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Takashi Aki

Section

Tohoku University Hospital

Job title

Assistant Professor

Degree

Doctor (Tohoku University)

researchmap

https://researchmap.jp/takashi_aki

J-GLOBAL ID

202001016269553910

e-Rad No.

10881956

Research Interests 4

マーカーレス動作解析（Pose Estimation / MoCap）
ジュニアアスリートのスポーツ傷害調査・予防
運動器超音波診療/研究
変形性膝関節症の早期治療

Research Areas 3

Life sciences / Rehabilitation science /
Life sciences / Sports science /
Life sciences / Orthopedics /

Papers 32

Preoperative coronal alignment and tibial implant positioning affect condylar lift‐off in BCS‐TKA

Kento Harada, Masayuki Kamimura, Yu Mori, Takashi Aki, Shunsuke Utsumi, Tomokazu Tanita, Toshiya Uehara, Toshimi Aizawa

Journal of Experimental Orthopaedics　12　(4)　2025/10
Publisher: Wiley
DOI： 10.1002/jeo2.70609 　

ISSN： 2197-1153

eISSN： 2197-1153

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Abstract Purpose Condylar lift‐off is the phenomenon in which the femoral component lifts off from the polyethylene insert. In some cases, the mechanical hip–knee–ankle angle (mHKAA) appears more varus than the arithmetic hip–knee–ankle angle (aHKAA) in a standing position, which is thought to be related to lift‐off. This study analyzed factors influencing the difference between postoperative aHKAA and mHKAA in bi‐cruciate‐stabilized total knee arthroplasty (BCS‐TKA). Methods This study included 100 knees that underwent BCS‐TKA. Full‐length standing radiographs of both lower extremities were obtained preoperatively and 1‐year postoperatively. The mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), and mHKAA were measured and aHKAA (mMPTA−mLDFA) was calculated. The difference between postoperative aHKAA (post‐aHKAA) and post‐mHKAA was defined as post‐ΔHKAA (post‐mHKAA−post‐aHKAA). Correlations between post‐ΔHKAA and the measured parameters were analyzed, and multivariable linear regression analyses were performed to identify independent predictors of post‐ΔHKAA. Results Post‐ΔHKAA was significantly correlated with preoperative mLDFA (pre‐mLDFA, r = −0.30, p < 0.001), pre‐aHKAA ( r = 0.22, p = 0.02), pre‐mHKAA ( r = 0.21, p = 0.03) and post‐mMPTA ( r = −0.29, p = 0.004). Multivariable linear regression analyses revealed that pre‐mLDFA ( β = −0.20, p = 0.02) and post‐mMPTA ( β = −0.32, p = 0.01) were independently associated with post‐ΔHKAA. These results indicate that performing TKA in cases with severe femoral varus alignment and placing the tibial implant in valgus relative to the original joint surface leads to increased postoperative coronal varus alignment in the standing position. Conclusion In BCS‐type TKA, postoperative condylar lift‐off in standing positions is more likely to occur in cases with severe preoperative femoral varus alignment or with valgus tibial implant placement. Level of Evidence Level Ⅳ.
Proposal of a new indicator of hip compensation for spinopelvic-hip mismatch: a retrospective study in Japan. International-journal

Ryo Fujita, Kohei Takahashi, Ko Hashimoto, Kazuyoshi Baba, Kenichiro Yahata, Takahiro Onoki, Takashi Aki, Keisuke Ishikawa, Toshimi Aizawa

Asian spine journal　2025/08/11

DOI： 10.31616/asj.2024.0475 　

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STUDY DESIGN: retrospective study. PURPOSE: This study aimed to develop an indicator of the compensatory capacity of hip joints in response to spinopelvic mismatch using standard radiographs. OVERVIEW OF LITERATURE: EOS imaging has enabled detailed analysis of hip and lower extremity compensation in sagittal malalignment. However, its high cost and limited availability hinder widespread clinical use. Currently, there are no established indicators to assess hip compensation for spinopelvic mismatch using standard radiographs. METHODS: A total of 209 patients with osteoporosis and 54 with adult spinal deformities were included. Patients were divided into two groups based on pelvic incidence-lumbar lordosis (PI-LL): <20° and ≥20° groups. The sagittal vertical axis (SVA), thoracic kyphosis, PI, pelvic tilt (PT), LL, sacral slope, and pelvic femoral angle (PFA) were measured. Health-related quality of life (HRQOL) was assessed in 86 patients using the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ). A new index, PFA-(PI-LL), was defined as spinopelvic-hip mismatch. Correlation coefficients were calculated for each radiographic parameter, and the coefficient of determination (R2) for the relationship of each parameter with SVA was evaluated in both groups. The correlations between SVA, PT, PI-LL, PFA-(PI-LL), and JOABPEQ domain scores were also analyzed. RESULTS: PI-LL correlated with PFA in the PI-LL <20° group (r=0.56, p<0.001) but not in the PI-LL ≥20° group. Among all parameters, PFA-(PI-LL) demonstrated the strongest association with SVA, indicating its superior ability to explain variations in sagittal alignment in both groups and across all patients (all patients, R2=0.77). Significant correlations were observed between the radiographic parameters and JOABPEQ scores across all domains. CONCLUSIONS: PFA-(PI-LL), which represented spinopelvic-hip mismatch, was a reliable indicator of hip compensatory function in terms of anterior trunk inclination and HRQOL.
Total Knee Arthroplasty in Patients With Ankle Osteoarthritis Affects Contralateral Ankle Alignment and Postoperative Outcome of Total Knee Arthroplasty. International-journal

