TOHOKU UNIVERSITY Researchers - Hiroyasu Kanetaka

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Hiroyasu Kanetaka

Section

Graduate School of Dentistry

Job title

Professor

Degree

博士（歯学）（東北大学）

researchmap

https://researchmap.jp/h.kanetaka

J-GLOBAL ID

200901065912852809

Education 2

Tohoku University　Graduate School, Division of Dental Research　歯学臨床系

- 1997/03
Tohoku University　Faculty of Dentistry　歯学

- 1993/03

Research Interests 2

歯科医工学
歯科矯正学

Research Areas 1

Life sciences / Regenerative dentistry and dental engineering /

Awards 11

Poster Presentation Award

2018/10　30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics30)　Magnetic Property and Heat-Generating Ability of Iron Nitrides.
Oral Presentation Award

2018/10　30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics30)　Cytotoxicity of Antibacterial Metal-Doped Raw Silk Fabric.
優秀ポスター賞

2018/08　日本バイオマテリアル学会東北ブロック　微量金属元素ドープチタンのアパタイト形成能と抗菌性
平成29年度優秀論文賞

2018/05　日本口蓋裂学会　口唇裂患者の三次元顔面形態、咬合関係および口腔機能の相互の関連性について
Poster competition First place

2018/04　American Academy of Cosmetic Dentistry　Comparative evaluation of composite resin restorations fabricated from CAD/3D printing and CAD/CAM technologies.
International Poster Competition, First place

2016/04　American Academy of Cosmetic Dentistry　Evaluation of properties of restorations using CAD/3D printing technologies.
第72回日本矯正歯科学会大会・優秀発表賞

2013/10　日本矯正歯科学会　新しい形状記憶・超弾性合金(Ti-Mo-Sn-Zr合金)の生体適合性評価
The 11th Asian BioCeramics Symposium (ABC2011) ABC Award

2011/11　National Institute for Materials Science
デンツプライ賞

2011/09　日本口腔インプラント学会
優秀ポスター賞

2010/09　日本金属学会
平成17年度優秀論文賞

2006/10　東北矯正歯科学会

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Papers 140

Antibacterial properties of TiO2 layers formed by Au-sputtering and thermal oxidation of titanium under visible light Peer-reviewed

T. Ueda, R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

J. Jpn. Inst. Metals and Mater.　88　(12)　314-323　2024/12

DOI： 10.2320/jinstmet.JC202405 　
Development of segmented titanium oxynitride layer with spinform surfaces exhibiting antibacterial properties

Masami Hashimoto, Norio Yamaguchi, Soma Hashimoto, Hidenobu Murata, Satoshi Kitaoka, Daisaku Yokoe, Taishi Ito, Takeharu Kato, Hiroyasu Kanetaka, Hideki Kakisawa

Journal of the Ceramic Society of Japan　132　(12)　681-689　2024/12/01
Publisher: Ceramic Society of Japan
DOI： 10.2109/jcersj2.24090 　

ISSN： 1882-0743

eISSN： 1348-6535
Reduction of aerosol and droplet dispersions using intraoral and extraoral vacuums for dental treatments with face-up, diagonal and upright positions

Tomonari Kajita, Kenji Kikuchi, Hiromitsu Morishima, Jun Watanabe, Yoko Iwamatsu-Kobayashi, Hiroyasu Kanetaka, Wataru Yashiro, Kensuke Yamauchi, Hiroshi Egusa

BMC Oral Health　24　(1)　2024/11/17
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12903-024-04911-5 　

eISSN： 1472-6831
Enhancing Titanium Osteoconductivity by Alkali-Hot Water Treatment. International-journal

Li Chang, Peng Chen, Takayuki Mokudai, Masakazu Kawashita, Itaru Mizoguchi, Hiroyasu Kanetaka

ACS omega　9　(44)　44568-44576　2024/11/05

DOI： 10.1021/acsomega.4c06702 　

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Titanium and its alloys are essential in orthopedic and dental treatments owing to their high strength, corrosion resistance, and superior biocompatibility compared with those of other metals. However, titanium alloys are bioinert. Previous studies have indicated that alkali treatment (AT) is a straightforward method to create a surface oxidization layer on titanium, thereby improving its bioactivity. Herein, alkali-hot water pretreatment was used to enhance the osteoconductivity of titanium and to identify a simple and efficient means of enhancing the interaction between osteoblasts and implants for clinical applications. Commercial pure titanium plates were ground (CP Ti) and subjected to alkali solution and hot water treatments (AWT). Single-process CP Ti specimens were prepared via either AT or hot water treatment (WT). Network-like structural features were observed in the AT specimens and were further refined and densified in the AWT specimens. Water contact angle testing revealed that the hydrophilicity of the titanium specimen (80° for CP Ti) increased by 19° for the AT specimens but decreased by 59° for the AWT specimens. Mouse preosteoblasts (MC3T3-E1 cells) were used for in vitro evaluation. After 24 h of culturing, the number of attached MC3T3-E1 cells on the AWT specimens was 1.5 times larger than that on the CP Ti specimens, suggesting that the alkali-hot water treatment enhanced the initial cell attachment. Cell proliferation evaluation indicated that fewer cells were detected in the AT and AWT specimens compared with those in the CP Ti or WT specimens. However, osteogenic differentiation evaluation on day 10 revealed a 1.5-fold higher alkaline phosphatase expression in cells cultured on the AWT specimens than in cells cultured on the CP Ti specimens. These findings demonstrate the good cytocompatibility and osteoconductivity of AWT Ti, highlighting its benefits in orthopedics and dental treatments.
Pure copper coating by multibeam directed energy deposition with blue lasers for antimicrobial effect

Tamaki Yoshida, Yuji Sato, Keisuke Takenaka, Peng Chen, Hiroyasu Kanetaka, Takayuki Mokudai, Masahiro Tsukamoto

Journal of Laser Applications　36　(4)　2024/11/01

DOI： 10.2351/7.0001588 　

ISSN： 1042-346X
Radical Scavenging Capacity and In Vitro Cytoprotective Effects of Great Salt Lake-Derived Processed Mineral Water. International-journal

Takayuki Mokudai, Seiko Nakagawa, Hiroyasu Kanetaka, Kazuo Oda, Hiroya Abe, Yoshimi Niwano

Antioxidants (Basel, Switzerland)　13　(10)　2024/10/18

DOI： 10.3390/antiox13101266 　

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The Great Salt Lake, located in Utah, USA, is a saltwater lake with no outlet and is surrounded by vast mountains and salt deserts. We aimed to use Great Salt Lake-derived processed mineral water (hereafter termed as GSL-MW) for maintaining oral health. Therefore, we examined its radical scavenging activity as an antioxidant and its cytoprotective effect on human gingival fibroblasts (hGFs). The scavenging activity against O2•- radicals was determined by an electron spin resonance (ESR)-spin trapping technique using two kinds of O2•- generation systems; however, we could not reach any concrete conclusion because of the interference caused by GSL-MW in both systems. Detection of ·OH radicals using the ESR-spin trapping technique and kinetic analyses using double-reciprocal plots (corresponding to Lineweaver-Burk plots that are used to represent enzyme kinetics) revealed that GSL-MW has the ability to scavenge ·OH radicals. GSL-MW also showed a weak 2,2-diphenyl-1-picrylhydrazyl (DPPH; a stable radical)-scavenging activity. Regarding the cytoprotective effects, subconfluent hGFs pretreated with 10× and 100× dilutions of GSL-MW for 3 min and then exposed to harsh environmental conditions, such as pure water or 100 μM H2O2 for 3 min, showed enhanced cell viability rate. Moreover, 10× and 100× dilutions of GSL-MW reduced oxidative damage in confluent hGFs exposed to 12.5 and 25 mM H2O2. Our findings show that GSL-MW has antioxidant potential and cytoprotective effects on hGFs, suggesting that GSL-MW can be used to maintain oral health.
矯正学的歯の移動に伴う痛みが歯根膜触覚に与える影響脳磁図による脳科学的評価

島田栄理遣, 金高弘恭, 日原大貴, 菅野彰剛, 中里信和, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　83回　177-177　2024/10
Publisher: (公社)日本矯正歯科学会
Radical generation and bactericidal activity of nanobubbles produced by ultrasonic irradiation of carbonated water. International-journal

Takayuki Mokudai, Michi Kawada, Daisuke Tadaki, Ayumi Hirano-Iwata, Hiroyasu Kanetaka, Hiroshi Fujimori, Emiko Takemoto, Michio Niwano

Ultrasonics sonochemistry　103　106809-106809　2024/02

DOI： 10.1016/j.ultsonch.2024.106809 　

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Our previous study showed that nanobubbles (NBs) encapsulating CO2 gas have bactericidal activity due to reactive oxygen species (ROS) (Yamaguchi et al., 2020). Here, we report that bulk NBs encapsulating CO2 can be efficiently generated by ultrasonically irradiating carbonated water using a piezoelectric transducer with a frequency of 1.7 MHz. The generated NBs were less than 100 nm in size and had a lifetime of 500 h. Furthermore, generation of ROS in the NB suspension was investigated using electron spin resonance spectroscopy and fluorescence spectrometry. The main ROS was found to be the hydroxyl radical, which is consistent with our previous observations. The bactericidal activity lasted for at least one week. Furthermore, a mist generated by atomizing the NB suspension with ultrasonic waves was confirmed to have the same bactericidal activity as the suspension itself. We believe that the strong, persistent bactericidal activity and radical generation phenomenon are unique to NBs produced by ultrasonic irradiation of carbonated water. We propose that entrapped CO2 molecules strongly interact with water at the NB interface to weaken the interface, and high-pressure CO2 gas erupts from this weakened interface to generate ROS with bactericidal activity.
味刺激誘発磁界を用いたヒト味認識メカニズムの検討

関智水, 齋藤野乃, 島田栄理遣, 日原大貴, 北山ちひろ, 佐原資謹, 菅野彰剛, 金高弘恭, 五十嵐薫

日本生体磁気学会誌　37　(1)　136-137　2024
Publisher: 日本生体磁気学会
ISSN： 0915-0374
LaMer-model-based synthesis method for fine particles of octacalcium phosphate and related functional compounds

Taishi Yokoi, Tomoyo Goto, Tohru Sekino, Tomoka Hasegawa, Peng Chen, Hiroyasu Kanetaka, Kaname Yoshida, Masaya Shimabukuro, Masakazu Kawashita

CrystEngComm　2024
Publisher: Royal Society of Chemistry (RSC)
DOI： 10.1039/d4ce00663a 　

eISSN： 1466-8033

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We developed a new precipitation method based on the LaMer model for synthesising fine particles of plain octacalcium phosphate (OCP) and OCP with incorporated carboxylate ions.
Effects of pain associated with orthodontic tooth movement on tactile sensation of periodontal ligaments. International-journal

Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

Clinical oral investigations　28　(1)　36-36　2023/12/26

DOI： 10.1007/s00784-023-05469-2 　

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OBJECTIVES: Pain associated with orthodontic tooth movement reportedly reduces periodontal ligament tactile sensation. However, the mechanism associated with the central nervous system remains unclear. This study was conducted by measuring somatosensory evoked magnetic fields (SEFs) during mechanical stimulation of teeth as they were being moved by separator elastics. Findings clarified the effects of pain on periodontal ligament tactile sensation during orthodontic tooth movement. MATERIALS AND METHODS: Using magnetoencephalography, SEFs were measured during the application of mechanical stimuli to the mandibular right first molars of 23 right-handed healthy participants (0 h). Separator elastics were subsequently inserted into the mesial and distal interdental portions of the mandibular right first molars. The same mechanical stimuli were applied again 24 h later while the SEFs were measured (24 h). After each SEF measurements, pain was also evaluated using the Visual Analog Scale (VAS). RESULTS: The VAS values were significantly higher at 24 h than at 0 h (p < 0.05). No significant difference in the peak latencies was found between those obtained at 0 h and 24 h, but the intensities around 40.0 ms in the contralateral hemisphere were significantly lower at 24 h than at 0 h (p < 0.01). CONCLUSIONS: Pain associated with orthodontic tooth movement might suppress periodontal ligament tactile sensation in the primary somatosensory cortex. CLINICAL RELEVANCE: Pain associated with orthodontic tooth movement might affect periodontal ligament sensation, consequently causing discomfort during occlusion.
Proliferation and differentiation of MC3T3‐E1 cells on polymethyl methacrylate cements containing Fe₃O₄ and TiO₂ for hyperthermic treatment of metastatic bone tumors

Moe Kubota, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Tomoyuki Ogawa, Shin Saito, Balachandran Jeyadevan, Masaya Shimabukuro, Taishi Yokoi, Masakazu Kawashita

Journal of Biomaterials Applications　2023/10/09
Publisher: SAGE Publications
DOI： 10.1177/08853282231205681 　

ISSN： 0885-3282

eISSN： 1530-8022

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Polymethyl methacrylate (PMMA) bone cement is widely used to relieve pain caused by metastatic bone tumors. We previously found that PMMA bone cement containing 15 mass% or more of TiO₂ showed good apatite-forming ability, and 25 mass% or more of Fe₃O₄ generated sufficient heat for hyperthermia under an alternating current (AC) magnetic field. In this study, the cytocompatibility of PMMA bone cement with Fe₃O₄:TiO₂ weight ratios of 25:15 (F25T15-3/2-42) and 30:15 (F30T15-3/2-42) was evaluated using osteoblastic cells (MC3T3-E1). The proliferation and differentiation of MC3T3-E1 cells were suppressed for F25T15-3/2-42 and F30T15-3/2-42 compared to PMMA bone cement without Fe₃O₄ and TiO₂ (F0T0-3/2-42). The release of methyl methacrylate (MMA) monomers from F25T15-3/2-42 and F30T15-3/2-42 at 7 days was about 33 and 50 times higher than that from F0T0-3/2-42, respectively. The remarkable release of MMA monomers from F25T15-3/2-42 and F30T15-3/2-42 may be responsible for the suppressed proliferation and differentiation of MC3T3-E1 cells. The release of MMA monomers was not reduced when the MMA/PMMA weight ratio was decreased from 3/2 to 1/1, however, it was significantly reduced by increasing the content of benzoyl peroxide (BPO) and N, N-dimethyl- p-toluidine (DMPT) to 8 and 4 mass% against MMA, respectively. Proliferation and differentiation of MC3T3-E1 cells on PMMA-type cements containing Fe₃O₄ and TiO₂ with increased BPO and DMPT contents need to be investigated in the future; however, our findings will be useful for designing PMMA cements for the hyperthermic treatment of metastatic bone tumors.
Visible-light-induced antibacterial activity of carbon and nitrogen co-doped rutile TiO<inf>2</inf> films

Ryusuke Koizumi, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Mokudai, Takayuki Narushima

Thin Solid Films　780　2023/09/01

DOI： 10.1016/j.tsf.2023.139944 　

ISSN： 0040-6090
Visible-light-enhanced antibacterial activity of silver and copper co-doped titania formed on titanium via chemical and thermal treatments Peer-reviewed

K. Suzuki, M. Iwatsu, T. Mokudai, H. Kanetaka, M. Shimabukuro, T. Yokoi, M. Kawashita

Molecules　28　(2)　650-650　2023/01/09
Publisher: MDPI AG
DOI： 10.3390/molecules28020650 　

eISSN： 1420-3049

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Dental implants made of titanium (Ti) are used in dentistry, but peri-implantitis is a serious associated problem. Antibacterial and osteoconductive Ti dental implants may decrease the risk of peri-implantitis. In this study, titania (TiO2) co-doped with silver (Ag) at 2.5 at.% and copper (Cu) at 4.9 at.% was formed on Ti substrates via chemical and thermal treatments. The Ag and Cu co-doped TiO2 formed apatite in a simulated body fluid, which suggests osteoconductivity. It also showed antibacterial activity against Escherichia coli, which was enhanced by visible-light irradiation. This enhancement might be caused by the synergistic effect of the release of Ag and Cu and the generation of •OH from the sample. Dental implants with such a Ag and Cu co-doped TiO2 formed on their surface may reduce the risk of peri-implantitis.
味覚誘発磁界を用いた味覚認識の評価(Evaluation of Taste Perception Using Gustatory Evoked Magnetic Fields)

Sahara Yoshinori, Shimada Eriya, Hihara Hiroki, Kitayama Chihiro, Kanno Akitake, Kanetaka Hiroyasu

日本生体磁気学会誌　36　(1)　83-83　2023
Publisher: 日本生体磁気学会
ISSN： 0915-0374
味刺激時誘発磁界を用いたヒトの舌味受容の検討

佐原資謹, 島田栄理遣, 日原大貴, 北山ちひろ, 菅野彰剛, 金高弘恭

日本生体磁気学会誌　36　(1)　152-153　2023
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Visualization of droplets and aerosols in simulated dental treatments to clarify the effectiveness of oral suction devices

Jun Watanabe, Yoko Iwamatsu-kobayashi, Kenji Kikuchi, Tomonari Kajita, Hiromitsu Morishima, Kensuke Yamauchi, Wataru Yashiro, Hidekazu Nishimura, Hiroyasu Kanetaka, Hiroshi Egusa

Journal of Prosthodontic Research　2023
Publisher: Japan Prosthodontic Society
DOI： 10.2186/jpr.jpr_d_23_00013 　

ISSN： 1883-1958

eISSN： 1883-9207
Effect of niobium and oxygen contents on microstructure and mechanical properties of α+β-type Ti-(5–25)Nb-(0.5–1)O (mass%) alloys for biomedical applications Peer-reviewed

K. Ueda, M. Omiya, K. Kato, H. Kanetaka, T. Narushima

Mater. Trans.　64　(1)　138-146　2023/01

DOI： 10.2320/matertrans.MT-MLA2022020 　
Antibacterial properties of TiO2 layers formed by Au-sputtering and thermal oxidation of titanium under visible light Peer-reviewed

T. Ueda, R. Koizumi, K. Ueda, K. Ito, K. Ogasawara, H. Kanetaka, T. Narushima

Mater. Trans.　63　(12)　155-164　2023/01

DOI： 10.2320/matertrans.MT-MLA2022006 　

ISSN： 1345-9678
Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip

Chihiro Kitayama, Eriya Shimada, Hiroki Hihara, Akitake Kanno, Nobukazu Nakasato, Yoshimichi Imai, Akimitsu Sato, Ryuta Kawashima, Kaoru Igarashi, Hiroyasu Kanetaka

PLOS ONE　17　(9)　e0274405-e0274405　2022/09/22
Publisher: Public Library of Science (PLoS)
DOI： 10.1371/journal.pone.0274405 　

eISSN： 1932-6203

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Background Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensation in patients with unilateral cleft lip to establish a new objective evaluation method. Methods Participants were 15 patients with unilateral cleft lip after cheiloplasty (UCL group), and 30 healthy young subjects (control group). Five points of the upper and lower lips were stimulated electrically to measure somatosensory evoked magnetic fields (SEFs). The sources of the magnetic fields were modeled as single equivalent current dipoles (ECDs). ECDs located on the central sulcus by superimposition on magnetic resonance images were analyzed. Latency and intensity at 50–75 ms (cP60m) observed in the UCL group were compared with those in the control group. Thresholds of tactile stimuli in both groups were obtained using Semmes–Weinstein monofilaments for subjective sensory evaluation. Results No significant difference was found in the intensity of the cP60m or subjective evaluation between the groups. However, the latency of the cP60m was significantly longer in the upper lip of the UCL group than in the control group. Conclusions SEFs showed a difference in lip sensation between the UCL group and the control group, suggesting that longer latency might be caused by the effects of surgical scarring on the neurotransmission pathway. These results suggest SEFs as useful for the objective evaluation of lip sensations. This study might improve future surgical procedures and lip functions of patients with cleft lip.
Rationale and design for efficacy and safety evaluation of Bone-Anchored Maxillary Protraction (BAMP) for patients with unilateral cleft lip and palate with skeletal anterior crossbite: a single-arm, open-label, non-randomised prospective study protocol

Eriya Shimada, Hiroyasu Kanetaka, Kensuke Yamauchi, Tetsu Takahashi, Kotaro Nochioka, Kaoru Igarashi

BMJ Open　12　(9)　e061831-e061831　2022/09
Publisher: BMJ
DOI： 10.1136/bmjopen-2022-061831 　

ISSN： 2044-6055

eISSN： 2044-6055

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Introduction Bone-anchored maxillary protraction (BAMP) was devised recently as a method of direct maxillary protraction using anchor plates implanted in the maxilla and mandible without involving the teeth. Although several reports have described orthognathic effects of BAMP on patients with cleft lip and palate (CLP) with skeletal crossbite, none has described a study of Japanese patients with CLP or of BAMP treatment effects on speech in patients with CLP. This study, by performing BAMP treatment, and by evaluating speech function and skeletal and soft tissues, is intended to clarify BAMP efficacy and safety for patients with unilateral CLP (UCLP) who have skeletal crossbite. Methods and analysis This single-arm, open-label, non-randomised prospective study examines 20 patients with UCLP with skeletal crossbite (Wits appraisal ≤−5.0 mm). These 10–15 year-old participants had already undergone cheiloplasty, palatoplasty and bone grafting. The anchor plates are implanted in the zygomatic process in the maxilla and in the anterior part of the mandible. Two weeks after anchor plate implantation, maxillary protraction is started using elastics. Protraction is performed at 150 g per side at the start of protraction, 200 g per side from 1 month after the start of protraction and 250 g per side from 3 months after the start of protraction. The treatment period will be approximately 1½ years. Pretreatment and post-treatment, cephalometric analysis, speech evaluation, nasopharyngeal closure function evaluation and facial soft tissue evaluation will be performed to ascertain the effects of BAMP on patients with UCLP. Ethics and dissemination Ethical approval for this study has been received from Tohoku Certificated Review Board of Tohoku University, Japan, CRB2200003. The approval number is 2021-34-2. The results of this research shall be presented at domestic and international academic conferences, and be published to peer-reviewed journals. Trial registration number jRCTs022210007.
Somatosensory Evoked Magnetic Fields Induced by Electrical Palate Stimulation in Patients with Unilateral Cleft Lip and Palate after Palatoplasty

Eriya Shimada, Hiroki Hihara, Chihiro Kitayama, Akitake Kanno, Ryuta Kawashima, Akimitsu Sato, Yoshimichi Imai, Nobukazu Nakasato, Kaoru Igarashi, Hiroyasu Kanetaka

Neuroscience Research　184　30-37　2022/08
Publisher: Elsevier BV
DOI： 10.1016/j.neures.2022.08.002 　

ISSN： 0168-0102
切削器具が及ぼす浮遊エアロゾルの可視化と口腔外バキュームの有用性について

梶田倫功, 山内健介, 森島浩允, 野上晋之介, 渡辺隼, 小林洋子, 金高弘恭, 高橋哲

東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-52　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
歯科治療で発生するエアロゾル挙動の可視化

小林洋子, 渡辺隼, 梶田倫功, 山内健介, 金高弘恭, 江草宏, 五十嵐薫, 矢代航, 菊地謙次, 西村秀一, 森島浩允, 佐藤舜, 菅井優生

東北大学歯学雑誌　39/40/41　(2/1-2/1)　49-49　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
切削器具が及ぼす浮遊エアロゾルの可視化と口腔外バキュームの有用性について

梶田倫功, 山内健介, 森島浩允, 野上晋之介, 渡辺隼, 小林洋子, 金高弘恭, 高橋哲

東北大学歯学雑誌　39/40/41　(2/1-2/1)　52-52　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
口唇裂手術後の口唇領域に関する体性感覚誘発磁界

北山ちひろ, 日原大貴, 菅野彰剛, 中里信和, 五十嵐薫, 金高弘恭

東北大学歯学雑誌　39/40/41　(2/1-2/1)　48-48　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
Somatosensory evoked magnetic fields caused by mechanical stimulation of the periodontal ligaments. International-journal

Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi

Heliyon　8　(5)　e09464　2022/05

DOI： 10.1016/j.heliyon.2022.e09464 　

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The periodontal ligaments are very important sensory organ for our daily life such as perception of food size or hardness, determination of jaw position, and adjustment of masticatory strength. The sensory properties of the periodontal ligament, especially those of the maxillary and mandibular molars, have not yet been fully investigated. Somatosensory evoked magnetic fields (SEFs) can be measured and evaluated for latency and intensity to determine the sensory transmission characteristics of each body parts. However, previous reports on SEFs in the oral region have only reported differences in upper and lower gingival and lip sensations. In this study, the aim was to clarify these sensory characteristics by measuring SEFs during mechanical stimulation of the periodontal ligament in the maxillary and mandibular first molars. Somatosensory evoked magnetic fields were measured in the contralateral hemispheres of 33 healthy volunteers. Mechanical stimulation of the maxillary and mandibular right first molars, and the left wrist was performed with a specific handmade tool. The first peak latency for the mandibular first molars was 41.7 ± 5.70 ms (mean ± SD), significantly shorter than that for the maxillary first molars at 47.7 ± 7.36 ms. The peak intensity for the mandibular first molars was 13.9 ± 6.06 nAm, significantly larger than that for the maxillary first molars at 7.63 ± 3.55 nAm. The locations in the contralateral hemispheres showed no significant difference between the maxillary first molars and mandibular first molars. These locations were more anteroinferior and exterior than that of the wrist, as suggested by the brain homunculus. Neural signals from the mandibular periodontal ligaments pass faster and more intensely to the central nervous system than those from the maxillary periodontal ligaments, and may preferentially participate in adjustment of the occlusal force and the occlusal position.
Effects of aging on whole-body center of mass movement and lower limb joint kinematics and kinetics during deep-squat movement. International-journal

Keita Honda, Yusuke Sekiguchi, Satoko Shimazaki, Rie Suzuki, Takahiro Suzuki, Hiroyasu Kanetaka, Shin-Ichi Izumi

Journal of biomechanics　134　110996-110996　2022/03

DOI： 10.1016/j.jbiomech.2022.110996 　

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Deep-squat movement is one of the most important activities for independent living. Although a large range of motion of lower extremity joints in the sagittal plane is required for deep-squat movement, older individuals exhibit reduced mobility of lower limb joints. However, the effect of aging on deep-squat movement remains unclear. The purpose of this study was to investigate the age-related changes in the whole-body movement and lower extremity joint kinematics and kinetics during deep-squat movement. Twelve older and nineteen younger individuals performed the deep-squat movement, with knee flexion exceeding 100 degrees, and a motion analysis system and force plates collected their motion data. The median (interquartile range) age of older and younger individuals was 76.5 (3.3) and 30.0 (9.0) years, respectively. The deep-squat depth was significantly shallower in older individuals than in younger individuals (P < 0.05). Furthermore, older individuals exhibited smaller ankle dorsiflexion and knee flexion angles, larger trunk flexion angles, and greater forward displacement of the whole-body center of mass during deep-squat movement (P < 0.05). In terms of kinetic variables, older individuals exhibited smaller contributions of knee extension moment and larger contributions of hip extension moment to the support moment in the timing of the maximum support moment during deep-squat movement (P < 0.05). Our results indicated that older individuals have greater difficulty with deeper-squat movement and smaller contribution of knee extension moment to support body weight using trunk, hip, and ankle movements during deep-squat movement.
Indirect cytotoxicity evaluations of antibacterial raw silk fabric doped with calcium, copper and zinc on fibroblasts and osteoblasts

Hiroki Chigama, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Masakazu Kawashita

Journal of Biomaterials Applications　36　(8)　1417-1426　2022/03
Publisher: SAGE Publications
DOI： 10.1177/08853282211058941 　

ISSN： 0885-3282

eISSN： 1530-8022

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Antibacterial materials are widely used to prevent hospital-acquired infections. In our previous report, metal (calcium, copper or zinc)-doped raw silk fabrics were shown to possess strong antibacterial activities against Escherichia coli. However, antibacterial materials may occasionally be harmful to the human body; thus, in this study, we investigated the cytotoxicities of extracts from metal-doped raw silk fabrics with respect to fibroblasts and osteoblasts indirectly. Calcium-doped raw silk fabric demonstrated cytocompatibility with fibroblasts. Contrarily, copper- and zinc-doped raw silk fabrics remarkably decreased the cell densities of fibroblasts, indicating their cytotoxic effects. This observation could be attributed to the high concentrations of the released copper or zinc ions. However, calcium-, copper- and zinc-doped raw silk fabrics did not demonstrate any cytotoxic effects on osteoblasts because a high concentration of the serum alleviated the effects of these metal ions released from the fabrics. Thus, calcium-doped raw silk fabric is a promising antibacterial material that does not induce strong cytotoxicity. This study will facilitate the design of materials that are both antibacterial and safe.
味刺激時誘発磁界を用いたヒトの舌、口蓋におけるうま味受容の検討

日原大貴, 島田栄理遣, 佐原資謹, 菅野彰剛, 北山ちひろ, 中里信和, 金高弘恭

日本生体磁気学会誌　35　(1)　144-145　2022
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Mechanical property enhancement of the Ag–tailored Au–Cu–Al shape memory alloy via the ductile phase toughening

Ayano Toriyabe, Wan-Ting Chiu, Akira Umise, Masaki Tahara, Kenji Goto, Hiroyasu Kanetaka, Takao Hanawa, Hideki Hosoda

Intermetallics　139　107349-107349　2021/12
Publisher: Elsevier BV
DOI： 10.1016/j.intermet.2021.107349 　

ISSN： 0966-9795
口蓋形成術後の片側性唇顎口蓋裂患者の口蓋電気刺激による体性感覚誘導磁界反応

島田栄理遣, 日原大貴, 北山ちひろ, 菅野彰剛, 中里信和, 五十嵐薫, 金高弘恭

日本矯正歯科学会大会プログラム・抄録集　80回　190-190　2021/11
Publisher: (公社)日本矯正歯科学会
口蓋形成術後の片側性唇顎口蓋裂患者の口蓋電気刺激による体性感覚誘導磁界反応

