Details of the Researcher

PHOTO

Ryo Ichinohasama
Section
Tohoku University Hospital
Job title
Specially Appointed Professor(Research)
Degree

  • Ph.D (Tokyo Medical and Dental University)

Education 2

  • Tokyo Medical and Dental University　Graduate School, Division of Medicine　病理学

    - 1986/03

  • Hirosaki University　Faculty of Medicine　医

    - 1982/03

Research Areas 1

  • Life sciences / Human pathology / Human Pathology

Papers 130

  1. Successful cord blood transplantation for a unique mature γδ T-cell leukemia with KMT2A::AFDN translocation.

    Satoshi Ichikawa, Shunsuke Hatta, Koichi Onodera, Tohru Fujiwara, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    Journal of clinical and experimental hematopathology : JCEH　66　(1)　108-110　2026/03/31

    DOI： 10.3960/jslrt.25063 　

  2. Mixed-phenotype acute leukemia with trilineage differentiation presenting as a non-leukemic mediastinal tumor.

    Satoshi Ichikawa, Maya Yamato, Shusuke Hatta, Koichi Onodera, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    Journal of clinical and experimental hematopathology : JCEH　2025/10/30

    DOI： 10.3960/jslrt.25045 　

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    Mixed-phenotype acute leukemia (MPAL) is an uncommon hematological malignancy, and cases exhibiting trilineage differentiation are extraordinarily rare. Here, we report the case of a 63-year-old male patient who presented with severe dyspnea secondary to a massive anterior mediastinal mass and pleural effusion, in the absence of detectable abnormal cells in the peripheral blood. Immunophenotypic analysis of pleural fluid and tumor biopsy revealed an unprecedented trilineage phenotype with concurrent expression of T-lymphoid (cytoplasmic CD3+ and CD7+), B-lymphoid (CD19+ and CD22+), myeloid (cytoplasmic MPO+ and CD33+) markers, along with stem cell (CD34+ and HLA-DR+), and lymphoblastic (TdT+) markers. B-lineage commitment was further confirmed by immunoglobulin heavy chain gene rearrangement. These findings established a diagnosis of T/B/myeloid triphenotypic MPAL presenting as an aleukemic disease with minimal bone marrow infiltration (<1%). Initial treatment with acute myeloid leukemia-directed induction therapy (daunorubicin plus cytarabine) proved refractory. However, the hyperCVAD regimen, which is an acute lymphoblastic leukemia (ALL)-directed approach, achieved a complete metabolic response. Subsequent consolidation with cord blood transplantation resulted in durable remission lasting 2 years before a late relapse, which occurred in the mediastinal region. This is the first reported case of non-leukemic, triphenotypic MPAL presenting as a primary mediastinal tumor, highlighting the diagnostic complexity and therapeutic challenges associated with this rare malignancy. Based on our experience, intensive ALL-directed chemotherapy followed by allogeneic stem cell transplantation may offer an effective therapeutic strategy for this exceptionally rare clinical entity.

  3. Rare nodal involvement as the initial presentation of lymphomatoid granulomatosis, mimicking metastatic carcinoma. International-journal

    Yuki Muroyama, Koichi Onodera, Akihisa Kawajiri, Takashi Suzuki, Ryo Ichinohasama

    Internal and emergency medicine　2025/10/28

    DOI： 10.1007/s11739-025-04175-z 　

  4. High FCGR2B Expression Can Identify Low-tumor-burden Follicular Lymphoma Patients Who Do Not Require Any Antilymphoma Therapy for a Long Term. International-journal

    Shotaro Watanabe, Hiroki Kato, Tohru Fujiwara, Shunsuke Hatta, Yasuo Tomiya, Koichi Onodera, Satoshi Ichikawa, Yasushi Onishi, Hisayuki Yokoyama, Fumiyoshi Fujishima, Ryo Ichinohasama, Hideo Harigae, Noriko Fukuhara

    The American journal of surgical pathology　49　(7)　740-747　2025/07/01

    DOI： 10.1097/PAS.0000000000002397 　

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    Spontaneous regression or a long-term lack of obvious progression is often observed in patients with low-tumor-burden (LTB) follicular lymphoma (FL). However, conventional prognostic risk models are unable to precisely identify the patients who will not require any antilymphoma treatment for a long term, especially at diagnosis. In this study, we identified genes whose expression levels were associated with the clinical outcome of LTB FL and verified their prognostic value using immunohistochemistry. Because the tumor microenvironment may influence FL pathogenesis, we used digital expression profiling to quantify the expression of 730 immune-related genes extracted from tumor tissue specimens collected from 55 untreated patients with LTB FL. Five genes were identified as potential transcriptomic predictive markers. Among these, FCGR2B , an inhibitory FC gamma receptor, was immunohistochemically stainable and identified as a reliable immunohistochemical prognostic marker mainly expressed in tumor cells but not in the surrounding reactive cells. Our findings could help identify patients with LTB FL who do not require any antilymphoma treatment for the long term.

  5. Methotrexate-associated Angioimmunoblastic T-cell Lymphoma Presenting with Acute Kidney Injury.

    Satoshi Ichikawa, Hikaru Kumagai, Koichi Onodera, Yoko Okitsu, Masahiro Kobayashi, Shori Abe, Fumiyoshi Fujishima, Ryo Ichinohasama, Junichi Kameoka, Tomonori Ishii

    Internal medicine (Tokyo, Japan)　2025/06/19

    DOI： 10.2169/internalmedicine.5578-25 　

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    A man in his 60s on methotrexate for rheumatoid arthritis developed a fever and lymph node swelling, suggesting a lymphoproliferative disorder. Methotrexate was discontinued; however, the patient was admitted for acute kidney injury (AKI) and thrombocytopenia. Blood tests showed high levels of inflammatory markers, positive plasma Epstein-Barr virus (EBV) DNA, and CD10-positive abnormal T cells, indicating T-cell neoplasm. CHOP chemotherapy with continuous hemodiafiltration improved the patient's condition. A lymph node biopsy confirmed the diagnosis of angioimmunoblastic T-cell lymphoma (AITL). To our knowledge, this is the first reported case of methotrexate-associated AITL complicated by AKI with a successful treatment course.

  6. 臍帯血移植により長期無病生存を得ているKMT2A遺伝子再構成陽性成熟γδT細胞腫瘍

    市川 聡, 八田 俊介, 小野寺 晃一, 福原 規子, 大西 康, 藤原 亨, 横山 寿行, 一迫 玲, 張替 秀郎

    日本リンパ腫学会会誌　65　129-129　2025/05

    Publisher: (一社)日本リンパ腫学会

  7. Angioimmunoblastic T-cell lymphoma harboring a t(8;14)(q24;q11.2)/TCR::MYC translocation that presented with intestinal infiltration. International-journal

    Satoshi Ichikawa, Hiroki Kato, Naoya Morota, Hiroaki Abe, Akihisa Kawajiri, Kyoko Inokura, Koichi Onodera, Yasushi Onishi, Noriko Fukuhara, Satoko Sato, Fumiyoshi Fujishima, Ryo Ichinohasama, Hideo Harigae

    Annals of hematology　2024/12/18

    DOI： 10.1007/s00277-024-06148-2 　

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    Although rearrangement of the MYC oncogene (MYC-R) is frequently observed in aggressive B-cell lymphomas, it is extremely rare in T-cell malignancies. A 64-year-old man who had been under observation for several years because of asymptomatic pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma) was admitted to our hospital because of poor general condition and hypotension. Blood tests revealed thrombocytopenia and elevated serum lactate dehydrogenase levels, whereas computed tomography revealed systemic lymphadenopathy and splenomegaly. An inguinal lymph node biopsy precipitated a diagnosis of angioimmunoblastic T-cell lymphoma (AITL). Shortly after admission, the patient experienced spontaneous intestinal perforation and hemorrhage caused by multiple intestinal infiltrations of the AITL. Although chemotherapy was administered, the patient died several weeks after admission. A 46,XY,t(8;14)(q24;q11.2) karyotype was identified, and fluorescence in situ hybridization analyses showed split signals for the MYC and T-cell receptor (TCR) alpha genes, by which a TCR::MYC translocation was confirmed. Pathological autopsy analysis revealed systemic infiltration of the AITL and no MALToma lesions. Only a few cases of mature T-cell lymphoma harboring MYC-R have been reported in the literature thus far. To the best of our knowledge, this is the first reported case of AITL with TCR::MYC rearrangement. This condition could be associated with refractoriness to chemotherapy and aggressive clinical course with systemic infiltration that included the intestine.

  8. Common progenitor origin for Rosai-Dorfman disease and clear cell sarcoma. International-journal

    Aki Sato, Nozomi Yusa, Hiroyuki Takamori, Eigo Shimizu, Kazuaki Yokoyama, Satoshi Ichikawa, Hisayuki Yokoyama, Yuki Kasahara, Kodai Enda, Fumiyoshi Fujishima, Ryo Ichinohasama, Yasunori Ota, Seiya Imoto, Yasuhito Nannya

    The Journal of pathology　264　(3)　243-249　2024/11

    DOI： 10.1002/path.6345 　

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    Histiocytic neoplasms (HNs) in adults have been reported to be associated with a high prevalence of coexisting haematological and solid malignancies. While a proportion of coexisting HNs and haematological malignancies share identical genetic alterations, the genetic association between HNs and solid malignancies has scarcely been reported. We report a case of Rosai-Dorfman disease (RDD) complicated by coexisting clear cell sarcoma (CCS). RDD is a rare HN. CCS is an ultrarare soft tissue sarcoma with a poor prognosis. Mutation analysis with whole-exome sequencing revealed six shared somatic alterations including NRAS p.G12S and TP53 c.559+1G>A in both the RDD and CCS tissue. This is the first evidence of a clonal relationship between RDD and solid malignancies using mutational analysis. We hypothesise that neural crest cells, which originate in CCS, are likely the common cells of origin for RDD and CCS. This case helps to unravel the underlying clinicopathological mechanisms of increased association of solid malignancies in HNs. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

  9. t(8;14)(q24;q11.2)/TCR::MYCを伴った血管免疫芽球性T細胞リンパ腫

    市川 聡, 加藤 浩貴, 諸田 直哉, 安部 宇明, 川尻 昭寿, 猪倉 恭子, 中川 諒, 八田 俊介, 小野寺 晃一, 福原 規子, 大西 康, 横山 寿行, 藤島 史喜, 一迫 玲, 張替 秀郎

    日本血液学会学術集会　86回　P2-6　2024/10

    Publisher: (一社)日本血液学会

  10. t(8;14)(q24;q11.2)/TCR::MYCを伴った血管免疫芽球性T細胞リンパ腫

    市川 聡, 加藤 浩貴, 諸田 直哉, 安部 宇明, 川尻 昭寿, 猪倉 恭子, 中川 諒, 八田 俊介, 小野寺 晃一, 福原 規子, 大西 康, 横山 寿行, 藤島 史喜, 一迫 玲, 張替 秀郎

    日本血液学会学術集会　86回　P2-6　2024/10

    Publisher: (一社)日本血液学会

  11. 低悪性度濾胞性リンパ腫から移行したダブルヒット濾胞性リンパ腫(DHFL)の1例

    末永 司, 阿部 正理, 小林 匡洋, 野村 順, 沖津 庸子, 高橋 伸一郎, 一迫 玲, 亀岡 淳一

    臨床血液　65　(4)　283-283　2024/04

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  12. Diffuse large B-cell lymphoma of the skull vault.

    Satoshi Ichikawa, Hisayuki Yokoyama, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    International journal of hematology　119　(3)　215-216　2024/03

    DOI： 10.1007/s12185-024-03717-z 　

  13. Successful Allogeneic Hematopoietic Stem Cell Transplantation for Nodal Epstein-Barr Virus-positive T/NK-cell Lymphoma

    Satoshi Ichikawa, Hiroaki Abe, Naoya Morota, Akihisa Kawajiri, Ryo Nakagawa, Kyoko Inokura, Shunsuke Hatta, Yuna Katsuoka, Koichi Onodera, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

    Internal Medicine　2024

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.4672-24 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  14. 初発時限局病変として発症し治療後に再発した節外性NK/T細胞リンパ腫の予後

    鳴海 善洋, 市川 聡, 福原 則子, 小野寺 晃一, 大西 康, 横山 寿行, 一迫 玲, 張替 秀郎

    日本血液学会学術集会　85回　293-293　2023/10

    Publisher: (一社)日本血液学会

  15. EBV関連節性細胞障害性T細胞リンパ腫は極めてアグレッシブな臨床経過を辿る

    市川 聡, 福原 規子, 横山 寿行, 八田 俊介, 沖津 庸子, 小野寺 晃一, 大西 康, 一迫 玲, 張替 秀郎

    日本血液学会学術集会　85回　1472-1472　2023/10

    Publisher: (一社)日本血液学会

  16. 【新リンパ腫学-基礎・臨床の最新動向-】病型各論 疾患概念・疫学・分類・臨床像・診断・治療・予後・話題 バーキットリンパ腫

    市川 聡, 大西 康, 一迫 玲

    日本臨床　81　(増刊3 新リンパ腫学)　298-302　2023/03

    Publisher: (株)日本臨床社

    ISSN： 0047-1852

  17. 著明な血小板減少を伴った血管免疫芽球性T細胞リンパ腫の1例

    渡邉 樹也, 市川 聡, 鳴海 善洋, 中村 嘉詞, 櫻井 一貴, 猪倉 恭子, 小松 弘香, 竹中 健太, 橋本 和貴, 内堀 雄介, 小野寺 晃一, 福原 規子, 大西 康, 横山 寿行, 一迫 玲, 張替 秀郎

    臨床血液　63　(11)　1588-1588　2022/11

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  18. Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation.

    Masahiro Miyazaki, Satoshi Ichikawa, Yasushi Onishi, Noriko Fukuhara, Eijiro Furukawa, Koichi Onodera, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

    Journal of clinical and experimental hematopathology : JCEH　62　(3)　164-168　2022/06/22

    DOI： 10.3960/jslrt.22003 　

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    ALK-positive anaplastic large cell lymphoma (ALK+ ALCL) has a favorable prognosis in general; however, some cases are resistant to chemotherapy, which leads to a poor clinical outcome. We herein report the case of a 32-year-old male with aggressive ALK+ ALCL who presented with hemorrhage from a large tumor in the duodenum and multiple tumors in the lungs, mediastinum, and peritoneal cavity. Although induction chemotherapy resulted in a marked reduction of the tumor lesions, premature progression with massive pulmonary infiltration and central nervous system invasion occurred immediately after the completion of chemotherapy. The patient was then promptly treated with brentuximab vedotin (BV) and high-dose methotrexate, which resulted in complete remission. Subsequently, he successfully underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from an unrelated donor and has been healthy and did not relapse for more than 3 years after transplantation without any additional therapy. Allo-HSCT may be a promising treatment option for ALK+ ALCL due to its graft-versus-lymphoma effect. In addition, molecular targeting agents, such as BV, may be promising as a bridging therapy before allo-HSCT to achieve disease remission.

  19. Peritoneal lymphomatosisによって腹部コンパートメント症候群を来したB細胞性リンパ腫の1例

    田中 悠也, 小野寺 晃一, 木葉 大地, 諸田 直哉, 道又 大吾, 小野 浩弥, 猪倉 恭子, 市川 聡, 福原 規子, 大西 康, 横山 寿行, 一迫 玲, 張替 秀郎

    臨床血液　63　(5)　491-492　2022/05

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  20. Aleukemic T-lymphoblastic leukemia/lymphoma with massive cerebrospinal fluid infiltration

    Ichikawa, S., Fukuhara, N., Doman, T., Kiba, D., Tanaka, Y., Inokura, K., Morota, N., Ono, K., Onodera, K., Onishi, Y., Yokoyama, H., Ichinohasama, R., Harigae, H.

    Journal of Hematopathology　15　(2)　105-109　2022

    DOI： 10.1007/s12308-022-00495-7 　

    ISSN： 1865-5785 1868-9256

    eISSN： 1865-5785

  21. Anaplastic multiple myeloma with MYC rearrangement. International-journal

    Satoshi Ichikawa, Noriko Fukuhara, Ko Hashimoto, Fumiyoshi Fujishima, Ryo Ichinohasama, Hideo Harigae

    Leukemia research reports　17　100288-100288　2022

    DOI： 10.1016/j.lrr.2021.100288 　

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    A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.

