Details of the Researcher

PHOTO

Shizuko Akiyama
Section
Tohoku University Hospital
Job title
Assistant Professor
Degree

  • 博士（医学）（東北大学）

Education 1

  • Tohoku University　Graduate School of Medicine

Research Areas 1

  • Life sciences / Fetal medicine/Pediatrics /

Papers 15

  1. Impact of high maternal body mass index on fetal cerebral cortical and cerebellar volumes Peer-reviewed

    Emiko Takeoka, April A. Carlson, Neel Madan, Afshin Azimirad, Taysir Mahmoud, Rie Kitano, Shizuko Akiyama, Hyuk Jin Yun, Richard Tucker, Kiho Im, Perrie O’Tierney-Ginn, Tomo Tarui

    Journal of Perinatal Medicine　2025/01/06

    Publisher: Walter de Gruyter GmbH

    DOI： 10.1515/jpm-2024-0222 　

    ISSN： 0300-5577

    eISSN： 1619-3997

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    Abstract Objectives Maternal obesity increases a child’s risk of neurodevelopmental impairment. However, little is known about the impact of maternal obesity on fetal brain development. Methods We prospectively recruited 20 healthy pregnant women across the range of pre-pregnancy or first-trimester body mass index (BMI) and performed fetal brain magnetic resonance imaging (MRI) of their healthy singleton fetuses. We examined correlations between early pregnancy maternal BMI and regional brain volume of living fetuses using volumetric MRI analysis. Results Of 20 fetuses, there were 8 males and 12 females (median gestational age at MRI acquisition was 24.3 weeks, range: 19.7–33.3 weeks, median maternal age was 33.3 years, range: 22.0–37.4 years). There were no significant differences in clinical demographics between overweight (OW, 25≤BMI<30)/obese (OB, BMI≥30 kg/m2) (n=12) and normal BMI (18.5≤BMI<25) (n=8) groups. Fetuses in the OW/OB group had significantly larger left cortical plate (p=0.0003), right cortical plate (p=0.0002), and whole cerebellum (p=0.049) compared to the normal BMI group. In the OW/OB BMI group, cortical plate volume was larger relative to other brain regions after 28 weeks. Conclusions This pilot study supports the concept that maternal obesity impacts fetal brain volume, detectable via MRI in living fetuses using quantitative analysis.

  2. 子宮内炎症に曝露された妊娠中期のヒツジ胎仔では副腎のコルチゾール合成酵素発現が亢進する

    佐藤 信一, 渡邊 真平, 佐原 寛太郎, 萩原 基実, 萩野 有正, 齊藤 裕也, 熊谷 祐作, 池田 秀之, 桜井 愛惠, 越浪 正太, 小林 昌枝, 秋山 志津子, 埴田 卓志, 齋藤 昌利

    日本周産期・新生児医学会雑誌　60　(Suppl.1)　P371-P371　2024/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  3. Comprehensive quantitative analyses of fetal magnetic resonance imaging in isolated cerebral ventriculomegaly Peer-reviewed

    Tomo Tarui, Neel Madan, George Graham, Rie Kitano, Shizuko Akiyama, Emiko Takeoka, Sophie Reid, Hyuk Jin Yun, Alexa Craig, Osamu Samura, Ellen Grant, Kiho Im

    NeuroImage: Clinical　37　103357-103357　2023/02/24

    Publisher: Elsevier BV

    DOI： 10.1016/j.nicl.2023.103357 　

    ISSN： 2213-1582

  4. Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study International-journal Peer-reviewed

    Shizuko Akiyama, Neel Madan, George Graham, Osamu Samura, Rie Kitano, Hyuk Jin Yun, Alexa Craig, Tomohiro Nakamura, Atsushi Hozawa, Ellen Grant, Kiho Im, Tomo Tarui

