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    [This corrects the article DOI: 10.1016/j.fochx.2023.101074.].

  17. Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products - 2-alkanones and lactones. International-journal Peer-reviewed

    Kanji Aoyagi, Shunji Kato, Daisuke Isaka, Yoshinori Sekiguchi, Yurika Otoki, Hidetaka Uehara, Kiyotaka Nakagawa

    Food chemistry: X　21　101074-101074　2024/03/30

    DOI： 10.1016/j.fochx.2023.101074 　

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    As known for quite a long time now, even saturated fatty acids can be oxidized at high temperatures to produce unique aroma compounds, such as 2-alkanones and lactones. Hydroperoxide positional isomers with a hydroperoxy group at the 2-, 3-, 4-, or 5-position are hypothesized to be responsible for the formation of these aroma components, but this hypothesis has not been verified. For the first time, this study successfully prepared a series of glyceryl trioctanoate hydroperoxide (C8TG;OOH) isomers. The isomers were thermally decomposed, proving that 2-heptanone was selectively formed from C8TG;3-OOH, and γ- and δ-octalactones were mainly formed from C8TG;4- and 5-OOH, respectively. C8TG;2-OOH was also involved in lactone formation, whereas C8TG;6- and 7-OOH were not. This proves the long-standing hypothesis. The mechanism revealed in this work is expected to be useful to create favorable aromas (i.e., 2-alkanones and lactones) from saturated fatty acids.

  18. Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts. International-journal Peer-reviewed

    Chikara Kato, Ibuki Kusumoto, Shunji Kato, Yurika Otoki, Junya Ito, Hirono Totsuka, Arun Rajgopal, Jina Hong, Kiyotaka Nakagawa

    Biochemical and biophysical research communications　698　149553-149553　2024/02/26

    DOI： 10.1016/j.bbrc.2024.149553 　

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    Ever since the proposal of ferroptosis, it has been studied as a nonapoptotic cell death caused by iron ion-dependent phospholipid (PL) peroxidation. We previously showed that treatment of human hepatoma cell line HepG2 with prepared PL hydroperoxide (PLOOH) resulted in ferroptosis. However, in human sebum, the major hydroperoxide is not PLOOH but squalene hydroperoxide (SQOOH), and to our knowledge, it is not established yet whether SQOOH induces ferroptosis in the skin. In this study, we synthesized SQOOH and treated human keratinocyte HaCaT cells with SQOOH. The results showed that SQOOH induces ferroptosis in HaCaT cells in the same way that PLOOH causes ferroptosis in HepG2 cells. Some natural antioxidants (botanical extracts) could inhibit the ferroptosis in both the cell types. Consequently, future research focus would revolve around the involvement of SQOOH-induced ferroptosis in skin pathologies as well as the prevention and treatment of skin diseases through inhibition of ferroptosis by botanical extracts.

  19. LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation International-journal Peer-reviewed

    Hirotada Saito, Shunji Kato, Naoki Shimizu, Takumi Takahashi, Mirinthorn Jutanom, Junya Ito, Satoshi Kasatani, Kiyotaka Nakagawa

    Food Research International　178　113913-113913　2024/02

    DOI： 10.1016/j.foodres.2023.113913 　

    ISSN： 0963-9969

    eISSN： 1873-7145

  20. Comparison of the Catabolic Rates of Linoleic and Oleic Acid Hydroperoxides Using 13CO2 Expired from Mice. Peer-reviewed

    Aya Yoshinaga-Kiriake, Kazuaki Yoshinaga, Sae Miyagawa, Kanako Yoshino, Seiya Tanaka, Takumi Takahashi, Shunji Kato, Junya Ito, Yurika Otoki, Kiyotaka Nakagawa, Naohiro Gotoh

    Journal of oleo science　73　(6)　847-855　2024

    DOI： 10.5650/jos.ess23236 　

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    Unsaturated fatty acids, such as oleic and linoleic acids, are easily oxidized by exposure to temperature and light in the presence of air to form unsaturated fatty acid hydroperoxides as primary oxidation products. However, the catabolic rates of unsaturated fatty acid hydroperoxides in the human body remain unknown. In this study, ethyl esters of 13C-labeled linoleic acid (*C18:2-EE) and oleic acid (*C18:1-EE) and their hydroperoxides (*C18:2-EE-OOH and *C18:1-EE-OOH, respectively) prepared by the photo-oxidation of *C18:2-EE and *C18:1-EE, respectively, were administered to mice and their catabolic rates were determined by measuring the expired 13CO2 levels. *C18:2-EE-OOH and *C18:1-EE-OOH were β-oxidized faster than *C18:2-EE and *C18:1-EE, respectively. Notably, rapid β-oxidation of *C18:2-EE-OOH and *C18:1-EE-OOH was similar to that of medium-chain fatty acids, such as octanoic acid. Then, degradation products of C18:2-EE-OOH and C18:1-EE-OOH were analyzed under gastric conditions by gas chromatography/mass spectrometry. Major decomposition products of C18:2-EE-OOH and C18:1-EE-OOH were medium-chain compounds, such as octanoic acid ethyl ester, 9-oxo-nonanoic acid ethyl ester, and 10-oxo-8-decenoic acid ethyl esters, indicating that C18:2-EE-OOH and C18:1-EE-OOH isomers formed during photo-oxidation were decomposed under acidic conditions. These findings support previous reports that dietary lipid hydroperoxides are not absorbed into the intestine as lipid hydroperoxides but as degradation products. This is the first study to suggest that dietary lipid hydroperoxides decompose during gastric digestion to form medium-chain compounds that are directly absorbed into the liver via the portal vein and rapidly catabolized via β-oxidation.

  21. Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models. International-journal Peer-reviewed

    Mirinthorn Jutanom, Shunji Kato, Shinji Yamashita, Masako Toda, Mikio Kinoshita, Kiyotaka Nakagawa

    Scientific reports　13　(1)　22537-22537　2023/12/18

    DOI： 10.1038/s41598-023-49521-3 　

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    Glucosylceramide (GlcCer) belongs to sphingolipids and is found naturally in plant foods and other sources that humans consume daily. Our previous studies demonstrated that GlcCer prevents inflammatory bowel disease both in vitro and in vivo, whose patients are increasing alarmingly. Although some lipids are vulnerable to oxidation which changes their structure and activities, it is unknown whether oxidative modification of GlcCer affects its activity. In this research, we oxidized GlcCer in the presence of a photosensitizer, analyzed the oxide by mass spectrometric techniques, and examined its anti-inflammatory activity in lipopolysaccharide (LPS)-treated differentiated Caco-2 cells as in vitro model of intestinal inflammation. The results showed that GlcCer is indeed oxidized, producing GlcCer hydroperoxide (GlcCerOOH) as a primary oxidation product. We also found that oxidized GlcCer preserves beneficial functions of GlcCer, suppressing inflammatory-related gene expressions. These findings suggested that GlcCerOOH may perform as an LPS recognition antagonist to discourage inflammation rather than induce inflammation.

  22. Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease. International-journal Peer-reviewed

    Yurika Otoki, Di Yu, Qing Shen, Demetrios J Sahlas, Joel Ramirez, Fuqiang Gao, Mario Masellis, Richard H Swartz, Pak Cheung Chan, Jacqueline A Pettersen, Shunji Kato, Kiyotaka Nakagawa, Sandra E Black, Walter Swardfager, Ameer Y Taha

    Journal of Alzheimer's disease : JAD　93　(2)　665-682　2023/04/17

    DOI： 10.3233/JAD-220795 　

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    BACKGROUND: Circulating phospholipid species have been shown to predict Alzheimer's disease (AD) prognosis but the link between phospholipid disturbances and subcortical small vessel cerebrovascular disease (CeVD) common in AD patients is not known. OBJECTIVE: This study used quantitative lipidomics to measure serum diacyl, alkenyl (ether), alkyl, and lyso phospholipid species in individuals with extensive CeVD (n = 29), AD with minimal CeVD (n = 16), and AD with extensive CeVD (n = 14), and compared them to age-matched controls (n = 27). Memory was assessed using the California Verbal Learning Test. 3.0T MRI was used to assess hippocampal volume, atrophy, and white matter hyperintensity (WMH) volumes as manifestations of CeVD. RESULTS: AD was associated with significantly higher concentrations of choline plasmalogen 18:0_18:1 and alkyl-phosphocholine 18:1. CeVD was associated with significantly lower lysophospholipids containing 16:0. Phospholipids containing arachidonic acid (AA) were associated with poorer memory in controls, whereas docosahexaenoic acid (DHA)-containing phospholipids were associated with better memory in individuals with AD+CeVD. In controls, DHA-containing phospholipids were associated with more atrophy and phospholipids containing linoleic acid and AA were associated with less atrophy. Lysophospholipids containing 16:0, 18:0, and 18:1 were correlated with less atrophy in controls, and of these, alkyl-phosphocholine 18:1 was correlated with smaller WMH volumes. Conversely, 16:0_18:1 choline plasmalogen was correlated with greater WMH volumes in controls. CONCLUSION: This study demonstrates discernable differences in circulating phospholipids in individuals with AD and CeVD, as well as new associations between phospholipid species with memory and brain structure that were specific to contexts of commonly comorbid vascular and neurodegenerative pathologies.

  23. Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography-mass spectrometry. International-journal Peer-reviewed

    Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

    Scientific reports　13　(1)　1325-1325　2023/01/24

    DOI： 10.1038/s41598-023-28514-2 　

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    Docosahexaenoic acid (DHA) is mostly esterified in food and is easily oxidized by exposure to heat or light. Hydroperoxide positions of DHA mono-hydroperoxide (DHA;OOH) provide information on oxidation mechanisms (e.g., radical- or singlet oxygen oxidation), yet direct identification of esterified DHA;OOH isomers has not been achieved. We previously accomplished the direct analysis of free DHA;OOH isomers with liquid chromatography-mass spectrometry (LC-MS/MS). In this study, we developed an LC-MS/MS method for direct analysis of esterified DHA;OOH based on our previous study. The developed method was capable of distinguishing esterified DHA;OOH isomers in raw- and oxidized mackerel. The result suggested that radical oxidation of esterified DHA can progress even in refrigeration. Different transitions were observed depending on the oxidation mechanism and lipid class. The analytical method and insights obtained in this study would be valuable to further understand and effectively prevent DHA oxidation in food products.

  24. Cellular Uptake of Pyrroloquinoline Quinone in Its Intact and Derivatized Forms from the Cell Culture Medium of 3T3-L1. Peer-reviewed

    Chikara Kato, Isabella Supardi Parida, Satoshi Maeda, Tsuyoshi Mikekado, Shunji Kato, Susumu Takekoshi, Kiyotaka Nakagawa

    Journal of oleo science　71　(12)　1761-1767　2022/12/03

    DOI： 10.5650/jos.ess22284 　

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    Following a growing interest in the physiological effects of pyrroloquinoline quinone (PQQ), more cell culture experiments have begun to elucidate its mechanism of action. However, to our knowledge, no reports have used instrumental analysis, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), to study cellular uptake of PQQ. In addition, despite the propensity of PQQ to react with amino acids and other compounds, only a handful of cell culture experiments have been conducted on PQQ derivatives. In the present study, we prepared PQQ derivatives by reacting PQQ with various amino acids and used them as reference standards for optimizing the LC-MS/MS analysis conditions to detect PQQ and its derivatives. Using this method, we evaluated the uptake of PQQ into mouse 3T3-L1 cells and found that most PQQ added to the medium was taken up by the cells in its unchanged form, while some PQQ reacted with amino acids in the medium and was taken up by the cells as PQQ derivatives. These results suggest that PQQ derivatives may contribute to the physiological effects of PQQ. To further elucidate the function of PQQ, it is necessary for future studies to clarify the activity of PQQ derivatives and to evaluate the types of PQQ present in food, animal, and cell samples in more detail.

  25. Elucidation of decomposition pathways of linoleic acid hydroperoxide isomers by GC-MS and LC-MS/MS. International-journal Peer-reviewed

    Ruriko Miyazaki, Shunji Kato, Yurika Otoki, Halida Rahmania, Masayoshi Sakaino, Shigeo Takeuchi, Toshiro Sato, Jun Imagi, Kiyotaka Nakagawa

    Bioscience, biotechnology, and biochemistry　87　(2)　179-190　2022/11/23

    DOI： 10.1093/bbb/zbac189 　

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    Food lipid oxidation provides various volatile compounds involved in food flavor via the decomposition of lipid hydroperoxide (LOOH). This study predicted the pathways which can coherently explain LOOH decomposition focusing on hydroperoxy octadecadienoic acid (HpODE) isomers (9-EZ-HpODE, 9-EE-HpODE, 10-HpODE, 12-HpODE, 13-ZE-HpODE, and 13-EE-HpODE) which are the major LOOH contained in edible oils. Each standard was firstly prepared and thermally decomposed. Generated volatile and non-volatile compounds were analyzed by GC-MS and LC-MS/MS. The results showed that all HpODE decomposition was based on the factors such as favorable scission, radical delocalization, and cyclization. Interestingly, the formation of 8-HpODE and 14-HpODE were demonstrated during HpODE decomposition. The insights obtained in this study would explain the generation pathways of flavor involved in food quality.