  22. Utility of a new notation to visualize flow cytometry analysis results: first preliminary comparison with immunohistochemistry to detect CD30 expression on T-cell lymphoma cells. International-journal

    Fumiyoshi Fujishima, Noriko Fukuhara, Hiroki Katsushima, Yasuhiro Nakamura, Hideo Harigae, Hironobu Sasano, Ryo Ichinohasama

    BMC cancer　21　(1)　1352-1352　2021/12/20

    DOI： 10.1186/s12885-021-09098-4 　

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    BACKGROUND: It is important to confirm CD30 expression in T-cell lymphoma cases, but immunohistochemical staining for CD30 is not commonly performed and no comparison has been done between the results of flow cytometry (FCM) and immunohistochemical staining for CD30. Therefore, we devised a notation that we termed proportion of immunoreactivity/expression for FCM (PRIME-F notation), based on the cellular proportion showing different antigen-antibody reactivity. METHODS: We retrospectively compiled 211 cases of T-cell lymphoma, assessed via FCM, from major hospitals in Miyagi Prefecture from January 2012 to January 2019, and compared 52 of these cases with the immunohistochemical immunoreactive (IR) pattern of CD30 (PRIME-I notation). The PRIME-F notation was divided into five levels: notations starting with "-" followed by 3, 2, and 1 ">" correspond to level-I, level-II, or level-III; notations starting with "(dim)+" correspond to level-IV; and those starting with "+" or "(bright)+" correspond to level-V. RESULTS: The 52 cases of PRIME-F notation with "+" included 16 cases of peripheral T-cell lymphoma (PTCL/NOS), 3 of follicular T-cell lymphoma (FTL), 3 of angioimmunoblastic T-cell lymphoma (AITL), 6 of extranodal NK/T-cell lymphoma/nasal type (ENKL), 18 of adult T-cell lymphoma (ATL), and 6 cases of anaplastic large cell lymphoma (ALCL). Eight of the 52 cases were immunohistochemically CD30-negative. In the PRIME-F level-I to III group (excluding false-positive cases), 21.7% (5 out of 23 cases) were < 10% positive for CD30 upon immunohistochemistry (IHC). Contrarily, in the level-IV & -V group, no CD30 positivity rate of < 10% upon IHC was found (0%) (p = 0.0497). In level-IV, 42.9% of cases presented a CD30 negative rate > 1/3 upon IHC, while in level-V, only 7.1% (one out of 14 cases) did. The CD30 negative rate tended to be low (p = 0.0877) in level-V. CONCLUSIONS: To our knowledge, this is the first report describing the correspondence between FCM and immunohistochemistry findings for CD30 through newly proposed notations. The PRIME-F and PRIME-I notations for CD30 showed a minor positive correlation. The PRIME notation is considered universally applicable to antibodies, and notations of both FCM and IHC show great potential for big data.

  23. Diffuse Large B-cell Lymphoma Presenting as Peritoneal Lymphomatosis: A Case Report and Literature Review.

    Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Koichi Onodera, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

    Internal medicine (Tokyo, Japan)　61　(13)　2057-2060　2021/12/11

    DOI： 10.2169/internalmedicine.8793-21 　

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    Peritoneal lymphomatosis (PL) is a rare presentation of malignant lymphoma cases, many of which are diagnosed as diffuse large B-cell lymphoma (DLBCL) and characterized by aggressive clinical courses. We herein report a 63-year-old woman presenting with the rapid development of abdominal distention due to bulky peritoneal tumors. The pathological evaluation of a needle biopsy sample, combined with flow cytometry, yielded the diagnosis of DLBCL. Prompt chemotherapeutic intervention resulted in favorable disease control and sustained complete remission. It is necessary to diagnose cases of DLBCL presenting as PL early to ensure prompt treatment and prevent mortality.

  24. Sustained remission of giant pancreatic plasmacytoma with daratumumab. International-journal

    Satoshi Ichikawa, Eijiro Furukawa, Kei Saito, Noriko Fukuhara, Koichi Onodera, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

    Annals of hematology　100　(10)　2633-2634　2021/10

    DOI： 10.1007/s00277-020-04145-9 　

  25. A novel case of γδ T cell leukemia with recurrent genetic abnormalities accompanied by agranulocytosis. International-journal

    Satoshi Ichikawa, Tohru Fujiwara, Kei Saito, Noriko Fukuhara, Hisayuki Yokoyama, Shunsuke Hatta, Koichi Onodera, Yasushi Onishi, Fumiyoshi Fujishima, Ryo Ichinohasama, Hideo Harigae

    Annals of hematology　100　(10)　2665-2668　2021/10

    DOI： 10.1007/s00277-020-04241-w 　

  26. 当科における臓器移植後リンパ増殖性疾患の経験

    渡邊 正太郎, 福原 規子, 櫻井 一貴, 橋本 和貴, 古川 瑛次郎, 道又 大吾, 猪倉 恭子, 小野寺 晃一, 市川 聡, 大西 康, 横山 寿行, 藤島 史喜, 一迫 玲, 張替 秀郎

    日本リンパ網内系学会会誌　61　98-98　2021/05

    Publisher: (一社)日本リンパ網内系学会

    ISSN： 1342-9248

    eISSN： 1883-681X

  27. Spontaneous Regression of Blastic Plasmacytoid Dendritic Cell Neoplasm Following Sepsis by Serratia marcescens: A Case Report and Literature Review Peer-reviewed

    Akane Suzuki, Shori Abe, Kaori Koyama, Shinju Suzuki, Munenori Nagao, Masahiro Kobayashi, Jun Nomura, Tomomi Tsutsumi, Tomoki Takeda, Yumiko Oka, Yuko Shirota, Naruhiko Takasawa, Takao Kodera, Yoko Okitsu, Shinichiro Takahashi, Ryo Ichinohasama, Junichi Kameoka

    Internal Medicine　60　(6)　927-933　2021/03/15

    Publisher: Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.5820-20 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  28. 抗tocilizumab抗体を検出しrituximabが奏功したTAFRO症候群

    渡邉 真威, 勝岡 優奈, 横山 寿行, 伊藤 俊広, 一迫 玲

    仙台医療センター医学雑誌　11　(1)　20-25　2021/02

    Publisher: (独)国立病院機構仙台医療センター

    ISSN： 2186-0920

    eISSN： 2186-3946

  29. Successful Treatment of Primary Refractory Angioimmunoblastic T-cell Lymphoma With Cord Blood Transplantation. International-journal

    Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Eijiro Furukawa, Koichi Onodera, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

    Clinical lymphoma, myeloma & leukemia　20　(11)　e926-e929　2020/11

    DOI： 10.1016/j.clml.2020.07.009 　

  30. 血管免疫芽球性T細胞リンパ腫の経過中に発症したEBウイルス陽性末梢性T細胞リンパ腫、非特定型

    渡邉 真威, 勝岡 優奈, 横山 寿行, 伊藤 俊広, 中村 直哉, 一迫 玲

    仙台医療センター医学雑誌　10　104-108　2020/10

    Publisher: (独)国立病院機構仙台医療センター

    ISSN： 2186-0920

    eISSN： 2186-3946

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    症例は65歳男性で、血管免疫芽球性T細胞リンパ腫(AITL)の診断でCHOP療法6コース施行直後に発熱・盗汗を認めた。治療効果判定のPET-CTで骨髄全域に集積を認め、骨髄生検では初発時のAITLと異なる表面形質を示し、Epstein-Barr virus陽性peripheral T-cell lymphoma(EBV-PTCL)、not otherwise specifiedの診断に至った。ICE療法により全身状態は改善したが骨髄の腫瘍残存を認め、SMILE療法を1コース施行後cord blood transplantationを施行した。Day23に末梢血液検査で完全ドナーキメリズムを達成したが、Day28の骨髄検査でEBV-PTCLの移植後早期再発を確認し、原病の進行を認めDay37に多臓器不全で死亡した。

  31. Extranasal extranodal NK/T-cell lymphoma associated with systemic lupus erythematosus.

    Satoshi Ichikawa, Noriko Fukuhara, Tsuyoshi Shirai, Tomonori Ishii, Ryo Ichinohasama, Hideo Harigae

    International journal of hematology　112　(4)　592-596　2020/10

    DOI： 10.1007/s12185-020-02914-w 　

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    Increased incidence of lymphoproliferative disorders is reported in patients with autoimmune diseases, majority of which have a B-cell phenotype and are pathogenetically associated with the reactivation of Epstein-Barr virus (EBV). However, EBV-associated T/NK-cell lymphoma has hardly been reported. We present the case of a 68-year-old-woman, who had been diagnosed with systemic lupus erythematosus (SLE) 28 years back and was treated with various immunosuppressive agents including steroids, cyclophosphamide, and tacrolimus. She presented with a progressively worsening swelling of the right thigh for the last few months. Radiological examination revealed an intramuscular bulky tumor without any other lesions and the biopsy results led to a diagnosis of extranodal NK/T-cell lymphoma, nasal type (ENKL). Concurrent chemoradiotherapy resulted in a complete response, which has been sustained for more than 2 years without requiring additional therapy. After the initiation of chemotherapy, SLE did not worsen with the administration of low-dose corticosteroids. To the best of our knowledge, this is the first case report of a localized extranasal ENKL developing in a patient with SLE.

  32. BCR-ABL1 positive lymphoblastic lymphoma - should it be treated like a B-lymphoblastic leukemia with t(9;22);BCR-ABL1? International-journal Peer-reviewed

    Taro Takahashi, Satoshi Ichikawa, Ryo Ichinohasama, Hideo Harigae

    LEUKEMIA & LYMPHOMA　61　(5)　1265-1267　2020/04

    DOI： 10.1080/10428194.2019.1706736 　

    ISSN： 1042-8194

    eISSN： 1029-2403

  33. 節外性NK/T細胞リンパ腫の同種移植後早期再発に対して短期L-asparaginase投与が著効した1例

    市川 聡, 福原 規子, 齋藤 慧, 横山 寿行, 田中 悠也, 李 尹河, 小野寺 晃一, 大西 康, 一迫 玲, 張替 秀郎

    臨床血液　61　(4)　418-418　2020/04

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  34. Primary ovarian diffuse large B-cell lymphoma preceded by autoimmune hemolytic anemia Peer-reviewed

    Satoshi Ichikawa, Asami Sasaoka, Noriko Fukuhara, Yoko Okitsu, Yasushi Onishi, Ryo Ichinohasama, Hideo Harigae

    Journal of Hematopathology　13　(1)　63-67　2020/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s12308-019-00377-5 　

    ISSN： 1868-9256

    eISSN： 1865-5785

  35. Epstein-Barr virus-positive diffuse large B-cell lymphoma after sustained remission of T-cell prolymphocytic leukemia with alemtuzumab. International-journal Peer-reviewed

    Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Hisayuki Yokoyama, Koichi Onodera, Yasushi Onishi, Ryo Ichinohasama, Hideo Harigae

    Leukemia & lymphoma　1-4　2020/01/21

    DOI： 10.1080/10428194.2020.1713322 　

  36. Successful treatment of methotrexate-associated classical Hodgkin lymphoma with brentuximab vedotin-combined chemotherapy: a case series. Peer-reviewed

    Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Koichi Onodera, Tsuyoshi Shirai, Yasushi Onishi, Hisayuki Yokoyama, Hiroshi Fujii, Ryo Ichinohasama, Hideo Harigae

    International journal of hematology　2020/01/18

    DOI： 10.1007/s12185-020-02822-z 　

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    Methotrexate (MTX)-associated classical Hodgkin lymphoma (CHL) is unlikely to regress following discontinuation of MTX, and its treatment usually requires chemotherapy. Standard chemotherapy for CHL is the ABVD regimen, which contains pneumotoxic bleomycin. This can be problematic in MTX-CHL patients suffering from an autoimmune disease (AID), such as rheumatoid arthritis (RA), as they frequently have pulmonary complications. However, brentuximab vedotin (BV)-containing chemotherapy without bleomycin (A + AVD regimen) was recently reported to show favorable efficacy for CHL, and could therefore be beneficial in MTX-CHL. We treated three cases of MTX-CHL using the A + AVD regimen. All were female and had received MTX for more than 15 years. Underlying AIDs in these patients were RA in two patients, and overlap syndrome with systemic lupus erythematosus and dermatomyositis in one patient. The A + AVD regimen resulted in a complete response in all patients. Peripheral neuropathy developed in two patients, necessitating reduction of the BV dose. All three patients experienced hematological toxicity necessitating dose reduction; however, no severe adverse effects, including infection or pulmonary complication, were documented. RA was well-controlled without additional immunosuppressants. The A + AVD regimen is a promising chemotherapy for MTX-CHL with favorable efficacy and tolerable toxicity profiles.

  37. Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review. International-journal

    Satoshi Ichikawa, Kei Saito, Noriko Fukuhara, Hisayuki Yokoyama, Koichi Onodera, Yasushi Onishi, Ryo Ichinohasama, Hideo Harigae

    Leukemia research reports　14　100223-100223　2020

    DOI： 10.1016/j.lrr.2020.100223 　

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    A 37-year-old man was admitted to our department following the detection of bulky tumors in his bilateral adrenal glands. A biopsy resulted in the diagnosis of extranodal NK/T cell lymphoma, nasal type (ENKL). After debulking by chemotherapy, allogeneic hematopoietic stem cell transplantation (alloHCT) was performed. Relapses in the liver and adrenal glands were identified 2 months post alloHCT, for which temporary administration of l-asparaginase resulted in complete metabolic response. However, multiple relapses in the central nervous system and lethal lymphomatous meningitis successively developed. Primary adrenal ENKL could tend to present as bulky lesion and follow an aggressive clinical course.

  38. Immunohistochemical pattern of c-MYC protein judged as '+/(weak)+/-' by a new notation correlates with MYC gene non-translocation in large B-cell lymphoma. International-journal Peer-reviewed

    Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Usubuchi H, Sato S, Ota Y, Yashima-Abo A, Nakamura T, Nakaya N, Harigae H, Sasano H, Ichinohasama R

    Human pathology　85　112-118　2018/11

    DOI： 10.1016/j.humpath.2018.10.025 　

    ISSN： 0046-8177

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    Immunohistochemistry is not only the most important tool for pathologists to establish a final diagnosis, but it can also inform decisions regarding optimal treatment methods. However, there is no universal standard notation for expressing immunohistochemical findings. For a diagnosis of malignant lymphoma, it is important to confirm the presence or absence of MYC translocation and communicate these results to a clinical audience. However, the criteria for selecting cases for fluorescence in situ hybridization (FISH) analysis to confirm MYC translocation are ill defined. We therefore devised a notation that we termed proportion of immunoreactivity/expression for immunohistochemistry (PRIME notation) based on the cellular proportion showing different antigen-antibody reactivity in immunohistochemistry (CPAR) and used it to examine the relationship between MYC translocation and the proportion of c-MYC+ lymphoma cells. We reviewed 82 cases diagnosed as diffuse large B-cell lymphoma or diffuse large B-cell lymphoma coexisting with grade 3A to 3B follicular lymphoma. The most common notation was "+/(weak)+/-" (49/82 cases [59.8%]); cases that were CPAR positive, weakly positive, and negative for tumor cells each accounted for about one-third of the total. Unexpectedly, no MYC translocation was observed by FISH in this group. Thus, FISH is not needed even if more than half of cells are c-MYC positive by PRIME notation. This is the first report describing a correspondence between immunohistochemical findings and chromosomal abnormality, reflecting findings at the protein and gene levels, respectively.

