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Chiharu Ota

Section

Graduate School of Medicine

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/chipaota

J-GLOBAL ID

201801014471015473

e-Rad No.

00733106

ORCID

https://orcid.org/0000-0002-0644-1144

Research History 10

2022/06 - Present

Tohoku University Graduate School of Medicine　Department of environment and developmental Medicine　Professor
2017/09 - Present

Department of Pediatrics, Tohoku University Hospital
2015/10 - 2017/08

Comprehensive Pneumology Center　Postdoctoral fellow
2008/06 - 2009/10

Michigan State University, Department of Physiology
2008/04 - 2008/05

シアトル小児病院麻酔科
2005/04 - 2008/03

宮城県立こども病院麻酔集中治療科
2004/10 - 2005/03

公立気仙沼病院小児科
2004/03 - 2004/09

Department of Pediatrics, Tohoku University Hospital
2003/04 - 2004/03

北九州市立八幡病院小児救急センター
2000/04 - 2003/03

東北厚生年金病院小児科

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Education 4

Ludwig Maximilian University of Munich　Comprehensive Pneumology Center

2015/10 - 2017/09
Tohoku University　Faculty of Medicine　School of Medicine

2010/04 - 2014/03
Michigan State University　Department of Physiology

2008/07 - 2009/10
Tohoku University　School of Medicine

1994/04 - 2000/03

Committee Memberships 6

宮城県小児保健協会　会長

2025/04 - Present
日本小児科学会　小児救急・集中治療委員会

2024/04 - Present
宮城県災害時小児周産期リエゾン

2023/03 - Present
宮城県医師会　環境保健委員会委員

2022/06 - Present
宮城県小児科医会　小児医療体制・小児救急委員会

2022/06 - Present
Japan Pediatric Society　Chiharu Ota

2020/10 - Present

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Research Interests 5

birth cohort study
FACS
alveolar epithelial cells
lung cell isolation
lung injury and repair

Research Areas 1

Life sciences / Fetal medicine/Pediatrics / pediatric pulmonology, pediatric cardiology

Awards 2

JRS Young Scientist Award

2021/11　The 25th Congress of the Asian Pacific Society of Respirology (APSR 2021)
優秀演題賞

2007/11　日本小児麻酔学会

Papers 95

Parenting attitude towards children with autism spectrum disorders: the Japan environment and children's study. International-journal

Keita Kanamori, Tomohisa Suzuki, Chiharu Ota

BMJ paediatrics open　8　(1)　2024/04/04

DOI： 10.1136/bmjpo-2023-002360 　

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OBJECTIVE: The primary objective of this study was to investigate the parenting attitudes towards children with autism spectrum disorders in early childhood in Japan. DESIGN: This study was a cohort study. The participants were enrolled from January 2011 to March 2014. We obtained the prevalence of autism spectrum disorders at 3 years of age, parenting attitudes and other factors from questionnaires. We divided the participants into two groups, an autism spectrum disorders group and a non-autism spectrum disorders group, and compared the parenting attitudes. SETTING: This study used data from a Japanese birth cohort study: the Japan Environment and Children's Study, conducted across 15 regional centres in Japan. PARTICIPANTS: The full dataset of the Japan Environment and Children's Study comprised 104 059 records. We excluded 17 889 records because the answer for the autism spectrum disorders in the questionnaire was blank. As a result, we analysed the remaining 82 411 mother-child pairs. MAIN OUTCOME MEASURES: The primary outcome variable was parenting attitudes at 3.5 years of age, which was assessed using a questionnaire. We asked respondents 16 questions related to parenting attitudes, and they answered based on their behaviours. The independent variable was the prevalence of autism spectrum disorders at 3 years of age. RESULTS: Of the 82 411 participants, the children with autism spectrum disorders at 3 years of age were 372 (0.45%). In most questions about parenting attitudes, the autism spectrum disorders group had unfavourable responses. The difference was particularly noticeable when the parents taught their children social discipline. Unfavourable parenting attitudes were 16.6% in the autism spectrum disorders group and 0.8% in the non-autism spectrum disorders group in the question item with the largest difference between the two groups, a significant difference. CONCLUSIONS: Parents of children with autism spectrum disorders tended to have unfavourable attitudes, suggesting the importance of parental training.
Environments affect blood pressure in toddlers: The Japan Environment and Children's Study. International-journal

Keita Kanamori, Tomohisa Suzuki, Nozomi Tatsuta, Chiharu Ota

Pediatric research　95　(1)　367-376　2023/08/26

DOI： 10.1038/s41390-023-02796-8 　

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BACKGROUND: The primary objective of this study was to examine risk factors for toddler's hypertension. METHODS: Subjects of this study were children and parents participating in a national birth cohort study in Japan, the Japan Environment and Children's Study. We measured the children's blood pressure (BP) at 2 and 4 years old. We obtained children's and parents' backgrounds from the questionnaire. We investigated the factors that affect BP elevation. RESULTS: Within 4988 participants, the mean systolic BP at 2 years old was 91.2 mmHg for boys and 90.0 mmHg for girls. The mean systolic BP at 4 years old was 93.8 mmHg for boys and 93.1 mmHg for girls. Parental smoking was associated with elevated values of BP at 2 and 4 years old. Obesity, gestational hypertension, and parental lower education were associated with elevated values of BP at 4 years old. Hypertensive group had a significantly higher obesity rate. The mother's lower education and parental smoking were involved in hypertensive groups. CONCLUSION: Parental smoking had a significant effect on BP even in early toddlers. We emphasize the importance of avoiding second-hand smoking from early infancy to prevent future lifestyle-related illnesses including hypertension. IMPACT: The mean systolic BP at 2 years old was 91.2 mmHg for boys and 90.0 mmHg for girls. The mean systolic BP at 4 years old was 93.8 mmHg for boys and 93.1 mmHg for girls. Obesity, parental smoking, and lower education were associated with hypertension at 4 years old. Parental smoking was associated with hypertension at 2 and 4 years old. We emphasize the importance of avoiding second-hand smoking from early infancy.
Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease. International-journal

Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawai, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki

Frontiers in cardiovascular medicine　10　1212882-1212882　2023

DOI： 10.3389/fcvm.2023.1212882 　

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AIMS: Limited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH. METHODS: This retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death. RESULTS: The 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45-13.73; P = .009). CONCLUSIONS: The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.
Bilateral lung transplantation in a 9-year-old girl with bronchopulmonary dysplasia with pulmonary hypertension. International-journal

Chiharu Ota, Ryoko Saito, Junya Tominaga, Shinya Iwasawa, Takashi Hirama, Yasushi Matsuda, Katsunori Ono, Takehiko Onoki, Masato Kimura, Yoshinori Kawabata, Yoshinori Okada

Pediatric pulmonology　56　(10)　3417-3421　2021/08/05

DOI： 10.1002/ppul.25597 　

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BACKGROUND: Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease that occurs in premature infants and the prognosis is variable depending on the comorbidities including fibrosis, emphysema, or pulmonary hypertension (PH). We present a case of a 9-year-old girl who developed PH associated with severe BPD (BPD-PH) and underwent bilateral lung transplantation (BLTx). Case description A 9-year-old girl was admitted to our department to undergo BLTx. She was born at 23 weeks and 4 days gestation with a weight of 507 g. She received ventilation for the first 2 months and required further respiratory care due to repetitive, severe respiratory infections. She was diagnosed with BPD-PH at 6 months of age and oral administration of pulmonary vasodilators were initiated. She was registered as a lung transplant candidate at 4 years of age after the life-threatening exacerbation. Chest computed tomography (CT) revealed severe lung conditions with ground-glass opacities and emphysematous low-density areas in the upper and lower lobes. BLTx from a brain-dead male donor was performed. The pathological findings of her resected lung revealed saccular, hypoplastic lung with alveolar repair/regeneration, and medial hypertrophy and muscularization of peripheral arteries. The postoperative course was mostly uneventful. She was free from oxygen administration and showed no signs of PH after 6 months of the surgery. CONCLUSION: This is the first case report of BLTx in a pediatric, irreversible BPD-PH patient with detailed pathohistological findings and clinical examination. Lung transplantation is one of the treatment options for severe BPD-PH.
Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling. International-journal Peer-reviewed

Chiharu Ota, Hoeke A Baarsma, Darcy E Wagner, Anne Hilgendorff, Melanie Königshoff

Molecular and cellular pediatrics　3　(1)　34-34　2016/12

DOI： 10.1186/s40348-016-0062-6 　

ISSN： 2194-7791

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Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
ABCA3 mutations led to pulmonary fibrosis and emphysema with pulmonary hypertension in an 8-year-old girl. International-journal Peer-reviewed

Chiharu Ota, Masato Kimura, Shigeo Kure

Pediatric pulmonology　51　(6)　E21-3-E23　2016/06

DOI： 10.1002/ppul.23379 　

ISSN： 8755-6863

eISSN： 1099-0496
Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. International-journal Peer-reviewed

Chiharu Ota, Mitsuhiro Yamada, Naoya Fujino, Hozumi Motohashi, Yukiko Tando, Yusuke Takei, Takaya Suzuki, Toru Takahashi, Satoshi Kamata, Tomonori Makiguchi, Mutsuo Yamaya, Hiroshi Kubo

Experimental lung research　41　(8)　422-34　2015

DOI： 10.3109/01902148.2015.1060275 　

ISSN： 0190-2148

eISSN： 1521-0499
A cross-sectional study investigating the association between parental daily brushing, extended breastfeeding, or parental smoking habit and early childhood dental caries in 4-year-old children: the Japan Environment and Children's Study. International-journal

Yuichiro Miura, Tomohisa Suzuki, Keita Kanamori, Masahiro Tsuchiya, Chiharu Ota

BMC pediatrics　25　(1)　613-613　2025/08/08

DOI： 10.1186/s12887-025-05997-8 　

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BACKGROUND: Dental caries is estimated to affect almost half of preschool children worldwide and is associated with low academic performance in school age and poor health in adulthood. Thus, the prevention of dental caries is an important issue that must be addressed. The objective of this study was to clarify the factors associated with early childhood dental caries (ECC) in 4-year-old children. METHODS: This study was part of an ongoing nationwide cohort study; the Japan Environment and Children's Study. Approximately 100,000 expectant mothers were recruited from 15 Regional Centers between January 2011 and March 2014. Questionnaires were regularly administered to participating mothers. Data on the presence of ECC at 4 years of age, frequency of parental brushing, continuation of breastfeeding, parental smoking habits, and other factors considered to be related with development of ECC were obtained from the datasets released in October 2019 and April 2021. Then, the data were statistically analyzed. RESULTS: After excluding 25,990 cases due to missing data referring to the prevalence of ECC, 74,310 cases were analyzed. The logistic regression analysis revealed that occasional parental brushing (adjusted odds ratio (aOR) 1.33, 95% confidence interval (95% CI) 1.27-1.39) was associated with significantly increased odds for ECC when compared to routine parental brushing. In addition, extended breastfeeding (aOR 2.07, 95% CI 1.86-2.29), continued smoking of mothers (aOR 1.42, 95% CI 1.30-1.55), and continued smoking of fathers (aOR 1.25, 95% CI 1.20-1.31) were associated with increased odds for ECC. CONCLUSION: Irregular parental brushing, extended breastfeeding, and parental smoking habits were found to be associated with increased odds for ECC in 4-year-old children.
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. International-journal

Darcy Elizabeth Wagner, Hani N Alsafadi, Nilay Mitash, Aurelien Justet, Qianjiang Hu, Ricardo Pineda, Claudia Staab-Weijnitz, Martina Korfei, Nika Gvazava, Kristin Wannemo, Ugochi Onwuka, Molly Mozurak, Adriana Estrada-Bernal, Juan Cala-Garcia, Katrin Mutze, Rita Costa, Deniz Bölükbas, John Stegmayr, Wioletta Skronska-Wasek, Stephan Klee, Chiharu Ota, Hoeke A Baarsma, Jingtao Wang, John Sembrat, Anne Hilgendorff, Jun Ding, Andreas Günther, Rachel Chambers, Ivan Rosas, Stijn de Langhe, Naftali Kaminski, Mareike Lehmann, Oliver Eickelberg, Melanie Königshoff

Nature communications　16　(1)　7099-7099　2025/08/02

DOI： 10.1038/s41467-025-61795-x 　

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Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate production and crosslinking of extracellular matrix via the co-transcriptional activator YAP. YAP leads to increased expression of Lysl oxidase (LOX) and subsequent LOX-mediated crosslinking by fibrotic alveolar type II cells. Pharmacological YAP inhibition via verteporfin reverses fibrotic alveolar type II cell reprogramming and LOX expression in experimental lung fibrosis in vivo and in human fibrotic tissue ex vivo. We thus identify YAP-TEAD/LOX inhibition in alveolar type II cells as a promising potential therapy for IPF patients.
Associations of heart rates and respiratory rates with lifestyle and environmental factors in toddlers: a nationwide cohort study. International-journal

Keita Kanamori, Tomohisa Suzuki, Chiharu Ota

BMC pediatrics　25　(1)　510-510　2025/07/02

DOI： 10.1186/s12887-025-05867-3 　

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BACKGROUND: Heart rate (HR) and respiratory rate (RR) are key vital signs, yet few large studies have reported their normal values in toddlers. We thus assessed HR and RR in two-year-old Japanese children. Given that body size may influence vital signs, we first assessed the correlations of height and weight with HR and RR. We also examined associations of HR and RR with physical activity levels and residential region, as these factors have been linked to vital signs in adults. METHODS: This prospective cohort study included children from the Japan Environment and Children's Study. We measured their HR, RR, height, and weight at two years of age, and assessed their outdoor playtime from one to two years of age using a questionnaire. Participants without HR or RR data were excluded from the analysis. Descriptive statistics for HR and RR at two years of age were summarized. In addition, the correlation coefficient between the participants' height or weight and HR or RR were calculated. We investigated the association between the region or outdoor playtime and HR or RR using a one-way analysis of variance and multiple regression analyses. The covariates included medical history, mother's gestational hypertension, parents' height and weight, parents' smoking status, and parents' educational background. RESULTS: A total of 4,805 participants were included in the HR analysis, and 4,806 in the RR analysis. The mean HR and RR of were 109.2 ± 14.7 beats/min and 29.9 ± 6.1 breaths/min (mean ± standard deviation), respectively. No correlation was found between height or weight and HR or RR. The mean HR of participants who almost never spent time playing outdoors was 111.7 beats/min, whereas that of participants who spent ≥ 3 h/d playing outdoors was 108.2 beats/min (p = 0.038). The mean HR in Eastern Japan was 106.8 /min, whereas that in Western Japan was 112.7 beats/min (p < 0.001). CONCLUSION: We assessed the normal HR and RR in Japanese children aged two years, and these normal ranges did not correlate with height and weight. A longer duration of outdoor playtime was associated with a lower HR.
Association between paternal physique and obesity in children at the age of 3 years: the Japan Environment and Children's Study. International-journal

Yui Inoue, Maki Yokoyama, Shota Inoue, Matome Imai, Hiroshi Onji, Akiko Yano, Yuka Uchikura, Yuko Matsubara, Keiichi Matsubara, Hirotaka Hamada, Hasumi Tomita, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito, Takashi Sugiyama