  26. Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to Ferroptosis. Peer-reviewed

    Chikara Kato, Yuuri Suzuki, Isabella Supardi Parida, Shunji Kato, Hiroyuki Yamasaki, Susumu Takekoshi, Kiyotaka Nakagawa

    Journal of oleo science　71　(11)　1689-1694　2022/10/28

    DOI： 10.5650/jos.ess22281 　

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    Ferroptosis is mainly caused by iron-mediated peroxidation of phospholipids and has recently attracted attention due to its involvement in various diseases. At the center of it is supposedly the inability of glutathione peroxidase 4 (GPX4) to reduce excess peroxidized phospholipids (e.g., phosphatidylcholine hydroperoxide (PCOOH)) that trigger ferroptosis. However, the involvement of enzymes other than GPX4 in ferroptosis is scarcely known. To elucidate this matter, we evaluated the uptake of PCOOH in a GPX4 knockout (KO) human hepatoma cell line HepG2 generated using CRISPR-Cas9. After confirming that GPX4 expression in the KO cells was below the detection limit, we cultured both wild-type (WT) and GPX4 KO HepG2 cells in a medium containing 50 μM PCOOH for 1-8 hours. By analyzing the level of PCOOH and its reduction product (phosphatidylcholine hydroxide, PCOH) in cells using liquid chromatography-tandem mass spectrometry, we detected the cellular uptake of PCOOH. On top of this, we detected a large amount of PCOH not only in WT HepG2 but also in GPX4 KO HepG2, thus indicating the notable involvement of enzymes other than GPX4 (e.g., other GPX family, glutathione S-transferase, thioredoxin, or peroxiredoxin) in reducing PCOOH. Further corroboration of these findings hopefully leads to the development of novel methods to prevent ferroptosis-related diseases by targeting enzymes other than GPX4.

  27. Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract. International-journal Peer-reviewed

    Takumi Takahashi, Shunji Kato, Junya Ito, Naoki Shimizu, Isabella Supardi Parida, Mayuko Itaya-Takahashi, Masayoshi Sakaino, Jun Imagi, Kazuaki Yoshinaga, Aya Yoshinaga-Kiriake, Naohiro Gotoh, Ikuo Ikeda, Kiyotaka Nakagawa

    Redox biology　57　102471-102471　2022/09/14

    DOI： 10.1016/j.redox.2022.102471 　

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    The in vivo presence of triacylglycerol hydroperoxide (TGOOH), a primary oxidation product of triacylglycerol (TG), has been speculated to be involved in various diseases. Thus, considerable attention has been paid to whether dietary TGOOH is absorbed from the intestine. In this study, we performed the lymph duct-cannulation study in rats and analyzed the level of TGOOH in lymph following administration of a TG emulsion containing TGOOH. As we successfully detected TGOOH from the lymph, we hypothesized that this might be originated from the intestinal absorption of dietary TGOOH [hypothesis I] and/or the in situ formation of TGOOH [hypothesis II]. To determine the validity of these hypotheses, we then performed another cannulation study using a TG emulsion containing a deuterium-labeled TGOOH (D2-TGOOH) that is traceable in vivo. After administration of this emulsion to rats, we clearly detected unlabeled TGOOH instead of D2-TGOOH from the lymph, indicating that TGOOH is not absorbed from the intestine but is more likely to be produced in situ. By discriminating the isomeric structures of TGOOH present in lymph, we predicted the mechanism by which the intake of dietary TGOOH triggers oxidative stress (e.g., via generation of singlet oxygen) and induces in situ formation of TGOOH. The results of this study hereby provide a foothold to better understand the physiological significance of TGOOH on human health.

  28. Elucidation of Olive Oil Oxidation Mechanisms by Analysis of Triacylglycerol Hydroperoxide Isomers Using LC-MS/MS. International-journal Peer-reviewed

    Hayato Takahashi, Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Jun Imagi, Kiyotaka Nakagawa

    Molecules (Basel, Switzerland)　27　(16)　2022/08/18

    DOI： 10.3390/molecules27165282 　

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    Despite the importance of the insight about the oxidation mechanisms (i.e., radical and singlet oxygen (1O2) oxidation) in extra virgin olive oil (EVOO), the elucidation has been difficult due to its various triacylglycerol molecular species and complex matrix. This study tried to evaluate the mechanisms responsible for EVOO oxidation in our daily use by quantitative determination of triacylglycerol hydroperoxide (TGOOH) isomers using LC-MS/MS. The standards of dioleoyl-(hydroperoxy octadecadienoyl)-triacylglycerol and dioleoyl-(hydroperoxy octadecamonoenoyl)-triacylglycerol, which are the predominant TGOOHs contained in EVOO, were prepared. Subsequently, fresh, thermal-, and photo-oxidized EVOO were analyzed. The obtained results mostly agreed with the previously reported characteristics of the radical and 1O2 oxidation of linoleic acid and oleic acid. This suggests that the methods described in this paper should be valuable in understanding how different factors that determine the quality of EVOO (e.g., olive species, cultivation area, cultivation timing, and extraction methods) contribute to its oxidative stability.

  29. Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils. International-journal Peer-reviewed

    Masayoshi Sakaino, Takashi Sano, Shunji Kato, Naoki Shimizu, Junya Ito, Halida Rahmania, Jun Imagi, Kiyotaka Nakagawa

    Scientific reports　12　(1)　12460-12460　2022/07/21

    DOI： 10.1038/s41598-022-15627-3 　

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    Acid value (AV), is a widely used indicator of oil degradation that, by definition, measures the free fatty acids formed via the hydrolysis of triacyclglycerols. However, based on observations made in previous studies, we hypothesized that the oxidation of triacylglycerols leads to the formation of carboxylic acids with a glycerol backbone which are also calculated as AV. In this study, we aimed to identify such carboxylic acids and prove the above hypothesis. Heating a canola oil at 180 °C for 6 h without the addition of water resulted in an increase in AV from 0.054 to 0.241. However, the contribution of free fatty acids to this increase in AV was minimal; free fatty acid-derived AV before and after heating was 0.020 and 0.023, respectively. Then, via mass spectrometric analyses, we identified two 8-carboxy-octanoyl (azelaoyl) -triacylglycerols (i.e., dioleoyl-azelaoyl-glycerol and oleoyl-linoleoyl-azelaoyl-glycerol) in the heated oil. Azelaoyl-triacylglycerols-derived AV before and after heating the oil was 0.008 and 0.109, respectively, demonstrating that azelaoyl-triacylglycerols contribute to AV. Such an increase in AV by azelaoyl-triacylglycerols was also observed in an oil used to deep-fry potatoes (i.e., an oil with a relatively high water content). These results suggest that AV is also an indicator of the thermal oxidation of triacylglycerols.

  30. Determination of acrolein generation pathways from linoleic acid and linolenic acid: increment by photo irradiation. International-journal Peer-reviewed

    Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Shigeo Takeuchi, Jun Imagi, Kiyotaka Nakagawa

    NPJ science of food　6　(1)　21-21　2022/04/12

    DOI： 10.1038/s41538-022-00138-2 　

    ISSN： 2396-8370

  31. Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage. International-journal International-coauthorship Peer-reviewed

    Jeremy P Koelmel, Wan Y Tan, Yang Li, John A Bowden, Atiye Ahmadireskety, Andrew C Patt, David J Orlicky, Ewy Mathé, Nicholas M Kroeger, David C Thompson, Jason A Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D Guingab-Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Richard A Yost, Timothy J Garrett, Vasilis Vasilou

    Hepatology communications　6　(3)　513-525　2021/11/23

    DOI： 10.1002/hep4.1825 　

    ISSN： 2471-254X

  32. Novel Photoinduced Squalene Cyclic Peroxide Identified, Detected, and Quantified in Human Skin Surface Lipids Peer-reviewed

    Saoussane Khalifa, Masaru Enomoto, Shunji Kato, Kiyotaka Nakagawa

    Antioxidants　10　(11)　1760-1760　2021/11/04

    Publisher: MDPI AG

    DOI： 10.3390/antiox10111760 　

    ISSN： 2076-3921

    eISSN： 2076-3921

  33. Investigation of Lipoproteins Oxidation Mechanisms by the Analysis of Lipid Hydroperoxide Isomers. International-journal Invited Peer-reviewed

    Shunji Kato, Yusuke Osuka, Saoussane Khalifa, Takashi Obama, Hiroyuki Itabe, Kiyotaka Nakagawa

    Antioxidants (Basel, Switzerland)　10　(10)　2021/10/12

    DOI： 10.3390/antiox10101598 　

    ISSN： 2076-3921

  34. Linoleic acid and squalene are oxidized by discrete oxidation mechanisms in human sebum. International-journal Peer-reviewed

    Ayano Ishikawa, Junya Ito, Naoki Shimizu, Shunji Kato, Eri Kobayashi, Hiroki Ohnari, Osamu Sakata, Eiji Naru, Kiyotaka Nakagawa

    Annals of the New York Academy of Sciences　1500　(1)　112-121　2021/09

    Publisher: Annals of the New York Academy of Sciences

    DOI： 10.1111/nyas.14615 　

    ISSN： 1749-6632 0077-8923

  35. A Novel Technique for Redox Lipidomics Using Mass Spectrometry: Application on Vegetable Oils Used to Fry Potatoes. International-journal International-coauthorship Peer-reviewed

    Jeremy P Koelmel, Juan J Aristizabal-Henao, Zhixu Ni, Maria Fedorova, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Elizabeth Z Lin, Krystal J Godri Pollitt, Vasilis Vasiliou, Joy D Guingab, Timothy J Garrett, Traycie L Williams, John A Bowden, Meera Penumetcha

    Journal of the American Society for Mass Spectrometry　32　(7)　1798-1809　2021/07/07

    DOI： 10.1021/jasms.1c00150 　

    ISSN： 1879-1123 1044-0305

  36. Lipidomic Analysis of Postmortem Prefrontal Cortex Phospholipids Reveals Changes in Choline Plasmalogen Containing Docosahexaenoic Acid and Stearic Acid Between Cases With and Without Alzheimer's Disease. International-journal Peer-reviewed

    Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa, Danielle J Harvey, Lee-Way Jin, Britany N Dugger, Ameer Y Taha

    Neuromolecular medicine　23　(1)　161-175　2021/03

    DOI： 10.1007/s12017-020-08636-w 　

    ISSN： 1559-1174 1535-1084

  37. Structural changes of ethanolamine plasmalogen during intestinal absorption. International-journal Peer-reviewed

    Takumi Takahashi, Reina Kamiyoshihara, Yurika Otoki, Junya Ito, Shunji Kato, Takuji Suzuki, Shinji Yamashita, Takahiro Eitsuka, Ikuo Ikeda, Kiyotaka Nakagawa

    Food & function　11　(9)　8068-8076　2020/09/23

    DOI： 10.1039/d0fo01666g 　

    ISSN： 2042-6496

    eISSN： 2042-650X

  38. Revealing the thermal oxidation stability and its mechanism of rice bran oil. International-journal Peer-reviewed

    Halida Rahmania, Shunji Kato, Kazue Sawada, Chieko Hayashi, Hiroyuki Hashimoto, Shigeo Nakajima, Yurika Otoki, Junya Ito, Kiyotaka Nakagawa

    Scientific reports　10　(1)　14091-14091　2020/08/24

    DOI： 10.1038/s41598-020-71020-y 　

    ISSN： 2045-2322

  39. Direct Separation of the Diastereomers of Cholesterol Ester Hydroperoxide Using LC-MS/MS to Evaluate Enzymatic Lipid Oxidation Peer-reviewed

    Junya Ito, Naoki Shimizu, Shunji Kato, Yusuke Ogura, Kiyotaka Nakagawa

    Symmetry　12　(7)　1127-1127　2020/07/07

    Publisher: MDPI AG

    DOI： 10.3390/sym12071127 　

    ISSN： 2073-8994

    eISSN： 2073-8994

  40. Analysis of oxidation products of α-tocopherol in extra virgin olive oil using liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

    Rena Tanno, Shunji Kato, Naoki Shimizu, Junya Ito, Shuntaro Sato, Yusuke Ogura, Masayoshi Sakaino, Takashi Sano, Takahiro Eitsuka, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

    Food chemistry　306　125582-125582　2020/02/15

    DOI： 10.1016/j.foodchem.2019.125582 　

    ISSN： 0308-8146

  41. Evaluation of squalene oxidation mechanisms in human skin surface lipids and shark liver oil supplements. International-journal Peer-reviewed

    Naoki Shimizu, Junya Ito, Shunji Kato, Takahiro Eitsuka, Tetsuo Saito, Hiroshi Nishida, Teruo Miyazawa, Kiyotaka Nakagawa

    Annals of the New York Academy of Sciences　1457　(1)　158-165　2019/12

    Publisher: Annals of the New York Academy of Sciences

    DOI： 10.1111/nyas.14219 　

    ISSN： 0077-8923

  42. Evaluation of lipid oxidation mechanisms in beverages and cosmetics via analysis of lipid hydroperoxide isomers. International-journal Peer-reviewed

    Junya Ito, Marina Komuro, Isabella Supardi Parida, Naoki Shimizu, Shunji Kato, Yasuhiro Meguro, Yusuke Ogura, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

    Scientific reports　9　(1)　7387-7387　2019/05/14

    DOI： 10.1038/s41598-019-43645-1 　

    ISSN： 2045-2322

  43. Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol. International-journal Peer-reviewed

    Eri Kobayashi, Junya Ito, Naoki Shimizu, Takumi Kokumai, Shunji Kato, Kazue Sawada, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    Nutrients　11　(1)　2019/01/06

    DOI： 10.3390/nu11010104 　

    ISSN： 2072-6643

  44. Lipid oxidation: their structure and biological implication Peer-reviewed

    Shunji Kato, Junya Ito, Susumu Takekoshi, Kiyotaka Nakagawa

    43　(1)　13-20　2019/01

  45. Significance of Squalene in Rice Bran Oil and Perspectives on Squalene Oxidation. Peer-reviewed

    Naoki Shimizu, Junya Ito, Shunji Kato, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    Journal of nutritional science and vitaminology　65　(Supplement)　S62-S66-S66　2019

    DOI： 10.3177/jnsv.65.S62 　

    ISSN： 0301-4800

  46. Oxidation of squalene by singlet oxygen and free radicals results in different compositions of squalene monohydroperoxide isomers. International-journal Peer-reviewed