  39. Successful Treatment of Aggressive Mature B-cell Lymphoma Mimicking Immune Thrombocytopenic Purpura. Peer-reviewed

    Ono K, Onishi Y, Kobayashi M, Ichikawa S, Hatta S, Watanabe S, Okitsu Y, Fukuhara N, Ichinohasama R, Harigae H

    Internal medicine (Tokyo, Japan)　57　(17)　2573-2579　2018/09

    DOI： 10.2169/internalmedicine.0560-17 　

    ISSN： 0918-2918

  40. Sustained Remission of γδ T-Cell Lymphoma by Graft-Versus-Lymphoma Effect That Relapsed Early After Cord Blood Transplantation. Peer-reviewed

    Ichikawa S, Fukuhara N, Onishi Y, Ichinohasama R, Harigae H

    Clinical lymphoma, myeloma & leukemia　18　(9)　e369-e372　2018/09

    DOI： 10.1016/j.clml.2018.06.019 　

    ISSN： 2152-2650

  41. Safety and efficacy of high-dose ranimustine (MCNU) containing regimen followed by autologous stem cell transplantation for diffuse large B-cell lymphoma. Peer-reviewed

    Kameoka Y, Akagi T, Murai K, Noji H, Kato Y, Sasaki O, Ito S, Ishizawa K, Ishida Y, Ichinohasama R, Harigae H, Takahashi N

    International journal of hematology　108　(5)　510-515　2018/07

    DOI： 10.1007/s12185-018-2508-1 　

    ISSN： 0925-5710

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    High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is widely used as a salvage therapy for relapsed or high-risk diffuse large B-cell lymphoma (DLBCL). To investigate the safety and efficacy of regimens including high-dose MCNU followed by ASCT for DLBCL, we analyzed the data from prospective multicenter trials. Twenty-nine patients were analyzed, and the median follow-up time for survival patients was 70 months. Fifteen patients received MCVC conditioning regimen, and fourteen patients received MEAM regimen. Major toxicities associated with these conditioning regimens included nausea (69%), anorexia (66%), febrile neutropenia (62%), diarrhea (59%), and mucositis (34%). One patient who developed severe sinusoidal obstructive syndrome and acute lung injury died without disease progression, and overall therapy-related mortality at 5 years was 3%. No patient developed therapy-related hematological malignancy. At 5 years, overall survival and progression-free survival in all patients were 82.8 and 58.2%, respectively. The 5-year OS in patients treated by the MCVC and MEAM regimens were 73.3 and 92.9%, respectively. These results suggest that regimens including high-dose MCNU followed by ASCT are feasible and effective for the treatment of relapsed or high-risk DLBCL. Further investigation is needed to evaluate of these regimens.

  42. Successful Cord Blood Stem Cell Transplantation for Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated with Cerebral Infiltration. Peer-reviewed

    Ichikawa S, Fukuhara N, Hatta S, Himuro M, Katsushima H, Nasu K, Ono K, Inokura K, Kobayashi M, Onishi Y, Fujii H, Ishizawa K, Ichinohasama R, Harigae H

    Internal medicine (Tokyo, Japan)　57　(14)　2051-2055　2018/07

    DOI： 10.2169/internalmedicine.0568-17 　

    ISSN： 0918-2918

  43. Classical Hodgkin lymphoma-type and monomorphic-type post-transplant lymphoproliferative disorder following liver transplantation: a case report. Peer-reviewed

    Kumata H, Nakanishi C, Murakami K, Miyagi S, Fukuhara N, Carreras J, Nakamura N, Ichinohasama R, Unno M, Kamei T, Sasano H

    Surgical case reports　4　(1)　72　2018/07

    DOI： 10.1186/s40792-018-0480-x 　

  44. Incidence Rate, Subtype Frequency, and Occurrence Site of Malignant Lymphoma in the Gastrointestinal Tract: Population-Based Analysis in Miyagi, Japan. Peer-reviewed

    Fujishima F, Katsushima H, Fukuhara N, Konosu-Fukaya S, Nakamura Y, Sasano H, Ichinohasama R

    The Tohoku journal of experimental medicine　245　(3)　159-165　2018/07

    DOI： 10.1620/tjem.245.159 　

    ISSN： 0040-8727

  45. Does double-hit follicular lymphoma with translocations of MYC and BCL2 change the definition of transformation? Peer-reviewed

    Katsushima H, Fukuhara N, Konosu-Fukaya S, Himuro M, Kitawaki Y, Ichikawa S, Ishizawa K, Sasano H, Harigae H, Ichinohasama R

    Leukemia & lymphoma　59　(3)　758-762　2018/03

    DOI： 10.1080/10428194.2017.1357172 　

    ISSN： 1042-8194

  46. Anaplastic multiple myeloma: possible limitations of conventional chemotherapy for long-term remission. Peer-reviewed

    Ichikawa S, Fukuhara N, Hatta S, Himuro M, Nasu K, Ono K, Okitsu Y, Kobayashi M, Onishi Y, Ri M, Ichinohasama R, Harigae H

    Journal of clinical and experimental hematopathology : JCEH　58　(1)　39-42　2018

    DOI： 10.3960/jslrt.17035 　

    ISSN： 1346-4280

  47. Comprehensive analysis of vitreous specimens for uveitis classification: a prospective multicentre observational study. Peer-reviewed

    Maruyama K, Inaba T, Sugita S, Ichinohasama R, Nagata K, Kinoshita S, Mochizuki M, Nakazawa T

    BMJ open　7　(11)　e014549　2017/11

    DOI： 10.1136/bmjopen-2016-014549 　

  48. An Lysophosphatidic Acid Receptors 1 and 3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells and Promotes Growth and Vascularization of Multiple Myeloma Peer-reviewed

    Masahiko Kanehira, Tohru Fujiwara, Shinji Nakajima, Yoko Okitsu, Yasushi Onishi, Noriko Fukuhara, Ryo Ichinohasama, Yoshinori Okada, Hideo Harigae

    STEM CELLS　35　(3)　739-753　2017/03

    DOI： 10.1002/stem.2499 　

    ISSN： 1066-5099

    eISSN： 1549-4918

  49. Non-biased and complete case registration of lymphoid leukemia and lymphoma for five years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture. Peer-reviewed

    Katsushima H, Fukuhara N, Ichikawa S, Ota Y, Takeuchi K, Ishizawa K, Sasano H, Harigae H, Ichinohasama R

    Leukemia & lymphoma　58　(1)　80-88　2017/01

    DOI： 10.1080/10428194.2016.1183254 　

    ISSN： 1042-8194

  50. Inhibition of human primary megakaryocyte differentiation by anagrelide: a gene expression profiling analysis. Peer-reviewed

    Sakurai K, Fujiwara T, Hasegawa S, Okitsu Y, Fukuhara N, Onishi Y, Yamada-Fujiwara M, Ichinohasama R, Harigae H

    Int J Hematol.　104　(2)　190-199　2016/08

    DOI： 10.1007/s12185-016-2006-2 　

  51. Advanced Lymphocyte-rich Classical Hodgkin Lymphoma Complicated with Fatal Hemophagocytic Syndrome Peer-reviewed

    Satoshi Ichikawa, Taro Takahashi, Hiroki Katsushima, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    INTERNAL MEDICINE　55　(2)　191-196　2016

    DOI： 10.2169/internalmedicine.55.5942 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  52. First case of primary intraocular natural killer t-cell lymphoma. Peer-reviewed

    Maruyama K, Kunikata H, Sugita S, Mochizuki M, Ichinohasama R, Nakazawa T

    BMC ophthalmology　15　169　2015/11

    DOI： 10.1186/s12886-015-0158-0 　

  53. 【副腎腫瘍の新しいマネジメント】 副腎原発悪性リンパ腫の臨床病理学的特徴 Peer-reviewed

    市川 聡, 福原 規子, 一迫 玲, 張替 秀郎

    腎臓内科・泌尿器科　2　(4)　2015/10

  54. Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma Peer-reviewed

    Kameoka Y, Takahashi N, Itou S, Kume M, Noji H, Kato Y, Ichikawa Y, Sasaki O, Motegi M, Ishiguro A, Tagawa H, Ishizawa K, Ishida Y, Ichinohasama R, Harigae H

    Int J Hematol　101　(6)　536-42　2015/03/05

    DOI： 10.1007/s12185-015-1763-7 　

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    Angioimmunoblastic T-cell lymphoma (AITL) is a distinct peripheral T-cell lymphoma entity exhibiting peculiar clinical features and poor prognosis. Its clinical characteristics and prognostic factors are not well established. To clarify the clinical characteristics and prognostic features of AITL, we conducted a multicenter, retrospective study. Fifty-six patients were enrolled. The median patient age was 68 years. Immunohistochemical examinations of tumor cells showed positivity for CD10 and T-cell markers, and chromosomal examination detected several types of abnormalities. More than 80 % of patients show advanced disease at diagnosis and poor prognostic scores. A high proportion of patients showed accompanying B symptoms, splenomegaly, and hepatomegaly at diagnosis. The 5-year overall survival (OS) rate was 48 % and progression-free survival was 25 %. Univariate analysis revealed higher age, fever, poor performance status, anemia, and low albumin level to be poor prognostic factors for OS. In addition to these factors, both IPI and PIT were also predictive of OS. Multivariate analysis indicated only a low level of serum albumin to be a significant prognostic factor for OS. Serum albumin may be one of the important prognostic factors for AITL. Further investigation is needed to confirm these results.

  55. びまん性大細胞型B細胞リンパ腫におけるBACH2発現の臨床病学的意義 Peer-reviewed

    市川聡, 福原規子, 一迫玲

    血液内科　82-86　2015

  56. Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy. Peer-reviewed

    Kyogoku C, Seki M, Ogawa S, Miyamoto K, Ito Y, Kurita N, Yokoyama Y, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Fujishima F, Ichinohasama R, Nakamura S, Chiba S

    Journal of clinical and experimental hematopathology : JCEH　55　(1)　33-37　2015

    Publisher: The Japanese Society for Lymphoreticular Tissue Research

    DOI： 10.3960/jslrt.55.33 　

    ISSN： 1346-4280

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    Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.

  57. Effect of 5-aminolevulinic acid on erythropoiesis: A preclinical in vitro characterization for the treatment of congenital sideroblastic anemia Peer-reviewed

    Tohru Fujiwara, Koji Okamoto, Ryoyu Niikuni, Kiwamu Takahashi, Yoko Okitsu, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ryo Ichinohasama, Yukio Nakamura, Motowo Nakajima, Tohru Tanaka, Hideo Harigae

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　454　(1)　102-108　2014/11

    DOI： 10.1016/j.bbrc.2014.10.050 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  58. Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma Peer-reviewed

    Satoshi Ichikawa, Noriko Fukuhara, Hiroki Katsushima, Taro Takahashi, Joji Yamamoto, Hisayuki Yokoyama, Osamu Sasaki, Osamu Fukuhara, Jun Nomura, Kenichi Ishizawa, Ryo Ichinohasama, Akihiko Muto, Kazuhiko Igarashi, Hideo Harigae

    CANCER SCIENCE　105　(4)　437-444　2014/04

    DOI： 10.1111/cas.12361 　

    ISSN： 1347-9032

    eISSN： 1349-7006

  59. 3-Deazaneplanocin A (DZNep), an Inhibitor of S-Adenosylmethionine-dependent Methyltransferase, Promotes Erythroid Differentiation Peer-reviewed

    Tohru Fujiwara, Haruka Saitoh, Ai Inoue, Masahiro Kobayashi, Yoko Okitsu, Yuna Katsuoka, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ryo Ichinohasama, Hideo Harigae

    JOURNAL OF BIOLOGICAL CHEMISTRY　289　(12)　8121-8134　2014/03

    DOI： 10.1074/jbc.M114.548651 　

    ISSN： 0021-9258

    eISSN： 1083-351X

  60. Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis. Peer-reviewed

    Ichikawa S, Fukuhara N, Inoue A, Katsushima H, Ohba R, Katsuoka Y, Onishi Y, Yamamoto J, Sasaki O, Nomura J, Fukuhara O, Ishizawa K, Ichinohasama R, Harigae H

    Experimental hematology & oncology　2　(1)　19　2013/08

    DOI： 10.1186/2162-3619-2-19 　

  61. T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. Peer-reviewed

    Ichikawa S, Watanabe Y, Saito K, Kimura J, Ichinohasama R, Harigae H

    Experimental hematology & oncology　2　(1)　1　2013/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1186/2162-3619-2-1 　

    eISSN： 2162-3619

  62. A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. Peer-reviewed

    Fujiwara Tohru, Ikeda Takashi, Nagasaka Yuki, Okitsu Yoko, Katsuoka Yuna, Fukuhara Noriko, Onishi Yasushi, Ishizawa Kenichi, Ichinohasama Ryo, Tomosugi Naohisa, Harigae Hideo

    PLoS One　8　(9)　e75568-e75568　2013

    DOI： 10.1371/journal.pone.0075568 　

  63. Immunoglobulin G4-positive plasmablastic lymphoma. Peer-reviewed

    Yokoyama H, Inomata M, Fujiwara-Yamada M, Ito T, Meguro K, Ichinohasama R

    Leukemia & lymphoma　53　(10)　2075-2077　2012/10

    DOI： 10.3109/10428194.2012.668680 　

    ISSN： 1042-8194

    eISSN： 1029-2403

  64. CD20-positive and CD4/CD8-double-negative peripheral T-cell lymphoma of spleen complicated with severe disseminated intravascular coagulation and enteropathy. Peer-reviewed

    Ichikawa S, Hatta S, Saito Y, Kimura J, Onishi K, Matsuda M, Ichinohasama R, Harigae H

    Journal of clinical and experimental hematopathology : JCEH　52　(2)　133-136　2012

    Publisher: The Japanese Society for Lymphoreticular Tissue Research

    DOI： 10.3960/jslrt.52.133 　

    ISSN： 1346-4280

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    A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3+, CD4-, CD8-, T-cell receptor (TCR)αβ+, and TCRγδ-. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20+ PTCL-NOS. Although it is a rare disease entity, CD20+ T-cell lymphoma can demonstrate aggressive clinical behavior. [J Clin Exp Hematopathol 52(2) : 133-136, 2012]

  65. Successful treatment with bortezomib and thalidomide for POEMS syndrome. Peer-reviewed

    Ohguchi H, Ohba R, Onishi Y, Fukuhara N, Okitsu Y, Yamamoto J, Ishizawa K, Ichinohasama R, Harigae H

    Annals of hematology　90　(9)　1113-1114　2011/09

    DOI： 10.1007/s00277-010-1133-8 　

    ISSN： 0939-5555

  66. A case of benign natural killer cell proliferative disorder of the stomach (gastric manifestation of natural killer cell lymphomatoid gastroenteropathy) mimicking extranodal natural killer/T-cell lymphoma. Peer-reviewed

    Yamamoto Joji, Fujishima Fumiyoshi, Ichinohasama Ryo, Imatani Akira, Asano Naoki, Harigae Hideo

    Leuk Lymphoma　52　(9)　1803-1805　2011/09

    DOI： 10.3109/10428194.2011.573030 　

  67. Clinicopathological Features of Malignant Lymphoma in Japan: The Miyagi Study Peer-reviewed

    Yukiko Miura, Noriko Fukuhara, Joji Yamamoto, Katsura Kohata, Kenichi Ishizawa, Ryo Ichinohasama, Hideo Harigae

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　224　(2)　151-160　2011/06

    DOI： 10.1620/tjem.224.151 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  68. False-Positive Human Immunodeficiency Virus Antibody Test and Autoimmune Hemolytic Anemia in a Patient with Angioimmunoblastic T-Cell Lymphoma Peer-reviewed

    Seiji Shida, Naoto Takahashi, Naohito Fujishima, Yoshihiro Kameoka, Miho Nara, Masumi Fujishima, Hirobumi Saitoh, Hiroyuki Tagawa, Makoto Hirokawa, Ryo Ichinohasama, Kenichi Sawada

    INTERNAL MEDICINE　50　(20)　2383-2387　2011

    DOI： 10.2169/internalmedicine.50.5764 　

    ISSN： 0918-2918

  69. Comparison of long-term clinical outcomes of CHOP chemotherapy between Japanese patients with nodal peripheral T-cell lymphomas and those with diffuse large B-cell lymphoma in the study group of the Tohoku Hematology Forum Peer-reviewed

    AKAGI, Tomoaki, TAKAHASHI, Naoto, YAMAGUCHI, Kouhei, ISHIZAWA, Kenichi, MURAI, Kazunori, TAJIMA, Katsushi, IKEDA, Kazuhiko, KAMEOKA, Yoshihiro, KAMEOKA, Junichi, ITO, Shigeki, KATO, Yuichi, NOJI, Hideyoshi, SHICHISHIMA, Tsutomu, ITOH, Jugoh, ICHINOHASAMA, Ryo, HARIGAE, Hideo, ISHIDA, Yoji, SAWADA, Kenichi

    Journal of Clinical and Experimental Hematopathology　51　(1)　29-35　2011

    eISSN： 1880-9952

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    To clarify the clinical outcome of peripheral T-cell lymphomas (PTCLs), we conducted a retrospective review comparing the outcomes of patients with PTCL (nodal peripheral T-cell lymphoma, unspecified, n=34 ; angioimmunoblastic T-cell lymphoma, n=12) to those with diffuse large B-cell lymphoma (DLBCL, n=48). All patients received CHOP-based chemotherapy without rituximab. PTCL patients presented at a more advanced clinical stage (91% vs. 65%, P<0.002) with a poorer performance status (26% vs. 17%, P<0.002) than DLBCL patients. The complete response rate among PTCL patients was significantly lower than among DLBCL patients (39% vs. 67%, P<0.008), as was the 3-year overall survival rate (26% vs. 50%, P=0.005), and Cox multivariate analysis revealed immunophenotype, performance status, and extranodal site involved to be significantly associated with shorter overall survival (P=0.045, P=0.007, and P=0.034, respectively). Our findings suggest that PTCL patients tend to have a poor prognosis associated with several initial risk factors. Moreover, the T-cell phenotype itself appears to have a significant impact on overall survival. Thus, standard CHOP chemotherapy may be inadequate for PTCLs, especially in patients with high-risk factors. The development of newly stratified therapies for the treatment of PTCLs would be highly desirable.

