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Masatsugu Orui

Section

International Research Institute of Disaster Science

Job title

Associate Professor

Degree

M.D., Ph.D (Yamagata University)

researchmap

https://researchmap.jp/7000018869

J-GLOBAL ID

201701003836811160

Research History 8

2024/08 - Present

International Research Institute of Disaster Science, Tohoku Medical Megabank Organization, Tohoku University　Associate Professor
2023/04 - 2024/07

Tohoku University　Tohoku Medical Megabank Organization Department of Preventive Medicine and Epidemiology　Lecture
2019/04 - 2023/03

Senai City Mental Health and Welfare Center
2016/04 - 2019/03

Fukushima Medical University　School of Medicine
2013/04/01 - 2016/03/31

仙台市健康福祉局精神保健福祉総合センター
2012/04/01 - 2013/03/31

山形県村山保健所（兼）山形県健康福祉部
2009/04/01 - 2012/03/31

山形県立鶴岡病院
2004/04/01 - 2009/03/31

山形県健康福祉部

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Education 2

Yamagata University　Graduate School, Division of Medical Sciences　Public Health

2003/04/01 - 2008/03/31
Yamagata University　Faculty of Medicine　School of Medicine

1995/04/01 - 2001/03/31

Committee Memberships 8

日本公衆衛生学会災害・緊急時公衆衛生活動委員会　委員

2025/12 - Present
日本公衆衛生学会広報/ e-ラーニング委員会　委員

2021/11 - Present
仙台市宮城野区地域ケア会議・障害者自立支援協議会　委員

2021/10 - Present
日本疫学会　代議員

2021/06 - Present
日本公衆衛生学会日本公衆衛生雑誌　編集委員

2021/01 - Present
日本社会精神医学会日本社会精神医学会雑誌　査読委員

2020/09 - Present
日本公衆衛生学会　代議員

2021/07 - 2025/06
日本公衆衛生学会日本公衆衛生雑誌　査読委員

2018/04 - 2021/03

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Professional Memberships 5

日本自殺予防学会
日本精神神経学会
日本疫学会
日本公衆衛生学会
日本社会精神医学会

Research Interests 4

Epidemiology
Suicide Prevention
Health Policy
Mental Health

Research Areas 3

Life sciences / Hygiene and public health (non-laboratory) /
Life sciences / Hygiene and public health (non-laboratory) /
Life sciences / Hygiene and public health (non-laboratory) / Public Hygiene Studies/Health Science

Awards 4

日本公衆衛生学会日本公衆衛生雑誌編集委員会ベストレビュワー賞

2020/10/20　日本公衆衛生学会
日本公衆衛生学会奨励賞

2019/10/24　日本公衆衛生学会
第76回日本公衆衛生学会優秀ポスター賞

2017/11/01　第76回日本公衆衛生学会学術総会　東日本大震災および原子力発電所事故後の勤労者の精神的健康を保持する要因の検討
第33回日本社会精神医学会優秀発表賞

2014/03/21　日本社会精神医学会

Papers 120

Early social gaze fixation and later inattention and hyperactivity–impulsivity symptoms in children: A longitudinal population‐based cohort study Peer-reviewed

Masatsugu Orui, Mami Ishikuro, Taku Obara, Keiko Murakami, Aoi Noda, Genki Shinoda, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Tomoko Nishimura, Keiko Tanaka, Yoshihiro Miyake, Atsushi Hozawa, Kenji J. Tsuchiya, Shinichi Kuriyama

Psychiatry and Clinical Neurosciences Reports　2026/09

DOI： 10.1002/pcn5.70380 　
Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study Peer-reviewed

Ami Uematsu, Hisashi Ohseto, Masatsugu Orui, Zheng Xian, Yuta Takahashi, Geng Chen, Keiko Murakami, Mami Ishikuro, Aoi Noda, Genki Shinoda, Taku Obara, Tomoki Nakaya, Shinichi Kuriyama

Pediatric Allergy and Immunology　2026/04

DOI： 10.1111/pai.70338 　
Risk of Major Congenital Malformations Associated With the First-Trimester Exposure to Antipsychotics: A Large Claims Database Study. International-journal Peer-reviewed

Ryo Obara, Takamasa Sakai, Tomofumi Ishikawa, Kei Morishita, Motohiko Adomi, Azusa Hara, Saya Kikuchi, Natsuko Kobayashi, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Nariyasu Mano, Shinichi Kuriyama, Taku Obara

Pharmacology research & perspectives　14　(2)　e70231　2026/04

DOI： 10.1002/prp2.70231 　

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This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to antipsychotics, using a large claims database in Japan. This retrospective cohort study was based on data from a large claims database in Japan. We used a large claims database from 2010 to 2019. Dates of pregnancy onset and delivery were estimated using the developed algorithms. Overall MCMs were defined according to the International Classification of Diseases, 10th revision codes. To address confounding by indication, the risk of MCM in relation to first-trimester antipsychotic use was evaluated among pregnant women with psychiatric disorders diagnosed before the end of the first-trimester. We compared the prevalence of MCMs among infants born to pregnant women with or without first-trimester exposure to antipsychotics and estimated the weighted odds ratios (wORs) using propensity-score overlap weights. The prevalence of psychiatric diagnoses before the end of the first-trimester was 6291 women among the 91 390 who delivered between 2010 and 2019. Among the 6291 diagnosed with psychiatric disorders, 317 were exposed to any antipsychotics during the first-trimester of pregnancy. The prevalence of overall MCMs among live births was 411 (6.9%) among women unexposed to any antipsychotics and 24 (7.6%) among those exposed. The first-trimester exposure to any antipsychotics was not significantly associated with overall MCMs when wORs were calculated using propensity-score overlap weights (wOR 1.144, 95% confidence intervals 0.727-1.799). Exposure to any antipsychotics during the first-trimester of pregnancy was not associated with an increased risk of overall MCMs in infants.
Association between exposure to Kampo medicines containing Ephedra and major congenital malformations: A Japanese administrative claims database study Peer-reviewed

Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

Traditional & Kampo Medicine　13　(1)　2026/03/25
Publisher: Wiley
DOI： 10.1002/tkm2.70049 　

ISSN： 2053-4515

eISSN： 2053-4515

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ABSTRACT Aim Traditional Japanese (Kampo) medicines containing ephedra (KE) are prescribed for cold during pregnancy; however, detailed safety information on their use in pregnant women is lacking. This study aimed to clarify the association between prescription of KE during the first trimester of pregnancy and major congenital malformations (MCMs) in newborns. Methods Data from a large Japanese administrative claims database were analyzed: we included records of pregnant women who continued to be covered in the same health insurance society from 3 months before pregnancy until delivery, who gave birth between 2010 and 2019; the selected records included data relating to the infants until first year from birth. Pregnant women who were prescribed acetaminophen, commonly used to treat colds, in the first trimester of pregnancy and their infants were treated as the controls in our analysis. Results Of 75,398 infants, 4607 (6.1%) were diagnosed with MCMs within the first year of birth. Among the 7820 infants whose mothers were prescribed acetaminophen, 497 (6.4%) had MCMs. Of the 4772 infants were born to women prescribed KE, among whom 327 (6.9%) had MCMs. adjusting for covariates with propensity score overlap weights identified no significant difference in MCM risk between the two types of prescriptions (overlap‐weighted odds ratio 1.077, 95% confidence interval 0.932−1.245). Conclusion The results of this study indicated that the risk of MCMs did not differ between women prescribed KE and those prescribed acetaminophen in the first trimester of pregnancy.
Routine Life-Course Health Records in Infancy Predict Being Overweight in Childhood and Adolescence: The TMM BirThree Cohort Study Peer-reviewed

Genki Shinoda, Mami Ishikuro, Taeka Matsubara, Aoi Noda, Keiko Murakami, Masatsugu Orui, Hirohito Metoki, Masahiro Kikuya, Atsushi Hozawa, Shinichi Kuriyama, Kenji Nakamura, Taku Obara

Children　2026/02/26

DOI： 10.3390/children13030334 　
Association of subjective and objective physical activity with home hypertension. International-journal Peer-reviewed

Saki Hayashi, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Masato Takase, Sayuri Tokioka, Masatsugu Orui, Eiichi N Kodama, Yohei Hamanaka, Mami Ishikuro, Taku Obara, Satoshi Nagaie, Tomohiro Nakamura, Soichi Ogishima, Sho Nagayoshi, Mitsuo Kuwabara, Toshiyuki Iwaoka, Nobuo Fuse, Yoko Izumi, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2026/02/24

DOI： 10.1038/s41440-026-02587-8 　

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Prevention of hypertension (HT), a risk factor for cardiovascular diseases, and blood pressure (BP) control are important. For the prevention and management of high BP, increased physical activity (PA) is recommended as a lifestyle intervention. Although various PA assessment methods exist, their associations with clinical BP have been inconsistent. This study aimed to compare self-reported and accelerometer-measured PA in relation to home HT prevalence based on home BP, which has better reproducibility than office BP. We conducted this cross-sectional study of 5895 participants (mean age: 57.5 years, 70.4% women) in the Tohoku Medical Megabank Project Cohort Study. Total PA was assessed using two methods: self-reported activities (leisure, occupational/household) and accelerometer-measured values. Home HT was defined as morning home BP ≥ 135/85 mmHg or under HT treatment. Modified Poisson regression analysis showed no statistically significant association between self-reported total PA and the prevalence of home HT. In contrast, higher levels of accelerometer-measured total PA were associated with lower prevalence of home HT (P for trend <0.05). Regarding other accelerometer-measured components, higher light PA and more steps were also significantly associated with lower prevalence of home HT. These associations were largely mediated by body mass index. In conclusion, accelerometer-measured PA, unlike self-reported PA, was associated with home HT, suggesting that PA assessed by accelerometers is useful for understanding the relationship between PA and HT, preventing HT, and managing high BP.
Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population. International-journal Peer-reviewed

Hisashi Ohseto, Kosuke Inoue, Ippei Takahashi, Taku Obara, Akira Narita, Mami Ishikuro, Masatsugu Orui, Keiko Murakami, Aoi Noda, Genki Shinoda, Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Yuka Kotozaki, Atsushi Shimizu, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Naoki Kondo, Shinichi Kuriyama

Translational psychiatry　2026/02/17

DOI： 10.1038/s41398-026-03896-9 　

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Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank Community-Based Cohort Study was conducted between 2013 and 2016. The participants were genotyped using the Affymetrix Axiom Japonica Array. The LSNS-6 was used to assess familial and friend ties through six questions and social isolation statuses were defined using the total scale, family subscale, and friend subscale. Genome-wide association studies (GWASs) were conducted using a generalized linear mixed model, adjusting for age, sex, 10 genetic principal components and batch effects. In total, 63,497 participants who completed genotyping and the LSNS-6 were included. The mean age was 59.4 ± 11.9 years, and 41,126 (64.8%) were female. Significant genetic loci were identified in GWASs for the total scale (rs10736933 near ACADSB and HMX3) and friend subscale of LSNS-6 (rs1778366 near LINC02315 and LRFN5). This study provides the first genome-wide evidence of social isolation in the Japanese population, suggesting associations with ACADSB, HMX3, LINC02315, and LRFN5. These findings could enable personalized prevention and intervention for social isolation and related psychiatric disorders.
Genome-wide Association Study of Subcortical Brain Structures in Japanese Ancestry: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study Peer-reviewed

Genki Shinoda, Hisashi Ohseto, Taku Obara, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Aoi Noda, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Rieko Hatanaka, Ippei Chiba, Masato Takase, Akira Narita, Tomoki Kyosaka, Shunji Mugikura, Naoko Mori, Nobuo Fuse, Atsushi Hozawa, Kyoko Suzuki, Shinichi Kuriyama

2026/02/12
Publisher: Springer Science and Business Media LLC
DOI： 10.21203/rs.3.rs-8692327/v1 　

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Abstract Subcortical brain volumes have been extensively mapped by genome-wide association studies (GWASs) in Europeans, but their genetic architecture in East Asians remains unclear. We conducted GWASs on magnetic resonance imaging derived volumes of eight subcortical structures in 9,225 Japanese participants aged 21.6–88.0 years (mean 54.0 ± 15.5 years) from the Tohoku Medical Megabank Brain MRI Study. Genotyping used Japonica Array and volumes were estimated with FreeSurfer. GWASs were performed separately in the discovery ( n = 7,328) and replication ( n = 1,897) studies, followed by a meta-analysis. We identified nine significant genome-wide loci in the discovery study, three of which were replicated. Meta-analysis revealed four additional significant loci. We identified three novel variants associated with the volumes of subcortical structures. Previously reported loci in European ancestry studies, including ALPL , SMIM19 , CHRNB3 , DSCAML1 , KTN1 , RPL13AP3 , and DCC , were replicated, leading to the identification of ancestry-specific signals. Functional mapping and expression analyses revealed brain-specific enrichment of genes associated with the caudate and putamen. This first GWAS of subcortical volumes in a Japanese population refines the genetic architecture of these structures and provides insight into mechanisms of brain aging and neuropsychiatric disease.
Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study. International-journal Peer-reviewed

Changrong Duan, Zhiqian Yu, Xue Li, Mai Sakai, Yuko Maejima, Kenju Shimomura, Tomoyuki Furuyashiki, Saya Kikuchi, Natsuko Kobayashi, Kazuto Sasaki, Tasuku Matsuki, Hiroshi Komatsu, Mizuki Hino, Yasuto Kunii, Tomoko Kasahara, Mami Ishikuro, Keiko Murakami, Masatsugu Orui, Takaaki Abe, Fuji Nagami, Nobuo Fuse, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Naoki Nakaya, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama, Hiroaki Tomita

Molecular psychiatry　2026/02/04

DOI： 10.1038/s41380-026-03456-z 　

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Maternal perinatal depression (MPD) is associated with reduced maternal plasma oxytocin (OXT) levels and an increased risk of autism spectrum disorder (ASD) in offspring. Using data from 23,218 Japanese mother-child pairs, we evaluated the relationship between MPD-assessed with the Kessler Psychological Distress Scale (K6) and the Edinburgh Postnatal Depression Scale (EPDS)-and autistic-related traits (ART) in toddlers, measured by the Tokyo Autistic Behavior Scale (TABS). We also tested the potential causal relationship of maternal stress exposure on OXT, its receptor (OXTR), and offspring outcomes using a prenatal stress-exposed mouse model. In the human cohort study, higher K6 or EPDS scores during pregnancy and postpartum were significantly associated with increased TABS scores in toddlers. Offspring of mothers with MPD (K6 or EPDS score ≥ 9) during pregnancy or postpartum exhibited a higher risk of ART (TABS score ≥ 15; P < 0.05). This risk was particularly pronounced in female toddlers exposed to MPD during pregnancy and postpartum (ORs: 5.805-9.367; P < 0.05). Female toddlers born to mothers with MPD also had lower birth weight, and their ART were positively correlated with K6 scores during mid-gestation and with impaired maternal bonding postpartum. In the mouse model, chronically stressed dams displayed depressive-like behaviors, and their female juveniles exhibited increased self-grooming and impaired social interaction. Furthermore, OXTR mRNA levels were significantly reduced in the prefrontal cortex of female juveniles from stressed dams. These findings suggest that MPD increases the risk of ART, particularly in females, highlighting potential sex-specific mechanisms underlying ASD susceptibility.
Bidirectional Associations of Screen Time with Externalizing and Internalizing Behaviors in Children: A Random Intercept Cross-Lagged Panel Model. International-journal Peer-reviewed

Ippei Takahashi, Taku Obara, Midori Yamamoto, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Fuji Nagami, Atsushi Hozawa, Tomoko Nishimura, Kenji J Tsuchiya, Kenichi Sakurai, Shinichi Kuriyama

American journal of epidemiology　2026/02/02

DOI： 10.1093/aje/kwag023 　

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We aimed to examine the longitudinal and directional associations of children's screen time (ST) with their extensive behavior scales at ages 2, 3, 4, and 5. This study was a part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Information was gathered prospectively, and 7,747 mother-child pairs were included. Analyses using random-intercept cross-lagged panel models were performed for children aged 2, 3, 4, and 5 years. Information on children's ST at ages 2, 3, 4, and 5 was collected from questionnaires completed by caregivers. We assessed children's behavior using the Child Behavior Checklist for Ages 1½-5 at aged 2, 3, 4, and 5 years. This study targeted scores on externalizing behavior and its 2 subscales (aggressive behavior and attention problems), and internalizing behavior and its 4 subscales (withdrawal, somatic complaints, anxious/depressed, and emotional responses). As a result, higher than expected screen time at age 2 was consistently associated with all behavioral scales at age 3. At later ages, specific bidirectional associations were identified for each behavioral scale and age group. These findings may offer preliminary guidance for future discussions on age-appropriate screen use recommendations and family media practices.
Distribution of axial length in Japanese children and adolescents aged 4 to 19 years. Peer-reviewed

Shunsuke Fujioka, Naoko Takada, Sayaka Yoshida, Mami Ishikuro, Masayuki Kobayashi, Genki Shinoda, Aoi Noda, Masatsugu Orui, Taku Obara, Satoru Tsuda, Noriko Himori, Akiko Hanyuda, Ryo Kawasaki, Shinichi Kuriyama, Nobuo Fuse, Toru Nakazawa

Japanese journal of ophthalmology　2026/01/19

DOI： 10.1007/s10384-026-01328-1 　

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PURPOSE: To investigate the distribution of axial length (AL) and the prevalence of long axial length (LAL) in Japanese children and adolescents. STUDY DESIGN: cross-sectional observational study METHODS: We analyzed AL data from 14,482 participants (7,457 boys and 7,025 girls) aged 4-19 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. AL was measured using a non-contact optical axis measurement device. We evaluated the distribution of AL in the participants with box plots for age. Segmented regression identified age-related trends and breakpoints. We calculated the age-specific proportions of participants with AL ≥ 24.5 mm and those with AL ≥ 26 mm, defined as LAL, which were considered indicative of suspected myopia. RESULTS: Mean AL increased with age, with a break point at 11.73 years. The slope before the break point was β = 0.27, while the slope after the break point decreased to β = 0.12. Boys showed earlier break point (9.87 years) than girls (15.91 years). Proportions with AL ≥ 24.5mm and ≥26mm began to increase approximately at 8 and 10 years of age respectively, with sex differences noted between ages 7 to 10 years and 10 to 11 years. CONCLUSION: This was the first large-scale AL survey in Japan and revealed the age and sex related distribution of AL and the proportion with LAL among Japanese children and adolescents aged 4 to 19 years.
Psychosocial Experiences and Coping After the 2025 Myanmar Earthquake: A Qualitative Study of Directly and Indirectly Affected Adults

Yin May Zin Han, Kyaw Zaww, Phue Thet Khaing, Moe Sandar Kyaw, Kaung Myat Thwin, Masatsugu Orui, Yasuto Kunii, Yumiko Hamaie, Soe San Kyaw, Motohiro Tsuboi, Shinichi Egawa

2026

DOI： 10.2139/ssrn.7383652 　
Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization Peer-reviewed

Rieko Hatanaka, Naoki Nakaya, Sayuri Tokioka, Ippei Chiba, Taku Obara, Hirohito Metoki, Masahiro Kikuya, Kotaro Nochioka, Masatsugu Orui, Kai Susukita, Masato Takase, Ikumi Kanno, Mana Kogure, Kumi Nakaya, Mami Ishikuro, Satoshi Nagaie, Soichi Ogishima, Yohei Hamanaka, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsuhi Hozawa

Circulation Reports　2025/12/26
Publisher: Japanese Circulation Society
DOI： 10.1253/circrep.cr-25-0263 　

eISSN： 2434-0790
Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Mustakim, Mami Ishikuro, Chikana Kawaguchi, Genki Shinoda, Aoi Noda, Masatsugu Orui, Keiko Murakami, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Journal of developmental origins of health and disease　16　e46　2025/12/15

DOI： 10.1017/S2040174425100305 　

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Small-for-gestational age (SGA) is an important global public health issue because of its increasing prevalence and long-term effects. Maternal smoking is a known risk factor for SGA; however, the effect of grandmaternal smoking on the risk of SGA in grandchildren SGA remains unclear. In this study, we examined whether grandmaternal smoking during pregnancy was associated with small birth weight, length, and head circumference for gestational age. Data were obtained from 23,730 pregnant women and their offspring from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Studies. A total of 1,130 grandmaternal-maternal-child triads were identified. Grandmaternal smoking during pregnancy was defined by the Maternal and Child Health Handbook owned by the mothers at birth mothers when they were born. Birth outcomes of grandchildren were obtained from medical records and converted to SGA using the 10th percentile for weight, length, and head circumference. A multivariate logistic regression and propensity scores were used for the analysis. Prevalence of <10th percentile for birth weight, length, and head circumference in grandmaternal smokers were 10.2%, 2.0%, and 10.2%, respectively. Grandmaternal smoking during pregnancy was associated with the lower grandchild's birth weight (odds ratio (OR) [95% (CI)]: 2.86 [1.05-7.82]) and remained consistent when adjusted by propensity score (OR [95% CI]: 2.87 [1.04-7.92]). Grandmaternal smoking should not be ignored when assessing the SGA risk. Future work should consider the complex mediating relationship between smoking and growth restriction across generations.
Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study. International-journal Peer-reviewed

Chikashi Iwasaki, Kumi Nakaya, Mitsuhiro Yamada, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Masato Takase, Sayuri Tokioka, Taku Obara, Masatsugu Orui, Naoya Fujino, Akira Koarai, Tomoko Kobayashi, Yohei Hamanaka, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Nobuo Fuse, Shinichi Kuriyama, Hisatoshi Sugiura, Atsushi Hozawa

