TOHOKU UNIVERSITY Researchers

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Yasuyuki Taki

Section

Smart-Aging Research Center

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/ytaki

J-GLOBAL ID

200901004444691216

Research History 4

2023/04 - Present

東北大学スマート・エイジング学際重点研究センター　センター長
2017/04 - Present

東北大学スマート・エイジング学際重点研究センター　副センター長
2013 - Present

Tohoku University　Institute of Development, Aging and Cancer
2012 - Present

東北大学東北メディカル・メガバンク機構　教授

Research Interests 30

脳発達
gray matter ratio
画像診断
MRI
灰白質
生活習慣
核磁気共鳴画像(MRI)
画像解析
脳・神経
遺伝子
放射線
脳
脳萎縮
認知機能
子供脳
睡眠習慣
海馬
地域コミュニティ支援
統合失調症
性差
東日本大震災
園芸療法
グラフ情報理論
被災者
脳形態計測
左前帯状皮質膝下野
脳加齢
生活介入
被災地
精神医学

Research Areas 7

Life sciences / Radiology /
Humanities & social sciences / Clinical psychology /
Life sciences / Psychiatry /
Life sciences / Basic brain sciences /
Life sciences / Hygiene and public health (non-laboratory) /
Life sciences / Hygiene and public health (laboratory) /
Life sciences / Healthcare management, medical sociology /

Awards 4

第42回日本医学放射線学会秋季臨床大会学会賞銅賞

2006/10　日本医学放射線学会
臨床放射線論文賞

2006/04　臨床放射線編集委員会
第40回日本医学放射線学会秋季臨床大会優秀展示賞

2004/11　日本医学放射線学会
日本神経回路学会論文賞

2004/09　日本神経回路学会

Papers 393

Localized pulmonary vascular changes in a mouse model of subarachnoid hemorrhage created by combining filament perforation and blood injection. International-journal

Ryota Tochinai, Takaya Suzuki, Kenji Tomita, Shin-Ichi Sekizawa, Yoshinori Okada, Yasuyuki Taki, Masayoshi Kuwahara, Tatsushi Mutoh

Microvascular research　160　104810-104810　2025/04/13

DOI： 10.1016/j.mvr.2025.104810 　

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INTRODUCTION: Subarachnoid hemorrhage (SAH) results in neurogenic pulmonary edema (NPE), a condition with a high mortality rate arising from increased hydrostatic pressure and vascular permeability. Two possible mechanisms of NPE are increased hydrostatic pressure and increased vascular permeability, and it is possible that increased permeability of capillaries in the lungs may contribute to the exacerbation of NPE. Recent research has highlighted the importance of the glycocalyx, a gel-like layer that lines blood vessels, in regulating vascular permeability in various diseases. However, its role in NPE after SAH has not been previously explored. This study investigated the involvement of the glycocalyx in the development of NPE by developing a mouse model of SAH. METHODS: The SAH model was developed by combining internal carotid artery (ICA) perforation and blood infusion into the cisterna magna of mice. The histological structure of the lungs was confirmed using micro-CT, histopathological examination, and scanning electron microscopy. RESULTS: Despite no obvious micro-CT findings indicating pulmonary edema, histopathological changes in hematoxylin and eosin-stained lung were detected. Scanning electron microscopy revealed glycocalyx exfoliation within the pulmonary microvascular wall. A trend toward higher plasma syndecan-1 levels was also observed. CONCLUSION: The combination of ICA perforation and blood infusion into the cisterna magna can produce pulmonary findings in mice that mimic NPE after SAH. The results also suggest that glycocalyx loss is involved in the development of NPE after SAH.
Beneficial Effects of a 26-Week Exercise Intervention Using IoT Devices on Cognitive Function and Health Indicators

Keishi Soga, Akira Higuchi, Naoki Tomita, Koki Kobayashi, Hiroki Kataoka, Aizhan Imankulova, Carlos Salazar, Benjamin Thyreau, Shota Nakamura, Yuki Tsushita, Akiyoshi Uchiyama, Yasuyuki Taki

Journal of Science in Sport and Exercise　2025/01/20
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s42978-024-00321-9 　

ISSN： 2096-6709

eISSN： 2662-1371

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Abstract Purpose This study examines the impact of 26-week exercise intervention facilitated by IoT devices on cognitive function, hippocampal volume, and health indicators in a real-world setting based on the Transtheoretical Model. Methods Middle-aged participants (n = 121, mean age = 49.8 ± 7.62 years) were randomly assigned to BrainUp (n = 61) or Sham (n = 60) application groups. Both groups engaged in voluntary aerobic exercise over a period of 26 weeks using an IoT device. The BrainUp application was designed to deliver personalized exercise routines aimed at enhancing participants’ cognitive function and hippocampal volume based on their individual level. Results Linear mixed models revealed that both groups exhibited improvements in cognitive function and health indicators at post-intervention compared to pre-intervention, but no significant changes in hippocampal volume in either group over time. Path analysis and structural equation modeling indicated that motivation for exercise at 26 weeks played a key role in improving cognitive function and blood glucose, and alleviating depression. Conclusions Integrating physical activity with IoT devices in real-world settings shows promise for enhancing brain health and preventing hippocampal volume loss due to aging. Motivation might play a crucial role in maximizing the health benefits of physical activity, especially during the transition from the Action to Maintenance stages of behavioral changes to an active lifestyle.
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia. International-journal

Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono

NPJ science of food　9　(1)　2-2　2025/01/07

DOI： 10.1038/s41538-024-00364-w 　

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This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas brain magnetic resonance imaging was performed to assess cerebral white matter lesions, hippocampal volume, and total brain volume. Multivariable-adjusted analysis revealed significant correlations between fewer cerebral white matter lesions and higher green tea consumption, whereas no significant differences were found between green tea consumption and hippocampal or total brain volume. Regarding coffee consumption, no significant differences were observed in cerebral white matter lesions or hippocampal or total brain volumes. Hence, higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.
Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population. International-journal

Yoshihiko Furuta, Masato Akiyama, Naoki Hirabayashi, Takanori Honda, Mao Shibata, Tomoyuki Ohara, Jun Hata, Chikashi Terao, Yukihide Momozawa, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

NPJ genomic medicine　9　(1)　59-59　2024/11/13

DOI： 10.1038/s41525-024-00431-x 　

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The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47). The lead variant of GFAP was a common missense variant (p.D295N) in East Asians. Meta-GWAS using the publicly available summary statistics of UK Biobank identified one previously unreported locus 6q23.2 (SLC2A12). Integration with expression quantitative trait locus data implied the newly identified locus affects SLC2A12 expression. The effect sizes of 20 lead variants at the WML-associated loci were moderately correlated between JPSC-AD and UK Biobank. These results indicate that the alteration in GFAP protein caused by the common missense variant in East Asians influences the WML volume.
Parent-offspring brain similarity: Specificities and commonalities across gender combinations - the Transmit Radiant Individuality to Offspring (TRIO) study

Izumi Matsudaira, Ryo Yamaguchi, Yasuyuki Taki

2024/10/06
Publisher: Cold Spring Harbor Laboratory
DOI： 10.1101/2024.10.05.616578 　

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Research suggests that parent-offspring brain similarities may underlie intergenerational transmission of psychopathology. However, most studies have focused on mothers and offspring, with few including fathers. This study aimed to extend understanding of parent-offspring neural similarities by examining parent-offspring trios. The study included 152 Japanese biological parent-offspring trios who participated in the Transmit Radiant Individuality to Offspring (TRIO) study. We analyzed the parent-offspring similarities in brain structural features (cortical thickness, surface area, local gyrification index, and subcortical volume) across different parent-offspring gender combinations (father-son, father-daughter, mother-son, and mother-daughter). Additionally, we investigated the relationship between brain similarities and similarities in intelligence and personality traits in parents and offspring. Our findings confirmed that correlations in brain structural features between father-offspring or mother-offspring dyads were significantly stronger than those between unrelated individuals. Notably, both sons and daughters exhibited brain regions similar to their fathers only, mothers only, both parents, or neither parent. Furthermore, a significant association was observed between similarities in general intelligence and the surface area of auditory regions in both father-offspring and mother-offspring dyads. These results provide valuable insights into the genetic and environmental factors influencing brain development and aging across generations. This study is expected to contribute to future research elucidating the mechanisms underlying the intergenerational transmission of psychiatric disorders.
ApoE陽性老人斑を可視化する蛍光プローブの同定

原田龍一, 工藤楓, 工藤幸司, 谷内一彦, 瀧靖之, 古本祥三, 岡村信行

Dementia Japan　38　(4)　698-698　2024/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function. International-journal

Ayano Shima, Moeko Noguchi-Shinohara, Shutaro Shibata, Yuta Usui, Yasuko Tatewaki, Benjamin Thyreau, Jun Hata, Tomoyuki Ohara, Takanori Honda, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Hisao Nishijo, Toshiharu Ninomiya, Kenjiro Ono

npj aging　10　(1)　39-39　2024/09/09

DOI： 10.1038/s41514-024-00164-2 　

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We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A1c (HbA1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.
A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study.

Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

Journal of epidemiology　2024/07/06

DOI： 10.2188/jea.JE20240099 　

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BackgroundDementia is the leading cause of disability and imposes a significant burden on society. Previous studies have suggested an association between metabolites and cognitive decline. Although the metabolite composition differs between Western and Asian populations, studies targeting Asian populations remain scarce.MethodsThis cross-sectional study used data from a cohort survey of community-dwelling older adults aged ≥ 60 years living in Miyagi, Japan, conducted by Tohoku Medical Megabank Organization between 2013 and 2016. Forty-three metabolite variables quantified using nuclear magnetic resonance spectroscopy were used as explanatory variables. Dependent variable was the presence of cognitive decline (≤ 23 points), assessed by the Mini-Mental State Examination. Principal component (PC) analysis was performed to reduce the dimensionality of metabolite variables, followed by logistic regression analysis to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for cognitive decline.ResultsA total of 2,940 participants were included (men: 49.0%, mean age: 67.6 years). Among them, 1.9% showed cognitive decline. The first 12 PC components (PC1-PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR = 0.89; 95% CI, 0.80-0.98). PC2, which mainly included ketone bodies, was associated with cognitive decline (OR = 1.29; 95% CI, 1.11-1.51). PC3, which included amino acids, was associated with lower odds of cognitive decline (OR = 0.81; 95% CI, 0.66-0.99).ConclusionAmino acids are protectively associated with cognitive decline, whereas ketone metabolites are associated with higher odds of cognitive decline.
自記式問診票を通じた聴覚の自己評価とオージオグラムの比較検討

冨田尚希, 加藤大雅, 佐藤剛史, 内林俊洋, 本蔵陽平, 鈴木淳, 中瀬泰然, 瀧靖之, 香取幸夫

日本老年医学会雑誌　61　(Suppl.)　181-181　2024/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline. International-journal

Hiroyuki Nakamura, Moeko Noguchi-Shinohara, Mai Ishimiya-Jokaji, Yutaka Kobayashi, Mikana Isa, Kentaro Ide, Toshihiro Kawano, Shuichi Kawashiri, Kazuhiro Uchida, Yasuko Tatewaki, Yasuyuki Taki, Tomoyuki Ohara, Toshiharu Ninomiya, Kenjiro Ono

npj aging　10　(1)　20-20　2024/03/22

DOI： 10.1038/s41514-024-00146-4 　

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Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclear. We conducted a population-based longitudinal cohort study in Nakajima, Nanao City, Japan. Between 2016 and 2018, 2454 residents aged ≥60 participated, covering 92.9% of the local age demographics. This study used comprehensive approach by combining detailed dental examinations, dietary assessments, magnetic resonance imaging (MRI) analysis, and cognitive evaluations. Tooth loss, even in cognitively normal individuals, is associated with parahippocampal gyrus atrophy and increased WMH volume, both of which are characteristics of dementia. Tooth loss was associated with altered dietary patterns, notably a reduction in plant-based food intake and an increase in fatty, processed food intake. This study highlights a possible preventative pathway where oral health may play a significant role in preventing the early neuropathological shifts associated with dementia.
Diagnostic approach with Z-score mapping to reduce artifacts caused by cerebral atrophy in regional CBF assessment of mild cognitive impairment (MCI) and Alzheimer's disease by [99mTc]-ECD and SPECT.

Ikuo Odano, Fumio Maeyatsu, Tetsuo Hosoya, Mami Asari, Kentaro Oba, Yasuyuki Taki

Japanese journal of radiology　2024/02/14

DOI： 10.1007/s11604-023-01526-8 　

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PURPOSE: The aim of this study was to develop a novel approach that enhanced diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and early Alzheimer's disease (AD) using cerebral perfusion SPECT by minimizing artifacts caused by cerebral atrophy. MATERIALS AND METHODS: [99mTc]-ECD and SPECT studies were performed on 15 cognitively normal patients, 40 patients with MCI, and 16 patients with AD. SPECT images were compared using SPM. The atrophy correction method was incorporated to reduce artifacts through the MRI masking procedure. Regional Z-score, percent extent, and atrophy correction rate were obtained and compared. The Z-score mapping program was structured as a single package that ran semi-automatically. RESULTS: The method significantly reduced regional Z-score in most regions, leading to improved estimates. The mean atrophy correction rate ranged from 10.4 to 12.0%. In MCI and AD, the convexities of the frontal and parietal lobes and the posterior medial cerebrum were particularly sensitive to cerebral atrophy, and the Z-scores were overestimated, whereas the posterior cingulate cortex and the cerebellum were less sensitive. The diagnostic accuracy for MCI increased from 67 to 69% and for AD from 78 to 82%. CONCLUSION: The proposed approach provided more precise Z-scores with less over- or underestimation, artifacts, and improved diagnostic accuracy, being recommended for clinical studies.
Association between Gray and White Matter Lesions and Its Involvement in Clinical Symptoms of Alzheimer's-Type Dementia. International-journal

Taizen Nakase, Benjamin Thyreau, Yasuko Tatewaki, Naoki Tomita, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

Journal of clinical medicine　12　(24)　2023/12/12

DOI： 10.3390/jcm12247642 　

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BACKGROUND: Not only gray matter lesions (GMLs) but also white matter lesions (WMLs) can play important roles in the pathology of Alzheimer's disease (AD). The progression of cognitive impairment (CI) and behavioral and psychological symptoms of dementia (BPSD) might be caused by a concerted effect of both GML and WML. OBJECTIVE: This study aimed to investigate the association between GML and WML and how they are involved in the symptoms of CI and BPSD in dementia patients by means of imaging technology. METHODS: Patients in our memory clinic, who were diagnosed with AD-type dementia or amnestic mild cognitive impairment (aMCI) and had undergone both single-photon emission computed tomography (SPECT) and brain MRI, were consecutively enrolled (n = 156; 61 males and 95 females; 79.8 ± 7.4 years old). Symptoms of CI and BPSD were obtained from patients' medical records. For the analysis of GMLs and WMLs, SPECT data and MRI T1-weighted images were used, respectively. This study followed the Declaration of Helsinki, and all procedures were approved by the institutional ethics committee. RESULTS: According to a multivariate analysis, disorientation and disturbed attention demonstrated a relationship between the precuneus and WMLs in both hemispheres. Hyperactivity in BPSD showed multiple correlations between GMLs on both sides of the frontal cortex and WMLs. Patients with aMCI presented more multiple correlations between GMLs and WMLs compared with those with AD-type dementia regarding dementia symptoms including BPSD. CONCLUSION: The interaction between GMLs and WMLs may vary depending on the symptoms of CI and BPSD. Hyperactivity in BPSD may be affected by the functional relationship between GMLs and WMLs in the left and right hemispheres. The correlation between GMLs and WMLs may be changing in AD-type dementia and aMCI.
白質病変の定量化による日本人大規模高齢者集団の食事パターンと認知症に関する研究

陳俐穎, 舘脇康子, Thyreau Benjamin, 内田和宏, 壹岐ひかり, 中瀬泰然, 中路重之, 前田哲也, 野口もえ子[篠原], 三村將, 中島健二, 伊賀淳一, 竹林実, 二宮利治, 瀧靖之

Dementia Japan　37　(4)　666-666　2023/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
臨床的アルツハイマー病疑い患者におけるアミロイドPETとSPECT・MMSEの関連性の検討

山崎真瞳子, 舘脇康子, 中瀬泰然, 村中美千帆, 高野由美, 冨田尚希, 児玉裕康, 瀧靖之

Dementia Japan　37　(4)　657-657　2023/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
ポリファーマシーに関連した問題点の適正化が主要な診療となった5症例の検討

冨田尚希, 村中美千帆, 舘脇康子, 高野由美, 山本修三, 中瀬泰然, 瀧靖之

日本老年医学会雑誌　60　(4)　457-457　2023/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Transmit Radiant Individuality to Offspring (TRIO) study: investigating intergenerational transmission effects on brain development

Izumi Matsudaira, Ryo Yamaguchi, Yasuyuki Taki

Frontiers in Psychiatry　14　2023/09/28
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1150973 　

eISSN： 1664-0640

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Intergenerational transmission is a crucial aspect of human development. Although prior studies have demonstrated the continuity of psychopathology and maladaptive upbringing environments between parents and offspring, the underlying neurobiological mechanisms remain unclear. We have begun a novel neuroimaging research project, the Transmit Radiant Individuality to Offspring (TRIO) study, which focuses on biological parent-offspring trios. The participants of the TRIO study were Japanese parent-offspring trios consisting of offspring aged 10–40 and their biological mother and father. Structural and functional brain images of all participants were acquired using magnetic resonance imaging (MRI). Saliva samples were collected for DNA analysis. We obtained psychosocial information, such as intelligence, mental health problems, personality traits, and experiences during the developmental period from each parent and offspring in the same manner as much as possible. By April 2023, we completed data acquisition from 174 trios consisting of fathers, mothers, and offspring. The target sample size was 310 trios. However, we plan to conduct genetic and epigenetic analyses, and the sample size is expected to be expanded further while developing this project into a multi-site collaborative study in the future. The TRIO study can challenge the elucidation of the mechanism of intergenerational transmission effects on human development by collecting diverse information from parents and offspring at the molecular, neural, and behavioral levels. Our study provides interdisciplinary insights into how individuals’ lives are involved in the construction of the lives of their descendants in the subsequent generation.
海馬亜領域の糖尿病に対する脆弱性

島綾乃, 篠原もえ子, 小松潤史, 柴田修太郎, 坂下泰浩, 村松大輝, 疋島貞雄, ティロー・バンジャマン, 館脇康子, 瀧靖之, 二宮利治, 小野賢二郎

臨床神経学　63　(Suppl.)　S312-S312　2023/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
VBMを用いた緑内障患者における局所脳体積の経時的変化と眼パラメーターの関連

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
VBMを用いた緑内障患者における局所脳体積の経時的変化と眼パラメーターの関連

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　34回　163-163　2023/09
Publisher: 日本緑内障学会
Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons. International-journal

Ayumi Tachibana, Jun-Ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-Ichi Ueno

Journal of geriatric psychiatry and neurology　8919887231195235-8919887231195235　2023/08/03

DOI： 10.1177/08919887231195235 　

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BACKGROUND: Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS: A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS: Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia. CONCLUSIONS: The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.
Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia: The JPSC-AD Study. International-journal

Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

Neurology　2023/07/12

eISSN： 1526-632X

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BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesions volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q value of FDR correction <0.05). The relationships appeared to be partly mediated by depressive symptoms, which accounted for 15% to 29% of the observed associations. DISCUSSION: Lower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.
Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers. International-journal

Ryuichi Harada, Pradith Lerdsirisuk, Yuki Shimizu, Yuka Yokoyama, Yiqing Du, Kaede Kudo, Michinori Ezura, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, Yuya Hatano, Tomohiko Ishihara, Osamu Onodera, Yasushi Iwasaki, Mari Yoshida, Yasuyuki Taki, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai, Shozo Furumoto, Nobuyuki Okamura

Journal of nuclear medicine : official publication, Society of Nuclear Medicine　2023/06/15

DOI： 10.2967/jnumed.123.265593 　

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Tau PET tracers are expected to be sufficiently sensitive to track the progression of age-related tau pathology in the medial temporal cortex. The tau PET tracer N-(4-[18F]fluoro-5-methylpyridin-2-yl)-7-aminoimidazo[1,2-a]pyridine ([18F]SNFT-1) has been successfully developed by optimizing imidazo[1,2-a]pyridine derivatives. We characterized the binding properties of [18F]SNFT-1 using a head-to-head comparison with other reported 18F-labeled tau tracers. Methods: The binding affinity of SNFT-1 to tau, amyloid, and monoamine oxidase A and B was compared with that of the second-generation tau tracers MK-6240, PM-PBB3, PI-2620, RO6958948, JNJ-64326067, and flortaucipir. In vitro binding properties of 18F-labeled tau tracers were evaluated through the autoradiography of frozen human brain tissues from patients with diverse neurodegenerative disease spectra. Pharmacokinetics, metabolism, and radiation dosimetry were assessed in normal mice after intravenous administration of [18F]SNFT-1. Results: In vitro binding assays demonstrated that [18F]SNFT-1 possesses high selectivity and high affinity for tau aggregates in Alzheimer disease (AD) brains. Autoradiographic analysis of tau deposits in medial temporal brain sections from patients with AD showed a higher signal-to-background ratio for [18F]SNFT-1 than for the other tau PET tracers and no significant binding with non-AD tau, α-synuclein, transactiviation response DNA-binding protein-43, and transmembrane protein 106B aggregates in human brain sections. Furthermore, [18F]SNFT-1 did not bind significantly to various receptors, ion channels, or transporters. [18F]SNFT-1 showed a high initial brain uptake and rapid washout from the brains of normal mice without radiolabeled metabolites. Conclusion: These preclinical data suggest that [18F]SNFT-1 is a promising and selective tau radiotracer candidate that allows the quantitative monitoring of age-related accumulation of tau aggregates in the human brain.
In vitroオートラジオグラフィーによる[18F]SMBT-1 PETの妥当性の検証

工藤楓, 原田龍一, 工藤幸司, 瀧靖之, 田代学, 古本祥三, 岡村信行

JSMI Report　16　(2)　71-71　2023/05
Publisher: 日本分子イメージング学会
ISSN： 1882-6490
Co-administration of JQ1, a bromodomain-containing protein 4 inhibitor, enhances the antitumor effect of combretastatin A4, a microtubule inhibitor, while attenuating its cardiotoxicity. International-journal

Haruka Orihara, Min Ma, Yoshiyasu Nagashima, Ryota Tochinai, Shin-Ichi Sekizawa, Daiki Kato, Masahiro Shinada, Susumu Aoki, Naoki Fujita, Takayuki Nakagawa, Yoshiharu Tsuru, Yasuko Tatewaki, Tatsushi Mutoh, Yasuyuki Taki, Ryohei Nishimura, Masayoshi Kuwahara

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie　160　114353-114353　2023/04

DOI： 10.1016/j.biopha.2023.114353 　

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Combretastatin A4 (CA4) inhibits microtubule polymerization, and clinical trials of the prodrug, CA4 disodium phosphate (CA4DP), as an anti-cancer agent have been conducted. However, CA4DP has not been marketed to date because the margin between the effective dose and the cardiotoxic dose is insufficient. Meanwhile, bromodomain-containing protein 4 (BRD4) has been reported to be required for recovery from mitotic arrests induced by anti-microtubule drugs. BRD4 has also been reported to be involved in the progression of heart failure. Therefore, we hypothesized that the combined use of CA4DP with BRD4 inhibitors can enhance the antitumor effect and attenuate CA4DP-induced cardiotoxicity. In this study, the antitumor effect and cardiotoxicity caused by the co-administration of CA4DP with JQ1, a BRD4 inhibitor, were evaluated. CA4 or JQ1 alone reduced the viability of cultured canine mammary tumor cells (CHMp-13a). Viability was further reduced by co-administration, through the suppression of c-Myc. BRD4 positivity in CHMp-13a cytoplasm showed a significant increase when treated with CA4 alone, while the increase was not significant following co-administration. In CHMp-13a xenograft-transplanted mice, co-administration of CA4DP and JQ1 suppressed tumor growth significantly. In CA4DP-induced cardiac injury model rats, echocardiography showed a CA4DP-induced decrease in cardiac function and histopathology showed cardiomyocyte necrosis. Meanwhile, these cardiac changes tended to be milder following the co-administration of CA4DP and JQ1. These results suggest that CA4DP-JQ1 co-administration enhances the antitumor effect of CA4DP while attenuating its cardiotoxicity and therefore potentially open the doors to the development of a novel cancer chemotherapy with reduced cardiotoxicity risks.
CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. International-journal

Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

Kidney medicine　5　(3)　100593-100593　2023/03

DOI： 10.1016/j.xkme.2022.100593 　

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RATIONALE & OBJECTIVE: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. STUDY DESIGN: Population-based cross-sectional study. SETTING & PARTICIPANTS: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. EXPOSURES: UACR and eGFR levels. OUTCOMES: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). ANALYTICAL APPROACH: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. RESULTS: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and <0.001, respectively). Lower eGFR levels were significantly associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. In addition, higher UACR levels, but not lower eGFR, were significantly associated with lower temporal cortex volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio. LIMITATIONS: Cross-sectional study, misclassification of UACR or eGFR levels, generalizability to other ethnicities and younger populations, and residual confounding factors. CONCLUSIONS: The present study demonstrated that higher UACR was associated with brain atrophy, especially in the temporal cortex and hippocampus, and with increased WMLV. These findings suggest that chronic kidney disease is involved in the progression of morphologic brain changes associated with cognitive impairment.
Impact of atrial fibrillation on the cognitive decline in Alzheimer's disease. International-journal

Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Hayato Odagiri, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

Alzheimer's research & therapy　15　(1)　15-15　2023/01/13

DOI： 10.1186/s13195-023-01165-1 　

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BACKGROUND: Atrial fibrillation (AF) is a strong risk factor for Alzheimer's disease (AD) independent of ischemic stroke. However, the clinicopathological impact of AF on the severity of AD has not been well elucidated. We aimed to investigate the clinical differences between dementia patients with AF and those without AF by means of imaging data. METHODS: Following approval from the institutional ethics committee, patients with newly diagnosed AD or amnestic mild cognitive impairment (aMCI) were retrospectively screened (n = 170, 79.5 ± 7.4 years old). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Based on the MRI data, the cerebral volume, cerebral microbleeds (CMBs), periventricular white matter lesions (WMLs), and deep WMLs were evaluated. The regional cerebral blood flow (rCBF) was measured using 123I-IMP SPECT. RESULTS: Of the patients, 14 (8.2%) and 156 (91.8%) had AF (AF group) and sinus rhythm (SR group), respectively. The AF group had significantly lower MMSE scores than the SR group (average [standard deviation (SD)]: 19.4 [4.4] and 22.0 [4.4], respectively; p = 0.0347). Cerebral volume and CMBs did not differ between the two groups. The periventricular WMLs, but not the deep WMLs, were significantly larger in the AF group than in the SR group (mean [SD] mL: 6.85 [3.78] and 4.37 [3.21], respectively; p = 0.0070). However, there was no significant difference in rCBF in the areas related to AD pathology between the two groups. CONCLUSION: AD and aMCI patients with AF showed worse cognitive decline along with larger periventricular WMLs compared to those with SR, although the reduction of rCBF was not different between patients with AF and SR. The white matter lesions may be a more important pathology than the impairment of cerebral blood flow in dementia patients with AF. A larger study is needed to confirm our findings in the future.
Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease. International-journal

Ye Zhang, Yasuko Tatewaki, Taizen Nakase, Yingxu Liu, Naoki Tomita, Benjamin Thyreau, Haixia Zheng, Michiho Muranaka, Yumi Takano, Tatsuo Nagasaka, Yasuyuki Taki

Frontiers in aging neuroscience　15　1227325-1227325　2023

DOI： 10.3389/fnagi.2023.1227325 　

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INTRODUCTION: Present study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD]. METHODS: We retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively. RESULTS: Hs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, pFDR = 0.023) and the left parahippocampal gyrus (β = 0.16, pFDR = 0.029). Post hoc analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, p = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline (r = -0.41, p = 0.013). CONCLUSION: Our study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment.
Pretreatment with tadalafil attenuates cardiotoxicity induced by combretastatin A4 disodium phosphate in rats Peer-reviewed

Yoshiyasu NAGASHIMA, Ryota TOCHINAI, Shin-ichi SEKIZAWA, Daiki KATO, Takayuki NAKAGAWA, Yoshiharu TSURU, Yasuko TATEWAKI, Tatsushi MUTOH, Yasuyuki TAKI, Masayoshi KUWAHARA

Journal of Toxicologic Pathology　2023
Publisher: Japanese Society of Toxicologic Pathology
DOI： 10.1293/tox.2022-0143 　

ISSN： 0914-9198

eISSN： 1881-915X
Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial. International-journal

Taizen Nakase, Yasuko Tatewaki, Izumi Matsudaira, Kouki Kobayashi, Hikari Iki, Haruka Asaoka, Radiztia Ekayantri, Michiho Muranaka, Hiroyuki Murata, Tatsushi Mutoh, Yasuyuki Taki

PloS one　18　(3)　e0280549　2023

DOI： 10.1371/journal.pone.0280549 　

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BACKGROUND AND PURPOSE: Ginkgo biloba extract (GBE) reportedly ameliorates cognitive function in patients with chronic cerebrovascular insufficiency. However, its efficacy in healthy adults is ambiguous. It was reported that concentrations of terpene lactones, active components of GBE that are present in very low concentrations in the brain, were significantly increased following administration of a mixture of GBE, sesame seed, and turmeric (GBE/MST) in mice. This study aims to investigate the effectiveness of GBE/MST on the cognitive function of healthy adults by comparing it with that of GBE alone. METHODS: Altogether, 159 participants providing informed consent will be recruited from a population of healthy adults aged 20-64 years. Normal cognitive function at baseline will be confirmed using the Japanese version of the Montreal Cognitive Assessment battery. Participants will be randomly assigned in a double-blind manner to the GBE/MST, GBE, and placebo groups in a 1:1:1 ratio. The Wechsler Memory Scale, Trail Making Test, and Stroop Color and Word Test will be used to assess the memory and executive functions at baseline and at the endpoint (24 weeks). For biological assessment, resting state functional magnetic resonance imaging (rs-fMRI) will be performed simultaneously with the neuropsychological tests. DISCUSSION: This study aims to obtain data that can help compare the profile changes in memory and executive functions among participants consuming GBE/MST, GBE alone, and placebo for 24 weeks. Alterations in the default mode network will be evaluated by comparing the rs-fMRI findings between baseline and 24 weeks in the aforementioned groups. Our results may clarify the impact of GBE on cognitive function and the functional mechanism behind altered cognitive function induced by GBE components. TRIAL REGISTRATION: This study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; registration number: UMIN000043494). This information can be searched on the website of the International Clinical Trials Registry Platform Search Portal of the World Health Organization under the Japan Primary Registries Network.
Impact of constipation on progression of Alzheimer's disease: A retrospective study. International-journal

Taizen Nakase, Yasuko Tatewaki, Benjamin Thyreau, Tatsushi Mutoh, Naoki Tomita, Shuzo Yamamoto, Yumi Takano, Michiho Muranaka, Yasuyuki Taki

CNS neuroscience & therapeutics　28　(12)　1964-1973　2022/12

DOI： 10.1111/cns.13940 　

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BACKGROUND AND PURPOSE: In terms of the gut-brain axis, constipation has been considered to be an important factor of neurodegenerative diseases, although the exact mechanism is still controversial. Herein, we aimed to investigate the contribution of constipation to the progression of dementia in a retrospective study. METHODS: Patients of Alzheimer's disease(AD) and amnestic mild cognitive impairment were consecutively screened between January 2015 and December 2020, and those of whom brain MRI and neuropsychological tests were performed twice were enrolled in this study. Participants were classified into with constipation (Cons[+], n = 20) and without constipation (Cons[-], n = 64) groups. Laboratory data at the first visit were used. Regression analysis was performed in MMSE, ADAS-Cog, and the volumes of hippocampus on MRI-MPRAGE images and deep white matter lesions (DWMLs) on MRI-FLAIR images obtained at two different time points. RESULTS: The main finding was that the Cons[+] group showed 2.7 times faster decline in cognitive impairment compared with the Cons[-] group, that is, the liner coefficients of ADAS-Cog were 2.3544 points/year in the Cons[+] and 0.8592 points/year in the Cons[-] groups. Ancillary, changes of DWMLs showed significant correlation with the time span (p < 0.01), and the liner coefficients of DWMLs were 24.48 ml/year in the Cons[+] and 14.83 ml/year in the Cons[-] group, although annual rate of hippocampal atrophy was not different between the two groups. Moreover, serum homocysteine level at baseline was significantly higher in the Cons[+] group than Cons[-] group (14.6 ± 6.4 and 11.5 ± 4.2 nmol/ml, respectively: p = 0.03). CONCLUSION: There is a significant correlation between constipation and faster progression of AD symptoms along with expansion of DWMLs.
Mercury levels in hair are associated with reduced neurobehavioral performance and altered brain structures in young adults International-journal

Hikaru Takeuchi, Yuka Shiota, Ken Yaoi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Communications Biology　5　(1)　529-529　2022/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s42003-022-03464-z 　

eISSN： 2399-3642

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Abstract The detrimental effects of high-level mercury exposure on the central nervous system as well as effects of low-level exposure during early development have been established. However, no previous studies have investigated the effects of mercury level on brain morphometry using advance imaging techniques in young adults. Here, utilizing hair analysis which has been advocated as a method for biological monitoring, data of regional gray matter volume (rGMV), regional white matter volume (rWMV), fractional anisotropy (FA) and mean diffusivity (MD), cognitive functions, and depression among 920 healthy young adults in Japan, we showed that greater hair mercury levels were weakly but significantly associated with diminished cognitive performance, particularly on tasks requiring rapid processing (speed measures), lower depressive tendency, lower rGMV in areas of the thalamus and hippocampus, lower rWMV in widespread areas, greater FA in bilaterally distributed white matter areas overlapping with areas of significant rWMV reductions and lower MD of the widely distributed gray and white matter areas particularly in the bilateral frontal lobe and the right basal ganglia. These results suggest that even normal mercury exposure levels in Japan are weakly associated with differences of brain structures and lower neurobehavioral performance and altered mood among young adults.
PERCEIVED SOCIAL ISOLATION IS CORRELATED WITH BRAIN STRUCTURE AND COGNITIVE TRAJECTORY IN ALZHEIMER'S DISEASE

Ye Zhang, Yasuko Tatewaki, Yingxu Liu, Naoki Tomita, Yumi Takano, Taizen Nakase, Tatsushi Mutoh, Yasuyuki Taki

INNOVATION IN AGING　6　772-773　2022/11

eISSN： 2399-5300
Brain Anatomy Alterations and Mental Health Challenges Correlate to Email Addiction Tendency International-journal

Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Brain Sciences　12　(10)　1278-1278　2022/09/22
Publisher: MDPI AG
DOI： 10.3390/brainsci12101278 　

eISSN： 2076-3425

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Despite the widespread use of email, our knowledge regarding the consequences of email addiction is lacking. The purpose of this study was to develop an email addiction tendency scale to evaluate its correlation to behavior and brain structure. Following this, the validity and reliability of the developed scale was investigated. We used voxel-based morphometry, correlation, and univariate regression analysis to assess the relationships between email addiction tendency scores and regional gray and white matter volumes, depression, and nonverbal reasoning abilities in a large sample of healthy young adults (n = 1152; mean age, 20.69 ± 1.84 years). The content validity ratio, content validity index, principal component analysis, and confirmatory factorial analysis all showed that the email addiction tendency scale (EATS) has high validity. Additionally, the Cronbach’s alpha internal consistency and split-half reliability coefficient showed that the EATS has high reliability. We found that email addiction tendency scores were significantly negatively correlated with nonverbal reasoning. We also observed that the email addiction tendency scores were significantly and positively correlated with depression symptom severity and gray matter volume of the left rostrolateral prefrontal cortex (RLPC) in subjects. These results indicate that email addiction tendency is associated with lower mental health outcomes and increased GMV in the left RLPC.
Sex interaction of white matter microstructure and verbal IQ in corpus callosum in typically developing children and adolescents. International-journal

Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

Brain & development　44　(8)　531-539　2022/09

DOI： 10.1016/j.braindev.2022.04.003 　

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BACKGROUND: Childhood is an extremely important time for neural development that has a critical role in human intelligence. Efficient information processing is crucial for higher intelligence, so the intra- or inter-hemispheric interaction is vital. However, the relationship between neuroanatomical connections and intelligence in typically developing children, as well as sex differences in this relationship, remains unknown. METHODS: Participants were 253 typically developing children (121 boys and 132 girls) aged 5-18. We acquired diffusion tensor imaging data and intelligence using an age-appropriate version of the IQ test; Wechsler Intelligence Scale for Children (WISC) or Wechsler Adult Intelligence Scale (WAIS). We conducted whole-brain multiple regression analysis to investigate the association between fractional anisotropy (FA), which reflects white matter microstructural properties, and each composite score of IQ test (full-scale IQ, performance IQ, and verbal IQ). RESULTS: FA was positively correlated with full-scale IQ in bilateral inferior occipitofrontal fasciculus, genu, and splenium of corpus callosum (CC). FA in the right superior longitudinal fasciculus, bilateral inferior longitudinal fasciculus, and splenium of CC were also positively correlated with performance IQ. Furthermore, we found significant sex interaction between FA in the CC and verbal IQ. FA was positively correlated in boys, and negatively correlated in girls. CONCLUSION: Results suggest that efficient anatomical connectivity between parietal and frontal regions is crucial for children's intelligence. Moreover, inter-hemispheric connections play a critical role in verbal abilities in boys.
Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort International-journal

Benjamin Thyreau, Yasuko Tatewaki, Liying Chen, Yuji Takano, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Moeko Noguchi-Shinohara, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Toshiharu Ninomiya, Yasuyuki Taki

HUMAN BRAIN MAPPING　43　(13)　3998-4012　2022/09

DOI： 10.1002/hbm.25899 　

ISSN： 1065-9471

eISSN： 1097-0193
Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study. International-journal Peer-reviewed

Moeko Noguchi-Shinohara, Kenjiro Ono, Sohshi Yuki-Nozaki, Kazuo Iwasa, Masami Yokogawa, Kiyonobu Komai, Benjamin Thyreau, Yasuko Tatewaki, Yasuyuki Taki, Mao Shibata, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Masahito Yamada

Scientific reports　12　(1)　12129-12129　2022/08/01

DOI： 10.1038/s41598-022-16190-7 　

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Physical frailty has been associated with adverse outcomes such as dementia. However, the underlying structural brain abnormalities of physical frailty are unclear. We investigated the relationship between physical frailty and structural brain abnormalities in 670 cognitively unimpaired individuals (mean age 70.1 years). Total brain volume (TBV), hippocampal volume (HV), total white matter hypointensities volume (WMHV), and estimated total intracranial volume (eTIV) on the 3D T1-weighted images were automatically computed using FreeSurfer software. Participants were divided into two states of physical frailty (robust vs. prefrail) based on the revised Japanese version of the Cardiovascular Health Study criteria. The multivariable-adjusted mean values of the TBV-to-eTIV ratio was significantly decreased, whereas that of the WMHV-to-eTIV ratio was significantly increased in the prefrail group compared with the robust group. Slowness, one of the components of physical frailty, was significantly associated with reduced TBV-to-eTIV and HV-to-eTIV ratios, and slowness and weakness were significantly associated with an increased WMHV-to-eTIV ratio. Our results suggest that the prefrail state is significantly associated with global brain atrophy and white matter hypointensities. Furthermore, slowness was significantly associated with hippocampal atrophy.
Impact of Catheter Ablation on Brain Microstructure and Blood Flow Alterations for Cognitive Improvements in Patients with Atrial Fibrillation: A Pilot Longitudinal Study. International-journal

Yasuko Tatewaki, Tatsushi Mutoh, Hirokazu Sato, Akiko Kobayashi, Tomoko Totsune, Benjamin Thyreau, Atsushi Sekiguchi, Taizen Nakase, Tetsuo Yagi, Yasuyuki Taki

Journal of clinical medicine　11　(15)　2022/07/26

DOI： 10.3390/jcm11154346 　

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Atrial fibrillation (AF) predisposes patients to develop cognitive decline and dementia. Clinical and epidemiological data propose that catheter ablation may provide further benefit to improve neurocognitive function in patients with AF, but the underlying mechanism is poorly available. Here, we conducted a pilot prospective study to investigate whether AF ablation can alter regional cerebral blood flow (rCBF) and brain microstructures, using multimodal magnetic resonance imaging (MRI) technique. Eight patients (63 ± 7 years) with persistent AF underwent arterial-spin labeling (ASL) perfusion, 3D T1-structural images and cognitive test batteries before and 6 months after intervention. ASL and structural MR images were spatially normalized, and the rCBF and cortical thickness of different brain areas were compared between pre- and 6-month post-treatment. Cognitive-psychological function was improved, and rCBF was significantly increased in the left posterior cingulate cortex (PCC) (p = 0.013), whereas decreased cortical thickness was found in the left posterior insular cortex (p = 0.023). Given that the PCC is a strategic site in the limbic system, while the insular cortex is known to play an important part in the central autonomic nervous system, our findings extend the hypothesis that autonomic system alterations are an important mechanism explaining the positive effect of AF ablation on cognitive function.
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease. International-journal

Ye Zhang, Yasuko Tatewaki, Yingxu Liu, Naoki Tomita, Tatsuo Nagasaka, Michiho Muranaka, Shuzo Yamamoto, Yumi Takano, Taizen Nakase, Tatsushi Mutoh, Yasuyuki Taki

GeroScience　44　(3)　1563-1574　2022/06

DOI： 10.1007/s11357-022-00584-6 　

ISSN： 2509-2715

eISSN： 2509-2723
RELN rs7341475 Associates with Brain Structure in Japanese Healthy Females. International-journal

Ryo Yamaguchi, Izumi Matsudaira, Hikaru Takeuchi, Tadashi Imanishi, Ryosuke Kimura, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Neuroscience　494　38-50　2022/05/13

DOI： 10.1016/j.neuroscience.2022.05.007 　

ISSN： 0306-4522

eISSN： 1873-7544
Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults.

Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa, Yohei Mukai, Yuji Takahashi, Kazuya Sako, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hiroshi Nagayama, Kenjiro Ono, Atsushi Kono, Kenji Sekiguchi, Shigeki Hirano, Noriko Sato

Annals of nuclear medicine　36　(5)　460-467　2022/05

DOI： 10.1007/s12149-022-01725-9 　

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OBJECTIVE: Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(123)I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults. METHODS: We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject's striatum and then converted the [123I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years). RESULTS: When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding. CONCLUSION: Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.
Perceived stress levels in older adults with financial strain are diminished after theater practice

Izumi Matsudaira, Yasuyuki Taki

F1000Research　2022/05

DOI： 10.12688/f1000research.110340.1 　
Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis from 8695 Old Adults International-journal

Yingxu Liu, Ye Zhang, Benjamin Thyreau, Yasuko Tatewaki, Izumi Matsudaira, Yuji Takano, Naoki Hirabayashi, YoshihikTo Furuta, Hata Jun, Toshiharu Ninomiya, Yasuyuki Taki

The Journals of Gerontology: Series A　77　(9)　1789-1797　2022/04/20
Publisher: Oxford University Press (OUP)
DOI： 10.1093/gerona/glac093 　

ISSN： 1079-5006

eISSN： 1758-535X

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Abstract Altruistic social activity, such as giving support to others, has shown protective benefits on dementia risk and cognitive decline. However, the pathological mechanism is unclear. In the present study, we investigated the association between altruistic social activity and brain regional gray matter. Furthermore, to explore the psychological interplay in altruistic social activity, we tested mediating effect of depressive symptoms on brain regional gray matter. We performed a cross-sectional Voxel-Based Morphology (VBM) analysis including 8695 old adults (72.9±6.1 years) from Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Cohort. We measured altruistic social activities by self-report questionnaire, depressive symptoms by Geriatric Depression Scale (GDS)-short version. We employed the whole-brain VBM method to detect relevant structural properties related to altruistic social activity. We then performed multiple regression models to detect the mediating effect of depressive symptoms on particular brain regional gray matter volume while adjusting possible physical and social lifestyle covariables. We found that altruistic social activity is associated with larger gray matter volume in posterior insula, middle cingulate gyrus, hippocampus, thalamus, superior temporal gyrus, anterior orbital gyrus, and middle occipital gyrus. Depressive symptoms mediated over 10% on altruistic social activity and hippocampus volume, over 20% on altruistic social activity and cingulate gyrus volume. Our results indicated that altruistic social activity might preserve brain regional gray matter where are sensitive to aging and cognitive decline. Meanwhile, this association may be explained by indirect effect on depressive symptoms, suggesting that altruistic social activity may mitigate the neuropathology of dementia.
Brain charts for the human lifespan

R. A. I. Bethlehem, J. Seidlitz, S. R. White, J. W. Vogel, K. M. Anderson, C. Adamson, S. Adler, G. S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D. E. Astle, B. Auyeung, M. Ayub, J. Bae, G. Ball, S. Baron-Cohen, R. Beare, S. A. Bedford, V. Benegal, F. Beyer, J. Blangero, M. Blesa Cábez, J. P. Boardman, M. Borzage, J. F. Bosch-Bayard, N. Bourke, V. D. Calhoun, M. M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y. S. Chong, J. H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V. L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. A. Devenyi, M. A. Di Biase, R. Dolan, K. A. Donald, G. Donohoe, K. Dunlop, A. D. Edwards, J. T. Elison, C. T. Ellis, J. A. Elman, L. Eyler, D. A. Fair, E. Feczko, P. C. Fletcher, P. Fonagy, C. E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J. H. Gilmore, D. C. Glahn, I. M. Goodyer, P. E. Grant, N. A. Groenewold, F. M. Gunning, R. E. Gur, R. C. Gur, C. F. Hammill, O. Hansson, T. Hedden, A. Heinz, R. N. Henson, K. Heuer, J. Hoare, B. Holla, A. J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C. R. Jack, A. P. Jackowski, T. Jia, K. A. Johnson, P. B. Jones, D. T. Jones, R. S. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E. A. Kelley, S. Kern, K. W. Kim, M. G. Kitzbichler, W. S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J. D. Lewis, J. Li, W. Liao, C. Liston, M. V. Lombardo, J. Lv, C. Lynch, T. T. Mallard, M. Marcelis, R. D. Markello, S. R. Mathias, B. Mazoyer, P. McGuire, M. J. Meaney, A. Mechelli, N. Medic, B. Misic, S. E. Morgan, D. Mothersill, J. Nigg, M. Q. W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P. M. Pan, C. Pantelis, M. M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C. K. Rollins, R. Romero-Garcia, L. Ronan, M. D. Rosenberg, D. H. Rowitch, G. A. Salum, T. D. Satterthwaite, H. L. Schaare, R. J. Schachar, A. P. Schultz, G. Schumann, M. Schöll, D. Sharp, R. T. Shinohara, I. Skoog, C. D. Smyser, R. A. Sperling, D. J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K. A. Tsvetanov, N. B. Turk-Browne, J. J. Tuulari, C. Tzourio, É. Vachon-Presseau, M. J. Valdes-Sosa, P. A. Valdes-Sosa, S. L. Valk, T. van Amelsvoort, S. N. Vandekar, L. Vasung, L. W. Victoria, S. Villeneuve, A. Villringer, P. E. Vértes, K. Wagstyl, Y. S. Wang, S. K. Warfield, V. Warrier, E. Westman, M. L. Westwater, H. C. Whalley, A. V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H. J. Zar, A. Zettergren, J. H. Zhou, H. Ziauddeen, A. Zugman, X. N. Zuo, C. Rowe, G. B. Frisoni, A. Pichet Binette, E. T. Bullmore, A. F. Alexander-Bloch

Nature　604　(7906)　525-533　2022/04/06
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41586-022-04554-y 　

ISSN： 0028-0836

eISSN： 1476-4687

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Abstract Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight¹. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories² of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones³, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
A psychiatric disorder risk polymorphism of <scp>ITIH3</scp> is associated with multiple neuroimaging phenotypes in young healthy adults International-journal

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono(Tanaka), Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Tadashi Imanishi, Ryuta Kawashima

Psychiatry and Clinical Neurosciences　76　(6)　271-273　2022/04/05
Publisher: Wiley
DOI： 10.1111/pcn.13347 　

ISSN： 1323-1316

eISSN： 1440-1819
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study International-journal

Tatsushi Mutoh, Keiko Kunitoki, Yasuko Tatewaki, Shuzo Yamamoto, Benjamin Thyreau, Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

GeroScience　44　(3)　1325-1338　2022/04/05
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11357-022-00553-z 　

ISSN： 2509-2715

eISSN： 2509-2723

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Nutritional supplementation with medium-chain triglycerides (MCTs) has the potential to increase memory function in elderly patients with frailty and dementia. Our aim was to investigate the effects of MCT on cognitive and gait functions and their relationships with focal brain metabolism and functional connectivity even in healthy older adults. Participants were blindly randomized and allocated to two groups: 18 g/day of MCT oil and matching placebo formula (control) administered as a jelly stick (6 g/pack, ingested three times a day). Gait analysis during the 6-m walk test, cognition, brain focal glucose metabolism quantified by 18F-fluorodeocyglucose positron emission tomography, and magnetic resonance imaging-based functional connectivity were assessed before and after a 3-month intervention. Sixty-three healthy, normal adults (females and males) were included. Compared with the control group, the MCT group showed better balance ability, as represented by the lower Lissajous index (23.1 ± 14.4 vs. 31.3 ± 18.9; P < 0.01), although no time × group interaction was observed in cognitive and other gait parameters. Moreover, MCT led to suppressed glucose metabolism in the right sensorimotor cortex compared with the control (P < 0.001), which was related to improved balance (r = 0.37; P = 0.04) along with increased functional connectivity from the ipsilateral cerebellar hemisphere. In conclusion, a 3-month MCT supplementation improves walking balance by suppressing glucose metabolism, which suggests the involvement of the cerebro-cerebellar network. This may reflect, at least in part, the inverse reaction of the ketogenic switch as a beneficial effect of long-term MCT dietary treatment.
Shame proneness is associated with individual differences in temporal pole white matter structure. International-journal

Carlos Makoto Miyauchi, Hikaru Takeuchi, Yasuyuki Taki, Seishu Nakagawa, Sugiko Hanawa, Atsushi Sekiguchi, Rui Nouchi, Yuko Sassa, Ryuta Kawashima

Social neuroscience　17　(2)　117-126　2022/04

DOI： 10.1080/17470919.2022.2039287 　

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Shame and guilt are distinct negative moral emotions, although they are usually regarded as overlapping affective experiences. Of these two emotions, shame is more closely related to concerns about other people's judgment, whereas guilt is more related to concerns about one's own judgment. Although some studies have tried to identify the psychological process underlying shame as opposed to guilt, there is no clear evidence of brain regions that are specifically relevant to the experience of shame rather than guilt and, more generally, self-blame. We therefore investigated associations between individual differences in shame- and guilt-proneness and the gray and white matter structures of the brain using magnetic resonance imaging and voxel-based morphometry while controlling for associations with guilt- or shame-proneness. To accomplish this goal, we enrolled 590 healthy, right-handed individuals (338 men and 252 women; age, 20.6 ± 1.8 years). We administered a questionnaire to assess shame proneness and guilt proneness. Based on our hypothesis, we found that high shame proneness was associated with decreased regional white matter density only in the right inferior temporal pole, whereas no significant region was associated with guilt. The function of this area may be important for the underlying processes differentiating shame from guilt.
MRIを用いた緑内障患者の経時的な脳構造変化の検討。

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　126　(臨増)　272-272　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. International-journal

MacGregor Thomas, Jonathan Savitz, Ye Zhang, Kaiping Burrows, Ryan Smith, Leandra Figueroa-Hall, Rayus Kuplicki, Sahib S Khalsa, Yasuyuki Taki, Tracy Kent Teague, Michael R Irwin, Fang-Cheng Yeh, Martin P Paulus, Haixia Zheng, On Behalf Of Tulsa Investigators

Life (Basel, Switzerland)　12　(1)　2021/12/28

DOI： 10.3390/life12010043 　

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(1) Background: Growing evidence indicates that inflammation can induce neural circuit dysfunction and plays a vital role in the pathogenesis of major depressive disorder (MDD). Nevertheless, whether inflammation affects the integrity of white matter pathways is only beginning to be explored. (2) Methods: We computed quantitative anisotropy (QA) from diffusion magnetic resonance imaging as an index of white matter integrity and regressed QA on C-reactive protein (CRP), controlling for age, sex, and BMI, in 176 participants with MDD. (3) Results: The QA values of several white matter tracts were negatively correlated with CRP concentration (standardized beta coefficient = -0.22, 95%CI = -0.38--0.06, FDR < 0.05). These tracts included the bilateral cortico-striatal tracts, thalamic radiations, inferior longitudinal fasciculi, corpus callosum (the forceps minor portion and the tapetum portion), cingulum bundles, and the left superior longitudinal fasciculus III. Importantly, the association remained robust after regressing up to twelve potential confounders. The bilateral fornix and a small portion of the thalamic radiation showed a positive association with CRP levels, but these associations did not remain significant after adjusting for confounders. (4) Conclusions: Peripheral inflammation may contribute to the etiology of MDD by impacting the microstructural integrity of brain corticolimbic white matter pathways.
Core belief disruption amid the COVID-19 pandemic in Japanese adults

Izumi Matsudaira, Yuji Takano, Ryo Yamaguchi, Yasuyuki Taki

Humanities and Social Sciences Communications　8　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1057/s41599-021-00976-7 　

eISSN： 2662-9992

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<title>Abstract</title>Due to the rapid spread of the novel coronavirus disease (COVID-19) worldwide, most people have been forced to alter their lifestyles. This situation may affect the mental health of individuals through the disruption of core beliefs about humans, the world, and the self. Therefore, in this study, an online survey of Japanese adults was conducted to investigate the associations between subjective achievement and the burden of cooperation in preventive measures, disruption of core beliefs, and psychological distress. The results showed that pandemic-induced disruption of core beliefs occurred at a relatively low level in the general population of Japan. In addition, the achievement and psychological burden of preventive measures, reduced income due to the pandemic, and stressfulness of the pandemic were significantly associated with the level of the disruption of core beliefs. Moreover, the greater the disruption of core beliefs, the greater the psychological distress. These findings indicate that the violation of fundamental assumptions about life are an important factor determining mental health during a pandemic.
Curiosity–tourism interaction promotes subjective wellbeing among older adults in Japan

Tomoko Totsune, Izumi Matsudaira, Yasuyuki Taki

Humanities and Social Sciences Communications　8　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1057/s41599-021-00748-3 　

eISSN： 2662-9992

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<title>Abstract</title>Aging societies are one of the major problems faced in the modern world. Promoting subjective wellbeing is a key component in helping individuals positively accept and adapt to psychological and physical changes during their aging process. Tourism is one of the activities that have been demonstrated to promote subjective wellbeing. However, motivation for tourism and its benefits to subjective wellbeing among the older adults have rarely been discussed. The current study aimed to investigate whether tourism contributes to the subjective wellbeing of older adults. We examined the relationships between travel frequency, subjective wellbeing, and the personal trait of curiosity, mediated by the factor of family budget situation. The results demonstrated that diverse curiosity motivates individuals to travel; thus, diverse curiosity positively correlates to subjective wellbeing, both directly as well as indirectly through travel frequency. However, this relationship is limited by the factor of family budget, with tourism contributing to the subjective wellbeing of only well-off older adults. This study concludes that tourism has potential to contribute to subjective wellbeing during later stages of life.
Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study

Yuka Kotozaki, Kozo Tanno, Kiyomi Sakata, Eri Takusari, Kotaro Otsuka, Hiroaki Tomita, Ryohei Sasaki, Nobuyuki Takanashi, Takahiro Mikami, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Yasuyuki Taki, Atsushi Shimizu, Jiro Hitomi, Mamoru Satoh, Makoto Sasaki

BMC Public Health　21　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12889-021-10896-5 　

eISSN： 1471-2458

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<title>Abstract</title><sec> <title>Background</title> Social isolation and mental health issues have become a severe problem in disaster areas in the Great East Japan Earthquake. This study examined whether the combination of the house damage and social isolation or the combination of the death of family members and social isolation is associated with depressive symptoms among survivors using the baseline study data of the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study). </sec><sec> <title>Methods</title> We used cross-sectional data from a baseline survey of 48,958 participants (18,423 males, 30,535 females; aged 60.1 ± 11.2 years) to examine the association between social isolation measured by the Lubben social network scale 6 (LSNS-6) and depressive symptoms measured by the Center for Epidemiological Studies-Depressive Scale (CES-D). The presence of social isolation and depressive symptoms was defined by an LSNS-6 score of < 12 and a CES-D score of ≥16, respectively. We performed a logistic regression analysis to determine the multivariable-adjusted odds ratio (95% confidence interval) [AOR (95% CI)] for depressive symptoms according to sex in the social isolation in comparison to without social isolation, and the associations of the combination of the house damage or the death of family members and social isolation and depressive symptoms. </sec><sec> <title>Results</title> Social isolation was significantly associated with depressive symptoms (males: OR = 1.87; 95% CI = 1.72–2.04, females: OR = 2.13; 95% CI = 2.00–2.26). Both males and females respondents with severe house damage and social isolation had a greater risk of depressive symptoms in comparison to those with an undamaged house and without social isolation (males: OR = 3.40; 95% CI = 2.73–4.24, females: OR = 2.92; 95% CI = 2.46–3.46). The risk of depressive symptoms was also higher in both males and females respondents with the death of family members and social isolation in comparison to those without the death of family members and without social isolation (males: OR = 2.18; 95% CI = 1.90–2.50, females: OR = 2.60; 95% CI = 2.35–2.88). </sec><sec> <title>Conclusion</title> The findings suggested that a combination of social isolation and severe house damage and the death of family members caused by a large-scale natural disaster was associated with a higher risk of depressive symptoms although the interaction was not statistically significant. </sec>
Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet. International-journal

Junpei Takeishi, Yasuko Tatewaki, Taizen Nakase, Yumi Takano, Naoki Tomita, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki

International journal of molecular sciences　22　(22)　2021/11/15

DOI： 10.3390/ijms222212310 　

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Recently, type 2 diabetes mellitus (T2DM) has been reported to be strongly associated with Alzheimer's disease (AD). This is partly due to insulin resistance in the brain. Insulin signaling and the number of insulin receptors may decline in the brain of T2DM patients, resulting in impaired synaptic formation, neuronal plasticity, and mitochondrial metabolism. In AD patients, hypometabolism of glucose in the brain is observed before the onset of symptoms. Amyloid-β accumulation, a main pathology of AD, also relates to impaired insulin action and glucose metabolism, although ketone metabolism is not affected. Therefore, the shift from glucose metabolism to ketone metabolism may be a reasonable pathway for neuronal protection. To promote ketone metabolism, medium-chain triglyceride (MCT) oil and a ketogenic diet could be introduced as an alternative source of energy in the brain of AD patients.
Effects of Natural Reduced Water on Cognitive Function, Body Composition, and Psychological Function in Older Adults: Study Protocol for a Randomized Controlled Trial

Takamitsu Shinada, Yuji Takano, Keisuke Kokubun, Hikari Iki, Yasuyuki Taki

Methods and Protocols　4　(4)　73-73　2021/10/14
Publisher: MDPI AG
DOI： 10.3390/mps4040073 　

eISSN： 2409-9279

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Natural reduced water is natural water that contains active hydrogen and reduces oxidation. It is rare in the world, and in Japan, it is produced in the Hita area of Oita Prefecture (Hita Tenryosui water). Previous studies in humans have examined the effects of natural reduced water on diabetes, which is one of the known risks for dementia. Animal studies of natural reduced water have revealed anti-obesity and anti-anxiety effects. However, the effects of natural reduced water on cognitive function, body composition, and psychological function in humans are unknown. Therefore, we investigated the relationship between these items in elderly people who continuously consume natural reduced water. In this study, we recruited participants aged between 65 and 74 years. The participants were randomly and blindly assigned to a natural reduced water (Hita Tenryosui water) group or a control (tap water) group and drank 1 L of water daily for 6 months. Cognitive function, body composition, and psychological function were measured before and after the 6-month intervention period.
都市在住高齢者の認知機能の性差および側頭葉体積との関連

文鐘玉, 新村秀人, 喜田恒, 鈴木航太, 色本涼, 三村將, 瀧靖之

Dementia Japan　35　(4)　630-630　2021/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
Polygenic risk score for bipolar disorder associates with divergent thinking and brain structures in the prefrontal cortex. International-journal

Hikaru Takeuchi, Ryosuke Kimura, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Izumi Matsudaira, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Sugiko Hanawa, Kunio Iizuka, Atsushi Sekiguchi, Tsuyoshi Araki, Carlos Makoto Miyauchi, Shigeyuki Ikeda, Kohei Sakaki, Kelssy H Dos S Kawata, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Tadashi Imanishi, Ryuta Kawashima

Human brain mapping　42　(18)　6028-6037　2021/09/29

DOI： 10.1002/hbm.25667 　

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It has been hypothesized that a higher genetic risk of bipolar disorder (BD) is associated with greater creativity. Given the clinical importance of bipolar disorder and the importance of creativity to human society and cultural development, it is essential to reveal their associations and the neural basis of the genetic risk of bipolar disorder to gain insight into its etiology. However, despite the previous demonstration of the associations of polygenic risk score (PRS) of BD and creative jobs, the associations of BD-PRS and creativity measured by the divergent thinking (CMDT) and regional gray matter volume (rGMV) as well as regional white matter volume (rWMV) have not been investigated. Using psychological analyses and whole-brain voxel-by-voxel analyses, we examined these potential associations in 1558 young, typically developing adult students. After adjusting for confounding variables and multiple comparisons, a greater BD-PRS was associated with a greater total CMDT fluency score, and a significant relationship was found in fluency subscores. A greater BD-PRS was also associated with lower total mood disturbance. Neuroimaging analyses revealed that the BD-PRS was associated with greater rGMV in the right inferior frontal gyrus, which is a consistently affected area in BD, as well as a greater rWMV in the left middle frontal gyrus, which has been suggested to play a central role in the increased creativity associated with the risk of BD with creativity. These findings suggest a relationship between the genetic risk of BD and CMDT and prefrontal cortical structures among young educated individuals.
The influence of NRXN1 on systemizing and the brain structure in healthy adults

Yuka Shiota, Izumi Matsudaira, Hikaru Takeuchi, Chiaki Ono, Hiroaki Tomita, Ryuta Kawashima, Yasuyuki Taki

Brain Imaging and Behavior　16　(2)　692-701　2021/09/16
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11682-021-00530-8 　

ISSN： 1931-7557

eISSN： 1931-7565
Lead exposure is associated with functional and microstructural changes in the healthy human brain. International-journal

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susum Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Communications biology　4　(1)　912-912　2021/07/26

DOI： 10.1038/s42003-021-02435-0 　

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Lead is a toxin known to harm many organs in the body, particularly the central nervous system, across an individual's lifespan. To date, no study has yet investigated the associations between body lead level and the microstructural properties of gray matter areas, and brain activity during attention-demanding tasks. Here, utilizing data of diffusion tensor imaging, functional magnetic resonance imaging and cognitive measures among 920 typically developing young adults, we show greater hair lead levels are weakly but significantly associated with (a) increased working memory-related activity in the right premotor and pre-supplemental motor areas, (b) lower fractional anisotropy (FA) in white matter areas near the internal capsule, (c) lower mean diffusivity (MD) in the dopaminergic system in the left hemisphere and other widespread contingent areas, and (d) greater MD in the white matter area adjacent to the right fusiform gyrus. Higher lead levels were also weakly but significantly associated with lower performance in tests of high-order cognitive functions, such as the psychometric intelligence test, greater impulsivity measures, and higher novelty seeking and extraversion. These findings reflect the weak effect of daily lead level on the excitability and microstructural properties of the brain, particularly in the dopaminergic system.
Cortico-striatal-thalamic loop as a neural correlate of neuroticism in the mind-body interface

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchid, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Ryuta Kawashima

Journal of Psychosomatic Research　149　110590-110590　2021/07
Publisher: Elsevier BV
DOI： 10.1016/j.jpsychores.2021.110590 　

ISSN： 0022-3999
Brain Microstructural Properties Related to Subjective Well-Being: Diffusion Tensor Imaging Analysis. International-journal

Chiaki Terao Maeda, Hikaru Takeuchi, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Ikeda Shigeyuki, Susumu Yokota, Daniele Magistro, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

Social cognitive and affective neuroscience　16　(10)　1079-1090　2021/05/14

DOI： 10.1093/scan/nsab063 　

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Although it is known that health is not merely the absence of disease, the positive aspects of mental health have been less comprehensively researched compared with its negative aspects. Subjective well-being is one of the indicators of positive psychology, and high subjective well-being is considered to benefit individuals in multiple ways. However, the neural mechanisms underlying individual differences in subjective well-being remain unclear, particularly in terms of brain microstructural properties as detected by diffusion tensor imaging. The present study aimed to investigate the relationship between measurements of diffusion tensor imaging (mean diffusivity and fractional anisotropy) and the degree of subjective well-being as measured using a questionnaire. Voxel-based analysis was used to investigate the association between mean diffusivity and subjective well-being scores in healthy young adults (age, 20.7 ± 1.8 years; 695 males and 514 females). Higher levels of subjective well-being were found to be associated with lower mean diffusivity in areas surrounding the right putamen, insula, globus pallidus, thalamus, and caudate. These results indicated that individual subjective well-being is associated with variability in brain microstructural properties.
Childhood socioeconomic status is associated with psychometric intelligence and microstructural brain development. International-journal

Hikaru Takeuchi, Yasuyuki Taki, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

Communications biology　4　(1)　470-470　2021/04/29

DOI： 10.1038/s42003-021-01974-w 　

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Childhood socioeconomic status is robustly associated with various children's cognitive factors and neural mechanisms. Here we show the association of childhood socioeconomic status with psychometric intelligence and mean diffusivity and fractional anisotropy using diffusion tensor imaging at the baseline experiment (N = 285) and longitudinal changes in these metrics after 3.0 ± 0.3 years (N = 223) in a large sample of normal Japanese children (mean age = 11.2 ± 3.1 years). After correcting for confounding factors, cross-sectional and longitudinal analyses show that higher childhood socioeconomic status is associated with greater baseline and baseline to follow-up increase of psychometric intelligence and mean diffusivity in areas around the bilateral fusiform gyrus. These results demonstrate that higher socioeconomic status is associated with higher psychometric intelligence measures and altered microstructural properties in the fusiform gyrus which plays a key role in reading and letter recognition and further augmentation of such tendencies during development. Definitive conclusions regarding the causality of these relationships requires intervention and physiological studies. However, the current findings should be considered when developing and revising policies regarding education.
Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression

Hiroshi Komatsu, Hikaru Takeuchi, Chiaki Ono, Zhiqian Yu, Yoshie Kikuchi, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

Frontiers in Psychiatry　12　2021/03/08
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2021.631475 　

eISSN： 1664-0640

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Recent evidence has indicated that the disruption of oligodendrocytes may be involved in the pathogenesis of depression. Genetic factors are likely to affect trait factors, such as characteristics, rather than state factors, such as depressive symptoms. Previously, a negative self-schema had been proposed as the major characteristic of constructing trait factors underlying susceptibility to depression. Thus, the association between a negative self-schema and the functional single nucleotide polymorphism (SNP) rs1059004 in the <italic>OLIG2</italic> gene, which influences <italic>OLIG2</italic> gene expression, white matter integrity, and cerebral blood flow, was evaluated. A total of 546 healthy subjects were subjected to genotype and psychological evaluation using the Beck Depression Inventory-II (BDI-II) and the Brief Core Schema Scale (BCSS). The rs1059004 SNP was found to be associated with the self-schema subscales of the BCSS and scores on the BDI-II in an allele dose-dependent manner, and to have a predictive impact on depressive symptoms via a negative-self schema. The results suggest the involvement of a genetic factor regulating oligodendrocyte function in generating a negative-self schema as a trait factor underlying susceptibility to depression.
General Intelligence Is Associated with Working Memory-Related Functional Connectivity Change: Evidence from a Large-Sample Study

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Brain Connectivity　11　(2)　89-102　2021/03

DOI： 10.1089/brain.2020.0769 　

ISSN： 2158-0014

eISSN： 2158-0022
Brain Structures and Activity During a Working Memory Task Associated with Internet Addiction Tendency in Young Adults

Saeid Sadeghi, Hikaru Takeuchi, Bita Shalani, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

2021/02/04
Publisher: Research Square
DOI： 10.21203/rs.3.rs-153035/v1 　

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<title>Abstract</title> An increasing number of young people use internet excessively over the last decades, which leads to adverse impacts on individuals and society. The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade; however, due to the small sample sizes of past studies, many findings are inconsistent. Also, the relationship between internet addiction tendency (IAT) and regional brain activity during working memory (WM), a critical cognitive function governing learned behavior, has not been explored. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between IAT score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n= 1,154, mean age, 20.71 ± 1.78 years).We found a significant positive correlation between IAT score and GMV of right supramarginal gyrus (rSMG) and significant negative correlations with WMVs of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex) during a 2-back WM task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in females.These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMVs in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation.
18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies. International-journal

Michinori Ezura, Akio Kikuchi, Nobuyuki Okamura, Aiko Ishiki, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Michiko Kobayashi, Ohito Tano, Shun Ishiyama, Takaaki Nakamura, Ichiro Nakashima, Shunji Mugikura, Ren Iwata, Yasuyuki Taki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki

Frontiers in aging neuroscience　13　761010-761010　2021

DOI： 10.3389/fnagi.2021.761010 　

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Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters. Methods: 18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke's Cognitive Examination-Revised, and Frontal Assessment Battery, Unified Parkinson's Disease Rating Scale Motor Score, and PSP Rating Scale. Results: 18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP. Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.
Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Pancreatic Ductal Adenocarcinoma. International-journal

Yasuko Tatewaki, Chiaki Maeda Terao, Kyohei Ariake, Ryoko Saito, Tatsushi Mutoh, Hideo Shimomura, Fuyuhiko Motoi, Masamichi Mizuma, Hayato Odagiri, Michiaki Unno, Yasuyuki Taki

Frontiers in oncology　11　646141-646141　2021

DOI： 10.3389/fonc.2021.646141 　

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Objectives: Metabolic tumor volume (MTV) on 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is a promising prognostic predictor in pancreatic ductal adenocarcinoma (PDAC). However, the optimal segmentation method and threshold value to determine MTV for PDAC are still unclear. We explored the optimal method and threshold value for the prognostic value of MTV measured on pre-treatment 18F-FDG-PET/CT. Methods: Seventy-three patients with resected PDAC who underwent 18F FDG-PET/CT before surgical resection were enrolled. MTV values of the tumor were measured on FDG-PET/CT by the two fixed-threshold methods using threshold values as 2.0, 2.5, 3.0, and 3.5 for the absolute method and 35%, 40%, 42%, 45%, and 50% for the relative method. Receiver operating characteristic curve analysis for prediction of 1-year survival rates was conducted for determining the optimal threshold values, and we selected the optimal method and threshold value considering area under the curve. The prognostic values of each FDG-PET/CT parameter for disease-specific survival and recurrence-free survival were assessed with Kaplan-Meier method and Cox proportional hazard models. Results: In receiver operating characteristic curve analysis, MTV by the fixed-absolute threshold method based on a threshold value of 3.5 (MTV3.5) performed best in our study with area under the curve 0.724, sensitivity of 65%, and specificity of 75%. In univariate and multivariate analyses, MTV3.5 was significantly associated with disease-specific and recurrence-free survival. Conclusions: MTV3.5 by absolute threshold on pre-treatment FDG-PET/CT was the best independent prognostic predictor in resectable PDAC compared with other absolute threshold values and relative threshold values.
Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan.

Kazuo Kubota, Noriko Tanaka, Yoko Miyata, Hiroshi Ohtsu, Tadaki Nakahara, Setsu Sakamoto, Takashi Kudo, Yoshihiro Nishiyama, Ukihide Tateishi, Koji Murakami, Yuji Nakamoto, Yasuyuki Taki, Tomohiro Kaneta, Joji Kawabe, Shigeki Nagamachi, Tsuyoshi Kawano, Jun Hatazawa, Youichi Mizutani, Shingo Baba, Kazukuni Kirii, Kunihiko Yokoyama, Terue Okamura, Masashi Kameyama, Ryogo Minamimoto, Junwa Kunimatsu, On Kato, Hiroyuki Yamashita, Hiroshi Kaneko, Satoshi Kutsuna, Norio Ohmagari, Akiyoshi Hagiwara, Yoshimi Kikuchi, Masao Kobayakawa

Annals of nuclear medicine　35　(1)　31-46　2021/01

DOI： 10.1007/s12149-020-01533-z 　

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OBJECTIVE: The aim of this multicenter prospective study was to compare the sensitivity of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) with that of 67Ga single photon emission computed tomography (SPECT) for the identification of the site of greatest importance for the final diagnosis of the cause of fever of unknown origin (FUO). METHODS: The study participants consisted of patients with an axillary temperature ≥ 38.0 °C on ≥ 2 occasions within 1 week, with repeated episodes for ≥ 2 weeks prior to providing consent, and whose final diagnosis after undergoing specific examinations, including a chest-to-abdomen CT scan, was uncertain. All the patients underwent FDG-PET/CT imaging first, followed by 67Ga-SPECT imaging within 3 days. The results of the FDG-PET/CT and 67Ga-SPECT examinations were reviewed by the central image interpretation committee (CIIC), which was blinded to all other clinical information. The sensitivities of FDG-PET/CT and 67Ga-SPECT were then evaluated with regard to identifying the site of greatest importance for a final diagnosis of the cause of the fever as decided by the patient's attending physician. The clinical impacts (four grades) of FDG-PET/CT and 67Ga-SPECT on the final diagnosis were evaluated. RESULTS: A total of 149 subjects were enrolled in this study between October 2014 and September 2017. No adverse events were identified among the enrolled subjects. Twenty-one subjects were excluded from the study because of deviations from the study protocol. Among the 128 remaining subjects, a final diagnosis of the disease leading to the appearance of FUO was made for 92 (71.9%) subjects. The final diagnoses in these 92 cases were classified into four groups: noninfectious inflammatory disease (52 cases); infectious disease (31 cases), malignancy (six cases); and other (three cases). These 92 subjects were eligible for inclusion in the study's analysis, but one case did not meet the PET/CT image acquisition criteria; thus, PET/CT results were analyzed for 91 cases. According to the patient-based assessments, the sensitivity of FDG-PET/CT (45%, 95% CI 33.1-58.2%) was significantly higher than that for 67Ga-SPECT (25%, 95% CI 15.5-37.5%) (P = 0.0029). The clinical impact of FDG-PET/CT (91%) was also significantly higher than that for 67Ga-SPECT (57%, P < 0.001). CONCLUSIONS: FDG-PET/CT showed a superior sensitivity to 67Ga-SPECT for the identification of the site of greatest importance for the final diagnosis of the cause of FUO.
Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) International-journal Peer-reviewed

Toshiharu Ninomiya, Shigeyuki Nakaji, Tetsuya Maeda, Masahito Yamada, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Tomoyuki Ohara, Jun Hata, Yoshihiro Kokubo, Kazuhiro Uchida, Yasuyuki Taki, Shuzo Kumagai, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yukihide Momozawa, Masato Akiyama, Michiaki Kubo, Manabu Ikeda, Shigenobu Kanba, Yutaka Kiyohara

Environmental Health and Preventive Medicine　25　(1)　64-64　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12199-020-00903-3 　

ISSN： 1342-078X

eISSN： 1347-4715

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<title>Abstract</title> <sec> <title>Background</title> The burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction. </sec> <sec> <title>Methods</title> The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, population-based prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses. </sec> <sec> <title>Results</title> The baseline survey was conducted from 2016 to 2018. The follow-up surveys are ongoing. A total of 11,410 individuals aged 65 years or older participated in the study. The mean age was 74.4 years, and 41.9% were male. The prevalence of dementia at baseline was 8.5% in overall participants. However, it was 16.4% among three sites where additional home visit and/or nursing home visit surveys were performed. Approximately two-thirds of dementia cases at baseline were Alzheimer’s disease. </sec> <sec> <title>Conclusions</title> The prospective cohort data from the JPSC-AD will provide valuable insights regarding the risk factors and etiology of dementia as well as for the development of predictive models and diagnostic markers for the future onset of dementia. The findings of this study will improve our understanding of dementia and provide helpful information to establish effective preventive strategies for dementia in Japan. </sec>
The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity Peer-reviewed

Hikarua Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Seishu Nakagawa, Kunio Iizuka, Kohei Sakaki, Tsuyoshi Araki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Sugiko Hanawa, Daniele Magistro, Yuka Kotozaki, Yukako Sasaki, Kelssy H. dos S. Kawata, Ryuta Kawashima

Scientific Reports　10　(1)　2020/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-020-69438-5 　

eISSN： 2045-2322
地域専門病院における高齢者虚血性脳卒中の積極的治療に関する検討

山本修三, 武藤達士, 鶴谷尚信, 渡部憲昭, 米谷元裕, 瀧靖之, 安井信之

日本救急医学会雑誌　31　(11)　1557-1557　2020/11
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
心房細動のアブレーション治療による認知機能改善効果と局所脳血流の変化に関する検討

榎亮, 舘脇康子, 山本修三, 佐藤弘和, 小林亜紀子, 戸恒智子, 高野由美, 武藤達士, 八木哲夫, 瀧靖之

Dementia Japan　34　(4)　492-492　2020/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
非痙攣性てんかん重積の早期診断にMRI-ASL灌流画像が有用であった症例

山本修三, 武藤達士, 舘脇康子, 高野由美, 鶴谷尚信, 渡部憲昭, 斎藤博, 米谷元裕, 荒井啓行, 瀧靖之, 安井信之

Dementia Japan　34　(4)　497-497　2020/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
緑内障におけるMRIを用いた部位別の脳一次視覚野と推定網膜神経節細胞数の関連

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　31回　145-145　2020/10
Publisher: 日本緑内障学会
Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Hikaru Takeuchi, Hiroaki Tomita, Ryan Browne, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral Cortex　31　(1)　672-680　2020/09/21
Publisher: Oxford University Press (OUP)
DOI： 10.1093/cercor/bhaa251 　

ISSN： 1047-3211

eISSN： 1460-2199

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<title>Abstract</title> The APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.
Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment? Peer-reviewed

Keishi Miyazawa, Hisanori Fukunaga, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki

International Journal of Molecular Sciences　21　(16)　5783-5783　2020/08/12
Publisher: MDPI AG
DOI： 10.3390/ijms21165783 　

eISSN： 1422-0067

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Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the group of lipid mediators that actively regulate it—i.e., specialized pro-resolving lipid mediators (SPMs)—attracted attention in recent years as therapeutic targets. This review focuses on the following three specific SPMs and summarizes their relationships to AD, as they were shown to effectively address and reduce the risk of AD-related neuroinflammation: maresin 1 (MaR1), resolvin D1 (RvD1), and neuroprotectin D1 (NPD1). These three SPMs are metabolites of docosahexaenoic acid (DHA), which is contained in fish oils and is thus easily available to the public. They are expected to become incorporated into promising avenues for preventing and treating AD in the future.
Association between resting-state functional connectivity and reading in two writing systems in Japanese children with and without developmental dyslexia Peer-reviewed

Teruo Hashimoto, Hiroki Higuchi, Akira Uno, Susumu Yokota, Kohei Asano, Yasuyuki Taki, Ryuta Kawashima

Brain Connectivity　2020/06/21
Publisher: Mary Ann Liebert Inc
DOI： 10.1089/brain.2020.0759 　

ISSN： 2158-0014

eISSN： 2158-0022
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease

Yumi Takano, Yasuko Tatewaki, Tatsushi Mutoh, Naoya Morota, Izumi Matsudaira, Benjamin Thyreau, Tatsuo Nagasaka, Hayato Odagiri, Shuzo Yamamoto, Hiroyuki Arai, Yasuyuki Taki

Frontiers in Aging Neuroscience　12　2020/06/17
Publisher: Frontiers Media SA
DOI： 10.3389/fnagi.2020.00178 　

eISSN： 1663-4365
Learning a cortical parcellation of the brain robust to the MRI segmentation with convolutional neural networks. International-journal Peer-reviewed

Benjamin Thyreau, Yasuyuki Taki

Medical image analysis　61　101639-101639　2020/04

DOI： 10.1016/j.media.2020.101639 　

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The parcellation of the human cortex into meaningful anatomical units is a common step of various neuroimaging studies. There have been multiple successful efforts to process magnetic resonance (MR) brain images automatically and identify specific anatomical regions, following atlases defined from cortical landmarks. Those definitions usually rely first on a high-quality brain surface reconstruction. On the other hand, when high accuracy is not a requirement, simpler methods based on warping a probabilistic atlas have been widely adopted. Here, we develop a cortical parcellation method for MR brain images based on Convolutional Neural Networks (ConvNets), a machine-learning method, with the goal of automatically transferring the knowledge obtained from surface analyses onto something directly applicable on simpler volume data. We train a ConvNet on a large (thousand) set of cortical ribbons of multiple MRI cohorts, to reproduce parcellations obtained from a surface method, in this case FreeSurfer. Further, to make the model applicable in a broader context, we force the model to generalize to unseen segmentations. The model is evaluated on unseen data of unseen cohorts. We characterize the behavior of the model during learning, and quantify its reliance on the dataset itself, which tends to give support for the necessity of large training sets, augmentation, and multiple contrasts. Overall, ConvNets can provide an efficient way to parcel MRI images, following the guidance established within more complex methods, quickly and accurately. The trained model is embedded within a open-source parcellation tool available at https://github.com/bthyreau/parcelcortex.
Increased grey matter volume of the right superior temporal gyrus in healthy children with autistic cognitive style: A VBM study

Akiko Kobayashi, Susumu Yokota, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

BRAIN AND COGNITION　139　2020/03

DOI： 10.1016/j.bandc.2019.105514 　

ISSN： 0278-2626

eISSN： 1090-2147
近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

面高宗子, 舘脇康子, 檜森紀子, 津田聡, 武藤達士, ティロー・バンジャマン, 松平泉, 川島隆太, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
緑内障患者におけるMRIを用いた脳一次視覚野の部位別変化と各種眼科検査の関連

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　298-298　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
近視を有する緑内障患者の3D T2強調MRIによる眼球形状と体積の定量的解析

面高宗子, 舘脇康子, 檜森紀子, 津田聡, 武藤達士, ティロー・バンジャマン, 松平泉, 川島隆太, 瀧靖之, 中澤徹

日本眼科学会雑誌　124　(臨増)　172-172　2020/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer’s disease Peer-reviewed

Yumi Takano, Tatsushi Mutoh, Yasuko Tatewaki, Toshiki Seki, Shuzo Yamamoto, Hayato Odagiri, Hiroyuki Arai, Yasuyuki Taki

Clinical and Experimental Pharmacology and Physiology　47　(3)　365-371　2020/03/01

DOI： 10.1111/1440-1681.13217 　

ISSN： 0305-1870

eISSN： 1440-1681
Association of iron levels in hair with brain structures and functions in young adults. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)　58　126436-126436　2020/03

DOI： 10.1016/j.jtemb.2019.126436 　

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BACKGROUND: Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. METHODS: Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. RESULTS: Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. CONCLUSION: These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
Convergent creative thinking performance is associated with white matter structures: Evidence from a large sample study. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Izumi Matsudaira, Shigeyuki Ikeda, Kelssy H Dos S Kawata, Rui Nouchi, Kohei Sakaki, Seishu Nakagawa, Takayuki Nozawa, Susumu Yokota, Tsuyoshi Araki, Sugiko Hanawa, Ryo Ishibashi, Shohei Yamazaki, Ryuta Kawashima

NeuroImage　210　116577-116577　2020/01/22

DOI： 10.1016/j.neuroimage.2020.116577 　

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In laboratory settings, creativity is measured using tasks of divergent as well as convergent thinking. It has been suggested that brain connectivity is important for creativity. In the present study, we investigated the associations of convergent thinking performance of compound Remote Associates Test (CRAT) with fractional anisotropy (FA) in diffusion tensor imaging and regional white matter (WM) volume (rWMV) in voxel-based morphometry in a large sample of healthy young adults (360 males and 280 females; mean age: 20.9 years, SD = 1.6). We showed that CRAT performance was positively correlated with WM pathway property (i.e., FA) in the left fronto-occipital fasciculus and the left inferior longitudinal fasciculus, which play important roles in processing of language and concept. Further, CRAT performance was negatively correlated with rWMV in the widespread frontal temporal subcortical and cerebellar WM areas, suggesting the unique association of convergent thinking with WM connectivity.
Transcatheter aortic valve implantation improves cognitive function associated with increased cerebral blood flow in elderly patients with severe aortic stenosis. International-journal Peer-reviewed

Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Kentaro Takanami, Yoku Kikuchi, Jun Takahashi, Satoshi Miyata, Naoki Tomita, Kiichiro Kumagai, Yasuyuki Taki, Yoshikatsu Saiki, Hiroyuki Arai, Hiroaki Shimokawa

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology　2020/01/21

DOI： 10.4244/EIJ-D-19-00489 　

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AIMS: The aim of this study was to examine the mechanisms of cognitive impairment and reversibility in elderly patients with severe aortic stenosis (AS) after transcatheter aortic valve implantation (TAVI) with a special reference to cerebral blood flow (CBF). METHODS AND RESULTS: We examined 15 elderly patients with severe AS (mean age 83.2±4.5 years, 12 female) who underwent TAVI. Before and 3 months after TAVI, we evaluated cognitive function with the Logical Memory II (LM II), cardiac output (CO) with echocardiography, and CBF with 99mTc single-photon emission computed tomography (SPECT). LM II score and CO were significantly increased after TAVI compared with baseline (P<0.01 for LM II, P<0.005 for CO). Notably, CBF in the local regions, including that in the right hippocampus, was significantly increased after TAVI (P<0.005 at each voxel). The patients with increased CO after TAVI also showed significantly increased CBF in the right hippocampus compared with those without it (P<0.01). Importantly, CBF in the right hippocampus were positively correlated with LM II scores (P<0.05). CONCLUSIONS: These results provide the first evidence that TAVI may improve cognitive functions associated with increased cerebral perfusion especially in the hippocampus in elderly patients with severe AS.
Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2020/01/11

DOI： 10.2188/jea.JE20190271 　

ISSN： 0917-5040

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BackgroundWe established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environmental interactions on the incidence of major diseases such as cancer and cardiovascular diseases.MethodsWe asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria was aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), for example, carotid echography, calcaneal ultrasound bone mineral density, and so on. All participants agreed to measure genome information and to distribute their information widely.ResultsAs a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants with Type 1 survey were more likely to have psychological distress than those of Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents regardless of sex.ConclusionThis cohort comprised large sample size and it contains information on disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.
Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure. International-journal Peer-reviewed

Hideaki Suzuki, Yasuharu Matsumoto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

International journal of cardiology　2020/01/10

DOI： 10.1016/j.ijcard.2020.01.019 　

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BACKGROUND: Although depressive symptoms increased mortality and hospitalization in chronic heart failure (CHF) patients, the underlying mechanism remains unclear. The aim of this study was to investigate whether an alteration in hippocampal perfusion, which is the neural substrate of depressive symptoms, is associated with changes in cardiac structures and/or functions in CHF patients. METHODS: We used baseline data of 70 CHF patients (66.8 ± 8.9 yrs, 32.5% women), including cerebral blood flow (CBF) in the hippocampus, geriatric depression scale (GDS) scores and echocardiographic parameters, in the Brain Assessment and Investigation in Heart Failure Trial (B-HeFT) (UMIN000008584). Echocardiography was repeated at 3.1 ± 0.5 years after the baseline evaluation. We first tested voxel-wise regression model with hippocampal CBF as dependent variable and each of echocardiographic parameter change as independent variable, adjusted for age and sex. Structural equation modeling was used to test a mediation effect of cognitive test scores on associations between hippocampal perfusion and changes in cardiac structures and/or functions. RESULTS: Baseline anterior hippocampal CBF was negatively correlated with changes in left ventricular posterior wall thickness (PWT) (P < 0.05 with family-wise error corrections). An existence of depressive symptoms was positively correlated with the baseline anterior CBF and negatively with the PWT changes (P < 0.05, both). There were both direct effects of the baseline anterior hippocampal CBF on PWT thinning and effects mediated through the depressive symptoms (P < 0.05, both). CONCLUSIONS: This study provides the first evidence that the alteration in hippocampal perfusion may lead to changes in cardiac structures via increase in depressive symptoms in CHF patients.
Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms Peer-reviewed

Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Ikeda S, Yokota S, Magistro D, Sassa Y, Kawashima R

Scientific Reports　in press　(1)　2020

DOI： 10.1038/s41598-020-69277-4 　

ISSN： 2045-2322
Effects of training of shadowing and reading aloud of second language on working memory and neural systems Peer-reviewed

Takeuchi H, Maruyama T, Taki Y, Motoki K, Jeong H, Kotozaki Y, Shinada T, Nakagawa S, Nouchi R, Iizuka K, Yokoyama R, Yamamoto Y, Hanawa S, Araki T, Sakaki K, Sasaki Y, Magistro D, Kawashima R

Brain Imaging and Behavior　in press　2020
Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity Peer-reviewed

Komatsu H, Takeuchi H, Kikuchi Y, Ono C, Yu Z, Iizuka K, Takano Y, Kakuto Y, Funakoshi S, Ono T, Ito J, Kunii Y, Hino M, Nagaoka A, Iwasaki Y, Yamamori H, Yasuda Y, Fujimoto M, Azechi H, Kudo N, Hashimoto R, Yabe H, Yoshida M, Saito Y, Kakita A, Fuse N, Kawashima R, Taki Y, Tomita H

Schizophrenia Bulletin　in press　2020
Originality of divergent thinking is associated with working memory–related brain activity: evidence from a large sample study Peer-reviewed

Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakak K, Sassa Y, Nozawa T, Ikeda S, Yokota S, Magistro D, Kawashima R

Neuroimage　in press　116825-116825　2020

DOI： 10.1016/j.neuroimage.2020.116825 　
Adverse motor effects of progressive supranuclear palsy with frontal lobe signs: A case report

Keiko Kunitoki, Tatsushi Mutoh, Hiroyuki Arai, Yasuyuki Taki

Geriatrics and Gerontology International　19　(11)　1184-1186　2019/11/01

DOI： 10.1111/ggi.13775 　

ISSN： 1444-1586

eISSN： 1447-0594
経カテーテル的大動脈弁置換術後に認知機能が改善した超高齢重症大動脈弁狭窄症の1例

土屋聡, 松本泰治, 鈴木秀明, 菊地翼, 高橋潤, 熊谷紀一郎, 冨田尚希, 瀧靖之, 荒井啓行, 下川宏明

日本老年医学会雑誌　56　(4)　547-548　2019/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
高齢女性の骨量減少とアルツハイマー型認知症の脳血流低下領域との関係

関俊樹, 武藤達士, 高野由美, 山本修三, 舘脇康子, 荒井啓行, 瀧靖之

Dementia Japan　33　(4)　553-553　2019/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images. Peer-reviewed

Tatewaki Y, Mutoh T, Omodaka K, Thyreau B, Matsudaira I, Furukawa H, Yamada K, Kunitoki K, Kawashima R, Nakazawa T, Taki Y

Scientific reports　9　(1)　15148　2019/10

DOI： 10.1038/s41598-019-51611-0 　
Performance of Electrical Velocimetry for Noninvasive Cardiac Output Measurements in Perioperative Patients after Subarachnoid Hemorrhage Peer-reviewed

Tatsushi Mutoh, Kazumasu Sasaki, Shuzo Yamamoto, Nobuyuki Yasui, Tatsuya Ishikawa, Yasuyuki Taki

Journal of Neurosurgical Anesthesiology　31　(4)　422-427　2019/10/01

DOI： 10.1097/ANA.0000000000000519 　

ISSN： 0898-4921

eISSN： 1537-1921
Clinical utility of a semiquantitative method using lumbar radiography as a screening tool for osteoporosis in elderly subjects Peer-reviewed

Keiko Kunitoki, Tatsushi Mutoh, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki

Medical Science Monitor　25　6917-6923　2019/09/14

DOI： 10.12659/MSM.917035 　

ISSN： 1234-1010

eISSN： 1643-3750
Assessment of gait symmetry in elderly women with low bone mineral density using a portable trunk accelerometer: A pilot study Peer-reviewed

Yumi Takano, Tatsushi Mutoh, Yasuko Tatewaki, Shuzo Yamamoto, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki

Medical Science Monitor　25　6669-6674　2019/09/05

DOI： 10.12659/MSM.916763 　

ISSN： 1234-1010

eISSN： 1643-3750
高齢女性の骨量減少と認知機能に関連した脳血流低下領域との関係医用画像による骨-脳連関の視覚化

高野由美, 武藤達士, 舘脇康子, 山本修三, 荒井啓行, 瀧靖之

日本骨粗鬆症学会雑誌　5　(Suppl.1)　317-317　2019/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
Development and exploration of a Japanese version of the cerebral palsy quality of life for children questionnaire for primary caregivers: a pilot study. Peer-reviewed

Mutoh T, Mutoh T, Kurosaki H, Shimomura H, Taki Y

Journal of physical therapy science　31　(9)　724-728　2019/09

DOI： 10.1589/jpts.31.724 　

ISSN： 0915-5287
Updated understanding of WRN variants using the Japanese whole-genome reference panel 3.5KJPNv2. International-journal International-coauthorship Peer-reviewed

Fukunaga H, Prise KM, Taki Y

Geriatrics & Gerontology International　19　(9)　961-962　2019/09
Publisher:
DOI： 10.1111/ggi.13724 　

ISSN： 1444-1586
Mean diffusivity associated with trait emotional intelligence. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Social cognitive and affective neuroscience　14　(8)　871-883　2019/08/31

DOI： 10.1093/scan/nsz059 　

ISSN： 1749-5016

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Previous neuroimaging studies have suggested that the neural bases of trait emotional intelligence (TEI) lie in the social cognition network (SCN) and the somatic marker circuitry (SMC). The current study was the first to investigate the associations of total TEI factors and subfactors with mean diffusivity (MD) of these networks as well as regional MD of the dopaminergic system (MDDS). We found that TEI intrapersonal factor score and total TEI score were negatively correlated with regional MDDS in the vicinity of the right putamen and right pallidum and that TEI intrapersonal factor score was negatively correlated with MD values of the fusiform gyrus. Total TEI score and TEI factor scores were positively correlated with MD values of various areas within or adjacent to SCN components, SMC structures and the lateral prefrontal cortex (LPFC). Our MD findings demonstrated the importance of the dopaminergic system to TEI and implicate the SCN, SMC and LPFC in TEI. Future studies are required to investigate the implications of positive and negative associations with MD values.
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International-journal Peer-reviewed

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　2019/08/25

DOI： 10.1093/ije/dyz169 　

ISSN： 0300-5771
Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　9　(1)　12227-12227　2019/08/22

DOI： 10.1038/s41598-019-48654-8 　

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Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. "What, will these hands ne'er be clean?" William Shakespeare (Shakespeare, 1606) Macbeth.
Diversity of ATM gene variants: a population-based genome data analysis for precision medicine. International-journal International-coauthorship Peer-reviewed

Fukunaga H, Taki Y, Prise KM

Human Genomics　13　(1)　38　2019/08

DOI： 10.1186/s40246-019-0234-2 　

ISSN： 1473-9542
A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Cerebral cortex (New York, N.Y. : 1991)　29　(8)　3211-3219　2019/07/22

DOI： 10.1093/cercor/bhy189 　

ISSN： 1047-3211

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Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. Here we investigated the sex-specific effects of the CACNA1C variant rs1024582 on psychiatry-related traits, brain activity during tasks and rest, and brain volume in 1207 normal male and female subjects. After correcting for multiple comparisons, there were significant interaction effects between sex and the minor allele of this polymorphism on the hostile behavior subscale scores of the Coronary-Prone Type Scale mediated by higher scores in female carriers of the minor allele. Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain activity during the 2-back task in areas of the right posterior cingulate cortex, right thalamus, and right hippocampus, which were all mediated by reduced activity in female carriers of the minor allele. Our results demonstrated that the rs1024582 risk variant of CACNA1C is associated with reduced activity in the frontolimbic regions at rest and during a working memory task as well as with greater hostility in females in the healthy population.
Detecting glaucomatous change with magnetic resonance imaging of the brain primary visual cortex

Akio Yamada, Kazuko Omodaka, Yasuko Tatewaki, Noriko Himori, Izumi Matsudaira, Taki Yasuyuki, Toru Nakazawa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE　60　(9)　2019/07

ISSN： 0146-0404

eISSN： 1552-5783
Empathizing associates with mean diffusivity. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　9　(1)　8856-8856　2019/06/20

DOI： 10.1038/s41598-019-45106-1 　

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Empathizing is defined as "the drive to identify another's mental states and to respond to these with an appropriate emotion" and systemizing is defined as "the drive to the drive to analyze and construct rule-based systems". While mean diffusivity (MD) has been robustly associated with several cognitive traits and disorders related with empathizing and systemizing, its direct correlation with empathizing and systemizing remains to be investigated. We undertook voxel-by-voxel investigations of regional MD to discover microstructural correlates of empathizing, systemizing, and the discrepancy between them (D score: systemizing - empathizing). Whole-brain analyses of covariance revealed that across both sexes, empathizing was positively correlated with MD of (a) an anatomical cluster that primarily spreads in the areas in and adjacent to the left dorsolateral prefrontal cortex, left anterior to the middle cingulate cortex, and left insula and (b) an anatomical cluster of the left postcentral gyrus and left rolandic operculum. The former overlaps with positive MD correlates of cooperativeness. The D score and systemizing did not show significant correlations. In conclusion, while increased MD has generally been associated with reduced neural tissues and possibly area function, higher empathizing and cooperativeness were commonly reflected by greater MD values in areas (a) that mainly overlap with areas that play a key role in emotional salience and empathy. In addition, higher empathizing was correlated with greater MD values in areas (b) that play a key role in the mirror neuron system.
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
高齢者の重症大動脈弁狭窄症患者に対する経カテーテル大動脈弁置換術は脳血流量と認知機能を改善する

土屋聡, 松本泰治, 鈴木秀明, 竹内雅史, 菊地翼, 高橋潤, 冨田尚希, 瀧靖之, 荒井啓行, 下川宏明

日本老年医学会雑誌　56　(Suppl.)　144-144　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
高齢者の急性脳梗塞に対する積極的治癒の適応と予後に関する検討

山本修三, 武藤達士, 鶴谷尚信, 渡部憲明, 米谷元裕, 高野由美, 冲永壯治, 安井信之, 荒井啓行, 瀧靖之

日本老年医学会雑誌　56　(Suppl.)　153-153　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
高齢者の慢性硬膜下血腫に対する外科治療と予後新定義案に基づいた年齢別検討

山本修三, 武藤達士, 渡部憲昭, 鶴谷尚信, 高野由美, 舘脇康子, 米谷元裕, 安井信之, 荒井啓行, 瀧靖之

日本老年医学会雑誌　56　(Suppl.)　167-168　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
アルツハイマー型認知症に関わる脳領域の灰白質体積と骨密度の相関 Bone-brain crosstalkの画像医学的検証

高野由美, 舘脇康子, 武藤達士, 山本修三, 諸田直哉, 松平泉, 小田桐逸人, 冲永壯治, 荒井啓行, 瀧靖之

日本老年医学会雑誌　56　(Suppl.)　170-170　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
教育年数と高齢期抑うつ傾向後方視的研究 Peer-reviewed

國時景子, 舘脇康子, 高野由美, 石木愛子, 冨田尚希, 沼崎宗夫, 冲永壯治, 武藤達士, 荒井啓行, 瀧靖之

日本老年医学会雑誌　56　(Suppl.)　181-181　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Effect of hippotherapy on gait symmetry in children with cerebral palsy: A pilot study

Tomoko Mutoh, Tatsushi Mutoh, Hirokazu Tsubone, Makoto Takada, Misato Doumura, Masayo Ihara, Hideo Shimomura, Yasuyuki Taki, Masahiro Ihara

Clinical and Experimental Pharmacology and Physiology　46　(5)　506-509　2019/05

DOI： 10.1111/1440-1681.13076 　

ISSN： 0305-1870

eISSN： 1440-1681
An age estimation method using 3d-cnn from brain MRI images

Masaru Ueda, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

Proceedings - International Symposium on Biomedical Imaging　2019-April　380-383　2019/04

DOI： 10.1109/ISBI.2019.8759392 　

ISSN： 1945-7928

eISSN： 1945-8452
Precision Radiotherapy and Radiation Risk Assessment: How Do We Overcome Radiogenomic Diversity? International-journal International-coauthorship Peer-reviewed

Fukunaga H, Yokoya A, Taki Y, Butterworth KT, Prise KM

The Tohoku Journal of Experimental Medicine　247　(4)　223-235　2019/04
Publisher: Tohoku University
DOI： 10.1620/tjem.247.223 　

ISSN： 0040-8727
Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Brain structure & function　224　(3)　1203-1217　2019/04

DOI： 10.1007/s00429-019-01830-y 　

ISSN： 1863-2653

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Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper's complex roles in neural mechanisms.
Neural substrates of self- and external-preoccupation: A voxel-based morphometry study. International-journal Peer-reviewed

Ikeda S, Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Nakagawa S, Sekiguchi A, Iizuka K, Hanawa S, Araki T, Miyauchi CM, Sakaki K, Nozawa T, Yokota S, Magistro D, Kawashima R

Brain and behavior　9　(6)　e01267　2019/04

DOI： 10.1002/brb3.1267 　

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INTRODUCTION: Self- and external-preoccupation have been linked to psychopathological states. The neural substrates underlying self- and external-preoccupation remain unclear. In the present study, we aim to provide insight into the information-processing mechanisms associated with self- and external-preoccupation at the structural level. METHODS: To investigate the neural substrates of self- and external-preoccupation, we acquired high-resolution T1-weighted structural images and Preoccupation Scale scores from 1,122 young subjects. Associations between regional gray matter volume (rGMV) and Preoccupation Scale subscores for self- and external-preoccupation were estimated using voxel-based morphometry. RESULTS: Significant positive associations between self-preoccupation and rGMV were observed in widespread brain areas such as the bilateral precuneus and posterior cingulate gyri, structures known to be associated with self-triggered self-reference during rest. Significant negative associations between external-preoccupation and rGMV were observed only in the bilateral cerebellum, regions known to be associated with behavioral addiction, sustained attention, and reward system. CONCLUSION: Our results reveal distinct neural substrates for self- and external-preoccupation at the structural level.
【超高齢期の認知症を考える】超高齢期に発症する認知症と神経画像医学

舘脇康子, 瀧靖之

老年精神医学雑誌　30　(3)　255-263　2019/03
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
MRIを用いた脳一次視覚野の部位別の緑内障性変化の検出

山田晃生, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　123　(臨増)　222-222　2019/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
将来の心不全症状増悪に関連する脳領域(Brain Areas Associated with Future Exacerbation of Heart Failure Symptoms)

鈴木秀明, 松本泰治, 杉村宏一郎, 高橋潤, 宮田敏, 福本義弘, 瀧靖之, 下川宏明

日本循環器学会学術集会抄録集　83回　OJ04-6　2019/03
Publisher: (一社)日本循環器学会
Mean diffusivity related to collectivism among university students in Japan. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　9　(1)　1338-1338　2019/02/04

DOI： 10.1038/s41598-018-37995-5 　

ISSN： 2045-2322
くも膜下出血モデルにおけるmTOR経路を介した早期脳損傷の抑制効果の検証

佐々木一益, 武藤達士, 水流功春, 瀧靖之, Suarez Jose, 石川達哉

脳血管攣縮　34　52-52　2019/02
Publisher: スパズム・シンポジウム事務局
ISSN： 0912-7070
Positron emission tomography/computed tomography as a clinical diagnostic tool for anterior mediastinal tumors Peer-reviewed

Tatsuaki Watanabe, Hideo Shimomura, Tatsushi Mutoh, Ryoko Saito, Ryoi Goto, Takehiro Yamada, Hirotsugu Notsuda, Yasushi Matsuda, Masafumi Noda, Akira Sakurada, Yasuyuki Taki, Yoshinori Okada

Surgery Today　49　(2)　143-149　2019/02/01

DOI： 10.1007/s00595-018-1712-1 　

ISSN： 0941-1291

eISSN： 1436-2813
Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain imaging and behavior　2019/01/07

DOI： 10.1007/s11682-018-0025-8 　

ISSN： 1931-7557

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Numerous studies have reported that the Met allele of the brain-derived neurotrophic factor (BDNF) gene polymorphism reduces neural plasticity. A reduction in mean diffusivity (MD) in diffusion tensor imaging (DTI) characteristically reflects the neural plasticity that involves increased tissue components. In this study, we revealed that the number of Met-BDNF alleles was negatively associated with MD throughout the whole-brain gray and white matter areas of 743 subjects using DTI and whole-brain multiple regression analyses. Within the same sample, the region of interest analysis revealed that the number of Met-BDNF alleles significantly and positively correlated with the mean FA value in the body of the corpus callosum. In addition, we observed interaction effects between BDNF Val66Met polymorphism and daily physical activity levels on MD, but not FA, in significant clusters of the bilateral hemisphere (n = 577 subjects). Post-hoc multiple regression analyses revealed that after correcting for confounding variables, there was a significant negative correlation between the physical activity level and mean MD of the whole brain in the Val/Val group [standardized partial regression coefficient (β) = -0.196, P = 0.005, t = -2.825], but not in the Val/Met (β = 0.050, P = 0.412, t = 0.822) and Met/Met groups (β = 0.092, P = 0.382, t = 0.878). These results underscore the importance of the interaction between physical activity and the BDNF Val66Met polymorphism, which affects the plasticity of neural mechanisms.
An Age Estimation Method Using 3D-CNN From Brain MRI Images.

Masaru Ueda, Koichi Ito, Kai Wu 0002, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

16th IEEE International Symposium on Biomedical Imaging(ISBI)　380-383　2019
Publisher: IEEE
DOI： 10.1109/ISBI.2019.8759392 　
Longitudinal changes in ¹⁸F-THK5351 positron emission tomography in corticobasal syndrome

M. Ezura, A. Kikuchi, A. Ishiki, N. Okamura, T. Hasegawa, R. Harada, S. Watanuki, Y. Funaki, K. Hiraoka, T. Baba, N. Sugeno, R. Oshima, S. Yoshida, J. Kobayashi, M. Kobayashi, O. Tano, I. Nakashima, S. Mugikura, R. Iwata, Y. Taki, K. Furukawa, H. Arai, S. Furumoto, M. Tashiro, K. Yanai, Y. Kudo, A. Takeda, M. Aoki

European Journal of Neurology　26　(9)　1205-1211　2019

DOI： 10.1111/ene.13966 　

ISSN： 1351-5101

eISSN： 1468-1331
Arterial spin labeling magnetic resonance imaging in the assessment of non-convulsive status epilepticus in alzheimer’s disease: A report of two cases Peer-reviewed

Tatsushi Mutoh, Kaoru Eguchi, Shuzo Yamamoto, Nobuyuki Yasui, Yasuyuki Taki

American Journal of Case Reports　20　1883-1887　2019

DOI： 10.12659/AJCR.919938 　

eISSN： 1941-5923
Central action of rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage Peer-reviewed

Shuzo Yamamoto, Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Yasuyuki Taki

Brain Research Bulletin　144　85-91　2019/01

DOI： 10.1016/j.brainresbull.2018.11.015 　

ISSN： 0361-9230

eISSN： 1873-2747
Impact of Long-Term Hippotherapy on the Walking Ability of Children With Cerebral Palsy and Quality of Life of Their Caregivers. Peer-reviewed

Mutoh T, Mutoh T, Tsubone H, Takada M, Doumura M, Ihara M, Shimomura H, Taki Y, Ihara M

Frontiers in neurology　10　834　2019

DOI： 10.3389/fneur.2019.00834 　
Identification of non-convulsive status epilepticus with bradylalia using arterial spin-labeling magnetic resonance imaging. Peer-reviewed

Yamamoto S, Mutoh T, Tatewaki Y, Tsurutani H, Watabe N, Saito H, Yasui N, Taki Y

Acute medicine & surgery　6　(1)　73-77　2019/01

DOI： 10.1002/ams2.369 　

ISSN： 2052-8817
A single nucleotide polymorphism (-250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow Peer-reviewed

Takahashi Y, Takeuchi H, Sakai M, Yu Z, Kikuchi Y, Ito F, Matsuoka H, Yasuda J, Taki Y, Kawashima R, Tomita H

Psychiatry and Clinical Neurosciences　in press　2019
rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents. Peer-reviewed

Matsudaira I, Oba K, Takeuchi H, Sekiguchi A, Tomita H, Taki Y, Kawashima R

PloS one　14　(8)　e0221768-e0221768　2019
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0221768 　

eISSN： 1932-6203
Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage Peer-reviewed

Shuzo Yamamoto, Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Yasuko Tatewaki, Yasuyuki Taki

Clinical and Experimental Pharmacology and Physiology　46　(1)　99-102　2019/01

DOI： 10.1111/1440-1681.13035 　

ISSN： 0305-1870

eISSN： 1440-1681
健常人におけるドーパミントランスポーター密度の性差加齢変化 voxel baseでの検討 Peer-reviewed

高野晴成, 斎藤友美, 小川雅代, 松田博史, 佐光一也, 永山寛, 瀧靖之, 平野成樹, 小野賢二郎, 外山宏, 河野淳, 村田美穂

核医学　55　(1)　26-26　2018/12
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
General intelligence is associated with working memory-related brain activity: new evidence from a large sample study. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Brain structure & function　223　(9)　4243-4258　2018/12

DOI： 10.1007/s00429-018-1747-5 　

ISSN： 1863-2653

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Psychometric intelligence is closely related to working memory capacity. Here we aim to determine the associations of neural activation patterns during the N-back working memory paradigm with psychometric intelligence and working memory performance. We solved the statistical problems of previous studies using (1) a large cohort of 1235 young adults and (2) robust voxel-by-voxel permutation-based statistics at the whole-brain level. Many of the significant correlations were weak, and our findings were not consistent with those of previous studies. We observed that many of the significant correlations involved brain areas in the periphery or boundaries between the task-positive network (TPN) and task-negative network (TNN), suggesting that the expansion of the TPN or TNN is associated with greater cognitive ability. Lower activity in TPN and less task-induced deactivation (TID) in TNN were associated with greater cognitive ability. These findings indicate that subjects with greater cognitive ability have a lower brain response to task demand, consistent with the notion that TID in TNN reflects cognitive demand but partly inconsistent with the prevailing neural efficiency theory. One exception was the pre-supplementary motor area, which plays a key role in cognitive control and sequential processing. In this area, intelligent subjects demonstrated greater activity related to working memory, suggesting that the pre-supplementary motor area plays a unique role in the execution of working memory tasks in intelligent subjects.
Isolated Fornix Infarction with Damage to the Limbic System as a Cause of Persistent Amnesia: A Case Report. International-journal Peer-reviewed

Yumi Takano, Yasuko Tatewaki, Tatsushi Mutoh, Yamato Ohara, Shuzo Yamamoto, Yasuyuki Taki

The American journal of case reports　19　1382-1385　2018/11/21

DOI： 10.12659/AJCR.912508 　

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BACKGROUND The fornix is a white matter tract bundle that acts as the major output of the hippocampus and is an important component of the Papez circuit. We present an instructive imaging case of sudden onset of persistent amnesia due to selective ischemic damage of the anterior fornix. CASE REPORT A 54-year-old Japanese male came to our attention for a sudden onset of retrograde amnesia, associated with severe anterograde amnesia. The brain magnetic resonance imaging demonstrated a bright diffusion restriction, which was associated with swollen fornices bilaterally. His symptoms gradually improved, but episodic memory impairment still persisted after 1 month. The coronal T1-weighted MPRAGE (magnetization-prepared rapid acquisition with gradient echo) sequence clearly showed disruption of the left anterior fornix. Diffusion tensor tracking showed decrease in the density of entire fiber tracts on the Papez circuit as well as location of the left fornix. CONCLUSIONS When dealing with sudden, persistent amnesia associated with small fornix infarction, it is prudent to consider the possibility of tract damage along with limbic system damage using MPRAGE sequence.
Genome analyses for the Tohoku Medical Megabank Project toward establishment of personalized healthcare. Peer-reviewed

Yasuda J, Kinoshita K, Katsuoka F, Danjoh I, Sakurai-Yageta M, Motoike IN, Kuroki Y, Saito S, Kojima K, Shirota M, Saigusa D, Otsuki A, Kawashima J, Yamaguchi-Kabata Y, Tadaka S, Aoki Y, Mimori T, Kumada K, Inoue J, Makino S, Kuriki M, Fuse N, Koshiba S, Tanabe O, Nagasaki M, Tamiya G, Shimizu R, Takai-Igarashi T, Ogishima S, Hozawa A, Kuriyama S, Sugawara J, Tsuboi A, Kiyomoto H, Ishii T, Tomita H, Minegishi N, Suzuki Y, Suzuki K, Kawame H, Tanaka H, Taki Y, Yaegashi N, Kure S, Nagami F, Tohoku Medical Megabank Project, Study Group, Kosaki K, Sutoh Y, Hachiya T, Shimizu A, Sasaki M, Yamamoto M

Journal of biochemistry　165　(2)　139-158　2018/11

DOI： 10.1093/jb/mvy096 　

ISSN： 0021-924X

eISSN： 1756-2651
Impact of frequency of internet use on development of brain structures and verbal intelligence: Longitudinal analyses. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

Human brain mapping　39　(11)　4471-4479　2018/11

DOI： 10.1002/hbm.24286 　

ISSN： 1065-9471

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Excessive internet use is shown to be cross sectionally associated with lower cognitive functioning and reduced volume of several brain areas. However, the effects of daily internet use on the development of verbal intelligence and brain structures have not been investigated. Here, we cross sectionally examined the effects of the frequency of internet use on regional gray/white matter volume (rGMV/rWMV) and verbal intelligence as well as their longitudinal changes after 3.0 ± 0.3 (standard deviation) years in a large sample of children recruited from the general population (mean age, 11.2 ± 3.1 years; range, 5.7-18.4 years). Although there were no significant associations in cross sectional analyses, a higher frequency of internet use was found to be associated with decrease of verbal intelligence and smaller increase in rGMV and rWMV of widespread brain areas after a few years in longitudinal analyses. These areas involve areas related to language processing, attention and executive functions, emotion, and reward. In conclusion, frequent internet use is directly or indirectly associated with decrease of verbal intelligence and development to smaller gray matter volume at later stages.
Performance Evaluation of Age Estimation from T1-Weighted Images Using Brain Local Features and CNN

Koichi Ito, Ryuichi Fujimoto, Tzu Wei Huang, Hwann Tzong Chen, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2018-July　694-697　2018/10/26

DOI： 10.1109/EMBC.2018.8512443 　

ISSN： 1557-170X
非痙攣性てんかん重積の早期診断にArterial spin-labeling(ASL)によるMRI灌流画像が有用であった1例

山本修三, 武藤達士, 鶴谷尚信, 渡部憲明, 米谷元裕, 瀧靖之, 安井信之

日本救急医学会雑誌　29　(10)　589-589　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
【認知症トータルケア】正常加齢変化(MRI)

舘脇康子, 瀧靖之

日本医師会雑誌　147　(特別2)　S2-S3　2018/10
Publisher: (公社)日本医師会
ISSN： 0021-4493
Comparison of Noninvasive Dynamic Indices of Fluid Responsiveness Among Different Ventilation Modes in Dogs Recovering from Experimental Cardiac Surgery. Peer-reviewed

Sasaki K, Mutoh T, Yamamoto S, Taki Y, Kawashima R

Medical science monitor : international medical journal of experimental and clinical research　24　7736-7741　2018/10

DOI： 10.12659/MSM.910135 　

ISSN： 1234-1010
Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

DOI： 10.1620/tjem.246.97 　

ISSN： 0040-8727

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Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.
認知症診断におけるアミロイド PADREおよびPiBの整合性の初期検討

戸恒智子, 舘脇康子, 石木愛子, 米田哲也, 明石敏昭, 永坂竜男, 高野由美, 荒井啓行, 瀧靖之

Dementia Japan　32　(3)　470-470　2018/09
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
慢性硬膜下血腫に対する漢方薬の有効性再発と予後に関する検証

山本修三, 武藤達士, 鶴谷尚信, 渡部憲明, 米谷元祐, 荒井啓行, 瀧靖之, 安井信之

Dementia Japan　32　(3)　499-499　2018/09
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
アルツハイマー型認知症に関わる脳領域の灰白質体積と骨密度の相関

諸田直哉, 舘脇康子, 松平泉, 高野由美, 國時景子, 戸恒智子, 山本修三, 武藤達士, 荒井啓行, 瀧靖之

日本骨粗鬆症学会雑誌　4　(Suppl.1)　391-391　2018/09
Publisher: (一社)日本骨粗鬆症学会
ISSN： 2189-8383
Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage. Peer-reviewed

Sasaki K, Yamamoto S, Mutoh T, Tsuru Y, Taki Y, Kawashima R

Clinical and experimental pharmacology & physiology　45　(8)　859-862　2018/08

DOI： 10.1111/1440-1681.12950 　

ISSN： 0305-1870
Performance Evaluation of Age Estimation from T1-Weighted Images Using Brain Local Features and CNN. International-journal

Koichi Ito, Ryuichi Fujimoto, Tzu-Wei Huang, Hwann-Tzong Chen, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference　2018　694-697　2018/07

DOI： 10.1109/EMBC.2018.8512443 　

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The age of a subject can be estimated from the brain MR image by evaluating morphological changes in healthy aging. We consider using two-types of local features to estimate the age from T1-weighted images: handcrafted and automatically extracted features in this paper. The handcrafted brain local features are defined by volumes of brain tissues parcellated into 90 or 1,024 local regions defined by the automated anatomical labeling atlas. The automatically extracted features are obtained by using the convolutional neural network (CNN). This paper explores the difference between the handcrafted features and the automatically extracted features. Through a set of experiments using 1,099 T1-weighted images from a Japanese MR image database, we demonstrate the effectiveness of the proposed methods, analyze the effectiveness of each local region for age estimation and discuss its medical implication.
Japanese multicenter database of healthy controls for [123I]FP-CIT SPECT. International-journal Peer-reviewed

Hiroshi Matsuda, Miho Murata, Yohei Mukai, Kazuya Sako, Hidetoshi Ono, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hideo Shimomura, Hiroshi Nagayama, Amane Tateno, Kenjiro Ono, Hidetomo Murakami, Atsushi Kono, Shigeki Hirano, Satoshi Kuwabara, Norihide Maikusa, Masayo Ogawa, Etsuko Imabayashi, Noriko Sato, Harumasa Takano, Jun Hatazawa, Ryosuke Takahashi

European journal of nuclear medicine and molecular imaging　45　(8)　1405-1416　2018/07

DOI： 10.1007/s00259-018-3976-5 　

ISSN： 1619-7070

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PURPOSE: The aim of this multicenter trial was to generate a [123I]FP-CIT SPECT database of healthy controls from the common SPECT systems available in Japan. METHODS: This study included 510 sets of SPECT data from 256 healthy controls (116 men and 140 women; age range, 30-83 years) acquired from eight different centers. Images were reconstructed without attenuation or scatter correction (NOACNOSC), with only attenuation correction using the Chang method (ChangACNOSC) or X-ray CT (CTACNOSC), and with both scatter and attenuation correction using the Chang method (ChangACSC) or X-ray CT (CTACSC). These SPECT images were analyzed using the Southampton method. The outcome measure was the specific binding ratio (SBR) in the striatum. These striatal SBRs were calibrated from prior experiments using a striatal phantom. RESULTS: The original SBRs gradually decreased in the order of ChangACSC, CTACSC, ChangACNOSC, CTACNOSC, and NOACNOSC. The SBRs for NOACNOSC were 46% lower than those for ChangACSC. In contrast, the calibrated SBRs were almost equal under no scatter correction (NOSC) conditions. A significant effect of age was found, with an SBR decline rate of 6.3% per decade. In the 30-39 age group, SBRs were 12.2% higher in women than in men, but this increase declined with age and was absent in the 70-79 age group. CONCLUSIONS: This study provided a large-scale quantitative database of [123I]FP-CIT SPECT scans from different scanners in healthy controls across a wide age range and with balanced sex representation. The phantom calibration effectively harmonizes SPECT data from different SPECT systems under NOSC conditions. The data collected in this study may serve as a reference database.
Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain Peer-reviewed

Mai Sakai, Hikaru Takeuchi, Zhiqian Yu, Yoshie Kikuchi, Chiaki Ono, Yuta Takahashi, Fumiaki Ito, Hiroo Matsuoka, Osamu Tanabe, Jun Yasuda, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

Psychiatry and Clinical Neurosciences　72　(6)　409-422　2018/06/01
Publisher: Blackwell Publishing
DOI： 10.1111/pcn.12649 　

ISSN： 1440-1819 1323-1316

eISSN： 1440-1819
一般内科医における骨粗鬆症の診断能向上のために SQ法とDXA法の比較検討

國時景子, 舘脇康子, 中川学, 高野由美, 戸恒智子, 武藤達士, 荒井啓行, 瀧靖之

日本老年医学会雑誌　55　(Suppl.)　160-160　2018/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure. International-journal Peer-reviewed

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

European journal of heart failure　20　(5)　936-938　2018/05

DOI： 10.1002/ejhf.1104 　

ISSN： 1388-9842
Utility of electrical velocimetry-based noninvasive stroke volume variation in predicting fluid responsiveness under different ventilation modes in anaesthetized dogs. Peer-reviewed

Sasaki K, Mutoh T, Yamamoto S, Taki Y, Kawashima R

Clinical and experimental pharmacology & physiology　2018/05

DOI： 10.1111/1440-1681.12968 　

ISSN： 0305-1870
Shorter sleep duration and better sleep quality are associated with greater tissue density in the brain. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Scientific reports　8　(1)　5833-5833　2018/04/11

DOI： 10.1038/s41598-018-24226-0 　

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Poor sleep quality is associated with unfavorable psychological measurements, whereas sleep duration has complex relationships with such measurements. The aim of this study was to identify the associations between microstructural properties of the brain and sleep duration/sleep quality in a young adult. The associations between mean diffusivity (MD), a measure of diffusion tensor imaging (DTI), and sleep duration/sleep quality were investigated in a study cohort of 1201 normal young adults. Positive correlations between sleep duration and MD of widespread areas of the brain, including the prefrontal cortex (PFC) and the dopaminergic systems, were identified. Negative correlations between sleep quality and MD of the widespread areas of the brain, including the PFC and the right hippocampus, were also detected. Lower MD has been previously associated with more neural tissues in the brain. Further, shorter sleep duration was associated with greater persistence and executive functioning (lower Stroop interference), whereas good sleep quality was associated with states and traits relevant to positive affects. These results suggest that bad sleep quality and longer sleep duration were associated with aberrant neurocognitive measurements in the brain in healthy young adults.
REDUCED FUNCTIONAL CONNECTIVITY BETWEEN THE RIGHT VENTRAL ACC AND MFG PREDICTS PTSD SYMPTOMS AFTER A DISASTER Peer-reviewed

Sekiguchi Atsushi, Kotozaki Yuka, Sugiura Motoaki, Nakagawa Seishu, Nouchi Rui, Miyauchi Carlos M, Takeuchi Hikaru, Taki Yasuyuki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　80　(3)　A72-A73　2018/04

ISSN： 0033-3174
Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage Peer-reviewed

Tatsushi Mutoh, Kazumasu Sasaki, Yasuko Tatewaki, Keiko Kunitoki, Yumi Takano, Yasuyuki Taki

Clinical and Experimental Pharmacology and Physiology　45　(4)　344-348　2018/04/01
Publisher: Blackwell Publishing
DOI： 10.1111/1440-1681.12874 　

ISSN： 1440-1681 0305-1870
A case of low-grade primary cardiac lymphoma with pericardial effusion diagnosed by combined18F-fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) imaging and effusion cytology Peer-reviewed

Hisanori Fukunaga, Yasuko Tatewaki, Tatsushi Mutoh, Hideo Shimomura, Shuzo Yamamoto, Chiaki Terao, Tomoko Totsune, Manabu Nakagawa, Yasuyuki Taki

American Journal of Case Reports　19　292-295　2018/03/14
Publisher: International Scientific Information, Inc.
DOI： 10.12659/AJCR.908385 　

ISSN： 1941-5923
Allergic tendencies are associated with larger gray matter volumes. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

Scientific reports　8　(1)　3694-3694　2018/02/27

DOI： 10.1038/s41598-018-21985-8 　

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Allergic tendencies are associated with important cognitive and physiological factors, such as intelligence and mathematical abilities. Allergies are widely prevalent, especially in modern life, and the reason for its association with important cognitive variables is an intriguing scientific question. However, despite the unique characteristics of cognitive correlates of allergy, the anatomical correlates of allergy remain unknown. The aim of this study was to identify the associations between regional gray matter volume (rGMV) and allergic tendencies in young adults. In a study cohort of 1,219 healthy, educated young adults, we identified a positive correlation between total allergic tendency and rGMV in large anatomical clusters that mainly encompassed the dorsal part of the cerebral neocortex, right anterior insula, and cerebellum. Furthermore,both mean rGMV of the entire part of these clusters and total allergenic tendency showed a significant positive correlation with spatial ability. These results suggest the link among allergic tendencies, larger rGMV, and the better spatial ability in healthy, educated young adults.
Posterior associative and cingulate cortex involvement of brain single-photon emission computed tomography (Spect) imaging in semantic dementia with probable alzheimer disease pathology: A case report Peer-reviewed

Yumi Takano, Keiko Kunitoki, Yasuko Tatewaki, Tatsushi Mutoh, Tomoko Totsune, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki

American Journal of Case Reports　19　153-157　2018/02/12
Publisher: International Scientific Information, Inc.
DOI： 10.12659/AJCR.907799 　

ISSN： 1941-5923
くも膜下出血の循環管理における低侵襲連続心拍出量モニターの有用性

武藤達士, 石川達哉, 瀧靖之

脳血管攣縮　33　62-62　2018/02
Publisher: スパズム・シンポジウム事務局
ISSN： 0912-7070
肺癌SRT症例の治療前PETにおけるテクスチャ解析の有用性

武田一也, 松下晴雄, 久保園正樹, 田邊隆哉, 石川陽二郎, 山本貴也, 古積麻衣子, 高橋紀善, 片桐佑, 田坂俊, 福井勝哉, 鈴木友, 角谷倫之, 伊藤謙吾, 千葉瑞己, 神宮啓一, 武田賢, 土橋卓, 高浪健太郎, 高瀬圭, 瀧靖之

Japanese Journal of Radiology　36　11-11　2018/02
Reduced CBF recovery detected by longitudinal 3D-SSP SPECT analyses predicts outcome of postoperative patients after subarachnoid haemorrhage Peer-reviewed

Tatsushi Mutoh, Tomoko Totsune, Shunsuke Takenaka, Yasuko Tatewaki, Manabu Nakagawa, Jose I Suarez, Yasuyuki Taki, Tatsuya Ishikawa

Clinical and Experimental Pharmacology and Physiology　45　(2)　127-132　2018/02/01
Publisher: Blackwell Publishing
DOI： 10.1111/1440-1681.12867 　

ISSN： 1440-1681 0305-1870
18-Fluorodeoxyglucose Positron Emission Tomography Predicts Recurrence in Resected Pancreatic Ductal Adenocarcinoma. International-journal Peer-reviewed

Kyohei Ariake, Fuyuhiko Motoi, Hideo Shimomura, Masamichi Mizuma, Shimpei Maeda, Chiaki Terao, Yasuko Tatewaki, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Tatsuyuki Takadate, Takeshi Naitoh, Yasuyuki Taki, Michiaki Unno

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract　22　(2)　279-287　2018/02

DOI： 10.1007/s11605-017-3627-3 　

ISSN： 1091-255X

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BACKGROUND: We aimed to determine whether treatment should be stratified according to 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake values (SUVmax) in pancreatic ductal adenocarcinoma. METHODS: Patients who underwent preoperative 18F-FDG PET/CT between 2006 and 2014 (n = 138) were stratified into high (≥ 4.85) and low (< 4.85) PET groups. The clinicopathological characteristics and prognostic outcomes were analyzed retrospectively. RESULTS: The primary tumor SUVmax was positively correlated with preoperative CA19-9 levels (P < 0.001). The high PET group failed to achieve postoperative CA19-9 normalization (P = 0.014). Disease-specific (P < 0.001), recurrence-free (P < 0.001), liver recurrence-free (P < 0.001), and peritoneal recurrence-free (P = 0.020) survivals were significantly shorter in the high PET group. The primary tumor SUVmax was an independent predictive risk factor for liver metastasis (hazard ratio 3.46, 95% confidence interval 1.61-7.87; P = 0.001) and peritoneal recurrence (hazard ratio 3.36, 95% confidence interval 1.18-10.89; P = 0.023). CONCLUSIONS: Surgical resection failed to achieve CA19-9 normalization in the high PET group and distant recurrence was frequent. This suggests the potential for residual cancer at distant sites, even after curative resection. Stronger preoperative systemic chemotherapy is preferred for the high PET group patients.
Impact of serial gait analyses on long-term outcome of hippotherapy in children and adolescents with cerebral palsy Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Hirokazu Tsubone, Makoto Takada, Misato Doumura, Masayo Ihara, Hideo Shimomura, Yasuyuki Taki, Masahiro Ihara

Complementary Therapies in Clinical Practice　30　19-23　2018/02/01
Publisher: Churchill Livingstone
DOI： 10.1016/j.ctcp.2017.11.003 　

ISSN： 1744-3881
Refractive error is associated with intracranial volume. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　8　(1)　175-175　2018/01/09

DOI： 10.1038/s41598-017-18669-0 　

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Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.
3D-CNNを用いた脳MRI画像からの年齢推定手法に関する検討

上田大, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電気関係学会東北支部連合大会講演論文集　2018　51-51　2018
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2018.0_51 　
Performance Evaluation of Age Estimation from T1-Weighted Images Using Brain Local Features and CNN.