Journal of developmental origins of health and disease　16　e17　2025/03/21

DOI： 10.1017/S2040174424000473 　

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Obesity during development has been reported to be a determinant factor in the future development of non-communicable diseases (NCDs). Parental obesity is suggested to be a predictor of children's obesity, and it is important to consider parental factors to prevent NCDs in the progeny. Previously, we showed that paternal height had a stronger association with infant birth weight than paternal body mass index (BMI) in the Japanese population. However, only a few studies have examined the association between paternal physique and postnatal obesity. This study aimed to investigate the association between parental physique and obesity in children at the age of 3. This study used fixed data on 33,291 parent-child pairs from the Japan Environment and Children's Study, an ongoing national birth cohort study. The association between paternal physique (BMI and height) and children's obesity at the age of 3 was examined using multivariate logistic regression analysis. The higher the paternal BMI quartiles, the higher the odds ratio for obesity in male and female children at 3 years of age (P < 0.0001). However, paternal height quartiles were not associated with male or female obesity. These results differ from the association between paternal physique and infant birth weight, and it is possible that prenatal epigenetic and environmental factors of paternal origin were responsible for the differences between these two studies. The association between paternal BMI and obesity in children at the age of 3 suggests that paternal factors may be involved in the development of NCDs in future progeny.
Prospective association of daily toothbrushing frequency and the prevalence of childhood functional constipation: the Japan Environment and Children's Study. International-journal

Masahiro Tsuchiya, Shinobu Tsuchiya, Haruki Momma, Ryoichi Nagatomi, Nobuo Yaegashi, Takahiro Arima, Chiharu Ota, Kaoru Igarashi, Yuichiro Miura

Scientific reports　15　(1)　7753-7753　2025/03/05

DOI： 10.1038/s41598-025-88562-8 　

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Functional constipation is the most common gastrointestinal disorder during childhood. Oral stimulation (mastication and toothbrushing) reportedly improves bowel movements, but the association between daily toothbrushing behavior and functional constipation remains unknown. Data (n = 83,660) from fetal records (n = 104,059) in the Japan Environment and Children's Study, an ongoing prospective birth cohort, were analyzed to investigate the impact of daily toothbrushing frequency on functional constipation during childhood, using ROME III diagnostic criteria. After multiple imputations of data acquired from self-reported questionnaires, a multivariable binomial logistic regression analysis was used with adjustments for several maternal and child-related variables. Functional constipation was observed in 10,123 (12.1%) and 8,820 (10.5%) participants at 3 and 4 years postpartum, respectively. Using the appropriate frequency of daily toothbrushing (twice or more) as a reference, the odds of functional constipation increased with decreasing daily toothbrushing frequency after covariate adjustments involving daily feeding frequency. The adjusted odds ratio (OR) for functional constipation in participants without daily toothbrushing behavior (less than once a day) at 4 years postpartum was 1.87 (95% confidence interval [CI] 1.34-2.61). Similarly, the adjusted OR (95% CI) for chronic functional constipation (at both 3 and 4 years postpartum) in participants without daily toothbrushing behavior (less than once a day) at 2 years postpartum was 1.62 (1.14-2.31). Functional constipation during childhood was associated with decreased daily toothbrushing frequency. Although the underlying mechanism of daily toothbrushing behavior in prompting bowel movements remains unclear, it is a major basis of self-health management in children that plays an important role in managing functional constipation.
Impact of maternal smoking and secondhand smoke exposure during singleton pregnancy on placental abruption: analysis of a prospective cohort study (the Japan Environment and Children's Study). International-journal

Hikaru Karumai-Mori, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

BMJ open　15　(3)　e089499　2025/03/04

DOI： 10.1136/bmjopen-2024-089499 　

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OBJECTIVES: This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking and secondhand smoke (SHS) exposure during pregnancy with placental abruption. DESIGN: Prospective cohort study. SETTING: 15 regional centres in Japan. PARTICIPANTS: Pregnant women registered between January 2011 and March 2014 from the Japan Environment and Children's Study. OUTCOME MEASURES: Data were transcribed from medical records and two self-administered questionnaires. The outcome measure was the incidence of placental abruption. Maternal smoking exposure during pregnancy was categorised based on the number of cigarettes smoked (≤10 or ≥11 cigarettes per day). SHS exposure during pregnancy was evaluated by frequency and duration (almost never or never, 1-3 days/week and/or <1 hour/day and 4-7 days/week and ≥1 hour/day). A modified Poisson regression model, adjusted for known placental abruption risk factors, calculated the risk ratio (RR) and PAF for placental abruption with a 95% Cl. RESULTS: Of the 81 974 eligible pregnant women, pregnant women smoking ≥11 cigarettes/day during pregnancy had a significantly higher risk of placental abruption. The adjusted RR (aRR) was 2.21 (95% CI 1.21 to 4.06), and the adjusted PAF (aPAF) was 1.90% (95% CI 0.09 to 3.71%). Pregnant women among never-smokers with SHS exposure of 4-7 days/week and ≥1 hour/day had a significantly higher risk (aRR: 2.34, 95% CI 1.29 to 4.28), and the aPAF was 1.89% (95% CI -0.05 to 3.83). Additionally, pregnant women among those who smoked during pregnancy with similar SHS exposure had a significantly higher risk (aRR: 2.21, 95% CI 1.30 to 3.76), with the aPAF of 2.29% (95% CI 0.11 to 4.48). CONCLUSIONS: Maternal smoking and SHS exposure during pregnancy significantly contribute to the risk of placental abruption in Japan. Therefore, preventive interventions and measures to reduce exposure are required to prevent placental abruption.
Elucidation of Factors Affecting Anterior Occlusion in Primary Dentition Based on the Japan Environment and Children’s Study International-journal

Risa Ishiko, Kotaro Sena, Ichie Koseki, Masumi Sasai, Chiharu Ota, Takeyoshi Koseki

Children　12　(2)　2025/02

DOI： 10.3390/children12020254 　

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Background/Objectives: Malocclusion in primary dentition affects permanent dentition. However, the factors contributing to malocclusion in the oral cavities of children have not been fully elucidated. We hypothesized that environmental factors affect malocclusion in the primary dentition of the Japanese population and aimed to identify factors associated with anterior occlusion in primary dentition. Methods: The study involved 3793 parent-child pairs from the Miyagi Regional Centre as part of a supplementary survey to the Japan Environment and Children's Study, a cohort study. A questionnaire assessing oral development and environmental factors was administered to parent-child pairs who consented to participate. Parents assessed anterior occlusion when their children were 3.5 years old. Results: The maxillary primary central incisors tended to erupt earlier in the open bite group. Significantly more children in this group were breastfed until 1 year and drank ionic beverages at 1.5 years. In addition, thumb sucking or pacifier use was significantly common at 2 years of age. A correlation was observed between the mother's body mass index (BMI) before and after pregnancy and anterior occlusion. Conclusions: In the open bite group, the occlusion status of the anterior teeth at 3.5 years of age showed distinctive results influenced by the eruption period of the primary anterior teeth, oral habits, intake of sweetened beverages, and maternal BMI. These findings suggest that parental observation could be useful for screening children for malocclusion until the eruption of permanent dentition.
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　16　(4)　735-743　2025/01/11

DOI： 10.1111/jdi.14400 　

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AIMS: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). METHODS: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years. RESULTS: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively. CONCLUSIONS: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.
Neonatal Transient Eosinophilic Colitis with a Dilated Digestive Tract and High Luminosity of the Amniotic Fluid During Fetal Period

熊坂衣織, 熊坂衣織, 星雄介, 渡邉達也, 角田文彦, 虻川大樹, 大田千晴, 大田千晴

日本新生児成育医学会雑誌(CD-ROM)　37　(1)　2025

ISSN： 2189-7549
Group childcare has a positive impact on child development from the Japan Environment and Children's Study. International-journal

Keita Kanamori, Tomohisa Suzuki, Chiharu Ota

Scientific reports　14　(1)　29550-29550　2024/11/28

DOI： 10.1038/s41598-024-81343-9 　

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This study aimed to investigate the impact of early group childcare on child development using data from the Japan Environment and Children's Study. This prospective cohort study enrolled participants between January 2011 and March 2014. The Ages and Stages Questionnaires (ASQ)-3 was used to obtain data regarding group childcare and other factors. The participants were divided into two groups: the early childcare group (exposed group) and the non-early childcare group (control group). The ASQ-3 scores in all five domains, i.e., communication, gross motor skills, fine motor skills, problem-solving, and personal-social skills, were compared. A total of 39,894 participants were included in this study. The exposed and control groups comprised 13,674 and 26,220 participants, respectively. The number of participants with the ASQ-3 values below the cut-off value did not differ significantly between the two groups in any of the five domains at six months of age. However, the number of participants with the ASQ-3 values below the cut-off values was significantly lower in the exposed group for all five domains at three years of age. The difference between the two groups, especially in terms of communication and personal-social skills, increased with age.
A Prevalent TMEM260 Deletion Causes Conotruncal Heart Defects, Including Truncus Arteriosus. International-journal

Naoya Saijo, Hisao Yaoita, Jun Takayama, Chiharu Ota, Eiichiro Kawai, Masato Kimura, Akira Ozawa, Gen Tamiya, Shigeo Kure, Atsuo Kikuchi

American journal of medical genetics. Part A　197　(3)　e63906　2024/10/19

DOI： 10.1002/ajmg.a.63906 　

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Conotruncal heart defects are severe congenital malformations of the outflow tract, including truncus arteriosus (TA) and double-outlet right ventricle (DORV). TA is a severe congenital heart disease (CHD) in which the main arterial outflow tract of the heart fails to separate. We recently reported TMEM260 (NM_017799.4), c.1617del (p.Trp539Cysfs*9), as a major cause of TA in the Japanese population (TMEM260 Keio-Tohoku variant) comparable to the prevalence of the 22q11.2 deletion syndrome, which accounts for 12%-35% of TA. However, no other major causes of TA have not been identified. Here, we report a family that included a TA patient and a DORV patient, harboring the compound heterozygous variants of TMEM260, a 7066-bp deletion encompassing exons 6-7 and c.1393C > T, p.(Gln465*). The allele frequency of the 7066-bp deletion was particularly high in the Japanese population (0.17%). Based on the allele frequency of this deletion and c.1617del (0.36%) in the Japanese population, TMEM260 variants might be associated with more than half of the Japanese patients with TA. This study showed that TMEM260 pathogenic variants might be the most common cause of TA in the Japanese population and could explain the wide spectrum of phenotypes associated with TMEM260-related CHD, including DORV, demonstrating the usefulness of genetic testing in Japanese patients with TA.
心不全多職種カンファランスの実践成人先天性心疾患診療における多職種連携

建部俊介, 山本沙織, 佐藤遥, 梶川アユミ, 林秀華, 佐藤大樹, 鈴木秀明, 矢尾板信裕, 後岡広太郎, 高濱博幸, 白戸崇, 矢尾板久雄, 大田千晴, 齋木佳克, 安田聡

日本心臓病学会学術集会抄録　72回　PD1-5　2024/09
Publisher: (一社)日本心臓病学会
【再掲載】将来の小児科医への提言2024(再掲)

村上てるみ, 絹巻暁子, 小林久人, 荒木俊介, 糸永知代, 岩本典子, 大田千晴, 小泉美紀子, 眞田和哉, 高澤啓, 高島光平, 玉井資, 玉崎章子, 鉄原健一, 松島卓哉, 井原健二, 丸尾良浩, 日本小児科学会将来の小児科医を考える委員会

日本小児科学会雑誌　128　(9)　1216-1220　2024/09
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Association between maternal physical activity from pre-pregnancy to child-rearing and their children's physical activity in early childhood among Japanese.

Aya Yamada, Haruki Momma, Nozomi Tatsuta, Kunihiko Nakai, Takahiro Arima, Chiharu Ota, Nobuo Yaegashi, Ryoichi Nagatomi

Journal of epidemiology　35　(2)　81-89　2024/07/20

DOI： 10.2188/jea.JE20240041 　

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INTRODUCTION: This study aimed to determine the association between cumulative maternal physical activity level and their children's physical activity in early childhood. We also compared the influence of each maternal physical activity on children's physical activity in early childhood. METHODS: We analyzed the data from 1,067 Japanese mother-child pairs. Maternal physical activity was assessed using the International Physical Activity Questionnaire. Cumulative physical activity level in mothers was computed based on the categories (low, moderate, and high) of physical activity from 5 time points (pre-pregnancy, during pregnancy, 1.5, 3.5, and 5.5 years postpartum). Children's physical activity level was measured at age 5.5 years using the WHO Health Behaviour School-aged Children questionnaire and defined as engaging in physical activity for at least 60 minutes per day for more than 5 days. Logistic regression analysis was used to determine the association between maternal and children's physical activity levels. RESULTS: The results showed the positive association between cumulative maternal physical activity and children's physical activity level (P for trend < 0.001). Furthermore, maternal physical activity during pregnancy (P for trend = 0.031) and 5.5 years postpartum (P for trend < 0.001) was positively associated with children's physical activity. CONCLUSION: A positive association was observed between the cumulative maternal physical activity level and the physical activity level of their children at 5.5 years of age. Furthermore, maternal physical activity during pregnancy and at 5.5 years postpartum were positively associated with the level of children's physical activity.
【真に役立つ医療DXを複眼で考察する】働き方改革貢献の実際ポータルサイトを活用した大学病院小児科における医局DXの現況と実効化

内田奈生, 山際千鶴, 大田千晴

新医療　51　(7)　40-43　2024/07
Publisher: (株)エムイー振興協会
ISSN： 0910-7991
症例報告の添削過程を録画し,著者と共有する教育的取り組み

柿坂庸介, 多田寛, 森下葵, 浮城一司, 大田千晴

医学教育　55　(3)　264-265　2024/06
Publisher: (一社)日本医学教育学会
ISSN： 0386-9644
Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　15　(6)　751-761　2024/06

DOI： 10.1111/jdi.14159 　

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AIMS: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). METHODS: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000-3499 g as the reference category. RESULTS: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were 1.345 (95% confidence interval [CI]: 0.912-1.984) and 1.338 (95% CI: 1.098-1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were, 1.657 (95% CI: 1.298-2.115) and 1.218 (95% CI: 1.058-1.402), respectively. CONCLUSIONS: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.
A Reduction in the Number of Hospitalized Cases of Acute Meningitis during the COVID-19 Pandemic in Japan.

