Details of the Researcher

PHOTO

Hiroaki Baba
Section
Graduate School of Medicine
Job title
Senior Assistant Professor
Degree

  • 博士（医学）（東北大学）

Research Areas 1

  • Life sciences / Infectious disease /

Awards 2

  1. Travel Award of Japanese Society for Infection Prevention and Control 2022

    2022/12　Successful containment of a cluster of invasive candidiasis caused by fluconazole-non-susceptible Candida parapsilosis in a neonatal intensive care unit

  2. 大島賞

    日本臨床腸内微生物学会

Papers 81

  1. Validation of the United States isolation termination criteria using virus culture results of the omicron variant in Japan

    Issei Seike, Hiroaki Baba, Michiko Okamoto, Asami Nakayama, Tetsuji Aoyagi

    Journal of Infection and Chemotherapy　2025/06

    DOI： 10.1016/j.jiac.2025.102714 　

  2. カテーテル関連血流感染を繰り返す在宅中心静脈栄養療法患者への環境調査に基づく再発防止策の検討

    遠藤 春樹, 北村 知穂, 千葉 美紀子, 馬場 啓聡, 鈴木 博也, 金森 肇, 池田 しのぶ, 徳田 浩一

    日本環境感染学会総会プログラム・抄録集　39回　417-417　2024/07

    Publisher: (一社)日本環境感染学会

  3. カテーテル関連血流感染を繰り返す在宅中心静脈栄養療法患者への環境調査に基づく再発防止策の検討

    遠藤 春樹, 北村 知穂, 千葉 美紀子, 馬場 啓聡, 鈴木 博也, 金森 肇, 池田 しのぶ, 徳田 浩一

    日本環境感染学会総会プログラム・抄録集　39回　417-417　2024/07

    Publisher: (一社)日本環境感染学会

  4. こども病院における入院患者及び排水由来の薬剤耐性菌モニタリング

    馬場 啓聡, 金森 肇, 桜井 博毅, 谷河 翠

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　98回・72回　np213-np213　2024/05

    Publisher: 日本感染症学会・日本化学療法学会

  5. 正しい環境消毒法

    馬場 啓聡, 金森 肇

    感染と消毒　31　(1)　30-34　2024/05

    Publisher: サラヤ(株)

    ISSN： 1346-2326

  6. Undiagnosed Perihepatic Abscess Revealed at Autopsy of a Patient With COVID-19 Undergoing Prolonged Extracorporeal Membrane Oxygenation (ECMO) Therapy. International-journal Peer-reviewed

    Issei Seike, Kengo Oshima, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi

    Cureus　16　(4)　e58338　2024/04

    DOI： 10.7759/cureus.58338 　

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    The use of extracorporeal membrane oxygenation (ECMO) increased during the COVID-19 pandemic. However, complications associated with the long-term use of ECMO are poorly understood. This case report describes the autopsy findings of a perihepatic abscess in a patient with long-term COVID-19, which could not be diagnosed before death. In cases where the source of infection remains elusive but uncontrolled infections occur, we recommend the combined use of ultrasonography and contrast-enhanced computed tomography (CT) in patients with COVID-19 undergoing prolonged ECMO support, with particular consideration given to the potential development of cholecystitis.

  7. Salmonella Enteritidisによる人工弁感染性心内膜炎に大動脈弁輪部膿瘍を合併した1例

    北谷 栞, 馬場 啓聡, 徳田 浩一, 金森 肇

    感染症学雑誌　98　(1)　83-84　2024/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  8. A cluster of Candida parapsilosis displaying fluconazole-trailing in a neonatal intensive care unit successfully contained by multiple infection-control interventions Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Asami Nakayama, Takami Sato, Makoto Katsumi, Takae Chida, Shinobu Ikeda, Rio Seki, Teppei Arai, Katsuhiko Kamei, Koichi Tokuda

    Antimicrobial Stewardship & Healthcare Epidemiology　2024

    DOI： 10.1017/ash.2024.77 　

  9. Salmonella Enteritidisによる人工弁感染性心内膜炎に大動脈弁輪部膿瘍を合併した1例 Peer-reviewed

    北谷 栞, 馬場 啓聡, 徳田 浩一, 金森 肇

    感染症学雑誌　98　(1)　83-84　2024/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  10. Salmonella Enteritidis ST11 Prosthetic Valve Endocarditis Complicated by a Paravalvular Abscess: Case Report and Literature Review Peer-reviewed

    Shiori Kitaya, Shintaro Katahira, Hiroaki Baba, Yoshikatsu Saiki, Yukio Katori, Koichi Tokuda, Hajime Kanamori

    Applied Microbiology　3　(3)　1057-1067　2023/09/08

    Publisher: MDPI AG

    DOI： 10.3390/applmicrobiol3030073 　

    eISSN： 2673-8007

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    Salmonella infection typically causes self-limiting gastroenteritis. However, in rare cases, it can lead to prosthetic valve endocarditis (PVE), especially in older adults with a history of valve replacement surgery. In this case study, we describe a case of Salmonella PVE in a man with a prosthetic aortic valve. Complications of PVE include abscess formation, which is associated with increased mortality. If a patient with a history of prosthetic valve replacement presents with symptoms suggestive of gastroenteritis or bacteremia, a thorough investigation should be conducted with suspicion of PVE. The prognosis of Salmonella PVE can be improved by promptly initiating appropriate antibiotics and administering them for an adequate duration, as well as by considering surgical intervention when necessary. Additionally, confirming negative blood cultures after treatment of Salmonella bacteremia is important to prevent the development of PVE and paravalvular abscesses.

  11. サルモネラ人工弁感染性心内膜炎に関するレビュー

    北谷 栞, 片平 晋太郎, 馬場 啓聡, 齋木 佳克, 香取 幸夫, 徳田 浩一, 金森 肇

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　26回　26-26　2023/08

    Publisher: 日本臨床腸内微生物学会

  12. 集中治療室におけるSerratia marcescens菌血症集積事例の検討

    馬場 啓聡, 金森 肇

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　26回　27-27　2023/08

    Publisher: 日本臨床腸内微生物学会

  13. サルモネラ人工弁感染性心内膜炎に関するレビュー

    北谷 栞, 片平 晋太郎, 馬場 啓聡, 齋木 佳克, 香取 幸夫, 徳田 浩一, 金森 肇

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　26回　26-26　2023/08

    Publisher: 日本臨床腸内微生物学会

  14. 集中治療室におけるSerratia marcescens菌血症集積事例の検討

    馬場 啓聡, 金森 肇

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　26回　27-27　2023/08

    Publisher: 日本臨床腸内微生物学会

  15. Screening for Metallo-Beta-Lactamases Using Non-Carbapenem Agents: Effective Detection of MBL-Producing Enterobacterales and Differentiation of Carbapenem-Resistant Enterobacterales. International-journal Peer-reviewed

    Kentarou Takei, Hajime Kanamori, Asami Nakayama, Mikiko Chiba, Yumiko Takei, Issei Seike, Chiho Kitamura, Hiroaki Baba, Kengo Oshima, Koichi Tokuda

    Antibiotics (Basel, Switzerland)　12　(7)　2023/07

    DOI： 10.3390/antibiotics12071146 　

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    Metallo-beta-lactamases (MBLs) are enzymes that break down carbapenem antibiotics, leading to carbapenem-resistant organisms. Carbapenemase-resistant Enterobacterales (CRE) is one of them. Outbreaks of CRE infection can occur in healthcare facilities and lead to increased deaths, illness, and medical costs. This study was conducted to detect MBLs using non-carbapenem agents and exclude MBLs among CRE isolates. A total of 3776 non-duplicate sequential Enterobacterales isolates from a single facility were screened between January 2019 and December 2022 using non-carbapenem agents, ceftazidime and cefoperazone/sulbactam. Positive 153 isolates (4.0%) were further tested using carbapenemase-confirmation tests and verified through polymerase chain reaction (PCR) testing. Fifteen imipenemase (IMP)-type MBL-producing Enterobacterales (0.4%) including one susceptible to carbapenems were identified. Moreover, 160 isolates (4.2%) meeting the criteria for CRE were directly subjected to PCR testing. All fourteen CRE isolates with MBLs identified through PCR testing were found to be the same strains screened using ceftazidime and cefoperazone/sulbactam. Screening using ceftazidime and cefoperazone/sulbactam can effectively detect MBL-producing Enterobacterales strains. This screening method showed comparable results to screening with meropenem, potentially serving as a supplementary approach and contributing to differentiating between MBL- and non-MBL-producing CRE strains. Our findings support these screening methods, particularly in regions where IMP-type MBLs are prevalent.

  16. Highly sensitive detection of antimicrobial resistance genes in hospital wastewater using the multiplex hybrid capture target enrichment. International-journal Peer-reviewed

    Hiroaki Baba, Makoto Kuroda, Tsuyoshi Sekizuka, Hajime Kanamori

    mSphere　e0010023　2023/05/24

    DOI： 10.1128/msphere.00100-23 　

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    Wastewater can be useful in monitoring the spread of antimicrobial resistance (AMR) within a hospital. The abundance of antibiotic resistance genes (ARGs) in hospital effluent was assessed using metagenomic sequencing (mDNA-seq) and hybrid capture (xHYB). mDNA-seq analysis and subsequent xHYB targeted enrichment were conducted on two effluent samples per month from November 2018 to May 2021. Reads per kilobase per million (RPKM) values were calculated for all 1,272 ARGs in the constructed database. The monthly numbers of patients with presumed extended-spectrum β-lactamase (ESBL)-producing and metallo-β-lactamase (MBL)-producing bacteria, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant enterococci (VRE) were compared with the monthly RPKM values of blaCTX-M, blaIMP, mecA, vanA, and vanB by xHYB. The average RPKM value for all ARGs detected by xHYB was significantly higher than that of mDNA-seq (665, 225, and 328, respectively, and P < 0.05). The average number of patients with ESBL producers and RPKM values of blaCTX-M-1 genes in 2020 were significantly higher than that in 2019 (17 and 13 patients per month and 921 vs 232 per month, respectively, both P < 0.05). The average numbers of patients with MBL-producers, MRSA, and VRE were 1, 28, and 0 per month, respectively, while the average RPKM values of blaIMP, mecA, vanA, and vanB were 6,163, 6, 0, and 126 per month, respectively. Monitoring ARGs in hospital effluent using xHYB was found to be more useful than conventional mDNA-seq in detecting ARGs including blaCTX-M, blaIMP, and vanB, which are important for infection control.IMPORTANCEEnvironmental ARGs play a crucial role in the emergence and spread of AMR that constitutes a significant global health threat. One major source of ARGs is effluent from healthcare facilities, where patients are frequently administered antimicrobials. Culture-independent methods, including metagenomics, can detect environmental ARGs carried by non-culturable bacteria and extracellular ARGs. mDNA-seq is one of the most comprehensive methods for environmental ARG surveillance; however, its sensitivity is insufficient for wastewater surveillance. This study demonstrates that xHYB appropriately monitors ARGs in hospital effluent for sensitive identification of nosocomial AMR dissemination. Correlations were observed between the numbers of inpatients with antibiotic-resistant bacteria and the ARG RPKM values in hospital effluent over time. ARG surveillance in hospital effluent using the highly sensitive and specific xHYB method could improve our understanding of the emergence and spread of AMR within a hospital.

  17. Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. International-journal Peer-reviewed

    Yudai Iwasaki, Yusuke Takei, Mitsuhiro Yamada, Shigekazu Sugino, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Kentarou Takei, Koichi Tokuda, Eichi N Kodama, Tetsuro Kamo, Tadashi Kamio, Takehiko Kasai, Satoru Ogawa, Masanori Yamauchi

    Journal of clinical medicine　12　(10)　2023/05/14

    DOI： 10.3390/jcm12103460 　

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    Coronavirus disease 2019 (COVID-19) is associated with coagulopathy. However, the underlying mechanisms are not completely understood. We evaluated the association between COVID-19 coagulopathy and extracellular vesicle (EV) levels. We hypothesized that several EV levels would be higher in COVID-19 coagulopathy patients than in non-coagulopathy patients. This prospective observational study was conducted in four tertiary care faculties in Japan. We enrolled 99 COVID-19 patients (48 with coagulopathy and 51 without coagulopathy) aged ≥20 years who required hospitalization, and 10 healthy volunteers; we divided the patients into coagulopathy and non-coagulopathy groups according to the D-dimer levels (≥1 μg/mL and <1 μg/mL, respectively). We used flow cytometry to measure the tissue-factor-bearing, endothelium-derived, platelet-derived, monocyte-derived, and neutrophil-derived EV levels in platelet-free plasma. The EV levels were compared between the two COVID-19 groups as well as among the coagulopathy patients, non-coagulopathy patients, and healthy volunteers. No significant difference was found in EV levels between the two groups. Meanwhile, the cluster of differentiation (CD) 41 + EV levels were significantly higher in COVID-19 coagulopathy patients than in healthy volunteers (549.90 [255.05-984.65] vs. 184.3 [150.1-254.1] counts/µL, p = 0.011). Therefore, CD41+ EVs might play an essential role in COVID-19 coagulopathy development.

  18. Severe pneumonia due to legionella and SARS-CoV-2 co-infection necessitating medical evacuation from a cargo ship. International-journal Peer-reviewed

    Shiori Kitaya, Hiroaki Baba, Michiko Okamoto, Masahiro Sakamoto, Asami Nakayama, Yumiko Takei, Issei Seike, Kentarou Takei, Kengo Oshima, Koichi Tokuda, Takuya Shiga, Hajime Kanamori

    Journal of travel medicine　30　(5)　2023/05/09

    DOI： 10.1093/jtm/taad067 　

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    Cargo ships are at risk of disease outbreaks like Legionella and SARS-CoV-2 due to their cramped and shared conditions. A case of medical evacuation due to co-infection of Legionella pneumophila with SARS-CoV-2 highlights the need for international infection control guidelines, information networks, and molecular epidemiological approaches for identifying infection routes.