Koichi Ito, Ryuichi Fujimoto, Tzu-Wei Huang, Hwann-Tzong Chen, Kai Wu 0002, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society(EMBC)　694-697　2018
Publisher: IEEE
DOI： 10.1109/EMBC.2018.8512443 　
The Effects of Family Socioeconomic Status on Psychological and Neural Mechanisms as Well as Their Sex Differences. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoishi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Frontiers in human neuroscience　12　543-543　2018

DOI： 10.3389/fnhum.2018.00543 　

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Family socioeconomic status (SES) is an important factor that affects an individual's neural and cognitive development. The two novel aims of this study were to reveal (a) the effects of family SES on mean diffusivity (MD) using diffusion tensor imaging given the characteristic property of MD to reflect neural plasticity and development and (b) the sex differences in SES effects. In a study cohort of 1,216 normal young adults, we failed to find significant main effects of family SES on MD; however, previously observed main effects of family SES on regional gray matter volume and fractional anisotropy (FA) were partly replicated. We found a significant effect of the interaction between sex and family income on MD in the thalamus as well as significant effects of the interaction between sex and parents' educational qualification (year's of education) on MD and FA in the body of the corpus callosum as well as white matter areas between the anterior cingulate cortex and lateral prefrontal cortex. These results suggest the sex-specific associations of family SES with neural and/or cognitive mechanisms particularly in neural tissues in brain areas that play key roles in basic information processing and higher-order cognitive processes in a way females with greater family SES level show imaging outcome measures that have been associated with more neural tissues (such as greater FA and lower MD) and males showed opposite.
Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development Peer-reviewed

Keisuke Wakusawa, Chieko Nara, Yuki Kubota, Yayoi Tomizawa, Yasuyuki Taki, Yuko Sassa, Satoru Kobayashi, Sato Suzuki-Muromoto, Mieko Hirose, Hiroyuki Yokoyama, Takahiro Nara, Shigeo Kure, Norio Mori, Noriyoshi Takei, Ryuta Kawashima

Brain and Development　40　(1)　16-25　2018/01/01

DOI： 10.1016/j.braindev.2017.07.002 　

ISSN： 1872-7131 0387-7604

eISSN： 1872-7131
Segmentation of the hippocampus by transferring algorithmic knowledge for large cohort processing. International-journal Peer-reviewed

Benjamin Thyreau, Kazunori Sato, Hiroshi Fukuda, Yasuyuki Taki

Medical image analysis　43　214-228　2018/01

DOI： 10.1016/j.media.2017.11.004 　

ISSN： 1361-8415

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The hippocampus is a particularly interesting target for neuroscience research studies due to its essential role within the human brain. In large human cohort studies, bilateral hippocampal structures are frequently identified and measured to gain insight into human behaviour or genomic variability in neuropsychiatric disorders of interest. Automatic segmentation is performed using various algorithms, with FreeSurfer being a popular option. In this manuscript, we present a method to segment the bilateral hippocampus using a deep-learned appearance model. Deep convolutional neural networks (ConvNets) have shown great success in recent years, due to their ability to learn meaningful features from a mass of training data. Our method relies on the following key novelties: (i) we use a wide and variable training set coming from multiple cohorts (ii) our training labels come in part from the output of the FreeSurfer algorithm, and (iii) we include synthetic data and use a powerful data augmentation scheme. Our method proves to be robust, and it has fast inference (<30s total per subject), with trained model available online (https://github.com/bthyreau/hippodeep). We depict illustrative results and show extensive qualitative and quantitative cohort-wide comparisons with FreeSurfer. Our work demonstrates that deep neural-network methods can easily encode, and even improve, existing anatomical knowledge, even when this knowledge exists in algorithmic form.
Effects of Time-Compressed Speech Training on Multiple Functional and Structural Neural Mechanisms Involving the Left Superior Temporal Gyrus. International-journal Peer-reviewed

Tsukasa Maruyama, Hikaru Takeuchi, Yasuyuki Taki, Kosuke Motoki, Hyeonjeong Jeong, Yuka Kotozaki, Seishu Nakagawa, Rui Nouchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Kohei Sakaki, Yukako Sasaki, Daniele Magistro, Ryuta Kawashima

Neural plasticity　2018　6574178-6574178　2018

DOI： 10.1155/2018/6574178 　

ISSN： 2090-5904

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Time-compressed speech is an artificial form of rapidly presented speech. Training with time-compressed speech (TCSSL) in a second language leads to adaptation toward TCSSL. Here, we newly investigated the effects of 4 weeks of training with TCSSL on diverse cognitive functions and neural systems using the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), resting-state functional connectivity (RSFC) with the left superior temporal gyrus (STG), fractional anisotropy (FA), and regional gray matter volume (rGMV) of young adults by magnetic resonance imaging. There were no significant differences in change of performance of measures of cognitive functions or second language skills after training with TCSSL compared with that of the active control group. However, compared with the active control group, training with TCSSL was associated with increased fALFF, RSFC, and FA and decreased rGMV involving areas in the left STG. These results lacked evidence of a far transfer effect of time-compressed speech training on a wide range of cognitive functions and second language skills in young adults. However, these results demonstrated effects of time-compressed speech training on gray and white matter structures as well as on resting-state intrinsic activity and connectivity involving the left STG, which plays a key role in listening comprehension.
Quantitative MRI evaluation of glaucomatous changes in the visual pathway. International-journal Peer-reviewed

Fukuda M, Omodaka K, Tatewaki Y, Himori N, Matsudaira I, Nishiguchi KM, Murata T, Taki Y, Nakazawa T

PloS one　13　(7)　e0197027　2018

DOI： 10.1371/journal.pone.0197027 　

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BACKGROUND: The aims of this study were to investigate glaucomatous morphological changes quantitatively in the visual cortex of the brain with voxel-based morphometry (VBM), a normalizing MRI technique, and to clarify the relationship between glaucomatous damage and regional changes in the visual cortex of patients with open-angle glaucoma (OAG). METHODS: Thirty-one patients with OAG (age: 55.9 ± 10.7, male: female = 9: 22) and 20 age-matched controls (age: 54.9 ± 9.8, male: female = 10: 10) were included in this study. The cross-sectional area (CSA) of the optic nerve was manually measured with T2-weighed MRI. Images of the visual cortex were acquired with T1-weighed 3D magnetization-prepared rapid acquisition with gradient echo (MPRAGE) sequencing, and the normalized regional visual cortex volume, i.e., gray matter density (GMD), in Brodmann areas (BA) 17, 18, and 19, was calculated with a normalizing technique based on statistic parametric mapping 8 (SPM8) analysis. We compared the regional GMD of the visual cortex in the control subjects and OAG patients. Spearman's rank correlation analysis was used to determine the relationship between optic nerve CSA and GMD in BA 17, 18, and 19. RESULTS: We found that the normal and OAG patients differed significantly in optic nerve CSA (p < 0.001) and visual cortex GMD in BA 17 (p = 0.030), BA 18 (p = 0.003), and BA 19 (p = 0.005). In addition, we found a significant correlation between optic nerve CSA and visual cortex GMD in BA 19 (r = 0.33, p = 0.023), but not in BA 17 (r = 0.17, p = 0.237) or BA 18 (r = 0.24, p = 0.099). CONCLUSION: Quantitative MRI parametric evaluation of GMD can detect glaucoma-associated anatomical atrophy of the visual cortex in BA 17, 18, and 19. Furthermore, GMD in BA 19 was significantly correlated to the damage level of the optic nerve, as well as the retina, in patients with OAG. This is the first demonstration of an association between the cortex of the brain responsible for higher-order visual function and glaucoma severity. Evaluation of the visual cortex with MRI is thus a very promising potential method for objective examination in OAG.
Brain maturation and aging: Large brain MRI database Peer-reviewed

Yasuyuki Taki

Memory in a Social Context: Brain, Mind, and Society　227-238　2017/12/15
Publisher: Springer Japan
DOI： 10.1007/978-4-431-56591-8_12 　
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI). International-journal Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

Medical science monitor : international medical journal of experimental and clinical research　23　5495-5503　2017/11/19

ISSN： 1234-1010

eISSN： 1643-3750

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BACKGROUND The optic radiation (OR) is a white-matter bundle connecting the lateral geniculate body and the visual cortex. Phase difference-enhanced imaging (PADRE) is a new MRI technique that is able to achieve precise delineation of the OR. The aim of this study was to investigate the effect of age on the volume and signal intensity of the OR using PADRE, and to establish a volumetric reference of the OR from a healthy population, compared with diffusion tensor imaging (DTI). MATERIAL AND METHODS Thirty-nine healthy volunteers underwent MR imaging with PADRE and DTI sequences on a 3.0-T scanner. For the volumetric analysis with PADRE, the OR corresponding to the external sagittal stratum was manually traced, while an automated thresholding method was used for the DTI-based volumetric analysis of the OR. RESULTS The mean right and left OR volumes measured from the PADRE images were 1469.0±242.4 mm³ and 1372.6±310.2 mm³, respectively. Although OR volume showed no significant correlation with age, the normalized OR signal intensity showed a linear correlation with increasing age (r²=0.50-0.53; P<0.01). The OR signal intensity on PADRE and DTI-related quantitative parameters for the OR showed significant correlations (r²=0.46-0.49; P<0.01). CONCLUSIONS The PADRE technique revealed exceptional preservation of OR volume, even in later life. Moreover, PADRE was able to detect age-related changes in signal intensity of the OR and may contribute to future analyses of pathological neurodegeneration in patients with glaucoma and multiple sclerosis.
Phase Difference-Enhanced Magnetic Resonance (MR) Imaging (PADRE) Technique for the Detection of Age-Related Microstructural Changes in Optic Radiation: Comparison with Diffusion Tensor Imaging (DTI) Peer-reviewed

Yasuko Tatewaki, Tatsushi Mutoh, Benjamin Thyreau, Kazuko Omodaka, Takaki Murata, Atsushi Sekiguchi, Toru Nakazawa, Yasuyuki Taki

MEDICAL SCIENCE MONITOR　23　5495-5503　2017/11

DOI： 10.12659/MSM.905571 　

ISSN： 1643-3750
Brain age estimation from T1-weighted images using effective local features Peer-reviewed

Ryuichi Fujimoto, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS　2017　3028-3031　2017/09/13
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/EMBC.2017.8037495 　

ISSN： 1557-170X
Lenticular nucleus correlates of general self-efficacy in young adults. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Brain structure & function　222　(7)　3309-3318　2017/09

DOI： 10.1007/s00429-017-1406-2 　

ISSN： 1863-2653

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General self-efficacy (GSE) is an important factor in education, social participation, and medical treatment. However, the only study that has investigated the direct association between GSE and a neural correlate did not identify specific brain regions, rather only assessed brain structures, and included older adult subjects. GSE is related to motivation, physical activity, learning, the willingness to initiate behaviour and expend effort, and adjustment. Thus, it was hypothesized in the present study that the neural correlates of GSE might be related to changes in the basal ganglia, which is a region related to the abovementioned self-efficacy factors. This study aimed to identify the brain structures associated with GSE in healthy young adults (n = 1204, 691 males and 513 females, age 20.7 ± 1.8 years) using regional grey matter density and volume (rGMD and rGMV), fractional anisotropy (FA) and mean diffusivity (MD) analyses of magnetic resonance imaging (MRI) data. The findings showed that scores on the GSE Scale (GSES) were associated with a lower MD value in regions from the right putamen to the globus pallidum; however, there were no significant association between GSES scores and regional brain structures using the other analyses (rGMD, rGMV, and FA). Thus, the present findings indicated that the lenticular nucleus is a neural correlate of GSE.
Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Scientific reports　7　(1)　10014-10014　2017/08/30

DOI： 10.1038/s41598-017-10104-8 　

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Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.
アルツハイマー病のための脳局所特徴量を用いたMR画像解析に関する検討

藤本竜一, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

日本医用画像工学会大会予稿集　36回　298-302　2017/07
Publisher: (一社)日本医用画像工学会
The VEGF gene polymorphism impacts brain volume and arterial blood volume. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Human brain mapping　38　(7)　3516-3526　2017/07

DOI： 10.1002/hbm.23606 　

ISSN： 1065-9471

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Vascular endothelial growth factor (VEGF) plays a critical role in the angiogenesis and proliferation of various types of cells such as neurons, astroglia, and endothelial cells in the brain. A common polymorphism in the VEGF gene (-2578 C/A) is associated with circulating VEGF levels, cancers and Alzheimer's disease. Nonetheless, the effects of this polymorphism on normal human brain volume, arterial blood volume, and blood supply remain unclear. In this study, the effects of this polymorphism on the total gray matter volume (TGMV) and total white matter volume (TWMV) using T1-weighted structural images and the total arterial blood volume (TABV) and mean cerebral blood flow (mCBF) during rest using arterial spin labeling (ASL) in 765 young adult humans were investigated. Voxel-by-voxel whole-brain analyses of these measures were also performed. Multiple regression analyses with age and sex as covariates revealed that the VEGF genotype (number of C alleles) was significantly and positively correlated with TGMV, TWMV, and TABV as well as with regional gray and white matter volumes in widespread areas and regional arterial blood volume in some areas with high arterial blood volume. However, these regional associations were not seen when the corresponding global signal was included as a covariate in the multiple regression analyses, indicating that we failed to obtain evidence of region-specific associations between these brain measures and the genotype. The results suggest that the VEGF-2578C allele, is associated with changes in the vascular system that lead to increased blood volume and larger brain volume. Hum Brain Mapp 38:3516-3526, 2017. © 2017 Wiley Periodicals, Inc.
MRI-based in vivo assessment of early cerebral infarction in a mouse filament perforation model of subarachnoid hemorrhage Peer-reviewed

Kazumasu Sasaki, Tatsushi Mutoh, Kazuhiro Nakamura, Ikuho Kojima, Yasuyuki Taki, Jose Ignacio Suarez, Tatsuya Ishikawa

NEUROSCIENCE LETTERS　653　173-176　2017/07

DOI： 10.1016/j.neulet.2017.05.047 　

ISSN： 0304-3940

eISSN： 1872-7972
Noninvasive stroke volume variation using electrical velocimetry for predicting fluid responsiveness in dogs undergoing cardiac surgery Peer-reviewed

Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Yasuyuki Taki, Ryuta Kawashima

Veterinary Anaesthesia and Analgesia　44　(4)　719-726　2017/07/01
Publisher: Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
DOI： 10.1016/j.vaa.2016.11.001 　

ISSN： 1467-2995 1467-2987
Understanding Medical Images Based on Computational Anatomy Models Peer-reviewed

Shouhei Hanaoka, Naoki Kamiya, Yoshinobu Sato, Kensaku Mori, Hiroshi Fukuda, Yasuyuki Taki, Kazunori Sato, Kai Wu, Yoshitaka Masutani, Takeshi Hara, Chisako Muramatsu, Akinobu Shimizu, Mikio Matsuhiro, Yoshiki Kawata, Noboru Niki, Daisuke Fukuoka, Tomoko Matsubara, Hidenobu Suzuki, Ryo Haraguchi, Toshizo Katsuda, Takayuki Kitasaka

Computational Anatomy Based on Whole Body Imaging: Basic Principles of Computer-Assisted Diagnosis and Therapy　151-284　2017/06/14
Publisher: Springer Japan
DOI： 10.1007/978-4-431-55976-4_3 　
グリア線維酸性蛋白質遺伝子多型の脳構造への影響の検討精神疾患感受性メカニズムの理解に向けて

高橋雄太, 伊藤文晃, 竹内光, 坂井舞, 兪志前, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2017特別号)　S622-S622　2017/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Regional homogeneity, resting-state functional connectivity and amplitude of low frequency fluctuation associated with creativity measured by divergent thinking in a sex-specific manner. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Yuko Sassa, Ryuta Kawashima

NeuroImage　152　258-269　2017/05/15

DOI： 10.1016/j.neuroimage.2017.02.079 　

ISSN： 1053-8119

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Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
Neural plasticity in amplitude of low frequency fluctuation, cortical hub construction, regional homogeneity resulting from working memory training. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Scientific reports　7　(1)　1470-1470　2017/05/03

DOI： 10.1038/s41598-017-01460-6 　

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Working memory training (WMT) induces changes in cognitive function and various neurological systems. Here, we investigated changes in recently developed resting state functional magnetic resonance imaging measures of global information processing [degree of the cortical hub, which may have a central role in information integration in the brain, degree centrality (DC)], the magnitude of intrinsic brain activity [fractional amplitude of low frequency fluctuation (fALFF)], and local connectivity (regional homogeneity) in young adults, who either underwent WMT or received no intervention for 4 weeks. Compared with no intervention, WMT increased DC in the anatomical cluster, including anterior cingulate cortex (ACC), to the medial prefrontal cortex (mPFC). Furthermore, WMT increased fALFF in the anatomical cluster including the right dorsolateral prefrontal cortex (DLPFC), frontopolar area and mPFC. WMT increased regional homogeneity in the anatomical cluster that spread from the precuneus to posterior cingulate cortex and posterior parietal cortex. These results suggest WMT-induced plasticity in spontaneous brain activity and global and local information processing in areas of the major networks of the brain during rest.
健常小児の脳の形態的発達

松平泉, 瀧靖之, 川島隆太

BRAIN and NERVE　69　(5)　539-545　2017/05
Neuro-myelomatosis of the brachial plexus – An unusual site of disease visualized by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT): A case report Peer-reviewed

Hisanori Fukunaga, Tatsushi Mutoh, Yasuko Tatewaki, Hideo Shimomura, Tomoko Totsune, Chiaki Terao, Hidemitsu Miyazawa, Yasuyuki Taki

American Journal of Case Reports　18　478-481　2017/05/01
Publisher: International Scientific Information, Inc.
DOI： 10.12659/AJCR.903761 　

ISSN： 1941-5923
Structural brain development in healthy children and adolescents Peer-reviewed

Izumi Matsudaira, Ryuta Kawashima, Yasuyuki Taki

Brain and Nerve　69　(5)　539-545　2017/05/01
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1416200780 　

ISSN： 1881-6096
Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure. Peer-reviewed

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Hiroyuki Arai, Yasuyuki Taki, Katsutoshi Furukawa, Yoshihiro Fukumoto, Hiroaki Shimokawa

Geriatrics & gerontology international　17　(5)　852-854　2017/05

DOI： 10.1111/ggi.12959 　

ISSN： 1444-1586
Radiobiological Implications of Fukushima Nuclear Accident for Personalized Medical Approach Peer-reviewed

Hisanori Fukunaga, Akinari Yokoya, Yasuyuki Taki, Kevin M. Prise

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　242　(1)　77-81　2017/05

DOI： 10.1620/tjem.242.77 　

ISSN： 0040-8727

eISSN： 1349-3329
Acute cardiac support with intravenous milrinone promotes recovery from early brain injury in a murine model of severe subarachnoid haemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazuhiro Nakamura, Yukiko Yamamoto, Yoshiharu Tsuru, Hirokazu Tsubone, Tatsuya Ishikawa, Yasuyuki Taki

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY　44　(4)　463-469　2017/04

DOI： 10.1111/1440-1681.12718 　

ISSN： 1440-1681
Acute cardiac support with intravenous milrinone promotes recovery from early brain injury in a murine model of severe subarachnoid haemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazuhiro Nakamura, Yukiko Yamamoto, Yoshiharu Tsuru, Hirokazu Tsubone, Tatsuya Ishikawa, Yasuyuki Taki

Clinical and Experimental Pharmacology and Physiology　44　(4)　463-469　2017/04/01
Publisher: Blackwell Publishing
DOI： 10.1111/1440-1681.12718 　

ISSN： 1440-1681 0305-1870
Inotropic support against early brain injury improves cerebral hypoperfusion and outcomes in a murine model of subarachnoid hemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazuhiro Nakamura, Kazumasu Sasaki, Yasuko Tatewaki, Tatsuya Ishikawa, Yasuyuki Taki

BRAIN RESEARCH BULLETIN　130　18-26　2017/04

DOI： 10.1016/j.brainresbull.2016.12.009 　

ISSN： 0361-9230

eISSN： 1873-2747
Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain structure & function　222　(2)　1027-1037　2017/03

DOI： 10.1007/s00429-016-1262-5 　

ISSN： 1863-2653

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Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.
Abstract WMP27: Cerebral Blood Velocity Changes During Dobutamine Administration for Experimental Subarachnoid Hemorrhage in Mice

Kazuhiro Nakamura, Tatsushi Mutoh, Kazumasu Sasaki, Yasuyuki Taki, Tatsuya Ishikawa

Stroke　48　(suppl_1)　2017/02
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI： 10.1161/str.48.suppl_1.wmp27 　

ISSN： 0039-2499

eISSN： 1524-4628

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<bold>Introduction:</bold> Hyperdynamic therapy with dobutamine (DOB) administration on patients with subarachnoid hemorrhage (SAH) is a useful strategy for treating cerebral vasospasm and neurological deterioration. Even some reports have suggested that DOB administration caused the cerebral blood flow (CBF) augmentation by increasing cardiac output, microcirculatory behavior in brain remains unclear. <bold>Hypothesis:</bold> Red blood cell (RBC) velocity should be increased under DOB administration. To investigate the cortical microcirculation, two-photon laser scanning microscopy with successive line-scans was used for red blood cell (RBC) velocity estimation. <bold>Methods:</bold> SAH was induced in ten male wild-type C57BL/6 mice (23 - 25g) using endovascular perforation technique. Five days after SAH, a cranial window was prepared for optical access to the cortical vasculature. Then we observed two-photon microscopy with intravenously injected rhodamine-dextran. The RBC velocity was visualized as dark objects against the fluorescent plasma background. The velocity was estimated from dark objects angle in successive line-scans analyzed by Radon function based algorithm. DOB was administrated intravenously at the dose of 6 and 12 μg/kg/min. <bold>Results:</bold> RBC velocity was increased in 8 mice after the DOB administration and 2 mice were reduced. The RBC velocity in increased mice of baseline , 6 , and 12 μg/kg/min was 1.29±0.40, 1.70±0.74 and 1.37±0.53 mm/sec, respectively. In the reduced mice, the RBC velocity was dropped almost half value of baseline at the DOB administration. <bold>Conclusions:</bold> DOB administration was increased RBC velocity in cortical microcirculation. It indicates DOB hyperdynamic therapy on patients with SAH is effective in the viewpoint of cortical microcirculatory control.
Neurocardiac protection with milrinone for restoring acute cerebral hypoperfusion and delayed ischemic injury after experimental subarachnoid hemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazumasu Sasaki, Kazuhiro Nakamura, Yasuko Tatewaki, Tatsuya Ishikawa, Yasuyuki Taki

NEUROSCIENCE LETTERS　640　70-75　2017/02

DOI： 10.1016/j.neulet.2017.01.008 　

ISSN： 0304-3940

eISSN： 1872-7972
Asymptomatic mild hyperperfusion for the prediction of clinical outcome in postoperative patients after subarachnoid hemorrhage Peer-reviewed

Manabu Nakagawa, Tatsushi Mutoh, Shunsuke Takenaka, Tomoko Mutoh, Tomoko Totsune, Yasuyuki Taki, Tatsuya Ishikawa

Medical Science Monitor　23　285-291　2017/01/17
Publisher: International Scientific Literature Inc.
DOI： 10.12659/MSM.899985 　

ISSN： 1643-3750 1234-1010
AGE ESTIMATION FROM BRAIN MRI IMAGES USING DEEP LEARNING Peer-reviewed

Tzu-Wei Huang, Hwann-Tzong Chen, Ryuichi Fujimoto, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017)　849-852　2017
Asymptomatic Mild Hyperperfusion for the Prediction of Clinical Outcome in Postoperative Patients After Subarachnoid Hemorrhage Peer-reviewed

Manabu Nakagawa, Tatsushi Mutoh, Shunsuke Takenaka, Tomoko Mutoh, Tomoko Totsune, Yasuyuki Taki, Tatsuya Ishikawa

MEDICAL SCIENCE MONITOR　23　285-291　2017/01

DOI： 10.12659/MSM.899985 　

ISSN： 1643-3750
The anterior midcingulate cortex as a neural node underlying hostility in young adults. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain structure & function　222　(1)　61-70　2017/01

DOI： 10.1007/s00429-016-1200-6 　

ISSN： 1863-2653

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Anger typically manifests for only a short period of time, whereas hostility is present for a longer duration. However, both of these emotions are associated with an increased likelihood of psychological problems. The nodes within the neural networks that underlie hostility remain unclear. We presumed that specific nodes might include the anterior midcingulate cortex (aMCC), which seems to be essential for the cognitive aspects of hostility. Thus, the present study first evaluated the associations between regional gray matter density (rGMD) and hostility in 777 healthy young students (433 men and 344 women; 20.7 ± 1.8 years of age) using magnetic resonance imaging and the hostile behaviors subscale (HBS) of the Coronary-prone Type Scale (CTS) for Japanese populations. The HBS scores were positively correlated with rGMD in the aMCC and in widespread frontal regions from the dorsomedial/dorsolateral prefrontal cortices to the lateral premotor cortex at the whole-brain level. No significant correlation was observed between rGMD and the conjunction of HBS and Trait Anger/Anger-Out scores. Furthermore, no significant interaction effects of sex and HBS scores on rGMD were revealed, although the HBS scores of males were significantly higher than those of females. The present findings indicate that the neural correlates of hostility appear to be more distinct in rGMD than those of anger due to differences and duration.
Creative females have larger white matter structures: Evidence from a large sample study. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Human brain mapping　38　(1)　414-430　2017/01

DOI： 10.1002/hbm.23369 　

ISSN： 1065-9471

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The importance of brain connectivity for creativity has been theoretically suggested and empirically demonstrated. Studies have shown sex differences in creativity measured by divergent thinking (CMDT) as well as sex differences in the structural correlates of CMDT. However, the relationships between regional white matter volume (rWMV) and CMDT and associated sex differences have never been directly investigated. In addition, structural studies have shown poor replicability and inaccuracy of multiple comparisons over the whole brain. To address these issues, we used the data from a large sample of healthy young adults (776 males and 560 females; mean age: 20.8 years, SD = 0.8). We investigated the relationship between CMDT and WMV using the newest version of voxel-based morphometry (VBM). We corrected for multiple comparisons over whole brain using the permutation-based method, which is known to be quite accurate and robust. Significant positive correlations between rWMV and CMDT scores were observed in widespread areas below the neocortex specifically in females. These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging. Using rigorous methods, our findings further supported the importance of brain connectivity for creativity as well as its female-specific association. Hum Brain Mapp 38:414-430, 2017. © 2016 Wiley Periodicals, Inc.
A Comprehensive Analysis of the Correlations between Resting-State Oscillations in Multiple-Frequency Bands and Big Five Traits. International-journal Peer-reviewed

Shigeyuki Ikeda, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Frontiers in human neuroscience　11　321-321　2017

DOI： 10.3389/fnhum.2017.00321 　

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Recently, the association between human personality traits and resting-state brain activity has gained interest in neuroimaging studies. However, it remains unclear if Big Five personality traits are represented in frequency bands (~0.25 Hz) of resting-state functional magnetic resonance imaging (fMRI) activity. Based on earlier neurophysiological studies, we investigated the correlation between the five personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI), and the fractional amplitude of low-frequency fluctuation (fALFF) at four distinct frequency bands (slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz) and slow-2 (0.198-0.25 Hz)). We enrolled 835 young subjects and calculated the correlations of resting-state fMRI signals using a multiple regression analysis. We found a significant and consistent correlation between fALFF and the personality trait of extraversion at all frequency bands. Furthermore, significant correlations were detected in distinct brain regions for each frequency band. This finding supports the frequency-specific spatial representations of personality traits as previously suggested. In conclusion, our data highlight an association between human personality traits and fALFF at four distinct frequency bands.
Impact of videogame play on the brain’s microstructural properties: Cross-sectional and longitudinal analyses Peer-reviewed

Takeuchi H, Taki Y, Hashizume H, Asano K, Asano M, Sassa Y, Yokota S, Kotozaki Y, Nouchi R, Kawashima R

Molecular Psychiatry　21　(12)　1781-1789　2016/12

DOI： 10.1038/mp.2015.193 　
Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer. International-journal Peer-reviewed

Atsushi Sekiguchi, Chiho Sato, Izumi Matsudaira, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Masaaki Kawai, Hiroshi Tada, Takanori Ishida, Yasuyuki Taki, Noriaki Ohuchi, Ryuta Kawashima

Scientific reports　6　34671-34671　2016/10/06

DOI： 10.1038/srep34671 　

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Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery. We found a significant group x time interaction in the attentional functions (p = 0.033) and the right thalamus (p < 0.05, small volume correction), suggesting the thalamic volume reduction and attentional dysfunction recovered in patients without adjuvant therapy. Our findings provide a better understanding of the potential role of hormonal therapy in relation to the cognitive dysfunction of cancer survivors.
Now Is the Time to Consider Personalized Effective Dose Peer-reviewed

Hisanori Fukunaga, Akinari Yokoya, Yasuyuki Taki

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS　96　(2)　479-480　2016/10

DOI： 10.1016/j.ijrobp.2016.06.012 　

ISSN： 0360-3016

eISSN： 1879-355X
Application of a tri-axial accelerometry-based portable motion recorder for the quantitative assessment of hippotherapy in children and adolescents with cerebral palsy Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Makoto Takada, Misato Doumura, Masayo Ihara, Yasuyuki Taki, Hirokazu Tsubone, Masahiro Ihara

Journal of Physical Therapy Science　28　(10)　2970-2974　2016/10/01
Publisher: Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai)
DOI： 10.1589/jpts.28.2970 　

ISSN： 0915-5287
Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster. International-journal Peer-reviewed

Seishu Nakagawa, Motoaki Sugiura, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Sugiko Hanawa, Tsuyoshi Araki, Hikaru Takeuchi, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

Scientific reports　6　34364-34364　2016/09/27

DOI： 10.1038/srep34364 　

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The relating to others factor of post-traumatic growth (PTG), which involves mutual help and a strong sense of connection with humanity, is important for young people who are coping with stress. The prefrontal cortex (PFC), especially the dorsolateral PFC (DLPFC), may play an important role in post-traumatic stress disorder (PTSD) with regard to coping and resilience. We hypothesized that the neural correlates of PTG may be responsible for resilience to the correlates of PTSD. Our study tested this hypothesis by examining whether measures of PTG, particularly the measures of relating to others after a disaster, were associated with increased regional grey matter volume (rGMV) in the PFC by assessing individuals who had experienced the East Japan Great Earthquake. We calculated the delta-rGMV by subtracting the rGMV obtained 3 months before the disaster from the rGMV obtained after this disaster using voxel-based morphometry. The magnetic resonance imaging data obtained from 26 subjects (M/F: 21/5; age: 21.2 ± 1.6 yrs.) showed that the total scores on a PTG inventory and the subscore for relating to others at the post-assessment were positively and significantly associated with the delta-rGMV in the right DLPFC. The DLPFC seems to be the main neural correlate of PTG.
The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

DOI： 10.2188/jea.JE20150268 　

ISSN： 0917-5040
Neuroanatomical bases of effortful control: evidence from a large sample of young healthy adults using voxel-based morphometry. International-journal Peer-reviewed

Rui Nouchi, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Yuko Sassa, Ryuta Kawashima

Scientific reports　6　31231-31231　2016/08/09

DOI： 10.1038/srep31231 　

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Effortful control (EC) is a base of individuality in cognition and psychological adjustment. EC is defined as a capacity to control responses and behaviors. We investigated associations between individual differences of EC and regional gray and white matter volume (rGMV/rGMV) in 374 men and 306 women (age, 20.61 ± 1.82 years) using Japanese version of Effortful control scale (J-ECS). J-ECS consists of three subscales such as inhibitory control (IC), activation control (ACTC), and attentional control (ATC). Results showed that (a) IC was associated with larger rGMV in the dorsal part of anterior cingulate cortex (dACC), the supplementary motor area (SMA) and the pre SMA and larger rWMV in the dACC, (b) ACTC was correlated with smaller rGMV in the insula and the putamen, and (c) ATC was associated with larger rWMV in the inferior frontal gyrus, orbital frontal gyrus, ACC, and insula. Our study revealed key neuroanatomical correlations between EC and rGMV and rWMV.
Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure. Peer-reviewed

Hideaki Suzuki, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Satoshi Miyata, Katsutoshi Furukawa, Hiroyuki Arai, Yoshihiro Fukumoto, Yasuyuki Taki, Hiroaki Shimokawa

Circulation journal : official journal of the Japanese Circulation Society　80　(8)　1773-80　2016/07/25

DOI： 10.1253/circj.CJ-16-0367 　

ISSN： 1346-9843

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BACKGROUND: Depressive symptoms and memory impairment are prevalent in patients with chronic heart failure (CHF). Although the mechanisms remain to be elucidated, the hippocampus (an important brain area for emotion and memory) may be a possible neural substrate for these symptoms. METHODS AND RESULTS: We prospectively enrolled 40 Stage C patients, who had past or current CHF symptoms, and as controls 40 Stage B patients, who had structural heart disease but had never had CHF symptoms, in Brain Assessment and Investigation in Heart Failure Trial (B-HeFT) (UMIN000008584). As the primary index, we measured cerebral blood flow (CBF) in the 4 anterior-posterior segments of the hippocampus, using brain MRI analysis. Depressive symptoms, immediate memory (IM) and delayed memory (DM) were assessed using Geriatric Depression Scale (GDS), and Wechsler Memory Scale-revised (WMS-R), respectively. Hippocampus CBF in the most posterior segment was significantly lower in Stage C than in Stage B group (P=0.029 adjusted for Holm's method). Multiple regression analysis identified significant association between hippocampus CBF and GDS or DM score in Stage C group (all P<0.05). GDS score was significantly higher, and IM and DM scores were lower in Stage C patients with hippocampus CBF below the median than those with hippocampus CBF above the median (all P<0.05). CONCLUSIONS: Hippocampus abnormalities are associated with depressive symptoms and cognitive impairment in CHF patients. (Circ J 2016; 80: 1773-1780).
Differences in gray matter structure correlated to nationalism and patriotism. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　6　29912-29912　2016/07/15

DOI： 10.1038/srep29912 　

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Nationalism and patriotism both entail positive evaluations of one's nation. However, the former inherently involves derogation of other nations, whereas the latter is independent of comparisons with other nations. We used voxel-based morphometry and psychological measures and determined nationalism and patriotism's association with gray matter density (rGMD) and their cognitive nature in healthy individuals (433 men and 344 women; age, 20.7 ± 1.9 years) using whole-brain multiple regression analyses and post hoc analyses. We found higher nationalism associated with greater rGMD in (a) areas of the posterior cingulate cortex and greater rGMD in (b) the orbitofrontal cortex, and smaller rGMD in (c) the right amygdala area. Furthermore, we found higher patriotism associated with smaller rGMD in the (d) rostrolateral prefrontal cortex. Post hoc analyses revealed the mean rGMD of the cluster (a) associated with compassion, that of (b) associated with feeling of superiority, that of (c) associated with suicide ideation, and that of (d) associated with quality of life. These results indicate that individual nationalism may be mediated by neurocognitive mechanisms in social-related areas and limbic neural mechanisms, whereas patriotism may be mediated by neurocognitive mechanisms in areas related to well-being.
Value of three-dimensional maximum intensity projection display to assist in magnetic resonance imaging (MRI)-based grading in a mouse model of subarachnoid hemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazumasu Sasaki, Kazuhiro Nakamura, Yasuyuki Taki, Tatsuya Ishikawa

Medical Science Monitor　22　2050-2055　2016/06/16
Publisher: International Scientific Literature Inc.
DOI： 10.12659/MSM.896499 　

ISSN： 1643-3750 1234-1010
OLIG2遺伝子多型(rs1059004)が脳白質の神経線維束の拡散異方性及び安静時脳灌流量に及ぼす効果の検討 Peer-reviewed

小松浩, 竹内光, 菊地淑恵, 小野千晶, 坂井舞, 小高晃, 舩越俊一, 大野高志, 角藤芳久, 高橋雄太, 松岡洋夫, 瀧靖之, 川島隆太, 富田博秋

精神神経学雑誌　(2016特別号)　S367-S367　2016/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
Value of Three-Dimensional Maximum Intensity Projection Display to Assist in Magnetic Resonance Imaging (MRI)-Based Grading in a Mouse Model of Subarachnoid Hemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazumasu Sasaki, Kazuhiro Nakamura, Yasuyuki Taki, Tatsuya Ishikawa

MEDICAL SCIENCE MONITOR　22　2050-2055　2016/06

DOI： 10.12659/MSM.896499 　

ISSN： 1643-3750
Impact of reading habit on white matter structure: Cross-sectional and longitudinal analyses. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

NeuroImage　133　378-389　2016/06

DOI： 10.1016/j.neuroimage.2016.03.037 　

ISSN： 1053-8119

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Psychological studies showed the quantity of reading habit affects the development of their reading skills, various language skills, and knowledge. However, despite a vast amount of literature, the effects of reading habit on the development of white matter (WM) structures critical to language and reading processes have never been investigated. In this study, we used the fractional anisotropy (FA) measure of diffusion tensor imaging to measure WM microstructural properties and examined cross-sectional and longitudinal correlations between reading habit and FA of the WM bundles in a large sample of normal children. In both cross-sectional and longitudinal analyses, we found that greater strength of reading habit positively affected FA in the left arcuate fasciculus (AF), in the left inferior fronto-occipital fasciculus (IFOF), and in the left posterior corona radiata (PCR). Consistent with previous studies, we also confirmed the significance or a tendency for positive correlation between the strength of reading habit and the Verbal Comprehension score in cross-sectional and longitudinal analyses. These cross-sectional and longitudinal findings indicate that a healthy reading habit may be directly or indirectly associated with the advanced development of WM critical to reading and language processes. Future intervention studies are needed to determine the causal effects of reading habits on WM in normal children.
Therapeutic Potential of Natural Product-Based Oral Nanomedicines for Stroke Prevention Peer-reviewed

Tatsushi Mutoh, Tomoko Mutoh, Yasuyuki Taki, Tatsuya Ishikawa

JOURNAL OF MEDICINAL FOOD　19　(6)　521-527　2016/06

DOI： 10.1089/jmf.2015.3644 　

ISSN： 1096-620X

eISSN： 1557-7600
Isoflurane postconditioning with cardiac support promotes recovery from early brain injury in mice after severe subarachnoid hemorrhage Peer-reviewed

Tomoko Mutoh, Tatsushi Mutoh, Kazumasu Sasaki, Yukiko Yamamoto, Yoshiharu Tsuru, Hirokazu Tsubone, Tatsuya Ishikawa, Yasuyuki Taki

LIFE SCIENCES　153　35-40　2016/05

DOI： 10.1016/j.lfs.2016.04.020 　

ISSN： 0024-3205

eISSN： 1879-0631
Reading Aloud and Solving Simple Arithmetic Calculation Intervention (Learning Therapy) Improves Inhibition, Verbal Episodic Memory, Focus Attention and Processing Speed in Healthy Elderly People: Evidence from a Randomized Controlled Trial Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Takayuki Nozawa, Atsushi Sekiguchi, Ryuta Kawashima

FRONTIERS IN HUMAN NEUROSCIENCE　10　217　2016/05

DOI： 10.3389/fnhum.2016.00217 　

ISSN： 1662-5161
RECOVERY FROM BRAIN VOLUME REDUCTION AND COGNITIVE DYSFUNCTIONS 6 MONTHS AFTER SURGERY IN PATIENTS WITH BREAST CANCER Peer-reviewed

Sekiguchi Atsushi, Sato Chiho, Kawai Masaaki, Ishida Takanori, Taki Yasuyuki, Ohuchi Noriaki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　78　(3)　A73　2016/04

ISSN： 0033-3174
Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents Peer-reviewed

Teruo Hashimoto, Kento Fukui, Hikaru Takeuchi, Susumu Yokota, Yoshie Kikuchi, Hiroaki Tomita, Yasuyuki Taki, Ryuta Kawashima

CEREBRAL CORTEX　26　(4)　1795-1803　2016/04

DOI： 10.1093/cercor/bhw020 　

ISSN： 1047-3211

eISSN： 1460-2199
Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy: Prospective study using I-123 BMIPP SPECT/CT Peer-reviewed

Kentaro Takanami, Akira Arai, Rei Umezawa, Takashi Takeuchi, Noriynki Kadoya, Yasuyuki Taki, Keiichi Jingu, Kei Takase

RADIOTHERAPY AND ONCOLOGY　119　(1)　77-83　2016/04

DOI： 10.1016/j.radonc.2016.01.024 　

ISSN： 0167-8140
On the Utility of MIBG SPECT/CT in Evaluating Cardiac Sympathetic Dysfunction in Lewy Body Diseases Peer-reviewed

Hayato Odagiri, Toru Baba, Yoshiyuki Nishio, Osamu Iizuka, Minoru Matsuda, Kentaro Inoue, Akio Kikuchi, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Yasuyuki Taki, Etsuro Mori

PLOS ONE　11　(4)　e0152746　2016/04

DOI： 10.1371/journal.pone.0152746 　

ISSN： 1932-6203
Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents Peer-reviewed

Izumi Matsudaira, Susumu Yokota, Teruo Hashimoto, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

PLOS ONE　11　(4)　e0154220　2016/04

DOI： 10.1371/journal.pone.0154220 　

ISSN： 1932-6203
High-gamma power changes after cognitive intervention: preliminary results from twenty-one senior adult subjects. International-journal Peer-reviewed

Yoritaka Akimoto, Takayuki Nozawa, Akitake Kanno, Toshimune Kambara, Mizuki Ihara, Takeshi Ogawa, Takakuni Goto, Yasuyuki Taki, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Motoaki Sugiura, Eiichi Okumura, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

Brain and behavior　6　(3)　e00427　2016/03

DOI： 10.1002/brb3.427 　

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INTRODUCTION: Brain-imaging techniques have begun to be popular in evaluating the effectiveness of cognitive intervention training. Although gamma activities are rarely used as an index of training effects, they have several characteristics that suggest their potential suitability for this purpose. This pilot study examined whether cognitive training in elderly people affected the high-gamma activity associated with attentional processing and whether high-gamma power changes were related to changes in behavioral performance. METHODS: We analyzed (MEG) magnetoencephalography data obtained from 35 healthy elderly subjects (60-75 years old) who had participated in our previous intervention study in which the subjects were randomly assigned to one of the three types of intervention groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C was trained to solve a crossword puzzle as an active control group. High-gamma (52-100 Hz) activity during a three-stimulus visual oddball task was measured before and after training. As a result of exclusion in the MEG data analysis stage, the final sample consisted of five subjects in Group V, nine subjects in Group P, and seven subjects in Group C. RESULTS: Results showed that high-gamma activities were differently altered between groups after cognitive intervention. In particular, members of Group V, who showed significant improvements in cognitive function after training, exhibited increased high-gamma power in the left middle frontal gyrus during top-down anticipatory target processing. High-gamma power changes in this region were also associated with changes in behavioral performance. CONCLUSIONS: Our preliminary results suggest the usefulness of high-gamma activities as an index of the effectiveness of cognitive training in elderly subjects.
Basal ganglia correlates of fatigue in young adults. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Yuka Kotozaki, Takamitsu Shinada, Tsukasa Maruyama, Atsushi Sekiguchi, Kunio Iizuka, Ryoichi Yokoyama, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Daniele Magistro, Kohei Sakaki, Hyeonjeong Jeong, Yukako Sasaki, Ryuta Kawashima

Scientific reports　6　21386-21386　2016/02/19

DOI： 10.1038/srep21386 　

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Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue outside of clinical subjects. We hypothesized that fatigue without evidence of disease might be related to changes in the basal ganglia and prefrontal cortex and be implicated in fatigue with disease. We aimed to identify the white matter structures of fatigue in young subjects without disease using magnetic resonance imaging (MRI). Healthy young adults (n = 883; 489 males and 394 females) were recruited. As expected, the degrees of fatigue and motivation were associated with larger mean diffusivity (MD) in the right putamen, pallidus and caudate. Furthermore, the degree of physical activity was associated with a larger MD only in the right putamen. Accordingly, motivation was the best candidate for widespread basal ganglia, whereas physical activity might be the best candidate for the putamen. A plausible mechanism of fatigue may involve abnormal function of the motor system, as well as areas of the dopaminergic system in the basal ganglia that are associated with motivation and reward.
Lipomatous hypertrophy of the interatrial septumが疑われた症例

前川由依, 外山由貴, 荒井晃, 高浪健太郎, 高瀬圭, 瀧靖之

核医学　53　(1)　509-509　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
くも膜下出血の脳血管攣縮期におけるCBF-SPECT画像の特徴と限界

武藤達士, 石川達哉, 竹中俊介, 舘脇康子, 武藤友子, 下村英雄, 阿部十也, 中村和浩, 木下俊文, 瀧靖之

核医学　53　(1)　508-508　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
嗄声を主訴に多発リンパ節転移が発見され、FDG-PET/CTにて指摘した前立腺癌の1例

寺尾千秋, 下村英雄, 戸恒智子, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
著明な腹水貯留を呈した原発不明癌に対してFDG-PET/CTを施行した一例

小林洋樹, 下村英雄, 舘脇康子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高浪健太郎, 高瀬圭

核医学　53　(1)　512-512　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
タルクによる胸膜癒着術を施行した1症例におけるFDG-PET所見

榊原宏幸, 荒井晃, 高浪健太郎, 高瀬圭, 戸恒智子, 下村英雄, 舘脇康子, 武藤達士, 瀧靖之, 渡辺みか, 井上健太郎

核医学　53　(1)　568-568　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
脳局所特徴量を用いた年齢推定手法の高精度化に関する検討

藤本竜一, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電気関係学会東北支部連合大会講演論文集　2016　200-200　2016
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2016.0_200 　
Changes in Cognitive Functions in the Elderly Living in Temporary Housing after the Great East Japan Earthquake Peer-reviewed

Aiko Ishiki, Shoji Okinaga, Naoki Tomita, Reiko Kawahara, Ichiro Tsuji, Ryoichi Nagatomi, Yasuyuki Taki, Takashi Takahashi, Masafumi Kuzuya, Shigeto Morimoto, Katsuya Iijima, Takeyoshi Koseki, Hiroyuki Arai, Katsutoshi Furukawa