    Naoki Shimizu, Junya Ito, Shunji Kato, Yurika Otoki, Masashi Goto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    Scientific reports　8　(1)　9116-9116　2018/06/14

    DOI： 10.1038/s41598-018-27455-5 　

    ISSN： 2045-2322

  47. Development of quantitation method for glycated aminophospholipids at the molecular species level in powdered milk and powdered buttermilk. International-journal Peer-reviewed

    Ai Kodate, Yurika Otoki, Naoki Shimizu, Junya Ito, Shunji Kato, Naoki Umetsu, Teruo Miyazawa, Kiyotaka Nakagawa

    Scientific reports　8　(1)　8729-8729　2018/06/07

    DOI： 10.1038/s41598-018-27010-2 　

    ISSN： 2045-2322

  48. Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review. International-journal Peer-reviewed

    Takahiro Eitsuka, Kiyotaka Nakagawa, Shunji Kato, Junya Ito, Yurika Otoki, Soo Takasu, Naoki Shimizu, Takumi Takahashi, Teruo Miyazawa

    International journal of molecular sciences　19　(2)　2018/02/06

    DOI： 10.3390/ijms19020478 　

    ISSN： 1422-0067 1661-6596

  49. HPLC-MS/MS: A potential method to track the in vivo degradation of zein-based biomaterial. International-journal Peer-reviewed

    Hua-Jie Wang, Yue Zhang, Shunji Kato, Kiyotaka Nakagawa, Fumiko Kimura, Teruo Miyazawa, Jin-Ye Wang

    Journal of biomedical materials research. Part A　106　(2)　606-613　2018/02

    DOI： 10.1002/jbm.a.36252 　

    ISSN： 1549-3296

  50. Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. International-journal Peer-reviewed

    Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa

    Royal Society open science　5　(2)　171249-171249　2018/02

    DOI： 10.1098/rsos.171249 　

    ISSN： 2054-5703

  51. Determination of triacylglycerol oxidation mechanisms in canola oil using liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

    Shunji Kato, Naoki Shimizu, Yasuhiko Hanzawa, Yurika Otoki, Junya Ito, Fumiko Kimura, Susumu Takekoshi, Masayoshi Sakaino, Takashi Sano, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    NPJ science of food　2　(1)　1-1　2018

    DOI： 10.1038/s41538-017-0009-x 　

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    Triacylglycerol (TG), the main component of edible oil, is oxidized by thermal- or photo- oxidation to form TG hydroperoxide (TGOOH) as the primary oxidation product. Since TGOOH and its subsequent oxidation products cause not only the deterioration of oil quality but also various toxicities, preventing the oxidation of edible oils is essential. Therefore understanding oxidation mechanisms that cause the formation of TGOOH is necessary. Since isomeric information of lipid hydroperoxide provides insights about oil oxidation mechanisms, we focused on dioleoyl-(hydroperoxy octadecadienoyl)-TG (OO-HpODE-TG) isomers, which are the primary oxidation products of the most abundant TG molecular species (dioleoyl-linoleoyl-TG) in canola oil. To secure highly selective and sensitive analysis, authentic OO-HpODE-TG isomer references (i.e., hydroperoxide positional/geometrical isomers) were synthesized and analyzed with HPLC-MS/MS. With the use of the method, photo- or thermal- oxidized edible oils were analyzed. While dioleoyl-(10-hydroperoxy-8E,12Z-octadecadienoyl)-TG (OO-(10-HpODE)-TG) and dioleoyl-(12-hydroperoxy-9Z,13E-octadecadienoyl)-TG (OO-(12-HpODE)-TG) were characteristically detected in photo-oxidized oils, dioleoyl-(9-hydroperoxy-10E,12E-octadecadienoyl)-TG and dioleoyl-(13-hydroperoxy-9E,11E-octadecadienoyl)-TG were found to increase depending on temperature in thermal-oxidized oils. These results prove that our methods not only evaluate oil oxidation in levels that are unquantifiable with peroxide value, but also allows for the determination of oil oxidation mechanisms. From the analysis of marketed canola oils, photo-oxidized products (i.e., OO-(10-HpODE)-TG and OO-(12-HpODE)-TG) were characteristically accumulated compared to the oil analyzed immediately after production. The method described in this paper is valuable in the understanding of oil and food oxidation mechanisms, and may be applied to the development of preventive methods against food deterioration.

  52. Analysis of Lutein in Mugwort (Artemisia princeps Pamp.) Paste and Evaluation of Manufacturing Processes. Peer-reviewed

    Marina Komuro, Naoki Shimizu, Ryo Onuma, Yurika Otoki, Junya Ito, Shunji Kato, Ohki Higuchi, Keiichi Sudo, Seiichiro Suzuki, Teruo Miyazawa, Takahiro Eitsuka, Kiyotaka Nakagawa

    Journal of oleo science　66　(11)　1257-1262　2017/11/01

    DOI： 10.5650/jos.ess17117 　

    ISSN： 1345-8957

  53. A novel chiral stationary phase LC-MS/MS method to evaluate oxidation mechanisms of edible oils. International-journal Peer-reviewed

    Junya Ito, Naoki Shimizu, Eri Kobayashi, Yasuhiko Hanzawa, Yurika Otoki, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

    Scientific reports　7　(1)　10026-10026　2017/08/30

    DOI： 10.1038/s41598-017-10536-2 　

    ISSN： 2045-2322

  54. High-fat Diet Increases Phospholipid Peroxidation in the Liver of Mature Fischer 344 Rats. Peer-reviewed

    Saki Hayasaka, Fumiko Kimura, Shunji Kato, Naoki Shimizu, Junya Ito, Oki Higuchi, Katsuhiro Izumisawa, Teruo Miyazawa, Kiyotaka Nakagawa

    Journal of oleo science　66　(6)　607-614　2017/06/01

    DOI： 10.5650/jos.ess16225 　

    ISSN： 1345-8957

  55. Evaluation of the Mechanisms of Mayonnaise Phospholipid Oxidation. Peer-reviewed

    Shunji Kato, Tatsuya Iseki, Yasuhiko Hanzawa, Yurika Otoki, Junya Ito, Fumiko Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

    Journal of oleo science　66　(4)　369-374　2017/04/03

    DOI： 10.5650/jos.ess16187 　

    ISSN： 1345-8957

  56. Mass Spectrometric Discrimination of Squalene Monohydroperoxide Isomers. Peer-reviewed

    Naoki Shimizu, Hannah Bersabe, Junya Ito, Shunji Kato, Ryo Towada, Takahiro Eitsuka, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

    Journal of oleo science　66　(3)　227-234　2017/03/01

    DOI： 10.5650/jos.ess16159 　

    ISSN： 1345-8957

  57. Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

    Yurika Otoki, Shunji Kato, Fumiko Kimura, Katsutoshi Furukawa, Shinji Yamashita, Hiroyuki Arai, Teruo Miyazawa, Kiyotaka Nakagawa

    Journal of pharmaceutical and biomedical analysis　134　77-85　2017/02/05

    DOI： 10.1016/j.jpba.2016.11.019 　

    ISSN： 0731-7085

  58. Presence of orally administered rice bran oil γ-oryzanol in its intact form in mouse plasma. International-journal Peer-reviewed

    Eri Kobayashi, Junya Ito, Shunji Kato, Kazue Sawada, Midori Matsuki, Hiroyuki Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa

    Food & function　7　(12)　4816-4822　2016/12/07

    DOI： 10.1039/c6fo01552b 　

    ISSN： 2042-6496

    eISSN： 2042-650X

  59. A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. International-journal Peer-reviewed

    Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Toshiharu Nagai, Teruo Miyazawa

    Analytical and bioanalytical chemistry　408　(27)　7785-7793　2016/11

    DOI： 10.1007/s00216-016-9882-4 　

    ISSN： 1618-2642

    eISSN： 1618-2650

  60. Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect. International-journal Peer-reviewed

    Ayako Kure, Kiyotaka Nakagawa, Momoko Kondo, Shunji Kato, Fumiko Kimura, Akio Watanabe, Naoki Shoji, Sakiko Hatanaka, Tojiro Tsushida, Teruo Miyazawa

    Journal of agricultural and food chemistry　64　(21)　4246-54　2016/06/01

    DOI： 10.1021/acs.jafc.6b00964 　

    ISSN： 0021-8561

  61. The combination of maternal and offspring high-fat diets causes marked oxidative stress and development of metabolic syndrome in mouse offspring. International-journal Peer-reviewed

    Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

    Life sciences　151　70-75　2016/04/15

    DOI： 10.1016/j.lfs.2016.02.089 　

    ISSN： 0024-3205

  62. Accumulation of lipid hydroperoxide and cell senescence Peer-reviewed

    Shunji Kato, Kiyotaka Nakagawa, Teruo Miyazawa

    Journal of Lipid Nutrition　25　(1)　25-34　2016

    Publisher: Japan Society of Lipid Nutrition

    DOI： 10.4010/jln.25.25 　

    ISSN： 1343-4594

    eISSN： 1883-2237

  63. MS/MS and LC-MS/MS analysis of choline/ethanolamine plasmalogens via promotion of alkali metal adduct formation. International-journal Peer-reviewed

    Yurika Otoki, Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences　1004　85-92　2015/11/01

    DOI： 10.1016/j.jchromb.2015.09.012 　

    ISSN： 1570-0232

  64. Direct separation of the diastereomers of phosphatidylcholine hydroperoxide bearing 13-hydroperoxy-9Z,11E-octadecadienoic acid using chiral stationary phase high-performance liquid chromatography. International-journal Peer-reviewed

    Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Toshiharu Nagai, Teruo Miyazawa

    Journal of chromatography. A　1386　53-61　2015/03/20

    DOI： 10.1016/j.chroma.2015.01.080 　

    ISSN： 0021-9673

  65. Metabolism and cytotoxic effects of phosphatidylcholine hydroperoxide in human hepatoma HepG2 cells. International-journal Peer-reviewed

    Yuuri Suzuki, Kiyotaka Nakagawa, Shunji Kato, Naoto Tatewaki, Shunsuke Mizuochi, Junya Ito, Takahiro Eitsuka, Hiroshi Nishida, Teruo Miyazawa

    Biochemical and biophysical research communications　458　(4)　920-7　2015/03/20

    DOI： 10.1016/j.bbrc.2015.02.063 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  66. Liquid chromatography-tandem mass spectrometry determination of human plasma 1-palmitoyl-2-hydroperoxyoctadecadienoyl-phosphatidylcholine isomers via promotion of sodium adduct formation. International-journal Peer-reviewed

    Shunji Kato, Kiyotaka Nakagawa, Yuuri Suzuki, Akira Asai, Mototsugu Nagao, Kazuyuki Nagashima, Shinichi Oikawa, Teruo Miyazawa

    Analytical biochemistry　471　51-60　2015/02/15

    DOI： 10.1016/j.ab.2014.10.017 　

    ISSN： 0003-2697

  67. Tandem mass spectrometry analysis of linoleic and arachidonic acid hydroperoxides via promotion of alkali metal adduct formation. International-journal Peer-reviewed

    Junya Ito, Shunsuke Mizuochi, Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

    Analytical chemistry　87　(9)　4980-7　2015

    DOI： 10.1021/acs.analchem.5b00851 　

    ISSN： 0003-2700

  68. Determination of Phosphatidylcholine Hydroperoxide (PCOOH) as a Marker of Membrane Lipid Peroxidation. Peer-reviewed

    Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

    Journal of nutritional science and vitaminology　61 Suppl　S78-80-80　2015

    DOI： 10.3177/jnsv.61.S78 　

    ISSN： 0301-4800

  69. LC−MSIMS analysis of pyrroloquinoline quinone（PQQ） Peer-reviewed

    Atsumasa Ando, Mitsutaka Takeda, Shunji Kato, Fumiko Kimura, Kiyotaka Nakagawa, Masahiko Nakano, Teruo Miyazawa

    88　(12)　601-609　2014

  70. Preparation of 13 or 9-hydroperoxy-9Z,11E (9E,11E) or 10E,12Z (10E,12E)-octadecadienoic phosphatidylcholine hydroperoxide. Peer-reviewed

    Shunji Kato, Kiyotaka Nakagawa, Yuuri Suzuki, Koichiro Suzuki, Shunsuke Mizuochi, Teruo Miyazawa

    Journal of oleo science　63　(5)　431-7　2014

    DOI： 10.5650/jos.ess13225 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  71. Oxidative stress during development of alcoholic fatty liver: therapeutic potential of cacao polyphenol. International-journal Peer-reviewed

    Koichiro Suzuki, Kiyotaka Nakagawa, Taiki Miyazawa, Shunji Kato, Fumiko Kimura, Masanori Kamei, Teruo Miyazawa

    Bioscience, biotechnology, and biochemistry　77　(8)　1792-4　2013

    DOI： 10.1271/bbb.130380 　

    ISSN： 0916-8451

    eISSN： 1347-6947

  72. Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects. Peer-reviewed

    Taiki Miyazawa, Kiyotaka Nakagawa, Hideo Takekoshi, Ohki Higuchi, Shunji Kato, Momoko Kondo, Fumiko Kimura, Teruo Miyazawa

    Journal of oleo science　62　(11)　873-81　2013

    DOI： 10.5650/jos.62.873 　

    ISSN： 1345-8957

    eISSN： 1347-3352

  73. Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures. International-journal Peer-reviewed

    Kiyotaka Nakagawa, Akira Shibata, Tatsuya Saito, Phumon Sookwong, Shunji Kato, Tsuyoshi Tsuduki, Kiminori Matsubara, Teruo Miyazawa

    Biochimica et biophysica acta　1810　(12)　1205-11　2011/12

    DOI： 10.1016/j.bbagen.2011.08.018 　

    ISSN： 0006-3002

    More details Close

    BACKGROUND: Phosphatidylcholine hydroperoxide (PCOOH) is a primary oxidation product of PC, and is markedly accumulated in blood plasma and arterial walls in atherosclerotic animals and humans. The role of PCOOH in the induction of angiogenesis is unknown. METHODS: In this study, we investigated whether PCOOH stimulated angiogenic responses (e.g., vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and tube formation, and angiogenesis-related gene/protein expression) in human umbilical vein endothelial cells (HUVEC) and in an ex vivo rat aorta model. RESULTS: VEGF induced proliferation, migration, and tube formation of HUVEC, and these angiogenic responses were all enhanced by PCOOH but not by native (nonoxidized) PC. The angiogenic effects of PCOOH are considered to be mediated via generation of reactive oxygen species and activation of both PI3K/AKT and MAPK pathways. The angiogenic activities of PCOOH were also confirmed by the rat aortic ring assay. CONCLUSIONS: These results indicate that PCOOH can elicit several angiogenic responses. GENERAL SIGNIFICANCE: The present study implies an important role of PCOOH in atherosclerosis progression and plaque instability.