Tetsuya Akaishi, Kunio Tarasawa, Kiyohide Fushimi, Chiharu Ota, Sumireko Sekiguchi, Tetsuji Aoyagi, Nobuo Yaegashi, Masashi Aoki, Kenji Fujimori

Internal medicine (Tokyo, Japan)　63　(10)　1353-1359　2024/05/15

DOI： 10.2169/internalmedicine.3022-23 　

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Objective The changes in the prevalence of acute meningitis during the coronavirus disease 2019 (COVID-19) pandemic remain unclear. This study aimed to compare the prevalence of acute meningitis before and during the COVID-19 pandemic in Japan. Methods We retrospectively reviewed the Japanese nationwide administrative medical payment system database, Diagnosis Procedure Combination (DPC), from 2016 to 2022. A total of 547 hospitals consistently and seamlessly offered DPC data during this period. The study period was divided into the following three periods: April 2016 to March 2018 (fiscal years 2016-2017), April 2018-March 2020 (2018-2019), and April 2020-March 2022 (2020-2021). Results Among the 28,161,806 patients hospitalized during the study period, 28,399 were hospitalized for acute meningitis: 16,678 for viral/aseptic type, 6,189 for bacterial type, 655 for fungal type, 429 for tuberculous, 2,310 for carcinomatous type, and 2,138 for other or unknown types of meningitis. A significant decrease during the pandemic was confirmed in viral (n=7,032, n=5,775, and n=3,871 in each period; p<0.0001) and bacterial meningitis (n=2,291, n=2,239, and n=1,659; p<0.0001) cases. Meanwhile, no decrease was observed in fungal meningitis (n=212, n=246, and n=197; p=0.056) or carcinomatous meningitis (n=781, n=795, and n=734; p=0.27). The decrease in the number of tuberculous meningitis cases was equivocal (n=166, n=146, and n=117; p=0.014). The decrease during the pandemic was more remarkable in younger populations aged <50 years than in older populations, both for viral and bacterial meningitis. Conclusion The number of hospitalized cases of acute meningitis clearly decreased during the COVID-19 pandemic, especially for viral and bacterial meningitis in younger populations aged <50 years.
将来の小児科医への提言2024

村上てるみ, 絹巻暁子, 小林久人, 荒木俊介, 糸永知代, 岩本典子, 大田千晴, 小泉美紀子, 眞田和哉, 高澤啓, 玉井資, 玉崎章子, 鉄原健一, 松島卓哉, 井原健二, 丸尾良浩, 日本小児科学会将来の小児科医を考える委員会

日本小児科学会雑誌　128　(5)　758-762　2024/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study International-journal

Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Nutrients　16　(4)　2024/02

DOI： 10.3390/nu16040531 　

eISSN： 2072-6643
男性医師の育児休業取得推進を目指して

金森啓太, 金森啓太, 大田千晴, 大田千晴, 大田千晴

日本小児科学会雑誌　128　(10)　2024

ISSN： 0001-6543
Bruxism associated with short sleep duration in children with autism spectrum disorder: The Japan Environment and Children's Study. International-journal

Masahiro Tsuchiya, Shinobu Tsuchiya, Haruki Momma, Ryoichi Nagatomi, Nobuo Yaegashi, Takahiro Arima, Chiharu Ota, Kaoru Igarashi

PloS one　19　(12)　e0313024　2024

DOI： 10.1371/journal.pone.0313024 　

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Bruxism, the involuntary activity of masticatory muscles, is common among individuals with autism spectrum disorders (ASD). Although bruxism is bidirectionally associated with sleep issues, whether an infant's sleep duration contributes to the development of bruxism remains unknown. In this study, a dataset (n = 83,720) obtained from the Japan Environment and Children's Study, a nationwide birth cohort study, was subjected to multiple imputations using logistic regression analysis with adjustments for several maternal and child-related variables. The aim of this study was to assess whether shorter sleep duration in the neonatal period additively affected the high prevalence of parent-reported bruxism (PRB) among children with ASD. The prevalences of ASD and PRB in the participants were 1.2% and 7.2%, respectively, and the odds ratio of the increased risk of PRB prevalence in individuals with ASD (95% confidence interval) was 1.59 (1.31-1.94) after covariate adjustments. Importantly, shorter sleep duration in the neonatal period (at one month of age) was significantly associated with an increased risk of PRB prevalence in individuals with ASD. The increased occurrence of bruxism, known to be highly prevalent among children with ASD, is associated with shorter sleep duration, particularly in the neonatal stage. Based on our results, a better understanding of the development of bruxism in individuals with ASD would provide valuable information for the prevention of oral diseases.
産学連携における最新の動向

中川敦寛, Leor Perl, John Lee, 原田成美, 大田千晴, 志賀卓弥, 角南沙己, 新妻邦泰, 遠藤英徳, 張替秀郎, 冨永悌二

Neurological Surgery　52　(1)　213-225　2024/01
Publisher: (株)医学書院
ISSN： 0301-2603

eISSN： 1882-1251
[Academia-Industry Alliance: Recent Trend].

Atsuhiro Nakagawa, Leor Perl, John Lee, Narumi Harada-Shoji, Chiharu Ota, Takuya Shiga, Sako Sunami, Kuniyasu Niizuma, Hidenori Endo, Hideo Harigae, Teiji Tominaga

No shinkei geka. Neurological surgery　52　(1)　213-225　2024/01

DOI： 10.11477/mf.1436204899 　

ISSN： 0301-2603

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Industry-academia Collaboration is an academic activity within academia(educational institutions such as universities, research institutes, etc.)formed to research and develop new technologies, create new businesses and knowledge, and recruit outsourcing human resources. There is a collaboration between an industry(a private company, a group that engages in broad commercial activities and links research and development directly to economic activity)and academia. Amidst the dramatic changes in the environment surrounding the goals of research and development of new technologies and the creation of new businesses, there are changes in what academia can do complementarily. We will outline the changes and current situation, including the efforts of the Tohoku University Hospital.
Timing of Primary Tooth Eruption in Infants Observed by Their Parents. International-journal

Mina Dodo, Chiharu Ota, Motohiro Ishikawa, Ichie Koseki, Junichi Sugawara, Nozomi Tatsuta, Takahiro Arima, Nobuo Yaegashi, Takeyoshi Koseki

Children (Basel, Switzerland)　10　(11)　2023/10/25

DOI： 10.3390/children10111730 　

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BACKGROUND: The timing of primary teeth eruption is a visible indicator of infant physical growth other than body weight or height. It also reflects neurological integrity and development as well as nutrition, socioeconomic state, or underlying diseases. Therefore, the timing of primary teeth eruption is one of the major concerns for parents in health checkups for infants and children. However, the detailed developmental timing of teeth eruption differs depending on the survey methodology, country, or generation. We hypothesized that the timing of primary teeth eruption differs between the medical checkup by dentists and the daily records by parents. METHODS: We conducted a questionnaire survey on the date of eruption of primary teeth as an adjunct study among Miyagi Regional Center participants in the Japan Environment and Children's Study (JECS), a large-scale birth cohort study. A total of 1695 responses (3793 participants) were analyzed. RESULTS: The median ages of eruption were 7.1 months (male) and 7.6 months (female) for mandibular primary central incisors, 8.7 months (male) and 9.2 months (female) for maxillary primary central incisors, 10.0 months (male) and 10.3 months (female) for maxillary primary lateral incisors, and 10.4 months (male) and 10.8 months (female) for mandibular primary lateral incisors, which were earlier than the reported timings based on dental check-ups. Comparing the eruption time of preterm and term infants, the eruption time was earlier in preterm infants in the corrected ages. CONCLUSIONS: The eruption timing observed and described by the parents is earlier than that examined by dentists at regular check-ups. In addition to examining the primary teeth eruption of full-term birth children, we also examined that of preterm birth children because of the increasing number of premature births. To the best of our knowledge, this is the first report from a large cohort study to clarify the eruption time of primary teeth monitored by parents.
Innovation in Neurosurgery Domain: Leveraging Co-creation with Industry

中川敦寛, 中川敦寛, 中川敦寛, 中川敦寛, 志賀卓弥, 志賀卓弥, 大田千晴, 大田千晴, 佐藤匠隼, 三浦友裕, 冨永悌二

脳神経外科ジャーナル　32　(10)　647-653　2023/10
Publisher:
ISSN： 0917-950X
Exploring the efficacy of an educational approach of case-writing for remote learners: insights from a novice writer. International-journal

Kenko Aoki, Chiharu Ota, Yosuke Kakisaka

Rural and remote health　23　(4)　8527-8527　2023/10

DOI： 10.22605/RRH8527 　

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Combination of Lectures for Case-report Writing and Advances in Internet Technology May Be a Possible Solution for "Encouraging Students and Trainees to Write".

Yosuke Kakisaka, Chiharu Ota, Jun-Ichi Kameoka

JMA journal　6　(3)　360-361　2023/07/14

DOI： 10.31662/jmaj.2023-0045 　
病初期に急性心筋炎と診断された不全型川崎病の15歳女性

沖村聖人, 岩澤伸哉, 星菜美子, 尾形博子, 藤島史喜, 大田千晴

東北医学雑誌　135　(1)　39-42　2023/06
Publisher: 東北医学会
ISSN： 0040-8700
Incidental Hyperferritinemia in Very Young Infants with Mild Symptoms of COVID-19 Disease. International-journal

Yuka Shishido, Haruhiko Nakamura, Tomohiro Nakagawa, Shinsuke Kanou, Takeshi Ito, Shota Kuwana, Chiharu Ota

Children (Basel, Switzerland)　10　(5)　2023/05/12

DOI： 10.3390/children10050874 　

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BACKGROUND: The number of children infected with novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has increased during the outbreak of the Omicron strain. Hyperferritinemia has been reported in severe cases of COVID-19, and in children or neonates with multisystem inflammatory syndrome (MIS). Hyperferritinemia is considered to be one of the signs of MIS, but thus far, there have been few summarized reports on it. We retrospectively analyzed four infants less than 3 months of age with SARS-CoV-2 infections treated in our institution during the outbreak of the Omicron strain. RESULTS: most patients were in good condition, but hyperferritinemia was observed in all of four cases. CONCLUSIONS: Hyperferritinemia can be observed in infantile COVID-19 patients even with mild symptoms. It is necessary to carefully monitor their clinical course and monitor the patients.
Combined Full Median Sternotomy with Left Thoracotomy Approach for Recoarctation of the Aorta Associated with Aortic Regurgitation

松尾諭志, 板垣皓大, 大谷将之, 鈴木佑輔, 片平晋太郎, 大軒健彦, 大田千晴, 岩澤伸哉, 齋木佳克

日本小児循環器学会雑誌　39　(1)　31-36　2023/02
Publisher:
ISSN： 0911-1794

eISSN： 2187-2988
Factors associated with postpartum smoking relapse at early postpartum period of Japanese women in the Japan Environmental and Children's Study.

Akane Anai, Kaname Asato, Nozomi Tatsuta, Kasumi Sakurai, Chiharu Ota, Shinichi Kuriyama, Junichi Sugawara, Takahiro Arima, Nobuo Yaegashi, Kunihiko Nakai

Environmental health and preventive medicine　28　56-56　2023

DOI： 10.1265/ehpm.23-00059 　

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BACKGROUND: Postpartum smoking relapse is a serious public health concern. Previous studies have identified several risk factors for postpartum smoking relapse; however, very little is known about the predictors of early postpartum smoking relapse. This study aimed to determine postpartum smoking relapse status and its associated risk factors at 1 month postpartum among Japanese women. METHODS: Data were obtained from 93,851 mothers with live births in an ongoing birth cohort study, the Japan Environment and Children's Study. Data on smoking status and confounding variables were collected using self-administered questionnaires and medical record transcripts. Self-administered questionnaires were administered during the first trimester, second/third trimester, and 1 month after delivery. A multiple logistic regression analysis was performed. RESULTS: Among the 14,326 mothers who smoked during pregnancy, 10,917 (76.2%) quit smoking during pregnancy. Subsequently, 617 (5.7%) of the mothers who had quit relapsed smoking at 1 month postpartum. Maternal age (≤24, ≥35), maternal education (≤12 years), parity (≥Second), feeding method (Formula milk), partner smoking status during pregnancy (Smoker), number of cigarettes per day before the cessation of smoking (≥11), maternal alcohol consumption at 1-month postpartum (Drinker), postpartum depression (EPDS score ≥9), and spending time at the parents' home after delivery (≥14 days) were associated with smoking relapse. CONCLUSIONS: A certain number of mothers relapsed even 1 month postpartum. Besides mother's alcohol and smoking habit before pregnancy, breastfeeding and partner smoking are important factors in early postpartum smoking relapse in Japan.
Timing of Maternal Smoking Cessation and Newborn Weight, Height, and Head Circumference. International-journal

Nozomi Tatsuta, Kaname Asato, Akane Anai, Tomohisa Suzuki, Kasumi Sakurai, Chiharu Ota, Takahiro Arima, Junichi Sugawara, Nobuo Yaegashi, Kunihiko Nakai

Obstetrics and gynecology　141　(1)　119-125　2023/01/01

DOI： 10.1097/AOG.0000000000004991 　

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OBJECTIVE: To examine the relationship between timing of smoking cessation during pregnancy and anthropometric indices of newborns. METHODS: Mothers and neonates enrolled in the JECS (Japan Environment and Children's Study), a nationwide birth cohort study, were examined. Patients with full-term neonates were included in the analysis, and 73,025 mother-neonate pairs with complete data were identified. The mothers were classified into six groups according to smoking status during pregnancy (nonsmokers [Q1, n=44,198]; ex-smokers who quit before pregnancy [Q2, n=16,461]; ex-smokers who quit in the first trimester [Q3, n=8,948]; ex-smokers who quit in the second trimester [Q4, n=498]; ex-smokers who quit in the third trimester [Q5, n=651]; and smokers who smoked throughout pregnancy [Q6, n=2,269)]). Data on smoking were based on questionnaires administered in the first, second, or third trimester and 1 month after delivery. The primary outcomes were birth weight, height, and head circumference. RESULTS: Compared with nonsmokers (Q1), no adverse outcomes were observed for ex-smokers who quit before pregnancy (Q2). The mean adjusted weights of male and female neonates were 135 g and 125 g lower, respectively, in Q6 participants than in Q1 participants. Comparing Q1 and Q6 participants, height was 0.6 cm and 0.7 cm smaller for male and female neonates, respectively. Head circumference in neonates of Q6 participants was 0.3 cm and 0.3 cm smaller for male and female neonates, respectively, than that in Q1 participants. Across all three measures, smoking cessation in the first and second trimester reduced the differential in outcomes between nonsmokers and individuals who smoked throughout pregnancy. CONCLUSION: Smoking during pregnancy is associated with reduced newborn birth weight, height, and head circumference. Earlier smoking cessation during pregnancy reduces the adverse effects of smoking on fetal growth.
輪状後部静脈叢隆起により嚥下困難をきたした1歳女児例

佐原寛太郎, 大田千晴, 大軒健彦, 岩澤伸哉, 加藤健吾, 安達美佳

東北医学雑誌　134　(2)　75-77　2022/12
Publisher: 東北医学会
ISSN： 0040-8700
急激な経過をたどったhemorrhagic shock and encephalopathy症候群の女児例

渋谷守栄, 及川善嗣, 大田千晴, 渡邊真平, 宇根岡紗希, 相原悠, 堅田有宇, 植松有里佳, 植松貢, 呉繁夫

日本SIDS・乳幼児突然死予防学会雑誌　22　(1)　51-55　2022/12
Publisher: 日本SIDS・乳幼児突然死予防学会
ISSN： 1346-1680
One-year-and-a-month-old girl case with a rich venous plexus in the postcricoid region who showed dysphagia and poor weight gain

佐原寛太郎, 大田千晴, 大軒健彦, 岩澤伸哉, 加藤健吾, 安達美佳

東北医学雑誌(Web)　134　(2)　75-77　2022/12
Publisher:
ISSN： 0040-8700
急激な経過をたどったhemorrhagic shock and encephalopathy症候群の女児例

渋谷守栄, 及川善嗣, 大田千晴, 渡邊真平, 宇根岡紗希, 相原悠, 堅田有宇, 植松有里佳, 植松貢, 呉繁夫

日本SIDS・乳幼児突然死予防学会雑誌　22　(1)　51-55　2022/12
Publisher: 日本SIDS・乳幼児突然死予防学会
ISSN： 1346-1680
Two Distinct Cases of Adult-onset Kawasaki Disease.