    PLOS ONE　17　(2)　e0263535-e0263535　2022/02/24

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0263535 　

    eISSN： 1932-6203

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    Dandy-Walker malformation (DWM) is a common prenatally diagnosed cerebellar malformation, characterized by cystic dilatation of the fourth ventricle, upward rotation of the hypoplastic vermis, and posterior fossa enlargement with torcular elevation. DWM is associated with a broad spectrum of neurodevelopmental abnormalities such as cognitive, motor, and behavioral impairments, which cannot be explained solely by cerebellar malformations. Notably, the pathogenesis of these symptoms remains poorly understood. This study investigated whether fetal structural developmental abnormalities in DWM extended beyond the posterior fossa to the cerebrum even in fetuses without apparent cerebral anomalies. Post-acquisition volumetric fetal magnetic resonance imaging (MRI) analysis was performed in 12 fetuses with DWM and 14 control fetuses. Growth trajectories of the volumes of the cortical plate, subcortical parenchyma, cerebellar hemispheres, and vermis between 18 and 33 weeks of gestation were compared. The median (interquartile range) gestational ages at the time of MRI were 22.4 (19.4–24.0) and 23.9 (20.6–29.2) weeks in the DWM and control groups, respectively (p = 0.269). Eight of the 12 fetuses with DWM presented with associated cerebral anomalies, including hydrocephalus (n = 3), cerebral ventriculomegaly (n = 3), and complete (n = 2) and partial (n = 2) agenesis of the corpus callosum (ACC); 7 presented with extracerebral abnormalities. Chromosomal abnormalities were detected by microarray analysis in 4 of 11 fetuses with DWM, using amniocentesis. Volumetric analysis revealed that the cortical plate was significantly larger in fetuses with DWM than in controls (p = 0.040). Even without ACC, the subcortical parenchyma, whole cerebrum, cerebellar hemispheres, and whole brain were significantly larger in fetuses with DWM (n = 8) than in controls (p = 0.004, 0.025, 0.033, and 0.026, respectively). In conclusion, volumetric fetal MRI analysis demonstrated that the development of DWM extends throughout the brain during the fetal period, even without apparent cerebral anomalies.

  5. Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging. International-journal Peer-reviewed

    Jinwoo Hong, Hyuk Jin Yun, Gilsoon Park, Seonggyu Kim, Yangming Ou, Lana Vasung, Caitlin K Rollins, Cynthia M Ortinau, Emiko Takeoka, Shizuko Akiyama, Tomo Tarui, Judy A Estroff, Patricia Ellen Grant, Jong-Min Lee, Kiho Im

    Frontiers in neuroscience　15　714252-714252　2021

    DOI： 10.3389/fnins.2021.714252 　

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    The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification of brain abnormalities and the risk of adverse developmental outcomes. This study aimed to propose a method for predicting fetal brain age using MRIs from 220 healthy fetuses between 15.9 and 38.7 weeks of gestational age (GA). We built a 2D single-channel convolutional neural network (CNN) with multiplanar MRI slices in different orthogonal planes without correction for interslice motion. In each fetus, multiple age predictions from different slices were generated, and the brain age was obtained using the mode that determined the most frequent value among the multiple predictions from the 2D single-channel CNN. We obtained a mean absolute error (MAE) of 0.125 weeks (0.875 days) between the GA and brain age across the fetuses. The use of multiplanar slices achieved significantly lower prediction error and its variance than the use of a single slice and a single MRI stack. Our 2D single-channel CNN with multiplanar slices yielded a significantly lower stack-wise MAE (0.304 weeks) than the 2D multi-channel (MAE = 0.979, p < 0.001) and 3D (MAE = 1.114, p < 0.001) CNNs. The saliency maps from our method indicated that the anatomical information describing the cortex and ventricles was the primary contributor to brain age prediction. With the application of the proposed method to external MRIs from 21 healthy fetuses, we obtained an MAE of 0.508 weeks. Based on the external MRIs, we found that the stack-wise MAE of the 2D single-channel CNN (0.743 weeks) was significantly lower than those of the 2D multi-channel (1.466 weeks, p < 0.001) and 3D (1.241 weeks, p < 0.001) CNNs. These results demonstrate that our method with multiplanar slices accurately predicts fetal brain age without the need for increased dimensionality or complex MRI preprocessing steps.

