Details of the Researcher

PHOTO

Yushi Ezoe
Section
Graduate School of Dentistry
Job title
Assistant Professor
Degree

  • PhD(Dentistry) (Tohoku University)

e-Rad No.
50755171

Education 2

  • Tohoku University　Oral and Maxillofacial Surgery

    2011/04 - 2015/03

  • Tohoku University

    2004/04 - 2010/03

Professional Memberships 6

  • 日本口腔インプラント学会

    2015/05 -

  • 日本口腔外科学会

    2012/02 -

  • 日本再生医療学会

  • 日本有病者歯科医療学会

  • 日本口腔科学会

  • 日本顎関節症学会

︎Show all ︎Show first 5

Research Interests 3

  • MRONJ

  • biomaterials

  • bone regeneration

Research Areas 1

  • Life sciences / Regenerative dentistry and dental engineering / bone regeneration

Papers 49

  1. 精神発達遅滞を有した患者の咀嚼筋腱・腱膜過形成症に対し長期管理を行った1例

    江副祐史, 野上晋之介, 梶田倫功, 芦田桂樹, 山内健介

    日本顎関節学会雑誌　2026/04

  2. Bonegraft Using Octacalcium Phosphate Collagen Composite with Teriparatide and Polylactic Acid Cage. International-journal

    Atsumu Kouketsu, Ryosuke Iwama, Yushi Ezoe, Keiko Matsui, Toshiki Yanagisawa, Tetsu Takahashi, Tsuyoshi Sugiura, Shinji Kamakura

    Tissue engineering. Part A　2025/11/21

    DOI： 10.1177/19373341251396158 　

    More details Close

    Octacalcium phosphate (OCP) is a bone grafting material known for its biocompatibility, osteoconductive, and osteogenic properties. Current treatments for extensive jaw defects often involve vascularized bone grafts or titanium mesh-based osteogenesis, which have limitations such as graft resorption, infections, and reoperation needs. In this study, a new bone regeneration therapy was explored, in which OCP combined with collagen (Col), treated with teriparatide (TPTD), was encased in a polylactic acid (PLA) cage to enhance structural stability and promote controlled bone formation. The therapeutic effects of this approach were evaluated using a rat model for calvarial regeneration, employing immunohistochemical staining. TPTD-treated OCP/Col composites were encased in cylindrical PLA cages, which were created using a 3D printer, and implanted into rat skulls. Three cage designs were tested: no holes, one large hole, and several small holes. Following implantation, the specimens underwent microcomputed tomography (micro-CT), histological, and immunohistochemical analyses to assess bone regeneration. In the micro-CT analysis, radiopacity at the OCP/Col graft site was higher in the "no hole" cage group than in the other groups from 4 to 12 weeks after implantation, particularly in the marginal area and region adjacent to the bone. Histological analysis revealed that, in all groups, new bone formation was observed along the surface of the skull 12 weeks postimplantation. In the "no hole" cage group, bone formation extended to the upper middle section, and bone matrix was present in areas where mature bone formation was lacking. In the other two groups, fibrous tissue filled the holes in the PLA cage, and no bone formation was observed directly beneath the holes. Immunohistochemical analysis revealed the expression of osteopontin, osteocalcin, runt-related transcription factor 2, vascular endothelial growth factor, and collagen I in all groups. The "no hole" cage group exhibited uniform and successful bone formation, with these cell markers consistently observed throughout all regions. These results suggest that using PLA cages to cover TPTD-treated OCP/Col discs effectively promotes bone regeneration. This approach provides a promising alternative to conventional bone grafting techniques and may help overcome the limitations associated with free or autologous bone grafts in oral and maxillofacial reconstruction. Impact Statement This study demonstrates that encasing teriparatide-treated octacalcium phosphate/collagen composites in polylactic acid (PLA) cages enhances bone regeneration. Using a rat model, microcomputed tomography, histological, and immunohistochemical analyses revealed that the "no hole" PLA cage design promoted uniform and successful bone formation, whereas perforated cages led to fibrous tissue infiltration. These findings highlight the potential of PLA cages in optimizing bone grafting strategies, offering a promising approach for tailored bone regeneration therapies.

  3. Influence of parallel holes in bone regenerative material for vertical bone augmentation Peer-reviewed

    Toshiki Yanagisawa, Keiko Matsui, Yushi Ezoe, Atsumu Kouketsu, Kei-ichiro Miura, Tomohiro Yamada, Shinji Kamakura a

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2025/08

    DOI： 10.1016/j.ajoms.2025.07.016 　

  4. 抗菌薬投与法の相違による下顎埋伏智歯抜歯術後経過の予備的検討

    江副祐史, 野上晋之介, 冨塚賢弥, 山内健介

    日本化学療法学会雑誌　73　(4)　322-328　2025/07

  5. Clinical and radiographic features of temporomandibular joint in patients with facial asymmetry. International-journal

    Yoshio Otake, Shinnosuke Nogami, Yushi Ezoe, Yuki Sugai, Kyosuke Okuyama, Shizu Saito, Yuri Takeda, Kensuke Yamauchi