Takehiko Onoki, Takaya Metoki, Shinya Iwasawa, Kengo Kawano, Masato Kimura, Shigeo Kure, Chiharu Ota

Internal medicine (Tokyo, Japan)　61　(23)　3525-3529　2022/12/01

DOI： 10.2169/internalmedicine.9044-21 　

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Kawasaki disease (KD) is a systemic vasculitis syndrome that mostly affects children under 4 years old. Among the reported KD cases, only 1% were over 10 years old. We herein report 2 cases of adult-onset KD (AKD) in 19- and 17-year-old boys diagnosed with a persistent fever and cervical lymphadenitis. Both patients showed cardiac complications, such as coronary artery dilation and myocarditis. Repeated intravenous immunoglobulin therapy was effective in the 19-year-old, while plasma exchange therapy was needed for the 17-year-old, with no sequelae noted at discharge. KD should be considered as a differential diagnosis for persistent fever in adults.
小児科専門医の職責・貢献・勤務実態に関する調査研究報告(第1報) ウェブアンケート集計結果

鈴木康之, 宮入烈, 足立壯一, 清水俊明, 高村昭輝, 土井庄三郎, 西屋克己, 松原知代, 三浦健一郎, 吉川哲史, 大田千晴, 嶋岡鋼, 森尾友宏, 森岡一朗, 和田和子, 高橋尚人, 日本小児科学会専門医制度運営委員会

日本小児科学会雑誌　126　(11)　1557-1569　2022/11
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
小児科専門医の職責・貢献・勤務実態に関する調査研究報告(第2報) 小児科専門医の全国動態

鈴木康之, 宮入烈, 足立壯一, 清水俊明, 高村昭輝, 土井庄三郎, 西屋克己, 松原知代, 三浦健一郎, 吉川哲史, 大田千晴, 嶋岡鋼, 森尾友宏, 森岡一朗, 和田和子, 高橋尚人, 日本小児科学会専門医制度運営委員会

日本小児科学会雑誌　126　(11)　1570-1580　2022/11
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Male infant with Noonan syndrome with RAF-1 gene mutation who survived hypertrophic cardiomyopathy-induced fatal heart failure and uncontrollable arrhythmias. International-journal

Mao Hagino, Chiharu Ota, Takehiko Onoki, Shinya Iwasawa

BMJ case reports　15　(9)　2022/09/28

DOI： 10.1136/bcr-2022-250342 　

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Noonan syndrome (NS) is a congenital disease with characteristic facial features as well as heart disease, short stature and thoracic abnormalities. More than eighty per cent of patients with NS show several cardiac disorders including pulmonary valvular stenosis, hypertrophic cardiomyopathy (HCM) and/or atrial septal defects. HCM is a serious cardiac comorbidity in patients with NS, especially in those who are diagnosed within 6 months of age with congestive heart failure. Arrhythmia with or without HCM in NS is a rare comorbidity with a complicated clinical course and poor prognosis.In this manuscript, we present the case of a male infant with NS with RAF1 gene mutation, who showed various types of arrhythmias. He developed life-threatening heart failure and uncontrollable arrhythmias. We attempted several antiarrhythmic agents and finally controlled the arrhythmias to establish a normal sinus rhythm with a combination of amiodarone and flecainide.
Clinical differences between small and medium to giant coronary artery aneurysms of Kawasaki disease Peer-reviewed

Daijiro Sato, Chiharu Ota, Yuka Rokugo, Takehiko Onoki, Masato Kimura, Shinya Iwasawa

Journal of Japanese Society of Emergency Pediatrics　20　(203)　423-431　2021/10
Thoracic Empyema Secondary to Congenital Chylothorax in a 14-Month-Old Boy with Noonan Syndrome. International-journal

Takeru Oikawa, Chiharu Ota, Shinya Iwasawa, Takehiko Onoki, Hideyuki Ikeda, Takushi Hanita

Case reports in pediatrics　2021　6620353-6620353　2021

DOI： 10.1155/2021/6620353 　

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Thoracic empyema usually occurs as a complication of bacterial pneumonia, but in rare cases, it is caused by hematogenous dissemination secondary to nonpulmonary diseases. Congenital chylothorax or chylothorax in children is associated with maldevelopment of the lymphatic system, nonimmune hydrops fetalis, several syndromes including Down syndrome, Noonan syndrome, or Turner syndrome, a complication of thoracic surgery, right heart failure with high central venous pressure, or tumors. There are very few reports of empyema associated with preexisting chylothorax. In the present study, we describe a rare case of thoracic empyema associated with congenital chylothorax and supravalvular pulmonary stenosis associated with clinically diagnosed Noonan syndrome. It is necessary to closely monitor patients with chylothorax because they are at risk of developing severe lung infections, such as pleural empyema or lung abscesses.
Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue. International-journal

Martina M De Santis, Hani N Alsafadi, Sinem Tas, Deniz A Bölükbas, Sujeethkumar Prithiviraj, Iran A N Da Silva, Margareta Mittendorfer, Chiharu Ota, John Stegmayr, Fatima Daoud, Melanie Königshoff, Karl Swärd, Jeffery A Wood, Manlio Tassieri, Paul E Bourgine, Sandra Lindstedt, Sofie Mohlin, Darcy E Wagner

Advanced materials (Deerfield Beach, Fla.)　33　(3)　e2005476　2021/01

DOI： 10.1002/adma.202005476 　

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Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here, a tissue-specific hybrid bioink is described, composed of a natural polymer, alginate, reinforced with extracellular matrix derived from decellularized tissue (rECM). rECM has rheological and gelation properties beneficial for 3D bioprinting while retaining biologically inductive properties supporting tissue maturation ex vivo and in vivo. These bioinks are shear thinning, resist cell sedimentation, improve viability of multiple cell types, and enhance mechanical stability in hydrogels derived from them. 3D printed constructs generated from rECM bioinks suppress the foreign body response, are pro-angiogenic and support recipient-derived de novo blood vessel formation across the entire graft thickness in a murine model of transplant immunosuppression. Their proof-of-principle for generating human tissue is demonstrated by 3D bioprinting human airways composed of regionally specified primary human airway epithelial progenitor and smooth muscle cells. Airway lumens remained patent with viable cells for one month in vitro with evidence of differentiation into mature epithelial cell types found in native human airways. rECM bioinks are a promising new approach for generating functional human tissue using 3D bioprinting.
Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. International-journal

Yan Hu, John-Poul Ng-Blichfeldt, Chiharu Ota, Chiara Ciminieri, Wenhua Ren, Pieter S Hiemstra, Jan Stolk, Reinoud Gosens, Melanie Königshoff

Stem cells (Dayton, Ohio)　38　(11)　1467-1478　2020/11

DOI： 10.1002/stem.3241 　

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Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development and in various adult tissues. Ectopic activation of Wnt/β-catenin signaling promotes tissue repair in emphysema, a devastating lung disease with progressive loss of parenchymal lung tissue. The identity of Wnt/β-catenin responsive progenitor cells and the potential impact of Wnt/β-catenin signaling on adult distal lung epithelial progenitor cell function in emphysema are poorly understood. Here, we used TCF/Lef:H2B/GFP reporter mice to investigate the role of Wnt/β-catenin signaling in lung organoid formation. We identified an organoid-forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β-catenin activity, which was enriched in club and alveolar epithelial type (AT)II cells. Endogenous Wnt/β-catenin activity was required for the initiation of multiple subtypes of distal lung organoids derived from the Wntlow epithelial progenitors. Further ectopic Wnt/β-catenin activation specifically led to an increase in alveolar organoid number; however, the subsequent proliferation of alveolar epithelial cells in the organoids did not require constitutive Wnt/β-catenin signaling. Distal lung epithelial progenitor cells derived from the mouse model of elastase-induced emphysema exhibited reduced organoid forming capacity. This was rescued by Wnt/β-catenin signal activation, which largely increased the number of alveolar organoids. Together, our study reveals a novel mechanism of lung epithelial progenitor cell activation in homeostasis and emphysema.
Informative Aspects of Molten KOH Etch Pits Formed at Basal Plane Dislocations on the Surface of 4H‐SiC

Johji Nishio, Chiharu Ota, Aoi Okada, Ryosuke Iijima

physica status solidi (a)　2020/08

DOI： 10.1002/pssa.202000332 　
Improving the viability of tissue-resident stem cells using an organ-preservation solution. International-journal Peer-reviewed

Takaya Suzuki, Chiharu Ota, Naoya Fujino, Yukiko Tando, Satoshi Suzuki, Mitsuhiro Yamada, Takashi Kondo, Yoshinori Okada, Hiroshi Kubo

FEBS open bio　9　(12)　2093-2104　2019/12

DOI： 10.1002/2211-5463.12748 　

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Human clinical specimens are a valuable source of tissue-resident stem cells, but such cells need to be collected immediately after tissue collection. To extend the timescale for collection from fresh human samples, we developed a new extracellular fluid (ECF)-type preservation solution based on a high-sodium and low-potassium solution containing low-molecular-weight dextran and glucose, which is used for preservation of organs for transplantation. In this study, we compared the preservation of tissue-resident stem cells using our ECF solution with that using three other solutions: PBS, Dulbecco's modified Eagle's medium and Euro-Collins solution. These solutions represent a common buffer, a common culture medium and a benchmark organ-preservation solution, respectively. Lung tissues were removed from mice and preserved for 72 h under low-temperature conditions. Of the solutions tested, only preservation in the ECF-type solution could maintain the proliferation and differentiation capacity of mouse lung tissue-resident stem cells. In addition, the ECF solution could preserve the viability and proliferation of human alveolar epithelial progenitor cells when stored for more than 7 days at 4 °C. The mean viability of human alveolar type II cells at 2, 5, 8 and 14 days of low-temperature preservation was 90.9%, 84.8%, 85.7% and 66.3%, respectively, with no significant differences up to 8 days. Overall, our findings show that use of our ECF-type preservation solution may maintain the viability and function of tissue-resident stem cells. Use of this preservation solution may facilitate the investigation of currently unobtainable human tissue specimens for human stem cell biology.
Preoperative administration of propranolol reduced the surgical risks of PHACES syndrome in a 14-month-old girl. International-journal Peer-reviewed

Yuka Rokugo, Chiharu Ota, Masato Kimura, Yoji Sasahara

BMJ case reports　12　(4)　2019/04/29

DOI： 10.1136/bcr-2018-228117 　

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PHACES syndrome is an uncommon neurocutaneous disorder first identified in 1996. Patients with PHACES syndrome often require surgical treatment for their anomalies, including intracranial vasculopathy, coarctation/interruption of the aorta, intracardiac defects, glaucoma/cataract and sternal defects. Risk factors associated with the symptoms of intraoperative/perioperative management include ischaemic stroke due to the cerebral vasculopathy, airway obstruction due to the subglottic/tracheal haemangiomas and massive bleeding due to the large haemangiomas. Recently, propranolol is considered as first-line therapy for patients with infantile haemangiomas (IHs). However, until now, there have been no reported cases of PHACES syndrome treated by propranolol to reduce the surgical risks associated with IH. In this report, we describe a case of a 14-month-old Japanese girl with PHACES syndrome treated by propranolol for IH before surgical closure of the ventricular septum defect. Oral administration of propranolol was effective in decreasing the size of IH, leading to the uneventful perioperative course.
Preventive effects of pneumococcal and influenza vaccines on community-acquired pneumonia in older individuals in Japan: a case-control study. International-journal

Kanzo Suzuki, Kyoko Kondo, Masakazu Washio, Kei Nakashima, Sakae Kan, Seiichiro Imai, Kunihiko Yoshimura, Chiharu Ota, Satoko Ohfuji, Wakaba Fukushima, Yoshio Hirota

Human vaccines & immunotherapeutics　15　(9)　2171-2177　2019

DOI： 10.1080/21645515.2019.1584023 　

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At present, there are few reports that have clarified the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) against all-cause pneumonia or pneumococcal pneumonia in community-acquired pneumonia (CAP) in older individuals in Japan. We conducted a hospital-based matched case-control study to investigate separately the preventive effects of PPSV23 and trivalent influenza vaccine (TIV) on all-cause CAP and pneumococcal CAP in older individuals in Japan. Cases were individuals aged 65 years or older who were newly diagnosed with CAP from October 2010 to September 2014. Two control patients with a different disease (one respiratory medicine and one non-respiratory medicine) matched for sex, age, date of outpatient visit, and medical institution were selected for each case. Odds ratios (ORs) and 95% confidence intervals (CIs) of PPSV23 and TIV for the occurrence of all-cause CAP and pneumococcal CAP were calculated using conditional and unconditional logistic regression models. The analysis included 161 cases and 308 controls from the 4-year period. The adjusted OR for the occurrence of all-cause CAP was 0.76 (95%CI = 0.44-1.32) with PPSV23 vaccination and 0.79 (95%CI = 0.50-1.25) with TIV vaccination compared with unvaccinated individuals. When the outcome index was restricted to pneumococcal CAP, the adjusted OR significantly decreased to 0.23 (95%CI = 0.08-0.66) with PPSV23 vaccination, but not with TIV vaccination (adjusted OR = 0.65, 95%CI = 0.31-1.36). PPSV23 vaccination is likely effective in reducing incidence of pneumococcal CAP in older individuals, although its preventive effect for all-cause CAP has not been achieved.
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis. International-journal Peer-reviewed

Mareike Lehmann, Lara Buhl, Hani N Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E Wagner, Melanie Königshoff

Respiratory research　19　(1)　175-175　2018/09/15

DOI： 10.1186/s12931-018-0876-y 　

ISSN： 1465-9921

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BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to fibroblast activation, extracellular matrix remodeling, and subsequently loss of lung architecture and function. To date, Pirfenidone and Nintedanib are the only approved drugs known to decelerate disease progression, however, if and how these drugs affect lung epithelial cell function, remains largely unexplored. METHODS: We treated murine and human 3D ex vivo lung tissue cultures (3D-LTCs; generated from precision cut lung slices (PCLS)) as well as primary murine alveolar epithelial type II (pmATII) cells with Pirfenidone or Nintedanib. Murine 3D-LTCs or pmATII cells were derived from the bleomycin model of fibrosis. Early fibrotic changes were induced in human 3D-LTCs by a mixture of profibrotic factors. Epithelial and mesenchymal cell function was determined by qPCR, Western blotting, Immunofluorescent staining, and ELISA. RESULTS: Low μM concentrations of Nintedanib (1 μM) and mM concentrations of Pirfenidone (2.5 mM) reduced fibrotic gene expression including Collagen 1a1 and Fibronectin in murine and human 3D-LTCs as well as pmATII cells. Notably, Nintedanib stabilized expression of distal lung epithelial cell markers, especially Surfactant Protein C in pmATII cells as well as in murine and human 3D-LTCs. CONCLUSIONS: Pirfenidone and Nintedanib exhibit distinct effects on murine and human epithelial cells, which might contribute to their anti-fibrotic action. Human 3D-LTCs represent a valuable tool to assess anti-fibrotic mechanisms of potential drugs for the treatment of IPF patients.
Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis. International-journal Peer-reviewed

Chiharu Ota, John-Poul Ng-Blichfeldt, Martina Korfei, Hani N Alsafadi, Mareike Lehmann, Wioletta Skronska-Wasek, Martina M De Santis, Andreas Guenther, Darcy E Wagner, Melanie Königshoff