Respiratory investigation　64　(1)　101343-101343　2025/12/04

DOI： 10.1016/j.resinv.2025.101343 　

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BACKGROUND: Preserved ratio impaired spirometry (PRISm), defined as a forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio ≥0.70 and a predicted FEV1 <80 %, is associated with increased morbidity and mortality. However, determinants of PRISm, particularly in younger populations, remain poorly characterised. We aimed to address this knowledge gap. METHODS: We conducted a cross-sectional analysis of 12,350 participants from a Japanese community-based cohort using data from the Tohoku Medical Megabank Project. Participants underwent spirometry, blood pressure measurement, laboratory testing, and completed standardised questionnaires. Multivariate logistic regression was used to identify factors associated with PRISm across three age groups: 20-39, 40-59, and ≥60 years. Interactions between age groups and other explanatory variables were assessed. RESULTS: In the 20-39-year group, PRISm was independently associated with being men, diabetes mellitus, hypothyroidism, and low body mass index (BMI <18.5 kg/m2), and inversely associated with age. Among participants aged ≥60 years, PRISm was significantly associated with increasing age, overweight status (BMI ≥25.0-<30.0 kg/m2), being men, current smoking, hypertension, diabetes mellitus, bronchial asthma, elevated eosinophil counts (≥300 cells/μL), and birth weight ≥2000-<2500 g. Significant interactions were observed between age and BMI, bronchial asthma, and thyroid dysfunction. CONCLUSIONS: Our findings indicate that PRISm in younger adults is associated with hypothyroidism and underweight status, whereas in older adults, it is more closely related to constitutional and lifestyle-related factors. These results highlight the heterogeneity of PRISm and indicate that its pathophysiology and optimal management may vary by age group.
The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women. International-journal Peer-reviewed

Hisashi Ohseto, Mami Ishikuro, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama

Placenta　172　100-103　2025/12

DOI： 10.1016/j.placenta.2025.10.017 　

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The placenta plays a crucial role in preeclampsia (PE) pathogenesis, with early onset (EOPE) and late onset (LOPE) presenting with unique manifestations. In this prospective study of 17,709 pregnant Japanese women, the relationship between the PE subtype and birth weight to placental weight ratio (BW/PW ratio) was examined. EOPE was not associated with BW/PW ratio, which was consistent with reduced birth and placental weights. LOPE showed lower BW/PW ratios, indicating potential adaptive hypertrophy of the placenta. These results emphasize the consideration of PE subtypes when utilizing the BW/PW ratio as an index of placental function and to elucidate PE mechanisms.
Risk of Major Congenital Malformations Associated With First-Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study. International-journal Peer-reviewed

Tadaharu Kunitoki, Takamasa Sakai, Tomofumi Ishikawa, Ryo Obara, Kei Morishita, Azusa Hara, Motohiko Adomi, Haruto Watanabe, Kaya Hayasaka, Yuna Yoshida, Aki Shimizu, Genki Shinoda, Aoi Noda, Mami Ishikuro, Masatsugu Orui, Noriyuki Iwama, Seiko Yamakoshi, Emiko Sato, Nariyasu Mano, Shinichi Kuriyama, Nobuyuki Takahashi, Taku Obara

Pharmacoepidemiology and drug safety　34　(12)　e70274　2025/12

DOI： 10.1002/pds.70274 　

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PURPOSE: Vulvovaginal candidiasis is highly prevalent among pregnant women, and its treatment is crucial. However, there is a lack of evidence regarding the risks on fetal outcomes associated with the use of antifungal medications during the first trimester of pregnancy in Japan. This study examined the association between topical antifungal use during the first trimester of pregnancy and the risk of major congenital malformations (MCMs) in infants using a Japanese database. METHODS: We conducted a cohort study using a pregnancy cohort nested in the JMDC Claims Database from Japan. This dataset included 12 472 women who gave birth between 2010 and 2019 and were diagnosed with vulvovaginal candidiasis. Among the antifungal medications frequently dispensed or prescribed during the first trimester of pregnancy in this cohort, miconazole, oxiconazole, and isoconazole were assessed for the risk of MCMs, using clotrimazole, an antifungal medication with established safety during pregnancy, as a reference. RESULTS: Among 12 472 women, the overall prevalence of MCMs was 5.8% (n = 249) in women exposed to topical antifungals, while unexposed were 6.2% (n = 508). Using propensity score overlap weight (wOR), no increased risk of MCMs in infants was observed in pregnancies exposed to oxiconazole, isoconazole, and miconazole compared to clotrimazole (overlap weighted odds ratio [95% confidence interval]: 0.875 [0.599-1.277], 1.001 [0.611-1.640], and 0.887 [0.497-1.581], respectively). CONCLUSION: There was no significant association between topical antifungal use during the first trimester of pregnancy and the risk of MCMs in infants in Japan.
Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention Peer-reviewed

Masatsugu Orui, Mana Kogure, Yuka Kotozaki, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Yoshitake Takebayashi, Masaharu Maeda, Naoki Nakaya, Kozo Tanno, Atsushi Hozawa, Shinichi Kuriyama

JMA JOURNAL　2025/11/28

DOI： 10.31662/jmaj.2025-0257 　

ISSN： 2433-328X

eISSN： 2433-3298
A Remote Access Qualitative Study Protocol to Investigate the Coping Strategies in the Mindset of the Affected Adults after the 2025 Myanmar Earthquake. Peer-reviewed

Phue Thet Khaing, Yin May Zin Han, Kyaw Zaww, Moe Sandar Kyaw, Kaung Myat Thwin, Masatsugu Orui, Yasuto Kunii, Yumiko Hamaie, Soe San Kyaw, Motohiro Tsuboi, Shinichi Egawa

The Tohoku journal of experimental medicine　267　(3)　263-272　2025/11/22

DOI： 10.1620/tjem.2025.J130 　

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On March 28, 2025, a 7.7-magnitude earthquake struck central Myanmar (GLIDE #EQ-2025-000043-MMR), compounding the country's existing political instability, economic fragility, and infrastructural weaknesses. Although seismic events have recurred throughout history, limited knowledge exists regarding how working-age adults (18-60), who play a central role in recovery, mobilize personal, cultural, and community resources to cope with adversity and reconstruct their lives. This is a protocol clarification for a remote access qualitative study using semi-structured interviews with 30 purposively sampled participants, half from heavily impacted zones (Sagaing, Mandalay) and half from nearby regions experiencing secondary disruption (Yangon). Using a remote system, interviews will be audio-recorded, transcribed verbatim, and analyzed thematically following Graneheim and Lundman's approach. This study aims to identify key coping strategies, including social support networks, spiritual practices, and local initiatives of working-age adults in Myanmar, and to compare how exposure severity shapes adaptive responses. Anticipated themes based on existing disaster and resilience literature include community-led resilience, hope through faith, and resource-sharing practices. Findings are expected to offer in-depth, culturally grounded insights that can inform disaster recovery programs, psychosocial support services, and policy frameworks aimed at strengthening resilience in Myanmar and similar low-resource, low-accessibility, crisis-affected settings.
Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study. International-journal Peer-reviewed

Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Masato Takase, Yuka Kotozaki, Taku Obara, Satoshi Nagaie, Hideki Ohmomo, Takahito Nasu, Michihiro Satoh, Takahisa Murakami, Hirohito Metoki, Yohei Hamanaka, Masatsugu Orui, Eiichi N Kodama, Nobuo Fuse, Yoko Izumi, Kozo Tanno, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2025/11/12

DOI： 10.1038/s41440-025-02436-0 　

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Antihypertensive therapy has reduced cardiovascular mortality; however, challenges remain, including residual risk in treated patients and the population burden associated with borderline hypertension. Previous Japanese estimates of the population attributable fraction (PAF) are derived from older cohorts and often lacked stratification by treatment status. We conducted a prospective study of 61,495 participants (women: 56.7%, aged 60.7 ± 11.0 years) from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were classified into six blood pressure (BP) categories based on the JSH 2019 guidelines, and further stratified by hypertension treatment status, resulting in 12 groups. Using untreated individuals with normal BP as the reference, we calculated multivariable-adjusted hazard ratios (HR), 95% confidence intervals (CI), and PAF for the remaining groups using Cox proportional hazards model. During a median follow-up of 6.5 years, 1909 deaths were recorded. HRs increased with rising BP in both untreated and treated participants. The overall PAF for all-cause mortality due to non-normal BP was 9.45%, with a marked sex difference (12.25% in male and 5.16% in female). The highest PAF contributions were observed in the treated Grade I hypertension group (2.18%) and the untreated elevated BP group (1.28%). In this contemporary Japanese cohort, non-normal BP accounts for 9.45% of all-cause mortality, representing a substantial public health burden, particularly among men. The substantial PAF contributions from both treated patients and untreated individuals with elevated BP highlight the importance of effective BP management for both primary and secondary prevention.
Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy. International-journal Peer-reviewed

Geng Chen, Mami Ishikuro, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

JAMA network open　8　(11)　e2545719　2025/11/03

DOI： 10.1001/jamanetworkopen.2025.45719 　

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IMPORTANCE: Exposure to hypertensive disorders of pregnancy (HDP) during the fetal stage has been linked to developmental delays in children. However, the associations between HDP subtypes and longitudinal patterns in child development remain unclear. OBJECTIVE: To investigate the associations of HDP subtypes with child developmental patterns. DESIGN, SETTING, AND PARTICIPANTS: This study used data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study recruiting pregnant individuals in Japan between July 2013 and March 2017. Mother-child pairs were included in the analysis. The data analysis was conducted from November 2023 to February 2024. EXPOSURES: HDP and its subtypes (gestational hypertension and preeclampsia) were identified using an algorithm applied to antenatal visit records. MAIN OUTCOMES AND MEASURES: The latent class trajectory model was applied to child development scores at ages 6, 12, 24, 42, and 48 months to generate patterns in 5 domains (communication, gross motor, fine motor, problem solving, and personal-social). Multinomial Poisson regression analysis calculated the risk ratios (RRs) of different developmental patterns by exposure to any HDP as well as HDP subtypes. A subgroup analysis was performed by preterm birth. RESULTS: Among 14 023 mother-child pairs (maternal mean [SD] age, 32.5 [4.8] years; 6754 [48.2%] female children), 1406 (10.0%) were exposed to HDP. Three patterns were identified in the 5 domains: normal, delay, and catch-up. Point estimates for delays in multiple domains of development were greater for any HDP, preeclampsia, and early-onset preeclampsia, but not all findings were statistically significant. Early-onset preeclampsia was associated with a significantly higher risk of delay pattern in problem solving domain (RR, 2.90; 95% CI, 1.43-5.89; adjusted P = .047), although the risks of delay pattern were not statistically significant in communication (RR, 1.94; 95% CI, 1.14-3.29; adjusted P = .15), gross motor (RR, 2.10; 95% CI, 1.26-3.51; adjusted P = .06), or fine motor (RR, 2.68; 95% CI, 1.26-5.71; adjusted P = .11) domains. In the term-born population, children exposed to preeclampsia and had an RR greater than 1 for the delay pattern in the problem solving domain (RR, 1.67; 95% CI, 1.92-2.74; adjusted P = .60), although this finding was not statistically significant after adjusting for multiple comparisons. CONCLUSIONS AND RELEVANCE: In this cohort study, fetal exposure to early-onset preeclampsia was associated with higher risk of a delayed child developmental pattern in the problem solving domain. The observations were modified by preterm birth. These findings suggest that children exposed to certain HDP subtypes during fetal life require developmental monitoring, especially if they were born preterm.
Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy. International-journal Peer-reviewed

Aoi Noda, Ryutaro Arita, Taku Obara, Minoru Ohsawa, Satoko Suzuki, Ken Haneda, Ryo Obara, Kei Morishita, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Shinichi Kuriyama

Pharmacoepidemiology and drug safety　34　(11)　e70251　2025/11

DOI： 10.1002/pds.70251 　

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PURPOSE: Japanese traditional (Kampo) medicines containing ephedra are used to relieve symptoms of the common cold during pregnancy. The risks associated with perinatal outcomes, however, remain unclear. Thus, we evaluated the risk of adverse perinatal outcomes associated with the use of Kampo medicines containing ephedra during pregnancy using data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women who participated in the TMM BirThree Cohort Study at approximately weeks 12 and 26 of pregnancy. Adverse perinatal outcomes in women who used Kampo medicines containing ephedra or acetaminophen during pregnancy were assessed. Odds ratios (ORs) were estimated using weighted logistic regression analyses. RESULTS: Among 20 083 pregnant women, acetaminophen and Kampo medicines containing ephedra were used by 5.3% and 3.5% of women, respectively. The OR for caesarean section was 0.95 (95% confidence interval [CI], 0.75-1.20), for preterm birth (PTB) was0.99 (95% CI, 0.63-1.55), for low birth weight (LBW) was 1.04 (95% CI, 0.72-1.49), for small for gestational age (SGA) was 0.98 (95% CI, 0.58-1.65), and for low Apgar scores at 5 min was 0.85 (95% CI, 0.25-2.93) in the women who used Kampo medicines containing ephedra during pregnancy. CONCLUSIONS: No statistically significant association was seen between the use of Kampo medicines containing ephedra during pregnancy and an increased risk of needing a caesarean section, PTB, LBW, SGA, or low Apgar scores. Although further research is needed, this study may assist in clinical decision-making.
Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study. International-journal Peer-reviewed

Ami Uematsu, Masatsugu Orui, Mami Ishikuro, Keiko Murakami, Aoi Noda, Genki Shinoda, Taku Obara, Shinichi Kuriyama

Clinical and experimental pediatrics　2025/10/22

DOI： 10.3345/cep.2025.01165 　

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BACKGROUND: Associations have been suggested between prenatal exposure and allergic diseases in children as well as between respiratory allergies and maternal sleep disorders during pregnancy. PURPOSE: This study aimed to examine the association between maternal sleep disorders during pregnancy and allergic diseases, including respiratory, skin, and ocular allergies, in their children. METHODS: This study was based on the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Sleep disorders during pregnancy were defined as an Athens Insomnia Scale score of ≥6. Allergic diseases in children up to 5 years of age were assessed by maternal selfreport on "bronchial asthma," "atopic dermatitis," "food allergy," and "allergic conjunctivitis/allergic rhinitis/hay fever." Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using a Cox proportional hazards model. RESULTS: A total of 11,123 mother-child pairs were included. The mean gestational age at registration was 19.6±7.6 weeks. During pregnancy, 4,115 women (37.0%) experienced sleep disorders. Additionally, 53.7% of the participants had a history of parity, 8.8% worked night shifts, and 0.4% used sleep medications. In the crude models, maternal sleep disorders during pregnancy were associated with all examined allergic diseases in children. After the adjustment for all confounders, the associations remained significant for atopic dermatitis and allergic conjunctivitis/ allergic rhinitis/hay fever (HR [95% CI], 1.09 [0.97-1.23] for bronchial asthma, 1.17 [1.05-1.31] for atopic dermatitis, 1.11 [0.98-1.26] for food allergy, and 1.25 [1.13-1.39] for allergic conjunctivitis/allergic rhinitis/hay fever). CONCLUSION: Maternal sleep disorders during pregnancy were associated with atopic dermatitis as well as allergic conjunctivitis/allergic rhinitis/hay fever in children.
Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. International-journal Peer-reviewed

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Ikumi Kanno, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Clinical kidney journal　18　(10)　sfaf275　2025/10

DOI： 10.1093/ckj/sfaf275 　

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BACKGROUND: Whether adherence to a healthy lifestyle can mitigate genetic risk for renal dysfunction remains unclear. METHODS: This prospective cohort study included 12 680 adults aged ≥20 years, free from chronic kidney disease at baseline, enrolled in the Tohoku Medical Megabank Community-based Cohort study. A healthy lifestyle score-based on normal weight, never smoking, never drinking, regular physical activity, and a low urinary sodium-to-potassium ratio-classified participants into ideal, intermediate, or poor lifestyle groups. A polygenic risk score (PRS) was constructed using estimated glomerular filtration rate (eGFR) data from a previous multi-ancestry genome-wide association meta-analysis. The primary outcome was renal dysfunction, defined as eGFR <60.0 ml/min/1.73 m2. RESULTS: Among the 12 680 adults, 123 participants (0.9%) developed renal dysfunction during a mean follow-up of 4.4 ± 0.8 years. Poor lifestyle was consistently associated with higher risk of renal dysfunction across most PRS categories. Participants with intermediate genetic risk had elevated risk only when also exhibiting an intermediate lifestyle. Formal testing for effect modification by PRS provided modest evidence that the association between high genetic risk and increased risk of renal dysfunction was stronger among individuals with an intermediate lifestyle. Although the addition of the PRS to the model included the C-statistic, this improvement was not statistically significant. CONCLUSIONS: Maintaining a healthy lifestyle is associated with lower risk of renal dysfunction, regardless of genetic risk. Combining PRSs with lifestyle information may enhance risk stratification, although further studies are needed to improve predictive accuracy.
Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study Peer-reviewed

Genki Shinoda, Taku Obara, Ippei Takahashi, Hisashi Ohseto, Chikana Kawaguchi, Akira Narita, Aoi Noda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Makiko Taira, Hiroshi Sakamoto, Naoki Nakaya, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Shunji Mugikura, Kyoko Suzuki, Shinichi Kuriyama

Genes, Brain and Behavior　2025/10

DOI： 10.1111/gbb.70038 　
Association of Quinolone Exposure in the First-Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. International-journal Peer-reviewed

Kei Morishita, Taku Obara, Tomofumi Ishikawa, Ryo Obara, Takamasa Sakai, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroshi Kawame, Nariyasu Mano, Shinichi Kuriyama

Pharmacoepidemiology and drug safety　34　(9)　e70190　2025/09

DOI： 10.1002/pds.70190 　

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PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with quinolone exposure during the first trimester of pregnancy using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to November 2019. The dates of pregnancy onset and delivery were estimated using the developed algorithm. MCMs were defined according to the International Classification of Diseases, 10th revision codes. The risk of MCM associated with first-trimester quinolone prescriptions was evaluated in women with infectious diseases diagnosed during the first trimester of pregnancy. We evaluated the overall risk of MCMs in infants, and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by comparing women with first-trimester prescriptions of quinolones with those without antibiotic prescriptions, adjusting for covariates with propensity score overlap weights. RESULTS: The prevalence of first-trimester infectious diseases was 51.6% (47 121/91390). Among 47 121 women diagnosed with infectious diseases, 1 320 were prescribed quinolones during their first trimester of pregnancy. The overall prevalence of MCMs was 6.0% (2282/37766) in women unexposed to antibiotics and 5.9% (78/1320) in those exposed to quinolones. The first-trimester prescription of quinolone was not significantly associated with the overall MCM prevalence when overlap-weighted ORs (wOR) were calculated using propensity score overlap weights for covariates (wOR 0.904, 95% CIs 0.684-1.196). CONCLUSIONS: Prescription of quinolones in the first-trimester of pregnancy was not associated with an increased risk of MCMs in infants. Our findings may support clinical decision-making when considering quinolone use during the first-trimester of pregnancy.
Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update Peer-reviewed

Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, Masatsugu Orui, Genki Shinoda, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Hiroko Matsubara, Hirohito Metoki, Masahiro Kikuya, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Mana Kogure, Naoki Nakaya, Junichi Sugawara, Shigeo Kure, Mika Kobayashi, Tomoko Kobayashi, Yoichi Suzuki, Hiroshi Kawame, Mika Sakurai-Yageta, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Satoshi Mizuno, Satoshi Nagaie, Soichi Ogishima, Akira Narita, Gen Tamiya, Sachie Koreeda, Fuji Nagami, Toru Tamahara, Maki Goto, Akihito Otsuki, Makiko Taira, Takanori Hidaka, Junko Kawashima, Eiichi N Kodama, Akira Uruno, Yohei Hamanaka, Hiroaki Tomita, Hiroaki Hashizume, Kenichi Noguchi, Fumiki Katsuoka, Seizo Koshiba, Kazuki Kumada, Takahiro Nobukuni, Kinuko Ohneda, Shunji Mugikura, Ritsuko Shimizu, Masataka Kambe, Yoshinobu Saito, Tadao Kobayashi, Yoko Izumi, Kengo Kinoshita, Nobuo Fuse, Nobuo Yaegashi, Atsushi Hozawa, Masayuki Yamamoto, Shinichi Kuriyama, Hikaru Abe, Michiaki Abe, Momoka Abe, Naomi Abe, Noriko Abe, Tomomi Abe, Yuto Abe, Shizuko Ahiko, Kayo Aiki, Hiromi Aizawa, Yukari Akiyama, Hayato Anzawa, Eri Aoki, Yuichi Aoki, Hiroko Arai, Misaki Arakawa, Yukie Asano, Liam Baird, Ayano Chiba, Haruna Chiba, Ippei Chiba, Kenji Chiba, Tetsuo Chiba, Hisako Endo, Reika Fue, Futaba Fujishiro, Yayoi Fujita, Waka Fukunaga, Mami Funata, Takamitsu Funayama, Sho Furuhashi, Nobuo Fuse, Junko Fushimi, Kumiko Fushiya, Tomomi Gamo, Chinatsu Gocho, Katsuhiro Gonoi, Maki Goto, Takahiko Goto, Yukie Goto, Kaori Gouko, Michiko Haga, Yoko Haga, Hiroko Hamada, Yumiko Hamaie, Yohei Hamanaka, Mika Hanazawa, Yukari Hara, Atsushi Hasegawa, Asuka Hatakeyama, Sumika Hatakeyama, Nozomi Hatanaka, Rieko Hatanaka, Takanori Hidaka, Kenji Hino, Hiroe Hirama, Ikuo Hirano, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Yuki Hiratsuka, Ikuko Hirayama, Eiji Hishinuma, Takako Hoshi, Atsushi Hozawa, Keisuke Ido, Nobuko Igari, Chikako Iida, Katsuko Imai, Makiko Inoue, Reiko Inoue, Rumi Irie, Motoko Ishida, Noriko Ishida, Eri Ishigaka, Chihiro Ishii, Kaori Ishii, Osamu Ishii, Tadashi Ishii, Tatsuro Ishikawa, Mami Ishikuro, Kazutoshi Ishimori, Miho Itabashi, Kumiko Ito, Maiko Ito, Masumi Ito, Mayumi Ito, Megumi Ito, Natsuko Ito, Rie Ito, Saori Ito, Fumihiko Iwabuchi, Maki Iwabuchi, Yoko Izumi, Yoshiko Izumi, Masataka Kambe, Takanari Kanno, Mayu Kano, Naoko Kasahara, Hinako Kashiwa, Kiyomi Katahira, Mayumi Kato, Yukie Kato, Fumiki Katsuoka, Takeshi Kawabata, Rika Kawada, Aoi Kawagoe, Hiroshi Kawame, Junko Kawashima, Yukako Kawashima, Junko Kikuchi, Tsuyoshi Kikukawa, Masahiro Kikuya, Masae Kimura, Michiko Kimura, Kengo Kinoshita, Ikuko Kishi, Tomoko Kishimoto, Tamie Kitaura, Mika Kobayashi, Tadao Kobayashi, Tomoko Kobayashi, Eiichi Kodama, Shun Kodate, Mana Kogure, Toshisada Kohagizawa, Naomi Kohketsu, Noa Koida, Chie Koide, Mika Koide, Toshihiko Koike, Kaname Kojima, Junko Komatsu, Ayumi Kondo, Riyo Konno, Yukie Konno, Sachie Koreeda, Seizo Koshiba, Takuya Koyama, Hisaaki Kudo, Kazuki Kumada, Ryoko Kumadaki, Rika Kumagai, Toshie Kumagai, Yuko Kumagai, Yasuto Kunii, Miho Kuriki, Shinichi Kuriyama, Emiko Kurokawa, Seiko Kurota, Hisako Kusano, Bin Li, Donghan Li, Xue Li, Kanako Maeshibu, Keiko Maeta, Satoshi Makino, Hiroko Matsubara, Naomi Matsukawa, Masako Matsumoto, Takako Matsuoka, Yuka Matsushita, Motomichi Matsuzaki, Hirohito Metoki, Sayaka Minakawa, Yuki Minami, Mirei Suzuki, Kyoko Mitate, Satomi Mito, Ayako Miura, Noriko Miura, Ryo Miyagi, Akiko Miyazawa, Satoshi Mizuno, Akiko Mochida, Mika Momii, Hiroko Mori, Naoko Mori, Hozumi Motohashi, Ikuko Motoike, Shunji Mugikura, Keiko Murakami, Takahisa Murakami, Masato Nagai, Satoshi Nagaie, Fuji Nagami, Toko Naganuma, Tatsuo Nagasaka, Sachiko Nagase, Kumiko Nakagawa, Taku Nakai, Noriko Nakajo, Kyoko Nakamichi, Chie Nakamura, Naoki Nakamura, Tomohiro Nakamura, Yuko Nakasato, Kumi Nakaya, Naoki Nakaya, Kei Nanatani, Akira Narita, Yuka Narita, Yasuhisa Nemoto, Hafumi Nishi, Kohji Nishida, Ichiko Nishijima, Momo Nishiyama, Takahiro Nobukuni, Kotaro Nochioka, Aoi Noda, Kenichi Noguchi, Kiriko Nozoe, Rie Nunokawa, Taku Obara, Tomoko Obara, Kaori Ogasawara, Satoru Ogawa, Soichi Ogishima, Natsuki Oguma, Nahoko Ohi, Namiko Ohisa, Kinuko Ohneda, Hayami Ohori, Miri Oikawa, Yumi Oikawa, Yumiko Ojima, Yumi Okada, Yasunobu Okamura, Hiroshi Okuda, Mitsuko Okuda, Ayako Okumoto, Akane Ono, Chiaki Ono, Genki Onodera, Kaname Onodera, Masako Onodera, Midori Onuma, Tomomi Onuma, Keiichiro Oohashi, Masumi Oomachi, Kazuya Ootomo, Yukie Oouchi, Masatsugu Orui, Mayumi Osada, Tamae Osanai, Reiko Ota, Noriko Otake, Sumie Otomo, Akihito Otsuki, Yoko Otsuki, Yuki Oyama, Keiko Oyamada, Yoko Ozawa, Satomi Obara, Daisuke Saigusa, Asami Saito, Hisako Saito, Kazue Saito, Manami Saito, Megumi Saito, Ritsumi Saito, Sakae Saito, Tomo Saito, Yoko Saito, Yuki Saito, Yoshinobu Saitoh, Hiroko Sakai, Masaki Sakaida, Hiroshi Sakamono, Hiromi Sakamoto, Kana Sakamoto, Mia Sakamoto, Kasumi Sakurai, Miyuki Sakurai, Rieko Sakurai, Mika Sakurai-Yageta, Kana Sasaki, Miho Sasaki, Tadashi Sasaki, Yukari Sasaki, Yukie Sasaki, Chika Sato, Hirokazu Sato, Michiyo Sato, Miho Sato, Mitsuharu Sato, Miu Sato, Naoko Sato, Reiko Sato, Satoshi Sato, Shiho Sato, Taku Sato, Yoshiko Sato, Youko Sato, Yui Sato, Michihiro Satoh, Ayako Sekiya, Mariko Seo, Yoshiko Shima, Muneaki Shimada, Atsushi Shimizu, Ritsuko Shimizu, Genki Shinoda, Nobuyuki Shirakawa, Matsuyuki Shirota, Hiroe Shoji, Ikuko Shoji, Mariko Shoji, Midori Shoji, Wakako Shoji, Satomi Someya, Shinya Sonobe, Itsumi Sou, Rie Suenaga, Yasuko Suenaga, Mayumi Suga, Rika Sugai, Junichi Sugawara, Megumi Sugawara, Michiko Sugawara, Nanako Sugawara, Saori Sugawara, Yuki Sugawara, Sachiyo Sugimoto, Airi Suzuki, Ayano Suzuki, Keiko Suzuki, Michirou Suzuki, Mikiko Suzuki, Norio Suzuki, Rie Suzuki, Ryoko Suzuki, Takafumi Suzuki, Tatsuya Suzuki, Yoichi Suzuki, Shu Tadaka, Keiko Taguchi, Nozomi Taiji, Makiko Taira, Kaori Takagi, Emi Takahashi, Harumi Takahashi, Junko Takahashi, Megumi Takahashi, Noriko Takahashi, Rieko Takahashi, Yukiko Takahashi, Mayuko Takasawa, Masato Takase, Jun Takayama, Miho Takeuchi, Sayaka Takita, Toru Tamahara, Gen Tamiya, Naomi Tamura, Akari Tanaka, Saiko Tanaka, Chihiro Tanno, Naoko Tanno, Keiko Tateno, Minoru Tateno, Chika Terui, Mihoko Toki, Sayuri Tokioka, Etsuko Tomita, Hiroaki Tomita, Mai Tomizuka, Naho Tsuchiya, Miyuki Tsuda, Tomomi Tsumuraya, Junko Tsunasawa, Issei Tsunoda, Juri Uchiya, Akiko Ueda, Yuriko Ueki, Fumihiko Ueno, Keiko Umeda, Akira Uruno, Ikuko Wada, Tomoko Wada, Mika Wagatsuma, Hitoshi Watanabe, Kanako Watanabe, Kazue Watanabe, Nobuo Yaegashi, Mika Yagyu, Etsuko Yamada, Yumi Yamaguchi-Kabata, Hiroko Yamamoto, Masayuki Yamamoto, Yukari Yamauchi, Mika Yamazaki, Jun Yasuda, Hang Yin, Hiroshi Yokota, Manami Yokoyama, Marie Yokoyama, Tomoko Yokoyama, Yuko Yoshida, Mizue Yoshino, Zhiqian Yu, Lin Zhang, Hikaru Abe, Michiaki Abe, Momoka Abe, Naomi Abe, Noriko Abe, Tomomi Abe, Yuto Abe, Shizuko Ahiko, Kayo Aiki, Hiromi Aizawa, Yukari Akiyama, Hayato Anzawa, Eri Aoki, Yuichi Aoki, Hiroko Arai, Misaki Arakawa, Yukie Asano, Liam Baird, Ayano Chiba, Haruna Chiba, Ippei Chiba, Kenji Chiba, Tetsuo Chiba, Hisako Endo, Reika Fue, Futaba Fujishiro, Yayoi Fujita, Waka Fukunaga, Mami Funata, Takamitsu Funayama, Sho Furuhashi, Nobuo Fuse, Junko Fushimi, Kumiko Fushiya, Tomomi Gamo, Chinatsu Gocho, Katsuhiro Gonoi, Maki Goto, Takahiko Goto, Yukie Goto, Kaori Gouko, Michiko Haga, Yoko Haga, Hiroko Hamada, Yumiko Hamaie, Yohei Hamanaka, Mika Hanazawa, Yukari Hara, Atsushi Hasegawa, Asuka Hatakeyama, Sumika Hatakeyama, Nozomi Hatanaka, Rieko Hatanaka, Takanori Hidaka, Kenji Hino, Hiroe Hirama, Ikuo Hirano, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Yuki Hiratsuka, Ikuko Hirayama, Eiji Hishinuma, Takako Hoshi, Atsushi Hozawa, Keisuke Ido, Nobuko Igari, Chikako Iida, Katsuko Imai, Makiko Inoue, Reiko Inoue, Rumi Irie, Motoko Ishida, Noriko Ishida, Eri Ishigaka, Chihiro Ishii, Kaori Ishii, Osamu Ishii, Tadashi Ishii, Tatsuro Ishikawa, Mami Ishikuro, Kazutoshi Ishimori, Miho Itabashi, Kumiko Ito, Maiko Ito, Masumi Ito, Mayumi Ito, Megumi Ito, Natsuko Ito, Rie Ito, Saori Ito, Fumihiko Iwabuchi, Maki Iwabuchi, Yoko Izumi, Yoshiko Izumi, Masataka Kambe, Takanari Kanno, Mayu Kano, Naoko Kasahara, Hinako Kashiwa, Kiyomi Katahira, Mayumi Kato, Yukie Kato, Fumiki Katsuoka, Takeshi Kawabata, Rika Kawada, Aoi Kawagoe, Hiroshi Kawame, Junko Kawashima, Yukako Kawashima, Junko Kikuchi, Tsuyoshi Kikukawa, Masahiro Kikuya, Masae Kimura, Michiko Kimura, Kengo Kinoshita, Ikuko Kishi, Tomoko Kishimoto, Tamie Kitaura, Mika Kobayashi, Tadao Kobayashi, Tomoko Kobayashi, Eiichi Kodama, Shun Kodate, Mana Kogure, Toshisada Kohagizawa, Naomi Kohketsu, Noa Koida, Chie Koide, Mika Koide, Toshihiko Koike, Kaname Kojima, Junko Komatsu, Ayumi Kondo, Riyo Konno, Yukie Konno, Sachie Koreeda, Seizo Koshiba, Takuya Koyama, Hisaaki Kudo, Kazuki Kumada, Ryoko Kumadaki, Rika Kumagai, Toshie Kumagai, Yuko Kumagai, Yasuto Kunii, Miho Kuriki, Shinichi Kuriyama, Emiko Kurokawa, Seiko Kurota, Hisako Kusano, Bin Li, Donghan Li, Xue Li, Kanako Maeshibu, Keiko Maeta, Satoshi Makino, Hiroko Matsubara, Naomi Matsukawa, Masako Matsumoto, Takako Matsuoka, Yuka Matsushita, Motomichi Matsuzaki, Hirohito Metoki, Sayaka Minakawa, Yuki Minami, Mirei Suzuki, Kyoko Mitate, Satomi Mito, Ayako Miura, Noriko Miura, Ryo Miyagi, Akiko Miyazawa, Satoshi Mizuno, Akiko Mochida, Mika Momii, Hiroko Mori, Naoko Mori, Hozumi Motohashi, Ikuko Motoike, Shunji Mugikura, Keiko Murakami, Takahisa Murakami, Masato Nagai, Satoshi Nagaie, Fuji Nagami, Toko Naganuma, Tatsuo Nagasaka, Sachiko Nagase, Kumiko Nakagawa, Taku Nakai, Noriko Nakajo, Kyoko Nakamichi, Chie Nakamura, Naoki Nakamura, Tomohiro Nakamura, Yuko Nakasato, Kumi Nakaya, Naoki Nakaya, Kei Nanatani, Akira Narita, Yuka Narita, Yasuhisa Nemoto, Hafumi Nishi, Kohji Nishida, Ichiko Nishijima, Momo Nishiyama, Takahiro Nobukuni, Kotaro Nochioka, Aoi Noda, Kenichi Noguchi, Kiriko Nozoe, Rie Nunokawa, Taku Obara, Tomoko Obara, Kaori Ogasawara, Satoru Ogawa, Soichi Ogishima, Natsuki Oguma, Nahoko Ohi, Namiko Ohisa, Kinuko Ohneda, Hayami Ohori, Miri Oikawa, Yumi Oikawa, Yumiko Ojima, Yumi Okada, Yasunobu Okamura, Hiroshi Okuda, Mitsuko Okuda, Ayako Okumoto, Akane Ono, Chiaki Ono, Genki Onodera, Kaname Onodera, Masako Onodera, Midori Onuma, Tomomi Onuma, Keiichiro Oohashi, Masumi Oomachi, Kazuya Ootomo, Yukie Oouchi, Masatsugu Orui, Mayumi Osada, Tamae Osanai, Reiko Ota, Noriko Otake, Sumie Otomo, Akihito Otsuki, Yoko Otsuki, Yuki Oyama, Keiko Oyamada, Yoko Ozawa, Satomi Obara, Daisuke Saigusa, Asami Saito, Hisako Saito, Kazue Saito, Manami Saito, Megumi Saito, Ritsumi Saito, Sakae Saito, Tomo Saito, Yoko Saito, Yuki Saito, Yoshinobu Saitoh, Hiroko Sakai, Masaki Sakaida, Hiroshi Sakamono, Hiromi Sakamoto, Kana Sakamoto, Mia Sakamoto, Kasumi Sakurai, Miyuki Sakurai, Rieko Sakurai, Mika Sakurai-Yageta, Kana Sasaki, Miho Sasaki, Tadashi Sasaki, Yukari Sasaki, Yukie Sasaki, Chika Sato, Hirokazu Sato, Michiyo Sato, Miho Sato, Mitsuharu Sato, Miu Sato, Naoko Sato, Reiko Sato, Satoshi Sato, Shiho Sato, Taku Sato, Yoshiko Sato, Youko Sato, Yui Sato, Michihiro Satoh, Ayako Sekiya, Mariko Seo, Yoshiko Shima, Muneaki Shimada, Atsushi Shimizu, Ritsuko Shimizu, Genki Shinoda, Nobuyuki Shirakawa, Matsuyuki Shirota, Hiroe Shoji, Ikuko Shoji, Mariko Shoji, Midori Shoji, Wakako Shoji, Satomi Someya, Shinya Sonobe, Itsumi Sou, Rie Suenaga, Yasuko Suenaga, Mayumi Suga, Rika Sugai, Junichi Sugawara, Megumi Sugawara, Michiko Sugawara, Nanako Sugawara, Saori Sugawara, Yuki Sugawara, Sachiyo Sugimoto, Airi Suzuki, Ayano Suzuki, Keiko Suzuki, Michirou Suzuki, Mikiko Suzuki, Norio Suzuki, Rie Suzuki, Ryoko Suzuki, Takafumi Suzuki, Tatsuya Suzuki, Yoichi Suzuki, Shu Tadaka, Keiko Taguchi, Nozomi Taiji, Makiko Taira, Kaori Takagi, Emi Takahashi, Harumi Takahashi, Junko Takahashi, Megumi Takahashi, Noriko Takahashi, Rieko Takahashi, Yukiko Takahashi, Mayuko Takasawa, Masato Takase, Jun Takayama, Miho Takeuchi, Sayaka Takita, Toru Tamahara, Gen Tamiya, Naomi Tamura, Akari Tanaka, Saiko Tanaka, Chihiro Tanno, Naoko Tanno, Keiko Tateno, Minoru Tateno, Chika Terui, Mihoko Toki, Sayuri Tokioka, Etsuko Tomita, Hiroaki Tomita, Mai Tomizuka, Naho Tsuchiya, Miyuki Tsuda, Tomomi Tsumuraya, Junko Tsunasawa, Issei Tsunoda, Juri Uchiya, Akiko Ueda, Yuriko Ueki, Fumihiko Ueno, Keiko Umeda, Akira Uruno, Ikuko Wada, Tomoko Wada, Mika Wagatsuma, Hitoshi Watanabe, Kanako Watanabe, Kazue Watanabe, Nobuo Yaegashi, Mika Yagyu, Etsuko Yamada, Yumi Yamaguchi-Kabata, Hiroko Yamamoto, Masayuki Yamamoto, Yukari Yamauchi, Mika Yamazaki, Jun Yasuda, Hang Yin, Hiroshi Yokota, Manami Yokoyama, Marie Yokoyama, Tomoko Yokoyama, Yuko Yoshida, Mizue Yoshino, Zhiqian Yu, Lin Zhang

International Journal of Epidemiology　2025/08/18

DOI： 10.1093/ije/dyaf148 　
Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. International-journal Peer-reviewed

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Seizo Koshiba, Kazuki Kumada, Ikuko Motoike, Eiji Hishinuma, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kinuko Ohneda, Kengo Kinoshita, Atsushi Hozawa, Masayuki Yamamoto

Cardiovascular diabetology　24　(1)　335-335　2025/08/14

DOI： 10.1186/s12933-025-02849-8 　

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BACKGROUND: No previous studies have explored metabolites associated with both genetic predispositions to type 2 diabetes (T2DM) and T2DM onset. Therefore, we aimed to explore metabolic profiles using genetic risk to identify pathways for tailored T2DM prevention strategies. METHODS: This prospective community-based cohort study in Japan included a total of 12,461 participants aged ≥ 20 years. Genetic predictors were genome-wide and pathway-based polygenic risk scores (PRSs). We quantified 43 metabolites using nuclear magnetic resonance spectroscopy. T2DM was defined as a non-fasting glucose level of ≥ 200 mg/dL, glycated hemoglobin level ≥ 6.5%, or self-reported T2DM treatment. A modified Poisson regression model was used to examine the associations of PRSs and metabolites with T2DM incidence. Linear associations were tested using the restricted cubic spline, and mediation analysis was conducted to assess the mediating effect of metabolites on the association between PRSs and T2DM incidence. RESULTS: During the 4.3-year median follow-up period, 354 T2DM cases were identified. A higher PRS was associated with incident T2DM (relative risk [RR] 2.09, 95% confidence interval [CI], 1.68-2.60, P < 0.001, 1-standard deviation [SD] increment). The nitrogen compound transport pathway PRS was associated with incident T2DM (RR 1.32, 95% CI 1.03-1.70, P < 0.001, 1-SD increment). Fourteen metabolites like glucose, 2-ketoisocaproic acid, glutamic acid, leucine, 2-aminobutyric acid, 2-hydroxybutyric acid, valine, 3-methyl-2-oxobutyric acid, alanine, 3-hydroxybutyric acid, 3-methyl-2-oxiovaleric acid, formic acid, arginine, and tyrosine were positively associated with the risk of T2DM. Only glycine was inversely associated with the risk of T2DM. Among 43 metabolites, 14 metabolites were positively associated with PRS (P for linear trend < 0.05). 3-hydroxyisobutyric-acid, 2-Aminobutyric acid, 2-ketoisocaproic acid, 2-hydroxybutyric acid, leucine, glycine, and glucose mediated the association between PRS and incident T2DM. CONCLUSIONS: Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. International-journal Peer-reviewed

Masato Takase, Takumi Hirata, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Hirohito Metoki, Michihiro Satoh, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Hypertension research : official journal of the Japanese Society of Hypertension　2025/08/13

DOI： 10.1038/s41440-025-02314-9 　

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Family history of hypertension may reflect genetic and lifestyle factors. Genetic risk can be assessed using polygenic risk score (PRS); however, whether PRS can stratify hypertension risk when combined with family history and lifestyle information is unclear. This prospective cohort study included 9,001 hypertension-free individuals aged ≥20 years from the Tohoku Medical Megabank Community-Based Cohort Study. Participants were scored on lifestyle factors, including body mass index, urinary sodium-to-potassium ratio, physical activity, alcohol consumption, and smoking at recruitment. During the mean follow-up of 4.3 years, 2822 (31.4%) cases of hypertension occurred. High genetic risk and poor lifestyle were associated with increased hypertension risk. Compared with participants with low genetic risk, ideal lifestyle, and no family history, high genetic risk significantly increased hypertension risk, even among those with ideal lifestyle and no family history (relative risk [RR] 1.28 [95% confidence interval [CI] 1.11-1.46]). Participants with low PRS, ideal lifestyle, but with family history had increased hypertension risk (RR 1.32 [95%CI 1.11-1.57]). Poor lifestyle increased hypertension risk across most genetic risk groups, regardless of family history. Integrating PRS into models with family history and lifestyle risk significantly improved predictive accuracy (area under the curve: 0.671 for family history and lifestyle risk and 0.674 for PRS integrated; P for difference <0.05). Integrating PRS with lifestyle and family history enhances the stratification of individuals at high risk for hypertension.
Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. International-journal Peer-reviewed

Yoichi Sutoh, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Shohei Komaki, Shiori Minabe, Hideki Ohmomo, Kozo Tanno, Atsushi Hozawa, Naoki Nakaya, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Makoto Sasaki, Atsushi Shimizu