島田栄理遣, 日原大貴, 北山ちひろ, 菅野彰剛, 中里信和, 五十嵐薫, 金高弘恭

日本矯正歯科学会大会プログラム・抄録集　80回　190-190　2021/11
Publisher: (公社)日本矯正歯科学会
Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal

Kanae Suzuki, Taishi Yokoi, Misato Iwatsu, Maiko Furuya, Kotone Yokota, Takayuki Mokudai, Hiroyasu Kanetaka, Masakazu Kawashita

Journal of Asian Ceramic Societies　9　(4)　1-9　2021/10/08
Publisher: Informa UK Limited
DOI： 10.1080/21870764.2021.1979287 　

eISSN： 2187-0764
体性感覚誘発磁界を用いた歯科インプラント触圧覚受容の検討

日原大貴, 金高弘恭, 菅野彰剛, 島田栄理遣, 北山ちひろ, 中里信和, 佐々木啓一

臨床神経生理学　49　(5)　433-433　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
矯正学的歯の移動に伴う疼痛の脳機能学的評価

島田栄理遣, 金高弘恭, 日原大貴, 菅野彰剛, 中里信和, 五十嵐薫

臨床神経生理学　49　(5)　433-433　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
刺激時の疼痛における電気刺激に対する磁気刺激の優位性刺激皮膚面積の影響

阿部玄治, カショウシン, 森仁, 八島建樹, 金高弘恭, 出江紳一

臨床神経生理学　49　(5)　442-442　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
体性感覚誘発磁界を用いた歯科インプラント触圧覚受容の検討

日原大貴, 金高弘恭, 菅野彰剛, 島田栄理遣, 北山ちひろ, 中里信和, 佐々木啓一

臨床神経生理学　49　(5)　433-433　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
矯正学的歯の移動に伴う疼痛の脳機能学的評価

島田栄理遣, 金高弘恭, 日原大貴, 菅野彰剛, 中里信和, 五十嵐薫

臨床神経生理学　49　(5)　433-433　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
Effects of seat height on whole-body movement and lower limb muscle power during sit-to-stand movements in young and older individuals

Keita Honda, Yusuke Sekiguchi, Akiko Sasaki, Satoko Shimazaki, Rie Suzuki, Takahiro Suzuki, Hiroyasu Kanetaka, Shin-Ichi Izumi

Journal of Biomechanics　110813-110813　2021/10
Publisher: Elsevier BV
DOI： 10.1016/j.jbiomech.2021.110813 　

ISSN： 0021-9290
Cytotoxicity evaluation of iron nitride nanoparticles for biomedical applications. International-journal

Misaki Shibata, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Tomoyuki Ogawa, Masakazu Kawashita

Journal of biomedical materials research. Part A　109　(10)　1784-1791　2021/10

DOI： 10.1002/jbm.a.37171 　

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Magnetic nanoparticles are widely studied for their use in various therapeutic and diagnostic purposes. As biomaterials, their biocompatibility is as important as their magnetic properties. Iron nitride (Fex Ny ) has excellent magnetic properties, and thus Fex Ny nanoparticles could be useful as potential biomaterials. However, the biocompatibility of Fex Ny nanoparticles is yet to be investigated. In this study, we assessed the biocompatibility of Fex Ny nanoparticles by evaluating their direct-contact cytotoxicity compared with that of magnetite nanoparticles (MNPs). Rat fibroblasts were incubated with the nanoparticle samples dispersed in culture medium at concentrations of 10, 50, and 100 μg/ml. The DNA concentration measurement, MTT assay, and trypan blue exclusion test were conducted after days 1 and 3 of incubation. After day 1, the cell viability decreased, and cell death increased with increasing sample concentration when compared with the control. However, after day 3, there were no significant differences when compared with the control, irrespective of the sample concentrations. Further, there were no significant differences between the Fex Ny nanoparticles and MNPs at the same concentrations in all the cytotoxicity evaluation tests. Therefore, it is suggested that Fex Ny nanoparticles might be as cytocompatible as the conventional MNPs.
Hydrothermal synthesis and preliminary cytotoxicity assessment of gadolinium borate nanoparticles for neutron capture therapy

Keita Mikami, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Yoshifumi Saijo, Taishi Yokoi, Masakazu Kawashita

Journal of Nanoparticle Research　23　(9)　2021/09
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11051-021-05311-4 　

ISSN： 1388-0764

eISSN： 1572-896X
Proteomic identification of serum proteins to induce osteoconductivity of hydroxyapatite.

Yunting Wang, Yutaka Yoshida, Junichi Kamiie, Yukari Shiwaku, Osamu Suzuki, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Taishi Yokoi, Masakazu Kawashita

Dental materials journal　2021/08/03

DOI： 10.4012/dmj.2021-120 　

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We performed proteomic analysis of rat serum proteins adsorbed on hydroxyapatite (HAp) and α-alumina (α-Al2O3) in order to identify proteins that specifically adsorb onto HAp and control cellular responses. Proteins with either or both molecular weight of 22-32 kDa and computed isoelectric point of 5.0-5.5 were preferentially adsorbed on HAp. In total, 182 proteins were adsorbed on both HAp and α-Al2O3, of which 14 were highly enriched on HAp, whereas 68 were adsorbed only on HAp. Therefore, 82 (14+68) proteins were further evaluated by bioinformatics and literature-based analyses. We predicted that hepatocyte growth factor and angiopoietin-like protein 3 (ANGPTL3) are candidate proteins responsible for the osteoconductivity of HAp. Although ANGPTL3 promoted the attachment and spreading of MC3T3-E1 cells, it did not promote their proliferation and differentiation. Our results suggest that specific adsorption of ANGPTL3 on HAp induced osteoconductivity by enhancing the attachment and spreading of osteoblasts.
Bactericidal Activity of Bulk Nanobubbles through Active Oxygen Species Generation. International-journal

Masato Yamaguchi, Teng Ma, Daisuke Tadaki, Ayumi Hirano-Iwata, Yoshihiko Watanabe, Hiroyasu Kanetaka, Hiroshi Fujimori, Emiko Takemoto, Michio Niwano

Langmuir : the ACS journal of surfaces and colloids　2021/08/02

DOI： 10.1021/acs.langmuir.1c01578 　

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We investigated the bactericidal activity of bulk nanobubbles (NBs) using E. coli, a model bacterium. Bulk NBs were produced by forcing gas through a porous alumina membrane with an ordered arrangement of nanoscale straight holes in contact with water. NBs with different gas contents, including CO2, O2, and N2, were generated and evaluated for their bactericidal effects. The survival rate of E. coli was significantly reduced in a suspension of CO2-containing NB (CO2-NB water). The N2-NB water demonstrated a small amount of bactericidal behavior, but its impact was not as significant as that of CO2-NB water. When E. coli was retained in O2-NB water, the survival rate was even higher than that in pure water (PW). We investigated the generation of reactive oxygen species (ROS) in NB suspensions by electron spin resonance spectroscopy. The main ROS generated in the NB water were hydroxyl radicals and OH·, and the production of ROS was the strongest in CO2-NB water, which was consistent with the results of the bactericidal effect measurements. We assumed that NB mediated by ROS would exhibit bactericidal behavior and proposed a kinetic model to explain the retention time variation of the survival rate. The results calculated based on the proposed model matched closely with the experimental results.
In-vitro heat-generating and apatite-forming abilities of PMMA bone cement containing TiO2 and Fe3O4

Moe Kubota, Taishi Yokoi, Tomoyuki Ogawa, Shin Saito, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Balachandran Jeyadevan, Masakazu Kawashita

Ceramics International　47　(9)　12292-12299　2021/05
Publisher: Elsevier BV
DOI： 10.1016/j.ceramint.2021.01.080 　

ISSN： 0272-8842
Fabrication and evaluation of ascorbic acid phosphate-loaded spherical porous hydroxyapatite/octacalcium phosphate granules

Masanobu KAMITAKAHARA, Airi ISHII, Hideaki MATSUBARA, Masakazu KAWASHITA, Maiko FURUYA, Hiroyasu KANETAKA

Journal of the Ceramic Society of Japan　129　(1)　60-65　2021/01/01
Publisher: Ceramic Society of Japan
DOI： 10.2109/jcersj2.20170 　

ISSN： 1882-0743

eISSN： 1348-6535
Setting behaviour, mechanical properties and heat generation under alternate current magnetic fields of Fe 3 O 4 /TiO 2 /PMMA composite bone cement

Moe Kubota, Taishi Yokoi, Tomoyuki Ogawa, Shin Saito, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Balachandran Jeyadevan, Masakazu Kawashita

MEDICAL DEVICES & SENSORS　3　(6)　2020/12
Publisher: Wiley
DOI： 10.1002/mds3.10114 　

ISSN： 2573-802X

eISSN： 2573-802X
Comparison of handrail reaction forces between two different handrails during sit-to-stand movement in the elderly. International-journal Peer-reviewed

Tomohisa Kato, Yusuke Sekiguchi, Keita Honda, Shin-Ichi Izumi, Hiroyasu Kanetaka

Clinical biomechanics (Bristol, Avon)　80　105130-105130　2020/12
Publisher: Elsevier BV
DOI： 10.1016/j.clinbiomech.2020.105130 　

ISSN： 0268-0033

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BACKGROUND: The handrail is an effective means of assisting sit-to-stand movements. As some elderly people need force to support their body during sit-to-stand movements because of instability and weakness; however, few handrails are specifically shaped to generate more force and support the body. This study aimed to investigate the effect of a newly designed curved-angled handrail on the reaction force during sit-to-stand movements in the elderly. METHODS: Twenty-one elderly subjects (age range, 72-84 years) participated in the study. They performed sit-to-stand movements using a conventional vertical handrail and then the curved-angled handrail five times each. For each subject, body coordinate data were acquired and the handrail reaction force was measured using motion analysis and load sensors on the handrail. FINDINGS: The reaction forces generated in the anterior-posterior and upward-downward directions during sit-to-stand movements using the curved-angled handrail were significantly greater than those generated using the conventional vertical handrail (p < .001). INTERPRETATION: Compared with using the conventional vertical handrail, using the curved-angled handrail enhances the generated force during sit-to-stand movements.
Continuous release of O-2(-)/ONOO- in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation

Shota Sasaki, Yuexing Zheng, Takayuki Mokudai, Hiroyasu Kanetaka, Masanori Tachikawa, Makoto Kanzaki, Toshiro Kaneko

PLASMA PROCESSES AND POLYMERS　17　(10)　2020/10

DOI： 10.1002/ppap.201900257 　

ISSN： 1612-8850

eISSN： 1612-8869
Bactericidal Activity of TiO2 Nanotube Thin Films on Si by Photocatalytic Generation of Active Oxygen Species International-journal

Masato Yamaguchi, Hiroyuki Abe, Teng Ma, Daisuke Tadaki, Ayumi Hirano-Iwata, Hiroyasu Kanetaka, Yoshihiko Watanabe, Michio Niwano

LANGMUIR　36　(42)　12668-12677　2020/10

DOI： 10.1021/acs.langmuir.0c02225 　

ISSN： 0743-7463
Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells International-journal

Ryuji Owada, Saaya Awata, Kazutomo Suzue, Hiroyasu Kanetaka, Yohei Kakuta, Kazuhiro Nakamura

HELIYON　6　(9)　e04851　2020/09

DOI： 10.1016/j.heliyon.2020.e04851 　

ISSN： 2405-8440
低い座面からの立ち上がり動作時の身体重心運動制御における高齢者の特徴

本田啓太, 関口雄介, 嶋崎聡子, 鈴木里江, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　57　(特別号)　3-7　2020/07
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
深い座位姿勢からの立ち上がり動作における高齢者の安全性優位な身体重心速度の特性

関口雄介, 本田啓太, 嶋崎聡子, 鈴木里江, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　57　(特別号)　3-8　2020/07
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
Porosity and Tensile Properties of Rhizoid Porous Structure Fabricated Using Selective Laser Melting

Shinji Ishibashi, Kunio Shimada, Hiroyasu Kanetaka, Masaki Tsukuda, Takumi Mizoi, Masataka Chuzenji, Shoichi Kikuchi, Masayoshi Mizutani, Tsunemoto Kuriyagawa

INTERNATIONAL JOURNAL OF AUTOMATION TECHNOLOGY　14　(4)　582-591　2020/07

DOI： 10.20965/ijat.2020.p0582 　

ISSN： 1881-7629

eISSN： 1883-8022
Effects of shelf bar assistance on kinetic control during sit-to-stand in healthy young and elderly subjects International-journal Peer-reviewed

Yusuke Sekiguchi, Keita Honda, Thitiporn Phakdepiboon, Mao Jinde, Tomohisa Kato, Hiroyasu Kanetaka, Shin-ichi Izumi

JOURNAL OF BIOMECHANICS　106　109822-109822　2020/06

DOI： 10.1016/j.jbiomech.2020.109822 　

ISSN： 0021-9290

eISSN： 1873-2380
体性感覚誘発磁界を用いた口唇形成術後の口唇感覚の客観的評価 Peer-reviewed

北山ちひろ, 菅野彰剛, 日原大貴, 島田栄理遣, 金高弘恭, 中里信和, 五十嵐薫

日本口蓋裂学会雑誌　45　(2)　180-180　2020/05
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
Apatite formation and bacterial growth on raw silk fabric heated in argon gas International-journal Peer-reviewed

Hiroki Chigama, Taishi Yokoi, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka, Masakazu Kawashita

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　31　(6)　49-49　2020/05

DOI： 10.1007/s10856-020-06388-4 　

ISSN： 0957-4530

eISSN： 1573-4838
X-ray elastography by visualizing propagating shear waves Peer-reviewed

Chika Kamezawa, Tomokazu Numano, Yoshihiko Kawabata, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Hidemi Kato, Akio Yoneyama, Kazuyuki Hyodo, Wataru Yashiro

APPLIED PHYSICS EXPRESS　13　(4)　042004-042004　2020/04

DOI： 10.35848/1882-0786/ab7e06 　

ISSN： 1882-0778

eISSN： 1882-0786
Visible light-induced photocatalytic and antibacterial activity of N-doped TiO2 International-journal Peer-reviewed

Misato Iwatsu, Hiroyasu Kanetaka, Takayuki Mokudai, Toru Ogawa, Masakazu Kawashita, Keiichi Sasaki

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　108　(2)　451-459　2020/02

DOI： 10.1002/jbm.b.34401 　

ISSN： 1552-4973

eISSN： 1552-4981
Somatosensory evoked magnetic fields of periodontal mechanoreceptors International-journal Peer-reviewed

Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Eriya Shimada, Satoko Koeda, Ryuta Kawashima, Nobukazu Nakasato, Keiichi Sasaki

HELIYON　6　(1)　e03244　2020/01

DOI： 10.1016/j.heliyon.2020.e03244 　

ISSN： 2405-8440

eISSN： 2405-8440
In vitro evaluation of doxorubicin-eluting porous titania microspheres for transcatheter arterial chemoembolization Peer-reviewed

Masakazu Kawashita, Hoji Ueno, Shoma Handa, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka

JOURNAL OF ASIAN CERAMIC SOCIETIES　8　(1)　10-20　2020/01

DOI： 10.1080/21870764.2019.1695559 　

ISSN： 2187-0764
A simple and rapid detection system for oral bacteria in liquid phase for point-of-care diagnostics using magnetic nanoparticles Peer-reviewed

Loi Tonthat, Shunnosuke Takahashi, Hidehiko Onodera, Kazuhiko Okita, Shin Yabukami, Kotone Yokota, Maiko Furuya, Hiroyasu Kanetaka, Yoshinori Miura, Hideki Takahashi, Yoshihiko Watanabe, Ritsuko Akiyama

AIP ADVANCES　9　(12)　125325　2019/12

DOI： 10.1063/1.5130437 　

eISSN： 2158-3226
Enhancement of cell differentiation on a surface potential-controlled nitrogen-doped TiO2 surface Peer-reviewed

Masami Hashimot, Satoshi Kitaoka, Maiko Furuya, Hiroyasu Kanetaka, Kazuhiko Hoshikaya, Hayato Yamashita, Masayuki Abe

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　127　(9)　636-641　2019/09

DOI： 10.2109/jcersj2.19114 　

ISSN： 1882-0743

eISSN： 1348-6535
Visible-light-responsive antibacterial activity of Au-incorporated TiO2 layers formed on Ti-(0-10)at%Au alloys by air oxidation International-journal Peer-reviewed

Takatoshi Ueda, Kyosuke Ueda, Koyu Ito, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Mokudai, Yoshimi Niwano, Takayuki Narushima

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　107　(5)　991-1000　2019/05

DOI： 10.1002/jbm.a.36624 　

ISSN： 1549-3296

eISSN： 1552-4965
MRIにおける磁化率アーチファクトの定量評価 Peer-reviewed

沼野智一, 細田秀樹, 金高弘恭

生体医歯工学共同研究拠点成果報告書　平成30年度　130-130　2019/04
Publisher: 東京医科歯科大学生体材料工学研究所
Evaluation of Apatite-Forming Ability and Antibacterial Activity of Raw Silk Fabrics Doped with Metal Ions Peer-reviewed

Hiroki Chigama, Hiroyasu Kanetaka, Maiko Furuya, Kotone Yokota, Masakazu Kawashita

MATERIALS TRANSACTIONS　60　(5)　808-814　2019

DOI： 10.2320/matertrans.Y-M2019802 　

ISSN： 1345-9678

eISSN： 1347-5320
Surface structure and in vitro apatite-forming ability of titanium doped with various metals Peer-reviewed

Masakazu Kawashita, Yuta Iwabuchi, Kanae Suzuki, Maiko Furuya, Kotone Yokota, Hiroyasu Kanetaka

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS　555　558-564　2018/10

DOI： 10.1016/j.colsurfa.2018.07.027 　

ISSN： 0927-7757

eISSN： 1873-4359
Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells International-journal Peer-reviewed

Miho Mohara, Takayasu Kawasaki, Ryuji Owada, Takayuki Imai, Hiroyasu Kanetaka, Shin-ichi Izumi, Koichi Tsukiyama, Kazuhiro Nakamura

NEUROSCIENCE LETTERS　685　42-49　2018/10

DOI： 10.1016/j.neulet.2018.07.031 　

ISSN： 0304-3940

eISSN： 1872-7972
Control of surface potential and hydroxyapatite formation on TiO2 scales containing nitrogen-related defects Peer-reviewed

Masami Hashimoto, Takafumi Ogawa, Satoshi Kitaoka, Shunsuke Muto, Maiko Furuya, Hiroyasu Kanetaka, Masayuki Abe, Hayato Yamashita

ACTA MATERIALIA　155　379-385　2018/08

DOI： 10.1016/j.actamat.2018.05.072 　

ISSN： 1359-6454

eISSN： 1873-2453
Availability of cosmetic treatment using novel cosmetics-based material on patients with craniofacial concavity Peer-reviewed

Shigeto Koyama, Hiroyasu Kanetaka, Yoshinori Sagehashi, Keiichi Sasaki, Naoko Sato

JOURNAL OF PROSTHODONTIC RESEARCH　62　(3)　379-382　2018/07

DOI： 10.1016/j.jpor.2018.01.008 　

ISSN： 1883-1958

eISSN： 2212-4632
Development of Denture Implanted RFID Tag Antennas Peer-reviewed

Xu J, Sato H, Motoyoshi M, Suematu N, Kanetaka H, Yasui K, Chen Q

2018 IEEE International Workshop on Electromagnetics: Applications and Student Innovation Competition, iWEM 2018　2018
Publisher: IEEE
DOI： 10.1109/iWEM.2018.8536610 　
TiO2 microspheres containing magnetic nanoparticles for intra-arterial hyperthermia International-journal Peer-reviewed

Hiroyasu Kanetaka, Gengci Liu, Zhixia Li, Toshiki Miyazaki, Maiko Furuya, Tada-aki Kudo, Masakazu Kawashita

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　105　(8)　2308-2314　2017/11

DOI： 10.1002/jbm.b.33765 　

ISSN： 1552-4973

eISSN： 1552-4981
Effects of grab bar on utilized friction and dynamic stability when elderly people enter the bathtub International-journal Peer-reviewed

Yusuke Sekiguchi, Tomohisa Kato, Keita Honda, Hiroyasu Kanetaka, Shin-Ichi Izumi

CLINICAL BIOMECHANICS　47　7-13　2017/08

DOI： 10.1016/j.clinbiomech.2017.05.005 　

ISSN： 0268-0033

eISSN： 1879-1271
Cold atmospheric plasma enhances osteoblast differentiation International-journal Peer-reviewed

Kanako Tominami, Hiroyasu Kanetaka, Shota Sasaki, Takayuki Mokudai, Toshiro Kaneko, Yoshimi Niwano

PLOS ONE　12　(7)　e0180507　2017/07

DOI： 10.1371/journal.pone.0180507 　

ISSN： 1932-6203
In vitro evaluation of Ag-containing calcium phosphates: Effectiveness of Ag-incorporated beta-tricalcium phosphate International-journal Peer-reviewed

Ozkan Gokcekaya, Kyosuke Ueda, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Narushima

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　75　926-933　2017/06

DOI： 10.1016/j.msec.2017.02.059 　

ISSN： 0928-4931

eISSN： 1873-0191
Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields International-journal Peer-reviewed

Hiroki Hihara, Hiroyasu Kanetaka, Akitake Kanno, Satoko Koeda, Nobukazu Nakasato, Ryuta Kawashima, Keiichi Sasaki

PLOS ONE　12　(6)　e0179323　2017/06

DOI： 10.1371/journal.pone.0179323 　

ISSN： 1932-6203
歯周靱帯に対する体性感覚刺激により惹起される磁界(Somatosensory evoked magnetic fields for the periodontal ligaments)

Hihara Hiroki, Kanetaka Hiroyasu, Kanno Akitake, Nakasato Nobukazu, Kawashima Ryuta, Sasaki Keiichi

日本生体磁気学会誌　30　(1)　76-76　2017
Publisher: 日本生体磁気学会
ISSN： 0915-0374
脳皮質における歯周靱帯刺激に対する体性感覚の応答(Somatosensory evoked responses in the cerebral cortex to periodontal ligament stimulation)

Shimada Eriya, Kanetaka Hiroyasu, Kanno Akitake, Kawashima Ryuta, Nakasato Nobukazu, Igarashi Kaoru

日本生体磁気学会誌　30　(1)　77-77　2017
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Effect of fibronectin adsorption on osteoblastic cellular responses to. hydroxyapatite and alumina International-journal Peer-reviewed

Masakazu Kawashita, Maki Hasegawa, Tada-aki Kudo, Hiroyasu Kanetaka, Toshiki Miyazaki, Masami Hashimoto

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　69　1268-1272　2016/12

DOI： 10.1016/j.msec.2016.08.034 　

ISSN： 0928-4931

eISSN： 1873-0191
Formation of bioactive N-doped TiO2 on Ti with visible light-induced antibacterial activity using NaOH, hot water, and subsequent ammonia atmospheric heat treatment International-journal Peer-reviewed

Masakazu Kawashita, Naoko Endo, Tomoaki Watanabe, Toshiki Miyazaki, Maiko Furuya, Kotoe Yokota, Yuki Abiko, Hiroyasu Kanetaka, Nobuhiro Takahashi

COLLOIDS AND SURFACES B-BIOINTERFACES　145　285-290　2016/09

DOI： 10.1016/j.colsurfb.2016.05.017 　

ISSN： 0927-7765

eISSN： 1873-4367
Fibronectin adsorption on osteoconductive hydroxyapatite and non-osteoconductive alpha-alumina International-journal Peer-reviewed

Maki Hasegawa, Tada-aki Kudo, Hiroyasu Kanetaka, Toshiki Miyazaki, Masami Hashimoto, Masakazu Kawashita

BIOMEDICAL MATERIALS　11　(4)　045006-045006　2016/08

DOI： 10.1088/1748-6041/11/4/045006 　

ISSN： 1748-6041

eISSN： 1748-605X
Roles of charged particles and reactive species on cell membrane permeabilization induced by atmospheric-pressure plasma irradiation Peer-reviewed

Shota Sasaki, Makoto Kanzaki, Yutaro Hokari, Kanako Tominami, Takayuki Mokudai, Hiroyasu Kanetaka, Toshiro Kaneko

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(7)　07LG04-1-5　2016/07

DOI： 10.7567/JJAP.55.07LG04 　

ISSN： 0021-4922

eISSN： 1347-4065
Tracking system for magnetic wireless marker using field programmable gate array Peer-reviewed

S. Yabukami, K. Takahashi, T. Ozawa, O. Fujioka, T. Nagano, S. Hashi, H. Kanetaka

Journal of the Magnetics Society of Japan　39　(4)　156-160　2015/07
Publisher: The Magnetics Society of Japan
DOI： 10.3379/msjmag.1507R001 　

ISSN： 1882-2924

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A new tracking system for a wireless magnetic ribbon type marker has been developed by using high-speed analog-to-digital [A/D] converters and a field programmable gate array (FPGA) module. The quality factor of the resonated marker (ribbon: 38 mm in length and 4 mm in width) was about 130. The standard deviation (position accuracy) was smaller than ～1/10 that of the previous system because the sampling frequency of the A/D converters was more than 100 times higher and because the FPGA operated at high speed. The distance between the driving coil and the pickup coil array was ～820 mm, which was ～2.7 times larger than that in the previously reported system. The profile of the marker we obtained was relatively smooth and reasonable up to a distance of 475 mm from the pickup coil array.
温度制御式連続温熱刺激によるPC12細胞における神経突起形成の制御(Regulation of neuritogenesis in PC12 cells by temperature-controlled repeated thermal stimulation)

Kudo Tada-aki, Kanetaka Hiroyasu, Mochizuki Kentaro, Tominami Kanako, Nunome Shoko, Takagi Toshiyuki, Izumi Shin-ichi

The Journal of Physiological Sciences　65　(Suppl.1)　S130-S130　2015/03
Publisher: (一社)日本生理学会
ISSN： 1880-6546

eISSN： 1880-6562
Tracking a nasogastric tube inside a rabbit using a wireless ribbon marker Peer-reviewed

Yabukami S, Chiba T, Takahashi K, Kanetaka H, Nogami S, Hashi S, Yamauchi K, Ozawa T

Journal of the Magnetics Soceity of Japan　38　(2)　29-32　2014/02
Publisher: The Magnetics Society of Japan
DOI： 10.3379/msjmag.1402R009 　

ISSN： 1882-2924

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A new tracking system utilizing a nasogastric tube with a wireless resonated marker was developed. A narrow marker (2 mm wide and 37 mm long) was fabricated and inserted into a commercial nasogastric tube. A good quality factor of about 136 was obtained. Positional accuracy within about 10 mm was obtained when the marker was scanned for about 100 mm. The nasogastric tube was roughly tracked inside a rabbit. A reasonable and reproducible profile of the tube was measured when the tube was inserted through the mouth into the esophagus of the rabbit.
Pressure controlled clamp using shape memory alloy for minimal vessel invasion in blood flow occlusion. Peer-reviewed

Ye Zhang, Hiroyasu Kanetaka, Yuya Sano, Mitsuhiro Kano, Tadaaki Kudo, Takumi Sato, Yoshinaka Shimizu

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia　19　(1)　35-42　2013

DOI： 10.5761/atcs.oa.11.01873 　

ISSN： 1341-1098

eISSN： 2186-1005
Martensite variant reorientation of NiMnGa/silicone composites containing polystyrene foam particles Peer-reviewed

Yui Watanabe, Motoki Okuno, Yoshinaka Shimizu, Hiroyasu Kanetaka, Tomonari Inamura, Hideki Hosoda

Advanced Materials Research　409　645-650　2012

DOI： 10.4028/www.scientific.net/AMR.409.645 　

ISSN： 1022-6680
「磁性リボンを用いた位置検出システム」 Peer-reviewed

森修, 薮上信, 石井修, 金高弘恭, 小澤哲也, 枦修一郎

J Magn Soc Jpn　36　(3)　239-244　2012
Publisher: The Magnetics Society of Japan
DOI： 10.3379/msjmag.1205R013 　

ISSN： 1882-2924

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A position sensing system of nasogastric tube using a wireless magnetic ribbon type marker has been developed. A Qualityfactor of the marker is 121 which is 13 times higher than conventional LC resonated marker. Position accuracy within 6.4mm was obtained when the marker inside a commercial nasogastic tube was parallel translation to 100mm. The marker inside the tube was roughly tracked in esophagus and in trachea of human model.
Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway Peer-reviewed

Tada-aki Kudo, Hiroyasu Kanetaka, Kazutoshi Mizuno, Yasuhiro Ryu, Yoshiyuki Miyamoto, Shoko Nunome, Ye Zhang, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi

GENES TO CELLS　16　(11)　1121-1132　2011/11

DOI： 10.1111/j.1365-2443.2011.01556.x 　

ISSN： 1356-9597

eISSN： 1365-2443
Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy International-journal Peer-reviewed

Masakazu Kawashita, Naoko Matsui, Zhixia Li, Toshiki Miyazaki, Hiroyasu Kanetaka

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　99B　(1)　45-50　2011/10

DOI： 10.1002/jbm.b.31870 　

ISSN： 1552-4973
Synostosis of the Joint Between the Body and Greater Cornu of the Human Hyoid Bone Peer-reviewed

Hiroyasu Kanetaka, Yoshinaka Shimizu, Mitsuhiro Kano, Masayoshi Kikuchi

CLINICAL ANATOMY　24　(7)　837-842　2011/10

DOI： 10.1002/ca.21183 　

ISSN： 0897-3806
Wireless Magnetic Position-Sensing System Using Optimized Pickup Coils for Higher Accuracy Peer-reviewed