PLOS ONE　11　(1)　e0147025　2016/01

DOI： 10.1371/journal.pone.0147025 　

ISSN： 1932-6203
Effects of Fast Simple Numerical Calculation Training on Neural Systems Peer-reviewed

Hikaru Takeuchi, Tomomi Nagase, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Rui Nouchi, Ryuta Kawashima

NEURAL PLASTICITY　2016　5940634　2016

DOI： 10.1155/2016/5940634 　

ISSN： 2090-5904

eISSN： 1687-5443
Sex-Related Differences in the Effects of Sleep Habits on Verbal and Visuospatial Working Memory. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in psychology　7　1128-1128　2016

DOI： 10.3389/fpsyg.2016.01128 　

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Poor sleep quality negatively affects memory performance, and working memory in particular. We investigated sleep habits related to sleep quality including sleep duration, daytime nap duration, nap frequency, and dream content recall frequency (DCRF). Declarative working memory can be subdivided into verbal working memory (VWM) and visuospatial working memory (VSWM). We hypothesized that sleep habits would have different effects on VWM and VSWM. To our knowledge, our study is the first to investigate differences between VWM and VSWM related to daytime nap duration, nap frequency, and DCRF. Furthermore, we tested the hypothesis that the effects of duration and frequency of daytime naps and DCRF on VWM and VSWM differed according to sex. We assessed 779 healthy right-handed individuals (434 males and 345 females; mean age: 20.7 ± 1.8 years) using a digit span forward and backward VWM task, a forward and backward VSWM task, and sleep habits scales. A correlation analysis was used to test the relationships between VWM capacity (VWMC) and VSWM capacity (VSWMC) scores and sleep duration, nap duration, nap frequency, and DCRF. Furthermore, multiple regression analyses were conducted to identify factors associated with VWMC and VSWMC scores and to identify sex-related differences. We found significant positive correlations between VSWMC and nap duration and DCRF, and between VWMC and sleep duration in all subjects. Furthermore, we found that working memory capacity (WMC) was positively correlated with nap duration in males and with sleep duration in females, and DCRF was positively correlated with VSWMC in females. Our finding of sex-related differences in the effects of sleep habits on WMC has not been reported previously. The associations between WMC and sleep habits differed according to sex because of differences in the underlying neural correlates of VWM and VSWM, and effectiveness of the sleep habits in males and females.
Age Estimation Using Effective Brain Local Features from T1-Weighted Images Peer-reviewed

Ryuichi Fujimoto, Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2016　5941-5944　2016

DOI： 10.1109/EMBC.2016.7592081 　

ISSN： 1557-170X
The Associations between Regional Gray Matter Structural Changes and Changes of Cognitive Performance in Control Groups of Intervention Studies Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Atsushi Sekiguchi, Tomomi Nagase, Rui Nouchi, Ai Fukushima, Ryuta Kawashima

FRONTIERS IN HUMAN NEUROSCIENCE　9　681　2015/12

DOI： 10.3389/fnhum.2015.00681 　

ISSN： 1662-5161
White matter structures associated with loneliness in young adults. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　5　17001-17001　2015/11/20

DOI： 10.1038/srep17001 　

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Lonely individuals may exhibit dysfunction, particularly with respect to social empathy and self-efficacy. White matter (WM) structures related to loneliness have not yet been identified. We investigated the association between regional WM density (rWMD) using the UCLA Loneliness Scale in 776 healthy young students aged 18-27 years old. Loneliness scores were negatively correlated with rWMD in eight clusters: the bilateral inferior parietal lobule (IPL), right anterior insula (AI), posterior temporoparietal junction (pTPJ), left posterior superior temporal sulcus (pSTS), dorsomedial prefrontal cortex (dmPFC), and rostrolateral prefrontal cortex (RLPFC). The bilateral IPL, right AI, left pSTS, pTPJ, and RLPFC were strongly associated with Empathy Quotient (EQ), whereas the bilateral IPL, right AI, left pTPJ, and dmPFC were associated with General Self-Efficacy Scale (GSES) score. The neural correlates of loneliness comprise widespread reduction in WMD in areas related to self- and social cognition as well as areas associated with empathy and self-efficacy.
Working memory training impacts the mean diffusivity in the dopaminergic system. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Brain structure & function　220　(6)　3101-11　2015/11

DOI： 10.1007/s00429-014-0845-2 　

ISSN： 1863-2653

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Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4 weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components.
Brain structures in the sciences and humanities. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

Brain structure & function　220　(6)　3295-305　2015/11

DOI： 10.1007/s00429-014-0857-y 　

ISSN： 1863-2653

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The areas of academic interest (sciences or humanities) and area of study have been known to be associated with a number of factors associated with autistic traits. However, despite the vast amount of literature on the psychological and physiological characteristics associated with faculty membership, brain structural characteristics associated with faculty membership have never been investigated directly. In this study, we used voxel-based morphometry to investigate differences in regional gray matter volume (rGMV)/regional white matter volume (rWMV) between science and humanities students to test our hypotheses that brain structures previously robustly shown to be altered in autistic subjects are related to differences in faculty membership. We examined 312 science students (225 males and 87 females) and 179 humanities students (105 males and 74 females). Whole-brain analyses of covariance revealed that after controlling for age, sex, and total intracranial volume, the science students had significantly larger rGMV in an anatomical cluster around the medial prefrontal cortex and the frontopolar area, whereas the humanities students had significantly larger rWMV in an anatomical cluster mainly concentrated around the right hippocampus. These anatomical structures have been linked to autism in previous studies and may mediate cognitive functions that characterize differences in faculty membership. The present results may support the ideas that autistic traits and characteristics of the science students compared with the humanities students share certain characteristics from neuroimaging perspectives. This study improves our understanding of differences in faculty membership which is the link among cognition, biological factors, disorders, and education (academia).
Transpulmonary Thermodilution-Based Management of Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage Peer-reviewed

Tatsushi Mutoh, Ken Kazumata, Tomoko Ueyama-Mutoh, Yasuyuki Taki, Tatsuya Ishikawa

AMERICAN JOURNAL OF THE MEDICAL SCIENCES　350　(5)　415-419　2015/11

DOI： 10.1097/MAJ.0000000000000561 　

ISSN： 0002-9629

eISSN： 1538-2990
Neuroanatomical correlates of the sense of control: Gray and white matter volumes associated with an internal locus of control. International-journal Peer-reviewed

Teruo Hashimoto, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　119　146-51　2015/10/01

DOI： 10.1016/j.neuroimage.2015.06.061 　

ISSN： 1053-8119

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A belief that effort is rewarded can develop incentive, achievement motivation, and self-efficacy. Individuals with such a belief attribute causes of events to themselves, not to external, uncontrollable factors, and are thus said to have an internal locus of control. An internal locus of control is a positive personality trait and has been thoroughly studied in applied psychology, but has not been widely examined in neuroscience. In the present study, correlations between locus of control assessment scores and brain volumes were examined in 777 healthy young adults using magnetic resonance imaging. A whole-brain multiple regression analysis with corrections for the effects of age, gender, and intelligence was conducted. Voxel-based morphometry analyses revealed that gray matter volumes in the anterior cingulate cortex, striatum, and anterior insula positively correlated with higher scores, which indicate an internal LOC. In addition, white matter volumes in the striatum showed significant correlations with an internal locus of control. These results suggest that cognitive, socioemotional, self-regulatory, and reward systems might be associated with internal control orientation. The finding of greater volumes in several brain regions in individuals with a stronger internal locus of control indicates that there is a neuroanatomical basis for the belief that one's efforts are rewarded.
Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　119　197-209　2015/10/01

DOI： 10.1016/j.neuroimage.2015.06.058 　

ISSN： 1053-8119

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Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.
Amygdala and cingulate structure is associated with stereotype on sex-role. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Scientific reports　5　14220-14220　2015/09/30

DOI： 10.1038/srep14220 　

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Sex-role egalitarianism (SRE) is the belief that the sex of an individual should not influence the perception of his or her rights, abilities, obligations, and opportunities. Thus, low SRE reflects a more conservative stereotypical view on sex-role. Here we investigated anatomical correlates of individual differences in SRE in the present study. We used voxel-based morphometry, a questionnaire to determine an individual's SRE and associated psychological measures, and determined the association of SRE with gray matter structures and their cognitive nature in healthy individuals (375 men and 306 women; age, 20.6 ± 1.8 years). We demonstrated that higher SRE was associated with smaller regional gray matter density (rGMD) in the anterior part of the posterior cingulate cortex (PCC) and higher rGMD in the right amygdala. Post-hoc analyses revealed psychological measures characterized by contentious interpersonal orientations, such as contentious achievement motivation, were associated with lower SRE and higher rGMD in the anterior part of PCC. Depressive tendencies were associated with lower SRE and higher rGMD in the right amygdala. These findings suggest that variations in stereotype on sex role have roots in the limbic brain structures linked to contentious interpersonal orientation (cingulate) and negative mood (amygdala).
Regional gray matter density is associated with morningness-eveningness: Evidence from voxel-based morphometry. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　117　294-304　2015/08/15

DOI： 10.1016/j.neuroimage.2015.05.037 　

ISSN： 1053-8119

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Diurnal preference (morningness-eveningness) is known to be associated with several individual characteristics that are important in the fields of sociology, education, and psychiatry. Despite this importance, the anatomical correlates of individual differences in morningness-eveningness are unknown, and these were investigated in the present study. We used voxel-based morphometry and a questionnaire to determine individual morningness-eveningness and its association with brain structures in 432 healthy men and 344 healthy women (age, 20.7±1.8years). We demonstrated that morningness (less eveningness) was associated with (a) lower regional gray matter density (rGMD) in the precuneus and adjacent areas, (b) lower rGMD in the left posterior parietal cortex and adjacent areas, and (c) higher rGMD in the bilateral orbitofrontal cortex. Further, our exploratory analyses revealed that (d) higher rGMD in hypothalamic areas around the bilateral suprachiasmatic nuclei were associated with morningness. These findings demonstrate that variations in morningness-eveningness reflect the GM structures of focal regions across the cortex, and suggest a structural basis for individual morningness-eveningness and its association with a wide range of psychological variables distributed across different GM areas of the brain.
Individual differences in cognitive performance and brain structure in typically developing children Peer-reviewed

Susumu Yokota, Hikaru Takeuchi, Teruo Hashimoto, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

DEVELOPMENTAL COGNITIVE NEUROSCIENCE　14　1-7　2015/08

DOI： 10.1016/j.dcn.2015.05.003 　

ISSN： 1878-9293

eISSN： 1878-9307
Sonority-related markedness drives the misperception of unattested onset clusters in French listeners Peer-reviewed

Maïonchi-Pino N, Taki Y, Magnan A, Yokoyama S, Écalle J, Takahashi K, Hashizume H, Kawashima R

L'Année psychologique　115　1-26　2015/06

DOI： 10.4074/S0003503314000086 　
The impact of television viewing on brain structures: cross-sectional and longitudinal analyses. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

Cerebral cortex (New York, N.Y. : 1991)　25　(5)　1188-97　2015/05

DOI： 10.1093/cercor/bht315 　

ISSN： 1047-3211

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Television (TV) viewing is known to affect children's verbal abilities and other physical, cognitive, and emotional development in psychological studies. However, the brain structural development associated with TV viewing has never been investigated. Here we examined cross-sectional correlations between the duration of TV viewing and regional gray/white matter volume (rGMV/rWMV) among 133 boys and 143 girls as well as correlations between the duration of TV viewing and longitudinal changes that occurred a few years later among 111 boys and 105 girls. After correcting for confounding factors, we found positive effects of TV viewing on rGMV of the frontopolar and medial prefrontal areas in cross-sectional and longitudinal analyses, positive effects of TV viewing on rGMV/rWMV of areas of the visual cortex in cross-sectional analyses, and positive effects of TV viewing on rGMV of the hypothalamus/septum and sensorimotor areas in longitudinal analyses. We also confirmed negative effects of TV viewing on verbal intelligence quotient (IQ) in cross-sectional and longitudinal analyses. These anatomical correlates may be linked to previously known effects of TV viewing on verbal competence, aggression, and physical activity. In particular, the present results showed effects of TV viewing on the frontopolar area of the brain, which has been associated with intellectual abilities.
Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

Human brain mapping　36　(5)　1808-27　2015/05

DOI： 10.1002/hbm.22739 　

ISSN： 1065-9471

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Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measured by divergent thinking (VCDT) and novelty seeking based on prior studies suggesting associations between these and dopaminergic functions. We examined this issue in a large sample of right-handed healthy young adults. We used analyses of MD and a psychological measure of VCDT, as well as personality measures of the Temperament and Character Inventory (TCI). Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus. Furthermore, not only higher novelty seeking, but also lower harm avoidance, higher self-directedness, and higher self-transcendence were robustly associated with lower MD in the right globus pallidus, whereas higher persistence was associated with lower MD in the left globus pallidus. These personality variables were also associated with VCDT. The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. These results suggested the MD in the globus pallidus, underlie the association between VCDT and multiple personalities in TCI including novelty seeking.
Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　110　124-35　2015/04/15

DOI： 10.1016/j.neuroimage.2015.01.053 　

ISSN： 1053-8119

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The 5-repeat allele of a common length polymorphism in the gene that encodes the dopamine D4 receptor (DRD4) is robustly associated with the risk of attention deficit hyperactivity disorder (ADHD) and substantially exists in Asian populations, which have a lower ADHD prevalence. In this study, we investigated the effect of this allele on microstructural properties of the brain and on its functional activity during externally directed attention-demanding tasks and creative performance in the 765 Asian subjects. For this purpose, we employed diffusion tensor imaging, N-back functional magnetic resonance imaging paradigms, and a test to measure creativity by divergent thinking. The 5-repeat allele was significantly associated with increased originality in the creative performance, increased mean diffusivity (the measure of how the tissue includes water molecules instead of neural and vessel components) in the widespread gray and white matter areas of extensive areas, particularly those where DRD4 is expressed, and reduced task-induced deactivation in the areas that are deactivated during the tasks in the course of both the attention-demanding working memory task and simple sensorimotor task. The observed neural characteristics of 5-repeat allele carriers may lead to an increased risk of ADHD and behavioral deficits. Furthermore, the increased originality of creative thinking observed in the 5-repeat allele carriers may support the notion of the side of adaptivity of the widespread risk allele of psychiatric diseases.
Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study- Peer-reviewed

Rei Umezawa, Kentaro Takanami, Noriyuki Kadoya, Yujiro Nakajima, Masahide Saito, Hideki Ota, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Ken Takeda, Yasuyuki Taki, Kei Takase, Keiichi Jingu

RADIATION ONCOLOGY　10　96　2015/04

DOI： 10.1186/s13014-015-0410-z 　

ISSN： 1748-717X
The impact of parent-child interaction on brain structures: cross-sectional and longitudinal analyses. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Susumu Yokota, Yuka Kotozaki, Rui Nouchi, Ryuta Kawashima

The Journal of neuroscience : the official journal of the Society for Neuroscience　35　(5)　2233-45　2015/02/04

DOI： 10.1523/JNEUROSCI.0598-14.2015 　

ISSN： 0270-6474

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There is a vast amount of evidence from psychological studies that the amount of parent-child interaction affects the development of children's verbal skills and knowledge. However, despite the vast amount of literature, brain structural development associated with the amount of parent-child interaction has never been investigated. In the present human study, we used voxel-based morphometry to measure regional gray matter density (rGMD) and examined cross-sectional correlations between the amount of time spent with parents and rGMD among 127 boys and 135 girls. We also assessed correlations between the amount of time spent with parents and longitudinal changes that occurred a few years later among 106 boys and 102 girls. After correcting for confounding factors, we found negative effects of spending time with parents on rGMD in areas in the bilateral superior temporal gyrus (STG) via cross-sectional analyses as well as in the contingent areas of the right STG. We also confirmed positive effects of spending time with parents on the Verbal Comprehension score in cross-sectional and longitudinal analyses. rGMD in partly overlapping or contingent areas of the right STG was negatively correlated with age and the Verbal Comprehension score in cross-sectional analyses. Subsequent analyses revealed verbal parent-child interactions have similar effects on Verbal Comprehension scores and rGMD in the right STG in both cross-sectional and longitudinal analyses. These findings indicate that parent-child interactions affect the right STG, which may be associated with verbal skills.
The structure of the amygdala associates with human sexual permissiveness: evidence from voxel-based morphometry. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Human brain mapping　36　(2)　440-8　2015/02

DOI： 10.1002/hbm.22638 　

ISSN： 1065-9471

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Sexual behavior is a critical function of human procreation. Despite previous studies that investigated the neural mechanisms of basic human physiological sexual functions, the neural mechanisms that underlie individual differences in human sexual permissiveness remain unknown. We used voxel-based morphometry and a questionnaire (scale for sexual attitudes) to measure sexual permissiveness to investigate the gray matter and white matter structural correlates of sexual permissiveness. Sexual permissiveness was negatively correlated with regional gray matter density of the structures involving the right amygdala and surrounding areas, and positively correlated with regional white matter density of the white matter area that spread around the left amygdala to the hypothalamus area. There were no gender-specific relationships in the neural correlates of our findings. These findings suggest that structural variations in regions that play key roles in the basic physiological aspects of human sexuality underlie individual complex sexual attitudes in social life.
Comprehensive neural networks for guilty feelings in young adults. International-journal Peer-reviewed

Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　105　248-56　2015/01/15

DOI： 10.1016/j.neuroimage.2014.11.004 　

ISSN： 1053-8119

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Feelings of guilt are associated with widespread self and social cognitions, e.g., empathy, moral reasoning, and punishment. Neural correlates directly related to the degree of feelings of guilt have not been detected, probably due to the small numbers of subjects, whereas there are growing numbers of neuroimaging studies of feelings of guilt. We hypothesized that the neural networks for guilty feelings are widespread and include the insula, inferior parietal lobule (IPL), amygdala, subgenual cingulate cortex (SCC), and ventromedial prefrontal cortex (vmPFC), which are essential for cognitions of guilt. We investigated the association between regional gray matter density (rGMD) and feelings of guilt in 764 healthy young students (422 males, 342 females; 20.7 ± 1.8 years) using magnetic resonance imaging and the guilty feeling scale (GFS) for the younger generation which comprises interpersonal situation (IPS) and rule-breaking situation (RBS) scores. Both the IPS and RBS were negatively related to the rGMD in the right posterior insula (PI). The IPS scores were negatively correlated with rGMD in the left anterior insula (AI), right IPL, and vmPFC using small volume correction. A post hoc analysis performed on the significant clusters identified through these analyses revealed that rGMD activity in the right IPL showed a significant negative association with the empathy quotient. These findings at the whole-brain level are the widespread comprehensive neural network regions for guilty feelings. Interestingly, the novel finding in this study is that the PI was implicated as a common region for feelings of guilt with interaction between the IPS and RBS. Additionally, the neural networks including the IPL were associated with empathy and with regions implicated in moral reasoning (AI and vmPFC), and punishment (AI).
Brain aging using large brain MRI database Peer-reviewed

Yasuyuki Taki

Aging Mechanisms: Longevity, Metabolism, and Brain Aging　291-302　2015/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-55763-0_13 　
Disrupted white matter integrity in anterior corona radiata of patients with anorexia nervosa Peer-reviewed

Y. Sato, E. Aizawa, A. Sekiguchi, Y. Kotozaki, M. Sugiura, Y. Taki, H. Hashizume, T. Kochiyama, R. Kawashima, S. Fukudo

PSYCHOTHERAPY AND PSYCHOSOMATICS　84　(suppl 1)　62-62　2015

ISSN： 0033-3190

eISSN： 1423-0348
Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals Peer-reviewed

Nagasaki M, Yasuda J, Katsuoka F, Nariai N, Kojima K, Kawai Y, Yamaguchi-Kabata Y, Yokozawa J, Danjoh I, Saito S, Sato Y, Mimori T, Tsuda K, Saito R, Pan X, Nishikawa S, Ito S, Kuroki Y, Tanabe O, Fuse N, Kuriyama S, Kiyomoto H, Hozawa A, Minegishi N, Engel J.D, Kinoshita K, Kure S, Yaegashi N, Yamamoto M, Tsuboi A, Nagami F, Kawame H, Tomita H, Tsuji I, Nakaya J, Sugawara J, Suzuki K, Kikuya M, Abe M, Nakaya N, Osumi N, Yamashita R, Ogishima S, Takai T, Tominaga T, Taki Y, Suzuki Y

Nature Communications　6　2015

DOI： 10.1038/ncomms9018 　

eISSN： 2041-1723
Comparison of Postoperative Volume Status and Hemodynamics Between Surgical Clipping and Endovascular Coiling in Patients After Subarachnoid Hemorrhage Peer-reviewed

Tatsushi Mutoh, Ken Kazumata, Yuka Yokoyama, Tatsuya Ishikawa, Yasuyuki Taki, Shunsuke Terasaka, Kiyohiro Houkin

JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY　27　(1)　7-15　2015/01

DOI： 10.1097/ANA.0000000000000066 　

ISSN： 0898-4921

eISSN： 1537-1921
Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats Peer-reviewed

Hideaki Suzuki, Akira Sumiyoshi, Yasuharu Matsumoto, Ben A. Duffy, Takeo Yoshikawa, Mark F. Lythgoe, Kazuhiko Yanai, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Shimokawa

NEUROIMAGE　105　84-92　2015/01

DOI： 10.1016/j.neuroimage.2014.10.040 　

ISSN： 1053-8119

eISSN： 1095-9572
Increased Posterior Hippocampal Volumes in Children with Lower Increase in Body Mass Index: A 3-Year Longitudinal MRI Study Peer-reviewed

Teruo Hashimoto, Hikaru Takeuchi, Yasuyuki Taki, Susumu Yokota, Hiroshi Hashizume, Kohei Asano, Michiko Asano, Yuko Sassa, Rui Nouchi, Ryuta Kawashima

DEVELOPMENTAL NEUROSCIENCE　37　(2)　153-160　2015

DOI： 10.1159/000370064 　

ISSN： 0378-5866

eISSN： 1421-9859
Regional gray matter density associated with cognitive reflectivity-impulsivity: evidence from voxel-based morphometry. International-journal Peer-reviewed

Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

PloS one　10　(3)　e0122666　2015

DOI： 10.1371/journal.pone.0122666 　

ISSN： 1932-6203
Effects of Different Types of Cognitive Training on Cognitive Function, Brain Structure, and Driving Safety in Senior Daily Drivers: A Pilot Study. International-journal Peer-reviewed

Takayuki Nozawa, Yasuyuki Taki, Akitake Kanno, Yoritaka Akimoto, Mizuki Ihara, Ryoichi Yokoyama, Yuka Kotozaki, Rui Nouchi, Atsushi Sekiguchi, Hikaru Takeuchi, Carlos Makoto Miyauchi, Takeshi Ogawa, Takakuni Goto, Takashi Sunda, Toshiyuki Shimizu, Eiji Tozuka, Satoru Hirose, Tatsuyoshi Nanbu, Ryuta Kawashima

Behavioural neurology　2015　525901-525901　2015

DOI： 10.1155/2015/525901 　

ISSN： 0953-4180

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BACKGROUND: Increasing proportion of the elderly in the driving population raises the importance of assuring their safety. We explored the effects of three different types of cognitive training on the cognitive function, brain structure, and driving safety of the elderly. METHODS: Thirty-seven healthy elderly daily drivers were randomly assigned to one of three training groups: Group V trained in a vehicle with a newly developed onboard cognitive training program, Group P trained with a similar program but on a personal computer, and Group C trained to solve a crossword puzzle. Before and after the 8-week training period, they underwent neuropsychological tests, structural brain magnetic resonance imaging, and driving safety tests. RESULTS: For cognitive function, only Group V showed significant improvements in processing speed and working memory. For driving safety, Group V showed significant improvements both in the driving aptitude test and in the on-road evaluations. Group P showed no significant improvements in either test, and Group C showed significant improvements in the driving aptitude but not in the on-road evaluations. CONCLUSION: The results support the effectiveness of the onboard training program in enhancing the elderly's abilities to drive safely and the potential advantages of a multimodal training approach.
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. International-journal Peer-reviewed

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in psychology　6　912-912　2015

DOI： 10.3389/fpsyg.2015.00912 　

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Previous neuroscientific studies have shown that the dopaminergic system plays an important role in creative potential measured by divergent thinking (CPMDT), emotional control, and motivational state. However, although associations between two of these four components have been previously established (e.g., the association between CPMDT and emotional control, the association between CPMDT and motivational state, etc.), the interactions between these four remain unknown. The purpose of this study was to reveal these interactions using path analyses. The Taq1A polymorphism of the dopamine D2 receptor (DRD2) gene was used for this purpose. For measuring emotional intelligence (EI), we used the Japanese version of the Emotional Intelligence Scale. CPMDT was measured using the S-A creativity test. Motivational state was measured using the Vigor subscale of the Japanese version of the Profile of Mood Scale (POMS). Data from 766 healthy, right-handed individuals (426 men and 340 women; 20.7 ± 1.9 years of age) were used in this study. There were significant and robust positive relationships among measures of CPMDT, EI, and motivational state across sex. In addition, the polymorphism of the DRD2 gene was significantly associated with EI, specifically in females. Path analysis in females indicates that the model in which (a) the DRD2 polymorphism primarily facilitates EI, (b) EI in turn facilitates CPMDT and leads to a better motivational state, and (c) a better motivational state also directly facilitates CPMDT explains the data in the most accurate manner. This study suggested a comprehensive picture of the cascade of the associations among dopamine, EI, motivational state, and CPMDT at least in females.
The Relationship between Processing Speed and Regional White Matter Volume in Healthy Young People. International-journal Peer-reviewed

Daniele Magistro, Hikaru Takeuchi, Keyvan Kashkouli Nejad, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Yuko Sassa, Ryuta Kawashima

PloS one　10　(9)　e0136386　2015

DOI： 10.1371/journal.pone.0136386 　

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Processing speed is considered a key cognitive resource and it has a crucial role in all types of cognitive performance. Some researchers have hypothesised the importance of white matter integrity in the brain for processing speed; however, the relationship at the whole-brain level between white matter volume (WMV) and processing speed relevant to the modality or problem used in the task has never been clearly evaluated in healthy people. In this study, we used various tests of processing speed and Voxel-Based Morphometry (VBM) analyses, it is involves a voxel-wise comparison of the local volume of gray and white, to assess the relationship between processing speed and regional WMV (rWMV). We examined the association between processing speed and WMV in 887 healthy young adults (504 men and 383 women; mean age, 20.7 years, SD, 1.85). We performed three different multiple regression analyses: we evaluated rWMV associated with individual differences in the simple processing speed task, word-colour and colour-word tasks (processing speed tasks with words) and the simple arithmetic task, after adjusting for age and sex. The results showed a positive relationship at the whole-brain level between rWMV and processing speed performance. In contrast, the processing speed performance did not correlate with rWMV in any of the regions examined. Our results support the idea that WMV is associated globally with processing speed performance regardless of the type of processing speed task.
Postoperative Structural Brain Changes and Cognitive Dysfunction in Patients with Breast Cancer. International-journal Peer-reviewed

Chiho Sato, Atsushi Sekiguchi, Masaaki Kawai, Yuka Kotozaki, Rui Nouchi, Hiroshi Tada, Hikaru Takeuchi, Takanori Ishida, Yasuyuki Taki, Ryuta Kawashima, Noriaki Ohuchi

PloS one　10　(11)　e0140655　2015

DOI： 10.1371/journal.pone.0140655 　

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OBJECTIVE: The primary purpose of this study was to clarify the influence of the early response to surgery on brain structure and cognitive function in patients with breast cancer. It was hypothesized that the structure of the thalamus would change during the early response after surgery due to the effects of anesthesia and would represent one aspect of an intermediate phenotype of postoperative cognitive dysfunction (POCD). METHODS: We examined 32 postmenopausal females with breast cancer and 20 age-matched controls. We assessed their cognitive function (attention, memory, and executive function), and performed brain structural MRI 1.5 ± 0.5 days before and 5.6 ± 1.2 days after surgery. RESULTS: We found a significant interaction between regional grey matter volume (rGMV) in the thalamus (P < 0.05, familywise error (FWE), small volume correction (SVC)) and one attention domain subtest (P = 0.001, Bonferroni correction) after surgery in the patient group compared with the control group. Furthermore, the changes in attention were significantly associated with sevoflurane anesthetic dose (r2 = 0.247, β = ‒0.471, P = 0.032) and marginally associated with rGMV changes in the thalamus (P = 0.07, FWE, SVC) in the Pt group. CONCLUSION: Our findings suggest that alterations in brain structure, particularly in the thalamus, may occur shortly after surgery and may be associated with attentional dysfunction. This early postoperative response to anesthesia may represent an intermediate phenotype of POCD. It was assumed that patients experiencing other risk factors of POCD, such as the severity of surgery, the occurrence of complications, and pre-existing cognitive impairments, would develop clinical POCD with broad and multiple types of cognitive dysfunction.
An Age Estimation Method Using Brain Local Features for T1-Weighted Images Peer-reviewed

Chihiro Kondo, Koichi Ito, Kai Wu, Kazunori Sato, Yasuyuki Taki, Hiroshi Fukuda, Takafumi Aoki

2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)　2015　666-669　2015

DOI： 10.1109/EMBC.2015.7318450 　

ISSN： 1557-170X
Applying a cognitive training program using a brain training game to patients with schizophrenia: study protocol for a randomized trial Peer-reviewed

Kunio Iizuka, Kazunori Matsumoto, Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Takayuki Nozawa, Hiroshi Hashizume, Ryoichi Yokoyama, Yukako Sasaki, Chika Obara, Hiroo Matsuoka, Ryuta Kawashima

EARLY INTERVENTION IN PSYCHIATRY　8　145-145　2014/11

ISSN： 1751-7885

eISSN： 1751-7893
Correlations between brain structures and study time at home in healthy children: a longitudinal analysis Peer-reviewed

Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Hikaru Takeuchi, Benjamin Thyreau, Yuko Sassa, Ryuta Kawashima

BRAIN AND BEHAVIOR　4　(6)　801-811　2014/11

DOI： 10.1002/brb3.278 　

ISSN： 2162-3279
Regional Reliability of Quantitative Signal Targeting with Alternating Radiofrequency (STAR) Labeling of Arterial Regions (QUASAR) Peer-reviewed

Yasuko Tatewaki, Shuichi Higano, Yasuyuki Taki, Benjamin Thyreau, Takaki Murata, Shunji Mugikura, Daisuke Ito, Kei Takase, Shoki Takahashi

JOURNAL OF NEUROIMAGING　24　(6)　554-561　2014/11

DOI： 10.1111/jon.12076 　

ISSN： 1051-2284

eISSN： 1552-6569
Association between resting-state functional connectivity and empathizing/systemizing. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　99　312-22　2014/10/01

DOI： 10.1016/j.neuroimage.2014.05.031 　

ISSN： 1053-8119

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Empathizing is the drive to identify the mental status of other individuals and respond to it with an appropriate emotion; systemizing is the drive to analyze a system. Previously, we have shown that structures associated with the default mode network (DMN) and external attention system (EAS) are associated with empathizing and systemizing, respectively. Here we investigated the association between resting-state functional connectivity (RSFC) and empathizing/systemizing in 248 healthy young adults. We considered the medial prefrontal cortex (mPFC) and bilateral dorsolateral prefrontal cortices (DLPFCs), which are key nodes of DMN and EAS, as seed regions, and investigated correlations across subjects between individual empathizing/systemizing and RSFC between each seed region and other brain regions. We found that higher empathizing was associated with larger RSFC between the mPFC and areas in (a) the dorsal anterior cingulate cortex (dACC), (b) precuneus, and (c) left superior temporal sulcus (STS). Furthermore, there was an interaction effect between sex and systemizing on RSFC between the left DLPFC and dACC: males showed positive correlations between this RSFC and systemizing, whereas females showed the opposite tendency. Thus, empathizing was associated with increased positive functional coupling with the key node and other nodes of DMN, as well as the area associated with feeling another's pain. Systemizing was associated with increased positive functional coupling between the key nodes of EAS in males. These findings provide further support for the concept of an association between DMN/EAS and empathizing/systemizing.
Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats Peer-reviewed

Akira Sumiyoshi, Yasuyuki Taki, Hiroi Nonaka, Hikaru Takeuchi, Ryuta Kawashima

NEUROIMAGE　98　82-90　2014/09

DOI： 10.1016/j.neuroimage.2014.04.075 　

ISSN： 1053-8119

eISSN： 1095-9572
Prevention of cancer recurrence in tumor margins by stopping microcirculation in the tumor and tumor-host interface Peer-reviewed

Katsuyoshi Hori, Hirotoshi Akita, Hiroi Nonaka, Akira Sumiyoshi, Yasuyuki Taki

CANCER SCIENCE　105　(9)　1196-1204　2014/09

DOI： 10.1111/cas.12477 　

ISSN： 1347-9032

eISSN： 1349-7006
Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: A retrospective observational study Peer-reviewed

Tatsushi Mutoh, Ken Kazumata, Shunsuke Terasaka, Yasuyuki Taki, Akifumi Suzuki, Tatsuya Ishikawa

Critical Care　18　(4)　482　2014/08/12
Publisher: BioMed Central Ltd.
DOI： 10.1186/s13054-014-0482-4 　

ISSN： 1466-609X 1364-8535
Effects of multitasking-training on gray matter structure and resting state neural mechanisms. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Human brain mapping　35　(8)　3646-60　2014/08

DOI： 10.1002/hbm.22427 　

ISSN： 1065-9471

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Multitasking (MT) constitutes engaging in two or more cognitive activities at the same time. MT-training improves performance on untrained MT tasks and alters the functional activity of the brain during MT. However, the effects of MT-training on neural mechanisms beyond MT-related functions are not known. We investigated the effects of 4 weeks of MT-training on regional gray matter volume (rGMV) and functional connectivity during rest (resting-FC) in young human adults. MT-training was associated with increased rGMV in three prefrontal cortical regions (left lateral rostral prefrontal cortex (PFC), dorsolateral PFC (DLPFC), and left inferior frontal junction), the left posterior parietal cortex, and the left temporal and lateral occipital areas as well as decreased resting-FC between the right DLPFC and an anatomical cluster around the ventral anterior cingulate cortex (ACC). Our findings suggest that participation in MT-training is as a whole associated with task-irrelevant plasticity (i.e., neural changes are not limited to certain specific task conditions) in regions and the network that are assumed to play roles in MT as well as diverse higher-order cognitive functions. We could not dissociate the effects of each task component and the diverse cognitive processes involved in MT because of the nature of the study, and these remain to be investigated.
Developmental changes in brain activation involved in the production of novel speech sounds in children. International-journal Peer-reviewed

Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Benjamin Thyreau, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Rui Nouchi, Yuka Kotozaki, Hyeonjeong Jeong, Motoaki Sugiura, Ryuta Kawashima

Human brain mapping　35　(8)　4079-89　2014/08

DOI： 10.1002/hbm.22460 　

ISSN： 1065-9471

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Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech.
Healthy children show gender differences in correlations between nonverbal cognitive ability and brain activation during visual perception Peer-reviewed

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Benjamin Thyreau, Michiko Asano, Hikaru Takeuchi, Ryuta Kawashima

NEUROSCIENCE LETTERS　577　66-71　2014/08

DOI： 10.1016/j.neulet.2014.06.015 　

ISSN： 0304-3940

eISSN： 1872-7972
Regional gray matter volume increases following 7 days of voluntary wheel running exercise: A longitudinal VBM study in rats Peer-reviewed

Sumiyoshi A, Taki Y, Nonaka H, Takeuchi H, Kawashima R

Neuroimage　61　(4)　1206-1212　2014/07

DOI： 10.1016/j.neuroimage.2012.04.010 　

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July 16
Biofeedback-based training for stress management in daily hassles: an intervention study. International-journal Peer-reviewed

Yuka Kotozaki, Hikaru Takeuchi, Atsushi Sekiguchi, Yuki Yamamoto, Takamitsu Shinada, Tsuyoshi Araki, Kei Takahashi, Yasuyuki Taki, Takeshi Ogino, Masashi Kiguchi, Ryuta Kawashima

Brain and behavior　4　(4)　566-79　2014/07

DOI： 10.1002/brb3.241 　

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BACKGROUND: The day-to-day causes of stress are called daily hassles. Daily hassles are correlated with ill health. Biofeedback (BF) is one of the tools used for acquiring stress-coping skills. However, the anatomical correlates of the effects of BF with long training periods remain unclear. In this study, we aimed to investigate this. METHODS: PARTICIPANTS WERE ASSIGNED RANDOMLY TO TWO GROUPS: the intervention group and the control group. Participants in the intervention group performed a biofeedback training (BFT) task (a combination task for heart rate and cerebral blood flow control) every day, for about 5 min once a day. The study outcomes included MRI, psychological tests (e.g., Positive and Negative Affect Schedule, Center for Epidemiologic Studies Depression Scale, and Brief Job Stress Questionnaire), and a stress marker (salivary cortisol levels) before (day 0) and after (day 28) the intervention. RESULTS: We observed significant improvements in the psychological test scores and salivary cortisol levels in the intervention group compared to the control group. Furthermore, voxel-based morphometric analysis revealed that compared to the control group, the intervention group had significantly increased regional gray matter (GM) volume in the right lateral orbitofrontal cortex, which is an anatomical cluster that includes mainly the left hippocampus, and the left subgenual anterior cingulate cortex. The GM regions are associated with the stress response, and, in general, these regions seem to be the most sensitive to the detrimental effects of stress. CONCLUSIONS: Our findings suggest that our BFT is effective against the GM structures vulnerable to stress.
Anatomical correlates of quality of life: evidence from voxel-based morphometry. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Yuko Sassa, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Tomomi Nagase, Carlos Makoto Miyauchi, Ryuta Kawashima

Human brain mapping　35　(5)　1834-46　2014/05

DOI： 10.1002/hbm.22294 　

ISSN： 1065-9471

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Quality of life (QOL) has been defined in many ways, and these definitions usually emphasize happiness and satisfaction with life. Health-related problems are known to cause lower QOL. However, the neural mechanisms underlying individual differences in QOL measured by questionnaire (QOLMQ) in young healthy subjects are unknown. QOL is essential to our well-being, and investigation of the neural mechanisms underlying QOL in uncompromised subjects is obviously of great scientific and social interest. We used voxel-based morphometry to investigate the association between regional gray matter volume (rGMV) and QOLMQ across the brain in healthy young adults (age, 21.4 ± 1.8 years) men (n = 88) and women (n = 68) in humans. We found significant negative relationships between QOLMQ and rGMV in a region in the left rostrolateral prefrontal cortex and regions in the dorsal part of the anterior cingulate gyrus and contingent cingulate regions. These findings show that structural variations in regions associated with processing of negative emotions such as fear and anger as well as those associated with evaluation of internally generated information are associated with QOLMQ. These findings suggest that these processes might be related to QOLMQ in healthy young adults.
Early Intensive Versus Minimally Invasive Approach to Postoperative Hemodynamic Management After Subarachnoid Hemorrhage Peer-reviewed

Tatsushi Mutoh, Ken Kazumata, Shunsuke Terasaka, Yasuyuki Taki, Akifumi Suzuki, Tatsuya Ishikawa

STROKE　45　(5)　1280-1284　2014/05

DOI： 10.1161/STROKEAHA.114.004739 　

ISSN： 0039-2499

eISSN： 1524-4628
NEURAL UNDERPINNINGS OF POSTOPERATIVE COGNITIVE DYSFUNCTIONS (POCD) IN PATIENTS WITH BREAST CANCER Peer-reviewed

Sato Chiho, Sekiguchi Atsushi, Kotozaki Yuka, Nouchi Rui, Takeuchi Hikaru, Taki Yasuyuki, Kawai Masaaki, Tada Hiroshi, Ishida Takanori, Kawashima Ryuta, Ohuchi Noriaki

PSYCHOSOMATIC MEDICINE　76　(3)　A29　2014/04

ISSN： 0033-3174
Resilience after 3/11: structural brain changes 1 year after the Japanese earthquake. Peer-reviewed

Sekiguchi A, Kotozaki Y, Sugiura M, Nouchi R, Takeuchi H, Hanawa S, Nakagawa S, Miyauchi CM, Araki T, Sakuma A, Taki Y, Kawashima R

Molecular psychiatry　20　(5)　552-554　2014/04

DOI： 10.1038/mp.2014.28 　

ISSN： 1359-4184

eISSN： 1476-5578
Four weeks of combination exercise training improved executive functions, episodic memory, and processing speed in healthy elderly people: evidence from a randomized controlled trial Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Atsushi Sekiguchi, Hiroshi Hashizume, Takayuki Nozawa, Haruka Nouchi, Ryuta Kawashima

AGE　36　(2)　787-799　2014/04

DOI： 10.1007/s11357-013-9588-x 　

ISSN： 0161-9152

eISSN： 1574-4647
Association between gray matter volume in the caudate nucleus and financial extravagance: findings from voxel-based morphometry. International-journal Peer-reviewed

Ryoichi Yokoyama, Takayuki Nozawa, Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Kunio Iizuka, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Mayu Hanihara, Yuko Sassa, Ryuta Kawashima

Neuroscience letters　563　28-32　2014/03/20

DOI： 10.1016/j.neulet.2014.01.026 　

ISSN： 0304-3940

eISSN： 1872-7972
脳MRI画像の局所特徴量に基づく年齢推定手法の検討

近藤千裕, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電気関係学会東北支部連合大会講演論文集　2014　208-208　2014
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2014.0_208 　
Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study Peer-reviewed

Tatsushi Mutoh, Ken Kazumata, Shunsuke Terasaka, Yasuyuki Taki, Akifumi Suzuki, Tatsuya Ishikawa

CRITICAL CARE　18　(4)　2014

DOI： 10.1186/s13054-014-0482-4 　

ISSN： 1466-609X

eISSN： 1364-8535
Associations among imaging measures (2): the association between gray matter concentration and task-induced activation changes. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Yuko Sassa, Atsushi Sekuguchi, Yuka Kotozaki, Seishu Nakagawa, Tomomi Nagase, Carlos Makoto Miyauchi, Ryuta Kawashima

Human brain mapping　35　(1)　185-98　2014/01

DOI： 10.1002/hbm.22167 　

ISSN： 1065-9471

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The association between functional activation and gray matter (GM) structure has been revealed in clinical studies and studies of aging involving a small number of subjects. The purpose of this study was to investigate the association between functional activation maps and GM structures in young adults who do not show apparent GM atrophy and to investigate in detail the nature of this association using a large number of subjects. We used voxel-by-voxel regression analyses to investigate voxel-by-voxel associations between GM concentration (GMC) and contrast estimate images of brain activity during n-back working memory tasks. Associations were assessed for each voxel after regressing out the effects of age, sex, and mean signal intensity during functional magnetic resonance imaging scanning at each voxel using data from 248 normal, right-handed, young adult subjects. In our study, the concept of "the greater the GMC, the greater the task-related activation increase/task-related activation decrease (or the greater the task-related activation change from baseline)" was true for a wide range of activated and deactivated areas. However, in some minor regions, the other pattern of "the greater the GMC, the smaller the task-related activation increase" was observed. The first pattern is often observed at the borders of GM structures. These findings may have to be taken into consideration when group/individual differences in functional activation are investigated.
Regional gray matter density is associated with achievement motivation: evidence from voxel-based morphometry. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Brain structure & function　219　(1)　71-83　2014/01

DOI： 10.1007/s00429-012-0485-3 　

ISSN： 1863-2653

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Achievement motivation can be defined as a recurrent need to improve one's past performance. Despite previous functional imaging studies on motivation-related functional activation, the relationship between regional gray matter (rGM) morphology and achievement motivation has never been investigated. We used voxel-based morphometry and a questionnaire (achievement motivation scale) to measure individual achievement motivation and investigated the association between rGM density (rGMD) and achievement motivation [self-fulfillment achievement motivation (SFAM) and competitive achievement motivation (CAM) across the brain in healthy young adults (age 21.0 ± 1.8 years, men (n = 94), women (n = 91)]. SFAM and rGMD significantly and negatively correlated in the orbitofrontal cortex (OFC). CAM and rGMD significantly and positively correlated in the right putamen, insula, and precuneus. These results suggest that the brain areas that play central roles in externally modulated motivation (OFC and putamen) also contribute to SFAM and CAM, respectively, but in different ways. Furthermore, the brain areas in which rGMD correlated with CAM are related to cognitive processes associated with distressing emotions and social cognition, and these cognitive processes may characterize CAM.
White matter microstructural changes as vulnerability factors and acquired signs of post-earthquake distress. International-journal Peer-reviewed

