Details of the Researcher

PHOTO

That Loi Ton
Section
Graduate School of Engineering
Job title
Assistant Professor
Degree

  • Doctor of Engineering

e-Rad No.
90844499
Profile

Currently, I serve as an Assistant Professor at Tohoku University. My work has consistently focused on the synthesis and applications of magnetic nanoparticles (MNPs), with particular emphasis on gold–iron oxide (Au–Fe₃O₄) heterodimer nanoparticles.

These nanoparticles show great potential for advanced medical technologies such as magnetic hyperthermia, magneto-optical diagnostics, and ultrasensitive biosensing. Through the integration of nanotechnology and biomedical applications, my goal is to contribute to the realization of next-generation healthcare solutions.

In addition, I have been engaged in the development of GHz-range high-frequency magnetic sensing technologies and in studies on nanoparticle heating control using ferromagnetic resonance (FMR). These efforts aim to establish core technologies for ultra-early cancer diagnosis and highly efficient therapeutic systems. My research also envisions future integration with bio-sensors and medical devices based on microfabrication processes, bridging fundamental research with applied and practical implementations.

My main research fields include:

  • Synthesis of functional magnetic nanoparticles and development of diagnostic, therapeutic, and biosensing technologies
  • Design and biomedical applications of multifunctional Au–Fe₃O₄ heterodimer nanoparticles with enhanced magneto-optical properties
  • Development of GHz-range thin-film magnetic sensors and their applications to biomagnetic detection
  • Construction of magnetic hyperthermia systems and highly sensitive biomarker detection technologies using ferromagnetic resonance (FMR)
  • Creation of next-generation medical devices through the fusion of nanotechnology, biomedical applications, and MEMS technologies

Researcher Project (PI) KAKENHI https://nrid.nii.ac.jp/en/nrid/1000090844499/

Research History 4

  • 2019/04 - Present
    Tohoku University　Graduate School of Engineering　Assistant Professor

  • 2016/04 - 2019/03
    Japan Society for the Promotion of Science　JSPS Research Fellowship for Young Scientists DC1

  • 2018/06 - 2019/03
    Akita University　Graduate School of Engineering Science　Research Assistant

  • 2017/06 - 2018/03
    Akita University　Graduate School of Engineering Science　Research Assistant

Education 7

  • Akita University　Graduate School of Engineering Science　Department of Integrated Engineering Science (Doctor's Degree Program)

    2016/04 - 2019/03

  • Akita University　Graduate School of Engineering and Resource Science　Department of Computer Science and Engineering (Master's Degree Program)

    2014/04 - 2016/03

  • Akita University　Faculty of Engineering and Resource Science　Department of Computer Science and Engineering

    2012/04 - 2014/03

  • National Institute of Technology Wakayama College　Department of Electrical and Information

    2009/04 - 2012/03

  • Tokyo Japanese Language Education Center　University Preparatory Course　Natural Science

    2008/04 - 2009/03

  • Danang University of Technology　Department of Electronic Telecommunication

    2006/09 - 2008/03

  • Hue University of Sciences　Gifted High School　Faculty of Mathematics

    2003/09 - 2006/06

Show all Show first 5

Committee Memberships 6

  • Spinics Kenkyukai　Secretary, Planning

    2024/04 - Present

  • Institute of Electrical Engineers of Japan　Technical Committee on Magnetics

    2021/03 - Present

  • 5th International Symposium on Advanced Magnetic Materials and Applications (ISAMMA) August 4 to 7, 2024 in Quang Binh, Vietnam　Program Committee

    2024/08 - 2024/08

  • 2nd Global Summit and Expo on Magnetism and Magnetic Materials (GSEMMM2022, June 13-15, 2022, Copenhagen, Denmark)　Committee member & Invited speaker

    2022/06 - 2022/06

  • Spinics Kenkyukai　Secretary

    2019/04 - 2022/03

  • IEEE Magnetics Society Sendai/Sapporo Joint Chapter　Treasurer

    2019/04 - 2021/03

Show all ︎Show first 5

Professional Memberships 5

  • THE MAGNETICS SOCIETY OF JAPAN

    2019/04 - Present

  • IEEE Magnetics Society

    2018/01 - Present

  • Institute of Electrical and Electronics Engineers (IEEE)

    2017/01 - Present

  • JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING

    2019/04 - Present

  • Institute of Electrical Engineers of Japan (IEEJ)

    2017/03 - Present

Research Interests 6

  • Micro- and Nanotechnology

  • High-Frequency Magnetic Field Measurement

  • Biomedical Signal Measurement

  • High-Sensitivity Thin-Film Magnetic Sensor

  • Plasmonic–Magnetic Au–Fe₃O₄ Nanoparticles

  • Magnetic Hyperthermia

Research Areas 4

  • Nanotechnology/Materials / Nano/micro-systems /

  • Nanotechnology/Materials / Nanobioscience /

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Measurement engineering /

  • Life sciences / Medical systems /

Awards 19

  1. Student Presentation Award

    2024/11　IEEE Magnetics Society Sendai/Sapporo Joint Chapter　Magnetic heating properties of hollow Fe3O4 particles with magnetic vortex structure

  2. MSJ Paper Encouragement Award, The Magnetic Society of Japan, 2024

    2024/09　Magnetics Society of Japan　Magnetic Heating Properties of Hollow Fe3O4 Nanoparticles with Magnetic Vortex Structure

  3. Student Presentation Award (Sakurai Award), The Magnetic Society of Japan, 2024

    2024/09　Magnetics Society of Japan　Magnetic heating properties of hollow Fe3O4 particles with magnetic vortex structure

  4. Excellent Presentation Award (Division A)

    2024/08　Institute of Electrical Engineers of Japan　Method for Measuring Magnetic Susceptibility of Magnetic Nanoparticles up to 67 GHz

  5. MSJ Paper Encouragement Award, The Magnetic Society of Japan, 2023

    2023/06　Magnetics Society of Japan　Method for Rapid Detection of Bacteria Using Magnetic Nanoparticle Aggregates

  6. Student Presentation Award (Sakurai Award), The Magnetic Society of Japan, 2022

    2022/09　Magnetics Society of Japan　Magnetic nanoparticle-based bacterial detection via switching magnetic field response

  7. Research Encouragement Award from the Magnetics Technical Committee, The Institute of Electrical Engineers of Japan (IEEJ)

    2019/12　Institute of Electrical Engineers of Japan　High-Frequency Permeability Measurement of Magnetic Thin Films Using a Microstrip Probe

  8. Paper Encouragement Award of the Magnetics Society of Japan (The 43rd Annual Conference of the Magnetics Society of Japan (Kyoto, Japan))

    2019/09　Magnetics Society of Japan　Coplanar line type thin film magnetic field sensor with flip chip bonding

  9. Student Excellence Award for Fiscal Year 2018

    2019/03　Akita University

  10. 「Poster Presentation Award」

    2018/11　3rd International Workshop on Magnetic Bio-Sensing

  11. Best Paper Award for Fiscal Year 2017

    2018/04　Institute of Electrical Engineers of Japan - IEEJ Tohoku Branch

  12. Student Award for Fiscal Year 2017

    2018/03　Akita University

  13. Excellent Paper Award

    2017/10　8th International Conference on Materials Engineering for Resources (ICMR2017 AKITA)

  14. Advances in Magnetism Award Finalists

    2020/10　(Paper) A simple and rapid detection system for oral bacteria in liquid phase for point-of-care diagnostics using magnetic nanoparticles (1st author) (https://aip.scitation.org/adv/info/award)

  15. Top Downloaded Paper 2018-2019 (in IEEJ Transactions on Electrical and Electronic Engineering)

    2020/05　(Paper) Magnetic field dependence of heating property of resovist® for magnetic hyperthermia (1st author)

  16. SATOYO International Student Scholarship（～March 2019） (Decline)

    2016/04　SATOYO International scholarship foundation

  17. JSPS Research Fellowships for Young Scientists DC1（～March 2019）

    2016/04　Japan Society for the Promotion of Science

  18. DOCOMO International Student Scholarship (～ March 2016)

    2014/04　Japan Educational Exchanges and Services (JEES)

  19. JAPANESE GOVERNMENT (MEXT) Scholarship (～March 2014)

    2008/04　Ministry of Education, Culture, Sports, Science and Technology

Show all ︎Show 5

Papers 60

  1. Rapid detection of Fusobacterium nucleatum in saliva using magnetic flux change Peer-reviewed

    Shin Yabukami, Amane Ban, Toru Murayama, Kazuhiko Okita, Shunta Tohtake, Loi Tonthat, Yohei Ozawa, Seji Asamitsu, Hiroshi Okamoto, Takashi Kamei, Takaaki Abe

    AIP Advances　16　(2)　025319-1-025319-5　2026/02/01

    DOI： 10.1063/9.0001065 　

    More details Close

    We have developed a low-cost, rapid, and highly sensitive antigen test for Fusobacterium Nucleatum that utilizes the antigen-antibody reaction between magnetic nanoparticles and biological materials (antigens), which changes the magnetic flux passing through the small pickup coil. The magnetic flux of the pickup coil decreased with increasing antigen concentration because the density of magnetic nanoparticles decreased with increasing antigen concentration. The driving coil was air-cooled to reduce thermal drift, and the size of the differential pickup coil was reduced to achieve a high signal-to-noise ratio in magnetic flux measurements. After the antigen-antibody reaction, the magnetic nanoparticles and antigens are agglutinated by magnetic force, reducing the influence of contaminants and allowing the concentration of Fusobacterium Nucleatum to be evaluated without a washing step. The method was validated using samples collected from 28 individuals. The results showed a strong correlation with qPCR analysis (correlation coefficient = 0.69, p < 0.0001), highlighting the accuracy and precision comparable to conventional qPCR systems. The proposed approach offers several advantages for bacterial detection: low cost, rapid evaluation, high sensitivity, and minimal interference from contaminants.

  2. Magnetic hyperthermia using iron oxide nanoparticles via LDDS suppressed lymph node and lung metastasis in a mouse model Peer-reviewed

    Akihiro Kuwahata, Ariunbuyan Sukhbaatar, Akihiro Shikano, Loi Tonthat, Takayuki Kagami, Riku Shinohara, Shiro Mori, Shin Yabukami, Tetsuya Kodama

    Scientific Reports　15　(1)　1-16　2025/11/25

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-025-25808-5 　

    eISSN： 2045-2322

    More details Close

    Lymph node (LN) metastasis remains a critical determinant of cancer progression and prognosis, yet surgical interventions result in adverse effects. In this preclinical study, we investigated a minimally invasive therapeutic approach combining magnetic hyperthermia (MH) with a lymphatic drug delivery system (LDDS) using iron oxide nanoparticles (Resovist®). A custom-built MH device precisely regulated LN temperature at 45 °C. Using a mouse model (MXH10/Mo/lpr) of tumor-suspicious LN (ts-LN) metastasis, Resovist® was intranodally administered, followed by MH treatment. This combination significantly suppressed tumor growth in ts-LN and reduced lung metastasis, with enhanced M1 macrophage polarization and antitumor immune responses. Histopathology confirmed tumor necrosis and localized nanoparticle deposition, while qPCR of spleen tissue indicated differential immune modulation. No overt systemic toxicity was observed. The results demonstrated that this theranostic approach allows for real-time thermal control and effective regional tumor inhibition. The technique holds promise for early-stage cancer patients, offering a non-invasive, image-guided alternative to surgical LN resection with the potential for clinical translation.

  3. Magnetic properties of antigen-antibody reaction aggregates of magnetic nanoparticles and proteins and protein detection Peer-reviewed

    Shin YABUKAMI, Mitsuki KITAKAZE, Toru MURAYAMA, Loi TONTHAT, Yohei OZAWA, Hiroshi OKAMOTO, Takashi KAMEI, Miyuki TANAKA, Yoshikazu TANAKA, Takaaki ABE

    Journal of the Japan Society of Applied Electromagnetics and Mechanics　33　(4)　364-369　2025/10

    Publisher: Japan Society of Applied Electromagnetics and Mechanics

    DOI： 10.14243/jsaem.33.364 　

    ISSN： 0919-4452

    eISSN： 2187-9257

    More details Close

    We aim to apply protein sensors to rapid intraoperative diagnosis of lymph node metastasis. In the present study, cytokeratin, which is a biomarker of lymph node metastasis, was bound to protein G-coated magnetic nanoparticles (FG beads, 180 nmφ) via primary antibody (Anti-Cytokeratin AE1/AE3 Antibody (Monoclonal Mouse IgG1)). The increase of the protein aggregated the magnetic nanoparticles and enhanced the magnetic signal. We have observed magnetic nanoparticles and protein aggregates by cryo-electron microscopy to obtain evidence for this hypothesis. By adding gold nanoparticles to the antibody, we observed the cross-bridging of magnetic nanoparticles via the antigen. Lymph nodes were obtained from two esophageal cancer patients and one non-cancer patient (corrosive esophagitis). Lymph nodes from cancer patients contain cytokeratin, which promotes the aggregation of magnetic nanoparticles and increases the magnetic signal. Statistically significant differences could be assessed between two cancer and non-cancer patients, suggesting the potential of intraoperative rapid diagnosis.

