TOHOKU UNIVERSITY Researchers - Shinichi Kuriyama

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Shinichi Kuriyama

Section

International Research Institute of Disaster Science

Job title

Professor

Degree

博士（医学）（東北大学）

researchmap

https://researchmap.jp/read0163725

J-GLOBAL ID

200901083124921423

Profile

1987年東北大学理学部物理学科卒業、1993年大阪市立大学医学部医学科を卒業後、大阪市立大学医学部附属病院第３内科医師、民間企業医師、2003年東北大学大学院医学系研究科公衆衛生学分野助手、2005年同講師、2006年同助教授、2010年東北大学大学院医学系研究科環境遺伝医学総合研究センター分子疫学分野教授を経て、2012年に東北大学災害科学国際研究所災害公衆衛生学分野教授に就任、現在に至る。

Education 1

Osaka City University

- 1993/03

Committee Memberships 5

日本疫学会　理事

2018/02 - Present
日本疫学会　評議員

2008/01 - Present
日本疫学会　評議員

2008/01 - Present
日本乳癌検診学会　評議員

2007/02 - Present
日本乳癌検診学会　評議員

2007/02 - Present

Professional Memberships 5

日本乳癌検診学会(2007/02- 評議員)
日本公衆衛生学会
日本小児神経学会
日本人類遺伝学会
日本疫学会(2008/01- 評議員)

Research Interests 4

公衆衛生学
疫学
神経疾患の成因解明研究
生活習慣病の分子疫学研究、神経疾患の成因解明研究、疫学、公衆衛生学

Research Areas 3

Life sciences / Healthcare management, medical sociology /
Life sciences / Hygiene and public health (non-laboratory) /
Life sciences / Hygiene and public health (laboratory) /

Awards 3

東北大学医学部奨学賞金賞

2008/01/18　東北大学医学部
宮城県医師会医学奨励賞金賞

2008/01/05　宮城県医師会
日本疫学会奨励賞

2006/01　日本疫学会

Papers 561

Sex difference of genetic risk in the prevalence of atrial fibrillation. International-journal

Sayuri Tokioka, Masato Takase, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Heart rhythm　2025/03/23

DOI： 10.1016/j.hrthm.2025.03.1974 　

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BACKGROUND: Early detection and management of atrial fibrillation (AF) are crucial. Combined models incorporating genetic risks and clinical risks have been developed to improve predictive ability. Although sex differences have been reported in many aspects of AF, sex differences in genetic risk have not been studied. OBJECTIVE: To assess the sex difference in the effect of AF-PRS on AF prevalence using cross-sectional data from the Tohoku Medical Megabank Project Community-Based Cohort Study in Japan. METHODS: Polygenic risk score for AF (AF-PRS) and Cohorts for Heart and Aging Research in Genomic Epidemiology AF (CHARGE-AF) score were used for genetic AF risks and clinical AF risks, respectively. Sex differences in the association of AF-PRS with the prevalence of AF were evaluated. RESULTS: Among 16,853 participants (mean age, 63.4 years and 30.7% men), the prevalence of AF was 4.9% in men and 1.1% in women. In the group with high AF-PRS and high CHARGE-AF score, the odds ratio for AF was highest in men and women (8.2 in men and 9.4 in women), compared to that in the group with low AF-PRS and low CHARGE-AF score. Integrating AF-PRS into the CHARGE-AF score significantly enhanced the area under the curve of receiver operating characteristic for AF in men (from 0.639 to 0.749) but not in women (from 0.710 to 0.733). CONCLUSION: Our study is the first to show a sex difference in the association of AF-PRS and AF prevalence. AF-PRS is more closely associated with the prevalence of AF in men than in women.
Association between paternal physique and obesity in children at the age of 3 years: the Japan Environment and Children's Study. International-journal

Yui Inoue, Maki Yokoyama, Shota Inoue, Matome Imai, Hiroshi Onji, Akiko Yano, Yuka Uchikura, Yuko Matsubara, Keiichi Matsubara, Hirotaka Hamada, Hasumi Tomita, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito, Takashi Sugiyama

Journal of developmental origins of health and disease　16　e17　2025/03/21

DOI： 10.1017/S2040174424000473 　

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Obesity during development has been reported to be a determinant factor in the future development of non-communicable diseases (NCDs). Parental obesity is suggested to be a predictor of children's obesity, and it is important to consider parental factors to prevent NCDs in the progeny. Previously, we showed that paternal height had a stronger association with infant birth weight than paternal body mass index (BMI) in the Japanese population. However, only a few studies have examined the association between paternal physique and postnatal obesity. This study aimed to investigate the association between parental physique and obesity in children at the age of 3. This study used fixed data on 33,291 parent-child pairs from the Japan Environment and Children's Study, an ongoing national birth cohort study. The association between paternal physique (BMI and height) and children's obesity at the age of 3 was examined using multivariate logistic regression analysis. The higher the paternal BMI quartiles, the higher the odds ratio for obesity in male and female children at 3 years of age (P < 0.0001). However, paternal height quartiles were not associated with male or female obesity. These results differ from the association between paternal physique and infant birth weight, and it is possible that prenatal epigenetic and environmental factors of paternal origin were responsible for the differences between these two studies. The association between paternal BMI and obesity in children at the age of 3 suggests that paternal factors may be involved in the development of NCDs in future progeny.
Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. International-journal

Tomoki Kawahara, Nobutoshi Nawa, Keiko Murakami, Toshihiro Tanaka, Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Masatsugu Orui, Aoi Noda, Genki Shinoda, Yuki Nagata, Satoshi Nagaie, Soichi Ogishima, Junichi Sugawara, Shigeo Kure, Kengo Kinoshita, Atsushi Hozawa, Nobuo Fuse, Gen Tamiya, Wendy L Bennett, Margaret A Taub, Pamela J Surkan, Shinichi Kuriyama, Takeo Fujiwara

Journal of human genetics　2025/03/21

DOI： 10.1038/s10038-025-01330-4 　

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Gestational diabetes mellitus (GDM) is common in Japanese women, posing serious risks to mothers and offspring. This study investigated the influence of maternal genotypes on the risk of GDM and examined how these genotypes modify the effects of psychological and dietary factors during pregnancy. We analyzed data from 20,399 women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort. Utilizing two customized SNP arrays for the Japanese population (Affymetrix Axiom Japonica Array v2 and NEO), we performed a meta-analysis to combine the datasets. Gene-environment interactions were assessed by modeling interaction terms between genome-wide significant single nucleotide polymorphisms (SNPs) and psychological and dietary factors. Our analysis identified two SNP variants, rs7643571 (p = 9.14 × 10-9) and rs140353742 (p = 1.24 × 10-8), located in an intron of the MDFIC2 gene, as being associated with an increased risk of GDM. Additionally, although there were suggestive patterns for interactions between these SNPs and both dietary factors (e.g., carbohydrate and fruit intake) and psychological distress, none of the interaction terms remained significant after Bonferroni correction (p < 0.05/8). While nominal significance was observed in some models (e.g., psychological distress, p = 0.04), the data did not provide robust evidence of effect modification on GDM risk once adjusted for multiple comparisons. These findings reveal novel genetic associations with GDM in Japanese women and highlight the importance of gene-environment interactions in its etiology. Given that previous genome-wide association studies (GWAS) on GDM have primarily focused on Western populations, our study provides new insights by examining an Asian population using a population-specific array.
Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. International-journal

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

Nutrition (Burbank, Los Angeles County, Calif.)　135　112739-112739　2025/03/08

DOI： 10.1016/j.nut.2025.112739 　

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OBJECTIVES: Adiposity rebound (AR) corresponds to the start of the second rise in the body mass index curve during infant growth. Early AR (before age 5) confers increased risk of adiposity and metabolic disorders but is less likely to occur in breastfed infants. Although lipids in breast milk are important in child growth, information is limited regarding which lipids are involved in AR. The object of this study was to explore the association between breast milk lipids and AR status in children. METHODS: We designed a case-control study of 184 mother-child pairs (AR cases: n = 93; controls: n = 91) included from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Breast milk was collected 1 month postpartum and comprehensive lipid analysis was performed. Partial least square-discriminant analysis was used to explore candidate lipids, and multivariable logistic regression analysis was used to evaluate associations with the AR status of children. RESULTS: We detected 667 lipid molecules in 12 lipid classes in breast milk. Partial least square-discriminant analysis revealed the association of fatty acid-hydroxy fatty acid (FAHFA) and cholesterol ester (ChE) with AR status. Multivariable logistic regression analysis showed that in pairs with exclusive breastfeeding at 1 month postpartum, FAHFA (odds ratio 1.57 [95% confidence interval, 1.06-2.32]) was positively associated with early AR, and ChE (odds ratio 0.55 [95% confidence interval, 0.36-0.86]) was negatively associated. CONCLUSIONS: Breast milk lipids (FAHFA, ChE) associated with the AR status of children, indicating the potential to regulate a child's adiposity and possible metabolic disorders in adulthood.
Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case-Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Kento Sawane, Ippei Takahashi, Mami Ishikuro, Hiroko Takumi, Masatsugu Orui, Aoi Noda, Genki Shinoda, Hisashi Ohseto, Tomomi Onuma, Fumihiko Ueno, Keiko Murakami, Naoko Higuchi, Tomoko Tanaka, Takashi Furuyashiki, Tomohiro Nakamura, Seizo Koshiba, Kinuko Ohneda, Kazuki Kumada, Soichi Ogishima, Atsushi Hozawa, Junichi Sugawara, Shinichi Kuriyama, Taku Obara