    Oral and maxillofacial surgery　29　(1)　98-98　2025/05/10

    DOI： 10.1007/s10006-025-01400-z 　

    More details Close

    PURPOSE: The purpose of this study was to investigate characteristics of mandibular head morphology and temporomandibular joint (TMJ) disorders (TMDs) on the deviation side (DS) and non-deviation side (NDS) in patients with facial asymmetry (FA). METHODS: Thirty patients diagnosed with FA were enrolled. Preoperative and postoperative joint sound and pain were evaluated in terms of clinical symptoms, and pre- and postoperative mandibular head morphology factors shown by computed tomography. In addition, magnetic resonance imaging findings were used to evaluate preoperative joint disc position and joint effusion (JE). RESULTS: The patients included 12 (40.0%) males and 18 (60.0%) females, with a mean age of 25.8 years. There were no significant differences regarding clinical symptoms between patients affected on the DS and those on the NDS. Preoperatively, the DS group showed a total of 4 joints (13.3%) with mandibular condyle head deformity, while postoperatively those patients had 13 (43.3%) and the NDS group 2 (6.7%), indicating a significant difference for condyle head deformity between patients affected on DS and NDS before and after surgery. The score for JE was 1.1 ± 1.0 in the DS group and 0.6 ± 0.8 in the NDS group, a significant difference (P < 0.05). CONCLUSION: As compared to the NDS, the DS in the present class III patients with FA showed a greater number of TMDs, such as condyle head deformity, disc displacement, and JE. It's important for surgeons and orthodontists to be aware of the possibility of TMDs on the DS in class III patients with FA when performing orthognathic surgery.

  6. Clinical course of masticatory function recovery following endoscopic-assisted open reduction and internal fixation in patients with unilateral mandibular condyle fracture. International-journal

    Shinnosuke Nogami, Yushi Ezoe, Yuri Takeda, Yoshio Otake, Hiromitsu Morishima, Kensuke Yamauchi

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery　53　(3)　245-249　2025/03

    DOI： 10.1016/j.jcms.2024.12.005 　

    More details Close

    The purpose of this study was to investigate the clinical course of masticatory function recovery following an endoscopic-assisted open reduction and internal fixation (EAORIF) procedure. Patients with a unilateral mandibular condylar fracture who underwent EAORIF for therapeutic purposes were evaluated, with comparisons made between those who underwent the procedure for base or neck fractures. At each time point analyzed after treatment, the occlusal contact area and maximum bite force in patients with a base fracture were greater, although the differences between the groups were not significant. Moreover, at 12 months following EAORIF for a base fracture, occlusal contact area and maximum bite force on the fractured and non-fractured sides were nearly equal, whereas these were significantly reduced in the fractured as compared with the non-fractured side in patients who underwent that treatment for a neck fracture. Additionally, after 12 months in the neck fracture cases, both occlusal contact area and maximum bite force on the fractured side were lower as compared with those on the non-fractured side. These findings indicate that EAORIF is an optimal method for base fracture treatment with regard to masticatory function.

  7. Clinical course of jaw function recovery following surgical treatment in patients with temporomandibular joint ankylosis – correlation with mouth opening rehabilitation Peer-reviewed

    Yushi Ezoe, Shinnosuke Nogami, Yoshio Otake, Masatoshi Chiba, Tetsu Takahashi, Kensuke Yamauchi

    BMC Oral Health　25　(1)　2025/03

    DOI： 10.1186/s12903-025-05806-9 　

  8. A case of orthognathic surgery for skeletal open bite with Noonan syndrome (NS)

    Kyosuke Okuyama, Shizu Saito, Hikari Suzuki, Yushi Ezoe, Shinnosuke Nogami, Kensuke Yamauchi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2025/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.ajoms.2025.02.002 　

    ISSN： 2212-5558

  9. Relationship of preoperative serum data with MRONJ patient postoperative course – Retrospective study

    Yuri Takeda, Yushi Ezoe, Yuka Iwamae, Tai Kimura, Kenya Tomitsuka, Shinki Koyama, Kazuhiro Imoto, Hiromitsu Morishima, Shinnosuke Nogami, Kensuke Yamauchi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2025

    DOI： 10.1016/j.ajoms.2025.02.006 　

    ISSN： 2212-5558

  10. インプラント周囲に発症した薬剤関連顎骨壊死の4症例

    岩前 有香, 武田 裕利, 服部 雄介, 五十嵐 彩乃, 冨塚 賢弥, 井本 和宏, 江副 祐史, 森島 浩允, 野上 晋之介, 山内 健介

    Japanese Journal of Maxillo Facial Implants　23　(3)　177-177　2024/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

    eISSN： 2433-5509

  11. ナビゲーションシステムを用いた薬剤関連顎骨壊死の外科的治療の1例

    郷家 隆平, 武田 裕利, 岩前 有香, 冨塚 賢弥, 高山 慎騎, 井本 和宏, 森島 浩允, 江副 祐史, 野上 晋之介, 山内 健介

    日本口腔科学会雑誌　73　(3)　277-277　2024/09

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  12. Investigation of periodontal tissue regeneration using octacalcium phosphate and collagen composite

    Keiko Matsui, Shinji Kamakura, Atsumu Kouketsu, Yushi Ezoe, Kei-ichiro Miura, Kensuke Yamauchi

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology　2024/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.ajoms.2024.08.009 　

    ISSN： 2212-5558

  13. 咀嚼筋腱・腱膜過形成症患者に対する下顎角形成術の臨床的検討

    江副 祐史, 野上 晋之介, 互野 亮, 菅井 優生, 高山 慎騎, 五十嵐 彩乃, 大竹 義雄, 千葉 雅俊, 高橋 哲, 山内 健介

    日本顎関節学会雑誌　36　(Suppl.)　139-139　2024/07

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  14. 咀嚼筋腱・腱膜過形成症患者に対する下顎角形成術の臨床的検討

    江副 祐史, 野上 晋之介, 互野 亮, 菅井 優生, 高山 慎騎, 五十嵐 彩乃, 大竹 義雄, 千葉 雅俊, 高橋 哲, 山内 健介

    日本顎関節学会雑誌　36　(Suppl.)　139-139　2024/07

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  15. Temporomandibular joint ankylosis suspected to be associated with ankylosing spondylitis based on cervical computed tomography images: A pictorial essay. International-journal