  70. Paraimmunoblastic variant of small lymphocytic lymphoma/chronic lymphocytic leukemiaの一例

    勝岡 優奈, 大西 康, 阿部 正理, 猪股 美津恵, 横山 寿行, 伊藤 俊広, 一迫 玲, 目黒 邦昭

    臨床血液　51　(9)　1173-1173　2010/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  71. Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide. Peer-reviewed

    Ichinohasama R, Oji Y, Yokoyama H, Takeuchi K, Fujiwara T, Ishizawa K, Taniguchi O, Tsuboi A, Oka Y, Sugiyama H

    Cancer science　101　(5)　1089-1092　2010/05

    Publisher: 5

    DOI： 10.1111/j.1349-7006.2010.01522.x 　

    ISSN： 1347-9032

  72. Japanese case of follicular lymphoma of ocular adnexa diagnosed by clinicopathologic, immunohistochemical, and molecular genetic techniques. Peer-reviewed

    Otomo Takaaki, Fuse Nobuo, Ishizawa Kenichi, Seimiya Motohiko, Shimura Masahiko, Ichinohasama Ryo

    Clin Ophthalmol　4　1397-1402　2010/04

    DOI： 10.2147/OPTH.S15219 　

  73. Extreme eosinophilia caused by interleukin-5-producing disseminated colon cancer. Peer-reviewed

    Kato Hiroki, Kohata Katsura, Yamamoto Joji, Ichikawa Satoshi, Watanabe Mika, Ishizawa Kenichi, Ichinohasama Ryo, Harigae Hideo

    Int J Hematol　91　(2)　328-330　2010/03

    DOI： 10.1007/s12185-010-0491-2 　

    ISSN： 0925-5710

  74. 宮城県における悪性リンパ腫の調査研究：ＭＩＹＡＧＩ Study Peer-reviewed

    張替秀郎, 一迫玲

    血液・腫瘍　60　(1)　83-88　2010/01/28

    Publisher:

    ISSN： 0915-8529

  75. Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia. International-journal Peer-reviewed

    Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo Y-M, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, Sawada K

    Blood.　114　(15)　3265-3275　2009

    DOI： 10.1182/blood-2009-06-222794 　

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    The gene(s) responsible for natural killer (NK)-cell lymphoma/leukemia have not been identified. In the present study, we found that in NK-cell lymphoma lines (n = 10) and specimens of primary lymphoma (n = 10), levels of miR-21 and miR-155 expression were inversely related and were significantly greater than those found in normal natural killer (CD3(-)CD56(+)) cells (n = 8). To determine the functions of these microRNAs in lymphomagenesis, we examined the effects of antisense oligonucleotides (ASOs) targeting miR-21 (ASO-21) and/or miR-155 (ASO-155) in NK-cell lymphoma lines overexpressing one or both of these miRNAs. Conversely, cells showing little endogenous expression of miR-21 or miR-155 were transduced by the use of lentiviral vectors, leading to their overexpression. Reducing expression of miR-21 or miR-155 led to up-regulation of phosphatase and tensin homologue (PTEN), programmed cell death 4 (PDCD4), or Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1). ASO-21- and ASO-155-treated cell lines all showed down-regulation of phosphorylated AKT(ser473). Moreover, transduction with either miR-21 or miR-155 led to down-regulation of PTEN and PDCD4 or SHIP1 with up-regulation of phosphorylated AKT(ser473). Collectively, these results provide important new insight into the pathogenesis of NK-cell lymphoma/leukemia and suggest targeting miR-21 and/or miR-155 may represent a useful approach to treating NK-cell lymphoma/leukemia.

  76. Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis. Peer-reviewed

    Shirai T, Takahashi R, Tajima Y, Kohata K, Yamamoto J, Fujii H, Takasawa N, Ishizawa K, Ichinohasama R, Ishii T, Harigae H

    Internal medicine (Tokyo, Japan)　48　(23)　2041-2045　2009

    Publisher: The Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.48.2600 　

    ISSN： 0918-2918

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    Here, we present a 54-year-old man with proptosis and swelling below the left eyelid. Laboratory findings showed high levels of PR3-ANCA and histological examination of the first biopsy revealed acute inflammation. Together with the findings of MRI, a diagnosis of WG was made. However, the disease progressed rapidly and histological examination of the second biopsy revealed infiltration of neoplastic T lymphocytes with aberrant loss of CD7. A final diagnosis of peripheral T cell lymphoma, not otherwise specified (WHO) was made, and complete remission was achieved by chemotherapy. This is a very rare case of T cell lymphoma with a high titer of PR3-ANCA.<br>

  77. Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. Peer-reviewed

    Suzuki N, Katsusihma H, Takeuchi K, Nakamura S, Ishizawa K, Ishii S, Moriya T, DeCoteau JF, Miura I, Ichinohasama R

    Cancer genetics and cytogenetics　186　(1)　54-57　2008/10

    DOI： 10.1016/j.cancergencyto.2008.06.002 　

    ISSN： 0165-4608

  78. Differential diagnosis of the disease to cause a cervix lymphadenopathy

    ICHINOHASAMA Ryo

    Journal of Oral Surgery Society of Japan　54　(8)　480-483　2008/08/20

    Publisher: Japanese Society of Oral and Maxillofacial Surgeons

    DOI： 10.5794/jjoms.54.480 　

    ISSN： 0021-5163

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    Diagnosis of malignant lymphoma should be made basically morphological observation with HE specimen as well as data by multimeric analyses. Otherwise there are some cases that cannot obtain a precise diagnosis. In addition, pathologists must understand the characteristics of many subclassification of lymphoma enough, and based on the knowledge, it becomes often necessary to add various kinds of analysises.

  79. De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients. Peer-reviewed

    Yamaguchi M, Nakamura N, Suzuki R, Kagami Y, Okamoto M, Ichinohasama R, Yoshino T, Suzumiya J, Murase T, Miura I, Ohshima K, Nishikori M, Tamaru J, Taniwaki M, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S

    Haematologica　93　(8)　1195-1202　2008/08

    DOI： 10.3324/haematol.12810 　

    ISSN： 0390-6078

  80. Successful treatment of advanced extranodal NK/T cell lymphoma with unrelated cord blood transplantation. Peer-reviewed

    Yokoyama Hisayuki, Yamada Minami F, Ishizawa Kenichi, Yamamoto Joji, Tomiya Yasuo, Harigae Hideo, Kameoka Junichi, Ichinohasama Ryo, Sasaki Takeshi

    Tohoku J Exp Med　211　(4)　395-399　2007/04

    DOI： 10.1620/tjem.211.395 　

  81. Aggressive B-cell lymphoma with dual surface immunoglobulin light-chain expression. Peer-reviewed

    Fujiwara Tohru, Ishizawa Kenichi, Kohata Katsura, Yamamoto Joji, Yamada Minami F, Kameoka Junichi, Ichinohasama Ryo, Harigae Hideo

    Intern Med　46　(17)　1458-1461　2007/04

    Publisher: The Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.46.0128 　

    ISSN： 0918-2918

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    Dual surface immunoglobulin light-chain expression in B-cell malignant neoplasm is a rare event, and has been predominantly reported in chronic lymphocytic leukemia. Herein, we report a case of aggressive B-cell lymphoma with κ/λ-dual surface immunoglobulin light-chain expression of a 69-year-old woman. The lymphoma cells were positive for CD5, CD19, CD20, HLA-DR, Igκ and Igλ. Southern blot analysis confirmed rearranged bands for both light chains with a monoclonal heavy chain rearrangement. She was treated with a combination of rituximab and CHOP regimen, but died of the progressive disease. To our knowledge, this is the first case of aggressive B-cell lymphoma showing dual κ/λ expression; the possible mechanisms of abnormal light chain expression are discussed.<br>

  82. Indurated nodules and plaques showing a dense plasma cell infiltrate as a cutaneous manifestation of Castleman's disease. Peer-reviewed

    Okuyama R, Harigae H, Moriya T, Kagatani S, Tagami H, Ichinohasama R, Aiba S

    Br J Dermatol　156　(1)　174-176　2007/01

    DOI： 10.1111/j.1365-2133.2006.07577.x 　

  83. Recurrent classic Kaposi's sarcoma in a Japanese man: detection of human herpesvirus 8 infection by PCR and immunostaining Peer-reviewed

    Kusakari Y, Okuyama R, Hashimoto A, Ichinohasama R, Terui T, Tagami H, Aiba S

    J Eur Acad Dermatol Venereol　21　(1)　112-113　2007/01

  84. The first infant case with hepatosplenic gammadelta T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation. Peer-reviewed

    Shinichiro Y Koga, Satoru Kumaki, Ryo Ichinohasama, Mitsutoshi Munakata, Kazuhiro Haginoya, Yoshiyuki Ohashi, Yoshiko Tanaka, Osamu Sakamoto, Masayoshi Minegishi, Tomohiro Morio, Kazuie Iinuma, Shigeru Tsuchiya

    J. Pediatr. Hematol. Oncol.　28　(11)　741-745　2006/11

    DOI： 10.1097/01.mph.0000243649.43863.8f 　

    ISSN： 1077-4114

  85. Diffuse Large B-cell Lymphoma Arising in a Patient with Neurofibromatosis Type I and in a Patient with Neurofibromatosis Type II

    DOHI OSAMU, HATORI MASAHITO, ICHINOHASAMA RYO, HOSAKA MASAMI, HASHIMOTO SHO, KOKUBUN SHOICHI

    Tohoku J. Exp. Med.　208　(2)　169-176　2006/02/01

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.208.169 　

    ISSN： 0040-8727

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    We experienced two unusual cases of diffuse large B-cell lymphoma (DLBCL), which occurred in a patient with neurofibromatosis type I and a patient with neurofibromatosis type II. B-cell lymphoma is one of the most common phenotypic subgroups of malignant lymphoma. Neurofibromatosis I is characterized by café-au-lait spots and neurofibromas. Neurofibromatosis II typically consists of bilateral schwannomas of the acoustic nerve. Malignant lymphomas rarely coexist with neurofibromatosis I, and no coexistence with neurofibromatosis II has been reported. The patient with neurofibromatosis I was a 50-year-old Japanese woman, clinically manifesting von Recklinghausen's disease since infancy, who noticed an egg-sized tumor in her shoulder. The patient with neurofibromatosis II was a 39-year-old Japanese man who noticed multiple soft tissue tumors in his neck, buttock, and elbow. Biopsied materials from both cases were examined by multiparameter methods, including flow cytometry. Flow cytometry revealed large-scale cells to be tumor cells, and they were positive for CD19, CD20, and CD22. Both patients received chemotherapy, and the tumors disappeared. The patient with neurofibromatosis I was alive without recurrence at 4 years after treatment, while the patient with neurofibromatosis II died of recurrence. To the best of our knowledge, this is the first case of malignant lymphoma arising in a neurofibromatosis II patient. As for neurofibromatosis I, there were some reports about occurrence of malignant lymphoma. It is important to be aware of possibility of association of malignant tumors not only of the nervous system but also of unrelated to the nervous system when tumors appear in neurofibromatosis patients.

  86. 濾胞性リンパ腫初回治療におけるRituximab療法

    山本 譲司, 横山 寿行, 門脇 育子, 遠宮 靖雄, 藤原 実名美, 石澤 賢一, 張替 秀郎, 亀岡 淳一, 一迫 玲, 佐々木 毅

    日本血液学会・日本臨床血液学会総会プログラム・抄録集　67回・47回　925-925　2005/09

    Publisher: 日本臨床血液学会

  87. Accelerated lymphangiogenesis in malignant lymphoma: possible role of VEGF-A and VEGF-C. Peer-reviewed

    Kadowaki Ikuko, Ichinohasama Ryo, Harigae Hideo, Ishizawa Kenichi, Okitsu Yoko, Kameoka Junichi, Sasaki Takeshi

    Br J Haematol　130　(6)　869-877　2005/09

    DOI： 10.1111/j.1365-2141.2005.05695.x 　

  88. Pattern expression system of flow cytometry for immunophenotyping on malignant lymphoma

    ICHINOHASAMA Ryo, DECOTEAU John F.

