Details of the Researcher

PHOTO

Shinichi Morita
Section
Graduate School of Science
Job title
Associate Professor
Degree

  • 博士（理学）（関西学院大学）

  • 修士（理学）（関西学院大学）

Research History 4

  • 2013/12 - Present
    東北大学大学院理学研究科　准教授

  • 2007 - 2013/11
    理化学研究所　基礎科学特別研究員など

  • 2005 - 2007
    ジョージア大学 化学科　リサーチアソシエート

  • 2002 - 2005
    日本学術振興会 （桐蔭横浜大学）　特別研究員

Education 3

  • 関西学院大学大学院理学研究科 博士課程後期課程 修了・博士(理学)の学位取得

    - 2002/03

  • 関西学院大学大学院理学研究科 博士課程前期課程 修了

    - 1999/03

  • 関西学院大学理学部化学科卒

    - 1997/03

Research Interests 4

  • analytical chemistry

  • biopysics

  • spectral analysis

  • vibration spectroscopy

Research Areas 2

  • Nanotechnology/Materials / Analytical chemistry /

  • Natural sciences / Bio-, chemical, and soft-matter physics /

Papers 68

  1. Graphical interpretation of non-negative factorization expecting bio-Raman research Peer-reviewed

    Hua Yu, Ziteng Wang, Mana Nemoto, Kazuyuki Suzuta, Len Ito, Shin-ichi Morita

    Applied Physics Express　14　(8)　086501-086501　2021/08/01

    Publisher: IOP Publishing

    DOI： 10.35848/1882-0786/ac0fb7 　

    ISSN： 1882-0778

    eISSN： 1882-0786

  2. Bio-Raman research using principal component analysis and non-negative matrix factorization on rice grains: detections of ordered and disordered states of starch in the cooking process Peer-reviewed

    Ziteng Wang, Mengmeng He, Wulan Intan Sari, Naoki Kishimoto, Shin-ichi Morita

    Japanese Journal of Applied Physics　60　(6)　060903-060903　2021/06/01

    DOI： 10.35848/1347-4065/abff39 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  3. Automatic Determination of the Sequential Order of Dynamic Data and Its Application to Vibrational Spectroscopy Peer-reviewed

    Daisuke Miyata, Takakazu Nakabayashi, Shin-ichi Morita

    Journal of Chemical Information and Modeling　60　(10)　5070-5079　2020/10/26

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.jcim.0c00627 　

    ISSN： 1549-9596

    eISSN： 1549-960X

  4. Practical Computation of FFT-based Generalized Two-dimensional Correlation Spectroscopy Peer-reviewed

    Mengmeng HE, Daisuke MIYATA, Takakazu NAKABAYASHI, Shin-ichi MORITA

    Analytical Sciences　36　(7)　885-887　2020/07/10

    Publisher: Japan Society for Analytical Chemistry

    DOI： 10.2116/analsci.20n005 　

    ISSN： 0910-6340

    eISSN： 1348-2246

  5. Automatic removal of binary background components expecting Raman big data and its application to human hair imaging Peer-reviewed

    Akunna Francess Ujuagu, Momoko Furuta, Takakazu Nakabayashi, Len Ito, Shin-Ichi Morita

    Applied Physics Express　13　(3)　036501-036501　2020/03/01

    Publisher: IOP Publishing

    DOI： 10.35848/1882-0786/ab6fb1 　

    ISSN： 1882-0778

    eISSN： 1882-0786

  6. Raman and Infrared Research on Biological Tissues and Cells Peer-reviewed

    Shin-ichi MORITA

    Analytical Sciences (for review)　35　(5)　477-477　2019/05/10

    Publisher: Japan Society for Analytical Chemistry

    DOI： 10.2116/analsci.highlights1905 　

    ISSN： 0910-6340

    eISSN： 1348-2246

  7. バイオ・ラマン研究の現状とこれから Invited Peer-reviewed

    宮田大輔, 中林孝和, 盛田伸一

    レーザー研究　47　(2)　85-88　2019/02

  8. プラズモンとラマン顕微鏡による生体組織・単一生細胞・単一分子の分析化学 Invited

    盛田伸一, 伊藤民武

    化学工業　70　(4)　267-272　2019

  9. Generalized Two-dimensional Correlation Analysis for Unimodal Waveforms Modeled by Quadratic Polynomials Peer-reviewed

    Tatsuro SUGAWARA, Takakazu NAKABAYASHI, Shin-ichi MORITA

    Analytical Sciences　34　(7)　845-847　2018/07/10

    Publisher: Japan Society for Analytical Chemistry

    DOI： 10.2116/analsci.17n040 　

    ISSN： 0910-6340

    eISSN： 1348-2246

  10. A Proposal for Automated Background Removal of Bio-Raman Data Peer-reviewed

    Tatsuro SUGAWARA, Qi YANG, Takakazu NAKABAYASHI, Shin-ichi MORITA

    Analytical Sciences　33　(12)　1323-1325　2017

    Publisher: Japan Society for Analytical Chemistry

    DOI： 10.2116/analsci.33.1323 　

    ISSN： 0910-6340

    eISSN： 1348-2246

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    The subtraction of background components from observed spectra is essential in performing multivariable analysis, frequently applied to Raman spectra of cells. The subtraction procedure, however, is manual and time consuming, especially for big data. Here, we propose an automated method for removing background information from measured spectra of cells, exhibiting the theoretical framework and an experimental application.