American journal of human genetics　112　(8)　1852-1863　2025/08/07

DOI： 10.1016/j.ajhg.2025.06.015 　

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The atopic march lacks early identification methods for high-risk children. In this study, we assessed whether the risk of atopic diseases in infants could be predicted using a polygenic score (PGS) for total immunoglobulin E (IgE) levels. The PGS estimated using the polygenic model generated by PRS-CS was significantly correlated with log-transformed IgE levels (ρ = 0.200, p < 2.2 × 10-16). Assessment of the risk from birth to 2 years of age in a Japanese birth cohort (n = 17,154) applying the estimated PGS revealed significantly elevated incidence risk ratios in the highest PGS quintile (Q5) compared with those in the reference quintiles (Q1-Q3) for food allergy (1.51-fold; 95% confidence interval: 1.30-1.76), atopic dermatitis (1.30-fold; 1.12-1.51), and both conditions (1.88-fold; 1.46-2.43). These findings address critical gaps in allergy and PGS research among non-European populations, suggesting the contribution of genetic predisposition to IgE production in early-onset allergic diseases and supporting the use of PGS in early intervention.
Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study. Peer-reviewed

Koichi Sakakibara, Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Shinichi Kuriyama, Takeo Fujiwara, Pamela J Surkan

Journal of diabetes investigation　2025/07/08

DOI： 10.1111/jdi.70101 　

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INTRODUCTION: While social capital can prevent diabetes, these benefits can be heterogeneous with respect to socioeconomic status. We investigated the association between social capital and gestational diabetes mellitus (GDM) while examining effect modification by household income. MATERIALS AND METHODS: We conducted a secondary data analysis using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study carried out between July 2013 and March 2017. Social capital (mutual aid, social trust, informal social control, collective action) and covariates were self-reported, while GDM diagnosis and other medical and physiological information were obtained from medical records. To assess the association between social capital and GDM, we conducted logistic regression models. We further tested for interactions between social capital and household income as well as stratified the models by income. RESULTS: Among 20,339 study participants, 700 (3.4%) were diagnosed with GDM. Multivariable logistic regression models found that social trust and collective action were associated with lower GDM prevalence, even after adjustment of covariates. When stratifying household income, however, social capital was significantly associated with the reduced risks of GDM only among participants with higher household income (OR: 0.90, 95% CI: 0.85-0.97). No significant association was observed among those with lower household income. CONCLUSIONS: The health benefit of social capital on GDM prevalence was heterogeneous, and the protective effect of social capital on GDM was found only among women with higher household income. The differential impact of social capital on GDM highlights the need for targeted interventions addressing structural health inequities.
Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. Peer-reviewed

Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu Miyake, Tomohisa Suzuki, Mami Ishikuro, Masatsugu Orui, Eiichi N Kodama, Ritsuko Shimizu, Yohei Hamanaka, Yoko Izumi, Atsushi Hozawa, Nobuo Fuse, Atsuo Kikuchi, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama, Masayuki Yamamoto

The Tohoku journal of experimental medicine　2025/06/12

DOI： 10.1620/tjem.2025.J074 　
Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large-scale community-based cohort study. International-journal Peer-reviewed

Masatsugu Orui, Mami Ishikuro, Taku Obara, Aoi Noda, Genki Shinoda, Keiko Murakami, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Tomoko Nishimura, Keiko Tanaka, Yoshihiro Miyake, Atsushi Hozawa, Kenji J Tsuchiya, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　4　(2)　e70095　2025/06

DOI： 10.1002/pcn5.70095 　

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AIM: Autism spectrum disorder (ASD) is a neurodevelopmental condition clinically characterized by abnormalities in eye contact during social interactions. Eye-tracking systems have been used to screen individuals with ASD by capturing atypical eye gaze patterns of diagnostic significance, such as reduced duration of eye gaze fixation on social information. However, most prior studies have focused on the screening accuracy of eye-tracking systems in children already diagnosed with ASD, with few longitudinal assessments conducted on a large scale. This large-scale, longitudinal, community-based study aimed to analyze the association between specific neurodevelopmental symptoms and the duration of eye gaze fixation on social information within a community-based setting. METHODS: A longitudinal study involving 2101 participants utilized a generalized linear model (GLM) to examine associations between the duration of eye gaze fixation on social information at age 4 years and subscale scores of the Strengths and Difficulties Questionnaire (SDQ) at ages 6-7. RESULTS: GLM analysis revealed that shorter durations of eye gaze fixation on social information at age 4 years were significantly associated with emotional problems and peer problems, and with hyperactivity/inattention attention-deficit hyperactivity disorder (ADHD) at ages 6-7 years. CONCLUSION: These findings demonstrate the ability to detect not only peer problems characteristic of ASD but also hyperactivity/inattention characteristic of ADHD longitudinally, which it might be related to the comorbidity of ASD and ADHD. This preliminary study highlights the potential for neurodevelopmental screening; however, further research is needed to validate the accuracy of these methods.
Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. International-journal Peer-reviewed

Hisashi Ohseto, Mami Ishikuro, Geng Chen, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama

Scientific reports　15　(1)　18924-18924　2025/05/29

DOI： 10.1038/s41598-025-03652-x 　

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Adverse pregnancy outcomes (APOs) affect approximately 20% pregnant women, and their incidence is increasing. The aim of this study was to investigate the effect of cardiovascular health (CVH) during pregnancy on APOs. We analyzed data from 14,930 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. CVH status during pregnancy was assessed using the eight components of Life's Essential 8. APOs were defined as composite outcomes encompassing preeclampsia, gestational diabetes mellitus, preterm birth, and small for gestational age. The numbers of participants with high, moderate, and low CVH status were 2891 (19.4%), 11,498 (77.0%), and 541 (3.6%), respectively. Poisson regression analyses with robust error variance, which adjusted for maternal age at conception, alcohol consumption, conception via in vitro fertilization, parity, psychological distress, social isolation, and household income, showed a positive association between moderate and low CVH levels and APOs (risk ratio and 95% confidence interval 1.15 [1.03-1.28] and 2.14 [1.78-2.58], respectively). Among pregnant women with low CVH, those who reported social isolation had a higher prevalence of APOs than did those without social isolation (36.4% vs. 27.4%). This difference was attenuated for pregnant women with high CVH status (13.6% vs. 13.1%). In conclusion, CVH status may be useful for assessing the risk of APOs. Socially isolated pregnant women are more vulnerable to the effects of low CVH status.
Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis. Peer-reviewed

Motoi Sawahashi, Yoichi Kakuta, Takeo Naito, Soshi Okazaki, Kinuko Ohneda, Masatsugu Orui, Taku Obara, Soichi Ogishima, Kazuki Kumada, Hisaaki Kudo, Fuji Nagami, Atsushi Hozawa, Hideya Iwaki, Hiroshi Nagai, Yusuke Shimoyama, Rintaro Moroi, Hisashi Shiga, Yoshitaka Kinouchi, Tsuyoshi Shirai, Hiroshi Fujii, Atsushi Masamune

Journal of gastroenterology　2025/05/15

DOI： 10.1007/s00535-025-02263-7 　

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BACKGROUND: A method for predicting ulcerative colitis (UC) onset has not been established. Serum autoantibodies have been suggested as potential predictive biomarkers for UC onset. We aimed to validate the risks associated with serological and environmental factors and construct a model for predicting UC development. METHODS: Using the population-based cohort studies (n > 83,000), we identified 42 individuals who were diagnosed with UC later in life and compared them with matched healthy controls. We analyzed serum anti-integrin αvβ6 antibody (anti-αvβ6) and anti-endothelial protein C receptor antibody (anti-EPCR) titers, and lifestyle and dietary habits to explore UC onset predictors. The predictive performance of the models was evaluated based on these predictors. RESULTS: The sensitivity and specificity of anti-EPCR for predicting UC onset were 51.4% and 97.8%, respectively, comparable to those of anti-αvβ6 (52.5% and 97.6%, respectively). The proportion of individuals with insomnia was significantly higher in the preclinical UC group (adjusted odds ratio = 2.14, 95% confidence interval [CI] 1.11-4.04, p = 0.019). The predictive performance of anti-EPCR alone was high with an area under the curve (AUC) of 0.89 (95%CI 0.83-0.96), and that of anti-EPCR combined with anti-αvβ6 was even better with an AUC of 0.92 (95%CI 0.87-0.97); the lifestyle model had lower predictive accuracy (AUC = 0.65, 95%CI 0.55-0.74). CONCLUSIONS: Anti-EPCR and anti-αvβ6 each strongly predict UC onset. The combined anti-EPCR and anti-αvβ6 model had stronger predictive performance than the single models.
Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study Peer-reviewed

Mami Ishikuro, Nobuo Fuse, Taku Obara, Aoi Noda, Genki Shinoda, Masatsugu Orui, Akira Uruno, Sayaka Yoshida, Naoko Takada, Shunsuke Fujioka, Takayuki Nishimura, Akiko Hanyuda, Ryo Kawasaki, Toru Nakazawa, Shinichi Kuriyama

AJO International　2　(1)　2025/04/28

DOI： 10.1016/j.ajoint.2024.100088 　

eISSN： 2950-2535
Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. International-journal Peer-reviewed

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Akira Narita, Ippei Takahashi, Genki Shinoda, Aoi Noda, Keiko Murakami, Masatsugu Orui, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

Scientific reports　15　(1)　13743-13743　2025/04/21

DOI： 10.1038/s41598-025-97291-x 　

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Genomic information from pregnant women and the paternal parent of their fetuses may provide effective biomarkers for preeclampsia (PE). This study investigated the association of parental polygenic risk scores (PRSs) for blood pressure (BP) and PE with PE onset and evaluated predictive performances of PRSs using clinical predictive variables. In the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, 19,836 participants were genotyped using either Affymetrix Axiom Japonica Array v2 (further divided into two cohorts-the PRS training cohort and the internal-validation cohort-at a ratio of 1:2) or Japonica Array NEO (external-validation cohort). PRSs were calculated for systolic BP (SBP), diastolic BP (DBP), and PE and hyperparameters for PRS calculation were optimized in the training cohort. PE onset was associated with maternal SBP-, DBP-, and PE-PRSs and paternal SBP- and DBP-PRSs only in the external-validation cohort. Meta-analysis revealed overall associations with maternal PRSs but highlighted significant heterogeneity between cohorts. Maternal DBP-PRS calculated using "LDpred2" presented the most improvement in prediction models and provided additional predictive information on clinical predictive variables. Paternal DBP-PRS improved prediction models in the internal-validation cohort. In conclusion, Parental PRS, along with clinical predictive variables, is potentially useful for predicting PE.
Sex difference in genetic risk in the prevalence of atrial fibrillation. International-journal Peer-reviewed

Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Heart rhythm　2025/03/23

DOI： 10.1016/j.hrthm.2025.03.1974 　

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BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: The purpose of this study was to assess the sex difference in the effect of polygenic risk score for AF (AF-PRS) on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: AF-PRS and Cohorts for Heart and Aging Research in Genomic Epidemiology Atrial Fibrillation (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age 63.4 years; 5182, 30.7% men), the prevalence of AF was 255 (4.9%) in men and 130 (1.1%) in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared with that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the receiver operating characteristic curve for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. International-journal Peer-reviewed

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara

Journal of human genetics　2025/03/21

DOI： 10.1038/s10038-025-01330-4 　

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Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10-9) and rs140353742 (p = 1.24 × 10-8), located in an intron of the MDFIC2 gene, as being associated with an increased risk of GDM. Additionally, although there were suggestive patterns for interactions between these SNPs and both dietary factors (e.g., carbohydrate and fruit intake) and psychological distress, none of the interaction terms remained significant after Bonferroni correction (p < 0.05/8). While nominal significance was observed in some models (e.g., psychological distress, p = 0.04), the data did not provide robust evidence of effect modification on GDM risk once adjusted for multiple comparisons. These findings reveal novel genetic associations with GDM in Japanese women and highlight the importance of gene-environment interactions in its etiology. Given that previous genome-wide association studies (GWAS) on GDM have primarily focused on Western populations, our study provides new insights by examining an Asian population using a population-specific array.
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. International-journal Peer-reviewed

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

Nutrition (Burbank, Los Angeles County, Calif.)　135　112739-112739　2025/03/08

DOI： 10.1016/j.nut.2025.112739 　

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OBJECTIVES: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk are important in child growth, information is limited regarding which lipids are involved in AR. The object of this study was to explore the association between breast milk lipids and AR status in children. METHODS: We designed a case-control study of 184 mother-child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Breast milk was collected 1 month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children. RESULTS: We detected 667 lipid molecules in 12 lipid classes in breast milk. Partial least square-discriminant analysis revealed the association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that in pairs with exclusive breastfeeding at 1 month postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) was positively associated with early AR, and ChE (odds ratio 0.55 [95% confidence interval, 0.36-0.86]) was negatively associated. CONCLUSIONS: Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood.
Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

The Journal of nutrition　2025/03/07

DOI： 10.1016/j.tjnut.2025.02.024 　

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BACKGROUND: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied. OBJECTIVE: To explore breast milk HMO compositions and molecules associated with AR status in children. METHODS: In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor). RESULTS: In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051). CONCLUSIONS: Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).
Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. International-journal Peer-reviewed

Chikana Kawaguchi, Mami Ishikuro, Ryota Saito, Keiko Murakami, Aoi Noda, Genki Shinoda, Misato Aizawa, Hisashi Ohseto, Noriyuki Iwama, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

The Journal of clinical endocrinology and metabolism　2025/01/20

DOI： 10.1210/clinem/dgae825 　

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BACKGROUND: The association of maternal hyperglycemia with childhood developmental delay has been examined; however, only 2 studies used maternal blood glucose level as a continuous variable as an exposure. A present study aimed to investigate the influence of maternal fasting plasma glucose (mFPG) level in early gestation on developmental delay in children. METHODS: This cohort study included 1541 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. mFPG level before 24 gestational weeks was obtained as a continuous and categorical variable. Developmental delay in 2-year-old children was assessed by mothers using the Ages and Stages Questionnaire (third edition). Associations between mFPG level and developmental delay in children were evaluated using multiple logistic regression analyses. RESULTS: The prevalence of mFPG level ≥95 mg/dL was 5.2%. At 2 years old, 15.1% of the children had developmental delays. mFPG level as a continuous variable was not associated with an increased risk of developmental delay across the 5 domains in children [adjusted odds ratio (aOR), 95% confidence interval (CI): 1.004, 0.990-1.018]. mFPG level ≤70 mg/dL was associated with developmental delay across 5 domains (aOR, 95% CI: 0.464, 0.229-0.943) in children than that with a mFPG level 71 to 94 mg/dL. No association was found between mFPG level ≤70 mg/dL and ≥95 mg/dL and developmental delay in any domains among children. CONCLUSION: mFPG level in early gestation was not associated with an increased risk of any developmental delays in 2-year-old children.
Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Peer-reviewed

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Circulation journal : official journal of the Japanese Circulation Society　2025/01/11

DOI： 10.1253/circj.CJ-24-0780 　

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BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.
Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study. International-journal Peer-reviewed

Satoko Suzuki, Ryutaro Arita, Taku Obara, Tomofumi Ishikawa, Tadaharu Kunitoki, Takamasa Sakai, Aoi Noda, Genki Shinoda, Mami Ishikuro, Masatsugu Orui, Shinichi Kuriyama, Minoru Ohsawa, Ken Haneda, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

Frontiers in pharmacology　16　1562724-1562724　2025

DOI： 10.3389/fphar.2025.1562724 　

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INTRODUCTION: Traditional Japanese (Kampo) medicine containing Prunus persica kernel (KPK) is prescribed for treating menstrual- and pregnancy-related symptoms. However, no safety information is available regarding its use in pregnant women. In this study, we examined the associations of KPK prescriptions during the first trimester of pregnancy with preterm births and major congenital malformations (MCMs) in newborns. METHODS: From a large-scale Japanese health insurance claims database, we included pregnant women enrolled with the same healthcare insurer from 3 months before pregnancy to the date of delivery, who gave birth between 2010 and 2019, and whose data were linked to their infants. We then selected pregnant women who were prescribed KPK during the first trimester as the exposure group, and those who were prescribed tokishakuyakusan (TSS), commonly used for pregnancy-related symptoms, during the same period as controls. The association between KPK prescriptions and preterm birth or MCM among infants was examined using a multivariate logistic regression analysis. RESULTS: Of the 75,398 infants, TSS and KPK was prescribed to 2,548 (3.38%) and 283 (0.38%) women during the first trimester, respectively. In the TSS group, 311 of 2,491 infants (12.5%) experienced preterm births, whereas 40 of 283 infants (14.1%) in the KPK group experienced preterm births. The risk of preterm birth in the KPK group was not significantly different from that in the TSS group (adjusted risk ratio, 1.122; 95% confidence interval, 0.827-1.521). In the TSS group, 157 of 2,491 infants (6.3%) had MCMs, whereas 15 of 283 infants (5.3%) in the KPK group had MCMs. There was no significant difference in the incidence of MCM in the first year after birth between infants in the KPK and TSS groups (adjusted odds ratio, 0.820; 95% confidence interval, 0.475-1.415). CONCLUSION: There was no significant difference in the risk of preterm birth or MCMs between pregnant women prescribed KPK and those prescribed TSS during the first trimester.
Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. International-journal Peer-reviewed

Nobuo Fuse, Hayato Anzawa, Miyuki Sakurai, Ikuko N Motoike, Satoshi Nagaie, Tomohiro Nakamura, Akiko Miyazawa, Eiichi N Kodama, Masatsugu Orui, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Makiko Taira, Ritsuko Shimizu, Naoki Nakaya, Mami Ishikuro, Taku Obara, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Kazuki Kumada, Shinichi Kuriyama, Atsushi Hozawa, Yoko Izumi, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology science　5　(5)　100821-100821　2025

DOI： 10.1016/j.xops.2025.100821 　

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PURPOSE: This study was conducted to elucidate the distribution and determinants of ocular biometric parameters and to assess the association between intraocular pressure (IOP) and single nucleotide polymorphisms (SNPs) in the Japanese population-based genome cohort studies. DESIGN: Cross-sectional analysis involving genome-wide association studies (GWASs). PARTICIPANTS: In total, 22 150 participants aged >18 years from the population cohort (Community-Based Cohort [CommCohort]) and 11 302 participants from the Birth and Three-Generation (BirThree) Cohort of the Tohoku Medical Megabank Organization Eye Study were examined. METHODS: Participant underwent interviews, ophthalmic and physiological examinations, laboratory tests, and microarray analyses. Genome-wide association studies were conducted in the CommCohort (discovery stage) and the BirThree Cohort (replication stage), followed by a meta-analysis. Associations of SNPs and IOP were evaluated using a genome-wide significance threshold (5 × 10- 8). MAIN OUTCOME MEASURES: Association of SNPs with IOP and distributions of IOP by sex and age. RESULTS: In the discovery stage, the mean IOP of the right and left eye was 13.95 and 14.02 mmHg, respectively. In the replication stage, the corresponding values were 14.32 and 14.27 mmHg, respectively. A significant age-related reduction in IOP was observed in both stages (P < 0.001). Genome-wide association studies identified 573 and 2 genome-wide significant SNPs in the discovery and replication stages, respectively. Meta-analysis revealed 1601 significant SNPs across 21 loci on 11 chromosomes (Chrs). Of these loci, 17 were previously known to be associated with IOP or glaucoma, while four-septin-8 (SEPT8; Chr5), aldehyde dehydrogenase 2 (ALDH2; Chr12), collagen type VI alpha 2 chain (COL6A2; Chr21), and Wnt family member 7B (WNT7B; Chr22)-were newly identified. CONCLUSIONS: This large-scale GWAS in a Japanese population identified 21 loci associated with IOP, including 4 novel loci. The findings highlight both genetic similarities and population-specific variations in SNPs influencing IOP and provide valuable insights to enhance eye health care, including glaucoma management. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. International-journal Peer-reviewed

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

BMJ public health　3　(1)　e001746　2025/01

DOI： 10.1136/bmjph-2024-001746 　

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OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.
Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

DOI： 10.1002/pcn5.70025 　

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AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Chikana Kawaguchi, Maki Ozawa, Takanori Hidaka, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Masatsugu Orui, Taku Obara, Yumiko Ito, Takashi Kakinuma, Kazuhiro Kudoh, Hiroaki Ozawa, Satoshi Nakagawa, Masato Mizuashi, Ryoko Omori, Masatoshi Deguchi, Yumi Kanbayashi, Masayuki Asano, Toshiya Takahashi, Muneo Tanita, Masahiro Hara, Kenshi Yamasaki, Takayoshi Tadaki, Hiromi Suzuki, Katsuko Kikuchi, Kenichiro Tsuchiyama, Takenobu Ohashi, Shu Sasai, Motoko Honda, Taku Fujimura, Sadanori Furudate, Yoshiko Kagimoto, Maki Kawamura, Nobuko Tabata, Rika Chikama, Hiromi Komatsu, Yota Sato, Kayo Tanita, Yutaka Kimura, Shino Yusa, Hitoshi Terui, Hisayuki Tono, Yusuke Muto, Shinichi Kuriyama, Masayuki Yamamoto, Setsuya Aiba

Allergology international : official journal of the Japanese Society of Allergology　2024/10/18

DOI： 10.1016/j.alit.2024.09.008 　

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BACKGROUND: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey. METHODS: This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists' diagnoses. RESULTS: Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75-0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively. CONCLUSIONS: Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.
The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Aoi Noda, Ryutaro Arita, Taku Obara, Satoko Suzuki, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Fumiko Matsuzaki, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Shinichi Kuriyama

Pharmacoepidemiology and drug safety　33　(10)　e70033　2024/10

DOI： 10.1002/pds.70033 　

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PURPOSE: Japanese traditional (Kampo) medicines are often used for pregnant women in Japan. However, no comprehensive studies have been conducted regarding the self-reported use of these medicines during pregnancy. This study investigated the use of Kampo medicines during pregnancy in Japan using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (July 2013 to March 2017) at approximately 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed Kampo medicines use over three periods: (1) 12 months before pregnancy diagnosis, (2) the period between pregnancy diagnosis and around Week 12 of pregnancy and (3) from around Week 12 of pregnancy. RESULTS: In total, 19 220 women were included in the analysis. The proportions using prescribed Kampo medicines were 4.1% before pregnancy diagnosis, 4.5% from diagnosis to Week 12% and 4.5% after Week 12 of pregnancy. The most frequently prescribed Kampo medicines were tokishakuyakusan (1.0%) before pregnancy diagnosis, shoseiryuto (1.3%) from diagnosis to Week 12 and shoseiryuto (1.5%) Post-week 12. Sixty of the pregnant women used Kampo medicines containing crude drugs, which should be administered cautiously during pregnancy. CONCLUSION: The proportion of Kampo medicines use before and during pregnancy was 4%-5%. Some pregnant women used Kampo medicines containing crude drugs that should be administered cautiously during pregnancy. Further research is required to determine the safety of Kampo medicines during pregnancy.
Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population. International-journal Peer-reviewed