S. Hashi, S. Yabukami, H. Kanetaka, K. Ishiyama, K. I. Arai

IEEE TRANSACTIONS ON MAGNETICS　47　(10)　3542-3545　2011/10

DOI： 10.1109/TMAG.2011.2154313 　

ISSN： 0018-9464
形状記憶合金メッシュを用いた骨膜伸展骨形成法の検討 Peer-reviewed

山内健介, 野上晋之介, 田中謙光, 金氏毅, 宮本郁也, 高橋哲, 金高弘恭

日本口腔インプラント学会誌　24　(特別号)　279-279　2011/08
Publisher: (公社)日本口腔インプラント学会
ISSN： 0914-6695

eISSN： 2187-9117
Masseteric Nerve Injury Increases Expression of Brain-Derived Neurotrophic Factor in Microglia Within the Rat Mesencephalic Trigeminal Tract Nucleus International-journal Peer-reviewed

Hiroyuki Ichikawa, Tadasu Sato, Mitsuhiro Kano, Toshihiko Suzuki, Saburo Matsuo, Hiroyasu Kanetaka, Yoshinaka Shimizu

CELLULAR AND MOLECULAR NEUROBIOLOGY　31　(4)　551-559　2011/05

DOI： 10.1007/s10571-011-9648-7 　

ISSN： 0272-4340
磁性リボンを用いた位置検出システムの検討

森修, 中野弘道, 薮上信, 石井修, 小澤哲也, 枦修一郎, 金高弘恭

電気関係学会東北支部連合大会講演論文集　2011　244-244　2011
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2011.0_244 　
Pituitary adenylatecyclase-activating polypeptide-immunoreactive nerve fibers in the rat epiglottis and pharynx International-journal Peer-reviewed

Mitsuhiro Kano, Yoshinaka Shimizu, Yujiro Suzuki, Yusuke Furukawa, Hiroko Ishida, Miho Oikawa, Hiroyasu Kanetaka, Hiroyuki Ichikawa, Toshihiko Suzuki

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER　193　(6)　494-499　2011

DOI： 10.1016/j.aanat.2011.08.005 　

ISSN： 0940-9602

eISSN： 1618-0402
細長ワイヤレス磁気マーカによる生体用チューブの位置検出 Peer-reviewed

Sato R, Hayasaka Y, Yabukami S, Ozawa T, Kanetaka H, Hashi S

J Magn Soc Jpn　35　(2)　67-71　2011
Publisher: The Magnetics Society of Japan
DOI： 10.3379/msjmag.1101R009 　

ISSN： 1882-2924

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A position-detecting system made up of a nasogastric tube using a wireless LC resonated magnetic marker has been developed. The marker, consisting of an inductor and a capacitor without battery or electric wires, was installed inside a commercial nasogastric tube. A positioning accuracy within 7.1mm was obtained when the marker inside the tube was parallel translation to 100mm. The marker inside the tube was roughly tracked in the esophagus and trachea of a human model.
Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8a (dmu) ) International-journal Peer-reviewed

Tadasu Sato, Yoshinaka Shimizu, Mitsuhiro Kano, Toshihiko Suzuki, Hiroyasu Kanetaka, Leona W. G. Chu, Patrice D. Cote, Hidetoshi Shimauchi, Hiroyuki Ichikawa

CELLULAR AND MOLECULAR NEUROBIOLOGY　31　(1)　155-161　2011/01

DOI： 10.1007/s10571-010-9601-1 　

ISSN： 0272-4340
New Internalized Distraction Device for Craniofacial Plastic Surgery Using Ni-Free, Ti-Based Shape Memory Alloy International-journal Peer-reviewed

Hiroyasu Kanetaka, Yoshinaka Shimizu, Tada-aki Kudo, Ye Zhang, Mitsuhiro Kano, Yuya Sano, Hiroyuki Ichikawa, Hideki Hosoda, Shuichi Miyazaki

JOURNAL OF CRANIOFACIAL SURGERY　21　(6)　1839-1842　2010/11

DOI： 10.1097/SCS.0b013e3181f43eba 　

ISSN： 1049-2275
In Vitro Biocompatibility of Ni-Free Ti-Based Shape Memory Alloys for Biomedical Applications Peer-reviewed

Hiroyasu Kanetaka, Hideki Hosoda, Yoshinaka Shimizu, Tada-aki Kudo, Ye Zhang, Mitsuhiro Kano, Yuya Sano, Shuichi Miyazaki

MATERIALS TRANSACTIONS　51　(10)　1944-1950　2010/10

DOI： 10.2320/matertrans.M2010038 　

ISSN： 1345-9678

eISSN： 1347-5320
MPC polymer regulates fibrous tissue formation by modulating cell adhesion to the biomaterial surface Peer-reviewed

Ye Zhang, Hiroyasu Kanetaka, Yuya Sano, Mitsuhiro Kano, Tada-aki Kudo, Yoshinaka Shimizu

DENTAL MATERIALS JOURNAL　29　(5)　518-528　2010/09

DOI： 10.4012/dmj.2009-138 　

ISSN： 0287-4547
Analysis and improvement of detection accuracy for a wireless motion sensing system using integrated coil component Peer-reviewed

S. Hashi, K. Ishiyama, S. Yabukami, H. Kanetaka, K. I. Arai

JOURNAL OF APPLIED PHYSICS　107　(9)　2010/05

DOI： 10.1063/1.3337706 　

ISSN： 0021-8979
口唇裂・口蓋裂患児の摂食嚥下機能に関する検討 Peer-reviewed

金高弘恭, 幸地省子, 新井映子, 中條哲, 徳川宜靖

日本口蓋裂学会雑誌　35　(1)　28-34　2010/04
Publisher:
DOI： 10.11224/cleftpalate.35.28 　

ISSN： 0386-5185

eISSN： 2186-5701
Study on the LC marker composed of laminated amorphous ribbon core for a wireless magnetic motion capture system Peer-reviewed

S. Hashi, F. Kamisaka, S. Yabukami, H. Kanetaka, K. Ishiyama, K. I. Arai

INTERNATIONAL CONFERENCE ON MAGNETISM (ICM 2009)　200　2010

DOI： 10.1088/1742-6596/200/9/092008 　

ISSN： 1742-6588
Establishment of a stable 293 cell line exhibiting inducible expression of the BMP receptor, BMPRⅡ Peer-reviewed

Kudo T, Kanetaka H, Watanabe A, Okumoto A, Asano M, Zhang Y, Zhao F, Kano M, Shimizu Y, Tamura S, Hayashi H

Tohoku J Exp Med　2010
Phase Constitution and Mechanical Properties of Ti-(Cr, Mn)-Sn Biomedical Alloys Peer-reviewed

Yasuhiro Kusano, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2118-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2118 　

ISSN： 0255-5476
Phase Constituents of Ti-Cr-Au and Ti-Cr-Au-Zr Alloy Systems Peer-reviewed

Yuri Shinohara, Takuya Ishigaki, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2122-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2122 　

ISSN： 0255-5476
Effect of Nitrogen Addition on Mechanical Property of Ti-Cr-Sn Alloy Peer-reviewed

Yuichi Nakahira, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2126-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2126 　

ISSN： 0255-5476
Effect of Aging on Mechanical Properties of Ti-Mo-Al Biomedical Shape Memory Alloy Peer-reviewed

Hideki Hosoda, Makoto Taniguchi, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki

PRICM 7, PTS 1-3　654-656　2150-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2150 　

ISSN： 0255-5476
Self-Accommodation Morphology in Ti-Nb-Al Shape Memory Alloy Peer-reviewed

Tomonari Inamura, Hideki Hosoda, Hiroyasu Kanetaka, Hee Young Kim, Shuichi Miyazaki

PRICM 7, PTS 1-3　654-656　2154-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2154 　

ISSN： 0255-5476
Compression Behavior and Texture Development of Polymer Matrix Composites Based on NiMnGa Ferromagnetic Shape Memory Alloy Particles Peer-reviewed

Motoki Okuno, Tomonari Inamura, Hiroyasu Kanetaka, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2103-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2103 　

ISSN： 0255-5476
Jaw Tracking System Using Resonated Wireless Markers Peer-reviewed

S. Yabukami, H. Kanetaka, S. Hashi, K. I. Arai, T. Sato

IEEE TRANSACTIONS ON MAGNETICS　45　(10)　4880-4883　2009/10

DOI： 10.1109/TMAG.2009.2024637 　

ISSN： 0018-9464
Numerical Study on the Improvement of Detection Accuracy for a Wireless Motion Capture System Peer-reviewed

S. Hashi, S. Yabukami, H. Kanetaka, K. Ishiyama, K. I. Arai

IEEE TRANSACTIONS ON MAGNETICS　45　(6)　2736-2739　2009/06

DOI： 10.1109/TMAG.2009.2020541 　

ISSN： 0018-9464
介護予防「口腔機能向上」プログラム対象者選定項目と歯科医療ニーズとの関連―要介護者を対象とした分析― Peer-reviewed

野口有紀, 相田潤, 丹田奈緒子, 伊藤恵美, 金高弘恭, 小関健由, 小坂健

口腔衛生学会雑誌　59　(2)　111-117　2009/04
Publisher:
DOI： 10.5834/jdh.59.2_111 　

ISSN： 0023-2831
顎顔面領域に対するNiフリー形状記憶合金を利用した力学的応用に関する検討 Peer-reviewed

金高弘恭, 清水良央, 工藤忠明, 細田秀樹, 佐々木啓一

Journal of Oral Biosciences　50　(Suppl.)　120-120　2008/09
Publisher:
ISSN： 1349-0079

eISSN： 1880-3865
Orthodontic tooth movement in rats using Ni-free Ti-based shape memory alloy wire Peer-reviewed

Hiroyasu Kanetaka, Yoshinaka Shimizu, Hideki Hosoda, Ryo Tomizuka, Akihiro Suzuki, Sachiko Urayama, Tomonari Inamura, Shuichi Miyazaki, Teruko Takano-Yamamoto

JOURNAL OF THE JAPAN INSTITUTE OF METALS　72　(7)　503-509　2008/07

DOI： 10.2320/jinstmet.72.503 　

ISSN： 0021-4876

eISSN： 1880-6880
マグネシウム合金の生体材料応用

清水良央, 山本玲子, 向井敏司, 白井暢子, 狩野充浩, 千葉亜耶美, 金高弘恭, 菊地正嘉

日本実験力学会講演論文集　8　56-57　2008/06
Wireless magnetic motion capture system using multiple LC resonant magnetic markers with high accuracy Peer-reviewed

Shuichiro Hashi, Masaharu Toyoda, Shin Yabukami, Kazushi Ishiyama, Yasuo Okazaki, Ken Ichi Arai, Hiroyasu Kanetaka

SENSORS AND ACTUATORS A-PHYSICAL　142　(2)　520-527　2008/04

DOI： 10.1016/j.sna.2007.09.011 　

ISSN： 0924-4247
Development of a new ultra-precision-polished pure titanium mirror for dental treatment. Peer-reviewed

Kanetaka H, Suzuki A, Tomizuka R, Urayama S, Takano-Yamamoto T

Interface Oral Health Science 2007　355-356　2008/01
Effects of initially light and gradually increasing force on orthodontic tooth movement. Peer-reviewed

Tomizuka R, Kanetaka H, Shimizu Y, Suzuki A, Urayama S, Takano-Yamamoto T

Interface Oral Health Science 2007　181-182　2008/01
Osteoclast-mediated bone remodeling in guided bone regeneration using graft materials Peer-reviewed

Shimizu Y, Okayama K, Kano M, Kanetaka H, Kikuchi M

Interface Oral Health Science 2007　329-334　2008/01
The effects of orthopedic forces with self-contained SMA appliance on cranial suture in rat. Peer-reviewed

Urayama S, Kanetaka H, Shimizu Y, Suzuki A, Tomizuka R, Takano-Yamamoto T

Interface Oral Health Science 2007　353-354　2008/01
Histological evaluation of the effects of initially light and gradually increasing force on orthodontic tooth movement International-journal Peer-reviewed

Ryo Tomizuka, Yoshinaka Shimizu, Hiroyasu Kanetaka, Alkihiro Suzuki, Sachiko Urayama, Masayoshi Kikuchi, Hideo Mitani, Kaoru Igarashi

ANGLE ORTHODONTIST　77　(3)　410-416　2007/05

DOI： 10.2319/0003-3219(2007)077[0410:HEOTEO]2.0.CO;2 　

ISSN： 0003-3219

eISSN： 1945-7103
Orthodontic tooth movement in rats using Ni-free Ti-based shape memory alloy wire Peer-reviewed

Hiroyasu Kanetaka, Yoshinaka Shimizu, Hideki Hosoda, Ryo Tomizuka, Akihiro Suzuki, Shachiko Urayama, Tomonari Inamura, Shuichi Miyazaki, Teruko Takano-Yamamoto

MATERIALS TRANSACTIONS　48　(3)　367-372　2007/03

DOI： 10.2320/matertrans.48.367 　

ISSN： 1345-9678

eISSN： 1347-5320
Histological evaluation of the effects of initially light and gradually increasing force on orthodontic tooth movement Peer-reviewed

Tomizuka Ryo, Shimizu Yoshinaka, Kanetaka Hiroyasu, Suzuki Akihiro, Urayama Sachiko, Kikuchi Masayoshi, Mitani Hideo, Igarashi Kaoru

Angle Orthodontist　1056-1065　2006/12
Orthodontic buccal tooth movement by nickel-free titanium-based shape memory and superelastic alloy wire International-journal Peer-reviewed

Akihiro Suzuki, Hiroyasu Kanetaka, Yoshinaka Shimizu, Ryo Tomizuka, Hideki Hosoda, Shuichi Miyazaki, Osamu Okuno, Kaoru Igarashi, Hideo Mitani

ANGLE ORTHODONTIST　76　(6)　1041-1046　2006/11

DOI： 10.2319/083105-306 　

ISSN： 0003-3219

eISSN： 1945-7103
Effects of gradually increasing force generated by permanent rare earth magnets for orthodontic tooth movement International-journal Peer-reviewed

Ryo Tomizuka, Hiroyasu Kanetaka, Yoshinaka Shimizu, Akihiro Suzuki, Kaoru Igarashi, Hideo Mitani

ANGLE ORTHODONTIST　76　(6)　1004-1009　2006/11

DOI： 10.2319/071805-237 　

ISSN： 0003-3219

eISSN： 1945-7103
超精密鏡面加工による純チタン製口腔内用ミラーの開発 Peer-reviewed

金高弘恭, 鈴木章裕, 冨塚亮, 浦山佐知子, 五十嵐薫, 山本照子

東北大学歯学雑誌　25　(1)　34-40　2006/06
Publisher:
ISSN： 0287-3915
学童期の重度う蝕に起因した咬合崩壊を伴う成人女子症例に対してスケルタル・アンカレッジ・システムおよびデンタル・インプラントを用いた包括歯科治療 Peer-reviewed

馬淵量平, 河内満彦, 菅原準二, 金高弘恭, 西村真, 長坂浩

東北矯正歯科学会雑誌　13　(1)　8-16　2005/12
Publisher:
ISSN： 1340-2668
Age-related morphological changes in the human hyoid bone Peer-reviewed

Y Shimizu, H Kanetaka, YH Kim, K Okayama, M Kano, M Kikuchi

CELLS TISSUES ORGANS　180　(3)　185-192　2005

DOI： 10.1159/000088247 　

ISSN： 1422-6405
上下に磁界センサを分離した顎運動計測システムによる６自由度計測 Peer-reviewed

薮上信, 荒井薫, 金高弘恭, 辻真哉, 荒井賢一

日本応用磁気学会誌　28　(1)　711-717　2004/04
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.28.711 　

ISSN： 0285-0192

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We developed a jaw-tracking system consisting of two magnets and biaxial fluxgate sensors. One magnet is fastened to a tooth in the bottom jaw of the subject and another is fastened to the subject's forehead. The system can naturally detect movement of the jaw as a rigid body. We fabricated sensor arrays with separate upper and lower parts in order to obtain good position accuracy. Positional accuracy to within 0.1 mm was achieved as a rigid body using a jaw model. Six degrees of freedom and 100 Hz sensing cycles were achieved using one rigid marker (composed of two magnets), and achieved position accuracy to within 0.3 mm.
２個の永久磁石を用いた顎運動計測システムの測定誤差解析 Peer-reviewed

薮上信, 荒井薫, 金高弘恭, 辻真哉, 荒井賢一, 三谷英夫

日本応用磁気学会誌　27　(1)　765-770　2003/04
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.27.765 　

ISSN： 0285-0192

More details Close

We developed a new system to capture jaw movement. It consists of two magnets and biaxial fluxgate sensors. A magnet is fixed to a tooth in the bottom jaw of the subject and another is fixed to the subject's forehead. The system can naturally detect movement of the jaw as a rigid body, because it does not require such attachments as a clutch inside the mouth or a magnetic field sensor array in contact with the head. In this paper, we investigate five error sources of the jaw-tracking system, using a jaw model, and report the achievement of a positional accuracy of 1.5 mm and an axial accuracy of 2 degrees. Positional accuracy within 2 mm is achieved as a rigid body.
A new tracking system of jaw movement using two magnets Peer-reviewed

S Yabukami, H Kanetaki, N Tsuji, A Itagaki, M Yamaguchi, KI Arai, H Mitani

IEEE TRANSACTIONS ON MAGNETICS　38　(5)　3315-3317　2002/09

DOI： 10.1109/TMAG.2002.802301 　

ISSN： 0018-9464
正常咬合者の咀嚼能力と咬合接触面積および咬合力との関係について, -ATP吸光度法およびチューインガム法による検討- Peer-reviewed

金高弘恭, 三谷英夫

日本矯正歯科学会雑誌　61　(1)　14-21　2002/04
顎関節雑音に伴う顎機能異常が咀嚼能力に与える影響について ATP吸光度法及びチューインガム法による検討 Peer-reviewed

金高弘恭, 三谷英夫

日本顎関節学会雑誌　14　(1)　25-30　2002/04
Publisher:
DOI： 10.11246/gakukansetsu1989.14.25 　

ISSN： 0915-3004

eISSN： 1884-4308
複数磁気マーカを用いたモーションキャプチャシステムによる新型顎運動測定装置の開発 Peer-reviewed

金高弘恭, 薮上信, 河内満彦, 荒井賢一, 三谷英夫

Orthodontic Waves　61　(2)　110-117　2002/04
Publisher:
ISSN： 1344-0241
正常咬合者の咀嚼能力と咬合接触面積及び咬合力との関係について ATP吸光度法及びチューインガム法による検討 Peer-reviewed

金高弘恭, 三谷英夫

Orthodontic Waves　61　(1)　14-21　2002/02
Publisher:
ISSN： 1344-0241
外科的矯正治療による開咬症の舌位および頭位の変化, -テレメータシステムを用いて解析した３症例- Peer-reviewed

金高弘恭, 河内満彦, 川村仁, 三谷英夫

日本顎変形症学会雑誌　11　(1)　35-46　2001/04
Publisher:
DOI： 10.5927/jjjd1991.11.35 　

ISSN： 0916-7048

eISSN： 1884-5045
筋機能訓練法による口唇圧・舌圧の変化に関する研究ー外科的矯正治療を施した骨格性開咬症例を対象としてー Peer-reviewed

齋藤浩子, 河内満彦, 冨塚亮, 金高弘恭, 三谷英夫

東北矯正歯科学会雑誌　9　(1)　48-56　2001/04
前歯部開咬を伴う骨格性下顎前突症の舌位について無線テレメータシステムによる長時間解析 Peer-reviewed

金高弘恭, 河内満彦, 三谷英夫

日本矯正歯科学会雑誌　56　(1)　33-43　1997/02
Publisher:
ISSN： 0021-454X

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Misc. 273

Evaluation of taste perception for tongue using taste-evoked magnetic fields

関智水, 関智水, 齋藤野乃, 島田栄理遣, 島田栄理遣, 日原大貴, 北山ちひろ, 北山ちひろ, 佐原資謹, 菅野彰剛, 金高弘恭, 金高弘恭, 五十嵐薫, 五十嵐薫

日本生体磁気学会誌　37　(1)　2024

ISSN： 0915-0374
Evaluation of Taste Perception Using Gustatory Evoked Magnetic Fields

SAHARA Yoshinori, SHIMADA Eriya, HIHARA Hiroki, KITAYAMA Chihiro, KANNO Akitake, KANETAKA Hiroyasu

日本生体磁気学会誌　36　(1)　2023

ISSN： 0915-0374
口唇裂手術後の口唇領域に関する体性感覚誘発磁界

北山ちひろ, 日原大貴, 菅野彰剛, 中里信和, 五十嵐薫, 金高弘恭

東北大学歯学雑誌　39/40/41　(2/1-2/1)　48-48　2022/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
味刺激時誘発磁界を用いたヒトの舌、口蓋におけるうま味受容の検討

日原大貴, 島田栄理遣, 佐原資謹, 菅野彰剛, 北山ちひろ, 中里信和, 金高弘恭

日本生体磁気学会誌　35　(1)　144-145　2022
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Measurement of multiple bacteria species using magnetic nanoparticles by switching magnetic field

高橋隼之介, 小野寺英彦, 村山徹, TONTHAT L., 沖田和彦, 桑波田晃弘, 薮上信, 薮上信, 大坪和香子, 横田琴音, 横田琴音, 古谷真衣子, 金高弘恭, 三浦由則, 高橋英樹

日本磁気学会学術講演概要集　45th　2021

ISSN： 1882-2959
刺激時の疼痛における電気刺激に対する磁気刺激の優位性-刺激皮膚面積の影響-

阿部玄治, 阿部玄治, カショウシン, 森仁, 八島建樹, 金高弘恭, 出江紳一

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
体性感覚誘発磁界を用いた歯科インプラント触圧覚受容の検討

日原大貴, 金高弘恭, 菅野彰剛, 菅野彰剛, 島田栄理遣, 北山ちひろ, 中里信和, 中里信和, 佐々木啓一

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
矯正学的歯の移動に伴う疼痛の脳機能学的評価

島田栄理遣, 島田栄理遣, 金高弘恭, 金高弘恭, 日原大貴, 菅野彰剛, 菅野彰剛, 中里信和, 中里信和, 五十嵐薫, 五十嵐薫

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
Implementation of Face Shield (DATE Shield) For Prevention of Infection of COVID-19 By Collaboration of Engineering, Medical Engineering and Dentistry

中瀬博之, 安藤晃, 舘野沙弥, 中村肇, 厨川常元, 金高弘恭

設計工学　56　(2)　2021

ISSN： 0919-2948
体性感覚誘発磁界を用いた口唇形成術後の口唇感覚の客観的評価

北山ちひろ, 菅野彰剛, 日原大貴, 島田栄理遣, 金高弘恭, 中里信和, 五十嵐薫

日本口蓋裂学会雑誌　45　(2)　180-180　2020/05
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
プラズマ処理によるセラミックブラケット接着性の向上

板垣祐介, 金高弘恭, 沖野晃俊

生体医歯工学共同研究拠点成果報告書　令和元年度　85-85　2020/04
Publisher: 東京医科歯科大学生体材料工学研究所
前腕背側への磁気刺激と電気刺激による手関節背屈運動の運動学的分析

阿部玄治, 阿部玄治, XIAOQING Jia, TUERXUN Lina, 森仁, 八島建樹, 金高弘恭, 出江紳一, 出江紳一

臨床神経生理学(Web)　48　(5)　2020

ISSN： 2188-031X
口唇裂手術後の口唇感覚に関する体性感覚誘発磁界を用いた客観的評価

北山ちひろ, 菅野彰剛, 日原大貴, 島田栄理遣, 金高弘恭, 中里信和, 川島隆太, 五十嵐薫

日本生体磁気学会誌　33　(1)　161-163　2020
Publisher: 日本生体磁気学会
ISSN： 0915-0374
口腔機能発達不全症と客観的口腔機能評価指標との関わりについて

板垣祐介, 金高弘恭, 島田栄理遣, 臼井ちひろ, 相田潤, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　78回　160-160　2019/11
Publisher: (公社)日本矯正歯科学会
チタン表面に形成した銅ドープTiO2層のアパタイト形成能と可視光応答型抗菌性

川下将一, 金高弘恭

日本歯科理工学会誌　38　(Special Issue74)　50-50　2019/09
Publisher: (一社)日本歯科理工学会
ISSN： 1884-4421
チタン表面に形成した銅ドープTiO2層のアパタイト形成能と可視光応答型抗菌性

川下将一, 金高弘恭

日本歯科理工学会誌　38　(Special Issue74)　50-50　2019/09
Publisher: (一社)日本歯科理工学会
ISSN： 1884-4421
医療機関として、今、求められるホームページのあり方とは? 平成30年医療広告ガイドライン改正のポイント

金高弘恭, 公益社団法人日本矯正歯科学会倫理, 裁定委員会

甲北信越矯正歯科学会雑誌　27　(1)　71-71　2019/06
Publisher: 甲北信越矯正歯科学会
ISSN： 1340-2366
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第1報) 資料採得環境について

丹原惇, 内野夏子, 吉田章太, 朝日藤寿一, 石渡靖夫, 岩田敏男, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 齋藤功

日本口蓋裂学会雑誌　44　(2)　111-111　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第2報) 資料採得時期について

内野夏子, 丹原惇, 吉田章太, 朝日藤寿一, 石渡靖夫, 岩田敏男, 大久保和美, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 星和人, 齋藤功

日本口蓋裂学会雑誌　44　(2)　111-111　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第3報) 共通プロトコール策定への意見

吉田章太, 丹原惇, 内野夏子, 大久保和美, 朝日藤寿一, 石渡靖夫, 岩田敏男, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 齋藤功

日本口蓋裂学会雑誌　44　(2)　112-112　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185
口蓋形態、咬合状態、および舌圧が片側性唇顎口蓋裂患者の構音に与える影響

山本奈加子, 金高弘恭, 板垣祐介, 今井啓道, 五十嵐薫

日本口蓋裂学会雑誌　44　(2)　123-123　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第1報) 資料採得環境について

丹原惇, 内野夏子, 吉田章太, 朝日藤寿一, 石渡靖夫, 岩田敏男, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 齋藤功

日本口蓋裂学会雑誌　44　(2)　111-111　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第2報) 資料採得時期について

内野夏子, 丹原惇, 吉田章太, 朝日藤寿一, 石渡靖夫, 岩田敏男, 大久保和美, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 星和人, 齋藤功

日本口蓋裂学会雑誌　44　(2)　111-111　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
矯正歯科領域の口唇裂・口蓋裂治療に関する資料採得の実態調査(第3報) 共通プロトコール策定への意見

吉田章太, 丹原惇, 内野夏子, 大久保和美, 朝日藤寿一, 石渡靖夫, 岩田敏男, 金高弘恭, 佐藤友紀, 谷川千尋, 中納治久, 春山直人, 真野樹子, 渡邉佳一郎, 齋藤功

日本口蓋裂学会雑誌　44　(2)　112-112　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
口蓋形態、咬合状態、および舌圧が片側性唇顎口蓋裂患者の構音に与える影響

山本奈加子, 金高弘恭, 板垣祐介, 今井啓道, 五十嵐薫

日本口蓋裂学会雑誌　44　(2)　123-123　2019/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
MRIにおける磁化率アーチファクトの定量評価

沼野智一, 細田秀樹, 金高弘恭

生体医歯工学共同研究拠点成果報告書　平成30年度　130-130　2019/04
Publisher: 東京医科歯科大学生体材料工学研究所
Porous Ti-based bulk metallic glass with excellent mechanical properties and good biocompatibility

Guoqiang Xie, Hiroyasu Kanetaka, Hidemi Kato, Fengxiang Qin, Wei Wang

INTERMETALLICS　105　153-162　2019/02

DOI： 10.1016/j.intermet.2018.12.002 　

ISSN： 0966-9795

eISSN： 1879-0216
Au蒸着Ti基板の大気酸化によるAu添加TiO₂膜の作製およびその可視光誘起抗菌能

上田隆統志, 佐藤直生, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 成島尚之

日本金属学会講演概要(CD-ROM)　164th　2019

ISSN： 2433-3093
生体材料としての窒素ドープ酸化チタンにおける機能性評価

岩津実里, 目代貴之, 目代貴之, 川下将一, 川下将一, 小川徹, 佐々木啓一, 庭野吉己, 庭野吉己, 金高弘恭, 金高弘恭

日本防菌防黴学会年次大会要旨集　46th　2019
Ti-Au合金表面に作製したAu添加TiO₂膜の可視光照射下における抗菌能

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 金高弘恭, 目代貴之, 目代貴之, 庭野吉己, 庭野吉己, 成島尚之

日本防菌防黴学会年次大会要旨集　46th　2019
試料内部の弾性率を画像化するX線エラストグラフィ法の基礎的研究

亀沢知夏, 亀沢知夏, 亀沢知夏, 兵藤一行, 兵藤一行, 沼野智一, 川畑義彦, 金高弘恭, 横田琴音, 古谷真衣子, 加藤秀実, 達久将成, 米山明男, 矢代航

応用物理学会東北支部学術講演会(CD-ROM)　74th　2019
高機能性インプラントの実現を目指した根状多孔質構造体の創成

溝井琢巳, 厨川常元, 石橋信治, 中善寺優昴, 佃将希, 前花英一, 金高弘恭, 佐々木理, 嶋田慶太, 水谷正義

精密工学会学術講演会講演論文集　2019　(0)　506-507　2019
Publisher: 公益社団法人精密工学会

More details Close

著者らは金属積層造形物内部に形成される空孔欠陥を利用した微細多孔質構造体を提案している．本研究では，造形条件による空孔形態の制御を試みた．その結果，レーザ走査経路を一方向に限定した場合には空孔の配列に顕著な指向性が生じることが分かった．加えて，空孔の配向化による機械特性の異方性発現も確認された．以上のことから，生体骨と同様の力学的機能性を有した高機能性インプラントの実現可能性が示された．
The Effects of a Mouthpiece for Dysphagia Rehabilitation on the Swallowing Function