Scientific reports　8　(1)　12983-12983　2018/08/28

DOI： 10.1038/s41598-018-31214-x 　

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Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). Homeobox only protein x (HOPX) contributes to the formation of distal lung during development. In adult lung, alveolar epithelial type (AT) I cells express HOPX and lineage-labeled Hopx+ cells give rise to both ATI and ATII cells after pneumonectomy. However, the cell function of HOPX-expressing cells in adult fibrotic lung diseases has not been investigated. In this study, we have established a flow cytometry-based method to evaluate HOPX-expressing cells in the lung. HOPX expression in cultured ATII cells increased over culture time, which was accompanied by a decrease of proSP-C, an ATII marker. Moreover, HOPX expression was increased in AECs from bleomycin-instilled mouse lungs in vivo. Small interfering RNA-based knockdown of Hopx resulted in suppressing ATII-ATI trans-differentiation and activating cellular proliferation in vitro. In IPF lungs, HOPX expression was decreased in whole lungs and significantly correlated to a decline in lung function and progression of IPF. In conclusion, HOPX is upregulated during early alveolar injury and repair process in the lung. Decreased HOPX expression might contribute to failed regenerative processes in end-stage IPF lungs.
Asymptomatic left atrial appendage aneurysm (LAAA) with pericardial defect in a 1-year-old girl. International-journal Peer-reviewed

Chiharu Ota, Masato Kimura, Masahiro Kitami, Shigeo Kure

BMJ case reports　2018　2018/06/04
Publisher: BMJ Publishing Group
DOI： 10.1136/bcr-2018-224573 　

ISSN： 1757-790X
Expression of cytochrome P450 mRNAs in Type II alveolar cells from subjects with chronic obstructive pulmonary disease. International-journal Peer-reviewed

Satoshi Kamata, Naoya Fujino, Mitsuhiro Yamada, Ken Grime, Satoshi Suzuki, Chiharu Ota, Yukiko Tando, Yoshinori Okada, Akira Sakurada, Masafumi Noda, Yasushi Matsuda, Hisatoshi Sugiura, Masakazu Ichinose

Pharmacology research & perspectives　6　(3)　e00405　2018/06

DOI： 10.1002/prp2.405 　

eISSN： 2052-1707
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. International-journal Peer-reviewed

Mareike Lehmann, Martina Korfei, Kathrin Mutze, Stephan Klee, Wioletta Skronska-Wasek, Hani N Alsafadi, Chiharu Ota, Rita Costa, Herbert B Schiller, Michael Lindner, Darcy E Wagner, Andreas Günther, Melanie Königshoff

The European respiratory journal　50　(2)　2017/08

DOI： 10.1183/13993003.02367-2016 　

ISSN： 0903-1936

eISSN： 1399-3003
In response to letter to Editor by Nosaka et al. on our paper: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neurol Sci 2015;349:190-195. International-journal Peer-reviewed

Kazuhiro Haginoya, Guilian Sun, Chiharu Ota, Setsuko Kitaoka, Masaru Takayanagi, Taro Kitamura, Mitsugu Uematsu, Naomi Hino-Fukuyo, Mitsutoshi Munakata, Shigeo Kure

Journal of the neurological sciences　372　50-50　2017/01/15

DOI： 10.1016/j.jns.2016.11.041 　

ISSN： 0022-510X

eISSN： 1878-5883
Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. International-journal Peer-reviewed

Tomonori Makiguchi, Mitsuhiro Yamada, Yusuke Yoshioka, Hisatoshi Sugiura, Akira Koarai, Shigeki Chiba, Naoya Fujino, Yutaka Tojo, Chiharu Ota, Hiroshi Kubo, Seiichi Kobayashi, Masaru Yanai, Sanae Shimura, Takahiro Ochiya, Masakazu Ichinose

Respiratory research　17　(1)　110-110　2016/09/05

DOI： 10.1186/s12931-016-0427-3 　

ISSN： 1465-9921

eISSN： 1465-993X
Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis. International-journal Peer-reviewed

Katsutoshi Ando, Naoya Fujino, Keiko Mitani, Chiharu Ota, Yoshinori Okada, Takashi Kondo, Teruaki Mizobuchi, Masatoshi Kurihara, Kenji Suzuki, Yoshito Hoshika, Hiroki Ebana, Etsuko Kobayashi, Kazuhisa Takahashi, Hiroshi Kubo, Kuniaki Seyama

American journal of physiology. Lung cellular and molecular physiology　310　(10)　L899-908-L908　2016/05/15

DOI： 10.1152/ajplung.00365.2015 　

ISSN： 1040-0605

eISSN： 1522-1504
進行性の心伝導障害に対して予防的にペースメーカー植込みを施行したカーンズ・セイヤー症候群の13歳例

木村正人, 大田千晴, 川合英一郎, 矢尾板久雄, 山村菜絵子, 呉繁夫, 小林朋子, 近藤正輝

日本小児科学会雑誌　120　(5)　916-917　2016/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
FACSによるLAM細胞分離法の確立

安藤克利, 藤野直也, 大田千晴, 岡田克典, 栗原正利, 江花弘基, 高橋和久, 久保裕司, 瀬山邦明

日本呼吸器学会誌　5　(増刊)　275-275　2016/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
特発性肺線維症の予後予測因子としての血清エクソソームmicroRNA

牧口友紀, 山田充啓, 吉岡祐亮, 杉浦久敏, 小荒井晃, 大田千晴, 久保裕司, 小林誠一, 矢内勝, 志村早苗, 一ノ瀬正和

日本呼吸器学会誌　5　(増刊)　334-334　2016/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
Receptor for advanced glycation end products expressed on alveolar epithelial cells is the main target for hyperoxia-induced lung injury. International-journal Peer-reviewed

Chiharu Ota, Kota Ishizawa, Mitsuhiro Yamada, Yukiko Tando, Mei He, Toru Takahashi, Mutsuo Yamaya, Yasuhiko Yamamoto, Hiroshi Yamamoto, Shigeo Kure, Hiroshi Kubo

Respiratory investigation　54　(2)　98-108　2016/03

DOI： 10.1016/j.resinv.2015.08.009 　

ISSN： 2212-5345

eISSN： 2212-5353
先天性気管狭窄を伴うPA slingの一例

矢尾板, 久雄, 木村, 正人, 川合, 英一郎, 大田, 千晴, 和田, 基, 工藤, 博典, 安達, 理, 仁尾, 正記, 齋木, 佳克呉繁夫

日本小児科学会雑誌　120　(2)　364-364　2016
Publisher:
ISSN： 0001-6543
The non-antibiotic macrolide EM900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells. International-journal Peer-reviewed

Nadine Lusamba Kalonji, Kazuhiro Nomura, Tetsuaki Kawase, Chiharu Ota, Hiroshi Kubo, Takeya Sato, Teruyuki Yanagisawa, Toshiaki Sunazuka, Satoshi Ōmura, Mutsuo Yamaya

Physiological reports　3　(10)　2015/10
Publisher: American Physiological Society
DOI： 10.14814/phy2.12557 　

ISSN： 2051-817X
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model. International-journal Peer-reviewed

Yukiko Tando, Chiharu Ota, Mitsuhiro Yamada, Satoshi Kamata, Mutsuo Yamaya, Kuniyuki Kano, Shinichi Okudaira, Junken Aoki, Hiroshi Kubo

Transplantation direct　1　(9)　e35　2015/10

DOI： 10.1097/TXD.0000000000000542 　

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BACKGROUND: Chronic rejection is the major leading cause of morbidity and mortality after lung transplantation. Obliterative bronchiolitis (OB), a fibroproliferative disorder of the small airways, is the main manifestation of chronic lung allograft rejection. However, there is currently no treatment for the disease. We hypothesized that lysophosphatidic acid (LPA) participates in the progression of OB. The aim of this study was to reveal the involvement of LPA on the lesion of OB. METHODS: Ki16198, an antagonist specifically for LPA1 and LPA3, was daily administered into the heterotopic tracheal transplant model mice at the day of transplantation. At days 10 and 28, the allografts were isolated and evaluated histologically. The messenger RNA levels of LPAR in microdissected mouse airway regions were assessed to reveal localization of lysophosphatidic acid receptors. The human airway epithelial cell was used to evaluate the mechanism of LPA-induced suppression of cell adhesion to the extracellular matrix (ECM). RESULTS: The administration of Ki16198 attenuated airway epithelial cell loss in the allograft at day 10. Messenger RNAs of LPA1 and LPA3 were detected in the airway epithelial cells of the mice. Lysophosphatidic acid inhibited the attachment of human airway epithelial cells to the ECM and induced cell detachment from the ECM, which was mediated by LPA1 and Rho-kinase pathway. However, Ki16198 did not prevent obliteration of allograft at day 28. CONCLUSIONS: The LPA signaling is involved in the status of epithelial cells by distinct contribution in 2 different phases of the OB lesion. This finding suggests a role of LPA in the pathogenesis of OB.
FACSによるLAM細胞分離法の確立

安藤克利, 藤野直也, 三谷恵子, 大田千晴, 丹藤由希子, 岡田克典, 近藤丘, 溝渕輝明, 栗原正利, 鈴木健司, 星加義人, 江花弘基, 高橋和久, 久保裕司, 瀬山邦明

日本気胸・嚢胞性肺疾患学会雑誌　15　(1)　85-85　2015/07
Publisher: 日本気胸・嚢胞性肺疾患学会
ISSN： 1883-0412
Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. International-journal Peer-reviewed

Guilian Sun, Chiharu Ota, Setsuko Kitaoka, Yoko Chiba, Masaru Takayanagi, Taro Kitamura, Katsuya Yamamoto, Hiromi Fujie, Hitoshi Mikami, Mitsugu Uematsu, Naomi Hino-Fukuyo, Mitsutoshi Munakata, Shigeo Kure, Kazuhiro Haginoya

Journal of the neurological sciences　349　(1-2)　190-5　2015/02/15

DOI： 10.1016/j.jns.2015.01.017 　

ISSN： 0022-510X

eISSN： 1878-5883
Magnitude of influenza virus replication and cell damage is associated with interleukin-6 production in primary cultures of human tracheal epithelium. International-journal Peer-reviewed

Mutsuo Yamaya, Lusamba K Nadine, Chiharu Ota, Hiroshi Kubo, Tomonori Makiguchi, Ryoichi Nagatomi, Hidekazu Nishimura

Respiratory physiology & neurobiology　202　16-23　2014/10/01

DOI： 10.1016/j.resp.2014.07.010 　

ISSN： 1569-9048

eISSN： 1878-1519
c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs. International-journal Peer-reviewed

Takaya Suzuki, Satoshi Suzuki, Naoya Fujino, Chiharu Ota, Mitsuhiro Yamada, Takashi Suzuki, Mutsuo Yamaya, Takashi Kondo, Hiroshi Kubo

American journal of physiology. Lung cellular and molecular physiology　306　(9)　L855-65-L865　2014/05/01

DOI： 10.1152/ajplung.00211.2013 　

ISSN： 1040-0605

eISSN： 1522-1504
Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. International-journal Peer-reviewed

Mutsuo Yamaya, Hidekazu Nishimura, Lusamba Kalonji Nadine, Chiharu Ota, Hiroshi Kubo, Ryoichi Nagatomi

Archives of pharmacal research　37　(4)　520-9　2014/04

DOI： 10.1007/s12272-013-0210-7 　

ISSN： 0253-6269

eISSN： 1976-3786
Annual FEV1 changes and numbers of circulating endothelial microparticles in patients with COPD: a prospective study. International-journal Peer-reviewed

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Yukiko Tando, Mitsuhiro Yamada, Masaru Yanai, Mutsuo Yamaya, Shin Kurosawa, Masanori Yamauchi, Hiroshi Kubo

BMJ open　4　(3)　e004571　2014/03/06

DOI： 10.1136/bmjopen-2013-004571 　

ISSN： 2044-6055
The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells. International-journal Peer-reviewed

Mitsuhiro Yamada, Hiroshi Kubo, Chiharu Ota, Toru Takahashi, Yukiko Tando, Takaya Suzuki, Naoya Fujino, Tomonori Makiguchi, Kiyoshi Takagi, Takashi Suzuki, Masakazu Ichinose

Respiratory research　14　95-95　2013/09/24

DOI： 10.1186/1465-9921-14-95 　

ISSN： 1465-993X

eISSN： 1465-9921
The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells Peer-reviewed

Mitsuhiro Yamada, Hiroshi Kubo, Chiharu Ota, Toru Takahashi, Yukiko Tando, Takaya Suzuki, Naoya Fujino, Tomonori Makiguchi, Kiyoshi Takagi, Takashi Suzuki, Masakazu Ichinose

Respiratory Research　14　(1)　95　2013/09/24

DOI： 10.1186/1465-9921-14-95 　

ISSN： 1465-9921

eISSN： 1465-993X
Differences in the released endothelial microparticle subtypes between human pulmonary microvascular endothelial cells and aortic endothelial cells in vitro Peer-reviewed

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Yukiko Tando, Mei He, Mitsuhiro Yamada, Shin Kurosawa, Mutsuo Yamaya, Hiroshi Kubo

EXPERIMENTAL LUNG RESEARCH　39　(4-5)　155-161　2013/05

DOI： 10.3109/01902148.2013.784932 　

ISSN： 0190-2148

eISSN： 1521-0499
Increased severity of 2009 pandemic influenza A virus subtype H1N1 infection in alveolar type II cells from patients with pulmonary fibrosis. International-journal Peer-reviewed

Naoya Fujino, Hiroshi Kubo, Chiharu Ota, Takaya Suzuki, Toru Takahashi, Mitsuhiro Yamada, Satoshi Suzuki, Takashi Kondo, Ryouichi Nagatomi, Yukiko Tando, Mutsuo Yamaya

The Journal of infectious diseases　207　(4)　692-3　2013/02/15

DOI： 10.1093/infdis/jis739 　

ISSN： 0022-1899
Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility. International-journal Peer-reviewed

Toru Takahashi, Seiichi Kobayashi, Naoya Fujino, Takaya Suzuki, Chiharu Ota, Mei He, Mitsuhiro Yamada, Satoshi Suzuki, Masaru Yanai, Shin Kurosawa, Mutsuo Yamaya, Hiroshi Kubo

Thorax　67　(12)　1067-74　2012/12

DOI： 10.1136/thoraxjnl-2011-201395 　

ISSN： 0040-6376
Surgical stress increases circulating endothelial microparticles in the elderly Peer-reviewed

T. Takahashi, H. Kim, N. Fujino, T. Suzuki, C. Ota, M. Yamada, M. Yamaya, S. Suzuki, S. Kurosawa

ANAESTHESIA AND INTENSIVE CARE　40　(5)　899-902　2012/09

ISSN： 0310-057X
Analysis of gene expression profiles in alveolar epithelial type II-like cells differentiated from human alveolar epithelial progenitor cells. International-journal Peer-reviewed

Naoya Fujino, Chiharu Ota, Takaya Suzuki, Satoshi Suzuki, Ahmed E Hegab, Mitsuhiro Yamada, Toru Takahashi, Mei He, Takashi Kondo, Hidemasa Kato, Mutsuo Yamaya, Hiroshi Kubo

Respiratory investigation　50　(3)　110-6　2012/09

DOI： 10.1016/j.resinv.2012.07.002 　

ISSN： 2212-5345
A novel method for isolating individual cellular components from the adult human distal lung. International-journal Peer-reviewed

Naoya Fujino, Hiroshi Kubo, Chiharu Ota, Takaya Suzuki, Satoshi Suzuki, Mitsuhiro Yamada, Toru Takahashi, Mei He, Takashi Suzuki, Takashi Kondo, Mutsuo Yamaya

American journal of respiratory cell and molecular biology　46　(4)　422-30　2012/04

DOI： 10.1165/rcmb.2011-0172OC 　

ISSN： 1044-1549
Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice. International-journal Peer-reviewed

Naoya Fujino, Hiroshi Kubo, Tomoko Suzuki, Mei He, Takaya Suzuki, Mitsuhiro Yamada, Toru Takahashi, Chiharu Ota, Mutsuo Yamaya

Experimental lung research　38　(1)　28-36　2012/02

DOI： 10.3109/01902148.2011.633306 　

ISSN： 0190-2148
Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case-control study. International-journal Peer-reviewed

Naoya Fujino, Chiharu Ota, Toru Takahashi, Takaya Suzuki, Satoshi Suzuki, Mitsuhiro Yamada, Ryouichi Nagatomi, Takashi Kondo, Mutsuo Yamaya, Hiroshi Kubo

BMJ open　2　(6)　2012

DOI： 10.1136/bmjopen-2012-001553 　

eISSN： 2044-6055
Isolation of alveolar epithelial type II progenitor cells from adult human lungs. International-journal Peer-reviewed

Naoya Fujino, Hiroshi Kubo, Takaya Suzuki, Chiharu Ota, Ahmed E Hegab, Mei He, Satoshi Suzuki, Takashi Suzuki, Mitsuhiro Yamada, Takashi Kondo, Hidemasa Kato, Mutsuo Yamaya

Laboratory investigation; a journal of technical methods and pathology　91　(3)　363-78　2011/03

DOI： 10.1038/labinvest.2010.187 　

ISSN： 0023-6837
Small-cell lung cancer arising after chemotherapy for a patient with lymphoma of pulmonary mucosa-associated lymphoid tissue-a case report.