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Biobank Japan Project Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Rheumatology (Oxford, England)　2024/09/13

DOI： 10.1093/rheumatology/keae492 　

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OBJECTIVE: To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. METHODS: This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. RESULTS: Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61-12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736-0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751-0.819 for lifestyle and PRS; p = 0.07). CONCLUSION: : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. International-journal Peer-reviewed

Ippei Takahashi, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Fuji Nagami, Atsushi Hozawa, Tomoko Nishimura, Kenji J Tsuchiya, Shinichi Kuriyama

Journal of public health (Oxford, England)　2024/09/11

DOI： 10.1093/pubmed/fdae240 　

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BACKGROUND: We aim to discover which, if any, of the subscales of internalizing and externalizing behavioral problems at age 3 are still associated with screen time (ST) at age 2 after adjusting for behavioral problems scores at age 2. METHODS: This study was conducted under the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Information was gathered prospectively, with 7207 mother-child pairs included in the analysis. Children's ST was categorized in hours a day at age 2 (<1, 1-<2, 2-<4, ≥4). We assessed children's behavioral problems using the Child Behavior Checklist for Ages 1½-5 (CBCL) at ages 2 and 3. 'Having behavioral problems' was defined by them being within a clinical range for internalizing behaviors (withdrawn, somatic complaints, anxious/depressed and emotionally reactive) and externalizing behaviors (attention problems and aggressive behaviors) at age 3. Continuous scores on each of the behavioral problem scales at age 2 were used as covariates. RESULTS: Greater ST for children at age 2 was associated with specific subscales for emotionally reactive and aggressive behaviors at age 3. CONCLUSIONS: This study found that ST is prospectively associated with some behavioral scales but not others.
Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Ippei Takahashi, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Ryo Obara, Aoi Noda, Minoru Ohsawa, Tomofumi Ishikawa, Nariyasu Mano, Hidekazu Nishigori, Fumihiko Ueno, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(3)　e226　2024/09

DOI： 10.1002/pcn5.226 　

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AIM: To examine the association of the combination of taking neuropsychiatric medications from the onset of pregnancy to mid-pregnancy and maternal psychological distress at mid-pregnancy, with children's behavioral problems. METHODS: Neuropsychiatric medication use from the onset of pregnancy to mid-pregnancy was defined by the self-reported name of the neuropsychiatric medication in the questionnaire in early and mid-pregnancy. Maternal psychological distress was defined by the Kessler Psychological Distress Scale (K6) ≥13 on the questionnaire in mid-pregnancy. We classified the participants into four categories based on the combination of taking neuropsychiatric medications and psychological distress: "None," "Medications only," "K6 ≥ 13 only," and "Both." Children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at 2 years of age. The clinical ranges of the internalizing and externalizing scales of the CBCL were defined as behavioral problems. We conducted a multivariable logistic regression analysis to examine the associations between the four categories of maternal exposure and children's behavioral problems. RESULTS: Compared with the "None" category (n = 9873), the "K6 ≥ 13 only" category (n = 308) was statistically significantly associated with internalizing and externalizing problems. In contrast, the "Medications only" (n = 93) and "Both" (n = 22) categories were not statistically significantly associated with internalizing and externalizing problems, although the point estimates of the odds ratio in the "Both" category were relatively high (1.58 for the internalizing problem and 2.50 for the externalizing problem). CONCLUSION: The category of mothers taking neuropsychiatric medications and having no psychological distress during pregnancy was not associated with children's behavioral problems in the present population.
The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. International-journal Peer-reviewed

Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　2024/08/08

DOI： 10.1038/s41440-024-01827-z 　

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This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.
Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. International-journal Peer-reviewed

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2024/07/10

DOI： 10.1038/s41440-024-01790-9 　

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Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.
Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. International-journal Peer-reviewed

Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Scientific reports　14　(1)　15681-15681　2024/07/08

DOI： 10.1038/s41598-024-66180-0 　

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Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study Peer-reviewed

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

JMA Journal　7　(3)　353-363　2024/07
Publisher: Japan Medical Association
DOI： 10.31662/jmaj.2024-0043 　

ISSN： 2433-328X

eISSN： 2433-3298
Associations of combined genetic and lifestyle risks with hypertension and home hypertension. International-journal Peer-reviewed

Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Hypertension research : official journal of the Japanese Society of Hypertension　2024/06/24

DOI： 10.1038/s41440-024-01705-8 　

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No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Peer-reviewed

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2024/06/22

DOI： 10.5551/jat.64906 　

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AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
A fine-scale genetic map of the Japanese population. International-journal Peer-reviewed

Jun Takayama, Satoshi Makino, Takamitsu Funayama, Masao Ueki, Akira Narita, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Masayuki Yamamoto, Gen Tamiya

Clinical genetics　2024/05/08

DOI： 10.1111/cge.14536 　

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Genetic maps are fundamental resources for linkage and association studies. A fine-scale genetic map can be constructed by inferring historical recombination events from the genome-wide structure of linkage disequilibrium-a non-random association of alleles among loci-by using population-scale sequencing data. We constructed a fine-scale genetic map and identified recombination hotspots from 10 092 551 bi-allelic high-quality autosomal markers segregating among 150 unrelated Japanese individuals whose genotypes were determined by high-coverage (30×) whole-genome sequencing, and the genotype quality was carefully controlled by using their parents' and offspring's genotypes. The pedigree information was also utilized for haplotype phasing. The resulting genome-wide recombination rate profiles were concordant with those of the worldwide population on a broad scale, and the resolution was much improved. We identified 9487 recombination hotspots and confirmed the enrichment of previously known motifs in the hotspots. Moreover, we demonstrated that the Japanese genetic map improved the haplotype phasing and genotype imputation accuracy for the Japanese population. The construction of a population-specific genetic map will help make genetics research more accurate.
Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, Fumiko Matsuzaki, Rieko Hatanaka, Ryo Obara, Kei Morishita, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Shinichi Kuriyama

European journal of clinical pharmacology　2024/04/17

DOI： 10.1007/s00228-024-03685-7 　

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PURPOSE: To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods: (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy. RESULTS: In total, 19,297 women were included in the analysis. The proportion of pregnant women using medications was 49.0% prior to pregnancy diagnosis, 52.1% from diagnosis to week 12, and 58.4% post week 12 of pregnancy. The most frequently prescribed medications were loxoprofen sodium hydrate (5.5%) prior to pregnancy diagnosis, magnesium oxide (5.9%) from diagnosis to week 12, and ritodrine hydrochloride (10.5%) post week 12 of pregnancy. The number of women who used suspected teratogenic medications during early pregnancy was 96 prior to pregnancy diagnosis, 48 from diagnosis to week 12, and 54 post week 12 of pregnancy. CONCLUSION: We found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance.
Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Geng Chen, Mami Ishikuro, Hisashi Ohseto, Keiko Murakami, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

Acta obstetricia et gynecologica Scandinavica　2024/03/07

DOI： 10.1111/aogs.14820 　

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INTRODUCTION: Developmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association. MATERIAL AND METHODS: We used data from 5934 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42 months of age, measured developmental delay in five areas. We performed multivariate quasi-Poisson regression and causal mediation analysis by neonatal outcomes. RESULTS: At 24 months of age, compared to offspring born from normotensive mothers, offspring born from HDP-affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09-1.52) in the areas of communication (RR 1.21, 95% CI: 1.00-1.45) and personal-social (RR 1.15, 95% CI: 1.03-1.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42 months of age. CONCLUSIONS: Exposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.
Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. International-journal Peer-reviewed

Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

BMC public health　24　(1)　714-714　2024/03/05

DOI： 10.1186/s12889-024-18244-z 　

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BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.
Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2024/02/06

DOI： 10.5551/jat.64535 　

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AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.
Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. International-journal Peer-reviewed

Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

Drugs - real world outcomes　2024/01/19

DOI： 10.1007/s40801-023-00411-0 　

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BACKGROUND: Japanese traditional (Kampo) medicines containing ephedra may be used to treat colds during pregnancy. There are reports that ephedrine, a component of ephedra, has a risk of teratogenicity; however, the evidence remains equivocal. OBJECTIVE: This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with exposure to Kampo medicines containing ephedra during the first trimester of pregnancy using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: To 23,730 mother-infant pairs who participated in the TMM BirThree Cohort Study from July 2013 to March 2017, questionnaires in early and middle pregnancy were distributed approximately at weeks 12 and 26 of pregnancy, respectively. Infants' risk of MCMs in women who used Kampo medicines containing ephedra or acetaminophen during the first trimester was assessed, and the odds ratios (ORs) were estimated with unadjusted and adjusted analyses. RESULTS: Among 20,879 women, acetaminophen and Kampo medicines containing ephedra were used in 665 (3.19%) and 376 (1.80%) women, respectively, in the first trimester. Among the infants born to the mothers who used acetaminophen or Kampo medicine containing ephedra during the first trimester, 11 (1.65%) and 8 (2.13%), respectively, had overall MCMs. OR of overall MCMs was higher in women who used Kampo medicines containing ephedra than in those who used acetaminophen in the first trimester (adjusted OR, 1.45; 95% confidence interval (CIs), 0.57-3.71); however, the difference was not statistically significant. CONCLUSIONS: In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.
Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study Peer-reviewed

Takase, M., Nakaya, N., Tanno, K., Kogure, M., Hatanaka, R., Nakaya, K., Chiba, I., Kanno, I., Nochioka, K., Tsuchiya, N., Nakamura, T., Hirata, T., Obara, T., Ishikuro, M., Kotozaki, Y., Uruno, A., Kobayashi, T., Kodama, E.N., Hamanaka, Y., Orui, M., Ogishima, S., Nagaie, S., Ohmomo, H., Fuse, N., Sugawara, J., Shimizu, A., Izumi, Y., Kuriyama, S., Hozawa, A.

Hypertension Research　47　(6)　2024

DOI： 10.1038/s41440-024-01582-1 　

ISSN： 1348-4214 0916-9636
Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama

Nutrition journal　22　(1)　66-66　2023/12/06

DOI： 10.1186/s12937-023-00901-5 　

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BACKGROUND: Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5-6, 3-4, and 0-2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years. RESULTS: The proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0-2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02-1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0-2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32-2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0-2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81-1.39 and OR 1.15 (95% CI 0.84-1.57), respectively. CONCLUSION: For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. International-journal Peer-reviewed

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2023/10/31

DOI： 10.1038/s41440-023-01484-8 　

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Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2023/10/06

DOI： 10.5551/jat.64425 　

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AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.
Establishment of Training System to Cope with Mental Health and Social Issues in Disaster Recovery Public Housing After the Great East Japan Earthquake Peer-reviewed

Masatsugu Orui

Journal of Disaster Research　18　(5)　485-491　2023/08/01
Publisher: Fuji Technology Press Ltd.
DOI： 10.20965/jdr.2023.p0485 　

ISSN： 1881-2473

eISSN： 1883-8030
Disaster and Suicide Prevention Activities: A Literature Review Focused on Suicide-Related Outcomes Peer-reviewed

Masatsugu Orui

Journal of Suicidology　18　(2)　518-528　2023/06/30

DOI： 10.30126/JoS.202306_18(2).0004 　
The Impact of the COVID-19 Pandemic on Suicide Rate Trends in the Tsunami-Disaster-Affected Area Following the Great East Japan Earthquake: A Descriptive Study Peer-reviewed

Orui, M., Saeki, S., Kozakai, Y., Harada, S., Hayashi, M.

Crisis　44　(2)　2023

DOI： 10.1027/0227-5910/a000832 　

ISSN： 2151-2396 0227-5910
東日本大震災の被災地での継続的な被災者支援にむけた次代の職員への継承の取り組み Peer-reviewed

大類真嗣, 佐伯涼香, 下村瑞希, 細川護之, 原田修一郎, 林みづ穂

最新精神医学　27　(5)　359-368　2022/09
Publisher: (株)世論時報社
ISSN： 1342-4300
自死予防に関する相談電話の相談対応者向け支援ツールの開発の実践報告 Peer-reviewed

大類真嗣, 田中充

自殺予防と危機介入　42　(2)　41-48　2022/09
Publisher: (一社)日本自殺予防学会
ISSN： 1883-6046

eISSN： 2436-8369
Suicide and Suicide Prevention Activities Following the Great East Japan Earthquake 2011: A Literature Review. International-journal Peer-reviewed

Masatsugu Orui

International journal of environmental research and public health　19　(17)　2022/09/01

DOI： 10.3390/ijerph191710906 　

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BACKGROUND: Since the Great East Japan Earthquake (GEJE), numerous studies have been conducted, but no comprehensive review study has been carried out. Thus, this literature review aimed to examine how the GEJE might affect suicide and suicidal behaviors from a long-term perspective. METHODS: For the literature review, a search of electronic databases was carried out to find articles written in English and in Japanese that were related to suicide and its risk factors, as well as suicide prevention activities following the GEJE. Thirty-two articles were then selected for the review. RESULTS: There were several findings, as follows: (1) gender differences in suicide rates in the affected area: nationwide, the suicide rates in men showed a delayed increase, whereas suicide rates in women increased temporarily immediately after the GEJE; (2) the suicide rates increased again in the recovery phase; (3) the background of the suicides was linked to both disaster-related experiences, and indirect reasons pertaining to the GEJE; and (4) intensive intervention combined with a high-risk and community-focused approach could prevent suicides following the disaster. CONCLUSIONS: Although further accumulation of knowledge about suicide and suicide prevention is essential, these findings can contribute to response, recovery, and preparedness in relation to future disasters.
Posttraumatic Growth after the Fukushima Nuclear Disaster: Examination of Free Descriptions among Fukushima Residents Who Lived in the Evacuation Area. International-journal Peer-reviewed

Hajime Iwasa, Chihiro Nakayama, Nobuaki Moriyama, Masatsugu Orui, Seiji Yasumura

International journal of environmental research and public health　19　(1)　2021/12/24

DOI： 10.3390/ijerph19010192 　

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We examined the differences in the posttraumatic growth (PTG) free descriptions from clusters of Fukushima residents (evacuation and non-evacuation zones) who experienced the Great East Japan Earthquake, and the relationship between "recovery from radiation anxiety" and the PTG-free description classification in these regions. A mail survey was conducted in August 2016 among Fukushima residents aged 20-79 years for free descriptions of their PTG. Participants were then divided into the "no anxiety," "recovered from anxiety," and "unrecovered from anxiety" groups based on their "recovery from radiation anxiety." Data from 786 responses were analyzed. The PTG-free descriptions were classified into eight categories. Among those who lived in the evacuation zone versus those in the non-evacuation zone, "relating to others" (non-evacuation zone: 11.9% vs. evacuation zone: 18.4%) and "appreciation of life" (non-evacuation zone: 2.7% vs. evacuation zone: 9.8%) were significantly higher, and "increased awareness of disaster prevention" (non-evacuation zone: 20.4% vs. evacuation zone: 8.0%) was significantly lower. In the evacuation zone, "renewed recognition of nuclear issues" was significantly lower than the expected value in the no anxiety group (3.1%) and significantly higher than the expected value in the recovered group (22.9%). Further studies are needed to build support measures and potentially aid in preparing for future disasters.
Those Who Have Continuing Radiation Anxiety Show High Psychological Distress in Cases of High Post-Traumatic Stress: The Fukushima Nuclear Disaster. International-journal Peer-reviewed

Orui M, Nakayama C, Moriyama N, Tsubokura M, Watanabe K, Nakayama T, Sugita M, Yasumura S

International journal of environmental research and public health　18　(22)　2021/11/17

DOI： 10.3390/ijerph182212048 　

ISSN： 1661-7827

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Background: this cross-sectional study aimed to clarify the associations among media utilization, lifestyles, and the strong radiation anxiety that has persisted 9 years after the 2011 nuclear accident. Moreover, the relationships among psychological distress, post-traumatic stress, and strong radiation anxiety were examined. Methods: for the multivariate regression analysis, the independent variables were radiation anxiety at the time of the accident and the current status, categorized as “continuing/emerging strong radiation anxiety”. Media utilization (local, national, internet, and public broadcasts, and public relations information) and lifestyle variables (sleep quality, regular exercise, and drinking habits) were set as the dependent variables. Moreover, the psychological distress of residents with continuing/emerging strong radiation anxiety was examined by an analysis of covariance stratified by post-traumatic stress. Result: there was no significant association between lifestyle variables and media utilization, except for local media (OR: 0.435, 95% CI: 0.21–0.90). Conversely, significantly high psychological distress was confirmed among residents with continuing/emerging radiation anxiety. The K6 score, representing psychological distress, for those with higher post-traumatic stress was 12.63; for those with lower post-traumatic stress, it was 5.13 (p = 0.004). Conclusions: residents with continuing/emerging strong radiation anxiety showed high psychological distress, which has been strengthened by higher post-traumatic stress.
Practical report of disaster-related mental health interventions following the great East Japan earthquake during the COVID-19 pandemic: Potential for suicide prevention Peer-reviewed

Orui, M., Saeki, S., Harada, S., Hayashi, M.

International Journal of Environmental Research and Public Health　18　(19)　2021/10/03

DOI： 10.3390/ijerph181910424 　

ISSN： 1660-4601 1661-7827
【その後の自殺対策I-社会的な自殺問題と対策の現在-】災害と自殺対策 Invited

大類真嗣

精神科治療学　36　(8)　933-938　2021/08
Publisher: (株)星和書店
ISSN： 0912-1862

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東日本大震災後、生活再建が進まない被災者が取り残される、いわゆるはさみ状格差や仮設住宅の供与終了などが影響し、被災地の自殺死亡率が上昇した。被災地での自殺対策は、被災者のこころのケアを通じた、「精神的不調に関するスクリーニングおよびアウトリーチを基本とする継続的な支援」「災害弱者に対する孤立防止のためのコミュニティ形成」「生活、就労、金銭面、法的な課題に対応するための多機関連携」など、精神保健福祉上、社会生活上の課題に対して両側面の視点で支援を行い、さらに被災者を取り巻くコミュニティが良好に形成される取り組みを展開する必要がある。加えて、エビデンスに基づいた自殺対策の展開のためにも、被災地の自殺死亡率のモニタリングも並行することを念頭に置きたい。(著者抄録)
Trends in Suicide Mortality in 10 Years around the Great East Japan Earthquake: Analysis of Evacuation and Non-Evacuation Areas in Fukushima Prefecture Peer-reviewed

Yujiro Kuroda, Masatsugu Orui, Arinobu Hori

International Journal of Environmental Research and Public Health　18　(11)　6005-6005　2021/06/03
Publisher: MDPI AG
DOI： 10.3390/ijerph18116005 　

eISSN： 1660-4601

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This study analyzed the suicide mortality rate in 12 municipalities in Fukushima Prefecture designated as evacuation areas following the 2011 nuclear disaster. Changes in suicide rates were examined using an exponential smoothing time series model. In the evacuation areas, the suicide rate of men increased immediately after the disaster and then decreased from 47.8 to 23.1 per 100,000 during about 1½ years after the disaster. However, with the lifting of the evacuation order, it again exceeded that of non-evacuation areas and continued to do so for the next 3 years. On the other hand, the suicide rate in women in the evacuation areas increased later than that in men. These results indicate the need for continuous support following the lifting of the evacuation order. In addition, it is necessary to enhance social networks, which continue to confer protection, because of the isolation of the elderly as highlighted in our previous study.
The ongoing activities of livelihood support counselors following nuclear disaster under the COVID-19 restrictions: A preliminary survey Peer-reviewed

Orui, M., Fukasawa, M., Horikoshi, N., Suzuki, Y., Kawakami, N.