  11. Raman Spectral Dynamics of Single Cells in the Early Stages of Growth Factor Stimulation Peer-reviewed

    Sota Takanezawa, Shin-ichi Morita, Yukihiro Ozaki, Yasushi Sako

    Biophysical Journal　108　(9)　2148-2157　2015/05

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2015.03.037 　

    ISSN： 0006-3495

  12. Raman and Autofluorescence Spectrum Dynamics along the HRG-Induced Differentiation Pathway of MCF-7 Cells Peer-reviewed

    Shin-ichi Morita, Sota Takanezawa, Michio Hiroshima, Toshiyuki Mitsui, Yukihiro Ozaki, Yasushi Sako

    Biophysical Journal　107　(10)　2221-2229　2014/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2014.10.002 　

    ISSN： 0006-3495

  13. Mechanism of sequential order determination in bio-Raman correlation analysis Peer-reviewed

    Sota Takanezawa, Yasushi Sako, Yukihiro Ozaki, Shin-ichi Morita

    Nano-Bio Sensing, Imaging, and Spectroscopy　2013/05/20

    Publisher: SPIE

    DOI： 10.1117/12.2018723 　

  14. Image enhancement of optical images for binary system of melanocytes and keratinocytes Peer-reviewed

    S. Takanezawa, A. Baba, Y. Sako, Y. Ozaki, A. Date, K. Toyama, S. Morita

    Nano-Bio Sensing, Imaging, and Spectroscopy　2013/05/20

    Publisher: SPIE

    DOI： 10.1117/12.2018681 　

  15. Raman imaging of the diverse states of the filamentous cyanobacteria Peer-reviewed

    J. Ishihara, M. Tachikawa, A. Mochizuki, Y. Sako, H. Iwasaki, S. Morita

    Nano-Bio Sensing, Imaging, and Spectroscopy　2013/05/20

    Publisher: SPIE

    DOI： 10.1117/12.2018694 　

  16. The Points in Bio-Raman Research Peer-reviewed

    Shin-ichi MORITA, Tamitake ITOH

    Seibutsu Butsuri　53　(1)　047-048　2013

    Publisher: Biophysical Society of Japan

    DOI： 10.2142/biophys.53.047 　

    ISSN： 0582-4052

    eISSN： 1347-4219

  17. Raman Spectroscopic Analysis of H2O2-Stimulated Three-Dimensional Human Skin Models Containing Asian, Black, and Caucasian Melanocytes Peer-reviewed

    Shin-ichi Morita, Sota Takanezawa, Akira Date, Shin Watanabe, Yasushi Sako

    Journal of Spectroscopy　2013　1-6　2013

    Publisher: Hindawi Limited

    DOI： 10.1155/2013/903450 　

    ISSN： 2314-4920

    eISSN： 2314-4939

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    Reactive oxygen species generated in dermal cells of human skin is related to skin disorders or diseases. In this study, Raman analysis effectively clarified the identities of three types of human skin models after the models were stimulated with hydrogen peroxide. With the Caucasian skin model, the major Raman bands underwent large intensity changes within 4-5 days of stimulation. With the Black skin model, the Raman bands remained almost unchanged. The changes in the Asian skin model were unique compared to those in the above two. Eumelanin and pheomelanin are probably the main compounds that differentiate dermal cells in terms of their sensitivity to hydrogen peroxide.

  18. Two-Dimensional Raman Correlation Analysis of Diseased Esophagus in a Rat Peer-reviewed

    Sota Takanezawa, Shin-ichi Morita, Atsushi Maruyama, Takurou N. Murakami, Norimichi Kawashima, Hiroyuki Endo, Katsunori Iijima, Tohru Asakura, Tooru Shimosegawa, Hidetoshi Sato

    Applied Physics Express　3　(7)　077001-077001　2010/07/09

    DOI： 10.1143/apex.3.077001 　

    ISSN： 1882-0778

    eISSN： 1882-0786

  19. Optical Characterization of a Hollow Fiber Raman Probe toward Non-Invasive Measurements of Living Tissues Peer-reviewed

    Hiroki Mitsuoka, Shin-ichi Morita, Toshiaki Suzuki, Yuji Matsuura, Yukiteru Katsumoto, Hidetoshi Sato

    Applied Physics Express　2　(2)　027001-027001　2009/01/30

    Publisher: IOP Publishing

    DOI： 10.1143/apex.2.027001 　

    ISSN： 1882-0778

    eISSN： 1882-0786

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    The use of a hollow fiber as a Raman probe, which gives strong advantage of a free link in space, was confirmed to be a versatile and standard analytical method, since Raman data obtained through a hollow fiber probe assures a sufficient link to conventional Raman data. In this paper, we confirmed that a Raman spectrum given by the hollow fiber probe becomes identical to a Raman spectrum measured by a conventional approach, if one is multiplied by an optimized coefficient. In addition, Raman signal intensity changes were related to various types of curved geometries of the probe. The Raman signal intensity value at a curved geometry of the probe, which is one of the most frequently used positions, became 0.35 compared to the value at the standard position of the probe (straight lined).

  20. Two-dimensional infrared correlation spectroscopy: Global phase angles for specific analytical systems Peer-reviewed

    Shin-ichi Morita, Saratchandra Shanmukh, Richard A. Dluhy

    Journal of Molecular Structure　799　(1-3)　48-51　2006/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.molstruc.2006.03.016 　

    ISSN： 0022-2860

  21. The application of two-dimensional correlation spectroscopy to surface and interfacial analysis Peer-reviewed

    Richard Dluhy, Saratchandra Shanmukh, Shin-Ichi Morita

    Surface and Interface Analysis　38　(11)　1481-1496　2006/11

    Publisher: Wiley

    DOI： 10.1002/sia.2358 　

    ISSN： 0142-2421

    eISSN： 1096-9918

  22. A General Model-Based Approach to Two-Dimensional Infrared Correlation Spectroscopy Incorporating the Global Phase Angle Peer-reviewed

    Shin-Ichi Morita, Saratchandra Shanmukh, Yukihiro Ozaki, Richard A. Dluhy

    Applied Spectroscopy　60　(11)　1279-1284　2006/11

    Publisher: SAGE Publications

    DOI： 10.1366/000370206778999058 　

    ISSN： 0003-7028

    eISSN： 1943-3530

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    We describe a theoretical framework for a model-based approach to two-dimensional correlation spectroscopy that is generally applicable to any arbitrary model function. The method is based on the correlation between spectral data and a set of model waveforms with a varying correlation index, the global phase angle Θ. When experimental spectral intensity variations are expressed as sinusoidal, exponential, Lorentzian, or quadratic functions, the proposed approach allows us to estimate the quantitative values of the target parameters in those expressions. In addition, this method enables us to assess the sequential order in a series of bands undergoing non-identical intensity changes in a dynamic data set. We present both simulated and experimentally obtained data that illustrate that the deviations from linearity of the absorption band intensity waveforms are clearly detected and can be quantitatively estimated using quadratic functions.

