Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality. International-journal Peer-reviewed

Akira Nishimura, Sunghyeon Yoon, Tetsuro Matsunaga, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Yuka Unno, Uladzimir Barayeu, Tsuyoshi Takata, Hiroshi Takagi, Hozumi Motohashi, Albert van der Vliet, Takaaki Akaike

Redox biology　69　103018-103018　2024/01/03

DOI： 10.1016/j.redox.2023.103018 　

Supersulfide biology and translational medicine for disease control. International-journal Peer-reviewed

Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike

British journal of pharmacology　2023/10/23

DOI： 10.1111/bph.16271 　

骨格筋におけるシステイニルtRNA合成酵素1(CARS1)によるポリスルフィド産生の生理学的機能

草野 佑典, 村上 昌平, 守田 匡伸, 井田 智章, 香取 幸夫, 赤池 孝章, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　96回　[1T04a-237)]　2023/10

Clinical, Genomic, and Transcriptomic Featurses of Lung Adenocarcinoma With Uncommon EGFR Mutation Peer-reviewed

Kazuki Hayasaka, Haruna Takeda, Akira Sakurada, Yuki Matsumura, Jiro Abe, Satoshi Shiono, Hirotsugu Notsuda, Hiroyuki Suzuki, Makoto Endo, Hozumi Motohashi, Yoshinori Okada

Clinical Lung Cancer　2023/10

DOI： 10.1016/j.cllc.2023.10.006 　

ISSN： 1525-7304

Aging Exacerbates Murine Lung Ischemia-Reperfusion Injury by Excessive Inflammation and Impaired Tissue Repair Response. International-journal Peer-reviewed

Kazuki Hayasaka, Shinya Ohkouchi, Ryoko Saito-Koyama, Yamato Suzuki, Keito Okazaki, Hiroki Sekine, Tatsuaki Watanabe, Hozumi Motohashi, Yoshinori Okada

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons　2023/09/19

DOI： 10.1016/j.ajt.2023.09.004 　

NRF2 signalling in cytoprotection and metabolism. International-journal Peer-reviewed

Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi

British journal of pharmacology　2023/09/15

DOI： 10.1111/bph.16246 　

Supersulfide catalysis for nitric oxide and aldehyde metabolism. International-journal Peer-reviewed

Shingo Kasamatsu, Akira Nishimura, Md Morshedul Alam, Masanobu Morita, Kakeru Shimoda, Tetsuro Matsunaga, Minkyung Jung, Seiryo Ogata, Uladzimir Barayeu, Tomoaki Ida, Motohiro Nishida, Akiyuki Nishimura, Hozumi Motohashi, Takaaki Akaike

Science advances　9　(33)　eadg8631　2023/08/18

DOI： 10.1126/sciadv.adg8631 　

Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. International-journal Peer-reviewed

Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi

Redox biology　65　102834-102834　2023/07/29

DOI： 10.1016/j.redox.2023.102834 　

Supersulphides provide airway protection in viral and chronic lung diseases. International-journal Peer-reviewed

Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike

Nature communications　14　(1)　4476-4476　2023/07/25

DOI： 10.1038/s41467-023-40182-4 　

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. International-journal Peer-reviewed

Ryo Ikeda, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Shun Kageyama, Yuko Fujioka, Tomoko Funakoshi, Satoko Komatsu-Hirota, Ritsuko Arai, Elena Ryzhii, Manabu Abe, Tomoaki Koga, Hozumi Motohashi, Mitsuyoshi Nakao, Kenji Sakimura, Arata Horii, Satoshi Waguri, Yoshinobu Ichimura, Nobuo N Noda, Masaaki Komatsu

The EMBO journal　e113349　2023/06/12

DOI： 10.15252/embj.2022113349 　

The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. International-journal Peer-reviewed

Haruna Takeda, Yoshihiro Nakajima, Teruaki Yamaguchi, Itaru Watanabe, Shoko Miyoshi, Kodai Nagashio, Hiroki Sekine, Hozumi Motohashi, Hajime Yano, Junya Tanaka

Journal of biochemistry　174　(2)　131-142　2023/04/11

DOI： 10.1093/jb/mvad030 　

Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism. International-journal Peer-reviewed

Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike

Antioxidants (Basel, Switzerland)　12　(4)　2023/04/03

DOI： 10.3390/antiox12040868 　

Contribution of NRF2 to sulfur metabolism and mitochondrial activity. International-journal Peer-reviewed

Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi

Redox biology　60　102624-102624　2023/02/02

DOI： 10.1016/j.redox.2023.102624 　

感染症における呼気オミックス解析

緒方 星陵, 井田 智章, 守田 匡伸, 松永 哲郎, 村上 昌平, 魏 范研, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　78　(1)　69-69　2023/02

ISSN： 0021-4930

eISSN： 1882-4110

細菌から動物まで種横断的に保存された超硫黄分子合成経路の発見

井田 智章, Jung Minkyung, 松永 哲郎, 守田 匡伸, 緒方 星陵, 高田 剛, 海野 雄加, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　78　(1)　75-75　2023/02

ISSN： 0021-4930

eISSN： 1882-4110

NADPHオキシダーゼおよび一酸化窒素合成酵素による超硫黄分子活性化と宿主防御機構

ジョン・ミンギョン, 高田 剛, 井田 智章, 松永 哲郎, 守田 匡伸, 土屋 幸弘, 渡邊 泰男, 本橋 ほづみ, 住本 英樹, 赤池 孝章

日本細菌学雑誌　78　(1)　75-75　2023/02

ISSN： 0021-4930

eISSN： 1882-4110

Helicobacter cinaediの超硫黄代謝を介した持続的な骨髄内感染機構の解明

松永 哲郎, 守田 匡伸, 西村 明, 井田 智章, 澤 智裕, 本橋 ほづみ, 河村 好章, 赤池 孝章

日本細菌学雑誌　78　(1)　93-93　2023/02

ISSN： 0021-4930

eISSN： 1882-4110

Structural basis of transcription regulation by CNC family transcription factor, Nrf2 Peer-reviewed

Toru Sengoku, Masaaki Shiina, Kae Suzuki, Keisuke Hamada, Ko Sato, Akiko Uchiyama, Shunsuke Kobayashi, Asako Oguni, Hayato Itaya, Kota Kasahara, Hirotomo Moriwaki, Chiduru Watanabe, Teruki Honma, Chikako Okada, Shiho Baba, Tsutomu Ohta, Hozumi Motohashi, Masayuki Yamamoto, Kazuhiro Ogata

Nucleic Acids Research　50　(21)　12543-12557　2022/12/01

DOI： 10.1093/nar/gkac1102 　

ISSN： 0305-1048

eISSN： 1362-4962

Establishment of Neh2-Cre:tdTomato reporter mouse for monitoring the exposure history to electrophilic stress. International-journal Peer-reviewed

Hiroshi Kitamura, Tetsuya Oishi, Shohei Murakami, Tomoe Yamada-Kato, Isao Okunishi, Masayuki Yamamoto, Yukio Katori, Hozumi Motohashi

Free radical biology & medicine　193　(Pt 2)　610-619　2022/11/09

DOI： 10.1016/j.freeradbiomed.2022.11.004 　

シスチン/グルタミン酸トランスポーターxCTの阻害による慢性炎症性腸疾患モデルでの抗炎症作用

岩城 英也, 関根 弘樹, 村上 昌平, 加藤 伸史, 北村 大志, 魏 范研, 福田 真嗣, 曽我 朋義, 角田 洋一, 正宗 淳, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　95回　1T08a-07　2022/11

NADPHオキシダーゼおよび一酸化窒素合成酵素によるグルタチオン依存的な超硫黄活性化とその生理機能の解明

緒方 星陵, 高田 剛, 井田 智章, 松永 哲郎, 守田 匡伸, Jung Minkyung, 土屋 幸弘, 渡邊 泰男, 本橋 ほづみ, 住本 英樹, 赤池 孝章

日本生化学会大会プログラム・講演要旨集　95回　3T18m-01　2022/11

CD3鎖を標的とした超硫黄分子によるTCRシグナルを介した免疫応答制御

守田 匡伸, 山田 充啓, 佐々木 優作, 井田 智章, 松永 哲郎, 高田 剛, 渡部 聡, 稲葉 謙次, 石井 直人, 杉浦 久敏, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　95回　3P-132　2022/11

シスチン/グルタミン酸トランスポーターxCTの阻害による慢性炎症性腸疾患モデルでの抗炎症作用

岩城 英也, 関根 弘樹, 村上 昌平, 加藤 伸史, 北村 大志, 魏 范研, 福田 真嗣, 曽我 朋義, 角田 洋一, 正宗 淳, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　95回　1T08a-07　2022/11

CD3鎖を標的とした超硫黄分子によるTCRシグナルを介した免疫応答制御

守田 匡伸, 山田 充啓, 佐々木 優作, 井田 智章, 松永 哲郎, 高田 剛, 渡部 聡, 稲葉 謙次, 石井 直人, 杉浦 久敏, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　95回　3P-132　2022/11

8-Nitro-cGMP suppresses mineralization by mouse osteoblasts. Peer-reviewed

Kotaro Kaneko, Yoichi Miyamoto, Tomoaki Ida, Masanobu Morita, Kentaro Yoshimura, Kei Nagasaki, Kazuki Toba, Risa Sugisaki, Hozumi Motohashi, Takaaki Akaike, Daichi Chikazu, Ryutaro Kamijo

Journal of clinical biochemistry and nutrition　71　(3)　191-197　2022/11

DOI： 10.3164/jcbn.21-129 　

Genetic, metabolic and immunological features of cancers with NRF2 addiction International-journal Peer-reviewed

Hiroshi Kitamura, Haruna Takeda, Hozumi Motohashi

FEBS Lett.　596　(16)　1981-1993　2022/08

DOI： 10.1002/1873-3468.14458. 　

CEBPB is required for NRF2-mediated drug resistance in NRF2-activated non-small cell lung cancer cells Peer-reviewed

Keito Okazaki, Hayato Anzawa, Fumiki Katsuoka, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi

The Journal of Biochemistry　171　(5)　567-578　2022/05/11

DOI： 10.1093/jb/mvac013 　

ISSN： 0021-924X

eISSN： 1756-2651

NRF2 Pathway Activation Attenuates Aging-Related Renal Phenotypes due to α-Klotho Deficiency. International-journal Peer-reviewed

Mingyue Zhao, Shohei Murakami, Daisuke Matsumaru, Takeshi Kawauchi, Yo-Ichi Nabeshima, Hozumi Motohashi

Journal of biochemistry　171　(5)　579-589　2022/02/07

DOI： 10.1093/jb/mvac014 　

ゲノムアラインメントおよびゲノム編集マウスの解析による硫黄転移酵素ロダネーゼの種横断的機能の解明

佐藤 聡, 守田 匡伸, ジョン・ミンキョン, 松永 哲郎, 高田 剛, 井田 智章, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　68-68　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

細菌・ミトコンドリアにおける硫黄転移酵素ロダネーゼを介した超硫黄代謝機構の解明

海野 雄加, 松永 哲郎, 守田 匡伸, Jung Minkyung, 高田 剛, 井田 智章, 吉沢 道人, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　69-69　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

酵母における超硫黄分子による寿命制御

Jung Minkyung, 西村 明, 井田 智章, 松永 哲郎, 守田 匡伸, 高木 博史, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　69-69　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

大腸菌におけるアミノアシル-tRNA合成酵素による超硫黄分子合成機構の解明

井田 智章, Jung Minkyung, 西村 明, 松永 哲郎, 守田 匡伸, 高田 剛, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　69-69　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

NADPHオキシダーゼおよび一酸化窒素合成酵素による超硫黄分子産生を介した感染防御機能

高田 剛, 井田 智章, 松永 哲郎, 守田 匡伸, 土屋 幸弘, 渡邊 泰男, 本橋 ほづみ, 吉沢 道人, 住本 英樹, 赤池 孝章

日本細菌学雑誌　77　(1)　104-104　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

超硫黄科学が切り拓くエネルギー代謝とストレス応答の新展開 超硫黄分子によるミトコンドリアエネルギー代謝と感染防御機構の解明

松永 哲郎, 澤 智裕, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　28-28　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