Atsushi Sekiguchi, Motoaki Sugiura, Yasuyuki Taki, Yuka Kotozaki, Rui Nouchi, Hikaru Takeuchi, Tsuyoshi Araki, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Atsushi Sakuma, Ryuta Kawashima

PloS one　9　(1)　e83967　2014

DOI： 10.1371/journal.pone.0083967 　

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Many survivors of severe disasters need psychological support, even those not suffering post-traumatic stress disorder (PTSD). The critical issue in understanding the psychological response after experiencing severe disasters is to distinguish neurological microstructural underpinnings as vulnerability factors from signs of emotional distress acquired soon after the stressful life event. We collected diffusion-tensor magnetic resonance imaging (DTI) data from a group of healthy adolescents before the Great East Japan Earthquake and re-examined the DTIs and anxiety levels of 30 non-PTSD subjects from this group 3-4 months after the earthquake using voxel-based analyses in a longitudinal DTI study before and after the earthquake. We found that the state anxiety level after the earthquake was negatively associated with fractional anisotropy (FA) in the right anterior cingulum (Cg) before the earthquake (r = -0.61, voxel level p<0.0025, cluster level p<0.05 corrected), and positively associated with increased FA changes from before to after the earthquake in the left anterior Cg (r = 0.70, voxel level p<0.0025, cluster level p<0.05 corrected) and uncinate fasciculus (Uf) (r = 0.65, voxel level p<0.0025, cluster level p<0.05 corrected). The results demonstrated that lower FA in the right anterior Cg was a vulnerability factor and increased FA in the left anterior Cg and Uf was an acquired sign of state anxiety after the earthquake. We postulate that subjects with dysfunctions in processing fear and anxiety before the disaster were likely to have higher anxiety levels requiring frequent emotional regulation after the disaster. These findings provide new evidence of psychophysiological responses at the neural network level soon after a stressful life event and might contribute to the development of effective methods to prevent PTSD.
Regional Gray Matter Volume Is Associated with Empathizing and Systemizing in Young Adults Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

PLOS ONE　9　(1)　e84782　2014/01

DOI： 10.1371/journal.pone.0084782 　

ISSN： 1932-6203
Long-term effects of postearthquake distress on brain microstructural changes. International-journal Peer-reviewed

Atsushi Sekiguchi, Yuka Kotozaki, Motoaki Sugiura, Rui Nouchi, Hikaru Takeuchi, Sugiko Hanawa, Seishu Nakagawa, Carlos Makoto Miyauchi, Tsuyoshi Araki, Atsushi Sakuma, Yasuyuki Taki, Ryuta Kawashima

BioMed research international　2014　180468-180468　2014

DOI： 10.1155/2014/180468 　

ISSN： 2314-6133

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Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability factor and increased WMI in the left anterior Cg and uncinate fasciculus (Uf) after the earthquake was an acquired sign of postearthquake distress. However, the long-term effects on WMI remained unclear. Here, we examined the 1-year WMI changes in 25 subjects to clarify long-term effects on the WMI. We found differential FAs in the right anterior Cg, bilateral Uf, left superior longitudinal fasciculus (SLF), and left thalamus, suggesting that synaptic enhancement and shrinkage were long-term effects. Additionally, the correlation between psychological measures related to postearthquake distress and the degree of WMI alternation in the right anterior Cg and the left Uf led us to speculate that temporal WMI changes in some subjects with emotional distress occurred soon after the disaster. We hypothesized that dynamic WMI changes predict a better prognosis, whereas persistently lower WMI is a marker of cognitive dysfunction, implying the development of anxiety disorders.
Creativity measured by divergent thinking is associated with two axes of autistic characteristics. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume

Frontiers in psychology　5　921-921　2014

DOI： 10.3389/fpsyg.2014.00921 　

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Creativity generally involves the conception of original and valuable ideas, and it plays a key role in scientific achievement. Moreover, individuals with autistic spectrum conditions (ASCs) tend to achieve in scientific fields. Recently, it has been proposed that low empathizing and high systemizing characterize individuals with ASCs. Empathizing is the drive to identify the mental status of other individuals and respond to it with an appropriate emotion; systemizing is the drive to analyze a system. It has been proposed that this higher systemizing underlies the scientific achievement of individuals with ASCs, suggesting the possible positive association between creativity and systemizing. However, previous findings on the association between ASCs and creativity were conflicting. Conversely, previous studies have suggested an association between prosocial traits and creativity, indicating the possible association between empathizing and creativity. Here we investigated the association between creativity measured by divergent thinking (CDT) and empathizing, systemizing, and the discrepancy between systemizing and empathizing, which is called D score. CDT was measured using the S-A creativity test. The individual degree of empathizing (empathizing quotient, EQ) and that of systemizing (systemizing quotient, SQ), and D score was measured via a validated questionnaire (SQ and EQ questionnaires). The results showed that higher CDT was significantly and positively correlated with both the score of EQ and the score of SQ but not with D score. These results suggest that CDT is positively associated with one of the characteristics of ASCs (analytical aspects), while exhibiting a negative association with another (lower social aspects). Therefore, the discrepancy between systemizing and empathizing, which is strongly associated with autistic tendency, was not associated with CDT.
Working memory training improves emotional states of healthy individuals. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Makoto Miyauchi, Yuko Sassa, Ryuta Kawashima

Frontiers in systems neuroscience　8　200-200　2014

DOI： 10.3389/fnsys.2014.00200 　

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Working memory (WM) capacity is associated with various emotional aspects, including states of depression and stress, reactions to emotional stimuli, and regulatory behaviors. We have previously investigated the effects of WM training (WMT) on cognitive functions and brain structures. However, the effects of WMT on emotional states and related neural mechanisms among healthy young adults remain unknown. In the present study, we investigated these effects in young adults who underwent WMT or received no intervention for 4 weeks. Before and after the intervention, subjects completed self-report questionnaires related to their emotional states and underwent scanning sessions in which brain activities related to negative emotions were measured. Compared with controls, subjects who underwent WMT showed reduced anger, fatigue, and depression. Furthermore, WMT reduced activity in the left posterior insula during tasks evoking negative emotion, which was related to anger. It also reduced activity in the left frontoparietal area. These findings show that WMT can reduce negative mood and provide new insight into the clinical applications of WMT, at least among subjects with preclinical-level conditions.
A Longitudinal Study of the Relationship Between Personality Traits and the Annual Rate of Volume Changes in Regional Gray Matter in Healthy Adults Peer-reviewed

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

HUMAN BRAIN MAPPING　34　(12)　3347-3353　2013/12

DOI： 10.1002/hbm.22145 　

ISSN： 1065-9471

eISSN： 1097-0193
Resting state functional connectivity associated with trait emotional intelligence. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Hiroshi Hashizume, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashima

NeuroImage　83　318-28　2013/12

DOI： 10.1016/j.neuroimage.2013.06.044 　

ISSN： 1053-8119

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Previous neuroimaging studies have suggested that trait emotional intelligence (TEI) is associated with components of the neural network involved in social cognition (SCN) and somatic marker circuitry (SMC). Our study is the first to investigate the association of TEI with resting-state functional connectivity (RSFC) between the key nodes of SCN and SMC [medial prefromtal cortex (mPFC) and bilateral anterior insula (AI), respectively] and other brain regions. We found that (a) the intrapersonal factor of TEI was negatively correlated with RSFC between mPFC and the anterior part of the right dorsolateral prefrontal cortex (DLPFC), (b) the TEI interpersonal factor score was positively correlated with RSFC between mPFC and the lingual gyrus, and (c) total TEI was positively correlated with RSFC between mPFC and the precuneus as well as (d) between the left AI and the middle part of the right DLPFC. Taken together with previous study findings, our findings can be comprehensively understood as neural mechanisms of SCN and SMC components are associated with TEI. In particular, the fluent interaction between SCN's two key nodes (mPFC and precuneus/PCC) [as well as between DMN's two key nodes] is suggested to be crucial for total TEI. Our study also indicated that (a) a clear functional separation between the two key nodes of the two major intrinsic networks, DMN and the task-positive network (mPFC and DLPFC), is important for higher intrapersonal TEI, (b) brain interactions involving vision-related areas (lingual gyrus) and the key node of SCN (mPFC) are important for interpersonal TEI, and (c) control of DLPFC over the key node of SMC (AI) is important for total TEI.
Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects Peer-reviewed

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

HUMAN BRAIN MAPPING　34　(10)　2418-2424　2013/10

DOI： 10.1002/hbm.22073 　

ISSN： 1065-9471

eISSN： 1097-0193
健常成人における性格と局所灰白質体積減少速度との相関

瀧靖之, Thyreay Thyreau, 木之村重男, 佐藤和則, 後藤了以, 川島隆太, 福田寛

日本老年医学会雑誌　50　(5)　682-682　2013/09
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
Altered brain activity in patients with anorexia nervosa during decision making: an fMRI study Peer-reviewed

Sato Y, Aizawa E, Sekiguchi A, Kotozaki Y, Sugiura M, Taki Y, Hashizume H, Shoji T, Endo Y, Kochiyama T, Kawashima R, Fukudo S

Psychotherapy and Psychosomatics　82　(S1)　98-98　2013/09
A longitudinal study of age- and gender-related annual rate of volume changes in regional gray matter in healthy adults Peer-reviewed

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

HUMAN BRAIN MAPPING　34　(9)　2292-2301　2013/09

DOI： 10.1002/hbm.22067 　

ISSN： 1065-9471
Effects of working memory training on functional connectivity and cerebral blood flow during rest. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Calros M Miyauchi, Yuko Sassa, Ryuta Kawashima

Cortex; a journal devoted to the study of the nervous system and behavior　49　(8)　2106-25　2013/09

DOI： 10.1016/j.cortex.2012.09.007 　

ISSN： 0010-9452

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Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-FC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-FC between the key DMN node and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-FC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training.
Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation. International-journal Peer-reviewed

Hideaki Suzuki, Akira Sumiyoshi, Yasuyuki Taki, Yasuharu Matsumoto, Yoshihiro Fukumoto, Ryuta Kawashima, Hiroaki Shimokawa

NeuroImage　77　215-21　2013/08/15

DOI： 10.1016/j.neuroimage.2013.03.042 　

ISSN： 1053-8119

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Cardiac arrest and subsequent cardiopulmonary resuscitation (CPR) induce hippocampal damage, which has been identified using histological analysis of post-mortem brains. Voxel-based morphometry (VBM), an in-vivo assessment of regional differences in the concentration or volume of a particular tissue such as gray matter, has revealed CPR-induced decreases in gray matter in the hippocampus, where histopathological findings were observed. However, the potential link between the changes in gray matter detected by VBM and hippocampal damage has not been investigated directly. In this study, we compared results obtained using VBM directly to results from histological analyses in the same CPR rat brains, which exhibited neuronal loss and microglial invasion in the CA1 region of the hippocampus (CA1). T2-weighted images were obtained and preprocessed for VBM to produce gray matter concentration (GMC) maps in rats with asphyxia-induced cardiac arrest and CPR and sham-operated controls (n=12 each). Brains were fixed, and the number of neurons and microglia in CA1 were counted. VBM revealed a significant decrease in GMC in CPR rats compared to sham-operated controls. The CPR-induced decrease in GMC was localized to CA1, which is the same brain region where neuronal loss and microglial invasion were noted in response to CPR. GMC values were positively correlated with the number of neurons and tended to be negatively correlated with the number of microglia in CA1 of CPR rats. In conclusion, these results indicate that VBM-detected alterations in gray matter can be used as a surrogate marker for hippocampal damage following CPR.
Interactions between the heart and the brain in heart failure patients assessed by magnetic resonance imaging - interim results from Brain assessment and investigation in Heart Failure Trial (B-HeFT) Peer-reviewed

H. Suzuki, Y. Matsumoto, H. Ota, Y. Kotozaki, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

European Heart Journal　34　(suppl 1)　P2732-P2732　2013/08/02
Publisher: Oxford University Press (OUP)
DOI： 10.1093/eurheartj/eht309.p2732 　

ISSN： 0195-668X

eISSN： 1522-9645
Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region-of-interest analyses in 246 healthy children. International-journal Peer-reviewed

Yasuyuki Taki, Benjamin Thyreau, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Human brain mapping　34　(8)　1842-56　2013/08

DOI： 10.1002/hbm.22027 　

ISSN： 1065-9471

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In this study, we examined linear and curvilinear correlations of fractional anisotropy (FA), mean diffusivity (MD), and white matter volume with age by using brain structural and diffusion-tensor magnetic resonance imaging (MRI) in a large number of healthy children and voxel-based morphometry (VBM) and region-of-interest (ROI) analyses. We collected data by brain structural MRI in 246 healthy children, aged 5-18 years. FA and MD images were normalized using the normalization parameter of the corresponding structural MRI. Next, we analyzed the correlations between FA and age and between MD and age by estimating linear and logarithmic functions. We also analyzed the correlation between white matter volume and age by linear, quadratic, and cubic functions. Correlations between FA and age and between MD and age showed exponential trajectories in most ROIs in boys and girls, except for several fibers, such as the corpus callosum connecting the bilateral rectal gyri in boys. The correlation between white matter volume and age showed significant positive linear trajectories in most ROIs in boys and girls, except for a few fibers, such as the bilateral uncinate fasciculus. Additionally, maturational rates differed among major fibers, and in girls, the left superior longitudinal fasciculus, which connects the frontal and temporal lobes, showed a slower rate of maturation than other fibers. Our results may help to clarify the mechanisms of normal brain maturation from the viewpoint of brain white matter.
Linear and curvilinear correlations of brain gray matter volume and density with age using voxel-based morphometry with the Akaike information criterion in 291 healthy children. International-journal Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Human brain mapping　34　(8)　1857-71　2013/08

DOI： 10.1002/hbm.22033 　

ISSN： 1065-9471

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We examined linear and curvilinear correlations of gray matter volume and density in cortical and subcortical gray matter with age using magnetic resonance images (MRI) in a large number of healthy children. We applied voxel-based morphometry (VBM) and region-of-interest (ROI) analyses with the Akaike information criterion (AIC), which was used to determine the best-fit model by selecting which predictor terms should be included. We collected data on brain structural MRI in 291 healthy children aged 5-18 years. Structural MRI data were segmented and normalized using a custom template by applying the diffeomorphic anatomical registration using exponentiated lie algebra (DARTEL) procedure. Next, we analyzed the correlations of gray matter volume and density with age in VBM with AIC by estimating linear, quadratic, and cubic polynomial functions. Several regions such as the prefrontal cortex, the precentral gyrus, and cerebellum showed significant linear or curvilinear correlations between gray matter volume and age on an increasing trajectory, and between gray matter density and age on a decreasing trajectory in VBM and ROI analyses with AIC. Because the trajectory of gray matter volume and density with age suggests the progress of brain maturation, our results may contribute to clarifying brain maturation in healthy children from the viewpoint of brain structure.
White matter structures associated with empathizing and systemizing in young adults Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Benjamin Thyreau, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Tomomi Nagase, Rui Nouchi, Ai Fukushima, Ryuta Kawashima

NEUROIMAGE　77　222-236　2013/08

DOI： 10.1016/j.neuroimage.2013.04.004 　

ISSN： 1053-8119
Brain structures associated with executive functions during everyday events in a non-clinical sample Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

BRAIN STRUCTURE & FUNCTION　218　(4)　1017-1032　2013/07

DOI： 10.1007/s00429-012-0444-z 　

ISSN： 1863-2653
Correlation between pulmonary function and brain volume in healthy elderly subjects. International-journal Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Satoru Ebihara, Benjamin Thyreau, Kazunori Sato, Ryoi Goto, Masako Kakizaki, Ichiro Tsuji, Ryuta Kawashima, Hiroshi Fukuda

Neuroradiology　55　(6)　689-95　2013/06

DOI： 10.1007/s00234-013-1157-6 　

ISSN： 0028-3940

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INTRODUCTION: Cigarette smoking decreases brain regional gray matter volume and is related to chronic obstructive lung disease (COPD). COPD leads to decreased pulmonary function, which is represented by forced expiratory volume in one second percentage (FEV1.0 %); however, it is unclear if decreased pulmonary function is directly related to brain gray matter volume decline. Because there is a link between COPD and cognitive decline, revealing a direct relationship between pulmonary function and brain structure is important to better understand how pulmonary function affects brain structure and cognitive function. Therefore, the purpose of this study was to analyze whether there were significant correlations between FEV1.0 % and brain regional gray and white matter volumes using brain magnetic resonance (MR) image data from 109 community-dwelling healthy elderly individuals. METHODS: Brain MR images were processed with voxel-based morphometry using a custom template by applying diffeomorphic anatomical registration using the exponentiated lie algebra procedure. RESULTS: We found a significant positive correlation between the regional white matter volume of the cerebellum and FEV1.0 % after adjusting for age, sex, and intracranial volume. CONCLUSION: Our results suggest that elderly individuals who have a lower FEV1.0 % have decreased regional white matter volume in the cerebellum. Therefore, preventing decreased pulmonary function is important for cerebellar white matter volume in the healthy elderly population.
Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress Peer-reviewed

A. Sekiguchi, M. Sugiura, Y. Taki, Y. Kotozaki, R. Nouchi, H. Takeuchi, T. Araki, S. Hanawa, S. Nakagawa, C. M. Miyauchi, A. Sakuma, R. Kawashima

MOLECULAR PSYCHIATRY　18　(5)　618-623　2013/05

DOI： 10.1038/mp.2012.51 　

ISSN： 1359-4184

eISSN： 1476-5578
White matter structures associated with emotional intelligence: Evidence from diffusion tensor imaging Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Tomomi Nagase, Rui Nouchi, Ai Fukushima, Ryuta Kawashima

HUMAN BRAIN MAPPING　34　(5)　1025-1034　2013/05

DOI： 10.1002/hbm.21492 　

ISSN： 1065-9471
Is the phonological deficit in developmental dyslexia related to impaired phonological representations and to universal phonological grammar? Peer-reviewed

Norbert Maionchi-Pino, Yasuyuki Taki, Satoru Yokoyama, Annie Magnan, Kei Takahashi, Hiroshi Hashizume, Jean Ecalle, Ryuta Kawashima

JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY　115　(1)　53-73　2013/05

DOI： 10.1016/j.jecp.2012.10.006 　

ISSN： 0022-0965
Desflurane but not sevoflurane augments laryngeal C-fiber inputs to nucleus tractus solitarii neurons by activating transient receptor potential-A1 Peer-reviewed

Tatsushi Mutoh, Yasuyuki Taki, Hirokazu Tsubone

LIFE SCIENCES　92　(14-16)　821-828　2013/05

DOI： 10.1016/j.lfs.2013.02.015 　

ISSN： 0024-3205
A longitudinal study of structural brain network changes with normal aging Peer-reviewed

Kai Wu, Yasuyuki Taki, Kazunori Sato, Haochen Qi, Ryuta Kawashima, Hiroshi Fukuda

Frontiers in Human Neuroscience　7　(2013)　113　2013/04/03

DOI： 10.3389/fnhum.2013.00113 　

ISSN： 1662-5161
RESILIENCE AFTER 3/11: BRAIN STRUCTURAL CHANGES ONE-YEAR AFTER THE GREAT EAST JAPAN EARTHQUAKE Peer-reviewed

Sekiguchi Atsushi, Sugiura Motoaki, Kotozaki Yuka, Araki Tsuyoshi, Hanawa Sugiko, Nakagawa Seishu, Miyauchi Carlos M, Sakuma Atsushi, Taki Yasuyuki, Kawashima Ryuta

PSYCHOSOMATIC MEDICINE　75　(3)　A69-A70　2013/04

ISSN： 0033-3174
Anatomical correlates of self-handicapping tendency. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Yuko Sassa, Ryuta Kawashima

Cortex; a journal devoted to the study of the nervous system and behavior　49　(4)　1148-54　2013/04

DOI： 10.1016/j.cortex.2013.01.014 　

ISSN： 0010-9452

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Self-handicaps are obstacles created (or claimed) by individuals in anticipation of failure. Despite the vast amount of psychological research on self-handicapping tendency, the neural mechanisms underlying individual differences in self-handicapping tendency in young and healthy subjects are unknown. We used voxel-based morphometry (VBM) and a questionnaire to measure individual self-handicapping tendency, and we investigated the association between regional gray matter volume (rGMV) and self-handicapping tendency across the brain in healthy young adult (mean age, 21.3 years; standard deviation - SD = 1.9) men (n = 94) and women (n = 91). We discovered that higher individual self-handicapping tendency was associated with larger rGMV in the subgenual cingulate gyrus (sgCG). A wide range of previous studies showed (a) the opposite pattern is seen in the association between rGMV in the sgCG and depression and (b) this area is active when negative emotions are suppressed. The present results suggest that the sgCG is also involved in self-handicapping, which is a behavior thought to be engaged in the protection of self-esteem.
Topological Organization of Functional Brain Networks in Healthy Children: Differences in Relation to Age, Sex, and Intelligence Peer-reviewed

Kai Wu, Yasuyuki Taki, Kazunori Sato, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Benjamin Thyreau, Yong He, Alan C. Evans, Xiaobo Li, Ryuta Kawashima, Hiroshi Fukuda

PLOS ONE　8　(2)　e55347　2013/02

DOI： 10.1371/journal.pone.0055347 　

ISSN： 1932-6203
Brain training game boosts executive functions, working memory and processing speed in the young adults: a randomized controlled trial. International-journal Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Toshimune Kambara, Atsushi Sekiguchi, Carlos Makoto Miyauchi, Yuka Kotozaki, Haruka Nouchi, Ryuta Kawashima

PloS one　8　(2)　e55518　2013

DOI： 10.1371/journal.pone.0055518 　

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BACKGROUND: Do brain training games work? The beneficial effects of brain training games are expected to transfer to other cognitive functions. Yet in all honesty, beneficial transfer effects of the commercial brain training games in young adults have little scientific basis. Here we investigated the impact of the brain training game (Brain Age) on a wide range of cognitive functions in young adults. METHODS: We conducted a double-blind (de facto masking) randomized controlled trial using a popular brain training game (Brain Age) and a popular puzzle game (Tetris). Thirty-two volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into eight categories (fluid intelligence, executive function, working memory, short-term memory, attention, processing speed, visual ability, and reading ability). RESULTS AND DISCUSSION: Our results showed that commercial brain training game improves executive functions, working memory, and processing speed in young adults. Moreover, the popular puzzle game can engender improvement attention and visuo-spatial ability compared to playing the brain training game. The present study showed the scientific evidence which the brain training game had the beneficial effects on cognitive functions (executive functions, working memory and processing speed) in the healthy young adults. CONCLUSIONS: Our results do not indicate that everyone should play brain training games. However, the commercial brain training game might be a simple and convenient means to improve some cognitive functions. We believe that our findings are highly relevant to applications in educational and clinical fields. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000005618.
Neural correlates of deception in social contexts in normally developing children. International-journal Peer-reviewed

Susumu Yokota, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Benjamin Thyreau, Mari Tanaka, Ryuta Kawashima

Frontiers in human neuroscience　7　206-206　2013

DOI： 10.3389/fnhum.2013.00206 　

ISSN： 1662-5161
Association of hair iron levels with creativity and psychological variables related to creativity. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Rui Nouchi, Yuka Kotozaki, Seishu Nakagawa, Carlos M Miyauchi, Kunio Iizuka, Ryoichi Yokoyama, Takamitsu Shinada, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Hiroshi Hashizume, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

Frontiers in human neuroscience　7　875-875　2013

DOI： 10.3389/fnhum.2013.00875 　

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Creativity generally involves the conception of original and valuable ideas. Previous studies have suggested an association between creativity and the dopaminergic system, and that physical activity facilitates creativity. Iron plays a key role in the dopaminergic system and physical activity. Here, we newly investigated the associations between hair iron levels and creativity, dopamine-related traits and states [novelty seeking, extraversion, and vigor (motivational state)], as well as the physical activity level. In the present study, we addressed this issue by performing a hair mineral analysis to determine iron levels and a behavioral creativity test of divergent thinking and related psychological measures among young adults (254 men, 88 women; mean age 20.79 ± 2.03 years). Iron levels did not show any significant association with creativity but displayed significant positive associations with novelty seeking, extraversion, and physical activity level. These results may be partly congruent with the notion that iron plays a key role in the dopaminergic system and imply that iron is important for traits and physical activity, which facilitate creativity. Future interventional or longitudinal studies are warranted to identify any causal effects.
The Association between Resting Functional Connectivity and Creativity Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

CEREBRAL CORTEX　22　(12)　2921-2929　2012/12

DOI： 10.1093/cercor/bhr371 　

ISSN： 1047-3211

eISSN： 1460-2199
A voxel-based morphometry study of gray and white matter correlates of a need for uniqueness. International-journal Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Atsushi Sekiguchi, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Hiroshi Hashizume, Seishu Nakagawa, Keiko Kunitoki, Yuko Sassa, Ryuta Kawashima

NeuroImage　63　(3)　1119-26　2012/11/15

DOI： 10.1016/j.neuroimage.2012.08.037 　

ISSN： 1053-8119

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People appear to derive intrinsic satisfaction from the perception that they are unique, special, and separable from the masses, which is referred to as a need for uniqueness (NFU). NFU is a universal human trait, along with a tendency to conform to the beliefs and attitudes of others and social norms. We used voxel-based morphometry and a questionnaire to determine individual NFU and its association with brain structures in healthy men (94) and women (91; age, 21.3 ± 1.9 years). Individual NFU was associated with smaller gray matter volume of a cluster that included areas in (a) the left middle temporal gyrus, left superior temporal gyrus, and left superior temporal sulcus (STS); (b) the dorsal part of the anterior cingulate gyrus and the anterior part of the middle cingulate gyrus; and (c) the right inferior frontal gyrus and the ventral part of the precentral gyrus. Individual NFU was also associated with larger white matter concentration of a cluster that mainly included the body of the corpus callosum. These findings demonstrated that variations in NFU reflect the gray and white matter structures of focal regions. These findings suggest a biological basis for individual NFU, distributed across different gray and white matter areas of the brain.
Beneficial effects of short-term combination exercise training on diverse cognitive functions in healthy older people: study protocol for a randomized controlled trial Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi, Ryuta Kawashima

TRIALS　13　200　2012/10

DOI： 10.1186/1745-6215-13-200 　

ISSN： 1745-6215
健常成人の加齢における局所脳灰白質量の減少 383人の脳MRI解析による縦断研究

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, Wu Kai, 川島隆太, 福田寛

日本老年医学会雑誌　49　(5)　654-654　2012/09
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
The correlation between brain gray matter volume and empathizing and systemizing quotients in healthy children Peer-reviewed

Yuko Sassa, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Michiko Asano, Kohei Asano, Akio Wakabayashi, Ryuta Kawashima

NEUROIMAGE　60　(4)　2035-2041　2012/05

DOI： 10.1016/j.neuroimage.2012.02.021 　

ISSN： 1053-8119
Beneficial effects of reading aloud and solving simple arithmetic calculations (learning therapy) on a wide range of cognitive functions in the healthy elderly: study protocol for a randomized controlled trial Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Takayuki Nozawa, Atsushi Sekiguchi, Haruka Nouchi, Ryuta Kawashima

TRIALS　13　32　2012/04

DOI： 10.1186/1745-6215-13-32 　

ISSN： 1745-6215
Age-related changes in topological organization of structural brain networks in healthy individuals Peer-reviewed

Kai Wu, Yasuyuki Taki, Kazunori Sato, Shigeo Kinomura, Ryoi Goto, Ken Okada, Ryuta Kawashima, Yong He, Alan C. Evans, Hiroshi Fukuda

HUMAN BRAIN MAPPING　33　(3)　552-568　2012/03

DOI： 10.1002/hbm.21232 　

ISSN： 1065-9471

eISSN： 1097-0193
Sleep duration during weekdays affects hippocampal gray matter volume in healthy children. International-journal Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　60　(1)　471-5　2012/03

DOI： 10.1016/j.neuroimage.2011.11.072 　

ISSN： 1053-8119

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Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18 years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.
健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 福田寛, 川島隆太

日本医学放射線学会学術集会抄録集　71回　S199-S199　2012/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Regional gray and white matter volume associated with Stroop interference: Evidence from voxel-based morphometry Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Tomomi Nagase, Rui Nouchi, Ai Fukushima, Ryuta Kawashima

NEUROIMAGE　59　(3)　2899-2907　2012/02

DOI： 10.1016/j.neuroimage.2011.09.064 　

ISSN： 1053-8119
Correlation among body height, intelligence, and brain gray matter volume in healthy children. International-journal Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Kohei Asano, Yuka Kotozaki, Rui Nouchi, Kai Wu, Hiroshi Fukuda, Ryuta Kawashima

NeuroImage　59　(2)　1023-7　2012/01/16

DOI： 10.1016/j.neuroimage.2011.08.092 　

ISSN： 1053-8119

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A significant positive correlation between height and intelligence has been demonstrated in children. Additionally, intelligence has been associated with the volume of gray matter in the brains of children. Based on these correlations, we analyzed the correlation among height, full-scale intelligence quotient (IQ) and gray matter volume applying voxel-based morphometry using data from the brain magnetic resonance images of 160 healthy children aged 5-18 years of age. As a result, body height was significantly positively correlated with brain gray matter volume. Additionally, the regional gray matter volume of several regions such as the bilateral prefrontal cortices, temporoparietal region, and cerebellum was significantly positively correlated with body height and that the gray matter volume of several of these regions was also significantly positively correlated with full-scale intelligence quotient (IQ) scores after adjusting for age, sex, and socioeconomic status. Our results demonstrate that gray and white matter volume may mediate the correlation between body height and intelligence in healthy children. Additionally, the correlations among gray and white matter volume, height, and intelligence may be at least partially explained by the effect of insulin-like growth factor-1 and growth hormones. Given the importance of the effect of environmental factors, especially nutrition, on height, IQ, and gray matter volume, the present results stress the importance of nutrition during childhood for the healthy maturation of body and brain.
Brain training game improves executive functions and processing speed in the elderly: a randomized controlled trial. International-journal Peer-reviewed

Rui Nouchi, Yasuyuki Taki, Hikaru Takeuchi, Hiroshi Hashizume, Yuko Akitsuki, Yayoi Shigemune, Atsushi Sekiguchi, Yuka Kotozaki, Takashi Tsukiura, Yukihito Yomogida, Ryuta Kawashima

PloS one　7　(1)　e29676　2012

DOI： 10.1371/journal.pone.0029676 　

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BACKGROUND: The beneficial effects of brain training games are expected to transfer to other cognitive functions, but these beneficial effects are poorly understood. Here we investigate the impact of the brain training game (Brain Age) on cognitive functions in the elderly. METHODS AND RESULTS: Thirty-two elderly volunteers were recruited through an advertisement in the local newspaper and randomly assigned to either of two game groups (Brain Age, Tetris). This study was completed by 14 of the 16 members in the Brain Age group and 14 of the 16 members in the Tetris group. To maximize the benefit of the interventions, all participants were non-gamers who reported playing less than one hour of video games per week over the past 2 years. Participants in both the Brain Age and the Tetris groups played their game for about 15 minutes per day, at least 5 days per week, for 4 weeks. Each group played for a total of about 20 days. Measures of the cognitive functions were conducted before and after training. Measures of the cognitive functions fell into four categories (global cognitive status, executive functions, attention, and processing speed). Results showed that the effects of the brain training game were transferred to executive functions and to processing speed. However, the brain training game showed no transfer effect on any global cognitive status nor attention. CONCLUSIONS: Our results showed that playing Brain Age for 4 weeks could lead to improve cognitive functions (executive functions and processing speed) in the elderly. This result indicated that there is a possibility which the elderly could improve executive functions and processing speed in short term training. The results need replication in large samples. Long-term effects and relevance for every-day functioning remain uncertain as yet. TRIAL REGISTRATION: UMIN Clinical Trial Registry 000002825.
Neural Correlates of the Difference between Working Memory Speed and Simple Sensorimotor Speed: An fMRI Study Peer-reviewed

Hikaru Takeuchi, Motoaki Sugiura, Yuko Sassa, Atsushi Sekiguchi, Yukihito Yomogida, Yasuyuki Taki, Ryuta Kawashima

PLOS ONE　7　(1)　e30579　2012/01

DOI： 10.1371/journal.pone.0030579 　

ISSN： 1932-6203
Brain development in childhood. Peer-reviewed

Taki Y, Kawashima R

The open neuroimaging journal　6　103-110　2012

DOI： 10.2174/1874440001206010103 　
Correlation Between Gray Matter Density-Adjusted Brain Perfusion and Age Using Brain MR Images of 202 Healthy Children Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

HUMAN BRAIN MAPPING　32　(11)　1973-1985　2011/11

DOI： 10.1002/hbm.21163 　

ISSN： 1065-9471
Neural Bases of a Specific Strategy for Visuospatial Processing in Rugby Players Peer-reviewed

Atsushi Sekiguchi, Satoru Yokoyama, Satoshi Kasahara, Yukihito Yomogida, Hikaru Takeuchi, Takeshi Ogawa, Yasuyuki Taki, Shin-Ichi Niwa, Ryuta Kawashima

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE　43　(10)　1857-1862　2011/10

DOI： 10.1249/MSS.0b013e31821920f3 　

ISSN： 0195-9131
Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NEUROIMAGE　58　(3)　709-715　2011/10

DOI： 10.1016/j.neuroimage.2011.07.020 　

ISSN： 1053-8119
Verbal working memory performance correlates with regional white matter structures in the frontoparietal regions Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

NEUROPSYCHOLOGIA　49　(12)　3466-3473　2011/10

DOI： 10.1016/j.neuropsychologia.2011.08.022 　

ISSN： 0028-3932
Regional Gray Matter Density Associated With Emotional Intelligence: Evidence From Voxel-Based Morphometry Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

HUMAN BRAIN MAPPING　32　(9)　1497-1510　2011/09

DOI： 10.1002/hbm.21122 　

ISSN： 1065-9471
Cerebral Blood Flow during Rest Associates with General Intelligence and Creativity Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

PLOS ONE　6　(9)　e25532　2011/09

DOI： 10.1371/journal.pone.0025532 　

ISSN： 1932-6203
Effects of Training of Processing Speed on Neural Systems Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

JOURNAL OF NEUROSCIENCE　31　(34)　12139-12148　2011/08

DOI： 10.1523/JNEUROSCI.2948-11.2011 　

ISSN： 0270-6474
Working Memory Training Using Mental Calculation Impacts Regional Gray Matter of the Frontal and Parietal Regions Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

PLOS ONE　6　(8)　e23175　2011/08

DOI： 10.1371/journal.pone.0023175 　

ISSN： 1932-6203
Correlations among Brain Gray Matter Volumes, Age, Gender, and Hemisphere in Healthy Individuals Peer-reviewed

Yasuyuki Taki, Benjamin Thyreau, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda

PLOS ONE　6　(7)　e22734　2011/07

DOI： 10.1371/journal.pone.0022734 　

ISSN： 1932-6203
Correlation between degree of white matter hyperintensities and global gray matter volume decline rate Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

NEURORADIOLOGY　53　(6)　397-403　2011/06

DOI： 10.1007/s00234-010-0746-x 　

ISSN： 0028-3940
A longitudinal study of gray matter volume decline with age and modifying factors Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Ryuta Kawashima, Hiroshi Fukuda

NEUROBIOLOGY OF AGING　32　(5)　907-915　2011/05

DOI： 10.1016/j.neurobiolaging.2009.05.003 　

ISSN： 0197-4580
The Overlapping Community Structure of Structural Brain Network in Young Healthy Individuals Peer-reviewed

Kai Wu, Yasuyuki Taki, Kazunori Sato, Yuko Sassa, Kentaro Inoue, Ryoi Goto, Ken Okada, Ryuta Kawashima, Yong He, Alan C. Evans, Hiroshi Fukuda

PLOS ONE　6　(5)　e19608　2011/05

DOI： 10.1371/journal.pone.0019608 　

ISSN： 1932-6203
Failing to deactivate: The association between brain activity during a working memory task and creativity Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Tomomi Nagase, Rui Nouchi, Ryuta Kawashima

NEUROIMAGE　55　(2)　681-687　2011/03

DOI： 10.1016/j.neuroimage.2010.11.052 　

ISSN： 1053-8119
Correlation between gray/white matter volume and cognition in healthy elderly people Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

BRAIN AND COGNITION　75　(2)　170-176　2011/03

DOI： 10.1016/j.bandc.2010.11.008 　

ISSN： 0278-2626
383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, Wu Kai, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　70回　S289-S289　2011/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Effects of Aging on Hippocampal and Anterior Temporal Activations during Successful Retrieval of Memory for Face-Name Associations Peer-reviewed

Takashi Tsukiura, Atsushi Sekiguchi, Yukihito Yomogida, Seishu Nakagawa, Yayoi Shigemune, Toshimune Kambara, Yuko Akitsuki, Yasuyuki Taki, Ryuta Kawashima

JOURNAL OF COGNITIVE NEUROSCIENCE　23　(1)　200-213　2011/01

DOI： 10.1162/jocn.2010.21476 　

ISSN： 0898-929X

eISSN： 1530-8898
Correlation between baseline regional gray matter volume and global gray matter volume decline rate Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Ryoi Goto, Kai Wu, Ryuta Kawashima, Hiroshi Fukuda

NEUROIMAGE　54　(2)　743-749　2011/01

DOI： 10.1016/j.neuroimage.2010.09.071 　

ISSN： 1053-8119
Breakfast Staple Types Affect Brain Gray Matter Volume and Cognitive Function in Healthy Children Peer-reviewed

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Kohei Asano, Ryuta Kawashima

PLOS ONE　5　(12)　e15213　2010/12

DOI： 10.1371/journal.pone.0015213 　

ISSN： 1932-6203
Regional gray matter volume of dopaminergic system associate with creativity: Evidence from voxel-based morphometry Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

NEUROIMAGE　51　(2)　578-585　2010/06

DOI： 10.1016/j.neuroimage.2010.02.078 　

ISSN： 1053-8119
White matter structures associated with creativity: Evidence from diffusion tensor imaging Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Yuko Sassa, Hiroshi Hashizume, Atsushi Sekiguchi, Ai Fukushima, Ryuta Kawashima

NEUROIMAGE　51　(1)　11-18　2010/05

DOI： 10.1016/j.neuroimage.2010.02.035 　

ISSN： 1053-8119
Training of Working Memory Impacts Structural Connectivity Peer-reviewed

Hikaru Takeuchi, Atsushi Sekiguchi, Yasuyuki Taki, Satoru Yokoyama, Yukihito Yomogida, Nozomi Komuro, Tohru Yamanouchi, Shozo Suzuki, Ryuta Kawashima

JOURNAL OF NEUROSCIENCE　30　(9)　3297-3303　2010/03

DOI： 10.1523/JNEUROSCI.4611-09.2010 　

ISSN： 0270-6474
Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study Peer-reviewed

Hashizume Hiroshi, Taki Yasuyuki, Sassa Yuko, Asano Michiko, Asano Kohei, Takeuchi Hikaru, Jeong Hyeonjeong, Sugiura Motoaki, Kawashima Ryuta

NEUROSCIENCE RESEARCH　68　E300-E301　2010

DOI： 10.1016/j.neures.2010.07.1335 　

ISSN： 0168-0102
Age-related differences in brain activity during successful encoding of memory for person identity information Peer-reviewed

Tsukiura T, Shigemune Y, Kambara T, Sekiguchi A, Yomogida Y, Nakagawa S, Akitsuki Y, Taki Y, Kawashima R

Neuroscience research　68　E300　2010

DOI： 10.1016/j.neures.2010.07.1334 　

ISSN： 0168-0102
Effects of Working Memory Training on Cognitive Functions and Neural Systems Peer-reviewed

Hikaru Takeuchi, Yasuyuki Taki, Ryuta Kawashima

REVIEWS IN THE NEUROSCIENCES　21　(6)　427-449　2010

ISSN： 0334-1763
(18)FDG uptake associated with CT density on PET/CT in lungs with and without chronic interstitial lung diseases Peer-reviewed

Kentaro Inoue, Ken Okada, Yasuyuki Taki, Ryoi Goto, Shigeo Kinomura, Hiroshi Fukuda

ANNALS OF NUCLEAR MEDICINE　23　(3)　277-281　2009/05

DOI： 10.1007/s12149-009-0234-8 　

ISSN： 0914-7187
ヒト脳の正常加齢およびその危険因子の解明健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai, 木之村重男, 佐藤和則, 井上健太郎, 後藤了以, 岡田賢, 川島隆太

ナノ医工学年報　2　(1)　89-97　2009/03
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
年齢相応の脳発達とは?