Tomoki Koyama, Yu Mori, Shunsuke Utsumi, Kento Harada, Kentaro Ito, Hidetatsu Tanaka, Takashi Aki, Hideaki Nagamoto, Masayuki Kamimura, Toshimi Aizawa

Foot & ankle international　10711007241283783-10711007241283783　2024/11/06

DOI： 10.1177/10711007241283783 　

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BACKGROUND: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles. METHODS: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side. Additionally, we examined the impact of ankle OA on postoperative clinical scores, the Knee injury and Osteoarthritis Outcome Score, following TKA. RESULTS: Based on the classification, ankle OA stage 2 or higher was present in 13 cases on the surgical side and 13 cases on the contralateral side. On the surgical side, mHKA changed from 12.2 to 1.8 degrees varus (P < .001) and TTA from 1.7 to 1.0 degrees varus (P = .002). On the contralateral side, mHKA changed from 4.0 to 5.4 degrees varus (P = .04), and TTA from 2.7 to 3.0 degrees varus (P < .001). In ankle OA stage 2 or higher patients, contralateral TTA changed from 5.2 to 6.5 degrees varus (P < .001) and unchanged in stage 1 patients. Ankle OA stage 2 or higher patients had worse ADL outcomes than stage 1 patients (score: 67.2 and 78.3, respectively, P = .03). CONCLUSION: This study suggests an apparent interrelationship between knee and ankle OA and the potential negative influence of TKA on ankle OA.
Impact of Aging and Knee Osteoarthritis on Lower Limb Alignment and CPAK Classification: Gender Differences in a Japanese Cohort

Kento Harada, Yu Mori, Masayuki Kamimura, Takashi Aki, Tomoki Koyama, Toshimi Aizawa

Journal of Clinical Medicine　2024/10/19

DOI： 10.3390/jcm13206250 　
Harmony between spinopelvic mismatch and sagittal hip alignment contributes to upright standing in females: a cross-sectional study. International-journal

Kazuyoshi Baba, Kohei Takahashi, Ko Hashimoto, Takahiro Onoki, Takashi Aki, Ryo Fujita, Keisuke Ishikawa, Toshimi Aizawa

Journal of spine surgery (Hong Kong)　10　(2)　244-254　2024/06/21

DOI： 10.21037/jss-23-145 　

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BACKGROUND: In upright standing, spinopelvic mismatch is compensated by hip extension. However, few studies have investigated the reciprocal relationship between the sagittal alignment of the hip joints and spinopelvic mismatch during upright standing in humans. Our study aims to investigate (I) the relationship between spinopelvic mismatch and hip extension and (II) whether insufficient hip extension against spinopelvic mismatch, i.e., pelvic incidence (PI)-lumbar lordosis (LL), affects trunk inclination in upright standing. METHODS: This study was a retrospective cross-sectional study. We included 398 consecutive female patients treated for osteoporosis at our outpatient department between November 2017 and June 2022. Patients with any of the following were excluded from the study: (I) those whose plain whole-spine radiographs did not cover the femurs, (II) those with fractures in the vertebrae or lower extremities, (III) those with a history of surgery of the spine or of the lower extremities, (IV) those with scoliosis with a Cobb angle ≥10° in the anteroposterior radiograph, and (V) those with transitional vertebrae. Sixty-two patients were divided into normal and malalignment groups based on their sagittal spinal alignment. The patients underwent plain whole-spine radiography as a routine examination. A linear approximation between the pelvic femoral angle (PFA), representing hip extension, and PI-LL was obtained in both groups. The optimal PFA of each patient was obtained by substituting the PI-LL into the linear approximation of the normal group. The difference between the optimal and measured PFA was defined as the ΔPFA for each patient. The correlation between the ΔPFA and sagittal vertical axis (SVA) was evaluated in both groups. RESULTS: The PFA and PI-LL were correlated in both groups. The malalignment group had a significantly greater ΔPFA than the normal group. ΔPFA was correlated with SVA only in the malalignment group. CONCLUSIONS: The magnitude of the ΔPFA indicated insufficient hip extension to compensate for the spinopelvic mismatch during upright standing.
Differences in kinematic parameters during gait between the patients with knee osteoarthritis and healthy controls using an insole with a single inertial measurement unit: A case-control study