  4. High‐Frequency Thin‐Film Magnetic Sensor for Precise Magnetic Near‐Field Measurement Invited Peer-reviewed

    Loi Tonthat, Ryota Suzuki, Jerdvisanop Chakarothai, Katsumi Fujii, Shin Yabukami

    IEEJ Transactions on Electrical and Electronic Engineering　20　(11)　1672-1678　2025/09/13

    Publisher: Wiley

    DOI： 10.1002/tee.70152 　

    ISSN： 1931-4973

    eISSN： 1931-4981

    More details Close

    Highly sensitive magnetic field sensors are essential for applications such as biomedical diagnostics and electromagnetic compatibility (EMC) assessments. This study focuses on optimizing a GHz‐range thin‐film magnetic sensor by incorporating a slit pattern in the magnetic layer, which improves impedance matching and current distribution. Amorphous CoNbZr thin‐film sensors with slit widths ranging from 0 μm (no slit) to 50 μm were fabricated. Among these, the 10 μm slit design exhibited the best impedance matching and magnetic field sensitivity. Additionally, a carrier suppression circuit was implemented to reduce phase noise, resulting in improved sensitivity, achieving a minimum detectable field of 1.41 × 10−11 T/√Hz. The sensor was employed for precise near‐field measurements in wireless power transfer (WPT) systems, where it outperformed conventional loop antennas. Experimental results demonstrated superior sensitivity and enhanced spatial resolution, particularly near the ferromagnetic resonance under specific DC bias and carrier frequency conditions. These findings highlight the potential of the optimized sensor for improving electromagnetic interference (EMI) and EMC assessments. © 2025 The Author(s). IEEJ Transactions on Electrical and Electronic Engineering published by Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

  5. Evaluation of Cytokeratin in Lymph Node Metastasis Using Magnetic Nanoparticles and Protein Aggregates Peer-reviewed

    Shin Yabukami, Toru Murayama, Koki Kaneko, Amane Ban, Loi Ton That, Yohei Ozawa, Hiroshi Okamoto, Takashi Kamei, Miyuki Tanaka, Yoshikazu Tanaka, Takaaki Abe

    IEEE Transactions on Magnetics　61　(9)　1-4　2025/09

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2025.3550893 　

    ISSN： 0018-9464

    eISSN： 1941-0069

    More details Close

    Abstract: We aim to apply protein sensors to rapid intraoperative diagnosis of lymph node metastasis. In the present study, cytokeratin, which is a biomarker of lymph node metastasis, was bound to protein G-coated magnetic nanoparticles (FG beads, 180 nm ϕ ) via primary antibody [Anti-Cytokeratin AE1/AE3 Antibody (Monoclonal Mouse IgG1)]. The increase of the protein aggregated the magnetic nanoparticles and enhanced the magnetic signal. We have observed magnetic nanoparticles and protein aggregates by cryo-electron microscopy to obtain evidence for this hypothesis. By adding gold nanoparticles to the antibody, we observed the crossbridging of magnetic nanoparticles via the antigen. Lymph nodes were obtained from two esophageal cancer patients and one noncancer patient (corrosive esophagitis). Lymph nodes from cancer patients contain cytokeratin, which promotes the aggregation of magnetic nanoparticles and increases the magnetic signal. Statistically significant differences could be assessed between two cancer and noncancer patients, suggesting the potential of intraoperative rapid diagnosis.

  6. Detection of GDF15 Protein using Ultra-Broadband Ferromagnetic Resonance of Magnetic Nanoparticles International-journal Peer-reviewed

    Shin Yabukami, Ryoya Masui, Toru Murayama, Junichi Honda, Loi Tonthat, Kazuhiko Okita, Akihiro Kuwahata, Takaaki Abe

    IEEE Magnetics Letters　1-5　2025/07/26

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/lmag.2025.3592474 　

    ISSN： 1949-307X

    eISSN： 1949-3088

  7. Evaluation of Aggregation Effect of Magnetic Nanoparticles by Antigen-antibody Reaction with Proteins Peer-reviewed

    K. Kaneko, T. Murayama, L. Tonthat, K. Okita, A. Ban, M. Tanaka, Y. Tanaka, S. Yabukami

    Transaction of the Magnetics Society of Japan Special Issues　9　(1)　92-96　2025/05/01

    DOI： 10.20819/msjtmsj.25TR912 　

    More details Close

    We developed a rapid, low-cost protein detection method using magnetic nanoparticles and demonstrated that GDF-15 (Growth Differentiation Factor 15) binding induces nanoparticle aggregation through an antigen-antibody reaction. This aggregation by cross-bridging increased magnetic responsiveness to switch magnetic fields with increasing GDF-15 concentration, although this aggregation was not quantitatively verified. In this study, transmission electron microscopy (TEM) was used to quantitatively assess the role of GDF-15 in promoting the aggregation of magnetic nanoparticles. TEM analysis showed that the GDF-15-bound samples formed approximately 1.5% more aggregates larger than 0.03 μm² compared to controls, confirming the cross-bridge effect was confirmed.

  8. Magnetic Hyperthermia for Cancer Treatment Invited

    K. Mitobe, L. Tonthat, A. Kuwahata

    Magnetics Society of Japan　20　(2)　1-6　2025/04/01

  9. Magnetic heating properties of hollow Fe3O4 nanoparticles with magnetic vortex structure Peer-reviewed

    H. Akiyama, L. Tonthat, A. Kuwahata, S. Yabukami, S. Kobayashi

    Transaction of the Magnetics Society of Japan Special Issues　8　(2)　79-83　2024/09/01

    DOI： 10.20819/msjtmsj.24TR816 　

    ISSN： 2432-0471

    More details Close

    Hollow-structured Fe3O4 nanoparticles, with an increased surface area compared to solid counterparts, show promise in cancer therapy through potential applications in magnetic hyperthermia and drug delivery via encapsulation. This study investigates the shell thickness-dependent heating efficiency of hollow Fe3O4 nanoparticles with a magnetic vortex structure less prone to magnetization reversal. Using the solvothermal method, we maintained a nearly constant inner diameter (230 nm) while varying shell thickness (400 nm, 530 nm, and 720 nm in outer diameter denoted as H400, H530, and H720) by adjusting only the outer diameter through a change in reagent ratio and heating temperature. Under an applied AC magnetic field of 270 kHz, 429.5 Oe, the specific absorption rate (SAR) values of H400, H530, and H720 samples (calculated based on the initial temperature rising rate observed during the time interval of 0 to 30s) were 265.1, 130.2, and 120.9 W/g, respectively. These findings, supported by DC hysteresis loss experiments and micromagnetic simulations of AC hysteresis loss, indicate that particles with thinner shells at the same inner diameter exhibit enhanced heating efficiency due to a stable magnetic vortex structure and significant hysteresis loss. This highlights the potential utility of hollow nanoparticles with thin shells as a particle shape for magnetic hyperthermia.

  10. Enhanced Magneto-Optical Properties of Au–Fe₃O₄ Heterodimer Nanoparticles Synthesized With Triiron Dodecacarbonyl International-journal Peer-reviewed

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    IEEE Transactions on Magnetics　60　(9)　1-5　2024/09

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2024.3415086 　

    ISSN： 0018-9464

    eISSN： 1941-0069

    More details Close

    Abstract: This study presents a pioneering and efficient method for synthesizing Au–Fe3O4 heterodimer nanoparticles (NPs) with enhanced magneto-optical properties via a thermal decomposition route. By utilizing triiron dodecacarbonyl (Fe3(CO)12) as a safer alternative to the commonly used toxic iron pentacarbonyl (Fe(CO)5), a near 100% production yield was achieved through optimization of the molar ratio of Au seeds to Fe3(CO)12 (0.6:2.0 m mol) and reflux time (60 min). The resulting heterodimer NPs exhibited a medium diameter of d0=6.89 nm for the Au component and d0=14.51 nm for the Fe3O4 component, with the Au seeds having a diameter of d0=4.22 nm. These NPs displayed remarkable magneto-optical properties, including high magnetization (Ms = 72.6 emu/g-Fe3O4 at 300K) and a distinct plasmon resonance band at 553 nm. This band experienced a 42 nm red shift compared to pure Au NPs, attributed to electron transfer at the interface between Au and Fe3O4. The lattice match between the materials suggests epitaxial growth of Fe3O4 onto the Au surface, enhancing the stability of heterodimer NPs. The use of triiron dodecacarbonyl as a precursor in the synthesis of these high-quality Au–Fe3O4 NPs highlights their significant potential for magnetic-plasmonic bio-applications.

  11. An Ultra-Broadband Magnetic Susceptivity Evaluation of Magnetic Nanoparticle and Protein

    Shin Yabukami, Junichi Honda, Toru Murayama, Loi Tonthat, Kazuhiko Okita

    2024 IEEE International Magnetic Conference - Short papers (INTERMAG Short papers)　1-2　2024/07/05

    Publisher: IEEE

    DOI： 10.1109/intermagshortpapers61879.2024.10576805 　

    More details Close

    Abstract: A new broad bandwidth detection of the GDF15 protein (Growth Differentiation Factor-15), which utilizes the broad bandwidth observation up to 67 GHz, has been proposed. We prepared the sandwich-type bound method using a primary and secondary antibody with additional magnetic nanoparticles on an Au film. A DC field application enhanced sharp ferromagnetic resonance, which improved the signal-to-noise ratio of detecting GDF15. The density of GDF15 changed as follows: 0, 0.5, 5, and 50 μg/ml . The magnetic susceptivity and FMR intensity increased clearly with the increase of the GDF15 density.

  12. Efficient Synthesis and Magneto-Optical Enhancement of Au-Fe3O4 Hetero-dimer Nanoparticles with Triiron Dodecacarbonyl

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    2024 IEEE International Magnetic Conference - Short papers (INTERMAG Short papers)　1-2　2024/07/05

    Publisher: IEEE

    DOI： 10.1109/intermagshortpapers61879.2024.10576807 　

    More details Close

    Abstract: This study presents a pioneering and efficient method for synthesizing Au-Fe 3 O 4 hetero-dimer nanoparticles (NPs) with enhanced magneto-optical properties via a thermal decomposition route. Employing triiron dodecacarbonyl (Fe 3 (CO) 12 ) as a safer alternative to the commonly used toxic iron pentacarbonyl (Fe(CO) 5 ), we achieved a near 100% production yield by optimizing the molar ratio of Au seeds to Fe 3 (CO) 12 (0.6:2.0 mmol) and reflux time (60 min). The resulting hetero-dimer NPs, featuring an Au component of medium diameter d0=6.89 nm and a Fe 3 O 4 component of d0=14.51 nm (with d0=4.22 nm Au seeds used), exhibited remarkable magneto-optical properties. These included a high magnetization ( Ms=72.6 emu/g−Fe3O4 at 300K) and a well-defined plasmon resonance band at 553 nm, showcasing a 42 nm red shift from that observed in pure Au NPs. The use of triiron dodecacarbonyl as a precursor in the synthesis of these high-quality Au-Fe 3 O 4 NPs highlights their significant potential for magnetic-plasmonic bio-applications.

  13. Thin Film Magnetic Sensor for Magnetic Near‐Field Measurement in Wireless Power Transfer System Peer-reviewed

    Loi Tonthat, Jerdvisanop Chakarothai, Ryota Suzuki, Katsumi Fuji, Shin Yabukami

    IEEJ Transactions on Electrical and Electronic Engineering　19　(11)　1-7　2024/06/11

    DOI： 10.1002/tee.24148 　

    ISSN： 1931-4973 1931-4981

    More details Close

    Abstract In this study, we employed a high-frequency-driven thin-film magnetic sensor to precisely measure the magnetic near field with enhanced spatial resolution, a challenge often faced by conventional loop antennas. Our study introduced an innovative approach utilizing this magnetic sensor to assess the magnetic near field in wireless power transfer systems, comparing its performance against that of a loop antenna. Our findings demonstrate that the magnetic sensor achieves its peak signal-to-noise ratio at a DC bias field of 4.7 Oe and carrier frequency of 0.5 GHz, boasting a detection limit for magnetic fields of ~0.4 A/m. Moreover, the magnetic field trend measured by the magnetic sensor closely aligns with simulation results, exhibiting sharper changes around the center compared to the loop antenna. These results highlight the superior sensitivity and spatial resolution of the magnetic sensor over conventional loop antennas. By enhancing the reliability of electronic systems across diverse applications, these sensors pave the way for advanced EMI/EMC evaluation techniques. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

  14. Magnetic response of aggregation mixed with magnetic nanoparticles and protein for simultaneous protein detection Peer-reviewed

    Yabukami, Shin, Toru Murayama, Koki Kaneko, Junichi Honda, Loi Tonthat, Kazuhiko Okita

    AIP Advances　14　(3)　035102-1-035102-6　2024/03/01

    DOI： 10.1063/9.0000836 　

  15. Ferromagnetic resonance-based heat dissipation in dumbbell-like Au-Fe3O4 nanoparticles International-journal Peer-reviewed

    Loi Tonthat, Akihiro Kuwahata, Shin Yabukami

    AIP Advances　14　(1)　015343-1-015343-6　2024/01/26

    DOI： 10.1063/9.0000825 　

  16. Dumbbell-like Au–Fe₃O₄ nanoparticles for magnetic hyperthermia Peer-reviewed

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    AIP Advances　14　(1)　015035-1-015035-5　2024/01/19

    Publisher: AIP Publishing

    DOI： 10.1063/9.0000821 　

    eISSN： 2158-3226

    More details Close

    Dumbbell-shaped hybrid nanoparticles, consisting of gold and iron oxide (Au-Fe3O4 NPs), show promise for magnetic hyperthermia cancer therapy. However, conventional synthesis methods using toxic iron pentacarbonyl (Fe(CO)5) raise safety concerns. We propose a safer approach using triiron dodecacarbonyl (Fe3(CO)12) as a precursor. We synthesize these NPs by initially reducing gold (III) chloride trihydrate with a tert-butylamine-borane complex at room temperature, yielding Au NPs. These Au NPs are combined with a Fe3(CO)12 solution and heated to 300 °C for 1 hour, resulting in the desired dumbbell-shaped Au-Fe3O4 NPs. Characterization confirms their morphology, with average sizes of 5 nm for Au NPs and 15 nm for Fe3O4 NPs. Our systematic evaluation of hydrophilic-treated Au-Fe3O4 NPs (Ms=49.5 emu/g at 3T, 300K) demonstrates temperature increases beyond the therapeutic threshold of 45 °C (ΔT=8 °C) at higher field strengths (8.6–30.0 kA/m), highlighting their cancer treatment potential. Quantitative analysis reveals superb performance, with a specific absorption rate (SAR) of 60.0 W/g and intrinsic loss power (ILP) of 0.25 nHm2kg−1 at the maximum field strength. These findings emphasize the significant potential of our dumbbell-shaped Au–Fe3O4 NPs for magnetic hyperthermia.