OYAMA Hideki, KANETAKA Hiroyasu, IGARI Mitsurou, YABUKI Kouichi, YAMAGUCHI Kazuyoshi, KOYAMA Shigeto, IZUMI Shinichi

The Japanese Journal of Dysphagia Rehabilitation　22　(3)　237-248　2018/12
Publisher: 一般社団法人日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
銀または銅をドープしたチタンのアパタイト形成能と可視光照射による抗菌性の向上

鈴木香苗, 川下将一, 岩津実里, 目代貴之, 金高弘恭

日本バイオマテリアル学会大会予稿集　40回　132-132　2018/11
Publisher: 日本バイオマテリアル学会
新規超弾性形状記憶合金Ti-Mo-Sn-Zrの耐食性評価

布目祥子, 王鋭, 横田琴音, 古谷真衣子, 金高弘恭, 五十嵐薫

日本バイオマテリアル学会大会予稿集　40回　270-270　2018/11
Publisher: 日本バイオマテリアル学会
Tiベース合金の臨床応用実現に向けた医工学的検討

王鋭, 横田琴音, 古谷真衣子, 金高弘恭, 菊池雅彦

日本バイオマテリアル学会大会予稿集　40回　346-346　2018/11
Publisher: 日本バイオマテリアル学会
咬合時の接触点が歯根表面へ与える力学的影響―擬似三次元光弾性模型を用いた解析―

遠藤英昭, 千葉美麗, 伊藤秀美, 金高弘恭, 坂本信

日本実験力学会講演論文集　(18)　91‐92　2018/08/27

ISSN： 1346-4922
生体活性化処理による金属表面の構造変化に関する研究

金高弘恭, 佐々木啓一, 川下将一

東北大学金属材料研究所新素材共同研究開発センター共同利用研究報告書(CD-ROM)　2017　119‐120　2018/06/25
Development of high-strength porous Ti-based bulk metallic glasses for application as biomaterials-Effect of pore size on mechanical properties of porous Ti-based bulk metallic glasses-

XIE Guoqiang, XIE Guoqiang, XIE Guoqiang, 金高弘恭, 金高弘恭, 加藤秀実

東北大学金属材料研究所新素材共同研究開発センター共同利用研究報告書(CD-ROM)　2017　93‐94　2018/06/25
棚手すりが立ち上がり動作時の下肢の運動力学的制御に与える影響について

関口雄介, 本田啓太, 神出真緒, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-2　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
棚手すりが立ち上がり動作における質量中心速度に及ぼす影響

本田啓太, 関口雄介, 神出真緒, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-3　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
起立-着座動作における手摺の支持形態による手摺反力の違いについて

神出真緒, 関口雄介, 本田啓太, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-4　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
棚手すりが立ち上がり動作時の下肢の運動力学的制御に与える影響について

関口雄介, 本田啓太, 神出真緒, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-KP　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526
棚手すりが立ち上がり動作における質量中心速度に及ぼす影響

本田啓太, 関口雄介, 神出真緒, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-KP　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526
起立-着座動作における手摺の支持形態による手摺反力の違いについて

神出真緒, 関口雄介, 本田啓太, 加藤智久, 鈴木貴弘, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　55　(特別号)　3-KP　2018/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526
チタン-貴金属系形状記憶・超弾性合金の医療応用に向けた検討

金高弘恭, 細田秀樹

生体医歯工学共同研究拠点成果報告書　平成29年度　134-134　2018/04
Publisher: 東京医科歯科大学生体材料工学研究所
口腔内における分光学的断層画像計測法

石幡浩志, 金高弘恭, 佐々木啓一, 山田聡, 小山二三夫

生体医歯工学共同研究拠点成果報告書　平成29年度　106-106　2018/04
Publisher: 東京医科歯科大学生体材料工学研究所
チタン‐貴金属系形状記憶・超弾性合金の医療応用に向けた検討

金高弘恭, 細田秀樹

生体医歯工学共同研究拠点成果報告書　2017　134-134　2018/04
Publisher: 東京医科歯科大学生体材料工学研究所
口腔内における分光学的断層画像計測法

石幡浩志, 金高弘恭, 佐々木啓一, 山田聡, 小山二三夫

生体医歯工学共同研究拠点成果報告書　2017　106-106　2018/04
Publisher: 東京医科歯科大学生体材料工学研究所
大気酸化によりTi‐Au合金表面に作製したTiO₂膜の可視光照射下における抗菌能およびラジカル生成

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 庭野吉己, 成島尚之

日本金属学会講演概要(CD-ROM)　162nd　ROMBUNNO.217　2018/03/05

ISSN： 1342-5730
金属積層造形による高機能多孔質インプラントの開発

佃将希, 石橋信治, 溝井琢巳, 前花英一, 金高弘恭, 佐々木理, 嶋田慶太, 水谷正義, 厨川常元

精密工学会大会学術講演会講演論文集　2018　(0)　ROMBUNNO.G16-416　2018/03/01
Publisher: 公益社団法人精密工学会

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インプラントが抱える応力遮蔽現象の解決が期待される多孔質構造を金属積層造形によって作製した．本研究では複雑に連結した微細多孔質構造を造形すべく，CADによる多孔質構造の設計ではなく造形条件の制御による多孔質構造の造形を行った．結果として造形物内部の気孔発現には，粒度分布とレーザの走査速度が密接に関わっていることが明らかになり，造形条件の制御によって複雑に連結した微細多孔質構造の造形が可能となった．
大気酸化によりTi-Au合金表面に作製したTiO₂膜の可視光照射下における抗菌能およびラジカル生成

上田隆統志, 上田恭介, 伊藤甲雄, 小笠原康悦, 目代貴之, 金高弘恭, 庭野吉己, 成島尚之

日本金属学会講演概要(CD-ROM)　162nd　2018

ISSN： 2433-3093
MC3T3-E1 Cellular Response and Protein Detection on Surface Potential-Controlled TiO2 Scale in Serum-Containing Medium Peer-reviewed

M. Hashimoto, T. Ogawa, S. Kitaoka, S. Muto, M. Furuya, H. Kanetaka, M. Abe, H. Yamashita

Key Engineering Materials　782　218-223　2018
表面電位制御チタン上における骨芽細胞の応答およびタンパク質の検出

橋本雅美, 北岡諭, 小川貴史, 金高弘恭, 武藤俊介, 阿部真之

JFCC研究成果集　2018　33　2018
Evaluation of Apatite-forming Ability and Antibacterial Activity of Raw Silk Fabrics Doped with Metal Ions

千釜広己, 金高弘恭, 古谷真衣子, 横田琴音, 川下将一

粉体および粉末冶金　65　(8)　495‐501(J‐STAGE)-501　2018/01/01
Publisher: 一般社団法人粉体粉末冶金協会
DOI： 10.2497/jjspm.65.495 　

ISSN： 0532-8799
医療機関として,今,求められるホームページのあり方とは?~平成30年医療広告ガイドライン改正のポイント~

金高弘恭

甲北信越矯正歯科学会大会プログラム抄録　33rd　36‐37　2018
手すりを用いた高齢者起立動作の筋骨格シミュレーション解析

加藤智久, 藤井隆直, 中島求, 金高弘恭, 出江紳一

バイオエンジニアリング講演会講演論文集(CD-ROM)　30th　282　2017/12/13
種々の金属イオンを担持させた生糸織物のアパタイト形成能と抗菌性の評価

千釜広己, 川下将一, 古谷真衣子, 横田琴音, 金高弘恭

粉体粉末冶金協会講演概要集　2017　114　2017/11/09
溶液処理を用いたポリマー表面の親水化ならびにタンパク質吸着能評価

秋山洋輝, 黒田健介, 興戸正純, 金高弘恭

日本バイオマテリアル学会大会予稿集　39回　112-112　2017/11
Publisher: 日本バイオマテリアル学会
Phonetic Linguistic Investigation of Relationships between the Occurrence of Palatalized Articulation and Palatine Form, Occlusal Relation and Velopharyngeal Closure Function in Patients with Cleft Palate

YAMAMOTO Nakako, KANETAKA Hiroyasu, ITAGAKI Yusuke, IGARASHI Kaoru

Journal of Japanese Cleft Palate Association　42　(3)　215-224　2017/10
Publisher: Japanese Cleft Palate Association
ISSN： 0386-5185

eISSN： 2186-5701
Correlation between 3D Facial Morphology, Occlusal Relation, and Oral Function in Patients with Unilateral Cleft Lip and Unilateral Cleft Lip and Alveolus

ITAGAKI Yusuke, KANETAKA Hiroyasu, IGARASHI Kaoru

Journal of Japanese Cleft Palate Association　42　(3)　177-186　2017/10
Publisher: Japanese Cleft Palate Association
ISSN： 0386-5185

eISSN： 2186-5701
片側性口唇裂・口蓋裂患者における三次元顔面軟組織形態、咬合関係および口腔機能の相関について

板垣祐介, 金高弘恭, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　76回　152-152　2017/10
Publisher: (公社)日本矯正歯科学会
歯根膜への機械的刺激による体性感覚誘導磁界反応上下顎歯根膜感覚の性質の違いについて

島田栄理遣, 金高弘恭, 日原大貴, 菅野彰剛, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　76回　170-170　2017/10
Publisher: (公社)日本矯正歯科学会
フッ素含有環境下における新規形状記憶合金の耐食性評価

布目祥子, 王鋭, 横田琴音, 金高弘恭, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　76回　204-204　2017/10
Publisher: (公社)日本矯正歯科学会
咬合力が歯の形態へ与える力学的影響―擬似三次元光弾性模型を用いた解析―

遠藤英昭, 千葉美麗, 伊藤秀美, 金高弘恭, 坂本信

日本実験力学会講演論文集　(17)　155‐156　2017/08/28

ISSN： 1346-4922
Comparative study on castability of a new lost-wax casting process using 3D printer and a conventional method

Takada Hajime, Kanetaka Hiroyasu, Nunome Shoko, Katoh Hiroaki, Kikuchi Masahiko

Annals of Japan Prosthodontic Society　9　(3)　242-250　2017/07
Publisher: Japan Prosthodontic Society
ISSN： 1883-4426

eISSN： 1883-6860
Wireless Magnetic Position-Detection System With Four Excitation Coils

Yutaro Osaki, Shuichiro Hashi, Shin Yabukami, Hiroyasu Kanetaka, Kazushi Ishiyama

IEEE SENSORS JOURNAL　17　(14)　4412-4419　2017/07

DOI： 10.1109/JSEN.2017.2707388 　

ISSN： 1530-437X

eISSN： 1558-1748
低温大気圧プラズマ照射により生成される活性酸素種の定量評価

冨並香菜子, 金高弘恭, 目代貴之, 庭野吉己

東北大学歯学雑誌　35/36　(2/1)　61-69　2017/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
低温大気圧プラズマ照射により生成される活性酸素種の定量評価

冨並香菜子, 金高弘恭, 目代貴之, 庭野吉己

東北大学歯学雑誌　35/36　(2/1)　61-69　2017/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
肝動脈化学塞栓療法用多孔質TiO₂ビーズの合成

川下将一, 植野将司, 古谷真衣子, 横田琴音, 金高弘恭

粉体粉末冶金協会講演概要集　2017　41　2017/05/31
酸窒化処理による骨芽細胞活性の高い表面電荷制御チタンの開発

橋本雅美, 北岡諭, 小幡佳弘, 武藤俊介, 古谷真衣子, 金高弘恭

日本材料学会学術講演会講演論文集　66th　245‐246　2017/05/26
高齢者における手すりが立ち上がり動作時の運動力学的制御に与える影響について

関口雄介, 本田啓太, 加藤智久, 金高弘恭, 武田宏二, 筒井治雄, 出江紳一

The Japanese Journal of Rehabilitation Medicine　54　(特別号)　1-3　2017/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
手すりの形状の違いが高齢者の立ち上がり動作における質量中心制御に及ぼす影響

本田啓太, 関口雄介, 加藤智久, 金高弘恭, 武田宏二, 筒井治雄, 出江紳一

The Japanese Journal of Rehabilitation Medicine　54　(特別号)　1-4　2017/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
加齢および手すり形状の差異が起立動作時の上肢関節トルクに及ぼす影響

加藤智久, 本田啓太, 関口雄介, 武田宏二, 筒井治雄, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　54　(特別号)　1-5　2017/05
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
片側性口唇裂口蓋裂患者における三次元顔面形態、咬合関係および口腔機能の相関

板垣祐介, 金高弘恭, 五十嵐薫

日本口蓋裂学会雑誌　42　(2)　154-154　2017/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
プラズマ・メカノバイオロジーの医用応用に向けた科学的基盤の構築疾患治療からドラッグデリバリーまで医工学的手法を用いた物理化学的刺激に対する生体応答の解明

金高弘恭, 立川正憲, 金子俊郎, 高木敏行, 出江紳一

日本薬学会年会要旨集　137年会　(1)　162-162　2017/03
Publisher: (公社)日本薬学会
ISSN： 0918-9823
Somatosensory evoked magnetic fields for the periodontal ligaments

HIHARA Hiroki, KANETAKA Hiroyasu, KANNO Akitake, NAKASATO Nobukazu, KAWASHIMA Ryuta, SASAKI Keiichi

日本生体磁気学会誌　30　(1)　2017

ISSN： 0915-0374
Somatosensory evoked responses in the cerebral cortex to periodontal ligament stimulation

SHIMADA Eriya, KANETAKA Hiroyasu, KANNO Akitake, KANNO Akitake, KAWASHIMA Ryuta, NAKASATO Nobukazu, NAKASATO Nobukazu, IGARASHI Kaoru

日本生体磁気学会誌　30　(1)　2017

ISSN： 0915-0374
PMMA骨セメント用高生体活性酸化チタン粒子の開発

橋本雅美, 金髙弘恭

Fine ceramics report　35　(2)　78-81　2017
Publisher: 日本ファインセラミックス協会
ISSN： 0911-5269
IN VITRO PROPERTIES or Ag-CONTAINING CALCIUM PHOSPHATES

Ozkan Gokcekaya, Kyosuke Ueda, Takayuki Narushima, Kouetsu Ogasawara, Hiroyasu Kanetaka

ADVANCES IN CERAMIC ARMOR, BIOCERAMICS, AND POROUS MATERIALS　37　(4)　87-93　2017

DOI： 10.1002/9781119321682.ch10 　

ISSN： 0196-6219
Control of HAp formation and osteoconductivity on nitrogen-doped TiO2 scale formed by oxynitridation of ti

Masami Hashimoto, Satoshi Kitaoka, Yoshihiro Obata, Shunsuke Muto, Takafumi Ogawa, Maiko Furuya, Hiroyasu Kanetaka

Key Engineering Materials　758　86-89　2017
Publisher: Trans Tech Publications Ltd
DOI： 10.4028/www.scientific.net/KEM.758.86 　

ISSN： 1013-9826
Phase constitution and martensitic transformation behavior of Au-51Ti-18Co biomedical shape memory alloy heat-treated at 1173K to 1373K

Taywin Buasri, Hyunbo Shim, Masaki Tahara, Tomonari Inamura, Kenji Goto, Hiroyasu Kanetaka, Yoko Yamabe-Mitarai, Hideki Hosoda

Materials Science Forum　879　256-261　2017
Publisher: Trans Tech Publications Ltd
DOI： 10.4028/www.scientific.net/MSF.879.256 　

ISSN： 0255-5476
高分子材料アルゴン雰囲気中で焼成した生糸織物のアパタイト形成能および抗菌性の評価

千釜広己, 川下将一, 古谷真衣子, 横田琴音, 金高弘恭

日本バイオマテリアル学会大会予稿集　シンポジウム2016　107-107　2016/11
Publisher: 日本バイオマテリアル学会
Effect of surface charge of TiO2 particles on hydroxyapatite formation in simulated body fluid

Masami Hashimoto, Satoshi Kitaoka, Hiroyasu Kanetaka

ADVANCED POWDER TECHNOLOGY　27　(6)　2409-2415　2016/11

DOI： 10.1016/j.apt.2016.08.019 　

ISSN： 0921-8831

eISSN： 1568-5527
歯への応力が下顎骨に与える力学的影響―擬似三次元光弾性模型を用いた解析―

遠藤英昭, 千葉美麗, 伊藤秀美, 金高弘恭, 坂本信

日本実験力学会講演論文集　(16)　175‐177　2016/09/01

ISSN： 1346-4922
最新3Dプリンタ技術を応用した顎変形症治療におけるチームアプローチ

金高弘恭, 山内健介, 加藤裕光, 高橋哲, 五十嵐薫

日本歯科医師会雑誌　69　(5)　467-467　2016/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
Development of high performance MgFe alloy as potential biodegradable materials

Guoqiang Xie, Hajime Takada, Hiroyasu Kanetaka

MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING　671　48-53　2016/08

DOI： 10.1016/j.msea.2016.06.051 　

ISSN： 0921-5093

eISSN： 1873-4936
日米における歯学部学生の自己評価能力の比較

大山弘枝, 天雲太一, Lee Cliff, 竹内裕尚, 金高弘恭, 菊池雅彦, 佐々木啓一

日本歯科医学教育学会総会・学術大会プログラム・抄録集　35回　89-89　2016/07
Publisher: 日本歯科医学教育学会
Adsorption of Laminin on Hydroxyapatite and Alumina and the MC3T3-E1 Cell Response

Hiroka Fujita, Tada-aki Kudo, Hiroyasu Kanetaka, Toshiki Miyazaki, Masami Hashimoto, Masakazu Kawashita

ACS BIOMATERIALS SCIENCE & ENGINEERING　2　(7)　1162-1168　2016/07

DOI： 10.1021/acsbiomaterials.6b00190 　

ISSN： 2373-9878
身体重心運動からみた浴槽跨ぎ動作における加齢の影響と手すりの役割

本田啓太, 関口雄介, 加藤智久, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　(JARM2016)　I351-I351　2016/06
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
高齢者における手すりの使用が浴槽跨ぎ動作時のutilized frictionに及ぼす影響

関口雄介, 本田啓太, 加藤智久, 金高弘恭, 出江紳一

The Japanese Journal of Rehabilitation Medicine　(JARM2016)　I351-I351　2016/06
Publisher: (公社)日本リハビリテーション医学会
ISSN： 1881-3526

eISSN： 1881-8560
口蓋形態および咬合状態が片側性唇顎口蓋裂患者の構音に与える影響

山本奈加子, 金高弘恭, 板垣祐介, 今井啓道, 五十嵐薫

日本口蓋裂学会雑誌　41　(2)　96-96　2016/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
出生前診断からの唇裂児母子の心理的支援複数診療科、地域との連携

松本学, 今井啓道, 五十嵐薫, 金高弘恭, 幸地省子, 伊藤雅子

日本口蓋裂学会雑誌　41　(2)　100-100　2016/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
医療機器を開発してきた歯科医師で、かつPMDA職員として感じてきたこと

金高弘恭

日本歯科医学会誌　35　68-69　2016/03
Publisher: 日本歯科医学会
ISSN： 0286-164X
Apoptotic effects on cultured cells of atmospheric-pressure plasma produced using various gases

Kanako Tominami, Hiroyasu Kanetaka, Tada-aki Kudo, Shota Sasaki, Toshiro Kaneko

JAPANESE JOURNAL OF APPLIED PHYSICS　55　(1)　2016/01

DOI： 10.7567/JJAP.55.01AF03 　

ISSN： 0021-4922

eISSN： 1347-4065
Effect of Al and Cu Contents on Mechanical Properties of Au-Cu-Al Shape Memory Alloys

Hideki Hosoda, Takafumi Hori, Tomohiko Morita, Akira Umise, Masaki Tahara, Tomonari Inamura, Kenji Goto, Hiroyasu Kanetaka

JOURNAL OF THE JAPAN INSTITUTE OF METALS AND MATERIALS　80　(1)　27-36　2016

DOI： 10.2320/jinstmet.JB201511 　

ISSN： 0021-4876

eISSN： 1880-6880
Martensitic Transformation and Mechanical Properties of AuCuAl-Based Biomedical Shape Memory Alloys Containing Various Quaternary Elements

Akira Umise, Tomohiko Morita, Takahumi Hori, Kenji Goto, Hiroyasu Kanetaka, Masaki Tahara, Tomonari Inamura, Hideki Hosoda

JOURNAL OF THE JAPAN INSTITUTE OF METALS AND MATERIALS　80　(1)　71-76　2016

DOI： 10.2320/jinstmet.JB201512 　

ISSN： 0021-4876

eISSN： 1880-6880
顎顔面欠損患者における新規化粧品基剤の臨床評価

小山重人, 金高弘恭, 加藤裕光, 佐々木啓一

顎顔面補綴　38　(2)　66-67　2015/12
Publisher: (一社)日本顎顔面補綴学会
ISSN： 0389-4045
神経細胞分化誘導における温度制御式反復温熱刺激の効果の検討

工藤忠明, 金高弘恭, 板垣祐介, 布目祥子, 高木敏行, 出江紳一

日本矯正歯科学会大会プログラム・抄録集　74回　200-200　2015/11
Publisher: (公社)日本矯正歯科学会
Zrイオンプレーティング処理Ni-Tiワイヤーのフッ素含有環境下における耐食性評価

布目祥子, 金高弘恭, 上田恭介, 成島尚之, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　74回　219-219　2015/11
Publisher: (公社)日本矯正歯科学会
水酸アパタイトおよびα型アルミナに対するフィブロネクチンの吸着挙動および形態

長谷川蒔, 川下将一, 金高弘恭, 工藤忠明, 宮崎敏樹, 橋本雅美

日本バイオマテリアル学会大会予稿集　37回　295-295　2015/11
Publisher: 日本バイオマテリアル学会
窒素ドープ酸化チタンを形成させたチタンのアパタイト形成能と可視光下での抗菌性

川下将一, 遠藤真子, 渡邉友亮, 宮崎敏樹, 古谷真衣子, 横田琴音, 安彦友希, 金高弘恭, 高橋信博

日本バイオマテリアル学会大会予稿集　37回　244-244　2015/11
Publisher: 日本バイオマテリアル学会
運動に連動した連合性ペア磁気刺激が運動記憶に及ぼす影響に関する予備的検討 Peer-reviewed

浅尾章彦, 阿部玄治, 佐藤洋介, 田中尚文, 金高弘恭, 小山秀紀, 森和美, 森仁, 阿部利彦, 八島建樹, 佐藤眞平, 小助川博之, 高木敏行, 出江紳一

臨床神経生理学　43　(5)　471-471　2015/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
The Effect of Decortication for Periosteal Expansion Osteogenesis Using Shape Memory Alloy Mesh Device International-journal

Kensuke Yamauchi, Shinnosuke Nogami, Kenko Tanaka, Sou Yokota, Yoshinaka Shimizu, Hiroyasu Kanetaka, Tetsu Takahashi

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH　17　E376-E384　2015/10

DOI： 10.1111/cid.12250 　

ISSN： 1523-0899

eISSN： 1708-8208
温度制御式反復温熱刺激はPC12細胞の神経細胞分化を誘導する

工藤忠明, 金高弘恭

Journal of Oral Biosciences Supplement　2015　243-243　2015/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
Cytoprotective Effects of Grape Seed Extract on Human Gingival Fibroblasts in Relation to Its Antioxidant Potential (vol 10, e0134704, 2015) International-journal

Yusuke Katsuda, Yoshimi Niwano, Takuji Nakashima, Takayuki Mokudai, Keisuke Nakamura, Satomi Oizumi, Taro Kanno, Hiroyasu Kanetaka, Hiroshi Egusa

PLOS ONE　10　(9)　e0138394　2015/09

DOI： 10.1371/journal.pone.0138394 　

ISSN： 1932-6203
咬合筋の収縮が下顎骨に与える力学的影響―擬似三次元光弾性模型を用いた解析―

遠藤英昭, 千葉美麗, 伊藤秀美, 金高弘恭, 坂本信

日本実験力学会講演論文集　(15)　34-37　2015/08/28

ISSN： 1346-4922
Cytoprotective Effects of Grape Seed Extract on Human Gingival Fibroblasts in Relation to Its Antioxidant Potential International-journal

Yusuke Katsuda, Yoshimi Niwano, Takuji Nakashima, Takayuki Mokudai, Keisuke Nakamura, Satomi Oizumi, Taro Kanno, Hiroyasu Kanetaka, Hiroshi Egusa

PLOS ONE　10　(8)　e0134704　2015/08

DOI： 10.1371/journal.pone.0134704 　

ISSN： 1932-6203
Invitro evaluation of biocompatibility of Ti-Mo-Sn-Zr superelastic alloy International-journal

Shoko Nunome, Hiroyasu Kanetaka, Tada-aki Kudo, Kazuki Endoh, Hideki Hosoda, Kaoru Igarashi

JOURNAL OF BIOMATERIALS APPLICATIONS　30　(1)　119-130　2015/07

DOI： 10.1177/0885328215569892 　

ISSN： 0885-3282

eISSN： 1530-8022
Sol-gel synthesis of magnetic TiO2 microspheres and characterization of their in vitro heating ability for hyperthermia treatment of cancer

Gengci Liu, Masakazu Kawashita, Zhixia Li, Toshiki Miyazaki, Hiroyasu Kanetaka

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY　75　(1)　90-97　2015/07

DOI： 10.1007/s10971-015-3680-x 　

ISSN： 0928-0707

eISSN： 1573-4846
付加製造技術による歯科用3Dプリンタの精度評価

金高弘恭, 高田朝, 日原大貴, 大山弘枝, 菊池雅彦

特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　142回　101-101　2015/06
Publisher: (NPO)日本歯科保存学会
口唇裂の出生前診断は母親にいかなる心理学的影響を与えるのか

松本学, 今井啓道, 五十嵐薫, 金高弘恭, 幸地省子

日本口蓋裂学会雑誌　40　(2)　180-180　2015/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
Induction of Neurite Outgrowth in PC12 Cells Treated with Temperature-Controlled Repeated Thermal Stimulation International-journal

Tada-aki Kudo, Hiroyasu Kanetaka, Kentaro Mochizuki, Kanako Tominami, Shoko Nunome, Genji Abe, Hiroyuki Kosukegawa, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Toshiyuki Takagi, Shin-ichi Izumi

PLOS ONE　10　(4)　e0124024　2015/04

DOI： 10.1371/journal.pone.0124024 　

ISSN： 1932-6203
2G24 Contribution of the three-dimensional handrail in Sit-to-Stand movement

KATO Tomohisa, SUZUKI Rie, TAKEDA Kouji, SATO Minoru, KANETAKA Hiroyasu

2015　(27)　569-570　2015/01/08
Publisher: The Japan Society of Mechanical Engineers
チオ尿素水溶液中での水熱処理がNaOH処理チタンの表面構造と特性に及ぼす影響

川下将一, 古川崇, 宮崎敏樹, 目代貴之, 庭野吉己, 金高弘恭

日本セラミックス協会年会講演予稿集(CD-ROM)　2015　2015
FPGAを用いたワイヤレス磁気マーカ高速位置検出システム

冨並剛, 高橋和輝, 薮上信, 小澤哲也, 枦修一郎, 金高弘恭

電気関係学会東北支部連合大会講演論文集　2015　(0)　42-42　2015
Publisher: 電気関係学会東北支部連合大会実行委員会
DOI： 10.11528/tsjc.2015.0_42 　
Glial Reaction in the Spinal Cord of the Degenerating Muscle Mouse (Scn8a (dmu) ) International-journal

Tadasu Sato, Masatoshi Fujita, Yoshinaka Shimizu, Hiroyasu Kanetaka, Leona W. G. Chu, Patrice D. Cote, Hiroyuki Ichikawa

NEUROCHEMICAL RESEARCH　40　(1)　124-129　2015/01

DOI： 10.1007/s11064-014-1475-z 　

ISSN： 0364-3190

eISSN： 1573-6903
Phase constituent and reverse martensitic transformation temperature of PtTi-CoTi diffusion couple heat-treated at 1373K

Hideki Hosoda, Satoshi Tsutsumi, Masaki Tahara, Tomonari Inamura, Kenji Goto, Hiroyasu Kanetaka, Yoko Yamabe-Mitarai

Materials Research Society Symposium Proceedings　1760　163-168　2015
Publisher: Materials Research Society
DOI： 10.1557/opl.2015.59 　

ISSN： 0272-9172
線維芽細胞とマクロファージの共培養によるin vitro実験系における擬似炎症環境の構築

冨並香菜子, 金高弘恭, 布目祥子, 工藤忠明, 川下将一

日本バイオマテリアル学会大会予稿集　36回　123-123　2014/11
Publisher: 日本バイオマテリアル学会
三次元動作解析装置と連動した運動トリガ型経頭蓋磁気刺激が脳卒中患者の運動パフォーマンスに与える効果

阿部玄治, 鈴木栄三郎, 小山秀紀, 金高弘恭, 佐藤眞平, 小助川博之, 森和美, 森仁, 阿部利彦, 八島建樹, 高木敏行, 出江紳一

臨床神経生理学　42　(5)　319-319　2014/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
P-20 Evaluation for the usefulness of a new lost-wax casting process using additive manufacturing technology (3D printer)

Takada H, Kanetaka H, Nunome S, Katoh H, Kikuchi M

The journal of the Japanese Society for Dental Materials and Devices　33　(5)　406-406　2014/09
Publisher: The Japanese Society for Dental Materials and Devices (JSDMD)
ISSN： 1884-4421
In vitro apatite formation and visible-light photocatalytic activity of Ti metal subjected to chemical and thermal treatments