    Cytometry Research　15　(1)　1-9　2005/04/01

    Publisher: Japan Cytometry Society

    DOI： 10.18947/cytometryresearch.15.1_1 　

    ISSN： 0916-6920

  89. Cytogenetic features of de novo CDS-positive diffuse large B-cell lymphoma: Chromosome aberrations affecting 8p21 and 11q13 constitute major subgroups with different overall survival

    T Yoshioka, Miura, I, M Kume, N Takahashi, M Okamoto, R Ichinohasama, T Yoshino, M Yamaguchi, M Hirokawa, K Sawada, S Nakamura

    GENES CHROMOSOMES & CANCER　42　(2)　149-157　2005/02

    DOI： 10.1002/gcc.20127 　

    ISSN： 1045-2257

  90. CD5(+) diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region Peer-reviewed

    N Nakamura, S Nakamura, M Yamaguchi, R Ichinohasama, T Yoshino, T Kuze, Y Sasaki, S Yoshida, M Abe

    INTERNATIONAL JOURNAL OF HEMATOLOGY　81　(1)　58-61　2005/01

    DOI： 10.1532/IJH97.04119 　

    ISSN： 0925-5710

  91. Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23)

    T Fujiwara, R Ichinohasama, Miura, I, T Sugawara, H Harigae, H Yokoyama, S Takahashi, Y Tomiya, M Yamada, K Ishizawa, J Kameoka, T Sasaki

    CANCER GENETICS AND CYTOGENETICS　156　(1)　49-53　2005/01

    DOI： 10.1016/j.cancergencyto.2004.04.013 　

    ISSN： 0165-4608

  92. Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia Peer-reviewed

    SA Scott, T Kimura, WF Dong, R Ichinohasama, S Bergen, A Kerviche, D Sheridan, JF DeCoteau

    LEUKEMIA RESEARCH　28　(12)　1293-1301　2004/12

    DOI： 10.1016/j.leukres.2004.03.019 　

    ISSN： 0145-2126

  93. A case of primary mucosa-associated lymphoid tissue lymphoma of the vagina Peer-reviewed

    K Yoshinaga, JI Akahira, H Niikura, N Ito, T Moriya, T Murakami, JI Kameoka, R Ichinohasama, K Okamura, N Yaegashi

    HUMAN PATHOLOGY　35　(9)　1164-1166　2004/09

    DOI： 10.1016/j.humpath.2004.06.002 　

    ISSN： 0046-8177

  94. PTC gene mutations and expression of SHH, PTC, SMO and GLI-1 in odontogenic keratocysts Peer-reviewed

    K Ohki, H Kumamoto, R Ichinohasama, T Sato, N Takahashi, K Ooya

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY　33　(6)　584-592　2004/09

    DOI： 10.1016/j.ijom.2004.01.013 　

    ISSN： 0901-5027

    eISSN： 1399-0020

  95. Multiparameter analysis for discreet differential diagnosis of mucosa-associated lymphoid tissue lymphoma in the intestine Peer-reviewed

    E Nomura, S Takagi, R Ichinohasama, T Kikuchi, M Shiraki, S Oomori, H Yokoyama, K Utsunomiya, K Negoro, H Aihara, S Takahashi, Y Kinouchi, T Shimosegawa

    IN VIVO　18　(4)　437-441　2004/07

    ISSN： 0258-851X

  96. Detection of clone-specific immunoglobulin heavy chain genes in the bone marrow of B-cell-lineage lymphoma after treatment Peer-reviewed

    A Hoshino, T Funato, Y Munakata, T Ishii, S Abe, K Ishizawa, R Ichinohasama, J Kameoka, K Meguro, T Sasaki

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　203　(3)　155-164　2004/07

    DOI： 10.1620/tjem.203.155 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  97. Detection of bone marrow infiltration of lymphoma cells by fluorescence in situ hybridization Peer-reviewed

    K Ishizawa, Y Obara, O Seki, S Fujimaki, J Kameoka, R Ichinohasama, K Kanemitsu, T Sasaki, M Kaku, H Harigae

    CLINICA CHIMICA ACTA　344　(1-2)　79-82　2004/06

    DOI： 10.1016/j.cccn.2004.02.014 　

    ISSN： 0009-8981

  98. Periampullary tumors: High-spatial-resolution MR imaging and histopathologic findings in ampullary region specimens Peer-reviewed

    R Sugita, A Furuta, K Ito, N Fujita, R Ichinohasama, S Takahashi

    RADIOLOGY　231　(3)　767-774　2004/06

    DOI： 10.1148/radiol.2313030797 　

    ISSN： 0033-8419

  99. No evidence of a correlation between BCL10 expression and API2-MALT1 gene rearrangement in ocular adnexal MALT lymphoma Peer-reviewed

    A Adachi, J Tamaru, K Kaneko, H Kuroda, Miura, I, T Kojima, S Hoshino, R Ichinohasama, S Itoyama

    PATHOLOGY INTERNATIONAL　54　(1)　16-25　2004/01

    DOI： 10.1111/j.1440-1827.2004.01580.x 　

    ISSN： 1320-5463

  100. 白板症,扁平苔癬の臨床診断と病理組織診断の不一致

    小野寺 健, 三田村 順子, 徐 輝, 熊本 裕行, 一迫 玲, 大家 清

    みちのく歯学会雑誌　34　(1〜2)　14-14　2003/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  101. Natural killer cell lymphoma of the parotid gland Peer-reviewed

    M Furukawa, H Suzuki, Y Tohmiya, K Matsuura, E Takahashi, R Ichinohasama, T Kobayashi

    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES　65　(4)　219-222　2003/07

    DOI： 10.1159/000073119 　

    ISSN： 0301-1569

  102. Should increasing the dose or adding an AT(1) receptor blocker follow a relatively low dose of ACE inhibitor initiated in acute myocardial infarction? Peer-reviewed

    T Sugie, Y Kagaya, M Takeda, H Yahagi, C Takahashi, J Takahashi, M Ninomiya, J Watanabe, R Ichinohasama, F Tezuka, K Shirato

    CARDIOVASCULAR RESEARCH　58　(3)　611-620　2003/06

    DOI： 10.1016/S0008-6363(03)00318-3 　

    ISSN： 0008-6363

  103. Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation Peer-reviewed

    S Scott, T Kimura, R Ichinohasama, S Bergen, A Magliocco, C Reimer, A Kerviche, D Sheridan, JF DeCoteau

    LEUKEMIA RESEARCH　27　(1)　23-34　2003/01

    DOI： 10.1016/S0145-2126(02)00078-4 　

    ISSN： 0145-2126

  104. レーザー照射が歯肉と辺縁性歯周炎に与える影響

    徐 輝, 小野寺 健, 熊本 裕行, 一迫 玲, 大家 清, 鈴木 孝裕, 清水 良央, 江澤 敏光

    みちのく歯学会雑誌　33　(1〜2)　54-55　2002/12

    Publisher: 東北地区歯科医学会

    ISSN： 0385-0099

  105. Oral Manifestations of Chronic Graft-versus-host Disease: A clinicopathological study Peer-reviewed

    Yoshida M, Kumamoto H, Sugawara Y, Ichinohasama R, Sasano T, Mayanagi H, Ooya K

    Oral Med Pathol　7　(2)　69-74　2002/12

    DOI： 10.3353/omp.7.69 　

  106. 慢性GVHDの口腔病変に関する臨床病理学的研究

    吉田 光秀, 菅原 由美子, 熊本 裕行, 一迫 玲, 笹野 高嗣, 真柳 秀昭, 大家 清

    日本口腔科学会雑誌　51　(6)　550-550　2002/11

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  107. 口腔疣贅性癌と扁平上皮癌のP53,MDM2,P14,P21蛋白発現からみた差異に関する免疫組織化学的研究

    井筒 崇司, 熊本 裕行, 一迫 玲, 大家 清, 越後 成志

    歯科基礎医学会雑誌　44　(5)　394-394　2002/09

    Publisher: (一社)歯科基礎医学会

    ISSN： 0385-0137

  108. T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction Peer-reviewed

    K Willenbrock, R Ichinohasama, ME Kadin, Miura, I, T Terui, K Meguro, O Fukuhara, JF DeCoteau, ML Hansmann

    LABORATORY INVESTIGATION　82　(9)　1103-1109　2002/09

    ISSN： 0023-6837

  109. 喀痰中に出現した悪性中皮腫の3例 Peer-reviewed

    高崎健司, 三浦弘守, 森谷卓也, 亀セツ子, 佐藤三枝子, 渡辺みか, 一迫玲, 笹野公伸

    日本臨床細胞学会雑誌　41　(Suppl.1)　240-240　2002/03

  110. Primary angiosarcoma of the chest wall: CT and MR findings Peer-reviewed

    Reiji Sugita, Mituo Takezawa, Rei Itinohasama

    Radiation Medicine - Medical Imaging and Radiation Oncology　20　(2)　101-103　2002

    ISSN： 0288-2043

  111. Genetic analysis of DNA microsatellite loci in salivary gland tumours: comparison with immunohistochemical detection of hMSH2 and p53 proteins. International-journal Peer-reviewed

    K Ohki, H Kumamoto, R Ichinohasama, M Suzuki, T Yamaguchi, S Echigo, K Motegi, K Ooya

    International journal of oral and maxillofacial surgery　30　(6)　538-44　2001/12

    DOI： 10.1054/ijom.2001.0161 　

    ISSN： 0901-5027

  112. 血液凝固系因子を用いたセルブロック作製(フィブリンクロット法)に関する検討 Peer-reviewed

    三浦弘守, 森谷卓也, 一迫玲, 望月静枝, 鍛治光司, 高崎健司, 井上紘子, 遠藤希之, 渡辺みか, 笹野公伸

    日本臨床細胞学会雑誌　40　(Suppl.2)　476-476　2001/09

    Publisher:

    ISSN： 0387-1193

  113. Chromogenic in situ hybridization analysis of HER-2/neu status in breast carcinoma: application in screening of patients for trastuzumab (Herceptin) therapy. Peer-reviewed

    Kumamoto H, Sasano H, Taniguchi T, Suzuki T, Moriya T, Ichinohasama R

    Pathol Int　51　(8)　579-584　2001/08

    DOI： 10.1046/j.1440-1827.2001.01255.x 　

    ISSN： 1320-5463

  114. Morphological spectrum of cyclin D1-positive mantle cell lymphoma: Study of 168 cases Peer-reviewed

    Y Yatabe, R Suzuki, Y Matsuno, K Tobinai, R Ichinohazama, J Tamaru, Y Mizoguchi, Y Hashimoto, M Yamaguchi, M Kojima, N Uike, M Okamoto, K Isoda, K Ichimura, Y Morishima, M Seto, T Suchi, S Nakamura

    PATHOLOGY INTERNATIONAL　51　(10)　747-761　2001

    DOI： 10.1046/j.1440-1827.2001.01277.x 　

    ISSN： 1320-5463

  115. Alveolar soft-part sarcoma of the cheek: report of a case with a review of the literature. International-journal Peer-reviewed

    K Kimi, K Onodera, H Kumamoto, R Ichinohasama, S Echigo, K Ooya

    International journal of oral and maxillofacial surgery　29　(5)　366-9　2000/10

    DOI： 10.1016/S0901-5027(00)80054-5 　

    ISSN： 0901-5027

  116. Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma Peer-reviewed

    Yatabe Y, Suzuki R, Tobinai K, Matsuno Y, Ichinohasama R, Okamoto M, Yamaguchi M, Tamaru J, Uike N, Hashimoto Y, Morishima Y, Suchi T, Seto M, Nakamura S

    Blood　95　(7)　2253-61　2000

  117. Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma. Peer-reviewed

    Osada M, Ishioka C, Ichinohasama R, Kadowaki I, Murakawa Y, Watanabe M, Kanamaru R, Ikawa S

    Anticancer Drug Des　14　(2)　107-114　1999/04

  118. Astrocytoma and B-cell lymphoma development in a man with a p53 germline mutation. Peer-reviewed

    Murakawa Y, Yokoyama A, Kato S, Yoshioka T, Ichinohasama R, Kumabe T, Yoshimoto T, Ishioka C, Kanamaru R

    Japanese journal of clinical oncology　28　(10)　631-637　1998/10

    DOI： 10.1093/jjco/28.10.631 　

    ISSN： 0368-2811

  119. Establishment of a novel cell line (TS-2) of pre-B acute lymphoblastic leukemia with a T(1;19) not involving the E2A gene Peer-reviewed

    Miyako Yoshinari, Masue Imaizumi, Mariko Eguchi, Masahito Ogasawara, Toshiaki Saito, Hoshiro Suzuki, Yoshitsugu Koizumi, Yan Cui, Atsushi Sato, Takako Saisho, Ryo Ichinohasama, Yoichi Matsubara, Nanao Kamada, Kazuie Iinuma

    Cancer Genetics and Cytogenetics　101　(2)　95-102　1998/03

    DOI： 10.1016/S0165-4608(97)00260-4 　

    ISSN： 0165-4608

  120. Translocation (3 ; 16)(q27 ; p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement

    ICHINOHASAMA R

    Cancer Genet Cytogenet　103　133-139　1998

    DOI： 10.1016/S0165-4608(97)00390-7 　

  121. Multiple organ failure associated with extensive metastatic calcification in a patient with an intermediate state of human T lymphotropic virus type I (HTLV-1) infection: Report of an autopsy case

    Hiroyuki Kumamoto, Ryo Ichinohasama, Takashi Sawai, Hiroshi Naganuma, Yotaro Furukawa, Naoki Akiu, Maki Kano, Kiyoshi Ooya

    Pathology International　48　(4)　313-318　1998

    DOI： 10.1111/j.1440-1827.1998.tb03912.x 　

    ISSN： 1320-5463

  122. A cutaneous agranular CD2- CD4+ CD56+ "lymphoma": report of two cases and review of the literature. Peer-reviewed

    Kameoka J, Ichinohasama R, Tanaka M, Miura I, Tomiya Y, Takahashi S, Yamada M, Ichikawa I, Kadowaki I, Sasaki O, Kimura J, Meguro K, Ooya K, Ito S

    Am J Clin Pathol　110　478-488　1998

  123. [p53 mutation does not determine prognosis in non-Hodgkin's lymphoma]. Peer-reviewed

    Osada M, Ishioka C, Murakawa Y, Ichinohasama R, Kanamaru R, Ikawa S

    Gan to kagaku ryoho. Cancer & chemotherapy　24　(4)　471-475　1997/02

    ISSN： 0385-0684

  124. Mutations of the Epstein-Barr virus LMP-1 oncogene in a 10-year-old Japanese girl with nasopharyngeal carcinoma Peer-reviewed

    Y Ohashi, M Minegishi, H Fujie, S Tsuchiya, R Ichinohazama, T Konno

    ACTA PAEDIATRICA　85　(11)　1376-1379　1996/11

    ISSN： 0803-5253

  125. Peripheral CD4^+CD8^-γδ T-cell lymphoma: a case report with multiparameter analysis.

    ICHINOHASAMA R.

    Hum Pathol　27　1370-1377　1996

    DOI： 10.1016/S0046-8177(96)90353-6 　

  126. Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis. Peer-reviewed

    Sato A, Imaizumi M, Noro T, Ichinohasama R, Saito T, Yoshinari M, Suwabe N, Suzuki H, Koizumi Y, Cui Y

    Leuk Res　19　(11)　811-815　1995/11

  127. HYDROA VACCINIFORME-LIKE LYMPHOMATOID PAPULOSIS IN A JAPANESE CHILD - A NEW SUBSET Peer-reviewed

    N TABATA, S AIBA, R ICHINOHAZAMA, K KIKUCHI, H AOYAMA, M WATANABE, H TAGAMI

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY　32　(2)　378-381　1995/02

    ISSN： 0190-9622

  128. Diagnostic pathology and 3-color flow cytometry on malignant lymphoma.

    Ichinohasama Ryo, Sawai Takashi, Nagura Hiroshi

    The journal of the Japanese Society of Lymphoreticular Tissue research　35　(3)　187-192　1995

    Publisher: The Japanese Society for Lymphoreticular Tissue Research

    DOI： 10.3960/jslrt1961.35.187 　

    ISSN： 0386-9725

  129. Detection of a 14;18 breakpoint cluster region in B-cell lymphomas by PCR methods

    T. Funato, A. Ohkawa, M. Chiba, T. Kano, A. Hoshino, T. Kawamura, T. Sasaki, R. Ichinohasama, T. Sawai

    Rinsho byori. The Japanese journal of clinical pathology　42　(9)　981-985　1994

    ISSN： 0047-1860

  130. [A case of monoblastic crisis of CML beginning with extramedullary tumor formation in a rib] Peer-reviewed

    Harigae H, Nomura J, Furuyama K, Shishido T, Okuda M, Sato A, Sugawara T, Endo K, Yoshinaga K, Ichinohasama R

    Rinsho Ketsueki　33　(6)　806-810　1992/06

    DOI： 10.11406/rinketsu.33.806 　

Show all ︎Show first 5

Misc. 99

  1. 急性腎障害を呈したメソトレキセート関連血管免疫芽球性T細胞リンパ腫の1例

    熊谷輝, 市川聡, 市川聡, 渡邉樹也, 木葉大地, 小野寺晃一, 沖津庸子, 小林匡洋, 阿部正理, 大西康, 藤島史喜, 一迫玲, 亀岡淳一, 石井智徳

    臨床血液　66　(4)　2025

    ISSN： 0485-1439

  2. 早期の同種造血幹細胞移植施行により救命し得たEBV陽性節性T/NK細胞リンパ腫の1例

    市川聡, 市川聡, 安部宇明, 諸田直哉, 川尻昭寿, 中川諒, 猪倉恭子, 八田俊介, 勝岡優奈, 小野寺晃一, 福原規子, 大西康, 横山寿行, 横山寿行, 一迫玲, 張替秀郎

    臨床血液　65　(12)　2024

    ISSN： 0485-1439

  3. Peritoneal lymphomatosisによって腹部コンパートメント症候群を来したB細胞性リンパ腫の1例

    田中 悠也, 小野寺 晃一, 木葉 大地, 諸田 直哉, 道又 大吾, 小野 浩弥, 猪倉 恭子, 市川 聡, 福原 規子, 大西 康, 横山 寿行, 一迫 玲, 張替 秀郎