T細胞受容体シグナルを標的とした超硫黄分子による免疫応答制御

守田 匡伸, 山田 充啓, 佐々木 優作, 井田 智章, 松永 哲郎, 稲葉 謙次, 石井 直人, 杉浦 久敏, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　103-103　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

超硫黄科学が切り拓くエネルギー代謝とストレス応答の新展開 超硫黄分子によるミトコンドリアエネルギー代謝と感染防御機構の解明

松永 哲郎, 澤 智裕, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　77　(1)　28-28　2022/02

ISSN： 0021-4930

eISSN： 1882-4110

Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)

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The KEAP1-NRF2 System in Healthy Aging and Longevity. International-journal Peer-reviewed

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Antioxidants (Basel, Switzerland)　10　(12)　2021/11/30

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日本生化学会大会プログラム・講演要旨集　94回　[P-890]　2021/11

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日本生化学会大会プログラム・講演要旨集　94回　[P-371]　2021/11

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日本生化学会大会プログラム・講演要旨集　94回　[P-06)]　2021/11

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Nat Commun　12　(1)　3108-3108　2021/05

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Science advances　7　(17)　2021/04

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Redox Biology　43　101966　2021/04

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日本細菌学雑誌　76　(1)　105-105　2021/02

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Publisher Correction: Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. International-journal

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High-Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species International-journal Peer-reviewed

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Antioxidants & Redox Signaling　34　(18)　1407-1419　2021/01/04

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Nature Communications　12　(1)　2021

DOI： 10.1038/s41467-021-23143-7 　

ISSN： 2041-1723

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Ogishima, S., Nagaie, S., Mizuno, S., Ishiwata, R., Iida, K., Shimokawa, K., Takai-Igarashi, T., Nakamura, N., Nagase, S., Nakamura, T., Tsuchiya, N., Nakaya, N., Murakami, K., Ueno, F., Onuma, T., Ishikuro, M., Obara, T., Mugikura, S., Tomita, H., Uruno, A., Kobayashi, T., Tsuboi, A., Tadaka, S., Katsuoka, F., Narita, A., Sakurai, M., Makino, S., Tamiya, G., Aoki, Y., Shimizu, R., Motoike, I.N., Koshiba, S., Minegishi, N., Kumada, K., Nobukuni, T., Suzuki, K., Danjoh, I., Nagami, F., Tanno, K., Ohmomo, H., Asahi, K., Shimizu, A., Hozawa, A., Kuriyama, S., Yamamoto, M., Abe, M., Aizawa, Y., Aoki, Y., Chida, K., Danjoh, I., Egawa, S., Eto, A., Funayama, T., Fuse, N., Hamanaka, Y., Harada, Y., Hashizume, H., Higuchi, S., Hirano, S., Hirata, T., Hiratsuka, M., Hozawa, A., Igarashi, K., Inoue, J., Ishida, N., Ishii, N., Ishii, T., Ishikuro, M., Ito, K., Ito, S., Kageyama, M., Katsuoka, F., Kawame, H., Kawashima, J., Kikuya, M., Kinoshita, K., Kitatani, K., Kiyama, T., Kiyomoto, H., Kobayashi, T., Kodama, E., Kogure, M., Kojima, K., Koreeda, S., Koshiba, S., Koyama, S., Kudo, H., Kumada, K., Kure, S., Kuriki, M., Kuriyama, S., Kuroki, Y., Maikusa, N., Makino, S., Matsubara, H., Matsui, H., Metoki, H., Mimori, T., Minegishi, N., Misawa, K., Miyashita, M., Mizuno, S., Motohashi, H., Motoike, I.N., Nagaie, S., Nagai, M., Nagami, F., Nagasaki, M., Nagase, S., Nakamura, N., Nakamura, T., Nakaya, N., Nakayama, K., Narita, A., Nishijima, I., Nobukuni, T., Nochioka, K., Ogishima, S., Ohuchi, N., Olivier, G., Osumi, N., Otsu, H., Otsuki, A., Saigusa, D., Saito, S., Saito, T., Sakaida, M., Sakurai-Yageta, M., Sato, Y., Sato, Y., Sekiguchi, A., Shen, C.-Y., Shibata, T.F., Shimizu, R., Shimokawa, K., Shirota, M., Sugawara, J., Suzuki, K., Suzuki, Y., Tadaka, S., Taira, M., Takai-Igarashi, T., Takano, Y., Taki, Y., Tanabe, O., Tanaka, H., Tanaka, Y., Teraguchi, S., Terakawa, T., Tominaga, T., Tomita, H., Tsuboi, A., Tsuchiya, N., Tsuji, I., Ueki, M., Uruno, A., Yaegashi, N., Yamagishi, J., Yamaguchi-Kabata, Y., Yamanaka, C., Yamashita, R., Yasuda, J., Yokozawa, J., Waki, K., Sasaki, M., Akai, J., Endo, R., Fukushima, A., Furukawa, R., Hachiya, T., Hashizume, K., Hitomi, J., Ishigaki, Y., Komaki, S., Kotozaki, Y., Mikami, T., Nakamura, M., Nishiya, N., Nishizuka, S., Nomura, Y., Ogasawara, K., Ohmomo, H., Omama, S., Otomo, R., Otsuka, K., Oyama, K., Sakata, K., Satoh, M., Sato, N., Shimizu, A., Shiwa, Y., Sutoh, Y., Takanashi, N., Takebe, N., Tanaka, F., Tanaka, R., Tanno, K., Tokutomi, T., Yamamoto, K., Yamashita, F., Fuse, N., Tominaga, T., Kure, S., Kinoshita, K., Tanaka, H.

Human Genome Variation　8　(1)　2021

DOI： 10.1038/s41439-021-00175-5 　

ISSN： 2054-345X

Feedback repression of PPARα signaling by Let-7 microRNA

Yagai, T., Yan, T., Luo, Y., Takahashi, S., Aibara, D., Kim, D., Brocker, C.N., Levi, M., Motohashi, H., Gonzalez, F.J.

Cell Reports　36　(6)　2021

DOI： 10.1016/j.celrep.2021.109506 　

ISSN： 2211-1247

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response Peer-reviewed

Shun Kageyama, Sigurdur Runar Gudmundsson, Yu-Shin Sou, Yoshinobu Ichimura, Naoki Tamura, Saiko Kazuno, Takashi Ueno, Yoshiki Miura, Daisuke Noshiro, Manabu Abe, Tsunehiro Mizushima, Nobuaki Miura, Shujiro Okuda, Hozumi Motohashi, Jin-A Lee, Kenji Sakimura, Tomoyuki Ohe, Nobuo N. Noda, Satoshi Waguri, Eeva-Liisa Eskelinen, Masaaki Komatsu

Nature Communications　12　(1)　16-16　2020/12

DOI： 10.1038/s41467-020-20185-1 　

eISSN： 2041-1723

Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss International-journal Peer-reviewed

Tetsuya Oishi, Daisuke Matsumaru, Nao Ota, Hiroshi Kitamura, Tianxiang Zhang, Yohei Honkura, Yukio Katori, Hozumi Motohashi

npj Aging and Mechanisms of Disease　6　(1)　14-14　2020/12

DOI： 10.1038/s41514-020-00053-4 　

eISSN： 2056-3973

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers International-journal Peer-reviewed

Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, Hiroshi Kitamura, Yoshiaki Onodera, Md. Morshedul Alam, Daisuke Matsumaru, Takuma Suzuki, Fumiki Katsuoka, Shu Tadaka, Ikuko Motoike, Mika Watanabe, Kazuki Hayasaka, Akira Sakurada, Yoshinori Okada, Masayuki Yamamoto, Takashi Suzuki, Kengo Kinoshita, Hiroki Sekine, Hozumi Motohashi

Nature Communications　11　(1)　5911-5911　2020/12

DOI： 10.1038/s41467-020-19593-0 　

eISSN： 2041-1723

Nrf2 contributes to the weight gain of mice during space travel Peer-reviewed

Takafumi Suzuki, Akira Uruno, Akane Yumoto, Keiko Taguchi, Mikiko Suzuki, Nobuhiko Harada, Rie Ryoke, Eriko Naganuma, Nanae Osanai, Aya Goto, Hiromi Suda, Ryan Browne, Akihito Otsuki, Fumiki Katsuoka, Michael Zorzi, Takahiro Yamazaki, Daisuke Saigusa, Seizo Koshiba, Takashi Nakamura, Satoshi Fukumoto, Hironobu Ikehata, Keizo Nishikawa, Norio Suzuki, Ikuo Hirano, Ritsuko Shimizu, Tetsuya Oishi, Hozumi Motohashi, Hirona Tsubouchi, Risa Okada, Takashi Kudo, Michihiko Shimomura, Thomas W. Kensler, Hiroyasu Mizuno, Masaki Shirakawa, Satoru Takahashi, Dai Shiba, Masayuki Yamamoto

Communications Biology　3　(1)　496-496　2020/12

DOI： 10.1038/s42003-020-01227-2 　

eISSN： 2399-3642

Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors International-journal Peer-reviewed

Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto

Cancer Research　80　(16)　3331-3344　2020/08/15

DOI： 10.1158/0008-5472.can-19-2888 　

ISSN： 0008-5472

eISSN： 1538-7445

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. International-journal Peer-reviewed

Sisca Meida Wati, Daisuke Matsumaru, Hozumi Motohashi

Redox biology　36　101603-101603　2020/06/12

DOI： 10.1016/j.redox.2020.101603 　

硫化水素キノン酸化還元酵素(SQR)による硫化水素の解毒機構と生理機能の解明

松永 哲郎, 守田 匡伸, 西村 明, 井田 智章, 本橋 ほづみ, 赤池 孝章

日本衛生学雑誌　75　(Suppl.)　S193-S193　2020/03

ISSN： 0021-5082

eISSN： 1882-6482

Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites. International-journal Peer-reviewed

Daisuke Saigusa, Ikuko N Motoike, Sakae Saito, Michael Zorzi, Yuichi Aoki, Hiroshi Kitamura, Mikiko Suzuki, Fumiki Katsuoka, Hirofumi Ishii, Kengo Kinoshita, Hozumi Motohashi, Masayuki Yamamoto

Cancer science　111　(2)　667-678　2020/02

DOI： 10.1111/cas.14278 　

Study profile of The Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiro Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2020/01/11

DOI： 10.2188/jea.JE20190271 　

ISSN： 0917-5040

Erratum: Author Correction: Nrf2 contributes to the weight gain of mice during space travel (Communications biology (2020) 3 1 (496))

Suzuki, T., Uruno, A., Yumoto, A., Taguchi, K., Suzuki, M., Harada, N., Ryoke, R., Naganuma, E., Osanai, N., Goto, A., Suda, H., Browne, R., Otsuki, A., Katsuoka, F., Zorzi, M., Yamazaki, T., Saigusa, D., Koshiba, S., Nakamura, T., Fukumoto, S., Ikehata, H., Nishikawa, K., Suzuki, N., Hirano, I., Shimizu, R., Oishi, T., Motohashi, H., Tsubouchi, H., Okada, R., Kudo, T., Shimomura, M., Kensler, T.W., Mizuno, H., Shirakawa, M., Takahashi, S., Shiba, D., Yamamoto, M.