The Journal of nutrition　2025/03/07

DOI： 10.1016/j.tjnut.2025.02.024 　

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BACKGROUND: Adiposity rebound (AR) is the point when the body mass index (BMI) begins to rise again during early childhood. Early AR (before age 5) is associated with a higher risk of lifelong obesity and metabolic disorders and may be influenced by breastfeeding. Although human milk oligosaccharides (HMOs) in breast milk are crucial for child growth, their association with AR status has not been studied. OBJECTIVE: To explore breast milk HMO compositions and molecules associated with AR status in children. METHODS: In this case-control study, we included 184 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation (TMM BirThree) Cohort Study (93 AR cases, 91 controls). Breast milk was collected 1 month postpartum, and the concentration of 15 HMO molecules and alpha-diversity index (Inverse Simpson index) were quantified. Wilcoxon's rank-sum test and partial least squares-discriminant analysis (PLS-DA) identified candidate HMOs, and multivariable logistic regression analysis evaluated associations between candidate HMOs and AR status. Analyses were stratified by maternal secretor status (secretor or non-secretor). RESULTS: In secretor mothers, multivariable logistic regression showed that the Inverse Simpson index (OR, 0.54 [95% CI, 0.36-0.82]), sum of sialic acid-bound HMOs (0.61 [0.41-0.91]), and 3'-sialyllactose (0.67 [0.46-0.98]) were inversely associated with early AR in a fully adjusted model. A trend of interaction between sialyl-lacto-N-tetraose a (LSTa) and maternal secretor status on AR was observed in a fully adjusted model (P-value for interaction = 0.051). CONCLUSIONS: Alpha diversity, sialic acid-bound HMOs, and 3'SL may be involved in inhibiting AR in children of secretor mothers, and a trend of interactive effect of LSTa among maternal secretor status on AR was indicated. These findings offer novel perspectives on the associations between breastfeeding and a child's adiposity as well as potential metabolic disorders later in life. REGISTRY NUMBER/WEBSITE: https://www.umin.ac.jp/ (trial registration number: UMIN000047160).
Impact of maternal smoking and secondhand smoke exposure during singleton pregnancy on placental abruption: analysis of a prospective cohort study (the Japan Environment and Children's Study). International-journal

Hikaru Karumai-Mori, Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

BMJ open　15　(3)　e089499　2025/03/04

DOI： 10.1136/bmjopen-2024-089499 　

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OBJECTIVES: This study aimed to investigate the association and population-attributable fraction (PAF) of maternal smoking and secondhand smoke (SHS) exposure during pregnancy with placental abruption. DESIGN: Prospective cohort study. SETTING: 15 regional centres in Japan. PARTICIPANTS: Pregnant women registered between January 2011 and March 2014 from the Japan Environment and Children's Study. OUTCOME MEASURES: Data were transcribed from medical records and two self-administered questionnaires. The outcome measure was the incidence of placental abruption. Maternal smoking exposure during pregnancy was categorised based on the number of cigarettes smoked (≤10 or ≥11 cigarettes per day). SHS exposure during pregnancy was evaluated by frequency and duration (almost never or never, 1-3 days/week and/or <1 hour/day and 4-7 days/week and ≥1 hour/day). A modified Poisson regression model, adjusted for known placental abruption risk factors, calculated the risk ratio (RR) and PAF for placental abruption with a 95% Cl. RESULTS: Of the 81 974 eligible pregnant women, pregnant women smoking ≥11 cigarettes/day during pregnancy had a significantly higher risk of placental abruption. The adjusted RR (aRR) was 2.21 (95% CI 1.21 to 4.06), and the adjusted PAF (aPAF) was 1.90% (95% CI 0.09 to 3.71%). Pregnant women among never-smokers with SHS exposure of 4-7 days/week and ≥1 hour/day had a significantly higher risk (aRR: 2.34, 95% CI 1.29 to 4.28), and the aPAF was 1.89% (95% CI -0.05 to 3.83). Additionally, pregnant women among those who smoked during pregnancy with similar SHS exposure had a significantly higher risk (aRR: 2.21, 95% CI 1.30 to 3.76), with the aPAF of 2.29% (95% CI 0.11 to 4.48). CONCLUSIONS: Maternal smoking and SHS exposure during pregnancy significantly contribute to the risk of placental abruption in Japan. Therefore, preventive interventions and measures to reduce exposure are required to prevent placental abruption.
Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project.

Naoko Mori, Shunji Mugikura, Atsushi Hozawa, Makiko Taira, Hiroaki Hashizume, Atsushi Sekiguchi, Mitsunari Abe, Michiyo Kasai, Tomo Saito, Kengo Kinoshita, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto

The Tohoku journal of experimental medicine　2025/01/16

DOI： 10.1620/tjem.2025.J006 　
Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　2025/01/11

DOI： 10.1111/jdi.14400 　

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AIMS: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM). METHODS: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years. RESULTS: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively. CONCLUSIONS: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.
Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation.

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Masato Takase, Kotaro Nochioka, Kai Susukita, Hirohito Metoki, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Satoshi Yasuda, Atsushi Hozawa

Circulation journal : official journal of the Japanese Circulation Society　2025/01/11

DOI： 10.1253/circj.CJ-24-0780 　

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BACKGROUND: The primary prevention of atrial fibrillation (AF), which increases mortality through complications including stroke and heart failure, is important. Excessive salt intake and low potassium intake are risk factors for cardiovascular disease; however, their association with AF remains inconclusive. This study investigated the association between sodium- and potassium-related urinary markers and AF prevalence. METHODS AND RESULTS: Data from the Tohoku Medical Megabank Project Community-based Cohort Study were used in this cross-sectional study. The urinary sodium-to-potassium (Na/K) ratio and estimated 24-h sodium and potassium excretion were calculated using spot urine samples and categorized into quartiles (Q1-Q4). The prevalence of AF was the primary outcome. Of the 26,506 participants (mean age 64.8 years; 33.2% males) included in this study, 630 (2.4%) had AF. Using Q1 as the reference group, the odds ratios for AF prevalence in Q4 were 1.35 (95% confidence interval [CI] 1.07-1.73) and 1.59 (95% CI 1.20-2.12) for 24-h estimated urinary Na/K ratio and estimated 24-h sodium excretion, respectively. Estimated 24-h potassium excretion was not associated with AF prevalence. CONCLUSIONS: AF prevalence was positively associated with the urinary Na/K ratio and estimated 24-h urinary sodium excretion, but not with estimated 24-h urinary potassium excretion. Although further prospective studies are warranted, the findings of this study suggest that salt intake may be a modifiable risk factor for AF.
Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Aoi Noda, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, M Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Journal of affective disorders　2025/01/10

DOI： 10.1016/j.jad.2025.01.044 　

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BACKGROUND: As multiple Japanese academic societies have recently issued treatment guidelines for perinatal antidepressant treatments, it is considered worthwhile to evaluate the latest trends and continuation of antidepressant medication during pregnancy to optimize antenatal prescriptions. METHODS: The prevalence, trend, and continuation of antidepressant use during pregnancy in Japan from 2012 to 2023 were evaluated, using a large administrative claims database, in women whose pregnancies ended in live births. Annual changes were evaluated using a multivariate logistic regression model adjusted for maternal age at delivery. RESULTS: Of 179,797 women with a mean maternal age at delivery of 32.5 years, 1870 (1.04 %) were prescribed antidepressants during pregnancy. The prevalence significantly increased (P < 0.0001) from 0.63 % in 2012 to 1.67 % in 2023. Antidepressants were prescribed to 1730 women (0.96 %) during the first trimester. Of these, 670 (38.7 %) were antidepressant continuers throughout pregnancy, showing a significant increase (P < 0.0001) from 19.51 % in 2012 to 50.70 % in 2023. The most frequently prescribed class of antidepressants during pregnancy was serotonin reuptake inhibitors (0.74 %), especially sertraline (0.33 %) and escitalopram (0.23 %), with a significant increase in their annual prevalence. LIMITATIONS: Prescriptions for women whose pregnancies ended in abortion or stillbirth could not be evaluated. CONCLUSIONS: Given that antidepressant use and its continuation during pregnancy have become more common, it is important to further disseminate knowledge of the guidelines to healthcare professionals and women of childbearing age, including the promotion of preconception care and shared decision-making.
Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. International-journal

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Takahiro Tabuchi, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Takahito Nasu, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Yoko Izumi, Atsushi Hozawa