    臨床血液　63　(5)　491-492　2022/05

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  4. Clinicopathological features of B-cell lymphoma with three-way chromosomal translocation

    渡邊正太郎, 市川聡, 福原規子, 櫻井一貴, 橋本和貴, 古川瑛次郎, 道又大吾, 猪倉恭子, 小野寺晃一, 大西康, 横山寿行, 斎藤陽, 八田俊介, 鎌田真弓, 大橋圭一, 中嶌真治, 菅原知広, 藤島史喜, 一迫玲, 張替秀郎

    日本血液学会学術集会抄録(Web)　83rd　2021

  5. Four cases with discordant development of follicular and classic Hodgkin lymphoma

    阿部未玲, 阿部未玲, 福原規子, 市川聡, 櫻井一貴, 橋本和貴, 道又大吾, 古川瑛次郎, 渡邊正太郎, 猪倉恭子, 小野寺晃一, 大西康, 横山寿行, 藤島史喜, 一迫玲, 張替秀郎

    日本血液学会学術集会抄録(Web)　83rd　2021

  6. 抗tocilizumab抗体を検出しrituximabが奏功したTAFRO症候群

    渡邉真威, 勝岡優奈, 横山寿行, 伊藤俊広, 一迫玲

    仙台医療センター医学雑誌(Web)　11　(1)　2021

    ISSN： 2186-3946

  7. 末梢性T細胞リンパ腫/非特異型の分子病態による分類 免疫組織化学での応用も見据えて

    齋藤 慧, 藤島 史喜, 福原 規子, 張替 秀郎, 一迫 玲

    血液内科　81　(1)　107-113　2020/07

    Publisher: (有)科学評論社

    ISSN： 2185-582X

  8. 【血液疾患と消化器系の異常】原発性十二指腸・小腸リンパ腫の病態と治療

    市川 聡, 福原 規子, 一迫 玲

    血液内科　80　(6)　835-841　2020/06

    Publisher: (有)科学評論社

    ISSN： 2185-582X

  9. 【血液疾患と消化器系の異常】原発性十二指腸・小腸リンパ腫の病態と治療

    市川 聡, 福原 規子, 一迫 玲

    血液内科　80　(6)　835-841　2020/06

    Publisher: (有)科学評論社

    ISSN： 2185-582X

  10. 部分的自然寛解が得られたblastic plasmacytoid dendritic cell neoplasm(BPDCN)の1例

    鈴木 紅音, 阿部 正理, 小林 匡洋, 野村 順, 武田 智樹, 堤 智美, 岡 友美子, 城田 祐子, 小寺 隆雄, 亀岡 淳一, 沖津 庸子, 高橋 伸一郎, 長尾 宗紀, 鈴木 清寿, 児山 香, 一迫 玲

    臨床血液　61　(4)　418-419　2020/04

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  11. 血管免疫芽球性T細胞リンパ腫の経過中に発症したEBウイルス陽性末梢性T細胞リンパ腫,非特定型

    渡邉真威, 勝岡優奈, 横山寿行, 伊藤俊広, 中村直哉, 一迫玲

    仙台医療センター医学雑誌(Web)　10　(3)　2020

    ISSN： 2186-3946

  12. 宮城県におけるびまん性大細胞型B細胞リンパ腫を合併した濾胞性リンパ腫の予後

    渡邊正太郎, 福原規子, 横山寿行, 小野寺晃一, 市川聡, 大西康, 勝岡優奈, 八田俊介, 齋藤慧, 佐々木治, 原崎頼子, 鎌田真弓, 遠宮靖雄, 一迫玲, 張替秀郎

    日本血液学会学術集会抄録(Web)　82nd　2020

  13. 無顆粒球症を呈した成熟γδT細胞白血病の一例

    市川聡, 齋藤慧, 福原規子, 横山寿行, 田中悠也, 李尹河, 小野寺晃一, 大西康, 藤原亨, 藤島史喜, 一迫玲, 張替秀郎

    日本血液学会学術集会抄録(Web)　82nd　2020

  14. 免疫抑制療法中に濾胞性リンパ腫と古典的ホジキンリンパ腫を合併した2例

    渡邊 正太郎, 福原 規子, 古川 瑛次郎, 佐野 沙矢香, 齋藤 慧, 市川 聡, 大西 康, 中村 直哉, 一迫 玲, 張替 秀郎

    日本リンパ網内系学会会誌　59　134-134　2019/05

    Publisher: (一社)日本リンパ網内系学会

    ISSN： 1342-9248

    eISSN： 1883-681X

  15. 免疫抑制療法中に濾胞性リンパ腫と古典的ホジキンリンパ腫を合併した2例

    渡邊 正太郎, 福原 規子, 古川 瑛次郎, 佐野 沙矢香, 齋藤 慧, 市川 聡, 大西 康, 中村 直哉, 一迫 玲, 張替 秀郎

    日本リンパ網内系学会会誌　59　134-134　2019/05

    Publisher: (一社)日本リンパ網内系学会

    ISSN： 1342-9248

  16. CD56陽性皮膚T細胞リンパ腫6例の後方視的解析(A clinicopathological analysis of CD56-positive cutaneous T cell lymphoma)

    大地 哲朗, 福原 規子, 佐野 沙矢香, 那須 健太郎, 小林 匡洋, 市川 聡, 沖津 庸子, 大西 康, 藤原 実名美, 藤村 卓, 一迫 玲, 張替 秀郎

    臨床血液　59　(9)　1549-1549　2018/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  17. びまん性大細胞型B細胞リンパ腫におけるsIL-2R値の層別化予後因子としての意義(Serum sIL-2R level is a prognostic stratification marker of diffuse large B-cell lymphoma)

    市川 聡, 福原 規子, 小林 匡洋, 沖津 庸子, 大西 康, 一迫 玲, 石澤 賢一, 張替 秀郎

    臨床血液　59　(9)　1785-1785　2018/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  18. CD56陽性皮膚T細胞リンパ腫6例の後方視的解析(A clinicopathological analysis of CD56-positive cutaneous T cell lymphoma)

    大地 哲朗, 福原 規子, 佐野 沙矢香, 那須 健太郎, 小林 匡洋, 市川 聡, 沖津 庸子, 大西 康, 藤原 実名美, 藤村 卓, 一迫 玲, 張替 秀郎

    臨床血液　59　(9)　1549-1549　2018/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  19. DLBCLsにおける免疫組織化学の表記法とMYC遺伝子転座有無に関する研究

    藤島 史喜, 臼渕 肇, 北脇 優子, 佐藤 聡子, 笹野 公伸, 一迫 玲

    日本病理学会会誌　107　(1)　402-402　2018/04

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  20. サルコイド反応を伴う末梢性T細胞リンパ腫の1例

    中嶋 夏磯, 水芦 政人, 佐々木 留伊, 大竹 映香, 遠野 久幸, 日高 高徳, 神林 由美, 岡田 修子, 相場 節也, 市川 聡, 福原 規子, 一迫 玲, 村井 孝弥

    日本皮膚科学会雑誌　127　(10)　2341-2341　2017/09

    Publisher: (公社)日本皮膚科学会

    ISSN： 0021-499X

  21. 多彩な組織像を呈した生体肝移植後のPost-transplant lymphoproliferative disorderの一例

    熊田 博之, 中西 史, 村上 圭吾, 宮城 重人, 原 康之, 一迫 玲, 川岸 直樹, 笹野 公伸, 大内 憲明, 里見 進

    移植　52　(2-3)　236-236　2017/09

    Publisher: (一社)日本移植学会

    ISSN： 0578-7947

    eISSN： 2188-0034

  22. 【造血器・リンパ系腫瘍のWHO分類 2016 version】リンパ系腫瘍 成熟B細胞腫瘍 慢性リンパ性白血病/小リンパ球性リンパ腫,濾胞性リンパ腫,マントル細胞リンパ腫(解説/特集)

    市川 聡, 福原 規子, 一迫 玲, 張替 秀郎

    医学書院　61　(7)　836-840　2017/07

    Publisher: 医学書院

    DOI： 10.11477/mf.1542201320 　

    ISSN： 0485-1420

  23. Immunophenotype and normal counterpart of peripheral T-cell lymphoma

    74　(6)　791-797　2017/06

    Publisher: 科学評論社

    ISSN： 2185-582X

  24. 脳病変を伴った皮膚原発CD8陽性劇症型表皮向性細胞障害性T細胞リンパ腫に対して臍帯血移植を施行した1例

    市川 聡, 福原 規子, 八田 俊介, 氷室 真仁, 那須 健太郎, 小野 浩弥, 渡邉 真威, 猪倉 恭子, 小林 匡洋, 大西 康, 石澤 賢一, 一迫 玲, 張替 秀郎

    臨床血液　58　(4)　403-403　2017/04

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  25. 宮城県において5年間に消化管で診断された悪性リンパ腫の検討

    藤島 史喜, 勝嶌 浩紀, 深谷 佐智子, 笠島 敦子, 中村 保宏, 谷内 真司, 佐藤 聡子, 渡辺 みか, 一迫 玲, 笹野 公伸

    日本病理学会会誌　105　(1)　497-497　2016/04

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  26. T-LBLに対する骨髄移植後に発症した大脳限局リンパ増殖性疾患(DLBCL)の一剖検例

    小谷 健太郎, 勝嶌 浩紀, 村上 圭吾, 大西 康, 藤島 史喜, 北本 哲之, 張替 秀郎, 笹野 公伸, 一迫 玲

    日本病理学会会誌　105　(1)　583-583　2016/04

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  27. Leukocytosisを呈しBRAF V600E変異陽性のhairy cell leukemia-variantの1例

    金美賢, 高橋太郎, 市川聡, 市川聡, 小野寺晃一, 坂元和宏, 一迫玲

    臨床血液　57　(4)　2016

    ISSN： 0485-1439

  28. Impaired Lysophosphatidic Acid Receptor 3 Signaling in Mesenchymal Stromal Cells Promotes Multiple Myeloma Progression through Cellular Senescence and Transdifferentiation into Tumor-Associated Fibroblasts

    Masahiko Kanehira, Tohru Fujiwara, Shinji Nakajima, Yoko Okitsu, Yasushi Ohnishi, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    BLOOD　126　(23)　2015/12

    ISSN： 0006-4971

    eISSN： 1528-0020

  29. 骨髄間質細胞におけるリゾホスファチジン酸受容体シグナルは多発性骨髄腫の進展を制御する

    兼平 雅彦, 福原 規子, 一迫 玲, 張替 秀郎

    日本癌学会総会記事　74回　P-2264　2015/10

    Publisher: 日本癌学会

    ISSN： 0546-0476

  30. THE SIGNALING BALANCE BETWEEN LYSOPHOSPHATIDIC ACID RECEPTOR 1 AND 3 IN BONE MARROW-DERIVED MESENCHYMAL STEM CELLS DETERMINES PROGRESSION OF MULTIPLE MYELOMA

    Masahiko Kanehira, Tohru Fujiwara, Shinji Nakajima, Yoko Okitsu, Yasushi Onishi, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

    EXPERIMENTAL HEMATOLOGY　43　(9)　S71-S71　2015/09

    ISSN： 0301-472X

    eISSN： 1873-2399

  31. Mantle cell lymphomaとperipheral T-cell lymphomaが同一リンパ節内に認められたcomposite lymphomaの一例

    勝嶌 浩紀, 中嶌 真治, 高川 真徳, 福原 規子, 板倉 裕子, 高橋 徹, 笹野 公伸, 一迫 玲

    日本病理学会会誌　104　(1)　366-366　2015/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  32. Exploring the Potential Usefulness of 5-Aminolevulinic Acid for X-Linked Sideroblastic Anemia

    Tohru Fujiwara, Ryoyu Niikuni, Koji Okamoto, Yoko Okitsu, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ryo Ichinohasama, Yukio Nakamura, Tohru Tanaka, Hideo Harigae

    BLOOD　124　(21)　2014/12

    ISSN： 0006-4971

    eISSN： 1528-0020

  33. 消化管悪性リンパ腫疑い症例に対する多角的解析の検討

    藤島 史喜, 一迫 玲, 笠島 敦子, 中村 保宏, 谷内 真司, 柴原 裕紀子, 佐藤 聡子, 齋藤 涼子, 佐藤 直実, 深谷 佐智子, 板倉 裕子, 前川 尚志, 勝嶌 浩紀, 渡辺 みか, 笹野 公伸

    日本病理学会会誌　103　(1)　293-293　2014/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  34. 骨髄生検でB-リンパ芽球性白血病/リンパ腫と濾胞性リンパ腫が同時に認められた一例

    勝嶌 浩紀, 大田 泰徳, 沖津 庸子, 福原 規子, 張替 秀郎, 笹野 公伸, 一迫 玲

    日本病理学会会誌　103　(1)　371-371　2014/03

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  35. Weber-Christian病として治療中にsubcutaneous panniculitis-like T cell lymphomaが出現した一例

    勝嶌 浩紀, 谷内 真司, 藤井 博司, 張替 秀郎, 笹野 公伸, 一迫 玲

    日本リンパ網内系学会会誌　53　150-150　2013

  36. Regulation of Erythropoiesis by Histone Methyltransferase EZH2 Inhibitor 3-Deazaneplanocin A (DZNep)

    Tohru Fujiwara, Haruka Saitoh, Yoko Okitsu, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ryo Ichinohasama, Hideo Harigae

    BLOOD　120　(21)　2012/11

    ISSN： 0006-4971

  37. 若年成人における節外性NK/T細胞性リンパ腫の臨床病理学的解析 MIYAGI試験(A clinicopathological analysis of extranodal NK/T-cell lymphoma in younger adults: MIYAGI study)

    Fukuhara Noriko, Ichikawa Satoshi, Suzuki Makiko, Nakajima Shinji, Okitsu Yoko, Katsuoka Yuna, Kohata Katsura, Fujiwara Tohru, Onishi Yasushi, Yamamoto Joji, Yokoyama Hisayuki, Fujiwara Minami, Meguro Kuniaki, Takahashi Taro, Ishikawa Izumi, Ishizawa Kenichi, Kameoka Junichi, Ichinohasama Ryo, Harigae Hideo

    臨床血液　53　(9)　1163-1163　2012/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  38. 剖検により診断された血管内大細胞型B細胞リンパ腫(IVL)の1例

    佐藤 聡子, 深谷 佐智子, 佐藤 直実, 谷内 真司, 柴原 裕紀子, 笠島 敦子, 中村 保宏, 藤島 史喜, 渡辺 みか, 一迫 玲, 笹野 公伸

    日本病理学会会誌　101　(2)　65-65　2012/09

    Publisher: (一社)日本病理学会

    ISSN： 0300-9181

  39. マントル細胞リンパ腫長期生存例の後方視的解析

    福原規子, 原崎頼子, 井根省二, 遠宮靖雄, 奥田光崇, 三浦由希子, 大口裕人, 大西康, 木幡桂, 横山寿行, 石澤賢一, 亀岡淳一, 一迫玲, 佐々木治, 張替秀郎

    日本臨床腫瘍学会学術集会プログラム・抄録集　9th　2011

  40. 腸症型T細胞リンパ腫 MIYAGI研究会による臨床病理学的解析(Enteropathy-associated T-cell lymphoma: a clinicopathoiogical analysis from MIYAGI study group)

    Fukuhara Noriko, Kamata Mayumi, Yamamoto Joji, Yokoyama Hisayuki, Takahashi Taro, Ishikawa Izumi, Sugawara Tomohiro, Takagawa Masanori, Sasaki Osamu, Katsuoka Yuna, Miura Yukiko, Ohba Rie, Okitsu Yoko, Kohata Katsura, Ohguchi Hiroto, Onishi Yasushi, Ishizawa Kenichi, Kameoka Junichi, Ichinohasama Ryo, Harigae Hideo

    臨床血液　51　(9)　983-983　2010/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  41. Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma

    CHUANG Shih-Sung, ICHINOHASAMA Ryo, CHU Jan-Show, OHSHIMA Koichi

    Int J Hematol　91　(4)　687-691　2010/05/21

    ISSN： 0925-5710

  42. Multicentric primary intestinal EBV-positive diffuse large B cell lymphoma of the elderly presenting with perforation