Communications biology　3　(1)　566-566　2020

DOI： 10.1038/s42003-020-01292-7 　

ISSN： 2399-3642

細菌のタンパク質翻訳共役型システインパースルフィド合成機構の解明

松永 哲郎, 井田 智章, 西村 明, ジョン・ミンギョン, 守田 匡伸, 澤 智裕, 居原 秀, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　75　(1)　118-118　2020/01

ISSN： 0021-4930

eISSN： 1882-4110

スルフィド 分裂酵母におけるキノン酸化還元酵素依存性エネルギー代謝(Sulfide: quinone oxidoreductase-dependent energy metabolism in fission yeast)

ザイ・ノルアビヂイン・カマルルハフィズ, 西村 明, 井田 智章, 守田 匡伸, ジョン・ミンギョン, 松永 哲郎, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌　75　(1)　70-70　2020/01

ISSN： 0021-4930

eISSN： 1882-4110

NADPH oxidaseによる活性硫黄代謝リモデリングと感染防御機構

井田 智章, 松永 哲郎, 守田 匡伸, 高田 剛, 本橋 ほづみ, 住本 英樹, 赤池 孝章

日本細菌学雑誌　75　(1)　96-96　2020/01

ISSN： 0021-4930

eISSN： 1882-4110

硫化水素キノン酸化還元酵素(SQR)によるミトコンドリアにおけるイオウ依存型エネルギー代謝機構の解明

松永 哲郎, 守田 匡伸, 西村 明, 井田 智章, 本橋 ほづみ, 赤池 孝章

日本生化学会大会プログラム・講演要旨集　92回　[3P-131]　2019/09

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International-journal Peer-reviewed

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　2019/08/25

DOI： 10.1093/ije/dyz169 　

ISSN： 0300-5771

Autophagy regulates lipid metabolism through selective turnover of NCoR1. International-journal Peer-reviewed

Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon-Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu

Nature communications　10　(1)　1567-1567　2019/04/05

DOI： 10.1038/s41467-019-08829-3 　

Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. International-journal Peer-reviewed

Mina Dodo, Hiroshi Kitamura, Hiroki Shima, Daisuke Saigusa, Sisca Meida Wati, Nao Ota, Fumiki Katsuoka, Hatsune Chiba, Hiroaki Okae, Takahiro Arima, Kazuhiko Igarashi, Takeyoshi Koseki, Hiroki Sekine, Hozumi Motohashi

Journal of biochemistry　165　(4)　323-334　2019/04/01

DOI： 10.1093/jb/mvy108 　

ISSN： 0021-924X

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response. International-journal Peer-reviewed

Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, Kumaki S, Miyazaki Y, Motohashi H, Yamamoto M, Tanaka N

Journal of immunology (Baltimore, Md. : 1950)　202　(5)　1331-1339　2019/03

DOI： 10.4049/jimmunol.1801180 　

ISSN： 0022-1767

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells Peer-reviewed

Shigemoto Fujii, Tomohiro Sawa, Hozumi Motohashi, Takaaki Akaike

British Journal of Pharmacology　176　(4)　607-615　2019/02

DOI： 10.1111/bph.14356 　

ISSN： 0007-1188

eISSN： 1476-5381

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis Peer-reviewed

Hisyam Abdul Hamid, Akira Tanaka, Tomoaki Ida, Akira Nishimura, Tetsuro Matsunaga, Shigemoto Fujii, Masanobu Morita, Tomohiro Sawa, Jon M. Fukuto, Péter Nagy, Ryouhei Tsutsumi, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike

Redox Biology　21　101096　2019/02

DOI： 10.1016/j.redox.2019.101096 　

ISSN： 2213-2317

Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells Peer-reviewed

Akira Nishimura, Ryo Nasuno, Yuki Yoshikawa, Minkyung Jung, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hiroshi Takagi, Hozumi Motohashi, Takaaki Akaike

Journal of Biological Chemistry　294　(37)　13781-13788　2019

DOI： 10.1074/jbc.RA119.009203 　

ISSN： 0021-9258

eISSN： 1083-351X

Tumors sweeten macrophages with acids. International-journal Peer-reviewed

Hiroki Sekine, Masayuki Yamamoto, Hozumi Motohashi

Nature immunology　19　(12)　1281-1283　2018/12

DOI： 10.1038/s41590-018-0258-0 　

ISSN： 1529-2908

Mitochondria-specific SQR deficiency in mice causes lethal impairment of sulfur respiration Peer-reviewed

Morita Masanobu, Ida Tomoaki, Tanaka Tomohiro, Matsunaga Tetsuro, Nishimura Akira, Fujii Shigemoto, Nishida Motohiro, Motohashi Hozumi, Akaike Takaaki

FREE RADICAL BIOLOGY AND MEDICINE　128　S90-S90　2018/11/20

DOI： 10.1016/j.freeradbiomed.2018.10.209 　

ISSN： 0891-5849

eISSN： 1873-4596

Scurfyマウスにおける全身性のNRF2活性化がもたらす炎症抑制作用の解析(Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice)

鈴木 琢磨, 村上 昌平, 張替 秀郎, 本橋 ほづみ

臨床血液　59　(9)　1515-1515　2018/09

ISSN： 0485-1439

eISSN： 1882-0824

O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1. International-journal Peer-reviewed

Hiroki Sekine, Keito Okazaki, Koichiro Kato, M Morshedul Alam, Hiroki Shima, Fumiki Katsuoka, Tadayuki Tsujita, Norio Suzuki, Akira Kobayashi, Kazuhiko Igarashi, Masayuki Yamamoto, Hozumi Motohashi

Molecular and cellular biology　38　(17)　2018/09/01

DOI： 10.1128/MCB.00252-18 　

ISSN： 0270-7306

硫化水素解毒酵素sulfide-quinone oxidoreductaseの機能解析

西村 明, 守田 匡伸, 南嶋 洋司, 井田 智章, 松永 哲郎, 藤井 重元, 本橋 ほづみ, 赤池 孝章

The Journal of Toxicological Sciences　43　(Suppl.)　S298-S298　2018/06

ISSN： 0388-1350

eISSN： 1880-3989

Cysteinyl-tRNA synthetase (CARS) controls endogenous hydropersulfide production and mitochondrial respiration Peer-reviewed

Akaike Takaaki, Motohashi Hozumi, Fukuto Jon, Nagy Peter

FREE RADICAL BIOLOGY AND MEDICINE　120　S21　2018/05/20

DOI： 10.1016/j.freeradbiomed.2018.04.087 　

ISSN： 0891-5849

Bright and dark sides of KEAP1-NRF2 system in carcinogenesis Peer-reviewed

Motohashi Hozumi, Ida Tomoaki, Alam Md. Morshedul, Kitamura Hiroshi, Akaike Takaaki

FREE RADICAL BIOLOGY AND MEDICINE　120　S18　2018/05/20

DOI： 10.1016/j.freeradbiomed.2018.04.078 　

ISSN： 0891-5849

Nucleomethylin deficiency impairs embryonic erythropoiesis. International-journal Peer-reviewed

Shohei Murakami, Takuma Suzuki, Wataru Yokoyama, Satoko Yagi, Keita Matsumura, Yuka Nakajima, Hideo Harigae, Akiyoshi Fukamizu, Hozumi Motohashi

Journal of biochemistry　163　(5)　413-423　2018/05/01

DOI： 10.1093/jb/mvx086 　

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo Peer-reviewed

Eiki Yoshida, Takafumi Suzuki, Masanobu Morita, Keiko Taguchi, Kohei Tsuchida, Hozumi Motohashi, Minoru Doita, Masayuki Yamamoto

Genes to Cells　23　(5)　386-392　2018/05/01

DOI： 10.1111/gtc.12579 　

ISSN： 1365-2443 1356-9597

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. International-journal Peer-reviewed

Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Masaaki Kawai, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi I Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo, Nobuhiro Tanuma

Cancer cell　33　(3)　355-367　2018/03/12

DOI： 10.1016/j.ccell.2018.02.004 　

A novel cysteine persulfide synthase potentially contributing to electrophile detoxification

IDA Tomoaki, AKAIKE Takaaki, MORITA Masanobu, NISHIMURA Akira, MATSUNAGA Tetsuro, IHARA Hideshi, SAWA Tomohiro, FUJII Shigemoto, KUMAGAI Yoshito, MOTOHASHI Hozumi

Annual Meeting of the Japanese Society of Toxicology　45　(0)　P-178　2018

DOI： 10.14869/toxpt.45.1.0_P-178 　

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding Peer-reviewed

Kanamoto, M., Tsuchiya, Y., Nakao, Y., Suzuki, T., Motohashi, H., Yamamoto, M., Kamata, H.

PLoS ONE　13　(11)　e0203978　2018

DOI： 10.1371/journal.pone.0203978 　

ISSN： 1932-6203

NRF2依存性難治がんの成立機構とその特性 Invited Peer-reviewed

北村大志, 本橋ほづみ

実験医学　36　(5)　809-814　2018

レドックス疾患学：レドックス制御の破綻による病態と新たな疾患概念 Invited Peer-reviewed

本橋ほづみ, 赤池孝章, 内田浩二, 末松誠

実験医学　36　(5)　642-648　2018

ISSN： 0288-5514

KEAP1-NRF2制御系による酸化ストレス応答と抗老化作用 Invited Peer-reviewed

本橋ほづみ

実験医学　35　(20)　3369-3373　2017/12

Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases Peer-reviewed

Tomoaki Ida, Akira Nishimura, Masanobu Morita, Hozumi Motohashi, Takaaki Akaike

FREE RADICAL BIOLOGY AND MEDICINE　112　189-190　2017/11

DOI： 10.1016/j.freeradbiomed.2017.10.297 　

ISSN： 0891-5849

eISSN： 1873-4596

Moonlighting Functions of Cysteinyl-tRNA Synthetases: Cycteine Hydropersulfide Production and Regulation of Mitochondrial Biogenesis and Bioenergetics Peer-reviewed

Takaaki Akaike, Akira Nishimura, Tomoaki Ida, Tetsuro Matsunaga, Masanobu Morita, Hozumi Motohashi

FREE RADICAL BIOLOGY AND MEDICINE　112　182-183　2017/11

DOI： 10.1016/j.freeradbiomed.2017.10.284 　

ISSN： 0891-5849

eISSN： 1873-4596

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model Peer-reviewed

H. Kitamura, Y. Onodera, S. Murakami, T. Suzuki, H. Motohashi

ONCOGENE　36　(45)　6315-6324　2017/11

DOI： 10.1038/onc.2017.236 　

ISSN： 0950-9232

eISSN： 1476-5594

Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau Peer-reviewed

Taiki Shimizu, Chiyoko Uchida, Ritsuko Shimizu, Hozumi Motohashi, Takafumi Uchida

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　493　(2)　946-951　2017/11

DOI： 10.1016/j.bbrc.2017.09.115 　

ISSN： 0006-291X

eISSN： 1090-2104

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. International-journal Peer-reviewed

Takaaki Akaike, Tomoaki Ida, Fan-Yan Wei, Motohiro Nishida, Yoshito Kumagai, Md Morshedul Alam, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Satoshi Watanabe, Kenji Inaba, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, Masaki Ohmuraya, Péter Nagy, Martin Feelisch, Jon M Fukuto, Hozumi Motohashi

Nature communications　8　(1)　1177-1177　2017/10/27

DOI： 10.1038/s41467-017-01311-y 　

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells Peer-reviewed

Shohei Murakami, Takuma Suzuki, Hideo Harigae, Paul-Henri Romeo, Masayuki Yamamoto, Hozumi Motohashi

MOLECULAR AND CELLULAR BIOLOGY　37　(19)　pii: e00086-17-pii: e00086-17　2017/10

DOI： 10.1128/MCB.00086-17 　

ISSN： 0270-7306

eISSN： 1098-5549

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells Peer-reviewed

Sarah Rodrigues-Moreira, Stephanie G. Moreno, Giulia Ghinatti, Daniel Lewandowski, Francoise Hoffschir, Federica Ferri, Anne-Sophie Gallouet, Denise Gay, Hozumi Motohashi, Masayuki Yamamoto, Michael C. Joiner, Nathalie Gault, Paul-Henri Romeo

CELL REPORTS　20　(13)　3199-3211　2017/09

DOI： 10.1016/j.celrep.2017.09.013 　

ISSN： 2211-1247

FANTOM5 CAGE profiles of human and mouse samples. International-journal Peer-reviewed

