Details of the Researcher

PHOTO

Mizuki Hino
Section
International Research Institute of Disaster Science
Job title
Specially Appointed Assistant Professor(Research)
Degree
e-Rad No.
80396663

Professional Memberships 3

  • 日本生物学的精神医学会

    2022/04 - Present

  • 日本分子生物学会

  • 日本細胞生物学会

Research Interests 6

  • disaster psychiatry

  • tubulin

  • ブレインバンク

  • 精神疾患

  • 包括脳ネットワーク

  • 死後脳

Research Areas 3

  • Life sciences / Biophysics /

  • Life sciences / Neuroanatomy and physiology /

  • Life sciences / Morphology, anatomy /

Papers 65

  1. Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study

    Changrong Duan, Zhiqian Yu, Xue Li, Mai Sakai, Yuko Maejima, Kenju Shimomura, Tomoyuki Furuyashiki, Saya Kikuchi, Natsuko Kobayashi, Kazuto Sasaki, Tasuku Matsuki, Hiroshi Komatsu, Mizuki Hino, Yasuto Kunii, Tomoko Kasahara, Mami Ishikuro, Keiko Murakami, Masatsugu Orui, Takaaki Abe, Fuji Nagami, Nobuo Fuse, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Naoki Nakaya, Atsushi Hozawa, Taku Obara, Shinichi Kuriyama, Hiroaki Tomita

    Molecular Psychiatry　2026/02/04

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41380-026-03456-z 　

    ISSN： 1359-4184

    eISSN： 1476-5578

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    Abstract Maternal perinatal depression (MPD) is associated with reduced maternal plasma oxytocin (OXT) levels and an increased risk of autism spectrum disorder (ASD) in offspring. Using data from 23,218 Japanese mother–child pairs, we evaluated the relationship between MPD—assessed with the Kessler Psychological Distress Scale (K6) and the Edinburgh Postnatal Depression Scale (EPDS)—and autistic-related traits (ART) in toddlers, measured by the Tokyo Autistic Behavior Scale (TABS). We also tested the potential causal relationship of maternal stress exposure on OXT, its receptor (OXTR), and offspring outcomes using a prenatal stress-exposed mouse model. In the human cohort study, higher K6 or EPDS scores during pregnancy and postpartum were significantly associated with increased TABS scores in toddlers. Offspring of mothers with MPD (K6 or EPDS score ≥ 9) during pregnancy or postpartum exhibited a higher risk of ART (TABS score ≥ 15; P  < 0.05). This risk was particularly pronounced in female toddlers exposed to MPD during pregnancy and postpartum (ORs: 5.805–9.367; P  < 0.05). Female toddlers born to mothers with MPD also had lower birth weight, and their ART were positively correlated with K6 scores during mid-gestation and with impaired maternal bonding postpartum. In the mouse model, chronically stressed dams displayed depressive-like behaviors, and their female juveniles exhibited increased self-grooming and impaired social interaction. Furthermore, OXTR mRNA levels were significantly reduced in the prefrontal cortex of female juveniles from stressed dams. These findings suggest that MPD increases the risk of ART, particularly in females, highlighting potential sex-specific mechanisms underlying ASD susceptibility.

  2. Short- and long-term associations between antipsychotic treatment patterns and functional outcomes in chronic schizophrenia: A 10-year retrospective study using lagged mixed-effects modeling. International-journal

    Yuhei Mori, Risa Shishido, Mizuki Hino, Akiko Sato, Atsuko Nagaoka, Hiroshi Hoshino, Masataka Hatano, Yuto Hosogai, Yasuto Kunii, Itaru Miura

    Journal of psychiatric research　193　140-148　2026/02

    DOI： 10.1016/j.jpsychires.2025.11.020 　

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    BACKGROUND: The longitudinal relationship between antipsychotic treatment patterns, such as polypharmacy and use of long-acting injectable (LAI) antipsychotics, and real-world functional outcomes is insufficiently explored. METHODS: We conducted a single-center 10-year retrospective study including 114 patients with chronic schizophrenia. Monthly Global Assessment of Functioning (GAF) scores were assessed (>122 months), alongside antipsychotic patterns [polypharmacy, LAI, and chlorpromazine-equivalent (CPeq)]. A lagged linear mixed-effects model tested whether prior-month treatment predicted next-month GAF. Ordinary least squares regression assessed cumulative exposure with final GAF and 10-year change. Subgroup analyses were stratified by duration of untreated psychosis (DUP). RESULTS: Subsequent GAF scores showed significant positive associations with 1-month lagged polypharmacy (estimate = +1.50, standard error (SE) = 0.14, p < .001) and 1-month lagged use of LAI (estimate = +1.89, SE = 0.27, p < .001), and a significant negative association with lagged CPeq dosage (estimate = 3.7 × 10-3, SE = 1.8 × 10-4, p < .001). Hospitalizations were negatively associated with functional outcome (β = -0.24, p = .038). Cumulative polypharmacy, use of LAIs, and CPeq dose were not significantly associated with either final GAF or 10-year GAF change. Using stratified analyses by DUP, all models showed no statistically significant results; however, educational level and number of hospitalizations modulated long-term functional outcomes in the DUP <12 months group. CONCLUSION: Short-term GAF improvement was linked to polypharmacy and use of LAI, whereas higher doses predicted poorer functioning. DUP-based subgroup models showed no significant results overall.

  3. Calculation of approximate heart rate variability indicators based on low-resolution heart rate data provided by widely used commercially available wearable devices.

    Xue Li, Goh Onoguchi, Hiroshi Komatsu, Chiaki Ono, Noriko Warita, Zhiqian Yu, Atsuko Nagaoka, Sho Horikoshi, Kenji Iwabuchi, Kohei Fuji, Mizuki Hino, Yuta Takahashi, Hisashi Ohseto, Natsuko Kobayashi, Saya Kikuchi, Yasuto Kunii, Taku Obara, Shinichi Kuriyama, Noriyasu Homma, Parashkev Nachev, Akinori Ito, Hiroaki Tomita

    Biomedical Signal Processing and Control　112　108579-108579　2026

    DOI： 10.1016/j.bspc.2025.108579 　

  4. Mosaic variants of neurodevelopmental and mitochondrial genes in postmortem paraventricular thalamus in bipolar disorder detected by deep exome sequencing. International-journal

    Masaki Nishioka, Zen-Ichi Tanei, Yuko Saito, Maho Morishima, Mizuki Hino, Kanako Mori, Atsuko Nagaoka, Risa Shishido, Rie Saito, Hideaki Kitamura, Akito Nagakura, Araki Kimura, Shuji Iritani, Kenichi Oshima, Akiyoshi Kakita, Yasuto Kunii, Shigeo Murayama, Tadafumi Kato

    Psychiatry and clinical neurosciences　79　(10)　653-666　2025/10

    DOI： 10.1111/pcn.13871 　

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    AIM: The genetic architecture of bipolar disorder (BD) remains incompletely understood despite extensive genomic studies. Postzygotic mosaic variants have emerged as promising contributors to BD; however, the landscape of such variants in the BD brain has yet to be elucidated. METHODS: We analyzed mosaic variants in the paraventricular thalamic region (PVR) from 18 Japanese BD cases and 11 controls using deep whole-exome sequencing. Candidate variants were validated via targeted amplicon sequencing. To explore their biological implications, we performed gene ontology analysis by integrating the brain-derived mosaic variants identified in this study with mosaic variants previously detected in peripheral tissues. RESULTS: We identified 99 exonic and 13 mitochondrial heteroplasmic variants in the PVR. There was a significant enrichment of deleterious mosaic variants in constrained genes (P = 0.0402) and of non-synonymous mosaic variants in neurodevelopmental genes, particularly those involved in the positive regulation of neuron projection development (false discovery rate = 2.32 × 10-3). These genes also formed a significantly enriched protein-protein interaction network (P = 0.0106). Notably, we detected one mitochondrial variant known to be pathogenic for mitochondrial disease and two predicted pathogenic mitochondrial tRNA variants in BD cases, but none in controls. CONCLUSION: Despite the modest sample size and potential confounding factors such as age and cancer status, our direct analysis of brain tissue supports previous findings of an enrichment of mosaic variants in neurodevelopmental and mitochondrial tRNA genes. These results advance our understanding of the genetic underpinnings of BD.

  5. Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls. International-journal

    Masataka Hatano, Atsuko Nagaoka, Kazusa Miyahara, Yuto Hosogai, Risa Shishido, Hideomi Hamasaki, Mizuki Hino, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii, Itaru Miura

    Neuropsychopharmacology reports　45　(3)　e70053　2025/09

    DOI： 10.1002/npr2.70053 　

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    Controlling for confounding factors in postmortem brain studies of psychiatric disorders is crucial, particularly in gene expression analyses. Potential confounding factors include sex, age at death, medication history, agonal state, postmortem interval (PMI), tissue storage duration, tissue pH, and RNA integrity number (RIN). pH and RIN are considered particularly important in gene expression analysis because they accurately reflect mRNA quality. We previously found that pH and RIN affected the levels of genes related to the cell cycle and RNA processing, respectively, and both affected genes involved in energy production and the immune system. In this study, we investigated the influence of confounding factors on gene expression profiles in psychiatric disorders. We measured gene expression levels in the prefrontal cortex of 25 deceased patients with schizophrenia, 10 with bipolar disorder, and 21 nonpsychiatric controls via RNA sequencing, and identified genes associated with pH, RIN, PMI, sex, age at death, tissue storage duration, and antipsychotic drug dose. We identified key molecular pathways through Ingenuity Pathway Analysis. The total number of mRNA variants significantly correlated with gene expression, and each confounding factor was as follows: 139 for sex, 87 for age, 99 for PMI, 35 386 for pH, 11 373 for RIN, and 13 414 for storage duration. We identified strong associations with metabolic, immune, energy production, and DNA repair pathways. The expression of certain genes was strongly associated with different confounding factors; therefore, it is necessary to consider these factors when interpreting the gene expression profile in brain tissue.

  6. Response to [Reevaluating Antipsychotic Polypharmacy in Schizophrenia: A Broader Perspective on Social Recovery]. International-journal

    Yuhei Mori, Risa Shishido, Mizuki Hino, Akiko Sato, Atsuko Nagaoka, Hiroshi Hoshino, Masataka Hatano, Yuto Hosogai, Itaru Miura, Yasuto Kunii

    Psychiatry and clinical neurosciences　79　(7)　430-431　2025/07

    DOI： 10.1111/pcn.13834 　

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    This article relates to Reevaluating Antipsychotic Polypharmacy in Schizophrenia: A Broader Perspective on Social Recovery.

