Details of the Researcher

PHOTO

Hirotaka Nakatsuji
Section
Institute of Multidisciplinary Research for Advanced Materials
Job title
Assistant Professor
Degree

  • 博士（工学）（京都大学）

  • 修士（工学）（京都大学）

Research History 3

  • 2023/04 - Present
    Tohoku University　Institute of Multidisciplinary Research for Advanced Materials Materials-Measurement Hybrid Research Center　Assistant professor

  • 2021/04 - 2023/03
    コンポン研究所　東東京研究室 東北大学分室　研究員

  • 2017/04 - 2021/03
    大阪大学大学院工学研究科　先端細胞制御化学(TOPPAN)共同研究講座　特任研究員（常勤）

Education 2

  • 京都大学大学院　工学研究科　分子工学専攻

    2011/04 - 2017/03

  • Kyoto University　Faculty of Engineering

    2007/04 - 2011/03

Professional Memberships 3

  • 日本バイオマテリアル学会

  • 高分子学会

  • 日本化学会

Research Interests 4

  • 光機能性材料

  • ドラッグデリバリー

  • バイオマテリアル

  • ナノマテリアル

Research Areas 3

  • Nanotechnology/Materials / Inorganic compounds/materials chemistry /

  • Nanotechnology/Materials / Polymer chemistry /

  • Nanotechnology/Materials / Nanobioscience /

Papers 21

  1. Photodynamic antimicrobial activity of polydiacetylene crystal nanostructure against E. coli

    Mohammad Oves, Ryuju Suzuki, Hirotaka Nakatsuji, Yoshitaka Koseki, Sanjay Kumar, Kouki Oka, Hitoshi Kasai

    MRS Communications　14　(6)　1307-1312　2024/08/08

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1557/s43579-024-00622-8 　

    eISSN： 2159-6867

  2. Combined substituent number utilized machine learning for the development of antimicrobial agent

    Keitaro Yamauchi, Hirotaka Nakatsuji, Takaaki Kamishima, Yoshitaka Koseki, Masaki Kubo, Hitoshi Kasai

    Scientific Reports　14　(1)　2024/02/19

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-53888-2 　

    eISSN： 2045-2322

    More details Close

    Abstract The utilization of machine learning has a potential to improve the environment of the development of antimicrobial agents. For practical use of machine learning, it is important that the conversion of molecules information to an appropriate descriptor because too informative descriptor requires enormous computation time and experiments for gathering data, whereas a less informative descriptor has problems in validity. In this study, we utilized a descriptor only focused on substituent. The type and the position of substituents on the molecules that have a 4-quinolone structure (11,879 compounds) were converted to the combined substituent number (CSN). While the CSN does not include information on the detailed structure, physical properties, and quantum chemistry of molecules, the prediction model constructed by machine learning of CSN indicated a sufficient coefficient of determination (0.719 for the training dataset and 0.519 for the validation dataset). In addition, this CSN can easily construct the unknown molecules library which has a relatively consistent structure by recombination of substituents (32,079,318 compounds) and screening of them. The validity of the prediction model was also confirmed by growth inhibition experiments for E. coli using the model-suggested molecules and commercially available antimicrobial agents.

  3. Carrier-free nano-prodrugs for minimally invasive cancer therapy

    Keita Tanita, Yoshitaka Koseki, Sanjay Kumar, Farsai Taemaitree, Asuka Mizutani, Hirotaka Nakatsuji, Ryuju Suzuki, Anh Thi Ngoc Dao, Fumiyoshi Fujishima, Hiroshi Tada, Takanori Ishida, Ken Saijo, Chikashi Ishioka, Hitoshi Kasai

    Nanoscale　16　(32)　15256-15264　2024

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d4nr01763c 　

    ISSN： 2040-3364

    eISSN： 2040-3372

    More details Close

    SNC4DC, a dimer of SN-38 derivatives, has been synthesized. SNC4DC nanoparticles called nano-prodrugs are internalized into the cell and dissociate, and the active SN-38 is released after reduction of the S–S bond in the presence of GSH occurs.