Shuhei Noguchi, Takahiro Arakawa, Shiro Fukuda, Masaaki Furuno, Akira Hasegawa, Fumi Hori, Sachi Ishikawa-Kato, Kaoru Kaida, Ai Kaiho, Mutsumi Kanamori-Katayama, Tsugumi Kawashima, Miki Kojima, Atsutaka Kubosaki, Ri-Ichiroh Manabe, Mitsuyoshi Murata, Sayaka Nagao-Sato, Kenichi Nakazato, Noriko Ninomiya, Hiromi Nishiyori-Sueki, Shohei Noma, Eri Saijyo, Akiko Saka, Mizuho Sakai, Christophe Simon, Naoko Suzuki, Michihira Tagami, Shoko Watanabe, Shigehiro Yoshida, Peter Arner, Richard A Axton, Magda Babina, J Kenneth Baillie, Timothy C Barnett, Anthony G Beckhouse, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, Ailsa J Carlisle, Hans C Clevers, Carrie A Davis, Michael Detmar, Taeko Dohi, Albert S B Edge, Matthias Edinger, Anna Ehrlund, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Afsaneh Eslami, Michela Fagiolini, Lynsey Fairbairn, Mary C Farach-Carson, Geoffrey J Faulkner, Carmelo Ferrai, Malcolm E Fisher, Lesley M Forrester, Rie Fujita, Jun-Ichi Furusawa, Teunis B Geijtenbeek, Thomas Gingeras, Daniel Goldowitz, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Yuki Hasegawa, Meenhard Herlyn, Peter Heutink, Kelly J Hitchens, David A Hume, Tomokatsu Ikawa, Yuri Ishizu, Chieko Kai, Hiroshi Kawamoto, Yuki I Kawamura, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, Sarah Klein, S Peter Klinken, Alan J Knox, Soichi Kojima, Haruhiko Koseki, Shigeo Koyasu, Weonju Lee, Andreas Lennartsson, Alan Mackay-Sim, Niklas Mejhert, Yosuke Mizuno, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Kelly J Morris, Hozumi Motohashi, Christine L Mummery, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Tadasuke Nozaki, Soichi Ogishima, Naganari Ohkura, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Robert Passier, Margaret Patrikakis, Ana Pombo, Swati Pradhan-Bhatt, Xian-Yang Qin, Michael Rehli, Patrizia Rizzu, Sugata Roy, Antti Sajantila, Shimon Sakaguchi, Hiroki Sato, Hironori Satoh, Suzana Savvi, Alka Saxena, Christian Schmidl, Claudio Schneider, Gundula G Schulze-Tanzil, Anita Schwegmann, Guojun Sheng, Jay W Shin, Daisuke Sugiyama, Takaaki Sugiyama, Kim M Summers, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Andru Tomoiu, Hiroo Toyoda, Marc van de Wetering, Linda M van den Berg, Roberto Verardo, Dipti Vijayan, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Yoko Yamaguchi, Masayuki Yamamoto, Chiyo Yanagi-Mizuochi, Misako Yoneda, Yohei Yonekura, Peter G Zhang, Silvia Zucchelli, Imad Abugessaisa, Erik Arner, Jayson Harshbarger, Atsushi Kondo, Timo Lassmann, Marina Lizio, Serkan Sahin, Thierry Sengstag, Jessica Severin, Hisashi Shimoji, Masanori Suzuki, Harukazu Suzuki, Jun Kawai, Naoto Kondo, Masayoshi Itoh, Carsten O Daub, Takeya Kasukawa, Hideya Kawaji, Piero Carninci, Alistair R R Forrest, Yoshihide Hayashizaki

Scientific data　4　170112-170112　2017/08/29

DOI： 10.1038/sdata.2017.112 　

ISSN： 2052-4463

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells Peer-reviewed

Motohiro Nishida, Akiyuki Nishimura, Tetsuro Matsunaga, Hozumi Motohashi, Shingo Kasamatsu, Takaaki Akaike

FREE RADICAL BIOLOGY AND MEDICINE　109　132-140　2017/08

DOI： 10.1016/j.freeradbiomed.2017.01.024 　

ISSN： 0891-5849

eISSN： 1873-4596

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice Peer-reviewed

Takuma Suzuki, Shohei Murakami, Shyam S. Biswal, Shimon Sakaguchi, Hideo Harigae, Masayuki Yamamoto, Hozumi Motohashi

MOLECULAR AND CELLULAR BIOLOGY　37　(15)　pii: e00063-17-pii: e00063-17　2017/08

DOI： 10.1128/MCB.00063-17 　

ISSN： 0270-7306

eISSN： 1098-5549

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2. International-journal Peer-reviewed

Md Morshedul Alam, Keito Okazaki, Linh Thi Thao Nguyen, Nao Ota, Hiroshi Kitamura, Shohei Murakami, Hiroki Shima, Kazuhiko Igarashi, Hiroki Sekine, Hozumi Motohashi

The Journal of biological chemistry　292　(18)　7519-7530　2017/05/05

DOI： 10.1074/jbc.M116.773960 　

環境応答の転写制御シグナル―KEAP1-NRF2制御系― Invited Peer-reviewed

鈴木琢磨, 本橋ほづみ

最新医学　72　(5)　703-709　2017/05

ISSN： 0370-8241

Nrf2はNALP3インフラマソーム活性化を介して黄色ブドウ球菌感染を制御する(Nrf2 regulates Staphylococcus aureus infection through NLRP3 inflammasome activation)

長島 隆一, 小齋 仁美, 小嶋 克彦, 竹下 敏一, 本橋 ほづみ, 山本 雅之, 田中 伸幸

日本細菌学雑誌　72　(1)　154-154　2017/02

ISSN： 0021-4930

eISSN： 1882-4110

細菌のイオウ呼吸はすべての生物種に保存されている ほ乳類における新しいエネルギー代謝経路・イオウ呼吸の発見

赤池 孝章, 井田 智章, 松永 哲郎, 守田 匡伸, 笠松 真吾, 西村 明, 藤井 重元, 居原 秀, ジョン・ミンギョン, 赤司 壮一郎, 澤 智裕, 本橋 ほづみ

日本細菌学雑誌　72　(1)　98-98　2017/02

ISSN： 0021-4930

eISSN： 1882-4110

Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1 Peer-reviewed

Minkyung Jung, Shingo Kasamatsu, Tetsuro Matsunaga, Soichiro Akashi, Katsuhiko Ono, Akira Nishimura, Masanobu Morita, Hisyam Abdul Hamid, Shigemoto Fujii, Hiroshi Kitamura, Tomohiro Sawa, Tomoaki Ida, Hozumi Motohashi, Takaaki Akaike

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　480　(2)　180-186　2016/11

DOI： 10.1016/j.bbrc.2016.10.022 　

ISSN： 0006-291X

eISSN： 1090-2104

2-ヒドロキシグルタル酸の精子形成・胎児発生における生理的役割の検討

百々 美奈, 北村 大志, 太田 奈緒, 三枝 大輔, 勝岡 史城, 千葉 初音, 岡江 寛明, 有馬 隆博, 小関 健由, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　89回　[3P-165]　2016/09

細胞のロバストネスを規定するタンパク質複合体のダイナミクス 活性型PI3K-AKTシグナル伝達の存在下と非存在下における内因性NRF2複合体の精製と分析(Purification and analysis of endogenous NRF2 complex in the presence and absence of active PI3K-AKT signaling)

本橋 ほづみ, 太田 奈緒, 島 弘季, 五十嵐 和彦, 関根 弘樹

日本生化学会大会プログラム・講演要旨集　89回　[2S12-5]　2016/09

転写因子NRF1のOGT-HCF-1複合体を介した分解制御機構 Peer-reviewed

関根 弘樹, 加藤 幸一郎, 福田 愛菜, 鈴木 教郎, 岡崎 慶斗, アラム・モルシェッド, 辻田 忠志, 小林 聡, 山本 雅之, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　89回　[3P-111]　2016/09

Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin Peer-reviewed

Hayato Irokawa, Tsuyoshi Tachibana, Toshihiko Watanabe, Yuka Matsuyama, Hozumi Motohashi, Ayako Ogasawara, Kenta Iwai, Akira Naganuma, Shusuke Kuge

SCIENTIFIC REPORTS　6　33536-33536　2016/09

DOI： 10.1038/srep33536 　

ISSN： 2045-2322

The structural origin of metabolic quantitative diversity Peer-reviewed

Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, Matsuyuki Shirota, Tomo Saito, Daisuke Saigusa, Inaho Danjoh, Fumiki Katsuoka, Soichi Ogishima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Miyuki Sakurai, Sachiko Hirano, Junichi Nakata, Hozumi Motohashi, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Yoichi Suzuki, Shigeo Kure, Nobuo Yaegashi, Osamu Tanabe, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

SCIENTIFIC REPORTS　6　31463-31463　2016/08

DOI： 10.1038/srep31463 　

ISSN： 2045-2322

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery Peer-reviewed

Daisuke Saigusa, Yasunobu Okamura, Ikuko N. Motoike, Yasutake Katoh, Yasuhiro Kurosawa, Reina Saijyo, Seizo Koshiba, Jun Yasuda, Hozumi Motohashi, Junichi Sugawara, Osamu Tanabe, Kengo Kinoshita, Masayuki Yamamoto

PLOS ONE　11　(8)　e0160555-e0160555　2016/08

DOI： 10.1371/journal.pone.0160555 　

ISSN： 1932-6203

CD271 regulates the proliferation and motility of hypopharyngeal cancer cells Peer-reviewed

Mai Mochizuki, Keiichi Tamai, Takayuki Imai, Sayuri Sugawara, Naoko Ogama, Mao Nakamura, Kazuto Matsuura, Kazunori Yamaguchi, Kennichi Satoh, Ikuro Sato, Hozumi Motohashi, Kazuo Sugamura, Nobuyuki Tanaka

SCIENTIFIC REPORTS　6　31463-31463　2016/07

DOI： 10.1038/srep30707 　

ISSN： 2045-2322

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Peer-reviewed

Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata, Daisuke Yasuda, Kyoko Takahashi, Tsutomu Fujimura, Jingbo Pi, Myung-Shik Lee, Takashi Ueno, Tomoyuki Ohe, Tadahiko Mashino, Toshifumi Wakai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hozumi Motohashi, Satoshi Waguri, Tomoyoshi Soga, Masayuki Yamamoto, Keiji Tanaka, Masaaki Komatsu

NATURE COMMUNICATIONS　7　12030-12030　2016/06

DOI： 10.1038/ncomms12030 　

ISSN： 2041-1723

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. International-journal Peer-reviewed

Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama, Masayuki Yamamoto

Nature communications　7　11624-11624　2016/05/23

DOI： 10.1038/ncomms11624 　

過酸化水素の感知と代謝制御におけるペルオキシレドキシンの新機能

色川 隼人, 松山 由香, 本橋 ほづみ, 岩井 健太, 久下 周佐

日本薬学会年会要旨集　136年会　(3)　90-90　2016/03

ISSN： 0918-9823

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. International-journal Peer-reviewed

Hiroki Sekine, Keito Okazaki, Nao Ota, Hiroki Shima, Yasutake Katoh, Norio Suzuki, Kazuhiko Igarashi, Mitsuhiro Ito, Hozumi Motohashi, Masayuki Yamamoto

Molecular and cellular biology　36　(3)　407-20　2016/02/01

DOI： 10.1128/MCB.00785-15 　

Erratum: MAFG is a transcriptional repressor of bile acid synthesis and metabolism (Cell Metabolism (2015) 21 (298-310))

De Aguiar Vallim, T.Q.D.A., Tarling, E.J., Ahn, H., Hagey, L.R., Romanoski, C.E., Lee, R.G., Graham, M.J., Motohashi, H., Yamamoto, M., Edwards, P.A.

Cell Metabolism　23　(3)　563-563　2016

DOI： 10.1016/j.cmet.2016.02.006 　

ISSN： 1932-7420 1550-4131

酸化ストレス応答転写因子NRF2の転写制御機構 Invited Peer-reviewed

関根弘樹, 本橋ほづみ

実験医学　34　2517-2524　2016

Recent advances in elucidating KEAP1-NRF2 functions in hematopoietic/immune cells and leukemic cells Invited Peer-reviewed

Murakami, S., Motohashi, H.