BMJ public health　3　(1)　e001746　2025/01

DOI： 10.1136/bmjph-2024-001746 　

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OBJECTIVES: Previous studies have assessed the impact of active smoking on mortality using the population-attributable fraction (PAF). However, these studies have not included second-hand smoking (SHS), potentially underestimating smoking's impact. We compared the PAF from active smoking alone with the PAF, including SHS exposure. DESIGN: Prospective cohort study. SETTING: A community-based cohort study in Japan. PARTICIPANTS: 40 796 participants aged ≥20 years. MAIN OUTCOME MEASURES: SHS was defined as inhaling someone else's cigarette smoke at the workplace or home in the past year. We classified smoking status and SHS into ten categories: never-smoker without SHS, never-smoker with SHS, past smoker without SHS, past smoker with SHS, current smoker 1-9 cigarettes/day without SHS, current smoker 1-9 cigarettes/day with SHS, 10-19 cigarettes/day without SHS, 10-19 cigarettes/day with SHS, ≥20 cigarettes/day without SHS and ≥20 cigarettes/day with SHS. The main outcome was all-cause mortality. RESULTS: During the median follow-up period of 6.5 (5.7-7.5) years, 788 men and 328 women died. For men, compared with never-smokers without SHS, past smokers without SHS (HR, 1.39 [95% CI, 1.11 to 1.73]) and past smokers with SHS (HR, 1.48 (95% CI, 1.10 to 2.00)) were associated with all-cause mortality. For women, never-smokers with SHS had a significantly higher risk of all-cause mortality (HR, 1.36 (95% CI, 1.00 to 1.84)). Without considering SHS, 28.0% and 2.3% of all-cause mortality in men and women, respectively, were attributable to past and current smoking. Including SHS, PAF increased to 31.3% in men and 8.4% in women. CONCLUSIONS: We clarified that smoking's impact was underestimated by not accounting for SHS, especially in women. Information on SHS is crucial for understanding smoking's health impact. This study supports the importance of avoiding smoking and preventing SHS.
Pregnancy and Postpartum Trends in Self-Measured Blood Pressure and Derived Indices: The BOSHI Study. International-journal

Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Journal of clinical hypertension (Greenwich, Conn.)　27　(1)　e14949　2025/01

DOI： 10.1111/jch.14949 　

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In this study, we aimed to reveal the trends of self-measured blood pressure (SMBP) and SMBP-derived indices during pregnancy and the postpartum period. The Babies and Their Parents Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study is a prospective cohort study in Japan. Participants were instructed to measure SMBP daily during pregnancy and for 1 month after delivery. Among 237 participants with normotensive blood pressure (BP) during pregnancy and the postpartum period who were analyzed using mixed-effects models for repeated measures, the SMBP was measured, on average, 14.3 times from the day before delivery to 28 days postpartum. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) on the day before delivery were 110.6 ± 1.0 and 68.1 ± 0.8 mmHg (estimate ± standard error). Postpartum BP increased from postpartum Days 3-8 in SBP and from Days 3-22 in DBP, compared to that on the day before delivery. The SBP and DBP were 4.9 and 4.7 mmHg higher on postpartum Days 8 and 7 than the day before pregnancy, respectively. During pregnancy, the pulse rate (PR) showed an inverted U-shaped trend and then sharply increased rapidly until the first postpartum day after delivery. The Shock Index showed a similar trend to that of the PR, decreased from labor until postpartum Day 8, and plateaued thereafter. The double product peaked during labor, remained higher than the prelabor levels for approximately 10 days, and then decreased in the postpartum period.
Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama

Journal of epidemiology　2024/12/21

DOI： 10.2188/jea.JE20240293 　

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BACKGROUND: The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations, and conducted a self-administered food frequency questionnaire with the response option "constitutionally unable to eat or drink it" for individual food items (TMM-FFQ) for pregnant women. This study evaluated the validity of the TMM-FFQ among pregnant women. METHODS: Participants comprised 122 pregnant women aged ≥20 years residing in Miyagi Prefecture who completed weighed food records (WFRs) for 3 days as reference intake and the TMM-FFQ during mid-pregnancy. Correlations between nutrient or food group intakes based on the WFR and the TMM-FFQ were calculated using Spearman's rank correlation coefficients (CCs), adjusting for energy intake and correcting for random within-individual variation of WFR. Cross-classification was also conducted according to quintiles using the WFR and TMM-FFQ data. RESULTS: The percentages of participants who chose the "constitutionally unable to eat or drink it" option were >3% for seven food and drink items. CCs were >0.30 for 31 nutrients; the median across energy and 44 nutrients was 0.41. CCs were >0.30 for 14 food groups; the median across 20 food groups was 0.35. The median percentages of cross-classification into exact plus adjacent quintiles and extreme quintiles were 63.1% and 3.3% for energy and nutrients and 61.9% and 4.1% for food groups, respectively. CONCLUSIONS: The validity of the TMM-FFQ compared with the WFR was reasonable for certain nutrients and food groups among pregnant women in the TMM BirThree Cohort Study.
Association of Parity with Type 2 Diabetes Mellitus in Japan. International-journal

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

Reproductive sciences (Thousand Oaks, Calif.)　2024/12/11

DOI： 10.1007/s43032-024-01752-z 　

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This study investigates the association between parity and type 2 diabetes mellitus (T2DM) in Japanese women, considering the clinical history of gestational diabetes mellitus (GDM) and menopausal status, which are known risk factors for T2DM. Overall, 30,116 Japanese women (6,588 premenopausal and 23,528 postmenopausal) were included in this cross-sectional study. They were divided into two groups according to menopausal status (premenopausal and postmenopausal women), and the association between parity and T2DM was evaluated using a multiple logistic regression model with possible confounders, including a clinical history of GDM. The association between parity and T2DM was not statistically significant in premenopausal women. In contrast, a linear graded association between parity and T2DM was found in postmenopausal women. Furthermore, the association between parity and T2DM in postmenopausal women was attenuated after adjusting for body weight gain after the age of 20 years. A clinical history of GDM was significantly associated with a high risk for T2DM, regardless of adjustment for body weight gain after the age of 20 years in both premenopausal and postmenopausal women. Parity is associated with an increased risk of T2DM in postmenopausal women but not in premenopausal women. Maintaining appropriate body weight would be beneficial in attenuating the risk of T2DM in postmenopausal women. A clinical history of GDM is a risk factor for T2DM in both pre- and postmenopausal women; therefore, women with a clinical history of GDM require continuous medical care to survey for T2DM.
Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes. International-journal

Keigo Sato, Yoshitaka Nakamura, Kazuhito Fujiyama, Kinuko Ohneda, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Shinji Jinno

Journal of food science　89　(12)　10152-10170　2024/12

DOI： 10.1111/1750-3841.17597 　

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Human milk oligosaccharides (HMOs) have been positively associated with child neurodevelopment in some cohort studies. However, there is a lack of consistency in the association between HMOs and benefits to infants' brains. Moreover, the quantification methods for HMOs have not yet been standardized. In this study, we developed a quantification method for evaluating eight HMOs (2'-fucosyllactose [2'-FL], 3'-fucosyllactose [3'-FL], 3'-sialyllactose [3'-SL], 6'-sialyllactose [6'-SL], lactosialyltetrasaccharide a [LSTa], lactosialyltetrasaccharide b [LSTb], lactosialyltetrasaccharide c [LSTc], and disialyllacto-N-tetraose [DSLNT]) in breast milk. After validating the method, we applied it to 1-month breast milk samples (n = 150) from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study to assess HMO profiles in breast milk and their possible association with changes in head circumference z-score (ΔHCZ) and neurodevelopmental scores of children (as measured by the Ages and Stages Questionnaire, Third Edition). The validation demonstrated that the method had relative standard deviation ≤ 12.7% of precision and 79.5-110.9% of accuracy. Using this method, eight HMO levels (2'-FL, 0-4.74 mg/mL; 3'-FL, 0.02-1.52 mg/mL; 3'-SL, 0.07-0.32 mg/mL; 6'-SL, 0.01-0.70 mg/mL; LSTa, 0.002-0.043 mg/mL; LSTb, 0.02-0.31 mg/mL; LSTc, 0.001-0.47 mg/mL; and DSLNT, 0.09-0.71 mg/mL [min-max, all participants]) and the ratio of low secretors (16.0%) in the Japanese cohort were obtained. The obtained HMO levels in breast milk were subjected to multivariate analysis to screen for HMOs showing a positive association with ΔHCZ and neurodevelopmental scores. The results proposed that ΔHCZ was positively associated with LSTb and 2'-FL levels, whereas neurodevelopmental scores were positively associated with 2'-FL levels (among all participants) and 3'-SL and DSLNT levels (among secretor participants). This study showed that the developed method provides HMO profiles in Japanese breast milk, as well as additional information on the associations between specific HMOs and neurodevelopment, reinforcing the sum of evidence for the role of HMOs in the brain.
Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self-harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Noriyuki Iwama, Ippei Chiba, Kumi Nakaya, Rieko Hatanaka, Mana Kogure, Natsuko Kobayashi, Saya Kikuchi, Hirohito Metoki, Masahiro Kikuya, Naoki Nakaya, Atsushi Hozawa, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(4)　e70025　2024/12

