Details of the Researcher

PHOTO

Akiko Kikuchi
Section
Graduate School of Medicine
Job title
Senior Assistant Professor
Degree

Research Areas 1

  • Life sciences / Internal medicine - General / traditional Japanese (kampo) medicine

Papers 118

  1. A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci. International-journal

    Junko Kohno, Tsuyoshi Kawamura, Akiko Kikuchi, Tetsuya Akaishi, Shin Takayama, Tadashi Ishii

    Scientific reports　11　(1)　11300-11300　2021/05/28

    DOI： 10.1038/s41598-021-90890-4 　

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    Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on their characteristics and treatment with Kampo medicines. This retrospective observational study collected data from VRE-positive patients from August 2018 to July 2019 at a tertiary-care hospital in Japan. The data of 122 consecutive VRE-positive inpatients were analyzed. Sixty-nine patients were treated with probiotics, among whom, 18 were further treated with Kampo medicines. Twenty-six of the 122 patients subsequently died. In univariate analyses, subsequent VRE negative conversion significantly reduced the mortality of VRE-detected patients (p = .0003). Administration of probiotics (p = .0065) and Kampo medicines with probiotics (p = .0002), especially of the Kampo medicine hochuekkito (p = .0014), and a higher serum albumin level positively contributed to the subsequent VRE negative conversion. Multivariate analyses demonstrated that Kampo medicines and body mass index contributed to VRE negative conversion. Hochuekkito shortened the time needed for VRE negative conversion (p = 0.0485). Administration of Kampo medicines, especially of hochuekkito, in addition to probiotics in VRE patients may promote VRE negative conversion.

  2. Kakkonto Inhibits Cytokine Production Induced by Rhinovirus Infection in Primary Cultures of Human Nasal Epithelial Cells. International-journal

    Natsumi Saito, Akiko Kikuchi, Mutsuo Yamaya, Xue Deng, Mitsuru Sugawara, Shin Takayama, Ryoichi Nagatomi, Tadashi Ishii

    Frontiers in pharmacology　12　687818-687818　2021

    DOI： 10.3389/fphar.2021.687818 　

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    Rhinovirus (RV) is a primary etiologic agent of common cold that can subsequently acutely exacerbate bronchial asthma or chronic obstructive pulmonary disease. Kakkonto (Ge-gen-tang in Chinese), one of the most frequently prescribed traditional Japanese (Kampo) medicines, is used for treating common cold, shoulder stiffness, or inflammatory diseases of the upper body. Previous experimental studies have indicated that kakkonto exerts antiviral and anti-inflammatory effects on the influenza virus and the human respiratory syncytial virus. However, there is a lack of reports investigating the efficacy of kakkonto in RV infection. Hence, the aim of the current study was to investigate the effects of kakkonto on RV infection of human nasal epithelial (HNE) cells. HNE cells obtained via endoscopic sinus surgery were cultured and infected with RV14, with or without kakkonto treatment. The supernatants from the cells were collected, and the RV14 titer and cytokine levels were assessed. Reverse transcription-polymerase chain reaction was performed to determine the amount of viral RNA, while the level of nuclear factor kappa B (NF-κB) subunits in the nucleus was assessed by enzyme-linked immunosorbent assay. Although kakkonto treatment did not reduce RV14 titer or RNA levels, indicating that it did not inhibit RV14 proliferation, it was found to reduce the production of specific pro-inflammatory cytokines, including interleukin (IL)-8, tumor necrosis factor (TNF)-α, and monocyte chemotactic protein-1 (MCP-1). Unlike that observed with the kakkonto extract, none of the crude drugs contained in kakkonto reduced IL-8 level. Furthermore, though kakkonto treatment significantly reduced p50 levels, it did not impact the p65 subunit of NF-κB. These results indicated that kakkonto can inhibit inflammation caused by RV infection and may exert an immunomodulatory effect on HNE cells. This is the first report to elucidate the effects of kakkonto extract on RV infection in primary cultures of HNE cells, providing evidence that kakkonto may act as an effective therapy for RV infection and subsequent airway inflammation.

  3. Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication. Peer-reviewed

    Mutsuo Yamaya, Hidekazu Nishimura, Xue Deng, Akiko Kikuchi, Ryoichi Nagatomi

    The Tohoku journal of experimental medicine　251　(1)　27-30　2020/05

    DOI： 10.1620/tjem.251.27 　

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    The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pretreated primary cultures of human nasal epithelial (HNE) cells with camostat or nafamostat, each of which has been used for the treatment of pancreatitis and/or disseminated intravascular coagulation. HNE cells were then infected with coronavirus 229E, and viral titers in the airway surface liquid of the cells were examined. Pretreatment with camostat (0.1-10 μg/mL) or nafamostat (0.01-1 μg/mL) reduced the titers of coronavirus 229E. Furthermore, a significant amount of type II transmembrane protease protein was detected in the airway surface liquid of HNE cells. Additionally, interferons have been reported to have antiviral effects against SARS coronavirus. The additive effects of interferons on the inhibitory effects of other candidate drugs to treat SARS-CoV-2 infection, such as lopinavir, ritonavir and favipiravir, have also been studied. These findings suggest that protease inhibitors of this type may inhibit coronavirus 229E replication in human airway epithelial cells at clinical concentrations. Protease inhibitors, interferons or the combination of these drugs may become candidate drugs to inhibit the replication of SARS-CoV-2.

  4. Characteristics and course of patients treated with Kampo Medicine in the Department of General Medicine. Peer-reviewed

    Shin Takayama, Tetsuya Akaishi, Hiroyuki Nozaki, Satoko Suzuki, Ryutaro Arita, Natsumi Saito, Junichi Tanaka, Takehiro Numata, Akiko Kikuchi, Minoru Ohsawa, Michiaki Abe, Tadashi Ishii

    Journal of general and family medicine　21　(3)　48-55　2020/05

    DOI： 10.1002/jgf2.294 　

    eISSN： 2189-7948

  5. Perspectives on the Use of Ninjin'yoeito in Modern Medicine: A Review of Randomized Controlled Trials. International-journal Peer-reviewed

    Shin Takayama, Ryutaro Arita, Minoru Ohsawa, Akiko Kikuchi, Hiromichi Yasui, Toshiaki Makino, Yoshiharu Motoo, Tadashi Ishii

    Evidence-based complementary and alternative medicine : eCAM　2019　9590260-9590260　2019

    DOI： 10.1155/2019/9590260 　

    ISSN： 1741-427X

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    Background: Ninjin'yoeito (NYT), a traditional Japanese (Kampo) medicine that originates from China, has been used to treat qi and blood deficiency based on its original concept. Kampo medicine has been widely used to treat many conditions and disorders combined with western medicine or Kampo medicine alone in modern situation. Aims: We reviewed randomized controlled trials (RCTs) of NYT and discussed various standpoints regarding its use in modern situation. Methods: We searched PubMed, Cochrane Library, and Evidence Reports of Kampo Treatment (EKAT) for articles written in English, and Ichushi, J-Stage, and EKAT for those written in Japanese. Articles published before January 1, 2019, were retrieved using the keywords "ninjinyoeito" and "ninjin'yoeito," and RCTs were selected from these extracted articles. Result: Of 734 articles, 13 were RCTs, 46 were non-RCTs or studies of other designs, 15 were case reports, and 36 were experimental studies using NYT. NYT was evaluated for its use as a treatment for cancer and related conditions, refractory blood diseases and conditions, and otorhinolaryngologic symptom in 13 RCTs. Based on the use of Kampo medicine in modern situation called as Yasui's classification, 10 of 13 RCTs were categorized as "the side effects of Western medicinal treatment are mitigated when combined with Kampo treatment" and the remaining 3 were categorized as "treatment effect of Kampo medicine is increased in combination with standard Western medicinal treatment." Conclusion. Several studies demonstrated the efficacy of NYT in refractory diseases and other conditions, and the accompanied side effects of treatment with western medicine.

  6. Traditional medicine as a potential treatment for Flammer syndrome. International-journal Peer-reviewed

    Akiko Kikuchi, Yukihiro Shiga, Shin Takayama, Ryutaro Arita, Shigeto Maekawa, Soichiro Kaneko, Noriko Himori, Tadashi Ishii, Toru Nakazawa

    The EPMA journal　8　(2)　171-175　2017/06

    DOI： 10.1007/s13167-017-0091-9 　

    ISSN： 1878-5077

  7. Literature Review: Herbal Medicine Treatment after Large-Scale Disasters Peer-reviewed

    Shin Takayama, Soichiro Kaneko, Takehiro Numata, Tetsuharu Kamiya, Ryutaro Arita, Natsumi Saito, Akiko Kikuchi, Minoru Ohsawa, Yoshitaka Kohayagawa, Tadashi Ishii

    AMERICAN JOURNAL OF CHINESE MEDICINE　45　(7)　1345-1364　2017

    DOI： 10.1142/S0192415X17500744 　

    ISSN： 0192-415X

    eISSN： 1793-6853

  8. EFFECT OF PRESS NEEDLES ON SWALLOWING REFLEX IN OLDER ADULTS WITH CEREBROVASCULAR DISEASE: A RANDOMIZED DOUBLE-BLIND CONTROLLED TRIAL Peer-reviewed

    Akiko Kikuchi, Takashi Seki, Shin Takayama, Koh Iwasaki, Satoshi Ishizuka, Nobuo Yaegashi

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　62　(12)　2438-2440　2014/12

    DOI： 10.1111/jgs.13164 　

    ISSN： 0002-8614

    eISSN： 1532-5415

  9. Heme oxygenase-1 gene promoter polymorphism and decline in lung function in Japanese men.

    Nakayama K, Kikuchi A, Yasuda H, Ebihara S, Sasaki T, Ebihara T, Yamaya M

    Thorax　61　(10)　921-921　2006

    DOI： 10.1136/thx.2006.066423 　

  10. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. International-journal Peer-reviewed

    Akiko Kikuchi, Mutsuo Yamaya, Satoshi Suzuki, Hiroyasu Yasuda, Hiroshi Kubo, Katsutoshi Nakayama, Masashi Handa, Takahiko Sasaki, Shigeki Shibahara, Kiyohisa Sekizawa, Hidetada Sasaki

    Human genetics　116　(5)　354-60　2005/04

    DOI： 10.1007/s00439-004-1162-2 　

    ISSN： 0340-6717

  11. Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells Peer-reviewed

    T Suzuki, M Yamaya, K Sekizawa, M Hosoda, N Yamada, S Ishizuka, A Yoshino, H Yasuda, H Takahashi, H Nishimura, H Sasaki

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　165　(8)　1113-1118　2002/04

    DOI： 10.1164/rccm.2103094 　

    ISSN： 1073-449X

  12. Daily oral care and risk factors for pneumonia among elderly nursing home patients Peer-reviewed

    A Yoshino, T Ebihara, S Ebihara, H Fuji, H Sasaki

    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　286　(18)　2235-2236　2001/11

    ISSN： 0098-7484

  13. Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition. International-journal

    Nana Takahashi, Yukihiro Shiga, Naoki Kiyota, Masayuki Yasuda, Naoki Takahashi, Kota Sato, Ryutaro Arita, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Toru Nakazawa

    Translational vision science & technology　14　(4)　9-9　2025/04/01

    DOI： 10.1167/tvst.14.4.9 　

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    PURPOSE: We tested the hypothesis that a questionnaire-based risk score predicts the prevalence of patients with primary open-angle glaucoma (POAG) with vascular predisposition. METHODS: The Flammer Syndrome Questionnaire (FSQ) was used to determine vascular risk scores in 823 healthy subjects and 512 patients with POAG. Next, we characterized blood flow pulsatility changes within the optic nerve head (ONH) in Flammer syndrome (FS) using laser speckle flowgraphy (LSFG) in 358 eyes of 206 patients with normal-tension glaucoma (NTG). Last, we examined the association between changes in Mean blur rate (MBRAve), an LSFG-derived ONH blood flow measurement, during cold provocation and the FSQ risk score in 56 eyes of 56 patients with NTG. RESULTS: Five FSQ-related symptoms were significantly associated in patients with POAG patients; cold hands/feet (odds ratio [OR] = 1.82), low blood pressure (BP; OR = 3.29), increased response to drugs (OR = 2.27), underweight (OR = 1.99), and tendency toward perfectionism (OR = 1.88). The vascular risk score showed the best discriminative accuracy in differentiating healthy subjects from patients with NTG (area under the curve [AUC] = 0.73). In the NTG eyes, ONH pulsatile blood flow in the FS group was characterized by greater pulsatility. Moreover, the negative correlation between the high FSQ risk score and the cold-induced ONH blood flow reduction was pronounced in eyes with NTG (correlation coefficient = -0.41). CONCLUSIONS: The FSQ risk score can be a screening tool to identify patients with POAG with increased vascular stiffness and further reduced ONH blood flow during cold stress. TRANSLATIONAL RELEVANCE: The vascular risk score may help tailor individual glaucoma care.

  14. Observer-Blind Randomized Crossover Trial of Yamamoto New Scalp Acupuncture in Diagnosis and Treatment Points for Neck Pain and Shoulder Stiffness in Healthy Participants

    Soichiro Kaneko, Tetsuharu Kamiya, Shin Takayama, Ryutaro Arita, Rie Ono, Akiko Kikuchi, Minoru Ohsawa, Takuya Suematsu, Fumiya Omata, Sachie Kasukabe, Manami Suzuki, Tadashi Ishii

    MEDICAL ACUPUNCTURE　2024/12/23

    DOI： 10.1089/acu.2024.0003 　

    ISSN： 1933-6586

    eISSN： 1933-6594

  15. The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

    Aoi Noda, Ryutaro Arita, Taku Obara, Satoko Suzuki, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Fumiko Matsuzaki, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Shinichi Kuriyama

    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　33　(10)　2024/10

    DOI： 10.1002/pds.70033 　

    ISSN： 1053-8569

    eISSN： 1099-1557

  16. Establishment of a Collaborative System for Long COVID Brain Fog Using a Questionnaire and Scoring

    Rie Ono, Shin Takayama, Taizen Nakase, Akiko Kikuchi, Ryutaro Arita, Michiaki Abe, Takeshi Kannno, Ko Onodera, Minoru Osawa, Kota Ishizawa, Natsumi Saito, Tadashi Ishii

    An Official Journal of the Japan Primary Care Association　47　(3)　120-123　2024/09/20

    Publisher: The Japan Primary Care Association

    DOI： 10.14442/generalist.47.120 　

    ISSN： 2185-2928

    eISSN： 2187-2791

  17. A Case Series of Post-COVID Conditions with Fatigability Treated with Saikokeishito

    Rie Ono, Shin Takayama, Natsumi Saito, Ryutaro Arita, Akiko Kikuchi, Kota Ishizawa, Takeshi Kanno, Akito Sugawara, Minoru Ohsawa, Michiaki Abe, Ko Onodera, Tetsuya Akaishi, Tadashi Ishii

    An Official Journal of the Japan Primary Care Association　47　(2)　49-55　2024/06/20

    Publisher: The Japan Primary Care Association

    DOI： 10.14442/generalist.47.49 　

    ISSN： 2185-2928

    eISSN： 2187-2791

  18. 漢方医学系統講義に対し医学生はどんな着眼点や印象持つのか?

    村上 慶泰, 有田 龍太郎, 金子 聡一郎, 石井 祐三, 齊藤 奈津美, 大澤 稔, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　75　(別冊)　331-331　2024/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  19. 漢方薬と鍼灸治療の併用により原因不明の筋肉のこわばりが改善した1症例

    石井 祐三, 金子 聡一郎, 齊藤 奈津美, 有田 龍太郎, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　75　(別冊)　358-358　2024/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  20. 漢方医学の卒前教育に活用できる気血津液体質チェックアンケートの開発と妥当性の検討

    有田 龍太郎, 神谷 哲治, 金子 聡一郎, 菊地 章子, 大澤 稔, 齊藤 奈津美, 村上 慶泰, 鈴木 聡子, 小野 理恵, 永田 真一, 高山 真, 石井 正

    日本東洋医学雑誌　75　(2)　152-167　2024/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  21. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. International-journal

    Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

    Drugs - real world outcomes　2024/01/19

    DOI： 10.1007/s40801-023-00411-0 　

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    BACKGROUND: Japanese traditional (Kampo) medicines containing ephedra may be used to treat colds during pregnancy. There are reports that ephedrine, a component of ephedra, has a risk of teratogenicity; however, the evidence remains equivocal. OBJECTIVE: This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with exposure to Kampo medicines containing ephedra during the first trimester of pregnancy using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: To 23,730 mother-infant pairs who participated in the TMM BirThree Cohort Study from July 2013 to March 2017, questionnaires in early and middle pregnancy were distributed approximately at weeks 12 and 26 of pregnancy, respectively. Infants' risk of MCMs in women who used Kampo medicines containing ephedra or acetaminophen during the first trimester was assessed, and the odds ratios (ORs) were estimated with unadjusted and adjusted analyses. RESULTS: Among 20,879 women, acetaminophen and Kampo medicines containing ephedra were used in 665 (3.19%) and 376 (1.80%) women, respectively, in the first trimester. Among the infants born to the mothers who used acetaminophen or Kampo medicine containing ephedra during the first trimester, 11 (1.65%) and 8 (2.13%), respectively, had overall MCMs. OR of overall MCMs was higher in women who used Kampo medicines containing ephedra than in those who used acetaminophen in the first trimester (adjusted OR, 1.45; 95% confidence interval (CIs), 0.57-3.71); however, the difference was not statistically significant. CONCLUSIONS: In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.

  22. Contribution of traditional Japanese Kampo medicines, kakkonto with shosaikotokakikyosekko, in treating patients with mild-to-moderate coronavirus disease 2019: Further analysis of a multicenter, randomized controlled trial. International-journal

    Shin Takayama, Takao Namiki, Ryutaro Arita, Rie Ono, Akiko Kikuchi, Minoru Ohsawa, Natsumi Saito, Satoko Suzuki, Hajime Nakae, Seiichi Kobayashi, Tetsuhiro Yoshino, Tomoaki Ishigami, Koichiro Tanaka, Airi Takagi, Takuhiro Yamaguchi, Tadashi Ishii, Akito Hisanaga, Kazuo Mitani, Takashi Ito

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　29　(11)　1054-1060　2023/11

    DOI： 10.1016/j.jiac.2023.07.013 　

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    We previously reported the finding of symptom relief in a randomized controlled trial with the combined use of kakkonto and shosaikotokakikyosekko added to conventional treatment in patients with coronavirus disease 2019 (COVID-19). For further evaluation, we performed post hoc analysis focused on symptom disappearance without recurrence, to determine a clearer effect of Kampo medicine. Patients with mild and moderate COVID-19 were randomly allocated to a control group receiving symptomatic therapy or a Kampo group receiving kakkonto (2.5 g) with shosaikotokakikyosekko (2.5 g) three times daily in addition to symptomatic therapy. The data of 161 patients (Kampo group, n = 81; control group, n = 80) were analyzed post hoc for the time to symptom disappearance. Kaplan-Meier and Cox proportional hazard estimates of disappearance of symptoms showed that all and each symptom targeted in this study disappeared faster in the Kampo group than in the control group, although not statistically significant (all symptomatic cases; hazard ratio [HR] 3.73, 95% confidence interval [CI] 0.46-29.98, log-rank p = 0.1763). In a supplemental assessment using covariate adjustment and competing risk analysis, fever disappeared faster in the Kampo group than in the control group (all symptomatic cases, HR 1.62, 95% CI 0.99-2.64, p = 0.0557; unvaccinated cases, HR 1.68, 95% CI 1.00-2.83, p = 0.0498) and shortness of breath disappeared significantly faster in Kampo group than in control group (all symptomatic cases, HR 1.92, 95% CI 1.07-3.42, p = 0.0278; unvaccinated cases, HR 2.15, 95% CI 1.17-3.96, p = 0.0141). These results demonstrate the advantages of Kampo treatment for acute COVID-19.