  23. Reorganization of Redshifted Band in Merocyanine–Cd Arachidate Mixed Langmuir–Blodgett Films Induced by Hydrothermal Treatments Peer-reviewed

    Syuji Mouri, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    Japanese Journal of Applied Physics　45　(10A)　7925-7927　2006/10/06

    Publisher: IOP Publishing

    DOI： 10.1143/jjap.45.7925 　

    ISSN： 0021-4922

    eISSN： 1347-4065

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    The effect of hydrothermal treatments (HTT) on merocyanine (MS)–Cd arachidate mixed Langmuir–Blodgett (LB) films has been studied. At temperatures ranging from 30 to 90 °C, the redshifted J-band in the as-deposited state has been found to reorganize under the condition of 100% relative humidity, forming a new phase of further redshifted bands with spectra sharper than those of the as-deposited J-band. The HTT-induced phase closely resembles that induced by the heat treatment without humidity control, while the occurrence of the latter is limited to 60–70 °C. The water content introduced into the LB system during HTT is suggested to play a catalytic role in facilitating the reorganization by its lubricating and/or hydrolyzing effects to soften the film structure.

  24. New correlation indices invariant to band shifts in generalized two-dimensional correlation infrared spectroscopy Peer-reviewed

    Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi, Yukihiro Ozaki

    Chemical Physics Letters　402　(1-3)　251-257　2005/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.cplett.2004.12.038 　

    ISSN： 0009-2614

  25. Global phase angle mapping method in the generalized two-dimensional correlation infrared spectroscopy for the band shifting and broadening phenomena Peer-reviewed

    Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi, Yukihiro Ozaki

    Vibrational Spectroscopy　36　(2)　271-278　2004/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.vibspec.2004.01.007 　

    ISSN： 0924-2031

  26. Premelting Behavior of a Langmuir−Blodgett Film of Dioctadecyldimethylammonium-Au(dmit)2Salt Peer-reviewed

    Shin-ichi Morita, Akifumi Ikehata, Yasuhiro F. Miura, Michio Sugi, Yukihiro Ozaki

    The Journal of Physical Chemistry B　108　(50)　19354-19360　2004/12

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/jp040403b 　

    ISSN： 1520-6106

    eISSN： 1520-5207

  27. Thermal behavior of a Langmuir-Blodgett film of dioctadecyldimethylammonium-Au(dmit)2 salt investigated by infrared spectroscopy Peer-reviewed

    Shin-ichi Morita, Akifumi Ikehata, Yasuhiro F. Miura, Michio Sugi, Yukihiro Ozaki

    Thin Solid Films　464-465　408-411　2004/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.tsf.2004.06.019 　

    ISSN： 0040-6090

  28. Infrared and Ultraviolet−Visible Spectroscopic Studies on Premelting Behavior of One- and Eleven-Layer Langmuir−Blodgett Films of 2-Dodecyl-, 2-Pentadecyl-, and 2-Octadecyl-7,7,8,8-tetracyanoquinodimethane Peer-reviewed

    Shin-ichi Morita, Katsuhiro Nichogi, Yukihiro Ozaki

    The Journal of Physical Chemistry B　108　(23)　7871-7877　2004/06

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/jp037797b 　

    ISSN： 1520-6106

    eISSN： 1520-5207

  29. Infrared spectroscopic study on the Langmuir–Blodgett films of merocyanine dye–arachidic acid–n-octadecane ternary system Peer-reviewed

    Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi, Yoshiaki Hirano

    Journal of Applied Physics　94　(7)　4368-4373　2003/10

    Publisher: AIP Publishing

    DOI： 10.1063/1.1606516 　

    ISSN： 0021-8979

    eISSN： 1089-7550

  30. Pattern Recognitions of Band Shifting, Overlapping, and Broadening Using Global Phase Description Derived from Generalized Two-Dimensional Correlation Spectroscopy Peer-reviewed

    Shin-Ichi Morita, Yukihiro Ozaki

    Applied Spectroscopy　56　(4)　502-508　2002/04

    Publisher: SAGE Publications

    DOI： 10.1366/0003702021954953 　

    ISSN： 0003-7028

    eISSN： 1943-3530

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    In this paper we propose a new method for pattern recognitions of band shifting, overlapping, and broadening using a global phase map derived from generalized two-dimensional correlation spectroscopy (global 2D phase map). To obtain the distinct patterns for band shifting, overlapping, and broadening, original spectra are subjected to scaling so that the spectra after the scaling do not cross one another. After such pretreatment the band shifting creates the tilting of a correlation plane, the band overlapping yields four flat terraces, and the band broadening generates an asymmetric curved plane with respect to the diagonal line in the global 2D phase map. An example of the application of this method has been investigated using two bands due to the CH2 symmetric stretching and CN stretching vibrations in temperature-dependent infrared (IR) transmission spectra of an eleven-layer Langmuir–Blodgett (LB) film of 2-dodecyl-7,7,8,8-tetracyanoquinodimethane (dodecyl-TCNQ). The global 2D phase maps develop the clearly distinct patterns due to the shifting, overlapping, and broadening even if the shifting and broadening bands are overlapped with other bands.