  19. Novel Virus Air Sampler Based on Electrostatic Precipitation and Air Sampling of SARS-CoV-2. International-journal Peer-reviewed

    Kyohei Fukuda, Hiroaki Baba, Mie Yoshida, Kouichi Kitabayashi, Shinjirou Katsushima, Hiroki Sonehara, Kazue Mizuno, Hajime Kanamori, Koichi Tokuda, Atsuhiro Nakagawa, Akira Mizuno

    Microorganisms　11　(4)　2023/04/04

    DOI： 10.3390/microorganisms11040944 　

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    The assessment of airborne viruses in air is a critical step in the design of appropriate prevention and control measures. Hence, herein, we developed a novel wet-type electrostatic air sampler using a viral dissolution buffer containing a radical scavenging agent, and verified the concentration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the air of hospital rooms inhabiting coronavirus disease 2019 (COVID-19) patients and public areas. RNA damage caused by corona discharge was negligible when Buffer AVL was used as the collecting electrode. The viral RNA concentration in the air of the room varied by patient: 3.9 × 103 copy/m3 on the 10th day after onset in a mild case and 1.3 × 103 copy/m3 on the 18th day in a severe case. Viral RNA levels were 7.8 × 102 and 1.9 × 102 copy/m3 in the air of the office and food court, respectively, where people removed their masks when eating and talking, but it remained undetected in the station corridor where all the people were wearing masks. The assessment of airborne SARS-CoV-2 RNA using the proposed sampler can serve as a basis for the safe discontinuation of COVID-19 isolation precautions to identify exposure hotspots and alert individuals at increased infection risks.

  20. Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolated from municipal and hospital wastewater in Japan Peer-reviewed

    Rio Shibuki, Masateru Nishiyama, Masaya Mori, Hiroaki Baba, Hajime Kanamori, Toru Watanabe

    Journal of Global Antimicrobial Resistance　2023/03

    DOI： 10.1016/j.jgar.2023.02.002 　

  21. HSVによる肝炎発症後,産褥期にElsberg症候群を発症した一症例

    北村 知穂, 武井 健太郎, 清家 一生, 馬場 啓聡, 金森 肇, 大島 謙吾, 徳田 浩一

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-181　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  22. 東北大学病院における持続的菌血症の検討

    北谷 栞, 金森 肇, 大島 謙吾, 馬場 啓聡, 武井 健太郎, 清家 一生, 勝見 真琴, 徳田 浩一

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-087　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  23. 新型コロナウイルスとLegionella pneumophilaの共感染による重症肺炎で太平洋上の貨物船から医療搬送された一例

    北谷 栞, 馬場 啓聡, 大島 謙吾, 武井 健太郎, 清家 一生, 徳田 浩一, 中山 麻美, 金森 肇

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-143　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  24. 下水由来のカルバペネマーゼ産生グラム陰性菌のゲノム解析

    馬場 啓聡, 金森 肇, 西山 正晃, 武井 祐美子, 渡部 徹

    日本化学療法学会雑誌　71　(2)　171-171　2023/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  25. 潰瘍性大腸炎治療中にリステリア菌血症を発症した一例

    郷 愛太, 大島 謙吾, 馬場 啓聡, 徳田 浩一, 金森 肇

    日本化学療法学会雑誌　71　(2)　175-175　2023/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  26. Clinical and Epidemiological Characteristics of Persistent Bacteremia: A Decadal Observational Study Peer-reviewed

    Shiori Kitaya, Hajime Kanamori, Hiroaki Baba, Kengo Oshima, Kentarou Takei, Issei Seike, Makoto Katsumi, Yukio Katori, Koichi Tokuda

    Pathogens　12　(2)　212-212　2023/01/29

    Publisher: MDPI AG

    DOI： 10.3390/pathogens12020212 　

    eISSN： 2076-0817

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    Background: Bloodstream infections (BSIs), including persistent bacteremia (PB), are a leading source of morbidity and mortality globally. PB has a higher mortality rate than non- PB, but the clinical aspects of PB in terms of the causative pathogens and the presence of clearance of PB are not well elucidated. Therefore, this study aimed to describe the clinical and epidemiological characteristics of PB in a real-world clinical setting. Methods: We performed a retrospective observational survey of patients who underwent blood culture between January 2012 and December 2021 at Tohoku University Hospital. Cases of PB were divided into three groups depending on the causative pathogen: gram-positive cocci (GPC), gram-negative rods (GNRs), and Candida spp. For each group, we examined the clinical and epidemiological characteristics of PB, including differences in clinical features depending on the clearance of PB. The main outcome variable was mortality, assessed as early (30-day), late (30–90 day), and 90-day mortality. Results: Overall, we identified 31,591 cases of single bacteremia; in 6709 (21.2%) cases, the first blood culture was positive, and in 3124 (46.6%) cases, a follow-up blood culture (FUBC) was performed. Of the cases with FUBCs, 414 (13.2%) were confirmed to be PB. The proportion of PB cases caused by Candida spp. was significantly higher (29.6%, 67/226 episodes) than that for GPC (11.1%, 220/1974 episodes, p &lt; 0.001) and GNRs (12.1%, 100/824 episodes, p &lt; 0.001). The Candida spp. group also had the highest late (30–90 day) and 90-day mortality rates. In all three pathogen groups, the subgroup without the clearance of PB tended to have a higher mortality rate than the subgroup with clearance. Conclusions: Patients with PB due to Candida spp. have a higher late (30–90 day) and 90-day mortality rate than patients with PB due to GPC or GNRs. In patients with PB, FUBCs and confirming the clearance of PB are useful to improve the survival rate.

  27. Statistical Analysis of Mortality Rates of Coronavirus Disease 2019 (COVID-19) Patients in Japan Across the 4C Mortality Score Risk Groups, Age Groups, and Epidemiological Waves: A Report From the Nationwide COVID-19 Cohort. International-journal Peer-reviewed

    Hiroaki Baba, Saori Ikumi, Shotaro Aoyama, Tetsuo Ishikawa, Yusuke Asai, Nobuaki Matsunaga, Norio Ohmagari, Hajime Kanamori, Koichi Tokuda, Takuya Ueda, Eiryo Kawakami

    Open forum infectious diseases　10　(1)　ofac638　2023/01

    DOI： 10.1093/ofid/ofac638 　

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    BACKGROUND: The mortality rates of coronavirus disease 2019 (COVID-19) have been changed across the epidemiological waves. The aim was to investigate the differences in mortality rates of COVID-19 patients in Japan across the 6 epidemiological waves stratified by age group and Coronavirus Clinical Characterisation Consortium (4C) mortality score risk group. METHODS: A total of 56 986 COVID-19 patients in the COVID-19 Registry Japan from 2 March 2020 to 1 February 2022 were enrolled. These patients were categorized into 4 risk groups based on their 4C mortality score. Mortality rates of each risk group were calculated separately for different age groups: 18-64, 65-74, 75-89, and ≥90 years. In addition, mortality rates across the wave periods were calculated separately in 2 age groups: <75 and ≥75 years. All calculated mortality rates were compared with reported data from the United Kingdom (UK) during the early epidemic. RESULTS: The mortality rates of patients in Japan were significantly lower than in the UK across the board, with the exception of patients aged ≥90 years at very high risk. The mortality rates of patients aged ≥75 years at very high risk in the fourth and fifth wave periods showed no significant differences from those in the UK, whereas those in the sixth wave period were significantly lower in all age groups and in all risk groups. CONCLUSIONS: The present analysis showed that COVID-19 patients had a lower mortality rate in the most recent sixth wave period, even among patients ≥75 years old at very high risk.

  28. 新型コロナウイルスの感染性リスク評価における検討

    中山 麻美, 岡本 道子, 馬場 啓聡, 金森 肇, 千葉 美紀子, 三浦 悠理子, 勝見 真琴, 阿部 裕子, 藤巻 慎一

    日本臨床微生物学会雑誌　33　(Suppl.1)　244-244　2022/12

    Publisher: (一社)日本臨床微生物学会

    ISSN： 2434-866X

  29. 新型コロナウイルスの感染性リスク評価における検討

    中山 麻美, 岡本 道子, 馬場 啓聡, 金森 肇, 千葉 美紀子, 三浦 悠理子, 勝見 真琴, 阿部 裕子, 藤巻 慎一

    日本臨床微生物学会雑誌　33　(Suppl.1)　244-244　2022/12

    Publisher: (一社)日本臨床微生物学会

    ISSN： 2434-866X

  30. Emphysematous gastritis due to hypervirulent Klebsiella pneumoniae. International-journal

    Naomi Saeki, Kentaro Takei, Ken Katsuta, Akihiko Nakasato, Hiroaki Baba, Kengo Oshima, Koichi Tokuda, Shigeki Kushimoto, Hajime Kanamori

    The Lancet. Infectious diseases　22　(11)　1648-1648　2022/11

    DOI： 10.1016/S1473-3099(22)00545-X 　

  31. Severe coronavirus disease 2019 in a patient with TAFRO syndrome: A case report. International-journal

    Kengo Oshima, Hajime Kanamori, Kentarou Takei, Hiroaki Baba, Koichi Tokuda

    Clinical infection in practice　16　100158-100158　2022/11

    DOI： 10.1016/j.clinpr.2022.100158 　

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    Background: TAFRO syndrome, a subtype of idiopathic multicentric Castleman disease, is an acute or subacute systemic inflammatory disease that causes fever, generalized oedema (pleural effusion or ascites), and thrombocytopenia and is associated with renal impairment, anaemia, and organomegaly (hepatosplenomegaly and lymph node enlargement). Coronavirus disease 2019 (COVID-19)-associated hyperinflammation is caused by dysregulation of proinflammatory cytokines. Cytokine storm syndrome is common to both COVID-19 and TAFRO syndrome.Case report.A 66-year-old man with TAFRO syndrome was admitted because of worsening renal function, right pleural effusion, and ascites. He was taking 20 mg prednisolone orally and 25 mg cyclosporin A orally twice daily. Despite administration of maximum oxygenation and remdesivir, the patient developed acute respiratory distress syndrome (ARDS) and was transferred to the intensive care unit. Results: Chest radiography showed bilateral lung infiltration. COVID-19 was confirmed with a positive polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2. Chest and abdominal computed tomography showed massive ground-glass opacities in both lungs, slight right pleural effusion, hepatomegaly, splenomegaly, and ascites. Conclusion: To the best of our knowledge, this is the first report of COVID-19 in a patient with TAFRO syndrome. Despite receiving a moderate dose of a corticosteroid and a monoclonal antibody against the IL-6 receptor, our patient developed severe pneumonia, suggesting that strong immunomodulatory therapy in the antiviral phase of COVID-19 may promote viral growth and induce ARDS.

  32. Clinical features of COVID-19 patients with rebound phenomenon after corticosteroid therapy

    Koji Murakami, Hirohito Sano, Naoki Tode, Yoko Tsukita, Kei Sato, Daisuke Narita, Nozomu Kimura, Shuichiro Matsumoto, Yoshinao Ono, Chikashi Iwasaki, Hatsumi Sugiyama, Manami Suzuki, Sho Kakuto, Shuichi Konno, Hajime Kanamori, Hiroaki Baba, Kengo Oshima, Kentarou Takei, Koichi Tokuda, Tsutomu Tamada, Hisatoshi Sugiura

    BMJ OPEN RESPIRATORY RESEARCH　9　(1)　2022/09

    DOI： 10.1136/bmjresp-2022-001332 　

    eISSN： 2052-4439

  33. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. International-journal

    Qingbo S Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-O, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada

    Nature communications　13　(1)　4830-4830　2022/08/22

    DOI： 10.1038/s41467-022-32276-2 　

    More details Close

    Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.