  74. Tocotrienol distribution in foods: estimation of daily tocotrienol intake of Japanese population. International-journal Peer-reviewed

    Phumon Sookwong, Kiyotaka Nakagawa, Yasuhiro Yamaguchi, Taiki Miyazawa, Shunji Kato, Fumiko Kimura, Teruo Miyazawa

    Journal of agricultural and food chemistry　58　(6)　3350-5　2010/03/24

    DOI： 10.1021/jf903663k 　

    ISSN： 0021-8561

    More details Close

    Tocotrienol (T3) is an unsaturated form of natural vitamin E that has been focused on because of its potential health benefits (i.e., antioxidative, antihypercholesterolemic, and antiangiogenic effects). The presence of T3 in some plant sources (e.g., rice bran and palm oil) is known, but its distribution in other edible sources and its daily intake remain unclear. In this study, we aimed at clarifying the distribution of T3 in various food sources and estimating the daily T3 intake of Japanese population. T3 contents of 242 food items and 64 meal items were measured by using normal-phase HPLC with fluorescence detection. As for the results, T3 contents were nondetectable to 12 mg T3/kg wet wt of food items, and nondetectable to 1.3 mg T3/item of processed (cooked) meal. Accordingly, the daily intake of T3 was estimated as 1.9-2.1 mg T3/day/person. The estimated daily intake of T3 appears rather low compared with the intake of tocopherol (8-10 mg/day/person as reported in the Japanese National Nutrition Survey), and additional T3 is important for its therapeutic aspects.

Show all ︎Show first 5

Misc. 197

  1. 涙液に含まれる脂質とその光酸化に関する研究

    佐藤遥佳, 楠本惟吹, 上遠野佑紀, 加藤俊治, 檜森紀子, 中澤徹, 仲川清隆

    脂質生化学研究　68　2026

    ISSN： 0285-1520

  2. 酸化リン脂質受容GPCRの同定と機能解析

    小櫻英翔, 上野亮哉, 岩本竜弥, 加藤俊治, 仲川清隆, MIRINTHORN Jutanom, 森本和志, 山田健一

    日本酸化ストレス学会学術集会プログラム・抄録集　78th　2025

  3. オーファンGPCRを活性化する酸化リン脂質の構造解析

    岩本竜弥, 小櫻英翔, 上野亮哉, 加藤俊治, 仲川清隆, JUTANOM Mirinthorn, 森本和志, 山田健一

    日本酸化ストレス学会学術集会プログラム・抄録集　78th　2025

  4. LC-MS/MS-Driven Identification of Oxidized Phospholipid-Responsive GPCR and Discovery of Their Ligands

    小櫻英翔, 岩本竜弥, 加藤俊治, 仲川清隆, 森本和志, 阿部真紗美, PAKAWIT Lerksaipheng, MIRINTHORN Jutanom, 山田健一

    バイオメディカル分析科学シンポジウム講演要旨集　37th　2025

    ISSN： 1347-2364

  5. 過酸化脂質(トリアシルグリセロールヒドロペルオキシド)の吸収代謝の評価

    俵谷理瑚, 加藤俊治, 吉永和明, 仲川清隆

    脂質栄養学　34　(2)　2025

    ISSN： 1343-4594

  6. LC-MS/MSを用いたトリアシルグリセロールヒドロペルオキシドの吸収代謝の評価

    加藤俊治, 俵谷理瑚, 吉永和明, 仲川清隆

    脂質生化学研究　67　2025

    ISSN： 0285-1520

  7. 生理活性を発揮する新規酸化リン脂質分子の探索

    上野亮哉, 高橋政友, 和泉自泰, 馬場健史, 加藤俊治, 仲川清隆, MIRINTHORN Jutanom, 森本和志, 山田健一

    脂質生化学研究　67　2025

    ISSN： 0285-1520

  8. 酸化リン脂質受容GPCRの同定と機能解析

    小櫻英翔, 上野亮哉, 岩本竜弥, 加藤俊治, 仲川清隆, MIRINTHORN Jutanom, 森本和志, 山田健一

    日本薬学会九州山口支部大会講演要旨集(CD-ROM)　41st　2024

  9. ZenoTOF7600システムを用いたトリアシルグリセロールヒドロペルオキシドの吸収代謝の評価

    俵谷理瑚, 高橋巧, 加藤俊治, 伊藤隼哉, 乙木百合香, 吉永和明, 仲川清隆

    日本農芸化学会東北支部大会プログラム・講演要旨集　159th (Web)　2024

  10. トコフェロールが脂質光酸化に与える影響:波長別の光を用いた検討

    加藤俊治, 兪佳娜, 乙木百合香, 仲川清隆

    ビタミン　97　(4)　2023

    ISSN： 0006-386X

  11. 植物油酸化原因を迅速に見極める近赤外分光分析法の構築

    乙木百合香, 加藤俊治, 石川大太郎, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　77th　2023

  12. Relationship between water activity and lipid oxidation: Involvement of Maillard reaction or not

    重松孝暢, 高田朋之, 乙木百合香, 伊藤隼哉, 加藤俊治, 横山光子, 松本哲哉, 江藤淳, 仲川清隆

    日本メイラード学会年会プログラム・抄録集　33rd　2023

  13. 食べた過酸化脂質はどのように消化・吸収されるのか?(ラットを用いた評価)

    仲川清隆, 高橋巧, 加藤俊治, 吉永和明, 桐明絢, 後藤直宏, 池田郁男

    日本酸化ストレス学会学術集会プログラム・抄録集　76th　2023

  14. Unique Structural Information Obtained from Metal Adducts on Mass Spectrometry

    加藤俊治, 乙木百合香, 仲川清隆

    オレオサイエンス　22　(6)　2022

    ISSN： 1345-8949

  15. 食用油の長期保存におけるこめ油の酸化防止効果

    小石翔太, 小石翔太, 奥田安美, 河野龍之進, 中島成生, HALIDA Rahmania, 乙木百合香, 加藤俊治, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　76th　2022

  16. 質量分析を用いた飽和脂肪酸の酸化経路の解明

    加藤俊治, 乙木百合香, 青柳寛司, 青柳寛司, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　76th　2022

  17. トリアシルグリセロールヒドロペルオキシドの吸収代謝の新仮説検証~疾病との関連解明に向けて~

    高橋巧, 加藤俊治, 伊藤隼哉, 吉永和明, 桐明絢, 後藤直宏, 仲川清隆

    脂質栄養学　31　(2)　2022

    ISSN： 1343-4594

  18. Elucidation of absorption and metabolism of triacylglycerol hydroperoxide by stable isotope labeling

    高橋巧, 加藤俊治, 伊藤隼哉, 吉永和明, 桐明絢, 後藤直宏, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2022　2022

    ISSN： 2186-7976

  19. Alternation of arachidonic acid and docosahexaenoic acid epoxides bound to neutral lipids following acute hypercapnia/ischemia in rat brain

    乙木百合香, 乙木百合香, 加藤俊治, 仲川清隆, AMEER Taha

    日本農芸化学会大会講演要旨集(Web)　2021　2021

    ISSN： 2186-7976

  20. Determination of acrolein generation pathways from linoleic acid and linolenic acid: Increase in acrolein generation by photo irradiation

    加藤俊治, 清水直紀, 乙木百合香, 伊藤隼哉, 境野眞善, 境野眞善, 佐野貴士, 竹内茂雄, 今義潤, 今義潤, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2021　2021

    ISSN： 2186-7976

  21. 近赤外分光分析から読み解く植物油酸化原因特定の研究

    乙木百合香, 加藤俊治, 石川大太郎, 仲川清隆

    日本食品科学工学会大会講演集　68th　2021

  22. 脂質の光酸化に影響する波長の評価

    加藤俊治, 乙木百合香, 仲川清隆

    日本食品科学工学会大会講演集　68th　2021

  23. Analysis of plasmalogens and related phospholipids in the brain of Alzheimer’s disease at the early stages

    野間口早紀, 乙木百合香, 仲川清隆, 加藤俊治, 伊藤隼哉, 高須蒼生, 板谷麻由子, 清水直紀, 宮崎瑠璃子, 中務絵梨子, 山田皓輝

    日本農芸化学会大会講演要旨集(Web)　2021　2021

    ISSN： 2186-7976

  24. オリーブオイル酸化機構(熱・光)の数値化と光酸化に影響する波長の解析

    加藤俊治, 高橋隼登, 乙木百合香, 伊藤隼哉, 境野眞善, 境野眞善, 佐野貴士, 竹内茂雄, 今義潤, 今義潤, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　75th　2021

  25. グルコシルセラミドの酸化修飾とCaco-2培養細胞系における抗炎症作用

    JUTANOM Mirinthorn, 加藤俊治, 乙木百合香, 伊藤隼哉, 山下慎司, 木下幹朗, 永塚貴弘, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　75th　2021

  26. Determination of vegetable oil oxidation cause by NIR

    乙木百合香, 加藤俊治, 石川大太郎, 尾崎幸洋, 仲川清隆

    近赤外フォーラム講演要旨集　37th (CD-ROM)　2021

  27. Evaluation of enzymatic lipid peroxidation using Ion mobility mass spectrometry

    伊藤隼哉, 清水直紀, 加藤俊治, 花田篤志, 前川正充, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2021　2021

    ISSN： 2186-7976

  28. フラボノイド(ルテオリン)の吸収代謝の評価 : 機能性in vitro試験に求められること—Evaluating the absorption and metabolism of flavonoids (luteolin) : what is required for in vitro tests—特集 機能性表示食品とアンチエイジング

    清水 直紀, 仲川 清隆, 加藤 俊治

    Anti-aging medicine / 日本抗加齢医学会 [編]　16　(4)　484-489　2020/08

    Publisher: 大阪 : メディカルレビュー社

    ISSN： 1880-1579

  29. 研究室紹介 Invited

    加藤俊治, 仲川清隆

    ビタミン　94　33-37　2020/02

  30. アルツハイマー病の脳および血中プラズマローゲンの分子種解析

    乙木百合香, 乙木百合香, 加藤俊治, 仲川清隆, TAHA Ameer Y.

    脂質生化学研究　62　2020

    ISSN： 0285-1520

  31. LC-MS/MSによるピロロキノリンキノン(PQQ)とPQQアミノ酸付加体の測定:食品分布の解明に向けて

    加藤主税, 加藤俊治, 前田鋭, 伊藤隼哉, 乙木百合香, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　74th　2020

  32. Oxidative modification of glucosylceramide and its anti-inflammatory effect in differentiated Caco-2 cells

    JUTANOM Mirinthorn, 乙木百合香, 加藤俊治, 伊藤隼哉, 山下慎司, 木下幹朗, 仲川清隆

    日本栄養・食糧学会東北支部大会およびシンポジウム講演要旨集　54th (CD-ROM)　2020

  33. Amount of lipid glycation products absorbed into the body of rats

    伊藤隼哉, 梅津直生, 乙木百合香, 加藤俊治, 永塚貴弘, 仲川清隆

    日本メイラード学会学術集会プログラム・抄録集　30th (CD-ROM)　2020

  34. 脂質メイラード産物の体内吸収の評価:LC-MS/MSを用いた解析を通して

    伊藤隼哉, 梅津直生, 乙木百合香, 加藤俊治, 永塚貴弘, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　74th　2020

  35. Evaluating the absorption and metabolism of flavonoids (luteolin): what is required for in vitro tests

    仲川清隆, 清水直紀, 加藤俊治

    アンチ・エイジング医学　16　(4)　2020

    ISSN： 1880-1579

  36. 紫外線を浴びたら何を食べる？ 酸化ストレスと抗酸化食品 Invited Peer-reviewed

    加藤俊治, 仲川清隆

    現代科学　1　34-37　2020/01

  37. 主要リポタンパクに含まれるコレステロールエステルおよびホスファチジルコリンのヒドロペルオキシド異性体解析

    大須賀 佑輔, 加藤 俊治, 伊藤 隼哉, 永塚 貴弘, 仲川 清隆

    脂質生化学研究　61　218-220　2019/06

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  38. 質量分析によるトリアシルグリセロールヒドロペルオキシド分析法の構築

    加藤 俊治, 竹腰 進, 仲川 清隆

    脂質生化学研究　61　221-223　2019/06

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  39. サメ肝油中スクアレンの酸化評価とα-トコフェロールによる酸化抑制

    清水 直紀, 伊藤 隼哉, 加藤 俊治, 永塚 貴弘, 齋藤 哲男, 西田 浩志, 仲川 清隆

    ビタミン　93　(4)　203-203　2019/04

    Publisher: (公社)日本ビタミン学会

    ISSN： 0006-386X

  40. カチオン-π電子相互作用に基づく脂質ヒドロペルオキシドの異性体解析

    加藤俊治, 乙木百合香, 伊藤隼哉, 永塚貴弘, 仲川清隆

    日本油化学会年会講演要旨集　58th　2019

    ISSN： 1348-6764

  41. 食用油, 保存に気をつけていますか？ -油脂酸化の化学 Peer-reviewed

    加藤俊治, 仲川清隆

    化学　74　30-34　2019/01

  42. 粉乳に含まれる脂質糖化産物の解析と腸管吸収の評価

    梅津直生, 小舘愛, 伊藤隼哉, 乙木百合香, 加藤俊治, 加藤俊治, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本メイラード学会学術集会プログラム・抄録集　28th　16　2018/09/30