  31. Global Phase Angle Description of Generalized Two-Dimensional Correlation Spectroscopy: 2. Its Application to Temperature-Dependent Infrared Spectra of a Langmuir—Blodgett Film of 2-Dodecyl-7,7,8,8-Tetracyanoquinodimethane Peer-reviewed

    Shin-Ichi Morita, Yukihiro Ozaki, Isao Noda

    Applied Spectroscopy　55　(12)　1622-1627　2001/12

    Publisher: SAGE Publications

    DOI： 10.1366/0003702011954198 　

    ISSN： 0003-7028

    eISSN： 1943-3530

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    A spectral analysis based on the concept of a global phase map derived from generalized two-dimensional (2D) synchronous and asynchronous correlation spectra has been applied to actual experimental data to demonstrate its potential. As an application of a global 2D phase map, temperature-dependent infrared transmission spectra from 30 to 80 °C of an eleven-layer Langmuir–Blodgett (LB) film of 2-dodecyl-7,7,8,8-tetracyanoquinodimethane (dodecyl-TCNQ) have been investigated. Although the generalized 2D correlation asynchronous map presents only a very weak signal due to the CH3 asymmetric stretching vibration compared with much stronger signals due to the CH2 stretching vibrations of dodecyl-TCNQ, the global 2D phase map clearly shows the distinct nonlinear response arising from the CH3 asymmetric stretching vibration. The detection of nonlinear responses suggests that the active thermal movement of the alkyl-chain loses a trans-zigzag skeleton plane in the intermediate state above 80 °C between the solid and melt states.

  32. Global Phase Angle Description of Generalized Two-Dimensional Correlation Spectroscopy: 1. Theory and its Simulation for Practical Use Peer-reviewed

    Shin-Ichi Morita, Yukihiro Ozaki, Isao Noda

    Applied Spectroscopy　55　(12)　1618-1621　2001/12

    Publisher: SAGE Publications

    DOI： 10.1366/0003702011954189 　

    ISSN： 0003-7028

    eISSN： 1943-3530

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    The concept of a global phase map derived from generalized two-dimensional synchronous and asynchronous correlation spectra is introduced to extract the purely correlational information by intentionally canceling amplitude information. For the practical usage of a global 2D phase map, a filtering method based on the standard deviation spectrum obtained from the time series intensity profiles is proposed to remove the effect of small amplitude noise. A simulation created with the use of three synthesized bands with exponential decay has clearly detected the only difference in the characteristic rate constant of the decay process in the global 2D phase map, although the three bands have different initial values of the peak intensity amplitudes.

  33. Aging Effects on Molecular Orientation, Structure, and Morphology in Langmuir−Blodgett Films of 2-Dodecyl-, 2-Pentadecyl-, and 2-Octadecyl-7,7,8,8-tetracyanoquinodimethane Studied by Infrared and Ultraviolet−Visible Spectroscopy and Atomic Force Microscopy Peer-reviewed

    Shin-ichi Morita, Keiji Iriyama, Yukihiro Ozaki

    The Journal of Physical Chemistry B　104　(6)　1183-1190　2000/02/01

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/jp992988t 　

    ISSN： 1520-6106

    eISSN： 1520-5207

  34. Thermal Behavior of One-Layer Langmuir-Blodgett Films of 2-Pentadecyl-7,7,8,8-Tetracyanoquinodimethane Studied by Ultraviolet-Visible and Infrared Spectroscopies Peer-reviewed

    Shin-Ichi Morita, Katsuhiro Nichogi, Yukihiro Ozaki

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals　337　(1)　325-328　1999/11

    Publisher: Informa UK Limited

    DOI： 10.1080/10587259908023443 　

    ISSN： 1058-725X

  35. IR and AFM Studies on Aging Effects of One-layer Langmuir-Blodgett Films of 2-Alkyl-7,7,8,8-tetracyanoquinodimethane Peer-reviewed

    Shinichi Morita, Haishui Wang, Yan Wang, Keiji Iriyama, Yukihiro Ozaki

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals　322　(1)　215-220　1998/11

    Publisher: Informa UK Limited

    DOI： 10.1080/10587259808030226 　

    ISSN： 1058-725X

  36. Visualization of the sequence of changes in the full wavenumber range by two-dimensional correlation spectroscopy

    Kazunori Ban, Daisuke Miyata, Yoshiteru Matsumoto, Shinya Tahara, Hiroaki Takahashi, Shin-ichi Morita, Takakazu Nakabayashi

    Chemical Physics Letters　140930-140930　2023/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.cplett.2023.140930 　

    ISSN： 0009-2614

  37. Development of Highly Conductive Langmuir-Blodgett Films Peer-reviewed

    Yasuhiro F. Miura, Masaaki Kitao, Haruki Matsui, Ryo Watanabe, Shin-ichi Morita

    Transactions of the Materials Research Society of Japan　37　(2)　107-110　2012

    Publisher: The Materials Research Society of Japan

    DOI： 10.14723/tmrsj.37.107 　

    ISSN： 1382-3469

    eISSN： 2188-1650

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    Studies on highly conductive LB films based on ditetradecyldimethylammonium-Au(dmit)2 [2C14-Au(dmit)2] salt have been reviewed. The room temperature conductivity of the 2C14-Au(dmit)2 LB film is as high as 40 S/cm after electro-oxidation. The resistance vs. temperature plot depends on the gap distance for the measurement. A weak metallic behavior is seen from room temperature down to 210-250 K, when the gap distance is 500 μm, while it extends down to 56-106 K, when the gap distance is 5 μm, indicating that the disorders in the film are important limiting factors for the macroscopic resistance. The data of the complex magnetic susceptibility (χ' + iχ") suggest the existence of the Meissner state below 3.9 K. Although some samples show resistance drop on cooling below 4 K, the typical resistance behaviors are of activation type at the lower temperature. We consider that disorders such as grain boundaries and/or defects are important limiting factors that should be solved to improve the electrical conduction toward the realization of global superconductivity.