  17. Ultrafast Heating Rate of Ultrasmall Gold-Coated Iron Oxide Magnetic Nanoparticles by Ferromagnetic Resonance Peer-reviewed

    Loi Tonthat, Akihiro Kuwahata, Tomoyuki Ogawa, Shin Yabukami

    IEEE Transactions on Magnetics　59　(11)　1-5　2023/11

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2023.3287550 　

    ISSN： 0018-9464

    eISSN： 1941-0069

    More details Close

    Abstract: In this study, we demonstrated experimental findings on the ultrafast heating capabilities of ultrasmall gold-coated iron oxide magnetic nanoparticles (MNPs) (Fe3O4 @ Au NPs) utilizing the ferromagnetic resonance (FMR) effect. A lab-made setup was employed to evaluate the FMR and temperature increment of NPs under FMR conditions. The resonant frequency of both Fe3O4 @ Au NPs and their uncoated Fe3O4 NPs was several GHz and increased with the strength of the applied dc field as accurately described by the Kittel equation. At a given dc field, the resonant frequency of Fe3O4 @ Au NPs slightly shifted lower than compared to Fe3O4 NPs. Remarkably, the initial temperature rising rate reached maximum values corresponding to the dc fields for FMR condition (e.g., 1.294 °/s and 3.894 °C/s under HDC=1200 Oe for RF field of fAC=4 GHz and HAC=4 Oe for Fe3O4 @ Au and Fe3O4 NPs, respectively). These values were two orders of magnitude higher than that of Néel-Brownian relaxation for conventional magnetic hyperthermia (MH). Furthermore, the maximum value of the heating rate increased with higher RF field frequencies. These results demonstrate the potential of controlling the temperature of NPs by adjusting RF field and dc field parameters, offering promising prospects for therapeutic temperature control in MH applications.

  18. Ultrasmall Fe₃O₄@Au Composite Nanoparticles With Different Sizes of Fe₃O₄ for Magnetic Hyperthermia International-journal Peer-reviewed

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    IEEE Transactions on Magnetics　59　(11)　1-5　2023/11

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2023.3287505 　

    ISSN： 0018-9464

    eISSN： 1941-0069

    More details Close

    Abstract: We present the synthesis and characterization of ultrasmall iron oxide/gold composite nanoparticles (Fe3O4@Au NPs) with different Fe3O4 sizes, along with an evaluation of their heating efficiency for potential use in magnetic hyperthermia (MH) applications. The Fe3O4 NPs of approximately 5, 10, and 13 nm were synthesized using the thermal decomposition method, followed by gold deposition via the reduction of gold acetate at 190 °C. The morphology, structure, and magnetic properties of as-prepared Fe3O4 and their Fe3O4@Au NPs were determined and characterized by transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM) analyses. The magnetization of Fe3O4 NPs increased with increasing their size, reaching 74.7 emu/g for ~13 nm NPs. The Fe3O4@Au NPs contained 94.3%, 96.3%, and 77.0% Au (wt%) for Fe3O4~5, Fe3O4~10, and Fe3O4~13 nm@Au, respectively, estimated from the magnetization values. The heating efficiency specific absorption rate (SAR) demonstrated an increasing trend with Fe3O4 size, reaching maximum values of 136.7 and 23.4 W/g under a magnetic field of 25.7 kA/m and 267 kHz for Fe3O4~13 nm and Fe3O4~13 nm@Au NPs, respectively. These results indicate high heating efficient capabilities and the potential use of NPs for MH applications.

  19. Magnetic Susceptibility-Based Detection of Fusobacterium nucleatum in Human Saliva Peer-reviewed

    Kazuhiko Okita, Pu Youcheng, Loi Tonthat, Toru Murayama, Shin Yabukami, Yohei Ozawa, Seji Asamitsu, Hiroshi Okamoto, Takashi Kamei

    IEEE Magnetics Letters　14　1-5　2023/08/23

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/LMAG.2023.3308062 　

    ISSN： 1949-307X

    eISSN： 1949-3088

    More details Close

    This letter presents an innovative method for rapid and precise measurement of bacteria in liquid samples for point-of-care testing. The method utilizes the bacteria concentration-dependent ac susceptibility of magnetic nanoparticles, allowing for efficient and practical bacterial detection. The ac susceptibility of the magnetic nanoparticles/bacteria aggregate exhibits a decrease proportional to the bacteria concentration, attributed to the influence of bacteria on the magnetic coupling between the magnetic nanoparticles and magnetic dynamic response of the aggregate. To validate the performance of our method, we conducted measurements on Fusobacterium nucleatum samples obtained from both healthy individuals and cancer patients. The results demonstrated a robust correlation (correlation factor up to 0.94) between our measurements and the results obtained through quantitative polymerase chain reaction (qPCR) analysis, highlighting the high precision and accuracy of our method in quantifying bacteria, which is comparable to a qPCR system. The simplified apparatus not only reduces costs but also saves time by eliminating the need for DNA amplification of short segments, making it a promising alternative for rapid and precise bacterial measurement in point-of-care testing.

  20. Highly Sensitive Bio-Detection Utilizing Magnetic Phase Transition by Aggregates of Magnetic Nanoparticles and Biomolecules Invited

    Loi Tonthat, Shin Yabukami

    The Journal of The Institute of Electrical Engineers of Japan　143　(8)　496-499　2023/08/01

    Publisher:

    DOI： 10.1541/ieejjournal.143.496 　

    ISSN： 1340-5551 1881-4190

  21. Improvement of near-infrared photoelectric conversion efficiency of solution-coated (C8BTBT)(F4TCNQ) films by adding Fe₃O₄ nanoparticles Peer-reviewed

    Naomi Uchiyama, Yosei Shibata, Loi Tonthat, Yuji Matsuura

    Japanese Journal of Applied Physics　62　(5)　056501-1-056501-6　2023/05/18

    Publisher: IOP Publishing

    DOI： 10.35848/1347-4065/acceec 　

    ISSN： 0021-4922

    eISSN： 1347-4065

    More details Close

    Abstract To realize transparent photoelectric conversion elements useful for optical wireless power-transmission systems and sensors, we investigated thin films of 2,7-dioctyl[1]benzothieno [3,2-b][1]benzothiophene and fluorinated derivatives of 7,7,8,8,-tetracyanoquinodimethane (C8BTBT)(F4TCNQ) produced by a simple solution-coating method. We found that the addition of Fe3O4 nanoparticles (NPs) to a (C8BTBT)(F4TCNQ) solution promoted crystal formation and increased the optical absorption of the film. This was because the addition of NPs formed a middle layer, and the NPs acted as starting points for the formation of crystal nuclei. Photocurrent measurements confirmed that the quantum efficiency (QE) of the film with NPs was improved by about 14-fold compared with the film without NPs. The promotion of crystal formation increased optical absorption and significantly improved QE.

  22. Ultrasmall Fe3O4@Au Composite Nanoparticles with Different Sizes of Fe3O4 for Magnetic Hyperthermia (digest)

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    2023 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers)　1-2　2023/05

    Publisher: IEEE

    DOI： 10.1109/intermagshortpapers58606.2023.10228777 　

  23. Ultrafast Heating Rate of Ultrasmall Gold-coated Iron Oxide Magnetic Nanoparticles by Ferromagnetic Resonance (digest)

    Loi Tonthat, Akihiro Kuwahata, Tomoyuki Ogawa, Shin Yabukami

    2023 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers)　1-2　2023/05

    Publisher: IEEE

    DOI： 10.1109/intermagshortpapers58606.2023.10228356 　

  24. Method for Rapid Detection of Bacteria Using Magnetic Nanoparticle Aggregates Peer-reviewed

    Y. Pu, H. Zhao, T. Murayama, L. Tonthat, K. Okita, Y. Watanabe, S. Yabukami

    Journal of the Magnetics Society of Japan　47　(3)　66-69　2023/05/01

    Publisher: The Magnetics Society of Japan

    DOI： 10.3379/msjmag.2305r003 　

    ISSN： 1882-2924

    eISSN： 1882-2932

    More details Close

    A novel method for the rapid detection of bacteria in the liquid phase for point-of-care testing was developed using magnetic nanoparticles (MNPs) conjugated with antibodies. We utilized the magnetic characteristic that the magnetic susceptibility decreases when the magnetism of MNP aggregate changes from ferromagnetism to superparamagnetism after bacteria bind to MNPs through an antigen-antibody reaction (Nanomag-D, 500 nmφ, 0.2 μl/sample). The magnetic susceptibility of Fusobacterium nucleatum samples was measured using a lab-made detection setup. We found that the susceptibility depends on the concentration of Fusobacterium nucleatum with optical density (OD) values ranging from 10-4 to 1 (i.e. 8 × 104 ~ 8 × 108 CFU/ml). In addition, the detection time was only about 49 seconds, which shows promise for point-of-care testing.

  25. Research Group Introduction: Tohoku University Graduate School of Engineering, Yabukami-Kuwahata Laboratory Invited

    Loi Tonthat, Kuwahata Akihiro, Yabukami Shin

    IEEJ Transactions on Fundamentals and Materials　143　(4)　NL4_4　2023/04/01

    Publisher: Institute of Electrical Engineers of Japan (IEE Japan)

    DOI： 10.1541/ieejfms.143.nl4_4 　

    ISSN： 0385-4205

    eISSN： 1347-5533

  26. Method for measuring magnetic susceptibility of magnetic nanoparticles up to millimeter-wave frequency range Peer-reviewed

    Youcheng Pu, Loi Tonthat, Toru Murayama, Kazuhiko Okita, Shin Yabukami

    AIP Advances　13　(2)　025129-1-025129-6　2023/02/01

    DOI： 10.1063/9.0000589 　

  27. Development of gold-coated magnetic nanoparticles as a theranostic agent for magnetic hyperthermia and CT imaging applications Peer-reviewed

    Loi Tonthat, Mone Kimura, Tomoyuki Ogawa, Narufumi Kitamura, Yoshio Kobayashi, Kohsuke Gonda, Shin Yabukami

    AIP Advances　13　(2)　025239-1-025239-5　2023/02

    Publisher: AIP Publishing

    DOI： 10.1063/9.0000592 　

    eISSN： 2158-3226

    More details Close

    In this study, we aim to develop gold-coated Fe3O4 nanoparticles (Fe3O4@Au NPs) as theranostic agents for magnetic hyperthermia and CT imaging applications. The Fe3O4 NPs were synthesized via thermal decomposition method, and the gold was then deposited onto the surface of Fe3O4 NPs by reducing gold acetate at 190 °C. The average sizes of Fe3O4 and Fe3O4@Au NPs were 5.2 nm and 6.1 nm, respectively, which are effectively removed by the kidneys. The magnetization of Fe3O4@Au NPs (9.7 emu/g-Fe3O4) at 300 K was much smaller than that of Fe3O4 NPs (52.4 emu/g-Fe3O4). The heating efficiency of Fe3O4@Au NPs in water was sufficient to treat the tumor at 43–45 °C, and their high CT value of 851 HU was obtained. The synthesized ultrasmall Fe3O4@Au NPs showed great promise as a potential theranostic agent for magnetic hyperthermia and CT imaging applications.

  28. A simple antigen-antibody reaction using ultrasmall FeCo nanoparticles Peer-reviewed

    Loi Tonthat, Toru Murayama, Nobukiyo Kobayashi, Shin Yabukami, Wakako Ikeda-Ohtsubo, Ken Ichi Arai

    AIP Advances　13　(2)　025009-1-025009-4　2023/02

    Publisher: AIP Publishing

    DOI： 10.1063/9.0000569 　

    eISSN： 2158-3226

    More details Close

    In this study, we prepared ultrasmall FeCo nanoparticles (NPs) with a high magnetic moment and examined their antigen-antibody reaction for biodetection applications. The FeCo NPs were collected from the FeCo-BaF2 nanogranular film with Fe:Co:Ba:F = 14:11:21:54 at.%, by dissolving the film in water since the BaF2 matrix was deliquescent. The size of FeCo NPs was ∼5 nm and the saturation magnetization was estimated to be ∼15.30 kG (149.0 emu/g). The Candida albicans antibodies (abcam ab53891)-conjugated FeCo NPs were collected by using an ultracentrifugal separation (110 000 rpm, 90 min), they were then reacted with Candida albicans. The obtained result indicates that Candida albicans were absorbed successfully onto FeCo NPs, and the number of Candida albicans bound to FeCo NPs counted from the micrographs of the aggregates of FeCo NPs and Candida albicans increased significantly by adding sonication treatment of the film in water before binding them to the antibodies. The success of antigen-antibody reaction of ultrasmall NPs with high magnetic moment improves detection sensitivity as well as offers potential detection for smaller biomolecules.