Masakazu Kawashita, Yuto Yokohama, Xinyu Cui, Toshiki Miyazaki, Hiroyasu Kanetaka

CERAMICS INTERNATIONAL　40　(8)　12629-12636　2014/09

DOI： 10.1016/j.ceramint.2014.04.109 　

ISSN： 0272-8842

eISSN： 1873-3956
咬筋が咬合時に歯槽骨に与える力学的影響―光弾性模型を用いた解析―

遠藤英昭, 千葉美麗, 伊藤秀美, 金高弘恭, 坂本信

日本実験力学会講演論文集　(14)　355-357　2014/08/28

ISSN： 1346-4922
歯科医師国家試験のグローバル化を目指して日米加の試験比較

日原大貴, 大山弘枝, 金高弘恭, 菊池雅彦, 佐々木啓一

日本歯科医学教育学会総会・学術大会プログラム・抄録集　33回　78-78　2014/07
Publisher: (一社)日本歯科医学教育学会
MC3T3-E1 and RAW264.7 cell response to hydroxyapatite and alpha-type alumina adsorbed with bovine serum albumin International-journal

Masakazu Kawashita, Jumpei Hayashi, Tada-aki Kudo, Hiroyasu Kanetaka, Zhixia Li, Toshiki Miyazaki, Masami Hashimoto

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　102　(6)　1880-1886　2014/06

DOI： 10.1002/jbm.a.34861 　

ISSN： 1549-3296

eISSN： 1552-4965
片側性口唇裂口蓋裂患者の咀嚼機能の成長変化に関する研究

板垣祐介, 金高弘恭, 五十嵐薫

日本口蓋裂学会雑誌　39　(2)　186-186　2014/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
Adsorption characteristics of bovine serum albumin onto alumina with a specific crystalline structure International-journal

Masakazu Kawashita, Junpei Hayashi, Zhixia Li, Toshiki Miyazaki, Masami Hashimoto, Hiroki Hihara, Hiroyasu Kanetaka

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　25　(2)　453-459　2014/02

DOI： 10.1007/s10856-013-5086-z 　

ISSN： 0957-4530

eISSN： 1573-4838
FPGAを用いたワイヤレス磁気マーカ高速位置検出システム

高橋和輝, 薮上信, 小澤哲也, 藤岡修, 枦修一郎, 金高弘恭

電気関係学会東北支部連合大会講演論文集　2014　(0)　71-71　2014
Publisher: 電気関係学会東北支部連合大会実行委員会
Martensitic transformation and related properties of AuTi-FeTi pseudobinary alloys

Taku Aoki, Masaki Tahara, Kenji Goto, Yoko Mitarai, Hiroyasu Kanetaka, Tomonari Inamura, Hideki Hosoda

Advanced Materials Research　922　25-30　2014
Publisher: Trans Tech Publications Ltd
DOI： 10.4028/www.scientific.net/AMR.922.25 　

ISSN： 1022-6680
手すりを用いた立ち座り動作のバイオメカニクス的分析立ち易さをサポートする手すり形状の開発

加藤智久, 鈴木里江, 佐藤稔, 金高弘恭

バイオメカニズム学術講演会予稿集　34回　37-40　2013/11
Publisher: バイオメカニズム学会
チタン金属表面への可視光応答型光触媒硫黄ドープ酸化チタンの形成

古川崇, 川下将一, 崔新宇, 宮崎敏樹, 金高弘恭

日本バイオマテリアル学会大会予稿集　35回　190-190　2013/11
Publisher: 日本バイオマテリアル学会
新規形状記憶合金の生体適合性評価

布目祥子, 金高弘恭, 工藤忠明, 冨並香菜子, 細田秀樹, 五十嵐薫

日本バイオマテリアル学会大会予稿集　35回　193-193　2013/11
Publisher: 日本バイオマテリアル学会
可視光応答型抗菌性窒素ドープチタン金属の作製とそのアパタイト形成能評価

横浜優人, 川下将一, 崔新宇, 宮崎敏樹, 金高弘恭

日本バイオマテリアル学会大会予稿集　35回　372-372　2013/11
Publisher: 日本バイオマテリアル学会
医療用モーションキャプチャに使用する磁気マーカの生体適合性評価

冨並香菜子, 金高弘恭, 工藤忠明, 藪上信, 布目祥子

日本バイオマテリアル学会大会予稿集　35回　446-446　2013/11
Publisher: 日本バイオマテリアル学会
Effect of ammonia or nitric acid treatment on surface structure, in vitro apatite formation, and visible-light photocatalytic activity of bioactive titanium metal International-journal

Masakazu Kawashita, Naoko Matsui, Toshiki Miyazaki, Hiroyasu Kanetaka

COLLOIDS AND SURFACES B-BIOINTERFACES　111　503-508　2013/11

DOI： 10.1016/j.colsurfb.2013.06.049 　

ISSN： 0927-7765
連続パルス磁場刺激による神経突起形成機構の調節

工藤忠明, 金高弘恭, 布目祥子, 高木敏行, 出江紳一

日本矯正歯科学会大会プログラム・抄録集　72回　204-204　2013/10
Publisher: (公社)日本矯正歯科学会
新しい形状記憶・超弾性合金(Ti-Mo-Sn-Zr合金)の生体適合性評価

布目祥子, 金高弘恭, 冨並香菜子, 工藤忠明, 細田秀樹, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　72回　217-217　2013/10
Publisher: (公社)日本矯正歯科学会
顎顔面領域の瘢痕に対するセラピーメーキャップの臨床的有用性評価に関する研究

金高弘恭, 幸地省子, 青木昭子, 提橋義則, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　72回　274-274　2013/10
Publisher: (公社)日本矯正歯科学会
口唇裂を有する患者に対するリアルタイム口唇動作解析システムの開発

板垣祐介, 金高弘恭, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　72回　274-274　2013/10
Publisher: (公社)日本矯正歯科学会
モーションキャプチャシステムと連動した運動同期型経頭蓋磁気刺激が運動記憶に及ぼす効果の予備的検討

阿部玄治, 鈴木栄三郎, 小山秀樹, 金高弘恭, 佐藤眞平, 森和美, 森仁, 阿部利彦, 佐々木利沙, 八島建樹, 竹内直行, 田中尚文, 出江紳一

臨床神経生理学　41　(5)　469-469　2013/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
体性感覚誘発磁場解析による口唇機能の加齢変化に関する研究

日原大貴, 金高弘恭, 小枝聡子, 齋藤正寛

特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　139回　238-238　2013/10
Publisher: (NPO)日本歯科保存学会
口唇刺激による体性感覚誘発磁場第一成分の加齢変化に関する検討

日原大貴, 金高弘恭, 小枝聡子, 後藤哲, 高橋哲, 斎藤正寛

Journal of Oral Biosciences Supplement　2013　149-149　2013/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
皮質骨穿孔を併用した形状記憶合金メッシュによる骨膜伸展骨形成法

山内健介, 野上晋之介, 田中謙光, 清水良央, 金高弘恭, 高橋哲

日本口腔インプラント学会誌　26　(特別号)　178-178　2013/08
Publisher: (公社)日本口腔インプラント学会
ISSN： 0914-6695

eISSN： 2187-9117
Self-activated mesh device using shape memory alloy for periosteal expansion osteogenesis International-journal

Kensuke Yamauchi, Tetsu Takahashi, Kenko Tanaka, Shinnosuke Nogami, Takeshi Kaneuji, Hiroyasu Kanetaka, Toshiki Miyazaki, Bernd Lethaus, Peter Kessler

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS　101B　(5)　736-742　2013/07

DOI： 10.1002/jbm.b.32876 　

ISSN： 1552-4973
頸椎椎弓形成術後患者における頭頸部屈曲時の動作解析回旋に着目して

西崎香苗, 内山悠美子, 深澤貴裕, 池上仁志, 金高弘恭, 出江紳一

日本脊髄障害医学会雑誌　26　(1)　12-17　2013/05
Publisher: 日本脊髄障害医学会
ISSN： 1348-3242
Effect of Autoclave and Hot Water Treatments on Surface Structure and In Vitro Apatite-Forming Ability of NaOH- and Heat-Treated Bioactiye Titanium Metal

Masakazu Kawashita, Naoko Matsui, Toshiki Miyazaki, Hiroyasu Kanetaka

MATERIALS TRANSACTIONS　54　(5)　811-816　2013/05

DOI： 10.2320/matertrans.M2013021 　

ISSN： 1345-9678

eISSN： 1347-5320
Position sensing system using LC resonated narrow marker

MORI O, NAKANO H, YABUKAMI S, OZAWA T, ISHII O, KANETAKA H, HASHI S

電気学会研究会資料. MAG, マグネティックス研究会　2013　(1)　45-48　2013/02/28
Pressure Controlled Clamp Using Shape Memory Alloy for Minimal Vessel Invasion in Blood Flow Occlusion

Ye Zhang, Hiroyasu Kanetaka, Yuya Sano, Mitsuhiro Kano, Tadaaki Kudo, Takumi Sato, Yoshinaka Shimizu

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY　19　(1)　35-42　2013/02

DOI： 10.5761/atcs.oa.11.01873 　

ISSN： 1341-1098
Mechanical Stress for Tissue Boundary among Enamel, Dentin and Dental Pulp

(13)　322-324　2013
Publisher: 日本実験力学会
ISSN： 1346-4922
Structure of Yttrium and Phosphorus-Containing Microspheres Prepared by Spray Dry Method

Kawashita Masakazu, Nakamura Kozue, Miyazaki Toshiki, Kanetaka Hiroyasu

International Journal of Materials and Chemistry　3　(3)　16-20　2013
Publisher: Scientific & Academic Publishing
DOI： 10.5923/s.ijmc.201303.03 　

ISSN： 2166-5346
209 Martensitic Transformation and Mechanical Properties of TiAuFe Alloys

AOKI Taku, GOTO Kenji, MITARAI Yoko, KANETAKA Hiroyasu, TAHARA Masaki, INAMURA Tomonari, HOSODA Hideki

The Proceedings of the Materials and processing conference　2013　(0)　_209-1_-_209-2_　2013
Publisher: The Japan Society of Mechanical Engineers
DOI： 10.1299/jsmemp.2013.21._209-1_ 　
Effect of Autoclave and Hot Water Treatment on Surface Structure and Apatite-Forming Ability of NaOH- and Heat-Treated Titanium Metals in Simulated Body Fluid

M. Kawashita, N. Matsui, T. Miyazaki, H. Kanetaka

BIOCERAMICS 24　529-530　570-+　2013

DOI： 10.4028/www.scientific.net/KEM.529-530.570 　

ISSN： 1013-9826
MC3T3-E1 cell response to hydroxyapatite and alpha-type alumina adsorbed with bovine serum albumin

Jumpei Hayashi, Masakazu Kawashita, Toshiki Miyazaki, Tada-aki Kudo, Hiroyasu Kanetaka, Masami Hashimoto

BIOCERAMICS 24　529-530　365-+　2013

DOI： 10.4028/www.scientific.net/KEM.529-530.365 　

ISSN： 1013-9826
Induction of Neuritogenesis in PC12 Cells by a Pulsed Electromagnetic Field via MEK-ERK1/2 Signaling

Tada-aki Kudo, Hiroyasu Kanetaka, Yoshinaka Shimizu, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Eizaburo Suzuki, Toshiyuki Takagi, Shin-ichi Izumi

CELL STRUCTURE AND FUNCTION　38　(1)　15-20　2013

DOI： 10.1247/csf.12030 　

ISSN： 0386-7196

eISSN： 1347-3700
パルス磁場刺激によるMEK-ERK1/2シグナル伝達経路を介したPC12細胞神経突起伸長の誘導

工藤忠明, 金高弘恭, 清水良央, 阿部利彦, 森仁, 森和美, 鈴木栄三郎, 高木敏行, 出江紳一

バイオメカニズム学術講演会予稿集　33回　93-94　2012/12
Publisher: バイオメカニズム学会
連続パルス磁場による末梢神経への磁気刺激に関する研究

森仁, 出江紳一, 高木敏行, 金高弘恭, 鈴木栄三郎, 森和美, 阿部利彦

バイオメカニズム学術講演会予稿集　33回　95-98　2012/12
Publisher: バイオメカニズム学会
Zeta potential of alumina powders with different crystalline phases in simulated body fluids

Masakazu Kawashita, Ayumi Kamitani, Toshiki Miyazaki, Naoko Matsui, Zhixia Li, Hiroyasu Kanetaka, Masami Hashimoto

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　32　(8)　2617-2622　2012/12

DOI： 10.1016/j.msec.2012.08.013 　

ISSN： 0928-4931

eISSN： 1873-0191
δ型アルミナのアルブミン吸着挙動

林純平, 川下将一, 宮崎敏樹, 橋本雅美, 金高弘恭

日本バイオマテリアル学会大会予稿集　シンポジウム2012　198-198　2012/11
Publisher: 日本バイオマテリアル学会
噴霧乾燥法による深部癌血管内放射線治療用リン酸イットリウム微小球の作製

中村梢, 川下将一, 宮崎敏樹, 金高弘恭

日本バイオマテリアル学会大会予稿集　シンポジウム2012　207-207　2012/11
Publisher: 日本バイオマテリアル学会
Sol-gel synthesis, characterization, and in vitro compatibility of iron nanoparticle-encapsulating silica microspheres for hyperthermia in cancer therapy International-journal

Zhixia Li, Masakazu Kawashita, Tada-aki Kudo, Hiroyasu Kanetaka

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　23　(10)　2461-2469　2012/10

DOI： 10.1007/s10856-012-4735-y 　

ISSN： 0957-4530

eISSN： 1573-4838
In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor International-journal

Zhixia Li, Koki Kawamura, Masakazu Kawashita, Tada-aki Kudo, Hiroyasu Kanetaka, Masahiro Hiraoka

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　100A　(10)　2537-2545　2012/10

DOI： 10.1002/jbm.a.34185 　

ISSN： 1549-3296

eISSN： 1552-4965
Dumマウスにおける骨格筋及び運動ニューロンの変性

藤田雅俊, 佐藤匡, 狩野充浩, 清水良央, 金高弘恭, 鈴木敏彦, 市川博之

Journal of Oral Biosciences Supplement　2012　107-107　2012/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
パルス電磁場刺激依存的な神経突起伸長誘導メカニズムの検討

工藤忠明, 清水良央, 金高弘恭

Journal of Oral Biosciences Supplement　2012　134-134　2012/09
Publisher: (一社)歯科基礎医学会
ISSN： 2187-2333

eISSN： 2187-9109
C-3-25 Multispectral Imaging utilizing photonic crystal wavelength filters

ITO Satoru, OHTERA Yasuo, KANETAKA Hiroyasu, YAMADA Hirohito

Proceedings of the Society Conference of IEICE　2012　(1)　142-142　2012/08/28
Publisher: The Institute of Electronics, Information and Communication Engineers
吸収性ハイドロキシアパタイトの3次元ブロック構築へ向けた医工学的検討

佐野有哉, 金高弘恭, 清水良央, 工藤忠明, 上高原理暢, 井奥洪二, 佐々木啓一

日本歯科医師会雑誌　65　(5)　639-639　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
音叉振動式粘度計を用いた口腔湿潤材の粘度評価

洪光, 王維奇, 金高弘恭, 佐々木啓一

日本歯科医師会雑誌　65　(5)　645-645　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
低温アルカリ処理を応用した歯科用インプラントの生体内リカバリーシステムの開発

金高弘恭, 清水良央, 工藤忠明, 井上全, 松井真子, 川下将一, 佐々木啓一

日本歯科医師会雑誌　65　(5)　677-677　2012/08
Publisher: (公社)日本歯科医師会
ISSN： 0047-1763
生体内挙動でみる生体吸収性ハイドロキシアパタイトの分解特性

石橋卓大, 佐野有哉, 清水良央, 金高弘恭, 井奥洪二

日本口腔インプラント学会誌　25　(2)　333-333　2012/06
Publisher: (公社)日本口腔インプラント学会
ISSN： 0914-6695

eISSN： 2187-9117
形状記憶合金―最新の材料の開発と応用の発展レントゲン造影性の良い生体用形状記憶合金の開発

細田秀樹, 稲邑朋也, 田原正樹, 後藤研滋, 金高弘恭

金属　82　(6)　480-486　2012/06/01

ISSN： 0368-6337
東北大学病院におけるチーム医療の現状歯科治療と言語療法について

中條哲, 徳川宜靖, 横山奈加子, 磯野信策, 金高弘恭, 幸地省子, 五十嵐薫

日本口蓋裂学会雑誌　37　(2)　175-175　2012/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
後肢筋萎縮を伴うDegenerating muscle(dmu) mouseの骨成長に関する形態計測学的研究

清水良央, 金高弘恭, 佐藤匡, 市川博之, 熊本裕行

日本病理学会会誌　101　(1)　343-343　2012/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
The effect of sericin powder on the absorption and solubility of trial tissue conditioner

HONG G, DILINUER MS, WANG WQ, KANETAKA H, SASAKI K

The journal of the Japanese Society for Dental Materials and Devices　31　(2)　175-175　2012/03
Publisher: 一般社団法人日本歯科理工学会
ISSN： 1884-4421
COMPARISON OF ADSORPTION BEHAVIOR OF BOVINE SERUM ALBUMIN AND OSTEOPONTIN ON HYDROXYAPATITE AND ALUMINA

Jumpei Hayashi, Masakazu Kawashita, Toshiki Miyazaki, Masanobu Kamitakahara, Koji Ioku, Hiroyasu Kanetaka

Phosphorus Research Bulletin　26　23-28　2012
Publisher: Japanese Association of Inorganic Phosphorus Chemistry
DOI： 10.3363/prb.26.23 　

ISSN： 0918-4783

eISSN： 1882-2363
Effects of the small molecule dorsomorphin on intracellular signaling

Tada-Aki Kudo, Hiroyasu Kanetaka, Kazutoshi Mizuno, Yasuhiro Ryu, Ye Zhang, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi

Interface Oral Health Science 2011　131-133　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_31 　
Downregulation of dullard expression enhances BMP-dependent neuritogenesis in PC12 cells

Ye Zhang, Tada Aki Kudo, Yoshinaka Shimizu, Mitsuhiro Kano, Yuya Sano, Hiroyasu Kanetaka

Interface Oral Health Science 2011　167-169　2012/01/01
Publisher: Springer Japan
DOI： 10.1007/978-4-431-54070-0_44 　
Martensite variant reorientation of NiMnGa/silicone composites containing polystyrene foam particles

Yui Watanabe, Motoki Okuno, Yoshinaka Shimizu, Hiroyasu Kanetaka, Tomonari Inamura, Hideki Hosoda

Advanced Materials Research　409　645-650　2012

DOI： 10.4028/www.scientific.net/AMR.409.645 　

ISSN： 1022-6680
水酸アパタイトおよびα型アルミナのアルブミンならびにオステオポンチン吸着挙動

林純平, 李志霞, 川下将一, 上高原理暢, 井奥洪二, 宮崎敏樹, 金高弘恭

日本バイオマテリアル学会大会予稿集　33回　81-81　2011/11
Publisher: 日本バイオマテリアル学会
噴霧乾燥法による深部癌血管内放射線治療用微小球の作製

中村梢, 李志霞, 川下将一, 宮崎敏樹, 金高弘恭

日本バイオマテリアル学会大会予稿集　33回　465-465　2011/11
Publisher: 日本バイオマテリアル学会
焼結および水熱処理を施したハイドロキシアパタイトの生体内分解特性に関する形態計測学的研究

清水良央, 佐野有哉, 石橋卓大, 工藤忠明, 金高弘恭, 井奥洪二, 市川博之, 熊本裕行

日本バイオマテリアル学会大会予稿集　33回　468-468　2011/11
Publisher: 日本バイオマテリアル学会
生体活性型インプラント表面の生体内再活性化処理に関する基礎的検討

井上全, 金高弘恭, 清水良央, 工藤忠明, 洪光, 松井真子, 川下将一, 佐々木啓一

日本バイオマテリアル学会大会予稿集　33回　500-500　2011/11
Publisher: 日本バイオマテリアル学会
Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway. International-journal

Tada-aki Kudo, Hiroyasu Kanetaka, Kazutoshi Mizuno, Yasuhiro Ryu, Yoshiyuki Miyamoto, Shoko Nunome, Ye Zhang, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi

Genes to cells : devoted to molecular & cellular mechanisms　16　(11)　1121-32　2011/11

DOI： 10.1111/j.1365-2443.2011.01556.x 　

ISSN： 1356-9597
Synostosis of the joint between the body and greater cornu of the human hyoid bone. International-journal

Hiroyasu Kanetaka, Yoshinaka Shimizu, Mitsuhiro Kano, Masayoshi Kikuchi

Clinical anatomy (New York, N.Y.)　24　(7)　837-42　2011/10

DOI： 10.1002/ca.21183 　

ISSN： 0897-3806
Development of motion capture system using magnetic ribbon type marker

MORI O, NAKANO H, AKAMA F, YABUKAMI S, OZAWA T, ISHII O, HASHI S, KANETAKA H

電気学会研究会資料. MAG, マグネティックス研究会　2011　(52)　51-55　2011/09/19
DorsomorphinによるPKA経路とERK経路を介したPC12細胞神経突起形成誘導

工藤忠明, 金高弘恭, 清水良央, 布目祥子, 宮本祥行, 林治秀

Journal of Oral Biosciences　53　(Suppl.)　123-123　2011/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
DorsomorphinはMEK-ERKシグナル経路を介してPC12細胞神経突起伸長を刺激する(Dorsomorphin stimulates neurite outgrowth via the MEK-ERK signaling pathway in PC12 cells)

工藤忠明, 金高弘恭, 水野二寿, 竜康弘, 張曄, 狩野光浩, 清水良央, 林治秀

日本細胞生物学会大会講演要旨集　63回　160-160　2011/05
Publisher: (一社)日本細胞生物学会
高齢ラットにおける骨と腱、筋、筋膜結合部(エンテーシス)の形態学的変化

清水良央, 金高弘恭, 市川博之, 熊本裕行

Clinical Calcium　21　(5)　759-760　2011/04
Publisher: (株)医薬ジャーナル社
ISSN： 0917-5857
口唇裂・口蓋裂児で直接母乳は可能か事例を通して

幸地省子, 篠原ひとみ, 金高弘恭

日本口蓋裂学会雑誌　36　(2)　97-97　2011/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
Le FortI型骨切りを行って咬合形成した左側完全口唇口蓋裂女子症例顎裂骨移植術後感染例

幸地省子, 徳川宜靖, 中條哲, 今井啓道, 館正弘, 金高弘恭

日本口蓋裂学会雑誌　36　(2)　137-137　2011/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
口唇裂初回手術前から咬合管理を行った左側口唇口蓋裂非抜歯女子症例

幸地省子, 金高弘恭, 中條哲, 徳川宜靖, 今井啓道, 館正弘

日本口蓋裂学会雑誌　36　(2)　142-142　2011/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
Degenerating muscle(dmu)mouseの骨成長に関する解剖学および病理学的検討

清水良央, 金高弘恭, 市川博之, 熊本裕行

日本病理学会会誌　100　(1)　370-370　2011/03
Publisher: (一社)日本病理学会
ISSN： 0300-9181
Position Sensing System of Nasogastric Tube Using Long LC Resonated Marker

Sato R, Hayasaka Y, Yabukami S, Ozawa T, Kanetaka H, Hashi S

Journal of the Magnetics Society of Japan　35　(2)　67-71　2011
Publisher: 公益社団法人日本磁気学会
DOI： 10.3379/msjmag.1101R009 　

ISSN： 1882-2924

More details Close

&nbsp;&nbsp;A position-detecting system made up of a nasogastric tube using a wireless LC resonated magnetic marker has been developed. The marker, consisting of an inductor and a capacitor without battery or electric wires, was installed inside a commercial nasogastric tube. A positioning accuracy within 7.1mm was obtained when the marker inside the tube was parallel translation to 100mm. The marker inside the tube was roughly tracked in the esophagus and trachea of a human model.
ヒト喉頭蓋軟骨の加齢変化に関する組織化学的およびX線学的研究

金高弘恭, 清水良央, 狩野充浩

日本摂食・嚥下リハビリテーション学会雑誌　14　(3)　436-436　2010/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
骨補填材移植を行った骨欠損部の血流回復と血管再生

清水良央, 金高弘恭, 佐野有哉, 張曄, 狩野充浩, 工藤忠明, 井奥洪二, 市川博之, 熊本裕行

日本バイオマテリアル学会大会予稿集　32回　254-254　2010/11
Publisher: 日本バイオマテリアル学会
生体吸収性ハイドロキシアパタイトの骨形成評価に関する研究

金高弘恭, 井奥洪二, 佐野有哉, 張曄, 狩野充浩, 工藤忠明, 清水良央, 佐々木啓一

日本バイオマテリアル学会大会予稿集　32回　369-369　2010/11
Publisher: 日本バイオマテリアル学会
Ti‐Mo‐Al生体用形状記憶合金の機械的性質に及ぼす多段時効の影響

細田秀樹, 谷口誠, 稲邑朋也, 金高弘恭, 宮崎修一

日本機械学会M&M材料力学カンファレンス(CD-ROM)　2010　ROMBUNNO.911　2010/10
Investigating bone morphogenetic protein (BMP) signaling in a newly established human cell line expressing BMP receptor type II.

Tada-aki Kudo, Hiroyasu Kanetaka, Akira Watanabe, Ayako Okumoto, Masanobu Asano, Ye Zhang, Fei Zhao, Mitsuhiro Kano, Yoshinaka Shimizu, Shinri Tamura, Haruhide Hayashi

The Tohoku journal of experimental medicine　222　(2)　121-9　2010/10

DOI： 10.1620/tjem.222.121 　

ISSN： 0040-8727

eISSN： 1349-3329
MPC polymer regulates fibrous tissue formation by modulating cell adhesion to the biomaterial surface.