  43. 多様なトリアシルグリセロール分子種から成る油脂の初期酸化メカニズム解析

    加藤俊治, 加藤俊治, 伊藤隼哉, 境野眞善, 佐野貴士, 竹腰進, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本油化学会年会講演要旨集　57th　139　2018/09/04

    ISSN： 1348-6764

  44. 多発性硬化症者の脳中プラズマローゲン分子種解析

    乙木百合香, 乙木百合香, 加藤俊治, 加藤俊治, 山下慎司, 宮澤陽夫, 宮澤陽夫, 仲川清隆, TAHA Ameer Y

    日本油化学会年会講演要旨集　57th　104　2018/09/04

    ISSN： 1348-6764

  45. 質量分析を用いたオリーブ油の酸化メカニズム推定

    高橋隼登, 加藤俊治, 加藤俊治, 伊藤隼哉, 境野眞善, 佐野貴士, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本食品科学工学会大会講演集　65th　136　2018/08/22

  46. 油脂の初期酸化とその評価法

    加藤俊治

    日本食品科学工学会大会講演集　65th　45　2018/08/22

  47. スクアレンの酸化機構と抗酸化物質によるスクアレン酸化抑制効果の評価

    清水直紀, 伊藤隼哉, 加藤俊治, 加藤俊治, 後藤昌史, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　60　231-233　2018/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  48. 過酸化リン脂質の立体異性体解析に向けたLC‐IMS‐MS/MS法の開発

    伊藤隼哉, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　60　228-230　2018/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  49. 質量分析による生体脂質過酸化機構の解明

    加藤俊治, 加藤俊治, 北谷佳那恵, 宮澤陽夫, 宮澤陽夫, 仲川清隆, 竹腰進

    日本酸化ストレス学会学術集会プログラム・抄録集　71st　129　2018/04/19

  50. ホスファチジルコリンヒドロペルオキシド(PCOOH)の代謝機構とPCOOHが惹起する細胞死へのビタミンEの影響

    仲川清隆, 勝野真美, 伊藤隼哉, 加藤俊治, 永塚貴弘, 今井浩孝, 宮澤陽夫, 宮澤陽夫

    ビタミン　92　(4)　204-204　2018/04

    Publisher: (公社)日本ビタミン学会

    ISSN： 0006-386X

  51. マウスにおけるこめ油γ‐オリザノールの体内分布:生理作用発現との関係性

    伊藤隼哉, 小林エリ, 加藤俊治, 澤田一恵, 橋本博之, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　72回　200-200　2018/04

    Publisher: (公社)日本栄養・食糧学会

  52. 油脂に含まれるトコフェロール酸化物,とくにトコフェロールヒドロペルオキシドの解析

    丹野玲菜, 加藤俊治, 伊藤隼哉, 小倉由資, 永塚貴弘, 桑原重文, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　72回　296-296　2018/04

    Publisher: (公社)日本栄養・食糧学会

  53. イオンモビリティーを活用した過酸化リン脂質のLC‐MS/MS立体異性体解析法

    伊藤隼哉, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2018　ROMBUNNO.2B06p02 (WEB ONLY)　2018/03/05

    ISSN： 2186-7976

  54. ヒト皮脂中のスクアレン酸化機構の解析および抗酸化物質によるスクアレン酸化抑制効果の評価

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2018　ROMBUNNO.2B06p01 (WEB ONLY)　2018/03/05

    ISSN： 2186-7976

  55. ラット胸管リンパカニュレーション試験によるγ‐オリザノールの腸管吸収の評価

    小林エリ, 伊藤隼哉, 澤田一恵, 橋本博之, 加藤俊治, 永塚貴弘, 池田郁男, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2018　ROMBUNNO.2B04a12 (WEB ONLY)　2018/03/05

    ISSN： 2186-7976

  56. Naイオンを用いたDAGOOH異性体の分析法

    加藤俊治, 仲川清隆, 竹腰進

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　26th　8　2018

  57. ホスファチジルコリンヒドロペルオキシド(PCOOH)の代謝機構とPCOOHが惹起する細胞死との関係性

    仲川清隆, 内野正, 伊藤隼哉, 加藤俊治, 永塚貴弘, 今井浩孝, 竹腰進, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　26th　9　2018

  58. 粉乳に含まれる脂質糖化産物の分析法の構築と腸管吸収の評価

    伊藤隼哉, 小舘愛, 梅津直生, 乙木百合香, 加藤俊治, 加藤俊治, 池田郁男, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本メイラード学会学術集会プログラム・抄録集　27th　30　2017/11/18

  59. プラズマローゲン分解物や合成中間体の分析

    乙木百合香, 加藤俊治, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会東北支部大会プログラム・講演要旨集　152nd　36　2017/11/01

  60. 質量分析を用いた高精度な油脂酸化評価法の開発

    加藤俊治, 加藤俊治, 伊藤隼哉, 佐野貴士, 境野眞善, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本食品科学工学会大会講演集　64th　92　2017/08/28

  61. ビタミンE酸化物の検出と抗酸化機序の評価:食用油脂への応用

    丹野玲菜, 加藤俊治, 加藤俊治, 清水直紀, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本食品科学工学会大会講演集　64th　117　2017/08/28

  62. New insights into the absorption and metabolism of γ-oryzanol

    Kobayashi, E, Ito, J, Shimizu, N, Kato, S, Sawada, K, Matsuki, M, Hashimoto, H, Ikeda, I, Miyazawa, T, Nakagawa, K

    The 4th International Conference on Rice Bran Oil 2017 (ICRBO 2017) Proceedings　27-33　2017/08

  63. 過酸化リン脂質(PCOOH)が誘導する細胞死メカニズムの検証

    伊藤隼哉, 三上優依, 勝野真美, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　59　37-38　2017/06

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  64. 過酸化脂質の異性体解析を通じた皮脂の酸化機構の解明

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　59　253-254　2017/06

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  65. Utilizing phytonutrients for public health and establishing Global Phytonutrient Society (GPS)

    Harunobu Amagase, Teruo Miyazawa, Kiyotaka Nakagawa, Shunji Kato

    FASEB JOURNAL　31　2017/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  66. 酵素法とLC‐MS/MS法によるピロロキノリンキノン測定:天然資源の探索に向けて

    河合笑子, 加藤主税, 乙木百合香, 加藤俊治, 三毛門毅, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    ビタミン　91　(4)　258-258　2017/04

    Publisher: (公社)日本ビタミン学会

    ISSN： 0006-386X

  67. ビタミンEが過酸化脂質により誘導されるフェロトーシスに与える影響

    伊藤隼哉, 三上優依, 勝野真美, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    ビタミン　91　(4)　265-265　2017/04

    Publisher: (公社)日本ビタミン学会

    ISSN： 0006-386X

  68. HPLC‐MS/MSを用いたリノール酸エステルヒドロペルオキシド異性体の分析法の構築

    小室麻里菜, 伊藤隼哉, 加藤俊治, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　71回　367-367　2017/04

    Publisher: (公社)日本栄養・食糧学会

  69. ヒト皮脂中のスクアレンヒドロペルオキシド異性体の分析

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　71回　265-265　2017/04

    Publisher: (公社)日本栄養・食糧学会

  70. マウス生体内におけるγ‐オリザノールの存在形態の評価:γ‐オリザノールの吸収代謝解明に向けて

    小林エリ, 伊藤隼哉, 加藤俊治, 澤田一恵, 松木翠, 橋本博之, 池田郁男, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　71回　256-256　2017/04

    Publisher: (公社)日本栄養・食糧学会

  71. リノール酸ヒドロペルオキシドとフェロトーシスの関係解明:異性体の違いに着目して

    伊藤隼哉, 三上優依, 勝野真美, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会大会講演要旨集　71回　265-265　2017/04

    Publisher: (公社)日本栄養・食糧学会

  72. プラズマローゲン分解物や関連化合物の定量法確立と臨床サンプル測定

    乙木百合香, 加藤俊治, MARIE Hennebelle, AMEER Taha, WALTER Swardfager, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2017　ROMBUNNO.2A07p01 (WEB ONLY)　2017/03/05

    ISSN： 2186-7976

  73. エタノールアミン型プラズマローゲンの吸収評価:とくにコリン型への変換について

    上吉原怜奈, 乙木百合香, 伊藤隼哉, 加藤俊治, 山下慎司, 池田郁男, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2017　ROMBUNNO.2A07p02 (WEB ONLY)　2017/03/05

    ISSN： 2186-7976

  74. ルテオリンの吸収動態と生理作用の評価

    早坂夏実, 呉綾子, 加藤俊治, 毛利哲, 津志田藤二郎, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2017　ROMBUNNO.2A07p03 (WEB ONLY)　2017/03/05

    ISSN： 2186-7976

  75. LC‐MS/MSによるリポタンパク脂質の酸化メカニズム解析

    加藤俊治, 伊藤隼哉, 清水直紀, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2017　ROMBUNNO.2B09a08 (WEB ONLY)　2017/03/05

    ISSN： 2186-7976

  76. 質量分析を用いた粉乳に含まれる脂質糖化産物の分析法の構築

    伊藤隼哉, 小舘愛, 乙木百合香, 加藤俊治, 池田郁男, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会大会講演要旨集(Web)　2017　ROMBUNNO.3A03a05 (WEB ONLY)　2017/03/05

    ISSN： 2186-7976

  77. アミノ酸によるグリケーション抑制の網羅的解析

    佐藤 由佳, 伊藤 芳明, 加藤 俊治, 仲川 清隆, 長澤 孝志

    アミノ酸研究　10　(1)　80-80　2017/03

    Publisher: 日本アミノ酸学会

    ISSN： 1882-5001

  78. EVALUATION OF THE MECHANISMS OF MAYONNAISE PHOSPHOLIPID PEROXIDATION

    Kiyotaka Nakagawa, Shunji Kato, Yurika Otoki, Junya Ito, Teruo Miyazawa

    ANNALS OF NUTRITION AND METABOLISM　71　1299-1300　2017

    ISSN： 0250-6807

    eISSN： 1421-9697

  79. ACCURATE QUANTITATION OF PLASMALOGEN AND RELATED PHOSPHOLIPIDS BY USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY

    Yurika Otoki, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa

    ANNALS OF NUTRITION AND METABOLISM　71　383-383　2017

    ISSN： 0250-6807

    eISSN： 1421-9697

  80. リノール酸過酸化物を指標とした食品の酸化機構の評価

    伊藤隼哉, 塩見大樹, 加藤俊治, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会東北支部大会およびシンポジウム講演要旨集　51st　26　2017

  81. アルカリ金属を使用した脂質過酸化物の解析

    加藤俊治, 加藤俊治, 清水直紀, 乙木百合香, 伊藤隼哉, 北谷佳那恵, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 竹腰進, 仲川清隆

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　25th　7　2017

  82. LC‐MS/MSを用いたヒト皮脂中のスクアレン酸化機構の解析

    清水直紀, 伊藤隼哉, 加藤俊治, 加藤俊治, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　25th　6　2017

  83. 質量分析における精確な定量~生体過酸化脂質の定量を例として~

    加藤俊治

    オレオサイエンス　16　(10)　493‐496-496　2016/10/01

    Publisher: 日本油化学会

    ISSN： 1345-8949

  84. アミノ酸によるグリケーション抑制の網羅的解析

    佐藤由佳, 伊藤芳明, 加藤俊治, 仲川清隆, 長澤孝志

    日本アミノ酸学会学術大会講演要旨集　10th　42　2016/09/11

  85. ルテオリンの吸収代謝と代謝物の生理作用の評価

    仲川清隆, 呉綾子, 近藤桃子, 加藤俊治, 木村ふみ子, 渡辺章夫, 渡辺章夫, 庄子真樹, 畑中咲子, 津志田藤二郎, 宮澤陽夫

    日本油化学会年会講演要旨集　55th　186　2016/09/07

    ISSN： 1348-6764

  86. こめ油γ‐オリザノールの脂肪蓄積抑制作用および吸収代謝評価

    小林エリ, 伊藤隼哉, 加藤俊治, 松木翠, 澤田一恵, 橋本博之, 木村ふみ子, 宮澤陽夫, 仲川清隆

    日本油化学会年会講演要旨集　55th　190　2016/09/07

    ISSN： 1348-6764

  87. 血漿プラズマローゲン定量法の確立と臨床サンプル測定への応用

    乙木百合香, 乙木百合香, 加藤俊治, 古川勝敏, 荒井啓行, 木村ふみ子, SWARDFAGER Walter, HENNEBELLE Marie, TAHA Ameer, 宮澤陽夫, 仲川清隆

    日本油化学会年会講演要旨集　55th　218　2016/09/07

    ISSN： 1348-6764

  88. こめ油中のγ‐オリザノールの分析とマウスへの単回投与試験による血中分析

    澤田一恵, 松木翠, 中上拓也, 橋本博之, 小林エリ, 加藤俊治, 伊藤隼哉, 宮澤陽夫, 仲川清隆

    日本油化学会年会講演要旨集　55th　191　2016/09/07

    ISSN： 1348-6764

  89. キラルHPLC‐MS/MSを用いたリノール酸ヒドロペルオキシド異性体解析による食用油脂等の食品の脂質過酸化機構の評価

    伊藤隼哉, 加藤俊治, 塩見大樹, 宮澤陽夫, 仲川清隆

    日本油化学会年会講演要旨集　55th　219　2016/09/07

    ISSN： 1348-6764

  90. LC‐MS/MSを用いたヒトリポタンパク酸化機構の解明

    加藤俊治, 伊藤隼哉, 清水直紀, 浅井明, 長尾元嗣, 杉原仁, 及川眞一, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本生化学会大会(Web)　89回　[1P-076]　2016/09