  29. Resonance frequency above 20 GHz in superparamagnetic NiZn-Ferrite Peer-reviewed

    Sarath Arackal, Kouhei Nozawa, Ralandinliu Kahmei, Ton That Loi, Shin Yabukami, S A Shivashankar, Masahiro Yamaguchi, Navakanta Bhat, Ranajit Sai

    Applied Physics Letters　121　(6)　1-6　2022/08/09

    Publisher: AIP Publishing

    DOI： 10.1063/5.0102965 　

    ISSN： 0003-6951

    eISSN： 1077-3118

    More details Close

    ABSTRACT We investigate the frequency dispersion of complex permeability in the GHz range in superparamagnetic nickel–zinc ferrite thin films with different Ni/Zn ratios using a microstrip probe. The films, comprising crystallites as small as 3 nm and deposited by a microwave-irradiation-assisted solvothermal method, exhibit the coexistence of two resonance characteristics—a ferromagnetic resonance peak (𝑓𝑟 ) at ∼2 GHz and a superparamagnetic resonance peak (𝑓𝑏) above 20 GHz, breaching Snoek's limit. The high value of 𝑓𝑟 is attributed to the high surface anisotropy and far-from-equilibrium distribution of cations in the lattice, while 𝑓𝑏 is attributed to the thermally driven superparamagnetic relaxation of ferrite nanocrystallites in the thin films. This work demonstrates the feasibility of employing superparamagnetic ferrite thin films so deposited as excellent CMOS-integrable magnetic components for high-speed and high-frequency electromagnetic device applications.

  30. Simplified Fabrication of Magnetic Nanoparticles With Directly Adsorbed Antibodies for Bacteria Detection Peer-reviewed

    Yoneyama Tsuyoshi, Kuwahata Akihiro, Murayama Toru, Loi Tonthat, Yabukami Shin, Sato Yuya, Teramura Yuji, Ikeda-Ohtsubo Wakako, Ogawa Tomoyuki

    IEEE Transactions on Magnetics　58　(8)　1-6　2022/08

    DOI： 10.1109/TMAG.2022.3168360 　

    ISSN： 0018-9464

    eISSN： 1941-0069

  31. Animal Experiment with PID-based Automatic Temperature Control System for Magnetic Hyperthermia Peer-reviewed

    A. Shikano, L. Tonthat, A. Kuwahata, A. Sukhbaatar, T. Kodama, S. Yabukami

    Transaction of the Magnetics Society of Japan Special Issues　6　(1)　100-104　2022/05/01

    DOI： 10.20819/MSJTMSJ.22TR519 　

    ISSN： 2432-0471

  32. A Simple and High-Accuracy PID-Based Temperature Control System for Magnetic Hyperthermia Using Fiber Optic Thermometer Peer-reviewed

    Akihiro Shikano, Loi Tonthat, Shin Yabukami

    IEEJ Transactions on Electrical and Electronic Engineering　16　(5)　807-809　2021/05

    DOI： 10.1002/tee.23361 　

    ISSN： 1931-4973 1931-4981

    eISSN： 1931-4981

  33. Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment Peer-reviewed

    Loi Tonthat, Fumitaka Aki, Kazutaka Mitobe, Shin Yabukami, Yoshiyuki Yamamoto

    11th Asian-Pacific Conference on Medical and Biological Engineering. APCMBE 2020. IFMBE Proceedings, vol 82. Springer, Cham. (book-chapter, 41 peer-reviewed papers)　82　272-277　2021/03/19

    Publisher: Springer International Publishing

    DOI： 10.1007/978-3-030-66169-4_33 　

    ISSN： 1680-0737

    eISSN： 1433-9277

  34. Impact of Complex Permeability Measurements Up to Millimeter-Wave Frequency Range Peer-reviewed

    S. Yabukami, K. Nozawa, L. Tonthat, K. Okita, R. Sai

    IEEE Transactions on Magnetics　57　(2)　6100405-5　2021/02

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2020.3011971 　

    ISSN： 0018-9464

    eISSN： 1941-0069

  35. Development of an Automatic Localization System of Magnetic Particles for Hyperthermia Therapy Peer-reviewed

    Loi Tonthat, Kazutaka Mitobe, Shin Yabukami

    IEEE Transactions on Magnetics　57　(2)　5300205-5　2021/02

    Publisher: Institute of Electrical and Electronics Engineers (IEEE)

    DOI： 10.1109/tmag.2020.3008490 　

    ISSN： 0018-9464

    eISSN： 1941-0069

  36. Development of heating element and techniques for detecting its temperature and position for hyperthermia

    Loi Tonthat, Mitobe Kazutaka, Yabukami Shin

    日本磁気学会学術講演概要集（2020）　86-86　2020/12

  37. Effect of applied magnetic field on permeability and heating efficiency of multifunctional micro/nano-magnetic particles for hyperthermia therapy Peer-reviewed

    Loi Tonthat, Yoshiyuki Yamamoto, Kazutaka Mitobe, Shin Yabukami

    AIP Advances　10　(12)　125324-125324　2020/12/01

    Publisher: AIP Publishing

    DOI： 10.1063/9.0000123 　

    eISSN： 2158-3226

  38. Coplanar line type thin film magnetic field sensor with flip chip bonding Peer-reviewed

    H. Kudo, H. Uetake, H. Onodera, L. Tonthat, K. Okita, S. Yabukami, J. Hayasaka

    Transaction of the Magnetics Society of Japan (Special Issues)　4　(1)　32-36　2020/05/01

    DOI： 10.20819/msjtmsj.20TR417 　

    ISSN： 2432-0471

    More details Close

    A very sensitive thin-film sensor was developed by using a straight coplanar line-type sensor with flip chip bonding. SrTiO film (about 3-μm thick), amorphous Co85Nb12Zr3 film and Cu/Cr film (2 μm/0.2 μm) were fabricated. We discuss the high-frequency characteristics and sensitivity of the sensor element through comparison of cases with and without flip chip bonding. Good sensitivity with a phase change of over 290 degrees/Oe was obtained with flip chip bonding.

  39. Measurement of bacteria using magnetic beads by switching magnetic field Peer-reviewed

    高橋 隼之介, Ton That Loi, 小野寺 英彦, 沖田 和彦, 藪上 信, 横田 琴音, 古谷 真衣子, 金高 弘恭, 三浦 由則, 髙橋 英樹, 渡部 芳彦, 秋山 利津子

    The papers of technical meeting on magnetics, IEE Japan　2019　(220)　63-66　2019/12/26

  40. High frequency permeability measurement of magnetic thin film by microstrip probe Peer-reviewed

    能澤 昂平, 沖田 和彦, Ton That Loi, 薮上 信, 遠藤 恭, 島田 寛, 斉藤 伸, 内海 良一

    The papers of technical meeting on magnetics, IEE Japan　2019　(133)　13-16　2019/12/05

    Publisher:

  41. A simple and rapid detection system for oral bacteria in liquid phase for point-of-care diagnostics using magnetic nanoparticles Peer-reviewed

    Loi Ton That, Shunnosuke Takahashi, Hidehiko Onodera, Kazuhiko Okita, Shin Yabukami, Kotone Yokota, Maiko Furuya, Hiroyasu Kanetaka, Yoshinori Miura, Hideki Takahashi, Yoshihiko Watanabe, Ritsuko Akiyama

    AIP Advances　9　(12)　125325-1-125325-4　2019/12

    DOI： 10.1063/1.5130437 　

    eISSN： 2158-3226

  42. Permeability Measurements of Thin Film Using a Flexible Microstrip Line-Type Probe Up To 67 GHz

    K. Nozawa, K. Okita, Loi Tonthat, S. Yabukami, Y. Endo, Y. Shimada, S. Saito, R. Utsumi

    Proceedings of The 43rd Annual Conference on MAGETICS in Japan　80-80　2019/11/25

  43. Measurement of bacteriausing magnetic beads by switching magnetic field

    S. Takahashi, Loi Tonthat, H. Onodera, K. Okita, S. Yabukami, K. Yokota, M. Furuya, H. Kanetaka, Y. Miura, H. Takahashi

    Proceedings of The 43rd Annual Conference on MAGETICS in Japan　100-100　2019/09/25

  44. Flip-chip bonded high-frequencythin-film magnetic field sensor

    H. Kudo, H. Uetake, H. Onodera, Loi Tonthat, S. Yabukami, J. Hayasaka, K. I. Arai

    Proceedings of The 43rd Annual Conference on MAGETICS in Japan　78-78　2019/09/25

  45. Evaluation of AC magnetization and heat dissipation of Au coated Fe2O3 particles

    Tsuyoshi Yamaminami, Shota Kobayashi, Loi Tonthat, Kazutaka Mitobe, Shin Yabukami, Tsutomu Yamada, Satoshi Ota, Yasushi Takemura

    Proceedings of The 43rd Annual Conference on MAGETICS in Japan　108-108　2019/09/25

  46. Magnetic field dependence of heating property of resovist® for magnetic hyperthermia Peer-reviewed

    Loi Tonthat, Yamamoto Yoshiyuki, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    IEEJ Transactions on Electrical and Electronic Engineering　14　(4)　648-649　2019/04

    DOI： 10.1002/tee.22848 　

    ISSN： 1931-4973

    eISSN： 1931-4981

  47. Study on Wireless Detection Techniques of Temperature and Position for Hyperthermia Using Magnetic Particles with Low Curie Temperature

    Loi Tonthat

    Akita University (Doctoral dissertation)　2019

    Publisher: Akita University

    DOI： 10.20569/00003803 　

    More details Close

    Cancer is the second leading cause of death globally behind ischemic heart disease and stroke, accounting for an estimated 9.6 million deaths in 2018 according to World Health Organization. Magnetic hyperthermia is a promising cancer therapy which has been gaining more attention in recent years owing to fewer side effects compared to chemotherapy and less invasive than surgical therapy. This therapy utilizes the fact that the antitumor effect occurs when the tumor is heated continuously within the therapeutic temperature range of 40‒45℃. Heat generation in magnetic hyperthermia mainly ascribes to hysteresis and/or relaxation loss from magnetic particles subjected to a high-frequency magnetic field.To date, magnetic hyperthermia applications capable of heating the affected part at a constant temperature while being minimally invasive in detecting the temperature and position of heating element are not established, thus the development of such systems are needed. So far, we are aiming to develop an induction heating system while monitoring the temperature and position of heating element. In previous studies, Mitobe et al. succeeded in developing a microsize thermosensitive ferromagnetic implant with low Curie temperature (FILCT) as a self-controlled heating element. FILCT was then coated with gold to improve its heating efficiency (Au Au-FILCT). Furthermore, a wireless temperature measurement method has been proposed to monitor the temperature of the tumor during treatment by using the implant as a thermal probe.The results obtained in this study are listed below.(1) Development of hyperthermia implant with high heating efficiency and high permeabilityThe previously developed Au-FILCT improved significantly the heating efficiency of FILCT (8 times), but part of the applied magnetic field was shielded ascribed to the conductive coating around FILCT. As a result, the change in the detected voltage induced in pickup coil (hereafter pickup voltage) was reduced by half, thereby the accuracy of our wireless thermometry was significantly lowered compared to that of FILCT. As an alternative approach to the gold coating, we proposed to mix FILCT with a high heating-efficient magnetic nanofluid. In the case of using a commercial nanofluid named Resovist® (MRI contrast agent), the heating efficiency of the proposed mixture of micro/nano-magnetic particles was improved 4.3 times, and the accuracy of the thermometry was improved 1.3 times compared to that of FILCT under a m agnetic field of 500 kHz, 4.95 kA/m. A similar tendency was obtained when using a lab-made nanofluid.(2) Development of localization technique of hyperthermia implantThe implant in the tumor cannot be seen from the body surface. When the implant deviates from the central axis of the magnetic field supply and detection unit composed of drive coil and pickup coil (MFSD unit), the magnetic flux density applied on the implant decreases, resulting in a decrease in its heating efficiency and the thermometry accuracy. To solve this problem, we devised a position adjustment method in which the central axis is aligned directly above the implant by referring to three voltages induced in three pickup coils symmetrically installed inside drive coil. Using the constructed position adjustment system, it was possible to automatically locate the position of the implant with accuracy below 1 mm by operating MFSD unit in two modes of coarse adjustment (rotary scanning) and fine adjustment (linear scanning).(3) Development of rotary scanning technique of body motion artifact reduction methodIt is considered that the relative position between MFSD unit and the implant is fluctuated due to the periodic physiological motions such as respiration and heartbeat induced artifact during treatment. Therefore, we cannot distinguish whether the change in pickup voltage is caused by the change in temperature of the implant around the therapeutic temperature, or by the change in distance between MFSD unit and the implant by the artifact. To overcome this problem, we proposed a body motion artifact reduction method by using rotary scanning technique on MFSD unit in a different period cycle from the periodic respiration and heartbeat. Using the difference in the frequency domain of spectral component of rotary scanning (signal) and that of the artifact (noise), only the target signal is extracted. Using the constructed verification system, we confirmed that regardless of the presence of the artifact, the change of the extracted power around the Curie point is sufficiently large to detect whether the temperature of the implant has reached the therapeutic temperature. In particular, in the case with the artifact the SN ratio for temperature measurement was ‒3.1 dB, whereas the SN ratio after reducing the artifact using the proposed method was enhanced significantly 38.7 dB.The thesis is composed of six chapters. In Chapter 1, we introduced the background and purpose of the research. Chapter 2 introduced the principle of hyperthermia such as its biological effects with respect to temperature, and heating methods used in hyperthermia. We then introduced the heating method used in this study named magnetic hyperthermia, and summarized the previous studies such as development of self-controlled heating mediator, wireless temperature measurement technique, and heating system for clinical application using the proposed wireless temperature measurement technique. In Chapter 3 to Chapter 5, we introduced the development and the obtained results from the evaluation experiments of (1) development of the implant of micro/nanomagnetic particles, (2) development of the automatic implant localization technique, and (3) development of the rotary scanning technique, respectively. Finally, we concluded the important results in this study and outlined future work in Chapter 6.