Makoto Nakao, Tetsuya Oguri, Ken Maeno, Shigeru Kusumoto, Chiharu Ota, Osamu Takakuwa, Takehiro Uemura, Hiroaki Ozasa, Yasuhito Iwashima, Mikinori Miyazaki, Takeo Kutsuna, Atsushi Nakamura, Hiroshi Inagaki, Shigeki Sato, Ryuzo Ueda

Gan to kagaku ryoho. Cancer & chemotherapy　36　(10)　1711-4　2009/10

ISSN： 0385-0684

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A 76-year-old woman was admitted to our hospital with infiltrations evident in the right lower lobe on chest computed tomography. Bronchoscopic biopsy showed lymphoma of mucosa-associated lymphoid tissue (MALT). Lymphoma of the pulmonary MALT became enlarged at 8 months after diagnosis and dyspnea developed. Four courses of chemotherapy(rituximab+ cladribine)resulted in a partial response. However, 14 months after the chemotherapy, she developed multiple lung and liver tumors accompanied by disseminated intravascular coagulation syndrome. A histological examination of bone marrow aspiration showed small cell carcinoma. We administered one course of carboplatin and etoposide, but bone marrow suppression was so severe that further chemotherapy was precluded. To our knowledge, this is a rare case of small cell lung cancer arising from the treatment of lymphoma of pulmonary MALT.
Endobronchial metastasis from primary papillary serous carcinoma of the peritoneum.

Makoto Nakao, Tetsuya Oguri, Ken Maeno, Chiharu Ota, Osamu Takakuwa, Yasuhito Iwashima, Mikinori Miyazaki, Takeo Kutsuna, Atsushi Nakamura, Shigeki Sato, Ryuzo Ueda

Internal medicine (Tokyo, Japan)　48　(13)　1165-8　2009

eISSN： 1349-7235

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A 59-year-old woman was admitted to our hospital with a left lower lobe opacity and mediastinal shift on the chest X-ray. She had been complaining of intermittent nonproductive cough and exertional dyspnea. Chest computed tomography (CT) showed an endobronchial tumor of the left main to the lower bronchus, atelectasis of the left lower lobe, and mediastinal shift. Bronchoscopy revealed a polypoid tumor at the distal portion of the left main bronchus that occluded the bronchus. Biopsy specimens from the endobronchial tumor were shown to be serous papillary adenocarcinoma. Since the patient had been treated surgically for primary papillary serous carcinoma of the peritoneum (PSCP) 10 years earlier, immunohistochemical examinations were performed. The diagnosis of endobronchial metastasis of PSCP was confirmed by immunohistochemical staining with cancer antigen 125 (CA125), vimentin, and Wilms tumor-1 (WT-1). This is a rare case of endobronchial metastasis from PSCP.
【小児周術期管理の諸問題】小児の麻酔導入法

大田千晴, 谷口晃啓

麻酔　56　(5)　516-525　2007/05
Publisher: 克誠堂出版(株)
ISSN： 0021-4892
[Induction of general anesthesia in pediatric patients]. Peer-reviewed

Chiharu Ota, Akihiro Taniguchi

Masui. The Japanese journal of anesthesiology　56　(5)　516-25　2007/05

ISSN： 0021-4892
Anesthetic management of bidirectional cavopulmonary shunt in a patient with pulmonary atresia with intact ventricular septum associated with sinusoidal communications. Peer-reviewed

Yoshitaka Kawaraguchi, Akihiro Taniguchi, Tomoko Otomo, Chiharu Ota, Naoko Uchida

Journal of anesthesia　20　(3)　220-2　2006

DOI： 10.1007/s00540-006-0395-8 　

ISSN： 0913-8668
【小児救急の勘どころ】頻度の高い小児救急疾患熱性疾患生後3ヵ月未満児の発熱にどう対処するか

大田千晴

救急医学　29　(12)　1663-1667　2005/11
Publisher: (株)へるす出版
ISSN： 0385-8162
患者指導用リーフレットに対する保護者の考え方

石井博子, 田中哲郎, 市川光太郎, 大田千晴, 山田至康, 津田文史朗

日本小児救急医学会雑誌　4　(1)　135-137　2005/07
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162

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Misc. 98

The Effects of Environments, especially Passive Smoking, on Blood Pressure in Toddlers

KANAMORI Keita, KANAMORI Keita, 鈴木智尚, 大田千晴, 大田千晴, 大田千晴

日本小児科学会雑誌　129　(2)　2025

ISSN： 0001-6543
心不全多職種カンファランスの実践成人先天性心疾患診療における多職種連携

建部俊介, 山本沙織, 佐藤遥, 梶川アユミ, 林秀華, 佐藤大樹, 鈴木秀明, 矢尾板信裕, 後岡広太郎, 高濱博幸, 白戸崇, 矢尾板久雄, 大田千晴, 齋木佳克, 安田聡

日本心臓病学会学術集会抄録　72回　PD1-5　2024/09
Publisher: (一社)日本心臓病学会
育児期に新規発症した父親の産後うつリスク

鈴木妙子, 鈴木妙子, 西郡俊絵, 小原拓, 小原拓, 小原拓, 櫻井香澄, 石黒真美, 石黒真美, 濱田裕貴, 渡邉善, 齋藤昌利, 大田千晴, 有馬隆博, 目時弘仁, 栗山進一, 栗山進一, 栗山進一, 八重樫伸生, 八重樫伸生, 西郡秀和, 西郡秀和

日本周産期メンタルヘルス学会学術集会プログラム・抄録集　20th　2024
自閉スペクトラム症の児に対する養育者の態度-エコチル調査より-

金森啓太, 金森啓太, 鈴木智尚, 大田千晴, 大田千晴

東北公衆衛生学会講演集　73rd (CD-ROM)　2024

ISSN： 0915-549X
妊娠前から育児期における母親の身体活動と幼児期の子どもの身体活動の関連エコチル調査宮城ユニットセンターによる追加調査

山田綾, 門間陽樹, 龍田希, 仲井邦彦, 有馬隆博, 大田千晴, 八重樫伸生, 永富良一, 永富良一

日本発育発達学会大会プログラム・抄録集(Web)　22nd　2024
乳幼児の肺発達とSIDS

大田千晴

日本SIDS・乳幼児突然死予防学会学術集会抄録集　29th　2024
こどもの健康と環境の影響を考える-エコチル調査でなにがわかるか-

大田千晴, 大田千晴

日本小児科学会雑誌　128　(8)　2024

ISSN： 0001-6543
顕著な消化器症状から腸炎として加療された川崎病の1例

宍戸悠華, 池田麻衣子, 岩渕蒼太, 大田千晴, 星菜美子, 岩澤伸哉

日本小児科学会雑誌　128　(8)　2024

ISSN： 0001-6543
当院におけるプロピオン酸血症患者16症例の検討と心機能低下を認めた2例の経過

矢尾板久雄, 星菜美子, 岩澤伸哉, 大田千晴

日本小児循環器学会総会・学術集会(Web)　60th　2024
Noonan症候群患者の自然歴についての検討

大田千晴, 岩澤伸哉, 矢尾板久雄, 星菜美子

日本小児循環器学会総会・学術集会(Web)　60th　2024
小児心電図の疫学研究幼児期の心電図健診実施の意義の検討

岩澤伸哉, 大軒健彦, 大田千晴, 川合英一郎, 新田恩, 田中高志, 木村正人

日本小児循環器学会総会・学術集会抄録集　59回　[I-08]　2023/07
Publisher: (NPO)日本小児循環器学会
小児がん患者の初回治療における心血管障害の検討

星菜美子, 岩澤伸哉, 大田千晴

日本小児循環器学会総会・学術集会抄録集　59回　[II-08]　2023/07
Publisher: (NPO)日本小児循環器学会
フォンタン関連肝疾患追跡におけるGd-EOB-DTPAを用いた造影MRIの有用性の検討

大田千晴, 岩澤伸哉, 大軒健彦, 星菜美子

日本小児循環器学会総会・学術集会抄録集　59回　[III-07]　2023/07
Publisher: (NPO)日本小児循環器学会
肺血栓塞栓症、深部静脈血栓症で発症し、リバーロキサバンで治療した先天性アンチトロンビン欠乏症の一例

森ひろみ, 星菜美子, 大田千晴, 岩澤伸哉

日本小児循環器学会総会・学術集会抄録集　59回　[III-03]　2023/07
Publisher: (NPO)日本小児循環器学会
小児救急in Tohoku Digital transformationで東北の小児救急課題解決を目指す

大田千晴

日本小児科学会雑誌　127　(4)　645-646　2023/04
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
広範囲の深部静脈血栓塞栓症を合併した小児潰瘍性大腸炎の1例

成重勇太, 加藤歩, 星雄介, 角田文彦, 星菜美子, 岩澤伸哉, 大田千晴, 虻川大樹

日本小児栄養消化器肝臓学会雑誌　37　(1)　50-50　2023/04
Publisher: (一社)日本小児栄養消化器肝臓学会
ISSN： 1346-9037
COVID-19流行の小児科専門研修への影響

内田奈生, 大田千晴, 和田陽一, 岩澤伸哉, 笹原洋二, 呉繁夫

日本小児科学会雑誌　127　(2)　294-294　2023/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
小児コロナワクチン後副反応についての検討塩釜市立病院におけるアンケート調査の結果から

大田千晴, 森谷邦彦, 池田秀之, 渡邊真平, 菊池敦生, 佐藤園子, 川村順子, 森本哲司

日本小児科学会雑誌　126　(12)　1657-1657　2022/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
医療トラウマに対しChild Life Specialistによる支援が有効であった4歳女児の1例

渡辺悠, 大田千晴, 笹原洋二

日本小児科学会雑誌　126　(12)　1657-1658　2022/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
ステントグラフト挿入により大動脈縮窄術後の遠隔期狭窄が改善した12歳女児例

大田千晴, 鈴木佑輔, 岩澤伸哉, 大軒健彦, 松尾諭志, 齋木佳克

日本小児循環器学会総会・学術集会抄録集　58回　[III-08]　2022/07
Publisher: (NPO)日本小児循環器学会
カルシウム拮抗薬が奏効した左脚後枝起源特発性心室頻拍の1例

白石直広, 大田千晴, 大軒健彦, 岩澤伸哉, 呉繁夫

日本小児科学会雑誌　126　(5)　845-845　2022/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
川崎病に対する血漿交換療法の効果

黒田薫, 大田千晴, 大軒健彦, 岩澤伸哉

日本アフェレシス学会雑誌　40　(Suppl.)　119-119　2021/10
Publisher: (一社)日本アフェレシス学会
ISSN： 1340-5888
東北大学病院小児科における川崎病に対する血漿交換療法の効果についての検討

黒田薫, 大田千晴, 大軒健彦, 岩澤伸哉

日本小児循環器学会総会・学術集会抄録集　57回　[P43-6]　2021/07
Publisher: (NPO)日本小児循環器学会
慢性呼吸不全に対し非侵襲的陽圧換気が奏功した11歳女児

八木耕平, 大田千晴, 黒田薫, 大軒健彦, 岩澤伸哉, 平間崇, 岡田克典

日本小児科学会雑誌　125　(5)　834-834　2021/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
当院における川崎病に対する血漿交換療法の効果についての検討

黒田薫, 大田千晴, 大軒健彦, 岩澤伸哉

日本小児科学会雑誌　125　(5)　834-835　2021/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
当院でフォローしている成人期に達した修正大血管転位症の検討

六郷由佳, 岩澤伸哉, 大軒健彦, 大田千晴, 木村正人, 建部俊介

日本小児循環器学会雑誌　36　(Suppl.2)　s2-226　2020/11
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
当院小児科および循環器内科でフォロー中の異なる年齢層の成人期Eisenmenger症候群症例の検討

大田千晴, 岩澤伸哉, 大軒健彦, 建部俊介, 木村正人, 六郷由佳

日本小児循環器学会雑誌　36　(Suppl.2)　s2-340　2020/11
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
当院でフォローしている成人期に達した修正大血管転位症の検討

六郷由佳, 岩澤伸哉, 大軒健彦, 大田千晴, 木村正人, 建部俊介

日本小児循環器学会雑誌　36　(Suppl.2)　s2-226　2020/11
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
当院小児科および循環器内科でフォロー中の異なる年齢層の成人期Eisenmenger症候群症例の検討

大田千晴, 岩澤伸哉, 大軒健彦, 建部俊介, 木村正人, 六郷由佳

日本小児循環器学会雑誌　36　(Suppl.2)　s2-340　2020/11
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
組織幹細胞保存液の開発とヒト組織への応用

鈴木隆哉, 大田千晴, 藤野直也, 丹藤由紀子, 山田充啓, 鈴木聡, 岡田克典, 久保裕司

日本再生医療学会総会(Web)　19th　2020
テレメトリー式心電送信機(Duranta)の小児に対する使用経験

木村正人, 高橋明則, 岡庭貴志, 大田千晴, 岩澤伸哉

日本小児循環器学会雑誌　35　(Suppl.1)　s1-247　2019/06
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
WPW症候群に伴う心機能低下におけるリスク予測因子の検討

木村正人, 福田浩二, 杉本寛之, 中野誠, 大田千晴, 岩澤伸哉

日本小児循環器学会雑誌　35　(Suppl.1)　s1-249　2019/06
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
超早産児で出生し、慢性肺疾患および肺高血圧に対して両側肺移植を行った1例

岩澤伸哉, 木村正人, 大田千晴, 松田安史, 岡田克典, 呉繁夫

日本小児循環器学会雑誌　35　(Suppl.1)　s1-423　2019/06
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
拡張型心筋症との鑑別を要した頻脈誘発性心筋症の1例

加納伸介, 木村正人, 福田浩二, 大田千晴, 川野研悟, 呉繁夫

日本小児科学会雑誌　123　(3)　644-644　2019/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
軽症の肥大型心筋症にも関わらず院外心停止をきたした16歳例