  4. Ir-Catalyzed Cascade Reaction Promotes the Formation of Geometrically Selective Enones from Bis-allyl Alcohols Peer-reviewed

    Takaaki Kamishima, Yoshitaka Koseki, Hirotaka Nakatsuji, Sanjay Kumar, Keita Tanita, Hitoshi Kasai

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY　2022　(43)　2022/11

    DOI： 10.1002/ejoc.202201002 　

    ISSN： 1434-193X

    eISSN： 1099-0690

  5. Total synthesis and antimicrobial evaluation of (+)-hygrophorone B-12 and its analogues Peer-reviewed

    Takaaki Kamishima, Masato Suzuki, Koichi Narita, Yoshitaka Koseki, Toshiyuki Nonaka, Hirotaka Nakatsuji, Hideo Hattori, Hitoshi Kasai

    SCIENTIFIC REPORTS　12　(1)　2022/05

    DOI： 10.1038/s41598-022-11608-8 　

    ISSN： 2045-2322

  6. Conversion of 2,5-Bis(hydroxymethyl)furan to Highly Oxidized Cyclopentenones under Catalyst-free Conditions in Water

    Hirotaka Nakatsuji, Takaaki Kamishima, Toshiyuki Nonaka, Yoshitaka Koseki, Hitoshi Kasai

    CHEMISTRY LETTERS　51　(5)　497-499　2022/05

    DOI： 10.1246/cl.220027 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  7. Development of temperature dependent oxygen releasable nanofilm by modulating oxidation state of myoglobin. International-journal Peer-reviewed

    Daisuke Tomioka, Hirotaka Nakatsuji, Shigeru Miyagawa, Yoshiki Sawa, Michiya Matsusaki

    Chemical communications (Cambridge, England)　57　(42)　5131-5134　2021/05/25

    DOI： 10.1039/d1cc01545a 　

    More details Close

    Controlled release of oxygen from myoglobin was achieved by modulating autoxidation of oxymyoglobin using ascorbic acid as a reductant by temperature variation. Long-term storage, prompt release and re-storage of oxygen were also available with this system. Furthermore, 20 nm thick nanofilms composed of oxymyoglobin and type I collagen containing ascorbic acid could successfully show autoxidation of oxymyoglobin in response to environmental temperature. The ultrathin nanofilms will be useful as oxygen-controlled releasable scaffolds for tissue engineering application.

  8. Cancer-microenvironment triggered self-assembling therapy with molecular blocks

    Hirotaka Nakatsuji, Yudai Shioji, Noboru Hiraoka, Yuta Okada, Natsuko Kato, Sayaka Shibata, Ichio Aoki, Michiya Matsusaki

    Materials Horizons　8　(4)　1216-1221　2021

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d0mh02058c 　

    ISSN： 2051-6347

    eISSN： 2051-6355

    More details Close

    <p>Molecular blocks (4-MB) were designed to circulate as a single molecule or as a few molecules in blood vessels and self-assemble in response to a tumor specific conditions, as a cancer therapeutic agent.</p>

  9. Enhancing Photostability of a Coumarin Dye by Self‐inclusion into a Cyclodextrin Cavity in Aqueous Solution and Living Cells Peer-reviewed

    Hajime Shigemitsu, Keigo Matsuda, Tadashi Mori, Hirotaka Nakatsuji, Michiya Matsusaki, Toshiyuki Kida

    Asian Journal of Organic Chemistry　9　(12)　2112-2115　2020/12

    DOI： 10.1002/ajoc.202000365 　

    ISSN： 2193-5807

    eISSN： 2193-5815

  10. Preparation of Extracellular Matrix Paper and Construction of Multi‐Layered 3D Tissue Model

    Hirotaka Nakatsuji, Shiro Kitano, Shinji Irie, Michiya Matsusaki

    Current Protocols in Cell Biology　88　(1)　2020/08/10

    Publisher: Wiley

    DOI： 10.1002/cpcb.112 　

    ISSN： 1934-2500

    eISSN： 1934-2616

  11. Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles. International-journal Peer-reviewed