Ye Zhang, Hiroyasu Kanetaka, Yuya Sano, Mitsuhiro Kano, Tada-aki Kudo, Yoshinaka Shimizu

Dental materials journal　29　(5)　518-28　2010/10

DOI： 10.4012/dmj.2009-138 　

ISSN： 0287-4547

eISSN： 1881-1361
Investigating Bone Morphogenetic Protein (BMP) Signaling in a Newly Established Human Cell Line Expressing BMP Receptor Type II

Tada-aki Kudo, Hiroyasu Kanetaka, Akira Watanabe, Ayako Okumoto, Masanobu Asano, Ye Zhang, Fei Zhao, Mitsuhiro Kano, Yoshinaka Shimizu, Shinri Tamura, Haruhide Hayashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　222　(2)　121-129　2010/10

DOI： 10.1620/tjem.222.121 　

ISSN： 0040-8727

eISSN： 1349-3329
Position sensing system of nasogastric tube using long LC resonated maker

SATO R, YABUKAMI S, OZAWA T, KANETAKA H, HASHI S

電気学会研究会資料. MAG, マグネティックス研究会　2010　(106)　19-22　2010/09/21
BMPシグナルによるSPATA5遺伝子発現調節機構の解析

工藤忠明, 金高弘恭, 清水良央, 林治秀

Journal of Oral Biosciences　52　(Suppl)　159-159　2010/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
多孔性水熱処理β-TCPの骨再生への応用

礒邊貴子, 佐野有哉, 清水良央, 張曄, 狩野充浩, 金高弘恭, 井奥洪二, 市川博之

Journal of Oral Biosciences　52　(Suppl)　160-160　2010/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
ラット頭蓋冠骨欠損モデルにおける欠損部血流の変化と血管形成

清水良央, 金高弘恭, 張曄, 佐野有哉, 狩野充浩, 佐藤工, 工藤忠明, 熊本裕行

Journal of Oral Biosciences　52　(Suppl)　160-160　2010/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
MPC polymer regulates fibrous tissue formation by modulating cell adhesion to the biomaterial surface

Ye Zhang, Hiroyasu Kanetaka, Yuya Sano, Mitsuhiro Kano, Tada-aki Kudo, Yoshinaka Shimizu

DENTAL MATERIALS JOURNAL　29　(5)　518-528　2010/09

DOI： 10.4012/dmj.2009-138 　

ISSN： 0287-4547
生体吸収性ハイドロキシアパタイト顆粒の作製および骨形成評価

金高弘恭, 井奥洪二, 佐野有哉, 清水良央, 佐々木啓一

日本口腔インプラント学会誌　23　(特別号)　274-274　2010/08
Publisher: (公社)日本口腔インプラント学会
ISSN： 0914-6695

eISSN： 2187-9117
計量心理学的手法を用いた顎顔面領域の瘢痕・補綴に対するセラピーメーキャップの臨床的有用性評価に関する研究

金高弘恭, 幸地省子, 小山重人, 足立智昭, 真覚健, 阿部恒之, 鈴鴨よしみ, 青木昭子, 提橋義則, 稲川弘, 佐々木啓一

日本歯科医学会誌　29　119-119　2010/03
Publisher: 日本歯科医学会
ISSN： 0286-164X
Wireless magnetic motion capture system for medical use

Hiroyasu Kanetaka, Shin Yabukami, Syuichiro Hashi, Ken-Ichi Arai

INTERFACE ORAL HEALTH SCIENCE 2009　329-331　2010

DOI： 10.1007/978-4-431-99644-6_96 　
Medical application of magnesium and its alloys as degradable biomaterials

Yoshinaka Shimizu, Akiko Yamamoto, Toshiji Mukai, Yoko Shirai, Mitsuhiro Kano, Tadaaki Kudo, Hiroyasu Kanetaka, Masayoshi Kikuchi

INTERFACE ORAL HEALTH SCIENCE 2009　318-+　2010

DOI： 10.1007/978-4-431-99644-6_93 　
Regulation of bone morphogenetic protein-mediated signaling by tumor necrosis factor-alpha

Keisuke Okayama, Tada-aki Kudo, Yoshinaka Shimizu, Ye Zhang, Fei Zhao, Mitsuhiro Kano, Hiroyasu Kanetaka, Keiichi Sasaki

INTERFACE ORAL HEALTH SCIENCE 2009　202-204　2010

DOI： 10.1007/978-4-431-99644-6_48 　
Physiological role of type II bone morphogenetic protein receptor and its interacting molecules in bone morphogenetic protein signaling

Tada-aki Kudo, Akira Watanabe, Masanobu Asano, Ye Zhang, Fei Zhao, Mitsuhiro Kano, Yoshinaka Shimizu, Hiroyasu Kanetaka, Shinri Tamura, Haruhide Hayashi

INTERFACE ORAL HEALTH SCIENCE 2009　193-195　2010

DOI： 10.1007/978-4-431-99644-6_45 　
Role of the protein serine/threonine phosphatase dullard in cell differentiation

Fei Zhao, Tada-aki Kudo, Ye Zhang, Mitsuhiro Kano, Shinri Tamura, Yoshinaka Shimizu, Hiroyasu Kanetaka, Haruhide Hayashi

INTERFACE ORAL HEALTH SCIENCE 2009　196-198　2010

DOI： 10.1007/978-4-431-99644-6_46 　
The role of extracellular signal-regulated kinase 5 signaling pathway in neurons

Ye Zhang, Tada-aki Kudo, Yunchia Ku, Fei Zhao, Mitsuhiro Kano, Yoshinaka Shimizu, Haruhide Hayashi, Taizo Hamada, Hiroyasu Kanetaka

INTERFACE ORAL HEALTH SCIENCE 2009　199-201　2010

DOI： 10.1007/978-4-431-99644-6_47 　
Self-Accommodation Morphology in Ti-Nb-Al Shape Memory Alloy

Tomonari Inamura, Hideki Hosoda, Hiroyasu Kanetaka, Hee Young Kim, Shuichi Miyazaki

PRICM 7, PTS 1-3　654-656　2154-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2154 　

ISSN： 0255-5476
Effect of Nitrogen Addition on Mechanical Property of Ti-Cr-Sn Alloy

Yuichi Nakahira, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2126-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2126 　

ISSN： 0255-5476
Phase Constituents of Ti-Cr-Au and Ti-Cr-Au-Zr Alloy Systems

Yuri Shinohara, Takuya Ishigaki, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2122-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2122 　

ISSN： 0255-5476
Phase Constitution and Mechanical Properties of Ti-(Cr, Mn)-Sn Biomedical Alloys

Yasuhiro Kusano, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2118-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2118 　

ISSN： 0255-5476
Effect of Aging on Mechanical Properties of Ti-Mo-Al Biomedical Shape Memory Alloy

Hideki Hosoda, Makoto Taniguchi, Tomonari Inamura, Hiroyasu Kanetaka, Shuichi Miyazaki

PRICM 7, PTS 1-3　654-656　2150-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2150 　

ISSN： 0255-5476
Compression Behavior and Texture Development of Polymer Matrix Composites Based on NiMnGa Ferromagnetic Shape Memory Alloy Particles

Motoki Okuno, Tomonari Inamura, Hiroyasu Kanetaka, Hideki Hosoda

PRICM 7, PTS 1-3　654-656　2103-+　2010

DOI： 10.4028/www.scientific.net/MSF.654-656.2103 　

ISSN： 0255-5476
Coils configuration and detection accuracy of position sensing system

HASHI Shuichiro, KANETAKA Hiroyasu, ISHIYAMA Kazushi, YABUKAMI Shin, ARAI Ken Ichi

電気学会研究会資料. MAG, マグネティックス研究会　2009　(207)　1-4　2009/12/16
Jaw tracking system using resonated wireless markers

YABUKAMI S, KANETAKA H, HASHI S, ARAI K. I

電気学会研究会資料. MAG, マグネティックス研究会　2009　(86)　1-5　2009/09/25
ヒト内舌筋の加齢変化

狩野充浩, 清水良央, 工藤忠明, 金高弘恭

日本老年歯科医学会総会・学術大会プログラム・抄録集　20回　149-149　2009/06
Publisher: (一社)日本老年歯科医学会
Flp-In/T-RExシステムを応用したII型骨形成因子(BMP)受容体の新しい機能に関する網羅的解析

工藤忠明, 清水良央, 張曄, 岡山啓昌, 趙菲, 狩野充浩, 田村眞理, 金高弘恭, 林治秀

東北大学歯学雑誌　28　(1)　27-28　2009/06
Publisher: 東北大学歯学会
ISSN： 0287-3915
生体吸収性マグネシウム合金の生体内動態に関する研究

清水良央, 山本玲子, 向井敏司, 白井暢子, 狩野充浩, 岡山啓昌, 工藤忠明, 金高弘恭, 菊地正嘉

Journal of Oral Biosciences　50　(Suppl.)　125-125　2008/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
プロトン関連糖輸送体-Aの制御因子としてのc-Jun N末端キナーゼの可能性(c-Jun N-terminal Kinase is a possible regulator of proton-associated sugar transporter-A)

工藤忠明, 清水良央, 金高弘恭, 林治秀

Journal of Oral Biosciences　50　(Suppl.)　161-161　2008/09
Publisher: (一社)歯科基礎医学会
ISSN： 1349-0079

eISSN： 1880-3865
ヒト喉頭蓋における喉頭腺の加齢変化

狩野充浩, 清水良央, 金高弘恭, 工藤忠明, 菊地正嘉

老年歯科医学　23　(2)　244-245　2008/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866

eISSN： 1884-7323
An Improvement of Position Accuracy for a Wireless Magnetic Marker Tracking System

YABUKAMI S, HASHI S, KANETAKA H, ARAI K. I

電気学会研究会資料. MAG, マグネティックス研究会　2008　(84)　29-33　2008/07/31
JNKによるproton-associated sugar transporter-Aの制御機構(Regulatory mechanism of proton-associated sugar transporter-A by JNK)

工藤忠明, 清水良央, 金高弘恭, 田村眞理, 林治秀

日本細胞生物学会大会講演要旨集　60回　129-129　2008/06
Publisher: (一社)日本細胞生物学会
チューイングガム法による口唇裂口蓋裂患者の咀嚼能力の経年変化に関する研究

幸地省子, 金高弘恭, 尾崎史浩

日本口蓋裂学会雑誌　33　(2)　115-115　2008/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
摂食機能評価のための新しい検査用ゼリーの開発と臨床応用の試み

金高弘恭, 幸地省子, 新井映子, 中條哲

日本口蓋裂学会雑誌　33　(2)　116-116　2008/04
Publisher: (一社)日本口蓋裂学会
ISSN： 0386-5185

eISSN： 2186-5701
ヒト喉頭蓋軟骨における折り曲げ応力の検討

狩野充浩, 清水良央, 小野寺健, 金高弘恭, 冨塚亮, 菊地正嘉

老年歯科医学　22　(2)　177-178　2007/09
Publisher: (一社)日本老年歯科医学会
ISSN： 0914-3866

eISSN： 1884-7323
Orthodontic tooth movement in rats using Ni-free Ti-based shape memory alloy wire

Hiroyasu Kanetaka, Yoshinaka Shimizu, Hideki Hosoda, Ryo Tomizuka, Akihiro Suzuki, Shachiko Urayama, Tomonari Inamura, Shuichi Miyazaki, Teruko Takano-Yamamoto

MATERIALS TRANSACTIONS　48　(3)　367-372　2007/03

DOI： 10.2320/matertrans.48.367 　

ISSN： 1345-9678

eISSN： 1347-5320
より豊かな生活に貢献する医療技術に関する研究生体内モーションキャプチャシステムを応用した非侵襲的な咀嚼・嚥下機能測定装置の開発

金高弘恭, 藪上信, 荒井賢一

医科学応用研究財団研究報告　24　45-48　2007/02
Publisher: (公財)鈴木謙三記念医科学応用研究財団
ISSN： 0914-5117

eISSN： 2185-2561
超精密鏡面加工による純チタン製口腔内用ミラーの開発

金高弘恭, 鈴木章裕, 冨塚亮, 浦山佐知子, 五十嵐薫, 山本照子

日本矯正歯科学会大会プログラム・抄録集　65回　222-222　2006/09
Publisher: (公社)日本矯正歯科学会
新しいNiフリー形状記憶・超弾性合金構成金属元素のラット臓器への蓄積

鈴木章裕, 金高弘恭, 亀尾聡美, 冨塚亮, 浦山佐知子, 清水良央, 細田秀樹, 五十嵐薫, 山本照子

日本矯正歯科学会大会プログラム・抄録集　65回　224-224　2006/09
Publisher: (公社)日本矯正歯科学会
小さな初期加重から漸増する力を用いた矯正学的歯の移動における組織学的評価

冨塚亮, 金高弘恭, 鈴木章裕, 浦山佐知子, 清水良央, 五十嵐薫, 山本照子

日本矯正歯科学会大会プログラム・抄録集　65回　245-245　2006/09
Publisher: (公社)日本矯正歯科学会
埋入SMAワイヤーによる顎整形力負荷がラット矢状縫合に及ぼす影響

浦山佐知子, 金高弘恭, 冨塚亮, 鈴木章裕, 清水良央, 細田秀樹, 山本照子, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　65回　246-246　2006/09
Publisher: (公社)日本矯正歯科学会
上下に磁界センサを分離した測定システムによる6自由度顎運動測定

金高弘恭, 薮上信, 冨塚亮, 三谷英夫, 荒井賢一

日本顎関節学会雑誌　18　(1)　76-76　2006/04
Publisher: (一社)日本顎関節学会
ISSN： 0915-3004

eISSN： 1884-4308
ヒト舌骨の加齢変化に関する形態計測学的および組織学的検討

金高弘恭, 清水良央, 冨塚亮, 鈴木章裕, 菊地正嘉, 五十嵐薫

日本咀嚼学会雑誌　15　(2)　103-104　2005/11
Publisher: (NPO)日本咀嚼学会
ISSN： 0917-8090

eISSN： 1884-4448
Orthodontic tooth movement in rats using Ni-free Ti-base SMA wire

Hiroyasu Kanetaka, Yoshinaka Shimizu, Hideki Hosoda, Ryo Tomizuka, Akihiro Suzuki, Shuichi Miyazaki, Kaoru Igarashi

International Congress Series　1284　310-311　2005/09

DOI： 10.1016/j.ics.2005.06.013 　

ISSN： 0531-5131
Orthodontic tooth movement using the attractive force of rare earth magnets in rats

Ryo Tomizuka, Hiroyasu Kanetaka, Yoshinaka Shimizu, Akihiro Suzuki, Kaoru Igarashi

International Congress Series　1284　322-323　2005/09

DOI： 10.1016/j.ics.2005.06.016 　

ISSN： 0531-5131
Outcome of orthodontic treatment combined with MPA and secondary alveolar bone grafting in UCLP patients

Shoko Kochi, Hiroyasu Kanetaka, Hiroki Kita, Takayoshi Daimaruya

International Congress Series　1284　79-80　2005/09

DOI： 10.1016/j.ics.2005.06.052 　

ISSN： 0531-5131
A Development of a Position Sensing System Using Planar Spiral Coils

KOUNO Takeshi, YABUKAMI Shin, AGATSUMA Shigeto, ARAI Ken Ichi, KANETAKA Hiroyasu

電気学会研究会資料. MAG, マグネティックス研究会　2005　(50)　7-11　2005/07/14
複数磁気マーカを利用した6自由度顎運動測定装置の開発

金高弘恭, 薮上信, 荒井賢一

日本顎関節学会雑誌　17　(1)　91-91　2005/04
Publisher: (一社)日本顎関節学会
ISSN： 0915-3004

eISSN： 1884-4308
Age-related morphological changes in the human hyoid bone. International-journal

Yoshinaka Shimizu, Hiroyasu Kanetaka, Yeon-Hwan Kim, Keisuke Okayama, Mitsuhiro Kano, Masayoshi Kikuchi

Cells, tissues, organs　180　(3)　185-92　2005

DOI： 10.1159/000088247 　

ISSN： 1422-6405
磁気式モーションキャプチャシステムを応用した口腔機能改善支援システムの構築

金高弘恭, 薮上信, 荒井賢一, 五十嵐薫

日本摂食・嚥下リハビリテーション学会雑誌　8　(2)　225-225　2004/12
Publisher: (一社)日本摂食嚥下リハビリテーション学会
ISSN： 1343-8441

eISSN： 2434-2254
学童期の重度う蝕に起因した咬合崩壊を伴う成人女子症例に対してスケレタル・アンカレッジ・システムおよびデンタル・インプラントを用いた包括歯科治療

馬渕量平, 河内満彦, 菅原準二, 金高弘恭, 西村真, 長坂浩

東北矯正歯科学会雑誌　12　(1)　107-108　2004/12
Publisher: 東北矯正歯科学会
ISSN： 1340-2668
上顎前方成長誘導および顎裂骨移植術を行った片側性完全口唇口蓋裂女子症例についての考察

幸地省子, 金高弘恭, 友寄裕子, 川村仁

東北矯正歯科学会雑誌　12　(1)　108-108　2004/12
Publisher: 東北矯正歯科学会
ISSN： 1340-2668
ニッケルフリー形状記憶合金の超弾性特性を利用した矯正学的歯の移動に関する研究

金高弘恭, 清水良央, 細田秀樹, 鈴木章裕, 五十嵐薫, 三谷英夫

日本矯正歯科学会大会プログラム・抄録集　63回　215-215　2004/11
Publisher: (公社)日本矯正歯科学会
希土類小型永久磁石の吸引力を利用した矯正学的歯の移動に関する研究

冨塚亮, 金高弘恭, 清水良央, 五十嵐薫

日本矯正歯科学会大会プログラム・抄録集　63回　243-243　2004/11
Publisher: (公社)日本矯正歯科学会
2個の永久磁石を用いた高精度顎運動計測システムの試作

薮上信二, 金高弘恭, 荒井賢一, 三谷英夫

日本矯正歯科学会大会プログラム・抄録集　63回　278-278　2004/11
Publisher: (公社)日本矯正歯科学会
上顎前方成長誘導および顎裂骨移植術を行った片側性完全口唇口蓋裂女子3症例についての考察

幸地省子, 金高弘恭, 斉藤修司, 友寄裕子, 渡辺和宏

日本矯正歯科学会大会プログラム・抄録集　63回　306-306　2004/11
Publisher: (公社)日本矯正歯科学会
磁気式モーションキャプチャシステムを応用した6自由度顎運動測定装置の開発

金高弘恭, 薮上信, 荒井賢一, 三谷英夫

日本矯正歯科学会大会プログラム・抄録集　63回　316-316　2004/11
Publisher: (公社)日本矯正歯科学会
Development of jaw tracking system using flat spiral coil

KOHNO T, YABUKAMI S, KANETAKA H, ARAI K. I, MITANI H

日本応用磁気学会学術講演概要集 = Digest of ... annual conference on magnetics in Japan　28　375-375　2004/09/21
Magnetic Jaw-Tracking System Available with Six Degrees of Freedom

YABUKAMI S, ARAI K, KANETAKA H, TSUJI S, ARAI K. I

Journal of Magnetics Society of Japan　28　(5)　711-717　2004/05/01
Publisher: 日本応用磁気学会
DOI： 10.3379/jmsjmag.28.711 　

ISSN： 0285-0192

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We developed a jaw-tracking system consisting of two magnets and biaxial fluxgate sensors. One magnet is fastened to a tooth in the bottom jaw of the subject and another is fastened to the subject's forehead. The system can naturally detect movement of the jaw as a rigid body. We fabricated sensor arrays with separate upper and lower parts in order to obtain good position accuracy. Positional accuracy to within 0.1 mm was achieved as a rigid body using a jaw model. Six degrees of freedom and 100 Hz sensing cycles were achieved using one rigid marker (composed of two magnets), and achieved position accuracy to within 0.3 mm.
Development of jaw tracking system using two magnets

YABUKAMI S, ARAI K, KANETAKA H, TSUJI S, ARAI K. I

日本応用磁気学会学術講演概要集 = Digest of ... annual conference on magnetics in Japan　27　466-466　2003/09/01

ISSN： 1340-8100
18年経過中のブレード・ベント骨内インプラント下顎片側性遊離端補綴の1症例

伊藤秀美, 安藤申直, 佐々木具文, 遠藤英昭, 金高弘恭, 山崎正隆

日本口腔インプラント学会誌　16　(2)　311-311　2003/06
Publisher: (公社)日本口腔インプラント学会
ISSN： 0914-6695

eISSN： 2187-9117
Error Analysis of a Jaw-Tracking System Using Two Magnets

YABUKAMI S, ARAI K, KANETAKA H, TSUJI S, ARAI K. I, MITANI H

Journal of Magnetics Society of Japan　27　(6)　765-770　2003/06/01
Publisher: 日本応用磁気学会
DOI： 10.3379/jmsjmag.27.765 　

ISSN： 0285-0192

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We developed a new system to capture jaw movement. It consists of two magnets and biaxial fluxgate sensors. A magnet is fixed to a tooth in the bottom jaw of the subject and another is fixed to the subject's forehead. The system can naturally detect movement of the jaw as a rigid body, because it does not require such attachments as a clutch inside the mouth or a magnetic field sensor array in contact with the head. In this paper, we investigate five error sources of the jaw-tracking system, using a jaw model, and report the achievement of a positional accuracy of 1.5 mm and an axial accuracy of 2 degrees. Positional accuracy within 2 mm is achieved as a rigid body.
A Motion Capturing System of Jaw Movement Using Two Magnets

YABUKAMI S, ARAI K, KANETAKA H, TSUJI S, ARAI K. I, MITANI H

電気学会研究会資料. MAG, マグネティックス研究会　2002　(107)　37-42　2002/10/09
A new tracking system of jaw movement using two magnets

S Yabukami, H Kanetaki, N Tsuji, A Itagaki, M Yamaguchi, KI Arai, H Mitani

IEEE TRANSACTIONS ON MAGNETICS　38　(5)　3315-3317　2002/09

DOI： 10.1109/TMAG.2002.802301 　

ISSN： 0018-9464
Jaw tracking system using thin film sensors

YABUKAMI S, ARAI K, ARAI K. I, KANETAKA H, MITANI H, TSUJI N

日本応用磁気学会学術講演概要集 = Digest of ... annual conference on magnetics in Japan　26　355-355　2002/09/01

ISSN： 1340-8100
The influence of gnathic dysfunction caused by TMJ sounds on masticatory efficiency : Evaluation by means of ATP absorbance and chewing gum methods

KANETAKA Hiroyasu, MITANI Hideo

TMJ : journal of Japanese Society for Temporomandibular Joint : 日本顎関節学会雑誌　14　(1)　25-30　2002/04/20

ISSN： 0915-3004
Capturing Jaw Movement Using Two-magnet System

YABUKAMI S, KANETAKA H, TSUJI N, ITAGAKI A, YAMAGUCHI M, ARAI K, MITANI H

Journal of Magnetics Society of Japan　26　(4)　616-620　2002/04/01
Publisher: 日本応用磁気学会
DOI： 10.3379/jmsjmag.26.616 　

ISSN： 0285-0192

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We developed a new motion-capture system for jaw movement using two magnets and two-axial fluxgate sensors. Two magnets are fixed to a tooth in the lower jaw and to the forehead. The system can naturally detect the jaw movement as a rigid body because the system has no need for attachments such as a clutch inside the mouth or a magnetic field sensor array in contact with the head.
Development of a new jaw movement analyzer by means of motion capture system of magnetic markers

H Kanetaka, S Yabukami, M Kawauchi, K Arai, H Mitani

JOURNAL OF DENTAL RESEARCH　81　A341-A341　2002/03

ISSN： 0022-0345
複数磁気マーカを用いた新型顎運動測定装置の開発

金高弘恭, 薮上信, 河内満彦, 荒井賢一, 三谷英夫

日本咀嚼学会雑誌　11　(2)　166-167　2002/03
Publisher: (NPO)日本咀嚼学会
ISSN： 0917-8090
Relationship between masticatory efficiency and occlusal contact area as well as occlussal force in normal occulusion : By means of ATP absorbance method and chewing gum method

KANETAKA Hiroyasu, MITANI Hideo

Orthod Waves-Jpn Ed　61　(1)　14-21　2002/02/25
Publisher: 日本矯正歯科学会
ISSN： 1344-0241

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The aims of this study were to evaluate masticatory efficiencies by means of ATP absorbance method and chewing gum method, and to elucidate relationship between masticatory efficiency and occlusal contact area as well as occlussal force in normal occlusion. Materials consisted of 30 individuals (15 males and 15 females) chosen from approximately 5, 000 young adult population ; all represented a normal occlusion. The results of this study were as follows : 1. Mean vales of masticatory efficiency using ATP absorbance method, masticatory efficiency using chewing gum method, occlusal contact area and occlussal force were 1.74±0.35 Abs., 26.9±4.40 mg/s, 26.3±6.0 mm^2, 1164.6±295.0 N, respectively, for male, and 1.50±0.42 Abs., 25.0±2.99 mg/s, 22.6±5.5 mm^2, 939.6±217.3 N for female. 2. There was sex difference only in the occlussal force.3. Masticatory efficiency by means of ATP absorbance method was not significantly correlated with masticatory efficiency by means of chewing gum method.4. Masticatory efficiency by means of ATP absorbance method was significantly correlated with both occlusal contact area and occlussal force.5. Masticatory efficiency by means of chewing gum method was not significantly correlated with either occlusal contact and occlussal force.
The influence of gnathic dysfunction caused by TMJ sounds on masticatory efficiency

KANETAKA Hiroyasu, MITANI Hideo

Journal of the Japanese Society for the Temporomandibular Joint　14　(1)　25-30　2002
Publisher: The Japanese Society for Temporomandibular Joint
ISSN： 0915-3004

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Masticatory is a very important function in our daily lives. However, it is said to be influenced by TMD in several ways. The purpose of this study was to clarify the influence of gnathic dysfunction caused by TMJ sounds on masticatory function. Subjects consisted of 40 individuals (20 males and 20 females) chosen under strict conditions from approximately 5, 000 young adults; all represented a normal occlusion. They were divided into two groups. The dysfunction group consisted of 10 subjects (5 males and 5 females) who had TMJ sounds, and the control group consisted of 30 subjects (15 males and 15 females) who had no gnathic dysfunction. It was confirmed that there was morphologically no significant difference between the two groups in rentgenocephalometrics measurements and occlusal contact area. We measured masticatory efficiency by means of ATP absorbance and chewing gum methods, which were simple and quick. This way masticatory function can be totally evaluated. The results of this study are as follows: 1. There was no significant difference between the two groups in masticatory efficiency by means of ATP absorbance method. 2. In masticatory efficiency by means of chewing gum method, the dysfunction group was significantly lower than the control group. The results suggest that gnathic dysfunction caused by TMJ sounds influences the masticatory function.
Capturing Jaw Movement Using Two-Magnet System.

Yabukami S, Kanetaka H, Tsuji N, Itagaki A, Yamaguchi M, Arai K. I, Mitani H

Journal of the Magnetics Society of Japan　26　(4)　616-620　2002
Publisher: The Magnetics Society of Japan
DOI： 10.3379/jmsjmag.26.616 　

ISSN： 0285-0192

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We developed a new motion-capture system for jaw movement using two magnets and two-axial fluxgate sensors. Two magnets are fixed to a tooth in the lower jaw and to the forehead. The system can naturally detect the jaw movement as a rigid body because the system has no need for attachments such as a clutch inside the mouth or a magnetic field sensor array in contact with the head.
A new tracking system of jaw movement using two magnets

S. Yabukami, H. Kanetaka, N. Tsuji, A. Itagaki, M. Yamaguchi, K. I. Arai, H. Mitani

INTERMAG Europe 2002 - IEEE International Magnetics Conference　2002
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/INTMAG.2002.1001389 　
A new tracking system of jaw movement using two magnets

S. Yabukami, H. Kanetaka, N. Tsuji, A. Itagaki, M. Yamaguchi, K. I. Arai, H. Mitani

INTERMAG Europe 2002 - IEEE International Magnetics Conference　2002
Publisher: Institute of Electrical and Electronics Engineers Inc.
DOI： 10.1109/INTMAG.2002.1001389 　

ISSN： 0074-6843
Changes of Lip and Tongue Pressures following Myofunctional Therapy : For Skeletal Open-bite Patients Treated Surgically

SAITO Hiroko, KAWAUCHI Mitsuhiko, TOMIZUKA Ryo, KANETAKA Hiroyasu, MITANI Hideo

東北矯正歯科学会雑誌 = Journal of Tohoku Orthodontic Society　9　(1)　48-56　2001/12/07

ISSN： 1340-2668
歯科治療に伴うストレスに関する研究歯科矯正装置の装着による影響

本間一弘, 渡部芳彦, 金高弘恭, 阿部昌子, 阿部一彦, 菊池雅彦, 渡辺誠

ストレス科学　16　(2)　126-126　2001/10
Publisher: 日本ストレス学会
ISSN： 1349-4813
Age-related morphometric changes of the human hyoid bone

Y Shimizu, H Kanetaka, Y Kim, K Ooya, M Kikuchi, H Mitani

JOURNAL OF DENTAL RESEARCH　80　(4)　1332-1332　2001/04

ISSN： 0022-0345
Changes of the Tongue Position and Head Posture following Orthognathic Surgery in Anterior Open Bite

KANETAKA HIROYASU, KAWAUCHI MITSUHIKO, KAWAMURA HIROSHI, MITANI HIDEO

The Japanese Journal of Jaw Deformities　11　(1)　35-46　2001
Publisher: THE JAPANESE SOCIETY FOR JAW DEFORMITIES
ISSN： 0916-7048

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Past studies have shown that malposition of the tongue is recognized as a major cause of anterior open bite, and many studies have investigated the relationship between open bite and the tongue. However, no studies have measured changes of the tongue position for a long period after orthognathic surgery. A new wireless telemeter system was developed to measure the tongue position and head posture in skeletal mandibular prognathism with anterior open bite before and after orthognathic surgery. The purpose of this study was to investigate the mechanism of adaptation of the peri-oral soft tissue to the new jaw relationship that had been reconstructed by orthognathic surgery. Data were obtained presurgically and after a debonding period for three cases whose occlusions were stable, and they were compared with the corresponding data of 23 normal occlusions. The results were as follows: 1) Change in the tongue-contacting area The tongue-contacting area was larger in two cases before orthognathic surgery than that of the normal occlusions. In another case, at the area of the mandible, similar results were obtained, but at the maxilla, the presurgical tongue-contacting area was smaller than that of the normal occlusions. In all cases, the tongue-contacting area before orthognathic surgery became similar to that of normal occlusions by correction of the jaw-relationship and occlusion. 2) Change of head posture In all cases, the head posture was not significantly different from that in normal occlusions. However, the head posture showed a slight backward inclination after orthognathic surgery. The results suggest that head posture and the peri-oral soft tissues, including the tongue, might have adapted to the jaw-relationship and occlusion that is newly reconstructed by orthognathic surgery.
テレメータシステムを用いた開咬症患者の活動時における頭位と舌位に関する研究

金高弘恭

日本顎変形症学会雑誌　6　(2)　264-264　1996/10
Publisher: (NPO)日本顎変形症学会
ISSN： 0916-7048

eISSN： 1884-5045

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Books and Other Publications 2

DorriM, NasserM, Oliver R.