    Publisher: (公社)日本生化学会

  91. 生体膜リン脂質過酸化物はフェロトーシスを誘導する

    伊藤隼哉, 三上優依, 勝野真美, 加藤俊治, 内野正, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本生化学会大会(Web)　89回　[3P-085]　2016/09

    Publisher: (公社)日本生化学会

  92. 酵素法とLC‐MS/MSによるピロロキノリンキノンの測定

    仲川清隆, 加藤主税, 河合笑子, 加藤俊治, 三毛門毅, 宮澤陽夫, 宮澤陽夫

    日本食品科学工学会大会講演集　63rd　107　2016/08/25

  93. 質量分析を用いた食用油脂酸化の新規評価法の構築

    加藤俊治, 伊藤隼哉, 丹野玲菜, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本食品科学工学会大会講演集　63rd　148　2016/08/25

  94. ナトリウムイオンの付加を利用した糖化脂質の新しいLC‐MS/MS分析

    仲川清隆, 小舘愛, 乙木百合香, 伊藤隼哉, 加藤俊治, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    ビタミン　90　(7)　359-360　2016/07

    Publisher: (公社)日本ビタミン学会

    DOI： 10.20632/vso.90.7_359_359 　

    ISSN： 0006-386X

  95. ヒト肝癌細胞HepG2細胞におけるホスファチジルコリンヒドロペルオキシドの代謝と毒性

    鈴木優里, 仲川清隆, 加藤俊治, 舘脇直人, 水落俊介, 伊藤隼哉, 永塚貴弘, 西田浩志, 宮澤陽夫

    ビタミン　90　(5)　274-280　2016/05

    Publisher: 日本ビタミン学会

    ISSN： 0006-386X

  96. 過酸化脂質異性体定量による酸化ストレス発生機序の解明―肥満マウスへの応用―

    加藤俊治, 佐藤洋介, 伊藤隼哉, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　58　110-112　2016/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  97. MS/MS,HPLC‐MS/MS,キラルHPLC‐MS/MSを活用した脂質過酸化機構の評価

    伊藤隼哉, 仲川清隆, 加藤俊治, 宮澤陽夫

    オレオサイエンス　16　(5)　233-242　2016/05

    Publisher: (公社)日本油化学会

    ISSN： 1345-8949

  98. ヒト肝臓癌細胞HepG2におけるホスファチジルコリンヒドロペルオキシド(PCOOH)の代謝と生理活性の評価

    伊藤隼哉, 三上優依, 加藤俊治, 内野正, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    脂質生化学研究　58　173-174　2016/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  99. 高脂肪食給与がF344ラット肝臓過酸化リン脂質(PCOOH)へ及ぼす影響

    早坂咲, 加藤俊治, 木村ふみ子, 仲川清隆, 泉澤勝弘, 宮澤陽夫, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　70th　165　2016/04/25

  100. LC-MS/MS evaluation about how lipoprotein lipids are oxidized in vivo

    Shunji Kato, Kiyotaka Nakagawa, Jyunya Ito, Yurika Otoki, Akira Asai, Mototsugu Nagao, Hitoshi Sugihara, Shinichi Oikawa, Teruo Miyazawa

    FASEB JOURNAL　30　2016/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  101. Accurate Quantification of Choline and Ethanolamine Plasmalogen Molecular Species by Liquid Chromatography coupled with Tandem Mass Spectrometry

    Yurika Otoki, Shunji Kato, Fumiko Kimura, Katshutoshi Furukawa, Hiroyuki Arai, Kiyotaka Nakagawa, Teruo Miyazawa

    FASEB JOURNAL　30　2016/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  102. Accurate Quantification of Choline and Ethanolamine Plasmalogen Molecular Species by Liquid Chromatography coupled with Tandem Mass Spectrometry

    Yurika Otoki, Shunji Kato, Fumiko Kimura, Katshutoshi Furukawa, Hiroyuki Arai, Kiyotaka Nakagawa, Teruo Miyazawa

    FASEB JOURNAL　30　2016/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  103. Accurate Quantification of Choline and Ethanolamine Plasmalogen Molecular Species by Liquid Chromatography coupled with Tandem Mass Spectrometry

    Yurika Otoki, Shunji Kato, Fumiko Kimura, Katshutoshi Furukawa, Hiroyuki Arai, Kiyotaka Nakagawa, Teruo Miyazawa

    FASEB JOURNAL　30　2016/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  104. 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係 新規選抜交配モデルマウスの解析から

    浅井 明, 長尾 元嗣, 川原 百代, 加藤 俊治, 宮澤 陽夫, 杉原 仁, 及川 眞一

    糖尿病　59　(Suppl.1)　S-148　2016/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  105. 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係 新規選抜交配モデルマウスの解析から

    浅井 明, 長尾 元嗣, 川原 百代, 加藤 俊治, 宮澤 陽夫, 杉原 仁, 及川 眞一

    糖尿病　59　(Suppl.1)　S-148　2016/04

    Publisher: (一社)日本糖尿病学会

    ISSN： 0021-437X

  106. 生体膜リン脂質過酸化物に着目した肥満における生体内酸化ストレスの評価

    伊藤隼哉, 佐藤洋介, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　70回　304-304　2016/04

    Publisher: (公社)日本栄養・食糧学会

  107. 粉乳に特徴的に含まれる脂質糖化産物の定量的考察

    小舘愛, 仲川清隆, 乙木百合香, 伊藤隼哉, 加藤俊治, 水落俊介, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　70回　239-239　2016/04

    Publisher: (公社)日本栄養・食糧学会

  108. LC‐MS/MSによる脂肪酸ヒドロペルオキシドの新規異性体解析法の構築

    伊藤隼哉, 水落俊介, 加藤俊治, 仲川清隆, 宮澤陽夫, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2016　2E005 (WEB ONLY)　2016/03/05

    ISSN： 2186-7976

  109. リン脂質ヒドロペルオキシド(PCOOH)光学異性体のLC‐MS/MS分析

    宮澤陽夫, 宮澤陽夫, 伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治

    ビタミン　90　(2)　87-89　2016/02

    Publisher: (公社)日本ビタミン学会

    DOI： 10.20632/vso.90.2_87 　

    ISSN： 0006-386X

  110. 3．ナトリウムイオンの付加を利用した糖化脂（第349 回会議研究発表要旨、脂溶性ビタミン総合研究委員会）

    仲川 清隆, 小舘 愛, 乙木 百合香, 伊藤 隼哉, 加藤 俊治, 木村 ふみ子, 宮澤 陽夫

    ビタミン　90　(7)　359-360　2016

    Publisher: 公益社団法人 日本ビタミン学会

    ISSN： 0006-386X

  111. 血漿プラズマローゲン定量法の確立と臨床サンプル測定への応用

    乙木百合香, 乙木百合香, 加藤俊治, TAHA AY, HENEVELLE M, SWARDFAGER W, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会東北支部大会プログラム・講演要旨集　151st　39　2016

  112. 粉乳に含まれる脂質糖化産物の分析法の構築

    小舘愛, 乙木百合香, 伊藤隼哉, 加藤俊治, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本農芸化学会東北支部大会プログラム・講演要旨集　151st　38　2016

  113. スクアレンヒドロペルオキシド異性体の高選択的な分析法の構築

    清水直紀, BERSABE Hannah, 伊藤隼哉, 加藤俊治, 十和田諒, 桑原重文, 永塚貴弘, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本栄養・食糧学会東北支部大会およびシンポジウム講演要旨集　50th　14　2016

  114. 過酸化リン脂質とビタミンE解析を通した肥満マウスにおける生体内酸化ストレス発生機序の評価

    伊藤隼哉, 佐藤洋介, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫, 宮澤陽夫

    日本栄養・食糧学会東北支部大会およびシンポジウム講演要旨集　50th　15　2016

  115. 高脂肪食投与後の糖尿病発症における過食,体重増加とレプチンとの関係:新規選抜交配モデルマウスの解析から

    浅井明, 浅井明, 長尾元嗣, 長尾元嗣, 川原百代, 加藤俊治, 宮澤陽夫, 杉原仁, 及川眞一

    糖尿病(Web)　59　(Suppl)　S.148(J‐STAGE)　2016

    ISSN： 1881-588X

  116. ナトリウムイオンの付加を利用したヒドロペルオキシドをはじめとする脂質分子のLC‐MS/MS分析

    仲川清隆, BERSABE Hannah, 清水直紀, 小舘愛, 乙木百合香, 伊藤隼哉, 加藤俊治, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　24th　6　2016

  117. リポタンパクの酸化機構とそれに関わる血漿の性質

    加藤俊治, 伊藤隼哉, 清水直紀, 宮澤陽夫, 宮澤陽夫, 仲川清隆

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　24th　7　2016

  118. キラルHPLC‐MS/MSを用いた生体内リン脂質ヒドロペルオキシドの生成機構の解析

    伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治, 宮澤陽夫, 宮澤陽夫

    日本生化学会大会(Web)　88回・38回　[3P0293]-[3P0293]　2015/12

    Publisher: (公社)日本生化学会

  119. LC‐MS/MSによる過酸化リン脂質光学異性体の解析

    伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治, 宮澤陽夫, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　150th　28　2015/10/03

  120. LC‐MS/MSによるコリン型及びエタノールアミン型プラズマローゲンの精密定量

    乙木百合香, 仲川清隆, 加藤俊治, 荒井啓行, 古川勝敏, 宮澤陽夫, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　150th　28　2015/10/03

  121. ナトリウムイオンの付加を利用した糖化脂質の新しい質量分析

    仲川清隆, 小舘愛, 乙木百合香, 伊藤隼哉, 加藤俊治, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本油化学会年会講演要旨集　54th　200　2015/09/08

    ISSN： 1348-6764

  122. 質量分析を用いた油脂酸化劣化の新規評価法の開発

    加藤俊治, 加藤俊治, 仲川清隆, 井関達也, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本油化学会年会講演要旨集　54th　197　2015/09/08

    ISSN： 1348-6764

  123. キラルHPLC‐MSIMSを用いたホスファチジルコリンヒドロペルオキシド(PCOOH)の立体異性体分離―生体内の脂質過酸化機構の解明に向けて―

    伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治, 宮澤陽夫, 宮澤陽夫

    日本油化学会年会講演要旨集　54th　199　2015/09/08

    ISSN： 1348-6764

  124. LC‐MS/MSによるコリン型及びエタノールアミン型プラズマローゲンの精密定量

    乙木百合香, 仲川清隆, 加藤俊治, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本油化学会年会講演要旨集　54th　198　2015/09/08

    ISSN： 1348-6764

  125. マヨネーズに含まれる極微量過酸化リン脂質の定量

    加藤俊治, 加藤俊治, 仲川清隆, 井関達也, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本食品科学工学会大会講演集　62nd　106　2015/08/27

  126. LC‐MS/MSによるヒト血漿過酸化リン脂質異性体の解析

    加藤俊治, 加藤俊治, 仲川清隆, 浅井明, 浅井明, 長尾元嗣, 永島和幸, 杉原仁, 及川眞一, 宮澤陽夫, 宮澤陽夫

    日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)　47th　214 (WEB ONLY)　2015/06/25

  127. LC‐MS/MSによるエタノールアミン型,コリン型プラズマローゲンの精密定量法の確立

    乙木百合香, 加藤俊治, 仲川清隆, 宮澤陽夫

    脂質生化学研究　57　168-169　2015/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  128. ホスファチジルコリンヒドロペルオキシド(PCOOH)の立体選択的解析―PCOOH生成機序の解明に向けて―

    伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治, 宮澤陽夫

    脂質生化学研究　57　233-235　2015/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  129. ヒト肝癌細胞における過酸化リン脂質PCOOHの代謝と作用:PCOOHの作用へのビタミンEの影響

    仲川清隆, 鈴木優里, 加藤俊治, 舘脇直人, 永塚貴弘, 西田浩志, 宮澤陽夫

    ビタミン　89　(4)　216-216　2015/04/25

    Publisher: 日本ビタミン学会

    ISSN： 0006-386X

  130. LC‐MS/MSによる生体過酸化リン脂質異性体の解析

    加藤俊治, 加藤俊治, 仲川清隆, 浅井明, 浅井明, 長尾元嗣, 永島和幸, 杉原仁, 及川眞一, 宮澤陽夫

    日本生化学会大会(Web)　88th　3P0290 (WEB ONLY)　2015

  131. 質量分析による油脂酸化劣化の評価法の開発

    加藤俊治, 加藤俊治, 仲川清隆, 井関達也, 半澤康彦, 木村ふみ子, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　23rd　8　2015

  132. リン脂質ヒドロペルオキシド(PCOOH)立体異性体のLC‐MS/MS分析

    伊藤隼哉, 仲川清隆, 加藤俊治, 永井利治, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　23rd　9　2015

  133. LC‐MS/MSによるヒト血漿過酸化リン脂質異性体の解析

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    ビタミン　88　(11)　587-588　2014/11/25

    Publisher: 公益社団法人 日本ビタミン学会

    DOI： 10.20632/vso.88.11_587 　

    ISSN： 0006-386X

  134. メタボリックシンドローム発症と生体内酸化ストレス:胎児プログラミングモデルを用いた解析

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本生化学会大会(Web)　87回　[3T15a-08]　2014/10

    Publisher: (公社)日本生化学会

  135. LC‐MS/MSによるヒト血漿過酸化リン脂質異性体の解析

    加藤俊治, 伊藤隼哉, 水落俊介, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本生化学会大会(Web)　87回　[2T09a-14]　2014/10