  23. COVID-19急性期症状、遷延症状への漢方薬治療に関する臨床研究の取り組みについて

    高山 真, 並木 隆雄, 三谷 和男, 久永 明人, 小田口 浩, 伊藤 隆, 有田 龍太郎, 小野 理恵, 齊藤 奈津美, 鈴木 聡子, 大澤 稔, 菊地 章子, 石井 正, 日本東洋医学会運営委員会特別ワーキンググループ

    和漢医薬学会学術大会要旨集　40回　37-37　2023/08

    Publisher: (一社)和漢医薬学会

  24. Progress and treatment of “long <scp>COVID</scp> ” in non‐hospitalized patients: A single‐center retrospective cohort study

    Rie Ono, Ryutaro Arita, Shin Takayama, Takeshi Kanno, Akiko Kikuchi, Satoko Suzuki, Minoru Ohsawa, Natsumi Saito, Michiaki Abe, Koh Onodera, Tetsuya Akaishi, Yasunori Tadano, Tadashi Ishii

    Traditional &amp; Kampo Medicine　10　(2)　150-158　2023/05/25

    Publisher: Wiley

    DOI： 10.1002/tkm2.1370 　

    ISSN： 2053-4515

    eISSN： 2053-4515

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    Abstract Background “Long COVID” or “post‐COVID conditions” describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID‐19). However, there is a paucity of published reports on its treatment. Method This retrospective cohort study included adult, non‐hospitalized patients with COVID‐19 symptoms at least one month after the onset who had been examined at the isolation facility in Miyagi prefecture between October 2020 and September 2021. Results In total, 70 patients with a median age of 46 (21–69) years were included, and 37 were women (52.9%). The median time from onset to the end of treatment was 46 (28–396) days. Thirty‐eight patients (53.5%) showed improvement in all symptoms, while four (5.7%) did not recover within the study period. The symptoms at six months with high residual rates were dizziness (33.3%), fatigue (14.3%), myalgia (14.3%), abdominal discomfort (14.3%), and taste dysfunction (11.8%). For treatment of prolonged symptoms, formulae of Kampo medicine (Japanese traditional medicine) were used alone or in combination with Western medications in 76%, 66%, 53%, and 66% of patients at 1–2 months, 2–3 months, 3–6 months, and over 6 months respectively. Kampo formulae with anti‐inflammatory effects were used in the early period; however, tonifying formulae and blood stasis‐resolving formulae were used in the late period. Conclusion Non‐hospitalized patients with COVID‐19 may suffer from persistent symptoms after the acute phase of infection. For the management of long COVID, a comprehensive and holistic approach is needed. Kampo medicine should be considered as a treatment option for long COVID.

  25. COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

    有田 龍太郎, 高山 真, 阿部 倫明, 菊地 章子, 大澤 稔, 小野寺 浩, 菅野 武, 齊藤 奈津美, 赤石 哲也, 小野 理恵, 只野 恭教, 鈴木 聡子, 菅原 章人, 石井 正

    日本プライマリ・ケア連合学会学術大会　14回　219-219　2023/05

    Publisher: (一社)日本プライマリ・ケア連合学会

  26. COVID-19学会主導研究により得られた経験と今後の展開 クリニカルリサーチコーディネーター(CRC)の実務から見出した多施設共同研究運営の課題と改善点

    桑原 安輝子, 高山 真, 有田 龍太郎, 小野 理恵, 齊藤 奈津美, 鈴木 聡子, 大澤 稔, 菊地 章子, 石井 正

    日本東洋医学雑誌　74　(別冊)　88-88　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  27. 転換期のがん診療へ漢方で切りこむ がんに対する中西医結合治療経験

    清水 雅行, 高山 真, 菊地 章子, 大澤 稔, 有田 龍太郎, 齊藤 奈津美, 鈴木 聡子, 小野 理恵, 石井 正

    日本東洋医学雑誌　74　(別冊)　101-101　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  28. クローン病の治療中、漢方エキス製剤よりも煎じ薬で寛解維持が可能となった1例

    有田 龍太郎, 菊地 章子, 小野 理恵, 高山 真, 金子 聡一郎, 神谷 哲治, 石井 正

    日本東洋医学雑誌　74　(別冊)　193-193　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  29. 開業鍼灸師と大学病院漢方内科鍼灸外来における連携について

    小泉 直照, 金子 聡一郎, 有田 龍太郎, 小野 理恵, 神谷 哲治, 村上 慶泰, 大澤 稔, 菊地 章子, 齊藤 奈津美, 清水 雅行, 鈴木 聡子, 永田 真一, 高山 真, 石井 正

    日本東洋医学雑誌　74　(別冊)　199-199　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  30. 化学物質過敏症(chemical sensitivity:CS)は中枢《脳》・末梢神経のみならず、消化器《腸》にも水滞を生じさせる

    大澤 稔, 高山 真, 菊地 章子, 有田 龍太郎, 金子 聡一郎, 神谷 哲治, 小野 理恵, 永田 真一, 清水 雅行, 齊藤 奈津美, 鈴木 聡子, 羽根田 健, 小泉 直照, 村上 慶泰, 石井 正

    日本東洋医学雑誌　74　(別冊)　210-210　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  31. 勤労世代に対する漢方治療がQOLに及ぼす影響

    小野 理恵, 菊地 章子, 有田 龍太郎, 高山 真, 大澤 稔, 齊藤 奈津美, 金子 聡一郎, 鈴木 聡子, 清水 雅行, 永田 真一, 神谷 哲治, 石井 正

    日本東洋医学雑誌　74　(別冊)　231-231　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  32. シスプラチン併用放射線療法による味覚障害に対して大学病院と地域病院鍼外来との連携により症状改善に貢献できた症例

    金子 聡一郎, 鈴木 聡子, 有田 龍太郎, 小野 理恵, 小泉 直照, 村上 慶泰, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　74　(別冊)　231-231　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  33. 大規模レセプトデータベースを用いた、妊婦への桃仁含有漢方薬と出生児の先天性奇形との関連についての研究

    鈴木 聡子, 高山 真, 菊地 章子, 有田 龍太郎, 大澤 稔, 石井 正, 小原 拓

    日本東洋医学雑誌　74　(別冊)　232-232　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  34. 新型コロナウイルス感染症の咽頭痛に対する桔梗湯と桔梗石膏の効果の比較

    菊地 章子, 小野 理恵, 有田 龍太郎, 齊藤 奈津美, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　74　(別冊)　233-233　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  35. COVID-19罹患後に遷延する微熱と倦怠感に対して柴胡清肝湯が効果を示した2症例

    齊藤 奈津美, 有田 龍太郎, 小野 理恵, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　74　(別冊)　236-236　2023/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  36. Press needle for aspiration pneumonia prevention in older adults: Study protocol for a randomized double-blind placebo-controlled trial. International-journal

    Soichiro Kaneko, Akiko Kikuchi, Shin Takayama, Ryutaro Arita, Minoru Ohsawa, Tetsuharu Kamiya, Tadashi Ishii

    Medicine　102　(7)　e32847　2023/02/17

    DOI： 10.1097/MD.0000000000032847 　

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    BACKGROUND: Pneumonia is the fifth most common cause of death among the Japanese population, with 97% of the deaths occurring among older adults aged ≥65 years. The incidence ratio of aspiration pneumonia is high among the older adults. Therefore, its prophylaxis is important in geriatric medicine. In our previous studies, we reported that stimulation of acupoints at stomach meridian 36 and kidney meridian 3 of the lower limbs with a press needle improved the swallowing function of patients with dysphagia. Improvements in swallowing function may prevent aspiration pneumonia. This study aims to investigate the protective efficacy of press needle stimulation in the lower limbs for aspiration pneumonia. METHODS/DESIGN: This is a multicenter, randomized, double-blind, placebo-controlled trial. A total of 140 patients with cerebrovascular disorder and a history of aspiration pneumonia will be recruited from 6 centers and randomly assigned to either the real or sham press needle group in a 1:1 ratio. The press needle will be replaced twice a week. The treatment will be administered bilaterally at acupoints stomach meridian 36 and kidney meridian 3. The primary outcome is the frequency of aspiration pneumonia onset. The secondary outcome is the improvement of the latent time of the swallowing reflex. The study period is of 12-month. The primary outcome will be evaluated throughout the study period, while the secondary outcomes will be assessed at baseline, 1st month, 6th month, and at the end of the investigation period. DISCUSSION: This study will evaluate the effects of press needle on the prevention of aspiration pneumonia and the improvement of swallowing function in patients. The results of this study will help support the prophylaxis of aspiration pneumonia.

  37. COVID-19の咳嗽に対する竹じょ温胆湯の使用経験

    小野 理恵, 高山 真, 有田 龍太郎, 菊地 章子, 大澤 稔, 齊藤 奈津美, 鈴木 聡子, 石井 正

    日本東洋医学雑誌　74　(1)　67-74　2023/01

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  38. 漢方Problem Based Learning(PBL)を基にした学術発表により得られる医学生の学び

    高山 真, 有田 龍太郎, 金子 聡一郎, 菊地 章子, 沼田 健裕, 石井 誠一, 谷内 一彦, 石井 正

    日本東洋医学雑誌　74　(1)　75-84　2023/01

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  39. Predictors for the Development of Hypoxia or Prolonged Acute Symptoms Among Non-Hospitalized Mild-To-Moderate Patients with Coronavirus Disease 2019

    Yasunori Tadano, Tetsuya Akaishi, Satoko Suzuki, Rie Ono, Natsumi Saito, Ryutaro Arita, Takeshi Kanno, Junichi Tanaka, Akiko Kikuchi, Minoru Ohsawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　260　(3)　231-244　2023

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2023.j038 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  40. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. International-journal

    Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Frontiers in pharmacology　14　1107494-1107494　2023

    DOI： 10.3389/fphar.2023.1107494 　

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    Traditional Japanese (Kampo) medicines containing rhubarb rhizome are prescribed for constipation during pregnancy; however, detailed safety information of their use for pregnant women is lacking. The aim of current study was to clarify the association between prescription Kampo-containing rhubarb rhizome (KRR) in the first trimester of pregnancy and congenital malformations in newborns. Using a large Japanese health insurance claims database, we included pregnant women who enrolled the same health insurance society from 3 months before pregnancy to the delivery date, who gave birth between 2010 and 2019, and those with data related to their infants. Pregnant women who were prescribed magnesium oxide (MgO), commonly used for constipation, during the first trimester of pregnancy and their infants were extracted as controls. Associations between KRR prescribed in the first pregnancy trimester and major congenital malformations (MCM) in the infants were examined using multivariate logistic regression analysis. Of 75,398 infants, 4,607 (6.1%) were diagnosed with MCMs within the first year after birth. Furthermore, 9,852 infants were born to women prescribed MgO, among whom 680 (6.9%) had MCMs; 450 infants were born to women prescribed KRR, among whom 28 (6.2%) had MCMs. Multivariate logistic regression analysis identified no difference in MCM risk between the two types of prescriptions [crude odds ratio (OR) 0.895, 95% confidence interval (CI) 0.606-1.322, adjusted OR 0.889, 95% CI 0.599-1.320]. In conclusion, the risk of MCMs did not differ between those prescribed KRR or MgO in the first trimester of pregnancy.

  41. 妊婦への大黄含有漢方薬の処方と出生児の先天奇形との関連に関する研究 大規模レセプトデータベースを用いて

    鈴木 聡子, 小原 拓, 石川 智史, 有田 龍太郎, 大澤 稔, 野田 あおい, 松崎 芙実子, 菊地 章子, 高山 真, 眞野 成康, 石井 正

    DOHaD研究　10　(2)　66-66　2022/10

    Publisher: (一社)日本DOHaD学会

    ISSN： 2187-2562

    eISSN： 2187-2597

  42. 新型コロナウイルス感染症軽症者等宿泊療養施設における管理課題解決のための情報共有・往診システムの構築

    高山 真, 有田 龍太郎, 小野 理恵, 只野 恭教, 菊地 章子, 稲葉 洋平, 中村 直毅, 阿部 倫明, 石井 正

    日本医療・病院管理学会誌　59　(4)　157-167　2022/10

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  43. COVID-19-Related Symptoms during the SARS-CoV-2 Omicron (B.1.1.529) Variant Surge in Japan.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　258　(2)　103-110　2022/08/25

    DOI： 10.1620/tjem.2022.J067 　

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    The exact profiles of the clinical symptoms related to the SARS-CoV-2 Omicron variant (B.1.1.529) remain largely uncertain. Therefore, this study aimed to clarify the clinical manifestations of infection with this variant. We enrolled individuals who were tested by quantitative nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) test at a large screening center in a city of Japan during the B.1.1.529 Omicron variant wave between January and May 2022, after contact with COVID-19 patients. Swab tests were planned to be performed approximately 4-5 days after contact. The presence of COVID-19-related symptoms was assessed at the swab test site. Among the 2,507 enrolled individuals, 943 (37.6%) were RT-PCR test-positive and 1,564 (62.4%) were test-negative. Among the 943 PCR test-positive participants, the prevalence of the symptoms was as follows: 47.3% with cough, 32.9% with sore throat, 18.4% with fatigability, 12.7% with fever of ≥ 37.5℃, 9.9% with dyspnea, 2.1% with dysosmia, and 1.4% with dysgeusia. The prevalence of cough, sore throat, dyspnea, and fatigability was higher among adults aged ≥ 18 years than among children and adolescents. The prevalence of dysosmia and dysgeusia remarkably decreased during the Omicron wave (1-3%) compared to during the pre-Omicron variant waves (15-25%). In summary, common COVID-19-related symptoms during the Omicron variant wave included cough and sore throat, followed by fatigability, fever, and dyspnea. The prevalence of most of these symptoms was higher in adults than in non-adults. The prevalence of dysosmia and dysgeusia remarkably decreased with the Omicron variant than with pre-Omicron variants.

  44. Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Hiroshi Egusa, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Minoru Ohsawa, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Scientific Reports　12　(1)　2022/08/10

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-022-17990-7 　

    eISSN： 2045-2322

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    Abstract The administration of a third booster dose of messenger ribonucleic acid (mRNA) vaccines against coronavirus disease 2019 (COVID-19) has progressed worldwide. Since January 2022, Japan has faced a nationwide outbreak caused by the Omicron variant, which occurred simultaneously with the progression of mass vaccination with the third booster dose. Therefore, this study evaluated the effectiveness of the third dose of vaccine by reverse transcription-polymerase chain reaction (RT-PCR) test using nasopharyngeal swab samples from adults aged ≥ 18 years tested after having close contact with COVID-19 cases between January and May 2022. Participants who completed only one dose were excluded from the study. Among the 928 enrolled participants, 139 had never been vaccinated, 609 had completed two doses, 180 had completed three doses before the swab test, and the overall RT-PCR test positivity rate in each group was 48.9%, 46.0%, and 32.2%, respectively. The vaccine effectiveness of the third dose to prevent infection after close contact was approximately 40% (95% confidence interval: 20–60%), which was the highest at 10–70 days after receiving the third dose. In conclusion, the effectiveness of the three-dose mRNA COVID-19 vaccine after close contact during the Omicron outbreak is approximately 40%.

  45. Fluorescence Sensing of the Panhandle Structure of the Influenza A Virus RNA Promoter by Thiazole Orange Base Surrogate-Carrying Peptide Nucleic Acid Conjugated with Small Molecule. International-journal

    Yusuke Sato, Hiromasa Miura, Takaaki Tanabe, Chioma Uche Okeke, Akiko Kikuchi, Seiichi Nishizawa

    Analytical chemistry　94　(22)　7814-7822　2022/06/07

    DOI： 10.1021/acs.analchem.1c05488 　

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    We have developed a new class of triplex-forming peptide nucleic acid (PNA)-based fluorogenic probes for sensing of the panhandle structure of the influenza A virus (IAV) RNA promoter region. Here, a small molecule (DPQ) capable of selectively binding to the internal loop structure was conjugated with triplex-forming forced intercalation of the thiazole orange (tFIT) probe with natural PNA nucleobases. The resulting conjugate, tFIT-DPQ, showed a significant light-up response (83-fold) upon strong (Kd = 107 nM) and structure-selective binding to the IAV RNA promoter region under physiological conditions (pH 7.0, 100 mM NaCl). We demonstrated the conjugation of these two units through the suitable spacer was key to show useful binding and fluorogenic signaling functions. tFIT-DPQ facilitated the sensitive and selective detection of IAV RNA based on its binding to the promoter region. Furthermore, we found that tFIT-DPQ could work as a sensitive indicator for screening of test compounds targeting the IAV RNA promoter region in the fluorescence indicator displacement assay.

  46. Refractory Chest Pain in Mild to Moderate Coronavirus Disease 2019 Successfully Treated with Saikanto, a Japanese Traditional Medicine.

    Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Takeshi Kanno, Michiaki Abe, Ko Onodera, Shin Takayama, Tadashi Ishii

    The Tohoku journal of experimental medicine　257　(3)　241-249　2022/05/20

    DOI： 10.1620/tjem.2022.J040 　

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    Coronavirus disease 2019 (COVID-19) causes a variety of pain symptoms in the acute phase. Severe chest pain suddenly occurs even without abnormalities on examination and is sometimes refractory to analgesics. Such pain is a clinical concern in care facilities with limited resources, and this is the first report on the use of saikanto for its treatment. In Miyagi Prefecture, Japan, COVID-19 patients with mild symptoms were admitted to a hotel that operated as an isolation facility, and their symptoms were observed. In this article, we report four cases in which chest pain comorbid with mild to moderate COVID-19 was successfully treated with saikanto, a traditional Japanese (Kampo) medicine. The patients presented with chest pain and underwent medical examination at the facility. Two patients had severe chest pain refractory to acetaminophen. Critical cardiopulmonary diseases were ruled out in all the patients, and three patients had features of pneumonia on chest radiograph. Medications, including saikanto, were administered to the patients. The patients' chest pain and other symptoms improved 1-4 days after the administration of saikanto, and they left the care facility without hospitalization. The cause of the chest pain experienced by these patients is unclear, but we speculate that it could be minimal pleural inflammation or neuropathy. Previous pharmacological studies have suggested anti-inflammatory and analgesic properties of the crude drugs that constitute saikanto. This case report suggests that saikanto could be a treatment option for chest pain refractory to analgesics in patients with mild to moderate COVID-19.