  38. Raman imaging analysis of pharmaceutical tablets by two-dimensional (2D) correlation spectroscopy Peer-reviewed

    Hideyuki Shinzawa, Kimie Awa, Takehiro Okumura, Shin-ichi Morita, Makoto Otsuka, Yukihiro Ozaki, Hidetoshi Sato

    Vibrational Spectroscopy　51　(1)　125-131　2009/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.vibspec.2008.11.011 　

    ISSN： 0924-2031

  39. Multiple Perturbation Two-Dimensional Correlation Analysis of Cellulose by Attenuated Total Reflection Infrared Spectroscopy Peer-reviewed

    Hideyuki Shinzawa, Shin-Ichi Morita, Kimie Awa, Mariko Okada, Isao Noda, Yukihiro Ozaki, Hidetoshi Sato

    Applied Spectroscopy　63　(5)　501-506　2009/05

    Publisher: SAGE Publications

    DOI： 10.1366/000370209788346977 　

    ISSN： 0003-7028

    eISSN： 1943-3530

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    An extension of the two-dimensional (2D) correlation analysis scheme for multi-dimensional perturbation is described. A simple computational form is provided to construct synchronous correlation and disrelation maps for the analysis of microscopic imaging data based on two independent perturbation variables. Sets of time-dependent attenuated total reflection infrared (ATR-IR) spectra of water and cellulose mixtures were collected during the evaporation of water from finely ground cellulose. The system exhibits complex behaviors in response to two independent perturbations, i.e., evaporation time and grinding time. Multiple perturbation 2D analysis reveals a specific difference in the rate of evaporation of water molecules when accompanied by crystallinity changes of cellulose. It identifies subtle differences in the volatility of water, which is related to the crystalline structure of cellulose.

  40. An optical biopsy system with miniaturized Raman and spectral imaging probes; in vivo animal and ex vivo clinical application studies Peer-reviewed

    Hidetoshi Sato, Toshiaki Suzuki, Bibin B. Andriana, Shin'ichi Morita, Atsushi Maruyama, Hideyuki Shinzawa, Yuichi Komachi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Yuji Matsuura, Masakazu Toi, Toru Shimosegawa, Yukihiro Ozaki

    Advanced Biomedical and Clinical Diagnostic Systems VII　2009/02/12

    Publisher: SPIE

    DOI： 10.1117/12.809271 　

  41. Endoscopic observation of N-Methyl-N'-Nitro-Nnitrosoguanidine-induced gastric carcinogenesis in rat using a newly-developed flexible endoscope Peer-reviewed

    Shinya Kondo, Takeshi Toyoda, Atsushi Maruyama, Shinichi Morita, Hidetoshi Sato, Yuichi Komachi, Genichi Kanai, Takafumi Ando, Hidemi Goto, Masae Tatematsu, Tetsuya Tsukamoto

    Asian Pacific Journal of Cancer Prevention　10　(5)　883-886　2009

  42. 数理的スペクトル解析法による製剤のラマンイメージング解析

    新澤 英之, 阿波 君枝, 盛田 伸一, 奥村 剛弘, 尾崎 幸洋, 佐藤 英俊

    日本分析化学会講演要旨集　57年会　43-43　2008/08

    Publisher: (公社)日本分析化学会

  43. Giant domain formation in Langmuir-Blodgett films based on Alkylammonium-Au(dmit)(2) salt Peer-reviewed

    Y. F. Miura, K. Hayashi, M. Kitao, M. Takagi, H. Matsui, M. Sugi

    THIN SOLID FILMS　516　(9)　2518-2521　2008/03

    DOI： 10.1016/j.tsf.2007.04.137 　

    ISSN： 0040-6090

  44. Application study of the optical biopsy system for small experimental animals Peer-reviewed

    Hidetoshi Sato, Toshiaki Suzuki, Shin-ichi Morita, Atsushi Maruyama, Toru Shimosegawa, Yuji Matsuura, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Yukihiro Ozaki

    Biomedical Optical Spectroscopy　2008/02/07

    Publisher: SPIE

    DOI： 10.1117/12.764729 　

  45. Chapter 12 Monolayers on Air/Solid Interfaces: Vibrational Spectroscopy and Atomic Force Microscopy Studies Peer-reviewed

    Yukihiro Ozaki, Shin-ichi Morita, Yoshiaki Hirano, Xiaoling Li

    Interface Science and Technology　309-359　2007

    Publisher: Elsevier

    DOI： 10.1016/s1573-4285(06)14012-0 　

    ISSN： 1573-4285

  46. Thermally induced J-band narrowing in merocyanine LB films Peer-reviewed

    Junpei Miyata, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    Colloids and Surfaces A: Physicochemical and Engineering Aspects　284-285　509-513　2006/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.colsurfa.2005.10.056 　

    ISSN： 0927-7757

  47. Methodology for fabricating LB films of fullerene Peer-reviewed

    Yasuhiro F. Miura, Mitsutaka Urushibata, Issei Matsuoka, Shin-ichi Morita, Michio Sugi

    Colloids and Surfaces A: Physicochemical and Engineering Aspects　284-285　93-96　2006/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.colsurfa.2005.11.036 　

    ISSN： 0927-7757

  48. Structure and Properties of Highly Conductive Langmuir–Blodgett Films Based on Dioctyldimethylammonium–Au(dmit)2Salt Peer-reviewed