    Tomohiro Nobeyama, Kazuki Shigyou, Hirotaka Nakatsuji, Hiroshi Sugiyama, Naoko Komura, Hiromune Ando, Tsutomu Hamada, Tatsuya Murakami

    Langmuir : the ACS journal of surfaces and colloids　2020/06/05

    DOI： 10.1021/acs.langmuir.0c00049 　

    More details Close

    Liquid-ordered (Lo) phase domains, a cholesterol-rich area on lipid bilayers, have attracted significant attention recently due to their relevance to lipid rafts, the formation/collapse of which is associated with various kinds of information exchange through the plasma membrane. Here, we demonstrate that the formation/collapse of Lo phase domains in cell-sized lipo-somes, i.e., giant unilamellar vesicles (GUVs), can be controlled with bioactive plasmonic nanoparticles and light. The na-noparticles were prepared by the surface modification of gold nanorods (AuNRs) using a cationized mutant of high-density lipoprotein (HDL), which is a natural cholesterol transporter. Upon the addition of surface-engineered AuNRs to GUVs with the mixed domains of Lo and liquid-disorder (Ld) phases, the Lo domains collapsed and solid ordered (So) phase domains were formed. The reverse phase transition was achieved photothermally, with the AuNRs loaded with cholesterol. During these transitions, the AuNRs appeared to be selectively localized on the less fluidic domain (Lo or So) in the phase-mixed GUVs. These results indicate that the phase transitions occur through the membrane binding of the AuNRs followed by spontaneous/photothermal transfer of cholesterol between the AuNRs and GUVs. Our strategy to develop bioactive AuNRs potentially enables spatiotemporal control of the formation/collapse of lipid rafts in living cell.

  12. Extracellular Matrix Microfiber Papers for Constructing Multilayered 3D Composite Tissues

    Hirotaka Nakatsuji, Michiya Matsusaki

    ACS BIOMATERIALS SCIENCE & ENGINEERING　5　(11)　5610-5614　2019/11

    DOI： 10.1021/acsbiomaterials.9b00090 　

    ISSN： 2373-9878

  13. Aggregation-Induced Singlet Oxygen Generation: Functional Fluorophore and Anthrylphenylene Dyad Self-Assemblies Peer-reviewed

    Sooyeon Kim, Yang Zhou, Norimitsu Tohnai, Hirotaka Nakatsuji, Michiya Matsusaki, Mamoru Fujitsuka, Mikiji Miyata, Tetsuro Majima

    Chemistry - A European Journal　24　(3)　636-645　2018/01/12

    DOI： 10.1002/chem.201703686 　

    ISSN： 1521-3765 0947-6539

  14. DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy Peer-reviewed

    Tomoya Yata, Yuki Takahashi, Mengmeng Tan, Hirotaka Nakatsuji, Shozo Ohtsuki, Tatsuya Murakami, Hiroshi Imahori, Yuka Umeki, Tomoki Shiomi, Yoshinobu Takakura, Makiya Nishikawa

    BIOMATERIALS　146　136-145　2017/11

    DOI： 10.1016/j.biomaterials.2017.09.014 　

    ISSN： 0142-9612

    eISSN： 1878-5905

  15. Surface chemistry for cytosolic gene delivery and photothermal transgene expression by gold nanorods Peer-reviewed

    Hirotaka Nakatsuji, Kelly Kawabata Galbraith, Junko Kurisu, Hiroshi Imahori, Tatsuya Murakami, Mineko Kengaku

    SCIENTIFIC REPORTS　7　(1)　4694　2017/07

    DOI： 10.1038/s41598-017-04912-1 　

    ISSN： 2045-2322

  16. Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and F-19 Magnetic Resonance Imaging Peer-reviewed

    Tomohiro Higashino, Hirotaka Nakatsuji, Ryosuke Fukuda, Haruki Okamoto, Hirohiko Imai, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Nikolai V. Tkachenko, Mitsuru Hashida, Tatsuya Murakami, Hiroshi Imahori