  47. Effectiveness of mRNA COVID-19 Vaccines in Japan during the Nationwide Pandemic of the Delta Variant.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Kota Ishizawa, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　257　(1)　1-6　2022/05/13

    DOI： 10.1620/tjem.2022.J012 　

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    The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remained a major global health concern in 2021. To suppress the spread of infection, mass vaccinations have been performed across countries worldwide. In Japan, vaccinations of the first and second doses for most of the nation were performed during the nationwide outbreak of the B.1.617.2 (Delta) variant with the L452R spike protein mutation, and the effectiveness of the vaccinations to suppress the spread of COVID-19 among the people in Japan remains uncertain. In this study, adults aged ≥18 years, who were in contact with patients with COVID-19 and underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) tests during August and September 2021 at a mass screening test center in Japan, were enrolled. In this period, more than 95% of the COVID-19 infections were reportedly caused by the Delta variant. As a result, a total of 784 adults with recent contact history, including 231 (29.5%) RT-PCR test-positive cases, were enrolled. The test positivity rate was lower in individuals who had been vaccinated twice than in unvaccinated individuals (12.5% vs. 39.0%, p < 0.0001), with the risk ratio of 0.32 (95% confidence interval 0.23-0.46). The vaccine effectiveness was the highest between 7-90 days after the second vaccine dose. In conclusion, two doses of mRNA COVID-19 vaccines effectively suppressed transmission in Japan during the nationwide pandemic of the Delta variant, estimated to have prevented 50-80% of the infection.

  48. 桂枝加朮附湯投薬後に多発性肺結節陰影が見つかり、投薬中止後に陰影が消失した一例

    高山 真, 菊地 章子, 石井 正

    日本東洋医学雑誌　73　(別冊)　201-201　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  49. 医学部5年生の鍼灸に対する実習前アンケートの分析

    金子 聡一郎, 菊地 章子, 有田 龍太郎, 神谷 哲治, 小野 理恵, 鈴木 聡子, 永田 真一, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　73　(別冊)　133-133　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  50. JMDC Claims Databaseを用いた産前産後の女性への漢方製剤の処方

    鈴木 聡子, 有田 龍太郎, 大澤 稔, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　73　(別冊)　198-198　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  51. 化学物質過敏症(chemical sensitivity:CS)患者の頭痛には一般更年期頭痛患者以上に水滞が関係していた

    大澤 稔, 高山 真, 菊地 章子, 有田 龍太郎, 金子 聡一郎, 神谷 哲治, 小野 理恵, 永田 真一, 清水 雅行, 齊藤 奈津美, 鈴木 聡子, 羽根田 健, 石井 正

    日本東洋医学雑誌　73　(別冊)　148-148　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  52. ヒト鼻腔粘膜上皮初代培養細胞へのインフルエンザウイルス感染に対する麻黄湯の効果に関する研究

    菊地 章子, 齊藤 奈津美, 高山 真, 石井 正

    日本東洋医学雑誌　73　(別冊)　196-196　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  53. ヒト鼻腔粘膜上皮細胞を用いた葛根湯のライノウイルス感染におけるサイトカイン産生抑制効果に関する研究

    齊藤 奈津美, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　73　(別冊)　196-196　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  54. 漢方治療の有用性の評価 QOLに及ぼす影響について

    小野 理恵, 菊地 章子, 有田 龍太郎, 高山 真, 金子 聡一郎, 齊藤 奈津美, 鈴木 聡子, 清水 雅行, 永田 真一, 大澤 稔, 神谷 哲治, 石井 正

    日本東洋医学雑誌　73　(別冊)　198-198　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  55. 大学病院漢方内科患者におけるうつ・不安スコアの変化の検討

    永田 真一, 菊地 章子, 金子 聡一郎, 小野 理恵, 鈴木 聡子, 清水 雅行, 小島 三千代, 佐々木 浩代, 有田 龍太郎, 齊藤 奈津美, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　73　(別冊)　201-201　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  56. 東北大学病院のCOVID-19軽症者等宿泊療養施設往診における初診患者の特徴と処方傾向

    有田 龍太郎, 高山 真, 小野 理恵, 菊地 章子, 大澤 稔, 齊藤 奈津美, 金子 聡一郎, 村上 慶泰, 石井 正

    日本東洋医学雑誌　73　(別冊)　207-207　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  57. COVID-19を対象とした多施設共同研究(観察研究+RCT研究)研究事務局の取り組みと課題

    桑原 安輝子, 高山 真, 有田 龍太郎, 小野 理恵, 齊藤 奈津美, 鈴木 聡子, 大澤 稔, 菊地 章子, 石井 正

    日本東洋医学雑誌　73　(別冊)　211-211　2022/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  58. COVID-19宿泊療養施設におけるステロイド剤使用経験の報告

    菊地 章子, 小野 理恵, 有田 龍太郎, 只野 恭教, 齊藤 奈津美, 大澤 稔, 阿部 倫明, 高山 真, 小野寺 浩, 石井 正

    日本内科学会雑誌　111　(Suppl.)　214-214　2022/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  59. COVID-19宿泊療養施設におけるステロイド剤使用経験の報告

    菊地 章子, 小野 理恵, 有田 龍太郎, 只野 恭教, 齊藤 奈津美, 大澤 稔, 阿部 倫明, 高山 真, 小野寺 浩, 石井 正

    日本内科学会雑誌　111　(Suppl.)　214-214　2022/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  60. Multicenter, randomized controlled trial of traditional Japanese medicine, kakkonto with shosaikotokakikyosekko, for mild and moderate coronavirus disease patients. International-journal

    Shin Takayama, Takao Namiki, Ryutaro Arita, Rie Ono, Akiko Kikuchi, Minoru Ohsawa, Natsumi Saito, Satoko Suzuki, Hajime Nakae, Seiichi Kobayashi, Tetsuhiro Yoshino, Tomoaki Ishigami, Koichiro Tanaka, Kotaro Nochioka, Airi Takagi, Masaru Mimura, Takuhiro Yamaguchi, Tadashi Ishii, Akito Hisanaga, Kazuo Mitani, Takashi Ito

    Frontiers in pharmacology　13　1008946-1008946　2022

    DOI： 10.3389/fphar.2022.1008946 　

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    The traditional Japanese (Kampo) medicine, kakkonto with shosaikotokakikyosekko, has antiviral and anti-inflammatory effects. In this randomized trial, patients with mild and moderate coronavirus disease (COVID-19) were randomly allocated to the control group receiving conventional treatment for symptom relief such as antipyretics and antitussives or the Kampo group receiving mixed extract granules of kakkonto (2.5 g) and shosaikotokakikyosekko (2.5 g) three times a day for 14 days in addition to conventional treatment. The main outcome was the number of days until total symptom relief. The secondary outcome was the number of days until each symptom's relief and whether the disease progressed to respiratory failure. We enrolled a total of 161 patients (Kampo group, n = 81; control group, n = 80). The results from Kaplan-Meier estimates of symptom relief showed that there are no significant differences between the groups. However, covariate-adjusted cumulative incidence of fever relief considering competitive risk showed that the recovery was significantly faster in the Kampo group than in the control group (HR 1.76, 95% CI 1.03-3.01). Additionally, the risk of disease progression to moderate COVID-19 requiring oxygen inhalation was lower in the Kampo group than in the control group (Risk Difference -0.13, 95% CI -0.27-0.01). No significant drug-related side effects were observed. Kakkonto with shosaikotokakikyosekko is effective for fever relief with suppression of disease progression in COVID-19 patients. Clinical Trial Registration: https://jrct.niph.go.jp/en-latest-detail/jRCTs021200020, identifier [jRCTs021200020].

  61. Response to Glucocorticoid Therapy in Patients with Mild to Moderate Coronavirus Disease 2019 at a Japanese Care Facility

    Akiko Kikuchi, Ryutaro Arita, Rie Ono, Yasunori Tadano, Natsumi Saito, Tetsuya Akaishi, Takeshi Kanno, Minoru Osawa, Shin Takayama, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　257　(2)　97-106　2022

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.2022.j022 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  62. Kampo Medicine Promotes Early Recovery From Coronavirus Disease 2019-Related Olfactory Dysfunction: A Retrospective Observational Study. International-journal

    Rie Ono, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Minoru Ohsawa, Natsumi Saito, Satoko Suzuki, Tadashi Ishii

    Frontiers in pharmacology　13　844072-844072　2022

    DOI： 10.3389/fphar.2022.844072 　

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    Background: Olfactory dysfunction is a common symptom in patients with coronavirus disease 2019, and it significantly deteriorates patients' quality of life. Effective treatments remain unknown. Purpose: To assess the effect of Japanese traditional (Kampo) medicine on coronavirus disease 2019-related olfactory dysfunction. Study Design: Retrospective observational study. Methods: In total, 87 patients aged ≥18 years with coronavirus disease 2019 and severe dysosmia or anosmia (Numeric Rating Scale, ≥7) at isolation facilities in Miyagi Prefecture, Japan, were enrolled from October 2020 to March 2021. Patients were divided into the Kampo group (N = 52) and the control group (N = 35) based on the treatment received. Changes in Numeric Rating Scale scores were evaluated at the first visit and 2 weeks after. Results: The median reduction in the olfactory dysfunction score at both 1 and 2 weeks after the first visit was significantly greater in the Kampo group (6 and 8, respectively; p = 0.03) than in the control group (3 and 7, respectively; p = 0.04). We defined improvement in olfactory dysfunction as a median reduction in the olfactory dysfunction score of ≥5. Multiple logistic regression analysis demonstrated that only Kampo treatment was significantly associated with improvement in olfactory dysfunction. Conclusion: This study suggests that Kampo medication promotes early recovery from coronavirus disease 2019-related olfactory dysfunction.

  63. Kampo medicine prescriptions for hospitalized patients in Tohoku University Hospital Peer-reviewed

    Ryo Sugimine, Yuna Kikukawa, Daisuke Kurihara, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Minoru Ohsawa, Tadashi Ishii

    Traditional & Kampo Medicine　8　(3)　221-228　2021/12

    DOI： 10.1002/tkm2.1293 　

    eISSN： 2053-4515

  64. The proton ATPase inhibitor bafilomycin A1 reduces the release of rhinovirus C and cytokines from primary cultures of human nasal epithelial cells. International-journal

    Mutsuo Yamaya, Xue Deng, Akiko Kikuchi, Mitsuru Sugawara, Natsumi Saito, Toru Kubo, Haruki Momma, Tetsuaki Kawase, Kazuyuki Nakagome, Yoshitaka Shimotai, Hidekazu Nishimura

    Virus research　304　198548-198548　2021/10/15

    DOI： 10.1016/j.virusres.2021.198548 　

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    Rhinovirus species C (RV-C) causes more severe asthma attacks than other rhinovirus species. However, the modulation of RV-C replication by drugs has not been well studied. Primary human nasal epithelial (HNE) cells cultured on filter membranes with air-liquid interface methods were infected with RV-C03, and the levels of RV-C03 RNA collected from the airway surface liquid (ASL) of HNE cells were measured with a SYBR Green assay. Pretreatment of HNE cells with the specific vacuolar H+-ATPase inhibitor bafilomycin A1 reduced the RV-C03 RNA levels in the ASL; inflammatory cytokines, including interleukin (IL)-1β, IL-6 and IL-8, in the supernatant; the mRNA expression of the RV-C receptor cadherin-related family member 3 (CDHR3) in the cells; and the number of acidic endosomes where RV-B RNA enters the cytoplasm. The levels of RV-C03 RNA in the ASL obtained from HNE cells with the CDHR3 rs6967,330 G/A genotype tended to be higher than those obtained from HNE cells with the G/G genotype. Pretreatment with the Na+/H+ exchanger inhibitor ethyl-isopropyl amiloride or either of the macrolides clarithromycin or EM900 also reduced RV-C03 RNA levels in the ASL and the number of acidic endosomes in HNE cells. In addition, significant levels of RV-A16, RV-B14 and RV-C25 RNA were detected in the ASL, and bafilomycin A1 also decreased the RV-C25 RNA levels. These findings suggest that bafilomycin A1 may reduce the release of RV-Cs and inflammatory cytokines from human airway epithelial cells. RV-Cs may be sensitive to drugs, including bafilomycin A1, that increase endosomal pH, and CDHR3 may mediate virus entry through receptor-mediated endocytosis in human airway epithelial cells.

  65. 新型コロナウイルス感染症軽症者宿泊療養施設における管理課題解決のための情報共有・往診システムの構築

    高山 真, 有田 龍太郎, 小野 理恵, 菊地 章子, 阿部 倫明, 石井 正

    日本医療・病院管理学会誌　58　(Suppl.)　183-183　2021/10

    Publisher: (一社)日本医療・病院管理学会

    ISSN： 1882-594X

    eISSN： 2185-422X

  66. Discriminatory Value of Self-reported Olfactory Dysfunction in the Prediction of Coronavirus Disease 2019.

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Akiko Kikuchi, Junichi Tanaka, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    Internal medicine (Tokyo, Japan)　60　(18)　2905-2910　2021/09/15

    DOI： 10.2169/internalmedicine.7238-21 　

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    Objective Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), remains the world's largest public health concern in 2021. A history of close contact with infectious patients is a factor that predicts a positive SARS-CoV-2 test result. Meanwhile, the precise predictive value of symptoms suggestive of COVID-19 has not been fully elucidated. This study aimed to clarify the predictive and discriminatory value of each clinical symptom suggestive of COVID-19. Methods This study enrolled participants who were tested for SARS-CoV-2 by reverse transcription polymerase chain reaction using a nasopharyngeal swab between November 2020 and January 2021. All enrolled patients were evaluated for data regarding the presence and closeness of contact with infectious patients and comprehensive clinical features (i.e., fever, cough, dyspnea, fatigue, dysosmia, and dysgeusia). Results Among the 1,744 tested participants, 144 tested positive for SARS-CoV-2. In the test-positive group, self-reported cough, fatigue, dysosmia, and dysgeusia were significant predictors of COVID-19, independent from a history of close contact. In particular, the presence of dysosmia was the strongest predictor of COVID-19 in both univariate and multivariate analyses. Among the 42 patients with self-reported dysosmia, 25 (59.5%) were SARS-CoV-2 test-positive. Self-reported dysosmia was reported by 25 (17.4%) of the 144 patients who tested positive for SARS-CoV-2, and 15 (60.0%) of the 25 COVID-19 patients with dysosmia had accompanying dysgeusia. Conclusion The presence of dysosmia was reported by 10-25% of patients with COVID-19, and is a significant predictor of COVID-19 infection, independent from a history of close contact.

  67. COVID-19関連嗅覚障害に対する漢方治療の有効性

    小野 理恵, 有田 龍太郎, 高山 真, 菊地 章子, 石井 正

    日本感染症学会東日本地方会学術集会・日本化学療法学会東日本支部総会合同学会プログラム・抄録集　70回・68回　187-187　2021/09

    Publisher: 日本感染症学会東日本地方会・日本化学療法学会東日本支部

  68. 葛根湯加川きゅう辛夷がCOVID-19関連嗅覚障害の症状緩和に寄与した可能性を示す5症例報告

    高山 真, 小野 理恵, 有田 龍太郎, 齊藤 奈津美, 鈴木 聡子, 菊地 章子, 大澤 稔, 石井 正

    和漢医薬学会学術大会要旨集　38回　81-81　2021/09

    Publisher: (一社)和漢医薬学会

  69. 漢方医学の卒前臨床実習における体質チェックアンケートの内容と妥当性の検討

    神谷 哲治, 有田 龍太郎, 金子 聡一郎, 菊地 章子, 大澤 稔, 沼田 健裕, 齊藤 奈津美, 鈴木 聡子, 小野 理恵, 永田 真一, 高山 真, 石井 正

    医学教育　52　(Suppl.)　178-178　2021/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  70. 正常眼圧緑内障に対する当帰芍薬散の短期服用効果

    有田 龍太郎, 高山 真, 菊地 章子, 金子 聡一郎, 齊藤 奈津美, 石井 正

    日本東洋医学雑誌　71　(別冊)　148-148　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  71. 原因不明の肛門直腸痛に鍼治療が有効だった一例

    神谷 哲治, 小野 理恵, 菊地 章子, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　71　(別冊)　156-156　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  72. 黄連解毒湯と小柴胡湯が有効であったカルムスチン脳内留置用剤による難治性薬剤熱の一例

    鈴木 聡子, 高山 真, 有田 龍太郎, 菊地 章子, 石井 正

    日本東洋医学雑誌　71　(別冊)　188-188　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  73. 大学病院漢方内科の初診患者におけるうつ・不安スコアの検討

    菊地 章子, 小野 理恵, 永田 真一, 小島 三千代, 鈴木 聡子, 佐々木 浩代, 清水 雅行, 有田 龍太郎, 齊藤 奈津美, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　71　(別冊)　198-198　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  74. 慢性一次疼痛患者の漢方治療 単施設での後方視的検討

    小野 理恵, 高山 真, 菊地 章子, 有田 龍太郎, 齋藤 奈津美, 小島 三千代, 永田 真一, 鈴木 聡子, 清水 雅行, 沼田 健裕, 大澤 稔, 石井 正

    日本東洋医学雑誌　71　(別冊)　200-200　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  75. COVID-19 transmission in group living environments and households. International-journal

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Ko Onodera, Tadashi Ishii

    Scientific reports　11　(1)　11616-11616　2021/06/02

    DOI： 10.1038/s41598-021-91220-4 　

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    The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the world's largest public health concern. This study evaluated COVID-19 transmission risks in people in group living environments. A total of 4550 individuals with a history of recent contact with patients at different places (dormitory/home/outside the residences) and levels (close/lower-risk) were tested for SARS-CoV-2 viral RNA using a nasopharyngeal swab test between July 2020 and May 2021. The test-positive rate was highest in individuals who had contact in dormitories (27.5%), but the rates were largely different between dormitories with different infrastructural or lifestyle features and infection control measures among residents. With appropriate infection control measures, the secondary transmission risk in dormitories was adequately suppressed. The household transmission rate (12.6%) was as high as that of close contact outside the residences (11.3%) and accounted for > 60% of the current rate of COVID-19 transmission among non-adults. Household transmission rates synchronized to local epidemics with changed local capacity of quarantining infectious patients. In conclusion, a group living environment is a significant risk factor of secondary transmission. Appropriate infection control measures and quarantine of infectious residents will decrease the risk of secondary transmission in group living environments.