[Rinsho ketsueki] The Japanese journal of clinical hematology　57　(10)　1860-1868　2016

DOI： 10.11406/rinketsu.57.1860 　

ISSN： 0485-1439

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea Peer-reviewed

Yohei Honkura, Hirotaka Matsuo, Shohei Murakami, Masayuki Sakiyama, Kunio Mizutari, Akihiro Shiotani, Masayuki Yamamoto, Ichiro Morita, Nariyoshi Shinomiya, Tetsuaki Kawase, Yukio Katori, Hozumi Motohashi

SCIENTIFIC REPORTS　6　19329-19329　2016/01

DOI： 10.1038/srep19329 　

ISSN： 2045-2322

The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization Peer-reviewed

Ryo Ando, Hiroki Shima, Toru Tamahara, Yoshihiro Sato, Miki Watanabe-Matsui, Hiroki Kato, Nicolas Sax, Hozumi Motohashi, Keiko Taguchi, Masayuki Yamamoto, Masaki Nio, Tatsuya Maeda, Kyoko Ochiai, Akihiko Muto, Kazuhiko Igarashi

JOURNAL OF BIOLOGICAL CHEMISTRY　291　(4)　1826-1840　2016/01

DOI： 10.1074/jbc.M115.661702 　

ISSN： 0021-9258

eISSN： 1083-351X

Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation Peer-reviewed

Arif Santoso, Toshiaki Kikuchi, Naoki Tode, Taizou Hirano, Riyo Komatsu, Triya Damayanti, Hozumi Motohashi, Masayuki Yamamoto, Tetsuhito Kojima, Toshimitsu Uede, Toshihiro Nukiwa, Masakazu Ichinose

MOLECULAR THERAPY　24　(1)　41-52　2016/01

DOI： 10.1038/mt.2015.153 　

ISSN： 1525-0016

eISSN： 1525-0024

頭頸部癌におけるCD271の機能性

望月 麻衣, 玉井 圭一, 山口 壹範, 今井 隆之, 佐藤 賢一, 松浦 一登, 小鎌 直子, 中村 真央, 本橋 ほづみ, 菅村 和夫, 田中 伸幸

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[1P1058]-[1P1058]　2015/12

NRF2-MED16を介した抗酸化遺伝子群の転写活性化機構 Peer-reviewed

岡崎 慶斗, 関根 弘樹, 鈴木 教郎, 加藤 恭丈, 五十嵐 和彦, 伊藤 光宏, 本橋 ほづみ, 山本 雅之

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[4T14L-01(3P0701)]　2015/12

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1 Peer-reviewed

Akihiro Ito, Tadahiro Shimazu, Satoko Maeda, Asad Ali Shah, Tatsuhiko Tsunoda, Shun-ichiro Iemura, Toru Natsume, Takafumi Suzuki, Hozumi Motohashi, Masayuki Yamamoto, Minoru Yoshida

SCIENCE SIGNALING　8　(404)　ra120-ra120　2015/11

DOI： 10.1126/scisignal.aad0667 　

ISSN： 1945-0877

eISSN： 1937-9145

Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice Peer-reviewed

Makiko Hayashi, Jun Takai, Lei Yu, Hozumi Motohashi, Takashi Moriguchi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　35　(20)　3590-3601　2015/10

DOI： 10.1128/MCB.00506-15 　

ISSN： 0270-7306

eISSN： 1098-5549

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo Peer-reviewed

Chiharu Ota, Mitsuhiro Yamada, Naoya Fujino, Hozumi Motohashi, Yukiko Tando, Yusuke Takei, Takaya Suzuki, Toru Takahashi, Satoshi Kamata, Tomonori Makiguchi, Mutsuo Yamaya, Hiroshi Kubo

EXPERIMENTAL LUNG RESEARCH　41　(8)　422-434　2015/09

DOI： 10.3109/01902148.2015.1060275 　

ISSN： 0190-2148

eISSN： 1521-0499

Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract Peer-reviewed

Smriti A. Agrawal, Deepti Anand, Archana D. Siddam, Atul Kakrana, Soma Dash, David A. Scheiblin, Christine A. Dang, Anne M. Terrell, Stephanie M. Waters, Abhyudai Singh, Hozumi Motohashi, Masayuki Yamamoto, Salil A. Lachke

HUMAN GENETICS　134　(7)　717-735　2015/07

DOI： 10.1007/s00439-015-1554-5 　

ISSN： 0340-6717

eISSN： 1432-1203

Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis Peer-reviewed

Maki Goto, Hiroshi Kitamura, Md Morshedul Alam, Nao Ota, Takeshi Haseba, Toshio Akimoto, Akio Shimizu, Teruko Takano-Yamamoto, Masayuki Yamamoto, Hozumi Motohashi

GENES TO CELLS　20　(6)　464-480　2015/06

DOI： 10.1111/gtc.12237 　

ISSN： 1356-9597

eISSN： 1365-2443

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. International-journal Peer-reviewed

Kimura M, Yamamoto T, Zhang J, Itoh K, Kyo M, Kamiya T, Aburatani H, Katsuoka F, Kurokawa H, Tanaka T, Motohashi H, Yamamoto M

The Journal of biological chemistry　290　(17)　10644-10644　2015/04

DOI： 10.1074/jbc.A115.706863 　

ISSN： 0021-9258

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients Peer-reviewed

Masayuki Kanamori, Tsuyoshi Higa, Yukihiko Sonoda, Shohei Murakami, Mina Dodo, Hiroshi Kitamura, Keiko Taguchi, Tatsuhiro Shibata, Mika Watanabe, Hiroyoshi Suzuki, Ichiyo Shibahara, Ryuta Saito, Yoji Yamashita, Toshihiro Kumabe, Masayuki Yamamoto, Hozumi Motohashi, Teiji Tominaga

NEURO-ONCOLOGY　17　(4)　555-565　2015/04

DOI： 10.1093/neuonc/nou282 　

ISSN： 1522-8517

eISSN： 1523-5866

質量分析技術を基盤とした超高感度分析手法の革新 LC-MSによる微量組織切片中リゾリン脂質の分析

三枝 大輔, 奥平 倫世, Wang Jiao, 可野 邦之, Baasanjav Uranbileg, 蔵野 信, 池田 均, 矢冨 裕, 青木 淳賢, 本橋 ほづみ

日本薬学会年会要旨集　135年会　(1)　132-132　2015/03

ISSN： 0918-9823

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism Peer-reviewed

Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling, Hannah Ahn, Lee R. Hagey, Casey E. Romanoski, Richard G. Lee, Mark J. Graham, Hozumi Motohashi, Masayuki Yamamoto, Peter A. Edwards

CELL METABOLISM　21　(2)　298-310　2015/02

DOI： 10.1016/j.cmet.2015.01.007 　

ISSN： 1550-4131

eISSN： 1932-7420

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

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PLoS Biology　13　(12)　2015

DOI： 10.1371/journal.pbio.1002315 　

ISSN： 1545-7885 1544-9173

巨核球分化と遺伝子発現・調節 Invited Peer-reviewed

本橋ほづみ

Thrombosis Medicine　5　(2)　113-118　2015

ISSN： 2186-0327

NRF2による転写制御機構と細胞の分化・増殖・がん化における貢献 Invited Peer-reviewed

関根弘樹, 本橋ほづみ

医学のあゆみ　2015

非小細胞性肺癌におけるKEAP1-NRF2システム Invited Peer-reviewed

光石陽一郎, 本橋ほづみ

Annual Review 2015 呼吸器　119-126　2015

Metabolism of 8-nitro-cGMP and regulation of electrophilic signaling by reactive sulfur species Peer-reviewed

Ida Tomoaki, Sawa Tomohiro, Ihara Hideshi, Tsuchiya Yukihiro, Watanabe Yasuo, Kumagai Yoshito, Motohashi Hozumi, Fujii Shigemoto, Matsunaga Tetsuro, Yamamoto Masayuki, Ono Katsuhiko, Fukuto Jon, Akaike Takaaki

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　42　126-127　2014/11/15

DOI： 10.1016/j.niox.2014.09.084 　

ISSN： 1089-8603

eISSN： 1089-8611

ペルオキシレドキシンによるピルビン酸キナーゼの活性制御は代謝変化および酸化ストレス応答に寄与する

色川 隼人, 松山 由香, 本橋 ほづみ, 岩井 健太, 久下 周佐

日本生化学会大会プログラム・講演要旨集　87回　[4T16a-03]　2014/10

Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM Peer-reviewed

Kazumi Hirano, Takaaki Kinoshita, Takeshi Uemura, Hozumi Motohashi, Yohei Watanabe, Tatsuhiko Ebihara, Hidetoshi Nishiyama, Mari Sato, Mitsuo Suga, Yuusuke Maruyama, Noriko M. Tsuji, Masayuki Yamamoto, Shoko Nishihara, Chikara Sato

ULTRAMICROSCOPY　143　52-66　2014/08

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eISSN： 1879-2723

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice Peer-reviewed

Yosuke Hirotsu, Chika Higashi, Toshiaki Fukutomi, Fumiki Katsuoka, Tadayuki Tsujita, Yoko Yagishita, Yuka Matsuyama, Hozumi Motohashi, Akira Uruno, Masayuki Yamamoto

GENES TO CELLS　19　(8)　650-665　2014/08

DOI： 10.1111/gtc.12165 　

ISSN： 1356-9597

eISSN： 1365-2443

NF-E2-Related Factor 2 Promotes Compensatory Liver Hypertrophy After Portal Vein Branch Ligation in Mice Peer-reviewed

Keiichi Shirasaki, Keiko Taguchi, Michiaki Unno, Hozumi Motohashi, Masayuki Yamamoto

HEPATOLOGY　59　(6)　2371-2382　2014/06

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eISSN： 1527-3350

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. International-journal Peer-reviewed

Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Yoshito Kumagai, Makoto Suematsu, Hozumi Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, Katsuhiko Ono, Nelmi O Devarie-Baez, Ming Xian, Jon M Fukuto, Takaaki Akaike

Proceedings of the National Academy of Sciences of the United States of America　111　(21)　7606-11　2014/05/27

DOI： 10.1073/pnas.1321232111 　

NRF2 immunolocalization in human breast cancer patients as a prognostic factor Peer-reviewed

Yoshiaki Onodera, Hozumi Motohashi, Kiyoshi Takagi, Yasuhiro Miki, Yukiko Shibahara, Mika Watanabe, Takanori Ishida, Hisashi Hirakawa, Hironobu Sasano, Masayuki Yamamoto, Takashi Suzuki