Public Health in Practice　2　2021/03/19

DOI： 10.1016/j.puhip.2021.100107 　

ISSN： 2666-5352
原子力災害下における福島県住民の心的外傷後成長の実態：自由記述の検討 Peer-reviewed

岩佐一, 中山千尋, 森山信彰, 大類真嗣, 安村誠司

日本公衆衛生雑誌　69　(2)　158-168　2021
Publisher: 日本公衆衛生学会
DOI： 10.11236/jph.21-064 　

ISSN： 0546-1766

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目的「心的外傷後成長（posttraumatic growth）」（以下，PTG）は，「危機的な出来事や困難な経験との精神的なもがきや奮闘の結果生じるポジティブな心理的変容」であり，心的外傷の体験者に対する心理的支援に活用されている。本研究は，東日本大震災を経験した福島県住民におけるPTGの自由記述を分類し，その傾向を調べること，基本属性とPTG自由記述の関連，「放射線健康影響不安からの回復」とPTG自由記述の関連について検討することを目的とした。方法 2016年8月に，20～79歳の福島県住民2,000人に自記式郵送調査を行った。PTGの有無について質問した後，PTGの自由記述を求めた。基本属性として，年齢，性別，教育歴の回答を求めた。震災直後と調査時点における，放射線健康影響に対する不安を問い，対象者を「不安なし」群，「不安から回復」群，「不安継続」群に分割した。Posttraumatic Growth Inventory（Tedeschi & Calhoun, 1996）における5つの領域（「他者との関係」「新たな可能性」「人間としての強さ」「精神性的変容」「人生への感謝」）に基づき，さらに西野ら（2013）を参考として，「防災意識の高揚」「原子力問題への再認識」「権威からの情報に対する批判的吟味」を加えた8つのカテゴリにPTG自由記述を分類した。結果 916人から回答を得て，欠損の無い786人を分析対象とした。女性と64歳以下の者では，「他者との関係」「人生への感謝」を回答した者が多かった。教育歴が高い者では，「他者との関係」「原子力問題への再認識」「権威からの情報に対する批判的吟味」「人間としての強さ」「精神性的変容」「人生への感謝」を回答した者が多かった。「不安から回復」群において，「原子力問題への再認識」を回答した者が多かった。結論女性や若年者では，家族・友人関係，地域との結びつきを実感する等の報告や，日常生活に対する感謝の念が生じる等の報告がなされやすかった。教育歴が高い者では，国や電力会社，全国紙等が発する情報を鵜呑みにせず批判的に吟味するようになった等の報告や，震災後自身の精神的な強さや成長を認識できた等の報告がなされやすかった。放射線健康影響不安から回復した者では，原発やエネルギー問題に対して新たな認識が生じた等の報告がなされやすかった。
Current Psychological Distress, Post-traumatic Stress, and Radiation Health Anxiety Remain High for Those Who Have Rebuilt Permanent Homes Following the Fukushima Nuclear Disaster. International-journal Peer-reviewed

Orui M, Nakayama C, Moriyama N, Tsubokura M, Watanabe K, Nakayama T, Sugita M, Yasumura S

International journal of environmental research and public health　17　(24)　1-14　2020/12/19

DOI： 10.3390/ijerph17249532 　

ISSN： 1661-7827

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Objective: The Fukushima Daiichi nuclear disaster in 2011 produced psychological reactions among evacuees. Despite the harsh situation, subsequently, there has been gradual progress in reconstruction, with more than half of the evacuees returning after the evacuation. Our hypothesis is that evacuee mental health will now be better due to new stable living conditions. This study aims to clarify the statuses of psychological distress, post-traumatic stress, and radiation health anxiety among evacuees who have rebuilt permanent homes after evacuation. Methods: A cross-sectional questionnaire survey of 1600 residents was conducted in 2020. As primary outcomes, the survey measured psychological distress (Kessler 6), post-traumatic stress (post-traumatic stress four-item checklist), and radiation health anxiety. The data are compared for residents who have rebuilt permanent home and those who did not evacuate. Results: In the co-variant analysis, the statuses of psychological distress (p < 0.001), post-traumatic stress (p < 0.001), and radiation health anxiety (p < 0.001) are found to still be high, with significant differences when compared to those who did not evacuate. These results are still at an equivalent level for the continuing evacuation. Conclusion: Our findings may indicate a necessity for continuing disaster-related mental health activities even though the living conditions have improved.
Associated factors related to participation in general health checkup and survey of the effect of low-dose radiation exposure on health of residents of Fukushima Prefecture after the Fukushima Daiichi nuclear power plant accident. International-journal Peer-reviewed

Moriyama N, Nakayama C, Orui M, Kuroda Y, Iwasa H, Horiuchi T, Nakayama T, Sugita M, Yasumura S

Preventive medicine reports　20　101214-101214　2020/12

DOI： 10.1016/j.pmedr.2020.101214 　

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© 2020 The Author(s) The Fukushima Daiichi nuclear power plant accident caused radioactive contamination of the surrounding area. In addition to annual health checkups, a survey of the effects of low-dose radiation exposure on health among Fukushima Prefecture residents after the accident has been conducted. Despite health literacy (HL) being recognized as essential to health, its association with participation in these checkups and the survey remains unknown. We aimed to describe the HL status of the Fukushima Prefecture residents and to verify the hypothesis that HL is associated with participation in both checkup and survey. In a cross-sectional study, a questionnaire was sent to 2000 randomly sampled Fukushima Prefecture residents; data from 770 individuals were analyzed. Communicative and critical HL were measured using a 5-point scale. Factors associated with participation were examined using logistic regression. The survey's valid response rate was 38.5%. The average HL score was 3.11 ± 0.81. HL was not associated with checkup or survey participation. Checkup participation was negatively associated with radiation anxiety (odds ratio 0.93, 95% confidence interval 0.86–0.99, p = 0.03). The HL of Fukushima Prefecture residents after the accident was relatively lower than that of the Japanese general population, which may be attributed to difference in educational background. The complexities involved in understanding the effects of radiation on the health of residents could explain why no association between HL and participation in a health checkup and survey was observed. Future studies with a longitudinal design should clarify causality between anxiety and checkup participation.
福島第一原子力発電所事故による避難指示解除後の精神障がい者のサービス利用状況 Peer-reviewed

大類真嗣, 前田正治, 安村誠司

最新精神医学　25　(5)　425-431　2020/09
Publisher: (株)世論時報社
ISSN： 1342-4300

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目的・方法:福島第一原子力発電所事故による避難を余儀なくされたA自治体内の8名の当事者を対象に、避難指示が解除された1年後の2018年3〜5月に面接調査を実施し、精神保健福祉手帳保持者の精神保健福祉サービスの利用状況を把握し、今後必要とされる体制を検討した。結果:震災前後の生活機能(GAF尺度)の変化は、悪化2名、改善1名であり、5名は変化なく、通院状況も避難中も継続されていた。避難生活中のサービス利用者(デイケア、グループホーム、就労継続支援事業所等)は4名だったが、調査時点まで継続利用者は1名のみであった。また、支援体制としては、"帰還後の日中の活動拠点の整備""アウトリーチ"の必要性があげられた。結論:通院状況、生活機能の顕著な変化はなかったが、継続的なサービス利用には少なからず影響があった。帰還した当事者の活動拠点の整備や、状態確認・支援のためのアウトリーチの必要性が求められる。(著者抄録)
東日本大震災後8年間の宮城県沿岸部の自殺死亡率の動向 Peer-reviewed

大類真嗣, 原田修一郎, 佐伯涼香, 佐藤喬二, 小堺幸, 林みづ穂

精神神経学雑誌　122　(8)　573-584　2020/08
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658

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大規模災害後,被災体験や避難による生活環境の変化などさまざまな精神的ストレスが増大し,被災地の自殺死亡率が一定期間上昇することが報告された.一方,復興期でも,新たな恒久的な生活拠点への転居に伴うコミュニティの再分離や,仮設住宅供与といった経済支援の終了などから自殺死亡率が上昇することが懸念される.今回,2011年に発生した東日本大震災による津波被害を受けた宮城県沿岸部を対象に,2016年5月の仮設住宅供与終了時期に着目した自殺死亡率の動向を,記述疫学研究により検討した.2009年3月から2019年2月までの警察庁自殺統計をもとに,宮城県内の沿岸市区町(仙台市宮城野区・若林区,石巻市,塩竈市,気仙沼市,名取市,多賀城市,岩沼市,東松島市,亘理町,山元町,七ヶ浜町,女川町,南三陸町)の12ヵ月移動平均を用いた月別自殺死亡率を把握した.月別自殺死亡率の動向は,震災後1〜2年経過した後に自殺死亡率が上昇した状況(人口10万人対16.1から22.0)と比較し,その上昇幅は小さいものの,2016年6月の15.6から2019年1月の17.9(人口10万人対)と徐々に上昇している傾向があった.性別では,男性では2016年6月付近から,また,女性では男性よりも1.5年ほど遅れて上昇した.今回の研究から直接的な原因は明らかにできないが,仮設住宅供与終了が開始された2016年5月以降,自殺死亡率がわずかではあるものの上昇していることから,供与終了に伴う経済的支援の終了やコミュニティの再分離の影響が示唆された.今回得られた知見は,将来発生しうる災害時でも,仮設住宅の供与終了など被災者を支援する制度の終了時期に自殺死亡率が上昇しうることを念頭におき,被災者への心理面に加え,経済面,就労面での支援を合わせて行うことや,地域住民同士の信頼関係や人間関係といったソーシャルキャピタルを醸成できる働きかけを継続し,強化していく必要性を示唆するものである.(著者抄録)
Development and evaluation of a gatekeeper training program regarding anxiety about radiation health effects following a nuclear power plant accident: A single-arm intervention pilot trial Peer-reviewed

Orui, M., Fukasawa, M., Horikoshi, N., Suzuki, Y., Kawakami, N.

International Journal of Environmental Research and Public Health　17　(12)　2020/06/26

DOI： 10.3390/ijerph17124594 　

ISSN： 1660-4601 1661-7827
The Association between Utilization of Media Information and Current Health Anxiety Among the Fukushima Daiichi Nuclear Disaster Evacuees Peer-reviewed

Masatsugu Orui, Chihiro Nakayama, Yujiro Kuroda, Nobuaki Moriyama, Hajime Iwasa, Teruko Horiuchi, Takeo Nakayama, Minoru Sugita, Seiji Yasumura

International Journal of Environmental Research and Public Health　17　(11)　3921-3921　2020/06/01
Publisher: MDPI AG
DOI： 10.3390/ijerph17113921 　

eISSN： 1660-4601

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The 2011 nuclear disaster in Fukushima was not only a health disaster, but also an information disaster. Although media can promote health communication following disasters, studies have revealed associations between media information and negative psychological reactions. To clarify the relationship between media utilization and current health anxiety due to radiation exposure, a cross-sectional questionnaire survey was conducted in Fukushima. We selected 2000 subjects from evacuation (i.e., 500) and non-evacuation (i.e., 1500) areas by two-stage stratified random sampling. As the independent variable, participants were asked about current health anxiety due to radiation exposure at the time of answering the questionnaire. For utilization of media about radiation exposure, local media, national media, Internet media, public broadcasts, and public relations information from local government were set as the dependent variables. Questionnaire data were analyzed by evacuation type (i.e., forced/voluntary). In a multivariate logistic regression analysis, the use of public relations information was significantly associated with lower anxiety for the forced evacuees (odds ratio: 0.72; 95% confidence interval: 0.56–0.93). Our findings highlight the importance of public relations information from local government in terms of it being associated with lower current health anxiety, and this could potentially aid in preparing for future disasters.
Re-Increased Male Suicide Rates in the Recovery Phase following the Great East Japan Earthquake: A 7-Year Follow-Up Study in Miyagi Prefecture Peer-reviewed

Orui, M.

Crisis　41　(6)　2020/03/06

DOI： 10.1027/0227-5910/a000656 　

ISSN： 2151-2396 0227-5910
災害時のメンタルヘルスと自殺予防

大類真嗣, 田中英三郎, 前田正治, 八木淳子, 近藤克則, 野村恭子, 伊藤弘人, 大平哲也, 井上彰臣, 堤明純

日本公衆衛生雑誌　67　(2)　101-110　2020/02
Publisher:
ISSN： 0546-1766

eISSN： 2187-8986
Resilience Factors Contributing to Mental Health Among People Affected by the Fukushima Disaster: Development of Fukushima Resilience Scale Peer-reviewed

Takebayashi, Y., Maeda, M., Orui, M., Nakajima, S., Momoi, M., Ito, A., Sato, H., Yasumura, S., Ohto, H.

Frontiers in Public Health　8　159　2020

DOI： 10.3389/fpubh.2020.00159 　

ISSN： 2296-2565
The association between effective workplace communication with superiors and lower psychological distress among workers in the evacuation area after the Fukushima Daiichi Nuclear Power Plant accident Peer-reviewed

Orui, M., Yasumura, S.

Journal of Occupational Health　61　(6)　471-480　2019/11
Publisher: (公社)日本産業衛生学会
DOI： 10.1002/1348-9585.12074 　

ISSN： 1348-9585 1341-9145
福島第一原子力発電所事故による避難指示解除後の自殺死亡率モニタリングと被災自治体と協働した自殺・メンタルヘルス対策の実践 Peer-reviewed

大類真嗣, 黒田佑次郎, 安村誠司

日本公衆衛生雑誌　66　(8)　407-416　2019/08
Publisher: 日本公衆衛生学会
ISSN： 0546-1766

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目的 2011年の福島第一原子力発電所事故による住民の精神的健康度の指標として、避難区域の自殺死亡率の動向を継続的に把握しており、2015年時点で避難指示が解除された市町村で上昇していることを確認した。そのため、1.2017年4月までに避難指示が解除された区域の自殺死亡率のモニタリングを行い、2.避難指示解除後に自殺死亡率の上昇の懸念のある福島県飯舘村を対象に、住民の自殺予防、精神的健康の向上を目的とした対策を展開した。方法 1.自殺死亡率のモニタリング:人口動態調査を基に、2017年4月までに大部分の地域で避難指示が解除された8市町村を対象に、自殺死亡率の推移を検討した。2.福島県飯舘村を対象とした避難指示解除後の自殺・メンタルヘルス対策:以下の3つの内容で対策を展開した。1)精神的健康度や自殺念慮に関するスクリーニングおよび個別支援、2)住民リーダーや支援者へのゲートキーパー養成講座を通じた地域づくり、3)被災自治体の職員への技術的支援(スクリーニングおよびハイリスク者支援、地域自殺対策計画策定に向けた住民の健康課題の抽出や事業整理および一般職員向け研修)。活動内容 1.避難指示解除区域の男性の自殺死亡率は低い状況から一転し、解除開始後の2015年から3年間全国よりも高い状況が続いた。女性では2013年以降全国水準よりも高く、とくに避難指示解除が進んだ2017年は全国よりも有意に高い状況であった。2.およそ4,800人の住民を対象に行ったスクリーニングでは、精神的健康度、ソーシャルサポート、1年以内の自殺念慮などを総合的に判断してハイリスク者を選別し、個別支援を行った。地域自殺対策計画策定に向けた住民の健康課題の抽出では「子ども家族との再同居で気を遣う」、「かつての仲間が村にはおらず孤独」など、仮設住宅からの転居の影響による、避難指示解除後に特徴的な課題が浮き彫りになった。その状況を踏まえ、様々な理由で精神的健康が損なわれている住民と接する機会の多い自治体一般職員向け自殺研修を開催した。結論避難指示解除区域の自殺死亡率のモニタリングや、コミュニティーの再分離といった避難指示解除後に特徴的な背景を踏まえ、地域づくりを意識したゲートキーパー養成、被災自治体の一般職員に対する研修を行った。解除後の自殺死亡率の上昇を踏まえ、当該地域での対策をより一層強化していく必要がある。(著者抄録)
Risk factors for problem drinking among evacuees in fukushima following the great east Japan earthquake: The fukushima health management survey Peer-reviewed

Ueda, Y., Murakami, M., Maeda, M., Yabe, H., Suzuki, Y., Orui, M., Yasumura, S., Ohira, T.

Tohoku Journal of Experimental Medicine　248　(4)　239-252　2019/08
Publisher: 東北ジャーナル刊行会
DOI： 10.1620/tjem.248.239 　

ISSN： 1349-3329 0040-8727
Recovery from radiation anxiety and posttraumatic growth among community dwellers after the nuclear disaster in Fukushima Peer-reviewed

Iwasa, H., Moriyama, N., Kuroda, Y., Nakayama, C., Orui, M., Horiuchi, T., Nakayama, T., Sugita, M., Yasumura, S.

Cogent Psychology　6　(1)　2019/04

DOI： 10.1080/23311908.2019.1602970 　

ISSN： 2331-1908
Efficacy of group intervention involving physical activity on subjective well-being of elderly returnees after evacuation following the Great East Japan Earthquake Peer-reviewed

Moriyama, N., Iwasa, H., Orui, M., Kuroda, Y., Ono, M., Okazaki, K., Takamura, M., Sato, N., Yasumura, S.

Psychogeriatrics　19　(3)　246-254　2019/03

DOI： 10.1111/psyg.12392 　

ISSN： 1479-8301 1346-3500
原子力発電所事故後の労働者の身体的健康度を保持する要因の検討 Peer-reviewed

西間木ます子, 大類真嗣, 安村誠司

福島県保健衛生雑誌　33　39-44　2019/03
Lingering health-related anxiety about radiation among Fukushima residents as correlated with media information following the accident at Fukushima Daiichi Nuclear Power Plant Peer-reviewed

Nakayama, C., Sato, O., Sugita, M., Nakayama, T., Kuroda, Y., Orui, M., Iwasa, H., Yasumura, S., Rudd, R.E.

PLoS ONE　14　(5)　e0217285　2019

DOI： 10.1371/journal.pone.0217285 　

ISSN： 1932-6203
Mental health recovery of evacuees and residents from the fukushima daiichi nuclear power plant accident after seven years—contribution of social network and a desirable lifestyle Peer-reviewed

Orui, M., Nakajima, S., Takebayashi, Y., Ito, A., Momoi, M., Maeda, M., Yasumura, S., Ohto, H.

International Journal of Environmental Research and Public Health　15　(11)　2018/10/27

DOI： 10.3390/ijerph15112381 　

ISSN： 1660-4601 1661-7827
Association between Health Literacy and Radiation Anxiety among Residents after a Nuclear Accident: Comparison between Evacuated and Non-Evacuated Areas. International-journal Peer-reviewed

Kuroda Y, Iwasa H, Orui M, Moriyama N, Nakayama C, Yasumura S

International journal of environmental research and public health　15　(7)　2018/07/11

DOI： 10.3390/ijerph15071463 　

ISSN： 1661-7827

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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Following the accident at the Fukushima Nuclear Power Plant in March 2011, both experts and the national government provided insufficient information on radiation, leading to widespread distrust in the community. This study aimed at clarifying the association between anxiety about radiation and health literacy among residents in evacuation and non-evacuation areas in Fukushima. A questionnaire survey was sent to randomly sampled residents between August and October 2016, and data from 777 responses (38.9% valid response) were analyzed. The questionnaire assessed current radiation anxiety and discrimination and prejudice based on radiation exposure through seven items and communicative and critical health literacy through five items. Multiple regression analysis of the association between radiation anxiety and health literacy showed that the level of health literacy was significantly negatively associated with radiation anxiety in the evacuation areas (marginally in the non-evacuation areas) and marginally negatively associated with discrimination and prejudice in the evacuation areas but not in the non-evacuation areas. Therefore, improving health literacy could alleviate radiation anxiety.
Risk Factor for Incident Functional Disability and the Effect of a Preventive Exercise Program: A 4-Year Prospective Cohort Study of Older Survivors from the Great East Japan Earthquake and Nuclear Disaster. International-journal Peer-reviewed

Kuroda Y, Iwasa H, Orui M, Moriyama N, Suemoto CK, Yashiro C, Matsuda K, Yasumura S

International journal of environmental research and public health　15　(7)　2018/07/06

DOI： 10.3390/ijerph15071430 　

ISSN： 1661-7827

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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Objective: The aim of this study is to assess the risk factors for incident functional disability among long-term evacuees of Iitate village after Great East Japan Earthquake and nuclear disaster (GEJE). We also investigated the effectiveness of exercise classes as an intervention measure in this situation. Methods: 1159 subjects (75.2 ± 5.8 years, 57.5% female) were included at baseline, and followed-up for four years. Cox proportional hazard regression analysis was used to estimate the hazard ratio (HR) of incident functional disability according to the presence of risk factors evaluated by the municipality’s self-assessment Basic Checklist (BCL). Evacuees from Iitate who participated in the exercise classes and those who did not were matched using the propensity scores, which were then used to obtain the HR of incident functional disability. Results: New functional disability occurred in 280 (24.2%) participants during the follow-up. Participants who scored negative for the “Physical function” domain in the BCL had a HR of 2.04 (95% CI: 1.54–2.69) for incident functional disability when compared to those who scored positive for this domain. Similarly, the HR for “Cognitive function” was 1.37 (CI: 1.06–1.77), and 1.60 (CI: 1.24–2.08) for “Depression”. Using a Cox proportional hazard regression model, both the group with low-participation in the exercise program and the group with high-participation in the exercise program had a significantly lower rate of incident functional disability compared to those who did not participate at all (HR = 0.27, CI: 0.16–0.46; HR = 0.30, CI: 0.12–0.74, respectively). Conclusions: Pre-disaster BCL domains were useful to identify individuals at risk of functional disability after a major socio-technical disaster. Therefore, this instrument can be used to identify at-risk older adults who would benefit from early exercise programs to prevent incident functional disability.
Suicide Rates in Evacuation Areas after the Fukushima Daiichi Nuclear Disaster: A 5-Year Follow-Up Study in Fukushima Prefecture Peer-reviewed

Masatsugu Orui, Yuriko Suzuki, Masaharu Maeda, Seiji Yasumura

Crisis　2018/04/05
Publisher: Hogrefe Publishing GmbH
DOI： 10.1027/0227-5910/a000509 　

ISSN： 2151-2396 0227-5910
東京電力の福島第一原子力発電所過酷事故後のメディア報道「県民健康調査」の価値劣化報道に対する批判 Peer-reviewed

杉田稔, 中山千尋, 佐藤理, 黒田佑次郎, 大類真嗣, 中山健夫, 安村誠司

健康開発　22　(3)　38-43　2018/03
Publisher: バイオコミュニケーションズ(株)
Factors associated with maintaining the mental health of employees after the fukushima nuclear disaster: Findings from companies located in the evacuation area Peer-reviewed

Masatsugu Orui, Yuriko Suzuki, Aya Goto, Seiji Yasumura

International Journal of Environmental Research and Public Health　15　(1)　35　2018/01/01
Publisher: MDPI AG
DOI： 10.3390/ijerph15010053 　

ISSN： 1660-4601 1661-7827
The relationship between starting to drink and psychological distress, sleep disturbance after the great east Japan earthquake and nuclear disaster: The Fukushima health management survey Peer-reviewed

Orui, M., Ueda, Y., Suzuki, Y., Maeda, M., Ohira, T., Yabe, H., Yasumura, S.

International Journal of Environmental Research and Public Health　14　(10)　1281　2017/10/24

DOI： 10.3390/ijerph14101281 　

ISSN： 1660-4601 1661-7827
Practical report on long-term disaster mental health services following the great east Japan earthquake: Psychological and social background of evacuees in Sendai City in the mid- to long-term post-disaster period Peer-reviewed

Orui, M., Harada, S., Hayashi, M.