  48. Study on Wireless Temperature Measurement Induction Heating System using Magnetic Properties of Mixture of Resovist and Ferromagnetic Implant with Low Curie Temperature Peer-reviewed

    Fumitaka Aki, Tonthat Loi, Hajime Saito, Noboru Yoshimura, Kazutaka Mitobe

    IEEJ Transactions on Fundamentals and Materials　139　(1)　38-44　2019/01

    DOI： 10.1541/ieejfms.139.38 　

    ISSN： 0385-4205

    eISSN： 1347-5533

  49. Investigation of Magnetic Field Supply and Detection Unit for Hyperthermia

    Tonthat Loi, Takano Nagisa, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    Transactions of Japanese Society for Medical and Biological Engineering (Proceeding)　56　S351　2018/09

  50. Thermosensitive Ferromagnetic Implant for Hyperthermia Using a Mixture of Magnetic Micro-/Nanoparticles Peer-reviewed

    Loi Tonthat, Yoshiyuki Yamamoto, Fumitaka Aki, Hajime Saito, Kazutaka Mitobe

    IEEE Transactions on Magnetics　54　(7)　5400506-1-5400506-6　2018/07

    Publisher: Institute of Electrical and Electronics Engineers ({IEEE})

    DOI： 10.1109/TMAG.2018.2820061 　

    ISSN： 0018-9464

  51. Study of wireless temperature measurement induction heating system using magnetic properties of au‐coated ferromagnetic implant with low Curie temperature Peer-reviewed

    Aki Fumitaka, Loi Tonthat, Saito Hajime, Yoshimura Noboru, Mitobe Kazutaka

    Electronics and Communications in Japan　101　(6)　58-66　2018/06

    Publisher: Wiley-Liss Inc.

    DOI： 10.1002/ecj.12075 　

    ISSN： 1942-9541 1942-9533

  52. Thermosensitive Implant for Magnetic Hyperthermia by Mixing Micro-Magnetic and Nano-Magnetic Particles Peer-reviewed

    Loi Tonthat, Yoshiyuki Yamamoto, Fumitaka Aki, Hajime Saito, Kazutaka Mitobe

    IEEE Transactions on Magnetics　54　(6)　5400104-1-5400104-4　2018/06

    Publisher: Institute of Electrical and Electronics Engineers ({IEEE})

    DOI： 10.1109/TMAG.2018.2821271 　

    ISSN： 0018-9464

  53. Examination of the Influence on Precision of the Wireless Temperature Measurement Induction Heating System by 37 °C Constant Temperature Environment Peer-reviewed

    Fumitaka Aki, Tonthat Loi, Hajime Saito, Kazutaka Mitobe

    IEEE Transactions on Magnetics　54　(6)　2800303-1-2800303-3　2018/06

    Publisher: Institute of Electrical and Electronics Engineers ({IEEE})

    DOI： 10.1109/TMAG.2018.2815028 　

    ISSN： 0018-9464

  54. Study of Wireless Temperature Measurement Induction Heating System using Magnetic Properties of Au-coated Ferromagnetic Implant with Low Curie Temperature Peer-reviewed

    Fumitaka Aki, Tonthat Loi, Hajime Saito, Noboru Yoshimura, Kazutaka Mitobe

    IEEJ Transactions on Fundamentals and Materials　138　(3)　76-83　2018/03

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejfms.138.76 　

    ISSN： 0385-4205

    More details Close

    <p>In this paper, we aim to build wireless temperature measurement induction heating system for hyperthermia using "Au-coated Ferromagnetic Implant with Low Curie Temperature (Au-FILCT)". Using this system we clarified the distance-dependent characteristic of voltage used for detecting temperature in heating process of Au-FILCT under high-frequency magnetic field applied. The tumor temperature is measurable utilizing the property in which the magnetism of Au-FILCT changes depending on its temperature. We measured the voltage and temperature of Au-FILCT, while placed at distances of 1.0, 2.0, 3.0 and 4.0 cm from the top surface of the drive coil. We confirmed that the Au-FILCT was heated above the treatable temperature of 45℃ within 145.0 seconds up to the distance of 3.0 cm and the accuracy of voltage was improved with the S/N ratio 18.3 dB at 3.0 cm. In addition, the correlation of the voltage with either the temperature or distance was high. All the contribution ratios of their approximate expressions were above 0.97. We propose a method of estimating the temperature from the voltage measured even if the distance to the Au-FILCT is unknown, assuming the core body temperature is stable at about 37℃.</p>

  55. Position adjustment method and distance estimation method of magnetic field supply and detection unit for magnetic hyperthermia Peer-reviewed

    Loi Tonthat, Fumitaka Aki, Eiki Matsuda, Hajime Saito, Noboru Yoshimura, Kazutaka Mitobe

    IEEJ Transactions on Electrical and Electronic Engineering　12　(S2)　S3-S9　2017/12

    DOI： 10.1002/tee.22547 　

    ISSN： 1931-4973

    eISSN： 1931-4981

  56. Improvement of Heating Efficiency and Magnetization Property of Ferromagnetic Implant with Low Curie Temperature for Hyperthermia using Nano-Magnetic Fluid Peer-reviewed

    Loi Tonthat, Yoshiyuki Yamamoto, Fumitaka Aki, Hajime Saito, Kazutaka Mitobe

    Proceedings of the 8th International Conference on Materials Engineering for Resources　421-424　2017/10

  57. Development of automatic constant temperature heating control system using wireless temperature measurement for hyperthermia Peer-reviewed

    Matsuda, E., Fumitaka, A., Tonthat, L., Saito, H., Mitobe, K.

    Transactions of Japanese Society for Medical and Biological Engineering　54　(PROC)　P2-E01-1-P2-E01-2　2016/11

  58. Body Motion Artifact Reduction Method using Rotary Scanning for Accuracy Improvement of Wireless Temperature Measurement Peer-reviewed

    Tonthat Loi, Fumitaka Aki, Eki Matsuda, Hajime Saito, Noboru Yoshimura, Kazutaka Mitobe

    IEEJ Transactions on Fundamentals and Materials　136　(8)　529-534　2016/08

    Publisher: The Institute of Electrical Engineers of Japan

    DOI： 10.1541/ieejfms.136.529 　

    ISSN： 0385-4205

    More details Close

    In hyperthermia treatment, the accurate temperature measurement of tumor region is vital to determine the therapeutic effectiveness of heating. Conventional methods require thermal probes to be inserted invasively into tumor region. However, by using Ferromagnetic Implant with Low Curie Temperature (FILCT) as thermal probe, we have developed a wireless temperature measurement method that can noninvasively measure the temperature of tumor region from outside of the body. To make the approach feasible in clinical settings, challenges remain when dealing with body motion artifact. When the material is injected into tumor region, the relative position between the magnetic field supply and detection (MFSD) unit and the material is supposed to fluctuate with periodic respiration and heartbeat. In physical experiments, the FILCT temperature cannot be detected, because the detection voltage was buried by the artifact noise (SN ratio=-3.1 dB). Hence, this study proposed a body motion artifact reduction method by rotating scanning the MFSD unit in a different period cycle from body motion. By extracting the power spectrum synchronized with the rotary scanning, we confirmed that regardless of presence of body motion, the change of the power around Curie point is sufficiently large to detect whether treatment temperature has been reached.

  59. Rotary scanning wireless temperature measurement method for hyperthermia using ferromagnetic implants Peer-reviewed

    Loi Tonthat, Hajime Saito, Ryuhei Miyamoto, Masafumi Suzuki, Noboru Yoshimura, Kazutaka Mitobe

    IEEJ Transactions on Electrical and Electronic Engineering　10　(S1)　S1-S6　2015/10

    DOI： 10.1002/tee.22157 　

    ISSN： 1931-4973

    eISSN： 1931-4981

  60. Accuracy Improvement of Wireless Temperature Measurement Technique by Rotary Scan for Hyperthermia using Ferromagnetic Implant Peer-reviewed

    Loi Tonthat, Hajime Saito, Ryuhei Miyamoto, Masafumi Suzuki, Noboru Yoshimura, Kazutaka Mitobe

    Transactions of Japanese Society for Medical and Biological Engineering (Proceedings of 53rd Annual Conference of Japanese Society for Medical and Biological Engineering)　52　(Supplement)　O-90-O-91　2014/10/04

    Publisher: Japanese Society for Medical and Biological Engineering

    DOI： 10.11239/jsmbe.52.O-90 　

    ISSN： 1347-443X

    More details Close

    Soft-heating method is one type of hyperthermia that necrotizes malignant tumors in cancer treatment by means of heat generated by a ferromagnetic material. The magnetic permeability of ferromagnetic particle decreases immediately when its temperature increases over the Curie point (43°C). Therefore, we can concurrently use the ferromagnetic particles as a thermal probe for wireless temperature measurement during hyperthermia treatment. A challenge remains when dealing with body movement artifact as the relative position between the detection coil and the material is fluctuated by breathing or beating of the heart. As a result, the accuracy of temperature detection decreases. In this report we suggest and verify the validity of the new inspection system for the body movement artifact removal by regularly circling a unit of the magnetic field supply coil and the detection coil around the upper surface of the tumor region.

Show all ︎Show first 5

Misc. 2

  1. がん治療のための磁気ハイパーサーミア—Magnetic Hyperthermia for Cancer Treatment—特集 磁気を用いた生体診断技術と治療技術

    水戸部 一孝, トンタット ロイ, 桑波田 晃弘

    まぐね = Magnetics Japan　20　(2)　81-86　2025

    Publisher: 東京 : 日本応用磁気学会

    ISSN： 1880-7208

  2. Non-invasive treatment of lymph node metastasis with magnetic hyperthermia technology in murine tumor model

    Takayuki Kagami, Ariunbuyan Sukhbaatar, Akihiro Kuwahata, Loi Tonthat, Riku Shinohara, Tetsuya Kodama, Shin Yabukami

    CANCER SCIENCE　115　2150-2150　2024/03

    ISSN： 1347-9032

    eISSN： 1349-7006

Presentations 96

  1. Enhancing the Sensitivity of Frequency-Driven Thin-Film Magnetic Field Sensors and Near-Field Magnetic Measurement in Wireless Power Transfer Systems Invited

    Loi Tonthat, Ryota Suzuki, Junichi Honda, Jerdvisanop Chakarothai, Katsumi Fujii, Shin Yabukami

    Survey Special Committee on Sensing Systems Utilizing AI-Based Magnetic Sensor Technology (Research Introduction)　2025/03/31

  2. Highly Sensitive Bio-Detection Utilizing Magnetic Phase Transition by Aggregates of Magnetic Nanoparticles and Biomolecules Invited

    Loi Tonthat, Koki Kaneko, Youcheng Pu, Toru Murayama, Amane Ban, Junichi Honda, Kazuhiko Okita, Shin Yabukami

    2025 IEEJ Annual Meeting (Meiji University)　2025/03/20

  3. High-frequency-carrier type thin-film magnetic sensor with slit-patterned CoNbZr Invited

    Loi Tonthat, Ryota Suzuki, Shin Yabukami

    International Symposium on Integrated Magnetics 2025 (iSIM 2025 is a satellite event to Joint MMM-Intermag 2025) (New Orleans, Louisiana, USA)　2025/01/12

  4. Development of Thin-Film Magnetic Field Sensors for Near-Field Measurement

    Loi Tonthat, Ryota Suzuki, Jerdvisanop Chakarothai,, Katsumi Fujii, Shin Yabukami

    Workshop of Magnetics (IEEJ workshop Section A)　2024/10/25

  5. Enhancing Magneto-Optical Properties of Heterodimer Au-Fe3O4 Nanoparticles International-presentation Invited

    Loi Tonthat, Shin Yabukami, Akihiro Kuwahata, Tomoyuki Ogawa

    5th International Symposium on Advanced Magnetic Materials and Applications (ISAMMA), (Quang Binh, Vietnam) Invited & Committee　2024/08/05

    More details Close

    Dear Colleagues, It is my great pleasure and honor to extend to you a warm invitation to attend the 5th International Symposium on Advanced Magnetic Materials and Applications (ISAMMA), which will be held from August 4 to 7, 2024 in Quang Binh Province - an exceptional location for the congress and dream vacation destination. ISAMMA 2024 aims to bring together leading scientists and engineers working on magnetic materials and their applications and facilitate the exchange of recent results and new ideas around the topics. This symposium will feature plenary, keynote, and invited talks on topical areas of magnetism from the world-leading scientists, including five IEEE Magnetics Distinguished Lecturers. It will also offer a unique opportunity to network, allowing you to meet and interact with colleagues and friends, as well as sponsors and exhibitors. I hope you will join us for an excellent science symphony and spend a little more time enjoying the spectacular and unique beauty of Quang Binh province. Sincerely, Nguyen Huu Duc General Chair of ISAMMA 2024 President of Vietnam Magnetics Society