DOI： 10.1002/pcn5.70025 　

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AIM: The aim of this study was to evaluate depression at 6 and 12 months postpartum, using the Edinburgh Postpartum Depression Scale (EPDS) total score and its subitem regarding self-harm ideation (SHI) at 1 month postpartum. METHODS: A sample of 12,358 postpartum women answered the EPDS and questionaries at 1, 6, and 12 months postpartum longitudinally. RESULTS: For participants with postpartum depression (PPD; EPDS total score ≥9) and SHI (SHI sub-score ≥1) at 1 month postpartum, the risk of depression at 6 and 12 months postpartum (odds ratio [95% confidence interval] at 6 and 12 months postpartum: 20.03 [16.8-23.8] and 14.55 [12.3-17.2], respectively) was higher than for those with PPD but without SHI at 1 month postpartum (OR: 8.57 [7.36-10.0], and 6.24 [5.38-7.24], respectively). Additionally, SHI even without depressive symptoms at 1 month postpartum is also a risk for depression at 6 and 12 months postpartum. To support our longitudinal evaluation of depression at 6 and 12 months postpartum, these related factors were examined: traumatic events or relocations after the Great East Japan Earthquake, employment status, household income, personality traits, sleep status, psychological distress, and social networks. The result showed employment status, low household income and poor social networks were significantly associated with depression at 12 months postpartum but not at 6 months postpartum. CONCLUSION: This study showed a high risk of depression at 6 and 12 months postpartum for those who had depressive symptoms with SHI at 1 month postpartum. Our findings may contribute to the precise evaluation of depression at 6 and 12 months postpartum while considering sleep status, psychological distress and social network during pregnancy.
Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. International-journal

Satoshi Mizuno, Satoshi Nagaie, Junichi Sugawara, Gen Tamiya, Taku Obara, Mami Ishikuro, Shinichi Kuriyama, Nobuo Yaegashi, Hiroshi Tanaka, Masayuki Yamamoto, Soichi Ogishima

AJOG global reports　4　(4)　100383-100383　2024/11

DOI： 10.1016/j.xagr.2024.100383 　

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BACKGROUND: Various disease prediction models have been developed, capitalizing on the wide use of electronic health records, but environmental factors that are important in the development of noncommunicable diseases are rarely included in the prediction models. Hypertensive disorders of pregnancy are leading causes of maternal morbidity and mortality and are known to cause several serious complications later in life. OBJECTIVE: This study aims to develop early hypertensive disorders of pregnancy prediction models using comprehensive environmental factors based on self-report questionnaires in early pregnancy. STUDY DESIGN: We developed machine learning and artificial intelligence models for the early prediction of hypertensive disorders of pregnancy using early pregnancy data from approximately 23,000 pregnancies in the Tohoku Medical Megabank Birth and Three Generation Cohort Study. We clarified the important features for prediction based on regression coefficients or Gini coefficients of the interpretable artificial intelligence models (i.e., logistic regression, random forest and XGBoost models) among our developed models. RESULTS: The performance of the early hypertensive disorders of pregnancy prediction models reached an area under the receiver operating characteristic curve of 0.93, demonstrating that the early hypertensive disorders of pregnancy prediction models developed in this study retain sufficient performance in hypertensive disorders of pregnancy prediction. Among the early prediction models, the best performing model was based on self-reported questionnaire data in early pregnancy (mean of 20.2 gestational weeks at filling) which consist of comprehensive lifestyles. The interpretation of the models reveals that both eating habits were dominantly important for prediction. CONCLUSION: We have developed high-performance models for early hypertensive disorders of pregnancy prediction using large-scale cohort data from the Tohoku Medical Megabank project. Our study clearly revealed that the use of comprehensive lifestyles from self-report questionnaires led us to predict hypertensive disorders of pregnancy risk at the early stages of pregnancy, which will aid early intervention to reduce the risk of hypertensive disorders of pregnancy.
Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Chikana Kawaguchi, Maki Ozawa, Takanori Hidaka, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Masatsugu Orui, Taku Obara, Yumiko Ito, Takashi Kakinuma, Kazuhiro Kudoh, Hiroaki Ozawa, Satoshi Nakagawa, Masato Mizuashi, Ryoko Omori, Masatoshi Deguchi, Yumi Kanbayashi, Masayuki Asano, Toshiya Takahashi, Muneo Tanita, Masahiro Hara, Kenshi Yamasaki, Takayoshi Tadaki, Hiromi Suzuki, Katsuko Kikuchi, Kenichiro Tsuchiyama, Takenobu Ohashi, Shu Sasai, Motoko Honda, Taku Fujimura, Sadanori Furudate, Yoshiko Kagimoto, Maki Kawamura, Nobuko Tabata, Rika Chikama, Hiromi Komatsu, Yota Sato, Kayo Tanita, Yutaka Kimura, Shino Yusa, Hitoshi Terui, Hisayuki Tono, Yusuke Muto, Shinichi Kuriyama, Masayuki Yamamoto, Setsuya Aiba

Allergology international : official journal of the Japanese Society of Allergology　2024/10/18

DOI： 10.1016/j.alit.2024.09.008 　

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BACKGROUND: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey. METHODS: This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists' diagnoses. RESULTS: Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75-0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively. CONCLUSIONS: Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.
Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Mami Ishikuro, Taku Obara, Mayu Hasegawa, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Noriyuki Iwama, Masahiro Kikuya, Junichi Sugawara, Tatsuhiko Azegami, Takashin Nakayama, Asako Mito, Naoko Arata, Hirohito Metoki, Takeshi Kanda, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　2024/10/11

DOI： 10.1038/s41440-024-01936-9 　

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Hypertensive disorders of pregnancy can cause hypertension in the future. Understanding how the blood pressure values of women with and without hypertensive disorders of pregnancy differ will facilitate follow-up blood pressure monitoring in clinical settings. This study investigated the association between hypertensive disorders of pregnancy and subsequent high blood pressure and hypertension. This study used Japanese data from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Follow-up systolic and diastolic blood pressures in normotensive women during pregnancy and those with hypertensive disorders of pregnancy were estimated using analysis of covariance adjusted for women with low birthweight, history of gestational diabetes mellitus, age, body mass index, pulse rate, smoking and drinking at the follow-up assessment, paternal hypertension history, and maternal hypertension or hypertensive disorders of pregnancy history. Finally, we performed a multiple logistic regression analysis. In total, 7343 women were included in the analysis. Women with a history of hypertensive disorders of pregnancy had higher blood pressure approximately three years postpartum compared with normotensive women. Hypertensive disorders of pregnancy in the most recent pregnancy in different subgroups, such as nulliparous women, multiparous women without a history of hypertensive disorders of pregnancy, and multiparous women with a history of hypertensive disorders of pregnancy, were associated with an increased risk of subsequent hypertension. Women's birthweight was also weakly associated with hypertension. Even one experience of hypertensive disorders of pregnancy may contribute to elevated blood pressure and hypertension approximately three years postpartum. In addition, women's birthweights may have a weak relationship with increasing blood pressure.
Identification of risk loci for postpartum depression in a genome-wide association study. International-journal

Xue Li, Nagahide Takahashi, Akira Narita, Yukako Nakamura, Mika Sakurai-Yageta, Keiko Murakami, Mami Ishikuro, Taku Obara, Masahiro Kikuya, Fumihiko Ueno, Hirohito Metoki, Hisashi Ohseto, Ippei Takahashi, Tomohiro Nakamura, Noriko Warita, Tomoka Shoji, Zhiqian Yu, Chiaki Ono, Natsuko Kobayashi, Saya Kikuchi, Tasuku Matsuki, Fuji Nagami, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Norio Ozaki, Gen Tamiya, Shinichi Kuriyama, Hiroaki Tomita

Psychiatry and clinical neurosciences　2024/09/17

DOI： 10.1111/pcn.13731 　

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AIM: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci. METHODS: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. RESULTS: A meta-analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10-8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. CONCLUSION: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis.
Genetic Risk, Lifestyle Adherence, and Risk of Developing Hyperuricaemia in a Japanese Population. International-journal

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Biobank Japan Project Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Rheumatology (Oxford, England)　2024/09/13
Publisher: Oxford University Press (OUP)
DOI： 10.1093/rheumatology/keae492 　