Disaster Medicine and Public Health Preparedness　11　(4)　2017/03/22

DOI： 10.1017/dmp.2016.157 　

ISSN： 1938-744X 1935-7893
Development of mental health awareness tools for the young and result of peer-education practices utilizing its tool Peer-reviewed

36　(2)　18-26　2016/03
Publisher:
ISSN： 1883-6046
Delayed Increase in Male Suicide Rates in Tsunami Disaster-Stricken Areas following the Great East Japan Earthquake: A Three-Year Follow-Up Study in Miyagi Prefecture Peer-reviewed

Masatsugu Orui, Yasuhiro Sato, Kanako Tazaki, Ikuko Kawamura, Shuichiro Harada, Mizuho Hayashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　235　(3)　215-222　2015/03

DOI： 10.1620/tjem.235.215 　

ISSN： 0040-8727

eISSN： 1349-3329
多機関連携に重点を置いた仙台市の自殺対策の取り組みについて活動報告

大類真嗣, 渡邉みゆき, 佐藤泰啓, 田崎香菜子, 高橋悠佳, 林みづ穂

病院・地域精神医学　57　(2)　164,170-167,170　2015/03
Publisher: 日本病院・地域精神医学会
ISSN： 0910-4798
【精神科疫学入門】自殺の疫学最近の自殺の動向 Invited

大類真嗣

精神科　26　(1)　50-56　2015/01
Publisher: (有)科学評論社
ISSN： 1347-4790
うつ病による休職者を対象にした復職デイケアの実践復職と社会適応能力の関係を中心に Peer-reviewed

原田修一郎, 大類真嗣, 長谷川淳子, 野田承美, 森谷郁子, 高橋由里, 本庄谷奈央, 佐々木妙子, 伊藤真理子, 林みづ穂

精神科治療学　29　(12)　1601-1608　2014/12
Publisher: (株)星和書店
ISSN： 0912-1862

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うつ病で職場を休職し、復職デイケアに通所した48名を対象に、対象者のプログラム介入前後での抑うつ状態の尺度(Beck Depression Inventory-II:BDI-II)、社会適応能力の尺度(Social Adaptation Self-evaluation Scale:SASS)の変化、そして、デイケア終了時における復職率について後方視的に検討を行った。結果は、対象者全体で、介入前後でBDI-IIとSASSはともに有意に改善した。そして、終了時に56.3%(27名)が復職および復職に向けた活動をするに至った。さらに終了時の転帰によって、復職群(27名)と休職継続群(21名)の2群に分け比較したところ、終了時のBDI-IIの得点には有意差はなかったが、SASSの得点には有意差が認められた。本結果より、うつ病による休職者の復職には社会適応能力の改善が重要であることが示唆された。(著者抄録)
Changes in suicide rates in disaster-stricken areas following the Great East Japan Earthquake and their effect on economic factors: an ecological study Peer-reviewed

Orui, M., Harada, S., Hayashi, M.

Environmental Health and Preventive Medicine　19　(6)　459-466　2014/10

DOI： 10.1007/s12199-014-0418-2 　

ISSN： 1347-4715 1342-078X
Pleiotropic effect of common variants at ABO glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme Peer-reviewed

Kayama, T., Yamashita, H., Fukao, A., Kubota, I., Kato, T., Kitanaka, C., Sato, S., Ueno, Y., Konta, T., Shibata, Y., Watanabe, T., Abe, S., Miyamoto, T., Inoue, S., Miyashita, T., Ichikawa, K., Shishido, T., Arimoto, T., Takahashi, H., Nishiyama, S., Ikeda, A., Daimon, M., Kawanami, T., Wada, M., Arawaka, S., Oizumi, H., Kurokawa, K., Susa, S., Katou, Y., Kameda, W., Koyama, S., Karasawa, S., Iseki, C., Takahashi, Y., Kawata, S., Saito, T., Makino, N., Okumoto, K., Haga, H., Sato, T., Sato, C., Watanabe, H., Nishise, Y., Ishii, R., Matsuda, A., Tozawa, T., Honma, K., Narimatsu, H., Shibata, K., Miura, A., Inoue, R., Numazawa, A., Kudo, K., Aita, Y., Umezawa, N., Saito, Y., Takahashi, Y., Suzuki, Y., Otani, K., Hozawa, A., Shao, L., Orui, M., Kobayashi, A., Kanoya, Y., Hosoya, T., Suzuki, I., Otake, M., Morikagi, Y., Sekimata, A., Hiraka, M., Matsuda, Y., Takeda, Y., Matsunami, Y., Horie, T., Sato, S., Inoue, M., Baba, K., Tamiya, G., Ueki, M., Nakamura, T., Jambaldorj, J., Araki, S., Nakajima, O., Takahashi, K., Goto, K., Ishizaka, K.

PLoS ONE　9　(2)　2014

DOI： 10.1371/journal.pone.0055903 　

ISSN： 1932-6203
日常臨床における自殺予防の手引き平成25年3月版

中村純, 竹島正, 荒井稔, 田中克俊, 大塚耕太郎, 張賢徳, 大類真嗣, 羽藤邦利, 河西千秋, 廣川聖子, 黒木宣夫, 細田眞司, 廣尚典, 丸山総一郎, 阪上優, 渡辺洋一郎, 高橋祥友, 渡辺義文, 山口裕介, 日本精神神経学会精神保健に関する委員会

精神神経学雑誌　115　(3付録)　6-24　2013/03
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies Peer-reviewed

Shibata, K., Hozawa, A., Tamiya, G., Ueki, M., Nakamura, T., Narimatsu, H., Kubota, I., Ueno, Y., Kato, T., Yamashita, H., Fukao, A., Kayama, T., Kitanaka, C., Sato, S., Konta, T., Watanabe, T., Abe, S., Miyamoto, T., Inoue, S., Miyashita, T., Ichikawa, K., Shishido, T., Arimoto, T., Takahashi, H., Nishiyama, S., Ikeda, A., Daimon, M., Kawanami, T., Wada, M., Arawaka, S., Oizumi, H., Kurokawa, K., Susa, S., Katou, Y., Kameda, W., Koyama, S., Karasawa, S., Iseki, C., Takahashi, Y., Kawata, S., Saito, T., Makino, N., Okumoto, K., Haga, H., Sato, T., Sato, C., Watanabe, H., Nishise, Y., Ishii, R., Matsuda, A., Tozawa, T., Honma, K., Narimatsu, H., Miura, A., Inoue, R., Numazawa, A., Kudo, K., Aita, Y., Umezawa, N., Saito, Y., Takahashi, Y., Suzuki, Y., Otani, K., Shao, L., Orui, M., Kobayashi, A., Kanoya, Y., Hosoya, T., Suzuki, I., Otake, M., Morikagi, Y., Sekimata, A., Hiraka, M., Matsuda, Y., Sato, C., Takeda, Y., Matsunami, Y., Horie, T., Sato, S., Inoue, M., Baba, K., Jambaldorj, J., Araki, S., Nakajima, O., Takahashi, K., Goto, K., Ishizaka, K.

Molecular Genetics and Genomic Medicine　1　(1)　2013

DOI： 10.1002/mgg3.4 　

ISSN： 2324-9269
精神科医療における自殺予防精神科医療機関における自殺の経験および自殺予防に役立っていると考えられる取り組み

大類真嗣, 廣川聖子, 赤澤正人, 立森久輝, 川野健治, 森隆夫, 秋田宏弥, 竹島正

精神神経学雑誌　114　(12)　1420-1427　2012/12
地域住民を対象とした山形県うつ病予防対策事業と自殺率低下との関連性についての検討 Peer-reviewed

大類真嗣, 荒木京子, 石澤真由美, 有海清彦

公衆衛生　75　(11)　895-899　2011/11
Publisher: 医学書院
ISSN： 0368-5187
東日本大震災の被災地における心のケアチームの活動報告-被災者・支援者支援と災害時精神保健医療体制構築- Peer-reviewed

大類真嗣, 安部和明, 藤田俊浩, 渡部聡, 灘岡壽英

山形県病医誌　45　(2)　187-190　2011/07
Lifetime prevalence of mental disorders and its relationship to suicidal ideation in a Japanese rural community with high suicide and alcohol consumption rates Peer-reviewed

Orui, M., Kawakami, N., Iwata, N., Takeshima, T., Fukao, A.

Environmental Health and Preventive Medicine　16　(6)　384-389　2011/02

DOI： 10.1007/s12199-011-0209-y 　

ISSN： 1342-078X 1347-4715
Report of the measures for the smoke-free interventions at psychiatric hospital Peer-reviewed

45　(1)　58-63　2011/01
Publisher:
ISSN： 0389-0848
山形県における自殺死亡の地理的分布と人口動態的、社会経済的との関連性についての研究 Peer-reviewed

大類真嗣, 深尾彰

公衆衛生　71　(7)　623-627　2007/07
Publisher: 医学書院
ISSN： 0368-5187

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Introducing “bosai” communication science

小杉素子, 福島洋, 栗山進一, 佐藤健, 佐藤翔輔, GERSTER Juliam, 大類真嗣, 北村美和子, 藤本慎也, 尾島俊之, 岩本萌, 遠峰良美

日本リスク学会年次大会講演論文集(Web)　38th　2025
防災コミュニケーションによる行動変容:既往研究レビューと介入手法の探索

福島洋, 栗山進一, 佐藤健, 佐藤翔輔, ゲルスタユリア, 大類真嗣, 藤本慎也, 尾島俊之, 小杉素子, 岩本萌, 遠峰良美, 北村美和子

日本自然災害学会学術講演会講演概要集　44th　2025
東北メディカル・メガバンク機構(宮城)における循環器疾患発症調査の進捗

畑中里衣子, 畑中里衣子, 時岡紗由理, 時岡紗由理, 千葉一平, 千葉一平, 小暮真奈, 小暮真奈, 中谷久美, 中谷久美, 高瀬雅仁, 高瀬雅仁, 石黒真美, 石黒真美, 薄田海, 薄田海, 大類真嗣, 大類真嗣, 大類真嗣, 後岡広太郎, 後岡広太郎, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 小原拓, 小原拓, 中谷直樹, 中谷直樹, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

日本疫学会学術総会講演集(Web)　35th　2025
「次」につなぐ「周産期医療」-次回妊娠への対策と次世代への影響を考えるエコチル・スタディからみえてくるもの三世代の解析-環境省エコチル調査と東北大学東北メディカル・メガバンク計画三世代コホート調査に基づく展望

小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 篠田元気, 篠田元気, 大類真嗣, 大類真嗣, 栗山進一, 栗山進一, 栗山進一

周産期医学　54　(4)　2024

ISSN： 0386-9881
産後うつ・自殺問題の縦断的リスクと関連要因の検討:東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 篠田元気, 篠田元気, 村上慶子, 岩間憲之, 岩間憲之, 千葉一平, 千葉一平, 中谷久美, 中谷久美, 畑中里衣子, 畑中里衣子, 小暮真奈, 小暮真奈, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　34th　2024
妊婦の抗菌薬使用と児の問題行動との関連の検討:東北メディカル・メガバンク計画三世代コホート調査

阿部美有, 小原拓, 小原拓, 小原拓, 野田あおい, 野田あおい, 野田あおい, 森下啓, 小原竜, 高橋一平, 大瀬戸恒志, 篠田元気, 篠田元気, 大類真嗣, 大類真嗣, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　34th　2024
ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

岩崎史, 岩崎史, 中谷久美, 中谷久美, 山田充啓, 中谷直樹, 中谷直樹, 小暮真奈, 小暮真奈, 畑中里衣子, 畑中里衣子, 千葉一平, 千葉一平, 菅野郁美, 菅野郁美, 小原拓, 小原拓, 石黒真美, 石黒真美, 大類真嗣, 大類真嗣, 永家聖, 永家聖, 中村智洋, 中村智洋, 荻島創一, 荻島創一, 布施昇男, 布施昇男, 泉陽子, 泉陽子, 栗山進一, 栗山進一, 栗山進一, 杉浦久敏, 寳澤篤, 寳澤篤

日本疫学会学術総会講演集(Web)　34th　2024
東北メディカル・メガバンク計画地域住民コホート調査(宮城):これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 小原拓, 宇留野晃, 布施昇男, 泉陽子, 栗山進一, 栗山進一, 寳澤篤

日本疫学会学術総会講演集(Web)　34th　2024
The Association of Urinary Sodium-to-Potassium Ratio and Estimated Urinary Sodium Excretion with Atrial Fibrillation among Participants without Hypertension

時岡紗由理, 中谷直樹, 中谷直樹, 畑中里衣子, 畑中里衣子, 中谷久美, 中谷久美, 千葉一平, 千葉一平, 小暮真奈, 小暮真奈, 後岡広太郎, 後岡広太郎, 後岡広太郎, 大類真嗣, 大類真嗣, 宇留野晃, 宇留野晃, 小林朋子, 小林朋子, 小林朋子, 児玉栄一, 児玉栄一, 児玉栄一, 濱中洋平, 濱中洋平, 布施昇男, 布施昇男, 布施昇男, 寳澤篤, 寳澤篤

日本循環器学会学術集会(Web)　88th　2024
妊婦の睡眠障害と児のアレルギー疾患発症との関連:三世代コホート調査

植松亜美, 大類真嗣, 大類真嗣, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 野田あおい, 篠田元気, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

日本衛生学雑誌(Web)　79　(Supplement)　2024

ISSN： 1882-6482
Tohoku Medical Megabank Project Three-Generation Cohort Study 10-year efforts and perinatal outcomes

石黒真美, 小原拓, 黒田真帆, 村上慶子, 野田あおい, 篠田元気, 大類真嗣, 岩間憲之, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 寳澤篤, 栗山進一

DOHad研究(Web)　12　(1)　2024

ISSN： 2187-2597
妊娠初期の麻黄含有漢方薬の使用と児の先天異常の関連:東北メディカル・メガバンク計画三世代コホート調査

野田あおい, 小原拓, 野田あおい, 小原拓, 野田あおい, 小原拓, 松崎芙実子, 鈴木聡子, 有田龍太郎, 大澤稔, 有田龍太郎, 大澤稔, 小原竜, 森下啓, 森下啓, 上野史彦, 篠田元気, 大類真嗣, 篠田元気, 大類真嗣, 村上慶子, 石黒真美, 菊地章子, 高山真, 石井正, 川目裕, 石黒真美, 菊地章子, 高山真, 石井正, 川目裕, 呉繁夫, 栗山進一, 栗山進一, 栗山進一

日本先天異常学会学術集会プログラム・抄録集　64th　2024
東日本大震災による母親の惨事ストレスと児の問題行動との関連について

田邉竣, 大類真嗣, 大類真嗣, 河口千奏, 篠田元気, 野田あおい, 野田あおい, 石黒真美, 石黒真美, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

日本トラウマティック・ストレス学会大会プログラム・抄録集　23rd　2024
「防災コミュニケーション」による災害リスク大幅低減の方略

福島洋, 栗山進一, 佐藤健, 佐藤翔輔, ゲルスタユリア, 尾島俊之, 小杉素子, 岩本萌, 大類真嗣, 北村美和子

日本自然災害学会学術講演会講演概要集　43rd　2024
両親の高血圧・糖尿病・脂質異常症の既往と娘の妊娠高血圧症候群

石黒真美, 石黒真美, 小原拓, 小原拓, 小原拓, 野田あおい, 野田あおい, 野田あおい, 篠田元気, 岩間憲之, 岩間憲之, 大類真嗣, 大類真嗣, 村上慶子, 菊谷昌浩, 目時弘仁, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

日本妊娠高血圧学会雑誌　30　2024

ISSN： 1880-3172
健康的な生活習慣と新型コロナウイルス感染・新型コロナワクチン接種の効果との関連

大類真嗣, 大類真嗣, 小原拓, 小原拓, 石黒真美, 石黒真美, 野田あおい, 野田あおい, 村上慶子, 中村智洋, 中村智洋, 中村智洋, 目時弘仁, 目時弘仁, 目時弘仁, 中谷直樹, 中谷直樹, 寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　83rd　2024
東北メディカル・メガバンク計画三世代コホート調査:小児発達に関する調査の進捗

大類真嗣, 石黒真美, 松岡卓哉, 野田あおい, 篠田元気, 小原拓, 栗山進一, 栗山進一

東北公衆衛生学会講演集　73rd (CD-ROM)　2024

ISSN： 0915-549X
Dietary-Wide Association Studyによる妊婦の食事摂取情報とSmall for Gestational Age児の出産との関連の探索と検証:東北メディカル・メガバンク計画三世代コホート調査

高橋一平, 小原拓, 小原拓, 小原拓, 大瀬戸恒志, 篠田元気, 篠田元気, 野田あおい, 野田あおい, 野田あおい, 村上慶子, 村上慶子, 大類真嗣, 大類真嗣, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

DOHad研究(Web)　12　(3)　2024

ISSN： 2187-2597
父母と小児の眼科的検査値の関連:三世代コホート調査

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 宇留野晃, 吉田清香, 高田菜生子, 藤岡俊亮, 西村尭幸, 中澤徹, 布施昇男, 布施昇男, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　34th　(Suppl.)　172-172　2024
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析:東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

東北公衆衛生学会講演集　72nd　2023

ISSN： 0915-549X
東北メディカル・メガバンク計画地域住民コホート調査(宮城):これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 村上慶子, 小原拓, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023
東北メディカル・メガバンク計画三世代コホート調査:これまでの進捗

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寶澤篤, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023
母子健康情報と学校健康診断情報との連係情報の活用可能性の検討

篠田元気, 黒川修行, 野田あおい, 野田あおい, 大類真嗣, 大類真嗣, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 小原拓, 小原拓, 目時弘仁, 目時弘仁, 栗山進一, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023
東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023
コホート調査データの連係・活用推進のための基盤整備-マイToMMoの開発と実装-

野田あおい, 篠田元気, 石黒真美, 千葉一平, 大類真嗣, 村上慶子, 小原拓, 菅野郁美, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集(CD-ROM)　82nd　2023
妊婦初期における麻黄含有漢方薬の使用と出生児の先天形態異常の関連:東北メディカル・メガバンク計画三世代コホート調査

野田あおい, 野田あおい, 野田あおい, 小原拓, 小原拓, 小原拓, 松崎芙実子, 松崎芙実子, 小原竜, 小原竜, 森下啓, 上野史彦, 上野史彦, 篠田元気, 篠田元気, 大類真嗣, 大類真嗣, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 栗山進一, 栗山進一, 栗山進一

日本医療薬学会年会講演要旨集(Web)　33rd　2023

ISSN： 2424-2470
東日本大震災後の自殺に関する文献レビュー

大類真嗣, 大類真嗣

日本自殺予防学会総会プログラム・抄録集　46th　2022
東日本大震災後の支援者向けメンタルヘルスに関するオンデマンド研修プログラムの実装

大類真嗣

日本公衆衛生学会総会抄録集(CD-ROM)　81st　2022
東日本大震災における復興期における自殺死亡率の動向-震災後10年間の経過-

大類真嗣

日本社会精神医学会プログラム・抄録集　40th　2021
精神保健福祉の日進月歩第57回薬物依存に関する自助グループと連携した啓発活動-高校生への保健講話から-

寺澤彩, 我妻ひろみ, 大類真嗣, 小堺幸, 林みづ穂

公衆衛生情報　50　(12)　2021
放射線健康不安改善のためのゲートキーパー向け研修プログラムの開発とその評価

大類真嗣, 大類真嗣, 深澤舞子, 堀越直子, 鈴木友理子, 川上憲人

日本公衆衛生学会総会抄録集　79th　2020

ISSN： 1347-8060
災害による避難を経験した地域在住高齢者の精神的健康度に関連する因子の探索身体活動および身体活動規定因子に着目して

森山信彰, 西間木ます子, 大類真嗣, 岩佐一, 黒田佑次郎, 小野道子, 佐藤紀子, 岡崎可奈子, 高村元章, 安村誠司

理学療法学　46　(Suppl.1)　O-8　2019/08
Publisher: (公社)日本理学療法士協会
ISSN： 0289-3770
福島第1原子力発電所事故後の避難者における放射線による健康不安とメディア利用との関連

大類真嗣, 中山千尋, 黒田佑次郎, 森山信彰, 岩佐一, 堀内輝子, 中山健夫, 杉田稔, 安村誠司

福島県保健衛生雑誌　32　38-38　2018/09
Publisher: 日本公衆衛生協会-福島県支部
複合災害被災者の幸福度・精神的健康に影響を与える要因の検討

竹林(兼子)唯, 大類真嗣, 中島聡美, 中島聡美, 桃井真帆, 桃井真帆, 伊藤亜希子, 伊藤亜希子, 前田正治, 前田正治, 安村誠司, 安村誠司, 大戸斉

日本認知・行動療法学会大会抄録集(CD-ROM)　44th　2018

ISSN： 2433-3050
飯舘村民の避難指示解除後の生活とその課題~保健師からの視点~

赤石澤愛, 松田久美子, 八代千賀子, 大河原愛美, 五所俊輔, 児山洋平, 大類真嗣, 黒田佑次郎, 坪倉正治

福島県保健衛生雑誌　32　2018
福島第一原子力発電所事故後の放射線健康不安に対する情報の影響

中山千尋, 杉田稔, 中山健夫, 黒田佑次郎, 大類真嗣, 堀内輝子, 岩佐一, 安村誠司

日本公衆衛生学会総会抄録集　76回　597-597　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
福島第一原子力発電所事故後の放射線健康不安に対する情報の影響

中山千尋, 杉田稔, 中山健夫, 黒田佑次郎, 大類真嗣, 堀内輝子, 岩佐一, 安村誠司

福島県保健衛生雑誌　30　39-39　2017/09
Publisher: 日本公衆衛生協会-福島県支部
こころの健康改善のためのハーバルメディスンの使用頻度横断研究による日米比較