  7. Long-term outcomes of schizophrenia in relation to course of social recovery and prescribed antipsychotics: A 10-year follow-up study at a single university hospital in Japan. International-journal

    Yuhei Mori, Risa Shishido, Mizuki Hino, Akiko Sato, Atsuko Nagaoka, Hiroshi Hoshino, Masataka Hatano, Yuto Hosogai, Itaru Miura, Yasuto Kunii

    Psychiatry and clinical neurosciences　79　(4)　205-207　2025/04

    DOI： 10.1111/pcn.13803 　

  8. Mental health needs in the acute and subacute phases of the 2024 Noto Peninsula earthquake: Emergency Medical Information System data analysis in Disaster Psychiatric Assistance Team activities. International-journal

    Yasuto Kunii, Yumiko Hamaie, Mizuki Hino, Yusuke Utsumi, Yasuhisa Fukuo, Hiroaki Tomita

    PCN reports : psychiatry and clinical neurosciences　4　(1)　e70085　2025/03

    DOI： 10.1002/pcn5.70085 　

    ISSN： 2769-2558

  9. Experimenters' sex modulates anxiety-like behavior, contextual fear, and microglial oxytocin transcription in mice International-journal

    Mai Sakai, Zhiqian Yu, Rosanne Picotin, Tomoko Kasahara, Yoshie Kikuchi, Chiaki Ono, Mizuki Hino, Yasuto Kunii, Yuko Maejima, Kenju Shimomura, Miharu Nakanishi, Takaaki Abe, Hatsumi Yoshii, Hiroaki Tomita

    Behavioural Brain Research　483　115480-115480　2025/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.bbr.2025.115480 　

    ISSN： 0166-4328

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    Oxytocin (OXT) is a neuropeptide known for modulating anxiety and fear memory. We have reported that microglial cytokine regulates contextual fear memory and that microglial OXT positively correlates with cytokine secretion. However, the relationship between contextual fear memory and microglial OXT expression remains unclear. We evaluated whether experimental handling minimizes anxiety-like behaviors through microglial OXT expression and its effects on contextual fear response in a sex-dependent manner. Male and female mice were cup-handled for seven days by male or female experimenters (four groups: male mice with or without handling and female mice with or without handling). Post-handling anxiety-like behavior was assessed using elevated plus maze (EPM) and light-dark box (LDB) tests. Microglial Oxt transcription was evaluated using real-time PCR following handling and footshock. Our results showed that handling by female experimenters induced anxiolytic behaviors in the EPM and LDB and microglial Oxt transcripts in male mice but did not show a direct causal relationship. After handling by male experimenters, male mice exhibited stronger conditional freezing responses than female mice. In contrast, female mice exhibited significantly weaker freezing, independent of Oxt transcription in the microglia and the paraventricular hypothalamic nucleus. These findings suggest that handling influences anxiety and microglial Oxt expression, while conditional freezing reflects a sex-dependent effect by experimenter sex.

  10. Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia

    Julio Leon, Satoshi Yoshinaga, Mizuki Hino, Atsuko Nagaoka, Yoshinari Ando, Jonathan Moody, Miki Kojima, Ayako Kitazawa, Kanehiro Hayashi, Kazunori Nakajima, Carlo Condello, Piero Carninci, Yasuto Kunii, Chung Chau Hon, Jay W. Shin, Ken-ichiro Kubo

    2024/06/28

    Publisher: Cold Spring Harbor Laboratory

    DOI： 10.1101/2024.06.27.601103 　

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    Abstract Schizophrenia is one of the most prevalent psychiatric disorders with unclear pathophysiology despite a century-long history of intense research. Schizophrenia affects multiple networks across different brain regions. The anterior cingulate cortex (ACC) is the region that connects the limbic system to cognitive areas such as the prefrontal cortex and represents a pivotal region for the etiology of schizophrenia; however, the molecular pathology, considering its cellular and anatomical complexity, is not well understood. Here, we performed an integrative analysis of spatial and single-nucleus transcriptomics of the postmortem ACC of people with schizophrenia, together with a thorough histological analysis. The data revealed major transcriptomics signatures altered in schizophrenia, pointing at the dysregulation of glial cells, primarily in astrocytes. We further discovered a decrease in the cellular density and abundance of processes of interlaminar astrocytes, a subpopulation of astrocytes specific to primates that localize in the layer 1 and influence the superficial cortical microenvironment across layer 1 and layers 2/3 of the cortex. Our study suggests that aberrant changes in interlaminar astrocytes could explain the cell-to-cell circuit alterations found in schizophrenia and represent novel therapeutic targets to ameliorate schizophrenia-associated dysfunction.

  11. Availability of individual proteins for quantitative analysis in postmortem brains preserved in two different brain banks International-journal

    Atsuko Nagaoka, Mizuki Hino, Ryuta Izumi, Risa Shishido, Miki Ishibashi, Masataka Hatano, Makoto Sainouchi, Akiyoshi Kakita, Hiroaki Tomita, Yasuto Kunii

    Neuropsychopharmacology Reports　44　(2)　399-409　2024/04

    Publisher: Wiley

    DOI： 10.1002/npr2.12430 　

    ISSN： 2574-173X

    eISSN： 2574-173X

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    Abstract Aim Postmortem brain research is necessary for elucidating the pathology of schizophrenia; an increasing number of studies require a combination of suitable tissue samples preserved at multiple brain banks. In this study, we examined whether a comparative study of protein expression levels can be conducted using postmortem brain samples preserved in different facilities. Methods We compared the demographic factors of postmortem brain samples preserved in two institutions and measured and compared the expression levels of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) and glial fibrillary acidic protein (GFAP) in the prefrontal cortex and superior temporal gyrus. GAPDH is generally used as a loading control for western blotting, and GFAP is considered as an astrocyte marker in the brain. Results We found significant differences between the two institutions in postmortem interval, age at death, and preservation time. To reduce the effects of these differences on our measurements, the parameters were set as covariates in our analyses of covariance. Subsequently, no differences in GAPDH and GFAP expression were found between institutions. Conclusions When studies are conducted using brain samples preserved in different brain banks, differences in demographic factors should be carefully considered and taken into account by statistical methods to minimize their impact as much as possible. Since there was no significant difference in the protein expression levels of GAPDH and GFAP in either region between the two institutions that preserved the postmortem brains, we concluded that it is possible to perform protein quantitative analysis assuming that there is no effect of difference between two institutions.

  12. Marked alteration of phosphoinositide signaling‐associated molecules in postmortem prefrontal cortex with bipolar disorder

    Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe

    Neuropsychopharmacology Reports　2024/03

    DOI： 10.1002/npr2.12409 　

  13. A single-cell atlas of transcribedcis-regulatory elements in the human genome

    Jonathan Moody, Tsukasa Kouno, Miki Kojima, Ikuko Koya, Julio Leon, Akari Suzuki, Akira Hasegawa, Taishin Akiyama, Nobuko Akiyama, Masayuki Amagai, Jen-Chien Chang, Ayano Fukushima-Nomura, Mika Handa, Kazunori Hino, Mizuki Hino, Tomoko Hirata, Yuuki Imai, Kazunori Inoue, Hiroshi Kawasaki, Toshihiro Kimura, Tomofumi Kinoshita, Ken-ichiro Kubo, Yasuto Kunii, Fernando López-Redondo, Riichiro Manabe, Tomohiro Miyai, Satoru Morimoto, Atsuko Nagaoka, Jun Nakajima, Shohei Noma, Yasushi Okazaki, Kokoro Ozaki, Noritaka Saeki, Hiroshi Sakai, Kuniaki Seyama, Youtaro Shibayama, Tomohisa Sujino, Michihira Tagami, Hayato Takahashi, Masaki Takao, Masaru Takeshita, Tsuyoshi Takiuchi, Chikashi Terao, Chi Wai Yip, Satoshi Yoshinaga, Hideyuki Okano, Kazuhiko Yahamoto, Takeya Kasukawa, Yoshinari Ando, Piero Carninci, Jay W. Shin, Chung-Chau Hon

    2023/11/14

    Publisher: Cold Spring Harbor Laboratory

    DOI： 10.1101/2023.11.13.566791 　

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    Summary Transcribed cis-regulatory elements (tCREs), such as promoters and enhancers, are fundamental to modulate gene expression and define cell identity. The detailed mapping of tCREs at single-cell resolution is essential for understanding the regulatory mechanisms that govern cellular functions. Prior tCRE catalogs, limited by bulk analysis, have often overlooked cellular heterogeneity. We have constructed a tCRE atlas using single-cell 5’-RNA-seq, capturing over 340,000 single-cells from 23 human tissues and annotating more than 175,000 tCREs, substantially enhancing the scope and granularity of existingcis-regulatory element annotations in the human genome. This atlas unveils patterns of gene regulation, revealing connections between broadly expressed promoters and cell type-specific distal tCREs. Assessing trait heritability at single-cell resolution with a novel tCRE module-based approach, we uncovered the nuanced trait-gene regulatory relationships across a continuum of cell populations, offering insights beyond traditional gene-level and bulk-sample analyses. Our study bridges the gap between gene regulation and trait heritability, underscoring the potential of single-cell analysis to elucidate the genetic foundations of complex traits. These insights set the stage for future research to investigate the impact of genetic variations on diseases at the individual level, advancing the understanding of cellular and molecular basis of trait heritability.

  14. Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics International-journal

    Kazusa Miyahara, Mizuki Hino, Risa Shishido, Ryuta Izumi, Atsuko Nagaoka, Hideki Hayashi, Akiyoshi Kakita, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

    Journal of Psychiatric Research　166　10-16　2023/10

    Publisher: Elsevier BV

    DOI： 10.1016/j.jpsychires.2023.08.007 　

    ISSN： 0022-3956

    eISSN： 1879-1379

  15. Editorial: Molecular pathology in psychiatric diseases: frontiers of postmortem brain research International-journal

    Yasuto Kunii, Mizuki Hino, Hiroaki Tomita

    Frontiers in Psychiatry　14　1286182-1286182　2023/09/27

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyt.2023.1286182 　

    eISSN： 1664-0640

  16. The influence of tissue pH and RNA integrity number on gene expression of human postmortem brain International-journal

    Kazusa Miyahara, Mizuki Hino, Zhiqian Yu, Chiaki Ono, Atsuko Nagaoka, Masataka Hatano, Risa Shishido, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

    Frontiers in Psychiatry　14　1156524-1156524　2023/07/14

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyt.2023.1156524 　

    eISSN： 1664-0640

  17. Disease specific brain capillary angiopathy in schizophrenia, bipolar disorder, and Alzheimer's disease. International-journal

    Shinobu Hirai, Atsuhiro Sakuma, Yasuto Kunii, Hiroko Shimbo, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Rika Kojima, Erika Seki, Nobutaka Arai, Takashi Komori, Haruo Okado

    Journal of psychiatric research　163　74-79　2023/07

    DOI： 10.1016/j.jpsychires.2023.04.011 　

    ISSN： 0022-3956

    eISSN： 1879-1379

  18. On the Mental Health Needs Under the Russian Invasion in Ternopil, Ukraine: A Preliminary Report on the Provision of Mental Health Service International-journal

    Mizuki Hino, Yasuto Kunii, Bogdan I. Gerashchenko, Yumiko Hamaie, Shinichi Egawa, Shinichi Kuriyama, Oksana O. Shevchuk, Mykhaylo M. Korda, Olena P. Venher, Hiroaki Tomita

    Annals of Global Health　89　(1)　41-41　2023/06/08

    Publisher: Ubiquity Press, Ltd.