    CHEMBIOCHEM　18　(10)　951-959　2017/05

    DOI： 10.1002/cbic.201700071 　

    ISSN： 1439-4227

    eISSN： 1439-7633

  17. Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles Peer-reviewed

    Hirotaka Nakatsuji, Tomohiro Numata, Nobuhiro Morone, Shuji Kaneko, Yasuo Mori, Hiroshi Imahori, Tatsuya Murakami

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION　54　(40)　11725-11729　2015/09

    DOI： 10.1002/anie.201505534 　

    ISSN： 1433-7851

    eISSN： 1521-3773

  18. Mesoscopic Metal Nanoparticles Doubly Functionalized with Natural and Engineered Lipidic Dispersants for Therapeutics Peer-reviewed

    Tatsuya Murakami, Hirotaka Nakatsuji, Nobuhiro Morone, John E. Heuser, Fumiyoshi Ishidate, Mitsuru Hashida, Hiroshi Imahori

    ACS NANO　8　(7)　7370-7376　2014/07

    DOI： 10.1021/nn5024818 　

    ISSN： 1936-0851

    eISSN： 1936-086X

  19. Exclusive Photothermal Heat Generation by a Gadolinium Bis(naphthalocyanine) Complex and Inclusion into Modified High-Density Lipoprotein Nanocarriers for Therapeutic Applications Peer-reviewed

    Simon Mathew, Tatsuya Murakami, Hirotaka Nakatsuji, Haruki Okamoto, Nobuhiro Morone, John E. Heuser, Mitsuru Hashida, Hiroshi Imahori

    ACS NANO　7　(10)　8908-8916　2013/10

    DOI： 10.1021/nn403384k 　

    ISSN： 1936-0851

    eISSN： 1936-086X

  20. Mechanism of Cell Interactions with Water-Dispersed Carbon Nanohorns Peer-reviewed

    Tatsuya Murakami, Masashi Nakatani, Masahiro Kokubo, Hirotaka Nakatsuji, Mami Inada, Hiroshi Imahori, Masako Yudasaka, Sumio Iijima, Kunihiro Tsuchida

    NANOSCIENCE AND NANOTECHNOLOGY LETTERS　5　(3)　402-407　2013/03

    DOI： 10.1166/nnl.2013.1544 　

    ISSN： 1941-4900

    eISSN： 1941-4919

  21. Photodynamic and Photothermal Effects of Semiconducting and Metallic-Enriched Single-Walled Carbon Nanotubes Peer-reviewed

    Tatsuya Murakami, Hirotaka Nakatsuji, Mami Inada, Yoshinori Matoba, Tomokazu Umeyama, Masahiko Tsujimoto, Seiji Isoda, Mitsuru Hashida, Hiroshi Imahori

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　134　(43)　17862-17865　2012/10