  6. Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome Peer-reviewed

    Hyuk Jin Yun, Juan David Ruiz Perez, Patricia Sosa, J Alejandro Valdés, Neel Madan, Rie Kitano, Shizuko Akiyama, Brian G Skotko, Henry A Feldman, Diana W Bianchi, P Ellen Grant, Tomo Tarui, Kiho Im

    Cerebral Cortex　31　(2)　757-767　2020/09

    Publisher: Oxford University Press ({OUP})

    DOI： 10.1093/cercor/bhaa255 　

    ISSN： 1047-3211

    eISSN： 1460-2199

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    <title>Abstract</title> Down syndrome (DS) is the most common genetic cause of developmental disabilities. Advanced analysis of brain magnetic resonance imaging (MRI) has been used to find brain abnormalities and their relationship to neurocognitive impairments in children and adolescents with DS. Because genetic factors affect brain development in early fetal life, there is a growing interest in analyzing brains from living fetuses with DS. In this study, we investigated regional sulcal folding depth as well as global cortical gyrification from fetal brain MRIs. Nine fetuses with DS (29.1 ± 4.24 gestational weeks [mean ± standard deviation]) were compared with 17 typically developing [TD] fetuses (28.4 ± 3.44). Fetuses with DS showed lower whole-brain average sulcal depths and gyrification index than TD fetuses. Significant decreases in sulcal depth were found in bilateral Sylvian fissures and right central and parieto-occipital sulci. On the other hand, significantly increased sulcal depth was shown in the left superior temporal sulcus, which is related to atypical hemispheric asymmetry of cortical folding. Moreover, these group differences increased as gestation progressed. This study demonstrates that regional sulcal depth is a sensitive marker for detecting alterations of cortical development in DS during fetal life, which may be associated with later neurocognitive impairment.

  7. 巨大な気腫性変化により致死的な呼吸不全を来した嚢胞形成性肺内リンパ管奇形の超早産児例

    池田 秀之, 吉田 茉莉恵, 桑名 翔大, 名和 達郎, 佐藤 信一, 渡邊 真平, 秋山 志津子, 埴田 卓志

    日本新生児成育医学会雑誌　31　(3)　895-895　2019/10

    Publisher: (公社)日本新生児成育医学会

    ISSN： 2189-7549

  8. Quantitative MRI Analyses of Regional Brain Growth in Living Fetuses with Down Syndrome Peer-reviewed

    Tomo Tarui, Kiho Im, Neel Madan, Rajeevi Madankumar, Brian G Skotko, Allie Schwartz, Christianne Sharr, Steven J Ralston, Rie Kitano, Shizuko Akiyama, Hyuk Jin Yun, Ellen Grant, Diana W Bianchi

    Cerebral Cortex　30　(1)　382-390　2019/07/02

    Publisher: Oxford University Press ({OUP})

    DOI： 10.1093/cercor/bhz094 　

    ISSN： 1047-3211

    eISSN： 1460-2199

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    <title>Abstract</title> Down syndrome (DS) is the most common liveborn autosomal chromosomal anomaly and is a major cause of developmental disability. Atypical brain development and the resulting intellectual disability originate during the fetal period. Perinatal interventions to correct such aberrant development are on the horizon in preclinical studies. However, we lack tools to sensitively measure aberrant structural brain development in living human fetuses with DS. In this study, we aimed to develop safe and precise neuroimaging measures to monitor fetal brain development in DS. We measured growth patterns of regional brain structures in 10 fetal brains with DS (29.1 ± 4.2, weeks of gestation, mean ± SD, range 21.7~35.1) and 12 control fetuses (25.2 ± 5.0, range 18.6~33.3) using regional volumetric analysis of fetal brain MRI. All cases with DS had confirmed karyotypes. We performed non-linear regression models to compare fitted regional growth curves between DS and controls. We found decreased growth trajectories of the cortical plate (P = 0.033), the subcortical parenchyma (P = 0.010), and the cerebellar hemispheres (P &amp;lt; 0.0001) in DS compared to controls. This study provides proof of principle that regional volumetric analysis of fetal brain MRI facilitates successful evaluation of brain development in living fetuses with DS.