  76. Impacts of Natural Environmental Factors and Prevalence of Airway Symptoms on the Local Spread of COVID-19: A Time-Series Analysis in Regional COVID-19 Epidemics.

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Noriko Sugawara, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku journal of experimental medicine　254　(2)　89-100　2021/06

    DOI： 10.1620/tjem.254.89 　

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    Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the world's largest public health concern in 2021. This study evaluated the associations of the prevalence of airway symptoms among the tested individuals and data regarding the natural environmental factors with the weekly number of newly diagnosed COVID-19 patients in Sendai City (Nt). For the derivatives of the screening test results, data from individuals with a contact history who underwent nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) testing between July 2020 and April 2021 (6,156 participants, including 550 test-positive patients) were used. The value of Nt correlated with the weekly RT-PCR test-positive rate after close contact, prevalence of cough symptoms in test-positive individuals or in test-negative individuals, lower air temperature, lower air humidity, and higher wind speed. The weekly test-positive rate correlated with lower air humidity and higher wind speed. In cross-correlation analyses, natural environmental factors correlated with the regional epidemic status on a scale of months, whereas the airway symptoms among non-COVID-19 population affected on a scale of weeks. When applying an autoregression model to the serial data of Nt, large-scale movements of people were suggested to be another factor to influence the local epidemics on a scale of days. In conclusion, the prevalence of cough symptoms in the local population, lower air humidity or higher wind speed, and large-scale movements of people in the locality would jointly influence the local epidemic status of COVID-19.

  77. Treatment of COVID-19-Related Olfactory Disorder Promoted by Kakkontokasenkyushin'i: A Case Series.

    Shin Takayama, Ryutaro Arita, Rie Ono, Natsumi Saito, Satoko Suzuki, Akiko Kikuchi, Minoru Ohsawa, Yasunori Tadano, Tetsuya Akaishi, Junichi Tanaka, Takeshi Kanno, Michiaki Abe, Ko Onodera, Tadashi Ishii

    The Tohoku journal of experimental medicine　254　(2)　71-80　2021/06

    DOI： 10.1620/tjem.254.71 　

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    Olfactory disorders are one of the characteristic symptoms of the coronavirus disease of 2019 (COVID-19), which causes infection and inflammation of the upper and lower respiratory tract. To our knowledge, there are no treatments for COVID-19-related olfactory disorder. Here, we report five olfactory disorder cases in COVID-19, treated using the Japanese traditional (Kampo) medicine, kakkontokasenkyushin'i. We treated five patients with mild COVID-19 at an isolation facility using Kampo medicine, depending on their symptoms. Patients with the olfactory disorder presented with a blocked nose, nasal discharge or taste impairment. Physical examination using Kampo medicine showed similar findings, such as a red tongue with red spots and sublingual vein congestion, which presented as blood stasis and inflammation; thus, we prescribed the Kampo medicine, kakkontokasenkyushin'i. After administration, the numeric rating scale scores of the smell impairment improved within 3 days from 9 to 3 in case 1, from 10 to 0 in case 2, from 9 to 0 in case 3, from 5 to 0 in case 4, and from 9 to 0 within 5 days in case 5. Following the treatment, other common cold symptoms were also alleviated. Kakkontokasenkyushin'i can be used for treating nasal congestion, rhinitis, and inflammation in the nasal mucosa. The olfactory disorder in COVID-19 has been reportedly associated with inflammation and congestion, especially in the olfactory bulb and olfactory cleft. Kakkontokasenkyushin'i may be one of the treatment alternatives for the olfactory disorder with rhinitis in patients with COVID-19.

  78. Two Cases of Multiple Chemical Sensitivity Successfully Treated With Kampo Medicine. International-journal Peer-reviewed

    Minoru Ohsawa, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Natsumi Saito, Sachiko Hojo, Tadashi Ishii, Nobuo Yaegashi

    Alternative therapies in health and medicine　27　(3)　54-58　2021/05

    ISSN： 1078-6791

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    Context: Multiple chemical sensitivity (MCS) is a chronic disorder in which minimal but sustained exposure to particular chemicals causes headaches, vertigo, and multiple other symptoms. Up to 10% of cases are clinically unresponsive to treatment. Kampo medicines include multiple crude components with many applications for organ disorders. Objective: The research team aimed to assess the efficacy of goreisan, a Japanese Kampo medicine, for 2 patients diagnosed with intractable cases of MCS. Design: The research team conducted case studies with 2 female patients. Setting: The study took place at the Kampo clinic in the Department of Gynecology and Obstetrics at the Japanese Red Cross Maebashi Hospital in Maebashi, Gunma, Japan. Participants: The participants were patients at the clinic. Intervention: The first participant received the Kampo formula goreisan for her headaches and keigairengyoto for her mucosal discomfort; the second received goreisan for her headaches and kakkonto to reduce her shoulder-muscle stiffness. The participants received Kampo treatments for one month. Outcome measures: The first participant's MCS symptoms were evaluated with the Quick Environment Exposure Sensitivity Inventory questionnaire (QEESI); the second using a numeric rating scale (NRS). Results: After the Kampo treatments, the first participant's QEESI scores for chemical intolerance, symptom severity, and life impact were reduced from 47, 92, and 76 to 37, 39, and 55 points, respectively. The second participant's NRS scores were likewise reduced from 6, 8, and 8 out of 10 to 1, 2, and 1 out of 10. Symptoms were relieved in both patients, and didn't recur. Conclusions: These results highlight the potential benefits of Kampo medicine for the treatment of intractable MCS. Further investigations will be needed to confirm the mechanism of action, thereby improving the understanding of the effectiveness of Kampo medicine for MCS therapy.

  79. Retrospective study revealed that Zn relate to improvement of swallowing function in the older adults. International-journal

    Yumika Seki, Kota Ishizawa, Tetsuya Akaishi, Michiaki Abe, Koji Okamoto, Junichi Tanaka, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Mariko Miyazaki, Hideo Harigae, Mayumi Sato, Masaya Hoshi, Kazuaki Hatsugai, Tadashi Ishii

    BMC geriatrics　21　(1)　279-279　2021/04/26

    DOI： 10.1186/s12877-021-02224-8 　

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    BACKGROUND: Zinc is an essential micronutrient for maintaining biological activity. The level of zinc in the blood is known to decrease with age, especially in those over 75 years of age. In older adults patients with impaired functional status, aspiration pneumonia based on dysphagia often becomes problematic. However, the relationship between zinc deficiency and swallowing function has not been studied before. METHODS: A total of 52 older adults subjects (15 males and 37 females) living in a nursing home were enrolled for this study. At the time of enrollment, data of gender, age, body weight, serum zinc levels, serum albumin levels, and the time in a simple 2-step swallowing provocation test (S-SPT) were collected. In patients with serum zinc levels < 60 μg/dL, we initiated 2 months of oral zinc supplementation therapy with a 34 mg/day zinc load. Those who underwent zinc supplementation were re-evaluated after the treatment period and serum zinc levels and S-SPT time were measured. RESULTS: At the time of enrollment, serum zinc level was significantly correlated with serum albumin levels (Pearson's R = 0.58, p < 0.0001) and time in the S-SPT (Spearman's rho = - 0.32, p = 0.0219). Twenty-five of the 52 patients had zinc deficiency with a serum zinc level < 60 μg/dL. After 2 months of oral zinc supplementation, both serum zinc levels (p < 0.0001) and time in the S-SPT (p = 0.04) significantly improved. Meanwhile, serum albumin level (p = 0.48) or body weight (p = 0.07) did not significantly change following zinc supplementation. Zinc supplementation significantly improved swallowing function, especially in the older adults who had comorbid dysphagia and zinc deficiency. CONCLUSIONS: Zinc deficiency is associated with compromised swallowing function in older adults patients with impaired general functions. Oral zinc supplementation can alleviate dysphagia in older adults patients with zinc deficiency even though this is a retrospective study. Further study will be needed to confirm this positive effect.

  80. Basic pharmacological mechanisms and clinical evidence of the efficacy of hochuekkito against infectious diseases and its potential for use against COVID‐19

    Shin Takayama, Akiko Kikuchi, Toshiaki Makino, Mosaburo Kainuma, Takao Namiki, Takashi Ito

    Traditional & Kampo Medicine　8　(1)　3-21　2021/04

    Publisher: Wiley

    DOI： 10.1002/tkm2.1264 　

    ISSN： 2053-4515

    eISSN： 2053-4515

  81. Predictors of SARS-CoV-2 Positivity Based on RT-PCR Swab Tests at a Drive-Through Outpatient Clinic for COVID-19 Screening in Japan.

    Tadashi Ishii, Shigeki Kushimoto, Yukio Katori, Shigeo Kure, Kaoru Igarashi, Motoo Fujita, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tetsuya Akaishi

    The Tohoku journal of experimental medicine　253　(2)　101-108　2021/02

    DOI： 10.1620/tjem.253.101 　

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    In response to the COVID-19 pandemic caused by SARS-CoV-2 in 2020, we conducted drive-through nasopharyngeal swab testing for COVID-19 in Sendai city, Japan, since April 2020. All tested individuals were judged in advance by public health centers for the necessity of undergoing the test with possible contact history and/or symptoms suggestive of COVID-19. In this study, to identify the predictors of SARS-CoV-2 test positivity for more efficient and evidenced selection of suspected individuals, we enrolled 3,540 consecutive individuals, tested in the first 7 months of the testing program, with data regarding to the history of close contact with COVID-19 patients, including those involved in cluster outbreaks. This cohort included 284 foreign students (257 males and 27 females) from a vocational school involved in the largest cluster outbreak in the area. Close contact history was present in 952 (26.9%) of the participants. The reverse transcription-polymerase chain reaction (RT-PCR) test results showed that 164 participants (4.6%) were positive and 3,376 participants (95.4%) were negative for the SARS-CoV-2 nucleocapsid gene (N2). In the univariate and multivariate analyses, history of close contact with COVID-19 patients, higher age, cough symptoms, and non-native ethnicity were predictors for SARS-CoV-2 test positivity. However, the significance of age and foreign nationality disappeared or declined upon excluding the foreign students from the aforementioned largest cluster outbreak. In conclusion, a history of close contact with COVID-19 patients and the presence of cough symptoms are significant predictors of SARS-CoV-2 test positivity.

  82. Prescription of Kampo Formulations for Pre-natal and Post-partum Women in Japan: Data From an Administrative Health Database. International-journal

    Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii

    Frontiers in nutrition　8　762895-762895　2021

    DOI： 10.3389/fnut.2021.762895 　

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    Introduction: Traditional Japanese (Kampo) medicines are often prescribed for women in Japan before, during, and after pregnancy. However, detailed information on the actual frequency of use and safety of Kampo preparations during pregnancy is lacking. Aim: To investigate the frequency of prescription of Kampo medicines for pregnant women in Japan. Methods: Information on Kampo medicines prescribed during outpatient care and hospitalization of selected mothers from January 2005 to August 2016 were extracted from the Japan Medical Data Center (Tokyo, Japan), which is a large claims database. Results: Of the 33,941 subscribers identified from the database, 16,294 (48%) received at least one prescription of a Kampo medicine. Kakkonto was the formula most prescribed during the study period, followed by shoseiryuto and tokishakuyakusan. In the 180 days before pregnancy, the most prescribed medicine was tokishakuyakusan, followed by kakkonto and shoseiryuto. Shoseiryuto, tokishakuyakusan, and kakkonnto were the formulae most prescribed during pregnancy. The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito. Conclusions: Information in the Japanese insurance system shows that Kampo medicines are often prescribed during pregnancy. Most of these prescriptions are generally used for the treatment of common cold. Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan.

  83. COVID-19 Transmission at Schools in Japan

    Tetsuya Akaishi, Shigeki Kushimoto, Yukio Katori, Noriko Sugawara, Kaoru Igarashi, Motoo Fujita, Shigeo Kure, Shin Takayama, Michiaki Abe, Junichi Tanaka, Akiko Kikuchi, Yoshiko Abe, Hiroyuki Imai, Yohei Inaba, Yoko Iwamatsu-Kobayashi, Takashi Nishioka, Ko Onodera, Tadashi Ishii

    The Tohoku Journal of Experimental Medicine　255　(3)　239-246　2021

    Publisher: Tohoku University Medical Press

    DOI： 10.1620/tjem.255.239 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  84. Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients. International-journal

    Masakazu Kitahara, Shin Takayama, Tetsuya Akaishi, Akiko Kikuchi, Tadashi Ishii

    Frontiers in pharmacology　12　683171-683171　2021

    DOI： 10.3389/fphar.2021.683171 　

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    Background: Methicillin-resistant Staphylococcus aureus (MRSA) colonization can lead to MRSA pneumonia or other infections in compromised hosts, and invasive MRSA infections lead to significant morbidity and mortality. The present observational study elucidated whether administration of hochuekkito (HET) can prevent MRSA colonization in the upper respiratory tract and support recovery in acute stroke patients. Methods: In this retrospective, observational study, 73 acute stroke patients admitted to Kenwakai Hospital between April 2007 and December 2019 who did not require emergency surgery during this period were enrolled. Conventional treatment was provided to all patients, depending on their condition, and 7.5 g/day of HET was administered to the patients who could take the medicine via nasogastric tube or orally in three divided doses for three months. Bacterial cultures from laryngeal swabs and sputum were evaluated every week. We evaluated the presence of MRSA infection or another infectious disease within 30 days of admission; modified Rankin Scale scores, which assesses the independent living skills after stroke at three months after admission; and blood biomarkers (white blood cell count, albumin levels, C-reactive protein levels, and hemoglobin levels). Results: In total, 73 patients (HET group, n = 41; non-HET group, n = 32) were enrolled in the study. MRSA detection was significantly less likely in the HET group than in the non-HET group (p = 0.0497). The incidence of infectious diseases was significantly lower in the HET group than in the non-HET group (p = 0.0096), and the modified Rankin Scale score at three months was also significantly lower in the HET group than in the non-HET group (p = 0.033). The white blood cell count, and serum C-reactive protein levels did not differ between those who were treated with HET and those who were not. However, serum albumin and hemoglobin levels improved slightly between month one and month three after admission only in those who were treated with HET. Conclusion: Our results indicate that the administration of HET may contribute to the prevention of MRSA colonization and promote rehabilitation in stroke patients.

  85. Kampo Medicine Treatment for Advanced Pancreatic Cancer: A Case Series. International-journal

    Masayuki Shimizu, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Rie Ono, Kota Ishizawa, Tadashi Ishii

    Frontiers in nutrition　8　702812-702812　2021

    DOI： 10.3389/fnut.2021.702812 　

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    Aims: The present report aims to investigate the use of Kampo medicine for advanced pancreatic cancer patients in order to prolong survival. Methods: We retrospectively reviewed medical records of patients with pancreatic cancer who presented to our Shimizu Clinic from 2000 to 2020. Patients who survived at least twice as long as the initial prognostic estimate were selected and their treatment was reviewed. The Kampo formula and crude drugs were selected according to the Kampo diagnosis and treatment strategy, which included qi and blood supplementation; qi, blood and water smoothing; and inflammation (termed "heat") and cancer suppression. Results: Ten patients aged 45-80 years (six males and four females) with stage IV advanced cancer were selected. All patients received hozai, which is a tonic formula, of juzentaihoto (JTT) or hochuekkito (HET) decoction. Anti-cancer crude drugs were included in the decoctions of nine patients. At the first visit, the estimated life expectancy for all patients was no more than 1 year; however, treatment with Western and Kampo medicine led to a relatively long survival period of over 2 years. Three patients were still living at the time of this writing, more than 2, 6, and 14 years after treatment initiation. Conclusion: Our results suggest that Kampo medicine may be useful for disease control and supportive care for patients with advanced pancreatic cancer.

  86. Bukuryoingohangekobokuto may improve recurrent aspiration pneumonia in patients with brain damage and reduce the caregiver burden. International-journal

    Shin Takayama, Ryutaro Arita, Akiko Kikuchi, Tadashi Ishii

    Journal of family medicine and primary care　10　(1)　558-560　2021/01

    DOI： 10.4103/jfmpc.jfmpc_1627_20 　

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    A 17-year-old girl with hypoxic encephalopathy was hospitalized over four times in a year because of recurrent aspiration pneumonia (AP). She had dysphagia and reduced cough reflex as sequelae of brain damage. To prevent aspiration, a gastric tube was placed for feeding, but it did not reduce the frequency of AP because the gastroesophageal reflux caused backflow. However, after the Kampo medicine bukuryoingohangekobokuto (BRIHK) was added to the prescriptions, her sputum and gastroesophageal reflux was remarkably reduced. BRIHK is a Kampo medicine that confers multiple benefits such as improving swallowing and cough reflexes, reducing sputum, and improving gastric emptying. Subsequently, the frequency of sputum suction reduced from every 15 min to 30 min, thus reducing the burden on her mother. As a result, she has never been hospitalized for AP in the 7 years after treatment. Overall, BRIHK may be a treatment of choice for similar patients.

  87. Herbal medicine-induced multiple pulmonary pseudotumors. International-journal

    Shin Takayama, Tetsuya Akaishi, Masakazu Hanagama, Yuko Itakura, Ryutaro Arita, Akiko Kikuchi, Tadashi Ishii

    Journal of family medicine and primary care　9　(7)　3773-3775　2020/07

    DOI： 10.4103/jfmpc.jfmpc_420_20 　

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    Japanese herbal medicines (HMs) cause adverse drug reactions (ADRs); however, solid nodule formation is uncommon. In this report, we aimed to show that ADRs with HM can mimic lung cancer. A 63-year-old man complained of back pain. His physician prescribed a traditional Japanese HM, Keishikajutsubuto, which alleviated his symptoms. After 4 weeks, a chest radiograph showed multiple lung nodules that were absent 6 months earlier; the patient did not have cough, fever, or dyspnea. Computed tomography (CT) showed multiple, bilateral lung nodules; however, blood tests and lung biopsy showed no abnormalities, ruling out interstitial pneumonia and lung cancer. Three months after the HM was discontinued, CT showed resolution of the lesions. Interstitial pneumonia was reported as a side effect of HM; however, no such side effect was reported for Keishikajutsubuto. When a patient presents with multiple lung nodules, a side effect of HM should be considered as a differential diagnosis.