  6. Efficient Synthesis and Magneto-Optical Enhancement of Au–Fe3O4 Hetero-dimer Nanoparticles with Triiron Dodecacarbonyl International-presentation

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    2024 IEEE International Magnetics Conference (INTERMAG 2024, Rio de Janeiro, Brazil)　2024/05/07

  7. Dumbbell-like Au–Fe3O4 Nanoparticles for Magnetic Hyperthermia International-presentation

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    The 68th Annual Conference on Magnetism and Magnetic Materials (MMM2023) @ Dallas, TX, USA 2023　2023/11/02

  8. Method for measuring magnetic susceptibility of magnetic nanoparticles up to millimeter-wave frequency range

    Y. Pu, L. Tonthat, T. Murayama, K. Okita, S. Yabukami, T. Ishijima, M. Sato, S. Sugimoto

    令和 5 年度スピニクス特別研究会　2023/10/27

  9. Multifunctional Ultrasmall Au-Fe3O4 Nanoparticles for Cancer Therapy International-presentation Invited

    Loi Tonthat

    The 4th International Workshop on Advanced Materials and Devices 2023 (IWAMD 2023) Thai Nguyen University, Vietnam　2023/08/11

    More details Close

    Welcome to IWAMD 2023! The 4th International Workshop on Advanced Materials and Devices (IWAMD 2023) will take place at Thai Nguyen University, Vietnam, from August 10 to 13, 2023. Following the success of its conference series, IWAMD 2023 will promote a global collaboration with great scientific activities. It will bring together leading experts from various scientific disciplines in materials science, physics, chemistry, and biology, to discuss new discoveries and exciting advances that involve a wide variety of materials ranging from electronics to energy and quantum computation, nanotechnologies, and methodologies. Members of the international scientific community are invited to participate and contribute to the technical sessions of the workshop, which will include oral and poster presentations. Workshop Chairmen Prof. Nguyen Hoang Luong, VNU University of Science, Vietnam Prof. Yoji Shibutani, Osaka University, Japan

  10. Ultrasmall Fe3O4@Au Composite Nanoparticles with Different Sizes of Fe3O4 for Magnetic Hyperthermia

    Loi Tonthat, Tomoyuki Ogawa, Shin Yabukami

    2023 IEEE International Magnetics Conference (INTERMAG, May 15-19, 2023 @ Sendai, Japan)　2023/05/18

  11. Ultrafast Heating Rate of Ultrasmall Gold-coated Iron Oxide Magnetic Nanoparticles by Ferromagnetic Resonance

    Loi Tonthat, Akihiro Kuwahata, Tomoyuki Ogawa, Shin Yabukami

    2023 IEEE International Magnetics Conference (INTERMAG, May 15-19, 2023 @ Sendai, Japan)　2023/05/17

  12. 磁性微粒子への直接通電による 高感度透磁率検出

    益子朝日, Loi Tonthat, 桑波田晃弘, 薮上 信, 小林伸聖, 杉本 諭

    第49回 日本磁気学会学術講演会　2025/09/19

  13. 搬送波抑制回路を用いたスリット 付き 高周波駆動薄膜磁界センサによる 磁界検出

    田澤直弥, 鈴木椋太, 本田順一, トンタット ロイ, 青木英恵, 桑波田晃弘, 薮上 信

    第49回 日本磁気学会学術講演会　2025/09/19

  14. 磁性ナノ粒子の強磁性共鳴を利用したタンパク質検出

    舛井亮哉, 村山 徹, トンタット ロイ, 青木英恵, 桑波田晃弘, 薮上 信

    第49回 日本磁気学会学術講演会　2025/09/17

  15. 生体内における磁性ナノ粒子の誘導形状磁気異方性の形成と評価

    上島優也, 桑波田晃弘, 島野大輝, スフバートル アリウンブヤン, トンタット ロイ, 小玉哲也, 薮上 信

    第49回 日本磁気学会学術講演会　2025/09/17

  16. 磁気温熱療法のための磁気高調波信号を用いた温度計測

    篠原 陸, トンタット ロイ, 桑波田晃弘, 薮上 信

    第49回 日本磁気学会学術講演会　2025/09/17

  17. 磁性ナノ粒子と微生物の抗原抗体反応凝集体の分散性を利用した微生物検出

    薮上 信, 沖田和彦, 村山 徹, TON THAT LOI, 遠竹駿大

    マグネティックス研究会　2025/09/11

  18. 磁性ナノ粒子とタンパク質の抗原抗体反応凝集体の磁気的特性とタンパク質検出

    北風光稀, 村山 徹, TON THAT LOI, 薮上 信, 小澤洋平, 岡本宏史, 亀井 尚, 田中深雪, 田中良和, 阿部高明

    マグネティックス研究会　2025/09/11

  19. Directional-enhancement of magnetic resonance in soft magnetic CoNbZr films with uniaxial magnetic anisotropy

    H. Kijima-Aoki, L. Tonthat, S. Yabukami

    IcAUMS2025 : International Conference of Asian Union of Magnetics Societies (Okinawa, Japan)　2025/04/21

  20. High-frequency drive type thin film sensor using coplanar line with slit

    R. Suzuki, L. Tonthat, J. Honda, H. Kijima-Aoki, 〇S. Yabukami

    IcAUMS2025 : International Conference of Asian Union of Magnetics Societies (Okinawa, Japan)　2025/04/22

  21. Observation of magnetic nanoparticles-protein aggregates and highly sensitive protein detection

    K. Kaneko, A. Ban, T. Murayama, L. Tonthat, S. Yabukami, M. Tanaka, Y. Tanaka, T. Abe

    2025 Joint MMM-Intermag Conference (New Orleans, Louisiana, USA)　2025/01/17

  22. Evaluation of cytokeratin in lymph node metastasis using magnetic nanoparticles and protein aggregates

    Shin Yabukami, Toru Murayama Koki, Kaneko Amane Ban, Loi Ton That, Yohei Ozawa, Hiroshi Okamoto, Takashi Kamei, Miyuki Tanaka, Yoshikazu Tanaka, Takaaki Abe

    2025 Joint MMM-Intermag Conference (New Orleans, Louisiana, USA)　2025/01/15

  23. Rapid Detection of Bacteria in Saliva using Magnetic Susceptibility

    S. Yabukami, A. Ban, T. Murayama, K. Okita, S. Tohtake, L. Tontha, Y. Ozawa, S. Asamitsu, H. Okamoto, T. Kamei, T. Abe

    International Symposium on Integrated Magnetics 2025 (iSIM 2025 is a satellite event to Joint MMM-Intermag 2025) (New Orleans, Louisiana, USA)　2025/01/13

  24. An Ultra-Broadband Measurement of Magnetic Nanoparticle and Protein

    S. Yabukami, R. Masui, T. Murayama, J. Honda, L. Tonthat, K. Okita, A. Kuwahata

    International Symposium on Integrated Magnetics 2025 (iSIM 2025 is a satellite event to Joint MMM-Intermag 2025) (New Orleans, Louisiana, USA)　2025/01/13

  25. An Ultra-Broadband Magnetic Susceptivity Evaluation of magnetic nanoparticle and protein

    Shin Yabukami, Junichi Honda, Toru Murayama, Loi Tonthat, Kazuhiko Okita

    2024 IEEE International Magnetics Conference (INTERMAG 2024, Rio de Janeiro, Brazil)　2024/05/09

  26. Magnetic response of the magnetic nanoparticles/protein aggregation for protein detection

    Koki Kaneko, Toru Murayama, Junichi Honda, Loi Tontha, Kazuhiko Okita, Shin Yabukami

    The 68th Annual Conference on Magnetism and Magnetic Materials (MMM2023) @ Dallas, TX, USA　2023/11/01

  27. Ferromagnetic Resonance-based Heat Dissipation in Dumbbell-like Au–Fe3O4 Nanoparticles International-presentation

    Loi Tonthat, Akihiro Kuwahata, Shin Yabukami

    The 68th Annual Conference on Magnetism and Magnetic Materials (MMM2023) @ Dallas, TX, USA　2023/11/01

  28. Sensitivity Evaluation of High-Frequency Driven Thin-Film Magnetic Field Sensors Using Sideband Observation

    Ryota Suzuki, Masaya Sakamoto, Tomoya Ishihara, Junichi Honda, Loi Tonthat, Shin Yabukami

    2023 Spinic Special Research Symposium　2023/10/27

  29. 磁気渦構造を持つ中空構造Fe3O4粒子の磁気加熱特性（28aPS-15）

    秋山 遥, L. Tonthat, 桑波田晃弘, 薮上 信, 小林 悟

    The 47th Annual Conference on MAGNETICS (Osaka University, Toyonaka Campus)　2023/09/28

  30. 磁性ナノ 粒子の応答性を利用したタンパク 質検出（27pE-6）

    金子晃基, 村山 徹, 本多順一, L. Tontha, 沖田和彦, 薮上 信

    The 47th Annual Conference on MAGNETICS (Osaka University, Toyonaka Campus)　2023/09/27

  31. Enhancing Leaked Magnetic Field Measurement with Thin Film Magnetic Field Sensor (29pD-4)

    L. Tonthat, 鈴木椋太, 本多順一, 沖田和彦, J. Chakarothai, 藤井勝巳, 薮上 信

    The 47th Annual Conference on MAGNETICS (Osaka University, Toyonaka Campus)　2023/09/29

  32. Non-invasive treatment of lymph node metastasis with magnetic hyperthermia technology in murine tumor model

    Takayuki Kagami, Ariunbuyan Sukhbaatar, Akihiro Kuwahata, Loi Tonthat, Riku Shinohara, Shin Yabukami, Tetsuya Kodama

    The 82nd Annual Meeting of the Japanese Cancer Association (PACIFICO Yokohama)　2023/09/23

  33. Development of Multifunctional Ultrasmall Au-Fe3O4 Nanoparticles for Cancer Therapy Invited

    Loi Tonthat

    9th Annual World Congress of Advanced Materials 2023 (WCAM-2023, Tokyo, Japan) https://www.bitcongress.com/wcam2022-japan/index.asp　2023/05/10

  34. Structural and Electrical Characteristics of Solution-Coated Thin Films Composed of Semiconducting Organic Molecular Compounds and Fe3O4 Nanoparticles for Near-infrared Photoelectric Conversion

    Naomi Uchiyama, Yosei Shibata, Loi Tonthat, Yuji Matsuura

    The 5th Optical Wireless and Fiber Power Transmission Conference (OWPT2023)　2023/04/21

  35. Method of Measuring Magnetic Susceptibility of Magnetic Nanoparticles up to 67 GHz

    Youcheng Pu, Loi Tonthat, Toru Murayama, Kazuhiko Okita, Shin Yabukami

    電気学会マグネティックス研究会　2023/01/20

  36. Method for Measuring Magnetic Susceptibility of Magnetic Nanoparticles up to Millimeter-Wave Frequency Range (OOB-05)

    Y. Pu, Y. Watanabe, L. Ton That, T. Murayama, K. Okita, S. Yabukami

    67th Annual Conference on Magnetism and Magnetic Materials (MMM 2022) Minnesota, America　2022/10/31

  37. Synthesis and antigen-antibody reaction of ultrasmall FeCo nanoparticles (QOA-04)

    Loi Tonthat, Toru Murayama, Nobukiyo Kobayashi, Shin Yabukami, Wakako Ikeda-Ohtsubo, Ken Ichi Arai

    67th Annual Conference on Magnetism and Magnetic Materials (MMM 2022) Minnesota, America　2022/11/01

  38. Development of gold-coated magnetic nanoparticles as a theranostic agent for magnetic hyperthermia and micro-CT imaging applications (QOA-08)

    Loi Tonthat, Mone Kimura, Tomoyuki Ogawa, Narufumi Kitamura, Yoshio Kobayashi, Kohsuke Gonda, Shin Yabukami

    67th Annual Conference on Magnetism and Magnetic Materials (MMM 2022) Minnesota, America　2022/11/01

  39. Development of magnetic nanoparticles for biomedical applications (14-B-a1-6)

    Tonthat Loi, Tomoyuki Ogawa, Shin Yabukami

    令和 4 年電気学会 基礎・材料・共通部門大会（鹿児島県 西之表市民会館）　2022/09/14

  40. A simple antigen-antibody reaction using ultrasmall FeCo nanoparticles (08pD-12)

    L. Tonthat, 村山 徹, 小林伸聖, 薮上 信, 大坪和香子, 荒井賢一

    The 46th annual Conference on MAGNETICS in Japan (Shinshu University, Nagano)　2022/09/08

  41. Development of gold-coated magnetic nanoparticles for magnetic hyperthermia and micro-CT imaging applications (08pD-5)

    Loi Tonthat, 小川智之, 北村成史, 小林芳男, 権田幸祐, 薮上 信

    The 46th annual Conference on MAGNETICS in Japan (Shinshu University, Nagano)　2022/09/08

  42. Magnetic Hyperthermia Application for Cancer Treatment (Committee member & Invited speaker) Invited

    Loi Tonthat

    2nd Global Summit and Expo on Magnetism and Magnetic Materials (GSEMMM2022, Copenhagen, Denmark) https://www.thescientistt.com/magnetism-magnetic-materials/2022/　2022/06/13

  43. Development of Magnetic Hyperthermia System for Cancer Therapy using Functionalized Magnetic Micro/Nano Particles (Invited) Invited

    Loi Tonthat

    Symposium on World Cancer Research 2022 (SWCR 2022, Singapore) https://www.symwcr.com/　2022/05/07