  9. P1201-22-PM 向精神薬服用妊婦に対して行った授乳に関する情報提供の現状(妊婦・授乳婦,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-) Peer-reviewed

    八島 一史, 菊地 紗耶, 小林 奈津子, 久道 周彦, 眞野 成康, 中川 直人, 小原 拓, 千葉 和美, 山本 美由紀, 西郡 秀和, 加藤 佳子, 松浦 正樹, 秋山 志津子

    日本医療薬学会年会講演要旨集　25　(0)　466-466　2015

    Publisher: 一般社団法人 日本医療薬学会

    DOI： 10.20825/amjsphcs.25.0_466_1 　

  10. 成育限界児の慢性肺疾患に対する長期NO吸入療法の有効性

    秋山 志津子, 松田 直, 名和 達郎, 小野 寿和, 臼田 治夫, 新関 昌枝, 北西 龍太, 埴田 卓志, 渡辺 達也

    日本未熟児新生児学会雑誌　25　(3)　467-467　2013/11

    Publisher: (公社)日本新生児成育医学会

    ISSN： 1347-8540

  11. 後天性サイトメガロウイルス感染症を発症した超低出生体重児の臨床像

    新関 昌枝, 松田 直, 名和 達郎, 小野 寿和, 藤田 基資, 伊藤 智子, 臼田 治夫, 秋山 志津子, 北西 龍太, 埴田 卓志, 渡辺 達也

    日本未熟児新生児学会雑誌　25　(3)　503-503　2013/11

    Publisher: (公社)日本新生児成育医学会

    ISSN： 1347-8540

  12. Designing artificial environments for preterm infants based on circadian studies on pregnant uterus. International-journal Peer-reviewed

    Shimpei Watanabe, Shizuko Akiyama, Takushi Hanita, Heng Li, Machiko Nakagawa, Yousuke Kaneshi, Hidenobu Ohta

    Frontiers in endocrinology　4　113-113　2013/09/04

    DOI： 10.3389/fendo.2013.00113 　

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    Using uterine explants from Per1::Luc rats and in situ hybridization, we recently reported that the circadian property of the molecular clock in the uterus and placenta is stably maintained from non-pregnancy, right through to the end stage of pregnancy under regular light-dark (LD) cycles. Despite long-lasting increases in progesterone during gestation and an increase in estrogen before delivery, the uterus keeps a stable Per1::Luc rhythm throughout the pregnancy. The study suggests the importance of stable circadian environments for fetuses to achieve sound physiology and intrauterine development. This idea is also supported by epidemiological and animal studies, in which pregnant females exposed to repeated shifting of the LD cycles have increased rates of reproductive abnormalities and adverse pregnancy outcomes. Leading from this, we introduced artificial circadian environments with controlled lighting conditions to human preterm infants by developing and utilizing a specific light filter which takes advantage of the unique characteristics of infants' developing visual photoreceptors. In spite of growing evidence of the physiological benefits of nighttime exposure to darkness for infant development, many Japanese Neonatal Intensive Care Units (NICUs) still prefer to maintain constant light in preparation for any possible emergencies concerning infants in incubators. To protect infants from the negative effects of constant light on their development in the NICU, we have developed a new device similar to a magic mirror, by which preterm infants can be shielded from exposure to their visible wavelengths of light even in the constant light conditions of the NICU while simultaneously allowing medical care staff to visually monitor preterm infants adequately. The device leads to significantly increased infant activity during daytime than during night time and better weight gains.