  34. DOCK2 is involved in the host genetics and biology of severe COVID-19. International-journal

    Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu-Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Toshihiro Kishikawa, Shuhei Yamada, Shuhei Kawabata, Noriyuki Kijima, Masatoshi Takagaki, Noah Sasa, Yuya Ueno, Motoyuki Suzuki, Norihiko Takemoto, Hirotaka Eguchi, Takahito Fukusumi, Takao Imai, Munehisa Fukushima, Haruhiko Kishima, Hidenori Inohara, Kazunori Tomono, Kazuto Kato, Meiko Takahashi, Fumihiko Matsuda, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, Kazuyoshi Watanabe, Naoki Miyazawa, Yasuhiro Kimura, Reiko Sado, Hideyasu Sugimoto, Akane Kamiya, Naota Kuwahara, Akiko Fujiwara, Tomohiro Matsunaga, Yoko Sato, Takenori Okada, Yoshihiro Hirai, Hidetoshi Kawashima, Atsuya Narita, Kazuki Niwa, Yoshiyuki Sekikawa, Koichi Nishi, Masaru Nishitsuji, Mayuko Tani, Junya Suzuki, Hiroki Nakatsumi, Takashi Ogura, Hideya Kitamura, Eri Hagiwara, Kota Murohashi, Hiroko Okabayashi, Takao Mochimaru, Shigenari Nukaga, Ryosuke Satomi, Yoshitaka Oyamada, Nobuaki Mori, Tomoya Baba, Yasutaka Fukui, Mitsuru Odate, Shuko Mashimo, Yasushi Makino, Kazuma Yagi, Mizuha Hashiguchi, Junko Kagyo, Tetsuya Shiomi, Satoshi Fuke, Hiroshi Saito, Tomoya Tsuchida, Shigeki Fujitani, Mumon Takita, Daiki Morikawa, Toru Yoshida, Takehiro Izumo, Minoru Inomata, Naoyuki Kuse, Nobuyasu Awano, Mari Tone, Akihiro Ito, Yoshihiko Nakamura, Kota Hoshino, Junichi Maruyama, Hiroyasu Ishikura, Tohru Takata, Toshio Odani, Masaru Amishima, Takeshi Hattori, Yasuo Shichinohe, Takashi Kagaya, Toshiyuki Kita, Kazuhide Ohta, Satoru Sakagami, Kiyoshi Koshida, Kentaro Hayashi, Tetsuo Shimizu, Yutaka Kozu, Hisato Hiranuma, Yasuhiro Gon, Namiki Izumi, Kaoru Nagata, Ken Ueda, Reiko Taki, Satoko Hanada, Kodai Kawamura, Kazuya Ichikado, Kenta Nishiyama, Hiroyuki Muranaka, Kazunori Nakamura, Naozumi Hashimoto, Keiko Wakahara, Sakamoto Koji, Norihito Omote, Akira Ando, Nobuhiro Kodama, Yasunari Kaneyama, Shunsuke Maeda, Takashige Kuraki, Takemasa Matsumoto, Koutaro Yokote, Taka-Aki Nakada, Ryuzo Abe, Taku Oshima, Tadanaga Shimada, Masahiro Harada, Takeshi Takahashi, Hiroshi Ono, Toshihiro Sakurai, Takayuki Shibusawa, Yoshifumi Kimizuka, Akihiko Kawana, Tomoya Sano, Chie Watanabe, Ryohei Suematsu, Hisako Sageshima, Ayumi Yoshifuji, Kazuto Ito, Saeko Takahashi, Kota Ishioka, Morio Nakamura, Makoto Masuda, Aya Wakabayashi, Hiroki Watanabe, Suguru Ueda, Masanori Nishikawa, Yusuke Chihara, Mayumi Takeuchi, Keisuke Onoi, Jun Shinozuka, Atsushi Sueyoshi, Yoji Nagasaki, Masaki Okamoto, Sayoko Ishihara, Masatoshi Shimo, Yoshihisa Tokunaga, Yu Kusaka, Takehiko Ohba, Susumu Isogai, Aki Ogawa, Takuya Inoue, Satoru Fukuyama, Yoshihiro Eriguchi, Akiko Yonekawa, Keiko Kan-O, Koichiro Matsumoto, Kensuke Kanaoka, Shoichi Ihara, Kiyoshi Komuta, Yoshiaki Inoue, Shigeru Chiba, Kunihiro Yamagata, Yuji Hiramatsu, Hirayasu Kai, Koichiro Asano, Tsuyoshi Oguma, Yoko Ito, Satoru Hashimoto, Masaki Yamasaki, Yu Kasamatsu, Yuko Komase, Naoya Hida, Takahiro Tsuburai, Baku Oyama, Minoru Takada, Hidenori Kanda, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Shozo Yoshida, Shinji Ogura, Shinji Abe, Yuta Kono, Yuki Togashi, Hiroyuki Takoi, Ryota Kikuchi, Shinichi Ogawa, Tomouki Ogata, Shoichiro Ishihara, Arihiko Kanehiro, Shinji Ozaki, Yasuko Fuchimoto, Sae Wada, Nobukazu Fujimoto, Kei Nishiyama, Mariko Terashima, Satoru Beppu, Kosuke Yoshida, Osamu Narumoto, Hideaki Nagai, Nobuharu Ooshima, Mitsuru Motegi, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Mayu Endo, Yoshiyuki Ohira, Masafumi Watanabe, Sumito Inoue, Akira Igarashi, Masamichi Sato, Hironori Sagara, Akihiko Tanaka, Shin Ohta, Tomoyuki Kimura, Yoko Shibata, Yoshinori Tanino, Takefumi Nikaido, Hiroyuki Minemura, Yuki Sato, Yuichiro Yamada, Takuya Hashino, Masato Shinoki, Hajime Iwagoe, Hiroshi Takahashi, Kazuhiko Fujii, Hiroto Kishi, Masayuki Kanai, Tomonori Imamura, Tatsuya Yamashita, Masakiyo Yatomi, Toshitaka Maeno, Shinichi Hayashi, Mai Takahashi, Mizuki Kuramochi, Isamu Kamimaki, Yoshiteru Tominaga, Tomoo Ishii, Mitsuyoshi Utsugi, Akihiro Ono, Toru Tanaka, Takeru Kashiwada, Kazue Fujita, Yoshinobu Saito, Masahiro Seike, Hiroko Watanabe, Hiroto Matsuse, Norio Kodaka, Chihiro Nakano, Takeshi Oshio, Takatomo Hirouchi, Shohei Makino, Moritoki Egi, Yosuke Omae, Yasuhito Nannya, Takafumi Ueno, Kazuhiko Katayama, Masumi Ai, Yoshinori Fukui, Atsushi Kumanogoh, Toshiro Sato, Naoki Hasegawa, Katsushi Tokunaga, Makoto Ishii, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada

    Nature　609　(7928)　754-760　2022/08/08

    DOI： 10.1038/s41586-022-05163-5 　

    More details Close

    Identifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1-5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant on 5q35 (rs60200309-A) near DOCK2 associated with severe COVID-19 in younger (<65 ages) patients (nCase=440, odds ratio=2.01, P=1.2×10-8). This risk allele was prevalent in East Asians but rare in Europeans, showing a value of non-European GWAS. RNA-seq of 473 bulk peripheral blood identified decreasing effect of the risk allele on DOCK2 expression in younger patients. DOCK2 expression was suppressed in severe forms of COVID-19. Single cell RNA-seq analysis (n=61) identified cell type-specific downregulation of DOCK2 and COVID-19-specific decreasing effects of the risk allele on DOCK2 in non-classical monocytes. Immunohistochemistry of lung specimens from severe COVID-19 pneumonia showed suppressed DOCK2. Moreover, inhibition of DOCK2 function using CPYPP induced much more severe pneumonia in a Syrian hamster model of SARS-CoV-2 infection characterized as weight loss, lung edema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 plays an important role in the host immune response to SARS-CoV-2 infection and development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target.

  35. Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan. International-journal

    Kengo Oshima, Chie Nakajima, Kazushige Hirata, Hironori Hayashi, Eiichi N Kodama, Yukari Fukushima, Yasuhiko Suzuki, Hajime Kanamori, Hiroaki Baba, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　28　(7)　965-970　2022/07

    DOI： 10.1016/j.jiac.2022.02.008 　

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    Tuberculosis remains a major public health concern. Millions of tuberculosis cases and associated deaths have been reported worldwide. The Indo-Oceanic lineage Mycobacterium tuberculosis is common in Southeast Asia and causes extrapulmonary lesions. Only a few case studies on this lineage with genetic analysis using whole-genome sequencing have been reported in the literature. We present a case of disseminated tuberculosis, characterized by a variety of extrapulmonary lesions and paradoxical reactions, caused by the Indo-Oceanic lineage M. tuberculosis in a woman in Myanmar. A 22-year-old Burmese woman had arthritis in the right knee, with unknown aetiology, and was referred to our hospital. Computed tomography of the trunk revealed multiple nodular shadows in both lungs; swollen mediastinal lymph nodes; and small, low-density areas in the spleen. M. tuberculosis was detected in the sputum sample, joint aspirate, subcutaneous tumor, and exudate. She experienced a variety of paradoxical reactions together with aggressive tuberculosis dissemination in all areas of the body. Whole-genome sequencing of the DNA of MTB obtained from sputum and the right cervical subcutaneous abscess confirmed the Indo-Oceanic lineage of M. tuberculosis, the predominant strain in Myanmar. The Indo-Oceanic lineage M. tuberculosis causes disseminated tuberculosis all over the body including the periungual region. When patients show unusual symptoms, physicians should consider the introduction of new strains from foreign countries. Genetic analyses of the strains are recommended to define and confirm the lineages.

  36. Review of Antimicrobial Resistance in Wastewater in Japan: Current Challenges and Future Perspectives. International-journal Peer-reviewed

    Hiroaki Baba, Masateru Nishiyama, Toru Watanabe, Hajime Kanamori

    Antibiotics (Basel, Switzerland)　11　(7)　2022/06/24

    DOI： 10.3390/antibiotics11070849 　

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    Antimicrobial resistance (AMR) circulates through humans, animals, and the environments, requiring a One Health approach. Recently, urban sewage has increasingly been suggested as a hotspot for AMR even in high-income countries (HICs), where the water sanitation and hygiene infrastructure are well-developed. To understand the current status of AMR in wastewater in a HIC, we reviewed the epidemiological studies on AMR in the sewage environment in Japan from the published literature. Our review showed that a wide variety of clinically important antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), and antimicrobial residues are present in human wastewater in Japan. Their concentrations are lower than in low- and middle-income countries (LMICs) and are further reduced by sewage treatment plants (STPs) before discharge. Nevertheless, the remaining ARB and ARGs could be an important source of AMR contamination in river water. Furthermore, hospital effluence may be an important reservoir of clinically important ARB. The high concentration of antimicrobial agents commonly prescribed in Japan may contribute to the selection and dissemination of AMR within wastewater. Our review shows the importance of both monitoring for AMR and antimicrobials in human wastewater and efforts to reduce their contamination load in wastewater.

  37. COVID-19に対するステロイド治療後再燃例の検討

    村上 康司, 佐野 寛仁, 東出 直樹, 佐藤 慶, 徳田 浩一, 大島 謙吾, 金森 肇, 馬場 啓聡, 武井 健太郎, 玉田 勉, 杉浦 久敏

    日本呼吸器学会誌　11　(増刊)　212-212　2022/04

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  38. COVID-19に対するステロイド治療後再燃例の検討

    村上 康司, 佐野 寛仁, 東出 直樹, 佐藤 慶, 徳田 浩一, 大島 謙吾, 金森 肇, 馬場 啓聡, 武井 健太郎, 玉田 勉, 杉浦 久敏

    日本呼吸器学会誌　11　(増刊)　212-212　2022/04

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  39. Multiple Secondary Healthcare-Associated Infections Due to Carbapenem-Resistant Organisms in a Critically Ill COVID-19 Patient on Extensively Prolonged Venovenous Extracorporeal Membrane Oxygenation Support-A Case Report. International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Kengo Oshima, Yudai Iwasaki, Yuko Ogata, Hirona Nishimaki, Daisuke Konno, Takuya Shiga, Koji Saito, Koichi Tokuda, Tetsuji Aoyagi

    Microorganisms　10　(1)　2021/12/23

    DOI： 10.3390/microorganisms10010019 　

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    Patients with severe Coronavirus disease 2019 (COVID-19) are at high risk for secondary infection with multidrug-resistant organisms (MDROs). Secondary infections contribute to a more severe clinical course and longer intensive care unit (ICU) stays in patients with COVID-19. A man in his 60s was admitted to the ICU at a university hospital for severe COVID-19 pneumonia requiring mechanical ventilation. His respiratory condition worsened further due to persistent bacteremia caused by imipenem-non-susceptible Klebsiella aerogenes and he required VV-ECMO. Subsequently, he developed a catheter-related bloodstream infection (CRBSI) due to Candida albicans, ventilator-associated pneumonia (VAP) due to multidrug-resistant Pseudomonas aeruginosa (MDRP), and a perianal abscess due to carbapenem-resistant K. aerogenes despite infection control procedures that maximized contact precautions and the absence of MDRO contamination in the patient's room environment. He was decannulated from VV-ECMO after a total of 72 days of ECMO support, and was eventually weaned off ventilator support and discharged from the ICU on day 138. This case highlights the challenges of preventing, diagnosing, and treating multidrug-resistant organisms and healthcare-associated infections (HAIs) in the critical care management of severe COVID-19. In addition to the stringent implementation of infection prevention measures, a high index of suspicion and a careful evaluation of HAIs are required in such patients.

  40. Azithromycin: A promising treatment option for Mycobacterium avium complex pulmonary disease in case of intolerance to clarithromycin. International-journal

    Kengo Oshima, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

    Journal of clinical tuberculosis and other mycobacterial diseases　25　100274-100274　2021/12

    DOI： 10.1016/j.jctube.2021.100274 　

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    Macrolide-based combination chemotherapy is recommended for the treatment of Mycobacterium avium complex (MAC) pulmonary disease (MPD). The susceptibility of the MAC to macrolide antibiotics (MAs) determines the efficacy of treatment and clinical course of MPD. However, MAs cause several adverse effects, resulting in the discontinuation of macrolide-based combination chemotherapy. We encountered two women aged 65 years and 66 years diagnosed with MPD based on bronchoscopic examinations. They were initially treated with clarithromycin-based combination chemotherapy. However, neither patient could continue with chemotherapy owing to adverse events such as rash and edema. We switched clarithromycin with azithromycin, and the patients were able to continue chemotherapy without adverse events. Both patients completed their treatment successfully. Azithromycin, which also belongs to the class of MAs, can be a promising therapeutic option for MPD in case of clarithromycin intolerance.