    DOI： 10.5334/aogh.4076 　

    ISSN： 2214-9996

    eISSN： 2214-9996

  19. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability International-journal

    Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Ryoko Kimura, Yumiko Hamaie, Mizuki Hino, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Susumu Fujii, Masaharu Nakayama, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

    Frontiers in Psychiatry　14　1104222-1104222　2023/06/06

    Publisher: Frontiers Media SA

    DOI： 10.3389/fpsyt.2023.1104222 　

    eISSN： 1664-0640

  20. Identification of schizophrenia symptom-related gene modules by postmortem brain transcriptome analysis. International-journal

    Kazusa Miyahara, Mizuki Hino, Risa Shishido, Atsuko Nagaoka, Ryuta Izumi, Hideki Hayashi, Akiyoshi Kakita, Hirooki Yabe, Hiroaki Tomita, Yasuto Kunii

    Translational psychiatry　13　(1)　144-144　2023/05/04

    DOI： 10.1038/s41398-023-02449-8 　

    eISSN： 2158-3188

  21. Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia. International-journal

    Risa Shishido, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita, Hirooki Yabe

    Frontiers in psychiatry　14　1183696-1183696　2023

    DOI： 10.3389/fpsyt.2023.1183696 　

    eISSN： 1664-0640

  22. Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model. International-journal

    Yuriko Iwakura, Ryoka Kawahara-Miki, Satoshi Kida, Hidekazu Sotoyama, Ramil Gabdulkhaev, Hitoshi Takahashi, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Ryuta Izumi, Risa Shishido, Toshiyuki Someya, Hirooki Yabe, Akiyoshi Kakita, Hiroyuki Nawa

    Neurochemical research　47　(9)　2715-2727　2022/04/25

    DOI： 10.1007/s11064-022-03599-9 　

    ISSN： 0364-3190

    eISSN： 1573-6903

  23. Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia International-journal

    Wataru Arihisa, Takeshi Kondo, Katsushi Yamaguchi, Junya Matsumoto, Hiroki Nakanishi, Yasuto Kunii, Hiroyasu Akatsu, Mizuki Hino, Yoshio Hashizume, Shumpei Sato, Shinji Sato, Shin-Ichi Niwa, Hirooki Yabe, Takehiko Sasaki, Shuji Shigenobu, Mitsutoshi Setou

    Neuropsychopharmacology Reports　43　(3)　403-413　2022/03/16

    Publisher: Cold Spring Harbor Laboratory

    DOI： 10.1101/2022.03.14.483348 　

    eISSN： 2574-173X

  24. Real-Time Prediction of Medical Demand and Mental Health Status in Ukraine under Russian Invasion Using Tweet Analysis

    Susumu Fujii, Yasuto Kunii, Sayuri Nonaka, Yumiko Hamaie, Mizuki Hino, Shinichi Egawa, Shinichi Kuriyama, Hiroaki Tomita

    The Tohoku Journal of Experimental Medicine　259　(3)　177-188　2022

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j111 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  25. Tubulin/microtubules as novel clozapine targets International-journal

    Mizuki Hino, Takeshi Kondo, Yasuto Kunii, Junya Matsumoto, Akira Wada, Shin-ichi Niwa, Mitsutoshi Setou, Hirooki Yabe

    Neuropsychopharmacology Reports　42　(1)　32-41　2021/12/28

    Publisher: Wiley

    DOI： 10.1002/npr2.12221 　

    ISSN： 2574-173X

    eISSN： 2574-173X

  26. High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice International-journal

    Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Tomoya Nakamachi, Seiji Shioda, Takashi Dan, Toshio Miyata, Yasumasa Nishito, Kazuhiro Suzuki, Mitsuhiro Miyashita, Toshifumi Tomoda, Takatoshi Hikida, Junjiro Horiuchi, Masanari Itokawa, Makoto Arai, Haruo Okado

    Science Advances　7　(46)　eabl6077　2021/11/12

    DOI： 10.1126/sciadv.abl6077 　

    ISSN： 2375-2548

    eISSN： 2375-2548

  27. Dysregulation of DPYSL2 expression by mTOR signaling in schizophrenia: Multi-level study of postmortem brain. International-journal

    Ryuta Izumi, Mizuki Hino, Atsuko Nagaoka, Risa Shishido, Akiyoshi Kakita, Mikio Hoshino, Yasuto Kunii, Hirooki Yabe

    Neuroscience research　175　73-81　2021/09/17

    DOI： 10.1016/j.neures.2021.09.004 　

    ISSN： 0168-0102

    eISSN： 1872-8111

  28. Evidence for Altered Phosphoinositide Signaling-Associated Molecules in the Postmortem Prefrontal Cortex of Patients with Schizophrenia. International-journal

    Yasuto Kunii, Junya Matsumoto, Ryuta Izumi, Atsuko Nagaoka, Mizuki Hino, Risa Shishido, Makoto Sainouchi, Hiroyasu Akatsu, Yoshio Hashizume, Akiyoshi Kakita, Hirooki Yabe

    International journal of molecular sciences　22　(15)　2021/07/31

    DOI： 10.3390/ijms22158280 　

    ISSN： 1661-6596

    eISSN： 1422-0067

  29. Detailed Postmortem Profiling of Inflammatory Mediators Expression Revealed Post-inflammatory Alternation in the Superior Temporal Gyrus of Schizophrenia. International-journal

    Ryuta Izumi, Mizuki Hino, Akira Wada, Atsuko Nagaoka, Takashi Kawamura, Tsutomu Mori, Makoto Sainouchi, Akiyoshi Kakita, Kiyoto Kasai, Yasuto Kunii, Hirooki Yabe

    Frontiers in psychiatry　12　653821-653821　2021

    DOI： 10.3389/fpsyt.2021.653821 　

    ISSN： 1664-0640

    eISSN： 1664-0640

  30. Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity. International-journal Peer-reviewed

    Hiroshi Komatsu, Hikaru Takeuchi, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Kunio Iizuka, Yuji Takano, Yoshihisa Kakuto, Shunichi Funakoshi, Takashi Ono, Junko Ito, Yasuto Kunii, Mizuki Hino, Atsuko Nagaoka, Yasushi Iwasaki, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Hirotsugu Azechi, Noriko Kudo, Ryota Hashimoto, Hirooki Yabe, Mari Yoshida, Yuko Saito, Akiyoshi Kakita, Nobuo Fuse, Ryuta Kawashima, Yasuyuki Taki, Hiroaki Tomita

    Schizophrenia bulletin　46　(6)　1619-1628　2020/12/01

    DOI： 10.1093/schbul/sbaa049 　

    ISSN： 0586-7614

    eISSN： 1745-1701

  31. ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism. International-journal

    Atsuko Nagaoka, Yasuto Kunii, Mizuki Hino, Ryuta Izumi, Chisato Nagashima, Akari Takeshima, Makoto Sainouchi, Hiroyuki Nawa, Akiyoshi Kakita, Hirooki Yabe

    Journal of psychiatric research　123　119-127　2020/04

    DOI： 10.1016/j.jpsychires.2020.02.001 　

    ISSN： 0022-3956

    eISSN： 1879-1379

  32. Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder International-journal Peer-reviewed

    Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Atsuko Nagaoka, Hiroyuki Nawa, Akiyoshi Kakita, Hiroyasu Akatsu, Yoshio Hashizume, Hirooki Yabe

    Scientific Reports　9　(1)　14877-14877　2019/12

    Publisher: Springer Science and Business Media {LLC}

    DOI： 10.1038/s41598-019-51456-7 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  33. Minimal amount of tissue-based pH measurement to improve quality control in neuropsychiatric post-mortem brain studies. International-journal Peer-reviewed

    Chiaki T Ono, Zhiqian Yu, Yoshie Kikuchi, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Atsuko Nagaoka, Junko Ito, Yasushi Iwasaki, Hideo Hagihara, Tsuyoshi Miyakawa, Mari Yoshida, Yuko Saito, Shin-Ichi Niwa, Hirooki Yabe, Akiyoshi Kakita, Hiroaki Tomita

    Psychiatry and clinical neurosciences　73　(9)　566-573　2019/09

    Publisher: Wiley

    DOI： 10.1111/pcn.12863 　

    ISSN： 1323-1316

    eISSN： 1440-1819

  34. Investigation of betaine as a novel psychotherapeutic for schizophrenia. International-journal Peer-reviewed

    Tetsuo Ohnishi, Shabeesh Balan, Manabu Toyoshima, Motoko Maekawa, Hisako Ohba, Akiko Watanabe, Yoshimi Iwayama, Yuko Fujita, Yunfei Tan, Yasuko Hisano, Chie Shimamoto-Mitsuyama, Yayoi Nozaki, Kayoko Esaki, Atsuko Nagaoka, Junya Matsumoto, Mizuki Hino, Nobuko Mataga, Akiko Hayashi-Takagi, Kenji Hashimoto, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Takeo Yoshikawa

    EBioMedicine　45　432-446　2019/07

    DOI： 10.1016/j.ebiom.2019.05.062 　

    ISSN： 2352-3964

    eISSN： 2352-3964

  35. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. International-journal Peer-reviewed

    Takayuki Yukawa, Yuriko Iwakura, Nobuyuki Takei, Mami Saito, Yuichiro Watanabe, Kazuhiko Toyooka, Michihiro Igarashi, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Shuji Iritani, Shin-Ichi Niwa, Ryoko Takeuchi, Hitoshi Takahashi, Akiyoshi Kakita, Toshiyuki Someya, Hiroyuki Nawa

    Psychiatry research　270　940-946　2018/12

    DOI： 10.1016/j.psychres.2018.10.062 　

    ISSN： 0165-1781

    eISSN： 1872-7123

  36. Influences of the T102C polymorphism in the 5-HT2A receptor gene on the five-factor model of Positive and Negative Syndrome Scale and treatment response to aripiprazole in patients with acute schizophrenia. International-journal Peer-reviewed

    Keiko Kanno-Nozaki, Itaru Miura, Haruka Kaneko, Sho Horikoshi, Takafumi Ota, Michinari Nozaki, Hiroki Ejiri, Mitsuharu Yahiro, Kenya Watanabe, Mizuki Hino, Hirooki Yabe

    Psychiatry research　265　244-245　2018/07

    DOI： 10.1016/j.psychres.2018.05.020 　

    ISSN： 1872-7123 0165-1781

    eISSN： 1872-7123

  37. Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia. International-journal Peer-reviewed

    Junya Matsumoto, Atsuko Nagaoka, Yasuto Kunii, Itaru Miura, Mizuki Hino, Shin-Ichi Niwa, Hiroyuki Nawa, Hitoshi Takahashi, Akiyoshi Kakita, Hirooki Yabe

    Psychiatry research　264　116-118　2018/06

    DOI： 10.1016/j.psychres.2018.03.029 　

    ISSN： 1872-7123 0165-1781

    eISSN： 1872-7123

  38. <em>COMT</em> Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia International-journal Peer-reviewed

    Haruka Kaneko, Itaru Miura, Keiko Kanno-Nozaki, Sho Horikoshi, Mizuki Hino, Hirooki Yabe

    Neuropsychiatric Disease and Treatment　Volume 14　1657-1663　2018/06

    DOI： 10.2147/NDT.S164647 　

    ISSN： 1176-6328

    eISSN： 1178-2021

  39. DNA methylation of ANKK1 and response to aripiprazole in patients with acute schizophrenia: A preliminary study. International-journal Peer-reviewed

    Itaru Miura, Yasuto Kunii, Mizuki Hino, Hiroshi Hoshino, Junya Matsumoto, Keiko Kanno-Nozaki, Sho Horikoshi, Haruka Kaneko, Miki Bundo, Kazuya Iwamoto, Hirooki Yabe

    Journal of psychiatric research　100　84-87　2018/05

    DOI： 10.1016/j.jpsychires.2018.02.018 　

    ISSN： 1879-1379 0022-3956

    eISSN： 1879-1379

  40. PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex. International-journal Peer-reviewed

    Keisuke Nishiura, Naoki Ichikawa-Tomikawa, Kotaro Sugimoto, Yasuto Kunii, Korehito Kashiwagi, Mizuko Tanaka, Yuichi Yokoyama, Mizuki Hino, Takashi Sugino, Hirooki Yabe, Hitoshi Takahashi, Akiyoshi Kakita, Tetsuya Imura, Hideki Chiba

    Oncotarget　8　(55)　93382-93391　2017/11/07

    DOI： 10.18632/oncotarget.21850 　

    ISSN： 1949-2553

    eISSN： 1949-2553

  41. High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates. International-journal Peer-reviewed

    Kaoru Seiriki, Atsushi Kasai, Takeshi Hashimoto, Wiebke Schulze, Misaki Niu, Shun Yamaguchi, Takanobu Nakazawa, Ken-Ichi Inoue, Shiori Uezono, Masahiko Takada, Yuichiro Naka, Hisato Igarashi, Masato Tanuma, James A Waschek, Yukio Ago, Kenji F Tanaka, Atsuko Hayata-Takano, Kazuki Nagayasu, Norihito Shintani, Ryota Hashimoto, Yasuto Kunii, Mizuki Hino, Junya Matsumoto, Hirooki Yabe, Takeharu Nagai, Katsumasa Fujita, Toshio Matsuda, Kazuhiro Takuma, Akemichi Baba, Hitoshi Hashimoto