  13. 内分泌機能に大きく依存する新生児の循環調節 バゾプレッシンの循環器系に及ぼす影響

    松田 直, 加賀 麻衣子, 臼田 治夫, 伊藤 智子, 渡邊 真平, 小野寺 幸子, 新関 昌枝, 秋山 志津子, 北西 隆太, 渡邉 達也

    日本周産期・新生児医学会雑誌　49　(1)　165-167　2013/05

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  14. The uterus sustains stable biological clock during pregnancy. Peer-reviewed

    Shizuko Akiyama, Hidenobu Ohta, Shimpei Watanabe, Takahiro Moriya, Aya Hariu, Norimichi Nakahata, Hiroshi Chisaka, Tadashi Matsuda, Yoshitaka Kimura, Shigeru Tsuchiya, Hajime Tei, Kunihiro Okamura, Nobuo Yaegashi

    The Tohoku journal of experimental medicine　221　(4)　287-98　2010/08

    eISSN： 1349-3329

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    Maternal circadian information has been reported to play an important role in fetal physiology and development. Hormones and nutrition have been mainly investigated as circadian cues from mother to fetus. However, the influences of circadian properties of the pregnant reproductive organs on fetuses have not been fully investigated. To gain an insight on the circadian functions of the reproductive organs, we examined molecular clocks in the pregnant rat uterus and placenta. By using a Period1-luciferase (Per1-luc) rat, whose tissues express luciferase corresponding to activation of Period1, a "key clock gene", we examined the uterus clock during non-pregnancy, on embryonic day 12 (E12), and on E22 (the end of pregnancy) in a light-dark (LD) cycle and constant darkness (DD). By in situ hybridization we further explored Per1 mRNA rhythms in the placenta on E12 and E22. The uterus in vitro showed clear circadian Per1-luc rhythms both in and out of pregnancy, having peaks at around the time corresponding to dusk in LD. Likewise, in DD, the uterus in vitro had the same Per1-luc rhythms. The decidua in LD showed circadian Per1 mRNA rhythms, peaking during night 6 h after dusk, while the decidua in DD showed the same Per1 mRNA rhythms only on E22. In contrast, the labyrinth showed no circadian Per1 mRNA rhythms in LD or DD during pregnancy. These results suggest that the uterus and decidua, a maternally-originated tissue of the placenta, but not the labyrinth, a fetus-originated tissue of the placenta, can provide the fetus with circadian information.

  15. [Erratum] The Uterus Sustains Stable Biological Clock during Pregnancy. Peer-reviewed

    Akiyama Shizuko, Ohta Hidenobu, Watanabe Shimpei, Moriya Takahiro, Hariu Aya, Nakahata Norimichi, Chisaka Hiroshi, Matsuda Tadashi, Kimura Yoshitaka, Tsuchiya Shigeru, Tei Hajime, Okamura Kunihiro, Yaegashi Nobuo

    Tohoku J Exp Med　222　(2)　165-165　2010/04

    DOI： 10.1620/tjem.221.287 　

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Misc. 23

  1. 一酸化窒素吸入療法を要した慢性肺疾患患児20例の後方視的検討

    矢内 敦, 萩原 基実, 萩原 有正, 高梨 愛佳, 桜井 愛惠, 越浪 正太, 佐藤 信一, 小林 昌枝, 渡邊 真平, 秋山 志津子, 植田 卓志

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P284-P284　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  2. 先天性食道閉鎖症と先天性十二指腸閉鎖症を合併した極低出生体重児の一例

    萩原 基実, 大久保 龍二, 矢内 敦, 武蔵 尭志, 熊坂 衣織, 萩野 有正, 高梨 愛佳, 桜井 愛惠, 越浪 正太, 佐藤 信一, 小林 昌枝, 渡邊 真平, 秋山 志津子, 埴田 卓志, 和田 基