    CHUANG Shih-Sung, ICHINOHASAMA Ryo, YANG Chun-Chieh, WANG Wen-Ching, CHOU Chung-Kuao, LIAO Yung-Liang, KUO Szu-Yin, LIN Shu-Hui

    91　(3)　534-538　2010/04/15

    ISSN： 0925-5710

  43. A case of intravascular large B-cell lymphoma of the cutaneous variant : the first case in Asia

    KAMEOKA Yoshihiro, TAKAHASHI Naoto, TAGAWA Hiroyuki, FUJISHIMA Naohito, YOSHIOKA Tomoko, SAITO Hirofumi, HIROKAWA Makoto, ICHINOHASAMA Ryo, SAWADA Kenichi

    Int J Hematol　91　(1)　146-148　2010/01/15

    ISSN： 0925-5710

  44. 宮城県における悪性リンパ腫の臨床および病理学的特徴

    三浦 由希子, 鎌田 真弓, 小林 匡洋, 中嶌 真治, 市川 聡, 鈴木 真紀子, 井上 あい, 沖津 庸子, 大口 裕人, 福原 規子, 木幡 桂, 大西 康, 山本 譲司, 横山 寿行, 石澤 賢一, 亀岡 淳一, 一迫 玲, 張替 秀郎

    臨床血液　50　(9)　1026-1026　2009/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  45. FISH法によるIgH転座解析を用いた濾胞性リンパ腫骨髄浸潤の検出

    木幡 桂, 三浦 由希子, 大口 裕人, 沖津 庸子, 福原 規子, 大西 康, 山本 譲司, 石澤 賢一, 亀岡 淳一, 張替 秀郎, 横山 寿行, 一迫 玲, 安 久美子, 賀来 満夫

    臨床血液　50　(9)　1043-1043　2009/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  46. Flow cytometry for diagnosis of T-cell lymphoma

    58　(6)　640-648　2009/06

    Publisher: 科学評論社

    ISSN： 0915-8529

  47. 臨床的にDiGeorge症候群が疑われたEBV陽性T細胞性悪性リンパ腫の1剖検例 (日本病理学会会誌)

    伊藤しげみ, 三木康宏, 笹野公伸, 一迫玲

    日本病理学会会誌　98　(1)　273-273　2009/03

  48. Kidney-limited intravascular large B cell lymphoma: a distinct variant of IVLBCL?

    Kameoka Y, Takahashi N, Komatsuda A, Tagawa H, Hamai K, Hirokawa M, Wakui H, Ichinohasama R, Sawada K

    International Journal of Hematology ,　89　(4)　533-537　2009

    DOI： 10.1007/s12185-009-0294-5 　

    ISSN： 0925-5710

    More details Close

    ,2009

  49. 副腎偶発腫瘍の鑑別診断 副腎原発非ホジキンリンパ腫の診断

    森本 玲, 山田 友里恵, 佐藤 文俊, 工藤 正孝, 村上 治, 石澤 賢一, 張替 秀郎, 石岡 千加史, 高橋 昭喜, 石戸谷 滋人, 荒井 陽一, 一迫 玲, 伊藤 貞嘉

    日本内分泌学会雑誌　84　(3)　895-895　2008/12

    Publisher: (一社)日本内分泌学会

    ISSN： 0029-0661

  50. De novo CD5陽性びまん性大細胞型B細胞リンパ腫 120例における詳細な臨床病理学的検討の結果

    山口 素子, 中村 直哉, 鈴木 律朗, 鏡味 良豊, 岡本 昌隆, 一迫 玲, 吉野 正, 鈴宮 淳司, 村瀬 卓平, 三浦 偉久男, 大島 孝一, 錦織 桃子, 田丸 淳一, 谷脇 雅史, 平野 正美, 森島 泰雄, 上田 龍三, 珠玖 洋, 中村 栄男

    臨床血液　49　(9)　861-861　2008/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  51. 濾胞性リンパ腫における転写抑制因子BACH2の発現(Expression of BACH2, a transcription repressor, in follicular lymphoma)

    山本 譲司, 石澤 賢一, 五十嵐 和彦, 一迫 玲, 張替 秀郎

    日本癌学会総会記事　67回　317-317　2008/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  52. Rapidly growing cobblestone-like nodules as a manifestation of myeloid sarcoma.

    Nakagawa Satoshi, Tagami Hachiro, Ichinohasama Ryo, Aiba Setsuya

    Acta Derm Venereol　88　(6)　633-634　2008

    DOI： 10.2340/00015555-0521 　

  53. HHV-8/KSHV-Negative and CD20-Positive Primary Effusion Lymphoma Successfully Treated by Pleural Drainage Followed by Chemotherapy Containing Rituximab

    Terasaki Yasushi, Okumura Hirokazu, Saito Katsuhiko, Sato Yasuharu, Yoshino Tadashi, Ichinohasama Ryo, Ishida Youichi

    Japanese Journal of Medicine　47　(24)　2175-2178　2008

    Publisher: The Japanese Society of Internal Medicine

    DOI： 10.2169/internalmedicine.47.1565 　

    ISSN： 0918-2918

    More details Close

    The present patient was diagnosed as having human herpes virus-8 (HHV-8)/Kaposi sarcoma herpes virus (KSHV)-negative and CD20-positive primary effusion lymphoma (PEL) of the right-sided pleural effusion. After pleural drainage, malignant cells disappeared spontaneously in a small amount of the remaining pleural effusion without chemotherapy. The patient was treated with six cycles of chemotherapy consisting of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone. He has been in complete remission for more than 22 months. It is suggested that effusion drainage followed by chemotherapy containing rituximab is a potential treatment strategy for patients with HHV-8/KSHV-negative and CD20-positive PEL.<br>

  54. De novo CD5(+) diffuse large B-cell lymphoma: Result of a detail morphologic evaluation and long-term follow up of 128 patients

    Motoko Yamaguchi, Naoya Nakamura, Ritsuro Suzuki, Yoshitoyo Kagami, Masataka Okamoto, Ryo Ichinohasama, Tadashi Yoshimo, Junji Suzumiya, Takuhei Murase, Ikuo Miura, Masami Hirano, Yasuo Morishima, Hiroshi Shiku, Ryuzo Ueda, Shigeo Nakamura

    BLOOD　110　(11)　467A-468A　2007/11

    ISSN： 0006-4971

  55. Hodgkin-like anaplastic large cell lymphoma (previously designated in the REAL classification) has same immunophenotypic features to classical Hodgkin lymphoma.

    Tamaru J, Tokuhira M, Nittsu N, Nakamura S, Ichinohasama R, Suzuki R, Mori H, Takagi T, Suzuki T, Itami J, Itoyama S, Mikata A

    48　(6)　1127-38　2007/06

    DOI： 10.1080/10428190701342000 　

  56. 多角的解析が悪性リンパ腫との鑑別に有用であった小腸リンパ増殖性疾患の3例

    野村栄樹, 高木承, 一迫玲, 根来健一, 高橋成一, 木内喜孝, 下瀬川徹

    栄養-評価と治療　24　(2)　173-173　2007

    Publisher: (株)メディカルレビュー社

    ISSN： 0915-759X

  57. CD26, together with cell surface adenosine deaminase, is selectively expressed on ALK-positive, but not on ALK-negative, anaplastic large cell lymphoma and Hodgkin's lymphoma

    Junichi Kameoka, Ryo Ichinohasama, Hiroko Inoue, Joji Yamamoto, Hisayuki Yokoyama, Yasuo Tomiya, Minami Yamada, Kenichi Ishizawa, Hideo Harigae, Takashi Sawai, Takeshi Sasaki

    Leukemia and Lymphoma　47　(10)　2181-8　2006

    DOI： 10.1080/10428190600773396 　

    ISSN： 1042-8194

    eISSN： 1029-2403

  58. 悪性リンパ腫におけるリンパ管新生についての検討

    門脇育子, 一迫玲, 張替秀郎, 石澤賢一, 沖津庸子, 高橋伸一郎, 亀岡淳一, 佐々木毅, 賀来満夫

    臨床病理　54　(補冊)　259-259　2006

  59. Lymphoepithelioma-like carcinoma of the breast. Report of a case with the first electron microscopic study and review of the literature

    A Kurose, R Ichinohasama, H Kanno, T Kobayashi, M Ishida, N Nishinari, T Sawai

    VIRCHOWS ARCHIV　447　(3)　653-659　2005/09

    DOI： 10.1007/s00428-004-1195-x 　

    ISSN： 0945-6317

  60. Fluorescence In Situ Hybridization Monitoring of BCR-ABL-Positive Neutrophils in Chronic-Phase Chronic Myeloid Leukemia Patients during the Primary Stage of Imatinib Mesylate Therapy

    TAKAHASHI Naoto, MIURA Ikuo, KOBAYASHI Yoshimi, KUME Masaaki, YOSHIOKA Tomoko, OTANE Wataru, OHTSUBO Kaori, TAKAHASHI Kaoru, KITABAYASHI Atsushi, KAWABATA Yoshinari, HIROKAWA Makoto, NISHIJIMA Hirokazu, ICHINOHASAMA Ryo, DECOTEAU John, MIURA Akira B., SAWADA Ken-ichi

    Int J Hematol.　81　(3)　235-241　2005/04/15

    ISSN： 0925-5710

  61. 悪性リンパ腫におけるリンパ管新生についての検討

    門脇育子, 一迫玲, 張替秀郎, 石沢賢一, 沖津庸子, 山本譲司, 横山寿行, 遠宮靖雄, 藤原実名美, 亀岡淳一, 佐々木毅

    臨床血液　46　(8)　2005

    ISSN： 0485-1439

  62. A Case Report of Multiple Perforations of Transverse Colon Induced by a Non-steroidal Anti-inflammatory Drug (Diclofenac Sodium)

    Sato Koichiro, Sagawa Junji, Ichinohasama Ryo, Kumamoto Hiroyuki, Yamaguchi Masato

    The Japanese journal of gastroenterological surgery　37　(9)　1582-1587　2004/09/01

    Publisher: The Japanese Society of Gastroenterological Surgery

    ISSN： 0386-9768

    More details Close

    We report a case of multiple perforations of the transverse colon induced by a nonsteroidal antiinflammatory drug (NSAID). which is quite rare in Japan. A 31-year-old man admitted for chronic tonsillitis was administered 75-112.5 mg/day of diclofenac sodium tablets and 50-100 mg/day of suppository as painkiller after tonsillectomy. Thirteen days postoperatively, he suffered sudden severe epigastralgia. Abdominal computed tomography showed free air and ascites in the abdominal cavity, leading to a diagnosis of panperitonitis caused by gastrointestinal tract perforation, necessitating emergency surgery. Multiple perforations at the transverse colon necessitated partial transverse and ascending colectomy. Histological findings showed that multiple perforated ulcers with necrosis masses and fibrin at the transverse colon, presumed to be nonspecific inflammatory findings. He recovered well, and was discharged on postoperative day 22.

  63. 同種骨髄移植を施行した節外性NK細胞リンパ腫の1例

    大口 裕人, 亀岡 淳一, 沖津 庸子, 小林 美津恵, 横山 寿行, 遠宮 靖雄, 山田 実名美, 石澤 賢一, 佐々木 毅, 高橋 伸一郎, 張替 秀郎, 一迫 玲

    臨床血液　45　(9)　1073-1074　2004/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

  64. Abscopal effect of small intestinal NK/T-cell lymphoma

    HORIUHI Takahiro, NOMURA Jun, OKUDA Mitsutaka, ICHINOHASAMA Ryo

    Rinsho Ketsueki　44　(9)　940-945　2003/09/30

    Publisher: 日本臨床血液学会

    ISSN： 0485-1439

  65. FISH法を用いた悪性リンパ腫の骨髄浸潤の検出

    石澤賢一, 張替秀郎, 小原保彦, 亀岡淳一, 宮村耕一, 一迫玲, 賀来満夫, 佐々木毅

    臨床血液　44　(8)　717-717　2003

  66. De novo CD5(+) diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients.

    Yamaguchi M, Seto M, Okamoto M, Ichinohasama R, Nakamura N, Yoshino T, Suzumiya J, Murase T, Miura I, Akasaka T, Tamaru Ji J, Suzuki R, Kagami Y, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S

    Blood　2002

    DOI： 10.1182/blood.V99.3.815 　

  67. Primary marginal zone lymphoma of the thymus accompanied by chromosomal anomaly 46,X,dup(X)(p11p22).

    Harigae Hideo, Ichinohasama Ryo, Miura Ikuo, Kameoka Junichi, Meguro Kuniaki, Miyamura Koichi, Sasaki Osamu, Ishikawa Izumi, Takahashi Shin-ichiro, Kaku Mitsuo, Sasaki Takeshi

    Cancer Genet Cytogenet　133　(2)　142-147　2002

    DOI： 10.1016/S0165-4608(01)00568-4 　

  68. B細胞性リンパ腫の表面マーカーの解析

    石澤 賢一, 一迫 玲, 田丸 淳一, 臼渕 規子, 衣斐 寛倫, 河田 健司, 田原 信, 南 博信, 五十嵐 忠彦, 伊藤 国明

    臨床血液　42　(10)　1007-1007　2001/10

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  69. 学外病理組織顕微鏡検査(1991-2000)の舌白色病変に関する臨床病理学的検討

    徐輝, 小野寺健, 熊本裕行, 一迫玲, 大家清, 吉田光秀, 清水良央

    みちのく齒學會雑誌　32　(1-2)　2001

    ISSN： 0385-0099

  70. <講演抄録>7.エナメル上皮腫と歯原性明細胞腫におけるインテグリン, CD44の発現に関する免疫組織化学的研究(第37回東北大学歯学会講演抄録)(一般演題)

    大庭 伸介, 鈴木 孝祐, 熊本 裕行, 一迫 玲, 大家 清

    東北大学歯学雑誌 = Tohoku University dental journal　19　(2)　193-193　2000/12/01

    ISSN： 0287-3915

  71. Prognostic significance of CD5 expression in diffuse large B-cell lymphomas.

    M Yamaguchi, M Seto, Y Morishima, R Ichinohasama, M Okamoto, N Nakamura, T Yoshino, J Suzumiya, R Ueda, S Nakamura

    BLOOD　96　(11)　506A-506A　2000/11

    ISSN： 0006-4971

  72. The World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities

    M Fujita, K Yamashiro, R Ichinohasama, N Nakamura, M Abe, H Wakasa, M Kojima, T Motoori, T Izumo, J Tamaru, A Mikata, K Takeuchi, C Kakiuchi, S Mori, Y Matsuno, S Nakamura, Y Yatabe, K Ichimura, T Suchi, K Tajima, N Mori, K Takasaki, K Tsurumi, T Takami, H Haga, T Sakurai, H Yamabe, Y Kobashi, M Ohsawa, H Kanno, K Aozasa, H Nakamine, T Yoshino, T Akagi, N Sasaki, K Namba, Y Agatsuma, K Iwata, J Suzumiya, K Ohshima, M Kikuchi, M Takeshita, K Hasui, E Sato, K Sueyoshi, M Tokunaga

    PATHOLOGY INTERNATIONAL　50　(9)　696-702　2000/09

    DOI： 10.1046/j.1440-1827.2000.01108.x 　

    ISSN： 1320-5463

    eISSN： 1440-1827

  73. Extramedullary lymphoproliferative disorders in a patient with Ph-positive chronic myelogenous leukemia

    ICHINOHASAMA Ryo

    41　(4)　280-282　2000/04/30

    Publisher: 日本臨床血液学会

    ISSN： 0485-1439

  74. 初発時節性リンパ芽球性リンパ腫と診断せざるを得なかった急性骨髄単球性白血病の1例

    山田 実名美, 佐々木 治, 横山 寿行, 石川 泉, 亀岡 淳一, 目黒 邦昭, 佐々木 毅, 一迫 玲

    International Journal of Hematology　71　(Suppl.1)　69-69　2000/04

    Publisher: (一社)日本血液学会

    ISSN： 0925-5710

    eISSN： 1865-3774

  75. The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma

    Y Hosokawa, Y Maeda, R Ichinohasama, Miura, I, M Taniwaki, M Seto

    BLOOD　95　(8)　2719-2721　2000/04

    ISSN： 0006-4971

  76. Peripheral T-cell lymphoma with distinct perifollicular growth pattern - A distinct subtype of T-cell lymphoma?

    T Rudiger, R Ichinohasama, MM Ott, S Muller-Deubert, Miura, I, G Ott, HK Muller-Hermelink

    AMERICAN JOURNAL OF SURGICAL PATHOLOGY　24　(1)　117-122　2000/01

    DOI： 10.1097/00000478-200001000-00014 　

    ISSN： 0147-5185

  77. 初発時節性リンパ芽球性リンパ腫と診断せざるを得なかった急性骨髄単球性白血病の一例

    山田実名美, 佐々木治, 横山寿行, 石川泉, 亀岡淳一, 目黒邦昭, 佐々木毅, 一迫玲

    International Journal of Hematology. Supplement　71　(1)　2000

    ISSN： 0917-1258

  78. Ph-negative non-Hodgkin's lymphoma occurring in chronic phase of Ph-positive chronic myelogenous leukemia is defined as a genetically different neoplasm from extramedullary localized blast crisis : report of two cases and review of the literature

    ICHINOHASAMA R.