ISSN： 1462-0324

eISSN： 1462-0332

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Abstract Objective To investigate the inter-relationships among genetic risk, healthy lifestyle adherence, and hyperuricaemia susceptibility. Methods This prospective cohort study was conducted with 7,241 hyperuricaemia-free individuals aged ≥ 20 years from the Tohoku Medical Megabank Community-based cohort study. A comprehensive lifestyle score included body mass index, smoking, drinking, and physical activity, and a polygenic risk score (PRS) was constructed based on uric acid loci from a previous genome-wide association study meta-analysis. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and hyperuricaemia incidence and calculate the area under the receiver operating characteristic curve (AUROC). Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dl or a self-reported history of hyperuricaemia. Results Of the 7,241 adults (80.7% females; mean [SD] age: 57.7 [12.6] years), 217 (3.0%) developed hyperuricaemia during 3.5 years of follow-up. Genetic risk correlated with hyperuricaemia development (P for interaction = 0.287), and lifestyle risks were independently associated. Those with a high genetic risk and poor lifestyle had the highest risk (odds ratio: 5.34; 95% confidence interval [CI]: 2.61–12.10). Although not statistically significant, incorporating the PRS in the model with lifestyle information improved predictive ability (AUROC = 0.771, 95% CI: 0.736–0.806 for lifestyle; AUROC = 0.785, 95% CI: 0.751–0.819 for lifestyle and PRS; p = 0.07). Conclusion : A healthy lifestyle to prevent hyperuricaemia, irrespective of genetic risk, may mitigate the genetic risk. Genetic risk may complement lifestyle factors in identifying individuals at a heightened hyperuricaemia risk.
Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. International-journal

Tomofumi Ishikawa, Takamasa Sakai, Noriyuki Iwama, Ryo Obara, Kei Morishita, Motohiko Adomi, Aoi Noda, Mami Ishikuro, Saya Kikuchi, Natsuko Kobayashi, Hiroaki Tomita, Masatoshi Saito, Hidekazu Nishigori, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Acta psychiatrica Scandinavica　2024/09/05

DOI： 10.1111/acps.13755 　

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OBJECTIVE: To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. MATERIAL AND METHODS: This nested case-control study used a large Japanese administrative database. Pregnancy onset and outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant between 2013 and 2022 and ending in a miscarriage. Controls were randomly selected from the entire pregnancy cohort by risk-set sampling with replacement and were individually matched to the cases (3:1). The association between exposure to atypical antipsychotics and risk of miscarriage was assessed using conditional logistic regression adjusted for confounders. The association between benzodiazepine exposure and the risk of miscarriage was assessed as a positive control. RESULTS: In the cohort, 44,118 patients were matched with 132,317 controls. The mean ages (standard deviations) of the case and control groups were 33.3 (5.7) and 33.2 (5.5) years, respectively. The prevalence of atypical antipsychotics was 0.5% in both groups. Aripiprazole is an individual antipsychotic with the highest prescription prevalence. The adjusted odds ratios (aOR) for miscarriage were 0.966 (95% confidence interval [CI], 0.796-1.173) for atypical antipsychotics and 0.998 (0.784-1.269) for aripiprazole. A higher aOR (1.431, 95% CI 1.303-1.573) suggested an association with benzodiazepines. A sensitivity analysis that limited the population to women diagnosed with schizophrenia alone did not suggest an association between atypical antipsychotics and the risk of miscarriage. CONCLUSIONS: The results of this study do not suggest an association between exposure to atypical antipsychotics during pregnancy and the risk of miscarriage.
Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Ippei Takahashi, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Ryo Obara, Aoi Noda, Minoru Ohsawa, Tomofumi Ishikawa, Nariyasu Mano, Hidekazu Nishigori, Fumihiko Ueno, Genki Shinoda, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Shinichi Kuriyama

PCN reports : psychiatry and clinical neurosciences　3　(3)　e226　2024/09

DOI： 10.1002/pcn5.226 　

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AIM: To examine the association of the combination of taking neuropsychiatric medications from the onset of pregnancy to mid-pregnancy and maternal psychological distress at mid-pregnancy, with children's behavioral problems. METHODS: Neuropsychiatric medication use from the onset of pregnancy to mid-pregnancy was defined by the self-reported name of the neuropsychiatric medication in the questionnaire in early and mid-pregnancy. Maternal psychological distress was defined by the Kessler Psychological Distress Scale (K6) ≥13 on the questionnaire in mid-pregnancy. We classified the participants into four categories based on the combination of taking neuropsychiatric medications and psychological distress: "None," "Medications only," "K6 ≥ 13 only," and "Both." Children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) at 2 years of age. The clinical ranges of the internalizing and externalizing scales of the CBCL were defined as behavioral problems. We conducted a multivariable logistic regression analysis to examine the associations between the four categories of maternal exposure and children's behavioral problems. RESULTS: Compared with the "None" category (n = 9873), the "K6 ≥ 13 only" category (n = 308) was statistically significantly associated with internalizing and externalizing problems. In contrast, the "Medications only" (n = 93) and "Both" (n = 22) categories were not statistically significantly associated with internalizing and externalizing problems, although the point estimates of the odds ratio in the "Both" category were relatively high (1.58 for the internalizing problem and 2.50 for the externalizing problem). CONCLUSION: The category of mothers taking neuropsychiatric medications and having no psychological distress during pregnancy was not associated with children's behavioral problems in the present population.
Genome-wide association study based on clustering by obesity-related variables uncovers a genetic architecture of obesity in the Japanese and the UK populations. International-journal

Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Oonuma, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Atsushi Hozawa, Junichi Sugawara, Gen Tamiya, Shinichi Kuriyama

Heliyon　10　(16)　e36023　2024/08/30

DOI： 10.1016/j.heliyon.2024.e36023 　

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Whether all obesity-related variants contribute to the onset of obesity or one or a few variants cause obesity in genetically heterogeneous populations remains obscure. Here, we investigated the genetic architecture of obesity by clustering the Japanese and British populations with obesity using obesity-related factors. In Step-1, we conducted a genome-wide association study (GWAS) with body mass index (BMI) as the outcome for eligible participants. In Step-2, we assigned participants with obesity (BMI ≥25 kg/m2) to five clusters based on obesity-related factors. Subsequently, participants from each cluster and those with a BMI <25 kg/m2 were combined. A GWAS was conducted for each cluster. Several previously identified obesity-related genes were verified in Step-1. Of the genes detected in Step-1, unique obesity-related genes were detected separately for each cluster in Step-2. Our novel findings suggest that a smaller sample size with increased homogeneity may provide insights into the genetic architecture of obesity.
Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study. International-journal

Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

Scientific reports　14　(1)　19138-19138　2024/08/19

DOI： 10.1038/s41598-024-69726-4 　

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Few population-based studies including younger adults have examined the potential of olfactory function tests to capture the degree of atrophy in memory-associated brain regions, which cannot be adequately explained by cognitive function tests screening for cognitive impairment. This population-based study investigated associations between high-resolution olfactory test data with few odours and grey matter volumes (GMVs) of the left and right hippocampi, amygdala, parahippocampi, and olfactory cortex, while accounting for differences in cognitive decline, in 1444 participants (aged 31-91 years). Regression analyses included intracranial volume (ICV)-normalised GMVs of eight memory-related regions as objective variables and age, sex, education duration, smoking history, olfaction test score, and the Montreal Cognitive Assessment-Japanese version (MoCA-J) score as explanatory variables. Significant relationships were found between olfactory test scores and ICV-normalised GMVs of the left and right hippocampi and left amygdala (p = 0.020, 0.024, and 0.028, respectively), adjusting for the MoCA-J score. The olfactory test score was significantly related to the right amygdalar GMV (p = 0.020) in older adults (age ≥ 65 years). These associations remained significant after applying Benjamini-Hochberg multiple testing correction (false discovery rate < 0.1). Therefore, olfactory and cognitive function tests may efficiently capture the degree of atrophy in the hippocampi and amygdala, especially in older adults.
Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study. International-journal

Takuma Usuzaki, Mami Ishikuro, Masahiro Kikuya, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Scientific reports　14　(1)　19047-19047　2024/08/16

DOI： 10.1038/s41598-024-69752-2 　

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To examine child-parent associations of HCT among Japanese adults and their parents. Factors associated with hematocrit (HCT) were analyzed in 3,574 sons and 7,203 daughters using Pearson's correlation coefficient and Student's t-test. Multiple linear regression analysis, adjusted by the factors identified by univariate analyses and by living with parents, was performed on 242 son-parent trios and 587 daughter-parent trios. When a child-parent association was observed in the multiple linear regression analysis, it was validated using the random family method (RFM). In univariate analyses, the son's HCT was associated with age (correlation coefficient = -0.072), white blood cell (WBC) (0.19), alanine aminotransferase (ALT) (0.20), triglyceride (0.11), and estimated glomerular filtration rate (eGFR) (- 0.087). The daughter's HCT was associated with WBC (0.014), ALT (0.18), and eGFR (- 0.17). In multiple linear regression analysis, the son's HCT was associated with the son's WBC (coefficient = 3.48 × 10-4), the son's eGFR (0.031), the father's HCT (0.11), and the mother's HCT (0.17). RFM confirmed the association between the son's and father's HCT (p = 0.0070) and between the son's and mother's HCT (p = 0.0011). The daughter's HCT was associated with WBC (2.6 × 10-4), ALT (0.037), and the mother's HCT (0.14). RFM confirmed the association between the daughter's and mother's HCT (p = 0.00043). Child-parent association of HCT was confirmed between son-father, son-mother, and daughter-mother relationships, and differed depending on the sex of the child and the parents.
The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. International-journal

Hiromi Himuro, Mana Kogure, Naoki Nakaya, Tomohiro Nakamura, Rieko Hatanaka, Ippei Chiba, Kumi Nakaya, Naho Tsuchiya, Takumi Hirata, Masatsugu Orui, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Akira Uruno, Nobuo Fuse, Satoshi Nagaie, Soichi Ogishima, Mami Ishikuro, Taku Obara, Yoko Izumi, Masatoshi Saito, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　2024/08/08

DOI： 10.1038/s41440-024-01827-z 　

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This study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20-64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04-3.65) compared to the reference group (birth weight 2500-3499 g and BMI 18.5-24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.
Validity and reproducibility of food group intakes in a self-administered food frequency questionnaire for genomic and omics research: the Tohoku Medical Megabank Project.