    Neuron　94　(6)　1085-1100　2017/06/21

    DOI： 10.1016/j.neuron.2017.05.017 　

    ISSN： 0896-6273

    eISSN： 1097-4199

  42. Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics. International-journal Peer-reviewed

    Mio Hirayama-Kurogi, Yohei Takizawa, Yasuto Kunii, Junya Matsumoto, Akira Wada, Mizuki Hino, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, Takeshi Kondo, Shingo Ito, Masanori Tachikawa, Shin-Ichi Niwa, Hirooki Yabe, Tetsuya Terasaki, Mitsutoshi Setou, Sumio Ohtsuki

    Journal of proteomics　158　31-42　2017/03/31

    DOI： 10.1016/j.jprot.2017.02.009 　

    ISSN： 1874-3919

    eISSN： 1876-7737

  43. Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. International-journal Peer-reviewed

    Junya Matsumoto, Hiroki Nakanishi, Yasuto Kunii, Yuki Sugiura, Dai Yuki, Akira Wada, Mizuki Hino, Shin-Ichi Niwa, Takeshi Kondo, Michihiko Waki, Takahiro Hayasaka, Noritaka Masaki, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, Shinji Sato, Takehiko Sasaki, Mitsutoshi Setou, Hirooki Yabe

    Scientific reports　7　45050-45050　2017/03/23

    DOI： 10.1038/srep45050 　

    ISSN： 2045-2322

    eISSN： 2045-2322

  44. Prominent increased calcineurin immunoreactivity in the superior temporal gyrus in schizophrenia: A postmortem study International-journal Peer-reviewed

    Akira Wada, Yasuto Kunii, Jyunya Matsumoto, Mizuki Hino, Qiaohui Yang, Shin-ichi Niwa, Hirooki Yabe

    Psychiatry Research　247　79-83　2017/01

    DOI： 10.1016/j.psychres.2016.11.018 　

    ISSN： 0165-1781

    eISSN： 1872-7123

  45. Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia International-journal Peer-reviewed

    Mizuki Hino, Yasuto Kunii, Junya Matsumoto, Akira Wada, Atsuko Nagaoka, Shin-ichi Niwa, Hitoshi Takahashi, Akiyoshi Kakita, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, Hirooki Yabe

    Journal of Psychiatric Research　82　100-108　2016/11

    DOI： 10.1016/j.jpsychires.2016.07.018 　

    ISSN： 0022-3956

    eISSN： 1879-1379

  46. Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia International-journal Peer-reviewed

    Akira Wada, Yasuto Kunii, Jyunya Matsumoto, Mizuki Hino, Atsuko Nagaoka, Shin-ichi Niwa, Hirooki Yabe

    Neuropsychiatric Disease and Treatment　Volume 12　1645-1650　2016/07

    DOI： 10.2147/ndt.s106371 　

    ISSN： 1178-2021

    eISSN： 1178-2021

  47. Association of DNA Methylation of Taq1A in the DRD2 with Response to Aripiprazole in acute schizophrenia

    Itaru Miura, Miki Bundo, Mizuki Hino, Sho Horikoshi, Hiroshi Hoshino, Kazuya Iwamoto, Haruka Kaneko, Keiko Kanno-Nozaki, Yasuto Kunii, Junya Matsumoto, Hirooki Yabe

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　19　236-236　2016/06

    ISSN： 1461-1457

    eISSN： 1469-5111

  48. Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole. International-journal Peer-reviewed

    Itaru Miura, Keiko Kanno-Nozaki, Mizuki Hino, Sho Horikoshi, Takafumi Ota, Hirobumi Mashiko, Shin-Ichi Niwa, Hirooki Yabe

    Journal of clinical psychopharmacology　35　(3)　333-4　2015/06

    DOI： 10.1097/JCP.0000000000000330 　

    ISSN： 0271-0749

    eISSN： 1533-712X

  49. Assessment of copy number variations in the brain genome of schizophrenia patients. International-journal Peer-reviewed

    Miwako Sakai, Yuichiro Watanabe, Toshiyuki Someya, Kazuaki Araki, Masako Shibuya, Kazuhiro Niizato, Kenichi Oshima, Yasuto Kunii, Hirooki Yabe, Junya Matsumoto, Akira Wada, Mizuki Hino, Takeshi Hashimoto, Akitoyo Hishimoto, Noboru Kitamura, Shuji Iritani, Osamu Shirakawa, Kiyoshi Maeda, Akinori Miyashita, Shin-Ichi Niwa, Hitoshi Takahashi, Akiyoshi Kakita, Ryozo Kuwano, Hiroyuki Nawa

    Molecular cytogenetics　8　(1)　46-46　2015

    DOI： 10.1186/s13039-015-0144-5 　

    ISSN： 1755-8166

    eISSN： 1755-8166

  50. Elevated postmortem striatal t-DARPP expression in schizophrenia and associations with DRD2/ANKK1 polymorphism. International-journal Peer-reviewed

    Yasuto Kunii, Itaru Miura, Junya Matsumoto, Mizuki Hino, Akira Wada, Shin-ichi Niwa, Hiroyuki Nawa, Miwako Sakai, Toshiyuki Someya, Hitoshi Takahashi, Akiyoshi Kakita, Hirooki Yabe

    Progress in neuro-psychopharmacology & biological psychiatry　53　123-8　2014/08/04

    DOI： 10.1016/j.pnpbp.2014.03.014 　

    ISSN： 1878-4216 0278-5846

    eISSN： 1878-4216

  51. X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons International-journal Peer-reviewed

    Katsuyuki Shirai, Toshiyuki Mizui, Yoshiyuki Suzuki, Masahiko Okamoto, Kenji Hanamura, Yukari Yoshida, Mizuki Hino, Shin-ei Noda, Wael S. Al-jahdari, Arnab Chakravarti, Tomoaki Shirao, Takashi Nakano

    Radiation Research　179　(6)　630-636　2013/06

    DOI： 10.1667/rr3098.1 　

    ISSN： 0033-7587

    eISSN： 1938-5404

  52. Utilization of myosin and actin bundles for the transport of molecular cargo. International-journal Peer-reviewed

    Hideyo Takatsuki, Kevin M Rice, Shinichi Asano, B Scott Day, Mizuki Hino, Kazuhiro Oiwa, Ryoki Ishikawa, Yuichi Hiratsuka, Taro Q P Uyeda, Kazuhiro Kohama, Eric R Blough

    Small (Weinheim an der Bergstrasse, Germany)　6　(3)　452-7　2010/02/05

    DOI： 10.1002/smll.200901369 　

    ISSN： 1613-6810

    eISSN： 1613-6829

  53. Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain. International-journal Peer-reviewed

    Takeshi Katayama, Masaru Watanabe, Hideyuki Tanaka, Mizuki Hino, Takuya Miyakawa, Takashi Ohki, Li-Hong Ye, Ce Xie, Shinji Yoshiyama, Akio Nakamura, Ryoki Ishikawa, Masaru Tanokura, Kazuhiro Oiwa, Kazuhiro Kohama

    American journal of physiology. Heart and circulatory physiology　298　(2)　H505-14-H514　2010/02

    DOI： 10.1152/ajpheart.00577.2009 　

    ISSN： 0363-6135

    eISSN： 1522-1539

  54. Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells. Peer-reviewed

    Mizuki Hino, Nobuyuki Hamada, Yuki Tajika, Tomoo Funayama, Yoshihiro Morimura, Tetsuya Sakashita, Yuichiro Yokota, Kana Fukamoto, Yasuko Mutou, Yasuhiko Kobayashi, Hiroshi Yorifuji

    Journal of electron microscopy　59　(6)　495-501　2010

    DOI： 10.1093/jmicro/dfq059 　

    ISSN： 0022-0744

    eISSN： 1477-9986

  55. VAMP2 Marks Quiescent Satellite Cells and Myotubes, but not Activated Myoblasts Peer-reviewed

    Yuki Tajika, Maiko Takahashi, Mizuki Hino, Tohru Murakami, Hiroshi Yorifuji

    ACTA HISTOCHEMICA ET CYTOCHEMICA　43　(4)　107-114　2010

    DOI： 10.1267/ahc.10010 　

    ISSN： 0044-5991

    eISSN： 1347-5800

  56. Insufficient Membrane Fusion in Dysferlin-Deficient Muscle Fibers after Heavy-Ion Irradiation Peer-reviewed

    Mizuki Hino, Nobuyuki Hamada, Yuki Tajika, Tomoo Funayama, Yoshihiro Morimura, Tetsuya Sakashita, Yuichiro Yokota, Kana Fukamoto, Yasuhiko Kobayashi, Hiroshi Yorifuji

    Cell Structure and Function　34　(1)　11-15　2009

    DOI： 10.1247/csf.08033 　

    ISSN： 0386-7196

    eISSN： 1347-3700

  57. Calcium inhibition of Physarum myosin as examined by the recombinant heavy mero-myosin. International-journal Peer-reviewed

    Hozumi Kawamichi, Ying Zhang, Mizuki Hino, Akio Nakamura, Hideyuki Tanaka, Lászlo Farkas, Lászlo Nyitray, Kazuhiro Kohama

    Advances in experimental medicine and biology　592　265-72　2007

    DOI： 10.1007/978-4-431-38453-3_22 　

    ISSN： 0065-2598

  58. Heavy Ion Microbeam Irradiation Induces Ultrastructural Changes in Isolated Single Fibers of Skeletal Muscle Peer-reviewed

    Mizuki Hino, Seiichi Wada, Yuki Tajika, Yoshihiro Morimura, Nobuyuki Hamada, Tomoo Funayama, Tetsuya Sakashita, Takehiko Kakizaki, Yasuhiko Kobayashi, Hiroshi Yorifuji

    Cell Structure and Function　32　(1)　51-56　2007

    DOI： 10.1247/csf.06038 　

    ISSN： 0386-7196

    eISSN： 1347-3700

  59. Protective role of HSP27 against UVC-induced cell death in human cells. International-journal Peer-reviewed

    Chieko Wano, Kazuko Kita, Shunji Takahashi, Shigeru Sugaya, Mizuki Hino, Hiroshi Hosoya, Nobuo Suzuki

    Experimental cell research　298　(2)　584-92　2004/08/15

    DOI： 10.1016/j.yexcr.2004.04.048 　

    ISSN： 0014-4827

  60. Glycosylation of the Alpha and Beta Tubulin by Sialyloligosaccharides Peer-reviewed

    Mizuki Hino, Isao Kijima-Suda, Yoshitaka Nagai, Hiroshi Hosoya

    Zoological Science　20　(6)　709-715　2003/06

    DOI： 10.2108/zsj.20.709 　

    ISSN： 0289-0003

  61. Small Heat Shock Protein Hsp27 Directly Binds to Alpha/Beta Tnbulin Heterodimer and Inhibits DMSO-Induced Tubulin Polymerization Peer-reviewed

    Mizuki HINO, Hiroshi HOSOYA

    Biomedical Research　24　(1)　27-30　2003

    DOI： 10.2220/biomedres.24.27 　

    ISSN： 0388-6107

    eISSN： 1880-313X

  62. A New Digalactosyl Diacylglycerol from a Cultured Marine DinoflagellateHeterocapsacircularisquama International-journal Peer-reviewed

    Yoshikazu Hiraga, Ken Kaku, Daisuke Omoda, Kinuko Sugihara, Hiroshi Hosoya, Mizuki Hino