    Leukemia　14　169-182　2000

  79. Detection of t(14;18)(q32;q21) in hyperdiploid cells by fluorescence in situ hybridization in a patient with Hodgkin disease.

    Miura I, Tamura A, Taniwaki M, Nakamura S, Nakamine H, Yoshino T, Ichinohasama R, Miura AB

    Cancer Genet Cytogenet.　2000

    DOI： 10.1016/S0165-4608(00)00311-3 　

  80. Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype.

    Suzuki R, Kagami Y, Takeuchi K, Kami M, Okamoto M, Ichinohasama R, Mori N, Kojima M, Yoshino T, Yamabe H, Shiota M, Mori S, Ogura M, Hamajima N, Seto M, Suchi T, Morishima Y, Nakamura S

    Blood　2000

  81. Analysis of the PTEN gene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients.

    Negoro K, Takahashi S, Kinouchi Y, Takagi S, Hiwatashi N, Ichinohasama R, Shimosegawa T, Toyota T

    Dis Colon Rectum　43　(10 Suppl)　S29-33　2000

  82. <講演抄録>7.唾液腺腫瘍における遺伝子異常の解析(第35回東北大学歯学会講演抄録)(一般演題) : マイクロサテライト領域のPSR解析と免疫組織化学的所見の比較

    大木 宏介, 熊本 裕行, 一迫 玲, 大家 清, 茂木 克俊, 越後 成志, 笹野 高嗣

    東北大学歯学雑誌 = Tohoku University dental journal　18　(2)　191-191　1999/12/01

    ISSN： 0287-3915

  83. Hepatosplenic αβ T cell lymphomaと考えられる1例

    山田 実名美, 亀岡 淳一, 横山 寿行, 木村 朋文, 遠宮 靖雄, 石川 泉, 佐々木 治, 目黒 邦昭, 佐々木 毅, 一迫 玲

    臨床血液　40　(9)　966-966　1999/09

    Publisher: (一社)日本血液学会-東京事務局

    ISSN： 0485-1439

    eISSN： 1882-0824

  84. 【胃MALTリンパ腫 Helicobacter pylori除菌後の経過】 胃MALTリンパ腫のHelicobacter pylori除菌後の経過 内視鏡像・病理組織像と治療後の変化 (胃と腸)

    鈴木達彦, 加藤勝章, 一迫玲, 大楽尚弘, 久保田祐司, 相田重光, 今野豊, 及川圭介, 野口謙治, 小池智幸, 今谷晃, 杉山幸一, 関根仁, 大原秀一, 下瀬川徹, 豊田隆謙

    胃と腸　34　(11)　1367-1379　1999

    DOI： 10.11477/mf.1403102840 　

  85. Reassessment of non-Hodgkin's lymphoma with a "nodular" growth variant: a clinicopathologic study of follicular, mantle cell and marginal zone lymphomas prospectively diagnosed with multiparameter analyses

    Kadowaki, I, R Ichinohasama, O Sasaki, J Kimura, JI Kameoka, K Meguro, K Endo, K Tobinai, T Sasaki, T Sawai, K Ooya

    LEUKEMIA & LYMPHOMA　31　(3-4)　393-403　1998/10

    ISSN： 1042-8194

  86. A recurrent nonrandom translocation (3;7)(q27;p12) associated with BCL-6 gene rearrangement in B-cell diffuse large cell lymphoma

    R Ichinohasama, Miura, I, T Funato, Sato, I, C Suzuki, Y Saito, JF Decoteau, JB Myers, ME Kadin, T Sawai, K Ooya

    CANCER GENETICS AND CYTOGENETICS　104　(1)　19-27　1998/07

    DOI： 10.1016/S0165-4608(97)00412-3 　

    ISSN： 0165-4608

  87. <講演抄録>4.舌癌の頚部郭清で気付かれた耳下線Warthin腫瘍の1症例(第32回東北大学歯学会講演抄録)(一般演題)

    吉田 光秀, 熊本 裕行, 一迫 玲, 大家 清, 後藤 哲, 佐藤 修一, 川村 仁

    東北大学歯学雑誌 = Tohoku University dental journal　17　(1)　103-103　1998/06/01

    ISSN： 0287-3915

  88. A case of Wartin's tumor of the parotid gland found in a specimen extirpated on radical neck dissection for tongue carcinoma

    Mitsuhide Yoshida, Hiroyuki Kumamoto, Ryo Ichinohasama, Kiyoshi Ooya, Satoshi Goto, Shuichi Sato, Hiroshi Kawamura, Tohoku University School of Dentistry, Department of Oral Pathology Tohoku University School of Dentistry, Department of Oral Pathology Tohoku University School of Dentistry, Department of Oral Pathology Tohoku University School of Dentistry, Department of Oral and Maxillofacial Surgery I Tohoku University School of Dentistry, Department of Oral and Maxillofacial Surgery I Tohoku University School of Dentistry, Department of Oral and Maxillofacial Surgery I Tohoku University School of Dentistry

    17　(1)　66-70　1998/06/01

    ISSN： 0287-3915

  89. II-108 穿孔性腹膜炎, 肝膿瘍破裂で発症した劇症型アメーバ性大腸炎の一例

    佐川 純司, 山口 正人, 片山 正文, 田村 亮, 一迫 玲, 小野寺 健, 熊本 裕行

    日本消化器外科学会雑誌　31　(2)　642-642　1998/02/01

    Publisher: 一般社団法人日本消化器外科学会

    ISSN： 0386-9768

  90. 19D13 : An HTLV-I-positive case showing calcium deposition in systemic organs

    Kumamoto H., Ichinohasama R., Onodera K., Ooya K.

    Oral medicine & pathology　2　(2)　107-107　1997/12

    Publisher: Japanese Society for Oral Pathology

    ISSN： 1342-0984

  91. A case of tongue cancer exhibiting multiple metastatic lesionsand hypercalcemia

    Satoshi Kimizuka, Seishi Echigo, Minako Morita, Hiroyuki Kumamoto, Ryo Ichihasama, Department of Oral and Maxillofacial Surgery II Tohoku University School of Dentistry, Department of Oral and MaxillofacialSurgery II Tohoku University School of Dentistry, Department of Oral and Maxillofacial Surgery II Tohoku University School of Dentistry, Department of Oral Pathology Tohoku University School of Dentistry, Department of Oral Pathology Tohoku University School of Dentistry

    16　(1)　37-42　1997/06/01

    ISSN： 0287-3915

  92. Nodal CD 30^+p80^+ anaplastic large cell lymphoma with positive urine cytology : A case report

    NAGASHIMA Maki, ICHINOHASAMA Ryo, MIURA Hirosyu, KANEKO Chika, KITAMI Michiyo, INOUE Hiroko, KAMEOKA Jun-ichi, SAWAI Takashi

    The Journal of the Japanese Society of Clinical Cytology　36　(2)　205-210　1997/03/22

    Publisher: Japanese Society of Clinical Cytology

    ISSN： 0387-1193

  93. 癌治療と癌生物学の新しい展開 非ホジキンリンパ腫におけるp53癌抑制遺伝子の変異と予後

    長田元伸, 石岡千加史, 村川康子, 一迫玲, 金丸龍之介, 井川俊太郎

    癌と化学療法　24　(4)　471-475　1997/02

    ISSN： 0385-0684

  94. Carbamazepine Induced Erythroderma with Systemic Lymphadenopathy

    OKUYAMA Ryuhei, ICHINOHASAMA Ryo, TAGAMI Hachiro

    J Dermatol　23　(7)　489-494　1996/07/01

    ISSN： 0385-2407

  95. Establishment and Characterization of a Clonal Human Extraskeletal Ewing's Sarcoma Cell Line

    HATORI M

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　70　(6)　S896　1996/06/25

    ISSN： 0021-5325

  96. Extradural Granulocytic Sarcoma of the Thoracic Spine in Acute Myelogenous Leukemia with 8 ; 21 Chromosome Translocation

    AIZAWA TOSHIMI, KOKUBUN SHOICHI, HATORI MASAHITO, KASHIMOTO OSAMU, ICHINOHASAMA RYO

    178　(4)　431-436　1996/04/01

    ISSN： 0040-8727

  97. ANAPLASTIC LARGE-CELL LYMPHOMAS EXPRESSING THE NOVEL CHIMERIC PROTEIN P80(NPM/ALK) - A DISTINCT CLINICOPATHOLOGICAL ENTITY

    M SHIOTA, S NAKAMURA, R ICHINOHASAMA, M ABE, T AKAGI, M TAKESHITA, N MORI, J FUJIMOTO, J MIYAUCHI, A MIKATA, K NANBA, T TAKAMI, H YAMABE, Y TAKANO, T IZUMO, T NAGATANI, N MOHRI, K NASU, H SATOH, H KATANO, J FUJIMOTO, T YAMAMOTO, S MORI

    BLOOD　86　(5)　1954-1960　1995/09

    ISSN： 0006-4971

  98. Establishment and Characterization of a Clonal Human Malignant Schwannoma Cell Line

    HATORI M

    日本整形外科學會雜誌 = The Journal of the Japanese Orthopaedic Association　69　(8)　S1624　1995/08/25

    ISSN： 0021-5325

  99. Disseminated nasal T cell lymphoma with a partial deletion of the LMP1 oncogene in a patient with chronic active Epstein-Barr virus infection.

    Minegishi M, Ohashi Y, Tsuchiya S, Fujie H, Ichinohasama R, Nakagawa H, Konno T

    Leukemia　9　(9)　1595-1598　1995

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Research Projects 6

  1. 濾胞性リンパ腫の新規予後予測モデルの開発

    福原 規子, 一迫 玲

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  2. Clinicopathological study of rare refractory lymphoma based on a long-term cohort study

    FUKUHARA NORIKO

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    For a diagnosis of DLBCL with MYC translocation, it is critical to perform genetic analysis. We therefore devised a notation that we termed proportion of immunoreactivity/expression for immunohistochemistry based on the cellular proportion showing different antigen-antibody reactivity in immunohistochemistry. The most common notation was "+/(weak)+/-" (49/82 cases [59.8%]); cases that were MYC-IHC positive, weakly positive, and negative for tumor cells each accounted for about one-third of the total and no MYC translocation was observed by FISH. FISH is not needed even if more than half of cells are c-MYC positive by this new notation.

  3. Clinicopathological features of malignant lymphoma in Miyagi study.

    Ichinohasama Ryo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2018/03/31

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    We searched all cases of newly diagnosed lymphoid leukemia and/or lymphoma in Miyagi Prefecture over a 5-year period, including those that were discovered as lymphoid leukemia and/or lymphoma sorely after autopsy. We registered the actual number of 2098 cases in the prefecture and calculated an accurate incidence rate (17.8 per 100,000 persons). Additionally, we identified more realistic and detailed frequencies of lymphoid leukemia and/or lymphoma subtypes including the leukemic phase of some lymphomas. As Miyagi Prefecture is an area in which the population dynamics are relatively stable and representative of Japan, the result of our epidemiological study can be used as the first representative index of lymphoid leukemia and/or lymphoma for Japan.

  4. Clinicopathological features of malignant lymphoma in Miyagi study

    ICHINOHASAMA Ryo, FUKUHARA Noriko, ISHIZAWA Kenichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    A total of 3,043 cases of newly diagnosed malignant lymphoma in Miyagi between 2002 and 2012 were enrolled in this epidemiological study. The rate of each subtype was mostly similar to that in our previous report. The most frequent subtype of B-cell lymphoma was diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (38.6%, 19.7% and 7.5%). To identify the biological prognostic factors in DLBCL, we analyzed biological parameters (BCL2, BCL6, c-MYC and BACH2). In cases with high BACH2 expression in GCB (38 cases) and non-GCB groups (38 cases), the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256). In the DLBCL with MYC translocation (n=18), expression of BACH2 may be a prognostic marker (3y OS 75.0% vs 22.9%, P=0.132). BACH2, a B cell-specific transcriptional repressor, may plays a significant role in B cell lymphoma.

  5. Clinicopathological features of malignant lymphoma in Japan : Miyagi Study

    ICHINOHASAMA Ryo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2008 - 2010

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    A total of 1,552 cases of newly diagnosed malignant lymphoma in Miyagi prefecture between 2002 and 2008 were enrolled in this epiemiological study. The rate of follicular lymphoma (24%) was higher than that in previous reports from Asian countries, and similar to that in Western countries. The analysis of each subtype of B-cell lymphoma revealed the incidence for lack of CD20 expression by either flow cytometry or immunohistochemistry (4% or 4%) and the discrepancy of CD20 expression between the results of flow-cytometry and immunohistochemistry (6.3%).

  6. Molecular analysis of DNA mismatch repair gene on human malignant lymphoma occurring in maxillo-facial and oral region

    ICHINOHASAMA Ryo, ECHIGO Seishi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    1999 - 2001

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    Microsatellite instability has been reported in human lymphomas of follicular center cell origin suggesting that deficient DNA mismatch repair may play a role in the development of these tumors. However, a link between loss of MMR gene expression and abnormalities in tumor suppressor genes targeted by deficient MMR gene function has not been established in follicular lymphoma (FL). We evaluated 22 human t(14;18) chromosomal translocation positive FL cases for abnormalities in hMSH2 and hMLH1 expression and insertion/deletion (ID) mutations within the coding region nucleotide repeats of the BAX and TGF-b receptor type two (TbR-II) genes. Loss of hMSH2 or hMLH1 protein expression within the malignant follicles was identified in 6 of 22 (27%) FL cases by immunohistochemistry (IHC). Sequencing of the entire coding regions of hMSH2 and hMLH1 identified mutations in 2 of 2 FL cases that showed loss of hMSH2 protein expression and in 1 of 4 FL cases that showed loss of hMLH1 protein expression. There were no mutations in either hMSH2 or hMLH1 in six control FL cases that showed normal expression of these proteins. All six FL cases showing loss of hMSH2 or hMLH1 protein expression were evaluated for ID mutations within the BAX and TRb-II repeats using high fidelity PCR amplification over the repeat areas followed by blunt end cloning and sequencing. ID mutations within the BAX (G)8 and /or TbR-II (A)10 repeats were identified in five of these FL cases whereas all six control FL cases with normal hMSH2 and hMLH1 protein expression lacked ID mutations. Assessment of BAX protein expression by IHC showed absent or markedly diminished expression in 4 of 6 (67%) FL cases that had evidence of deficient MMR gene function, including both FL cases with BAX ID mutations. In contrast, only 3 of 16 (19%) FL cases that lacked evidence of deficient MMR gene function showed absent or diminished expression of BAX protein. These findings implicate deficient MMR gene function in the pathogenesis of human FL and suggest that IHC screening for hMSH2 and hMLH1 protein expression may represent an efficient method to identify FL cases that arise via this pathway.

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