    Publisher: (公社)日本生化学会

  136. LC‐MS/MSによるエタノールアミン型,コリン型プラズマローゲンの精密定量法の確立

    乙木百合香, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本生化学会大会(Web)　87回　[2T09a-13]　2014/10

    Publisher: (公社)日本生化学会

  137. 脂肪酸ヒドロペルオキシドのキラル分析:PCOOH生成機序の解明に向けて

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本農芸化学会北海道支部講演会講演要旨　2014　44　2014/09/22

  138. 質量分析による生体過酸化リン脂質異性体の解析

    加藤俊治, 伊藤隼哉, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本農芸化学会北海道支部講演会講演要旨　2014　44　2014/09/22

  139. LC‐MS/MSによるエタノールアミン型およびコリン型プラズマローゲンの精密定量

    乙木百合香, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会北海道支部講演会講演要旨　2014　43　2014/09/22

  140. MS/MSによる脂肪酸ヒドロペルオキシドの新規解析法

    水落俊介, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　201　2014/09/09

    ISSN： 1348-6764

  141. 成熟ラットへの高脂肪食給与による肝機能低下と脂質過酸化

    早坂咲, 加藤俊治, 宮澤大樹, 木村ふみ子, 仲川清隆, 泉澤勝弘, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　96　2014/09/09

    ISSN： 1348-6764

  142. LC‐MS/MSによる生体過酸化リン脂質(PCOOH)の異性体解析

    加藤俊治, 伊藤隼哉, 水落俊介, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　200　2014/09/09

    ISSN： 1348-6764

  143. 母親の高脂肪食摂取が子供の脂質過酸化・脂質代謝に与える影響

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　97　2014/09/09

    ISSN： 1348-6764

  144. LC‐MS/MSによるエタノールアミン型およびコリン型プラズマローゲンの精密定量

    乙木百合香, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　199　2014/09/09

    ISSN： 1348-6764

  145. ヒト肝癌細胞HepG2におけるホスファチジルコリンヒドロペルオキシド(PCOOH)の代謝の病態生理

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　53rd　160　2014/09/09

    ISSN： 1348-6764

  146. 過酸化リン脂質異性体の精密定量による生体脂質過酸化機構の解明

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    脂質生化学研究　56　235-238　2014/05/28

    ISSN： 0285-1520

  147. 胎児プログラミングモデルにおける肥満・メタボリックシンドローム発症と生体内脂質過酸化

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    脂質生化学研究　56　69-70　2014/05

    Publisher: 日本脂質生化学会

    ISSN： 0285-1520

  148. ヒト肝癌細胞HepG2における過酸化リン脂質(PCOOH)代謝:病態生理学的作用との関係

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　68th　207　2014/04/30

  149. 高脂肪食給与ラットにおける食品抗酸化物質の生体内抗酸化作用の検証

    早坂咲, 加藤俊治, 宮澤大樹, 木村ふみ子, 仲川清隆, 泉澤勝弘, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　68th　208　2014/04/30

  150. 過酸化リン脂質の高純度異性体標品の作製とヒト血漿の分析

    水落俊介, 加藤俊治, 宮澤大樹, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　68th　195　2014/04/30

  151. LC-MS/MS determination of phosphatidylcholine hydroperoxide and its truncated products in human blood plasma

    Teruo Miyazawa, Shunji Kato, Kento Sawane, Taiki Miyazawa, Kiyotaka Nakagawa

    FASEB JOURNAL　28　(1)　2014/04

    ISSN： 0892-6638

    eISSN： 1530-6860

  152. 胎児・乳児期における高エネルギー状態は成長後の生体内酸化ストレスを増加させる

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　68回　208-208　2014/04

    Publisher: (公社)日本栄養・食糧学会

  153. LC‐MS/MSによるヒト血漿アラキドン酸型PCOOHの定量

    水落俊介, 加藤俊治, 宮澤大樹, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2014　3B04A05 (WEB ONLY)　2014/03/05

    ISSN： 2186-7976

  154. 過酸化リン脂質異性体の精密定量による生体酸化ストレスの評価

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2014　3B04A04 (WEB ONLY)　2014/03/05

    ISSN： 2186-7976

  155. 胎児・乳児期における過剰栄養状態は成長後の生体内脂質過酸化を亢進させる

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2014　2C02P08 (WEB ONLY)　2014/03/05

    ISSN： 2186-7976

  156. ヒト血漿過酸化リン脂質の異性体と分解物の量的関係について

    加藤俊治, 宮澤大樹, 澤根健人, 仲川清隆, 宮澤陽夫

    ビタミン　88　(2)　109-110　2014/02/25

    Publisher: 公益社団法人 日本ビタミン学会

    DOI： 10.20632/vso.88.2_109 　

    ISSN： 0006-386X

  157. 日本油化学会第53回年会に参加して：同時開催された第1回アジアオレオサイエンス会議での研鑽も含めて

    加藤俊治, 仲川清隆

    オレオサイエンス　14　587　2014

  158. LC‐MS/MSを用いたヒト血中過酸化リン脂質(PCOOH)の精密定量

    仲川清隆, 加藤俊治, 水落俊介, 浅井明, 長尾元嗣, 永島和幸, 及川眞一, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　21st　10　2014

  159. 生体過酸化リン脂質(PCOOH)異性体のLC‐MS/MS解析

    加藤俊治, 伊藤隼哉, 水落俊介, 仲川清隆, 浅井明, 及川眞一, 永島和幸, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　22nd　6　2014

  160. ヒト血漿に存在するPCOOH分解物のLC‐MS/MS分析

    仲川清隆, 澤根健人, 加藤俊治, 浅井明, 及川眞一, 宮澤陽夫, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　22nd　7　2014

  161. 質量分析を用いた新規酸化ストレス評価法の構築―過酸化リン脂質の異性体定量に着目して―

    加藤俊治

    日本農芸化学会東北支部シンポジウム講演要旨　2014　6　2014

  162. 過酸化リン脂質(PCOOH)の細胞内代謝と還元酵素との関係性

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　148th　30　2013/10/26

  163. MS/MSによるアラキドン酸型PCOOH位置異性体の定量分析

    水落俊介, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　148th　32　2013/10/26

  164. 血漿過酸化リン脂質の異性体解析による生体酸化ストレスの評価

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　148th　28　2013/10/26

  165. メタボリックシンドロームと生体脂質過酸化:乳児期マウスを用いた解析

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　148th　28　2013/10/26

  166. ヒト血漿に含まれるリン脂質酸化二次生成物のLC‐MS/MS分析

    澤根健人, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　52nd　159　2013/09/03

    ISSN： 1348-6764

  167. 質量分析を用いたヒト血中過酸化リン脂質の精密定量

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本油化学会年会講演要旨集　52nd　170　2013/09/03

    ISSN： 1348-6764

  168. ホスファチジルコリンヒドロペルオキシド(PCOOH)の培養ヒト肝癌細胞HepG2における代謝

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本油化学会年会講演要旨集　52nd　112　2013/09/03

    ISSN： 1348-6764

  169. 肥満・メタボリックシンドローム発症と生体内脂質過酸化:乳児期マウスを用いた解析

    伊藤隼哉, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    日本生化学会大会(Web)　86回　3LBA-040　2013/09

    Publisher: (公社)日本生化学会

  170. ヒト肝癌細胞HepG2における酸化リン脂質(PCOOH)の代謝

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　67th　118　2013/04/30

  171. 動脈硬化症患者血中PCOOHのLC‐MS/MS分析

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　67th　118　2013/04/30

  172. ヒト血漿に存在するPCOOH分解物のLC‐MS/MS分析

    澤根健人, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　67th　118　2013/04/30

  173. ヒト血漿に存在するリン脂質酸化二次生成物のLC‐MS/MS分析

    澤根健人, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2013　3C20P06 (WEB ONLY)　2013/03/05

    ISSN： 2186-7976

  174. LC‐MS/MSによるヒト血中PCOOHの精密定量分析

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2013　3C20P07 (WEB ONLY)　2013/03/05

    ISSN： 2186-7976

  175. 酸化リン脂質(PCOOH)のヒト肝癌細胞由来HepG2における代謝と生理作用

    鈴木優里, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2013　2A16P11 (WEB ONLY)　2013/03/05

    ISSN： 2186-7976

  176. LC‐MS/MSによるヒト血中過酸化リン脂質(PCOOH)の精密定量

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本生化学会大会(Web)　86th　1T19A-07(1LBA-014) (WEB ONLY)　2013

  177. 動脈硬化性疾患発症リスクの高い患者の血中PCOOH測定

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    ビタミン　86　(12)　693-694　2012/12/25

    Publisher: 公益社団法人 日本ビタミン学会

    DOI： 10.20632/vso.86.12_693 　

    ISSN： 0006-386X

  178. トコトリエノールによる中性脂肪代謝の改善:米糠トコトリエノールを利用した肥満になりたくない健康食品の開発に向けて

    仲川清隆, BURDEOS Gregor Carpentero, 加藤俊治, 小野瀬晋司, 明石直美, 木村ふみ子, 宮澤陽夫

    New Food Ind　54　(6)　35-43　2012/06/01

    Publisher: 食品資材研究会

    ISSN： 0547-0277

  179. 血中酸化ストレスマーカーであるPCOOH分子種のLC‐MS/MS精密定量分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　66th　134　2012/04/27

  180. 酸化ストレスマーカーであるPCOOHのLC‐MS/MS精密定量分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    ビタミン　86　(4)　285-285　2012/04/25

    Publisher: 日本ビタミン学会

    ISSN： 0006-386X

  181. DPPPを用いたリン脂質ヒドロペルオキシド測定系の開発とその応用

    幸村知子, 唐橋美奈子, 原川絵里香, 加藤俊治, 仲川清隆, 宮澤陽夫, 中川靖一

    日本薬学会年会要旨集　132nd　(3)　106　2012/03/05

    ISSN： 0918-9823

  182. リン脂質ヒドロペルオキシドによる血管新生の亢進:動脈硬化への関与分子機構

    仲川清隆, 齊藤達弥, 加藤俊治, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2012　4A08A07 (WEB ONLY)　2012/03/05

    ISSN： 2186-7976

  183. LC‐MS/MSによるヒト血中PCOOH分子種の高感度定量分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会大会講演要旨集(Web)　2012　4A08A10 (WEB ONLY)　2012/03/05

    ISSN： 2186-7976

  184. LC‐MS/MSによる動脈硬化症者血中PCOOHの精密定量分析

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　147th　54　2012

  185. LC‐MS/MSによるヒト血中PCOOH分子種の精密定量分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本生化学会大会(Web)　85th　2T04-05 (WEB ONLY)　2012

  186. リン脂質ヒドロペルオキシドから派生する酸化二次生成物のLC‐MS/MS分析

    澤根健人, 加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会東北支部大会およびシンポジウム講演要旨集　46th　5　2012

  187. 高LDL‐コレステロール血漿及び動脈硬化性疾患発症リスクの高い患者の血漿PCOOH測定

    加藤俊治, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　20th　21　2012

  188. 血中過酸化リン脂質(PCOOH)のMS/MS分析における注意点と解決法

    加藤俊治, 宮澤陽夫

    オレオサイエンス　11　(6)　221-222　2011/06/01

    DOI： 10.5650/oleoscience.11.221 　

    ISSN： 1345-8949

  189. ヒト血中ホスファチジルコリンヒドロペルオキシド(PCOOH)のLC‐MS/MS分析

    加藤俊治, 仲川清隆, 及川眞一, 宮澤陽夫

    脂質生化学研究　53　70-73　2011/04/28

    ISSN： 0285-1520

  190. ヒト血中ホスファチジルコリンヒドロペルオキシドのLC‐MS/MS分析における定量性と再現性の向上

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　65th　115　2011/04/25

  191. CL‐HPLC法によるヒト赤血球過酸化脂質の定量

    宮澤大樹, 仲川清隆, 加藤俊治, 宮澤陽夫

    日本栄養・食糧学会大会講演要旨集　65th　252　2011/04/25

  192. 血中ホスファチジルコリンヒドロペルオキシド(PCOOH)のLC‐MS/MS分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　146th　42　2011

  193. DPPPを用いたリン脂質ヒドロペルオキシド測定系の開発とその応用

    幸村知子, 唐橋美奈子, 原川絵里香, 加藤俊治, 仲川清隆, 宮澤陽夫, 中川靖一

    生化学　ROMBUNNO.2P-0108　2011

    ISSN： 0037-1017

  194. LC‐MS/MSによる血中PCOOHの定量分析

    加藤俊治, 仲川清隆, 宮澤陽夫

    日本過酸化脂質・抗酸化物質学会年会講演要旨集　19th　10　2011

  195. 動脈硬化症における血清ホスファチジルコリンヒドロペルオキシドのLC‐MS/MS分析

    加藤俊治, 横山覚, 仲川清隆, 宮澤陽夫

    日本農芸化学会東北支部大会プログラム・講演要旨集　145th　62　2010/09/27

  196. 心臓弁膜症患者における血清PCOOHの分析

    加藤俊治, 横山覚, 仲川清隆, 浅井明, 及川眞一, 宮澤陽夫

    日本農芸化学会大会講演要旨集　2010　225　2010/03/05

  197. LIPID PEROXIDATION IN HUMAN DISEASES AND ITS CONTROL WITH FOOD NUTRIENTS

    Taiki Miyazawa, Shunji Kato, Kiyotaka Nakagawa, Teruo Miyazawa

    ANNALS OF NUTRITION AND METABOLISM　55　323-323　2009

    ISSN： 0250-6807

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Books and Other Publications 3