Kanetaka H, Yuasa H

2009/05/13
Littlewood SJ, Millett DT, Doubleday B, Bearn DR, Worthington HV

Kanetaka H, Moori K

2008/04/01

Presentations 41

共振型磁気マーカを用いた顎運動計測システムの試作

薮上信, 早坂幸浩, 金高弘恭, 枦修一郎, 荒井賢一

電気学会マグネティックス研究会　2009/09/25
NiMnGa粒子分散ポリマーコンポジットの粒子分散状態と磁場誘起ひずみ

奥野元貴, 稲邑朋也, 細田秀樹, 清水良央, 金高弘恭

日本金属学会秋期大会講演　2009/09/15
モーションキャプチャ用多層薄型マーカの試作

早坂幸浩, 薮上信, 金高弘恭, 枦修一郎

日本磁気学会第33回学術講演会　2009/09/14
細長ワイヤレス磁気マーカによる位置検出の検討

佐藤龍介, 薮上信, 小澤哲也, 枦修一郎, 金高弘恭

日本磁気学会第33回学術講演会　2009/09/14
モーションキャプチャ用多層薄型マーカ

早坂幸浩, 薮上信, 金高弘恭, 枦修一郎

電気学会東北支部大会　2009/08/21
細長ワイヤレスマーカを用いた位置検出の検討

佐藤龍介, 薮上信, 小澤哲也, 枦修一郎, 金高弘恭

電気学会東北支部大会　2009/08/21
形状記憶合金の医療分野への応用展開

第58回精密工学研究所シンポジウム－形状記憶合金の基礎と応用－　2009/08/13
ヒト内舌筋の加齢変化

狩野充浩, 清水良央, 工藤忠明, 金高弘恭

第20回日本老年歯科医学会学術大会　2009/06/19
Integration of excitation coil and pick-up coil array for wireless magnetic motion sensing system. International-presentation

Hashi S, Kamisaka F, Yabukami S, Kanetaka H, Ishiyama K, Arai K I

IEEE International Magnetics Conference 2009　2009/05/04
Jaw Tracking System Using Resonated Wireless Markers International-presentation

Yabukami S, Hashi S, Kanetaka H, Arai K I, Sato T

IEEE International Magnetics Conference 2009　2009/05/04
位置検出システム用アモルファスリボン積層薄型磁気マーカに関する検討

神坂文康, 枦修一郎, 金高弘恭, 石山和志, 薮上信, 荒井賢一

平成21年電気学会全国大会　2009/03/17
ワイヤレス磁気マーカによる顎運動計測システム

薮上信, 金高弘恭, 枦修一郎, 荒井賢一, 佐藤忠邦

平成21年電気学会全国大会　2009/03/17
Flp-In/T-RExシステムを応用したII型骨形成因子(BMP)受容体の新しい機能に関する網羅的解析

工藤忠明, 清水良央, 張曄, 岡山啓昌, 渡辺亮, 趙菲, 狩野充浩, 田村眞理, 金高弘恭, 林治秀

第54回東北大歯学会　2009/02/27
Wireless magnetic motion capture system for medical use International-presentation

Kanetaka H, Yabukami S, Hashi S, Arai K I

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
Establishment of a stable and regulable 293 cell line expressing the type II bone morphogenetic protein receptor: an approach toward proteome analysis. International-presentation

Kudo T, Watanabe A, Asano M, Zhang Y, Zhao F, Kano M, Shimizu Y, Kanetaka H, Tamura S, Hayashi H

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
Role of the extracellular-signal-regulated kinase 5 (ERK5) pathway for neural differentiation in P19 embryonal carcinoma cells. International-presentation

Zhang Y, Kudo T, Ku M, Zhao F, Kano M, Shimizu Y, Hayashi H, HamadaT, Kanetaka H

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
Zhao F, Kudo T, Zhang Y, Kano M, Tamura S, Shimizu Y, Kanetaka H, Hayashi H International-presentation

Regulation of, the, reonine phosphatase Dullard in the course of neural, differentiation of, embryonal carcinoma cell

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
Genome-wide analysis of the regulation of BMP2-induced gene expression by inflammatory cytokine TNF-a in a stable 293 cell line expressing BMPRII. International-presentation

Okayama K, Kudo T, Shimizu Y, Zhang Y, Zhao F, Kano M, Kanetaka H, Sasaki K

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
In vivo Biodegradation and Biocompatibility Evaluation of Magnesium and Magnesium Alloys International-presentation

Shimizu Y, Yamamoto A, Mukai T, Shirai Y, Kano M, Kudo T, Kanetaka H, Kikuchi M

The 3rd International Symposium for Interface Oral Health Science in Sendai　2009/01/15
Numerical Study on Improvement of Detection Accuracy for Wireless Magnetic Motion Capture System. International-presentation

Hashi S, Yabukami S, Kanetaka H, Ishiyama K, Arai K I

Asian Magnetics Conference 2008 (AMC 2008)　2008/12/10
ワイヤレス磁気マーカを用いた位置検出システム

枦修一郎, 神坂文康, 薮上信, 金高弘恭, 石山和志, 荒井賢一

東北大学電気通信研究所工学研究会スピニクス特別研究会　2008/11/27
Niフリー生体用形状記憶合金の医療応用へ向けた生物学的検討

精研談話会　2008/11/20
顎顔面領域に対するNiフリー形状記憶合金を利用した力学的応用に関する検討

金高弘恭, 清水良央, 工藤忠明, 細田秀樹, 佐々木啓一

第50回歯科基礎医学会　2008/09/23
生体吸収性マグネシウム合金の生体内動態に関する研究

清水良央, 山本玲子, 向井敏司, 白井暢子, 狩野充浩, 岡山啓昌, 工藤忠明, 金高弘恭, 菊地正嘉

第50回歯科基礎医学会　2008/09/23
c-Jun N-terminal Kinase is a possible regulator of proton-associated sugar transporter-A.

工藤忠明, 清水良央, 金高弘恭, 林治秀

第50回歯科基礎医学会　2008/09/23
励磁コイル及び検出コイルアレイ一体型位置検出システムの検討

枦修一郎, 神坂文康, 薮上信, 金高弘恭, 石山和志, 荒井賢一

第32回日本磁気学会学術講演会　2008/09/12
ワイヤレス磁気マーカによる位置検出精度向上の検討

薮上信, 枦修一郎, 金高弘恭, 荒井賢一

ワイヤレス磁気マーカによる位置検出精度向上の検討　2008/09/12
Mechanical Applications of Ni-free Shape Memory Alloy for Maxillofacial Treatment International-presentation

Kanetaka H, Shimizu Y, Kudo T, Hosoda H, Sasaki K

3rd international Symposium on NANO-BIO and AMORRPHOUS MATERIALS　2008/08/07
ワイヤレス磁気マーカの位置検出システムにおける位置精度向上の検討

薮上信, 枦修一郎, 金高弘恭, 荒井賢一

電気学会マグネティックス研究会　2008/07/31
生体用モーションキャプチャシステムの開発および機能性生体材料の医療応用に関する研究

東北大学先進融合領域フロンティアプログラム中間シンポジウム　2008/07/16
マグネシウム合金の生体材料応用

清水良央, 山本玲子, 向井敏司, 白井暢子, 狩野充浩, 千葉亜耶美, 金高弘恭, 菊地正嘉

日本実験力学会2008年度年次講演会　2008/06/30
STUDY ON DOWNSIZING OF LC MARKER FOR WIRELESS MAGNETIC MOTION CAPTURE SYSTEM International-presentation

Hashi S, Ohya M, Uchiyama M, Yabukami S, Kanetaka H, Ishiyama K, Okazaki Y, Arai I K

European Magnetic Sensors & Actuators Conference (EMSA 2008)　2008/06/30
JNKによるproton-associated sugar transporter-Aの制御機構

工藤忠明, 清水良央, 金高弘恭, 田村眞理, 林治秀

第60回日本細胞生物学会大会　2008/06/28
焼成骨補填材を用いた骨誘導再生法での新生骨改造に関する組織形態計測学的検討

清水良央, 岡山啓昌, 狩野充浩, 金高弘恭, 菊地正嘉

九州大学応用力学研究所研究集会「歯科医学におけるバイオメカニクスとバイオマテリアル」・九州大学・東北大学合同研究集会「生体－バイオマテリアル界面における生物学的・力学的相互作用」　2008/06/21
ヒト喉頭蓋における喉頭腺の加齢変化

狩野充浩, 清水良央, 金高弘恭, 工藤忠明, 菊地正嘉

第19回日本老年歯科医学会学術大会　2008/06/19
摂食機能評価のための新しい検査用ゼリーの開発と臨床応用の試み

金高弘恭, 幸地省子, 新井映, 中條哲

第32回日本口蓋裂学会総会学術集会　2008/05/28
チューインガム法による口唇裂・口蓋裂患者における咀嚼能力の経年変化に関する研究

幸地省子, 金高弘恭, 尾崎史浩

第32回日本口蓋裂学会総会学術集会　2008/05/28
Niフリー形状記憶合金を利用した顎顔面領域への力学的応用に関する検討

金高弘恭, 清水良央, 工藤忠明, 細田秀樹

第５回東北大学バイオサイエンスシンポジウム　2008/05/19
Application of Ni-free Ti-based shape Memory Alloy Wire for Orthodontic Treatment. International-presentation

Kanetaka H, Shimizu Y, Hosoda H, Tomizuka R, Suzuki A, Urayama S, Miyazaki S, Takano-Yamamoto T

1st Asian BioMaterials Congress　2007/12/06
New Orthopaedic Treatment in Cranium using Ti-based SMA Wire International-presentation

Shimizu Y, Kanetaka H, Hosoda H, Urayama S, Kano M, Okayama K, Kikuchi M

1st Asian BioMaterials Congress　2007/12/06
平面型ワイヤレス磁気マーカの検討

薮上信, 金高弘恭, 枦修一郎, 荒井賢一

第31回日本応用磁気学会学術講演会 13aB-5　2007/09/11

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Industrial Property Rights 16

光触媒機能性部材およびその製造方法

成島尚之, 上田恭介, 上田隆統志, 佐渡翔太, 小笠原康悦, 伊藤甲雄, 金高弘恭

Property Type: Patent
医療用カルシウム系金属ガラス合金成形体及びその製造方法

金高弘恭, 謝国強, 高田朝

Property Type: Patent
運動努力をトリガとした同期的磁気刺激を行うリハビリテーションシステム

出江紳一, 高木敏行, 永富良一, 金高弘恭, 阿部利彦, 森仁, 八島建樹, 森和美

Property Type: Patent
マグネシウム・鉄合金の製造方法、マグネシウム・鉄合金及びそれを用いた生体医療材料

謝国強, 金高弘恭, 高田朝

Property Type: Patent
空冷式磁気パルス発生コイル

阿部利彦, 森仁, 八島建樹, 森和美, 高木敏行, 出江紳一, 永富良一, 金高弘恭

特許第6575741号

Property Type: Patent
空冷式磁気パルス発生コイル

阿部利彦, 森仁, 八島建樹, 森和美, 高木敏行, 出江紳一, 永富良一, 金高弘恭

Property Type: Patent
医療用磁気パルス発生装置

阿部利彦, 森仁, 八島建樹, 森和美, 高木敏行, 出江紳一, 永富良一, 金高弘恭

Property Type: Patent
連続磁気パルス発生装置

高木敏行, 出江紳一, 金高弘恭, 永富良一, 阿部利彦, 森仁, 八島建樹

Property Type: Patent
連続磁気パルス発生装置

高木敏行, 出江紳一, 金高弘恭, 永富良一, 阿部利彦, 森仁, 八島建樹

特許第5893689号

Property Type: Patent
医療用連発磁気パルス発生装置

阿部利彦, 森仁, 八島建樹, 森和美, 高木敏行, 出江紳一, 金高弘恭, 永富良一

特許第5771261号

Property Type: Patent
医療用連発磁気パルス発生装置

阿部利彦, 森仁, 八島建樹, 森和美, 高木敏行, 出江紳一, 金高弘恭, 永富良一

Property Type: Patent
マグネシウムを含む金属ガラスを用いた医療用インプラント材料、及びマグネシウムを含む金属ガラスを用いた医療用インプラント材料並びに医療用インプラント製品の製造方法

謝国強, 秦風香, 金高弘恭, 矢吹浩一, 山口一良

Property Type: Patent
生体内３次元運動測定装置及びその方法

金高弘恭

中国特許登録第ZL200580017779.7号

Property Type: Patent
磁気発生器並びに３次元運動測定装置及びその方法

金高弘恭

4310159

Property Type: Patent
３次元運動測定装置およびその方法並びに３次元位置検出装置

4326721

Property Type: Patent
INSTRUMENT AND METHOD FOR MEASURING THREE-DIMENSIONAL MOTION

Hiroyasu Kanetaka, Ken-ichi Arai, Shin Yabukami

米国特許登録第7402996号

Property Type: Patent

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Research Projects 55

Development of antibacterial-expressing self-maintenance implant surfaces using biological window

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2024/04/01 - 2028/03/31
レーザ誘起微細周期構造の構造制御ダイナミクスと構造／生体組織間相互作用の解明

水谷正義, 中村圭祐, 金高弘恭

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2022/04/01 - 2025/03/31
Materials surface design to inactivate coronaviruses by focusing on spike proteins

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2021/04/05 - 2025/03/31
骨格性反対咬合を有する片側性唇顎口蓋裂患者に対するBAMPの臨床試験

五十嵐薫, 島田栄理遣, 山内健介, 金高弘恭, 高橋哲

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2025/03/31

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口唇口蓋裂とは様々な遺伝的・環境的要因により口唇や顎堤、口蓋に裂を生じる先天性疾患である。出生後、口唇形成術・口蓋形成術によって裂は閉鎖されるが、術後の瘢痕によって上顎骨の成長抑制を生じることが多い。多くの医療施設では乳歯列期~混合歯列期に上顎前方牽引装置を用いて骨格的不調和を改善する治療が行われるが、その効果は患者の協力度に依存し、副作用も生ずるため、成長期における新たな治療法の開発が求められている。近年、上下顎骨に埋入したアンカープレートと顎間ゴムを用いて上顎骨を前方に牽引する方法が考案され、BAMPと呼ばれるようになった。この装置は患者の協力も得られやすく、歯性に生じる副作用もほとんど伴わずに骨格的不調和を改善することが可能である。本研究の目的は、口唇口蓋裂を有する骨格性反対咬合の患者に対するBAMPの効果と副作用について明らかにすることである。本研究は、前年度末に認定臨床研究審査委員会（国立大学法人東北大学東北臨床研究審査委員会；東北厚生局）から承認を受けている。2021年6月には東北大学病院から校費負担患者制度の利用についても承認を得ることができ、本臨床試験を開始するための準備が整った。直後から被験者の候補となる患者への説明を開始し、2021年度中に5名の患者から、研究への参加の同意が得られた。内4名はBAMP群として登録し、残り1名はコントロール群として登録した。BAMP群の患者にはアンカープレートを左右の上顎骨頬骨下稜部および下顎骨体部前方に埋入した。アンカープレート埋入2週間後から、上顎骨の前方牽引を開始している。4名中3名の患者で一部のアンカープレートの動揺が生じ、再埋入が必要となっており、対策が必要と考えている。
Elucidation of the coalescence mechanism of nanobubbles and development of novel nano-reaction fields

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

2021/04/01 - 2024/03/31
Generation of antibacterial performance and biocompatibility due to titanium oxide coating with a segmented structure

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Japan Fine Ceramics Center

2021/04/01 - 2024/03/31
Functionalization of implant by bio-active coating with ion release and high bonding strength

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2020/04/01 - 2024/03/31
二次元ナノ構造酸化チタンの表面欠陥と形態制御および抗感染性医用材料への応用

橋本雅美, 金高弘恭

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 一般財団法人ファインセラミックスセンター

2020/04/01 - 2023/03/31

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酸化チタンナノシートの作製を層状チタン酸化物(K0.8Ti1.73Li0.27O4を出発原料に使用して行った。具体的には、酸水溶液で処理し、層状構造を維持したままアルカリ金属を水素イオンに交換した。水酸化テトラブチルアンモニウムを層間に導入し、剥離し、ナノシートを作製した。本酸化チタンナノシート分散のコロイド溶液とカチオン性ポリマー溶液に交互に浸漬する交互吸着法を用いて、純チタン表面にナノシート/ポリマー膜を10層積層させた。その表面での抗菌性を評価した結果、抗菌性は発現しなかったが、骨芽細胞活性に関しては、細胞増殖およびALP活性とも良好であった。
MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金の創製

金高弘恭, 細田秀樹, 高瀬圭, 沼野智一, 古谷真衣子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(B)

Category: 基盤研究(B)

Institution: 東北大学

2019/04/01 - 2022/03/31

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近年、形状記憶効果と超弾性特性を併せ持つ形状記憶合金が着目されるようになった。しかしながら、現在、唯一実用化されているNiTi合金は、生体安全性への懸念、MRI撮影やX線CT撮影時の金属アーティファクト、さらに、血管X線撮影では低い視認性など、臨床的な問題が指摘されている。そこで本研究では、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証する。本研究では、最新の材料学技術に基づく合金設計および組成制御により、MRIアーティファクトフリーとX線視認性を両立させた新規医療用形状記憶合金を創製することを目的とした。具体的には、人体と同じ体積磁化率を有し、かつ重元素で構成される形状記憶合金としてAuCuAl合金を作製する。材料特性および生体適合性についての評価結果を材料作製段階までフィードバックしながらMRIアーティファクトフリーとX線視認性を両立させた合金を開発し、その生物学的安全性と臨床的有効性を検証した。本年度の研究成果として、開発したAuCuAl合金に対する性能評価を行った。具体的には、①形状可変機能（形状記憶・超弾性）および機械的特性評価、②MRIアーティファクト評価、③X線視認性評価、④生体適合性評価により開発合金の性能評価を行った。
動画モーションキャプチャによる摂食嚥下機能の外部観察評価システムの構築

貴田岡亜希, 佐々木啓一, 金高弘恭, 猪狩和子, 長沼由泰

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2019/04/01 - 2022/03/31

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本研究では、口腔顔面領域のモーションキャプチャ技術を利用し、摂食時の動画撮影のみで摂食嚥下機能の外部観察評価を簡便に、客観的に行うシステムを開発する。さらに、その信頼性の確認と適切な解析点、解析内容の選定のため、赤外線反射マーカーを用いた3次元モーションキャプチャシステムによる解析を行い、特徴点抽出による動画解析結果と照合する。これらを正常者・摂食嚥下機能障害者について行うことで、現行の主観的な外部観察評価の観点を客観的に表現しうる解析点、評価指標を決定する。本年度は、東北大学歯学研究科倫理委員会による承認を受けた後、健常成人被験者を用いて、モーションキャプチャカメラによる計測方法の検討を行った。顔面のどの部位を固定点と設定すると、摂食動作・嚥下動作を精度よくトラッキングが行えるのかを検索するために、被験者の顔面に赤外線反射マーカーを貼付した状態で食品を自由摂取させたデータを収集した。モーションキャプチャカメラはOptiTrack V120:Trio （30万画素120Hz、3台一体型）（アキュイティー株式会社製）を使用し、直径3ミリの半球状赤外線反射マーカーを顔面に貼付し、食品を自由摂取させ撮影を行った。固定点は額中央、鼻根、上口唇中央、下口唇中央、左右口角、オトガイ、喉頭とし8点とした。自由摂取する食品は、ヨーグルト、グミ、せんべいを選択した。引き続き、撮影の際に基準となる固定点の選択、食品の種類や摂取方法について検討を重ねている。
Creation of optically-functional titanium surface with compatibility of bone forming ability and antibacterial activity and its application to implants

Narushima Takayuki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2018/04/01 - 2022/03/31

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We succeeded in fabricating a Ti surface with both osteogenic and antibacterial properties for application to dental implants. The Au-containing TiO2 layers prepared on the Ti surface by an original process based on Au-sputtering and thermal oxidation showed antibacterial activity against E. coli under visible-light irradiation. The photofunction of the Au-containing TiO2 layers obtained in this study is considered to be an achievement to realize the “self-maintenance function” in which the implant itself plays a role in “healing” by reattaching to bone tissue and also enables “prevention” by patients themselves. These results, together with the excellent adhesion between the TiO2 layers and the Ti substrates, are expected to be applied not only to dental implants but also to the prevention of contact infection of the new coronavirus (SARS-CoV-2).
Development of an OCT intraoral scanner equipped with a high-speed swept source surface emitting laser

Sasaki Keiichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Further development of the digital dentistry requires a breakthrough of the intraoral scanner that enables improvement of measurement accuracy and measurement of the subgingival margin. The purpose of this study was to develop SS-OCT (Swept Source Optical Coherence Tomography) intraoral scanner with an intraoral probe using a swept source surface emitting laser that enables high-speed wavelength scanning integrated with a MEMS (Micro Electro Mechanical Systems) actuator as a light source. In this study, we confirmed the clinical usefulness of the newly developed device.
Development of 3D oral and nasopharyngeal impression taking method using shape memory gel and balloon technology

Koyama Shigeto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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The aim was to evaluate the physical properties of shape memory hydrogel (SMG) for application of dental impression material in the use of maxillofacial prosthodontics. The SMG has the unique properties that it softens when heated, can maintain its shape when cooled, and returns to its original shape when reheated. Specimens were prepared by changing the polymerization initiator and the mixing ratio of the two monomers (SA, LA) of SMG. Physical properties were evaluated using a tensile test and evaluation of shape memory characteristics (fixation rate, recovery rate). The switching of the polymerization initiator of SMG to CQ enabled polymerization with the dental photopolymerization devices. It was confirmed that the shape memory property, an original characteristic of SMG.
Electromyographic evaluation of the swallowing training by magnetic stimulation.

Hanawa Soshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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This study focused on the fact that the newly developed magnetic stimulator can cause muscle contraction with less painful stimuli than electrical stimulation; thus, we applied muscle contraction to the suprahyoid muscles. We aim to strengthen the anterior-upper elevation of the hyoid bone, which is a necessary movement for swallowing and effective swallowing training. During this research period, the conditions for magnetic stimulation were established, and clinical research was started with the approval of the Hospital Ethics Review Committee. It is expected that the results of this study will enable more patients to receive less painful and practical training for patients with swallowing disorders.
Brain functional evaluation of pain induced by orthodontic tooth movement

Igarashi Kaoru

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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It is still not well-known about the features and mechanisms of pain caused by orthodontic tooth movement. The purpose of this study was to objectively evaluate the pain associated with orthodontic tooth movement by measuring somatosensory evoked magnetic fields (SEFs).The results showed that orthodontic force application to mandibular first molar didi not affect the first peak latency, whereas significantly reduced the peak intensity immediately after 24 hours of the force application.Thus, it was suggested that pain signals induced by the mechanical stimulation to periodontal ligament might be decreased in the central nervous system.
Development of iron nitride microspheres for hyperthermia with highly efficient heating, automatic temperature control, and arterial embolization

Kawashita Masakazu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2018/06/29 - 2020/03/31

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Fe16N2, which is one of the iron nitrides, was obtained by reducing and nitriding magnetite (Fe3O4). Thus obtained Fe16N2 was estimated to show higher heat-generating ability than Fe3O4, and its cytocompatibility was almost same as that of Fe3O4. Further, it was found that Fe and Fe8N -deposited silica glass microspheres were obtained when silica glass microspheres were immersed in hydrofluoric acid containing iron ions and subjected to reduction-nitriding treatment.
Development of efficient and versatile method for inducing neuronal differentiation with temperature-controlled repeated thermal stimulation (TRTS)

Kudo Tada-aki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04/01 - 2020/03/31

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Neurite formation is a phenomenon that enables functional formation and recovery of the nervous system. Previously, we found a method to induce neurite outgrowth of rat PC12 cells in a temperature-controlled repeated thermal stimulation (TRTS)-dependent manner using a heating plate capable of controlling the medium temperature. However, there is still room for improvement in this method, which induces neuronal differentiation. The purpose of this study is to investigate the versatility of TRTS, the molecular mechanism of differentiation induction, and to improve the differentiation rate. Analysis using signal inhibitors and next-generation sequencing suggested the signaling molecules and signaling pathways that are involved in TRTS-induced neurite formation and in improving the neuronal differentiation rate.
Construction of comprehensive recovery system for peri-implantitis by selective radical application

Kanetaka Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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Dental implants are widely used as highly predictive treatments, however, there is no fundamental solution to peri-implantitis. Therefore, in this research, we aimed to construct a completely new comprehensive implant recovery system for peri-implantitis by selecting the site and time and applying radicals using the latest engineering technology. In this study, we first developed visible light responsive titanium oxide and atmospheric pressure plasma jet irradiation equipment that are most suitable for the implant recovery systems. Using these, we were able to acquire the basic technology to construct an implant recovery system that can be reliably and safely restored without removal in the oral cavity.
Development of surface potential-controlled Ti with high osteoblast activity and hydrophilicity

Hashimoto Masami

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Japan Fine Ceramics Center

2016/04/01 - 2019/03/31

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MC3T3-E1 cell differentiation and related surface potentials of rutile-type TiO2 scales formed on Ti are controlled by varying the Ti heat treatment conditions in a N2 atmosphere containing a trace amount of O2. The zeta potentials of the samples heated at 873 and 973 K for 1 h show large negative and positive values, respectively, while cell differentiation on the surface is enhanced in both cases (14 days incubation). In the case of untreated Ti, the cell differentiation diminishes and the zeta potential becomes more neutral. Protein detection and Ca and P detection, rather than an adhesive protein such as fibronectin, predominantly adsorbed on the scales formed in 1 h at 873 and 973 K, respectively. In the case of untreated Ti, fibronectin , but no Ca and P were detected. The present findings illuminate the relationship between charged surfaces and MC3T3-E1 cellular response.
Quest for fundamental dynamics of domain homo interface in shape change materials and principles for high performance materials

HOSODA Hideki, KANETAKA hiroyasu, CHANG tsu-fu mark, SHINOHARA yuri, CHERNEMKO volodymyr

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)

Category: Grant-in-Aid for Scientific Research (S)

Institution: Tokyo Institute of Technology

2014/05/30 - 2019/03/31

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In shape-change materials such as shape memory alloys and piezoelectric materials used for medical and energy applications, external fields such as force and magnetic field and material functions are deeply related each other。 The origin of the shape change is the domain rearrangement and phase transformation due to the motion of domain homo interface. In order to improve the material functions, the structure and dynamics of the domain homo interface have been clarified for the smooth motion with low friction. Principles for the control of interface structure and lattice softening from the first principle calculations have been established to reduce the friction of motion for the enhancement of higher functionality. Moreover, several multifunctional and high performance new shape change materials have been developed.
Development of porous metallic biomaterials with high strength, low elastic modulus and excellent biocompatibility

Xie Guoqiang

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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Porous Ni- and Be-free Ti-based bulk metallic glass (BMG) with a diameter exceeding 15 mm was developed by spark plasma sintering (SPS) the mixture of gas-atomized Ti-based glassy alloy powder and solid salt (NaCl) powder, followed by leaching treatment to eliminate the salt phase. The developed porous Ti-based BMG alloy exhibited high yield strength, simultaneously matched the Young’s modulus of natural bone, and demonstrated high corrosion resistance and excellent biocompatibility. These results suggest that porous Ti-based BMGs produced by the SPS process open an advanced alternative for clinical applications under load-bearing conditions such as surgical implants.
Assessment of the Externalizing and Internalizing Behavior Problems by Blocks Equipped with a Micro-accelerometer

Adachi Tomoaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Miyagi Gakuin Women's University

2015/04/01 - 2018/03/31

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This study aimed at assessing the effects of block play on salivary alpha-amylase activity (sAMY) in children who lived in affected or less affected area by the 2011 Great East Japan Earthquake. The experimental group was thirty-six 5-year-old children who lived in the affected area by the tsunami, and the control group was thirty-five 5-year-old children who lived in the less affected area. The participants played with blocks in unstructured playtime. The mean sAMY values of the experimental group and the control group were 31.1 and 31.4, respectively, before the playtime, but they were 41.4 and 24.1, respectively, after the playtime. A two-way mixed ANOVA was performed for the mean sAMY value with time of sampling as the within-subject factor and residential area as between subject factor. There was significant interaction between time of sampling and residential area. The results indicate that block play might reduce the stress-related anxiety of the children in less affected area.
Development of next generation bone graft material: Resorbable Magnesium-Metal glass

SHIOTA Makoto

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tokyo Medical and Dental University

2015/04/01 - 2018/03/31

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In oral rehabilitation for missing teeth, dental implant treatment is wide spreading for its functional and esthetic rehabilitation. To achieve ideal dental implant results, enough bone site should be needed. Dental implant treatment was often restricted by alveolar bone resorption and/or anatomical bone structure. We should consider bone graft procedure to overcome these situations. Gold standard for bone graft material is autogenous bone, though, harvesting autogenous bone cause morbidity to donor site. Therefore, development of bone graft material should be needed. Our research team developed Resorbable Magnesium-Metal glass. This material was considered gradually resorbing in animal body. This new bone graft material made by metallic atom, therefore, hardness and ductility of this graft material could higher than conventional Hydroxyapatite graft material. We demonstrated this new graft material’s potential for bone augmentation ability.
The study on the effects of orthodontic tooth movement on somatosensory evoked magnetic fields in cerebral cortex

Igarashi Kaoru, KANNO Akitake

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2015/04/01 - 2018/03/31

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It is still not well-known about the features and mechanisms of pain caused by the orthodontic tooth movement. The purposes of this study are to characterize the pain associated with orthodontic tooth movement objectively by measuring somatosensory evoked magnetic fields. The result of the study suggested that the transmission speed of twenty-four hours after the orthodontic tooth movement was faster than that of non-orthodontic tooth movement in a part of subjects. And, the comparison of the sense between the upper and the lower first molar’s periodontal ligaments generated by the mechanical stimulation showed the transmission speed of the lower first molar was faster and its signal strength was stronger than those of the upper first molar. Thus, the sense of the lower first molar periodontal ligaments has become a more important role in oral function than that of the upper first molar.
Fabrication of drug-release type implant using amorphous calcium phosphate film as a carrier

Ueda Kyosuke, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2017/03/31

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Bone morphogenetic protein (BMP) was loaded on amorphous calcium phosphate (ACP) film by immersion in BMP-2 solution. The releasing behavior of BMP-2 from ACP film was evaluated. The amount of BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was higher than that with heparin. The BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was released continuously for 12 h.
Brain functional analysis of somatosensory evoked magnetic field responses by occlusal stimulation to dental implants

KANETAKA HIROYASU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2017/03/31

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This study investigated the mechanism of information transmission from the somatosensory receptors of the periodontal ligament to the cerebral cortical somatosensory cortex, and the mechanism of compensatory sensory reception in dental implants by the brain functional method. Characteristics and localization of somatosensory evoked magnetic field responses evoked by occlusal stimulation of natural teeth and dental implants were examined using magnetoencephalography. Stimulus simulating occlusion was applied to the left lower canine and the first molar using our pressure trigger stimulation device in 20 adult volunteers. Contralateral response latency of the evoked magnetic field was significantly shorter in the first molar of the lower jaw than in the canine. In addition, the signal sources of the left lower canine and the first molar were located in almost the same region.
Psychological impact on parents after prenatal diagnosis of their infant's cleft lip, and psychosocial support for parents

MATSUMOTO MANABU

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Maebashi Kyoai Gakuen College