Keiko Murakami, Junko Ishihara, Ribeka Takachi, Shiori Sugawara, Misato Aizawa, Ippei Takahashi, Taku Obara, Mami Ishikuro, Aoi Noda, Mako Ogino, Yuchie Hoshina, Kumiko Kito, Misako Nakadate, Sachiko Maruya, Tomoka Matsuno, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Masayuki Yamamoto, Shinichi Kuriyama

Journal of epidemiology　2024/08/03

DOI： 10.2188/jea.JE20240064 　

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BACKGROUND: The Tohoku Medical Megabank Project (TMM) was established to realize personalized healthcare and medicine using genomic and omics data. This study evaluated the validity and reproducibility of food group intakes derived from a self-administered food frequency questionnaire (TMM-FFQ) that included the response option "constitutionally unable to eat/drink it" among community-dwelling Japanese adults. METHODS: Participants comprised 89 men and 124 women aged ≥20 years from Miyagi Prefecture. Participants completed weighed food records (WFRs) for 3 consecutive days per season as reference intake and FFQs in 2019 (FFQ1) and 2021 (FFQ3). Spearman's rank correlation coefficients (CCs) were calculated for correlations between food group intakes estimated from the 12-day WFR and FFQ3 (validity), and for correlations between those estimated from the FFQ1 and FFQ3 (reproducibility). Cross-classification according to quintiles using FFQ and WFR data was also performed. RESULTS: The percentage of participants who chose the "constitutionally unable to eat/drink it" option was non-negligible for some food groups. In the validity analysis, CCs were >0.40 for many food groups; the median across 21 food groups was 0.49 in men and 0.45 in women. The median percentages of cross-classification into exact plus adjacent quintiles were 73.0% in men and 66.9% in women. In the reproducibility analysis, CCs were >0.50 for many food groups; the median across 21 food groups was 0.60 in men and 0.51 in women. CONCLUSIONS: The validity of the TMM-FFQ compared with 12-day WFR and the reproducibility of the TMM-FFQ were reasonable for food groups in the TMM cohort studies.
Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation. International-journal

Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, Mana Kogure, Naoki Nakaya, Naoya Fujino, Tsutomu Tamada, Chikashi Iwasaki, Manami Suzuki, Shuichiro Matsumoto, Nobuo Fuse, Akira Uruno, Kazuki Kumada, Soichi Ogishima, Shinichi Kuriyama, Masakazu Ichinose, Hisatoshi Sugiura, Atsushi Hozawa

The journal of allergy and clinical immunology. Global　3　(3)　100253-100253　2024/08

DOI： 10.1016/j.jacig.2024.100253 　

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BACKGROUND: Measurement of fractional exhaled nitric oxide (Feno) has been used in the diagnosis and management of asthma. Understanding the distribution of Feno in a larger resident population and its "healthy" subpopulation would contribute to the interpretation of Feno in clinical practice. OBJECTIVE: This study aimed to investigate the distribution and its associated factors in the adult population and its healthy subpopulations. METHODS: We conducted a cross-sectional study of 8,638 men and 17,288 women aged 20 years or older living in Miyagi prefecture, Japan. We investigated the distribution of Feno and its associated factors in all subjects, a subpopulation with no history of upper and lower airway diseases (healthy subpopulation 1), and a subpopulation with no history of upper and lower airway diseases, normal lung function, and no positivity for other biomarkers of type 2 inflammation (healthy subpopulation 2). RESULTS: The distribution of Feno in healthy subpopulations, especially in healthy subpopulation 2 (median [interquartile range], 17 [12-23] with 95th percentile of 36 ppb) was lower than in all subjects (19 [13-26] ppb with 95th percentile of 47 ppb). In healthy subpopulation 1, 10.3% had elevated Feno (≥35 ppb), and elevated Feno was positively associated with factors including obstructive ventilatory defect, blood eosinophilia, house dust mite-specific IgE positivity, and history of hypertension. Male sex was associated with elevated Feno in all subjects and healthy subpopulations. CONCLUSION: The distribution of Feno in the healthy subpopulation supports the validity of the criteria (≥35 ppb) currently used in Japan for the diagnosis of asthma.
Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study.

Seiya Izumi, Noriyuki Iwama, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Michihiro Satoh, Takahisa Murakami, Masatoshi Saito, Takayoshi Ohkubo, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Endocrine journal　2024/07/26

DOI： 10.1507/endocrj.EJ23-0568 　

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This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87-125 mg/dL) and HbA1c (5.2-6.3% [33-45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002-1.775) for Q4 of FPG and 1.405 (95% CI: 1.051-1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000-1.496) and 1.392 (95% CI: 1.122-1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels.
How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Masatsugu Orui, Taku Obara, Mami Ishikuro, Aoi Noda, Genki Shinoda, Keiko Murakami, Tomohiro Nakamura, Hirohito Metoki, Soichi Ogishima, Yoko Izumi, Naoki Nakaya, Atsushi Hozawa, Tadashi Ishii, Fuji Nagami, Masayuki Yamamoto, Shinichi Kuriyama

JMA journal　7　(3)　353-363　2024/07/16

DOI： 10.31662/jmaj.2024-0043 　

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INTRODUCTION: To examine the interaction between lifestyle habits and the COVID-19 vaccinations for preventing SARS-CoV-2 infection, we analyzed 11,016 adult participants registered in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. METHODS: Lifestyle variables, including regular exercise, smoking and drinking habits, sleep status, body mass index, and daily breakfast consumption, were assessed from 2014 to 2019 using baseline questionnaires. Information on SARS-CoV-2 infection and the COVID-19 vaccination were also collected from March 2020 to May 2023. The study period was divided into two in the postvaccination phase: the first period (the beginning of the vaccination program) and the second period (the fourth shot onward). RESULTS: In the Cox proportional-hazards model analysis, the five-time vaccinations group showed a significantly lower risk of SARS-CoV-2 infection adjusted age, sex, underlying health condition, and lifestyle variables (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.76-0.86). Logistic regression analysis revealed that a higher number of vaccinations was significantly associated with a low risk of SARS-CoV-2 infection regardless of lifestyle habits (three times in the first period: odds ratio [OR] 0.19, 95% CI 0.15-0.24; five times in the second period: OR 0.07, 95% CI 0.05-0.11 vs. none). Regarding lifestyle habits, the risk reduction in those who had sleep satisfaction (OR 0.12, 95% CI 0.08-0.18) was slightly larger than in those who had sleep dissatisfaction (OR 0.23, 95% CI 0.17-0.32) in the group with the highest number of vaccinations in the first period; however, this interaction was hardly confirmed in the second period when the number of infected cases significantly increased. CONCLUSIONS: Our findings indicated that a higher number of COVID-19 vaccinations was associated with reduced risk of SARS-CoV-2 infection; otherwise, we may need to understand the advantages and limitations of a healthy lifestyle for preventing infection depending on the situation with vaccinations and infection spreading.
Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project.