    Ikuho Kojima, Shinnosuke Nogami, Shin Hitachi, Yusuke Shimada, Yushi Ezoe, Yuka Yokoyama-Sato, Masahiro Iikubo

    Imaging science in dentistry　54　(2)　201-206　2024/06

    DOI： 10.5624/isd.20230243 　

    More details Close

    This report showed a case of temporomandibular joint (TMJ) ankylosis suspected to be associated with ankylosing spondylitis based on the observation of bony ankylosis of the cervical spine on computed tomography (CT) images. A 53-year-old man presented with a chief complaint of difficulty in opening his mouth. His medical history indicated that in his 20s, he became aware of the difficulty in moving his neck. CT revealed marked osteoarthritic changes in the right mandibular condyle, suggesting fibrotic TMJ ankylosis. In addition, bony ankylosis of the cervical vertebral body and facet joints from the axis (C2) to C5 in continuity was observed. CT of the entire spine also showed bony deformity of the sacroiliac joints and bony ankylosis. Based on these findings, ankylosing spondylitis was suspected. The possibility of an ankylosing spondylitis complication should be considered in cases of TMJ ankylosis if bony ankylosis of the cervical spine is observed.

  16. 顎関節滑膜軟骨腫症の臨床・画像所見と併せた病理組織学的検討

    大竹 義雄, 野上 晋之介, 小田島 健二, 江副 祐史, 千葉 雅俊, 山内 健介, 熊本 裕行, 高橋 哲

    日本顎関節学会雑誌　34　(Suppl.)　118-118　2022/07

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  17. Application to open wound extraction socket of new bone regenerative material Peer-reviewed

    Ezoe, Y, Matsui, K, Kouketsu, A, Miura, K, Kamakura, S

    J Oral Maxillofac Surg Med Pathol　2022

  18. Eminectomy for recurrent condylar dislocation with Ehlers-Danlos syndrome : a case report. Peer-reviewed

    Yushi EZOE, Shinnosuke NOGAMI, Shinki KOUYAMA, Hikari SUZUKI, Yoshio OTAKE, Masatoshi CHIBA, Kensuke YAMAUCHI, Tetsu TAKAHASHI

    34　(2)　2022

  19. 当科における顎関節滑膜軟骨腫症の臨床統計

    大竹 義雄, 野上 晋之介, 江副 祐史, 高山 慎騎, 木村 太, 千葉 雅俊, 山内 健介, 高橋 哲

    日本顎関節学会雑誌　33　(Suppl.)　82-82　2021/10

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  20. Ehlers-Danlos症候群患者の習慣性顎関節脱臼に対して関節隆起切除術を施行した1例

    江副 祐史, 野上 晋之介, 菅井 優生, 高山 慎騎, 大竹 義雄, 千葉 雅俊, 山内 健介, 高橋 哲

    日本顎関節学会雑誌　33　(Suppl.)　88-88　2021/10

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  21. 当科における顎関節滑膜軟骨腫症の臨床統計

    大竹 義雄, 野上 晋之介, 江副 祐史, 高山 慎騎, 木村 太, 千葉 雅俊, 山内 健介, 高橋 哲

    日本顎関節学会雑誌　33　(Suppl.)　82-82　2021/10

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  22. Ehlers-Danlos症候群患者の習慣性顎関節脱臼に対して関節隆起切除術を施行した1例

    江副 祐史, 野上 晋之介, 菅井 優生, 高山 慎騎, 大竹 義雄, 千葉 雅俊, 山内 健介, 高橋 哲

    日本顎関節学会雑誌　33　(Suppl.)　88-88　2021/10

    Publisher: (一社)日本顎関節学会

    ISSN： 0915-3004

    eISSN： 1884-4308

  23. Teriparatide with octacalcium phosphate collagen composite stimulates osteogenic factors. International-journal

    Atsumu Kouketsu, Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Tetsu Takahashi, Shinji Kamakura

    Tissue engineering. Part A　28　(3-4)　125-135　2021/07/18

    DOI： 10.1089/ten.TEA.2021.0067 　

    More details Close

    Octacalcium phosphate and collagen composite (OCPcol) promotes osteogenic differentiation and angiogenesis, thereby enhancing bone regeneration. Although a newly developed freeze-dried composite of OCPcol and teriparatide (OCPcolTPTD) reinforced bone regeneration more than OCPcol, the mechanism of bone regeneration remains unresolved. Here, disks containing OCPcolTPTD, OCPcol, or β-tricalcium phosphate (β-TCP) col were inserted into rodents with calvarial bone defects, before euthanasia 4 weeks later. Immunohistochemical and histochemical analyses were performed on bone samples to evaluate bone matrix development, angiogenesis, and osteoclast and osteoblast localization. In the OCPcolTPTD and OCPcol groups, bone regeneration was observed at the surface of calvarial dura mater and around acidophilic granular cells with abundant collagenous fiber-containing cells. Furthermore, the newly formed bone in the OCPcolTPTD group showed a larger total area and individual separated area than the other groups. Various osteogenic proteins were detected in the regenerated bone and peri-bone tissues via histochemistry and immunohistochemistry. Although the expression of several osteogenic biomarkers in the OCPcolTPTD group after 4 weeks of implantation was significantly lower than that in the OCPcol group, new bone formation by OCPcolTPTD in the center of the defect, where bone regeneration is difficult, tended to be superior to that by OCPcol. These results suggest that OCPcolTPTD enhanced bone regeneration more evenly and homogenously than OCPcol.