六郷由佳, 木村正人, 大田千晴, 目時嵩也, 川野研悟, 遠藤若葉, 呉繁夫

日本小児科学会雑誌　123　(3)　644-644　2019/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
ゲームセンターで植込み型除細動器が電磁干渉を受けた幼児

木村正人, 川合英一郎, 大田千晴, 呉繁夫

日本小児科学会雑誌　123　(3)　587-590　2019/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
肺高血圧を伴った新生児慢性肺疾患(bronchopulmonary dysplasia)に対する脳死両側肺移植の経験

松田安史, 大田千晴, 木村正人, 大石久, 平間崇, 佐渡哲, 野田雅史, 桜田晃, 秋場美紀, 呉繁夫, 安達理, 齋木佳克, 岡田克典

日本肺および心肺移植研究会プログラム・抄録集　35th　2019
慢性肺疾患に合併した肺高血圧に対し肺血管拡張薬投与が有効であった2例

大田千晴, 木村正人, 呉繁夫

日本小児呼吸器学会雑誌　29　(Suppl.)　151-151　2018/08
Publisher: 日本小児呼吸器学会
ISSN： 2187-5731
心機能低下を合併した無症候性WPW症候群に対するアブレーション治療

木村正人, 福田浩二, 中野誠, 川野研悟, 大田千晴, 呉繁夫

日本小児循環器学会雑誌　34　(Suppl.1)　s1-178　2018/07
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
当院で肺動脈弁置換前後にMRIを施行したFallot四徴症の検討

高橋怜, 木村正人, 川野研悟, 大田千晴, 大田英揮, 安達理, 斎木佳克, 呉繁夫

日本小児循環器学会雑誌　34　(Suppl.1)　s1-262　2018/07
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
ゲームセンターで植込み型デバイスが電磁干渉を受けた4歳女児例

木村正人, 川野研悟, 大田千晴, 高橋怜, 呉繁夫

日本小児循環器学会雑誌　34　(Suppl.1)　s1-276　2018/07
Publisher: (NPO)日本小児循環器学会
ISSN： 0911-1794

eISSN： 2187-2988
心機能低下を合併したWPW症候群に対するカテーテルアブレーション治療

木村正人, 川野研悟, 大田千晴, 遠藤早紀, 山口祐樹, 呉繁夫, 福田浩二

日本小児科学会雑誌　122　(6)　1106-1106　2018/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
神経線維腫症1型に高血圧を合併した2症例

山口祐樹, 木村正人, 川野研悟, 大田千晴, 呉繁夫, 大浦敏博, 小林朋子, 高瀬圭

日本小児科学会雑誌　122　(6)　1106-1106　2018/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
心機能低下を合併したWPW症候群に対するカテーテルアブレーション治療

木村正人, 川野研悟, 大田千晴, 遠藤早紀, 山口祐樹, 呉繁夫, 福田浩二

日本小児科学会雑誌　122　(6)　1106-1106　2018/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
神経線維腫症1型に高血圧を合併した2症例

山口祐樹, 木村正人, 川野研悟, 大田千晴, 呉繁夫, 大浦敏博, 小林朋子, 高瀬圭

日本小児科学会雑誌　122　(6)　1106-1106　2018/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
急性脳症の経過中にミトコンドリアCK血症を呈した2歳男児例

山村菜絵子, 大田千晴, 矢尾板久雄, 川合英一郎, 木村正人, 植松貢, 呉繁夫, 沼田美香

日本小児科学会雑誌　120　(10)　1552-1552　2016/10
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
胸部レントゲン写真の異常陰影が診断のきっかけとなった2症例

木村正人, 大田千晴, 川合英一郎, 矢尾板久雄, 池田秀之, 呉繁夫, 溝口由美子

日本小児科学会雑誌　120　(10)　1555-1555　2016/10
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
臨床所見に乏しく診断確定に苦慮した不全型川崎病の1乳児例

池田秀之, 木村正人, 矢尾板久雄, 川合英一郎, 大田千晴, 呉繁夫, 溝口由美子

日本小児科学会雑誌　120　(10)　1555-1556　2016/10
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
異物誤飲した発達障害、摂食障害のある7歳男児

川合英一郎, 木村正人, 池田秀之, 矢尾板久雄, 大田千晴, 呉繁夫, 工藤博典, 櫻井毅, 大久保龍二, 中村恵美, 田中拡, 風間理郎, 佐々木英之, 和田基, 仁尾正記

日本小児科学会雑誌　120　(10)　1556-1556　2016/10
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
The Receptor For Advanced Glycation End-Products Of Alveolar Epithelial Cells Is A Key Modulator Of Hyperoxia-Induced Lung Injury

C. Ota, K. Ishizawa, M. Yamada, Y. Tando, H. Mei, T. Takahashi, Y. Yamamoto, H. Yamamoto, M. Yamaya, H. Kubo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　189　2014

ISSN： 1073-449X

eISSN： 1535-4970
Both Mir-21 And Mir-155c Increase In Serum Exosomes During Bleomycin- Induced Lung Injury In Mice

M. Yamada, H. Kubo, S. Kobayashi, C. Ota, T. Takahashi, N. Fujino, T. Suzuki, Y. Tando, M. Yanai, M. Ichinose

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　187　2013

ISSN： 1073-449X

eISSN： 1535-4970
Relationships Between Annual Changes In Fev1 And Numbers Of Circulating Endothelial Microparticles In COPD Patients

T. Takahashi, S. Kobayashi, N. Fujino, T. Suzuki, Y. Tando, C. Ota, M. Yamada, S. Kurosawa, M. Yanai, M. Yamaya, H. Kubo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　187　2013

ISSN： 1073-449X

eISSN： 1535-4970
組織幹細胞保存液StemSurviveの開発

鈴木隆哉, 久保裕司, 藤野直也, 大田千晴, 高橋徹, 岡田克典, 山谷睦雄, 近藤丘

Organ Biology　18　(2)　249-249　2011/10
Publisher: (一社)日本臓器保存生物医学会
DOI： 10.11378/organbio.18.249 　

ISSN： 1340-5152
Cerebro-Costo-Mandibular症候群の2歳男児の麻酔経験

大田千晴, 谷口晃啓, 内田直子, 小野理恵, 小泉沢, 北村征治

日本小児麻酔学会誌　13　(1)　111-111　2007/11
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
左肺無形成、気管狭窄症を合併した右肺分画症の乳児に対する麻酔経験

大田千晴, 谷口晃啓, 内田直子, 小野理恵, 小泉沢, 北村征治

日本小児麻酔学会誌　13　(1)　111-111　2007/11
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
重症先天性気管気管支狭窄症患児に対するY型気管チューブを用いた長期呼吸管理と左主気管支形成術

小泉沢, 谷口晃啓, 内田直子, 大田千晴, 小野理恵, 菅野啓一, 仁尾正記

日本小児麻酔学会誌　13　(1)　113-113　2007/11
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
食道内の開いた安全ピンを内視鏡的に回収した一例

田中拡, 仁尾正記, 佐藤智行, 大井龍司, 谷口晃啓, 大田千晴, 内田直子

日本小児救急医学会雑誌　6　(1)　153-153　2007/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
当院における新生児外科疾患についての検討

大田千晴, 谷口晃啓, 内田直子

日本小児科学会雑誌　111　(4)　620-620　2007/04
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
声門下狭窄症に対し輪状軟骨前方切開術を施行し抜管し得た新生児の1例

大田千晴, 谷口晃啓, 内田直子, 仁尾正記

日本小児科学会雑誌　111　(2)　441-441　2007/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
十二指腸穿孔による汎発性腹膜炎術後に食道穿孔を併発し、深在性真菌感染症の関与が疑われた小児例

大田千晴, 谷口晃啓, 内田直子, 瓦口至孝, 仁尾正記

日本集中治療医学会雑誌　14　(Suppl.)　268-268　2007/01
Publisher: (一社)日本集中治療医学会
ISSN： 1340-7988

eISSN： 1882-966X
左下肢駆血解除後に高カリウム血症をきたし心停止に至った1例

内田直子, 谷口晃啓, 瓦口至孝, 大友知子, 大田千晴

日本小児麻酔学会誌　12　(1)　85-85　2006/09
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
宮城県立こども病院ICUにおける呼吸管理症例の検討

大田千晴, 谷口晃啓, 内田直子

日本小児科学会雑誌　110　(9)　1308-1308　2006/09
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
ICUに入室した新生児心疾患症例の出生前診断と重症度の関係

大田千晴, 谷口晃啓, 内田直子

日本小児救急医学会雑誌　5　(1)　109-109　2006/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
アルブミン製剤によるアナフィラキシーショックが疑われた小児の1症例

大友知子, 瓦口至孝, 谷口晃啓, 大田千晴

麻酔　55　(2)　241-241　2006/02
Publisher: 克誠堂出版(株)
ISSN： 0021-4892
Interleukin-1 receptor-associated kinase 4欠損症に発症した小児の致死的肺炎球菌性髄膜炎の一例

大友知子, 谷口晃啓, 瓦口至孝, 春名純一, 大田千晴, 吉川秀人

日本集中治療医学会雑誌　13　(Suppl.)　189-189　2006/01
Publisher: (一社)日本集中治療医学会
ISSN： 1340-7988

eISSN： 1882-966X
肺炎を契機に食道裂孔ヘルニアの診断に至った7ヵ月男児例

大田千晴, 佐藤徹雄, 仁尾正紀, 佐野信行

日本小児科学会雑誌　109　(10)　1267-1267　2005/10
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
超低出生体重児の気管食道瘻に対する麻酔経験

春名純一, 大田千晴, 瓦口至孝, 大友知子, 谷口晃啓, 菅野啓一

日本小児麻酔学会誌　11　(1)　111-111　2005/09
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
術後腹臥位保持が必要な小児に対する塩酸デクスメデトミジンの効果

大友知子, 谷口晃啓, 瓦口至孝, 春名純一, 大田千晴

日本小児麻酔学会誌　11　(1)　120-120　2005/09
Publisher: (一社)日本小児麻酔学会
ISSN： 1341-5603
公立気仙沼総合病院における搬送症例の検討

大田千晴, 佐藤徹雄

日本小児救急医学会雑誌　4　(1)　70-70　2005/07
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
日齢5に発熱および頸部腫脹にて発症し,診断に至った下咽頭梨状窩瘻の1男児例

大田千晴, 佐藤徹雄, 斉藤潤子, 天江新太郎, 中村潤, 林富

日本小児救急医学会雑誌　4　(1)　84-84　2005/07
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
高カルシウム血症にて発見されたCD19(-)precursor-B ALLの2例

渡邊庸平, 大田千晴, 新妻秀剛, 藤井邦裕, 藤原幾磨, 飯沼一宇, 佐藤篤, 今泉益栄

Clinical Calcium　15　(5)　875-875　2005/04
Publisher: (株)医薬ジャーナル社
ISSN： 0917-5857
十二指腸閉鎖術後に胆道拡張症を発症したダウン症候群の1症例

大田千晴, 渡邊庸平, 藤井邦裕, 飯沼一宇, 中村潤, 木村憲治

日本小児科学会雑誌　109　(3)　418-418　2005/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
【ウイルス感染症】ロタウイルス感染で中枢神経症状を伴った2症例

黒羽根郁夫, 貴田岡節子, 斎藤潤子, 大田千晴, 萩野谷和裕

小児科臨床　58　(2)　209-213　2005/02
Publisher: (株)総合医学社
ISSN： 0021-518X
化学療法後に多発性結節性脂肪織炎を合併したAML(M4)の一例

藤井邦裕, 渡邊庸平, 大田千晴, 古賀晋一郎, 今泉益栄, 飯沼一宇

小児がん　41　(3)　752-752　2004/11
Publisher: (NPO)日本小児がん学会
ISSN： 0389-4525
EBウイルス初感染時の顆粒球減少症の頻度とその発症時期

西村奈穂, 大田千晴, 神薗淳司, 市川光太郎

小児がん　41　(3)　756-756　2004/11
Publisher: (NPO)日本小児がん学会
ISSN： 0389-4525
水痘罹患時の重症細菌感染合併症例の検討

西村奈穂, 神薗淳司, 天本正乃, 市川光太郎, 大田千晴

日本小児科学会雑誌　108　(8)　1083-1083　2004/08
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
化学療法後に多発性結節性脂肪織炎を合併したAML(M4)の一例

藤井邦裕, 渡邊庸平, 大田千晴, 古賀晋一郎, 今泉益栄, 飯沼一宇

日本小児血液学会雑誌　18　(4)　491-491　2004/08
Publisher: 日本小児血液学会
ISSN： 0913-8706
EBウイルス初感染時の顆粒球減少症の頻度とその発症時期

西村奈穂, 大田千晴, 神薗淳司, 市川光太郎

日本小児血液学会雑誌　18　(4)　495-495　2004/08
Publisher: 日本小児血液学会
ISSN： 0913-8706
当院における外傷性膵損傷症例の臨床的検討外傷性肝損傷症例との比較検討

田村卓也, 神薗淳司, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(6)　902-902　2004/06
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
腹部の鈍的外傷当院における外傷性膵損傷症例の臨床的検討外傷性肝損傷症例との比較検討

田村卓也, 神薗淳司, 天本正乃, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 市川光太郎

日本小児救急医学会雑誌　3　(1)　58-58　2004/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
CTにて術前診断し得たWinslow孔ヘルニアの9歳男児例

大田千晴, 天本正乃, 神薗淳司, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 市川光太郎, 伊藤重彦

日本小児救急医学会雑誌　3　(1)　102-102　2004/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
CRS(保護装置チャイルドシート)装着に関するアンケート調査結果乳児用CRSの「前向き」装着は危険である

山根浩昌, 神薗淳司, 大田千晴, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児救急医学会雑誌　3　(1)　108-108　2004/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
細菌性髄膜炎を繰り返した先天性皮膚洞の乳児例

中山知則, 神薗淳司, 酒井文宣, 田村卓也, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎, 諸藤陽一, 岩永充人, 辻村雅樹

日本小児科学会雑誌　108　(5)　831-831　2004/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
肝中心静脈閉塞症に対する持続血液濾過透析・持続血漿交換療法

神薗淳司, 森下高弘, 酒井文宜, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(3)　471-471　2004/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
外傷性十二指腸壁内血腫の10歳男児例

森下高弘, 神薗淳司, 酒井文宜, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(3)　472-472　2004/03
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Helicobacter pylori感染症とHenoch-Schonlein purpura

神薗淳司, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(2)　288-288　2004/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
顆粒球減少を合併したEBウイルス感染症の臨床像とその機序

大田千晴, 神薗淳司, 北村知宏, 山根浩昌, 堤隆博, 今村徳夫, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(2)　302-302　2004/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
乳児用保護装置シートの「前向き」装着は危険である装着状況アンケート調査結果

山根浩昌, 神薗淳司, 大田千晴, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　108　(2)　341-341　2004/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
ロタウイルス感染で中枢神経症状を伴った2症例

黒羽根郁夫, 貴田岡節子, 斉藤潤子, 大田千晴, 萩野谷和裕

日本小児科学会雑誌　108　(1)　102-103　2004/01
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
顆粒球減少を合併したEBウイルス感染症の臨床像とその機序

神薗淳司, 北村知宏, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本化学療法学会雑誌　51　(12)　799-799　2003/12
Publisher: (公社)日本化学療法学会
ISSN： 1340-7007

eISSN： 1884-5886
腹部CTで術前診断し得たWinslow孔ヘルニアの10歳男児例

草野総子, 天本正乃, 神薗淳司, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 市川光太郎, 木戸川秀生, 伊藤重彦