    日本周産期・新生児医学会雑誌　59　(Suppl.1)　P408-P408　2023/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  3. 多期的手術により在宅人工呼吸管理に移行できた食道閉鎖症D型・Floyd I型気管無形成の一例

    矢内 敦, 佐藤 信一, 崔 実結, 佐原 寛太郎, 武蔵 尭志, 及川 剛, 熊坂 衣織, 萩野 有正, 萩原 基実, 高梨 愛佳, 池田 秀之, 桜井 愛惠, 小林 昌枝, 渡邊 真平, 秋山 志津子, 埴田 卓志, 笹原 洋二

    日本小児科学会雑誌　127　(2)　209-209　2023/02

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  4. 多期的手術を要した食道閉鎖症D型に合併したFloyd I型気管無形成の1例

    矢内 敦, 佐藤 信一, 桜井 愛恵, 小林 昌枝, 渡邊 真平, 秋山 志津子, 埴田 卓志

    日本新生児成育医学会雑誌　34　(3)　495-495　2022/10

    Publisher: (公社)日本新生児成育医学会

    ISSN： 2189-7549

  5. 心筋緻密化障害を合併したfetal akinesia deformation sequenceの1剖検例

    武蔵 尭志, 佐藤 信一, 渡邊 真平, 秋山 志津子, 埴田 卓志

    日本新生児成育医学会雑誌　34　(3)　502-502　2022/10

    Publisher: (公社)日本新生児成育医学会

    ISSN： 2189-7549

  6. 胎児脳MRI定量解析による妊娠初期の母体BMIと胎児脳の成長との関連

    武岡 恵美子, 北野 理絵, 秋山 志津子

    日本周産期・新生児医学会雑誌　58　(Suppl.1)　338-338　2022/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

    eISSN： 2435-4996

  7. 大学病院からの訪問診療

    田中 総一郎, 呉 繁夫, 鈴木 徹郎, 松田 直, 秋山 志津子, 笹原 洋二, 渡辺 祐子, 新妻 秀剛, 植松 貢, 植松 有里佳

    日本小児科学会雑誌　120　(10)　1552-1552　2016/10

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  8. ラット羊水腔内に鉄を投与することにより胎仔肺発育が遅延する

    渡辺 達也, 松田 直, 名和 達郎, 小野 寿和, 臼田 治夫, 新関 昌枝, 秋山 志津子, 北西 龍太, 埴田 卓志

    日本未熟児新生児学会雑誌　25　(3)　469-469　2013/11

    Publisher: (一社)日本新生児成育医学会

    ISSN： 1347-8540

  9. ヒト光受容体の発達と早産児の睡眠

    太田 英伸, 渡辺 真平, 秋山 志津子, 埴田 卓志, 李 コウ

    日本睡眠学会定期学術集会プログラム・抄録集　38回　171-171　2013/06

    Publisher: (一社)日本睡眠学会

  10. バゾプレッシンの循環器系に及ぼす影響

    松田 直, 加賀 麻衣子, 臼田 治夫, 伊藤 智子, 渡邊 真平, 小野寺 幸子, 新関 昌枝, 秋山 志津子, 北西 隆太, 渡邉 達也

    日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine　49　(1)　165-167　2013/05/20

    ISSN： 1348-964X

  11. 胎児期に心房粗動と診断され早期娩出した低出生体重児の1例

    新田恩, 松田直, 井上若葉, 荒井那津子, 渡辺真平, 秋山志津子, 北西龍太, 渡辺達也, 田澤星一, 柿崎周平

    周産期医学　41　(9)　1222-1225　2011

  12. 胎児・新生児期における生物時計と光環境の重要性 (特集 概日リズム睡眠障害と関連する諸問題) -- (概日リズム睡眠障害に関連したトピックス)