  41. Case Report: Successful Treatment of Five Critically Ill Coronavirus Disease 2019 Patients Using Combination Therapy With Etoposide and Corticosteroids International-journal

    Tetsuji Aoyagi, Yukio Sato, Hiroaki Baba, Takuya Shiga, Issei Seike, Ikumi Niitsuma Sugaya, Kentarou Takei, Yudai Iwasaki, Kengo Oshima, Hajime Kanamori, Makiko Yoshida, Koji Saito, Koichi Tokuda, Mitsuo Kaku

    Frontiers in Medicine　8　718641-718641　2021/09/23

    Publisher: Frontiers Media SA

    DOI： 10.3389/fmed.2021.718641 　

    eISSN： 2296-858X

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    Acute respiratory distress syndrome (ARDS) is the leading cause of mortality in hospitalized patients with coronavirus disease 2019 (COVID-19) because of limited effective therapies. During infection, the accumulation and activation of macrophages and monocytes in the lungs induce inflammatory mediators and contribute to tissue injury, leading to ARDS. However, therapeutic strategies that directly target activated macrophage and monocytes have not been reported. Combination treatment with etoposide (a cytotoxic agent) and a corticosteroid has been widely used for treating hemophagocytic lymphohistiocytosis characterized by the systemic activation of macrophages with overwhelming inflammation. Herein, we present five cases of COVID-19-associated ARDS treated with etoposide and corticosteroids. Three of the five patients were over 65 years of age and had various underlying diseases, including multiple myeloma. Four patients required invasive mechanical ventilation (MV), and one patient refused to be placed on MV due to underlying diseases. All patients were pre-treated with antiviral and/or other anti-inflammatory agents, but their condition deteriorated and hyperinflammation was noted. All five patients responded well to treatment and had an immediate response, as reflected by improvement in their respiratory condition and inflammatory marker levels and rapid resolution of fever after etoposide administration; however, some patients required a second dose of etoposide and longer course of steroids. All patients recovered, and there were no severe adverse events related to the drugs. Following successful treatment in these five patients, we plan to conduct a clinical trial to evaluate the efficacy and safety of combination therapy with etoposide and corticosteroid for treating COVID-19 patients in Japan.

  42. 宮城県における侵襲性リステリア症の分子疫学的検討

    馬場 啓聡, 金森 肇, 角田 梨紗子, 桜井 博毅, 大島 謙吾, 青柳 哲史, 賀来 満夫

    日本臨床腸内微生物学会誌　23　(1)　61-66　2021/06

    Publisher: 日本臨床腸内微生物学会

  43. Disseminated gonococcal infection in a patient with paroxysmal nocturnal haemoglobinuria receiving eculizumab. International-journal

    Ikumi Niitsuma-Sugaya, Hajime Kanamori, Satoshi Ichikawa, Noriko Fukuhara, Issei Seike, Kentaro Takei, Hiroaki Baba, Kengo Oshima, Tetsuji Aoyagi, Hideo Harigae, Koichi Tokuda

    The Lancet. Infectious diseases　21　(5)　741-741　2021/05

    DOI： 10.1016/S1473-3099(20)30930-0 　

  44. Prevalence of Antibiotic-Resistant Bacteria ESKAPE among Healthy People Estimated by Monitoring of Municipal Wastewater. International-journal

    Masateru Nishiyama, Susan Praise, Keiichi Tsurumaki, Hiroaki Baba, Hajime Kanamori, Toru Watanabe

    Antibiotics (Basel, Switzerland)　10　(5)　2021/04/26

    DOI： 10.3390/antibiotics10050495 　

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    There is increasing attention toward factors that potentially contribute to antibiotic resistance (AR), as well as an interest in exploring the emergence and occurrence of antibiotic resistance bacteria (ARB). We monitored six ARBs that cause hospital outbreaks in wastewater influent to highlight the presence of these ARBs in the general population. We analyzed wastewater samples from a municipal wastewater treatment plant (MWWTP) and hospital wastewater (HW) for six species of ARB: Carbapenem-resistant Enterobacteria (CARBA), extended-spectrum β-lactamase producing Enterobacteria (ESBL), multidrug-resistant Acinetobacter (MDRA), multidrug-resistant Pseudomonas aeruginosa (MDRP), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE). We registered a high percentage of ARBs in MWWTP samples (>66%) for all ARBs except for MDRP, indicating a high prevalence in the population. Percentages in HW samples were low (<78%), and no VRE was detected throughout the study. CARBA and ESBL were detected in all wastewater samples, whereas MDRA and MRSA had a high abundance. This result demonstrated the functionality of using raw wastewater at MWWTP to monitor the presence and extent of ARB in healthy populations. This kind of surveillance will contribute to strengthening the efforts toward reducing ARBs through the detection of ARBs to which the general population is exposed.

  45. 担癌患者および自己免疫疾患患者における緑膿菌による前立腺膿瘍の2例

    清家 一生, 金森 肇, 武井 健太郎, 新妻 郁未, 馬場 啓聡, 大島 謙吾, 徳田 浩一, 青柳 哲史

    感染症学雑誌　95　(臨増)　217-217　2021/04

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  46. Rhodotorula mucilaginosaによるカテーテル関連血流感染症の1例

    佐藤 裕真, 金森 肇, 清家 一生, 新妻 郁未, 武井 健太郎, 馬場 啓聡, 大島 謙吾, 徳田 浩一, 青柳 哲史

    感染症学雑誌　95　(臨増)　218-218　2021/04

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  47. Good症候群に伴うサイトメガロウイルス網膜炎の一例

    武井 健太郎, 金森 肇, 清家 一生, 新妻 郁未, 馬場 啓聡, 大島 謙吾, 徳田 浩一, 青柳 哲史

    感染症学雑誌　95　(臨増)　225-225　2021/04

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  48. 発熱と皮疹を主訴としたCOVID-19の2例

    清家 一生, 金森 肇, 馬場 啓聡, 新妻 郁未, 武井 健太郎, 大島 謙吾, 徳田 浩一, 青柳 哲史

    感染症学雑誌　95　(臨増)　259-259　2021/04

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  49. エクリズマブ投与患者における播種性淋菌感染症の1例

    新妻 郁未, 金森 肇, 清家 一生, 武井 健太郎, 馬場 啓聡, 大島 謙吾, 青柳 哲史, 徳田 浩一

    感染症学雑誌　95　(臨増)　289-289　2021/04

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  50. A case of meningitis due to extensively drug-resistant Pseudomonas aeruginosa imported through medical evacuation: Genomic and environmental investigation. International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Makoto Katsumi, Takami Sato, Takae Chida, Shinobu Ikeda, Yuki Suzuki, Hisakazu Yano, Koichi Tokuda

    Journal of travel medicine　28　(6)　2021/03/24

    DOI： 10.1093/jtm/taab047 　

  51. Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan. International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Risako Kakuta, Hiroki Sakurai, Kengo Oshima, Tetsuji Aoyagi, Mitsuo Kaku

    Diagnostic microbiology and infectious disease　99　(3)　115233-115233　2021/03

    DOI： 10.1016/j.diagmicrobio.2020.115233 　

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    We reviewed 18 listeriosis cases in Japan and performed molecular analysis of causative Listeria monocytogenes (LM) isolates. Strains genetically related to those from other countries caused various types of listeriosis, including vascular listeriosis in immunocompetent elderly people. Our results highlight the importance of integrated clinical and genomic analysis of LM.

  52. MOLECULAR CHARACTERIZATION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GENES OF ENTEROBACTERIACEAE ISOLATED FROM MUNCIPAL AND HOSPITAL WASTEWATERS Peer-reviewed

    MORI Masaya, NISHIYAMA Masateru, SHIBUKI Rio, BABA Hiroaki, KANAMORI Hajime, WATANABE Toru

    Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)　77　(7)　III_199-III_207　2021

    Publisher: Japan Society of Civil Engineers

    DOI： 10.2208/jscejer.77.7_iii_199 　

    eISSN： 2185-6648

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    Extended spectrum β-lactamase (ESBL)-producing Enterobacteria (ESBL-Ent), which are resistant to a wide range of antibiotics in beta-lactam group, have been recognized worldwide as a threat causing nosocomial infections. To characterize the ESBL-Ent carried by healthy people, we isolated the bacteria from municipal wastewater (MW) and detected genes (bla) cording β-lactamase production. The same analysis was applied to hospital wastewater (HW) for comparison. Wastewater samples were taken from a municipal wastewater treatment plant and a general hospital twice a month throughout a year from February 2019 in Sendai, Miyagi prefecture, Japan. By incubating on CHROMOagar ESBL, 594 and 102 isolates of ESBL-Ent were obtained from MW and HW, respectively. The species identification of each isolate with detection of specific gene (for Escherichia coli) and sequencing of 16S rRNA (for Enterobacteria) found ten bacterial genera including mainly E. coli, Aeromonas, and Klebsiella. Among 20 types tested, 16 types of bla were detected from these isolates. The classification of detected bla demonstrated that Class A was predominant and, in this class, blaCTX-M group-9 had the highest prevalence in both wastewaters (MW: 51.9%, HW: 35.6%). ESBL-Ent possessing Class A and Class B genes simultaneously, which can degrade peniciline and carbapenem groups of antibiotics, were detected in both MW (1 isolate) and HW (2 isolates). Two important resistance genes blaKPC and blaOXA-1, called overseas carbapenemase in Japan, were also detected from MW and HW isolates. These results indicated that ESBL-Ent, a fraction of which potentially cause infectious diseases difficult to be treated, have been already spread among healthy people living outside hospitals.

  53. Pulmonary infection caused by Mycobacterium marinum in a patient with anorexia nervosa. International-journal

    Kengo Oshima, Yukari Niinuma, Hajime Saito, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

    ERJ open research　7　(1)　2021/01

    DOI： 10.1183/23120541.00782-2020 　

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    Mycobacterium marinum can cause pulmonary infection and can grow at ≤32°C. Physicians should consider M. marinum when examining patients with pulmonary infection and low body temperature or anorexia nervosa, and grow the specimen at ≤32°C. https://bit.ly/3jkzBeq.

  54. 多剤耐性アシネトバクターの病室内環境調査と院内伝播防止に関する検討

    馬場 啓聡, 金森 肇, 佐藤 貴美, 菊地原 紀裕, 徳田 浩一

    日本臨床微生物学会雑誌　31　(Suppl.1)　203-203　2020/12

    Publisher: (一社)日本臨床微生物学会

    ISSN： 2434-866X

  55. 多剤耐性アシネトバクターの病室内環境調査と院内伝播防止に関する検討

    馬場 啓聡, 金森 肇, 佐藤 貴美, 菊地原 紀裕, 徳田 浩一

    日本臨床微生物学会雑誌　31　(Suppl.1)　203-203　2020/12

    Publisher: (一社)日本臨床微生物学会

    ISSN： 2434-866X

  56. Screening of COVID-19-associated hypercoagulopathy using rotational thromboelastometry. International-journal Peer-reviewed

    Yudai Iwasaki, Takuya Shiga, Daisuke Konno, Koji Saito, Tetsuji Aoyagi, Kengo Oshima, Hajime Kanamori, Hiroaki Baba, Koichi Tokuda, Masanori Yamauchi

    Journal of clinical anesthesia　67　109976-109976　2020/12

    DOI： 10.1016/j.jclinane.2020.109976 　

  57. Rethinking One Health approach in the challenging era of COVID-19 pandemic and natural disasters. International-journal

    Hajime Kanamori, Hiroaki Baba, David J Weber

    Infection ecology & epidemiology　11　(1)　1852681-1852681　2020/11/23

    DOI： 10.1080/20008686.2020.1852681 　

  58. Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide. International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Kengo Oshima, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Yukio Sato, Koichi Tokuda, Tetsuji Aoyagi

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　26　(10)　1100-1103　2020/10

    DOI： 10.1016/j.jiac.2020.06.022 　

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    We report a coronavirus disease 2019 (COVID-19) case with rheumatoid arthritis taking iguratimod. The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. The effects of disease-modifying antirheumatic drugs (DMARDs) and ciclesonide on clinical course and viral shedding remain unknown and warrant further investigation.

  59. 宮城県における侵襲性リステリア症の分子疫学的検討

    馬場 啓聡, 金森 肇, 角田 梨紗子, 桜井 博毅, 大島 謙吾, 青柳 哲史, 賀来 満夫

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　23回　32-32　2020/09

    Publisher: 日本臨床腸内微生物学会

  60. 宮城県における侵襲性リステリア症の分子疫学的検討

    馬場 啓聡, 金森 肇, 角田 梨紗子, 桜井 博毅, 大島 謙吾, 青柳 哲史, 賀来 満夫

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　23回　32-32　2020/09

    Publisher: 日本臨床腸内微生物学会

  61. Chromobacterium haemolyticum Pneumonia Associated with Near-Drowning and River Water, Japan. International-journal Peer-reviewed

    Hajime Kanamori, Tetsuji Aoyagi, Makoto Kuroda, Tsuyoshi Sekizuka, Makoto Katsumi, Kenichiro Ishikawa, Tatsuhiko Hosaka, Hiroaki Baba, Kengo Oshima, Koichi Tokuda, Masatsugu Hasegawa, Yu Kawazoe, Shigeki Kushimoto, Mitsuo Kaku

    Emerging infectious diseases　26　(9)　2186-2189　2020/09

    DOI： 10.3201/eid2609.190670 　

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    We report a severe case of Chromobacterium haemolyticum pneumonia associated with near-drowning and detail the investigation of the pathogen and river water. Our genomic and environmental investigation demonstrated that river water in a temperate region can be a source of C. haemolyticum causing human infections.