  88. Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome with chronic febricula using the traditional Japanese medicine Shosaikoto Peer-reviewed

    Takehiro Numata, Kazuki Miura, Tetsuya Akaishi, Ryutaro Arita, Kota Ishizawa, Natsumi Saito, Hiroyo Sasaki, Akiko Kikuchi, Shin Takayama, Muneshige Tobita, Tadashi Ishii

    Internal Medicine　59　(2)　297-300　2020/01/15

    DOI： 10.2169/internalmedicine.3218-19 　

    ISSN： 0918-2918

    eISSN： 1349-7235

  89. Kampo Medicine for Various Aging-Related Symptoms: A Review of Geriatric Syndrome. International-journal Peer-reviewed

    Shin Takayama, Naoki Tomita, Ryutaro Arita, Rie Ono, Akiko Kikuchi, Tadashi Ishii

    Frontiers in nutrition　7　86-86　2020

    DOI： 10.3389/fnut.2020.00086 　

    eISSN： 2296-861X

  90. Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor: A case report International-journal Peer-reviewed

    Satoko Suzuki, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Michiaki Abe, Ryuta Saito, Masayuki Kanamori, Teiji Tominaga, Tadashi Ishii

    Explore　2020

    DOI： 10.1016/j.explore.2020.08.014 　

    ISSN： 1550-8307

    eISSN： 1878-7541

  91. Integrative therapy for advanced pancreatic cancer using Kampo and western medicine: A case report International-journal Peer-reviewed

    Masayuki Shimizu, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Rie Ono, Kota Ishizawa, Tadashi Ishii

    Explore　2020

    DOI： 10.1016/j.explore.2020.07.003 　

    ISSN： 1550-8307

    eISSN： 1878-7541

  92. Development of a medical education program with abdominal palpation simulators to support the understanding of traditional Japanese (kampo) medicine in beginners Peer-reviewed

    Ryutaro Arita, Takehiro Numata, Natsumi Saito, Shin Takayama, Takafumi Togashi, Soichiro Kaneko, Akiko Kikuchi, Minoru Ohsawa, Tetsuharu Kamiya, Michiaki Abe, Tadashi Ishii

    Traditional & Kampo Medicine　6　(3)　148-155　2019/10

    Publisher: Wiley

    DOI： 10.1002/tkm2.1230 　

  93. 漢方エビデンスレポートからみえる漢方薬の臨床研究の現状と変遷

    乙竹 秀明, 東 いぶき, 久保川 哲, 近藤 亮一郎, 有田 龍太郎, 沼田 健裕, 大澤 稔, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　70　(4)　419-429　2019/10

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  94. Daisaikoto for shoulder stiffness and related changes in stool condition: Retrospective study Peer-reviewed

    Minoru Ohsawa, Shin Takayama, Akiko Kikuchi, Ryutaro Arita, Natsumi Saito, Yuka Ikeno, Hitoshi Nishikawa, Hiroyo Sasaki, Michiyo Kojima, Masayuki Shimizu, Takehiro Numata, Kota Ishizawa, Tadashi Ishii

    Traditional & Kampo Medicine　6　(2)　105-108　2019/08/16

    Publisher: Wiley

    DOI： 10.1002/tkm2.1219 　

  95. Spontaneous Regression of Recurrent Undifferentiated Carcinoma of the Endometrium. Peer-reviewed

    Tadashi Ishii, Shin Takayama, Michiaki Abe, Hitoshi Kuroda, Junichi Tanaka, Takehiro Numata, Akiko Kikuchi, Minoru Ohsawa, Souichiro Kaneko, Natsumi Saito, Ryutaro Arita, Yuko Itakura

    Internal medicine (Tokyo, Japan)　58　(11)　1649-1653　2019/06/01

    DOI： 10.2169/internalmedicine.0376-17 　

    ISSN： 0918-2918

  96. Successful treatment of intractable menstrual migraine with the traditional herbal medicine tokishakuyakusan. Peer-reviewed

    Tetsuya Akaishi, Shin Takayama, Minoru Ohsawa, Akiko Kikuchi, Ryutaro Arita, Ichiro Nakashima, Masashi Aoki, Tadashi Ishii

    Journal of general and family medicine　20　(3)　118-121　2019/05

    DOI： 10.1002/jgf2.242 　

    ISSN： 2189-6577

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    In this report, we present the successful treatment of five consecutive cases of premenopausal women suffering from severe menstrual migraine with tokishakuyakusan (TSS). Two patients were complicated by tension-type headache (TTH), and another patient was by medication overuse headache (MOH). The effects of triptans were limited in all of them. After starting TSS, they showed dramatic improvement in the severity and frequency of their attacks. The patients with TTH and MOH also showed dramatic improvement in their symptoms. TSS could be a promising alternative choice for patients with intractable menstruation-related headaches that are refractory to conventional treatments, including triptans.

  97. Responder Analysis of Daikenchuto Treatment for Constipation in Poststroke Patients: A Subanalysis of a Randomized Control Trial. Peer-reviewed

    Arita R, Numata T, Takayama S, Obara T, Kikuchi A, Ohsawa M, Suzuki A, Yokota T, Kusaba M, Yaegashi N, Ishii T

    Journal of evidence-based integrative medicine　24　2515690X19889271　2019/01

    DOI： 10.1177/2515690X19889271 　

    eISSN： 2515-690X

  98. Clinical Characteristics of Chronic Otolaryngeal Patients Treated with Kampo Medicines

    西川 仁, 高山 真, 菊地 章子, 沼田 健裕, 池野 由佳, 金子 聡一郎, 神谷 哲治, 有田 龍太郎, 齊藤 奈津美, 大澤 稔, 小島 三千代, 佐々木 浩代, 山下 和良, 石井 正

    日本東洋医学雑誌　70　(1)　18-24　2019/01

    Publisher: 日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  99. 耳鼻咽喉科領域の症状に対する漢方治療例の検討

    西川 仁, 高山 真, 菊地 章子, 沼田 健裕, 池野 由佳, 金子 聡一郎, 神谷 哲治, 有田 龍太郎, 齊藤 奈津美, 大澤 稔, 小島 三千代, 佐々木 浩代, 山下 和良, 石井 正

    日本東洋医学雑誌　70　(1)　18-24　2019/01

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  100. Validity of Hamilton Depression Rating Scale for assessment of depressive state of new outpatients at a university hospital general medical unit

    阿部 倫明, 野崎 裕之, 中川 高, 八木橋 真央, 石沢 興太, 奥田 拓史, 赤石 哲也, 田中 淳一, 大澤 稔, 沼田 健裕, 菊地 章子, 高山 真, 奈良 正之, 小野寺 浩, 富田 博秋, 石井 正

    日本病院総合診療医学会雑誌　14　(6)　556-563　2018/11

    Publisher: 日本病院総合診療医学会

    ISSN： 2185-8136

  101. Clinical Practice Guidelines and Evidence for the Efficacy of Traditional Japanese Herbal Medicine (Kampo) in Treating Geriatric Patients. International-journal Peer-reviewed

    Shin Takayama, Ryutaro Arita, Akiko Kikuchi, Minoru Ohsawa, Soichiro Kaneko, Tadashi Ishii

    Frontiers in nutrition　5　66-66　2018

    DOI： 10.3389/fnut.2018.00066 　

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    Frailty is defined as a state of increased vulnerability to poor resolution of homeostasis following stress, which increases the risk of adverse outcomes such as falls, delirium, and disability in the elderly. Recently in Japan, clinical practice guidelines (CPG) have recommended kampo treatment. We conducted a search for reports on Japanese CPG and kampo medicine in the treatment of symptoms in the elderly. The search was performed using the databases PubMed, Ichushi Web, J-Stage, Japan Medical Publishers Association, Medical Information Network Distribution Service, and CPG containing kampo products in Japan; reports from January 1st, 2012 to October 31st, 2017 were reviewed. Over the past 5 years, nine CPGs have recommended kampo treatment based on the evidence for improvement in skin symptoms, cough, gastro-intestinal dysfunction, urinary dysfunction, and dementia. Treatments with kampo medicine are performed depending on the coexistence of manifestations based on the original kampo concept, i.e., cognitive dysfunction and dementia with sarcopenia showing urinary disorder. Each kampo formula includes multiple crude drugs that have several pharmacological functions; these drugs include alkaloids, glycosides, and polysaccharides. Thus, kampo formula has an effect on multiple organs and coordinates the relationship between the brain, endocrine system, immune system, and skeletal muscles. Kampo treatment can be considered as supporting holistic medicine in elderly individuals with frailty.

  102. A Report on an Annual Kampo Medicine Conference Held by Medical Students in the Hokkaido and Tohoku Areas

    OKADA Shohei, YASUI Hiromichi, YAEGASHI Minoru, KUBO Kahori, KANEKO Soichiro, KAMIYA Tetsuharu, SAITO Natsumi, ARITA Ryutaro, WATANABE Hidekazu, NISHIKAWA Hitoshi, IKENO Yuka, OMATA Fumiya, TANAKA Junichi, OHSAWA Minoru, KIKUCHI Akiko, NUMATA Takehiro, KURODA Hitoshi, ABE Michiaki, TAKAYAMA Shin, ISHII Tadashi, TOGASHI Takafumi, OKUDA Takahisa, MIYAMOTO Tesshin, OOSUGA Miho, TANAKA Kohei, ISHIYAMA Mami, AISO Aiseio

    Kampo Medicine　68　(1)　72-78　2017/01

    Publisher: 一般社団法人 日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

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    &lt;p&gt;Since students who would like to study Kampo medicine more have no opportunity to communicate each other in Northern Japanese Universities, we newly started joint study conferences held by medical students in 2013. The objectives of this paper are to report on these annually held student-based Kampo study conferences in the Hokkaido and Tohoku areas, and the ways each university studies Kampo medicine. In the conference, the students reported on their club activities. Then they studied the history of Kampo medicine and simulation of abdominal diagnosis, and performed group work on case reports together. The number of student participants in these conferences has tripled over 3 years from 18 to 58 (for a total of 111 participants). All members were satisfied with the content. And this reflects medical students&#039; need for a wider perception of Kampo medicine, rather than a limited one gained in their university club activities. We hope this conference will play a major role in other nationwide student-based Kampo study conferences in the years to come.&lt;/p&gt;

  103. Improving the Quality of Postgraduate Education in Traditional Japanese Kampo Medicine for Junior Residents: An Exploratory Survey Conducted in Five Institutions in the Tohoku Area Peer-reviewed

    Shin Takayama, Seiichi Kobayashi, Soichiro Kaneko, Masao Tabata, Shinya Sato, Keiichi Ishikawa, Saya Suzuki, Ryutaro Arita, Natsumi Saito, Tetsuharu Kamiya, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Satoru Ishibashi, Nobuo Yaegashi, Tadashi Ishii

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(3)　235-242　2016/11

    DOI： 10.1620/tjem.240.235 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  104. Preliminary study of the effects of orengedokuto on breath alcohol concentration. Peer-reviewed

    Suzuki S, Ojima T, Takayama S, Nakano Y, Nawa D, Saito N, Arita R, Kaneko S, Kamiya T, Mikami N, Kawamura T, Nakamura T, Watanabe H, Nishikawa H, Ikeno Y, Tanaka J, Ohsawa M, Kikuchi A, Numata T, Kuroda H, Abe M, Ishii T

    Traditional and Kampo medicine　3　(2)　167-169　2016/10

  105. Questionnaire-Based Development of an Educational Program of Traditional Japanese Kampo Medicine Peer-reviewed

    Shin Takayama, Seiichi Ishii, Fumie Takahashi, Natsumi Saito, Ryutaro Arita, Soichiro Kaneko, Masashi Watanabe, Tetsuharu Kamiya, Hidekazu Watanabe, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Takashi Takeda, Nobuo Yaegashi, Tadashi Ishii

    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(2)　123-130　2016/10

    DOI： 10.1620/tjem.240.123 　

    ISSN： 0040-8727

    eISSN： 1349-3329

  106. Development of a questionnaire for the diagnosis of Qi stagnation. International-journal Peer-reviewed

    Reina Okitsu, Koh Iwasaki, Yasutake Monma, Shin Takayama, Soichiro Kaneko, Gungfan Shen, Masashi Watanabe, Tetsuharu Kamiya, Ayane Matsuda, Akiko Kikuchi, Satomi Takahashi, Takashi Seki, Satoru Nagase, Takashi Takeda, Sang-Kwan Moon, Woo-Sang Jung, Seong-Uk Park, Kiho Cho, Nobuo Yaegashi, Seng-Hoon Choi

    Complementary therapies in medicine　20　(4)　207-17　2012/08

    DOI： 10.1016/j.ctim.2011.12.005 　

    ISSN： 0965-2299

  107. The Present State of Integrative Medicine at Four Medical Facilities in Germany

    高山真, 岩崎鋼, 渡部正司, 神谷哲治, 平野篤, 松田綾音, 沼田健裕, 楠山寛子, 沖津玲奈, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    日本東洋医学雑誌　63　(4)　275-282　2012/07/20

    Publisher: The Japan Society for Oriental Medicine

    DOI： 10.3937/kampomed.63.275 　

    ISSN： 0287-4857

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    Europe has a long history with its own traditional medicines. In Germany, the practice of traditional European and Asian medicine along with modern medicine is called Integrative Medicine. The pain clinics at Munich University, TCM Klinik Bad Kotzting, Immanuel Klankenhaus and Zen Haus Klinik are well-known centers of Integrative Medicine in Germany. We visited these hospitals and clinics and report on the state of their treatment.<BR>Four-week programs in chronic pain, traditional Chinese medicine, natural therapy, and traditional Japanese medicine with aromatherapy are given at these facilities. Moreover, Complementary and Alternative medicines are widely covered by public or private insurance. And one reason for the spread of Integrative Medicine may be these social conditions, in addition to historical background.

  108. Role of oriental medicine in the great East Japan earthquake Peer-reviewed

    S. Takayama, R. Okitsu, K. Iwasaki, M. Watanabe, T. Kamiya, A. Hirano, A. Matsuda, Y. Monma, T. Numata, H. Kusuyama, S. Hirata, A. Kikuchi, T. Seki, T. Takeda, N. Yaegashi

    Deutsche Zeitschrift fur Akupunktur　55　(2)　15-18　2012

    Publisher: Elsevier GmbH

    DOI： 10.1016/j.dza.2012.06.004 　

    ISSN： 0415-6412

  109. The Role of Oriental Medicine in the Great East Japan Earthquake Disaster

    高山真, 沖津玲奈, 岩崎鋼, 渡部正司, 神谷哲治, 平野篤, 松田綾音, 門馬靖武, 沼田健裕, 楠山寛子, 平田宗, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    日本東洋医学雑誌　62　(5)　621-626　2011/09

    Publisher: 日本東洋医学会

    DOI： 10.3937/kampomed.62.621 　

    ISSN： 0287-4857

    eISSN： 1882-756X

  110. The Role of Oriental Medicine in the Great East Japan Earthquake Disaster

    TAKAYAMA Shin, KUSUYAMA Hiroko, HIRATA Sou, KIKUCHI Akiko, SEKI Takashi, TAKEDA Takash, YAEGASHI Nobuo, OKITSU Reina, IWASAKI Koh, WATANABE Masashi, KAMIYA Tetsuharu, HIRANO Atsushi, MATSUDA Ayane, MONMA Yasutake, NUMATA Takehiro

    Kampo Medicine　62　(5)　621-626　2011/09

    Publisher: 一般社団法人 日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

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    The Great East Japan earthquake and tsunami disaster that occurred on March 11, 2011 seriously destroyed Japanese social activities the medical system included. We provided medical support to the damaged area, and mainly performed Oriental medicine. Traditional methods using physical diagnoses and the treatments with herbs, acupuncture, and massage were effective, where any infrastructure had suffered or any modern medical facilities had been destroyed. Acute phase infectious disease, common colds, and hypothermia were dominant. Allergies increased two weeks later, and there was much mental distress, and chronic pain symptoms one month later. We prescribed Kampo herbal medicines for common colds, hypothermia, allergies, and mental distress. Moreover, we also performed acupuncture and kneaded patients&#039; body to reduce pain, stiffness, and edema. These treatments were effective for both physical and mental distress. Thus we believe that Oriental medicine is valuable in disaster situations.

  111. 大建中湯投与,腹部温熱療法による上腸間膜動脈血流量の変化

    高山真, 沖津玲奈, 岩崎鋼, 渡部正司, 神谷哲治, 平野篤, 松田綾音, 沼田健裕, 楠山寛子, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    漢方と最新治療　20　(3)　253-258　2011/08

    Publisher:

  112. Short-term effects of acupuncture on open-angle glaucoma in retrobulbar circulation: additional therapy to standard medication. International-journal Peer-reviewed

    Shin Takayama, Takashi Seki, Toru Nakazawa, Naoko Aizawa, Seri Takahashi, Masashi Watanabe, Masayuki Izumi, Soichiro Kaneko, Tetsuharu Kamiya, Ayane Matsuda, Akiko Kikuchi, Tomoyuki Yambe, Makoto Yoshizawa, Shin-Ichi Nitta, Nobuo Yaegashi

    Evidence-based complementary and alternative medicine : eCAM　2011　157090-157090　2011

    DOI： 10.1155/2011/157090 　

    ISSN： 1741-427X

    eISSN： 1741-4288

  113. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer. International-journal Peer-reviewed

    Hiroyasu Yasuda, Mutsuo Yamaya, Katsutoshi Nakayama, Takahiko Sasaki, Satoru Ebihara, Akio Kanda, Masanori Asada, Daisuke Inoue, Tomoko Suzuki, Tatsuma Okazaki, Hidenori Takahashi, Motoki Yoshida, Tomohiro Kaneta, Kota Ishizawa, Shinsuke Yamanda, Naoki Tomita, Miyako Yamasaki, Akiko Kikuchi, Hiroshi Kubo, Hidetada Sasaki

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology　24　(4)　688-94　2006/02/01

    DOI： 10.1200/JCO.2005.04.0436 　

    ISSN： 0732-183X

    eISSN： 1527-7755

  114. γグロブリンの大量投与が奏功したC型慢性肝炎に合併したITP(immune thrombocytopenia)の1例

    林英守, 矢島義昭, 吉野章子, 青木千花, 佐藤真広, 高橋信孝, 宮崎敦史, 大平誠一, 遠藤一靖

    仙台市立病院医学雑誌　21　97-100　2001/05/25

    ISSN： 0388-8878

  115. 塩酸チクロピジン投与により発症した無か粒球症の1例

    林英守, 目々沢愛, 吉野章子, 佐々木徹, 山本匡, 高橋正樹, 秋保直樹, 山陰敬, 遠藤一靖

    仙台市立病院医学雑誌　21　113-115　2001/05/25

    ISSN： 0388-8878

  116. 血しょう交換療法が有効であった腎不全を合併した多発性骨髄腫の1例

    吉野章子, 秋保直樹, 山本匡, 高橋正樹, 遠藤文朗, 山陰敬, 杉山正春, 国分勝, 遠藤一靖

    仙台市立病院医学雑誌　20　(1)　85-89　2000/04/28

    ISSN： 0388-8878

  117. Case of aspirin intoxication where hemodialysis showed high efficacy.

    吉野章子, 秋保直樹, 山陰敬, 山本匡, 高橋正樹, 遠藤文朗, 杉山正春, 国分勝, 遠藤一靖

    仙台市立病院医学雑誌　19　(1)　77-80　1999/04/30

    ISSN： 0388-8878

  118. Case of Plasmodium vivax repeating recurrence.

    吉野章子, 大平誠一, 遠藤一靖, 長沼広, 大森智子, 伊妻壮晃, 石井元康

    仙台市立病院医学雑誌　19　(1)　71-75　1999/04/30

    ISSN： 0388-8878

Show all ︎Show first 5

Misc. 99

  1. COVID-19急性期症状、遷延症状への漢方薬治療に関する臨床研究の取り組みについて

    高山 真, 並木 隆雄, 三谷 和男, 久永 明人, 小田口 浩, 伊藤 隆, 有田 龍太郎, 小野 理恵, 齊藤 奈津美, 鈴木 聡子, 大澤 稔, 菊地 章子, 石井 正, 日本東洋医学会運営委員会特別ワーキンググループ