    DOI： 10.1021/ja3079972 　

    ISSN： 0002-7863

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Misc. 4

  1. わこうどの声 ナノ・マイクロ多孔炭素材料の新しい 応用展開を目指して

    中辻 博貴

    炭素　2024　(305)　46-46　2024/01

    DOI： 10.7209/tanso.2024.66 　

  2. Catalyst-free conversion of 2,5-bis (hydroxymethyl) furan into cyclopentenone derivatives in water

    中辻博貴, 神島尭明, 野中利之, 小関良卓, 笠井均

    日本化学会春季年会講演予稿集(Web)　102nd　2022

  3. 体の中の構造を再現するための三次元培養の挑戦あれこれ

    中辻博貴

    生物工学会誌　96　(7)　2018

    ISSN： 0919-3758

  4. Optical Control of the Structure and Function of Lipid Bilayers by Plasmonic Nanomaterials

    村上達也, 村上達也, 中辻博貴

    レーザー研究　45　(11)　2017

    ISSN： 0387-0200

Books and Other Publications 1

  1. Nanomedicines for Effective Cancer Therapy

    Hitoshi Kasai, Hiroshi Uji-i, Johan Hofkens

    Springer　2024/10

    ISBN: 9789819752881

Presentations 25

  1. Biocompatible and aqueous-stable honeycomb monolith for cell culture scaffold

    Tian Mengli, Minghao Liu, Hirotaka Nakatsuji, Hitoshi Kasai, Hirotomo Nishihara

    2024/12/03

  2. Multifunctional Carbon Monolith with Enhanced Strength and Low Pressure Loss

    Minghao Liu, Hirotaka Nakatsuji, Rui Tang, Zheng-Ze Pan, Hirotomo Nishihara

    2024/12/02

  3. ジアルデヒドで架橋した多孔性フラーレンポリマーの表面機能

    中辻 博貴, 高月 瑛, 吉井 丈晴, 道信 剛志, 藤木 翔吾, 笹野 祐介, 岩淵 好治, 西原 洋知

    吸着－ゼオライト合同研究発表会（第37回日本吸着学会研究発表会、第40回ゼオライト研究発表会）　2024/12/03

  4. elective amino functionalization of the inner wall of giant hollow carbon tubes

    Peng Wang, Hirotaka Nakatsuji, Hitoshi Kasai, Hirotomo Nishihara

    2024/11/27

  5. Size-selective separation of exosomes using porous electrodes

    Hiroshi Yuzawa, Hongyu Liu, Pan Zhengze, Hirotaka Nakatsuji, Yoshikazu Tanaka, Takao Yasui, Hirotomo Nishihara

    Tohoku University & National Taipei University of Technology 2024 Joint Symposium (7th TU-TaipeiTech JS )　2024/11/26

  6. Biocompatible honeycomb monolith as a scaffold for parallelly aligned tissue regeneration

    Mengli Tian, Minghao Liu, Hirotaka Nakatsuji, Hirotomo Nishihara

    2024/10/28

  7. Dispersibility and cytotoxicity of size-controllable giant hollow carbon tubes modified by surfactant

    Peng Wang, Hirotaka Nakatsuji, Hirotomo Nishihara

    2024/10/28

  8. Aqueous dispersibility and cytotoxicity of surfactant adsorbed giant hollow carbon tubes

    Peng Wang, Hirotaka Nakatsuji, Hirotomo Nishihara

    The 9th Pacific Basin Conference on Adsorption Science and Technology　2024/09/26

  9. Biocompatible honeycomb monolith with micro-meter-scale straight channels as cell culture scaffold

    Mengli Tian, Hirotaka Nakatsuji, Hirotomo Nishihara

    The 9th Pacific Basin Conference on Adsorption Science and Technology　2024/09/26

  10. High Mechanical Strength Carbonized Monolith for Rapid Water Filtration

    Minghao Liu, Hirotaka Nakatsuji, Rui Tang, Zheng-Ze Pan, Mao Ohwada, Hirotomo Nishihara

    The 9th Pacific Basin Conference on Adsorption Science and Technology　2024/09/26

  11. Functions of solid nanoporous fullerene polymer cross linked with dialdehydes

    Hirotaka Nakatsuji, Akira Takatsuki, Takeharu Yoshii, Tsuyoshi Michinobu, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi, Hirotomo Nishihara

    The 9th Pacific Basin Conference on Adsorption Science and Technology　2024/09/26

  12. Development of porous electrodes for size separation of exosomes

    H. Yuzawa, L. Hongyu, Z. Pan, H. Nakatsuji, Y. Tanaka, T. Yasui, H. Nishihara

    AtomDeC4th International Symposium　2024/08/01

  13. Inner surface selective amino functionalization of giant hollow carbon tubes

    Peng Wang, Hirotaka Nakatsuji, Hirotomo Nishihara

    AtomDeC4th International Symposium　2024/08/02

  14. Biocompatible honeycomb monolith as muscle tissue engineering scaffold

    Mengli Tian, Hirotaka Nakatsuji, Hirotomo Nishihara

    AtomDeC4th International Symposium　2024/08/02

  15. High-Strength and Low-Density Carbon Monolith for Rapid Water Purification

    Minghao Liu, Hirotaka Nakatsuji, Rui Tang, Zheng-Ze Pan, Mao Ohwada, Hirotomo Nishihara