  24. 当科における骨代謝調節薬投与患者に対する外科処置の臨床的検討

    高山 慎騎, 永井 宏和, 佐藤 舜, 井本 和宏, 森島 浩允, 武田 裕利, 江副 祐史, 高橋 哲

    日本口腔科学会雑誌　70　(2)　152-152　2021/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  25. Segmental Bone Reconstruction by Octacalcium Phosphate Collagen Composites with Teriparatide International-journal

    Keiko Matsui, Tadashi Kawai, Yushi Ezoe, Toshiki Yanagisawa, Tetsu Takahashi, Shinji Kamakura

    Tissue Engineering Part A　27　(9-10)　561-571　2021/05/01

    Publisher: Mary Ann Liebert Inc

    DOI： 10.1089/ten.tea.2020.0150 　

    ISSN： 1937-3341

    eISSN： 1937-335X

    More details Close

    Octacalcium phosphate and collagen composite (OCPcol) demonstrated superior bone regeneration and has been commercialized recently in Japan. Teriparatide (TPTD) is a bioactive recombinant form of parathyroid hormone that is approved for osteoporosis treatment. Because mandibular bone reconstruction after segmental resection is a key clinical problem, it was examined whether single-dose local administration of OCPcol with TPTD can affect recovery after this procedure. OCPcol was prepared, and a commercially available hydroxyapatite and collagen composite (HAPcol) was used as a control. A 15 mm length segmental bone defect was made in the mandibular region of male beagle dogs. The experimental animals were divided in four groups. OCPcol treated with TPTD (OCPcol + TPTD), OCPcol, HAPcol treated with TPTD (HAPcol + TPTD), or HAPcol was implanted into the defect. The radiopaque areas of the implanted site were measured and statistically analyzed, and histological examination was performed after 6 months. The value of radiopaque area in total region of OCPcol + TPTD was highest (90.8 ± 7.3 mm2), followed in order by OCPcol (49.3 ± 21.8 mm2), HAPcol + TPTD (10.6 ± 2.3 mm2), and HAPcol (6.4 ± 2.3 mm2), and that of OCPcol + TPTD was significantly higher than that of HAPcol + TPTD or HAPcol. All segmented mandibles of OCPcol + TPTD and a part of those of OCPcol were bridged with newly formed bone, whereas no bone bridges were observed in HAPcol + TPTD or HAPcol. These results suggested that OCPcol treated with TPTD enabled bone reconstruction after segmental mandibular resection more than other three groups.

  26. Florid Cemento-Osseous Dysplasia-Associated Simple Bone Cyst Showing Marked Irregular Border and High Apparent Diffusion Coefficient Value

    Ikuho K, Takashi N, Maya S, Yuko S, Yushi E, Masahiro I, Hiroyuki K, Tetsu T

    Case Reports in Dentistry　2020　1-7　2020/08/23

    Publisher: Hindawi Limited

    DOI： 10.1155/2020/8854428 　

    ISSN： 2090-6447

    eISSN： 2090-6455

    More details Close

    A simple bone cyst (SBC) is an intrabone cavity without epithelial lining, which occasionally occur with fibrous-osseous lesions. The imaging finding of the scalloped border and conserving the lamina dura, periodontal ligament spaces, or follicular spaces are considered radiographically pathognomonic of SBC. SBC has been reported to occur with fibrous-osseous lesions, including cemento-osseous dysplasia (COD). Computed tomography (CT) imaging findings are sparse, and there are no reports of magnetic resonance imaging (MRI) findings, including apparent diffusion coefficient (ADC) value calculated by diffusion-weighted MRI for the florid COD-associated SBC. We report a case of a 39-year-old woman who was referred to our hospital because a panoramic radiograph of her right mandible showed asymptomatic radiolucency in the apical molar area. CT images showed a low-density lesion in the periapical areas of the right mandible, which accompanied a well-defined, high-density lesion, and a mixed low/high-density lesion with an unusual marked irregular border in the left mandible. The MRI showed cyst-like extremely hyperintense signals on fat-suppressed T2-weighted images at the right mandibular low-density and the left mandibular mixed low/high-density areas. ADC map showed high values (over <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>2.5</mml:mn><mml:mo>×</mml:mo><mml:msup><mml:mrow><mml:mn>10</mml:mn></mml:mrow><mml:mrow><mml:mo>−</mml:mo><mml:mn>3</mml:mn></mml:mrow></mml:msup></mml:math> mm2/s) at the cystic areas in the bilateral mandible. We performed incisional biopsies of the bilateral mandibular lesions and resections of the bilateral maxillary lesions. Surgical and histopathological findings established a diagnosis of florid COD in the bilateral mandible and maxilla, simultaneously complicated by multiple SBCs in the bilateral mandible. The ADC value of cystic component is useful for the diagnosis, if the COD-associated SBC exhibits solitary, nonspecific, or rare imaging findings.

  27. 当科で薬剤性顎骨壊死の発症予防のため抜歯施行した患者の臨床的統計

    江副 祐史, 高山 慎騎, 武田 裕利, 山内 健介, 永井 宏和, 高橋 哲

    日本口腔科学会雑誌　69　(2)　75-75　2020/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  28. 当科で薬剤性顎骨壊死の発症予防のため抜歯施行した患者の臨床的統計

    江副 祐史, 高山 慎騎, 武田 裕利, 山内 健介, 永井 宏和, 高橋 哲

    日本口腔科学会雑誌　69　(2)　75-75　2020/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

  29. Octacalcium phosphate collagen composite stimulates the expression and activity of osteogenic factors to promote bone regeneration

    Kouketsu A, Matsui K, Kawai T, Ezoe Y, Yanagisawa T, Yasuda A, Takahashi T, Kamakura S