Haruki Yaguchi, Keita Honda, Yusuke Sekiguchi, Chenhui Huang, Kenichiro Fukushi, Zhenwei Wang, Kentaro Nakahara, Masayuki Kamimura, Takashi Aki, Ken Ogura, Shin-Ichi Izumi

Clinical Biomechanics　106191-106191　2024/01
Publisher: Elsevier BV
DOI： 10.1016/j.clinbiomech.2024.106191 　

ISSN： 0268-0033
脊椎後彎症患者の変形矯正術前後で股関節の運動学的特性はどう変化するか? 三次元動作解析装置を用いた歩行解析による検討

藤田涼, 高橋康平, 関口雄介, 鎌田久美, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(8)　S1841-S1841　2023/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway

Yu Mori, Kazuko Ueno, Daisuke Chiba, Ko Hashimoto, Yosuke Kawai, Kazuyoshi Baba, Hidetatsu Tanaka, Takashi Aki, Masanori Ogasawara, Naoto Shibasaki, Katsushi Tokunaga, Toshimi Aizawa, Masao Nagasaki

International Journal of Molecular Sciences　24　(5)　5019-5019　2023/03/06
Publisher: MDPI AG
DOI： 10.3390/ijms24055019 　

eISSN： 1422-0067

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This study examined the association between developmental dysplasia of the hip (DDH) and disease-associated loci in a Japanese cohort. A genome-wide association study (GWAS) of 238 Japanese patients with DDH and 2044 healthy individuals was performed. As a replicate, GWAS was also conducted on the UK Biobank data with 3315 cases and matched 74,038 controls. Gene set enrichment analyses (GSEAs) of both the genetics and transcriptome of DDH were performed. Transcriptome analysis of cartilage specimens from DDH-associated osteoarthritis and femoral neck fractures was performed as a control. Most of the lead variants were very low-frequency ones in the UK, and variants in the Japanese GWAS could not be replicated with the UK GWAS. We assigned DDH-related candidate variants to 42 and 81 genes from the Japanese and UK GWASs, respectively, using functional mapping and annotation. GSEA of gene ontology, disease ontology, and canonical pathways identified the most enriched pathway to be the ferroptosis signaling pathway, both in the Japanese gene set as well as the Japanese and UK merged set. Transcriptome GSEA also identified significant downregulation of genes in the ferroptosis signaling pathway. Thus, the ferroptosis signaling pathway may be associated with the pathogenic mechanism of DDH.
脊椎後彎症患者の立位静止時および歩行時の体幹前傾と股関節肢位の関係 3D動作解析装置とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(3)　S794-S794　2023/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Two-stage revision knee arthroplasty for metallosis in a patient with rheumatoid arthritis: A case report

Tomoki Koyama, Yu Mori, Masayuki Kamimura, Takashi Aki, Takuya Izumiyama, Naoko Mori, Daisuke Chiba, Ko Hashimoto, Nobuyuki Yamamoto, Toshimi Aizawa

SAGE Open Medical Case Reports　2023/01

DOI： 10.1177/2050313X231177752 　
足関節捻挫の既往と後足部アライメントの関連

佐藤宏陽, 永元英明, 秋貴史, 矢口春木, 高橋博之

日本臨床スポーツ医学会誌　30　(4)　S252-S252　2022/10
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
20代プロバレーボール選手に生じた内側半月板後根損傷の1例

阿部高久, 秋貴史, 川上純, 永元英明, 佐藤宏陽, 矢口春木

日本臨床スポーツ医学会誌　30　(4)　S308-S308　2022/10
Publisher: (一社)日本臨床スポーツ医学会
ISSN： 1346-4159
外反型変形性膝関節症に対する遠位大腿骨骨切り術3例4膝の治療成績