    Journal of Natural Products　65　(10)　1494-1496　2002/10

    DOI： 10.1021/np0201265 　

    ISSN： 0163-3864

  63. Phosphorylation at threonine-18 in addition to phosphorylation at serine-19 on myosin-II regulatory light chain is a mitosis-specific event International-journal Peer-reviewed

    Bogdan I. Gerashchenko, Kozue Ueda, Mizuki Hino, Hiroshi Hosoya

    Cytometry　47　(3)　150-157　2002/02

    DOI： 10.1002/cyto.10059 　

    ISSN： 0196-4763

  64. Small Heat Shock Protein 27 (HSP27) Associates with Tubulin/Microtubules in HeLa Cells Peer-reviewed

    Mizuki Hino, Kazuki Kurogi, Masa-Aki Okubo, Maki Murata-Hori, Hiroshi Hosoya

    Biochemical and Biophysical Research Communications　271　(1)　164-169　2000/04

    DOI： 10.1006/bbrc.2000.2553 　

    ISSN： 0006-291X

  65. Enrichment for late-telophase cell populations using flow cytometry

    Bogdan I. Gerashchenko, Mizuki Hino, Hiroshi Hosoya

    Cytometry　41　(2)　148-149　2000

    DOI： 10.1002/1097-0320(20001001)41:2<148::aid-cyto11>3.0.co;2-0 　

    ISSN： 0196-4763

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    Japanese Journal of Biological Psychiatr　37　(1)　2026/03

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  12. 災害派遣精神医療チームDPAT発足から10年、これからの災害精神支援の課題と展望 DPAT体制と災害後長期の被災地域の心理社会的支援体制に関する課題と展望

    富田 博秋, 國井 泰人, 濱家 由美子, 日野 瑞城, 内海 裕介, 冨本 和歩, 瀬戸 萌

    精神神経学雑誌　(2024特別号)　S438-S438　2024/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  13. マウスの不安様行動とミクログリアオキシトシン発現に対する性差の影響

    兪 志前, 坂井 舞, 菊地 淑恵, 小野 千晶, 日野 瑞城, 國井 泰人, 富田 博秋

    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集　34回・54回　JP8-6　2024/05

    Publisher: 日本臨床精神神経薬理学会・日本神経精神薬理学会

  14. 統合失調症死後脳におけるプロリン代謝経路分子の解析

    長岡敦子, 長岡敦子, 日野瑞城, 旗野将貴, 細貝優人, 宍戸理紗, 柿田明美, 三浦至, 國井泰人, 國井泰人, 富田博秋

    統合失調症研究(CD-ROM)　13　(1)　2024

  15. 自殺者死後脳における炎症関連遺伝子の破局的な発現変動

    旗野将貴, 長岡敦子, 長岡敦子, 細貝優人, 宍戸理紗, 日野瑞城, 日野瑞城, 濱崎英臣, 柿田明美, 富田博秋, 富田博秋, 三浦至, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　46th　2024

  16. 自殺者死後脳における炎症関連遺伝子の顕著な発現変動-東北精神疾患ブレインバンク集積例からの考察

    旗野将貴, 長岡敦子, 長岡敦子, 細貝優人, 宍戸理紗, 日野瑞城, 日野瑞城, 國井泰人, 國井泰人, 國井泰人, 富田博秋, 富田博秋, 三浦至

    福島医学雑誌(Web)　74　(2)　2024

    ISSN： 2436-7826

  17. 統合失調症の淡蒼球肥大の分子病態

    宍戸理紗, 日野瑞城, 日野瑞城, 旗野将貴, 細貝優人, 長岡敦子, 長岡敦子, 濱崎英臣, 柿田明美, 富田博秋, 富田博秋, 三浦至, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　46th　2024

  18. 空間トランスクリプトミクスで解明する統合失調症における分子・細胞レベルの変化

    吉永怜史, 吉永怜史, レオン フリオ, 日野瑞城, 日野瑞城, 安藤吉成, ムーディ ジョナサン, 長岡敦子, 長岡敦子, 北澤彩子, 北澤彩子, 林周宏, 仲嶋一範, ホン ヂョンチョウ, 國井泰人, 國井泰人, シン ジェイ, 久保健一郎, 久保健一郎

    日本生物学的精神医学会(Web)　46th　2024

  19. 統合失調症死後脳におけるアミノ酸分析

    長岡敦子, 長岡敦子, 日野瑞城, 日野瑞城, 宍戸理紗, 旗野将貴, 細貝優人, 濱崎英臣, 柿田明美, 三浦至, 國井泰人, 國井泰人, 國井泰人, 富田博秋, 富田博秋, 富田博秋

    日本生物学的精神医学会(Web)　46th　2024

  20. 空間的遺伝子発現解析をはじめとしたヒト死後脳組織の解析

    久保健一郎, 久保健一郎, 吉永怜史, 吉永怜史, レオン フリオ, レオン フリオ, 日野瑞城, 日野瑞城, 安藤吉成, 安藤吉成, ムーディ ジョナサン, 長岡敦子, 長岡敦子, 北澤彩子, 北澤彩子, 林周宏, 仲嶋一範, ホン ヂョンチョウ, 國井泰人, 國井泰人, シン ジェイ, シン ジェイ, シン ジェイ

    日本生物学的精神医学会(Web)　46th　2024

  21. 本邦の統合失調症患者における社会適応状況及び抗精神病薬使用の変化に関する10年間の追跡研究

    森湧平, 宍戸理沙, 日野瑞城, 佐藤亜希子, 長岡敦子, 旗野将貴, 細貝優人, 三浦至, 國井泰人, 國井泰人

    日本精神神経学会総会プログラム・抄録集　120th　2024

  22. 精神疾患ブレインバンクにおける生前登録時の自殺予防と自殺脳研究の取り組み

    長岡 敦子, 旗野 将貴, 細貝 優人, 宍戸 理紗, 日野 瑞城, 三浦 至, 國井 泰人, 富田 博秋

    総合病院精神医学　35　(Suppl.)　S-212　2023/11

    Publisher: (一社)日本総合病院精神医学会

    ISSN： 0915-5872

  23. ウクライナ侵攻に関するメンタルヘルス上の諸課題 ロシア侵攻下のウクライナにおけるメンタルヘルスの実態

    國井 泰人, 藤井 進, 日野 瑞城, 濱家 由美子, 野中 小百合, 江川 新一, 栗山 進一, 富田 博秋

    精神神経学雑誌　119th　(2023特別号)　S310-S310　2023/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  24. クロザピンの作用機序—Mechanism of action responsible for superior efficacy of clozapine—特集 統合失調症診療のフロントライン(Part 1)

    國井 泰人, 日野 瑞城, 富田 博秋

    臨床精神医学 = Japanese journal of clinical psychiatry　52　(4)　425-432　2023/04

    Publisher: 東京 : アークメディア

    ISSN： 0300-032X

  25. 自然災害下での精神的負担と不調—Mental burden and disorders under post-disaster settings of natural disasters—特集 災害・戦争と精神科

    富田 博秋, 國井 泰人, 濱家 由美子, 日野 瑞城, 栗山 進一

    精神科 = Psychiatry / 精神科編集委員会 編　42　(2)　261-268　2023/02

    Publisher: 東京 : 科学評論社

    ISSN： 1347-4790

  26. Marked alteration of phosphoinositide signaling-associated molecules in postmortem prefrontal cortex with bipolar disorder International-journal

    日野瑞城, 日野瑞城, 國井泰人, 國井泰人, 宍戸理沙, 長岡敦子, 長岡敦子, 松本純弥, 赤津裕康, 橋詰良夫, 林秀樹, 柿田明美, 富田博秋, 富田博秋

    日本生物学的精神医学会(Web)　45th　(1)　121-128　2023

    DOI： 10.1002/npr2.12409 　

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    AIM: The etiology of bipolar disorder (BD) remains unknown; however, lipid abnormalities in BD have received increasing attention in recent years. In this study, we examined the expression levels of enzyme proteins associated with the metabolic pathway of phosphoinositides (PIs) and their downstream effectors, protein kinase B (Akt1) and glycogen synthase kinase 3β (GSK3β), which have been assumed to be the targets of mood stabilizers such as lithium, in the postmortem brains of patients with BD. METHODS: The protein expression levels of phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1C), phosphatidylinositol 4-kinase alpha (PIK4CA), phosphatase and tensin homolog deleted from chromosome 10 (PTEN), Akt1, and GSK3β were measured using enzyme-linked immunosorbent assays and multiplex fluorescent bead-based immunoassays in the prefrontal cortex (PFC). Specifically, PTEN, Akt1, GSK3β, and PIP5K1C were measured in seven BD patients and 48 controls. Additionally, PIK4CA was analyzed in 10 cases and 34 controls. RESULTS: PTEN expression levels were markedly decreased in the PFCs of patients with BD, whereas those of Akt and GSK3β were prominently elevated. Moreover, patients medicated with lithium exhibited higher Akt1 expression levels and lower PTEN expression levels in comparison with the untreated group. CONCLUSION: Our results suggest that the expression levels of Akt1/GSK3β and its upstream regulator PTEN are considerably altered.

  27. Mental burden and disorders under post-disaster settings of natural disasters.

    富田博秋, 富田博秋, 國井泰人, 濱家由美子, 日野瑞城, 栗山進一

    月刊精神科　42　(2)　2023

    ISSN： 1347-4790

  28. Expression changes in molecules related to DNA double-strand break repair in a high stress response group of schizophrenia.

    宍戸理紗, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 三浦至, 富田博秋, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　45th　2023

  29. Gene expression analysis of ZDHHC family of protein S-palmitoylating enzymes in postmortem brains of patients with schizophrenia

    細貝優人, 日野瑞城, 日野瑞城, 宍戸理紗, 長岡敦子, 長岡敦子, 林秀樹, 柿田明美, 富田博秋, 三浦至, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　45th　2023

  30. Evaluation of the influence of confounding factors in comprehensive gene expression analysis of human postmortem brain

    旗野将貴, 宮原一総, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 兪志前, 林秀樹, 柿田明美, 富田博秋, 三浦至, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　45th　2023

  31. 蛍光顕微鏡を用いない細胞骨格の観察法の研究 V-カイコの血球細胞とカエルの腎臓の培養細胞を用いた細胞骨格の観察-

    片山豪, 野崎真史, 田中進, 日野瑞城

    日本生物教育学会全国大会研究発表要旨集　107th　2023

  32. Clinical Frontline of Schizophrenia: Part 1: Mechanism of action responsible for superior efficacy of clozapine

    國井泰人, 日野瑞城, 富田博秋, 富田博秋

    臨床精神医学　52　(4)　425-432　2023

    Publisher: (株)アークメディア

    ISSN： 0300-032X

  33. Schizophrenia Research Using Post-mortem Brains

    國井泰人, 日野瑞城, 富田博秋

    精神医学　65　(4)　417-424　2023

    Publisher: 東京 : 医学書院

    DOI： 10.11477/mf.1405206889 　

    ISSN： 0488-1281

    eISSN： 1882-126X

  34. Preliminary analysis of comprehensive DNA methylation status in frontal cortex samples from Japanese patients with psychiatric disorders

    藤井綾香, 仲地ゆたか, 日野瑞城, 宍戸理紗, 長岡敦子, 清田恵美, 今村悠子, 國井泰人, 文東美紀, 岩本和也

    日本生物学的精神医学会(Web)　45th　2023

  35. The forefront of mood disorder research translating into clinical practice: Recent advances in postmortem brain studies for mood disorders