  44. Development of temperature and position detection techniques for magnetic particles for magnetic hyperthermia (Invited) Invited

    Loi Tonthat

    International Meet on Magnetism and Magnetic Materials (MAGNETISMMEET2022, Tokyo, Japan) https://www.albedomeetings.com/magnetismmeet/index.php#　2022/04/18

  45. Temperature Dependence of DC and AC Magnetization of Magnetic Particles with Low Curie Temperature for Magnetic Hyperthermia (IPE-08)

    Loi Ton That, Kazutaka Mitobe, Shin Yabukami

    2022 Joint MMM-Intermag Conference　2022/01

  46. Simplified fabrication of magnetic nanoparticles with directly adsorbed antibodies for bacteria detection (IPE-09)

    Tsuyoshi Yoneyama, Toru Murayama, Loi Ton That, Akihiro Kuwahata, Shin Yabukami, Yuya Sato, Yuji Teramura, Wakako Ikeda-Ohtsubo, Tomoyuki Ogawa

    2022 Joint MMM-Intermag Conference　2022/01

  47. Development of Magnetic Hyperthermia Application for Cancer Treatment (Invited) Invited

    Loi Tonthat

    2nd International Conference on Cancer & Oncology (Oncology 2021, Zurich, Switzerland) https://oncology.prideconferences.com/　2021/12/02

  48. Development of magnetic hyperthermia system for cancer thermotherapy using functionalized magnetic particles Invited

    Loi Tonthat

    2nd World Nanotechnology Summit (Worldnano-2021, Miami, USA) https://www.phronesisonline.com/nano-technology-summit/index.php　2021/11/16

  49. Temperature-Controlled Heating for Magnetic Hyperthermia in Vivo (21-3-18)

    Akihiro Shikano, Loi Tonthat, Akihiro Kuwabata, Ariunbuyan Sukhbaatar, Tetsuya Kodama, Shin Yabukami

    2021 Spinic Special Research Symposium　2021/10/27

  50. Development of Magnetic Hyperthermia Application: Current Status and Future Directions (Invited) Invited

    Loi Tonthat

    Global Summit and Expo on Magnetism and Magnetic Materials (GSEMMM2021, Paris, France) https://www.thescientistt.com/magnetism-magnetic-materials/　2021/09/20

  51. 抗体を直接吸着させた磁性ナノ粒子の抗原抗体反応の評価（01aA-11）

    米山 毅, 村山 徹, トンタット ロイ, 桑波田 晃弘, 薮上 信, 佐藤 佑哉, 寺村 裕治, 大坪 和香子, 小川 智之

    第45回日本磁気学会学術講演会　2021/09/01

  52. 磁気ハイパーサーミア用 PID 加熱制御システムの開発（31aA-6）

    鹿野 晃弘, トンタット ロイ, 桑波田 晃弘, 薮上 信

    第45回日本磁気学会講演会　2021/08/31

  53. 磁気温熱療法における感温磁性微粒子のワイヤレス温度検知技術の評価（1G03）

    北村 大河, 鹿野 晃弘, トンタット ロイ, 桑波田 晃弘, 薮上 信

    2021年度電気関係学会東北支部連合大会　2021/08/26

  54. A Simple Localization Method of Magnetic Particles for Hyperthermia Therapy using Figure-8 Coil (JP-13)

    Loi Ton That, Ryuichi Hirota, Taiga Kitamura, Kazuhiko Okita, Shin Yabukami

    INTERMAG 2021 Virtual Conference (Lyon, France - Online)　2021/04/26

  55. A Constant Temperature Control Technology for Hyperthermia Therapy using Magnetic Particles (Automatic On-Off Control) (ME-3-5)

    トンタット ロイ, 鹿野 晃弘, 薮上 信

    第54回日本生体医工学会東北支部大会　2021/01/23

  56. マイクロストリップ線路型プローブによる透磁率・誘電率の同時測定（14pD-2）

    能澤昂平, 高橋翔平, 沖田和彦, Loi Tonthat, 薮上 信, 佐藤光晴, 杉本 諭

    The 44th Annual Conference on MAGNETICS in Japan　2020/12/14

  57. Development of heating element and techniques for detecting its temperature and position for hyperthermia（15aB-5） (Invited) Invited

    Loi Tonthat, Kazutaka Mitobe, Shin Yabukami

    The 44th Annual Conference on MAGNETICS in Japan (Symposium)　2020/12/15

  58. Simultaneous Measurement of Permeability and Permittivity using a Flexible Microstrip Line-Type Probe up to 67 GHz (H4-03)

    S. Yabukami, K. Nozawa, S. Takahashi, L. Tonthat, K. Okita, M. Sato, S. Sugimoto

    2020 Annual Conference on Magnetism and Magnetic Materials (MMM 2020 Online Conference)　2020/11/04

  59. Effect of applied magnetic field on permeability and heating efficiency of multifunctional micro/nano-magnetic particles for hyperthermia therapy (K5-03)

    Loi Tonthat, Yoshiyuki Yamamoto, Kazutaka Mitobe, Shin Yabukami

    2020 Annual Conference on Magnetism and Magnetic Materials (MMM 2020 Online Conference)　2020/11/04

  60. Development of elemental technologies for magnetic hyperthermia in cancer treatment (AP3-7-TE-002) International-presentation

    Loi Tonthat, Fumitaka Aki, Kazutaka Mitobe, Shin Yabukami, Yoshiyuki Yamamoto

    11th Asian Pacific Conference on Medical and Biological Engineering (APCMBE 2020)　2020/05/27

  61. Impact of complex permeability measurements up to millimeter-wave frequency range on future information technology and bio-magnetic diagnosis. (Invited) (DG-01) Invited

    Shin Yabukami, Kohei Nozawa, Loi Ton That, Kazuhiko Okita

    The International Magnetics Conference (INTERMAG 2020) (Montréal, Canada) (accepted paper, Intermag 2020 is cancelled due to COVID-19)　2020/05/06

  62. An automatic localization system of magnetic particles for hyperthermia in cancer treatment (GF-04) International-presentation

    Loi Tonthat, Kazutaka Mitobe, Shin Yabukami

    The International Magnetics Conference (INTERMAG 2020) (Montréal, Canada) (accepted paper, Intermag 2020 is cancelled due to COVID-19)　2020/05/08

  63. Localization technique of magnetic particles for hyperthermia in cancer treatment

    Ton That Loi

    Mini-Workshop on Nano magnets: Properties and Applications (Bengaluru,India)　2020/02/18

  64. スイッチ磁界に対する磁性ナノ粒子の応答性を利用した細菌検出

    高橋隼之介, トンタットロイ, 小野寺英彦, 沖田和彦, 藪上信, 横田琴音, 古谷真衣子, 金高弘恭, 三浦由則, 髙橋英樹, 渡部芳彦, 秋山利津子

    電気学会マグネティクス研究会　2019/12/27

  65. マイクロストリッププローブによる磁性薄膜の高周波透磁率測定

    能澤昂平, 沖田和彦, トンタットロイ, 薮上信, 遠藤恭, 島田寛, 斉藤伸, 内海良一

    マグネティックス研究会2019（大阪大学）　2019/12/05

  66. Evaluation of AC magnetization and heat dissipationof Au-coated Fe2O3 particles

    Tsuyoshi Yamaminami, Shota Kobayashi, Loi Tonthat, Kazutaka Mitobe, Shin Yabukami, Tsutomu Yamada, Satoshi Ota, Yasushi Takemura

    The Forth International Workshop on Magnetic Bio-Sensing (IWMBS2019) (Taipei, Taiwan)　2019/11/29

  67. Development of thermosensitive magnetic micro/nano particles for hyperthermia

    TON THAT LOI

    India-Japan Joint Research Project (Japan Society for the Promotion of Science) / Seminar (Sendai, Japan)　2019/11/13

  68. Very Broad Bandwidth Permeability Measurement of Thin Film using a Flexible Microstrip Line-type Probe up to 67 GHz International-presentation

    Kouhei Nozawa, Loi Tonthat, Kazuhiko Okita, Shin Yabukami, Yasushi Endo, Yutaka Shimada, Shin Saito, Ryoichi Utsumi

    2019 Annual Conference on Magnetism and Magnetic Materials (Las Vegas, America)　2019/11/04

  69. A Highly Sensitive Coplanar Line Thin Film Sensor for Magnetocardiographic Measurement International-presentation

    Haruhi Kudo, Heroaki Uetake, Hidehiko Onodera, Loi Tonthat, Shin Yabukami, Junichi Hayasaka, Ken Ichi Arai

    2019 Annual Conference on Magnetism and Magnetic Materials (Las Vegas, America)　2019/11/04

  70. A Simple and Rapid Detection System of Oral Bacteria in Liquid Phase for Point-of-Care Diagnostics using Magnetic Beads International-presentation

    Loi Ton That, Shunnosuke Takahashi, Hidehiko Onodera, Kazuhiko Okita, Shin Yabukami, Kotone Yokota, Maiko Furuya, Hiroyasu Kanetaka, Yoshinori Miura, Hideki Takahashi

    2019 Annual Conference on Magnetism and Magnetic Materials (Las Vegas, America)　2019/11/04

  71. Measurement of bacteria using magnetic beads by switching magnetic field

    S. Takahashi, Loi Tonthat, H. Onodera, S. Yabukami, K. Yokota, M. Furuya, H. Kanetaka, Y. Miura, H. Takahashi, K. Watanabe, R. Akiyama

    Special Spinics Meeting 2019 ( Nihon University, Fukushima)　2019/10/15

  72. Development of Thermosensitive Magnetic Micro/Nano Particles for Hyperthermia

    Loi Tonthat, Kazutaka Mitobe, Shin Yabukami

    Special Spinics Meeting 2019 ( Nihon University, Fukushima)　2019/10/15

  73. Evaluation of AC magnetization and heat dissipation of Au coated Fe2O3 particles

    Tsuyoshi Yamaminami, Shota Kobayashi, Loi Tonthat, Kazutaka Mitobe, Shin Yabukami, Tsutomu Yamada, Satoshi Ota, Yasushi Takemura

    The 43rd Annual Conference on MAGETICS in Japan　2019/09/25

  74. Permeability Measurements of Thin Film Using a Flexible Microstrip Line-Type Probe Up To 67 GHz

    K. Nozawa, L. Tonthat, S. Yabukami, S. Saito, Y. Endo, H. Shimada

    The 43rd Annual Conference on MAGETICS in Japan　2019/09/25

  75. Flip-chip bonded high-frequency thin-film magnetic field sensor

    H. Kudo, H. Uetake, H. Onodera, L. Tonthat, S. Yabukami, J. Hayasaka, K. I. Arai

    The 43rd Annual Conference on MAGETICS in Japan　2019/09/25

  76. Measurement of bacteria using magnetic beads by switching magnetic field

    S. Takahashi, L.Tonthat, H. Onodera, K. Okita, S. Yabukami, K. Yokota, M. Furuya, H. Kanetaka, Y. Miura, H. Takahashi

    The 43rd Annual Conference on MAGETICS in Japan　2019/09/25

  77. Wireless detection technology of magnetic particle position and temperature for cancer magnetic hyperthermia Invited

    Loi Tonthat, Kazutaka Mitobe, Shin Yabukami

    200th Spinics Workshop（Sendai，Japan）　2019/09/04

  78. Investigation of magnetic field application detection unit for wireless temperature detection technology for hyperthermia

    Hirokazu Yamamoto, Tonthat Loi, Aki Fumitaka, Kazutaka Mitobe

    58th Annual Conference of Japanese Society for Medical and Biological Enginering　2019/06/06

  79. Construction of wireless temperature measurement and automatic constant temperature heating system for hyperthermia using gold-coated thermosensitive magnetic material

    Aki Fumitaka, Tonthat Loi, Hajime Saito, Kiyoyuki Yamazaki, Kazutaka Mitobe

    58th Annual Conference of Japanese Society for Medical and Biological Enginering　2019/06/06

  80. Research and development on wireless detection techniques of position and temperature information of thermosensitive magnetic particles for magnetic hyperthermia

    Loi Tonthat, Fumitaka Aki, Yoshiyuki Yamamoto, Hajime Saito, Shin Yabukami, Kazutaka Mitobe

    58th Annual Conference of Japanese Society for Medical and Biological Enginering　2019/06/06

  81. Development of Wireless Temperature and Position Monitoring for Magnetic Hyperthermia using Pickup Coils International-presentation

    Tonthat Loi, Yamamoto Yoshiyuki, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    3rd International Workshop on Magnetic Bio-Sensing (IWMBS 2018)　2018/11/05

  82. Effects of Magnetic Field on Permeability and Heating Properties of Hyperthermia Implant using Micro-/Nano-Magnetic Particles International-presentation

    Tonthat Loi, Yamamoto Yoshiyuki, Saito Hajime, Mitobe Kazutaka

    40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'18)　2018/07/17

  83. Investigation of Magnetic Field Supply and Detection Unit for Hyperthermia

    Loi Tonthat, Nagisa Takano, Fumitaka Aki, Hajime Saito, Kazutaka Mitobe

    57th Annual Conference of Japanese Society for Medical and Biological Enginering　2018/06/19

  84. Examination of the Influence on Precision of the Wireless Temperature Measurement Induction Heating System by 37°C Constant Temperature Environment International-presentation

    Aki Fumitaka, Tonthat Loi, Saito Hajime, Mitobe Kazutaka

    4th International Symposium on Advanced Magnetic Materials and Applications (ISAMMA 2017)　2017/12/10