  62. Are Reservoirs and Transmission Routes the Same or Different Between O157 and Non-O157 Shiga Toxin-Producing Escherichia coli? International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America　71　(5)　1352-1353　2020/08/22

    DOI： 10.1093/cid/ciz1111 　

    ISSN： 1058-4838

  63. 心臓血管外科術後のClostridioides difficile感染症の罹患率、患者背景、治療、及び予後についての検討

    寺山 敬介, 本田 芳宏, 馬場 啓聡, 金森 肇, 國島 広之

    感染症学雑誌　94　(2)　257-257　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  64. 東南アジアで獲得したメタロβ-ラクタマーゼ産生多剤耐性緑膿菌による髄膜炎の1例

    馬場 啓聡, 金森 肇, 鈴木 由希, 中野 竜一, 大江 千紘, 大島 謙吾, 青柳 哲史, 徳田 浩一, 矢野 寿一, 賀来 満夫

    感染症学雑誌　94　(2)　255-255　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  65. 敗血症における細胞外小胞体に包埋されるIL-36サイトカインの基礎的検討

    青柳 哲史, 馬場 啓聡, 金森 肇, 大島 謙吾, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    感染症学雑誌　94　(2)　272-273　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  66. グラム陰性桿菌血液培養陽性例における好気・嫌気ボトル検出パターンに関する検討

    平田 和成, 金森 肇, 馬場 啓聡, 勝見 真琴, 大島 謙吾, 青柳 哲史, 徳田 浩一

    感染症学雑誌　94　(2)　275-275　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  67. 東南アジアで獲得したメタロβ-ラクタマーゼ産生多剤耐性緑膿菌による髄膜炎の1例 Peer-reviewed

    馬場 啓聡, 金森 肇, 鈴木 由希, 中野 竜一, 大江 千紘, 大島 謙吾, 青柳 哲史, 徳田 浩一, 矢野 寿一, 賀来 満夫

    感染症学雑誌　94　(2)　255-255　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

  68. 心臓血管外科術後のClostridioides difficile感染症の罹患率、患者背景、治療、及び予後についての検討 Peer-reviewed

    寺山 敬介, 本田 芳宏, 馬場 啓聡, 金森 肇, 國島 広之

    感染症学雑誌　94　(2)　257-257　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 2434-0103

  69. 敗血症における細胞外小胞体に包埋されるIL-36サイトカインの基礎的検討 Peer-reviewed

    青柳 哲史, 馬場 啓聡, 金森 肇, 大島 謙吾, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    感染症学雑誌　94　(2)　272-273　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

  70. グラム陰性桿菌血液培養陽性例における好気・嫌気ボトル検出パターンに関する検討 Peer-reviewed

    平田 和成, 金森 肇, 馬場 啓聡, 勝見 真琴, 大島 謙吾, 青柳 哲史, 徳田 浩一

    感染症学雑誌　94　(2)　275-275　2020/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  71. 海外からの多剤耐性緑膿菌の持ち込み症例における病室内環境調査と院内伝播防止に関する検討 Peer-reviewed

    馬場 啓聡, 金森 肇, 勝美 真琴, 佐藤 貴美, 石川 恵子, 鈴木 未希, 千田 貴恵, 池田 しのぶ, 徳田 浩一

    日本環境感染学会総会プログラム・抄録集　35回　O29-5　2020/02

    Publisher: (一社)日本環境感染学会

  72. 長期間未使用病棟における水回り環境の耐性菌調査 Peer-reviewed

    石戸谷 真帆, 馬場 啓聡, 三浦 悠理子, 羽島 房子, 勝見 真琴, 阿部 裕子, 金森 肇

    日本環境感染学会総会プログラム・抄録集　35回　P62-4　2020/02

    Publisher: (一社)日本環境感染学会

  73. Ba813 harboring Bacillus cereus, genetically closely related to Bacillus anthracis, causing nosocomial bloodstream infection: Bacterial virulence factors and clinical outcome. International-journal Peer-reviewed

    Tetsuji Aoyagi, Kengo Oshima, Shiro Endo, Hiroaki Baba, Hajime Kanamori, Makiko Yoshida, Koichi Tokuda, Mitsuo Kaku

    PloS one　15　(7)　e0235771　2020

    DOI： 10.1371/journal.pone.0235771 　

    More details Close

    Bacillus cereus commonly causes catheter-related bloodstream infections (BSIs) in hospital settings, and occasionally occurs fatal central nervous system (CNS) complications. B. cereus harboring Ba813, a specific chromosomal marker of Bacillus anthracis, has been found in patients with severe infection and nosocomial BSI. However, the bacteriological profile and clinical feature of Ba813 (+) B. cereus are unclear. Fifty-three patients with B. cereus BSI were examined. Isolates were evaluated for Ba813, B. anthracis-related and food poisoning-related virulence, multilocus sequencing typing, and biofilm formation. Patients' clinical records were reviewed retrospectively. The 53 isolates were comprised of 29 different sequence types in two distinct clades. Seventeen of the 53 (32%) B. cereus isolates including five sequence types possessed Ba813 and were classified into Clade-1/Cereus-III lineage which is most closely related to Anthracis lineage. No B. cereus possessed B. anthracis-related virulence genes. Ba813 (+) strains showed a lower prevalence of enterotoxin genes than Clade-2 strains (n = 4), but no difference from Clade-1. Ba813 (+) strains showed significantly lower biofilm formation than Clade-1/non-Cereus-III (n = 22) and Clade-2 strains, respectively. Compared to Clade-1/non-Cereus-III and Clade-2 B. cereus, Ba813 (+) strains were isolated more frequently from elderly patients, patients with indwelling central venous catheter rather than peripheral venous catheter, and patients who remained in the hospital for longer before BSI onset. No significant differences in disease severity or mortality were observed. Though two of the ten Ba813 (-) strains in Clade-1/Cereus III were isolated from the patients with CNS complication, no significant difference was observed in the bacterial profile and clinical characteristics among Clade-1/Cereus III strains. In conclusion, our report suggested that Ba813-harboring B. cereus strains, genetically closely related to B. anthracis, were abundant among B. cereus strains in the hospital setting, and might cause catheter-related nosocomial BSI. However, it did not affect the clinical outcomes.

  74. 志賀毒素産生性大腸菌臨床分離株の分子疫学的特徴 Peer-reviewed

    馬場 啓聡, 金森 肇, 岡 健太郎, 高橋 志達, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    感染症学雑誌　93　(臨増)　367-367　2019/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  75. Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan. International-journal Peer-reviewed

    Hiroaki Baba, Hajime Kanamori, Hayami Kudo, Yasutoshi Kuroki, Seiya Higashi, Kentaro Oka, Motomichi Takahashi, Makiko Yoshida, Kengo Oshima, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

    PloS one　14　(11)　e0225340　2019

    DOI： 10.1371/journal.pone.0225340 　

    More details Close

    Shiga toxin-producing Escherichia coli (STEC) can cause severe gastrointestinal disease and colonization among food handlers. In Japan, STEC infection is a notifiable disease, and food handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of STEC is not entirely known. We investigated the genomic characteristics of STEC from patients and asymptomatic food handlers in Miyagi Prefecture, Japan. Whole-genome sequencing (WGS) was performed on 65 STEC isolates obtained from 38 patients and 27 food handlers by public health surveillance in Miyagi Prefecture between April 2016 and March 2017. Isolates of O157:H7 ST11 and O26:H11 ST21 were predominant (n = 19, 29%, respectively). Non-O157 isolates accounted for 69% (n = 45) of all isolates. Among 48 isolates with serotypes found in the patients (serotype O157:H7 and 5 non-O157 serotypes, O26:H11, O103:H2, O103:H8, O121:H19 and O145:H28), adhesion genes eae, tir, and espB, and type III secretion system genes espA, espJ, nleA, nleB, and nleC were detected in 41 to 47 isolates (85-98%), whereas isolates with other serotypes found only in food handlers were negative for all of these genes. Non-O157 isolates were especially prevalent among patients younger than 5 years old. Shiga-toxin gene stx1a, adhesion gene efa1, secretion system genes espF and cif, and fimbrial gene lpfA were significantly more frequent among non-O157 isolates from patients than among O157 isolates from patients. The most prevalent resistance genes among our STEC isolates were aminoglycoside resistance genes, followed by sulfamethoxazole/trimethoprim resistance genes. WGS revealed that 20 isolates were divided into 9 indistinguishable core genomes (<5 SNPs), demonstrating clonal expansion of these STEC strains in our region, including an O26:H11 strain with stx1a+stx2a. Non-O157 STEC with multiple virulence genes were prevalent among both patients and food handlers in our region of Japan, highlighting the importance of monitoring the genomic characteristics of STEC.

  76. The first case report of septic abortion resulting from β-lactamase-negative ampicillin-resistant non-typeable Haemophilus influenzae infection. International-journal Peer-reviewed

    Hiroaki Baba, Risako Kakuta, Hasumi Tomita, Minako Miyazoe, Masatoshi Saito, Chihiro Oe, Noriomi Ishibashi, Misa Sogi, Kengo Oshima, Tetsuji Aoyagi, Yoshiaki Gu, Makiko Yoshida, Koichi Tokuda, Shiro Endo, Hisakazu Yano, Mitsuo Kaku

    JMM case reports　4　(10)　e005123　2017/10

    DOI： 10.1099/jmmcr.0.005123 　

    More details Close

    Introduction. This is the first case report of septic abortion due to β-lactamase-negative ampicillin-resistant (BLNAR) non-typeable Haemophilus influenzae infection. In Japan, BLNAR H. influenzae is widespread and has become a clinical concern, especially in paediatrics and otolaryngology, but H. influenzae has not been previously recognized as a causative agent of obstetric or gynaecological infection. Case presentation. A 31-year-old pregnant woman presented at 17 weeks and 6 days of gestation with a high fever; she was admitted with a diagnosis of threatened premature delivery. Despite tocolytic treatment, she aborted spontaneously 2 h after admission and then entered septic shock. BLNAR H. influenzae was detected in both blood and vaginal cultures. Her condition gradually improved after several days of treatment with cefotaxime, and she was ultimately discharged without sequelae or complaints. Conclusion. Although penicillin with a β-lactamase inhibitor is currently recommended for the treatment of septic abortion, this combination will probably lead to treatment failure in the case of BLNAR H. influenzae infection. As this study reveals, H. influenzae can cause septic abortion; hence, future efforts should be undertaken to detect and therapeutically target this pathogen during pregnancy.

  77. Trivalent inactivated influenza vaccine effective against influenza A(H3N2) variant viruses in children during the 2014/15 season, Japan. International-journal Peer-reviewed

    Norio Sugaya, Masayoshi Shinjoh, Chiharu Kawakami, Yoshio Yamaguchi, Makoto Yoshida, Hiroaki Baba, Mayumi Ishikawa, Mio Kono, Shinichiro Sekiguchi, Takahisa Kimiya, Keiko Mitamura, Motoko Fujino, Osamu Komiyama, Naoko Yoshida, Kenichiro Tsunematsu, Atsushi Narabayashi, Yuji Nakata, Akihiro Sato, Nobuhiko Taguchi, Hisayo Fujita, Machiko Toki, Michiko Myokai, Ichiro Ookawara, Takao Takahashi

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin　21　(42)　2016/10/20

    Publisher: European Centre for Disease Prevention and Control (ECDC)

    DOI： 10.2807/1560-7917.ES.2016.21.42.30377 　

    ISSN： 1560-7917 1025-496X

  78. 当院で経験した小児における市中感染MRSA皮下膿瘍について

    馬場 啓聡, 佐藤 吉壮, 山藤 満, 花木 秀明, 崔 龍洙

    日本化学療法学会雑誌　63　(Suppl.A)　165-165　2015/05

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  79. Nationwide survey of the development of drug resistance in the pediatric field in 2007, 2010, and 2012: drug sensitivity of Haemophilus influenzae serotype b strain in Japan. International-journal Peer-reviewed

    Hiroaki Baba, Yoshitake Sato, Yoshikiyo Toyonaga, Hideaki Hanaki, Keisuke Sunakawa

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　21　(4)　277-83　2015/04

    DOI： 10.1016/j.jiac.2014.12.006 　

    ISSN： 1341-321X

    eISSN： 1437-7780

  80. Effectiveness of Trivalent Inactivated Influenza Vaccine in Children Estimated by a Test-Negative Case-Control Design Study Based on Influenza Rapid Diagnostic Test Results. International-journal Peer-reviewed

    Masayoshi Shinjoh, Norio Sugaya, Yoshio Yamaguchi, Yuka Tomidokoro, Shinichiro Sekiguchi, Keiko Mitamura, Motoko Fujino, Hiroyuki Shiro, Osamu Komiyama, Nobuhiko Taguchi, Yuji Nakata, Naoko Yoshida, Atsushi Narabayashi, Michiko Myokai, Masanori Sato, Munehiro Furuichi, Hiroaki Baba, Hisayo Fujita, Akihiro Sato, Ichiro Ookawara, Kenichiro Tsunematsu, Makoto Yoshida, Mio Kono, Fumie Tanaka, Chiharu Kawakami, Takahisa Kimiya, Takao Takahashi, Satoshi Iwata

    PloS one　10　(8)　e0136539　2015

    DOI： 10.1371/journal.pone.0136539 　

    ISSN： 1932-6203

  81. EB VIRUS ASSOCIATED HLH: WHAT IS THE HALLMARK OF RESOLUTION? Peer-reviewed

    Fumito Yamazaki, Toshiji Shitara, Hiroaki Baba, Naoko Miyaji, Hideyuki Hori, Tomo Natsumeda, Yoshitake Sato, Ken-Ichi Imadome

    PEDIATRIC BLOOD & CANCER　56　(4)　700-700　2011/04

    ISSN： 1545-5009

Show all ︎Show first 5

Misc. 100

  1. できていますか?医療施設の水回り環境の感染対策

    馬場啓聡, 馬場啓聡, 金森肇

    Medical Technology　52　(12)　2024

    ISSN： 0389-1887

  2. Comparison of Prevalence of Antibiotic-Resistance Bacteria in Municipal Wastewater before and after COVID-19 Pandemic

    西山正晃, 遠藤敬大, 渡部徹, 馬場啓聡, 金森肇

    日本水環境学会年会講演集　58th　2024

  3. iNFECTiON CONTROL★TOPiC★「何が起こってる?」「何が変わる?変わらない?」に答えます! ICTが注意しておくべき海外で流行する感染症と輸入感染症対策