    AtomDeC4th International Symposium　2024/08/02

  16. エクソソームをサイズ選択的に捕捉する新規多孔性電極の開発

    湯澤浩, 中辻博貴, 田中良和, 正, 西原洋知

    第26回先端研究発表会　2024/07/26

  17. Biocompatible honeycomb monolith containing β-tricalcium phosphate for bone tissue engineering scaffold

    Mengli, Tian, Hirotaka, Nakatsuji, Hirotomo, Nishihara

    2023/12/07

  18. Enhanced Structural Integrity of Porous Carbon Monoliths with Aligned Microchannels

    Minghao, Liu, Rui, Tang, Mao, Ohwada, Hirotaka, Nakatsuji, Zheng-Ze, Pan, Hirotomo, Nishihara

    2023/11/29

  19. Biocompatibility of size-controllable giant hollow carbon tubes

    Wang, Peng, Hirotaka, Nakatsuji, Hitoshi, Kasai, Hirotomo, Nishihara

    2023/11/29

  20. Size-controllable Giant Hollow Carbon Tubes for bio application

    Peng, Wang, Hirotaka, Nakatsuji, Hirotomo, Nishihara

    2023/11/07

  21. Fabrication of Highly Permeable Carbon Honeycomb Monolith with Micro-Chennel Sizes

    Minghao Liu, Rui Tang, Mao Ohwada, Hirotaka Nakatsuji, Zheng-Ze Pan, Hirotomo Nishihara

    2023/11/07

  22. Biocompatible honeycomb monoliths with micro-meter-scale straight channels

    Mengli, Tian, Hirotaka, Nakatsuji, Hirotomo, Nishihara

    International Syposium for the 80th Anniversary of Tohoku Branch of the Chemical Society of Japan　2023/09/08

  23. Mechanically Tough Carbon Monoliths with Aligned Micro-Channels

    Minghao, Liu, Rui, Tang, Mao, Ohwada, Hirotaka, Nakatsuji, Zheng-Ze, Pan, Hirotomo, Nishihara

    International Syposium for the 80th Anniversary of Tohoku Branch of the Chemical Society of Japan　2023/09/10

  24. Aqueous dispersion stability and biocompatibility of size-controllable giant hollow carbon tubes modified by surfactant

    Peng, Wang, Hirotaka, Nakatsuji, Hirotomo, Nishihara

    International Syposium for the 80th Anniversary of Tohoku Branch of the Chemical Society of Japan　2023/09/08

  25. Biocompatibility of size-controllable giant hollow carbon tubes modified by surfactant

    Peng, Wang, Hirotaka, Nakatsuji, Hirotomo, Nishihara

    2023/09/04

Show all Show first 5

Industrial Property Rights 2

  1. 細胞培養用シート並びに三次元組織体及びその製造方法

    北野 史朗, 入江 新司, 松▲崎▼ 典弥, 中辻 博貴

    Property Type: Patent

  2. 細胞構造体及びその製造方法

    北野 史朗, 入江 新司, 松▲崎▼ 典弥, 中辻 博貴, 小倉 正恒, 斯波 真理子

    Property Type: Patent

Research Projects 1

  1. 高密度な細胞外マトリックスを持つ革新的な正常・動脈硬化三次元血管壁モデルの創製 Competitive

    中辻 博貴

    Offer Organization: 日本学術振興会

    System: 研究活動スタート支援

    2017/08 - 2019/03

Teaching Experience 1

  1. Solid State Materials Design　Tohoku University

Social Activities 1

  1. Kyoto University ICeMS Leraning Lounge

    2016/08/03 - 2016/08/03

Media Coverage 1

  1. 京大、遺伝子を細胞内に運び数秒の光照射で発現させる金ナノ粒子技術を開発

    日本経済新聞

    2017/07

    Type: Newspaper, magazine