    國井泰人, 國井泰人, 日野瑞城, 富田博秋, 富田博秋

    臨床精神医学　51　(10)　1151-1157　2022/10

    Publisher: (株)アークメディア

    ISSN： 0300-032X

  36. Current practices and challenges in psychiatric postmortem brain bank.

    長岡敦子, 國井泰人, 國井泰人, 大沼裕美, 日野瑞城, 日野瑞城, 泉竜太, 宍戸理紗, 矢部博興

    月刊精神科　40　(4)　416-421　2022/04

    Publisher: (有)科学評論社

    ISSN： 1347-4790

  37. Identification of DEGs in schizophrenia postmortem brains classified by stress-related molecules.

    宍戸理紗, 國井泰人, 國井泰人, 日野瑞城, 日野瑞城, 長岡敦子, 長岡敦子, 泉竜太, 柿田明美, 矢部博興

    日本生物学的精神医学会(Web)　44th　2022

  38. 統合失調症患者とそのモデル動物の聴覚野におけるEGR1/zif268の発現変化

    岩倉百合子, 岩倉百合子, 川原玲香, 喜田聡, 喜田聡, 外山英和, GABDULKHAEV Ramil, 高橋均, 國井泰人, 國井泰人, 日野瑞城, 日野瑞城, 長岡敦子, 泉竜太, 宍戸理紗, 染矢俊幸, 矢部博興, 柿田明美, 那波宏之, 那波宏之

    日本神経化学会大会抄録集(Web)　65th　2022

  39. OPRM1 rs1799971 polymorphism has an ethnicity-dependent impact on risk for schizophrenia by disturbing the opioids system: A Meta-analysis and Postmortem Brain Study

    宮原一総, 日野瑞城, 日野瑞城, 宍戸理紗, 泉竜太, 長岡敦子, 柿田明美, 矢部博興, 富田博秋, 富田博秋, 國井泰人, 國井泰人

    日本生物学的精神医学会(Web)　44th　2022

  40. 【ブレインバンク/死後脳研究】精神疾患ブレインバンクと死後脳研究の現在

    國井 泰人, 長岡 敦子, 日野 瑞城, 泉 竜太, 宍戸 理紗, 矢部 博興

    日本生物学的精神医学会誌　32　(4)　179-185　2021/12

    Publisher: 日本生物学的精神医学会

    ISSN： 2186-6619

    eISSN： 2186-6465

  41. 【ブレインバンク/死後脳研究】統合失調症死後脳におけるタンパク定量解析-ALDH4A1とその発現に影響する遺伝子多型

    長岡 敦子, 國井 泰人, 日野 瑞城, 泉 竜太, 宍戸 理紗, 齊ノ内 信, 柿田 明美, 矢部 博興

    日本生物学的精神医学会誌　32　(4)　186-190　2021/12

    Publisher: 日本生物学的精神医学会

    ISSN： 2186-6619

    eISSN： 2186-6465

  42. Current status of psychiatric brain bank and postmortem brain research Peer-reviewed

    Kunii Yasuto, Nagaoka Atsuko, Hino Mizuki, Izumi Ryuta, Shishido Risa, Yabe Hirooki

    Japanese Journal of Biological Psychiatry　32　(4)　179-185　2021/12

    Publisher: Japanese Society of Biological Psychiatry

    DOI： 10.11249/jsbpjjpp.32.4_179 　

    ISSN： 2186-6619

    eISSN： 2186-6465

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    Biological research that is being actively conducted from various directions is rapidly elucidating the pathophysiology of psychiatric diseases. Many postmortem brain studies have recently been performed to verify the findings of the above studies. For such postmortem brain researches, a systematic psychiatric brain bank that can provide brain samples suitable for study is essential. Since 1997 we have managed the systematic postmortem brain bank on psychiatric diseases specializes in schizophrenia for the first time in Japan in order to understand and cure psychiatric diseases and currently maintains 62 brain tissue resources. Since 2016, Japan Brain Bank Net (JBBN) has been organized, and brain banks in Japan are being networked nationwide in order to meet the wishes of nationwide pre‐registered donors. In this article, we show the practices of psychiatric postmortem brain bank in Japan and the outlines the current status of psychiatric disease studies using postmortem brain samples.

  43. Quantitative protein expression study in the postmortem brains of patients with schizophrenia‐ALDH4A1 expression and its association with genetic polymorphism Peer-reviewed

    Nagaoka Atsuko, Kunii Yasuto, Hino Mizuki, Izumi Ryuta, Shishido Risa, Sainouchi Makoto, Kakita Akiyoshi, Yabe Hirooki

    Japanese Journal of Biological Psychiatry　32　(4)　186-190　2021/12

    Publisher: Japanese Society of Biological Psychiatry

    DOI： 10.11249/jsbpjjpp.32.4_186_190 　

    ISSN： 2186-6619

    eISSN： 2186-6465

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    Protein expression studies in postmortem brain are necessary for investigating molecular mechanisms underlying the pathogenesis of neuropsychiatric disorders including schizophrenia. Since there are a number of confounding factors originated from various conditions other than pathological conditions in postmortem brain studies, so it is vital that evaluate and control them carefully. We have investigated the relationship between the expression level of candidate proteins in the postmortem brain of schizophrenia as an intermediate phenotype and their association with single nucleotide polymorphism (SNPs) . These studies have conducted using the postmortem brain samples with mainly psychiatric diseases preserved at Fukushima Brain Bank and them with healthy controls preserved at Brain Research Institute, Niigata University. In this article, we show the investigation whether differences between two different brain banks had any effect on protein expression in postmortem brain samples, and the study of Aldehyde dehydrogenase 4 family member A1 (ALDH4A1) expression levels in postmortem brains of patients with schizophrenia and their association with SNPs.

  44. Quantitative protein expression study in the postmortem brains of patients with schizophrenia-ALDH4A1 expression and its association with genetic polymorphism

    長岡敦子, 國井泰人, 國井泰人, 日野瑞城, 泉竜太, 宍戸理紗, 齊ノ内信, 柿田明美, 矢部博興

    日本生物学的精神医学会誌(Web)　32　(4)　2021

    ISSN： 2186-6465

  45. Current status of psychiatric brain bank and postmortem brain research

    國井泰人, 國井泰人, 長岡敦子, 日野瑞城, 泉竜太, 宍戸理紗, 矢部博興

    日本生物学的精神医学会誌(Web)　32　(4)　2021

    ISSN： 2186-6465

  46. 精神科ブレインバンク各拠点からの成果と今後の臨床への展望-精神科ブレインバンクへの期待その4- 福島精神疾患ブレインバンクの成果と今後の展望

    國井 泰人, 長岡 敦子, 泉 竜太, 日野 瑞城, 矢部 博興

    精神神経学雑誌　116th　(2020特別号)　S407-S407　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  47. 新規クロザピン結合タンパク質の探索 α/βチューブリンに対する相互作用

    國井 泰人, 日野 瑞城, 近藤 豪, 和田 明, 松本 純弥, 丹羽 真一, 瀬藤 光利, 矢部 博興

    精神神経学雑誌　116th　(2020特別号)　S306-S306　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  48. 統合失調症脳病態における脂質シグナル伝達の意義 死後脳研究

    國井 泰人, 松本 純弥, 泉 竜太, 長岡 敦子, 日野 瑞城, 赤津 裕康, 橋詰 良夫, 齊ノ内 信, 柿田 明美

    精神神経学雑誌　116th　(2020特別号)　S307-S307　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  49. 【精神科における脳回路研究の最前線】統合失調症におけるミスマッチ陰性電位(MMN)発生異常

    矢部 博興, 刑部 有佑, 落合 晴香, 和田 知紘, 森 湧平, 佐藤 彩, 錫谷 研, 羽金 裕也, 平山 緑香, 高橋 雄一, 菅野 和子, 星野 大, 日野 瑞城, 戸田 亘, 堀越 翔, 志賀 哲也, 國井 泰人, 三浦 至

    日本生物学的精神医学会誌　31　(3)　127-133　2020/09

    Publisher: 日本生物学的精神医学会

    ISSN： 2186-6619

    eISSN： 2186-6465

  50. Impaired generation of mismatch negativity (MMN) in schizophrenia

    Yabe Hirooki, Osakabe Yusuke, Ochiai Haruka, Wada Tomohiro, Mori Yuhei, Sato Aya, Suzutani Ken, Hagane Yuya, Hirayama Norika, Takahashi Yuichi, Kanno Kazuko, Hoshino Hiroshi, Hino Mizuki, Toda Wataru, Horikoshi Sho, Shiga Tetsuya, Kunii Yasuto, Miura Itaru

    Japanese Journal of Biological Psychiatry　31　(3)　127-133　2020/09

    Publisher: Japanese Society of Biological Psychiatry

    DOI： 10.11249/jsbpjjpp.31.3_127 　

    ISSN： 2186-6619

    eISSN： 2186-6465

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    Human brain has developed the neural system of automatic sound change detection as reflected by the mismatch negativity (MMN) Many studies including “omission‐MMN” study have given evidence for “memory trace theory”. Actually, omission‐MMN was evoked only with SOAs shorter than 160 ms, suggesting the existence of temporal window of integration (TWI) mechanism. This TWI of 160‐170ms corresponds to the length of the sound trace encoded in neural sensory memory. MMN has recently become one of favorable neurophysiological biomarkers in schizophrenia. A definite reduction in early schizophrenia was evident in MMN to duration (dMMN) but not frequency deviants. The impaired dMMN might be caused by the dysfunction of TWI. Importantly, dMMN might provide the prediction of conversion to psychosis when dMMN was recorded in clinically at risk‐mental state (ARMS) individuals. The main MMN generator is located in the superior temporal gyrus (STG) . Several neuroimaging studies have revealed structural abnormalities of STG in schizophrenia. MMN also suggests the impaired function of NMDA receptors. In the postmortem study, DARPP‐32 and calcineurin (CaN) are closely associated with the abnormalities in the dopamine and glutamate systems in schizophrenia. The DARPP‐32 and CaN‐related pathogenesis in schizophrenia were more severe in the STG than previously found in the prefrontal cortex. A meta‐analysis of MMN abnormality in schizophrenia exhibited a large effect size of 0.95 (CI=0.85‐1.04) . Based on the above findings, dMMN impairment in the STG is expected to be a promissing biomarker in schizophrenia.