瀧靖之, 橋爪寛, 佐々祐子, 木之村重男, 後藤了以, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会学術集会抄録集　68回　S274-S274　2009/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Normal Brain Aging and its Risk Factors - Analysis of Brain Magnetic Resonance Image (MRI) Database of Healthy Japanese Subjects Peer-reviewed

H. Fukuda, Y. Taki, K. Sato, S. Kinomura, R. Goteau, R. Kawashima

13TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, VOLS 1-3　23　(1-3)　2228-+　2009

ISSN： 1680-0737
Human Cortical Anatomical Networks Assessed by Structural MRI Peer-reviewed

A. C. Evans, J. M. Lee, S. I. Kim, H. Fukuda, R. Kawashima, Y. He, T. Jiang, J. S. Kim, Z. Chen, K. Im, O. Lyttelton, J. Lerch, V. Singh, K. Sato, Y. Taki, R. Goto, S. Kinomura, K. Mok, J. K. Lee, U. Yoon

BRAIN IMAGING AND BEHAVIOR　2　(4)　289-299　2008/12

DOI： 10.1007/s11682-008-9034-3 　

ISSN： 1931-7557

eISSN： 1931-7565
Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly Peer-reviewed

Kentaro Inoue, Hiroshi Ito, Shinya Uchida, Yasuyuki Taki, Shigeo Kinomura, Ichiro Tsuji, Shigeru Sato, Kaoru Horie, Ryuta Kawashima, Masatoshi Ito, Hiroshi Fukuda

HUMAN BRAIN MAPPING　29　(4)　375-384　2008/04

DOI： 10.1002/hbm.20394 　

ISSN： 1065-9471
加齢による灰白質体積の減少は男性が女性よりも早い 382人の脳MRI解析による縦断研究

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　67回　S245-S245　2008/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
ECD SPECTによる脳血流加齢変化の解析

後藤了以, 井上健太郎, 木之村重男, 佐藤和則, 瀧靖之, 岡田賢, 福田寛, 金田朋洋

核医学　45　(1)　46-46　2008/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Relationship between body mass index and gray matter volume in 1,428 healthy individuals Peer-reviewed

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Kentaro Inoue, Ryoi Goto, Ken Okada, Shinya Uchida, Ryuta Kawashima, Hiroshi Fukuda

OBESITY　16　(1)　119-124　2008/01

DOI： 10.1038/oby.2007.4 　

ISSN： 1930-7381
Increase of serum CA19-9 level without an evident lesion on conventional Imaging is insufficient for justification of (18)FDG-PET examination Peer-reviewed

Kentaro Inoue, Ken Okada, Yasuyuki Taki, Ryoi Goto, Shigeo Kinomura, Tomohiro Kaneta, Hiroshi Fukuda

HEPATO-GASTROENTEROLOGY　55　(81)　46-49　2008/01

ISSN： 0172-6390
Diagnosing active inflammation in the SAPHO syndrome using (18)FDG-PET/CT in suspected metastatic vertebral bone tumors Peer-reviewed

Kentaro Inoue, Tatsuo Yamaguchi, Hiroshi Ozawa, Ken Okada, Yasuyuki Taki, Ryoi Goto, Shigeo Kinomura, Tomohiro Kaneta, Hiroshi Fukuda

ANNALS OF NUCLEAR MEDICINE　21　(8)　477-480　2007/10

DOI： 10.1007/s12149-007-0051-x 　

ISSN： 0914-7187
Body Mass Indexと全脳及び局所灰白質量との相関 1428人の脳MR画像を用いたvoxel-based morphometryによる解析

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　43回　S459-S459　2007/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

Radiation Medicine　25　(Suppl.I)　29-29　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043

eISSN： 1862-5274
加齢に伴う脳灰白質体積の経時変化健常被験者の脳MRI解析による8年間の縦断研究(第一報)

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　66回　S187-S187　2007/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

核医学　43　(4)　340-340　2006/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
Diffuse bone marrow uptake on F-18 FDG PET in patients with myelodysplastic syndromes Peer-reviewed

Kentaro Inoue, Ken Okada, Hideo Harigae, Yasuyuki Taki, Ryoi Goto, Shigeo Kinomura, Shunsuke Kato, Tomohiro Kaneta, Hiroshi Fukuda

CLINICAL NUCLEAR MEDICINE　31　(11)　721-723　2006/11

DOI： 10.1097/01.rlu.0000242685.55001.67 　

ISSN： 0363-9762
Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Hiroshi Watabe, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shigeo Kinomura, Shinichiro Osawa, Yoshimi Onishi, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(9)　605-613　2006/11

DOI： 10.1007/BF02984658 　

ISSN： 0914-7187
大脳、小脳の各解剖学的構造における局所灰白質量と年齢との相関 1460人の脳MRIを用いたROI解析

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 小野修一, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　42回　S455-S455　2006/09
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Both global gray matter volume and regional gray matter volume negatively correlate with lifetime alcohol intake in non-alcohol-dependent Japanese men: A volumetric analysis and a voxel-based morphometry Peer-reviewed

Y Taki, S Kinomura, K Sato, R Goto, K Inoue, K Okada, S Ono, R Kawashima, H Fukuda

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH　30　(6)　1045-1050　2006/06

DOI： 10.1111/j.1530-0277.2006.00118.x 　

ISSN： 0145-6008
Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry Peer-reviewed

H Ito, K Inoue, R Goto, S Kinomura, Y Taki, K Okada, K Sato, T Sato, Kanno, I, H Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(2)　131-138　2006/02

DOI： 10.1007/BF02985625 　

ISSN： 0914-7187
Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction Peer-reviewed

K Inoue, H Ito, M Shidahara, R Goto, S Kinomura, K Sato, Y Taki, K Okada, T Kaneda, H Fukuda

ANNALS OF NUCLEAR MEDICINE　20　(2)　139-146　2006/02

DOI： 10.1007/BF02985626 　

ISSN： 0914-7187
Anatomical and functional mapping of the human brain: Japanese brain image database project Peer-reviewed

Hiroshi Fukuda, Shigeo Kinomura, Yasuyuki Taki, Ryo Goto, Kentaro Inoue, Ken Okada, Shinya Uchida, Kazunori Sato, Ryuta Kawashima

FUTURE MEDICAL ENGINEERING BASED ON BIONANOTECHNOLOGY, PROCEEDINGS　635-+　2006
Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: A voxel-based morphometry Peer-reviewed

Y Taki, S Kinomura, S Awata, K Inoue, K Sato, H Ito, R Goto, S Uchida, Tsuji, I, H Arai, R Kawashima, H Fukuda

JOURNAL OF AFFECTIVE DISORDERS　88　(3)　313-320　2005/11

DOI： 10.1016/j.jad.2005.08.003 　

ISSN： 0165-0327
Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography Peer-reviewed

H Ito, M Shidahara, K Inoue, R Goto, S Kinomura, Y Taki, K Okada, T Kaneta, K Sato, T Sato, H Fukuda

ANNALS OF NUCLEAR MEDICINE　19　(4)　251-260　2005/06

ISSN： 0914-7187
What is "normal aging brain for his/her age"?: The first report

Yasuyuki Taki, S. Kinomura, R. Goto, K. Sato, H. Ito, K. Inoue, K. Okada, H. Fukuda, S. Ono, R. Kawashima

Japanese Journal of Clinical Radiology　50　(8)　983-990　2005

ISSN： 0009-9252
A comparison of human observers and a channelized hotelling observer in discriminating between Alzheimer's Dementia and controls using brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shichiro Osawa, Shigeo Kinomura, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

IEEE Nuclear Science Symposium Conference Record　4　2148-2149　2005

DOI： 10.1109/NSSMIC.2005.1596759 　

ISSN： 1095-7863
A comparison of human observers and a channelized hotelling observer in discriminating between Alzheimer's dementia and controls using brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shinichiro Osawa, Shigeo Kinomura, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5　2148-2149　2005

ISSN： 1082-3654
健常高齢者における歯数と脳灰白質容積の関連 A morphometric study

伊藤進太郎, 山口哲史, 高津匡樹, 菊池雅彦, 渡辺誠, 木之村重男, 後藤了以, 井上健太郎, 瀧靖之, 佐藤和則, 福田寛, 辻一郎

日本医学放射線学会雑誌　64　(8)　578-578　2004/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Voxel-based morphometry of human brain with age and cerebrovascular risk factors Peer-reviewed

Y Taki, R Goto, A Evans, A Zijdenbos, P Neelin, J Lerch, K Sato, S Ono, S Kinomura, M Nakagawa, M Sugiura, J Watanabe, R Kawashima, H Fukuda

NEUROBIOLOGY OF AGING　25　(4)　455-463　2004/04

DOI： 10.1016/j.neurobiolaging.2003.09.002 　

ISSN： 0197-4580
皮質下微小梗塞・虚血性病変と皮質灰白質容積変化の関連

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会雑誌　63　(9)　596-597　2003/11
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
Neuroanatomical database of normal Japanese brains Peer-reviewed

K Sato, Y Taki, H Fukuda, R Kawashima

NEURAL NETWORKS　16　(9)　1301-1310　2003/11

DOI： 10.1016/j.neunet.2003.06.004 　

ISSN： 0893-6080
ヒトの脳における加齢,脳血管危険因子と灰白質,白質の形態変化との相関

瀧靖之, 川島隆太, 後藤了以, 佐藤和則, 小野修一, 木之村重男, 中川学, 杉浦元亮, 渡辺丈夫, 福田寛

加齢医学研究所雑誌　54　(1～2)　50-50　2003/03
Publisher: 東北大学加齢医学研究所
ISSN： 1340-3397
脳血流SPECTカウントは脳灰白質密度を反映するか?

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 川島隆太, 福田寛

核医学　39　(3)　377-377　2002/09
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
臨床用MR画像による脳組織容積計測

木之村重男, 小野修一, 後藤了以, 井上健太郎, 中川学, 杉浦元亮, 岡田賢, 瀧靖之, 渡邊丈夫, 佐藤和則

日本医学放射線学会雑誌　62　(6)　299-299　2002/05
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428

eISSN： 1347-7951
脳萎縮に関わる危険因子 MR画像による解析

瀧靖之, 川島隆太, 小野修一, 木之村重男, 後藤了以, 佐藤和則, 福田寛

加齢医学研究所雑誌　53　(1～2)　15-15　2002/02
Publisher: 東北大学加齢医学研究所
ISSN： 1340-3397

Show all ︎Show first 5

Misc. 180

Relationship between brain volume and myopia in glaucoma patients using MRI

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　128　2024

ISSN： 0029-0203
In vitroオートラジオグラフィーによる[18F]SMBT-1 PETの妥当性の検証

工藤楓, 原田龍一, 工藤幸司, 瀧靖之, 田代学, 古本祥三, 岡村信行

JSMI Report　16　(2)　71-71　2023/05
Publisher: 日本分子イメージング学会
ISSN： 1882-6490
2.5次元写真が主観的幸福感と睡眠の質に及ぼす影響

高岡祥子, 高野裕治, 瀧靖之

日本心理学会大会発表論文集　86回　804-804　2023/03
Publisher: (公社)日本心理学会
eISSN： 2433-7609
アルツハイマー型認知症の臨床症状における大脳皮質および白質病変の関与についての検討

中瀬泰然, 舘脇康子, 冨田尚希, 村中美千帆, 高野由美, 山本修三, 瀧靖之

日本内科学会雑誌　112　(臨増)　160-160　2023/02
Publisher: (一社)日本内科学会
ISSN： 0021-5384

eISSN： 1883-2083
MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

村中美千帆, 舘脇康子, Benjamin Thyreau, 阪本真弥, 高野由美, 山本修三, 冨田尚希, 中瀬泰然, 瀧靖之

老年精神医学雑誌　33　(増刊II)　265-265　2022/11
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

中瀬泰然, 冨田尚希, 舘脇康子, 高野由美, 村中美千帆, 山本修三, 瀧靖之

老年精神医学雑誌　33　(増刊II)　288-288　2022/11
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討

武田研, 舘脇康子, Benjamin Thyeau, 村中美千帆, 阪本真弥, 二宮利治, 瀧靖之

老年精神医学雑誌　33　(増刊II)　304-305　2022/11
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
MRI画像を用いて測定した咬筋断面積と物忘れ患者の認知機能の相関に関する検討

村中美千帆, 舘脇慶子, Benjamin Thyreau, 阪本真弥, 高野由美, 山本修三, 冨田尚希, 中瀬泰然, 瀧靖之

Dementia Japan　36　(4)　761-761　2022/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
アルツハイマー型認知症周辺症状に対する各種治療薬の効果についての検討

中瀬泰然, 冨田尚希, 舘脇康子, 高野由美, 村中美千帆, 山本修三, 瀧靖之

Dementia Japan　36　(4)　771-771　2022/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討

武田研, 舘脇康子, Benjamin Thyreau, 村中美千帆, 阪本真弥, 二宮利治, 瀧靖之

Dementia Japan　36　(4)　779-779　2022/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
コロナワクチン接種後に多臓器の障害が見られた高齢認知症の1例

村中美千帆, 冨田尚希, 中瀬泰然, 高野由美, 山本修三, 舘脇康子, 武藤達士, 瀧靖之

日本老年医学会雑誌　59　(4)　574-574　2022/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
ポリファーマシー対策目的に入院し,薬物療法適正化に成功した1例

高橋麻由子, 冨田尚希, 山田稜, 武藤理恵, 黒澤桂子, 鈴木寿樹, 松浦正樹, 武藤達士, 瀧靖之, 眞野成康

日本老年医学会雑誌　59　(4)　575-575　2022/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
【新規MRI計測・解析技術の認知症への応用】アルツハイマー病の一次、二次予防を目指した新規MRI計測技術とその応用

瀧靖之

Dementia Japan　36　(3)　423-429　2022/09
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
緑内障患者の眼科指標と脳海馬体積との関連に関する検討

山田晃生, 舘脇康子, 面高宗子, 松平泉, Benjamin Thyreau, 瀧靖之, 中澤徹

日本緑内障学会抄録集　33回　86-86　2022/09
Publisher: 日本緑内障学会
CADi2を用いて測定した認知機能と緑内障性視野障害重症度の関連性

佐藤正隆, 山田晃生, 清田直樹, 津田聡, 大木広美, 吉田光秀, 冨田尚希, 國方彦志, 瀧靖之, 中澤徹

日本緑内障学会抄録集　33回　88-88　2022/09
Publisher: 日本緑内障学会
高齢者における循環器疾患に対する応用薬理慢性心不全患者における脳由来成長因子(BDNF)と脳灰白質量との関連慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2)

鈴木秀明, 松本泰治, 大田英揮, 杉村宏一郎, 後岡広太郎, 高橋潤, 宮田敏, 古川勝敏, 福本義弘, 瀧靖之, 下川宏明, 安田聡

応用薬理　102　(5-6)　123-123　2022/08
Publisher: 応用薬理研究会
ISSN： 0300-8533
高齢者における循環器疾患に対する応用薬理慢性心不全患者における脳由来成長因子(BDNF)と脳灰白質量との関連慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2)

鈴木秀明, 松本泰治, 大田英揮, 杉村宏一郎, 後岡広太郎, 高橋潤, 宮田敏, 古川勝敏, 福本義弘, 瀧靖之, 下川宏明, 安田聡

応用薬理　102　(5-6)　123-123　2022/08
Publisher: 応用薬理研究会
ISSN： 0300-8533
【あなたはAI好きですか?】BrainSuite(ブレーンスイート) 脳ドック等で簡便に利用できるAI画像解析サービスの紹介

樋口彰, Thyreau Benjamin, 瀧靖之

Rad Fan　20　(7)　45-48　2022/06
Publisher: (株)メディカルアイ
ISSN： 1348-3498
高齢者総合機能評価に適した聴覚スクリーニング測定用アプリケーションの開発

冨田尚希, 佐藤剛史, 本蔵陽平, 鈴木淳, 香取幸夫, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　116-116　2022/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
【加齢医学における画像診断超高齢社会に求められる画像診断・検査のノウハウ】画像診療の高齢者への最適化効果的な検査法と診断法の実践

舘脇康子, 瀧靖之

INNERVISION　37　(6)　12-15　2022/05
Publisher: (株)インナービジョン
ISSN： 0913-8919
アルツハイマー型認知症の進行に影響する心房細動についての検討

中瀬泰然, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　104-104　2022/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
高齢者総合機能評価に適した聴覚スクリーニング測定用アプリケーションの開発

冨田尚希, 佐藤剛史, 本蔵陽平, 鈴木淳, 香取幸夫, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　116-116　2022/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
物忘れの自覚に関わる因子の検討

張よう, 冨田尚希, 中瀬泰然, 瀧靖之

日本老年医学会雑誌　59　(Suppl.)　133-133　2022/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
MRIを用いた緑内障患者の経時的な脳構造変化の検討。

山田晃生, 面高宗子, 舘脇康子, 松平泉, 瀧靖之, 中澤徹

日本眼科学会雑誌　126　(臨増)　272-272　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
大規模脳画像データベースから見る脳の発達と加齢

瀧靖之

総合健診　49　(1)　96-96　2022/01
Publisher: (一社)日本総合健診医学会
ISSN： 1347-0086

eISSN： 1884-4103
【生活様式の変化から考える子どもの感覚器と口腔機能】小児の脳発達とインターネットの利用習慣が小児の脳に及ぼす影響

瀧靖之

子どもと発育発達　19　(4)　254-258　2022/01
Publisher: 日本発育発達学会
ISSN： 1348-3056
【神経疾患を克服する-わが国の戦略(2)】研究手法の最新の話題認知症の一次予防、二次予防を目指した最新MRI画像解析 AIとモルフォロジー解析の活用

舘脇康子, 瀧靖之

Clinical Neuroscience　39　(10)　1250-1253　2021/10
Publisher: (株)中外医学社
ISSN： 0289-0585
新規MRI計測・解析技術の認知症への応用アルツハイマー病の一次、二次予防を目指した新規MRI計測技術とその応用

瀧靖之

Dementia Japan　35　(4)　577-577　2021/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
アルツハイマー病の進行に関与する便秘の影響についての検討

中瀬泰然, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

Dementia Japan　35　(4)　614-614　2021/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
認知症病態に関わる心房細動の影響についての検討

中瀬泰然, 竹石潤平, 舘脇康子, Benjamin Thyreau, 武藤達士, 冨田尚希, 山本修三, 高野由美, 村中美千帆, 瀧靖之

Dementia Japan　35　(4)　620-620　2021/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
都市在住高齢者の認知機能の性差および側頭葉体積との関連

文鐘玉, 新村秀人, 喜田恒, 鈴木航太, 色本涼, 三村將, 瀧靖之

Dementia Japan　35　(4)　630-630　2021/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
認知症診療における老老介護を考察する

石木愛子, 田中陽子, 冨田尚希, 高野由美, 山本修三, 舘脇康子, 沼崎宗夫, 武藤達士, 瀧靖之, 荒井啓行

日本老年医学会雑誌　58　(4)　643-643　2021/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
脳ドックへの新しい手法の応用脳画像データベースに基づく認知症予防知見とAI脳画像解析技術の脳ドック診療への実装

瀧靖之

日本脳ドック学会報　7　(2)　17-21　2021/09
Publisher: (一社)日本脳ドック学会
ISSN： 2189-3128

eISSN： 2758-3821
【Step up MRI 2021 MRIにおけるAIの最新動向とISMRMに見る研究の最前線】MRIにおけるAIの研究開発・臨床応用の最新動向 6.画像解析AI技術を用いた脳ドック用プログラムの開発と将来展望

樋口彰, 瀧靖之

INNERVISION　36　(9)　24-27　2021/08
Publisher: (株)インナービジョン
ISSN： 0913-8919
地域高齢者における尿中アルブミンと脳萎縮・大脳白質病変の関連 JPSC-AD研究

山崎景介, 秦淳, 小原知之, 柴田舞欧, 古田芳彦, 平林直樹, 瀧靖之, 二宮利治

日本腎臓学会誌　63　(4)　425-425　2021/06
Publisher: (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
老年科専門医育成の今後老年科専門医が持つべき能力・理念

冨田尚希, 村中美千帆, 高野由美, 館脇康子, 山本修三, 中瀬泰然, 武藤達士, 瀧靖之

日本老年医学会雑誌　58　(Suppl.)　89-89　2021/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
MR位相情報を利用した簡便な認知機能検査法

米田哲也, 田中隆太郎, 瀧石龍太, 安里桃花, 安本のぞみ, 館脇康子, 瀧靖之

JSMI Report　14　(2)　116-116　2021/05
Publisher: 日本分子イメージング学会
ISSN： 1882-6490
睡眠習慣の相違によるうつ状態と慢性疲労との弁別

中川誠秀, 中川誠秀, 竹内光, 瀧靖之, 野内類, 関口敦, 宮内誠カルロス, 飯塚邦夫, 横山諒一, 塙杉子, 榊浩平, ジョンビヨンジョン, ジョンビヨンジョン, 川島隆太

日本うつ病学会総会プログラム・抄録集　17th　2021
Connectome Prediction Model for representation of individual cognitive functions

小川剛史, 竹内光, 池田純起, 瀧靖之, 野内類, 横山諒一, 事崎由佳, 中川誠秀, 関口敦, 飯塚邦夫, 塙杉子, 荒木剛, 宮内カルロス誠, 榊浩平, 佐々祐子, 野澤孝之, 横田晋, MAGISTROP Daniele, 川島隆太

電子情報通信学会大会講演論文集(CD-ROM)　2021　2021

ISSN： 1349-144X
【2025年問題を見据えたエージング研究と医薬品開発】大規模脳画像データベースから見る脳の発達と加齢、認知症予防

瀧靖之

ファルマシア　56　(11)　1014-1016　2020/11
Publisher: (公社)日本薬学会
ISSN： 0014-8601

eISSN： 2189-7026
薬剤性collagenous colitisと診断された自験2症例の報告と考察

冲永壯治, 石木愛子, 冨田尚希, 沼崎宗夫, 國時景子, 高野由美, 山本修三, 武藤達士, 瀧靖之, 荒井啓行

日本老年医学会雑誌　57　(4)　497-497　2020/10
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
ヒト頭蓋のサイズおよび形態のゲノムワイド関連解析

座間味夏帆, 木村亮介, 石田肇, 瀧靖之, 竹内光, Thyreau Benjamin, 今西規

琉球医学会誌　39　(1-4)　95-95　2020
Publisher: 琉球医学会
ISSN： 1346-888X
規範的な養育と子どもの脳の発達

松平泉, 瀧靖之

周産期医学　49　(12)　2019/12
高齢女性の骨量減少とアルツハイマー型認知症の脳血流低下領域との関係

関俊樹, 武藤達士, 高野由美, 山本修三, 舘脇康子, 荒井啓行, 瀧靖之

Dementia Japan　33　(4)　553-553　2019/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
発達からみた脳の形態的変化

松平泉, 瀧靖之

小児内科　51　(3)　2019/03
MRIを用いた緑内障患者の眼球形態の検討

國時景子, 國時景子, 舘脇康子, 面高宗子, 松平泉, THYREAU Benjamin, 武藤達士, 川島隆太, 中澤徹, 瀧靖之, 瀧靖之

日本疫学会学術総会講演集(Web)　29th　2019
オリゴデンドロサイト関連遺伝子多型(rs1059004)と自己スキーマ及び抑うつ症状との相関研究

小松浩, 小松浩, 竹内光, 菊地淑恵, 小野千晶, 兪志前, 兪志前, 飯塚邦夫, 角藤芳久, 舩越俊一, 舩越俊一, 大野高志, 川島隆太, 川島隆太, 川島隆太, 瀧靖之, 瀧靖之, 瀧靖之, 富田博秋, 富田博秋, 富田博秋, 富田博秋

日本うつ病学会総会プログラム・抄録集　16th　2019
3D-CNNを用いた脳MRI画像からの年齢推定手法とその性能評価—メディア工学 ; サマーセミナー2018 : ひろがるビジョン技術の実利用

上田大, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

映像情報メディア学会技術報告 = ITE technical report　42　(27)　27-30　2018/08
Publisher: 東京 : 映像情報メディア学会
ISSN： 1342-6893
Imaging Features of the Normal Aging Brain

舘脇康子, 舘脇康子, 瀧靖之, 瀧靖之

画像診断　38　(9)　866‐878　2018/07/25

ISSN： 0285-0524
OLIG2遺伝子多型(rs1059004)と統合失調症との関連、白質統合性、安静時脳灌流量及び認知機能への影響の検討

小松浩, 竹内光, 菊地淑恵, 小野千晶, 角藤芳久, 舩越俊一, 大野高志, 山森秀長, 安田由華, 藤本美智子, 畦地裕統, 工藤紀子, 川島隆太, 橋本亮太, 瀧靖之, 富田博秋

精神神経学雑誌　(2018特別号)　S656-S656　2018/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
MRI平均拡散率を用いた集団主義の神経基盤の同定

中川誠秀, 竹内光, 瀧靖之, 瀧靖之, 野内類, 野内類, 事崎由佳, 品田貴光, 丸山司, 関口敦, 関口敦, 飯塚邦夫, 横山諒一, 山本悠貴, 塙杉子, 荒木剛, 宮内誠カルロス, MAGISTRO Daniele, 榊浩平, 鄭嫣てい, 鄭嫣てい, 佐々木結咲子, 川島隆太

日本精神神経学会総会プログラム・抄録集　114th　(2018特別号)　S655-S655　2018/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
脳の定型発達と非定型発達

松平泉, 瀧靖之

小児科　59　(6)　855-862　2018/05
評価法と検査法認知症のMRI診断(VSRADを含む)

舘脇康子, 舘脇康子, 瀧靖之

日本臨床　76　16‐23　2018/01/20

ISSN： 0047-1852
Performance Evaluation of Age Estimation Methods Using ADNI Database-Comparison of Brain Local Features and CNN-

伊藤康一, 藤本竜一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電子情報通信学会技術研究報告　117　(518(MI2017 63-106))　2018

ISSN： 0913-5685
3D-CNNを用いた脳MRI画像からの年齢推定手法とその性能評価

上田大, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

映像情報メディア学会技術報告　42　(27(ME2018 75-98))　2018

ISSN： 1342-6893
A Study of an Age Estimation Method From Brain MRI Images Using 3D-CNN and Its Application

上田大, 伊藤康一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電子情報通信学会技術研究報告　118　(286(MI2018 38-58)(Web))　2018

ISSN： 0913-5685
視放線における緑内障性神経変化のDTI-NODDIによる検出

山田晃生, 面高宗子, 舘脇康子, 松平泉, 下地啓五, 齊藤麻美, 川島隆太, 瀧靖之, 中澤徹

日本緑内障学会抄録集　29th　2018
IMPACT OF OLIG2 GENE VARIANT (RS1059004) ON WHITE MATTER TRACT INTEGRITY AND MEAN CEREBRAL BLOOD FLOW OF THE HUMAN BRAIN

Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Akira Kodaka, Shunichi Funakoshi, Takashi Ono, Yoshihisa Kakuto, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

EUROPEAN NEUROPSYCHOPHARMACOLOGY　27　S315-S316　2017/10

ISSN： 0924-977X

eISSN： 1873-7862
小脳失調と認知機能障害が主症状であった進行性核上性麻痺(PSP-C)の1例

北村佑樹, 戸恒智子, 武藤達士, 冨田尚希, 石木愛子, 國時景子, 舘脇康子, 中川学, 沼崎宗夫, 冲永壯治, 瀧靖之, 荒井啓行

Dementia Japan　31　(4)　593-593　2017/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
難聴が診断の妨げとなったLogopenic型失語を呈するアルツハイマー型認知症の一例

國時景子, 舘脇康子, 戸恒智子, 石木愛子, 富田尚希, 中川学, 沼崎宗夫, 沖永壯治, 武藤達士, 瀧靖之, 荒井啓行

Dementia Japan　31　(4)　609-609　2017/10
Publisher: (一社)日本認知症学会
ISSN： 1342-646X
乳がん手術前後の脳構造変化および認知機能障害縦断研究による検討

佐藤千穂, 関口敦, 事崎由佳, 野内類, 竹内光, 瀧靖之, 河合賢朗, 多田寛, 石田孝宣, 川島隆太, 大内憲明

心身医学　57　(7)　761-761　2017/07
Publisher: (一社)日本心身医学会
ISSN： 0385-0307
沿岸部被災地在住の高齢女性たちに対する園芸療法介入の効果の検証

事崎由佳, 竹内光, 関口敦, 荒木剛, 山本悠貴, 品田貴光, Magistro Daniele, 十亀彩, 瀧靖之, 川島隆太

心身医学　57　(7)　761-762　2017/07
Publisher: (一社)日本心身医学会
ISSN： 0385-0307
An Age Estimation Method Using Brain Local Features of Brain MRI Images and Its Performance Evaluation

117　(47)　67-70　2017/05/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
Normal database construction of dopamine transporter SPECT in Japan

Hiroshi Matsuda, Norihide Maikusa, Etsuko Imabayashi, Masayo Ogawa, Miho Murata, Shigeki Hirano, Kazuya Sako, Yasuyuki Taki, Kenjiro Ono, Hiroshi Toyama, Atsushi Kono, Hiroshi Nagayama

JOURNAL OF NUCLEAR MEDICINE　58　2017/05

ISSN： 0161-5505

eISSN： 1535-5667
PRE-EXISTING SMALLER DLPFC VOLUME CONTRIBUTES TO POST-TRAUMATIC GROWTH AFTER A DISASTER IN CHILDREN

Atsushi Sekiguchi, Yuka Kotozaki, Thyreau Benjamin, Hikaru Takeuchi, Susumu Yokota, Kohei Asano, Michiko Asano, Yuko Sassa, Yasuyuki Taki, Ryuta Kawashima

PSYCHOSOMATIC MEDICINE　79　(4)　A60-A61　2017/05

ISSN： 0033-3174

eISSN： 1534-7796
MRIにおける広範な脳視覚野の緑内障性変化と部位間の相関

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本眼科学会雑誌　121　225　2017/03/08

ISSN： 0029-0203
アルツハイマー病のための脳局所特徴量を用いたMR画像解析に関する検討

藤本竜一, 伊藤康一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

日本医用画像工学会大会予稿集(CD-ROM)　36th　2017

ISSN： 0288-450X
緑内障患者におけるMRIの視覚野体積と視野重症度との関連

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 瀧靖之, 中澤徹

日本緑内障学会抄録集　28th　2017
大規模ゲノムバンクiJGVDを用いた放射線感受性遺伝子変異の検討と個別化放射線被ばくリスク評価

福永久典, 福永久典, 福永久典, 横谷明徳, 瀧靖之

アイソトープ・放射線研究発表会要旨集　54th　2017
Microcirculatory velocity estimation with radon transformation for confocal laser scanning microscopic image

中村和浩, 中村和浩, 武藤達士, 武藤達士, 佐々木一益, 佐々木一益, 瀧靖之, 石川達哉

電子情報通信学会技術研究報告　116　(520(MBE2016 82-102))　2017

ISSN： 0913-5685
MODELING TO INDIVIDUALIZE MEAN ARTERIAL PRESSURE THRESHOLD TO PREVENT ACUTE KIDNEY INJURY IN THE ICU

Kazumasu Sasaki, Tatsushi Mutoh, Tomoko Mutoh, Yasuyuki Taki, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　44　(12)　2016/12

ISSN： 0090-3493

eISSN： 1530-0293
DETECTION OF EARLY BRAIN INJURY AND RISK FOR DCI USING 3D-SSP CBF ANALYSIS IN PATIENTS AFTER SAH

Tatsushi Mutoh, Tomoko Mutoh, Kazumasu Sasaki, Yasuyuki Taki, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　44　(12)　2016/12

ISSN： 0090-3493

eISSN： 1530-0293
REVERSAL OF MICROVASCULAR DYSFUNCTION BY NEUROPROTECTIVE HYPERDYNAMIC THERAPY FOR POST-SAH VASOSPASM

Tatsushi Mutoh, Kazumasu Sasaki, Kazuhiro Nakamura, Tomoko Mutoh, Yasuyuki Taki, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　44　(12)　2016/12

ISSN： 0090-3493

eISSN： 1530-0293
Reversal of Post-stroke Cerebral Microvascular Dysfunction by Neuroprotective and Hyperdynamic Therapy for Experimental Subarachnoid Hemorrhage

Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Kazuhiro Nakamura, Yasuyuki Taki, Tatsuya Ishikawa

CIRCULATION　134　2016/11

ISSN： 0009-7322

eISSN： 1524-4539
ファントムを用いたイオフルパンSPECT定量値の機種間補正

松田博史, 今林悦子, 村田美穂, 佐光一也, 瀧靖之, 平野成樹, 永山寛, 小野賢二郎, 外山宏, 河野淳

核医学　53　(Suppl.)　S285-S285　2016/10
Publisher: (一社)日本核医学会
ISSN： 0022-7854
Brain development using MRI database in healthy children

Taki Yasuyuki

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY　108　4-5　2016/10

DOI： 10.1016/j.ijpsycho.2016.07.013 　

ISSN： 0167-8760

eISSN： 1872-7697
脳局所特徴量を用いた年齢推定とその高精度化に関する検討 (メディア工学) -- (サマーセミナー2016 : 世界を視る・世界を創るビジョン技術)

藤本竜一, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

映像情報メディア学会技術報告 = ITE technical report　40　(28)　31-34　2016/08
Publisher: 映像情報メディア学会
ISSN： 1342-6893
A Study of an Efficient Method of Selecting Effective Brain Local Features for Age Estimation

116　(160)　13-18　2016/07/25
Publisher: 電子情報通信学会
ISSN： 0913-5685
神経性やせ症患者の放線冠前部における白質線維統合性の低下

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 橋爪寛, 遠藤由香, 庄司知隆, 田村太作, 町田知美, 町田貴胤, 河内山隆紀, 瀧靖之, 川島隆太, 福土審, 福土審

東北医学雑誌　128　(1)　64‐65　2016/06/25

ISSN： 0040-8700
Association between mu-opioid receptor gene variant 118 A > G and personality traits among Japanese population

Yumiko Kubo, Hikaru Takeuchi, Yoshie Kikuchi, Yoshiyuki Kasahara, Zhiqian Yu, Yasuyuki Taki, Ryuta Kawashima, Hiroaki Tomita

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　299-300　2016/06

ISSN： 1461-1457

eISSN： 1469-5111
Brain image findings of the elderly

144　(11)　2235-2239　2016/02
Publisher: 日本医師会
ISSN： 0021-4493
重症度と全身合併症に応じたくも膜下出血の遅発性脳虚血に対する血行動態モニタリングの有用性

武藤達士, 石川達哉, 数又研, 寺坂俊介, 瀧靖之, 安井信之, 鈴木明文

脳血管攣縮　31　88-89　2016/02
Publisher: スパズム・シンポジウム事務局
ISSN： 0912-7070
部分容積効果補正法を用いたband heterotopia症例における異所性灰白質の血流・代謝評価の試み

荒井晃, 森下陽平, 高浪健太郎, 麦倉俊司, 高瀬圭, 瀧靖之

核医学　53　(1)　503-503　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854
心嚢液貯留に集積亢進を認めたFDG-PET/CTの1例

福永久典, 下村英雄, 館脇康子, 寺尾千秋, 戸恒智子, 阿部十也, 武藤達士, 瀧靖之, 荒井晃, 高波健太郎, 高瀬圭

核医学　53　(1)　567　2016/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
負荷心筋シンチグラフィにおける安静時でのSPECT収集時間の検討

竹内孝至, 小田桐逸人, 伊藤大輔, 渡邊紀久子, 杉山周平, 梁川功, 瀧靖之

日本放射線技術学会東北部会雑誌　(25)　186-186　2016/01
Publisher: (公社)日本放射線技術学会-東北支部
線条体イメージングにおける脳の萎縮や脳室の拡大がSBRに及ぼす影響の検討

斎藤拓真, 小田桐逸人, 伊藤大輔, 梁川功, 下村英雄, 瀧靖之, 馬場徹, 森悦朗

日本放射線技術学会東北部会雑誌　(25)　191-191　2016/01
Publisher: (公社)日本放射線技術学会-東北支部
標準脳への変換を用いた線条体イメージング解析の検討

杉山周平, 小田桐逸人, 大場健太郎, 瀧靖之

日本放射線技術学会東北部会雑誌　(25)　192-192　2016/01
Publisher: (公社)日本放射線技術学会-東北支部
MRIにおける眼窩内視神経断面積の緑内障性変化

福田麻奈, 面高宗子, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
MRIにおける脳一次視覚野の緑内障性変化

面高宗子, 福田麻奈, 舘脇康子, 檜森紀子, 松平泉, 村田隆紀, 瀧靖之, 中澤徹

日本緑内障学会抄録集　27th　96　2016
SPECT/CT装置を用いた手動ROI法による123I-MIBGシンチグラフィの精度向上に関する検討

小田桐逸人, 馬場徹, 飯塚統, 西尾慶之, 松田実, 井上健太郎, 瀧靖之, 森悦朗

パーキンソン病・運動障害疾患コングレスプログラム・抄録集　9回　75-75　2015/10
Publisher: Movement Disorder Society of Japan (MDSJ)
G-001 Selection of behavioral score for subarachnoid hemorrhage mouse in animal video monitor system

Nakamura Kazuhiro, Mutoh Tatsushi, Sasaki Kazumasu, Taki Yasuyuki, Ishikawa Tatsuya

14　(2)　371-372　2015/08/24
Publisher: Forum on Information Technology
The relationship between Serum Isoflavone Level and Brain Volume/Cognitive Function in Elderly Subjects

辻一郎, 遠又靖丈, THYREAU Benjamin, 瀧靖之, 瀧靖之, 渡邉崇, 杉山賢明, 小暮真奈, CHOU Wan‐Ting, 本蔵賢治, 海法悠, 松尾兼幸, 菅原由美, 曽根稔雅, 曽根稔雅, 高橋英子, 柿崎真沙子, 相田潤

大豆たん白質研究　17　90-94　2015/06

ISSN： 1344-4050
脳MRI画像の局所特徴量に基づく年齢推定手法と縦断データベースを用いた性能評価

近藤, 千裕, 伊藤, 康一, 呉, 凱, 佐藤, 和則, 瀧, 靖之, 福田, 寛, 青木, 孝文

第77回全国大会講演論文集　2015　(1)　359-360　2015/03/17

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大規模な脳 MRI 画像データベースを用いた統計解析を通して，加齢に伴って脳組織が萎縮することが知られている．この結果を利用することで，正常加齢に伴う脳の形態変化から年齢を推定することができる．推定された年齢と実年齢を比較することで，脳疾患の早期発見や診断支援を行うことが可能となる．そこで，本稿では，解剖学的意味を持つ 90 領域に分割した脳組織の体積を特徴量として脳 MRI 画像から年齢を推定する手法を提案する．脳形態に個人差があるため，正確に実年齢を推定することが難しい．これに対して，本稿では，縦断データを用いた年齢推定実験を通して，実際の撮像間隔と推定された撮像間隔を比較することで，提案手法の有効性を示す．
Performance Evaluation of an Age Estimation Method Using Longitudinal Brain MRI Database

KONDO Chihiro, ITO Koichi, WU Kai, SATO Kazunori, TAKI Yasuyuki, FUKUDA Hiroshi, AOKI Takafumi

IEICE technical report.　114　(482)　23-28　2015/03/02
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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It is well known that brain tissues have age-related morphological changes through a set of statistical analysis using large-scale brain MRI image databases. This fact allows us to estimate the age of a subject from brain MRI images by evaluating brain morphological changes with healthy aging. This paper proposes an age estimation method using local features extracted from T1-weighted MRI images. Individual differences in brain structure make it difficult to evaluate performance of age estimation methods. Therefore, we use a longitudinal T1-weighted MRI dataset and evaluate performance of the proposed method by estimated elapsed years.
Intensive Monitoring of Cardiac Function and Extravascular Lung Water Predicts Outcome of Tako-tsubo Cardiomyopathy after Subarachnoid Hemorrhage

Tatsushi Mutoh, Ken Kazumata, Yasuyuki Taki, Kentaro Inoue, Akifumi Suzuki, Tatsuya Ishikawa

STROKE　46　2015/02

ISSN： 0039-2499

eISSN： 1524-4628
voxel based morphometry(VBM)を用いた緑内障における脳視路変性の検討

舘脇康子, 村田隆紀, 麦倉俊司, 高橋昭喜, 瀧靖之, 関口敦, 面高宗子, 中澤徹

Japanese Journal of Radiology　33　(Suppl.)　9-9　2015/02
Publisher: (公社)日本医学放射線学会
ISSN： 1867-1071
脳MRI画像の局所特徴量に基づく年齢推定手法と縦断データベースを用いた性能評価

近藤千裕, 伊藤康一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

情報処理学会全国大会講演論文集　77th　(2)　2015
An Age Estimation Method Using Local Features of Brain MRI Images and Its Performance Evaluation Using the ADNI Database

近藤千裕, 伊藤康一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電子情報通信学会技術研究報告　115　(139(MI2015 32-47))　2015

ISSN： 0913-5685
A Study of an Analysis of Structural Brain Network of the ADNI Database

近藤千裕, 伊藤康一, WU Kai, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

電子情報通信学会技術研究報告　115　(301(MI2015 57-72))　2015

ISSN： 0913-5685
SPECT収集距離の違いがコリメータ開口径補正に与える影響について

川畑朋桂, 小田桐逸人, 伊藤大輔, 渡邊紀久子, 森隆一, 杉山周平, 堀口優美, 梁川功, 瀧靖之

日本放射線技術学会東北部会雑誌　(24)　120-120　2015/01
Publisher: (公社)日本放射線技術学会-東北支部
呼吸同期システムを用いた肺血流SPECT撮影の試み

堀口優美, 小田桐逸人, 伊藤大輔, 渡邊紀久子, 森隆一, 川畑朋桂, 杉山周平, 梁川功, 瀧靖之

日本放射線技術学会東北部会雑誌　(24)　155-155　2015/01
Publisher: (公社)日本放射線技術学会-東北支部
くも膜下出血モデル動物に関するMRI画像評価方法の検討

中村和浩, 中村和浩, 武藤達士, 武藤達士, 佐々木一益, 瀧靖之, 石川達哉

日本脳循環代謝学会総会プログラム・抄録号　27th　2015

ISSN： 0915-9401
Longitudinal Brain Development and Aging Studies Using Large Brain MRI Database

TAKI Yasuyuki

Med Imag Tech　33　(1)　3-6　2015
Publisher: The Japanese Society of Medical Imaging Technology
DOI： 10.11409/mit.33.3 　

ISSN： 0288-450X

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Now we confront a super aging society in Japan. In the situation, it is important to preserve our cognitive function for entire life by preventing us from pathological brain aging. To perform the aim, we have built a large brain magnetic resonance imaging (MRI) database from around 3000 subjects aged from five to 80 in order to reveal how brain develops and ages with not only cross-sectional but longitudinal designs. We have also collected several cognitive functions, lifestyle such as eating and sleeping habits, and genetic data. Using the database, we have revealed normal brain development and aging, and also have revealed what factors affect brain development and aging. In performing these analyses, longitudinal analysis is very important, for we can reduce the influences of inter-individual variability of several factors such as differences of brain shapes. These findings help understanding the mechanism of brain development and aging as well as performing differential diagnosis or diagnosis at an early stage of several diseases/disorders such as autism and Alzheimer's disease.
CARDIAC FUNCTION INDEX PREDICTS OUTCOME OF TAKOTSUBO CARDIOMYOPATHY AFTER SUBARACHNOID HEMORRHAGE

Tatsushi Mutoh, Ken Kazumata, Yasuyuki Taki, Kentaro Inoue, Akifumi Suzuki, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　42　(12)　2014/12

ISSN： 0090-3493

eISSN： 1530-0293
HEMODYNAMIC SLOPE PLAYS A KEY ROLE IN REVERSING CLINICAL VASOSPASM AFTER SUBARACHNOID HEMORRHAGE

Tatsushi Mutoh, Yasuyuki Taki, Kentaro Inoue, Akifumi Suzuki, Tatsuya Ishikawa

CRITICAL CARE MEDICINE　42　(12)　2014/12

ISSN： 0090-3493

eISSN： 1530-0293
An Age Estimation Method Using Local Features of Brain MRI Images and Its Evaluation

KONDO Chihiro, ITO Koichi, WU Kai, SATO Kazunori, TAKI Yasuyuki, FUKUDA Hiroshi, AOKl Takafumi

IEICE technical report.　114　(311)　11-16　2014/11/11
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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It is well known that brain tissues have age-related morphological changes through a set of statistical analysis using large-scale brain MRI image databases. This fact allows us to estimate the age of a subject from brain MRI images by evaluating brain morphological changes with healthy aging. This paper proposes an age estimation method using local features extracted from T1-weighted MRI images. The brain local features are defined by volumes of brain tissues separated into 90 local regions denned by the Automated Anatomical Labeling atlas. We evaluate performance of the proposed method using 1,146 T1-weighted MRI images from the Aoba Brain Imaging Project and the Tsurugaya Project. We also analyze effectiveness of each local region for age estimation and discuss its medical implication.
Real-Time Hemodynamic and Volumetric Monitoring in Patients With Takotsubo Cardiomyopathy After Subarachnoid Hemorrhage

Tatsushi Mutoh, Tatsuya Ishikawa, Yasuyuki Taki, Akifumi Suzuki

CIRCULATION　130　2014/11

ISSN： 0009-7322

eISSN： 1524-4539
被災地健康調査における家庭血圧計診断に基づく高血圧症の実態

清元秀泰, 寳澤篤, 田中由香利, 奥田拓史, 菅原準一, 坪井明人, 布施昇男, 栗山進一, 瀧靖之, 辻一郎, 阿部倫明, 高井貴子, 八重樫伸生, 山本雅之, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　37回　442-442　2014/10
Publisher: (NPO)日本高血圧学会
心臓専用多焦点コリメーターにおける心尖部高集積の影響

森隆一, 小田桐逸人, 伊藤大輔, 渡邊紀久子, 杉山周平, 梁川功, 高浪健太郎, 瀧靖之

日本放射線技術学会雑誌　70　(9)　976-976　2014/09
Publisher: (公社)日本放射線技術学会
ISSN： 0369-4305

eISSN： 1881-4883
Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure -Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)-

H. Suzuki, Y. Matsumoto, H. Ota, K. Sugimura, J. Takahashi, K. Ito, Y. Fukumoto, R. Kawashima, Y. Taki, H. Shimokawa

EUROPEAN HEART JOURNAL　35　13-13　2014/09

ISSN： 0195-668X

eISSN： 1522-9645
脳局所特徴量に基づく年齢推定手法と脳MRI画像データベースを用いた性能評価(若葉研究者の集い2,サマーセミナー2014〜未来を拓くビジョン技術〜)

近藤千裕, 伊藤康一, 呉凱, 佐藤和則, 瀧靖之, 福田寛, 青木孝文

映像情報メディア学会技術報告　38　(32)　15-18　2014/08/12
Publisher: 一般社団法人映像情報メディア学会
ISSN： 1342-6893

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正常加齢に伴う脳の形態的変化を利用することで,脳MRI画像から年齢を推定することができる.従来手法では,推定に用いる特徴量が多かったり,評価に用いられているデータが数百程度しかなかったりといった問題がある.これに対して,本稿では,解剖学的意味を持つ90領域に分割した脳組織の体積を特徴量として脳年齢を推定する手法を提案する.また,大規模データベースを用いて提案手法の有効性を実証する.
慢性心不全における脳の構造・機能に関する臨床研究(B-HeFT)

鈴木秀明, 松本泰治, 古川勝敏, 瀧靖之, 荒井啓行, 下川宏明

日本老年医学会雑誌　51　(Suppl.)　147-148　2014/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
在宅医療・遠隔医療の未来東日本大震災被災地における地域医療支援の現況と今後の遠隔医療の重要性