Eiichi N Kodama, Makiko Taira, Hideyasu Kiyomoto, Tomohiro Nakamura, Satoshi Nagaie, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara, Fuji Nagami, Akira Uruno, Jun Nakaya, Hirohito Metoki, Masaki Sakaida, Masahiro Kikuya, Yoichi Suzuki, Kiyoshi Ito, Yohei Hamanaka, Kichiya Suzuki, Shigeo Kure, Nobuo Yaegashi, Nobuo Fuse, Ritsuko Shimizu, Masayuki Yamamoto

JMA journal　7　(3)　342-352　2024/07/16

DOI： 10.31662/jmaj.2023-0215 　

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INTRODUCTION: The Tohoku Medical Megabank (TMM) was established for creative reconstruction from the Great East Japan Earthquake and tsunami in 2011. Two prospective genome cohort studies in Miyagi prefecture have successfully recruited approximately 127,000 participants. The health status of these individuals was evaluated at the initial recruitment, and follow-up health checkups have been conducted every 5 years. During these health checkups, unexpected critical values were encountered, which prompted us to develop an urgent notification system. METHODS: We analyzed the frequency of critical values observed in home blood pressure (HBP) test in an urgent notification office (UNO). We returned the critical values by urgent notification before the notifications of regular results. In addition, the impact of the TMM urgent notification on the participants was evaluated. RESULTS: We issued urgent notifications of the critical values of extremely high HBP. Of the 21,061 participants who underwent HBP measurements, 256 (1.2%) met the criteria for urgent notification. It was found that abnormalities in blood sugar levels, renal function, and lipid values were frequently concurrent with the abnormal HBP readings. Annual questionnaires administered after the urgent notification, approximately 60% of those went to hospitals or clinics. CONCLUSIONS: The urgent notification system for hypertensive emergency with HBP in the TMM was well accepted by the participants and encouraged them to seek medical care. The system has been useful in addressing the prolonged healthcare problems and in promoting health care in large-scale disaster damaged areas.
Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. International-journal

Sayuri Tokioka, Naoki Nakaya, Rieko Hatanaka, Kumi Nakaya, Mana Kogure, Ippei Chiba, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2024/07/10

DOI： 10.1038/s41440-024-01790-9 　

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Depression is comorbid with somatic diseases; however, the relationship between depressive symptoms and hypertension (HT), a risk factor for cardiovascular events, remains unclear. Home blood pressure (BP) is more reproducible and accurately predictive of cardiovascular diseases than office BP. Therefore, we focused on home BP and investigated whether depressive symptoms contributed to the future onset of home HT. This prospective cohort study used data from the Tohoku Medical Megabank Community-Cohort Study (conducted in the Miyagi Prefecture, Japan) and included participants with home normotension (systolic blood pressure (SBP) < 135 mmHg and diastolic blood pressure (DBP) < 85 mmHg). Depressive symptoms were evaluated using the Center for Epidemiologic Studies Depression Scale-Japanese version at the baseline survey. In the secondary survey, approximately 4 years later, the onset of home HT was evaluated (SBP ≥ 135 mmHg or DBP ≥ 85 mmHg) and was compared in participants with and without depressive symptoms. Of the 3 082 (mean age: 54.2 years; females: 80.9%) participants, 729 (23.7%) had depressive symptoms at the baseline survey. During the 3.5-year follow-up, 124 (17.0%) and 388 (16.5%) participants with and without depressive symptoms, respectively, developed home HT. Multivariable adjusted odds ratios were 1.37 (95% confidence interval (CI): 1.02-1.84), 1.18 (95% CI: 0.86-1.61), and 1.66 (95% CI: 1.17-2.36) for home, morning, and evening HT, respectively. This relationship was consistent in the subgroup analyses according to age, sex, BP pattern, and drinking habit. Depressive symptoms increased the risk of new-onset home HT, particularly evening HT, among individuals with home normotension. This prospective cohort study revealed that depressive symptoms are risk factors for new-onset home hypertension, particularly evening hypertension among individuals with home normotension. Assessing home blood pressure in individuals with depressive symptoms is important for the prevention of hypertension and concomitant cardiovascular diseases.
Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. International-journal

Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, Kazuki Kumada, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Scientific reports　14　(1)　15681-15681　2024/07/08

DOI： 10.1038/s41598-024-66180-0 　

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Understanding the physiological changes associated with aging and the associated disease risks is essential to establish biomarkers as indicators of biological aging. This study used the NMR-measured plasma metabolome to calculate age-specific metabolite indices. In doing so, the scope of the study was deliberately simplified to capture general trends and insights into age-related changes in metabolic patterns. In addition, changes in metabolite concentrations with age were examined in detail, with the period from 55-59 to 60-64 years being a period of significant metabolic change, particularly in men, and from 45-49 to 50-54 years in females. These results illustrate the different variations in metabolite concentrations by sex and provide new insights into the relationship between age and metabolic diseases.
Associations of combined genetic and lifestyle risks with hypertension and home hypertension. International-journal

Masato Takase, Takumi Hirata, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Akira Narita, Hirohito Metoki, Michihiro Satoh, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Hypertension research : official journal of the Japanese Society of Hypertension　2024/06/24

DOI： 10.1038/s41440-024-01705-8 　

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No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic and lifestyle risks with home hypertension. We examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. In a cross-sectional study of 7027 Japanese individuals aged ≥20 years, we developed a lifestyle score based on body mass index, alcohol consumption, physical activity, and sodium-to-potassium ratio, categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score was constructed with the target data (n = 1405) using publicly available genome-wide association study summary statistics from BioBank Japan. Using the test data (n = 5622), we evaluated polygenic risk score performance and examined the associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension and home hypertension were defined as blood pressure measured at a community-support center ≥140/90 mmHg or at home ≥135/85 mmHg, respectively, or self-reported treatment for hypertension. In the test data, 2294 and 2322 participants had hypertension and home hypertension, respectively. Both polygenic risk and lifestyle scores were independently associated with hypertension and home hypertension. Compared with those of participants with low genetic risk and an ideal lifestyle, the odds ratios for hypertension and home hypertension in the low genetic risk and poor lifestyle group were 1.94 (95% confidence interval, 1.34-2.80) and 2.15 (1.60-2.90), respectively. In summary, lifestyle is important to prevent hypertension; nevertheless, participants with high genetic risk should carefully monitor their blood pressure despite a healthy lifestyle.
Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kengo Kinoshita, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2024/06/22

DOI： 10.5551/jat.64906 　

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AIM: This study examined the relationship between genetic risk, healthy lifestyle, and risk of developing diabetes. METHODS: This prospective cohort study included 11,014 diabetes-free individuals ≥ 20 years old from the Tohoku Medical Megabank Community-based cohort study. Lifestyle scores, including the body mass index, smoking, physical activity, and gamma-glutamyl transferase (marker of alcohol consumption), were assigned, and participants were categorized into ideal, intermediate, and poor lifestyles. A polygenic risk score (PRS) was constructed based on the type 2 diabetes loci from the BioBank Japan study. A multiple logistic regression model was used to estimate the association between genetic risk, healthy lifestyle, and diabetes incidence and to calculate the area under the receiver operating characteristic curve (AUROC). RESULT: Of the 11,014 adults included (67.8% women; mean age [standard deviation], 59.1 [11.3] years old), 297 (2.7%) developed diabetes during a mean 4.3 (0.8) years of follow-up. Genetic and lifestyle score is independently associated with the development of diabetes. Compared with the low genetic risk and ideal lifestyle groups, the odds ratio was 3.31 for the low genetic risk and poor lifestyle group. When the PRS was integrated into a model including the lifestyle and family history, the AUROC significantly improved to 0.719 (95% confidence interval [95% CI]: 0.692-0.747) compared to a model including only the lifestyle and family history (0.703 [95% CI, 0.674-0.732]). CONCLUSION: Our findings indicate that adherence to a healthy lifestyle is important for preventing diabetes, regardless of genetic risk. In addition, genetic risk might provide information beyond lifestyle and family history to stratify individuals at high risk of developing diabetes.
Maternal birth weight is an indicator of preterm delivery: The Japan environment and children's study

Rie Kudo, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Journal of Developmental Origins of Health and Disease　15　2024/05/22

DOI： 10.1017/S2040174424000126 　

ISSN： 2040-1744

eISSN： 2040-1752
Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index. International-journal

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

BMC nephrology　25　(1)　166-166　2024/05/17

DOI： 10.1186/s12882-024-03604-z 　

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BACKGROUND: Global studies exploring the relationship between parity and chronic kidney disease (CKD) are scarce. Furthermore, no study has examined the relationship between parity and CKD in Japan. Therefore, this study aimed to examine the relationship between parity and the prevalence of CKD in a Japanese population, considering the clinical history of hypertensive disorders of pregnancy (HDP) and current body mass index (BMI) based on menopausal status. METHODS: This cross-sectional study included 26,945 Japanese multiparous women (5,006 premenopausal and 21,939 postmenopausal women) and 3,247 nulliparous women (1,599 premenopausal and 1,648 postmenopausal women). Participants were divided into two groups based on their menopausal status (premenopausal and postmenopausal women). The relationship between parity and the prevalence of CKD was evaluated using a multiple logistic regression model adjusted for several covariates, including a clinical history of HDP and current BMI. RESULTS: The relationship between parity and the prevalence of CKD was not statistically significant in either premenopausal or postmenopausal multiparous women. A clinical history of HDP was significantly associated with an increased risk of CKD in premenopausal and postmenopausal multiparous women. However, the relationship between a clinical history of HDP and CKD in premenopausal women was weakened after adjusting for current BMI. Furthermore, the current BMI was significantly associated with an increased risk of CKD in both premenopausal and postmenopausal women. CONCLUSIONS: Parity is not significantly associated with the prevalence of CKD in premenopausal and postmenopausal multiparous women. A clinical history of HDP is a risk factor for CKD in both premenopausal and postmenopausal women. Current BMI is also associated with an increased risk of CKD in premenopausal and postmenopausal women. Therefore, continuous surveillance and preventive measures against CKD should be provided to women with a clinical history of HDP. In addition, maintaining an appropriate body weight is beneficial in reducing the risk of CKD.
A fine-scale genetic map of the Japanese population. International-journal