    J Tissue Eng Regen Med　14　(1)　99-107　2020/01

    DOI： 10.1002/term.2969 　

    ISSN： 1932-6254

    eISSN： 1932-7005

  30. Teriparatide局所併用OCP/Collagenによるイヌ下顎骨離断部の骨再生

    鎌倉 慎治, 松井 桂子, 川井 忠, 江副 祐史, 柳沢 俊樹, 安田 彩人, 高橋 哲

    日本バイオマテリアル学会大会予稿集　41回　302-302　2019/11

    Publisher: 日本バイオマテリアル学会

  31. Teriparatide局所併用OCP/Collagenによるイヌ下顎骨離断部の骨再生

    鎌倉 慎治, 松井 桂子, 川井 忠, 江副 祐史, 柳沢 俊樹, 安田 彩人, 高橋 哲

    日本バイオマテリアル学会大会予稿集　41回　302-302　2019/11

    Publisher: 日本バイオマテリアル学会

  32. A case of sialadenoma papilliferum in the retromolar mandible Peer-reviewed

    日本口腔外科学会雑誌　65　(3)　179-183　2019/03

    Publisher:

    ISSN： 0021-5163

  33. 化学療法開始前に周術期口腔管理を行った患者の歯周病と糖尿病を含めた生活習慣病との関連の検討

    江副 祐史, 高橋 かおり, 神田 直典, 高橋 哲, 熊谷 正浩

    有病者歯科医療　27　(6)　507-508　2018/12

    Publisher: (一社)日本有病者歯科医療学会

    ISSN： 0918-8150

    eISSN： 1884-667X

  34. Application of Octacalcium Phosphate Collagen Composite to Bone Defects in Humans: A Long-Term Observational Study

    Tadashi Kawai, Tetsu Takahashi, Keiko Matsui, Yushi Ezoe, Osamu Suzuki, Shinji Kamakura

    Clinis in Surgery　3　2018/09/18

  35. Application of octacalcium phosphate collagen composite for dental implant treatment

    17　(1)　3-8　2018/04/25

    Publisher:

    ISSN： 1347-894X

  36. Efficacy of octacalcium phosphate collagen composite for titanium dental implants.

    Tadashi Kawai, Keiko Matsui, Yushi Ezoe, Fumihiko Kajii, Osamu Suzuki Tetsu Takahashi, Shinji Kamakura

    Materials　11　(2)　2018/02

  37. Application of Octacalcium Phosphate and Collagen Composite for Bone Augmentation with Sinus Floor Elevation in Humans. Peer-reviewed

    Kawai T, Takahashi T, Matsui K, Ezoe Y, Kajii F, Shimizu Y, Koyama S, Kumamoto H, Suzuki O, Kamakura S

    Clinics in Surgery　3　1-6　2018

    ISSN： 0198-7569

    eISSN： 1945-3388

  38. 上顎洞底挙上術へのリン酸オクタカルシウム・コラーゲン複合体の応用

    江副 祐史, 川井 忠, 松井 桂子, 梶井 文彦, 清水 良夫, 小山 重人, 熊本 裕行, 鎌倉 慎治, 高橋 哲

    Japanese Journal of Maxillo Facial Implants　16　(3)　175-175　2017/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

  39. Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal® FS system, and polyglycolic acid sheets as wound coverings after oral surgery. International-journal

    Atsumu Kouketsu, Shinnosuke Nogami, Minami Yamada-Fujiwara, Hirokazu Nagai, Kensuke Yamauchi, Shiro Mori, Hitoshi Miyashita, Tadashi Kawai, Aritsune Matsui, Yoshihiro Kataoka, Norihisa Satomi, Yushi Ezoe, Satoko Abe, Yuri Takeda, Takeshi Tone, Bunnichi Hirayama, Tsuyoshi Kurobane, Kazuki Tashiro, Yuta Yanagisawa, Tetsu Takahashi

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery　45　(9)　1458-1463　2017/09

    DOI： 10.1016/j.jcms.2017.06.004 　

    More details Close

    The CryoSeal® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques.

  40. 乳癌骨転移症例におけるBRONJ予防目的の観血的歯科処置の検討

    神田 直典, 江副 祐史, 高橋 哲, 熊谷 正浩

    東北大学歯学雑誌　35/36　(2/1)　70-75　2017/06

    Publisher: 東北大学歯学会

    ISSN： 0287-3915

  41. リン酸オクタカルシウム・コラーゲン複合体とインプラント体との親和性評価

    川井 忠, 松井 桂子, 江副 祐史, 梶井 文彦, 鈴木 治, 高橋 哲, 鎌倉 慎治

    Japanese Journal of Maxillo Facial Implants　15　(3)　148-148　2016/11

    Publisher: (公社)日本顎顔面インプラント学会

    ISSN： 1347-894X

  42. Orthotopic Osteogenecity Enhanced by a Porous Gelatin Sponge in a Critical-Sized Rat Calvaria Defect International-journal

    Kanda N, Anada T, Handa T, Kobayashi K, Ezoe Y, Takahashi T, Suzuki O

    Macromol. Biosci.　15　(12)　1647-1655　2015/12

    DOI： 10.1002/mabi.201500191 　

    More details Close

    The gelatin (Gel) powders, derived from acidic and basic extractions of porcine dermis (referred to as AE and BE), were processed for the porous sponge preparation. The disks, which were less than or greater than 500 μm in diameter [small (S) and large (L) pores, respectively] in both extractions and had an interconnected structure respectively, were implanted in critical-sized defects (CSD) of rat calvaria for 4 and 8 weeks to analyze the bone repair capability. Only the AE-S disk induced bone formation (over 60%) histomorphometrically in the CSD after 8 weeks, although the collagen orientation of the regenerated bone was still immature. Osteoblastic cell culture until 14 days did not substantiate marked superiority of AE-S disk regarding the proliferation and the differentiation, although the initial attachment was enhanced on AE-S disk than BE-L disk. The results provide the findings that a Gel sponge with a specific porous structure is capable of inducing orthotopic bone formation in vivo environment.