    馬場 啓聡, 金森 肇

    INFECTION CONTROL　32　(7)　652-659　2023/07

    Publisher: (株)メディカ出版

    ISSN： 0919-1011

  4. 環境制御が有用な病原体—特集 環境感染制御の技術動向(2)

    馬場 啓聡, 金森 肇

    クリーンテクノロジー = Clean technology : クリーン環境と清浄化技術の専門誌 / クリーンテクノロジー編集部 編　33　(4)　26-30　2023/04

    Publisher: 日本工業出版

    ISSN： 0917-1819

  5. 下水由来のカルバペネマーゼ産生グラム陰性菌のゲノム解析

    馬場 啓聡, 金森 肇, 西山 正晃, 武井 祐美子, 渡部 徹

    日本化学療法学会雑誌　71　(2)　171-171　2023/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  6. 潰瘍性大腸炎治療中にリステリア菌血症を発症した一例

    郷 愛太, 大島 謙吾, 馬場 啓聡, 徳田 浩一, 金森 肇

    日本化学療法学会雑誌　71　(2)　175-175　2023/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  7. 東北大学病院における持続的菌血症の検討

    北谷 栞, 金森 肇, 大島 謙吾, 馬場 啓聡, 武井 健太郎, 清家 一生, 勝見 真琴, 徳田 浩一

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-087　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  8. 新型コロナウイルスとLegionella pneumophilaの共感染による重症肺炎で太平洋上の貨物船から医療搬送された一例

    北谷 栞, 馬場 啓聡, 大島 謙吾, 武井 健太郎, 清家 一生, 徳田 浩一, 中山 麻美, 金森 肇

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-143　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  9. HSVによる肝炎発症後,産褥期にElsberg症候群を発症した一症例

    北村 知穂, 武井 健太郎, 清家 一生, 馬場 啓聡, 金森 肇, 大島 謙吾, 徳田 浩一

    日本感染症学会総会・学術講演会・日本化学療法学会学術集会合同学会プログラム・抄録集　97回・71回　O-181　2023/03

    Publisher: 日本感染症学会・日本化学療法学会

  10. Salmonella Enteritidisによる人工弁感染性心内膜炎に大動脈弁輪部膿瘍を合併した一例

    北谷栞, 北谷栞, 馬場啓聡, 徳田浩一, 金森肇

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　72nd-70th　2023

  11. マルチプレックス・ハイブリッドキャプチャー法による病院排水中の薬剤耐性遺伝子の検出

    馬場啓聡, 金森肇

    日本環境感染学会総会・学術集会(Web)　38th　2023

  12. 複数の遺伝子型によるNICU・GCUのMRSA集積事例の対応

    北村知穂, 北村知穂, 金森肇, 金森肇, 馬場啓聡, 鈴木博也, 千田貴恵, 遠藤春樹, 千葉美紀子, 池田しのぶ, 徳田浩一, 徳田浩一

    日本環境感染学会総会・学術集会(Web)　38th　2023

  13. 電気集塵式ウイルスサンプラーを用いた空気中のSARS-CoV-2の検出

    馬場啓聡, 曽根原弘樹, 金森肇, 徳田浩一, 水野彰, 水野彰

    日本環境感染学会総会・学術集会(Web)　38th　2023

  14. カタル期の鼻硬化腫の一例 その所見と治療経過について

    松田 信作, 大塚 喜人, 渡 智久, 阿部 桂子, 児玉 真, 馬場 啓聡, 高井 禎成

    日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　783-783　2022/04

    Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN： 2436-5793

    eISSN： 2436-5866

  15. Clinical features of patients with COVID-19 relapsed following cessation of corticosteroid therapy

    村上康司, 佐野寛仁, 東出直樹, 佐藤慶, 徳田浩一, 大島謙悟, 金森肇, 馬場啓聡, 武井健太郎, 玉田勉, 杉浦久敏

    日本呼吸器学会誌(Web)　11　2022

    ISSN： 2186-5884

  16. 長期のECMO管理を要したCOVID-19患者の一剖検例

    清家一生, 馬場啓聡, 武井健太郎, 金森肇, 金森肇, 大島謙吾, 徳田浩一, 徳田浩一

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　71st-69th　2022

  17. 東北大学病院における腸内細菌目細菌による持続的菌血症の検討

    北谷栞, 北谷栞, 金森肇, 大島謙吾, 馬場啓聡, 武井健太郎, 清家一生, 勝見真琴, 徳田浩一

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　71st-69th　2022

  18. 当院の新型コロナウイルス変異株の検出状況および感染性リスク評価における発症日とCt値の関連性

    中山麻美, 岡本道子, 馬場啓聡, 金森肇, 押谷仁

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　71st-69th　2022

  19. 【COVID-19と腎臓病】【診断・治療】各種変異株の特徴と対処法

    馬場 啓聡

    腎と透析　92　(1)　147-151　2022/01

    Publisher: (株)東京医学社

    ISSN： 0385-2156

  20. すぐに講義ができるパワポスライドつき!コロナ禍のリモート研修で参加者を惹きつけるコツ 第3章 すぐに使えるパワポつき!惹きつける講義コンテンツ 洗浄・消毒・滅菌のポイント

    馬場啓聡, 馬場啓聡, 金森肇, 金森肇

    Infection Control　31　(8)　792-796　2022

    Publisher: (株)メディカ出版

    ISSN： 0919-1011

  21. 環境中における薬剤耐性菌及び抗微生物剤の調査法等の確立のための研究 医療と環境の薬剤耐性に関する研究

    金森肇, 馬場啓聡, 勝見真琴, 渡部徹, 西山正晃

    環境中における薬剤耐性菌及び抗微生物剤の調査法等の確立のための研究 令和2年度 総括・分担研究報告書(Web)　2021

  22. 都市下水と病院排水中の腸内細菌科細菌が保有するESBL産生遺伝子の特徴—MOLECULAR CHARACTERIZATION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GENES OF ENTEROBACTERIACEAE ISOLATED FROM MUNCIPAL AND HOSPITAL WASTEWATERS

    森 祐哉, 西山 正晃, 澁木 理央, 馬場 啓聡, 金森 肇, 渡部 徹

    環境工学研究論文集 = Environmental research / 土木学会環境工学委員会 編　58　Ⅲ_199-207　2021

    Publisher: 土木学会

    ISSN： 1341-5115

  23. MOLECULAR CHARACTERIZATION OF EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GENES OF ENTEROBACTERIACEAE ISOLATED FROM MUNCIPAL AND HOSPITAL WASTEWATERS

    森祐哉, 西山正晃, 澁木理央, 馬場啓聡, 金森肇, 渡部徹

    土木学会論文集 G(環境)(Web)　77　(7)　2021

    ISSN： 2185-6648

  24. Characterization of Vancomycin-Resistant Enterococci Isolated from Municipal Wastewater in Japan

    西山正晃, 甲高綾乃, 渡部徹, 金森肇, 馬場啓聡

    日本水環境学会シンポジウム講演集　24th　2021

  25. Genetic Characteristics of Extended Spectrum Beta-Lactamase Producing Escherichia coli Isolated from Municipal and Hospital Wastewaters

    渡部徹, 西山正晃, 澁木理央, 金森肇, 馬場啓聡

    日本水環境学会シンポジウム講演集　24th　2021

  26. Molecular epidemiological investigation of methicillin-resistant Staphylococcus aureus isolated from municipal wastewater

    西山正晃, 渡部徹, 馬場啓聡, 金森肇

    日本水環境学会年会講演集　55th　2021

  27. 担癌患者および自己免疫疾患患者における緑膿菌による前立腺膿瘍の2例

    清家一生, 金森肇, 金森肇, 金森肇, 武井健太郎, 新妻郁未, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史

    日本化学療法学会雑誌　69　(Supplement-A)　2021

    ISSN： 1340-7007

  28. Good症候群に伴うサイトメガロウイルス網膜炎の一例

    武井健太郎, 金森肇, 金森肇, 金森肇, 清家一生, 新妻郁未, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史, 青柳哲史

    日本化学療法学会雑誌　69　(Supplement-A)　2021

    ISSN： 1340-7007

  29. 発熱と皮疹を主訴としたCOVID-19の2例

    清家一生, 金森肇, 金森肇, 金森肇, 馬場啓聡, 馬場啓聡, 新妻郁未, 武井健太郎, 大島謙吾, 大島謙吾, 徳田浩一, 徳田浩一, 徳田浩一, 青柳哲史, 青柳哲史

    日本化学療法学会雑誌　69　(Supplement-A)　2021

    ISSN： 1340-7007

  30. Rhodotorula mucilaginosaによるカテーテル関連血流感染症の1例

    佐藤裕真, 佐藤裕真, 金森肇, 清家一生, 新妻郁未, 武井健太郎, 馬場啓聡, 大島謙吾, 徳田浩一, 青柳哲史

    日本化学療法学会雑誌　69　(Supplement-A)　2021

    ISSN： 1340-7007

  31. エクリズマブ投与患者における播種性淋菌感染症の1例

    新妻郁未, 金森肇, 金森肇, 金森肇, 清家一生, 武井健太郎, 馬場啓聡, 馬場啓聡, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 徳田浩一, 徳田浩一, 徳田浩一

    日本化学療法学会雑誌　69　(Supplement-A)　2021

    ISSN： 1340-7007

  32. 「環境中における薬剤耐性菌及び抗微生物剤の調査法等の確立のための研究」「医療と環境の薬剤耐性に関する研究」

    金森肇, 馬場啓聡, 勝見真琴, 黒田誠, 関塚剛史

    環境中における薬剤耐性菌及び抗微生物剤の調査法等の確立のための研究 令和元年度 総括・分担研究報告書(Web)　2020

  33. A Survey on Prevalence of Antibiotic Resistant Bacteria by Monitoring Municipal and Hospital Wastewaters

    渡部徹, 西山正晃, 森祐哉, 澁木理央, 金森肇, 馬場啓聡

    日本水環境学会シンポジウム講演集　23rd　2020

  34. 病院排水中の耐性菌のモニタリング-都市下水との比較で分かること

    渡部徹, 西山正晃, 澁木理央, 森祐哉, 金森肇, 馬場啓聡

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　69th-67th　(1)　50-51　2020

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  35. Streptococcus gallolyticus subsp. gallolyticusによる敗血症の一例

    勝見 真琴, 馬場 啓聡, 佐藤 亜耶, 佐藤 敦子, 三浦 悠理子, 佐藤 貴美, 千葉 美紀子, 石戸谷 真帆, 羽島 房子, 庄司 淳子, 阿部 裕子, 藤巻 慎一

    日本臨床微生物学会雑誌　30　(Suppl.1)　256-256　2019/12

    Publisher: (一社)日本臨床微生物学会

    ISSN： 2434-866X

  36. 都市下水のモニタリングによる薬剤耐性菌のまん延調査:病院排水との比較

    渡部徹, 西山正晃, 鶴巻啓一, 金森肇, 馬場啓聡

    日本水環境学会シンポジウム講演集　22nd　55　2019/09/05

  37. 志賀毒素産生性大腸菌臨床分離株の分子疫学的特徴

    馬場啓聡, 金森肇, 岡健太郎, 岡健太郎, 高橋志達, 高橋志達, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

    感染症学雑誌　93　(臨増)　367-367　2019/03/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

  38. Candida菌血症の予後改善のためのCandida Care Bundle評価

    新妻 郁未, 青柳 哲史, 馬場 啓聡, 金森 肇, 大島 謙吾, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    日本化学療法学会雑誌　67　(Suppl.A)　256-256　2019/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  39. Candida菌血症の予後改善のためのCandida Care Bundle評価

    新妻 郁未, 青柳 哲史, 馬場 啓聡, 金森 肇, 大島 謙吾, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    日本化学療法学会雑誌　67　(Suppl.A)　256-256　2019/03

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

  40. 東南アジアで獲得したメタロβ-ラクタマーゼ産生多剤耐性緑膿菌による髄膜炎の一例

    馬場啓聡, 馬場啓聡, 金森肇, 金森肇, 鈴木由希, 中野竜一, 大江千紘, 大江千紘, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 徳田浩一, 徳田浩一, 矢野寿一, 賀来満夫, 賀来満夫, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　68th-66th　2019

  41. A case of bacteremia caused by Methylobacterium radiotolerans

    29　(3)　152-157　2019

    Publisher: 日本臨床微生物学会

    ISSN： 2434-866X

  42. Clostridioides difficile infection after cardiovascular surgery: morbidity, background, treatment, and prognosis

    寺山敬介, 本田芳宏, 馬場啓聡, 金森肇, 國島広之

    日本外科感染症学会雑誌(Web)　16　(3)　180‐184(J‐STAGE)-184　2019

    Publisher: Japan Society for Surgical Infection

    DOI： 10.24679/gekakansen.16.3_180 　

    ISSN： 2434-0103

    eISSN： 2434-0103

    More details Close

    Clostridioides difficile infection (CDI) is a serious medical issue. Even though CDI can particularly be a problem when it occurs postoperatively, its occurrence following cardiovascular surgery remains to be investigated in Japan. The purpose of this study was to investigate CDI following cardiovascular surgery at Sendai Kosei Hospital. Postoperative CDI during the 5-year period spanning January 2013 to December 2017 was investigated. Overall morbidity due to postoperative CDI in patients in the cardiovascular surgery department was significantly lower than that among those hospitalized in the others (35/63,342 versus 659/778,017，P=0.01). The time to development of CDI tended to be shorter in patients with extracorporeal circulation and those undergoing Y-graft substitution procedures. Multicenter investigations employing larger patient samples are needed to clarify the status of CDI after cardiovascular surgery.