  1. 医薬品/化粧品/食品分野におけるHPLC・GC分析テクニック

    加藤俊治, 仲川清隆

    （株）技術情報協会　2020/06

  2. 「紫外線をあびたら何を食べる？～酸化ストレスと抗酸化食品～」

    2020/01

  3. 食用油、保存に気をつけていますか？ ～油脂酸化の化学～

    2019/01

Presentations 33

  1. 食品中の多様なトリアシルグリセロール分子種の酸化解析

    加藤俊治, 境野眞善, 佐野貴史, 今義潤, 仲川清隆

    第31回ビタミンE研究会　2020/01/10

  2. 油脂中のトコフェロール酸化物の解析

    乙木百合香, 加藤俊治, 境野眞善, 仲川清隆

    第31回ビタミンE研究会　2020/01/10

  3. Structural analysis of lipid hydroperoxides using mass spectrometry: exploring cause of hydroperoxide generation Invited

    Shunji Kato

    International conference on clinical lipid nutrition　2019/11/19

  4. 質量分析を用いた様々な油脂の酸化原因の解析 Invited

    加藤 俊治

    第１９回基準油脂分析試験法セミナー　2019/11/14

  5. ヒト皮脂中のスクアレンの酸化機構解析

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚貴弘, 仲川清隆

    日本農芸化学会東北支部第154大会　2019/11/09

  6. LC-MS/MSを用いた脂質糖化産物の腸管吸収の評価

    梅津直生, 伊藤隼哉, 加藤俊治, 永塚貴弘, 仲川清隆

    第29回日本メイラード学会年会　2019/10/27

  7. リノール酸由来の6種のヒドロペルオキシド異性体とグリシンのメイラード反応

    仲川清隆, 伊藤隼哉, 加藤俊治, 永塚貴弘

    第29回日本メイラード学会年会　2019/10/27

  8. LC-MS/MS による DHA を多く含む藻類油の酸化特性の解析

    伊藤隼哉, 加藤俊治, 橋本革, 加藤真晴, 仲川清隆

    日本油化学会第58回年会　2019/09/26

  9. 食用油脂の高温加熱時に生成するトリアシルグリセロールヒドロペルオキシドの構造解析

    清水直紀, 加藤俊治, 境野眞善, 佐野貴士, 今義潤, 仲川清隆

    日本油化学会第58回年会　2019/09/26

  10. トリアシルグリセロールヒドロペルオキシド異性体解析によるオリーブオイル酸化機構の評価

    齋藤浩唯, 加藤俊治, 高橋隼登, 清水直紀, 境野眞善, 佐野貴士, 伊藤隼哉, 今義潤, 仲川清隆

    日本油化学会第58回年会　2019/09/26

  11. カチオン-π電子相互作用に基づく脂質ヒドロペルオキシドの異性体解析

    加藤俊治, 乙木百合香, 伊藤隼哉, 永塚貴弘, 仲川清隆

    日本油化学会第58回年会　2019/09/26

  12. 油の酸化って実は何？ Invited

    仲川清隆, 加藤俊治

    第59回東北大学農学カルチャー講座　2019/09/21

  13. 質量分析による肝臓中の脂質酸化機構の解明

    加藤俊治, 仲川清隆, 竹腰進

    第51回日本臨床分子形態学会　2019/09/20

  14. 食品に含まれる多様なトリアシルグリセロールの酸化メカニズム解析

    加藤俊治, 境野眞善, 佐野貴士, 仲川清隆

    日本食品科学工学会第66回大会　2019/08/30

  15. Evaluation of high thermal-oxidative stability of rice bran oil（RBO）via classical and modern mass spectrometric methods

    Rahmania Halida, Kazue Sawada, Shunji Kato, Hiroyuki Hashimoto, Kiyotaka Nakagawa

    日本食品科学工学会第66回大会　2019/08/30

  16. Evaluation of γ-Oryzanol Accumulation and Lipid Metabolism of Mouse Following A Long-Term Administration of γ-Oryzanol

    Junya Ito, Eri Kobayashi, Naoki Shimizu, Takumi Kokumai, Shunji Kato, Kazue Sawada, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    Asian Congress of Nutrition 2019　2019/08/27

  17. LC-MS/MS によるトリアシルグリセロールヒドロペルオキシドの吸収代謝の評価

    髙橋巧, 加藤俊治, 伊藤隼哉, 境野眞善, 佐野貴士, 今義潤, 池田郁男, 仲川清隆

    日本油化学会第58回年会　2019/08/26

  18. 透析患者血中の過酸化リン脂質異性体解析

    加藤俊治, 雨宮伸幸, 杉浦秀和, 仲川清隆

    日本過酸化脂質・抗酸化物質学会 第27回年会　2019/08/24

  19. 主要リポタンパクに含まれるコレステロールエステルおよびホスファチジルコリンのヒドロペルオキシド異性体解析

    大須賀佑輔, 加藤俊治, 伊藤隼哉, 永塚貴弘, 仲川清隆

    第61回 日本脂質生化学会　2019/07/05

  20. 質量分析によるトリアシルグリセロールヒドロペルオキシド分析法の構築

    加藤俊治, 竹腰進, 仲川清隆

    第61回 日本脂質生化学会　2019/07/05

  21. サメ肝油中スクアレンの酸化評価とα-トコフェロールによる酸化抑制

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚貴弘, 齋藤哲男, 西田浩志, 仲川清隆

    日本ビタミン学会第71回大会

  22. 質量分析による肝臓中のジアシルグリセロール酸化機構の解明

    加藤俊治, 仲川清隆, 竹腰進

    第26回肝細胞研究会

  23. 質量分析を用いた酸化脂質の構造解析 ：酸化脂質の構造は何を反映するか Invited

    加藤俊治, 竹腰進

    私立大学戦略的研究基盤形成支援事業 「臓器線維症の病態解明と新たな診断・予防・治療法開発のための拠点形成」 2019年度公開研究報告会　2019/05/14

  24. Analysis of plasmalogen species in serum and post-mortem brain tissue of Alzheimer’s disease patients

    Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa, Di Yu, Danielle J. Harvey, Lee-Way Jin, Britany N. Dugger, Walter Swardfager, Ameer Y. Taha

    American Oil Chemists’ Society (AOCS) Annual Meeting and Expo 2019　2019/05/07

  25. Determination of triacylglycerol oxidation mechanisms using liquid chromatography-tandem mass spectrometry

    Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

    American Oil Chemists’ Society (AOCS) Annual Meeting and Expo 2019　2019/05/07

  26. 様々な分子種からなるランダムエステル交換油の酸化機構の評価

    飯田彩未, 加藤俊治, 泉井亮太, 久保内宏晶, 仲川清隆

    日本農芸化学会2019年度大会

  27. LC-MS/MSを用いたオリーブ油の酸化メカニズム推定

    高橋隼登, 加藤俊治, 伊藤隼哉, 境野眞喜, 佐野貴士, 永塚貴弘, 宮澤陽夫, 仲川清隆

    日本農芸化学会2019年度大会

  28. 質量分析を用いた油脂初期酸化の新規評価法

    加藤俊治, 伊藤隼哉, 境野眞善, 佐野貴士, 永塚貴弘, 宮澤陽夫, 仲川清隆

    日本農芸化学会2019年度大会

  29. 質量分析を用いた様々な脂質クラスの酸化機構の解析

    加藤俊治, 竹腰進, 仲川清隆

    第30回ビタミンＥ研究会

  30. 製造や保存、調理におけるオリーブ油の酸化：酸化抑制へのビタミンEの寄与

    高橋隼登, 加藤俊治, 伊藤隼哉, 境野眞善, 佐野貴士, 永塚貴弘, 宮澤陽夫, 仲川清隆

    第30回ビタミンＥ研究会

  31. 油脂中のトコフェロール酸化物、とくにヒドロペルオキシド型の解析

    丹野玲菜, 加藤俊治, 伊藤隼哉, 小倉由資, 永塚貴弘, 桑原重文, 宮澤陽夫, 仲川清隆

    第30回ビタミンＥ研究会

  32. α-トコフェロールによるスクアレンの酸化抑制と抑制機構の評価

    清水直紀, 伊藤隼哉, 加藤俊治, 永塚隆弘, 宮澤陽夫, 仲川清隆

    第30回ビタミンＥ研究会

  33. 過酸化脂質とビタミンE解析を通した肥満マウスにおける酸化ストレスの評価

    伊藤隼哉, 佐藤洋介, 加藤俊治, 木村ふみ子, 仲川清隆, 宮澤陽夫

    第30回ビタミンＥ研究会

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Industrial Property Rights 3

  1. ゴマリグナンの定量方法

    Property Type: Patent

  2. 油脂の酸化原因の特定方法

    Property Type: Patent

  3. 油脂のアクロレイン生成能を評価する方法

    Property Type: Patent

Research Projects 13

  1. Establishment of a Novel Lipid Evaluation Technology for Simultaneous Visualization of Oxidation Progression and Its Underlying Causes

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2026/04/01 - 2029/03/31

  2. 新たな光酸化機構の提唱と光酸化抑制法の検討

    加藤 俊治

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2025/04/01 - 2028/03/31

  3. 新たな油脂資源としての昆虫油の確立〜持続可能な資源循環への挑戦〜

    Offer Organization: 生物系特定産業技術研究支援センター

    System: スタートアップ総合支援プログラム（SBIR支援）フェーズ2

    2026/04 - 2028/03

  4. Peroxide-omicsの体系化で脂質酸化の全貌の先(食品の未来品質・ヒトの健康社会)へ迫る

    仲川 清隆

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2025/04 - 2028/03

  5. Induction of cellular senescence by lipid hydroperoxides and its regulation by food components

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  6. 新たな油脂資源としての昆虫油の確立〜持続可能な資源循 環への挑戦〜

    Offer Organization: 生物系特定産業技術研究支援センター

    System: スタートアップ総合支援プログラム（SBIR支援）

    2025/04 - 2026/03

  7. Advancing Future Food Quality and Human Health through the Comprehensive Elucidation of Lipid Oxidation

    Nakagawa Kiyotaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

    More details Close

    Lipid oxidation is a major cause of food deterioration and disease, and its comprehensive elucidation remains a big challenge. In this study, we utilized our original LC-MS/MS method and computational chemistry to analyze the structure of lipid hydroperoxides, revealing distinct oxidation mechanisms and proposing fundamental principles underlying the formation of secondary oxidation products. Furthermore, we uncovered novel pathways for the formation of well-known highly reactive aldehydes, glyoxal and methylglyoxal. We also provided experimental validation for a longstanding hypothesis regarding the formation of aroma compounds from the oxidation of saturated fatty acids. Additionally, we clarified how oxidized lipids contribute to ferroptosis and how iron metabolism is involved. The results of these studies provide insights that may lead to improved food quality and disease prevention through the control of lipid oxidation.

  8. 脂質酸化全貌情報の精緻化から創造する食品の未来品質・ヒトの健康社会

    仲川 清隆, 永塚 貴弘, 加藤 俊治, 伊藤 隼哉, 乙木 百合香

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  9. Investigation of photooxidation mechanisms occurring in food and biological systems for the purpose of developing optimal control strategies.

    Kato Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

    More details Close

    In this study, we employed our original mass spectrometric methods and wavelength-specific light sources to investigate photooxidation mechanisms. In addition to the well-known Type I and Type II pathways, we newly identified a third type of photooxidation that occurs independently of photosensitizers. Specifically, radical formation was observed when linoleic acid was irradiated with ~550 nm light in the absence of any photosensitizers. Furthermore, in pork samples, photoirradiation induced significant oxidation of triacylglycerols, whereas phospholipids remained largely unaffected. In biological systems, we found that plasmalogens (Pls) react with singlet oxygen and rapidly undergo dehydration to yield harmless lipids, revealing a sophisticated quenching mechanism. These findings offer new insights into the control of photooxidative degradation in food and the mitigation of oxidative stress in biological systems.

  10. 新たな油糧資源としての昆虫油の確立

    Offer Organization: 東北大学

    System: BIP（ビジネス・インキュベーション・プログラム）フェーズ1

    2024/04 - 2025/03

  11. 精肉の光酸化機構の解析と光酸化抑制法の検討

    Offer Organization: 公益財団法人伊藤記念

    System: 伊藤記念財団令和6年度研究助成

    Institution: 東北大学農学研究科

    2024/04 - 2025/03

  12. Determination of hydrocarbon oxidation mechanisms by the analysis of the hydroperoxide isomeric structure

    Kato Shunji

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04/01 - 2022/03/31

    More details Close

    Of oxidized hydrocarbon structures, the hydroperoxyl group position is important information that provides the detail about its oxidation mechanisms. While we previously reported mass spectrometric methods using Na+ for the highly selective determination of hydroperoxyl group positions, nothing was known except for the fact that sodiated hydroperoxide provides specific fragment ions. Thus, this study firstly investigated the mechanisms that sodiated hydroperoxide provides specific fragment ions, assuming its further application to analysis of other complex oxidized hydrocarbons. And then, this method was appllied to the analysis of oxidized saturated and unsaturated hydrocarbons which were oxidized by thermal and photo oxidation. Moreover, since a novel photo oxidation was observed, the mechaism was investigated.

  13. Elucidation of the lipid oxidation mechanisms and their optimal control leading to a healthy- and food-based society of the future through the analysis of lipid hydroperoxides isomers

    Nakagawa Kiyotaka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2019/04/01 - 2022/03/31

    More details Close

    Lipid molecules in vivo are oxidized by several mechanisms (e.g., radical oxidation, enzymatic oxidation, and singlet oxygen oxidation), and the formation of lipid hydroperoxides leads to disturbances in biological functions. Oxidative degradation of oils/fats in foods is deeply related to food quality. Therefore, it is vital to determine oxidative mechanisms in vivo and food products. We have attempted to identify the lipid oxidation mechanisms by analyzing lipid hydroperoxides at the isomeric level using LC-MS/MS. In this study, we tried to develop analytical methods for lipid hydroperoxides and applied them to a wide range of biological and food samples. In addition, we have strived to elucidate the degradation mechanisms of these hydroperoxides.

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