2014/04/01 - 2017/03/31

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This research was conducted for 3 years at the center of cleft lip and/or palate at Tohoku university hospital. The purpose of this study is to investigate the psychological impact on parents after prenatal diagnosis of their infant's cleft lip, and construct the psychosocial support for parents understanding about cleft and raise motivation of parenting. After 3 years research, over 70 parents were recruited this research. Our psychosocial support is gradually constructed with setting working a psychologist at the outpatients. Evidence from the research was reported at the conferences of Japanese Cleft palate association and will be reported at several conferences and papers. Our psychological support also will be keep providing with constructing psychological support model.
Development of adaptive plasticity using bidirectional stimulated brain machine interface

Izumi Shin-ichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2013/04/01 - 2017/03/31

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In order to apply neuromodulation and brain machine interface technology to human social interaction and promote appropriate plasticity induction, the measurement of inter-subject brain activity during the teach-learning that needs other-person interaction as like real life was carried out. We clarified the importance of metacognition and others' speculation in mutual social interaction. A prefrontal cortex is considered as a stimulation target of adaptive plasticity induction for human social interaction, and it is thought that human social interaction alters by adaptive plastic induction using neuromodulation according to brain activity.
Construction of nano-plasma control technique and biological function control by localized plasma irradiation

KANEKO Toshiro, KANZAKI Makoto, TACHIKAWA Masanori, KANETAKA Hiroyasu, TAKASHIMA Keisuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tohoku University

2012/06/28 - 2017/03/31

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In order to develop a highly efficient and minimally invasive drug delivery method, the applications of plasmas generated in liquid to control of biological response have been proposed. In the beginning, it has been experimentally verified that micro-scale plasma was generated by applying a pulse voltage to coaxial type thin electrode and had the capability to enhance the cellular uptake of drugs and genes. Next, investigation of effects of separated plasma-derived stimuli on drug uptake showed that plasma-produced short-lived reactive species contribute to the drug uptake. Furthermore, it is clarified that relatively short-lived reactive species (i.e., deactivated within approximately 10 min) in plasma-irradiated saline induced physiologically relevant calcium ion influx through ion channel on cell membrane, which triggers activation of gene and drug uptake.
Development of titanium with ex vivo antibacterial activity and in vivo osteoconductivity

Kawashita Masakazu, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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Ti treated with NaOH, hot water, and heated in an ammmonia gas atmosphere for 1 or 3 h showed in vitro apatite formation within 7 days when soaked in simulated body fluid (SBF). The treated Ti decomposed methylene blue and showed excellent bactericidal activity against Escherichia coli under visible light irradiation. A fine network of N-doped anatase-type titania (TiO2-xNx) formed on the Ti surface due to the surface treatment and was responsible for both the apatite formation in SBF and the visible-light induced antibacterial activity. These preliminary results suggest a simple method for producing novel bioactive Ti with visible light-induced antibacterial activity, which can be applied in orthopaedic and dental implants without the risk of infection.
Construction of a new implant recovery system by low-temperature plasma jet irradiation

Kanetaka Hiroyasu, SASAKI Keiichi, NARUSHIMA Takayuki, KANEKO Toshiro, KAWASHITA Masakazu, KUDO Tada-aki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2016/03/31

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The aim of this study was to construct dental implant recovery system in the oral cavity due to a completely new approach based on three pillars; ① powerful sterilization and infected tissue removal, ② re-activation treatment of the implant surface, ③ tissue regeneration, as a method of obtaining a functional and morphological recovery in the oral cavity without removing the dental implant with peri-implant inflammation. As research results, by application of the latest technology of low-temperature plasma jet, the base of the dental implant recovery system to promote good tissue regeneration was constructed by carrying out the safe sterilization and surface re-activation treatment in the oral cavity for the implant which has lost its biological activity.
Development of highly bioactive TiO2 particles for PMMA bone cement

Hashimoto Masami, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Japan Fine Ceramics Center

2013/04/01 - 2016/03/31

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TiO2 particles that were formed by heat treatment in a nitrogen atmosphere with an extremely low oxygen partial pressure exhibited high hydroxyapatite (HAp)-forming ability in simulated body fluid (SBF). X-ray diffraction (XRD), and scanning transmission electron microscopy (STEM) combined with electron energy loss spectroscopy (EELS) indicated that the particles were rutile-type TiO2, which scarcely contains nitrogen. Electron spin resonance (ESR) spectra revealed the reduction of Ti4+ in TiO2 to Ti3+ and the simultaneous introduction of oxygen vacancies to maintain charge neutrality. The enhanced HAp-forming ability of the TiO2 particles was likely related to their negatively charged surface, induced by water adsorption on oxygen vacancies, which resulted in acidic point formation. The compressive strength of PMMA-TiO2 bone cement was higher than that of commercial cement. Therefore, PMMA-TiO2 bone cement is considered to be useful for bone-reparing material.
Reduction of Chronic Stress in Younger Children Through Block Play

ADACHI Tomoaki, KITAMURA Yoshifumi, ITOH Youihi, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Miyagi Gakuin Women's University

2012/04/01 - 2015/03/31

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This study aimed at assessing the stress-reducing effects of block play. The experimental group was younger children affected by the tsunami and the control group was younger children not affected by the tsunami. Before and after the playtime, their salivary alpha-amylase activity (sAMY) was measured. Operational definition of block play was to manipulate the blocks in such a way as to conform to or explore one’s own conceptions in the process. Four of the 17 children in the experimental group and 11 of the 17 children in the control group engaged in block play meeting the operational definition (Fisher’s exact test, p=.0366). sAMY decreased in 10 of the 15 participants who met the operational definition of block play. sAMY did not decrease in 23 of the 24 participants who did not meet the operational definition (Fisher’s exact test, p=.0002). The results suggested that qualitative differences in block play may affect children’s post-play stress state.
A study on the relationship between lip closing functions, and the masticatory ability and articulatory function of the cleft lip and palate patients.

IGARASHI Kaoru, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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Lip closing functions is thought to be very important factor in maintaining a negative pressure in the oral cavity when performing a normal swallowing, and also to be affecting articulation and arch form of the teeth. In this study, we aimed to reveal the relationship between lip closing functions, and the masticatory ability and articulatory function of the cleft lip and palate patients. In order to achieve this purpose, a balloon type lip pressure measuring device and lip movement analyzing system were newly developed. In addition, optimization of the myoelectric measurement conditions specific to the lip closing function was performed. Furthermore, performing both the masticatory ability assessment by the chewing gum method and articulation assessment by speech therapist, it was possible to clarify the characteristics of the functional problems recognized in common by the entire cleft lip and palate patients.
Development of antibacterial bioactive Ti metal with light environment responsiveness

KAWASHITA Masakazu, MIYAZAKI Toshiki, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2012/04/01 - 2014/03/31

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Ti metal treated with NaOH, NH4OH, and heat and then soaked in simulated body fluid (SBF) showed in vitro apatite formation whereas that treated with NaOH, HNO3, and heat and then soaked in SBF did not. The anatase TiO2 precipitate and/or the fine network structure formed on the surface of the Ti metal treated with NaOH, NH4OH, and heat and then soaked in SBF might be responsible for the formation of apatite on the surface of the metal. The NaOH, NH4OH, and heat treatments might produce nitrogen-doped TiO2 on the surface of the Ti metal, and the concentration of methylene blue (MB) in the Ti metal sample treated with NaOH, NH4OH, and heat decreased more than in the untreated and NaOH- and heat-treated ones. This preliminary result suggests that Ti metal treated with NaOH, NH4OH, and heat has the potential to show photocatalytic activity under visible light.
Biomedical engineering approach to establish a new evaluation system for osteoconductivity by focusing on the protein adsorption properties to biomaterials

KANETAKA Hiroyasu, SASAKI Keiichi, SHIMIZU Yoshinaka, KUDO Tada-aki, KAWASHITA Masakazu, MURAYAMA Kazutaka

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2012/04/01 - 2014/03/31

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The aim of this study was to establish a new evaluation system for osteoconductivity by focusing on the protein adsorption properties to biomaterials. First, we revealed the difference in the three-dimensional conformational status of the protein on the surface of such osteoconductive biomaterials as hydroxyapatite, as well as the amount of adsorption, concerning the adsorption behavior of serum proteins. Next, by revealing the correlation between the proliferative capacity of mouse pre-osteoblastic cell line MC3T3-E1 and protein adsorption properties on the material, the possibility of a new evaluation system for osteoconductivity was investigated.
Development of degradation controlled alloy with long-term release of bioactive metallic ion

SHIMIZU Yoshinaka, YAMAMOTO Akiko, MUKAI Toshiji, KUMAMOTO Hiroyuki, IMAI Yoshimichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2011/04/01 - 2014/03/31

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Biodegradaion mechanism and effect of new bone formation of magnesium alloys were examined by animal implant experiments. In subcutaneous implant model, Two magnesium alloys of different composition showed different degradation rate. Magnesium alloy of slow rate degradation revealed rapid organization of surrounded tissue. In intraosseous implant model, magnesium alloys showed similar degradation behavior to subcutaneous implant model. New bone was formed around magnesium alloys. New bone formation showed gradual increase in magnesium alloy with high rate degradation. In magnesium alloy with slow rate degradation, bone showed initial increase and afterwords gradual decrease. Magnesium alloys showed high contact rate with bone. Magnesium alloy were demonstrated the high compatibility to bone tissue.
Formulation of the rare sugar delivery system for functional food and the safety assessment method

SHIRAI Yoko, TAKAHASHI Nobuhiro, KAMIMURA Wataru, KANETAKA Hiroyasu, SHIMIZU Yoshinaka, MATSUO Tatsuhiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: National Institute for Materials Science

2009/04/01 - 2014/03/31

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Although it has been difficult to supply a large amount of rare sugars, an inexpensive synthetic method on a large scale was recently established, leading to the reports on various physiological functions including regulation of blood glucose level and suppression of body fat accumulation. Meanwhile, it has been pointed out that rare sugars are difficult to utilize as foodstuffs by reason that they are excreted after the gut absorption more rapidly than typical monosaccharide. Therefore in present study, by applying drug delivery systems (DDS), we tried to bring the physiological functions of rare sugars into action efficiently by means of improving the stability in the body and prolonging the residence time. In addition, safety assessment methods for functional foods containing saccharides such as those exerted in the oral cavity were examined.
Development of absorption controllable bioceramic by analyzing activation mechanism of osteoclast precursor cells

ZHANG Ye, IOKU Koji, KUDO Tada-aki, SHIMIZU Yoshinaka, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2011 - 2013

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Two kinds of hydroxyapatites with different properties, hydrothermally synthesized hydroxyapatite (HHA) and stoichiometric hydroxyapatite (SHA) were used in this study. The basic technology for developing a new absorption controllable bioceramic could be obtained by revealing activation mechanism of osteoclast precursor cells comparing these two kinds of hydroxyapatites with different properties.
Development of new bone augmentation method using self-activated mesh device made by memory alloy

TAKAHASHI Tetsu, KANETAKA Hiroyasu, YAMAUCHI Kensuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

2011 - 2013

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New bone augmentation method using self activated mesh device made by memory alloy (SMA) was developed. We performed an animal experiment using Japanese white rabbits. The device was inserted under the periosteum at the forehead. We evaluated bone formation using micro-CT and histological method. The quantitative data by the area and the occupation of newly formed bone indicated that the experimental group had a higher volume of new bone than the control group. The use of self-activated devices for the periosteal expansion using SMA technique may make it possible to avoid donor site morbidity, and seems to be a viable method of bone augmentation.
Preparation of porous ceramic microspheres for multiple minimally invasive treatments of deep-seated cancer

KAWASHITA Masakazu, KANETAKA Hiroyasu, MITSUMORI Michihide

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2010 - 2012

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We revealed that chemically durable porous yttrium oxide microparticles 500 μm in diameter or yttrium phosphate microspheres 25 μm in diameter can be obtained by gelatin suspension method. Also, we found that hollow ceramic microspheres containing large amount of yttrium and phosphorus 30 μm in diameter can be obtained by spray-dry method. It is believed that the present microspheres are useful for intra-arterial multiple treatment of deep-seated cancer.
Basic research of inhibition of bone resorption on residual ridge using CNP hormone with local physiological effects.

OKAYAMA Keisuke, KUDO Tadaaki, SHIMIZU Yoshinaka, KANETAKA Hiroyasu, SASAKI Keiichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2010 - 2012

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In this study, local bone formation effects of CNP hormone was examined to develop a new clinical treatment of inhabitation of bone resorption on residual ridge. The bone defect of 8.8 mm diameter to expose the dura mater was made in rat cranium. Hydrothermal hydroxyapatite containing saline solution and CNP hormone was prepared and implanted in the defect area. The new bone was formed from peripheral bone and dura mater. The area of newly formed bone increased to 4 weeks after implantation. No significant differences in new bone area showed between saline and CNP groups. The diffusion velocity of CNP hormone in local area should be examined to understand of the in vivo local effect of CNP hormone.
Biomedical e xamination for t hree-dimensional control of c raniofacial form using new Ni-f ree s hape m emory a lloy.

KANETAKA Hiroyasu, SHIMIZU Yoshinaka, KUDO Tada-aki, YASUDA Satoshi, HOSODA Hideki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2009 - 2011

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The purpose of this study was to examine the possibility of three-dimensional craniofacial form control by the growth control of the suture using i nternalized d evice made of Ni-free Ti-based s hape m emory a lloy from the bi omedical engineering aspect. The animal experiment model which loads mechanical force on the suture of a growth phase rat cranium was produced. Biological and m orphometric al evaluation for the reaction of the suture against the mechanical stress was done in this study. As a result, it was suggested that three-dimensional form control of craniofacial regions could be performed by the device using a new shape memory alloy.
Development of the bioactive titanium alloy equipped with an osteoinductive property

TAKADA Yukyo, KANETAKA Hiroyasu, SHIMIZU Yoshinaka, KIKUCHI Masafumi, TAKAHASHI Masatoshi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2009 - 2011

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In this research program, we tried to develop the titanium alloy equipped with an osteoinductive property derived from sustained delivery of Mg ions. Although the Ti-Mg solid solution with the sustained delivery of Mg ions could not be obtained, under the conditions of Mg ions, the amount of DNAs and cell growth were as same as those of controls, and the ALP activity values significantly increased. Since the vascular proliferation was observed in the vascular endothelial cells and the lumen formation, we concluded that it is preferable to develop the Ti-Mg solid solution as anew functional material.
目標運動開始をトリガーとした骨格筋電磁誘導刺激システムの最適化

出江紳一, 高木敏行, 金高弘恭

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的萌芽研究

Category: 挑戦的萌芽研究

Institution: 東北大学

2009 - 2010

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平成22年度は、超小型ワイヤレス電磁マーカにより検出した手指の目標運動に、多連発パルス磁気刺激が特異的にトリガーされるシステムの開発を行った。具体的には、まず、運動への影響を極力排除するために小型化されたワイヤレス磁気マーカを運動測定対象の指先に装着し、磁気マーカの位置を磁気センサアレイにより磁気誘導の原理に基づき算出することで、手指の運動をリアルタイムで解析した。この場合に、パルス磁気刺激コイルが発生する強力なパルス磁場は、磁気センサに強いノイズ信号を誘発して機器を損傷する恐れがあった。実際、磁気センサアレイから30cm離れた距離に磁気刺激コイルを固定して、独自に開発したパルス磁場測定装置を用い磁気センサへの誘導起電力を測定すると1V以上の強いパルス電圧(2.5kHz)が観測された。一方、磁気マーカからの信号は100KHzであり、信号強度は10mV程度であった。そこで、シリコン半導体が0.7V以下の信号では動作しないという現象を活用することで、強い磁気パルス信号を遮断して、磁気マーカからの弱い信号のみを通過させるフィルター回路を開発した。このフィルター回路を使用することによって、強い磁気パルスの影響を受けずに、手指の運動解析を高精度で行うことが可能となった。本年度の研究では、上記の最新技術を利用することで、運動努力をトリガーとし、それに応じて多連発パルス磁気刺激を行うことができるシステムを構築し、正常ボランティアにおいて、システム全体の正常動作を確認した。
The development and application of composite functional medical device using new biodegradable magnesium alloy

SHIMIZU Yoshinaka, MUKAI Toshiji, YAMAMOTO Akiko

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2008 - 2010

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To apply biodegradable magnesium alloy for medical device, its biocompatibility and absorption velocity were examined in vitro and in vivo. In vitro, elevated activity of alkaline phosphatase was confirmed in osteoblast by magnesium ion addition. Magnesium alloy revealed the relationship between the degradation velocity and amount of gas formation. There was no pathological change in skin and bone tissue around magnesium alloy. The newly bone formation around magnesium alloy implant was seen in vivo examination. The biocompatibility and bone formation of magnesium alloy were confirmed by these results.
Analysis of a larynx function at swallowing by the motion capture system using a super-thin film magnetic field sensor

KANO Mitsuhiro, SHIMIZU Yoshinaka, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2007 - 2009

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The aim of this study was to measurement movement of hyoid and epiglottis at swallowing. In this study, It was revealed that three-dimensional position detection was possible in the living body of laboratory animals (rabbit) using some capture wireless magnetic markers in the magnetic motion capture system and date sampling of the movement of hyoid and epiglottis at swallowing was performed.
Development of Motion Capture System of Wireless Markers for Irradiation

YABUKAMI Shin, TAKAI Yoshihiro, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku Gakuin University

2006 - 2008
Analysis and clinical application of bone formation mechanism in immediate loading implant using materials driven by magnetic field

KIKUCHI Masayoshi, SASAKI Keiichi, HOSODA Hideki, CHIBA Mirei, SHIMIZU Yoshinaka, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2006 - 2007

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The aim of this study was to clarify the mechanism of bone formation in immediate loading implants using material driven by magnetic field and apply this material as clinical instrument. To control the loading, we utilized vibration using mixture materials of epoxy resin and magnetic substance metals (cobalt ferrite powder) in this study. The magnetic field to vibrate the materials and implant was provided by alternating electric and magnetic field (magnetic field: 0.5 tesla, the distance between magnetic poles) (TEM-5000-G1, Toei, Sendai). This machine can control the magnetic field intensity (Max: 0.649 tesla) by output current. We implanted the titanium alloy (diameter: 1.0-1.2 mm, length 10-15 mm) in femur and tibia of male rats. In experimental group, an end of implant was exposed on skin, and the material driven by magnetic field was fixed on the exposed end of implant. By alternating electric and magnetic field, implant vibrated through the intervention of material driven by magnetic field. Histological sections were observed. In initial stage, fibrous or granulation tissue with slight inflammatory cells infiltration was observed around implant. However, in long term observation, new bone formation without inflammatory reaction was seen around the implant. Newly formed bone was observed on the surface of implant in experimental and control groups. The optimal vibration will induce the bone formation and the prompt arrangement of bone trabecular around the implant. Clinically, the development of vibratory device may contribute to stabilize the implant for long time. The new medical treatment using materials driven by magnetic field will apply in various medical fields due to less invasive therapies.
Development of a magneto-driven orthodontic wire and its application for efficient tooth movement

IGARASHI Kaoru, KANETAKA Hiroyasu, SHIMIZU Yoshinaka, HOSODA Hideki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2006 - 2007

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The aim of this study was to develop a magneto-driven orthodontic wire and to apply this new wire for efficient tooth movement Orthodontic tooth movement is generated by the coupling of bone resorption on the compressed side of the periodontal ligament (PDL) and by bone formation on the stretched side of the PDL as a consequence of therapeutic mechanical stress. Since orthodontic treatment usually takes place over a long period of time, the risk of caries, periodontal disease, and prolonged treatment period are burdensome for the patient. Furthermore, it has been reported that total treatment duration proves to be highly correlated with root resorption. In this respect, it is important to accelerate alveolar bone remodeling during orthodontic treatment, to shorten the time required for successful therapy. Some studies revealed that mechanical stimulation by vibration accelerated the speed of tooth movement. On the other hand, the unique properties of shape memory and superelasticity have made shape memory alloys (SMAs) very useful biomaterials. Superelasticity is a phenomenon in which the stress value remains fairly constant up to a certain point of wire deformation. At the same time, when the deformed wire rebounds, the stress value remains fairly constant The property is very advantageous for orthodontic tooth movement, and the SMA wires have thus been widely used in orthodontic treatment. In this study, a titanium-niobium-aluminum (Ti-24Nb-3Al) SMA wire, which was considered to be biocompatible as a nickel free wire, was developed, and combined with a cobalt-based ferromagnetic SMA. Thus, a magneto-driven orthodontic wire was newly developed, and orthodontic palatal movement of maxillary first molars in Wistar-strain rats (age; 6 weeks) was performed with this new wire. The vibration was applied for ten minutes everyday by a wirelessly changing the magnetic field. The results suggested that the vibration accelerated orthodontic tooth movement.
Regeneration of periodontal ligaments in jawbone using materials driven by magnetic field

SHIMIZU Yoshinaka, HOSODA Hideki, KANETAKA Hiroyasu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku university

2005 - 2006

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The aim of this study was to construct the connective structure of hard tissue by fibrous ligaments in dynamic environment. For the development of the medical appliance, we selected elemental components and aligned the amplitude and frequency of magnetic materials reacting to magnetic gradient. We used the mixture materials of epoxy resin and magnetic substance metals (cobalt ferrite powder). In experiment of subcutaneous implantation, the biocompatibility of this material was confirmed histopathologically and physically. The healing of bone groove in rat cranium was investigated in static and dynamic states. The grooves of about 0.5, 1.0, and 1.5 mm breadth through the dura mater were formed in rat cranium. Histological sections were histologically observed. The groove of 1.5 mm breadth was connected with fibrous connective tissue. The groove of 1.0 mm breadth was reconstructed by bone tissue. Subsequently, the isolated bone surrounded by groove of 1.0 mm breadth, which will come under the dynamic influence of blood pressure in cranial cavity, showed no bony connection. In a part, the Sharpey's fibers, which reveal collagen fibers or bundles embedded in calcified tissue, were seen on the isolated and the surrounding bone surfaces. It was suggested that the Sharpey's fibers were formed by dynamic effects. To confirm the formation of Sharpey's fiber structure in tooth socket of jawbone, sintered tooth was implanted in first molar tooth socket in rat maxilla. Implanted teeth were extracted from else rats, and sintered in 1100℃, and sterilized. First molar tooth was extracted. And soon sintered tooth was implanted in extracted tooth socket. Sintered tooth was connected to second molar with resin. Granulation and fibrous connective tissue with slight inflammatory cells infiltration was present between sintered bone and alveolar bone on 10 days after implantation. It was suggested that the long-term observation is necessary.
Development of Jaw Movement Analyzer for Unilateral Cleft Lip and Palate Patients and Clinical Application

KOCHI Shoko, KANETAKA Hiroyasu, YABUKAMI Shin, ARAI Kenichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2004 - 2006

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In this study, a new jaw movement analyzer available with six degrees of freedom has been developed for unilateral cleft lip and palate patients. This new system does not need adaptors to connect devices inside and outside of the oral cavity, which interfere with a natural jaw movement, because it was organized on the basis of a magnetic motion capture system using an LC resonant marker. Moreover, the LC marker was small and had minimal circuit with no battery and could be driven wirelessly by action of electromagnetic induction. The system was composed of measurement instruments and coil assembly, consisting of a driving coil, LC markers, and a pick-up coil array. It was found that six degrees of freedom measurement and 60 Hz sampling cycles were achieved and the position accuracies of makers were within 1.0mm simultaneously using six LC resonant markers. This new system could capture six markers at the same with six degrees of freedom and drew a smooth path of jaw movement of cleft lip and palate patients. Furthermore the small magnetic markers in this system do not require any adaptors and allow us to measure the jaw movement under the natural conditions without obstruction. So, this system could be applied to young patients.
生体内モーションキャプチャシステムを応用した口腔機能総合解析システムの開発

金高弘恭

Offer Organization: 日本学術振興会

System: 科学研究費助成事業若手研究(B)

Category: 若手研究(B)

Institution: 東北大学

2004 - 2005

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本研究では、既存の装置では不可能であった下顎および舌の立体的な運動の同期的測定を行うことにより咀嚼、嚥下、発音などの口腔機能をより正確に評価し、さらには失われた機能に対するリハビリテーションにも応用可能なシステムを構築することを目的としている。具体的には、複数の小型永久磁石を磁気マーカとして利用した生体内直流磁界式モーションキャプチャシステムおよび6自由度運動計測方法での基本技術をベースとし、共同研究機関の本学電気通信研究所で開発に成功した常温では世界最高感度を有する高周波キャリア型薄膜磁界センサおよび交流磁界式のLC共振型ワイヤレス磁気マーカを導入することにより、口腔機能測定用として十分満足できるだけの100μm以下の位置精度を獲得することを目標とする。本年度は、口腔機能測定用として特化して開発された新システムにより、実際に被験者に対し測定を行い、実用化へ向けてさらなる改善を行った。 (1)データ解析用ソフトウェアの開発下顎や舌に配置された複数の磁気マーカより同期的に得られた計測データを解析し、下顎や舌を立体として構築した上で、6自由度運動として画面表示装置に表示するソフトウェアの開発を行った。 (2)システム全体の正常動作の確認磁気シールドルーム内において、非磁性体材料のみから製作された顎模型モデルを利用し、システム全体の正常動作の確認を行った。サンプリング速度やデータ処理速度に問題があったため、磁界センサ信号処理用電子回路、データ解析用ソフトウェアの修正を行い、問題点を解決した。 (3)システムの改善,利便性の向上開発されたシステムを用い、あらかじめ本研究について充分な説明を行い、同意を得たボランティアに対し口腔機能の測定を行ったところ、なめらかな運動軌跡を表記できることが確認された。今後、口腔機能のリアルタイム表示や口腔機能評価の自動化など、さらに操作性を高めたシステム構築を行っていく予定である。
超薄型高感度磁界センサを用いた顎機能診断装置の開発

薮上信, 三谷英夫, 荒井賢一, 金高弘恭, 河内満彦, 薮上信

Offer Organization: 日本学術振興会

System: 科学研究費助成事業萌芽研究

Category: 萌芽研究

Institution: 東北大学

2002 - 2003

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本研究では,我々の研究チームで開発された交流磁界式モーションキャプチャシステムを歯科医療分野に応用することにより,従来装置では測定が困難であった咀嚼や嚥下運動時の顎運動を,患者の負担の少ない状態で,顎機能異常の診査ではきわめて重要な下顎頭の運動も含め,より自然に近い状態で測定可能とする顎機能診断装置を開発し,その臨床応用を図ることにより,顎機能異常患者に対する機能的診断法を確立することを目的とした. 上記目的を達成するために我々が培ってきた磁気式モーションキャプチャシステムの基本技術をベースに,顎顔面領域に関する顎機能診断装置用に特化した交流磁界式モーションキャプチャシステムの開発を行った.磁界を媒体とした位置検出システムにおいて磁界強度は磁界発生源とセンサとの距離の3乗に反比例するため、センサと磁界発生源の距離が接近するほど原理的に高い位置分解能が可能である.本研究ではセンサおよび磁界発生用マーカが両方ともに口腔内に配置可能であり、従来の顎運動計測システムに比較して高い位置分解能が実現できると考えられる.顎運動の範囲をマーカの位置を求める際の制約条件として考慮することにより,位置精度は数十μm以内へ向上することが可能になると考えられる. 具体的には,まず位置精度計測用顎模型を利用し,システム全体の正常動作の確認を行った.つづいて顎模型を用いた標準的な動作において位置分解能を測定したところ、成人男子の最大変移である40mmの移動において最悪でも100μm程度の位置分解能を得られることを確認し、本システムが基本的に高分解能計測に向いていることを示した.6自由度の複雑な顎運動計測における位置精度は数mm程度であるが,将来的にはさらなる位置精度の向上を目指し,あわせて,表示分析ソフトに修正を加えることにより,臨床応用に近づける.
ゲノム解析による1児のみに口蓋裂の発現した10組の双生児に対する分子遺伝学的検討

金高弘恭

Offer Organization: 日本学術振興会

System: 科学研究費助成事業奨励研究(A)

Category: 奨励研究(A)

Institution: 東北大学

2000 - 2001

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本学歯学部付属病院顎口腔機能治療部に通院している双生児のうち1児にのみ口蓋裂の発現した10組の双生児に対して、口蓋裂を有するもの(口蓋裂群)と有さないもの(非口蓋裂群)それぞれから末梢血を採取し、ディファレンシャルmRNAディスプレイ法(以下DD法と略す)による分子遺伝学的解析を行った。 I.DD法による口蓋裂群特異的遺伝子断片の単離 DD法で得られた口蓋裂群特異的遺伝子断片は順次PCR反応を行った。さらにデータベース上で既知の情報と照会したところ、これら断片の一部にはMSX1、RARA、PAX9、AP2をはじめとした顎顔面発生の制御に関与するとされてる遺伝子やすでに口蓋裂発生の候補と報告されている遺伝子やその遺伝子と相同性の高い遺伝子が含まれ、さらに複数の未知の遺伝子断片が含まれることが確認された。 II.口蓋裂群特異的cDNAの全長単離 DD法で得られた口蓋裂群特異的遺伝子断片のうち特定された未知のものを利用し、5'-RACE法によりcDNAの全長を得た。さらにこれらcDNAをテンプレートしてランダムプライミング法により放射能標識したプローブを口蓋裂群と非口蓋裂群それぞれのtotal mRNA試料とハイブリダイゼーションさせることでノーザンブロッティングを行い口蓋裂群と非口蓋裂群との間で異なった発現パターンを示すことを確証した。 III.解析結果の比較検討 10組の双生児において、口蓋裂群・非口蓋裂群の両群の間で発現パターンが著しく異なる未の遺伝子が見出された。これら遺伝子について、口蓋裂発症の遺伝的要因である可能性を含め順次分子遺伝学的および統計的検討を行った。 *患者本人および保護者に本研究の趣旨を理解していただき同意を得た上で末梢血の採取を行った。また、関係者の人権および利益の保護には十分な配慮を図った。

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