  43. リン酸オクタカルシウム・コラーゲン複合体のイヌ抜歯窩socket preservationへの応用による骨再生能の評価

    江副 祐史, 松井 桂子, 川井 忠, 高橋 哲

    日本口腔インプラント学会誌　28　(特別号)　276-276　2015/08

    Publisher: (公社)日本口腔インプラント学会

    ISSN： 0914-6695

    eISSN： 2187-9117

  44. リン酸オクタカルシウム・コラーゲン複合体の抜歯窩への応用

    松井 桂子, 鎌倉 慎治, 江副 祐史, 川井 忠, 高橋 哲

    日本口腔科学会雑誌　64　(2)　199-200　2015/07

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  45. Characterization of partially hydrolyzed OCP crystals deposited in a gelatin matrix as a scaffold for bone tissue engineering.

    Ezoe Y, Anada T, Yamazaki H, Handa T, Kobayashi K, Takahashi T, Suzuki O

    Journal of Nanoparticle Reseach　17　(3)　2015/03

    DOI： 10.1007/s11051-015-2864-1 　

    ISSN： 1388-0764

    eISSN： 1572-896X

  46. The role of an octacalcium phosphate in the reformation of infraspinatus tendon insertion. International-journal

    Itoigawa Y, Suzuki O, Sano H, Anada T, Handa T, Hatta T, Kuwahara Y, Takahashi A, Ezoe Y, Kaneko K, Itoi E

    J Shoulder Elbow Surg　24　(7)　175-184　2015

    DOI： 10.1016/j.jse.2015.01.011 　

    More details Close

    BACKGROUND: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. METHODS: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. RESULTS: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P < .05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. CONCLUSION: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

  47. リン酸オクタカルシウム・コラーゲン複合体の適正規格の検討

    松井 桂子, 鎌倉 慎治, 川井 忠, 江副 祐史, 田沼 裕志, 鈴木 治, 越後 成志, 高橋 哲

    日本口腔科学会雑誌　63　(4)　446-446　2014/09

    Publisher: (NPO)日本口腔科学会

    ISSN： 0029-0297

    eISSN： 2185-0461

  48. 棘下筋腱付着部再生におけるoctacalcium phosphate(OCP)ゼラチン複合体の役割

    糸魚川 善昭, 鈴木 治, 佐野 博高, 穴田 貴久, 半田 拓人, 八田 卓久, 桑原 功行, 高橋 敦, 江副 祐史, 金子 和夫, 井樋 栄二

    日本整形外科学会雑誌　88　(8)　S1628-S1628　2014/08

    Publisher: (公社)日本整形外科学会

    ISSN： 0021-5325

  49. リン酸オクタカルシウム・ゼラチン複合体の加水分解における結晶相の変化

    江副 祐史, 穴田 貴久, 半田 拓人, 高橋 哲, 鈴木 治

    日本歯科理工学会誌　32　(2)　82-82　2013/03

    Publisher: (一社)日本歯科理工学会

    ISSN： 1884-4421

Show all ︎Show first 5

Misc. 5

  1. ナビゲーションシステムを用いた薬剤関連顎骨壊死の外科的治療の1症例

    郷家隆平, 武田裕利, 岩前有香, 冨塚賢弥, 高山慎騎, 井本和宏, 森島浩允, 江副祐史, 野上晋之介, 山内健介

    日本口腔科学会雑誌(Web)　73　(3)　2024

    ISSN： 2185-0461

  2. 当科における変形性顎関節症に関する臨床的検討

    高山慎騎, 江副祐史, 五十嵐彩乃, 菅井優生, 野上晋之介, 千葉雅俊, 千葉雅俊, 山内健介

    日本顎関節学会雑誌(Web)　36　2024

    ISSN： 1884-4308

  3. 咀嚼筋腱・腱膜過形成症患者に対する下顎角形成術の臨床的検討

    江副祐史, 野上晋之介, 互野亮, 菅井優生, 高山慎騎, 五十嵐彩乃, 大竹義雄, 千葉雅俊, 高橋哲, 山内健介

    日本顎関節学会雑誌(Web)　36　2024

    ISSN： 1884-4308

  4. Eminectomy for Recurrent temporomandibular joint dislocation with Ehlers-Danlos syndrome: A case report

    江副祐史, 野上晋之介, 菅井優生, 高山慎騎, 大竹義雄, 千葉雅俊, 山内健介, 高橋哲

    日本顎関節学会雑誌(Web)　33　2021

    ISSN： 1884-4308

  5. P-52 Preparation of partially hydrolyzed octacalcium phosphate/gelatin composites and their cellular response

    Ezoe Y, Anada T, Kobayashi K, Handa T, Takahashi T, Suzuki O

    The journal of the Japanese Society for Dental Materials and Devices　34　(2)　140-140　2015/03/25

    Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)

    ISSN： 1884-4421

    More details Close

    We have previously shown that partially hydrolyzed octacalcium phosphate (OCP) has a better osteoconductivity more than that of the original OCP. This study was designed to investigate the effect of the presence of gelatin molecules on the hydrolysis reaction of OCP and the biological characteristics of OCP-co-precipitated gelatin composite (OCP/Gel) by partially hydrolysis reaction. The results showed that hydrolysis of OCP in OCP/Gel tended to advance more than the absence of Gel molecules in the hydrolysis reaction and the hydrolyzed OCP/Gel showed similar biocompatibility as the Gel alone.

Presentations 22

  1. The effect of prophylactic antibiotic administration periods on orthognathic surgery site infections: A prospective randomized controlled trial.