    Yuuki Takigawa, Ryo Watanabe, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    Japanese Journal of Applied Physics　45　(1B)　394-396　2006/01/20

    Publisher: IOP Publishing

    DOI： 10.1143/jjap.45.394 　

    ISSN： 0021-4922

    eISSN： 1347-4065

    More details Close

    Langmuir–Blodgett (LB) films of dioctyldimethylammonium–Au(dmit)2 [2C8–Au(dmit)2] salt show a relatively high room-temperature conductivity of up to 17 S/cm. The conductivity is as high as $50 \pm 23$ S/cm after electrochemical oxidation. A distinct absorption band is seen at 287 nm and it increases linearly with the number of layers, indicating a reproducible film deposition for up to 20 layers. During the post-treatment, the absorption peak decreases together with some shoulders and a broad band appears in the near-infrared (NIR) region with an isosbestic point at 609 nm, indicating the formation of conduction electrons. The UV/visible absorption spectrum changes markedly in the first 60 min of the post-treatment and becomes almost constant later, which corresponds well with the change in conductivity during the post-treatment.

  49. Electrical properties of the dialkyldimethylammomium-Au(dmit)(2) LB films Peer-reviewed

    Masaaki Kitao, Hawki Matsui, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi, Masato Hedo, Yoshiya Uwatoko

    Transactions of the Materials Research Society of Japan, Vol 31, No 3　31　(3)　621-624　2006

  50. Infrared spectroscopic study on the alkylammonium-Au(dmit)(2) LB films Peer-reviewed

    Haruki Matsui, Ryo Watanabe, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    TRANSACTIONS OF THE MATERIALS RESEARCH SOCIETY OF JAPAN, VOL 31, NO 3　31　(3)　617-619　2006

  51. Highly-conductive LB films of dioctyldimehylammonium-Au(dmit)(2) salt Peer-reviewed

    Masato Takagi, Yuuki Takigawa, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    TRANSACTIONS OF THE MATERIALS RESEARCH SOCIETY OF JAPAN, VOL 31, NO 3　31　(3)　613-615　2006

  52. Fabrication of C60 Films by Horizontal Lifting Method Peer-reviewed

    A. Yamashita, S. Morita, I. Matsuoka, Y.F. Miura, M. Sugi

    Trans. Mater. Res. Soc. Jpn.　31　(3)　609-612　2006

  53. Control of J-aggregates in the MS-containing LB Films by Heat Treatments Peer-reviewed

    S. Mouri, J. Miyata, S. Morita, Y.F. Miura, M. Sugi

    Transactions of the Materials Research Society of Japan　31　(3)　573-576　2006

  54. Thermally induced reorganization of redshifted band in merocyanine-Cd arachidate mixed Langmuir-Blodgett films Peer-reviewed

    J Miyata, S Morita, YF Miura, M Sugi

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS　44　(11)　8110-8112　2005/11

    DOI： 10.1143/JJAP.44.8110 　

    ISSN： 0021-4922

  55. 二次元相関分光法の新展開

    盛田伸一, 尾崎幸洋

    表面　43　(6)　279-286　2005

    Publisher: 広信社

    ISSN： 0367-648X

  56. Infrared Spectroscopic Study on LB films based on Ditetradecyldimethylammonium-Au(dmit)2 Salt Peer-reviewed

    R. Watanabe, S. Morita, Y. F. Miura, M. Sugi

    Trans. Mater. Res. Soc. Jpn.　30　(1)　135-138　2005

  57. 高導電性ラングミュア・ブロジェット膜の構造と物性

    三浦康弘, 渡邊 亮, 盛田伸一, 杉 道夫

    表面　42　(9)　276-288　2004

    Publisher: 広信社

    ISSN： 0367-648X

  58. Infrared spectroscopic study on the dye containing LB films Peer-reviewed

    Yoshiaki Hirano, Shin-ichi Morita, Yasuhiro F. Miura, Michio Sugi

    Thin Solid Films　438-439　225-229　2003/08

    Publisher: Elsevier BV

    DOI： 10.1016/s0040-6090(03)00776-4 　

    ISSN： 0040-6090

  59. Structural Characterization of Langmuir-Blodgett Films of the Dioctadecyldimethylammonium-Au(dmit)2 Salt Studied by Infrared Spectroscopy and Atomic Force Microscopy Peer-reviewed

    S. Morita, Y. F. Miura, K. Ikegami, M. Sugi

    Trans. Mater. Res. Soc. Jpn.　28　(1)　27-30　2003

  60. The Structure of the Dye Containing LB films Investigated by Infrared Spectroscopy Peer-reviewed

    Y. Hirano, S. Morita, Y. F. Miura, M. Sugi

    Trans. Mater. Res. Soc. Jpn.　28　(1)　55-58　2003

  61. PRESSURE EFFECT ON CONDUCTIVITY IN Au(dmit)2 LANGMUIR–BLODGETT FILMS Peer-reviewed

    YASUHIRO F. MIURA, SHIN-ICHI MORITA, SHIN-HACHIRO SAITO, MICHIO SUGI, MASATO HEDO, YOSHIYA UWATOKO

    International Journal of Nanoscience　01　(05n06)　627-630　2002/10

    DOI： 10.1142/s0219581x02000784 　

    ISSN： 0219-581X

    eISSN： 1793-5350

  62. 二次元相関分光法

    尾崎幸洋, 勝本之晶, 盛田伸一

    ぶんせき　(7)　417　2001

  63. root omega-variation of AC admittance in the inhomogeneously distributed RC lines Peer-reviewed