岩永麻衣, 川上憲人, 大野裕, 中根允文, 中村好一, 深尾彰, 堀口逸子, 立森久照, 岩田昇, 宇田英典, 中根秀之, 渡邉至, 大類真嗣, 船山和志, 長沼洋一, 古川壽亮, 畑幸宏, 小林雅與, 阿彦忠之, 山本祐子, 竹島正

日本公衆衛生学会総会抄録集　75回　288-288　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
原子力発電所事故による避難区域内の自殺死亡率の推移

大類真嗣, 黒田佑次郎, 伊藤慎也, 岩佐一, 鈴木友理子, 前田正治, 安村誠司

日本公衆衛生学会総会抄録集　75回　584-584　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
原子力発電所事故により全域が避難区域に指定された市町村の自殺死亡率の推移

大類真嗣, 黒田佑次郎, 伊藤慎也, 岩佐一, 鈴木友理子, 前田正治, 安村誠司

福島県保健衛生雑誌　28　38-38　2016/09
Publisher: 日本公衆衛生協会-福島県支部
東京電力の福島原子力発電所過酷事故後のメディア報道

杉田稔, 中山千尋, 佐藤理, 黒田佑次郎, 大類真嗣, 堀内輝子, 中山健夫, 安村誠司

日本ヘルスコミュニケーション学会学術集会プログラム・抄録集　8回　37-37　2016/09
Publisher: 日本ヘルスコミュニケーション学会
精神科医療の場で経験している自殺の現状について

大類真嗣, 廣川聖子, 赤澤正人, 立森久照, 川野健治, 森隆夫, 秋田宏弥, 竹島正

日本社会精神医学会雑誌　21　(3)　453-453　2012/08
Publisher: (一社)日本社会精神医学会
ISSN： 0919-1372
地域住民における「ひきこもり」経験の頻度と精神障害の関連

小山明日香, 三宅由子, 立森久照, 長沼洋一, 川上憲人, 土屋政雄, 竹島正, 大野裕, 中根允文, 中村好一, 深尾彰, 堀口逸子, 岩田昇, 宇田英典, 中根秀之, 渡邉至, 大類真嗣, 船山和志, 古川壽亮, 畑幸宏, 小林雅與, 阿彦忠之, 山本祐子, 吉川武彦, WMH-J Survey Group

国立精神・神経センター精神保健研究所年報　(21)　264-264　2009/03
Publisher: (国研)国立精神・神経医療研究センター精神保健研究所
ISSN： 0915-0056
気分障害経験者の受療行動の関連要因についての検討

大類真嗣, 邵力, 深尾彰

日本公衆衛生学会総会抄録集　67回　550-550　2008/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域住民を対象とした自殺念慮と精神疾患の関連性に関する研究

大類真嗣, 渡辺みさ子, 邵力, 石川仁, 深尾彰

山形県公衆衛生学会講演集　34回　37-38　2008/03
Publisher: 山形県公衆衛生学会
こころの健康に関する疫学調査から判明したわが国の自殺関連行動の現況

勝又陽太郎, 立森久照, 竹島正, 川上憲人, 大野裕, 中根允文, 中村好一, 深尾彰, 堀口逸子, 岩田昇, 宇田英典, 中根秀之, 渡邉至, 大類真嗣, 長沼洋一, 船山和志, 古川壽亮, 畑幸宏, 小林雅與, 阿彦忠之, 三宅由子, 山本祐子, 吉川武彦, WMH-J, Survey Group

国立精神・神経センター精神保健研究所年報　(20)　212-212　2007/10
Publisher: (国研)国立精神・神経医療研究センター精神保健研究所
ISSN： 0915-0056
地域住民における精神疾患と自殺念慮の合併リスクと受療相談行動について

大類真嗣, 邵力, 石川仁, 深尾彰

日本公衆衛生学会総会抄録集　66回　556-556　2007/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域住民のこころの健康についての実態について「こころの健康についての疫学調査」より

大類真嗣, 邵力, 石川仁, 竹島正, 川上憲人, 深尾彰

東北公衆衛生学会誌　(56)　28-28　2007/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
山形県内の一地域における自殺行動の頻度について

大類真嗣, 邵力, 石川仁, 深尾彰

日本公衆衛生学会総会抄録集　65回　858-858　2006/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
山形県における地区別の肺癌死亡率の変遷

加藤博久, 大類真嗣, 深尾彰, 大泉弘幸, 貞弘光章, 若林一郎

日本公衆衛生学会総会抄録集　64回　593-593　2005/08
Publisher: 日本公衆衛生学会
ISSN： 1347-8060

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Books and Other Publications 3

トラウマ関連疾患心理恵用法ガイドブック

前田正治, 大江美佐里

誠信書房　2017/09/30
公衆衛生第80巻第4号

医学書院

その他の出版機関　2016/04
精神科第26巻第1号

科学評論社

科学評論社　2015/01

Presentations 28

震災後の心理的苦痛と災害ストレス症状・被災体験を用いた自殺死亡のスクリーニング

大類真嗣

第84回日本公衆衛生学会　2025/10/29
第84回日本公衆衛生学会シンポジウム「疫学研究から考える災害後の自殺対策」被災者の自殺死亡者のリスクの検討と宮城県沿岸部の自殺死亡率の推移から見たアウトリーチの効果

大類真嗣

第84回日本公衆衛生学会　2025/10/29
第84回日本公衆衛生学会総会「巨大災害の根本的問題へ公衆衛生の力で挑戦する～直接死を防ぐ災害一次予防～」住民の行動変容を促進させるための社会的介入の一案

大類真嗣

第84回日本公衆衛生学会　2025/10/28
産業衛生領域での災害レジリエンスの強化：災害後の生活習慣と職場内のコミュニケーションによる精神保健の保持

大類真嗣

第98回日本産業衛生学会シンポジウム12「仙台防災枠組みと災害産業保健」　2025/05/15
東北メディカル・メガバンク計画三世代コホート調査の小児発達に関する調査の進捗とGazefinder®を用いた解析

大類真嗣, 石黒真美, 小原拓, 野田あおい, 篠田元気, 村上慶子, 目時弘仁, 菊谷昌浩, 中谷直樹, 寳澤篤, 栗山進一

第35回日本疫学会総会　2025/02/13
健康的な生活習慣と新型コロナウイルス感染・新型コロナワクチン接種の効果との関連

大類真嗣, 小原拓, 石黒真美, 野田あおい, 村上慶子, 中村智洋, 目時弘仁, 中谷直樹, 寳澤篤, 栗山進一

第83回日本公衆衛生学会総会　2024/10/31
産後うつ・自殺問題の縦断的リスクと関連要因の検討：東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 岩間憲之, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 目時弘仁, 菊谷昌浩, 中谷直樹, 寳澤篤, 栗山進一

第34回日本疫学会総会　2024/02/02
東北メディカル・メガバンク計画三世代コホート調査：これまでの進捗

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

第82回日本公衆衛生学会総会　2023/10/31
東日本大震災後の支援者向けメンタルヘルスに関するオンデマンド研修プログラムの実装

大類真嗣

第82回日本公衆衛生学会総会　2022/10/09
東日本大震災後の自殺に関する文献レビュー

大類真嗣

第46回日本自殺予防学会　2022/09/11
東日本大震災の被災地での被災者支援・自殺対策-支援の継続と職員への継承-

大類真嗣, 佐伯涼香, 下村瑞希, 細川護之, 君市祐子, 田中充, 大友明子, 門田亜希, 小堺幸, 原田修一郎, 林みづ穂

第45回日本自殺予防学会　2021/09/04
放射線健康不安改善のためのゲートキーパー向け研修プログラムの開発とその評価

大類真嗣, 深澤舞子, 堀越直子, 鈴木友理子, 川上憲人

第79回日本公衆衛生学会総会　2020/10/20
Increased in Male Suicide Rates after Termination of Providing Temporary-housings following the Great East Japan Earthquake - A Eight-Year Follow-Up Study -

Masatsugu ORUI

International Association of Suicide Prevention, IASP 2019. Derry, London Derry, UK　2019/09/19
福島第1原子力発電所事故による避難区域内の自殺・メンタルヘルス対策と今後の方向性

大類真嗣, 黒田佑次郎, 安村誠司

第77回日本公衆衛生学会総会　2018/10/26
原子力発電所事故後からの福島県民の精神的な回復に関連する要因は？

大類真嗣, 中島聡美, 竹林唯, 伊藤亜希子, 桃井真帆, 前田正治, 安村誠司, 大戸斉

第77回日本公衆衛生学会総会　2018/10/24
福島第1原子力発電所事故後の避難者における放射線による健康不安とメディア利用との関連

大類真嗣, 中山千尋, 黒田佑次郎, 森山信彰, 岩佐一, 堀内輝子, 中山健夫, 杉田稔, 安村誠司

平成30年度福島県保健衛生学会　2018/09/07
原子力発電所事故による避難区域内の自殺の動向

大類真嗣, 鈴木友理子, 前田正治, 安村誠司

第76回日本公衆衛生学会　2017/11/01
東日本大震災および原子力発電所事故後の勤労者の精神的健康を保持する要因の検討

大類真嗣, 鈴木友理子, 後藤あや, 佐藤理, 安村誠司

第76回日本公衆衛生学会　2017/11/01
原子力災害の避難区域における自殺死亡率の動向と対策への考察

大類真嗣, 黒田佑次郎, 鈴木友理子, 前田正治, 安村誠司

平成29年度福島県保健衛生学会　2017/09/15
The relationship between psychology, socioeconomics, and social networks and starting to drink among evacuees after the Great East Japan earthquake and nuclear disaster: The Fukushima Health Management Survey International-presentation

Masatsugu Orui, Yuka Ueda, Yuriko Suzuki, Masaharu Maeda MD, Tetsuya Ohira, Hirooki Yabe, Seiji Yasumura on, behalf of, the Mental Health, Group of the, Fukushima Health, Management Survey

The 21st International Epidemiological Association World Congress of Epidemiology (WCE2017)　2017/08/20
原子力発電所事故後の労働者の身体的・精神的健康への影響

大類真嗣, 鈴木友理子, 後藤あや, 佐藤理, 安村誠司

第66回東北公衆衛生学会　2017/07/28
東日本大震災後被災後の新たな飲酒開始と心理的・社会経済的背景およびソーシャルネットワークとの関連

大類真嗣, 上田由桂, 鈴木友理子, 前田正治, 安村誠司

第27回日本疫学会学術総会　2017/01/27
原子力発電所事故による避難区域内の自殺死亡率の推移

大類真嗣, 黒田佑次郎, 伊藤慎也, 岩佐一, 鈴木友理子, 前田正治, 安村誠司

第75回日本公衆衛生学会学術総会　2016/10/26
原子力発電所事故により全域が避難区域に指定された市町村の自殺死亡率の推移

大類真嗣, 黒田佑次郎, 伊藤慎也, 岩佐一, 鈴木友理子, 前田正治, 安村誠司

平成28年度福島県保健衛生学会　2016/09/02
東日本大震災の外部支援者としての経験と被災地内の精神保健福祉、社会生活上の問題

大類真嗣

第15回日本トラウマティック・ストレス学会　2016/05/21
Changes in suicide rates in tsunami disaster-stricken areas following the Great East Japan earthquake–three-year follow-up after the disaster International-presentation

Masatsugu Orui

World Psychiatry Association (WPA) section on Epidemiology and Public health　2013/10/16
Reduced suicide rates in disaster-stricken and neighboring areas following the Great East Japan Earthquake International-presentation

Masatsugu Orui

27th International Association for Suicide Prevention　2012/09/25
精神科医療機関における自殺の経験および自殺予防に役立っていると考えられる取組

大類真嗣

第108回日本精神神経学会総会　2012/05

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Research Projects 10

災害に備える医療的ケア児支援強化のための教育手法の開発

中村裕子, 吉岡早戸, 大類真嗣, 河崎和子, 前垣義弘, 栗山進一, 本間正人, 齊藤良玄

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 鳥取大学

2025/04/01 - 2028/03/31
大規模災害後の間接的死亡の検討：特定非常災害を網羅した災害後の超過死亡の一般化

大類真嗣, 岩本萌, 江川新一, 栗山進一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04 - 2028/03
発達障がいが疑われる小児に対する新しい診断的評価～開発から社会実装へ

土屋賢治, 大類真嗣, 三宅吉博, 田中景子, 西村倫子

Offer Organization: 国立研究開発法人日本医療研究開発機構

System: 成育疾患克服等総合研究事業

Category: 令和５年度成育疾患克服等総合研究事業周産期・小児期・生殖期のライフステージに応じた疾病・健康課題に関する研究開発（３）発達障害の早期介入に向けた診断・評価技術開発

2023/10 - 2026/03
成育疾患克服等総合研究事業「発達障がいが疑われる小児に対する新しい診断的評価～開発から社会実装へ」

Offer Organization: 国立研究開発法人日本医療研究開発機構

2023/10 - 2026/03
東日本大震災の被災者の生活支援を行う支援者向けメンタルヘルスに関する研修プログラムの開発 ―コロナ禍にも対応したオンライン研修プログラムの実装―

Offer Organization: 公益財団法人明治安田こころの健康財団

System: 2021年研究助成

Institution: 仙台市精神保健福祉総合センター

2021/08 - 2022/07
Health anxiety due to information about health effect by radiation and evaluation of its intervention

Yasumura Seiji

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Fukushima Medical University

2018/04/01 - 2021/03/31

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The purpose of this study was to develop an intervention to increase the confidence of kindergarten teachers in their ability to respond to consultations about concerns caused by radiation and other health risks. After consenting to participate, study participants were administered a questionnaire regarding earthquakes, knowledge, and literacy. one group (the first half group) was given the program using ZOOM. The other group (second half group) was given only the materials. Both groups improved their knowledge. In addition, confidence and literacy improved after participation in the first half group. The results suggest that direct participation in the program, as well as the provision of materials, was beneficial.
Acquisition of resilience among affetected people by the Fukushima Combinedd Disaster

Ohto Hitoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Fukushima Medical University

2016/04/01 - 2020/03/31

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The 2011 Fukushima Disater has brought psychological distress. To clarify the factos associated with mental health recovery, a cross-sectional questionnaire survey was conducted. Subjects associated with Resilience, Recovery, and Remitting patterns of mental status were categorized in the Recovery group, while those associated with Delayed/Chronic dysfunction were placed in the Non-recovered group. Disaster-related unemployment (OR: 0.80) and economic hardship (OR: 0.80) were associated with the hindrance of recovery. In contrast, overall good health (OR: 1.47), regular physical activity (OR: 1.23), social interaction with friends (OR: 1.25), and established social roles (OR: 1.44) were associated with the promotion of recovery. Our study showed a positive association between mental health recovery and a desirable lifestyle and social network, particularly with social roles. The provision of active social roles promote recovery related to a disaster as with multi-faceted support.
福島第1原子力発電所事故による避難指示解除後の地域精神保健福祉体制の構築に向けて-地域支援と家族支援の在り方の検討- Competitive

Offer Organization: 公益財団法人明治安田こころの健康財団

System: 2017年研究助成

2017/09 - 2018/06

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・東日本大震災が発生し、その結果被災地での精神科病院の機能が停止し、入院中の精神障がい者の被災地外への転院、搬送を余儀なくされた。また外来通院中の患者に関しても被災地内の精神科医療機関や福祉サービスの機能停止により、こころのケアチームなどがその代替を担った状況であった。一方でこうした災害直後のみならず、仮設住宅での避難生活を経て、自宅へ帰還する段階である復興期においてでも、生活環境の変化により、精神症状に変化を来す可能性があり、特に東京電力福島第1原子力発電所事故（以下「原子力発電所事故」という。）による避難指示が解除された市町村においてでは、元々あった医療保健福祉資源が事故前の状況に十分に回復しておらず、帰還後の状態悪化の要因になりうることが懸念される。また、避難指示解除後の市町村における精神保健福祉体制の現状から事故前の自宅に帰還しないといった選択する当事者とその家族がいることが想定される。・今回、原子力発電所事故による避難指示が29年3月末に解除された福島県飯舘村を対象地域とし、帰還後の地域の精神保健医療福祉体制の構築の基礎資料とするため、対象地域内の当事者並びにその家族に対する面接を行うものとする。併せて、面接を通じて当事者並びにその家族の訴えの傾聴や相談対応、関係機関との連絡調整といった当事者への支援や家族支援につなげていく。
Suicide rates in evacuation areas after the Fukushima Daiichi nuclear disaster: An observation for transition of suicide rate and discussion with measurements for suicide

Orui Masatsugu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Fukushima Medical University

2016/04 - 2018/03

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Associations between nuclear disasters and suicide have been examined to a limited extent. The aim is to clarify suicide rates in evacuation areas after the nuclear disaster in Fukushima. This descriptive study used monthly data from vital statistics between March 2009 and December 2015. Suicide rates in the evacuation areas were compared with the national average. Male suicide rates in evacuation areas increased significantly immediately after the disaster, and then began to increase again after 4-year in post-disaster. Female rates declined slightly during the first year and then increased significantly over the subsequent 3-year. Suicide rate in both gender exceeded the rates in non-evacuation areas at 4.5 years post-disaster, and showed an increasing trend thereafter. Our findings suggest the need to keep in mind that, when providing post-disaster mental health services, suicide rates can eventually increase even if they initially decrease.
東日本大震災および原子力発電所事故後の勤労者の身体的・精神的健康度への影響 Competitive

大類真嗣

Offer Organization: 福島県労働保健センター

System: 平成25年研度究助成

2016/03 - 2017/02

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Teaching Experience 11

Public Health, Disaster Public Health and Health Crisis Management　Tohoku University
Epidemiology　Tohoku Fukushi University
Public Health, Disaster Public Health　Tohoku University
Epidemiology, Molecular epidemiology　Tohoku University
Mental Disorders and Treatments　Tohoku Gakuin University
社会医学・医療学（公衆衛生学・衛生学講座）精神保健　山形大学医学部
スポーツと医学「スポーツと予防医学」　福島県立医科大学
総括講義（保健医療論・公衆衛生学）　福島県立医科大学
社会医学コース（公衆衛生学）　福島県立医科大学
疫学・統計の方法論　福島県立医科大学
疫学・統計の方法論、疫学・統計実習　福島県立医科大学

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Social Activities 22

山形県北部豪雨災害の被災自治体（戸沢村）支援”職員向けゲートキーパー研修: 被災した住民のこころの健康を守るための「気づき」「声かけ」「つなぐ」”

2026/03/17 - 2026/03/17
朝日新聞（宮城県版）沿岸部の自殺率高止まり傾向から全国水準並みに：ケア「地域から個別へ重点」

朝日新聞

2026/02/14 - 2026/02/14
災害に備える：直接死亡を防ぐための事前防災と健康影響を最小限にするために

むし歯サミット in 新庄2025

2025/11/15 - 2025/11/15
日本精神神経学会精神保健に関する委員会

2012 - 2015

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対象 : 日本精神神経学会
令和6年度太白こころの健康づくり講座「若者のメンタルヘルスについて」ロールプレイ

2025/03 -
令和6年度仙台市青葉区専門学校教職員向けメンタルヘルス勉強会「ゲートキーパー養成研修」ロールプレイ

2024/12 -
令和5年度仙台市青葉区専門学校教職員向けメンタルヘルス勉強会「気づく，聴く，見守る，つなげるためのポイント」ロールプレイ

2023/12 -
令和5年度大和町ゲートキーパー養成研修会「働き盛り世代のメンタルヘルス対策 -気づく・声をかける・話を聞く・見守る-」

2023/09 -
仙台市健康福祉局障害者支援課「自殺対策に関連する支援機関職員向けガイドブック（若年者向け）（高齢者向け）（就業者向け）（女性向け）（無職者向け）」監修

2023/03 -
令和4年度青葉区家庭健康課こころの健康づくり講演会「地域での支えあい～それぞれの立場でできること～」

2022/10 -
復興公営住宅支援者向け研修プログラム「せんだいTube「メンタルヘルス問題や認知症を抱えた住民を支えるために」」開発

https://www.youtube.com/watch?v=WZFV-uV977M

2022/01 -
令和3年度仙台市社会福祉協議会青葉区復興公営住宅情報交換会「いま考える見守りの重要性」

2022/01 -
令和2年度仙台市社会福祉協議会青葉区復興公営住宅情報交換会「精神障害を持つ方への接し方について」

2021/02 -
令和2年度東北学院大学業種別研修「コロナ禍におけるメンタルヘルス –これから起こり得ることとその具体的対応-」

2020/08 -
平成30年度飯舘村自殺予防ゲートキーパー研修会「身近な人を自殺から守りませんか? ～気づき、声かけ、つなぐ～」

2019/03 -
平成30年度県南保健福祉事務所自殺予防セミナー「自殺予防について～いま、私たちができること～」

2019/02 -
平成30年度飯舘村自殺計画策定に向けた職員研修「行政における自殺対策のあり方と自殺計画について」

2018/11 -
平成30年度飯舘村自殺予防対策庁内連絡会議「行政における自殺対策のあり方と自殺対策計画について」

2018/10 -
平成29年度いわき市自殺予防対策庁内連絡会議「行政における自殺対策のあり方と自殺対策計画について」

2018/03 -
平成29年度福島県医師会勤務環境改善研修会「医療機関での受動喫煙防止対策と健康経営」

2017/10 -
平成29年度飯舘村放射線相談員等研修プログラム「震災後のメンタルヘルス～気になる人に声をかけて支えていこう～」

2017/08 -
平成28年度県北保健福祉事務所ゲートキーパー養成講座「思春期における精神疾患‐ゲートキーパーとして押さえておきたい基本-」

2017/01 -

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Media Coverage 1

朝日新聞（宮城県版）沿岸部の自殺率高止まり傾向から全国水準並みに：ケア「地域から個別へ重点」

朝日新聞　https://www.asahi.com/articles/ASV272D09V27UNHB01BM.html

2026/02

Type: Newspaper, magazine