    渡邊 真平, 秋山 志津子, 太田 英伸

    睡眠医療　5　(1)　47-54　2011

    Publisher: ライフ・サイエンス

    ISSN： 1882-2096

  13. 光フィルターによる早産児の睡眠覚醒サイクルの制御

    太田 英伸, 秋山 志津子, 渡辺 真平, 松田 直, 渡辺 達也, 斎藤 潤子, 今井 香織, 佐藤 智樹, 上田 恵子, 池田 智明, 八重樫 伸生

    日本未熟児新生児学会雑誌　22　(3)　522-522　2010/10

    Publisher: (一社)日本新生児成育医学会

    ISSN： 1347-8540

  14. 血球貪食性リンパ組織球症で発症した先天性サイトメガロウイルス感染の超低出生体重児

    渡邊 真平, 松田 直, 秋山 志津子, 北西 龍太, 三浦 雄一郎, 埴田 卓志, 植松 貢, 笹原 洋二, 土屋 滋

    日本小児科学会雑誌　113　(12)　1884-1885　2009/12

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  15. 血球貪食症候群で発症した先天性サイトメガロウイルス感染の超低出生体重児

    渡邊 真平, 松田 直, 秋山 志津子, 北西 龍太, 三浦 雄一郎, 埴田 卓志, 笹原 洋二, 土屋 滋

    日本小児科学会雑誌　113　(9)　1445-1445　2009/09

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  16. 血球貪食症候群で発症した先天性サイトメガロウイルス感染の超低出生体重児

    渡邊 真平, 松田 直, 秋山 志津子, 三浦 雄一郎, 埴田 卓志

    日本周産期・新生児医学会雑誌　45　(2)　537-537　2009/06

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

  17. Hemophagocytic Lymphohistiocytosis Associated with Congenital Cytomegalovirus Infection in an Extreme Low Birth Weight Infant

    19　(1)　"S-129"-"S-130"　2009/05/01

    ISSN： 0916-8796

  18. 急性発症した双胎間輸血症候群の1例

    渡邊 真平, 松田 直, 秋山 志津子, 北西 龍太, 三浦 雄一郎, 埴田 卓志, 土屋 滋

    日本小児科学会雑誌　113　(4)　753-753　2009/04

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  19. 長期低酸素療法を施行したが、心不全にて体重増加が得られなかった両大血管右室起始症を合併した極低出生体重児の1例

    秋山 志津子, 松田 直, 渡辺 真平, 川合 英一郎, 北西 龍太, 三浦 雄一郎, 埴田 卓志, 土屋 滋

    日本小児科学会雑誌　113　(1)　153-153　2009/01

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  20. 脳性麻痺は防止できるか? 子宮内炎症と神経細胞死