清元秀泰, 奥田拓史, 伊藤大亮, 阿部倫明, 石井正, 鈴木洋一, 川目裕, 菅原準一, 瀧靖之, 中谷純, 井戸端永遠, 八重樫伸生, 山本雅之

医工学治療　26　(Suppl.)　76-76　2014/03
Publisher: (NPO)日本医工学治療学会
ISSN： 1344-1221
被災地在住高齢女性への園芸介入による認知機能への影響

事崎由佳, 竹内光, 関口敦, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　13th　101　2014
Development and Aging of the Human Brain Strucuture and Global Network Pattern − Image Analyses of Brain MRI Database of Healthy Japanese

Hiroshi Fukuda, Yasuyuki Taki

Journal of Tohoku Pharmaceutical University　60　13-23　2013/12
Publisher: Tohoku Pharmaceutical University
ISSN： 1345-157X
Structural abnormality of the hippocampus and depressive symptoms in a rat model of heart failure

H. Suzuki, A. Sumiyoshi, Y. Matsumoto, T. Yoshikawa, Y. Fukumoto, K. Yanai, Y. Taki, R. Kawashima, H. Shimokawa

EUROPEAN HEART JOURNAL　34　124-124　2013/08

ISSN： 0195-668X

eISSN： 1522-9645
ToMMoクリニカルフェローによる循環型地域支援の報告(第一期、第二期)

阿部倫明, 田中淳一, 高山真, 金村政輝, 奈良正之, 目時弘仁, 関口敦, 児玉栄一, 坪井明人, 瀧靖之, 菅原準一, 石井正, 清元秀泰, 八重樫伸生

日本医療・病院管理学会誌　50　(Suppl.)　272-272　2013/08
Publisher: (一社)日本医療・病院管理学会
ISSN： 1882-594X
震災後精神症状の脆弱性・獲得因子の神経基盤の解明

関口敦, 杉浦元亮, 事崎由佳, 佐久間篤, 瀧靖之, 川島隆太

トラウマティック・ストレス　11　(1)　63-67　2013/06
Publisher: 日本トラウマティック・ストレス学会 ; 2003-
ISSN： 1348-0944
東日本大震災被災地在住の軽度PTSD症状の高齢女性たちに対する園芸療法介入

事崎由佳, 竹内光, 関口敦, 荒木剛, 山本悠貴, 品田貴光, MAGISTRO Daniele, 十亀彩, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　112　2013/05/10
震災前後に認められた脳形態変化の追跡調査

関口敦, 事崎由佳, 杉浦元亮, 塙杉子, 中川誠秀, 宮内カルロス誠, 佐久間篤, 瀧靖之, 川島隆太

日本トラウマティック・ストレス学会大会プログラム・抄録集　12th　114　2013/05/10
QUASAR‐ASLにおける再現性,定量性の検討

舘脇康子, 日向野修一, 村田隆紀, 麦倉俊司, 高橋昭喜, 瀧靖之

Jpn J Radiol　31　(Supplement 1)　5　2013/02/25

ISSN： 1867-1071
Relationship between brain anatomy and an ability of non-native speech sound production in school children

HASHIZUME Hiroshi, TAKI Yasuyuki, THYREAU Benjamin, SASSA Yuko, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

日本神経化学会大会抄録集(Web)　56th　2013
健常成人における性格と局所灰白質体積減少速度との相関

瀧靖之, THYREAY Thyreau, 木之村重男, 佐藤和則, 後藤了以, 川島隆太, 福田寛

日本老年医学会雑誌　50　(5)　2013

ISSN： 0300-9173
神経性食思不振症患者の意思決定時における背外側前頭前皮質の活動亢進

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

日本摂食障害学会学術集会プログラム・講演抄録集　17th　116　2013
The relationship between developmental changes in pronunciation and brain activity during speech production in a foreign language

HASHIZUME Hiroshi, TAKI Yasuyuki, SASSA Yuko, THYREAU Benjamin, ASANO Michiko, ASANO Kohei, TAKEUCHI Hikaru, NOUCHI Rui, KOTOZAKI Yuka, JEONG Hyeonjeong, SUGIURA Motoaki, KAWASHIMA Ryuta

Technical report of IEICE. Thought and language　112　(145)　19-23　2012/07/14
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Childhood is known to be the best time in life to acquire foreign speech sounds. Therefore, it is important for foreign language education to clarify the neural process relating to foreign speech sounds. Healthy right-handed children (aged 6-18 years) participated in this study. Using functional magnetic resonance imaging, we examined their brain activation during an overt repetition and perceptual task with native and non-native syllables. The results showed that brain activation in the left inferior frontal gyrus pars opercularis, which is thought to be involved in motor control for speech production, increased with age. Additionally, accuracy of the pronunciation of non-native syllables improved with age. Those results indicate that improvement in foreign speech pronunciation might reflect maturation of the left inferior frontal gyrus.
Brain development using magnetic resonance imaging in healthy children

TAKI Yasuyuki, KAWASHIMA Ryuta

小児の脳神経　37　(3)　223-231　2012/06/30

ISSN： 0387-8023
健常成人の加齢における局所脳灰白質量の減少-383人の脳MRI解析による縦断研究-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

日本老年医学会雑誌　49　(5)　2012

ISSN： 0300-9173
健常成人の高感度C反応性蛋白と局所脳灰白質量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 福田寛, 川島隆太

日本医学放射線学会総会抄録集　71st　2012

ISSN： 0048-0428
神経性食思不振症患者の意思決定機能の脳機能画像的検討

佐藤康弘, 相澤恵美子, 関口敦, 事崎由佳, 杉浦元亮, 瀧靖之, 橋爪寛, 河内山隆紀, 川島隆太, 福土審

日本摂食障害学会学術集会プログラム・講演抄録集　16th　77　2012
383人の健常成人の縦断研究による加齢及び脳血管障害危険因子と局所脳灰白質体積減少量との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, WU Kai, 川島隆太, 福田寛

日本医学放射線学会総会抄録集　70th　2011

ISSN： 0048-0428
ヒト脳の正常発達・加齢に伴う脳形態およびネットワーク構造の変化 : 健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 瀧靖之, Wu Kai

ナノ医工学年報　5　(1)　91-100　2011
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　71　E388-E388　2011

DOI： 10.1016/j.neures.2011.07.1701 　

ISSN： 0168-0102
Sex difference in correlation between cognitive style and brain activity during visual delayed matching to sample task in children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

NEUROSCIENCE RESEARCH　71　E387-E388　2011

DOI： 10.1016/j.neures.2011.07.1700 　

ISSN： 0168-0102
認知症早期発見のためのツール開発と認知機能低下抑制介入に関する研究第2章認知機能低下抑制介入研究のプロトコール 1.有酸素運動による認知機能の低下予防に関するランダム化比較試験

辻一郎, 荒井啓行, 川島隆太, 瀧靖之, 柿崎真沙子, 遠又靖丈, 渡邉崇, 周婉てい, 丹治史也, 河村孝幸, 齋藤昌宏

認知症早期発見のためのツール開発と認知機能低下抑制介入に関する研究平成22年度総括・分担研究報告書　42-48　2011
Analysis of Normal Brain Aging using Brain MRI Database of Japanese Subjects

FUKUDA Hiroshi, TAKI Yasuyuki, Wu Kai, KAWASHIMA Ryuta

IEICE technical report.　110　(195)　61-64　2010/08/27
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Age-related change of the brain was analyzed using MRI database of the 2,500 Japanese subjects. The gray matter volume decreased with age, while white matter volume increased with age until age of 50 and then went down. Longitudinal study in 383 subjects who received the second MRI with 7 year-interval revealed that the gray matter volume decline was slower in women than that in men. Standard brain for each age and sex group was calculated using anatomical standardization technique. The brain network analysis based on graph theory using regional gray matter volume exhibited "small-world" property and modular structure. The parameters for them were different among young, middle and old group.
274人の健常小児を対象にした、年齢と灰白質体積との相関(Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis)

瀧靖之, 橋爪寛, 佐々祐子, 竹内光, Kai Wu, 野内類, 事崎由佳, 浅野孝平, 浅野路子, 福田寛, 川島隆太

神経化学　49　(2-3)　484-484　2010/08
Publisher: 日本神経化学会
ISSN： 0037-3796
人物に関する記憶の記銘時の神経活動に対する加齢の効果(Age-related differences in brain activity during successful encoding of memory for person identity information)

月浦崇, 重宗弥生, 神原利宗, 関口敦, 蓬田幸人, 中川誠秀, 秋月祐子, 瀧靖之, 川島隆太

神経化学　49　(2-3)　664-664　2010/08
Publisher: 日本神経化学会
ISSN： 0037-3796
Age-dependency in brain activation involved with imitation of unfamiliar foreign language sound: an fMRI study

HASHIZUME HIROSHI, TAKI YASUYUKI, SASSA YUKO, ASANO MICHIKO, ASANO KOHEI, TAKEUCHI HIKARU, JEONG HYEONJEONG, SUGIURA MOTOAKI, KAWASHIMA RYUTA

神経化学　49　(2/3)　664　2010/08/01

ISSN： 0037-3796
Developmental change of brain activation during sentence comprehension

YOKOYAMA Satoru, TAKI Yasuyuki, HASHIZUME Hiroshi, NOZAWA Takayuki, TAKAHASHI Kei, KAWASHIMA Ryuta

Technical report of IEICE. Thought and language　110　(163)　19-24　2010/07/29
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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Brain changes morphologically and functionally as one grows. However, it is unclear how the change of functional brain activation during sentence comprehension occurs on development. We measured functional brain images during sentence comprehension tasks of 114 juveniles from six to eighteen years old (62 girls and 52 boys) by using functional magnetic resonance imaging (fMRI). We found that the brain activation of several right hemispheric brain regions negatively correlates with age for only boys. Also, the developmental change occurs linearly.
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化 : 健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai

ナノ医工学年報　4　(1)　89-98　2010
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Relationship between gray matter volume and age in 274 healthy Japanese children applying voxel-based morphometric analysis

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Wu Kai, Rui Nouchi, Yuka Kotozaki, Kohei Asano, Michiko Asano, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E65-E66　2010

DOI： 10.1016/j.neures.2010.07.056 　

ISSN： 0168-0102
Correlation between cognitive style and brain activity in visual delayed matching task in children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Michiko Asano, Ryuta Kawashima

NEUROSCIENCE RESEARCH　68　E295-E296　2010

DOI： 10.1016/j.neures.2010.07.1312 　

ISSN： 0168-0102
Effects of aging on anterior temporal and hippocampal activations during successful retrieval of memory for person identity information Peer-reviewed

Tsukiura T, Sekiguchi A, Yomogida Y, Nakagawa S, Akitsuki Y, Taki Y, Kawashima R

The 39th Annual Meeting of Society for Neuroscience, Chicago, USA　2009/10
年齢相応の脳発達とは?

瀧靖之, 橋爪寛, 佐々祐子, 木之村重男, 後藤了以, 佐藤和則, 福田寛, 川島隆太

日本医学放射線学会総会抄録集　68th　2009

ISSN： 0048-0428
ヒト脳の正常加齢に伴う脳構造およびネットワーク構造の変化--健常日本人脳MR画像データベースを用いた画像医学的研究

福田寛, 滝靖之, Wu Kai

ナノ医工学年報　3　(1)　93-102　2009
Publisher: 東北大学グローバルCOEプログラム「新世紀世界の成長焦点に築くナノ医工学拠点」
ISSN： 1882-4692
Developmental neural networks in children performing Go/NoGo task: an fMRI study with wide age range

Hiroshi Hashizume, Yasuyuki Taki, Yuko Sassa, Michiko Asano, Kohei Asano, Hikaru Takeuchi, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S240-S240　2009

DOI： 10.1016/j.neures.2009.09.1359 　

ISSN： 0168-0102
Voxel-based morphometry of the relationships between Intelligence Quotient and brain gray matter volume in 156 healthy Japanese children

Michiko Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S226-S226　2009

DOI： 10.1016/j.neures.2009.09.1262 　

ISSN： 0168-0102
Correlation between brain activity during delayed matching task and verbal IQ in healthy children

Kohei Asano, Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Michiko Asano, Mijin Lee, Hikaru Takeuchi, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S241-S241　2009

DOI： 10.1016/j.neures.2009.09.1360 　

ISSN： 0168-0102
Relationship between gray matter volume and age in 156 healthy Japanese children: Volumetric analysis and voxel-based morphometry

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kohei Asano, Michiko Asano, Mijin Lee, Ryuta Kawashima

NEUROSCIENCE RESEARCH　65　S225-S225　2009

DOI： 10.1016/j.neures.2009.09.1261 　

ISSN： 0168-0102
Association of (18)FDG Uptake by Bone Marrow and Spleen with Hematological Parameters in Patients with and without Malignancy

K. Inoue, K. Okada, R. Goto, Y. Taki, S. Kinomura, T. Kaneta, H. Fukuda

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　35　S260-S260　2008/10

ISSN： 1619-7070
経腸IMP投与全身像による門脈体循環シャント評価

松本世津, 高浪健太郎, 金田朋洋, 丸岡伸, 高橋昭喜, 山田章吾, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

Radiation Medicine　26　(Suppl.I)　13-13　2008/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043
食道癌術後に縦隔リンパ節がFDG PETで偽陽性を呈した一例

三田村篤, 平出智道, 高浪健太郎, 金田朋洋, 丸岡伸, 山田章吾, 高橋昭喜, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　45　(1)　48-48　2008/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854
Phosphaturic mesenchymal tumorの一例

平出智道, 高浪健太郎, 金田朋洋, 丸岡伸, 山田章吾, 高橋昭喜, 三田村篤, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　45　(1)　50-50　2008/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854
FDG PETで高集積を呈した非腫瘍性卵巣病変の一例

高浪健太郎, 平出智道, 金田朋洋, 丸岡伸, 山田章吾, 高橋昭喜, 三田村篤, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　45　(1)　50-50　2008/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854
PET/CTでの吸収補正アーチファクトにおける高吸収体の「動き」の影響

金田朋洋, 高浪健太郎, 平出智道, 丸岡伸, 山田章吾, 高橋昭喜, 三田村篤, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　45　(1)　50-51　2008/02
Publisher: (一社)日本核医学会
ISSN： 0022-7854
加齢による灰白質体積の減少は男性が女性よりも早い-382人の脳MRI解析による縦断研究-

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会総会抄録集　67th　2008

ISSN： 0048-0428
経腸IMP投与全身像による門脈体循環シャント評価

松本世津, 高浪健太郎, 金田朋洋, 丸岡伸, 高橋昭喜, 山田章吾, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　44　(4)　388-388　2007/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854
加齢に伴う脳灰白質体積の経時変化-健常被験者の脳MRI解析による8年間の縦断研究第一報-

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 川島隆太, 福田寛

日本医学放射線学会学術集会抄録集　66th　2007

ISSN： 0048-0428
Body Mass Indexと全脳及び局所灰白質量との相関-1428人の脳MR画像を用いたvoxel-based morphometryによる解析-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　43rd　2007

ISSN： 0048-0428
健常高齢者における全脳及び局所灰白質量と認知力との相関 volumetry及びvoxel-based morphometryによる解析 (日本老年医学会雑誌)

瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 川島隆太, 福田寛

日本老年医学会雑誌　44　(1)　138-138　2007/01
99m Tc-MIBI SPECT/CTが有用であった副甲状腺癌再発の一例

佐藤幸子, 金田朋洋, 高浪健太郎, 高橋昭喜, 山田章吾, 丸岡伸, 瀧靖之, 岡田賢, 井上健太郎, 後藤了以, 木之村重男, 福田寛

核医学　43　(4)　351-351　2006/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854
Increase in tumor marker CA19-9 level without evident radiological findings is insufficient for justification of (18)FDG-PET examination

K. Inoue, K. Okada, Y. Taki, R. Goto, S. Kinomura, T. Kaneta, H. Fukuda

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　33　S83-S83　2006/09

ISSN： 1619-7070
Neural connectivity among regions related to language function: combined intersubject analysis by functional magnetic resonance imaging and diffusion tensor imaging tractography. Peer-reviewed

Uchida S, Miura N, Watanabe J, Kinomura S, Sato K, Taki Y, Inoue K, Goto R, Okada K, Fukuda H, Kawashima R

12th International Conference on Functional Mapping of the Human Brain　2006/06
大脳,小脳の各解剖学的構造における局所灰白質量と年齢との相関-1460人の脳MRIを用いたROI解析-

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 福田寛, 小野修一, 川島隆太

日本医学放射線学会秋季臨床大会抄録集　42nd　2006

ISSN： 0048-0428
Neural connectivity among brain areas related to language function

Shinya Uchida, Naoki Miura, John Watanabe, Shigeo Kinomura, Kazunori Sato, Yasuyuki Taki, Kentaro Inoue, Ryoi Goto, Ai Fukushima, Kaoru Horie, Shigeru Sato, Katsuki Nakamura, Hiroshi Fukuda, Ryuta Kawashima

NEUROSCIENCE RESEARCH　55　S263-S263　2006

ISSN： 0168-0102
Correlation between semantic memory and regional gray matter volume of anterior aspect of right temporal lobe in normal elderly subjects. A voxel-based morphometry

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Shinya Uchida, Ryoi Goto, Kentaro Inoue, Ichiro Tsuji, Hiroyuki Arai, Ryuta Kawashima, Hiroshi Fukuda

NEUROSCIENCE RESEARCH　55　S103-S103　2006

ISSN： 0168-0102
Association between depressive symptoms and cerebrovascular lesions on MRI in community-dwelling elderly individuals

Toru Seki, Shuichi Awata, Yayoi Koizumi, Shigeo Kinomura, Yasuyuki Taki, Atsushi Hozawa, Kaori Ohmori, Shinichi Kuriyama, Hiroshi Fukuda, Ichiro Tsuji

Japanese Journal of Geriatrics　43　(1)　102-107　2006
Publisher: Japan Geriatrics Society
DOI： 10.3143/geriatrics.43.102 　

ISSN： 0300-9173
Association between depressive symptoms and cerebrovascular lesions on MRI in community-dwelling elderly individuals

Toru Seki, Shuichi Awata, Yayoi Koizumi, Shigeo Kinomura, Yasuyuki Taki, Atsushi Hozawa, Kaori Ohmori, Shinichi Kuriyama, Hiroshi Fukuda, Ichiro Tsuji

Japanese Journal of Geriatrics　43　(1)　102-107　2006
Publisher: Japan Geriatrics Society
DOI： 10.3143/geriatrics.43.102 　

ISSN： 0300-9173
脳血流SPECT画像を用いたアルツハイマー病患者と正常者の弁別読影精度を数値解析で予測する試み (核医学)

志田原美保, 井上健太郎, 瀧靖之, 岡田賢, 後藤了以, 木之村重男, 福田寛, 丸山将浩, 荒井啓行

核医学　42　(3)　313-313　2005/09
診療 "年齢相応の脳"とは?(第1報)

瀧靖之, 木之村重男, 後藤了以

臨床放射線　50　(8)　983-990　2005/08
Publisher: 金原出版
ISSN： 0009-9252
「年齢相応の脳」とは?多施設での比較のために

瀧靖之, 木之村重男, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 福田寛, 川島隆太, 伊藤浩

日本医学放射線学会秋季臨床大会抄録集　41st　2005

ISSN： 0048-0428
地域在住の高齢者における頭部MRI上の脳血管性病変と抑うつ症状との関連横断的研究

関徹, 粟田主一, 小泉弥生, 木之村重男, 後藤了以, 井上健太郎, 瀧靖之, 寶澤篤, 大森芳, 栗山進一, 松岡洋夫, 福田寛, 辻一郎

老年精神医学雑誌　15　(5)　595-596　2004/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
肺非結核性抗酸菌症のCT画像:特に肺結核との鑑別に関して

小野修一, 山田隆之, 壺井匡浩, 瀧靖之, 窪田和雄, 石橋忠司, 高橋昭喜, 福田寛

日本医学放射線学会雑誌　63　(2)　S65-S65　2003/02
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
非結核性抗酸菌症の画像診断

小野修一, 中川学, 瀧靖之, 窪田和雄, 福田寛, 山田隆之, 壺井匡浩, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　62　(12)　710-710　2002/10
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
上肺野優位の特発性間質性肺炎Pulmonary Apical Fibrocystic Diseaseの画像診断

小野修一, 山田隆之, 壺井匡浩, 瀧靖之, 窪田和雄, 石橋忠司, 高橋昭喜, 福田寛

日本医学放射線学会雑誌　62　(3)　S132-S132　2002/03
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
脳血流SPECTカウントは脳灰白質密度を反映するか?

木之村重男, 後藤了以, 井上健太郎, 中川学, 瀧靖之, 佐藤和則, 川島隆太, 福田寛

核医学　39　(3)　2002

ISSN： 0022-7854
上肺野優位の特発性間質性肺炎の画像診断

小野修一, 瀧靖之, 窪田和雄, 福田寛, 山田隆之, 壷井匡浩, 石橋忠司, 高橋昭喜

日本医学放射線学会雑誌　62　(1)　36-36　2002/01
Publisher: (公社)日本医学放射線学会
ISSN： 0048-0428
Elevation of systolic blood pressure accelerates shrinkage of the gray matter.

Y Taki, R Kawasima, R Goto, K Sato, S Ono, S Kinomura, M Nakagawa, M Sugiura, J Watanabe, H Fukuda

NEUROIMAGE　13　(6)　S1009-S1009　2001/06

ISSN： 1053-8119
Normal aging and sexual dimorphism of Japanese brain

R Goto, R Kawashima, A Zijdenbos, P Neelin, J Lerch, K Sato, S Ono, M Nakagawa, Y Taki, M Sugiura, J Watanabe, H Fukuda, AC Evans

NEUROIMAGE　13　(6)　S794-S794　2001/06

ISSN： 1053-8119

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Presentations 6

大脳、小脳の各解剖学的構造における局所灰白質量と年齢との相関

瀧靖之, 木之村重男, 佐藤和則, 後藤了以, 井上健太郎, 岡田賢, 小野修一, 川島隆太, 福田寛

第42回日本医学放射線学会秋季臨床大会　2006/10/26
健常高齢者における全脳及び局所灰白質量と認知力との相関：

瀧靖之, 木之村重男, 佐藤和則, 内田信也, 後藤了以, 井上健太郎, 辻一郎, 荒井啓行, 川島隆太, 福田寛

第17回日本老年医学会東北地方会　2006/09/01
Correlation between semantic memory and regional gray matter volume of anterior aspect of right temporal lobe in normal elderly subjects. A voxel-based morphometry.

Yasuyuki Taki, Shigeo Kinomura, Kazunori Sato, Shinya Uchida, Ryoi Goto, Kentaro Inoue, Ichiro Tsuji, Hiroyuki Arai, Ryuta Kawashima, Hiroshi Fukuda

第29回日本神経科学大会　2006/07/19
Gray matter ratio（年齢相応の脳萎縮の尺度）と年齢との相関は、世代、性で差が見られる

瀧靖之, 木之村重男, 福田寛

第15回日本脳ドック学会総会　2006/06/30
Highly proficient group of acquired second language shows larger global and regional gray matter volumes than poorly proficient group International-presentation

Yasuyuki Taki, Hideyuki Okamoto, Yuko Sassa, Naho Ikuta, Hyeonjeong Jeong, Kaoru Horie, Shigeru Sato, Shigeo Kinomura, Hiroshi Fukuda, Ryuta Kawashima

12th Annual Meeting of Human Brain Mapping　2006/06/11
加齢に伴う局所灰白質の萎縮は、世代及び性で相違が見られる

瀧靖之, 木之村重男, 後藤了以, 井上健太郎, 岡田賢, 小野修一, 川島隆太, 福田寛

第65回日本医学放射線学会学術集会　2006/04/07

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Research Projects 23

認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発

瀧靖之, 古本祥三, 領家梨恵, 米田哲也, 岡村信行, 舘脇康子, 関根弘樹, 中瀬泰然

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2023/04/01 - 2026/03/31
認知症におけるオートファジー障害の病態解明とPADREによる超早期画像診断法の開発

瀧靖之, 古本祥三, 領家梨恵, 米田哲也, 岡村信行, 舘脇康子, 関根弘樹, 中瀬泰然

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2023/04/01 - 2026/03/31
大規模縦断コホートデータを用いた義歯の認知症予防効果のエビデンスの探索

坪井明人, 瀧靖之, 大井孝, 山口哲史

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31
脳MRI定量指標の臨床応用へ：AIを用いた画像駆動型緑内障診断ソフトウェアの開発

舘脇康子, 瀧靖之, 中澤徹, Thyreau Benjamin, 武藤達士, 面高宗子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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緑内障は本邦において推計400万人が罹患する老年病であり、網膜神経節細胞脱落部位に応じた進行性の視野障害を特徴とする。緑内障では網膜だけではなく中枢視路である視神経から大脳視覚野にまで体系的に変性が及び、MRI技術を用いてこれらの変化を詳細に可視化・定量化する試みが行われているが、未だ臨床応用には至っていない。本研究は脳MRI画像から得られる視野障害の程度を反映する定量指標を、客観的な新たな視機能評価法として臨床応用することを目指す。本研究は既存の知見をもとに脳MRI情報から視機能を予測するモデル構築を行い、さらにAIを活用して高精度の診断性能を持つソフトウェア開発を目指したものである。当初、R3年度は100名のテストデータの収集を予定していたが、コロナ感染の収束が見通せず、データ収集は断念した。代わりに、当該年度では既存の緑内障縦断MRIデータベースの約280症例のデータを用いて、画像解析プログラム開発を進めた。まずは、眼科データの充実化を行った。これまでのデータベースに含まれていたMDやOCTによるRNFLTの値だけではなく、網膜に残存する網膜神経節細胞数の推定値であるwRGC（weighted retinal ganglion cell count）の算出を行い、緑内障進行度を示すパラメータとして追加した。wRGCは緑内障の早期から後期にかけての視機能との追従性が良好で、既存のパラメータと比較して緑内障の進行度をより正確にとらえることができると考えられる。次に、画像解析に先立ち、緑内障縦断コホートの解剖学的3D-T1強調画像を対象としてFreesurferにより詳細な灰白質構造の抽出を行い、percellationとsegmentation技術を用いて全脳の解剖学的構造を関心領域とした、各構造の体積と皮質厚データを取得し、視野を推定する数理モデル作成およびAIシステム構築のための準備を行った。
Prediction of human facial morphology based on genome polymorphisms

Imanishi Tadashi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tokai University

2019/04/01 - 2022/03/31

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Since the human facial morphology is a trait with a very high heritability, it is in principle possible to predict the facial morphology using information on genomic polymorphisms. Our research team has been working on the development of software "Genome Montage" for predicting human facial morphology based on genomic polymorphisms. Using 3-dimensional facial morphological data of the Japanese subjects, we succeeded in developing basic software of Genome Montage, by predicting principal component scores of the facial morphology from the genomic polymorphism data using genome-wide polygenic scores. In the future, we aim to improve the accuracy of predicted faces by increasing the number of subjects to about several thousands and by improving the software.
Development of a tool to predict cognitive decline using metabolomics analysis

Hozawa Atsushi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2022/03/31

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We observed that several metabolomics were associated with change in congnitive function. After excluding metabolomics which highly correlated with other metabolomics, we selected 6 metabolme markers to establish metabolome score. Using the score, higher metabolome score showed lower decline of cognitive function. Especially, participnts with metabolome score 0 showed marked decline in cognitive function The prediction model with metabome score showed larger area under the ROC curve(0.772) compared with the model without. Prediction model with metabolome score may have better potential to predict cognitive dysfucnction. Validation study using ToMMo is now analyzing.
Effects of Diet and Nutrients on Cognitive Indices and Brain Morphology: An Examination Using Omics Analysis

Kogure Mana

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2017/04/01 - 2021/03/31

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We examined the relationship between diet/food intake and brain morphology. The results showed that in the without energy intake adjusted, mushroom intake was significantly positively associated with gray matter capacity independent of confounding factors. In terms of dietary pattern, the group with the highest “Western food pattern” score had significantly higher gray matter capacity and hippocampal capacity. Furthermore, the results of omics analysis were added to the above analysis model, which suggested that amino acids may modify these relationships. This study examined the results of omics analysis using only representative amino acid results, we will examine the results in detail through collaborative research to identify metabolites that may contribute to brain well-activity in the future.
Modeling of individuality in human cognition and its neurological basis

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Chiba University

2016/06/30 - 2021/03/31
Brain development aging using large brain MRI database

Taki Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2020/03/31

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We have built a brain magnetic resonance imaging (MRI) database to reveal how brain ages. We have also collected several cognitive functions, lifestyle such as eating and sleeping habits, and genetic data. Using the database, we have revealed normal brain development and aging, and also have revealed what factors affect brain development and aging. For example, several factors such as hypertension, alcohol drinking, smoking, and obese are risk of dementia. In addition, several disorders such as glaucoma and osteoporosis affects brain function. These findings help understanding the mechanism of brain aging.
Development of genome montage technology for predicting facial morphology

IMANISHI Tadashi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tokai University

2016/04/01 - 2019/03/31

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Because most identical twins have similar looks, there seems to be strong genetic factors contributing to the human facial morphology. In this study, we aimed to reveal the genetic factors that determine the personal variation of faces by collecting and analyzing morphological and genetic data. We held events for measuring facial morphology by a 3D scanner and collecting DNA samples from Japanese volunteers including twins and siblings. Using the data for 186 individuals, we predicted heritability of various parts of faces. We also examined genetic polymorphisms for 380 volunteers collected by IDAC of Tohoku University, and are carrying out the genome-wide association study of head MRI data. In this way, we succeeded in developing infrastructure for the study of genome montage technology.
Development of systemic management after subarachnoid hemorrhage focusing on cerebral microcirculation

Mutoh Tatsushi, TAKI yasuyuki, TSUBONE hirokazu, ISHIKAWA tatsuya, NAKAMURA kazuhiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2019/03/31

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Early brain injury and related cardiac consequences play a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). We aimed to evaluate the feasibility of multimodality imaging using MRI, two-photon laser scanning microscopy, high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid hemorrhage (SAH). Real-time measurements of cerebral blood flow, brain tissue oxygen saturation, and cardiac output (CO) were analyzed. Our in vivo experiments further demonstrated the potential role of the transcription factor STAT3 in the rapamycin-mediated neuroprotection in a mouse model of SAH. We propose that rapamycin is a novel pharmacological strategy to target STAT3 activation for the treatment of post-SAH early brain injury.
RNF213 gene related intracranial findings and risk evaluation for moyamoya disease

Kure Shigeo, TAKI YASUYUKI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Tohoku Medical Megabank has started screening program of brain MRI findings in its resident cohort.In this study we compered brain MRI/MRA findings of two participant groups that have the c.14576G>A-mutation or not, a Moyamoya disease related mutation in RNF213. Several findings specific to the mutation-positive group were identified. Volumes of various brain regions were measured, which were subject to statistical analysis for significant difference between the two groups.No metabolite has been identified to date, which plasma level differs significantly between the mutation-positive and negative groups.
可塑性イメージングと脳計測技術を用いた自閉症の巨視的ネットワーク機能障害の解明

瀧靖之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 新学術領域研究(研究領域提案型)

Institution: 東北大学

2015/04/01 - 2017/03/31

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ラットに学習を行わせると、学習の習熟に伴い皮質の神経回路再編が起こり、LTP/LTD可塑性変化とともに回路の組織学的形態変化が起こることが知られている。核磁気共鳴法(MRI)の撮像法の一つである水拡散強調画像法は、生体環境内の自由水分子のブラウン運動を計測することで、組織内環境の変化を推定できる。我々は、学習で起こる皮質神経回路の形態変化をMRIで質神経回路の可塑性変化を観察できるか検討した。我々は、ラットに短期間もしくは長期間のバーンズ空間迷路学習を行わせ、学習の初期と後期で水拡散能の変化を観察した。コントロールとして、その期間中は学習をしない群を別に設けた。短期間学習は1日２試行×連続2日間（計4試行）、長期間学習は、1日2試行×連続6日間(計12試行)で行った。生体ラット脳のMRI撮像を学習の前後に行い、学習前に対して学習後の皮質水拡散能の変化を算出した。短期2日間の学習では、1試行目と最終試行(4試行目)を比較すると成績の改善が認められたものの、1週間後には成績が悪化した。長期6日間の学習では、1試行目と最終試行(12試行目)を比較すると成績の改善が認められ、短期2日間学習群よりも成績の改善度が大きかった。1週間後でもその改善が減衰せず保たれていた。短期学習群、長期学習群ともに、学習前に比べて学習後で海馬の水拡散能に変化が認められた。非学習群ではその期間中に水拡散能の変化が認められなかった。短期学習群では水拡散能が低下した。長期学習群では水拡散能が上昇した。学習の習熟過程で、数日の時間窓で樹状突起スパインが増加しその後除去が起こることが知られている。我々が観察した水拡散能の低下その後の上昇が、その組織学的変化と関係があるのか今後検討する予定である。
ＰＴＳＤ患者の震災ストレス反応、生活習慣と脳形態、認知力との相関

瀧靖之, LANDRE LIONEL, LANDRE Lionel

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特別研究員奨励費

Institution: 東北大学

2014/04/25 - 2017/03/31

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東北大学東北メディカル・メガバンク機構の脳画像データベースを用いて、今年度は約2000人の脳画像データ、認知力、ストレスレベル、生活習慣等のデータ収集を行った。これらのデータを用いて、心的外傷後ストレス障害（PTSD）等のストレスレベルが脳形態、認知力にどの程度影響するかを解析した。具体的には、重度の震災被害によるストレスにより、どの程度海馬を主体とする脳萎縮に影響を与えるか、またそれが年齢、性別、ストレスレベルによりどのように萎縮の程度が変わるかを解析した。その結果、震災時、沿岸部に居住しており、ストレスレベルの高い、かつ男性ほど、海馬の体積が萎縮していることが明らかになった。これらの結果は、ストレスレベルが高い程、海馬体積が萎縮するという、これまでの研究結果に一致した結果であるが、それだけでは無く、そこには性差がある可能性が示唆された。特に男性においてストレスと海馬体積に有意な相関が見られたことに関して、このような性差が何故見られたかは明らかでは無いが、可能性としては、男性の方が社会性が低いために、地域のコミュニティを築きにくいこと、それがストレス軽減につながらないことにより、海馬体積がより萎縮した可能性が考えられる。併せて、コミュニティを築きにくいことが外出頻度を減らし、それが運動による海馬の神経新生を抑えた可能性も考えられる。大災害後の認知症や鬱のリスクを評価する際に、性差は大変重要である可能性が示唆された。これらの結果を学術誌などに発表する予定である。
Investigation of the neural mechanisms underlying autism based on the hypothesis of functional imbalance between frontal and parietal region

Wakusawa Keisuke, TAKI YASUYUKI, TSUCHIYA KENJI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

2013/04/01 - 2017/03/31

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Autism spectrum disorder (ASD) is characterized by restricted interests and impaired social communication. One of the most specific cognitive characteristics of ASD is imbalanced cognitive profile shown in psychological test or in real life. However, there have been no test or neuro-imaging approaches to evaluate the quantity of this imbalance. Our purpose was to develop such approaches. We examined the performances of ASD individuals of the tasks related to adaptation to novel and typical daily situations (these tasks were developed by our previous study), and detected ASD-specific imbalanced pattern. We also found that the imbalance of cortical activities linked to these tasks were correlated with the severity of ASD. furthermore, we detected another autistic imbalanced findings in brain; imbalanced proportion of the density of neural fiber between the cortical regions related to language production and those related to comprehension of others' mind.
自閉症スペクトラム障害における共感性の脳内基盤

瀧靖之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 新学術領域研究(研究領域提案型)

Institution: 東北大学

2014/04/01 - 2016/03/31

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自閉症スペクトラム障害成人、及び同小児から、脳MRI、empathizing quotient（EQ）の質問紙を用いた共感性の程度、食事、運動、睡眠などの生活習慣、WAIS/WISCによるIQ、だ液収集による遺伝子等のデータを収集した。脳MRI画像は、voxel-based morphometry (VBM)の手法を用いて局所脳解析を行うためのデータを作した。遺伝子は、BDNF、ApoE、COMTとした。得られたデータに対し、一般線型モデルを用いて、局所脳体積や血流量、白質微小構造と共感性の程度を明らかにした。EQのスコアと有意な相関を呈する脳領域を明らかにすることで、健常から疾患群まで体系的に、共感性の脳内基盤を明らかにした平成27年度に自閉症スペクトラム障害児における共感性の脳内基盤に関する研究を遂行した。具体的には250名の5～18歳の小児の脳MRI画像を用いて、共感性と相関する脳領域を明らかにした。その際、脳MRI及び種々の生活習慣データ、遺伝子データ、及び共感性のデータを収集し、共感性の脳内基盤、及び生活習慣や遺伝要因との相関を、脳形態、脳血流、脳白質微小構造の観点から明らかにした。その結果、システム化指数から共感性指数を引いた、Dscoreは、女児においてシルビウス裂周囲の局所灰白質体積と相関があることを明らかにした。更に、親子関係において、子どもを褒めることが脳形態にも影響を与えることを明らかにした。具体的には、親の褒める頻度と、子の島背側の局所灰白質体積に有意な正相関が見られ、この部位は痛みや共感にも関係していると考えられることから、親が子どもを褒めることは、子どもの共感性を高めるのに重要であることを示した。本結果は、英文誌PLoS ONEに受理され、現在印刷中である。
Effect of cognitive rehabilitation for early schizophrenia patients on cognitive function and brain structures

HIROO Matsuoka, MATSUMOTO Kazunori, TAKI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Cognitive impairment is one of the core symptoms of schizophrenia that significantly influences patients’ social function. Cognitive remediation, of which a main component is repetitive cognitive training, is a promising approach for this impairment. In this study, we used brain training games as a cognitive training program. In addition to measuring the change in cognitive performance from pre- to post-intervention, we investigated the influence of cognitive training on gray matter structures. An 8-week intervention revealed that cognitive training using brain training games significantly improved patients’ processing speed and executive function compared to visuospatial puzzle games. In addition, the improved cognitive performance was accompanied by regional gray matter volume changes. These findings suggest that cognitive training not only influences the performance on cognitive measures, but also patients’ neural structures.
Relationship among brain structure, genetic factor, lifestyle, and cognitive functions

TAKI Yasuyuki, TOMITA Hiroaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2011/04/01 - 2015/03/31

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We have collected brain magnetic resonance imaging, cognitive function, gene, and lifestyle data from healthy subjects. As a result, We have shown that the rate of brain volume decline with aging, that relationship between brain volume decline rate and lifestyle such as sleeping habit, and that relationship between brain volume declune rate and genetic factor. These results are useful for early diagnosis of dementia as well as maintaining healthy brain throughout life.
Comprehensive analysis of human brain network structure based on graph theory using brain MRI

FUKUDA HIROSHI, TAKI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

2011/04/01 - 2015/03/31

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The human brain exhibits a complex network and makes information transmission with high efficiency. We performed network analysis based on graph theory using a large scale brain MRI database of healthy Japanese. The results indicated that subjects from children to older age exhibited a “small-world” property in that they are characterized by highly connected hubs and modularity. Structural brain networks in three age groups (young, middle, old) changed developed into a more distributed organization from young to middle age and then altered greatly, shifting into a more localized organization in old age. The modular organization of brain network was similar between the young and middle age groups, but quite different from the older groups. In particular, the old group showed a notable decrease in the connector ratio and the inter-module connection. Our findings provide quantitative insights into topological principles of brain networks and changes related to normal aging.
Relationship between sleep duration and brain volume / cognitive function in elderly subjects.

KAKIZAKI Masako, TSUJI Ichiro, TOMATA Yasutake, SUGAWARA Yumi, WATANABE Takashi, SUGIYAMA Kenmyo, KOGURE Mana, CHOU Wan-ting, HONKURA Kenji, KAIHO Yu, MATSUO Kaneyuki, SONE Toshimasa, TAKAHASHI Hideko, BENJAMIN Thyreau, TAKI Yasuyuki, AIDA Jun

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2012/04/01 - 2014/03/31

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Recent epidemiological studies have reported physical activity or sleep duration were associated with cognitive decline and brain's natural capacity for plasticity. However, it is not clear the effects of sleep duration on the brain areas in the elderly. The purpose of this study is to evaluate the relationships between self-reported habitual sleep duration and brain's natural capacity / cognitive function among elderly subjects. We analyzed cross-sectional data from a community-based Comprehensive Geriatric Assessment (CGA) conducted among elderly Japanese subjects living in Tsurugaya district. The correlation between self-reported habitual sleep duration and brain gray matter volumes of all region including the hippocampus was not significant (p<0.05). The significant relationship was not found for the cognitive function score
Post-traumatic stress reduction and improvement of mental and physical function by horticultural therapy intervention

KOTOZAKI Yuka, KAWASHIMA Ryuta, TAKI Yasuyuki, TAKEUCHI Hikaru, SEKIGUCHI Atsushi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2012/04/01 - 2014/03/31

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The purpose of this study was to reveal reduction of post-traumatic stress disorder (PTSD) and improvement of mental and physical function of residents who living the disaster area by horticultural therapy intervention. We carried out two intervention study; (a) the intervention of 54 women who lining the disaster area and (b) the intervention of 39 elderly women who lining the disaster area. As a result, in the intervention study of 54 women, the intervention group was increased the gray matter volume of the left subgenual anterior cingulate cortex and inferior frontal gyrus, Additionally, the intervention group was significantly improved CAPS score, PANAS PA score, PTGI-J score, and stress markers (cortisol and amylase). In the intervention study of 39 elderly women, the intervention group was improved depression symptom, QOL, and stress marker (cortisol).
Correlation between age and gray/white matter volume in healthy children using brain magnetic resonance imaging

TAKI Yasuyuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2008 - 2010

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We analyzed the correlation among gray matter volume, cerebral blood flow, age, and lifestyle in 300 healthy children using brain magnetic resonance imaging. As a result, we have revealed that the cerebral blood flow of the resting state shows the increase followed by the decrease trajectory, and that the age at the peak of the cerebral blood flow is different among the brain regions. In addition, we have revealed that the kind of staple in the breakfast affect the gray matter volume and cognitive function in healthy children. These results may contribute to clarifying the normal brain development in healthy children.
脳萎縮の客観的診断尺度であるGMRの年齢、脳血管障害危険因子との相関の縦断的研究

瀧靖之

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 若手研究(B)

Institution: 東北大学

2007 - 2008

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昨年度に引き続き、本研究の被験者のMRI撮像及び臨床データ収集を行った。本年度5月にて被験者443人の撮像及び臨床データ収集を全て終了した。更に、得られた脳画像に対し、頭蓋内体積を灰白質体積で割ることで各個人のgray matter ratio(GMR)を得た。次に前回のプロジェクトと今回の得られたデータから、全被験者のGMRの一年あたりの変化率(Annual Percent Change of GMR:APCGMR)を算出した。その結果、男性は女性よりもAPCGMRが有意に大きく(p<0.001)、また女性では50歳未満よりも50歳以降の方が、有意にAPCGMRが大きい(p=0.008)ことが明らかになった。更に、肥満の指標であるBody mass indexはAPCGMRの有意な説明変数であることも明らかになった。以上の結果から、健常人における脳灰白質体積減少は性差、世代差があることが明らかになり、脳ドックなどの臨床現場において年齢相応の脳体積減少率を用いる際の基礎データになることが期待される。更に、近年の報告からごく軽度のアルツハイマー病群でも、灰白質体積減少率は年齢を合わせた健常群よりも高いことが明らかになっているので、これらの健常群の灰白質体積減少率のデータは脳萎縮を伴う疾患の鑑別や早期発見に非常に有用なデータと考えられる。加えて、50歳前の女性軍での灰白質体積減少率は高齢群や男性群と比較して有意に低いという性差、世代差の結果から、これまで動物実験にて示唆されているエストロゲンの脳細胞保護作用に関して、これを裏打ちしている結果の可能性が考えられ、健常な加齢による灰白質体積減少のメカニズムを推測する上での基礎データの一つになることが期待される。更に、本結果から肥満による灰白質体積減少を縦断研究にて直接示したので、脳灰白質体積の観点から肥満の予防の重要性を明らかにした。

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