  85. Thermosensitive Implant for Magnetic Hyperthermia by Mixing Micromagnetic and Nanomagnetic Particles International-presentation

    Tonthat Loi, Yamamoto Yoshiyuki, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    4th International Symposium on Advanced Magnetic Materials and Applications (ISAMMA 2017)　2017/12/10

  86. Magnetic Hyperthermia Implant: A Mixture of Micro/Nano Magnetic Particles

    Tonthat Loi, Yamamoto Yoshiyuki, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    2017/12/02

  87. Improvement of Heating Efficiency and Magnetization Property of Ferromagnetic Implant with Low Curie Temperature for Hyperthermia using Nano-Magnetic Fluid International-presentation

    Tonthat Loi, Yamamoto Yoshiyuki, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    8th International Conference on Materials Engineering for Resources (ICMR 2017 AKITA)　2017/10/25

  88. Position Adjustment Method of Magnetic Field Supply and Detection Unit for Magnetic Hyperthermia using Ferromagnetic Implant International-presentation

    Tonthat Loi, Aki Fumitaka, Saito Hajime, Mitobe Kazutaka

    39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’17)　2017/07/11

  89. Study of Induction Heating Approach with Wireless Temperature Measurement Technique for Hyperthermia International-presentation

    Aki Fumitaka, Saito Hajime, Tonthat Loi, Matsuda Eki, Mitobe Kazutaka

    International Conference on Electrical Engineering 2016 (ICEE2016)　2016/07/03

  90. Study on Shortening Latency in Body Motion Artifact Reduction Method for Accuracy Improvement of Wireless Temperature Measurement by using Symmetrical Multi-pickup coils International-presentation

    Tonthat Loi, Saito Hajime, Mitobe Kazutaka

    International Conference on Electrical Engineering 2016 (ICEE2016)　2016/07/03

  91. Development of Automatic Constant Temperature Heating Control System using Wireless Temperature Measurement for Hyperthermia

    Eiki Matsuda, Fumitaka Aki, Loi Tonthat, Hajime Saito, Kazutaka Mitobe

    55th Annual Conference of Japanese Society for Medical and Biological Enginering　2016/04/26

  92. Body Artifact Reduction Method using Rotary Scanning for Accuracy Improvement of Wireless Temperature Measurement in Hyperthermia

    Loi Tonthat, Hajime Saito, Kazutaka Mitobe

    平成 27 年度 情報処理学会東北支部研究会　2015/12/01

  93. Accuracy improvement of wireless temperature measurement technology by rotary scanningFor hyperthermia using thermosensitive magnetic materials

    2015/09/28

  94. Bias reduction method for wireless temperature measurement technology in hyperthermia using thermosensitive magnetic materials

    Medical and bioengineering Meeting (Institute of Electrical Engineers of Japan)　2015/03/28

  95. Noise suppression method for Wireless Temperature Measurement for Hyperthermia Treatment using FILCT International-presentation

    Mitobe Kazutaka, Miyamoto Ryuhei, Tonthat Loi, Aki Fumitaka, Saito Hajime

    7th Biomedical Engineering International Conference (BMEiCON)　2014/11/26

  96. Accuracy Improvement of Wireless Temperature Measurement Technique by Rotary Scan for Hyperthermia using Ferromagnetic Implant

    Tonthat Loi, Saito Hajime, Miyamoto Ryuhei, Suzuki Masafumi, Yoshimura Noboru, Mitobe Kazutaka

    53rd Annual Conference of Japanese Society for Medical and Biological Engineering　2014/06/24

Show all Show first 5

Industrial Property Rights 4

  1. Implants for Magnetic Hyperthermia Treatment

    Kazutaka Mitobe, Loi Tonthat, Yoshiyuki Yamamoto, Hajime Saito

    特許第6964865号

    Property Type: Patent

    Holder:

  2. Magnetic Material Localization System and Method

    Kazutaka Mitobe, Loi Tonthat, Hajime Saito

    特許第6964859号

    Property Type: Patent

    Holder:

  3. Method for Correcting Luminescence Quantity of Bioluminescent Tissue

    Yabukami Shin, Kodama Tetsuya, Kuwahata Akihiro, Ton That Loi, Sukhbaatar Ariunbuyan

    Property Type: Patent

  4. Magnetic heating system and magnetic heating control method

    薮上 信, 小玉 哲也, 桑波田 晃弘, Ton That Loi, Sukhbaatar Ariunbuyan

    Property Type: Patent

Research Projects 23

  1. Application of thin-film magnetic field sensor to electromagnetic noise measurement (continued for 3rd year)

    TON THAT LOI

    Offer Organization: Tohoku University － National Institute of Information and Communications Technology

    System: 2025 Tohoku University-NICT Matching Research Support Project

    Institution: Tohoku University

    2025/04 - 2026/03

  2. Development of Innovative Magnetic Bio-Detection Technology Using Fe₃O₄@Au Nanoparticles and a High-Sensitivity Thin-Film Magnetic Sensor

    Tonthat Loi

    Offer Organization: Group of Electrical Engineering, Communication Engineering, Electronic Engineering, and Information Engineering (ECEI), Tohoku University

    System: Support Program for Young/Female Faculty Members

    Institution: Tohoku University

    2024/12 - 2025/03

  3. Application of thin-film magnetic field sensor to electromagnetic noise measurement (continued for 2nd year)

    TON THAT LOI

    Offer Organization: Tohoku University － National Institute of Information and Communications Technology

    System: 2024 Tohoku University-NICT Matching Research Support Project

    Institution: Tohoku University

    2024/04 - 2025/03

  4. Development of nanotheranostic agent and application to cancer treatment and diagnosis

    TON THAT LOI

    Offer Organization: The Ministry of Education, Culture, Sports, Science and Technology

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists（23K17222）

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2023/04 - 2025/03

  5. Development of Nanotheranostic Agents and Their Applications in Cancer Treatment and Diagnosis (continue)

    Tonthat Loi

    Offer Organization: Group of Electrical Engineering, Communication Engineering, Electronic Engineering, and Information Engineering (ECEI), Tohoku University

    System: Support Program for Young/Female Faculty Members

    Institution: Tohoku University

    2023/12 - 2024/03

  6. Application of thin-film magnetic field sensor to electromagnetic noise measurement

    TON THAT LOI

    Offer Organization: Tohoku University － National Institute of Information and Communications Technology

    System: 2023 Tohoku University-NICT Matching Research Support Project

    Institution: Tohoku University

    2023/04 - 2024/03

  7. タンパク質検出用簡易迅速IoTセンサの開発

    薮上 信(代表), 桑波田晃弘, TON THAT LOI, 他

    Offer Organization: 国立研究開発法人科学技術振興機構

    Category: JST(A-STEPﾄﾗｲｱｳﾄ)

    Institution: 研究成果最適展開支援プログラム Ａ-ＳＴＥＰ

    2022/10 - 2024/03

  8. Development of Nanotheranostic Agents and Their Applications in Cancer Treatment and Diagnosis

    Tonthat Loi

    Offer Organization: Group of Electrical Engineering, Communication Engineering, Electronic Engineering, and Information Engineering (ECEI), Tohoku University

    System: Support Program for Young/Female Faculty Members

    Institution: Tohoku University

    2022/12 - 2023/03

  9. タンパク質の迅速高感度検出センサの開発

    薮上 信(代表), TON THAT LOI, 亀井 尚, 小澤 洋平, 岡本 宏史

    Offer Organization: テルモ生命科学振興財団

    System: ２０２２年度 Ⅱ開発助成

    2022/04 - 2023/03

  10. Development of multifunctional composite magnetic micro@nano particles and application to next generation cancer hyperthermia

    TON THAT LOI

    Offer Organization: The Ministry of Education, Culture, Sports, Science and Technology

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists（20K20210）

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2020/04 - 2023/03

  11. Research and development of noise suppression technology using high-resolution measurement and analysis technology for unwanted radio waves Competitive

    Yamaguchi Masahiro et al

    Offer Organization: Ministry of Internal Affairs and Communications

    System: R&D of the following technologies is being conducted in order to expand radio wave resources

    2019 - 2023/03

  12. Research and Development of Multifunctionalization of Magnetic Nanoparticles for Biomedical Applications

    Tonthat Loi

    Offer Organization: Group of Electrical Engineering, Communication Engineering, Electronic Engineering, and Information Engineering (ECEI), Tohoku University

    System: Support Program for Young Faculty Members

    Institution: Tohoku University

    2021/12 - 2022/03

  13. カード型迅速ウイルス検出ＩｏＴセンサモジュールの開発

    薮上 信, 他

    Offer Organization: 国立研究開発法人科学技術振興機構

    Category: A-STEP令和2年度追加公募「トライアウトタイプ」

    Institution: 東北大学

    2021/03 - 2022/03

  14. Development of oral and enteric bacteria sensor for health care Competitive

    Shin Yabukami et al

    Offer Organization: Tohoku University - The Frontier Research Institute for Interdisciplinary Sciences

    System: Interdisciplinary Research Support Program for 2019

    2019/04 - 2022/03

  15. A site to help you realize your ideal self via unobtrusive sensing and "Daily Health Screening", and create a society that improves motivation by way of family bonds Competitive

    Shin Yabukami et al

    Offer Organization: Japan Science and Technology Agency (JST)

    System: Center of Innovation Science and Technology based Radical Innovation and Entrepreneurship Program

    2013/11 - 2022/03

  16. 低コスト迅速高感度ウイルス検出システムの開発と事業化検証

    Shin Yabukami et al

    Offer Organization: 東北大学

    System: 令和2年度第1回東北大学ビジネス･インキュベーション･プログラム（BIP）COVID-19育成

    2020/10 - 2021/09

  17. Development of an integrated magnetic sensor featuring a microwave-assisted nanoferrite-film for high-sensitivity magnetocardiographic measurement Competitive

    Yamaguchi Masahiro et al

    Offer Organization: Japan Society for the Promotion of Science (JSPS)

    System: The Bilateral Joint Research Projects (Japan-India)

    2019/06 - 2021/03

  18. Development of temperature and position detection and heating techniques for hyperthermia using magnetic particles Competitive

    TON THAT LOI

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology

    System: Grant-in-Aid for Scientific Research (Grant-in-Aid for Research Activity Start-up)（19K23597）

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2019/04 - 2021/03

    More details Close

    This project aims to develop a treatment system for magnetic hyperthermia, which is attracting worldwide attention as a next-generation of cancer treatment method. The results of this project are shown the following. (1) We succeeded in developing a simple automatic therapeutic temperature control system using PID. (2) We proposed a simple and rapid a localization method for magnetic particles injected in tumor region by using a figure-8 coil and its spatial linear scanning. (3) To develop high-performance magnetic particles suitable for magnetic hyperthermia, we newly synthesized magnetic iron oxide (Fe3O4) nanoparticles, then evaluated their heating efficiency using a lab-made prototype treatment system and their AC/DC magnetization using SQUID-VSM.

  19. Technology development and commercialization verification for launching magnetic material evaluation service and evaluation equipment manufacturing and sales business Competitive

    Shin Yabukami et al

    Offer Organization: Tohoku University

    System: Business Incubation Program (BIP)

    2019/04 - 2020/03

  20. Development of a high-frequency thin-film magnetic field sensor and biomagnetic measurement at room temperature Competitive

    Shin Yabukami

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology

    System: Grant-in-Aid for Scientific Research (B)

    2016/04 - 2020/03

  21. Development of a microorganism detection system with a sensitivity of 10^2 (CFU / ml) using a highly sensitive thin-film magnetic field sensor Competitive

    Shin Yabukami et al

    Offer Organization: Japan Science and Technology Agency (JST)

    System: Japan Science and Technology Agency A-STEP function verification phase

    2018/12 - 2019/12

  22. Self-regulating hyperthermia using thermosensitive ferromagnetic particles with a low Curie temperature

    Saito Hajime, AKI fumitaka, Tonthat loi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    2016/04/01 - 2019/03/31

    More details Close

    We have developed a method of magnetically induced hyperthermia for malignant tumor using thermosensitive ferromagnetic particles (FMPs) with low Curie temperature (Tc: a transition point at which magnetic materials lose of its magnetic properties, which causes a cessation of current and thus heat production) enough to mediate automatic temperature control. During this research period, we aimed to improve the accuracy of the wireless temperature measurement system, and result was that in the environment at 37 degree temperature the heat generation effect was confirmed to a depth of 5cm, which is sufficient for practical use. A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control.

  23. Research and Development of Wireless Temperature Measurement and Treatment System for Hyperthermia Competitive

    TON THAT LOI

    Offer Organization: Ministry of Education, Culture, Sports, Science and Technology

    System: JSPS Grant-in-Aid for JSPS Fellows（16J09640）

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Akita University

    2016/04 - 2019/03

Show all Show first 5

Teaching Experience 10

  1. Student Experiment B　Tohoku University

  2. Student Experiment B　Tohoku University

  3. Student Experiment B　Tohoku University

  4. Student Experiment B　Tohoku University

  5. 2021 Student Experiment B　Tohoku University

  6. 2020 Engineering Creativity Workshop　Tohoku University

  7. 2020 Student Experiment B　Tohoku University

  8. 2019 Engineering Creativity Workshop　Tohoku University

  9. 2019 Student Experiment B　Tohoku University

  10. 2019 Summer Holiday Children Science Campus　Tohoku University

Show all Show first 5

Social Activities 1

  1. 2019 Summer Holiday Children Science Campus

    2019/08/08 - 2019/08/09