有野敦司, 秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 相澤俊峰

東北膝関節研究会会誌　30　27-31　2022/07
Publisher: 東北膝関節研究会
ISSN： 0917-5164

eISSN： 2433-5614

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症例1は46歳男で、30歳頃から右膝の外反変形と疼痛を自覚し、徐々に左膝痛も自覚するようになった。今回、両膝の疼痛が増悪し、手術目的で当科に紹介された。単純X線で両膝ともKL分類grade 4の外反型OAを呈しており、%MAは105%/70%、FTAは160°/168°、mLDFAは81°/82°であった。手術は初めに右膝へDFOを行い、1年後に左膝へDFOを施行した。術後アライメントの矯正目標を%MA 50%とし、矯正角が右13°、左8°のMedial biplane closed wedge osteotomyを行った。右は術後4.5ヵ月で骨癒合が得られ、左は術後9.5ヵ月で骨癒合が得られた。最終観察時の%MAは33%/40%、FTAは180°/178°、mLDFAは92°/91°であった。症例2は69歳女で、53歳時から左膝痛を自覚し、近医で保存療法を受けていたが痛みは改善しないため手術目的で当科に紹介された。KL分類grade 4の外反型OAを認め、%MAは104%、FTAは156°、mLDFAは74°であった。矯正角度15°としてDFOを施行し、術後3ヵ月で骨癒合が得られ、最終観察時の%MAは38%、FTAは178°、mLDFAは89°であった。症例3は60歳女で、56歳時から右膝痛を自覚し、徐々に増悪したため手術目的で当科に紹介された。KL分類grade 3の外反型OAを認め、%MAは61%、FTAは168°、mLDFAは83°であった。矯正角度8°としてDFOを施行し、最終観察時の%MAは25%、FTAは180°、mLDFAは91°であった。
「若年に見られる膝外傷後変形性膝関節症のマネジメント」 ACL再建術後に生じるOA変化の実態 KOACADを用いた定量評価

秋貴史, 上村雅之, 伊東健太郎, 阿部高久, 古口昌志, 佐藤宏陽, 藤盛理子, 井樋栄二, 相澤俊峰, 曽木靖仁

東北整形災害外科学会雑誌　65　(1)　173-174　2022/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎矢状面アライメントと股関節矢状面アライメントの関係

馬場一慈, 高橋康平, 石川圭佑, 藤田涼, 秋貴史, 大野木孝嘉, 橋本功, 関口雄介, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(2)　S193-S193　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
脊椎後彎症患者の歩行時と立位時の股関節肢位三次元動作解析装置を用いた歩行解析とX線計測による検討

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 大野木孝嘉, 馬場一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　96　(3)　S754-S754　2022/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Morphological and Morphometrical Analyses of Fracture-Healing Sites of an Atypical Femoral Fracture in Patients with and without Long-Term Bisphosphonate Treatment for Osteoporosis: A Report of Two Cases.

Takashi Aki, Ko Hashimoto, Hiroaki Uozumi, Masahiro Saito, Ko Sugawara, Manabu Suzuki, Soshi Hamada, Akemi Ito, Eiji Itoi

The Tohoku journal of experimental medicine　253　(4)　261-267　2021/04

DOI： 10.1620/tjem.253.261 　

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Bisphosphonates have been the first drug of choice for osteoporosis in the recent years because of their known ability to suppress osteoclast activity. The adverse effect of long-term bisphosphonate administration in the fracture-healing process is controversial. The aim of our study was to observe not only morphology but also morphometry of the fracture site of atypical femoral fracture with and without long-term bisphosphonate administration, in a case study of two difficult-to-obtain human samples. The patients with insufficient healing of atypical femoral fracture were treated with valgus wedge osteotomy. Histomorphometrical analysis was performed in bone samples of fracture sites harvested during osteotomy. The thickness of the femoral cortex was measured in the fracture site and the adjacent, non-fracture site. A comparative analysis of the content of hypertrophic osteoclasts in fracture sites, shape and size of osteons, mass, and ratio of the woven bone to the total bone mass was performed, comparing bisphosphonate-treated and untreated samples. In bisphosphonate-treated samples, we observed femoral cortex thickening at the fracture site; the appearance of hypertrophic osteoclasts; decreased bone resorption surface, decreased osteoclast numbers on the bone resorption surface, and increased ratio of multinuclear osteoclasts; osteons were misshapen and thin; and the mass and ratio of the woven bone to the total bone mass were higher. This study demonstrated that long-term bisphosphonate administration can alter the morphological features of the fracture site compared to its physiological state.
当院初診患者における若年性変形性膝関節症の実態

曽木靖仁, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

東北膝関節研究会会誌　27　29-32　2018/07
Publisher: 東北膝関節研究会
ISSN： 0917-5164

eISSN： 2433-5614

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当大学病院整形外科膝関節専門外来の初診患者1774人を対象に、49歳以下の変形性膝関節症(膝OA)の原因(一次性または二次性)、高度肥満患者(BMI≧40)の割合、治療方法を調査した。その結果、49歳以下の患者は776人で、うち32人(4.1%)が膝OAと診断された。32人中、一次性膝OAと二次性膝OAは16人ずつであった。高度肥満患者は一次性膝OAで16人中8人(50%)、二次性膝OAで16人中3人(19%)であった。二次性膝OAの原疾患は、十字靱帯損傷後6人、半月板損傷後1人、骨折後4人、骨系統疾患2人、化膿性膝関節炎後1人、反復性膝蓋骨脱臼後2人であった。手術は11人に行われ、うち10人は骨切り術であった。残りの1人には、術前に関節変形と可動域制限が大きかったため人工膝関節全置換術が行われた。以上、若年性の一次性膝OAの主な原因は高度肥満で、二次性膝OAの主な原因は靱帯損傷であると考えられた。
膝前十字靱帯再建術後の関節症変化