  43. ディスク法によるSerratia marcescensのESBL産生性の評価

    馬場 啓聡, 金森 肇, 遠藤 史郎, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 矢野 寿一, 賀来 満夫

    感染症学雑誌　93　(1)　74-74　2019/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  44. 宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

    馬場 啓聡, 金森 肇, 工藤 逸美, 岡 健太郎, 高橋 志達, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    日本臨床腸内微生物学会誌　21　(1)　56-56　2019

    Publisher: 日本臨床腸内微生物学会

  45. Clostridioides difficile infection after cardiovascular surgery: morbidity, background, treatment, and prognosis

    Terayama Keisuke, Honda Yoshihiro, Baba Hiroaki, Kanamori Hajime, Kunishima Hiroyuki

    Journal of Japan Society for Surgical Infection　16　(3)　180-184　2019

    Publisher: Japan Society for Surgical Infection

    DOI： 10.24679/gekakansen.16.3_180 　

    ISSN： 1349-5755

    eISSN： 2434-0103

  46. 急性期病院で分離されたカルバペネム耐性腸内細菌科細菌(CRE)の解析

    牧野 祐子, 金森 肇, 遠藤 史郎, 馬場 啓聡, 大江 千紘, 吉田 眞紀子, 大島 謙吾, 青柳 哲史, 徳田 浩一, 児玉 栄一, 矢野 寿一, 賀来 満夫

    感染症学雑誌　93　(1)　74-75　2019/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  47. Outbreak Databaseを活用した外来におけるアウトブレイクの特徴の把握

    牧野 祐子, 金森 肇, 徳田 浩一, 大江 千紘, 馬場 啓聡, 吉田 眞紀子, 大島 謙吾, 青柳 哲史, 賀来 満夫

    感染症学雑誌　93　(1)　95-95　2019/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  48. Outbreak Databaseを活用した高齢者施設におけるアウトブレイクの疫学的特徴と傾向

    牧野 祐子, 金森 肇, 徳田 浩一, 大江 千紘, 馬場 啓聡, 吉田 眞紀子, 大島 謙吾, 青柳 哲史, 賀来 満夫

    感染症学雑誌　93　(1)　95-95　2019/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  49. O157以外の志賀毒素産生性大腸菌(non-O157 STEC)臨床分離株の分子疫学的解析

    馬場 啓聡, 金森 肇, 岡 健太郎, 高橋 志逹, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 賀来 満夫, 工藤 逸美, 黒木 靖敏, 東 聖也

    感染症学雑誌　93　(1)　99-99　2019/01

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  50. Outbreak Databaseを活用した高齢者施設におけるアウトブレイクの疫学的特徴と傾向

    牧野祐子, 牧野祐子, 金森肇, 金森肇, 徳田浩一, 徳田浩一, 大江千紘, 大江千紘, 馬場啓聡, 馬場啓聡, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　157　2018/10

  51. Outbreak Databaseを活用した外来におけるアウトブレイクの特徴の把握

    牧野祐子, 牧野祐子, 金森肇, 金森肇, 徳田浩一, 徳田浩一, 大江千紘, 大江千紘, 馬場啓聡, 馬場啓聡, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　157　2018/10

  52. ディスク法によるSerratia marcescensのESBL産生性の評価

    馬場啓聡, 金森肇, 遠藤史郎, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 矢野寿一, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　135　2018/10

  53. 急性期病院で分離されたカルバペネム耐性腸内細菌科細菌(CRE)の解析

    牧野祐子, 金森肇, 遠藤史郎, 馬場啓聡, 大江千紘, 吉田眞紀子, 大島謙吾, 青柳哲史, 徳田浩一, 児玉栄一, 矢野寿一, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　136　2018/10

  54. Listeria monocytogenes感染症12例の臨床的検討

    馬場啓聡, 金森肇, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　(1)　173-108　2018/10

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  55. O157以外の志賀毒素産生性大腸菌(non‐O157 STEC)臨床分離株の分子疫学的解析

    馬場啓聡, 金森肇, 岡健太郎, 高橋志逹, 牧野祐子, 大江千紘, 大島謙吾, 青柳哲史, 吉田眞紀子, 徳田浩一, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　67th-65th　164　2018/10

  56. 宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

    馬場 啓聡, 金森 肇, 工藤 逸美, 岡 健太郎, 高橋 志達, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　21回　28-28　2018/08

    Publisher: 日本臨床腸内微生物学会

  57. 宮城県における志賀毒素産生性大腸菌臨床分離株の分子疫学的解析

    馬場 啓聡, 金森 肇, 工藤 逸美, 岡 健太郎, 高橋 志達, 牧野 祐子, 大江 千紘, 大島 謙吾, 青柳 哲史, 吉田 眞紀子, 徳田 浩一, 賀来 満夫

    日本臨床腸内微生物学会総会・学術集会プログラム・抄録集　21回　28-28　2018/08

    Publisher: 日本臨床腸内微生物学会

  58. 日本の医療関連アウトブレイクの疫学的特徴

    金森肇, 金森肇, 徳田浩一, 徳田浩一, 牧野祐子, 大江千紘, 馬場啓聡, 藤川祐子, 北川美穂, 吉田眞紀子, 吉田眞紀子, 大島謙吾, 大島謙吾, 青柳哲史, 青柳哲史, 賀来満夫, 賀来満夫

    日本化学療法学会雑誌　66　(Supplement-A)　362-362　2018/04/25

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  59. A Case of Mycotic Aneurysm of the Abdominal Aorta Caused by Aspergillus fumigatus in a Tsunami Survivor After the East Japan Great Earthquake

    FUJIKAWA Yuko, ENDO Shiro, KAKU Mitsuo, GU Yoshiaki, OSHIMA Kengo, SOGI Misa, OE Chihiro, ISHIBASHI Noriomi, BABA Hiroaki, INOMATA Shinya, YOSHIDA Makiko

    Kansenshogaku Zasshi　92　(2)　138-143　2018

    Publisher: The Japanese Association for Infectious Diseases

    DOI： 10.11150/kansenshogakuzasshi.92.138 　

    ISSN： 0387-5911

    eISSN： 1884-569X

  60. テトラサイクリン耐性Mycoplasma hominisによる両心補助人工心臓関連感染の1例

    曽木 美佐, 大江 千紘, 馬場 啓聡, 猪股 真也, 石橋 令臣, 藤川 祐子, 大島 健吾, 具 芳明, 遠藤 史郎, 今井 悠, 鈴木 由希, 豊川 真弘, 川本 俊輔, 齋木 佳克, 賀来 満夫

    感染症学雑誌　91　(3)　476-477　2017/05

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  61. 受診時症状が軽微であった、急性喉頭蓋炎の1例

    馬場 啓聡, 賀来 満夫, 佐藤 吉壮

    日本小児科学会雑誌　121　(2)　349-349　2017/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  62. 宮城県内の医療機関より分離されたESBL産生大腸菌のキノロン耐性に関する解析

    藤川 祐子, 遠藤 史郎, 大江 千紘, 馬場 啓聡, 猪股 真也, 大島 謙吾, 具 芳明, 賀来 満夫, 小松 真由美, 渡辺 真江, 櫻井 芳明, 曽木 美佐, 吉田 眞紀子

    日本化学療法学会雑誌　65　(1)　108-109　2017/01

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  63. 腹腔鏡所見により結核性腹膜炎を早期に診断できた1例

    石橋 令臣, 大島 謙吾, 遠藤 史郎, 大江 千紘, 馬場 啓聡, 藤川 祐子, 猪股 真也, 曽木 美佐, 吉田 真紀子, 具 芳明, 賀来 満夫, 井本 博文, 田中 直樹, 海野 倫明

    結核　92　(1)　52-52　2017/01

    Publisher: (一社)日本結核病学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  64. テトラサイクリン耐性Mycoplasma hominis(M.hominis)による両心補助人工心臓関連感染の一例

    曽木美佐, 大江千紘, 馬場啓聡, 猪股真也, 石橋令臣, 藤川祐子, 大島健吾, 具芳明, 遠藤史郎, 今井悠, 鈴木由希, 豊川真弘, 川本俊輔, 齋木佳克, 賀来満夫

    日本化学療法学会西日本支部総会プログラム・講演抄録　64th　375　2016/10/13

  65. 小児インフルエンザワクチンの効果 2014〜2015年シーズン

    新庄 正宜, 菅谷 憲夫, 関口 進一郎, 三田村 敬子, 岩田 敏, 川上 千春, 山口 禎夫, 吉田 菜穂子, 楢林 敦, 木実谷 貴久, 込山 修, 馬場 啓聡, 上牧 勇, 山田 健一朗, 高橋 孝雄, 慶應小児インフルエンザ研究グループ

    感染症学雑誌　90　(3)　405-405　2016/05

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  66. 当院で分離された多剤耐性Acinetobacter gen.sp.13BJの解析

    鈴木 由希, 遠藤 史郎, 矢野 寿一, 中野 竜一, 大江 千紘, 馬場 啓聡, 斎藤 恭一, 藤川 祐子, 猪股 真也, 石橋 令臣, 曽木 美佐, 大島 謙吾, 具 芳明, 北川 美穂, 賀来 満夫

    日本化学療法学会雑誌　64　(Suppl.A)　183-183　2016/05

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  67. 宮城県における成人侵襲性肺炎球菌感染症の由来菌株の血清型分布についての検討

    大島 謙吾, 青柳 哲史, 鈴木 由希, 馬場 啓聡, 斎藤 恭一, 藤川 祐子, 曽木 美佐, 具 芳明, 遠藤 史郎, 大石 和徳, 賀来 満夫

    日本化学療法学会雑誌　64　(Suppl.A)　203-203　2016/05

    Publisher: (公社)日本化学療法学会

    ISSN： 1340-7007

    eISSN： 1884-5886

  68. 血液培養と遺伝子解析法とで異なる微生物が検出された感染性心内膜炎の1例

    斎藤 恭一, 鈴木 由希, 馬場 啓聡, 藤川 祐子, 今井 悠, 猪股 真也, 石橋 令臣, 曽木 美佐, 大島 謙吾, 具 芳明, 遠藤 史郎, 川本 俊輔, 齋木 佳克, 賀来 満夫

    感染症学雑誌　90　(3)　419-419　2016/05

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  69. 東北大学病院において喀痰から分離されたAcinetobacter spp.の菌種レベルでの分離頻度と薬剤耐性機序の解析

    鈴木 由希, 遠藤 史郎, 馬場 啓聡, 斎藤 恭一, 藤川 祐子, 今井 悠, 猪股 真也, 石橋 令臣, 大江 千紘, 曽木 美佐, 大島 謙吾, 具 芳明, 吉田 眞紀子, 中島 一敏, 北川 美穂, 賀来 満夫

    感染症学雑誌　90　(3)　422-422　2016/05

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  70. A型肝炎の1歳児例

    馬場 啓聡, 賀来 満夫, 佐藤 吉壮

    感染症学雑誌　90　(臨増)　308-308　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  71. 東北大学病院において喀痰から分離されたカルバペネム耐性Acinetobacter spp.の特徴について

    鈴木 由希, 遠藤 史郎, 矢野 寿一, 中野 竜一, 小澤 大樹, 馬場 啓聡, 今井 悠, 斎藤 恭一, 藤川 祐子, 猪股 真也, 石橋 令臣, 大江 千紘, 曽木 美佐, 大島 謙吾, 具 芳明, 吉田 眞紀子, 中島 一敏, 北川 美穂, 賀来 満夫

    感染症学雑誌　90　(臨増)　262-262　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  72. 本邦におけるThe FilmArray Blood Culture Identification Panelの性能評価

    斎藤 恭一, 遠藤 史郎, 猪股 真也, 藤川 祐子, 鈴木 由希, 今井 悠, 馬場 啓聡, 大江 千紘, 小澤 大樹, 石橋 令臣, 曽木 美佐, 吉田 眞紀子, 大島 謙吾, 具 芳明, 中島 一敏, 賀来 満夫

    感染症学雑誌　90　(臨増)　284-284　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  73. 7価結合型肺炎球菌ワクチン導入後に本邦の小児急性中耳炎症例から分離された肺炎球菌の分子疫学的解析

    小澤 大樹, 矢野 寿一, 遠藤 史郎, 角田 梨紗子, 猪股 真也, 鈴木 由希, 斎藤 恭一, 藤川 祐子, 馬場 啓聡, 賀来 満夫

    感染症学雑誌　90　(臨増)　369-369　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  74. 抗菌薬の使用状況と耐性に関するグローバル時点有病率調査(GLOBAL-PPS)の当院の結果と抗菌薬適正使用プログラムへの応用の検討

    曽木 美佐, 具 芳明, 今井 悠, 馬場 啓聡, 大江 千紘, 斎藤 恭一, 藤川 祐子, 鈴木 由希, 石橋 令臣, 猪股 真也, 大島 謙吾, 吉田 眞紀子, 遠藤 史郎, 中島 一敏, 賀来 満夫

    感染症学雑誌　90　(臨増)　382-382　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  75. アスペルギルスによる感染性腹部大動脈瘤の1例

    藤川 祐子, 具 芳明, 大島 謙吾, 曽木 美佐, 大江 千紘, 石橋 令臣, 馬場 啓聡, 今井 悠, 猪股 真也, 吉田 眞紀子, 遠藤 史郎, 中島 一敏, 賀来 満夫, 後藤 均, 清水 拓也