    2025/11/15

  2. 当科における外傷性三叉神経障害性疼痛に対する薬物療法効果の検討

    江副祐史, 高山慎騎, 野上晋之介, 千葉雅俊, 山内健介

    第28回口腔顔面神経機能学会総会・学術大会　2025/03/01

  3. 当科における口腔灼熱症候群、三叉神経痛患者の破局的思考および生活障害度の検討

    江副祐史, 高山慎騎, 矢崎麻衣, 千葉雅俊

    第29回日本口腔顔面痛学会学術大会　2024/12/01

  4. 咀嚼筋腱・腱膜過形成症患者に対する下顎角形成術の臨床的検討

    江副祐史, 野上晋之介, 菅井優生, 高山慎騎, 五十嵐彩乃, 大竹義雄, 千葉雅俊, 髙橋 哲, 山内健介

    第37回日本顎関節学会学術大会　2024/07/13

  5. 下顎埋伏智歯抜歯における単回と複数回の抗菌薬予防投与：前向きランダム化臨床研究

    江副祐史, 冨塚賢弥, 岡本大悟, 宮下 仁, 野上晋之介, 山内健介

    第68回(公社)日本口腔外科学会総会・学術大会　2023/11/11

  6. Single vs multiple doses of prophylactic antibiotics in extraction of impacted mandibular third molars: A prospective randomized controlled trial.

    Ezoe Y, Tomitsuka K, Okamoto D, MIyashita H, Nogami S, Yamauchi K

    The 64th Annual Congress of Korean Association of Oral and Maxillofacial Surgeons　2023/04/22

  7. Ehlers-Danlos症候群患者の習慣性顎関節脱臼に対して関節隆起切除術を施行した1例

    江副祐史, 野上晋之介, 菅井優生, 高山慎騎, 大竹義雄, 千葉雅俊, 山内健介, 髙橋 哲

    第34回日本顎関節学会学術大会　2021/10

  8. 当科における顎関節強直症に対する外科的治療と その治療成績

    江副祐史, 野上晋之介, 菅井優生, 高山慎騎, 大竹義雄, 千葉雅俊, 山内健介, 髙橋 哲

    第66回日本口腔外科学会総会・学術集会　2021/11

  9. 当科で薬剤性顎骨壊死の発症予防のため抜歯施行した患者の臨床的検討

    江副祐史, 高山慎騎, 井本和宏, 森島浩允, 武田裕利, 山内健介, 永井宏和, 髙橋哲

    第46回日本口腔外科学会 北日本支部学術集会　2020/11

  10. 当科にて薬剤性顎骨壊死の発症予防目的に抜歯施行した患者の術後の臨床的検討

    江副祐史, 井本和宏, 鈴木飛佳理, 大泉丈史, 山内健介, 永井宏和, 髙橋哲

    第45回日本口腔外科学会 北日本支部学術集会　2019/05

  11. オクタカルシウムフォスフェート・コラーゲン複合体 のsocket preservationへの適用における骨再生能の評価

    江副祐史, 松井桂子, 川井忠, 高橋哲, 鎌倉慎治

    第18回日本再生医療学会総会　2019/03

  12. Clinical evaluation of correlation between diabetes and periodontal status in a group of breast cancer patients before chemotherapy.

    Yushi EZOE, Kaori TAKAHASHI, Naofumi KANDA, Tetsu TAKAHASHI, Masahiro KUMAGAI

    13th Asian congress of Oral & Maxillofacial Surgery　2018/11

  13. 化学療法開始前に周術期口腔管理を行った患者の 歯周病と糖尿病の関連性の統計学的検討

    江副祐史, 高橋かおり, 神田直典, 高橋哲, 熊谷正浩

    第27回日本有病者歯科医療学会総会・学術大会　2018/03

  14. 上顎洞底挙上術へのリン酸オクタカルシウム・コラーゲン複合体の応用

    江副祐史, 川井忠, 松井桂子, 梶井文彦, 清水良央, 小山重人, 熊本裕行, 鈴木治, 鎌倉慎治, 髙橋 哲

    第21回日本顎顔面インプラント学会総会・学術大会　2017/12

  15. ラット頭蓋冠臨界骨欠損における多孔性ゼラチンスポンジの骨再生能について

    江副祐史, 神田直典, 穴田貴久, 塩飽由香里, 小林司史, 高橋哲, 鈴木治

    第37回日本バイオマテリアル学会大会　2015/11

  16. リン酸オクタカルシウム・コラーゲン複合体のSocket preservationへの応用

    江副祐史, 松井, 桂子, 川井忠, 髙橋哲, 鎌倉慎治

    第60回日本口腔外科学会総会・学術大会　2015/10

  17. リン酸オクタカルシウム・コラーゲン複合体のイヌ抜歯窩socket preservationへの応用による骨再生能の評価

    江副祐史, 松井桂子, 川井忠, 髙橋哲

    第45回日本口腔インプラント学会学術大会　2015/09

  18. 加水分解処理されたリン酸オクタカルシウム(OCP)析出ゼラチン複合担体の生体材料学的評価

    江副祐史, 穴田 貴久, 山崎元, 半田拓人, 小林司史, 高橋哲, 鈴木治

    第14回日本再生医療学会総会　2015/03/21

  19. リン酸オクタカルシウム・コラーゲン複合体のイヌ抜歯窩開放創への埋入による骨再生能の評価

    江副祐史, 松井 桂子, 川井忠, 鈴木治, 高橋哲, 鎌倉慎治

    第14回日本再生医療学会総会　2015/03/21

  20. Characteristics and biocompatibility of octacalcium phosphate/gelatin (OCP/Gel) composites subjected by hydrolysis

    Y.Ezoe, T.Handa, T.Anada, T.Takahashi, O.Suzuki

    8th International Workshop on Biomaterials in Interface Science　2013/08/30

  21. Structural change of crystal phase of octacalcium phosphate co-precipitated gelatin composite by hydrolysis reaction-