小笠原将教, 高橋敦, 上村雅之, 秋貴史, 國井知典, 板谷信行, 曽木靖仁, 井樋栄二

東北膝関節研究会会誌　27　33-37　2018/07
Publisher: 東北膝関節研究会
ISSN： 0917-5164

eISSN： 2433-5614

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膝前十字靱帯再建術を行った140例143膝を対象に、年齢、性別、BMI、初回受傷〜手術の期間、半月板切除、手術時ICRS分類grade 2以上の軟骨損傷の有無を調査した。手術時に既にKellgren-Lawrence(KL)分類grade 2以上であった群(変形性膝関節症:OAあり群)とgrade 0または1であった群(OAなし群)の比較、術前にKL分類grade 0または1であったが術後にgrade 2以上となった群(OA出現群)とgrade 1以下のままであった群(OA非出現群)の比較を行った。その結果、143膝中8膝にOAを認めた。手術時に既にOAを合併していたのは4膝(いずれも女性)で、初回受傷から手術までの期間が9〜23年と長かった。また、これら4膝は手術時にOAを合併していなかった139膝に比べ、有意に年齢が高く、再々建例が多かった。術後にOAを生じたのは4膝で、うち3膝は1年以内の出現であった。これら4膝は術後にOAが出現しなかった139膝に比べ、有意にBMIが高かった。また、4膝のうち2膝は手術時に半月板の処置を要していた。
ACL損傷膝に生じる変化 3D MRIによる検討

高橋敦, 上村雅之, 國井知典, 秋貴史, 柏葉光宏, 小笠原将教, 曽木靖仁, 井樋栄二

JOSKAS　43　(4)　326-326　2018/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
KOACADにより評価したACL再建術後の内側関節裂隙狭小化と関連する因子の検討

曽木靖仁, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

JOSKAS　43　(4)　684-684　2018/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
A whole-genome transcriptome analysis of articular chondrocytes in secondary osteoarthritis of the hip. International-journal

Takashi Aki, Ko Hashimoto, Masanori Ogasawara, Eiji Itoi

PloS one　13　(6)　e0199734　2018

DOI： 10.1371/journal.pone.0199734 　

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OBJECTIVE: To date, exhaustive gene expression analyses of chondrocytes in hip osteoarthritis (OA) have yielded specific gene expression patterns. No study has reported on the exhaustive transcriptome of secondary hip OA based on acetabular dysplasia in a Japanese population, while previous reports have focused on primary or idiopathic hip OA in Caucasian populations. This study aims to search for specific gene expression patterns of secondary hip OA chondrocytes by transcriptome analysis. DESIGN: Human articular cartilage was obtained from femoral heads following hemiarthroplasty for femoral neck fracture (N = 8; non-OA) and total hip arthroplasty for secondary hip OA (N = 12). Total RNA was extracted from the articular cartilage and submitted for microarray analysis. The obtained data were used to perform gene expression analysis, GO enrichment analysis and pathway analysis and were compared with data from primary hip OA in Caucasian populations in the literature. RESULTS: We identified 888 upregulated (fold change: FC ≥ 2) and 732 downregulated (FC ≤ 0.5) genes in hip OA versus non-OA chondrocytes, respectively. Only 10% of upregulated genes were common between the secondary and primary OA. The newly found genes prominently overexpressed in the secondary hip OA chondrocytes were DPT, IGFBP7, and KLF2. Pathway analysis revealed extracellular matrix (ECM)-receptor interaction as an OA-related pathway, which was similar to previous reports in primary hip OA. CONCLUSIONS: This is the first study to report the genome-wide transcriptome of secondary hip OA chondrocytes and demonstrates new potential OA-related genes. Gene expression patterns were different between secondary and primary hip OA, although the results of pathway and functional analysis were similar.
Femoral footprint of the popliteus tendon may be at the risk of damage during total knee arthroplasty. International-journal

Takashi Aki, Takehiko Sugita, Atsushi Takahashi, Toshimi Aizawa, Masayuki Kamimura, Akira Sasaki, Naohisa Miyatake, Eiji Itoi