ENDOCRINE-RELATED CANCER　21　(2)　241-252　2014/04

DOI： 10.1530/ERC-13-0234 　

ISSN： 1351-0088

eISSN： 1479-6821

A promoter-level mammalian expression atlas. International-journal Peer-reviewed

Alistair R R Forrest, Hideya Kawaji, Michael Rehli, J Kenneth Baillie, Michiel J L de Hoon, Vanja Haberle, Timo Lassmann, Ivan V Kulakovskiy, Marina Lizio, Masayoshi Itoh, Robin Andersson, Christopher J Mungall, Terrence F Meehan, Sebastian Schmeier, Nicolas Bertin, Mette Jørgensen, Emmanuel Dimont, Erik Arner, Christian Schmidl, Ulf Schaefer, Yulia A Medvedeva, Charles Plessy, Morana Vitezic, Jessica Severin, Colin A Semple, Yuri Ishizu, Robert S Young, Margherita Francescatto, Intikhab Alam, Davide Albanese, Gabriel M Altschuler, Takahiro Arakawa, John A C Archer, Peter Arner, Magda Babina, Sarah Rennie, Piotr J Balwierz, Anthony G Beckhouse, Swati Pradhan-Bhatt, Judith A Blake, Antje Blumenthal, Beatrice Bodega, Alessandro Bonetti, James Briggs, Frank Brombacher, A Maxwell Burroughs, Andrea Califano, Carlo V Cannistraci, Daniel Carbajo, Yun Chen, Marco Chierici, Yari Ciani, Hans C Clevers, Emiliano Dalla, Carrie A Davis, Michael Detmar, Alexander D Diehl, Taeko Dohi, Finn Drabløs, Albert S B Edge, Matthias Edinger, Karl Ekwall, Mitsuhiro Endoh, Hideki Enomoto, Michela Fagiolini, Lynsey Fairbairn, Hai Fang, Mary C Farach-Carson, Geoffrey J Faulkner, Alexander V Favorov, Malcolm E Fisher, Martin C Frith, Rie Fujita, Shiro Fukuda, Cesare Furlanello, Masaaki Furino, Jun-ichi Furusawa, Teunis B Geijtenbeek, Andrew P Gibson, Thomas Gingeras, Daniel Goldowitz, Julian Gough, Sven Guhl, Reto Guler, Stefano Gustincich, Thomas J Ha, Masahide Hamaguchi, Mitsuko Hara, Matthias Harbers, Jayson Harshbarger, Akira Hasegawa, Yuki Hasegawa, Takehiro Hashimoto, Meenhard Herlyn, Kelly J Hitchens, Shannan J Ho Sui, Oliver M Hofmann, Ilka Hoof, Furni Hori, Lukasz Huminiecki, Kei Iida, Tomokatsu Ikawa, Boris R Jankovic, Hui Jia, Anagha Joshi, Giuseppe Jurman, Bogumil Kaczkowski, Chieko Kai, Kaoru Kaida, Ai Kaiho, Kazuhiro Kajiyama, Mutsumi Kanamori-Katayama, Artem S Kasianov, Takeya Kasukawa, Shintaro Katayama, Sachi Kato, Shuji Kawaguchi, Hiroshi Kawamoto, Yuki I Kawamura, Tsugumi Kawashima, Judith S Kempfle, Tony J Kenna, Juha Kere, Levon M Khachigian, Toshio Kitamura, S Peter Klinken, Alan J Knox, Miki Kojima, Soichi Kojima, Naoto Kondo, Haruhiko Koseki, Shigeo Koyasu, Sarah Krampitz, Atsutaka Kubosaki, Andrew T Kwon, Jeroen F J Laros, Weonju Lee, Andreas Lennartsson, Kang Li, Berit Lilje, Leonard Lipovich, Alan Mackay-Sim, Ri-ichiroh Manabe, Jessica C Mar, Benoit Marchand, Anthony Mathelier, Niklas Mejhert, Alison Meynert, Yosuke Mizuno, David A de Lima Morais, Hiromasa Morikawa, Mitsuru Morimoto, Kazuyo Moro, Efthymios Motakis, Hozumi Motohashi, Christine L Mummery, Mitsuyoshi Murata, Sayaka Nagao-Sato, Yutaka Nakachi, Fumio Nakahara, Toshiyuki Nakamura, Yukio Nakamura, Kenichi Nakazato, Erik van Nimwegen, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Shohei Noma, Tadasuke Noazaki, Soichi Ogishima, Naganari Ohkura, Hiroko Ohimiya, Hiroshi Ohno, Mitsuhiro Ohshima, Mariko Okada-Hatakeyama, Yasushi Okazaki, Valerio Orlando, Dmitry A Ovchinnikov, Arnab Pain, Robert Passier, Margaret Patrikakis, Helena Persson, Silvano Piazza, James G D Prendergast, Owen J L Rackham, Jordan A Ramilowski, Mamoon Rashid, Timothy Ravasi, Patrizia Rizzu, Marco Roncador, Sugata Roy, Morten B Rye, Eri Saijyo, Antti Sajantila, Akiko Saka, Shimon Sakaguchi, Mizuho Sakai, Hiroki Sato, Suzana Savvi, Alka Saxena, Claudio Schneider, Erik A Schultes, Gundula G Schulze-Tanzil, Anita Schwegmann, Thierry Sengstag, Guojun Sheng, Hisashi Shimoji, Yishai Shimoni, Jay W Shin, Christophe Simon, Daisuke Sugiyama, Takaai Sugiyama, Masanori Suzuki, Naoko Suzuki, Rolf K Swoboda, Peter A C 't Hoen, Michihira Tagami, Naoko Takahashi, Jun Takai, Hiroshi Tanaka, Hideki Tatsukawa, Zuotian Tatum, Mark Thompson, Hiroo Toyodo, Tetsuro Toyoda, Elvind Valen, Marc van de Wetering, Linda M van den Berg, Roberto Verado, Dipti Vijayan, Ilya E Vorontsov, Wyeth W Wasserman, Shoko Watanabe, Christine A Wells, Louise N Winteringham, Ernst Wolvetang, Emily J Wood, Yoko Yamaguchi, Masayuki Yamamoto, Misako Yoneda, Yohei Yonekura, Shigehiro Yoshida, Susan E Zabierowski, Peter G Zhang, Xiaobei Zhao, Silvia Zucchelli, Kim M Summers, Harukazu Suzuki, Carsten O Daub, Jun Kawai, Peter Heutink, Winston Hide, Tom C Freeman, Boris Lenhard, Vladimir B Bajic, Martin S Taylor, Vsevolod J Makeev, Albin Sandelin, David A Hume, Piero Carninci, Yoshihide Hayashizaki

Nature　507　(7493)　462-70　2014/03/27

DOI： 10.1038/nature13182 　

ISSN： 0028-0836

Hematopoietic Stem and Progenitor Cell Activation During Chronic Dermatitis Provoked by Constitutively Active Aryl-Hydrocarbon Receptor Driven by Keratin 14 Promoter Peer-reviewed

Shohei Murakami, Masayuki Yamamoto, Hozumi Motohashi

TOXICOLOGICAL SCIENCES　138　(1)　47-58　2014/03

DOI： 10.1093/toxsci/kft273 　

ISSN： 1096-6080

eISSN： 1096-0929

Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells Peer-reviewed

Shohei Murakami, Ritsuko Shimizu, Paul-Henri Romeo, Masayuki Yamamoto, Hozumi Motohashi

GENES TO CELLS　19　(3)　239-253　2014/03

DOI： 10.1111/gtc.12126 　

ISSN： 1356-9597

eISSN： 1365-2443

Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers Peer-reviewed

Keiko Taguchi, Ikuo Hirano, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Akira Suzuki, Hozumi Motohashi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　34　(5)　900-913　2014/03

DOI： 10.1128/MCB.01384-13 　

ISSN： 0270-7306

eISSN： 1098-5549

Simultaneous Quantification of Sphingolipids in Small Quantities of Liver by LC-MS/MS. Peer-reviewed

Daisuke Saigusa, Michiyo Okudaira, Jiao Wang, Kuniyuki Kano, Makoto Kurano, Baasanjav Uranbileg, Hitoshi Ikeda, Yutaka Yatomi, Hozumi Motohashi, Junken Aoki

Mass spectrometry (Tokyo, Japan)　3　(Spec Iss 3)　S0046　2014

DOI： 10.5702/massspectrometry.S0046 　

ISSN： 2187-137X

Nrf2制御系とAdh3の協調作用による生体防御機構の解析 Peer-reviewed

後藤 まき, 長谷場 健, 鈴木 教郎, 山本 雅之, 山本 照子, 本橋 ほづみ

日本生化学会大会プログラム・講演要旨集　86回　3P-182　2013/09

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy Peer-reviewed

Yoshinobu Ichimura, Satoshi Waguri, Yu-shin Sou, Shun Kageyama, Jun Hasegawa, Ryosuke Ishimura, Tetsuya Saito, Yinjie Yang, Tsuguka Kouno, Toshiaki Fukutomi, Takayuki Hoshii, Atsushi Hirao, Kenji Takagi, Tsunehiro Mizushima, Hozumi Motohashi, Myung-Shik Lee, Tamotsu Yoshimori, Keiji Tanaka, Masayuki Yamamoto, Masaaki Komatsu

MOLECULAR CELL　51　(5)　618-631　2013/09

DOI： 10.1016/j.molcel.2013.08.003 　

ISSN： 1097-2765

eISSN： 1097-4164

Transforming Growth Factor-beta Induces Transcription Factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene Peer-reviewed

Yukari Okita, Atsushi Kamoshida, Hiroyuki Suzuki, Ken Itoh, Hozumi Motohashi, Kazuhiko Igarashi, Masayuki Yamamoto, Tomohiro Ogami, Daizo Koinuma, Mitsuyasu Kato

JOURNAL OF BIOLOGICAL CHEMISTRY　288　(28)　20658-20667　2013/07

DOI： 10.1074/jbc.M113.450478 　

ISSN： 0021-9258

Nf-e2 p45 is important for establishing normal function of platelets Peer-reviewed

Rie Fujita, Mariko Takayama-Tsujimoto, Hironori Satoh, Masayuki Yamamoto, Laura Gutiérrez, Hiroyuki Aburatani, Satoshi Fujii, Akinori Sarai, Bresnick Emery, Hozumi Motohashi

Molecular and Cellular Biology　33　(14)　2659-2670　2013/07

DOI： 10.1128/MCB.01274-12 　

ISSN： 0270-7306 1098-5549

eISSN： 1098-5549

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels Peer-reviewed

Takafumi Suzuki, Tatsuhiro Shibata, Kai Takaya, Kouya Shiraishi, Takashi Kohno, Hideo Kunitoh, Koji Tsuta, Koh Furuta, Koichi Goto, Fumie Hosoda, Hiromi Sakamoto, Hozumi Motohashi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　33　(12)　2402-2412　2013/06

DOI： 10.1128/MCB.00065-13 　

ISSN： 0270-7306

Disruption of the Hbs1L-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model Peer-reviewed

Mikiko Suzuki, Hiromi Yamazaki, Harumi Y. Mukai, Hozumi Motohashi, Lihong Shi, Osamu Tanabe, James Douglas Engel, Masayuki Yamamoto

Molecular and Cellular Biology　33　(8)　1687-1695　2013/04

DOI： 10.1128/MCB.01617-12 　

ISSN： 0270-7306 1098-5549

がん細胞におけるKeap1-Nrf2制御系の機能と役割 Invited Peer-reviewed

村上昌平, 本橋ほづみ

医学のあゆみ　247　(9)　811-818　2013

ISSN： 0039-2359

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration Peer-reviewed

Motohiro Nishida, Tomohiro Sawa, Naoyuki Kitajima, Katsuhiko Ono, Hirofumi Inoue, Hideshi Ihara, Hozumi Motohashi, Masayuki Yamamoto, Makoto Suematsu, Hitoshi Kurose, Albert van der Vliet, Bruce A. Freeman, Takahiro Shibata, Koji Uchida, Yoshito Kumagai, Takaaki Akaike

NATURE CHEMICAL BIOLOGY　8　(8)　714-724　2012/08

DOI： 10.1038/NCHEMBIO.1018 　

ISSN： 1552-4450

eISSN： 1552-4469

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Peer-reviewed

Kai Takaya, Takafumi Suzuki, Hozumi Motohashi, Ko Onodera, Susumu Satomi, Thomas W. Kensler, Masayuki Yamamoto

FREE RADICAL BIOLOGY AND MEDICINE　53　(4)　817-827　2012/08

DOI： 10.1016/j.freeradbiomed.2012.06.023 　

ISSN： 0891-5849

Keap1 degradation by autophagy for the maintenance of redox homeostasis Peer-reviewed

Keiko Taguchi, Nanako Fujikawa, Masaaki Komatsu, Tetsuro Ishii, Michiaki Unno, Takaaki Akaike, Hozumi Motohashi, Masayuki Yamamoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　109　(34)　13561-13566　2012/08

DOI： 10.1073/pnas.1121572109 　

ISSN： 0027-8424

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming Peer-reviewed

Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi

CANCER CELL　22　(1)　66-79　2012/07

DOI： 10.1016/j.ccr.2012.05.016 　

ISSN： 1535-6108

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma Peer-reviewed

Daisuke Inoue, Takashi Suzuki, Yoichiro Mitsuishi, Yasuhiro Miki, Satoshi Suzuki, Shunichi Sugawara, Mika Watanabe, Akira Sakurada, Chiaki Endo, Akira Uruno, Hironobu Sasano, Takayuki Nakagawa, Kennichi Satoh, Nobuyuki Tanaka, Hiroshi Kubo, Hozumi Motohashi, Masayuki Yamamoto

CANCER SCIENCE　103　(4)　760-766　2012/04

DOI： 10.1111/j.1349-7006.2012.02216.x 　

ISSN： 1347-9032

eISSN： 1349-7006

Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins Peer-reviewed

Hiromi Yamazaki, Fumiki Katsuoka, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　32　(4)　808-816　2012/02