    和漢医薬学会学術大会要旨集　40回　37-37　2023/08

    Publisher: (一社)和漢医薬学会

  2. COVID-19軽症者等療養施設におけるモルヌピラビルの効果と安全性

    有田 龍太郎, 高山 真, 阿部 倫明, 菊地 章子, 大澤 稔, 小野寺 浩, 菅野 武, 齊藤 奈津美, 赤石 哲也, 小野 理恵, 只野 恭教, 鈴木 聡子, 菅原 章人, 石井 正

    日本プライマリ・ケア連合学会学術大会　14回　219-219　2023/05

    Publisher: (一社)日本プライマリ・ケア連合学会

  3. A review of frequently used Kampo prescriptions: Part 2-Hangekobokuto

    Suzuki Tomoko, Kikuchi Akiko, Kaneko Akiyo, Arita Ryutaro, Nogami Tatsuya, Saito Natsumi, Takayama Shin

    TRADITIONAL & KAMPO MEDICINE　2023/05

    DOI： 10.1002/tkm2.1373 　

    eISSN： 2053-4515

  4. 漢方医学の卒前臨床実習における体質チェックアンケートの内容と妥当性の検討

    神谷 哲治, 有田 龍太郎, 金子 聡一郎, 菊地 章子, 大澤 稔, 沼田 健裕, 齊藤 奈津美, 鈴木 聡子, 小野 理恵, 永田 真一, 高山 真, 石井 正

    医学教育　52　(Suppl.)　178-178　2021/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  5. 漢方による風邪対策

    菊地 章子

    日本東洋医学雑誌　71　(別冊)　128-128　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  6. 正常眼圧緑内障に対する当帰芍薬散の短期服用効果

    有田 龍太郎, 高山 真, 菊地 章子, 金子 聡一郎, 齊藤 奈津美, 石井 正

    日本東洋医学雑誌　71　(別冊)　148-148　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  7. 原因不明の肛門直腸痛に鍼治療が有効だった一例

    神谷 哲治, 小野 理恵, 菊地 章子, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　71　(別冊)　156-156　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  8. 黄連解毒湯と小柴胡湯が有効であったカルムスチン脳内留置用剤による難治性薬剤熱の一例

    鈴木 聡子, 高山 真, 有田 龍太郎, 菊地 章子, 石井 正

    日本東洋医学雑誌　71　(別冊)　188-188　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  9. 大学病院漢方内科の初診患者におけるうつ・不安スコアの検討

    菊地 章子, 小野 理恵, 永田 真一, 小島 三千代, 鈴木 聡子, 佐々木 浩代, 清水 雅行, 有田 龍太郎, 齊藤 奈津美, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　71　(別冊)　198-198　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  10. 慢性一次疼痛患者の漢方治療 単施設での後方視的検討

    小野 理恵, 高山 真, 菊地 章子, 有田 龍太郎, 齋藤 奈津美, 小島 三千代, 永田 真一, 鈴木 聡子, 清水 雅行, 沼田 健裕, 大澤 稔, 石井 正

    日本東洋医学雑誌　71　(別冊)　200-200　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  11. VRE保菌者に対するプロバイオティクスと補剤併用の試み

    河野 順子, 川村 強, 石川 理恵, 菊地 章子, 高山 真

    日本東洋医学雑誌　71　(別冊)　213-213　2021/07

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  12. 東北大学病院総合診療科におけるCOVID-19療養者往診の取り組み

    有田龍太郎, 高山真, 高山真, 小野理恵, 小野理恵, 菊地章子, 菊地章子, 大澤稔, 大澤稔, 齊藤奈津美, 齊藤奈津美, 鈴木聡子, 鈴木聡子, 小野寺保, 中村直毅, 稲葉洋平, 中山雅晴, 石井正, 石井正

    日本病院総合診療医学会雑誌(Web)　17　2021

    ISSN： 2185-8136

  13. COVID-19軽症者療養施設医療対応のための検査体制とその有用性

    高山真, 小野理恵, 有田龍太郎, 齊藤奈津美, 鈴木聡子, 只野恭教, 赤石哲也, 田中淳一, 菅野武, 菊地章子, 大澤稔, 小野寺浩, 阿部倫明, 井戸敬介, 稲葉洋平, 中村直毅, 中山雅晴, 石井正

    日本病院総合診療医学会雑誌(Web)　17　2021

    ISSN： 2185-8136

  14. デュロキセチン無効の一次性慢性疼痛に対する漢方治療

    小野 理恵, 菊地 章子, 岩岡 里佳, 大西 詠子, 山内 正憲, 高山 真

    日本ペインクリニック学会誌　27　(3)　O18-2　2020/10

    Publisher: (一社)日本ペインクリニック学会

    ISSN： 1340-4903

    eISSN： 1884-1791

  15. 人参養栄湯に関する文献レビューと考察

    高山 真, 有田 龍太郎, 大澤 稔, 菊地 章子, 沼田 健裕, 齊藤 奈津美, 西川 仁, 池野 由佳, 佐々木 浩代, 小島 三千代, 金子 聡一郎, 神谷 哲治, 清水 雅行, 石井 正

    日本東洋医学雑誌　70　(別冊)　159-159　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  16. 異なる弁証および漢方方剤で改善した、慢性疲労症候群自験症例2例についての考察

    佐々木 浩代, 沼田 健裕, 菊地 章子, 有田 龍太郎, 齊藤 奈津美, 小島 三千代, 西川 仁, 池野 由佳, 清水 雅行, 大澤 稔, 神谷 哲治, 金子 聡一郎, 高山 真, 石井 正

    日本東洋医学雑誌　70　(別冊)　160-160　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  17. 遷延する発熱に清心蓮子飲が奏功した2症例

    小島 三千代, 菊地 章子, 高山 真, 有田 龍太郎, 大澤 稔, 沼田 健裕, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 清水 雅行, 金子 聡一郎, 神谷 哲治, 石井 正

    日本東洋医学雑誌　70　(別冊)　175-175　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  18. 化学物質過敏症(MCS)に対する漢方治療の開発について

    大澤 稔, 高山 真, 菊地 章子, 沼田 健裕, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 小島 三千代, 清水 雅行, 金子 聡一郎, 神谷 哲治, 石井 正

    日本東洋医学雑誌　70　(別冊)　179-179　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  19. 登米市立上沼診療所における漢方薬使用状況の検討

    齊藤 奈津美, 沼田 健裕, 菊地 章子, 有田 龍太郎, 金子 聡一郎, 田中 淳一, 高山 真, 石井 正

    日本東洋医学雑誌　70　(別冊)　213-213　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  20. 漢方医と鍼灸師の病鍼連携をテーマに開催したシンポジウムの活動報告と意識調査

    神谷 哲治, 金子 聡一郎, 有田 龍太郎, 沼田 健裕, 菊地 章子, 大澤 稔, 齊藤 奈津美, 池野 由香, 小島 三千代, 佐々木 浩代, 西川 仁, 清水 雅行, 高山 真, 石井 正

    日本東洋医学雑誌　70　(別冊)　220-220　2019/06

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  21. 登米市立上沼診療所における漢方薬処方状況と傾向について

    齊藤奈津美, 佐々木直英, 沼田健裕, 沼田健裕, 菊地章子, 有田龍太郎, 金子聡一郎, 田中淳一, 阿部倫明, 高山真, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　10th (Web)　2019

  22. 腹診シミュレータを活用した漢方身体診察実習

    高山 真, 菊地 章子, 金子 聡一郎, 沼田 健裕, 有田 龍太郎, 大澤 稔, 神谷 哲治, 齊藤 奈津美, 池野 由佳, 西川 仁, 小島 三千代, 佐々木 浩代, 石井 正

    医学教育　49　(Suppl.)　148-148　2018/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  23. 腹診シミュレータを活用した漢方身体診察実習

    高山 真, 菊地 章子, 金子 聡一郎, 沼田 健裕, 有田 龍太郎, 大澤 稔, 神谷 哲治, 齊藤 奈津美, 池野 由佳, 西川 仁, 小島 三千代, 佐々木 浩代, 石井 正

    医学教育　49　(Suppl.)　148-148　2018/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  24. 上気道症状が半夏厚朴湯と麦門冬湯の併用で改善した2症例

    菊地 章子, 佐々木 浩代, 小島 三千代, 西川 仁, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 神谷 哲治, 金子 総一郎, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　69　(別冊)　268-268　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  25. 緑内障に対し漢方・鍼灸治療を行った症例の眼底血流の変化

    有田 龍太郎, 佐々木 浩代, 小島 三千代, 西川 仁, 齊藤 奈津美, 池野 由佳, 神谷 哲治, 金子 聡一郎, 沼田 健裕, 大澤 稔, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　69　(別冊)　269-269　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  26. 西洋医学的治療で難渋した交通事故多発外傷後の歯牙疼痛に鍼治療が有効だった一例

    神谷 哲治, 金子 聡一郎, 高山 真, 沼田 健裕, 菊地 章子, 大澤 稔, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 小島 三千代, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　294-294　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  27. 女性の慢性原発性頭痛患者における漢方薬の併用数はBMIと関係する

    大澤 稔, 高山 真, 菊地 章子, 沼田 健裕, 西川 仁, 齊藤 奈津美, 池野 由佳, 金子 聡一郎, 神谷 哲治, 有田 龍太郎, 小島 三千代, 佐々木 浩代, 田中 淳一, 原澤 健, 高橋 光生, 石井 正

    日本東洋医学雑誌　69　(別冊)　362-362　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  28. 医学生を対象とした鍼灸の認知度及び講義の影響に関するアンケート調査

    金子 聡一郎, 高山 真, 沼田 健裕, 菊地 章子, 有田 龍太郎, 池野 由佳, 西川 仁, 齊藤 奈津美, 神谷 哲治, 大澤 稔, 小島 三千代, 佐々木 浩代, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　382-382　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  29. 上気道症状が半夏厚朴湯と麦門冬湯の併用で改善した2症例

    菊地 章子, 佐々木 浩代, 小島 三千代, 西川 仁, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 神谷 哲治, 金子 総一郎, 沼田 健裕, 大澤 稔, 高山 真, 石井 正

    日本東洋医学雑誌　69　(別冊)　268-268　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  30. 緑内障に対し漢方・鍼灸治療を行った症例の眼底血流の変化

    有田 龍太郎, 佐々木 浩代, 小島 三千代, 西川 仁, 齊藤 奈津美, 池野 由佳, 神谷 哲治, 金子 聡一郎, 沼田 健裕, 大澤 稔, 菊地 章子, 高山 真, 石井 正

    日本東洋医学雑誌　69　(別冊)　269-269　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  31. 漢方薬に関し取り上げている診療ガイドラインの最近の動向

    高山 真, 有田 龍太郎, 齊藤 奈津美, 菊地 章子, 大澤 稔, 沼田 健裕, 西川 仁, 佐々木 浩代, 小島 三千代, 池野 由佳, 清崎 雅宣, 神谷 哲治, 金子 聡一郎, 奥田 拓史, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　282-282　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  32. 西洋医学的治療で難渋した交通事故多発外傷後の歯牙疼痛に鍼治療が有効だった一例

    神谷 哲治, 金子 聡一郎, 高山 真, 沼田 健裕, 菊地 章子, 大澤 稔, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 小島 三千代, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　294-294　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  33. 女性の慢性原発性頭痛患者における漢方薬の併用数はBMIと関係する

    大澤 稔, 高山 真, 菊地 章子, 沼田 健裕, 西川 仁, 齊藤 奈津美, 池野 由佳, 金子 聡一郎, 神谷 哲治, 有田 龍太郎, 小島 三千代, 佐々木 浩代, 田中 淳一, 原澤 健, 高橋 光生, 石井 正

    日本東洋医学雑誌　69　(別冊)　362-362　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  34. 医学生を対象とした鍼灸の認知度及び講義の影響に関するアンケート調査

    金子 聡一郎, 高山 真, 沼田 健裕, 菊地 章子, 有田 龍太郎, 池野 由佳, 西川 仁, 齊藤 奈津美, 神谷 哲治, 大澤 稔, 小島 三千代, 佐々木 浩代, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　382-382　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  35. 漢方薬に関し取り上げている診療ガイドラインの最近の動向

    高山 真, 有田 龍太郎, 齊藤 奈津美, 菊地 章子, 大澤 稔, 沼田 健裕, 西川 仁, 佐々木 浩代, 小島 三千代, 池野 由佳, 清崎 雅宣, 神谷 哲治, 金子 聡一郎, 奥田 拓史, 田中 淳一, 石井 正

    日本東洋医学雑誌　69　(別冊)　282-282　2018/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

  36. 漢方は災害時に役立つか?

    高山真, 沼田健裕, 菊地章子, 齊藤奈津美, 有田龍太郎, 田中淳一, 黒田仁, 阿部倫明, 石井正

    日本内科学会雑誌　107　(Suppl.)　258-258　2018/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  37. 原因不明の微熱・倦怠感に清心連子飲が奏効した1症例

    西川仁, 西川仁, 高山真, 菊地章子, 沼田健裕, 有田龍太郎, 大澤稔, 小島三千代, 金子聡一郎, 神谷哲治, 池野由佳, 齊藤奈津美, 佐々木浩代, 石井正

    日本東洋医学雑誌　69　2018

    ISSN： 0287-4857

  38. Acupuncture for Dysphasia

    Kikuchi Akiko, Kaneko Soichiro, Takayama Shin

    The Japanese Journal of Rehabilitation Medicine　55　(12)　978-983　2018

    Publisher: The Japanese Association of Rehabilitation Medicine

    ISSN： 1881-3526

    More details Close

    &lt;p&gt;嚥下障害に対する鍼灸治療に関して，海外では有効性を示した研究報告が数々報告されている．鍼灸治療は基本的に患者の状態に応じて治療法を選択するオーダーメイド医療であるため治療の標準化は難しい．本邦では主に太渓と足三里という下肢の経穴に刺激を加えることで嚥下反射が改善するという研究が報告されている．一般の医療・介護施設で通常の鍼灸治療を行うことはさまざまな面で困難を伴うが，簡便に用いることのできる円皮鍼が有用となる可能性がある．鍼灸治療の作用機序はいまだ十分に解明されておらず，鍼灸が嚥下障害に対する治療法の選択肢として広く認識されるには，今後さらに研究を進め，臨床経験を蓄積することが必要である．&lt;/p&gt;

  39. 東北大学における地域総合診療医育成寄附講座の設置

    石井正, 小野寺浩, 阿部倫明, 高山真, 金子聡一郎, 田中淳一, 黒田仁, 菊地章子, 有田龍太郎, 齊藤奈津美, 奥田拓史

    日本プライマリ・ケア連合学会学術大会抄録集　9th　402　2018

  40. 東北大学病院総合診療科を受診し漢方治療を行った症例の特徴と経過

    高山真, 野崎裕之, 阿部倫明, 鈴木聡子, 奥田拓史, 有田龍太郎, 齊藤奈津美, 田中淳一, 沼田健裕, 菊地章子, 大澤稔, 黒田仁, 阿部倫明, 奈良正之, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　9th　307　2018

  41. 低血圧症における漢方治療のエビデンス (特集 循環器疾患における漢方治療のエビデンス)

    高山 真, 菊地 章子

    日本医事新報　(4875)　34-39　2017/09/30

    Publisher: 日本医事新報社

    ISSN： 0385-9215

  42. 東北大学における参加型漢方実習の工夫とアンケートによる評価

    高山 真, 沼田 健裕, 菊地 章子, 金子 聡一郎, 有田 龍太郎, 大澤 稔, 神谷 哲治, 齊藤 奈津美, 池野 由佳, 西川 仁, 小島 三千代, 石井 正

    医学教育　48　(Suppl.)　99-99　2017/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  43. 東北大学医学部医学科1年次の東日本大震災被災地見学実習の経過報告 宮城コースと浪江コースとの比較

    阿部 倫明, 田中 淳一, 菊地 章子, 沼田 健裕, 黒田 仁, 高山 真, 石井 誠一, 加賀谷 豊, 石井 正

    医学教育　48　(Suppl.)　123-123　2017/08

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  44. 身体的訴えにより学校生活に支障を来した小児に対する漢方薬治療の効果の検討

    小島三千代, 小島三千代, 菊地章子, 高山真, 有田龍太郎, 金子聡一郎, 齊藤奈津美, 神谷哲治, 池野由佳, 西川仁, 佐々木浩代, 大澤稔, 沼田健裕, 石井正

    日本東洋医学雑誌　68　(別冊)　401-401　2017/04/28

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  45. 漢方治療により高齢者の多剤処方の減薬が可能となった一例

    池野 由佳, 菊地 章子, 沼田 健裕, 有田 龍太郎, 大澤 稔, 齊藤 奈津美, 西川 仁, 小島 三千代, 佐々木 浩代, 金子 聡一郎, 神谷 哲治, 田中 淳一, 山下 和良, 高山 真, 石井 正

    日本東洋医学雑誌　68　(別冊)　341-341　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  46. 四肢の冷えと片頭痛を伴った緑内障患者に対する当帰芍薬散の効果

    菊地 章子, 高山 真, 有田 龍太郎, 金子 聡一郎, 齊藤 奈津美, 神谷 哲治, 池野 由佳, 西川 仁, 小島 三千代, 佐々木 浩代, 大澤 稔, 沼田 健裕, 石井 正

    日本東洋医学雑誌　68　(別冊)　369-369　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  47. 葛根湯が無効な肩凝りに対する漢方治療 肩凝り部位に応じた併用薬の選択について

    大澤 稔, 高山 真, 菊地 章子, 沼田 健裕, 池野 由佳, 西川 仁, 齊藤 奈津美, 金子 聡一郎, 神谷 哲治, 有田 龍太郎, 小島 三千代, 佐々木 浩代, 原澤 健, 高橋 光生, 石井 正

    日本東洋医学雑誌　68　(別冊)　371-371　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  48. 東北大学医学部における漢方の臨床実習に対するアンケート調査

    沼田健裕, 有田龍太郎, 高山真, 菊地章子, 金子聡一郎, 神谷哲治, 齊藤奈津美, 池野由佳, 西川仁, 大澤稔, 小島三千代, 佐々木浩代, 田中淳一, 山下和良, 石井正