    M Sugi, Y Hirano, YF Miura, K Saito

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS　39　(9A)　5367-5368　2000/09

    DOI： 10.1143/JJAP.39.5367 　

    ISSN： 0021-4922

  64. Thermal Stability of 1-Layer LB Film of Trichloro(Octadecyl)Silane Peer-reviewed

    Ken-Ichi Iimura, Teiji Kato, Shin-Ichi Morita, Yukihiro Ozaki

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals　337　(1)　113-116　1999/11

    Publisher: Informa UK Limited

    DOI： 10.1080/10587259908023390 　

    ISSN： 1058-725X

  65. Studies on Control of Molecular Re-Arrangement in Langmuir-Blodgett Films of 2-Pentadecyl-7,7,8,8-Tetracyanoquinodimethane by Infrared and Ultraviolet-Visible Spectroscopy Peer-reviewed

    Hai-Shui Wang, Shin-Ichi Morita, Keiji Iriyama, Yukihiro Ozaki

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals　337　(1)　321-324　1999/11

    Publisher: Informa UK Limited

    DOI： 10.1080/10587259908023442 　

    ISSN： 1058-725X

  66. Raman Study of Mixed-Stack Charge Transfer Films of 2-Octadecyl-7,7,8,8-Tetracyanoquinodimethane and 3,3′,5,5′-Tetramethylbenzidine Prepared by the Langmuir-Blodgett Technique and Donor Doping Peer-reviewed

    Young Mee Jung, Shin-Ichi Morita, Masanobu Ogane, Teruki Ikeda, Hideo Tashiro, Yukihiro Ozaki

    Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals　327　(1)　225-228　1999/02

    Publisher: Informa UK Limited

    DOI： 10.1080/10587259908026819 　

    ISSN： 1058-725X

  67. Blue-shifted band in LB films of merocyanic-arachidic acid-N-alkane ternary system Peer-reviewed

    Y Hirano, JI Kawata, YF Miura, M Sugi, T Ishii

    MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS　337　(1)　337-340　1999

    DOI： 10.1080/10587259908023446 　

    ISSN： 1058-725X

  68. Conductive Langmuir-Blodgett films based on dialkyldimethylammonium-metal(dmit)(2) Peer-reviewed

    YF Miura, Y Kurashige, Y Hirano, J Kawata, M Sugi

    THIN SOLID FILMS　327　(1)　443-445　1998/08

    DOI： 10.1016/S0040-6090(98)00682-8 　

    ISSN： 0040-6090

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Misc. 3

  1. 赤外分光法による2C18-Au(dmit)2LB膜の熱挙動の研究

    盛田伸一, 渡辺亮, 佐藤慶祐, 池羽田晶文, 三浦康弘, 杉道夫, 尾崎幸洋

    応用物理学関係連合講演会講演予稿集　51st　(3)　2004

  2. 赤外分光法による導電性LB膜の熱挙動に関する研究

    盛田伸一, 渡辺亮, 池羽田晶文, 三浦康弘, 杉道夫, 尾崎幸洋

    分子構造総合討論会講演要旨集(CD-ROM)　2003　2003

  3. Structure of LB films studied by the global phase angle description derived from generalized two-dimensional correlation spectroscopy

    Morita Shin-ichi, Miura Yasuhiro F., Sugi Michio, Ozaki Yukihiro

    Meeting abstracts of the Physical Society of Japan　57　(2)　693-693　2002/08/13

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

Presentations 16

  1. The Points in Bio-Raman Research Invited

    Shin-ichi Morita

    Department Colloquium，National Chiao Tung University　2013/03

  2. 最近のバイオラマン研究について Invited

    盛田伸一

    大学院セミナー，桐蔭横浜大学　2013/02

  3. 皮膚色素沈着とバイオラマン分析について Invited

    盛田伸一

    教育招待講演，神戸P&G テクニカルセンター　2012/12

  4. 最先端光計測の近未来－生細胞ダイナミクスのラマン計測および数理解析－ Invited

    盛田伸一

    大学院セミナー，桐蔭横浜大学　2012/02

  5. Raman spectroscopy for non-invasive microscopic analysis of biological systems and single live cells Invited

    Shin-ichi Moritta

    招待講演，日本生物物理学会，仙台　2010/09

  6. Quantitative Estimations in 2D IR Correlation Spectroscopy Invited

    S. Morita, H. Sato

    The Fourth International Symposium on Two-Dimensional Correlation Spectroscopy (2DCOS-2007), Beijing, China　2007/08

  7. Global Phase Angles for Specific Analytical Systems in Generalized Two-Dimensional Correlation Spectroscopy Invited

    S. Morita, Y. Zhu, S. Shanmukh, R.A. Dluhy

    The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Florida, U.S.　2006/09

  8. 赤外スペクトルを二次元的に展開するアプローチを用いた機能性LB膜の構造解析 Invited

    盛田伸一, 三浦康弘, 杉 道夫, 尾崎幸洋

    第16回日本MRS学術シンポジウム，日本大，東京　2005/12

  9. Generalized Two-dimensional Correlation Spectroscopy Invariant to Band Shifts Invited

    S. Morita, Y.F. Miura, M. Sugi, Y. Ozaki

    Third International Symposium on Two-Dimensional Correlation Spectroscopy (2DCOS-3), Wisconsin, U.S.　2005/08

  10. Introduction of New Correlation Indices Independent of the Band Shifting and Broadening Phenomena in Generalized Two-Dimensional Correlation Infrared Spectroscopy Invited

    S. Morita, Y.F. Miura, M. Sugi, Y. Ozaki

    The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), Portland, Oregon, U.S.　2004/10

  11. 新しい二次元相関分光法を用いた機能性有機薄膜の構造解析 Invited

    盛田伸一, 三浦康弘, 杉 道夫, 尾崎幸洋

    JOEM-M&BE共催研究会「分子薄膜材料の電子輸送及び配向解析の新手法」, 東京, 機会振興会館　2004/10

  12. Global Phase Angle for Generalized Two-Dimensional Correlation Infrared Spectroscopy Invited

    S. Morita, Y.F. Miura, M. Sugi, Y. Ozaki

    ”, Second International Symposium on Two-Dimensional Correlation Spectroscopy (2DCOS-2), Nottingham, U.K.　2003/08