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA　25　(12)　3718-3722　2017/12

DOI： 10.1007/s00167-016-4177-z 　

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PURPOSE: The present study focused on the prevalence of incidental excision of the femoral footprint of the popliteus tendon during total knee arthroplasty and its associated risk factors. METHODS: A total of 275 knee arthroplasties were performed for 226 patients with varus knee osteoarthritis. The status of the femoral footprint of the popliteus tendon was intraoperatively evaluated and classified into three groups (preserved, partially excised, and completely excised), and the prevalence of the excision was identified. Femoral component size, the thickness of the resected distal femoral condyle, and preoperative patient demographic data were compared for the three groups. Ordinal logistic regression analysis was performed to reveal risk factors associated with the excision. RESULTS: The femoral footprint of the popliteus tendon was preserved in 132 knees (48.0 %), partially excised in 94 knees (34.2 %) and completely excised in 49 knees (17.8 %). The ordinal logistic regression analysis revealed thicker resection of the distal femoral condyle (p < 0.0001) and shorter body height (p = 0.0266) to be the independent risk factors for the excision. CONCLUSIONS: The incidental partial or complete excision of the femoral footprint of the popliteus tendon was identified in approximately half of the evaluated knees. Thicker resection of the distal femoral condyle and shorter body height were the most significant risk factors for the excision. LEVEL OF EVIDENCE: Case-control study, Level III.
日本人二次性変形性股関節症の関節軟骨細胞における遺伝子発現の網羅的解析欧米人データとの比較

秋貴史, 橋本功, 小笠原将教, 高橋敦, 井樋栄二

日本整形外科学会雑誌　91　(8)　S1601-S1601　2017/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
ミトコンドリア病治療薬MA-5はヒト培養軟骨細胞において軟骨基質破壊関連遺伝子の発現を抑制する

小笠原将教, 橋本功, 秋貴史, 高橋敦, 井樋栄二, 阿部高明

日本整形外科学会雑誌　91　(8)　S1755-S1755　2017/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
ヒト関節軟骨におけるMMP13、IL1B遺伝子発現に関わる転写因子の網羅的解析

秋貴史, 橋本功, 小笠原将教, 高橋敦, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1472-S1472　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
日本人の変形性股関節症における遺伝子発現パターンの網羅的解析

小笠原将教, 橋本功, 秋貴史, 高橋敦, 井樋栄二

日本整形外科学会雑誌　90　(8)　S1472-S1472　2016/08
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
Potential risk of excising the femoral insertion of the popliteus tendon during primary total knee arthroplasty: a biometric study.

Atsushi Takahashi, Takehiko Sugita, Toshimi Aizawa, Daisuke Chiba, Masayuki Kamimura, Takashi Aki, Eiji Itoi

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association　20　(6)　1030-5　2015/11

DOI： 10.1007/s00776-015-0773-x 　

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BACKGROUND: During total knee arthroplasty (TKA), excision of the popliteus tendon leads to extensive static gaps and reduced mobility. The purpose of this study was to determine the positional relationship between the femoral insertion of the popliteus tendon and the bone cutting lines of various TKA systems. METHODS: This study included 21 cadaveric right femurs presenting no macroscopic deformity. The lateral image of the femur and the template of the femoral component were overlaid to determine the preservation/excision of the popliteus tendon insertion. TKA systems used were Genesis II, NexGen, low contact stress (LCS), PFC Σ, Scorpio, and Vanguard. The knees in which the insertion was preserved in all implants or excised in at least one implant were classified into intact or the high-risk groups, respectively. RESULTS: The popliteus tendon was preserved in all specimens with the LCS system. In contrast, the popliteus tendon insertion was excised in ≥1/3 of the specimens with the other systems. The anteroposterior diameter was significantly larger in the intact group than that in the high-risk group (58.1 ± 4.5 mm vs. 53.7 ± 2.7 mm; p = 0.018). The high-risk group included more knees from female cadavers than the intact group (70 vs. 9 %; p = 0.008). CONCLUSION: During primary TKA, the femoral insertion of the popliteus tendon could be inevitably excised, regardless of technical problems. We demonstrate that the unique design of the LCS system preserves the popliteus tendon insertion. In addition, small knees and females may be risk factors for excision of the insertion.
Effect of medial tibial torsion on the sagittal alignment of lower legs in patients with medial knee osteoarthritis. International-journal

Atsushi Takahashi, Toshimi Aizawa, Takashi Aki, Mitsuhiro Kashiwaba, Masayuki Kamimura, Shin Hitachi, Eiji Itoi

Surgical and radiologic anatomy : SRA　35　(3)　205-10　2013/04

DOI： 10.1007/s00276-012-1011-2 　

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PURPOSE: The fibular axis (FA) and anterior tibial cortex (ATC) are good determinants of the sagittal mechanical axis (MA) of lower legs during total knee arthroplasty (TKA).When compared with healthy subjects, a significant medial tibial torsion has been reported in patients with medial knee osteoarthritis; this should affect the alignment of lower legs. The purpose of this study was to clarify the effect of the medial torsion on relationship between sagittal MA and intraoperative references (FA and ATC). METHODS: Fifty knees of 50 patients with medial knee osteoarthritis who underwent primary TKA were included in this study. Using preoperative computed tomographic data, the tibial torsion angle was measured in the axial plane. The angle between FA and MA, and the angle between ATC and MA were also measured in the sagittal plane. RESULTS: The tibial torsion angle was 7.9° ± 7.2° (range -11.3° to -24.3°). The angle between MA and FA was -1.8° ± 0.8° (range -0.1° to -4.3°), and the angle between MA and ATC was 4.6° ± 0.5° (range 3.1° to 5.5°). The population variance was significantly larger for the angle between MA and FA than that between MA and ATC (P = 0.0160). There was a significant positive correlation between the tibial torsion angle and the angle between MA and FA (R (2) = 0.5111, P < 0.0001). CONCLUSION: The angle between FA and MA in the sagittal plane increased in patients with large medial tibial torsion.
大腿骨内側顆骨壊死症の内側半月板断裂形態