  51. 新規クロザピン結合タンパク質の探索 α/βチューブリンに対する相互作用

    國井 泰人, 日野 瑞城, 近藤 豪, 和田 明, 松本 純弥, 丹羽 真一, 瀬藤 光利, 矢部 博興

    精神神経学雑誌　(2020特別号)　S306-S306　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  52. 統合失調症脳病態における脂質シグナル伝達の意義 死後脳研究

    國井 泰人, 松本 純弥, 泉 竜太, 長岡 敦子, 日野 瑞城, 赤津 裕康, 橋詰 良夫, 齊ノ内 信, 柿田 明美

    精神神経学雑誌　(2020特別号)　S307-S307　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  53. 精神科ブレインバンク各拠点からの成果と今後の臨床への展望-精神科ブレインバンクへの期待その4- 福島精神疾患ブレインバンクの成果と今後の展望

    國井 泰人, 長岡 敦子, 泉 竜太, 日野 瑞城, 矢部 博興

    精神神経学雑誌　(2020特別号)　S407-S407　2020/09

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  54. Involvement of complement C4 in Elevated inflammatory biotype in schizophrenia in postmortem brain study

    泉竜太, 宍戸理紗, 日野瑞城, 長岡敦子, 國井泰人, 國井泰人, 矢野博興

    日本神経精神薬理学会プログラム・抄録集　50回・42回・4回　194-194　2020/08

    Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会

  55. Impaired generation of mismatch negativity (MMN) in schizophrenia

    矢部博興, 刑部有佑, 落合晴香, 和田知紘, 森湧平, 佐藤彩, 錫谷研, 羽金裕也, 平山緑香, 高橋雄一, 菅野和子, 星野大, 日野瑞城, 戸田亘, 堀越翔, 志賀哲也, 國井泰人, 國井泰人, 三浦至

    日本生物学的精神医学会誌(Web)　31　(3)　2020

    ISSN： 2186-6465

  56. 統合失調症の死後脳におけるサイトカインIL-1のタンパク質発現解析

    泉竜太, 國井泰人, 國井泰人, 長岡敦子, 長岡敦子, 日野瑞城, 齊ノ内信, 柿田明美, 矢部博興

    統合失調症研究　10　(1)　2020

  57. 統合失調症と発達障害の鑑別診断における知能検査の有効性と社会機能予後との関連の検討

    長岡敦子, 國井泰人, 國井泰人, 泉竜太, 日野瑞城, 角田耕也, 矢部博興

    統合失調症研究　10　(1)　2020

  58. 統合失調症患者における脳内コンドロイチン硫酸鎖の変化

    湯川 尊行, 岩倉 百合子, 武井 延之, 斎藤 摩美, 渡部 雄一郎, 豊岡 和彦, 五十嵐 道弘, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 入谷 修司, 丹羽 真一, 竹内 亮子, 高橋 均, 柿田 明美, 染矢 俊幸, 那波 宏之

    精神神経学雑誌　(2019特別号)　S410-S410　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  59. 統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

    坂井 美和子, 渡部 雄一郎, 染矢 俊幸, 荒木 一明, 澁谷 雅子, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 橋本 健志, 菱本 明豊, 北村 登, 入谷 修司, 白川 治, 前田 潔, 宮下 哲典, 丹羽 真一, 高橋 均, 柿田 明美, 桑野 良三, 那波 宏之

    精神神経学雑誌　(2019特別号)　S603-S603　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  60. 統合失調症患者における脳内コンドロイチン硫酸鎖の変化

    湯川 尊行, 岩倉 百合子, 武井 延之, 斎藤 摩美, 渡部 雄一郎, 豊岡 和彦, 五十嵐 道弘, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 入谷 修司, 丹羽 真一, 竹内 亮子, 高橋 均, 柿田 明美, 染矢 俊幸, 那波 宏之

    精神神経学雑誌　115th　(2019特別号)　S410-S410　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  61. 統合失調症患者の脳内ゲノムにおけるコピー数変異の評価

    坂井 美和子, 渡部 雄一郎, 染矢 俊幸, 荒木 一明, 澁谷 雅子, 新里 和弘, 大島 健一, 國井 泰人, 矢部 博興, 松本 純弥, 和田 明, 日野 瑞城, 橋本 健志, 菱本 明豊, 北村 登, 入谷 修司, 白川 治, 前田 潔, 宮下 哲典, 丹羽 真一, 高橋 均, 柿田 明美, 桑野 良三, 那波 宏之

    精神神経学雑誌　115th　(2019特別号)　S603-S603　2019/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  62. 福島精神疾患ブレインバンクにおける自殺予防の取り組み

    泉竜太, 國井泰人, 國井泰人, 渡邉千明, 長岡敦子, 長岡敦子, 日野瑞城, 矢部博興

    統合失調症研究　9　(1)　2019

  63. タンパク質定量解析における異なる二施設間で保管された死後脳試料の質の検討

    長岡敦子, 石橋美輝, 旗野将貴, 國井泰人, 國井泰人, 日野瑞城, 泉竜太, 竹島明, 那波宏之, 柿田明美, 矢部博興

    日本生物学的精神医学会(Web)　41st　2019

  64. 栄養環境と遺伝的要因の組み合わせにより生じる新たな統合失調症モデルマウスの作製とその発症機序の解析

    平井志伸, 新井誠, 三輪秀樹, 國井泰人, 國井泰人, 日野瑞城, 長岡敦子, 矢部博興, 岡戸晴生

    統合失調症研究　9　(1)　2019

  65. 脳からみた精神科臨床-精神科ブレインバンクへの期待- 精神科臨床と死後脳とを結ぶ研究とは

    國井 泰人, 長岡 敦子, 日野 瑞城, 松本 純弥, 丹羽 真一, 矢部 博興

    精神神経学雑誌　114th　(2018特別号)　S326-S326　2018/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  66. Our Practice in Organizing Psychiatric Brain Bank: With Particular Emphasis on “Pre-Registered Donation System”

    國井泰人, 國井泰人, 松本純弥, 長岡敦子, 日野瑞城, 丹羽真一, 矢部博興

    精神神経学雑誌　120　(4)　269-276　2018/04

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  67. 統合失調症脳における慢性炎症関連分子のジェネティックニューロパソロジー

    和田明, 國井泰人, 日野瑞城, 松本純弥, 長岡敦子, 丹羽真一, 竹島明, 高橋均, 那波宏之, 柿田明美, 笠井清登, 矢部博興

    統合失調症研究　8　(1)　2018

  68. 精神疾患死後脳研究の最前線

    國井泰人, 日野瑞城, 松本純弥, 長岡敦子, 丹羽真一, 矢部博興

    統合失調症研究　8　(1)　2018

  69. 幻聴体験の分子メカニズムを考える 抗EGFR抗体,抗VEGF抗体の投与後に一過性の対話性幻聴を呈した1例 Peer-reviewed

    長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興

    精神医学　59　(12)　1141-1145　2017/12

    Publisher: (株)医学書院

    DOI： 10.11477/mf.1405205505 　

    ISSN： 0488-1281

    eISSN： 1882-126X

  70. 分子標的剤副作用例と死後脳研究に基づく、統合失調症における幻聴体験の分子メカニズムの考察

    長岡 敦子, 國井 泰人, 松本 純弥, 日野 瑞城, 矢部 博興, 宮川 哲平, 飯田 聡, 山崎 繁

    福島医学雑誌　67　(2)　101-102　2017/08

    Publisher: 福島医学会

    ISSN： 0016-2582

    eISSN： 2436-7826

  71. 精神科臨床と脳病理-精神科ブレインバンクへの期待- 生前登録制度に基づく精神疾患ブレインバンクの実践 当事者と研究者が協働する研究体制とは

    國井 泰人, 松本 純弥, 長岡 敦子, 日野 瑞城, 丹羽 真一, 矢部 博興

    精神神経学雑誌　113th　(2017特別号)　S410-S410　2017/06

    Publisher: (公社)日本精神神経学会

    ISSN： 0033-2658

  72. 死後脳内において高頻度にコピー数多型(CNV)が観察された統合失調症3症例の臨床的特徴について

    長岡敦子, 國井泰人, 松本純弥, 和田明, 和田明, 日野瑞城, 丹羽真一, 那波宏之, 高橋均, 柿田明美, 赤津裕康, 赤津裕康, 赤津裕康, 赤津裕康, 橋詰良夫, 橋詰良夫, 山本左近, 山本左近, 尾関祐二, 矢部博興

    統合失調症研究　7　(1)　85　2017/03/01

  73. 幻聴体験の分子メカニズムを考える 抗EGFR抗体,抗VEGF抗体の投与後に一過性の対話性幻聴を呈した1例

    長岡敦子, 國井泰人, 國井泰人, 松本純弥, 日野瑞城, 矢部博興

    精神医学　59　(12)　2017

    ISSN： 0488-1281

  74. 統合失調症患者死後脳前頭前皮質におけるAktシグナル伝達系蛋白質群の多項目同時測定

    日野瑞城, 國井泰人, 松本純弥, 和田明, 長岡敦子, 丹羽真一, 丹羽真一, 高橋均, 柿田明美, 赤津裕康, 赤津裕康, 橋詰良夫, 山本孝之, 矢部博興

    統合失調症研究　6　(1)　123　2016/03/01

  75. 統合失調症急性期におけるCOMT Val158Met遺伝子多型と臨床症状,aripiprazole治療反応性,血漿モノアミン代謝産物との関連

    金子春香, 金子春香, 三浦至, 野崎啓子, 堀越翔, 堀越翔, 渡辺研弥, 日野瑞城, 矢部博興

    日本臨床精神神経薬理学会プログラム・抄録集　26th　2016

  76. 統合失調症患者の前頭葉におけるタンパク質プロファイリングと変動する分子ネットワークの同定

    平山 未央, 國井 泰人, 松本 純弥, 和田 明, 日野 瑞城, 矢部 博興, 丹羽 真一, 近藤 豪, 瀬藤 光利, 大槻 純男

    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[2LBA087]-[2LBA087]　2015/12

    Publisher: (公社)日本生化学会

  77. 定量プロテオミクスを用いた統合失調症患者脳で発現変動する細胞内ネットワークの同定

    平山未央, 平山未央, 國井泰人, 松本純弥, 和田明, 日野瑞城, 矢部博興, 丹羽真一, 近藤豪, 瀬藤光利, 大槻純男, 大槻純男

    生体膜と薬物の相互作用シンポジウム講演要旨集　37th　2015

    ISSN： 0919-2131

  78. 統合失調症急性期におけるセロトニン2A受容体T102C遺伝子多型と臨床症状,aripiprazoleへの治療反応性,血漿モノアミン代謝産物濃度との関連

    野崎啓子, 三浦至, 江尻博紀, 八尋光晴, 大口春香, 堀越翔, 太田貴文, 阿部理, 渡辺研弥, 日野瑞城, 矢部博興

    日本臨床精神神経薬理学会プログラム・抄録集　25th　2015

  79. 全ゲノム遺伝子多型解析による統合失調症脳内ドパミン関連タンパク質発現プロファイルの予測

    國井泰人, 松本純弥, 日野瑞城, 和田明, 丹羽真一, 那波宏之, 横山裕一, 高橋均, 柿田明美, 矢部博興

    統合失調症研究　5　(1)　2015

  80. 統合失調症死後脳内タンパク質発現解析および発現量が変動した蛋白質の局在解析;質量分析法による網羅的及び標的指向的な二種の定量解析を用いて

    國井泰人, 大槻純男, 瀧澤陽平, 日野瑞城, 松本純弥, 和田明, 赤津裕康, 橋詰良夫, 山本孝之, 瀬藤光利, 寺崎哲也, 丹羽真一, 矢部博興

    統合失調症研究　4　(1)　98　2014/03

  81. 統合失調症でのドパミンD2受容体遺伝子多型による線条体ドパミンシステムへの影響

    松本純弥, 國井泰人, 三浦至, 日野瑞城, 和田明, 丹羽真一, 那波宏之, 坂井美和子, 染矢俊幸, 高橋均, 柿田明美, 矢部博興

    日本生物学的精神医学会誌　2014

    ISSN： 2186-6619

  82. 生前登録制度~当事者と研究者が作るインタラクティブな研究体制~

    國井泰人, 松本純弥, 日野瑞城, 和田明, 大沼裕美, 水本敬子, 矢部博興, 丹羽真一

    統合失調症研究　3　(1)　2013

  83. 質量顕微鏡法による統合失調症死後脳の脂質解析

    松本純弥, 杉浦悠毅, 由木大, 國井泰人, 堤弘次, 和田明, 日野瑞城, 赤津裕康, 橋詰良夫, 山本孝之, 佐藤慎二, 池本桂子, 瀬藤光利, 丹羽真一

    統合失調症研究　2　(1)　128　2012/03

  84. Additional activation of the phosphorylated myosin; the possible role of AA in vasospasms

    KATAYAMA TAKESHI, WATANABE MASARU, HINO MIZUKI, TANAKA HIDEYUKI, YOSHIYAMA SHINJI, NAKAMURA AKIO, KOHAMA KAZUHIRO

    J Pharmacol Sci　115　(Supplement 1)　159P-3d001956　2011/02

    ISSN： 1347-8613

  85. 筋ジストロフィーおよびその関連疾患の分子病態解明,診断法確立と薬物治療の開発に関する研究 骨格筋機能タンパクの分子病態学的研究

    依藤宏, 日野瑞城, 多鹿友喜, 佐藤真人, 高橋麻衣子, KHAIRANI Astrid Feinisa, 上野仁之, 村上徹

    筋ジストロフィーおよびその関連疾患の分子病態解明、診断法確立と薬物治療の開発に関する研究 平成20-22年度 総括研究報告書　2011

  86. 骨格筋単離筋線維に与える重イオンマイクロビーム照射の影響の形態学的検討 筋ジストロフィー研究への応用をめざして

    日野 瑞城, 和田 成一, 多鹿 友喜, 森村 吉博, 浜田 信行, 舟山 知夫, 坂下 哲哉, 柿崎 竹彦, 小林 泰彦, 依藤 宏

    日本放射線影響学会大会講演要旨集　50回　152-152　2007/11

    Publisher: (一社)日本放射線影響学会

    ISSN： 1347-8680

  87. Ultrastructural changes of isolated skeletal muscle fibers induced by heavy ion microbeam irradiation

    HINO Mizuki, WADA Seiichi, TAJIKA Yuki, MORIMURA Yoshihiro, HAMADA Nobuyuki, FUNAYAMA Tomoo, SAKASHITA Tetsuya, KAKIZAKI Takehiko, KOBAYASHI Yasuhiko, YORIFUJI Hiroshi