    2013/04/13

  22. 高用量注射骨吸収抑制薬投与患者の抜歯後の顎骨壊死発症に関する観察研究

    江副 祐史, 佐藤 舜, 高山 慎騎, 井本 和宏, 森島 浩允, 三浦 圭一郎, 武田 裕利, 山内 健介, 永井 宏和, 髙橋 哲

    第47回日本口腔外科学会北日本支部学術集会　2021/05/15

Show all Show first 5

Research Projects 3

  1. リン酸八カルシウム・コラーゲン複合体と自家骨とによる広範囲顎骨再建法の確立

    川井 忠, 松井 桂子, 江副 祐史, 鈴木 治, 鎌倉 慎治, 山田 浩之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 岩手医科大学

    2021/04/01 - 2024/03/31

    More details Close

    ２０２１年度はリン酸八カルシウム・コラーゲン複合体のみをイヌ下顎骨区域切除部位に埋入する手術と、腸骨から採取した自家骨とリン酸八カルシウム・コラーゲン複合体を混合させて埋入する手術を行う計画であった。リン酸八カルシウム・コラーゲン複合体（商品名Bonarc）の販売予定が遅れており、２０２１年度中での購入ができなかった。購入が今後も遅れる場合は、製造元の東洋紡株式会社に大学との共同研究の申請を依頼し、材料の供給を確保することを考えている。イヌを用いた実験内容で岩手医科大学動物実験計画書を申請したが、これまでの経験からイヌでの実験はかなりの労力を費やすことから、現在では手術に伴う時間や人員などの削減のため、同じ中型動物であるウサギの下顎骨を用いた同内容での実験の検討を行っている。今後はウサギでも同内容の実験が可能かを確認しつつBonarcの供給を待つ予定である。当初の予定通りイヌで進める場合は、現在は予定より遅れているため、スムーズに実験を進めるために、これまでイヌでの実験多く進めてきた東北大学の動物実験施設で行うことも検討している。実験の準備としては、下顎骨の区域切除術に使用する医療用器機を購入した。人員も申請した分担者以外にも、当分野の大学院生を数人確保し、研究を行う準備は進めている。また今後の研究へのためにも様々な学会へ参加し、顎骨再建に関わる材料や手法についての演題や講演から研究に参考となる情報を収集した。

  2. リン酸八カルシウム・コラーゲン複合体再生骨の生理的環境下への適応

    松井 桂子, 鎌倉 慎治, 江副 祐史

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2024/03/31

    More details Close

    本研究グループにおいて系統的に中型動物による各種トランスレーショナル実験を行い、ヒト臨床においてはすでに骨再生材料として企業主導の臨床治験が終了し、2019年5月に厚生労働省より商品化が承認されているリン酸八（オクタ）カルシウム（octacalcium phosphate；OCP）とブタ皮膚由来のアテロコラーゲンを複合化したOCP/Collagen 複合体（OCP/Col：商品名Bonarc）は、口腔外科領域の顎骨欠損部における骨再生が充分に実証されている。一方で、口腔外科の臨床上、顎骨の腫瘍や嚢胞などの摘出後は大小サイズの骨欠損部となるが、同部に隣在する骨支持を失った天然歯は、動揺著しく抜去を余儀なくされることが多く見受けられる。それは患者の咬合形態の崩壊を招き、QOLを著しく低下させることとなる。 そこで本研究では顎骨の病巣摘出と同時に埋入したOCP/Colにより歯根周囲に形成された骨組織が、顎骨欠損に隣接する残存歯を抜去することなく保存可能となるか、再生骨と天然歯根の親和性を確認するために立案された。 今年度は、ビーグル犬を使用し、下顎前臼歯部歯根周囲の骨欠損部へOCP/Col埋入実験を行った。実験の内容は、ビーグル犬の左側下顎骨下縁下方部にて外側皮膚を切開し、鈍的に軟組織を剥離、下顎骨下縁部から口腔内で前臼歯部辺縁歯肉歯槽頂縁から約５mm下方、付着歯肉の下底部の高さまで下顎骨を露出させ、下顎第３・４前臼歯歯根の側面部を露出、または一部削除するように、３mm×20mmの帯状に人工的骨欠損を作製した。同骨欠部にOCP/Colを埋入し３か月間の経過観察を行った。観察期間終了後に下顎骨の標本を摘出し、X線学的に歯根表面における骨再生状況について検討した。

  3. The short/long-term effects on hemostasis and bone regeneration of octacalcium phosphate collagen composites

    MATSUI KEIKO, KAMAKURA Shinji, TAKAHASHI Tetsu, KAWAI Tadashi, EZOE Yushi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2016/03/31

    More details Close

    The octacalcium phosphate collagen composites (OCP/Col) of a bone regeneration material were applied to tooth extraction sockets. We examined how to use OCP/Col as a hemostatic material, and the regenerative bone was investigated with regard to maintenance of the alveolar ridge after healing of extraction sockets. After canine mandibular premolars were extracted, OCP/Col disks were implanted into the sockets. One side was completely closed with a mucoperiosteal flap, while the other was left as an open wound. Three months later, equivalent healing was observed on both sides. However, the buccolingual width of the open wound tended to be larger. Intraoral findings were not remarkable. Therefore, OCP/Col can be used in extraction sockets as a hemostatic material, and the regenerative bone effectively maintains the alveolar ridge. OCP/Col may thus be applicable to socket preservation.