  13. 位相角表示一般化二次元相関分光法に関して Invited

    S. Morita, Y.F. Miura, M. Sugi, Y. Ozaki

    二次元相関分光法に関する国際ミニシンポジウム, 関西学院大　2003/03

  14. A Phase Angle Description of Generalized Two-dimensional Correlation Spectroscopy: Theory and Its Application Invited

    S. Morita, I. Noda, Y. Ozaki

    International Symposium on Spectral Analysis Methods in Vibrational Spectroscopy (ISSAM-VS), Kwansei Gakuin University　2000/07

  15. バイオラマン研究の実際 Invited

    盛田伸一

    依頼講演，（株）日本分光，八王子　2012/10

  16. バイオラマン研究の効きどころ Invited

    盛田伸一

    セミナー，兵庫スプリング8　2012/02

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Research Projects 13

  1. 刺激応答型ドラッグデリバリーの実現およびバイオ・ラマン顕微鏡による分析

    盛田 伸一, BAHADUR ALI

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2022/04/22 - 2024/03/31

  2. 刺激応答型ドラッグデリバリーの実現およびバイオ・ラマン顕微鏡による分析

    盛田 伸一, BAHADUR ALI

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2021/11/18 - 2024/03/31

  3. 刺激応答型ドラッグデリバリーの実現およびバイオ・ラマン顕微鏡による分析

    盛田 伸一, BAHADUR ALI

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2021/09/28 - 2024/03/31

  4. 刺激応答型ドラッグデリバリーの実現およびバイオ・ラマン顕微鏡による分析

    盛田 伸一, BAHADUR ALI

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 特別研究員奨励費

    Institution: 東北大学

    2021/07/28 - 2024/03/31

  5. 刺激応答型ドラッグデリバリーの実現およびバイオ・ラマン顕微鏡による分析

    盛田 伸一, BAHADUR ALI

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東北大学

    2021/04 - 2023/03

  6. バイオ分析化学の推進

    Offer Organization: 東京インスツルメンツ社

    System: 寄附金

    2019 - 2023

  7. バイオ分析化学の推進（毛髪のラマン計測と解析）

    Offer Organization: ミルボン社

    System: 寄附金

    2017 - 2021

  8. Development of a Bio-Raman Microscope to Enable Long Term Monitoring of Single Cells

    Shin-ichi Morita

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04 - 2018/03

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    Recently it became possible to measure Raman spectra of a single live cell using a standard Raman microscope. We developed a bio-Raman microscope in order to monitor the dynamics of cellular differentiation, proliferation, and apoptosis. To do so, living cells were incubated on the microscope stage. Using the bio-Raman microscope, we defined cellular states in a non-destructive and non-labeling manner. The obtained information of cellular conditions is very important to control cellular destinies aiming tissue engineering. Advanced mathematical methods, developed in this project, were found effective to spectral analysis in a general manner.

  9. マッチングファンド研究支援事業（2017年度）

    Offer Organization: 東北大学－産総研

    2017 - 2018

  10. Offer Organization: 東北大学 学際科学フロンティア研究所

    System: 領域創成研究 (2015年度－2016年度)

    2015 - 2017

  11. Raman spectrum analysis of cell differentiation dynamics

    SAKO Yasushi, MORITA Shinichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: The Institute of Physical and Chemical Research

    2011 - 2012

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    A human breast cancer cell line, MCF-7 differentiates into mammalian grand-like cells upon addition of heregulin to the culture medium. In this study, we traced changes of cellular internal states by means of Raman spectrum measurement, which is a potent method to detect multi-dimensional intracellular dynamics in single cells with minimal disruption. Analysis of the Raman dynamics up to 12 days though the differentiation process has revealed pseud-circular trajectory of the major intracellular components.

  12. 「肺サーファクタントの振動分光学」について

    Offer Organization: 理化学研究所

    System: 基礎科学特別研究員制度、研究推進費

    2008 - 2011

  13. 赤外分光及び原子間力顕微鏡法による導電性有機超薄膜の構造と機能の研究

    盛田 伸一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 桐蔭横浜大学

    2002 - 2004

    More details Close

    研究代表者の研究目的は、ジテトラデシルジメチルアンモニウム-Au(dmit)_2塩(2C_<14>-Au(dmit)_2塩)に基づくLangmuir-Blodgett(LB)膜の構造に関する情報を主に赤外分光法を用いて抽出し、LB膜が導電相、超伝導相を実現するメカニズムを明らかにすることであった。赤外スペクトルを解析するために、研究代表者が提案した位相角表示一般化二次元相関法を実験系に適用した。平成16年度の研究成果は、以下に要約される。 (1)これまで、LB膜の電気伝導度等の機能測定を継続的に行ってきた。今年度も引き続き、これを行った。低温領域の電気物性についても研究した。 (2)既に作製した温度変化赤外スペクトル測定システムを用いて、LB膜を温度変化させた時の赤外スペクトルを測定し、その構造変化について詳しく研究した。構造に関する情報に基づいて、LB膜に温度処理を施し、その導電性の向上に取り組んだ。 (3)申請者が提案した位相角表示一般化二次元相関分光法の理論体系の整理を行い、拡張した。具体的には、バンドシフト、ブロードニング問題を解決した。拡張した位相角法を実験データに適用した。 (4)研究成果をまとめ、その内容を権威ある雑誌に掲載した(J.Phys.Chem.BとChem.Phys.Lett.に1報ずつ掲載。)研究成果を国内外の学会で報告した。例えば、米国内の分析化学、分光関連学会(The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS))において、招待講演を行うなどした。

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