日本小児科学会雑誌　107　(12)　1690-1690　2003/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
HHV-6による突発性発疹症を契機に診断したシトルリン血症II型の2ヵ月乳児例

大田千晴, 神薗淳司, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎, 小林圭子, 佐伯無頼, 田澤雄作

日本小児科学会雑誌　107　(12)　1690-1691　2003/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
無顆粒球症を合併したEBウイルス感染症の2例

北村知宏, 神薗淳司, 大田千晴, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　107　(12)　1691-1691　2003/12
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
著明な腎浸潤を認めた進行神経芽腫の2歳男児例

大田千晴, 神薗淳司, 市川光太郎

小児がん　40　(3)　470-470　2003/11
Publisher: (NPO)日本小児がん学会
ISSN： 0389-4525
チャイルドシート誤着用により硬膜下水腫をきたした5ヵ月乳児例

原宗嗣, 神薗淳司, 冨岡志保, 北村知宏, 森下高広, 大田千晴, 服部圭太, 山根浩昌, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児科学会雑誌　107　(8)　1123-1123　2003/08
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
当院におけるRSウイルス感染症について

大田千晴, 貴田岡節子, 黒羽根郁夫, 斎藤潤子, 市川光太郎, 神園淳司

日本小児救急医学会雑誌　2　(1)　101-101　2003/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
当院における急性巣状細菌性腎炎5症例の検討

山根浩昌, 神薗淳司, 服部圭太, 岡松由記, 大田千晴, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児救急医学会雑誌　2　(1)　115-115　2003/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162
両側水腎水尿管症例に合併した偽性Bartter症候群の10歳男児例

大田千晴, 神薗淳司, 堤隆博, 今村徳夫, 石橋紳作, 天本正乃, 市川光太郎

日本小児救急医学会雑誌　2　(1)　116-116　2003/06
Publisher: (一社)日本小児救急医学会
ISSN： 1346-8162

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Books and Other Publications 1

内科医・小児科研修医のための小児救急治療ガイドライン

市川, 光太郎

診断と治療社　2007/10

ISBN: 9784787815859

Presentations 24

ゲームセンターで植込み型除細動器が電磁干渉を受けた幼児

木村正人, 川合英一郎, 大田千晴, 呉繁夫

日本小児科学会雑誌　2019/03

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4歳女児。生後5ヵ月時に誘引なく自宅で心肺停止となり、最終的に左室緻密化障害による致死性不整脈がその原因と診断された。蘇生後の二次予防として7ヵ月時に左腹部へICD植込み術を施行し、右室ペーシングが行われたが、その後も同期不全による心不全の悪化を認めたため、16ヵ月時にCRT-Dにアップグレードし、両心ペーシングが行われた。以後、3年間は除細動の作動なく、回復していたが、今回、月1回のホームモニタリングシステムの記録で、1秒程度のハイレートエピソードが送信され、電磁干渉を受けていることに気づいた。そこで、保護者への行動調査を行ったところ、父親とゲームセンターで30分ほど過ごしていたことが判明し、これが植込み型デバイスへ影響したものと推察された。
軽症の肥大型心筋症にも関わらず院外心停止をきたした16歳例

六郷由佳, 木村正人, 大田千晴, 目時嵩也, 川野研悟, 遠藤若葉, 呉繁夫

日本小児科学会雑誌　2019/03
拡張型心筋症との鑑別を要した頻脈誘発性心筋症の1例

加納伸介, 木村正人, 福田浩二, 大田千晴, 川野研悟, 呉繁夫

日本小児科学会雑誌　2019/03
慢性肺疾患に合併した肺高血圧に対し肺血管拡張薬投与が有効であった2例

大田千晴, 木村正人, 呉繁夫

日本小児呼吸器学会雑誌　2018/08
神経線維腫症1型に高血圧を合併した2症例

山口祐樹, 木村正人, 川野研悟, 大田千晴, 呉繁夫, 大浦敏博, 小林朋子, 高瀬圭

日本小児科学会雑誌　2018/06
心機能低下を合併したWPW症候群に対するカテーテルアブレーション治療

木村正人, 川野研悟, 大田千晴, 遠藤早紀, 山口祐樹, 呉繁夫, 福田浩二

日本小児科学会雑誌　2018/06
異物誤飲した発達障害、摂食障害のある7歳男児

川合英一郎, 木村正人, 池田秀之, 矢尾板久雄, 大田千晴, 呉繁夫, 工藤博典, 櫻井毅, 大久保龍二, 中村恵美, 田中拡, 風間理郎, 佐々木英之, 和田基, 仁尾正記

日本小児科学会雑誌　2016/10
臨床所見に乏しく診断確定に苦慮した不全型川崎病の1乳児例

池田秀之, 木村正人, 矢尾板久雄, 川合英一郎, 大田千晴, 呉繁夫, 溝口由美子

日本小児科学会雑誌　2016/10
胸部レントゲン写真の異常陰影が診断のきっかけとなった2症例

木村正人, 大田千晴, 川合英一郎, 矢尾板久雄, 池田秀之, 呉繁夫, 溝口由美子

日本小児科学会雑誌　2016/10
急性脳症の経過中にミトコンドリアCK血症を呈した2歳男児例

山村菜絵子, 大田千晴, 矢尾板久雄, 川合英一郎, 木村正人, 植松貢, 呉繁夫, 沼田美香

日本小児科学会雑誌　2016/10
進行性の心伝導障害に対して予防的にペースメーカー植込みを施行したカーンズ・セイヤー症候群の13歳例

木村正人, 大田千晴, 川合英一郎, 矢尾板久雄, 山村菜絵子, 呉繁夫, 小林朋子, 近藤正輝

日本小児科学会雑誌　2016/05
FACSによるLAM細胞分離法の確立

安藤克利, 藤野直也, 大田千晴, 岡田克典, 栗原正利, 江花弘基, 高橋和久, 久保裕司, 瀬山邦明

日本呼吸器学会誌　2016/03
特発性肺線維症の予後予測因子としての血清エクソソームmicroRNA

牧口友紀, 山田充啓, 吉岡祐亮, 杉浦久敏, 小荒井晃, 大田千晴, 久保裕司, 小林誠一, 矢内勝, 志村早苗, 一ノ瀬正和

日本呼吸器学会誌　2016/03
先天性気管狭窄を伴うPA slingの一例

矢尾板久雄, 木村正人, 川合英一郎, 大田千晴, 和田基, 工藤博典, 安達理, 仁尾正記, 齋木佳克, 呉繁夫

日本小児科学会雑誌　2016/02
A NOVEL METHOD OF ISOLATING INDIVIDUAL CELLS FROM LUNG LESIONS OF LYMPHANGIOLEIOMYOMATOSIS

Katsutoshi Ando, Naoya Fujino, Keiko Mitani, Chiharu Ota, Yoshinori Okada, Takashi Kondo, Teruaki Mizobuchi, Masatoshi Kurihara, Kenji Suzuki, Yoshito Hoshika, Hiroki Ebana, Etsuko Kobayashi, Hiroshi Kubo, Kuniaki Seyama, Kazuhisa Takahashi

RESPIROLOGY　2015/12
FACSによるLAM細胞分離法の確立

安藤克利, 藤野直也, 三谷恵子, 大田千晴, 丹藤由希子, 岡田克典, 近藤丘, 溝渕輝明, 栗原正利, 鈴木健司, 星加義人, 江花弘基, 高橋和久, 久保裕司, 瀬山邦明

日本気胸・嚢胞性肺疾患学会雑誌　2015/07
Disease-Specific Cellular Proportion Pattern Of Combined Pulmonary Fibrosis And Emphysema (cpfe)

C. Ota, Y. Tando, S. Kamata, M. Yamada, K. Ichikado, S. Suzuki, N. Fujino, M. Yamaya, H. Kubo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2015
Isolation Of Pulmonary Lymphangioleiomyomatosis Cells Using A New Anti-Podoplanin Antibody

S. Kamata, H. Kubo, Y. Kato, M. Kaneko, S. Ogasawara, Y. Tando, C. Ota, M. Yamada, M. Yamaya, T. Kondo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2015
Autotaxin Inhibition Attenuated Bronchiolitis Obliterans In A Murine Heterotopic Tracheal Transplant Model

Y. Tando, C. Ota, M. Yamada, T. Takahashi, M. Yamaya, S. Okudaira, J. Aoki, H. Kubo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2013
Identification And Characteristics Of Lung Alveolar Epithelial Label-Retaining Cells

M. Yamada, H. Kubo, N. Fujino, T. Takahashi, C. Ota, T. Suzuki, Y. Tando, M. Ichinose

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2013
組織幹細胞保存液StemSurviveの開発

鈴木隆哉, 久保裕司, 藤野直也, 大田千晴, 高橋徹, 岡田克典, 山谷睦雄, 近藤丘

Organ Biology　2011/10
A Novel Differentiation Assay System For Human Alveolar Epithelial Type II Cells From Alveolar Epithelial Stem/Progenitor Cells In Vitro

C. Ota, N. Fujino, T. Suzuki, M. He, S. Suzuki, M. Yamada, T. Kondo, H. Kato, M. Yamaya, H. Kubo

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2011
Expression Patterns Of Two Important Regulatory Micrornas In Epithelial-Mesenchymal Transition During Experimental Bleomycin-Induced Lung Fibrosis

M. Yamada, H. Kubo, N. Fujino, M. He, T. Suzuki, T. Takahashi, C. Ota, T. Aoyagi, H. Kunishima, M. Yamaya, M. Kaku

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　2011
ENDOGENOUS STEM CELL POPULATION IN ADULT HUMAN LUNGS

Hiroshi Kubo, Fujino Naoya, Takaya Suzuki, Chiharu Ota, Toru Takahasi, Mei He, Mitsuhiro Yamada, Mutsuo Yamaya

RESPIROLOGY　2010/11

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Research Projects 11

学童期の尿中Na/K比を利用した生活習慣病予測スコアの算出と食行動変容促進の試み

大田千晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2025/06/27 - 2028/03/31
Application of Home Blood Pressure Monitoring in Adolescents and Young Adults: Genetic and Environmental Influences Between Parents and Offspring

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku Medical and Pharmaceutical University

2025/04/01 - 2028/03/31
Do omega-3 fatty acids during pregnancy affect IQ at 10 years old?

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institute for Environmental Studies

2024/04/01 - 2027/03/31
成人先天性心疾患患者の長期予後改善に向けた包括的加齢リスク評価法の確立

建部俊介, 安田聡, 大田千晴, 矢尾板信裕, 竹内雅史, 鈴木秀明, 岩澤伸哉, 舘脇康子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04/01 - 2027/03/31
Examining the effects of omega-3 fatty acids in pregnancy on IQ at age 10

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2023/04/01 - 2027/03/31
胎児期及び乳児期のオメガ３系脂肪酸は８歳のADHD様行動を改善するか

安里要, 川端輝江, 仲井邦彦, 龍田希, 鈴木吉也, 大田千晴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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小児の注意欠如・多動症（ADHD）の症例は増加しており、妊娠から授乳期のオメガ3系多価不飽和脂肪酸（ω3系PUFA）がADHA予防に寄与すると報告されているが、我が国にADHDと脂肪酸栄養に関わるエビデンスは少ない。そこで、本研究では日本人でも胎児から乳児期のω3系PUFAが学童期のADHD様行動に影響するのか、大規模出生コホート調査「子どもの健康と環境に関する全国調査（エコチル調査）」の枠組みを活用し検証する。８歳のADHD様行動を注意集中機能検査により評価し、臍帯血ω3系PUFA、または乳児期のω3系PUFA摂取との関連性を解析し、脂肪酸栄養と小児神経発達に関わる栄養疫学的エビデンスの構築を目指す。臍帯血ω3系PUFA濃度が高い場合に８歳のADHD様行動スコアが低下するか、母乳及び人工乳として摂取したω3系PUFAが多い場合に同じくADHD様行動スコアが低下するかの検証を行う。さらに、授乳の影響ならびに粉ミルク中のω3:ω6比率の効果についても感度分析により検証を行うこととした。対象者は、母体血及び臍帯血の赤血球中多価不飽和脂肪酸分析を行った宮城県沿岸部在住の母児である。本研究2年目である令和４年度においても昨年度に引き続き脂肪酸組成値の再評価を行い、母体血（妊娠中期）および臍帯血中の脂肪酸組成、母乳中脂肪酸組成値および調製粉乳の使用状況の確認を行なった。その他の共変量である家庭環境や母親のIQ、食習慣等の情報は継続して連結および整理を行っている。
Analysis of predictors of attention deficit / hyperactivity disorder by longitudinal analysis

Nakai Kunihiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04/01 - 2023/03/31

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A prospective cohort study was conducted on the onset of developmental disorders such as attention-deficit/hyperactivity disorder and autism spectrum disorder, to examine the associations between behavioral observations by homeroom teachers at nursery schools and kindergartens before entering school and the diagnosis of developmental disorders. It was suggested that the homeroom teacher's behavior observation was related to the diagnosis of developmental disorders. Furthermore, when we examined the relationship between maternal nutritional status of polyunsaturated fatty acids and maternal blood testosterone exposure during pregnancy and developmental disorders, it was suggested that the risk of attention deficit/hyperactivity disorder is high when testosterone levels in maternal blood are high. Considering the incidence of developmental disorders, the number of cases was considered to be still small, and continued observation was considered necessary.
Investigation of the pathophysiology and the treatment for pulmonary fibrosis associated with bronchopulmonary dysplasia

Ota Chiharu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2019/04/01 - 2022/03/31

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The purpose of this study was to clarify the pathogenesis of pulmonary hypertension associated with chronic lung disease in premature infants (BPD-PH). Immunostaining with alveolar epithelial cell markers and vascular endothelial cell markers was performed using BPD-PH patient lungs (transplant donor lungs), and the distribution in BPD-PH patient lungs was investigated. We analyzed the CT findings of a BPD-PH patient who had been treated with pulmonary vasodilators for 10 years, performed volumetry using analysis software, and reported the results in a paper together with the case. Using commercially available isolated alveolar epithelial cells and pulmonary fibroblasts, we seeded them on Matrigel and performed alveolar-like organoid/spheroid formation experiments under the conditions of adding various growth factors.
Investigating the drugs to repair injured alveolar epithelial cells using type 2 alveolar epithelial progenitor cells with ABCA3 mutations

Ota Chiharu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04/01 - 2020/03/31

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Patients with homozygous or compound heterozygous mutations in ABCA3 gene cause severe lung diseases in infants and children. We isolated an alveolar epithelial progenitor cells (AEPCs) from human lungs. In the present study, we isolated AEPCs from 2 patients without ABCA3 mutations and from 2 patients with different ABCA3 mutations and analyzed the differentially expressed genes of the two groups. We evaluated the differentially expressed genes of AT2 derived from ABCA3-wt- and ABCA3-mt-AEPCs. Changes of cell polarity and epithelial barrier function, development associated genes in AT2 with ABCA3 mutation might be involved in the disease development.
HOPXによる肺胞傷害時のWnt/β-catenin signaling制御機構の解明

大田千晴

Offer Organization: グラクソ・スミスクライン株式会社

System: GSK研究助成

2018/10 - 2019/10
Role of cell-specific developmental Wnt signal impairment for chronic lung disease

Chiharu Ota

Offer Organization: European Respiratory Society

System: Long Term Research Fellowship

Category: Medicine

Institution: Comprehensive Pneumology Center, Helmholtz Center Munich, Munich, Germany

2015/10 - 2017/10

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