    日本東洋医学雑誌　68　(別冊)　380-380　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  49. 東北大学医学部5年次学生を対象とした鍼灸実習に対するアンケート調査

    金子聡一郎, 高山真, 沼田健裕, 菊地章子, 池野由佳, 西川仁, 小島三千代, 有田龍太郎, 大澤稔, 佐々木浩代, 神谷哲治, 齊藤奈津美, 田中淳一, 山下和良, 石井正

    日本東洋医学雑誌　68　(別冊)　381-381　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  50. カードゲームを用いた漢方教育ツールの開発とその教育効果の検討

    神谷哲治, 神谷哲治, 金子聡一郎, 有田龍太郎, 沼田健裕, 高山真, 菊地章子, 齊藤奈津美, 大澤稔, 佐々木浩代, 池野由佳, 西川仁, 小島三千代, 田中淳一, 山下和良, 石井正

    日本東洋医学雑誌　68　(別冊)　383-383　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  51. 初期研修医に対する漢方医学教育(アンケート調査から考える)

    高山真, 小林誠一, 鈴木恵綾, 石川敬一, 佐藤慎哉, 齊藤奈津美, 有田龍太郎, 金子聡一郎, 神谷哲治, 小島三千代, 佐々木浩代, 西川仁, 池野由佳, 沼田健裕, 大澤稔, 菊地章子, 山下和良, 石井正

    日本東洋医学雑誌　68　(別冊)　256-256　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  52. 近世・現代の比較から漢方の明日を考える 古典とエビデンス

    高山真, 齊藤奈津美, 有田龍太郎, 金子聡一郎, 神谷哲治, 小島三千代, 佐々木浩代, 西川仁, 池野由佳, 沼田健裕, 大澤稔, 菊地章子, 山下和良, 石井正

    日本東洋医学雑誌　68　(別冊)　110-110　2017/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  53. 大建中湯を用いた神経変性疾患患者の機能性便秘に対するランダム化比較試験

    有田龍太郎, 沼田健裕, 齊藤奈津美, 菊地章子, 高山真, 飛田宗重, 石井正

    日本内科学会雑誌　106　(Suppl.)　184-184　2017/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  54. 耳鼻咽喉科的症状に対する漢方薬治療例の検討

    西川仁, 西川仁, 高山真, 菊地章子, 沼田健裕, 池野由佳, 金子聡一郎, 神谷哲治, 有田龍太郎, 齊藤奈津美, 大澤稔, 小島三千代, 佐々木浩代, 石井正

    日本東洋医学雑誌　68　2017

    ISSN： 0287-4857

  55. 高血圧患者における腎動脈エコーによる腎内血流評価の7年間の推移について

    菅原香織, 阿部倫明, 阿部倫明, 三木俊, 庄子睦美, 鎌田真希, 三木未佳, 齊藤奈津美, 有田龍太郎, 沼田健裕, 田中淳一, 菊地章子, 黒田仁, 高山真, 菅原明, 石井正

    日本高血圧学会総会プログラム・抄録集　39回　321-321　2016/09

    Publisher: (NPO)日本高血圧学会

  56. 大災害時の漢方治療~その導入時期や活用方法,注意点などについて~

    高山真, 齊藤奈津美, 有田龍太郎, 渡邉秀和, 西川仁, 池野由佳, 大澤稔, 菊地章子, 沼田健裕

    和漢医薬学会学術大会要旨集　33回　53-53　2016/08

    Publisher: (一社)和漢医薬学会

  57. 急性期・重症入院患者への漢方治療 現代医療の最前線に漢方を 大災害時の漢方治療 その導入時期や活用方法、注意点などについて

    高山 真, 齊藤 奈津美, 有田 龍太郎, 渡邉 秀和, 西川 仁, 池野 由佳, 大澤 稔, 菊地 章子, 沼田 健裕

    和漢医薬学会学術大会要旨集　33回　53-53　2016/08

    Publisher: (一社)和漢医薬学会

  58. 東北の2大学病院,2臨床研修指定病院における初期研修医の漢方教育に対する意向調査

    高山真, 小林誠一, 石橋悟, 齊藤奈津美, 沼田健裕, 菊地章子, 石川敬一, 大澤稔, 有田龍太郎, 田中淳一, 黒田仁, 阿部倫明, 田畑雅央, 佐藤慎哉, 石井正

    医学教育　47　(Suppl.)　135-135　2016/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  59. 知っていると便利な漢方薬,安全に効果的に使うには?

    高山真, 齊藤奈津美, 有田龍太郎, 沼田健裕, 菊地章子, 大澤稔, 池野由佳, 西川仁, 渡邉秀和, 田中淳一, 黒田仁, 阿部倫明, 石井正, 石井正

    日本小児救急医学会雑誌　15　(2)　154-154　2016/06

    Publisher: (一社)日本小児救急医学会

    ISSN： 1346-8162

  60. 1型糖尿病患者の慢性乾性咳嗽に対し漢方治療が有効であった一例

    池野由佳, 沼田健裕, 高山真, 菊地章子, 齊藤奈津美, 西川仁, 金子聡一郎, 神谷哲治, 田中淳一, 石井正

    日本東洋医学雑誌　67　(別冊)　376-376　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  61. 健常者に対するYNSA治療点の部位特異性と有効性の検討

    神谷哲治, 金子聡一郎, 沼田健裕, 池野由佳, 菊地章子, 齊藤奈津美, 田中淳一, 高山真, 石井正

    日本東洋医学雑誌　67　(別冊)　362-362　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  62. 反復性微熱を伴う慢性疲労症候群を少陽病と診断し小柴胡湯加減が奏効した10代女子の2症例

    沼田健裕, 高山真, 菊地章子, 池野由佳, 西川仁, 金子聡一郎, 神谷哲治, 齊藤奈津美, 田中淳一, 石井正

    日本東洋医学雑誌　67　(別冊)　359-359　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  63. 腹診シミュレータを用いた漢方医学教育法―教育・学習スタイルの異なる二回のセッションから―

    齊藤奈津美, 高山真, 金子総一郎, 沼田健裕, 池野由佳, 菊地章子, 西川仁, 神谷哲治, 田中淳一, 石井正

    日本東洋医学雑誌　67　(別冊)　292-292　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  64. 医学教育における漢方 東洋医学を次世代にどのように伝えるか 医学生の授業における問題解決過程を学会発表・論文作成まで展開させる漢方の学術的支援

    高山 真, 沼田 健裕, 金子 聡一郎, 神谷 哲治, 田中 淳一, 池野 由佳, 西川 仁, 齊藤 奈津美, 菊地 章子, 大澤 稔, 有田 龍太郎, 黒田 仁, 松向寺 孝臣, 阿部 倫明, 石井 正

    日本東洋医学雑誌　67　(別冊)　182-182　2016/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  65. 臨床を想定した漢方薬処方のシミュレーション教育

    齊藤奈津美, 高山真, 沼田健裕, 菊地章子, 田中淳一, 黒田仁, 阿部倫明, 石井正

    日本内科学会雑誌　105　(Suppl.)　275-275　2016/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  66. 鍼灸をおもな題材とした統合医療セミナーの取り組み

    沼田健裕, 沼田健裕, 金子聡一郎, 金子聡一郎, 神谷哲治, 神谷哲治, 高山真, 高山真, 田中淳一, 池野由佳, 池野由佳, 西川仁, 西川仁, 齊藤奈津美, 齊藤奈津美, 菊地章子, 菊地章子, 阿部倫明, 黒田仁, 松向寺孝臣, 石井正, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　7th　274　2016

  67. 初期研修医の漢方教育に対する意識調査,東北大学病院と石巻赤十字病院の比較

    高山真, 小林誠一, 石橋悟, 齊藤奈津美, 沼田健裕, 菊地章子, 田中淳一, 黒田仁, 田畑雅央, 阿部倫明, 石井正

    日本プライマリ・ケア連合学会学術大会抄録集　7th　336　2016

  68. 大学病院における初期研修医の漢方医学教育に対する意識調査

    高山真, 高山真, 田畑雅央, 小林誠一, 石橋悟, 沼田健裕, 池野由佳, 齊藤奈津美, 菊地章子, 田中淳一, 松向寺孝臣, 黒田仁, 阿部倫明, 金村政輝, 加賀谷豊, 石井正

    医学教育　46　(Suppl.)　178-178　2015/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  69. 腹診シミュレータを用いた漢方医学教育の試み

    富樫尭史, 高山真, 高山真, 沼田健裕, 池野由佳, 金子聡一郎, 神谷哲治, 齊藤奈津美, 菊地章子, 田中淳一, 松向寺孝臣, 黒田仁, 阿部倫明, 加賀谷豊, 石井正, 張替秀郎

    医学教育　46　(Suppl.)　242-242　2015/07

    Publisher: (一社)日本医学教育学会

    ISSN： 0386-9644

  70. 補剤系漢方薬や抗うつ剤が奏効せず抗炎症系漢方薬が奏効した慢性疲労症候群の2症例

    沼田 健裕, 高山 真, 池野 由佳, 菊地 章子, 金子 聡一郎, 神谷 哲治, 齊藤 奈津美, 神 久和, 金村 政輝, 阿部 倫明, 松向寺 孝臣, 黒田 仁, 田中 淳一, 石井 正

    日本疲労学会誌　11　(1)　61-61　2015/05

    Publisher: 日本疲労学会

  71. 補剤系漢方薬や抗うつ剤が奏効せず抗炎症系漢方薬が奏効した慢性疲労症候群の2症例

    沼田健裕, 高山真, 池野由佳, 菊地章子, 金子聡一郎, 神谷哲治, 齊藤奈津美, 神久和, 金村政輝, 阿部倫明, 松向寺孝臣, 黒田仁, 田中淳一, 石井正

    日本疲労学会誌　11　(1)　99-99　2015/05

    Publisher: 日本疲労学会

  72. 多系統萎縮症のふらつきに鍼治療が有効だった一例

    神谷哲治, 高山真, 金子聡一郎, 沼田健裕, 池野由佳, 菊地章子, 田中淳一, 石井正

    日本東洋医学雑誌　66　(別冊)　285-285　2015/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  73. 超音波診断装置による測定時の呼吸調節が自律神経活動へ与える影響の検討

    金子聡一郎, 金子聡一郎, 渡部正司, 高山真, 高山真, 沼田健裕, 池野由佳, 神谷哲治, 神谷哲治, 菊地章子, 田中淳一, 八重樫伸生, 石井正

    日本東洋医学雑誌　66　(別冊)　286-286　2015/04

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  74. 円皮鍼を用いた高齢者の誤嚥性肺炎予防に関する研究

    菊地 章子, 関 隆志, 高山 真, 沼田 健裕, 田中 淳一, 黒田 仁, 松向寺 孝臣, 金村 政輝, 阿部 倫明, 石井 正

    日本内科学会雑誌　104　(Suppl.)　169-169　2015/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  75. 重症心身障害者における誤嚥性肺炎予防に漢方が奏効した3症例,VFによる検討

    高橋里実, 岩崎鋼, 高山真, 菊地章子, 関隆志, 八重樫伸生

    日本東洋医学雑誌　63　193　2012/05/01

    ISSN： 0287-4857

  76. 災害時における東洋医学による医療活動

    高山真, 沖津玲奈, 岩崎鋼, 渡部正司, 神谷哲治, 平野篤, 松田綾音, 門馬靖武, 沼田健裕, 楠山寛子, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    日本東洋医学雑誌　63　(別冊)　99-99　2012/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  77. 下腿への鍼刺激による上腕動脈の血行動態の検討

    渡部正司, 高山真, 関隆志, 沼田健裕, 楠山寛子, 神谷哲治, 松田綾音, 岩崎鋼, 菊地章子, 武田卓, 八重樫伸生

    日本東洋医学雑誌　63　(別冊)　284-284　2012/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  78. 開放隅角緑内障の眼球後血流,眼圧に対する鍼治療の効果

    高山真, 渡部正司, 神谷哲治, 松田綾音, 楠山寛子, 沼田健裕, 岩崎鋼, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    日本東洋医学雑誌　63　(別冊)　343-343　2012/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  79. 大建中湯内服および腹部温熱刺激による上腸間膜動脈血流量の変化

    高山 真, 関 隆志, 沖津 玲奈, 菊地 章子, 岩崎 鋼, 武田 卓, 八重樫 伸生

    日本内科学会雑誌　101　(Suppl.)　342-342　2012/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  80. 東日本大震災後に被災地で行なった漢方診療の報告

    高山真, 岩崎鋼, 沖津玲奈, 沼田健裕, 菊地章子, 関隆志, 武田卓, 八重樫伸生

    日本内科学会雑誌　101　(Suppl.)　220-220　2012/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  81. 異なる経穴および非経穴への鍼刺激における上腕動脈血流量の比較検討

    渡部正司, 高山真, 関隆志, 沖津玲奈, 神谷哲治, 菊地章子, 岩崎鋼, 武田卓, 八重樫伸生

    日本東洋医学雑誌　62　(別冊)　270-270　2011/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  82. 大建中湯投与,腹部温熱療法による上腸間膜動脈血流量の変化

    高山真, 渡部正司, 関隆志, 神谷哲治, 松田綾音, 沖津玲奈, 菊地章子, 岩崎鋼, 武田卓, 八重樫伸生

    日本東洋医学雑誌　62　(別冊)　243-243　2011/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  83. 大建中湯内服および腹部温熱刺激による上腸間膜動脈血流量の変化

    高山真, 関隆志, 沖津玲奈, 菊地章子, 岩崎鋼, 武田卓, 八重樫伸生

    日本内科学会雑誌　100　(Suppl.)　161-161　2011/02

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  84. 094 重症筋無力症患者の鍼灸治療(神経・筋疾患2,一般演題,伝統医学のあるべきかたちとは-世界の潮流と日本の役割-,第59回日本東洋医学会学術総会)

    関隆志, 金子聡一郎, 神谷哲治, 松田綾音, 千葉勝, 沖津玲奈, 高山真, 菊地章子, 岩崎鋼, 古川勝敏, 佐々木英忠, 荒井啓行

    日本東洋醫學雜誌　59　2008/05/07

    Publisher: 社団法人日本東洋医学会

    ISSN： 0287-4857

  85. 重症筋無力症患者の鍼灸治療

    関隆志, 金子聡一郎, 神谷哲治, 松田綾音, 千葉勝, 沖津玲奈, 高山真, 菊地章子, 岩崎鋼, 古川勝敏, 佐々木英忠, 荒井啓行

    日本東洋医学雑誌　59　(別冊)　174-174　2008/05

    Publisher: (一社)日本東洋医学会

    ISSN： 0287-4857

    eISSN： 1882-756X

  86. 誤嚥性肺炎 誤嚥性肺炎の診断

    山谷睦雄, 海老原孝枝, 菊地章子, 山崎都, 安田浩康, 吉田元樹, 矢満田慎介, 関隆志, 中山勝敏, 久保裕司

    月刊呼吸器科　10　(3)　179-185　2006/09/28

    Publisher: (有)科学評論社

    ISSN： 1347-0051

  87. 日本人男性における肺機能低下に対するHO‐1遺伝子多型の関与

    菊地章子, 中山勝敏, 安田浩康, 佐々木陽彦, 吉田元樹, 鈴木朋子, 山谷睦雄

    日本呼吸器学会雑誌　44　267　2006/06/10

    ISSN： 1343-3490

  88. 既喫煙者の肺機能低下に及ぼすヘムオキシゲナーゼ―1遺伝子多型性の影響

    山谷睦雄, 中山勝敏, 菊地章子, 海老原覚, 安田浩康

    日本老年医学会雑誌　43　58　2006/05/07

    ISSN： 0300-9173

  89. 難治性呼吸器疾患 病態解明と治療の最前線 誤えん性呼吸器疾患

    山谷睦雄, 大類孝, 海老原孝枝, 菊地章子, 安田浩康, 中山勝敏, 久保裕司

    モダンフィジシャン　26　(3)　414-418　2006/03/15

    Publisher: (株)新興医学出版社

    ISSN： 0913-7963

  90. Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism

    Yasuda H., Okinaga S., Yamaya M., Ohrui T., Higuchi M., Shinkawa M., Itabashi S., Nakayama K., Asada M., Kikuchi A., Shibahara S., Sasaki H.