小笠原将教, 梅原寿太郎, 佐藤心一, 後藤伸一, 中村聡, 田中秀達, 秋貴史

東北整形災害外科学会雑誌　55　(1)　181-181　2011/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
当科での下肢手術後におけるフォンダパリヌクス(FPX)の使用経験

小笠原将教, 梅原寿太郎, 佐藤心一, 後藤伸一, 中村聡, 田中秀達, 秋貴史

秋田県農村医学会雑誌　56　(1)　37-37　2010/07
Publisher: (一財)秋田県農村医学会
ISSN： 0002-368X

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Misc. 26

PFA-(PI-LL), as a new index called spinopelvic-hip mismatch, can predict disability from low back pain

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 森優, 橋本功, 相澤俊峰

Journal of Spine Research (Web)　16　(3)　2025

ISSN： 2435-1563
ヒトの直立には脊椎骨盤と股関節の協調が必要である

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 八幡健一郎, 橋本功, 相澤俊峰

日本整形外科学会雑誌　98　(2)　2024

ISSN： 0021-5325
腰椎後弯症患者の立位保持には十分な股関節伸展が必要である

藤田涼, 高橋康平, 石川圭佑, 大野木孝嘉, 秋貴史, 馬場一慈, 菅野晴夫, 橋本功, 小澤浩司, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023

ISSN： 0021-5325
脊椎-骨盤ミスマッチに対する股関節代償機能の検討-PI-LLと股関節伸展の関連-

馬場一慈, 高橋康平, 秋貴史, 石川圭佑, 藤田涼, 大野木孝嘉, 橋本功, 相澤俊峰

日本整形外科学会雑誌　97　(3)　2023

ISSN： 0021-5325
サルコペニアと後弯症:後弯症患者の歩行速度に関与する因子-三次元動作解析装置を用いた歩行解析とレントゲン計測による検討-

石川圭佑, 高橋康平, 関口雄介, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

日本骨粗鬆症学会雑誌　9　(Suppl.1 (CD-ROM))　2023

ISSN： 2189-8383
Hip and knee position in patients with spinal kyphosis: Gait analysis with three-dimensional motion capture system

石川圭佑, 高橋康平, 関口雄介, 鎌田久美, 藤田涼, 大野木孝嘉, 馬塲一慈, 秋貴史, 橋本功, 出江紳一, 小澤浩司, 相澤俊峰

Journal of Spine Research (Web)　13　(3)　2022

ISSN： 2435-1563
小学生野球選手における上腕骨小頭離断性骨軟骨炎の有病率と競技レベルとの関係

黒川大介, 石川博明, 松岡俊介, 山田祥康, 藤盛理子, 矢口春木, 品川清嗣, 秋貴史, 永元英明, 村木孝行, 高橋博之

日本整形外科スポーツ医学会雑誌　39　(4)　649-649　2019/08
Publisher: (一社)日本整形外科スポーツ医学会
ISSN： 1340-8577

eISSN： 2435-5828
ACL損傷膝における前外側構成体の損傷頻度3D‐MRI

國井知典, 高橋敦, 柏葉光宏, 上村雅之, 猪川訓志, 秋貴史, 板谷信行, 小笠原将教, 伊東健太郎

JOSKAS　43　(4)　503-503　2018/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
ACL損傷膝における前外側構成体の損傷頻度3D-MRI

國井知典, 高橋敦, 柏葉光宏, 上村雅之, 猪川訓志, 秋貴史, 板谷信行, 小笠原将教, 伊東健太郎

JOSKAS　43　(4)　503-503　2018/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
KOACADにより評価したACL再建術後の内側関節裂隙狭小化と関連する因子の検討

曽木靖仁, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

JOSKAS　43　(4)　684-684　2018/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
ACL再建術の長期成績と二次性関節症 ACL再建術後の関節症性変化

高橋敦, 小笠原将教, 上村雅之, 秋貴史, 板谷信行, 國井知典, 井樋栄二

日本関節病学会誌　36　(3)　339-339　2017/10
Publisher: (一社)日本関節病学会
ISSN： 1883-2873
診断・治療に難渋した膝症例外傷後の脛骨内反変形と変形性膝関節症により高度内反膝を呈した1例