DOI： 10.1128/MCB.06543-11 　

ISSN： 0270-7306

Molecular basis of Keap1-Nrf2 system function

YAMAMOTO Masayuki, TAGUCHI Keiko, SUZUKI Takafumi, MOTOHASHI Hozumi

Annual Meeting of the Japanese Society of Toxicology　39　SL3　2012

DOI： 10.14869/toxpt.39.2.0.SL3.0 　

Keap1-Nrf2 system for maintenance of redox homeostasis

TAGUCHI Keiko, FUJIKAWA Nanako, MOTOHASHI Hozumi, YAMAMOTO Masayuki

Annual Meeting of the Japanese Society of Toxicology　39　AS3-4　2012

DOI： 10.14869/toxpt.39.2.0.AS3-4.0 　

Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer Peer-reviewed

Masanobu Morita, Hozumi Motohashi

Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling　63-82　2011/11/07

DOI： 10.1002/9781118148143.ch5 　

Inducible disruption of autophagy in the lung causes airway hyper-responsiveness Peer-reviewed

Daisuke Inoue, Hiroshi Kubo, Keiko Taguchi, Takashi Suzuki, Masaaki Komatsu, Hozumi Motohashi, Masayuki Yamamoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　405　(1)　13-18　2011/02

DOI： 10.1016/j.bbrc.2010.12.092 　

ISSN： 0006-291X

Molecular Determinants for Small Maf Protein Control of Platelet Production Peer-reviewed

Hozumi Motohashi, Rie Fujita, Mariko Takayama, Ai Inoue, Fumiki Katsuoka, Emery H. Bresnick, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　31　(1)　151-162　2011/01

DOI： 10.1128/MCB.00798-10 　

ISSN： 0270-7306

The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response Peer-reviewed

Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Kit I. Tong, Tomoaki Ida, Tatsuya Okamoto, Ahmed Khandaker Ahtesham, Yu Ishima, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike

JOURNAL OF BIOLOGICAL CHEMISTRY　285　(31)　23970-23984　2010/07

DOI： 10.1074/jbc.M110.145441 　

ISSN： 0021-9258

eISSN： 1083-351X

Role of Keap1 S-guanylation in the antioxidant adaptive response in C6 glioma cells Peer-reviewed

Fujii Shigemoto, Sawa Tomohiro, Ihara Hideshi, Ida Tomoaki, Okamoto Tatsuya, Motohashi Hozumi, Yamamoto Masayuki, Akaike Takaaki

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　22　S58-S58　2010/06

DOI： 10.1016/j.niox.2010.05.168 　

ISSN： 1089-8603

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1 Peer-reviewed

Keiko Taguchi, Jonathan M. Maher, Takafumi Suzuki, Yukie Kawatani, Hozumi Motohashi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　30　(12)　3016-3026　2010/06

DOI： 10.1128/MCB.01591-09 　

ISSN： 0270-7306

eISSN： 1098-5549

Genetic Analysis of Hierarchical Regulation for Gata1 and NF-E2 p45 Gene Expression in Megakaryopoiesis Peer-reviewed

Mariko Takayama, Rie Fujita, Mikiko Suzuki, Ryuhei Okuyama, Setsuya Aiba, Hozumi Motohashi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　30　(11)　2668-2680　2010/06

DOI： 10.1128/MCB.01304-09 　

ISSN： 0270-7306

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Peer-reviewed

Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, Keiko Taguchi, Akira Kobayashi, Yoshinobu Ichimura, Yu-Shin Sou, Izumi Ueno, Ayako Sakamoto, Kit I. Tong, Mihee Kim, Yasumasa Nishito, Shun-ichiro Iemura, Tohru Natsume, Takashi Ueno, Eiki Kominami, Hozumi Motohashi, Keiji Tanaka, Masayuki Yamamoto

NATURE CELL BIOLOGY　12　(3)　213-U17　2010/03

DOI： 10.1038/ncb2021 　

ISSN： 1465-7392

eISSN： 1476-4679

NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation Peer-reviewed

Hozumi Motohashi, Momoko Kimura, Rie Fujita, Ai Inoue, Xiaoqing Pan, Mariko Takayama, Fumiki Katsuoka, Hiroyuki Aburatani, Emery H. Bresnick, Masayuki Yamamoto

BLOOD　115　(3)　677-686　2010/01

DOI： 10.1182/blood-2009-05-223107 　

ISSN： 0006-4971

Structural Basis of Alternative DNA Recognition by Maf Transcription Factors Peer-reviewed

Hirofumi Kurokawa, Hozumi Motohashi, Shinji Sueno, Momoko Kimura, Hiroaki Takagawa, Yousuke Kanno, Masayuki Yamamoto, Toshiyuki Tanaka

MOLECULAR AND CELLULAR BIOLOGY　29　(23)　6232-6244　2009/12

DOI： 10.1128/MCB.00708-09 　

ISSN： 0270-7306

eISSN： 1098-5549

Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production Peer-reviewed

Keiko Nohara, Takehiro Suzuki, Kana Ao, Hikari Murai, Yoshimi Miyamoto, Kaoru Inouye, Xiaoqing Pan, Hozumi Motohashi, Yoshiaki Fujii-Kuriyama, Masayuki Yamamoto, Chiharu Tohyama

INTERNATIONAL IMMUNOLOGY　21　(7)　769-777　2009/07

DOI： 10.1093/intimm/dxp045 　

ISSN： 0953-8178

Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity Peer-reviewed

Tae Yamamoto, Takafumi Suzuki, Akira Kobayashi, Junko Wakabayashi, Jon Maher, Hozumi Motohashi, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　28　(8)　2758-2770　2008/04

DOI： 10.1128/MCB.01704-07 　

ISSN： 0270-7306

eISSN： 1098-5549

Physiological role of Keap1 S-guanylation by 8-nitroguanosine 3',5'-cyclic monophosphate formed in C6 glioma cells Peer-reviewed

Shigemoto Fujii, Tomohiro Sawa, Tatsuya Okamoto, Hideshi Ihara, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　19　S35-S36　2008

DOI： 10.1016/j.niox.2008.06.069 　

ISSN： 1089-8603

Nitric oxide-dependent sulfhydryl modification of Keap1 by 8-nitroguanosine 3 ',5 '-cyclic monophosphate Peer-reviewed

Tomohiro Sawa, Shigemoto Fujii, Atsushi Irie, Tatsuya Okamoto, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike

NITRIC OXIDE-BIOLOGY AND CHEMISTRY　19　S61-S61　2008

DOI： 10.1016/j.niox.2008.06.176 　

ISSN： 1089-8603

Inducibility of cytochrome P450 1A1 and chemical carcinogenesis by benzo[a]pyrene in AhR repressor-deficient mice Peer-reviewed

Tomonori Hosoya, Nobuhiko Harada, Junsei Mimura, Hozumi Motohashi, Satoru Takahashi, Osamu Nakajima, Masanobu Morita, Shimako Kawauchi, Masayuki Yamamoto, Yoshiaki Fujii-Kuriyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　365　(3)　562-567　2008/01

DOI： 10.1016/j.bbrc.2007.11.016 　

ISSN： 0006-291X

Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2 Peer-reviewed

Takafumi Suzuki, Vincent P. Kelly, Hozumi Motohashi, Osamu Nakajima, Satoru Takahashi, Susumu Nishimura, Masayuki Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY　283　(4)　2021-2030　2008/01

DOI： 10.1074/jbc.M708352200 　

ISSN： 0021-9258

c-Myb regulates CD9 gene expression during megakaryopoiesis. Peer-reviewed

Harumi Y. Mukai, Tomoko Kono, Hozumi Motohashi, Masayuki Yamamoto, Hiroshima Kojima

BLOOD　110　(11)　376A-376A　2007/11

ISSN： 0006-4971

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of maf homodimer Peer-reviewed

Momoko Kimura, Tae Yamamoto, Jianyong Zhang, Ken Itoh, Motoki Kyo, Terue Kamiya, Hiroyuki Aburatani, Fumiki Katsuoka, Hirofumi Kurokawa, Toshiyuki Tanaka, Hozumi Motohashi, Masayuki Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY　282　(46)　in press　2007/11

DOI： 10.1074/jbc.M706863200 　

ISSN： 0021-9258

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes Peer-reviewed

Jianyong Zhang, Tomonori Hosoya, Atsushi Maruyama, Keizo Nishikawa, Jonathan M. Maher, Tsutomu Ohta, Hozumi Motohashi, Akiyoshi Fukamizu, Shigeki Shibahara, Ken Itoh, Masayuki Yamamoto

BIOCHEMICAL JOURNAL　404　(3)　459-466　2007/06

DOI： 10.1042/BJ20061611 　

ISSN： 0264-6021

CLARA-CELL SPECIFIC KEAP1 CONDITIONAL KNOCKOUT MICE HAVE STRONG NRF2 ACTIVATION BUT ARE SENSITIVE TO BLEOMYCIN-INDUCED LUNG INJURY

Maher, Jonathan M, Suzuki, Takafumi, Teguchi, Keiko, Kawatani, Yukie, Kimura, Momoko, Motohashi, Hozumi, Ishii, Yukio, Yamamoto, Masayuki

DRUG METABOLISM REVIEWS　39　(Suppl. 1)　537-0　2007/01

ISSN： 0360-2532

Transgene insertion into the proximity of the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Peer-reviewed

Harumi Yamamoto Mukai, Hozumi Motohashi, Toshiro Nagasawa, Masayuki Yamamoto

BLOOD　108　(11)　346A-346A　2006/11

ISSN： 0006-4971

Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation Peer-reviewed

Harumi Y. Mukai, Hozumi Motohashi, Osamu Ohneda, Norio Suzuki, Masumi Nagano, Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　26　(21)　7953-7965　2006/11

DOI： 10.1128/MCB.00718-06 　

ISSN： 0270-7306

MafG sumoylation is required for active transcriptional repression. International-journal Peer-reviewed

Hozumi Motohashi, Fumiki Katsuoka, Chika Miyoshi, Yasuhiro Uchimura, Hisato Saitoh, Claire Francastel, James Douglas Engel, Masayuki Yamamoto

Molecular and cellular biology　26　(12)　4652-63　2006/06

DOI： 10.1128/MCB.02193-05 　

ISSN： 0270-7306

Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements Peer-reviewed

T Yamamoto, M Kyo, T Kamiya, T Tanaka, JD Engel, H Motohashi, M Yamamoto

GENES TO CELLS　11　(6)　575-591　2006/06

DOI： 10.1111/j.1365-2443.2006.00965.x 　

ISSN： 1356-9597

Players regulating and supporting cytoprotective function of Nrf2 Peer-reviewed

Hozumi Motohashi, Takafumi Suzuki, Hiromi Okawa, Kit Tong, Fumiki Katsuoka, Akira Kobayashi, Masayuki Yamamoto

DRUG METABOLISM REVIEWS　38　22-22　2006

ISSN： 0360-2532

Functional analysis of Keap1 in vivo as a electrophile-responsive regulator of Nrf2 Peer-reviewed

Takafumi Suzuki, Tae Yamamoto, Akira Kobayashi, Hozumi Motohashi, Masayuki Yamamoto, Masayuki Yamamoto

DRUG METABOLISM REVIEWS　38　123-124　2006

ISSN： 0360-2532

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity Peer-reviewed

H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, M Yamamoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　339　(1)　79-88　2006/01

DOI： 10.1016/j.bbrc.2005.10.185 　

ISSN： 0006-291X

eISSN： 1090-2104

Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions Peer-reviewed

M Tauchi, A Hida, T Negishi, F Katsuoka, S Noda, J Mimura, T Hosoya, A Yanaka, H Aburatani, Y Fujii-Kuriyama, H Motohashi, M Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　25　(21)　9360-9368　2005/11

DOI： 10.1128/MCB.25.21.9360-9368.2005 　

ISSN： 0270-7306

転写因子c-Mybによる巨核球系造血制御機構の解明 Peer-reviewed

向井 陽美, 本橋 ほづみ, 鈴木 教郎, 長澤 俊郎, 山本 雅之

日本血液学会・日本臨床血液学会総会プログラム・抄録集　67回・47回　745-745　2005/09

Genetic evidence that small Maf proteins are essential for the activation of antioxidant response element-dependent genes Peer-reviewed

F Katsuoka, H Motohashi, T Ishii, H Aburatani, JD Engel, M Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　25　(18)　8044-8051　2005/09