    Journal of Medical Genetics　43　(4)　e17　2006

    Publisher: BMJ Publishing Group

    DOI： 10.1136/jmg.2005.035824 　

    ISSN： 0022-2593

  91. 肺腺癌発症におけるヘムオキシゲナーゼ‐1遺伝子多型性の関与

    久保裕司, 山谷睦雄, 菊地章子, 安田浩康, 鈴木聡, 半田政志, 佐々木英忠

    日本老年医学会雑誌　41　(4)　442-443　2004/07/25

    ISSN： 0300-9173

  92. 肺腺癌発症におけるヘムオキシゲナーゼ‐1遺伝子多型性の関与

    山谷睦雄, 菊地章子, 安田浩康, 久保裕司, 佐々木英忠

    日本老年医学会雑誌　41　135　2004/05/17

    ISSN： 0300-9173

  93. 肺腺癌発症におけるヘムオキシゲナーゼ-1遺伝子多型性の関与 (日本呼吸器学会雑誌)

    菊地章子, 山谷睦雄, 安田浩康, 久保裕司, 鈴木聡, 半田政志, 佐々木英忠

    日本呼吸器学会雑誌　42　(増刊)　243-243　2004/03

  94. 呼吸器におけるレドックス制御 ヘムオキシゲナーゼ‐1と肺気腫症の感受性

    山谷睦雄, 菊地章子, 佐々木英忠, 海老原覚, 平井弥夫, 柴原茂樹, 安田浩康, 関沢清久

    Lung Perspect　10　(4)　414-418　2002/10/01

    ISSN： 0919-5742

  95. Rockwool fiber workerにみられた肺線維症

    山谷睦雄, 中山勝敏, 菊地章子, 安田浩康, 佐々木英忠

    分子呼吸器病　6　(2)　178-180　2002/03/01

    ISSN： 1342-436X

  96. 分子呼吸器病ARCHIVES PART 1 気道上皮細胞 ウイルス感染

    山谷睦雄, 鈴木朋子, 菊地章子, 安田浩康, 佐々木英忠

    分子呼吸器病　5　(6)　491-494　2001/11/01

    ISSN： 1342-436X

  97. 【Molecular Biologyを基礎にした呼吸器疾患の理解:2001/2002 Update】 呼吸器炎症疾患の分子医学 肺気腫症とheme oxygenase

    山谷 睦雄, 冲永 壮治, 山田 紀広, 中山 勝敏, 安田 浩康, 菊地 章子, 海老原 覚, 佐々木 英忠, 柴原 茂樹, 関沢 清久

    日本胸部臨床　60　(増刊)　S76-S80　2001/11

    Publisher: 克誠堂出版(株)

    ISSN： 0385-3667

    More details Close

    喫煙は慢性肺気腫の主要なリスクファクターであるが,喫煙者の一部に慢性肺気腫が発症することより,喫煙に対する感受性の違いが示唆されていた.喫煙のオキシダントに対する抵抗性が肺気腫で低下しているかどうかを調べるため,抗オキシダント作用を持つヘムオキシゲナーゼの発現を抑制するGT反復の遺伝子多型を比較した.慢性肺気腫ではGT反復配列数の長い割合が非肺気腫喫煙者に比べて高い結果が得られた.慢性肺気腫ではGT反復によるヘムオキシゲナーゼの誘導抑制が強く,喫煙中のオキシダントに対する防御能力が弱いために発症する可能性が考えられた

  98. 薬物療法 シロスタゾールによる老人性肺炎予防

    山谷睦雄, 矢内勝, 大類孝, 松井敏史, 鈴木朋子, 石塚聡, 吉野章子, 丸山将浩, 佐々木英忠

    呼吸　20　(6)　603-606　2001/06

    Publisher: (一社)呼吸研究

    ISSN： 0286-9314

  99. 33)房室結節リエントリー性頻拍に対する遅伝導領域のアブレーションで房室接合部の速伝導路の伝導障害を来した1例

    吉野 章子, 八木 哲夫, 小田倉 弘典, 滑川 明男, 大友 淳, 石田 明彦, 菅井 義尚, 伊藤 明一

    Japanese circulation journal　63　(2)　699-699　1999/08/20

    Publisher: 社団法人日本循環器学会

    ISSN： 0047-1828

Show all ︎Show first 5

Books and Other Publications 1

  1. 論より証拠の漢方処方

    高山, 真

    日本医事新報社　2018/04

    ISBN: 9784784947607

Presentations 21

  1. 漢方医と鍼灸師の病鍼連携をテーマに開催したシンポジウムの活動報告と意識調査

    神谷 哲治, 金子 聡一郎, 有田 龍太郎, 沼田 健裕, 菊地 章子, 大澤 稔, 齊藤 奈津美, 池野 由香, 小島 三千代, 佐々木 浩代, 西川 仁, 清水 雅行, 高山 真, 石井 正

    日本東洋医学雑誌　2019/06

  2. 登米市立上沼診療所における漢方薬使用状況の検討

    齊藤 奈津美, 沼田 健裕, 菊地 章子, 有田 龍太郎, 金子 聡一郎, 田中 淳一, 高山 真, 石井 正

    日本東洋医学雑誌　2019/06

  3. 化学物質過敏症(MCS)に対する漢方治療の開発について

    大澤 稔, 高山 真, 菊地 章子, 沼田 健裕, 有田 龍太郎, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 小島 三千代, 清水 雅行, 金子 聡一郎, 神谷 哲治, 石井 正

    日本東洋医学雑誌　2019/06

  4. 遷延する発熱に清心蓮子飲が奏功した2症例

    小島 三千代, 菊地 章子, 高山 真, 有田 龍太郎, 大澤 稔, 沼田 健裕, 齊藤 奈津美, 池野 由佳, 西川 仁, 佐々木 浩代, 清水 雅行, 金子 聡一郎, 神谷 哲治, 石井 正

    日本東洋医学雑誌　2019/06

  5. 人参養栄湯に関する文献レビューと考察

    高山 真, 有田 龍太郎, 大澤 稔, 菊地 章子, 沼田 健裕, 齊藤 奈津美, 西川 仁, 池野 由佳, 佐々木 浩代, 小島 三千代, 金子 聡一郎, 神谷 哲治, 清水 雅行, 石井 正

    日本東洋医学雑誌　2019/06

  6. 異なる弁証および漢方方剤で改善した、慢性疲労症候群自験症例2例についての考察

    佐々木 浩代, 沼田 健裕, 菊地 章子, 有田 龍太郎, 齊藤 奈津美, 小島 三千代, 西川 仁, 池野 由佳, 清水 雅行, 大澤 稔, 神谷 哲治, 金子 聡一郎, 高山 真, 石井 正

    日本東洋医学雑誌　2019/06

  7. 医学生を対象とした鍼灸の認知度及び講義の影響に関するアンケート調査

    金子 聡一郎, 高山 真, 沼田 健裕, 菊地 章子, 有田 龍太郎, 池野 由佳, 西川 仁, 齊藤 奈津美, 神谷 哲治, 大澤 稔, 小島 三千代, 佐々木 浩代, 田中 淳一, 石井 正

    日本東洋医学雑誌　2018/05

  8. 西洋医学的治療で難渋した交通事故多発外傷後の歯牙疼痛に鍼治療が有効だった一例

    神谷哲治, 神谷哲治, 神谷哲治, 金子聡一郎, 高山真, 高山真, 沼田健裕, 沼田健裕, 菊地章子, 菊地章子, 大澤稔, 大澤稔, 有田龍太郎, 齊藤奈津美, 池野由佳, 西川仁, 佐々木浩代, 小島三千代, 田中淳一, 石井正, 石井正

    日本東洋医学雑誌　2018/05/01

  9. 漢方薬に関し取り上げている診療ガイドラインの最近の動向

    高山真, 有田龍太郎, 齊藤奈津美, 菊地章子, 大澤稔, 沼田健裕, 西川仁, 佐々木浩代, 小島三千代, 池野由佳, 清崎雅宣, 神谷哲治, 金子聡一郎, 奥田拓史, 田中淳一, 石井正

    日本東洋医学雑誌　2018/05/01

  10. 緑内障に対し漢方・鍼灸治療を行った症例の眼底血流の変化

    有田龍太郎, 佐々木浩代, 小島三千代, 西川仁, 齊藤奈津美, 池野由佳, 神谷哲治, 金子聡一郎, 沼田健裕, 大澤稔, 菊地章子, 高山真, 石井正

    日本東洋医学雑誌　2018/05/01

  11. 上気道症状が半夏厚朴湯と麦門冬湯の併用で改善した2症例

    菊地章子, 佐々木浩代, 小島三千代, 西川仁, 有田龍太郎, 齊藤奈津美, 池野由佳, 神谷哲治, 金子総一郎, 沼田健裕, 大澤稔, 高山真, 石井正

    日本東洋医学雑誌　2018/05/01

  12. 原因不明の微熱・倦怠感に清心連子飲が奏効した1症例

    西川仁, 西川仁, 高山真, 菊地章子, 沼田健裕, 有田龍太郎, 大澤稔, 小島三千代, 金子聡一郎, 神谷哲治, 池野由佳, 齊藤奈津美, 佐々木浩代, 石井正

    日本東洋医学雑誌　2018/05/01

  13. 女性の慢性原発性頭痛患者における漢方薬の併用数はBMIと関係する

    大澤稔, 高山真, 菊地章子, 沼田健裕, 西川仁, 齊藤奈津美, 池野由佳, 金子聡一郎, 神谷哲治, 有田龍太郎, 小島三千代, 佐々木浩代, 田中淳一, 原澤健, 高橋光生, 石井正

    日本東洋医学雑誌　2018/05/01

  14. 漢方治療により高齢者の多剤処方の減薬が可能となった一例

    池野由佳, 池野由佳, 菊地章子, 沼田健裕, 有田龍太郎, 大澤稔, 齊藤奈津美, 西川仁, 小島三千代, 佐々木浩代, 金子聡一郎, 神谷哲治, 田中淳一, 山下和良, 高山真, 石井正

    日本東洋医学雑誌　2017/04/28

  15. 葛根湯が無効な肩凝りに対する漢方治療~肩凝り部位に応じた併用薬の選択について~

    大澤稔, 高山真, 菊地章子, 沼田健裕, 池野由佳, 西川仁, 齊藤奈津美, 金子聡一郎, 神谷哲治, 有田龍太郎, 小島三千代, 佐々木浩代, 原澤健, 高橋光生, 石井正

    日本東洋医学雑誌　2017/04/28

  16. 耳鼻咽喉科的症状に対する漢方薬治療例の検討

    西川仁, 西川仁, 高山真, 菊地章子, 沼田健裕, 池野由佳, 金子聡一郎, 神谷哲治, 有田龍太郎, 齊藤奈津美, 大澤稔, 小島三千代, 佐々木浩代, 石井正

    日本東洋医学雑誌　2017/04/28

  17. 四肢の冷えと片頭痛を伴った緑内障患者に対する当帰芍薬散の効果

    菊地章子, 高山真, 有田龍太郎, 金子聡一郎, 齊藤奈津美, 神谷哲治, 池野由佳, 西川仁, 小島三千代, 佐々木浩代, 大澤稔, 沼田健裕, 石井正

    日本東洋医学雑誌　2017/04/28

  18. 円皮鍼を用いた高齢者の誤嚥性肺炎予防に関する研究

    菊地章子, 関隆志, 高山真, 沼田健裕, 田中淳一, 黒田仁, 松向寺孝臣, 金村政輝, 阿部倫明, 石井正

    日本内科学会雑誌　2015/02/20

  19. 肺腺癌発症におけるヘムオキシゲナーゼー1遺伝子多型性の関与

    菊地章子, 山谷睦雄, 安田浩康, 久保裕司, 鈴木聡, 半田政志, 佐々木英忠

    日本呼吸器学会雑誌　2004/03/10

  20. 炎症性肺疾患における動脈血一酸化炭素ヘモグロビン濃度(CO‐Hb)の検討

    安田浩康, 山谷睦雄, 中山勝敏, 門馬瑞枝, 吉野章子, 座安清, 佐々木英忠

    日本呼吸器学会雑誌　2001/03/10

  21. 33)房室結節リエントリー性頻拍に対する遅伝導領域のアブレーションで房室接合部の速伝導路の伝導障害を来した1例

    吉野 章子, 八木 哲夫, 小田倉 弘典, 滑川 明男, 大友 淳, 石田 明彦, 菅井 義尚, 伊藤 明一

    Japanese circulation journal　1999/08/20

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Research Projects 10

  1. 呼吸器ウイルス感染症における重症化抑制に関する研究

    菊地 章子, 山谷 睦雄, 児玉 栄一, 高山 真, 西村 秀一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2028/03/31

  2. 講義と実習を連動させた効果的な漢方教育プログラムの開発と教育効果の検証

    高山 真, 菊地 章子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2019/04/01 - 2024/03/31

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    目的と計画：医学教育モデル・コア・カリキュラム（コアカリ）、医学教育分野別評価基準日本版、International Classification of Diseases 11th Revisionの動向を背景に、コアカリに準じた一般目標および到達目標を実現するために①ミニマムスタンダードの講義を実践、②hands on 漢方実習を実践、③漢方臨床推論を講義内で実践、④診療参加型漢方実習を実践、以上を行い、その教育効果を明らかにする。さらに、各大学の漢方教育に参考となるようこれらの実践内容を汎用性のあるものに改定し公開する。 実績：2022年度は上記①～④を行い、得られたデータをもとに、「アクティブラーニングの実践により漢方医学知識が向上し、学術活動経験により探究心が涵養される」ことを医学教育学会で発表し、論文として日本東洋医学雑誌に掲載となった。また、②に関連しhands on実習の中で行った「鍼灸による学生の理解度の変化」を全日本鍼灸学会で発表した。さらに、漢方医学教育の「卒前カリキュラムの標準化」のため、日本漢方医学教育協議会（全国82大学医学部漢方教育担当者で構成）作成した基盤カリキュラムとモデルスライドと講義ガイドを論文化し公開された。これをもとに第71回日本東洋医学会学術総会で行った、「漢方共通模擬講義」を論文化、「漢方共通テストのシステム構築、実践、問題解説」を論文化、「漢方アクティブラーニング」を論文化、「漢方実習」を論文化、「医歯薬看におけるモデル・コア・カリキュラムと漢方教育」を論文化し、それぞれ日本東洋医学雑誌に公開された。

  3. Development of radical treatment with kampo medicine for multiple chemical sensitivity and elucidation of mechanism

    Ohsawa Minoru

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    We found goreisan to improve symptoms centered on "headache," which is the main symptom of multiple chemical sensitivity patients (CS patients, n = 8). When we examined the changes in each item (Q1 to Q5) of the diagnosis/severity questionnaire (QEESI) before and after the administration of goreisan in CS patients, a significant decrease was confirmed in Q3 (symptoms) (p = 0.016). In addition, when comparing untreated CS patients and non-CS patients with headaches (Non-CS patients, n = 20), the former was significantly higher in Q1 (chemical intolerance), Q2 (other substance intolerance), Q3 (symptoms), Q5 (disturbance of daily life). The fluid retention score was also significantly higher in the former before and after administration of goreisan in CS patients and in comparison with Non-CS patients.

  4. Experiments for investigating antiviral effect of Kampo formula using primary culture of human air way epithelial cells

    Kikuchi Akiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Kakkonto, a popular Kampo formula for common cold, did not significantly inhibit rhinovirus proliferation in human primary tracheal or nasal epithelial cells, but reduced acidic endosomes and inflammatory cytokines. Maoto or makyokansekito inhibited proliferation of influenza virus and inflammatory cytokines. These results indicated that kakkonto, maoto, and makyokansekito may have inhibitory effects of virus invasion into upper airway epithelial cells and restrain airway excessive inflammations.

  5. 基礎と臨床を橋渡しするヒト血清と培養細胞を用いた新たな漢方薬理研究法の開発

    沼田 健裕, 大場 浩史, 高山 真, 菊地 章子, 金子 聡一郎, 笠原 好之

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2016/04/01 - 2020/03/31

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    本研究課題の最終的な目的は、臨床研究においてヒトに漢方薬を投与し効果を検証する一方で、細胞実験や動物実験といった基礎研究を並行しておこなうことで、基礎と臨床の橋渡しとなる新たな実験モデルの開発を行うことであった。 当初の計画では初期の２年間で臨床研究を進めることとしていたが、実際には利益相反委員会や倫理委員会の承認を得るために、想定を超えた時間や労力を要し、臨床研究とそれに伴う細胞実験を開始できていない。平成29年度内に倫理委員会の承認は得られたものの平成30年度には研究代表者が異動となったために、倫理委員会へ再提出している。31年度には順に臨床研究と細胞基礎実験を進めてゆく予定である。当初計画のプロトコールに対して、倫理委員会より指導を受け、オープンラベルではなくクロスオーバーによる二重盲検ランダム化比較試験、また閉眼片足立ち時間ではなく、重心動揺検査をすることとなった。 一方、動物実験については順調に遂行できたためその実績概要を以下に示す。アルコール摂取に対する黄連解毒湯の効果を評価する目的で、C57BL6/J雄マウスに対して、黄連解毒湯を経口投与した1時間後にアルコールを経口投与し、アルコール投与後30分および1時間後における血中アルコールの濃度の測定を行った。アルコールは8％濃度と15％濃度の両方を評価した。黄連解毒湯の対照群には水を同量投与した。本検討の結果、黄連解毒湯の投与によっては血中アルコール濃度には変化は見られず、本検討では効果を見出すことは出来なかった。

  6. Press needle for aspiration pneumonia prevention in older adults: Study protocol for a randomized double-blind placebo-controlled trial

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2015/04/01 - 2020/03/31

  7. Improvement effect of tokishyakuyakusan for fundus circulation in normal tension glaucoma

    Takayama Shin

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2019/03/31

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    Thirteen healthy subjects received 3 kinds of kampo medicine. Tokishyakuyakusan increased fundus circulation. Nineteen healthy subjects received tokisyakuyakusan. The fundus circulation significantly increased fundus circulation from 30 minutes to 60 minutes compared with water drinking alone. Eleven patients of normal tension glaucoma received tokisyakuyakusan added to conventional treatment. Fundus circulation did not significantly change after 6 months administration.

  8. Effects of Daikenchuto and thermal therapy for the treatment of constipation in poststroke patients

    TAKAYAMA Shin, IWASAKI Koh, SEKI Takashi, KIKUCHI Akiko, TOBITA Muneshige, ISHIDA Syuichi, OIKAWA Takashi, AONUMA Takanori, KATAYOSE Dai, SHINKAWA Mitsutoshi, NUMATA Takehiro, KANEKO Soichiro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2011/04/28 - 2015/03/31

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    Poststroke patients with functional constipation were recruited in a study on the effects of the traditional Japanese medicine Daikenchuto (DKT). Thirty-four patients (mean age: 78 years) were randomly assigned to 2 groups; all patients received conventional therapy for constipation, and patients in the DKT group received 15g/day of DKT for 4 weeks. Constipation scoring system (CSS) points and the gas volume score (GVS) were recorded before and after a 4-week observation period. The total score on the CSS improved significantly in the DKT group compared to the control (p < 0.01). The GVS was also significantly reduced in the DKT group compared to the control (p = 0.03). DKT in addition to conventional therapy is effective in treating functional constipation in poststroke patients. Abdominal thermal stimulation (40 ℃, 15 minutes) tended to increase the superior mesenteric artery blood flow in poststroke patients (mean age: 79 years) with functional constipation (p = 0.065).

  9. 新規開発した円皮鍼を用いた誤嚥性肺炎の予防効果に関する研究

    菊地 章子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2010/04/01 - 2014/03/31

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    平成２４年度の実施計画では以下の３点を目標とした。 （１） 円皮鍼による刺激が嚥下反射を改善するという研究結果を報告する。 （２） 円皮鍼を貼付し続けることで誤嚥性肺炎の予防ができるかどうかを検討する。 （３） 鍼刺激が嚥下反射の改善に寄与するメカニズムを探る。 （１）に関しては、論文を作成し現在投稿中である。（２）の研究計画は、嚥下機能の低下している症例を、嚥下反射を改善する経穴に円皮鍼を貼付する群と貼付しない群に分けた。円皮鍼を貼付する群には連日医療従事者による貼り替えを行い、３か月、６か月、１２か月後の各群の嚥下反射と期間中の肺炎発症率・発熱日数・栄養状態の変化等を比較した。これまでに収集したデータの比較では、両群間の肺炎発症率・発熱日数・栄養状態の変化には有意な差は認められていない。両群間を十分に比較するにはさらにデータの数を増やすことが必要だが、これまでのところ円皮鍼を長期に貼付し続けることが誤嚥性肺炎の予防に寄与することは証明できなかった。（３）の研究計画は、鍼刺激が嚥下反射の改善に寄与するメカニズムを探るために、鍼刺激に対する頚部動脈の血流変化を高性能超音波診断装置にて測定するものであった。具体的には、６５歳以上の健常者と脳血管障害を持つ症例との二群に分け、嚥下反射を改善する経穴への鍼刺激により血圧、脈拍、内頸・外頸動脈の血流量等の変化を測定する。高性能超音波診断装置はベッドサイドに運搬することができないため、測定を行うには研究室まで協力者に来訪してもらわなければならない。脳血管障害を持つ高齢者は移動困難な方も多く、十分な数の協力者を集めるまでに至らなかった。

  10. 肺癌発症におけるヘムオキシゲナーゼ-1遺伝子多型に関する研究

    菊地 章子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2006 - 2006

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