秋貴史, 高橋敦, 上村雅之, 藤澤博一, 板谷信行, 國井知典, 井樋栄二

東北整形災害外科学会雑誌　60　(1)　187-187　2017/06
Publisher: 東北整形災害外科学会
ISSN： 1348-8694
Open wedge HTOの回旋アライメント変化 CT fusion画像による解析

秋貴史, 高橋敦, 上村雅之, 藤澤博一, 板谷信行, 小笠原将教, 國井知典, 柏葉光宏, 井樋栄二

JOSKAS　42　(4)　320-320　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
日本人早期膝OAの前向き実態調査

高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

JOSKAS　42　(4)　455-455　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
ACL再断裂症例の脛骨後傾

阿部高久, 高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 井樋栄二

JOSKAS　42　(4)　640-640　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
人工膝関節全置換術後における床からの立ち上がり動作および所要時間の解析

上村雅之, 高橋敦, 秋貴史, 板谷信行, 井樋栄二

JOSKAS　42　(4)　653-653　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
TKA設置精度の変遷から分かったこと 8年間の3D-CTによる設置精度評価

高橋敦, 上村雅之, 秋貴史, 板谷信行, 小笠原将教, 國井知典, 井樋栄二

JOSKAS　42　(4)　655-655　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
ACL損傷膝における前外側構成体の損傷頻度 3D-MRIを用いて

國井知典, 高橋敦, 柏葉光宏, 伊東健太郎, 猪川訓志, 秋貴史, 上村雅之, 板谷信行, 小笠原将教, 井樋栄二

JOSKAS　42　(4)　706-706　2017/05
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
人工膝関節全置換術後の床からの立ち上がり動作の解析

上村雅之, 高橋敦, 藤澤博一, 板谷信行, 秋貴史, 井樋栄二

日本整形外科学会雑誌　91　(3)　S1006-S1006　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
TKAインプラント回旋設置とfemorotibial mismatchの関係

秋貴史, 高橋敦, 上村雅之, 藤澤博一, 板谷信行, 國井知典, 井樋栄二

日本整形外科学会雑誌　91　(3)　S1018-S1018　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
TKA設置精度の変遷から分かったこと 8年間の3D-CTによる設置精度評価

高橋敦, 上村雅之, 藤澤博一, 秋貴史, 板谷信行, 井樋栄二, 大沼正宏, 柏葉光宏

日本整形外科学会雑誌　91　(3)　S1019-S1019　2017/03
Publisher: (公社)日本整形外科学会
ISSN： 0021-5325
人工膝関節全置換術後における床からの立ち上がり動作の解析

上村雅之, 高橋敦, 藤澤博一, 板谷信行, 秋貴史, 井樋栄二

JOSKAS　41　(4)　285-285　2016/07
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
中高年の膝痛は画像に写るか?

高橋敦, 上村雅之, 藤澤博一, 秋貴史, 板谷信行, 國井知典, 井樋栄二

JOSKAS　41　(4)　357-357　2016/07
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
TKAインプラント回旋設置とfemorotibial mismatchの関係

秋貴史, 高橋敦, 上村雅之, 藤澤博一, 板谷信行, 柏葉光宏, 國井知典, 井樋栄二

JOSKAS　41　(4)　404-404　2016/07
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
内側半月板後角損傷後SONK発生とOA進行に関する前向き調査

高橋敦, 梅原寿太郎, 上村雅之, 藤澤博一, 秋貴史, 板谷信行, 魚住弘明, 井樋栄二

JOSKAS　40　(4)　558-558　2015/06
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842
膝窩筋腱大腿骨付着部とTKA骨切り線の関係に関する解剖学的研究

高橋敦, 杉田健彦, 柏葉光宏, 千葉大介, 秋貴史

JOSKAS　36　(4)　181-181　2011/06
Publisher: (一社)日本関節鏡・膝・スポーツ整形外科学会
ISSN： 1884-8842

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Research Projects 2

Relationship between disease-specific skeletal muscle function based on the 3-D assessment of lower limb and gait characteristics in cases with osteoarthritis

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2023/04/01 - 2026/03/31
Elucidating the function of promoter DNA methylation status on IL1B gene regulation in human articular chondrocytes

Hashimoto Ko, AKI Takashi, OGASAWARA Masanori

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2014/04/01 - 2016/03/31

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The gene expression of chondrocytes was exhaustively analyzed (24,460 genes), and compared between osteoarthritic (OA) and non-OA human femoral heads. In contrast to our previous study conducted with caucasian samples, the expression level of IL1B was not upregulated in Japanese OA chondrocytes. In addition to the previously reported 3 OA-related genes in Japanese population, our research newly revealed 19 potential OA-related genes. Moreover, the gene expression patterns of OA chondrocytes were assumed to be different between Japanese and caucasian populations. The transcription factors, FOS, LEF1 and CREB3L4 were found to be potential transcriptional regulators of MMP13, a key factor of OA pathogenesis, via DNA methylation of its promoter.