DOI： 10.1128/MCB.25.18.8044-8051.2005 　

ISSN： 0270-7306

Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes Peer-reviewed

K Nohara, XQ Pan, S Tsukumo, A Hida, T Ito, H Nagai, K Inouye, H Motohashi, M Yamamoto, Y Fujii-Kuriyama, C Tohyama

JOURNAL OF IMMUNOLOGY　174　(5)　2770-2777　2005/03

ISSN： 0022-1767

Nrf2 transcriptionally activates the mafG gene through an antioxidant response element Peer-reviewed

F Katsuoka, H Motohashi, JD Engel, M Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY　280　(6)　4483-4490　2005/02

DOI： 10.1074/jbc.M411451200 　

ISSN： 0021-9258

Identification of polymorphisms in the promoter region of the human NRF2 gene Peer-reviewed

T Yamamoto, K Yoh, A Kobayashi, Y Ishii, S Kure, A Koyama, T Sakamoto, K Sekizawa, H Motohashi, M Yamamoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　321　(1)　72-79　2004/08

DOI： 10.1016/j.bbrc.2004.06.112 　

ISSN： 0006-291X

A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest Peer-reviewed

T Ito, S Tsukumo, N Suzuki, H Motohashi, M Yamamoto, Y Fujii-Kuriyama, J Mimura, TM Lin, RE Peterson, C Tohyama, K Nohara

JOURNAL OF BIOLOGICAL CHEMISTRY　279　(24)　25204-25210　2004/06

DOI： 10.1074/jbc.M402143200 　

ISSN： 0021-9258

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Peer-reviewed

H Motohashi, F Katsuoka, JD Engel, M Yamamoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　101　(17)　6379-6384　2004/04

DOI： 10.1073/pnas.0305902101 　

ISSN： 0027-8424

Evaluation of MafG interaction with Maf recognition element arrays by surface plasmon resonance imaging technique Peer-reviewed

M Kyo, T Yamamoto, H Motohashi, T Kamiya, T Kuroita, T Tanaka, JD Engel, B Kawakami, M Yamamoto

GENES TO CELLS　9　(2)　153-164　2004/02

DOI： 10.1111/j.1365-2443.2004.00711.x 　

ISSN： 1356-9597

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation Peer-reviewed

N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi, S Noda, S Takahashi, S Imakado, T Kotsuji, F Otsuka, DR Roop, T Harada, JD Engel, M Yamamoto

NATURE GENETICS　35　(3)　238-245　2003/11

DOI： 10.1038/ng1248 　

ISSN： 1061-4036

eISSN： 1546-1718

Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels Peer-reviewed

N Suzuki, N Suwabe, O Ohneda, N Obara, S Imagawa, XQ Pan, H Motohashi, M Yamamoto

BLOOD　102　(10)　3575-3583　2003/11

DOI： 10.1182/blood-2003-04-1154 　

ISSN： 0006-4971

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse Peer-reviewed

T Moriguchi, H Motohashi, T Hosoya, O Nakajima, S Takahashi, S Ohsako, Y Aoki, N Nishimura, C Tohyama, Y Fujii-Kuriyama, M Yamamoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　100　(10)　5652-5657　2003/05

DOI： 10.1073/pnas.1037886100 　

ISSN： 0027-8424

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway - Identification of novel gene clusters for cell survival Peer-reviewed

MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, TW Kensler

JOURNAL OF BIOLOGICAL CHEMISTRY　278　(10)　8135-8145　2003/03

DOI： 10.1074/jbc.M211898200 　

ISSN： 0021-9258

Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse Peer-reviewed

S Noda, N Harada, A Hida, Y Fujii-Kuriyama, H Motohashi, M Yamamoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　303　(1)　105-111　2003/03

DOI： 10.1016/S0006-291X(03)00306-1 　

ISSN： 0006-291X

Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response Peer-reviewed

F Katsuoka, H Motohashi, Y Tamagawa, S Kure, K Igarashi, JD Engel, M Yamamoto

MOLECULAR AND CELLULAR BIOLOGY　23　(4)　1163-1174　2003/02

DOI： 10.1128/MCB.23.4.1163-1174.2003 　

ISSN： 0270-7306

eISSN： 1098-5549

Solution structure of the DNA-binding domain of MafG Peer-reviewed

H Kusunoki, H Motohashi, F Katsuoka, A Morohashi, M Yamamoto, T Tanaka

NATURE STRUCTURAL BIOLOGY　9　(4)　252-256　2002/04

DOI： 10.1038/nsb771 　

ISSN： 1072-8368

Transgenic over-expression proliferation and function of MafK suppresses T cell in vivo Peer-reviewed

K Yoh, T Sugawara, H Motohashi, Y Takahama, A Koyama, M Yamamoto, S Takahashi

GENES TO CELLS　6　(12)　1055-1066　2001/12

DOI： 10.1046/j.1365-2443.2001.00489.x 　

ISSN： 1356-9597

Effect of acoustic overstimulation on regulation of glucocorticoid receptor mRNA in the cochlea of the guinea pig Peer-reviewed

T Terunuma, A Hara, M Senarita, H Motohashi, J Kusakari

HEARING RESEARCH　151　(1-2)　121-124　2001/01

DOI： 10.1016/S0378-5955(00)00218-5 　

ISSN： 0378-5955

Positive or negative MARE-dependent transcriptional regulation is by the abundance of small Maf proteins Peer-reviewed

H Motohashi, F Katsuoka, JA Shavit, JD Engel, M Yamamoto

CELL　103　(6)　865-875　2000/12

DOI： 10.1016/S0092-8674(00)00190-2 　

ISSN： 0092-8674

eISSN： 1097-4172

One enhancer mediates mafK transcriptional activation in both hematopoietic and cardiac muscle cells Peer-reviewed

F Katsuoka, H Motohashi, K Onodera, N Suwabe, JD Engel, M Yamamoto

EMBO JOURNAL　19　(12)　2980-2991　2000/06

DOI： 10.1093/emboj/19.12.2980 　

ISSN： 0261-4189

eISSN： 1460-2075

Oxidative stress abolishes Crm1/Exportin1-dependent nuclear export of Maf-interacting transcription repressor Bach2. Peer-reviewed

J. Biol. Chem.　275　15370-15376　2000/05

DOI： 10.1074/jbc.275.20.15370 　

Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element Peer-reviewed

H Hoshino, A Kobayashi, M Yoshida, N Kudo, T Oyake, H Motohashi, N Hayashi, M Yamamoto, K Igarashi

JOURNAL OF BIOLOGICAL CHEMISTRY　275　(20)　15370-15376　2000/05

DOI： 10.1074/jbc.275.20.15370 　

ISSN： 0021-9258

Perinatal synthetic lethality and hematopoietic defects in compound mafG : mafK mutant mice Peer-reviewed

K Onodera, JA Shavit, H Motohashi, M Yamamoto, JD Engel

EMBO JOURNAL　19　(6)　1335-1345　2000/03

DOI： 10.1093/emboj/19.6.1335 　

ISSN： 0261-4189

Characterization of the murine mafF gene Peer-reviewed

K Onodera, JA Shavit, H Motohashi, F Katsuoka, JE Akasaka, JD Engel, M Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY　274　(30)　21162-21169　1999/07

DOI： 10.1074/jbc.274.30.21162 　

ISSN： 0021-9258

A core region of the mafK gene I-N promoter directs neurone-specific transcription in vivo Peer-reviewed

H Motohashi, U Ohta, LD Engel, M Yamamoto

GENES TO CELLS　3　(10)　671-684　1998/10

DOI： 10.1046/j.1365-2443.1998.00222.x 　

ISSN： 1356-9597

Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice Peer-reviewed

JA Shavit, H Motohashi, K Onodera, J Akasaka, M Yamamoto, JD Engel

GENES & DEVELOPMENT　12　(14)　2164-2174　1998/07

ISSN： 0890-9369

Arrest in primitive erythroid cell development caused by promoter-specific disruption of the GATA-1 gene Peer-reviewed

S Takahashi, K Onodera, H Motohashi, N Suwabe, N Hayashi, N Yanai, Y Nabesima, M Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY　272　(19)　12611-12615　1997/05

DOI： 10.1074/jbc.272.19.12611 　

ISSN： 0021-9258

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis Peer-reviewed

K Onodera, S Takahashi, S Nishimura, J Ohta, H Motohashi, K Yomogida, N Hayashi, JD Engel, M Yamamoto

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　94　(9)　4487-4492　1997/04

DOI： 10.1073/pnas.94.9.4487 　

ISSN： 0027-8424

Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy Peer-reviewed

H Ohtani, H Motohashi, H Sato, M Seiki, H Nagura

INTERNATIONAL JOURNAL OF CANCER　68　(5)　565-570　1996/11

DOI： 10.1002/(SICI)1097-0215(19961127)68:5<565::AID-IJC2>3.0.CO;2-X 　

ISSN： 0020-7136

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site Peer-reviewed

T Oyake, K Itoh, H Motohashi, N Hayashi, H Hoshino, M Nishizawa, M Yamamoto, K Igarashi

MOLECULAR AND CELLULAR BIOLOGY　16　(11)　6083-6095　1996/11

ISSN： 0270-7306

Mesodermal- vs neuronal-specific expression of MafK is elicited by different promoters Peer-reviewed

H Motohashi, K Igarashi, K Onodera, S Takahashi, H Ohtani, M Nakafuku, M Nishizawa, JD Engel, M Yamamoto

GENES TO CELLS　1　(2)　223-238　1996/02

ISSN： 1356-9597

ACTIVITY AND EXPRESSION OF MURINE SMALL MAF FAMILY PROTEIN MAFK Peer-reviewed

K IGARASHI, K ITOH, H MOTOHASHI, N HAYASHI, Y MATUZAKI, H NAKAUCHI, M NISHIZAWA, M YAMAMOTO

JOURNAL OF BIOLOGICAL CHEMISTRY　270　(13)　7615-7624　1995/03

DOI： 10.1074/jbc.270.13.7615 　

ISSN： 0021-9258

eISSN： 1083-351X

LOSS OF DNA-BINDING ABILITY OF THE TRANSCRIPTION FACTOR ENCODED BY THE MUTANT MI-LOCUS Peer-reviewed

E MORII, K TAKEBAYASHI, H MOTOHASHI, M YAMAMOTO, S NOMURA, Y KITAMURA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　205　(2)　1299-1304　1994/12

DOI： 10.1006/bbrc.1994.2806 　

ISSN： 0006-291X

DYSGENESIS OF MELANOCYTES AND COCHLEAR DYSFUNCTION IN MUTANT MICROPHTHALMIA (MI) MICE Peer-reviewed

H MOTOHASHI, K HOZAWA, T OSHIMA, T TAKEUCHI, T TAKASAKA

HEARING RESEARCH　80　(1)　10-20　1994/10

DOI： 10.1016/0378-5955(94)90003-5 　

ISSN： 0378-5955

TRANSCRIPTION FACTOR GATA-2 IS EXPRESSED IN ERYTHROID, EARLY MYELOID, AND CD34+ HUMAN LEUKEMIA-DERIVED CELL-LINES Peer-reviewed

T NAGAI, H HARIGAE, H ISHIHARA, H MOTOHASHI, N MINEGISHI, S TSUCHIYA, N HAYASHI, L GU, B ANDRES, JD ENGEL, M YAMAMOTO

BLOOD　84　(4)　1074-1084　1994/08

ISSN： 0006-4971

HUMAN GATA-3 TRANSACTIVATION, DNA-BINDING, AND NUCLEAR-LOCALIZATION ACTIVITIES ARE ORGANIZED INTO DISTINCT STRUCTURAL DOMAINS Peer-reviewed

ZY YANG, PH ROMEO, D BORIES, H MOTOHASHI, M YAMAMOTO, JD ENGEL, L GU

MOLECULAR AND CELLULAR BIOLOGY　14　(3)　2201-2212　1994/03

ISSN： 0270-7306

A report of two cases of cervical necrotizing soft-tissue infection

Motohashi, H., Baba, S., Tada, M., Takahashi, K., Sakurai, T.

Nippon Jibiinkoka Gakkai Kaiho　95　(9)　1992

DOI： 10.3950/jibiinkoka.95.1332 　

ISSN： 0030-6622