    松田 直, 斉藤 昌利, 渡辺 達也, 埴田 卓志, 三浦 雄一郎, 北西 龍太, 秋山 志津子, 渡辺 真平, 岡村 州博

    日本周産期・新生児医学会雑誌　44　(4)　863-867　2008/12

    Publisher: (一社)日本周産期・新生児医学会

    ISSN： 1348-964X

  21. 急性発症の重症双胎間輸血症候群

    三浦 雄一郎, 松田 直, 佐藤 正規, 秋山 志津子, 北西 龍太, 埴田 卓志, 渡辺 達也

    日本未熟児新生児学会雑誌　20　(3)　531-531　2008/10

    Publisher: (一社)日本新生児成育医学会

    ISSN： 1347-8540

  22. 長期生存中の致死性骨系統疾患4例の臨床像

    川合 英一郎, 松田 直, 渡邉 達也, 埴田 卓志, 三浦 雄一郎, 北西 龍太, 秋山 志津子, 渡辺 真平, 藤原 幾磨

    日本小児科学会雑誌　112　(9)　1431-1431　2008/09

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

  23. 低酸素換気療法により救命できた肺血流増加型心奇形を合併した低出生体重児の3例

    北西 龍太, 松田 直, 佐藤 正規, 新田 恩, 秋山 志津子, 三浦 雄一郎, 埴田 卓志, 岩岡 亜理, 渡邉 達也, 大野 忠行, 土屋 滋

    日本小児科学会雑誌　112　(3)　532-532　2008/03

    Publisher: (公社)日本小児科学会

    ISSN： 0001-6543

Show all ︎Show first 5

Books and Other Publications 1

  1. 周産期マニュアル : 胎児疾患の診断から管理まで

    佐村, 修, 宗田, 聡

    南山堂　2023/06

    ISBN: 9784525332013

Research Projects 5

  1. 新生児脳MRIを用いた早期発症型胎児発育不全児の神経発達予後予測指標の開発．

    秋山 志津子

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2023/04/01 - 2026/03/31

  2. Elucidation of the mechanism of developmental fetal organ damage caused by stress-induced overmaturation

    MATSUDA TADASHI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2015/04/01 - 2019/03/31

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    The study was performed to analyze the influence of intrauterine inflammation to adrenocortical ability and to make clear that the inflammation could promote the maturation of fetal brain, adrenal cortex and ductus arteriosus using chronically instrumented premature fetal sheep. The fetuses were divided into two groups; control (n=9) and inflammation groups (n=11). We carried out CRH loading test. There was no difference between the two groups in the change of ACTH concentration (p=0.209) over time, but a significant difference in the change of cortisol (p=0.016). In the histological examination of ductus arteriosus, no difference was found between the two in the developmental score. The results could not suggest that the intrauterine inflammation would promote intimal thickening development of fetal ductus arteriosus. There is a need for further histological examination of the brain and adrenal cortex to make clear the intrauterine inflammation could promote the fetal overmaturation.

  3. Pathogenesis of insufficient adrenocortical response in premature fetal sheep suffered from intrauterine inflammation

    Akiyama Shizuko, MATSUDA TADASHI, SAITO MASATOSHI, WATANABE TATSUYA

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    We planed to clarify the effect of intrauterine inflammation on the cortisol secretion and its circulatory response in premature lamb because the fetal endocrine potential to adapt the postnatal environment might have been already deteriorated by the inflammatory stress before birth. In consequence, we could store the plasma samples for 45 times of the corticotrophin releasing hormone test. Unfortunately, however, commercial kits for immunoassay of sheep AVP, ACTH and cortisol could not be available domestically during the study period. Instead, we have been developing the method of peptides and steroid profiling analysis using the LC-MS/MS.

  4. The effect of cerebral white matter injury on the subsequent myelination in premature fetal sheep

    MATSUDA TADASHI, WATANABE Tatsuya, MATSUDA Tadashi, AKIYAMA Shizuko, ONODERA Sachiko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2012/04/01 - 2015/03/31

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    We analyzed the association between histopathologic findings and magnetic resonance images using sheep fetuses experimentally induced cerebral white matter injury (WMI) by ischemic insults. First, all lesions of focal WMI were clearly observed as at once a high intensity spot of T1 weighted image and a low intensity spot of T2 weighted image in the magnetic resonance imaging. Second, diffuse WMI lesion was possibly shown as a high intensity region of T2 weighted image in the subacute phase (2-5 days) after the insults. In addition, an electron microscopic analysis might be quite useful to understand and detect the over-maturity of myelination induced by diffuse WMI.

  5. Analysis of magnetic resonance imaging in cerebral white matter injury using chronically instrumented fetal sheep

    AKIYAMA Shizuko

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2010 - 2012

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    We analyzed the magnetic resonance imaging (MRI) in the cerebral white matter injury (WMI) using chronically instrumented fetal sheep, suffered from ischemia and/or inflammation in utero. Abnormal MRI signals were found in 5 fetuses induced focal WMI while unexpectedly also found in 3 fetuses not induced WMI, as a focal low T1, diffuse high T2 or focal high T1 /low T2 intensity. It might be possible that these abnormal signals observed in the latter group reflected histologic changes in acute phase of diffuse WMI, clinically more important than focal WMI. Consequently, it would be necessary to be evaluated the oligodendroglial development in the white matter by adding the immuno-histochemical analysis as a next step.