    The Japan Radiation Research Society Annual Meeting Abstracts　2007　342-342　2007

    Publisher: The Japanese Radiation Research Society

    DOI： 10.11513/jrrsabst.2007.0.342.0 　

    ISSN： 1347-8680

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    Muscular dystrophy is a heterogeneous group of hereditary diseases characterized by progressive muscle weakness. In many type of muscular dystrophy, microinjury of the plasma membrane is thought to result in muscle degeneration. However, no model system for inducing microinjury of the muscle plasma membrane and observing its resultant turnover has yet to be reported. To determine whether the muscle cell plasma membrane suffers microinjury and undergoes resultant turnover, we carried out target irradiation of isolated skeletal muscle fibers with heavy ion microbeams. <BR> The effects of heavy ion microbeams on muscle fibers isolated from wild type mouse skeletal muscles were examined by electron microscopy. The plasma membranes of heavy ion beam-irradiated areas of muscle fibers showed irregular protrusions and invaginations. In the cytoplasm, an irregular distribution of microfilaments was found near the plasma membrane.Sarcoplasmic reticula in the irradiated regions showed a distended appearance with flocculent material within the lumen.Many autophagic vacuoles could be seen at 7 min after irradiation. At 22 min, the vacuoles became more prominent and showed more variety.We also examined the ultrastructural changes of the muscle fibers of SJL mouse, which is a model for human dysferlinopathy (limb-girdle muscular dystrophy type 2B and Miyoshi muscular dystrophy),after irradiation. In addition to the structural changes similar to the wild type, several regions which were thought to be formerly constructed by myofibril, were occupied by the autophagic vacuoles and unidentified membranes. These observations suggest that heavy ion beam irradiation causes disruption of the cellular architecture and the autophagy is involved in removal of this disruption.

  88. Arachidonic acid enhances the hydrolysis step of ATPase by way of conformation change of the smooth muscle myosin Peer-reviewed

    T Katayama, M Hino, S Yoshiyama, H Tanaka, A Nakamura, K Kohama

    JOURNAL OF PHARMACOLOGICAL SCIENCES　100　263P-263P　2006

    ISSN： 1347-8613

  89. 分子シャペロンHsp27の紫外線致死抵抗性への関与

    和野 千枝子, 高橋 俊二, 日野 瑞城, 細谷 浩史, 喜多 和子, 鈴木 信夫

    生化学　74　(8)　1059-1059　2002/08

    Publisher: (公社)日本生化学会

    ISSN： 0037-1017

    eISSN： 2189-0544

  90. cdc2キナーゼは分裂期特異的にミオシン軽鎖キナーゼをリン酸化する

    菊池麻子, 村田(堀)麻希, 日野瑞城, 駒場繁, GERASHCHENKO B I, 細谷浩史

    日本分子生物学会年会プログラム・講演要旨集　22nd　1999

  91. HSP27 binds to tubulin and inhibits its polymerization

    MURATA-HORI Maki, KUROGI Kazuki, HINO Mizuki, OKUBO Masa-aki, NISHIKATA Takahito, HOSOYA Hiroshi

    21　496-496　1998/12/01

  92. Heat shock protein HSP27 locally exists in spindle fibre , and it inhibits the polymerization of tubulin.

    黒木和樹, 日野瑞城, 村田・堀麻希, 大久保昌明, 西方敬人, 細谷浩史

    日本動物学会大会予稿集　69th　1998

  93. Analysis of sialic acid binding site of tubulin by using anti sialic acid monoclonal antibody.

    日野瑞城, 高橋忠夫, 小阪敏和, 永井克孝, 細谷浩史

    日本動物学会中国四国支部会報　(48)　1996

    ISSN： 0285-385X

  94. Analysis of sialic acid binding site of tubulin by anti-sialic acid antibody. (Ministry of Education S)

    細谷浩史, 永井克孝, 日野瑞城

    糖鎖遺伝子とその生物機能 平成7年度 研究期間 平成5-8年度　1996

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Industrial Property Rights 3

  1. 束化アクチンを用いたマイクロアクチュエータ

    日野 瑞城, 小濱 一弘, 石川 良樹, 中村 彰男, 須齋 嵩, 大畠 昭子, 大岩 和弘

    Property Type: Patent

  2. 束化アクチンを用いたマイクロアクチュエータ

    日野 瑞城, 小濱 一弘, 石川 良樹, 中村 彰男, 須齋 嵩, 大畠 昭子, 大岩 和弘

    特許第4799007号

    Property Type: Patent

  3. 束化アクチンを用いたマイクロアクチュエータ

    日野瑞城

    Property Type: Patent

Research Projects 6

  1. Protein Palmitoylation and Schizophrenia Pathology: Insights from a Postmortem Brain Analysis

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2025/04/01 - 2028/03/31

  2. 統合失調症死後脳淡蒼球におけるストレス応答分子に着目した多階層的研究

    日野 瑞城, 矢部 博興, 三浦 至, 國井 泰人

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2021/04/01 - 2026/03/31

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    統合失調症の病態解明を目的とした最近の一連の画像研究は疾患群における淡蒼球の左側優位な体積増加を報告している。淡蒼球は頭部外傷や低酸素などの物理的ストレッサーに対して感受性が高いことから、統合失調症における淡蒼球体積増加は胎生期から発症に至るまでの脳の物理的・化学的・生物学的ストレッサーに対する応答の履歴を他領域よりも鋭敏に反映している現象であると考えた。この考えに基づき、統合失調症患者群と対照群の死後脳を比較して遺伝子発現レベル、タンパク質発現レベル、代謝産物レベル、組織学レベルで主にストレス応答に関与する分子に着目して解析する。 令和3年度は死後脳淡蒼球を用いて次世代シーケンサーによるmRNA発現解析を計画していたが、統合失調症例に関して mRNA のシーケンシングが完了した。これに対応する健常コントロールについては新潟大学脳研究所より提供を受けることで既にサンプルの選定等が進んでいるが、サンプリングには実際に立会い部位の確認を行うことを計画している。令和3年度はコロナ禍のため新潟大学に赴くことができなかったが、出張が可能となり次第サンプリングとmRNAシーケンシングを行う準備ができている。 治療抵抗性統合失調症に対して唯一効果があるとされるクロザピンについては DRD2などのモノアミン受容体以外にも薬理学的な標的があると考えらていたが、プロリンロッド法を用いてこれをスクリーニングし、結果を論文投稿した。

  3. Molecular profiling of the Pro to Glu pathway in postmortem brains with schizophrenia

    Kunii Yasuto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2019/04/01 - 2022/03/31

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    We examined the protein expressions of Aldehyde dehydrogenase 4 family member A1 (ALDH4A1) in the prefrontal cortex (PFC; BA10) and superior temporal gyrus(STG; BA22) using postmortem brain sample sets from schizophrenia, bipolar disorder and healthy controls. ALDH4A1 expression was significantly higher in the schizophrenia and bipolar disorder groups in the PFC and STG. We also found that SNPs in the P5C synthetase gene (rs10882639) and prolidase (PEPD) gene (rs33823,rs153508) predicted ALDH4A1 expression in PFC in an allele-dependent manner. In addition, we investigated protein expression levels of proline oxidase (PRODH) and PEPD, which are part of the pathway that metabolizes proline to glutamate, in the same sample set, and PRODH expression in STG was significantly lower in schizophrenia. Incidentally, we found that no SNPs had a cis-acting effect on any protein expressions.

  4. Genetic neuropathological investigation of the molecules in chronic inflammation in the postmortem brains from patients with schizophrenia.

    WADA AKIRA, Yabe Hirooki, Kunii Yasuto, Hino Mizuki, Matsumoto Jyunya, Nagaoka Atsuko, Niwa Shin-ichi, Takeshima Akari, Takahashi Hitoshi, Nawa Hiroyuki, Kakita Akiyoshi, Kakiuchi Chihiro, Kasai Kiyoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: The University of Tokyo

    2016/04/01 - 2018/03/31

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    The present study aimed to elucidate part of the mechanism of schizophrenia onset using the postmortem brains. Using the Luminex assay, the expression levels of molecules involved in immunity and chronic inflammation were measured in postmortem brains from patients with schizophrenia. The data obtained from the postmortem brains from patients with schizophrenia were also analyzed regarding the relationship between each molecular level and clinical profile. The following results were obtained. 1) The schizophrenia group had lower interferon-inducible protein (IP)-10 mass/mg total protein (pg/mg) compared to healthy controls (p=0.012). 2) The schizophrenia group had lower IL-17A protein mass/mg total protein (pg/mg) compared to healthy controls (p=0.003). 3) Spearman's rank correlation analysis of the relationships of IP-10 and IL-17A protein mass/mg total protein with mean antipsychotic dose over the 3 months antemortem found a positive correlation for IP-10 (p=0.032).

  5. The analysis of molecular expressions of postmortem brains with schizophrenia: genetic neuropathology

    Kunii Yasuto, Yabe Hirooki, Matsumoto Junya, Hino Mizuki, Wada Akira, Niwa Shin-ichi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Fukushima Medical University

    2015/04/01 - 2018/03/31

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    We performed genetic neuropathology as follows:1) the examination of protein expressions for members of the Akt signaling pathway using multiplex fluorescent bead based immunoassays in the prefrontal cortex and the nucleus accumbens of postmortem brains from 20 cases with schizophrenia, and association of these expressions with genetic variants; 2) adding 6 bipolar cases, same examination of DARPP-32 and calcineurin; 3) association study between the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene and DARPP-32 expression in the striatum of schizophrenia; 4) the examination of the expressions of molecules involved in immunity and chronic inflammation using the Luminex assay in the superior temporal gyrus of post mortem brains from 60 cases including schizophrenia, and association of these expressions with genetic variants.

  6. Analysis of modulatory effects of Pin1 on DARPP-32 function.

    HINO MIZUKI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Fukushima Medical University

    2012/04/01 - 2016/03/31

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    DARPP-32, which is thought to be involved in schizophrenia, controls the protein phosphatase (PP1) and protein kinase A (PKA) in a phosphorylation-dependent manner, and its phosphorylation level is regulated by dopaminergic and glutaminergic stimulations. . We hypothesize that Pin1 isomerizes phosphorylated DARPP-32 and controls the inhibitory activity of DARPP-32 on PP1 and PKA. We conducted biochemical analysis to examine the hypothesis. We also made in silico analysis to predict the common binding partners of DARPP-32 and Pin1.

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