    感染症学雑誌　90　(臨増)　325-325　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  76. 嫌気性菌による感染性腹部大動脈瘤の2例

    大江 千紘, 藤川 祐子, 今井 悠, 馬場 啓聡, 鈴木 由希, 斎藤 恭一, 石橋 令臣, 猪股 真也, 曽木 美佐, 大島 謙吾, 具 芳明, 吉田 眞紀子, 遠藤 史郎, 中島 一敏, 川本 俊輔, 齋木 佳克, 賀来 満夫, 後藤 均, 清水 拓也

    感染症学雑誌　90　(臨増)　377-377　2016/03

    Publisher: (一社)日本感染症学会

    ISSN： 0387-5911

    eISSN： 1884-569X

  77. 健康小児に発症した、市中感染偽膜性腸炎の一例

    馬場 啓聡, 草野 知江子, 賀来 満夫, 佐藤 吉壮

    日本小児科学会雑誌　120　(2)　237-237　2016/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  78. ヘモグロビン2.2g/dLで発見されたDiamond-Blackfan貧血の1例

    野ヶ山 泰介, 後藤 安那, 浅田 礼光, 冨永 尚宏, 畑岸 達也, 馬場 啓聡, 山崎 あずさ, 草野 知江子, 嶋田 博之, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　119　(8)　1285-1285　2015/08

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  79. 発熱、下痢時の脱力と手足の痺れが発見の契機となったGitelman症候群の1例

    冨永 尚宏, 後藤 安那, 浅田 礼光, 野々山 泰介, 畑岸 達也, 馬場 啓聡, 山崎 あずさ, 宮地 尚子, 草野 知江子, 野津 寛大, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　119　(8)　1285-1286　2015/08

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  80. 迅速診断を用いた小児インフルエンザワクチンの効果 test-negative case-control study

    新庄 正宜, 菅谷 憲夫, 関口 進一郎, 岩田 敏, 高橋 孝雄, 佐藤 清二, 上牧 務, 佐藤 公則, 常松 健一郎, 馬場 啓聡, 藤野 元子, 古市 宗弘, 豊間 博, 宮入 烈, 明貝 路子, 山口 禎夫, 吉田 菜穂子, 慶應小児インフルエンザ研究グループ

    小児感染免疫　27　(2)　143-143　2015/07

    Publisher: (一社)日本小児感染症学会

    ISSN： 0917-4931

  81. 良性家族性新生児痙攣の母子例

    畑岸 達也, 後藤 安那, 浅田 礼光, 野ヶ山 泰介, 冨永 尚宏, 山崎 あずさ, 馬場 啓聡, 宮路 尚子, 堀 秀之, 草野 知江子, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　119　(3)　639-640　2015/03

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  82. プレドニゾロン使用中に急激な巨大脂肪肝を呈したネフローゼ症候群の一例(Prednisolone-induced acute massive hepatic steatosis in a nephrotic patient)

    浅田 礼光, 堀 尚明, 冨永 尚宏, 畑岸 達也, 馬場 啓聡, 宮路 尚子, 草野 知江子, 石井 智弘, 粟津 緑, 佐藤 吉壮

    日本小児科学会雑誌　119　(2)　227-227　2015/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  83. エリスロポエチンと相関して間欠熱を認めた自己免疫性溶血性貧血の一例(High erythropoietin-associated fever in a girl with autoimmune hemolytic anemia)

    浅田 礼光, 堀 尚明, 野ヶ山 泰介, 冨永 尚宏, 馬場 啓聡, 草野 知江子, 宮路 尚子, 嶋田 博之, 粟津 緑, 佐藤 吉壮

    日本小児科学会雑誌　119　(2)　228-228　2015/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  84. 片側のCandida真菌球により急性腎不全を発症した総排泄腔症の新生児例(Acute renal failure by unilateral Candida fungus ball in a neonate with cloaca)

    馬場 啓聡, 浅田 礼光, 宮路 尚子, 森村 敏哉, 志関 孝夫, 青柳 順, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　119　(2)　236-236　2015/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  85. 血液培養と遺伝子解析法とで異なる微生物が検出された感染性心内膜炎の一例

    斎藤恭一, 斎藤恭一, 鈴木由希, 馬場啓聡, 馬場啓聡, 藤川祐子, 藤川祐子, 今井悠, 今井悠, 猪股真也, 猪股真也, 石橋令臣, 石橋令臣, 曽木美佐, 曽木美佐, 大島謙吾, 大島謙吾, 具芳明, 具芳明, 遠藤史郎, 遠藤史郎, 川本俊輔, 齋木佳克, 賀来満夫, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　64th-62nd　2015

  86. 東北大学病院において喀痰から分離されたAcinetobacter spp.の菌種レベルでの分離頻度と薬剤耐性機序の解析

    鈴木由希, 遠藤史郎, 馬場啓聡, 斎藤恭一, 藤川祐子, 今井悠, 猪股真也, 石橋令臣, 大江千紘, 曽木美佐, 大島謙吾, 具芳明, 吉田眞紀子, 中島一敏, 北川美穂, 賀来満夫

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　64th-62nd　162　2015

  87. 1型糖尿病患児における持続血糖モニターの有用性

    後藤 安那, 畑岸 達也, 浅田 礼光, 太田 みのり, 山崎 あずさ, 馬場 啓聡, 堀 秀之, 草野 知江子, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　118　(9)　1397-1397　2014/09

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  88. アシクロビル耐性ヘルペス脳炎を疑った新生児の1例

    畑岸 達也, 浅田 礼光, 太田 みのり, 山崎 あづさ, 馬場 啓聡, 堀 秀之, 草野 知江子, 草野 亮祐, 富田 桂子, 澤浦 法子, 荒川 浩一, 堀 尚明, 佐藤 吉壮

    日本小児科学会雑誌　118　(6)　981-981　2014/06

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  89. 腎機能障害の患者が薬剤使用中であった場合、間質性腎炎を疑う必要がある

    浅田 礼光, 堀 尚明, 山崎 あずさ, 太田 みのり, 畑岸 達也, 馬場 啓聡, 堀 秀之, 草野 知江子, 佐藤 吉壮

    日本小児科学会雑誌　118　(6)　984-984　2014/06

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  90. アレルギー素因を持つ薬剤性急性間質性腎炎の一例

    浅田 礼光, 堀 尚明, 山崎 あずさ, 太田 みのり, 畑岸 達也, 馬場 啓聡, 堀 秀之, 草野 知江子, 粟津 緑, 佐藤 吉壮

    日本小児科学会雑誌　118　(2)　421-421　2014/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  91. Granulicatella adiacensによる感染性心内膜炎(IE)の1例

    馬場 義郎, 山崎 あずさ, 畑岸 達也, 馬場 啓聡, 堀 秀之, 草野 知江子, 草野 亮祐, 中山 晶子, 山極 健秋, 山藤 満, 佐藤 吉壮

    日本小児科学会雑誌　117　(8)　1326-1326　2013/08

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  92. 小児由来のMRSAに対する各種抗菌薬のin vitro併用効果 抗MRSA薬vsカルバペネム系抗菌薬

    馬場 啓聡, 佐藤 吉壮, 山藤 満, 岩田 敏, 秋田 博伸, 砂川 慶介

    小児感染免疫　25　(1)　79-80　2013/04

    Publisher: (一社)日本小児感染症学会

    ISSN： 0917-4931

  93. 小児由来のMRSAに対する各種抗菌薬のin vitro併用効果 FOM+FMOX、CTM+PAPM、CTM+MEPMについて

    山藤 満, 馬場 啓聡, 佐藤 吉壮, 岩田 敏, 秋田 博伸, 砂川 慶介

    小児感染免疫　25　(1)　80-80　2013/04

    Publisher: (一社)日本小児感染症学会

    ISSN： 0917-4931

  94. 目で見る小児科 軽度の仙骨部皮膚陥凹から発見された潜在性二分脊椎の1例

    堀 秀之, 設楽 利二, 畑岸 達也, 馬場 啓聡, 宮路 尚子, 山崎 文登, 石井 とも, 佐藤 吉壮, 加藤 克哉, 矢尾板 裕之

    小児科　52　(7)　939-940　2011/06

    Publisher: 金原出版(株)

    ISSN： 0037-4121

  95. サラセミア・スクリーニングの試み

    山崎 文登, 設楽 利二, 馬場 啓聡, 宮路 尚子, 畑岸 達也, 堀 秀之, 石井 とも, 佐藤 吉壮, 嶋田 博之, 原野 恵子

    日本小児科学会雑誌　115　(2)　499-499　2011/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  96. サラセミア・スクリーニングの試み

    山崎 文登, 設楽 利二, 宮路 尚子, 畑岸 達也, 馬場 啓聡, 堀 秀之, 石井 とも, 佐藤 吉壮, 原野 恵子

    小児がん　47　(プログラム・総会号)　455-455　2010/12

    Publisher: (NPO)日本小児がん学会

    ISSN： 0389-4525

  97. 骨病変に著明な軟部組織病変を伴ったランゲルハンス細胞組織球症の一例

    山崎 文登, 馬場 啓聡, 宮路 尚子, 堀 秀之, 棗田 とも, 佐藤 吉壮, 設楽 利二, 木暮 修二, 織内 昇

    The Kitakanto Medical Journal　60　(2)　214-214　2010/05

    Publisher: 北関東医学会

    ISSN： 1343-2826

    eISSN： 1881-1191

  98. Usefulness of FDG-PET in Staging and Evaluation for Treatment of Langerhans Cell Histiocytosis

    YAMAZAKI Fumito, SHITARA Toshiji, BABA Hiroaki, MIYAJI Naoko, HORI Hideyuki, NATSUMEDA Tomo, SATO Yoshitake, KOGURE Shuji, KATOH Katsuya, ORIUCHI Noboru, ARAI Motohiro, NAKAZATO Yoichi

    47　(1)　105-110　2010/02/25

    Publisher: がんの子供を守る会

    ISSN： 0389-4525

  99. 学校健診で発見されたサラセミアの2例

    山崎 文登, 設楽 利二, 馬場 啓聡, 宮路 尚子, 堀 秀之, 棗田 とも, 佐藤 吉壮, 原野 恵子

    日本小児科学会雑誌　114　(2)　298-298　2010/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  100. βサラセミアの病態を呈する不安定ヘモグロビン症、ヘモグロビン群馬の1家系

    宮路 尚子, 設楽 利二, 成相 宏樹, 馬場 啓聡, 山崎 文登, 堀 秀之, 棗田 とも, 佐藤 吉壮, 原野 恵子

    小児がん　46　(プログラム・総会号)　301-301　2009/11

    Publisher: (NPO)日本小児がん学会

    ISSN： 0389-4525

Show all ︎Show first 5

Presentations 5

  1. COVID-19の病態と診断・治療のこれから Invited

    馬場啓聡, 青柳哲史

    第72回日本感染症学会東日本地方会学術集会／第70回日本化学療法学会東日本支部総会 合同学会　2023/10/26

  2. 宮城県における感染制御支援体制 Invited

    馬場啓聡, 北村知穂, 石井正, 徳田浩一

    第72回日本感染症学会東日本地方会学術集会／第70回日本化学療法学会東日本支部総会 合同学会　2023/10/25

  3. 新型コロナウイルス感染症とインフルエンザ

    馬場啓聡

    宮城野区三師会 第9回学術講演会　2023/09/30

  4. コロナのいまとこれから

    仙台市医師会市民公開講座　2023/05/18

  5. COVID-19の治療〜流行のはじまりから現在までのUP TO DATE、そして今後の展望

    馬場啓聡

    日本集中治療医学会 第6回東北支部学術集会　2022/07/02

Research Projects 2

  1. 高感度網羅的遺伝子検出法と機械学習を融合した新規薬剤耐性菌発生予測モデルの構築

    馬場 啓聡

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究

    Institution: 東北大学

    2025/04/01 - 2029/03/31

  2. ヒト・家畜・環境水に由来する志賀毒素産生性大腸菌の包括的分子疫学研究

    馬場 啓聡

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究

    Category: 若手研究

    Institution: 東北大学

    2021/04/01 - 2024/03/31

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    本邦において、致死的な志賀毒素産生性大腸菌（Shiga toxin-producing Escherichia coli；STEC）感染症の新規患者は、現在でも年間2,000～3,000人と高い水準にある。STECの自然宿主はウシを始めとした反芻動物であり、その糞便で汚染された食品や環境水を介しヒトに感染するとされているが、実際の感染例においては特に散発例について感染源及び感染経路が不明である場合が多い。一方、本邦においては、ヒト・家畜・環境水それぞれから検出されるSTECについての全ゲノムを対象とした詳細な分子疫学的検討についてはなされておらず、それらの分子レベルでの類似性・相違点については明らかでない。 本研究では、ヒトだけでなく動物を含む生態系全体の問題として感染症の対策を考える“One Health”の理念に基づき、ヒト・家畜・環境水それぞれにおけるSTEC株の分子疫学的特徴及びそれぞれの遺伝的関係性を網羅的な遺伝子解析により明らかにすることで、家畜糞便及び環境水中のSTEC株の感染伝播における役割が明らかとし、その伝播経路遮断を目的とした効果的なSTEC感染対策の確立と、新規のSTEC感染者数低減を目指す。 2021年度においては、日本のヒトに由来するSTECの分子疫学を明らかとするため、2017～2020年度に宮城県において臨床分離されたSTEC株計206株及び、検査センターで臨床検体より分離された日本全国のSTEC株計1,866株を収集・保存した。また、宮城県におけるSTECの分子疫学について、学会発表を行った（馬場啓聡。宮城県における志賀毒素産生性大腸菌の分子疫学研究。第57回宮城県公衆衛生学会学術総会。2021年9月10日Web開催）。