Jun Takayama, Satoshi Makino, Takamitsu Funayama, Masao Ueki, Akira Narita, Keiko Murakami, Masatsugu Orui, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Masayuki Yamamoto, Gen Tamiya

Clinical genetics　2024/05/08

DOI： 10.1111/cge.14536 　

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Genetic maps are fundamental resources for linkage and association studies. A fine-scale genetic map can be constructed by inferring historical recombination events from the genome-wide structure of linkage disequilibrium-a non-random association of alleles among loci-by using population-scale sequencing data. We constructed a fine-scale genetic map and identified recombination hotspots from 10 092 551 bi-allelic high-quality autosomal markers segregating among 150 unrelated Japanese individuals whose genotypes were determined by high-coverage (30×) whole-genome sequencing, and the genotype quality was carefully controlled by using their parents' and offspring's genotypes. The pedigree information was also utilized for haplotype phasing. The resulting genome-wide recombination rate profiles were concordant with those of the worldwide population on a broad scale, and the resolution was much improved. We identified 9487 recombination hotspots and confirmed the enrichment of previously known motifs in the hotspots. Moreover, we demonstrated that the Japanese genetic map improved the haplotype phasing and genotype imputation accuracy for the Japanese population. The construction of a population-specific genetic map will help make genetics research more accurate.
Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community-based cohort study.

Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Nobuo Fuse, Taku Obara, Yuka Kotozaki, Kozo Tanno, Shinichi Kuriyama, Atsushi Hozawa

Geriatrics & gerontology international　2024/05/03

DOI： 10.1111/ggi.14867 　

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AIM: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. METHODS: This cross-sectional study enrolled 29 039 community-dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster-related damage (by complete or not complete housing damage) and psychological damage (by post-traumatic stress reaction [PTSR]) after the GEJE using a self-report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster-related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. RESULTS: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19-0.27) and PTSR (β = 0.60; 95% CI: 0.53-0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. CONCLUSIONS: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; ••: ••-••.
The association between blood pressure control in women during pregnancy and adverse perinatal outcomes: the TMM BirThree Cohort Study. International-journal

Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　47　(5)　1216-1222　2024/05

DOI： 10.1038/s41440-023-01570-x 　

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Blood pressure (BP) control in pregnancy is essential to prevent adverse outcomes. However, BP levels for hypertension treatment are inconsistent among various guidelines. This study investigated the association between BP control and adverse perinatal outcomes. A total of 18,155 mother-offspring pairs were classified into four groups according to BP after 20 gestational weeks: normal BP (<140/90 mmHg without antihypertensive drugs), high BP (≥140/90 mmHg without antihypertensive drugs), controlled BP (<140/90 mmHg with antihypertensive drugs), and uncontrolled BP (≥140/90 mmHg with antihypertensive drugs). The prevalence of small for gestational age was 1,087/17,476 offspring in normal BP, 78/604 in high BP, 5/42 in controlled BP, and 7/33 in uncontrolled BP. Compared to normal BP, adjusted odds ratios (ORs) (95% confidence intervals (CIs)) were 1.76 (1.32-2.35) for high BP, 2.08 (0.79-5.50) for controlled BP, and 2.34 (0.94-5.85) for uncontrolled BP (multiple logistic regression analysis). Similarly, the adjusted ORs (95% CIs) were 1.80 (1.35-2.41), 3.42 (1.35-8.63), and 5.10 (1.93-13.45) for high, controlled, and uncontrolled BPs for low birth weight, respectively; 1.99 (1.48-2.68), 2.70 (1.12-6.50), and 6.53 (3.09-13.82) for high, controlled, and uncontrolled BPs for preterm birth, respectively; 1.64 (1.19-2.24), 2.17 (0.88-5.38), and 2.12 (0.80-5.65) for high, controlled, and uncontrolled BPs for admission to the Neonatal Intensive Care Unit or Growing Care Unit, respectively; and 1.17 (0.70-1.95), 2.23 (0.65-7.68), and 0.91 (0.20-4.16) for high, controlled, and uncontrolled BPs for 1-min Apgar score < 7, respectively. BP ≥ 140/90 mmHg might be taken care for preventing various adverse perinatal outcomes.
Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, Fumiko Matsuzaki, Rieko Hatanaka, Ryo Obara, Kei Morishita, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Shinichi Kuriyama

European journal of clinical pharmacology　2024/04/17

DOI： 10.1007/s00228-024-03685-7 　

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PURPOSE: To elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: Questionnaires were distributed to pregnant women participating in the TMM BirThree Cohort Study (from July 2013 to March 2017) around 12 weeks (early pregnancy) and 26 weeks (middle pregnancy). We analysed medication use over three periods: (1) 12 months prior to pregnancy diagnosis, (2) the period between pregnancy diagnosis and around week 12 of pregnancy, and (3) post around week 12 of pregnancy. RESULTS: In total, 19,297 women were included in the analysis. The proportion of pregnant women using medications was 49.0% prior to pregnancy diagnosis, 52.1% from diagnosis to week 12, and 58.4% post week 12 of pregnancy. The most frequently prescribed medications were loxoprofen sodium hydrate (5.5%) prior to pregnancy diagnosis, magnesium oxide (5.9%) from diagnosis to week 12, and ritodrine hydrochloride (10.5%) post week 12 of pregnancy. The number of women who used suspected teratogenic medications during early pregnancy was 96 prior to pregnancy diagnosis, 48 from diagnosis to week 12, and 54 post week 12 of pregnancy. CONCLUSION: We found that ~ 50% of the pregnant women used medications before and during pregnancy and some took potential teratogenic medications during pregnancy. In birth genomic cohort study, it is expected that investigations into the safety and effectiveness of medications used during pregnancy will advance.
平日と休日の睡眠時間の差と家庭高血圧との関連

野路慶明, 畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 時岡紗由理, 中村智洋, 栗山進一, 寳澤篤

日本循環器病予防学会誌　59　(2)　127-127　2024/04
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study. International-journal

Yudai Yonezawa, Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

BMC pregnancy and childbirth　24　(1)　209-209　2024/03/20

DOI： 10.1186/s12884-024-06376-4 　

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BACKGROUND: Nausea and vomiting during pregnancy (NVP) and hyperemesis gravidarum (HG), common conditions affecting most pregnant women, are highly heritable and associated with maternal and fetal morbidity. However, the pathologies underlying NVP and HG and their associated loci are scarce. METHODS: We performed genome-wide association studies (GWAS) of NVP in pregnant women (n = 23,040) who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from July 2013 to March 2017. Participants were divided into discovery (n = 9,464) and replication (n = 10,051) stages based on the platform used for their genotyping. Loci that achieved the genome-wide significance level (p < 5.0 × 10- 8) in the discovery stage were selected for genotyping in the replication stage. A meta-analysis integrating the discovery and replication stage results (n = 19,515) was conducted. NVP-related variables were identified as categorical or continuous. RESULTS: GWAS analysis in the discovery phase revealed loci linked to NVP in two gene regions, 11q22.1 (rs77775955) and 19p13.11 (rs749451 and rs28568614). Loci in these two gene regions have also been shown to be associated with HG in a White European population, indicating the generalizability of the GWAS analyses conducted in this study. Of these, only rs749451 and rs28568614 at 19p13.11 reached the genome-wide suggestive level (p < 1.0 × 10- 5) in the replication stage; however, both loci were significant in the meta-analysis. CONCLUSIONS: NVP-related loci were identified in the Japanese population at 11q22.1 and 19p13.11, as reported in previous GWAS. This study contributes new evidence on the generalizability of previous GWAS on the association between genetic background and NVP.
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory

Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, Mami Ishikuro, Natsuko Kobayashi, Saya Kikuchi, Xue Li, Aoi Noda, Keiko Murakami, Gen Tamiya, Junichi Sugawara, Hiroaki Tomita, Shinichi Kuriyama

Depression and Anxiety　2024　1-13　2024/03/15
Publisher: Wiley
DOI： 10.1155/2024/6622666 　

ISSN： 1091-4269

eISSN： 1520-6394

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This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.
Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. International-journal

Satoshi Mizuno, Maiko Wagata, Satoshi Nagaie, Mami Ishikuro, Taku Obara, Gen Tamiya, Shinichi Kuriyama, Hiroshi Tanaka, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara, Soichi Ogishima

Scientific reports　14　(1)　6292-6292　2024/03/15

DOI： 10.1038/s41598-024-55914-9 　

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Recently, many phenotyping algorithms for high-throughput cohort identification have been developed. Prospective genome cohort studies are critical resources for precision medicine, but there are many hurdles in the precise cohort identification. Consequently, it is important to develop phenotyping algorithms for cohort data collection. Hypertensive disorders of pregnancy (HDP) is a leading cause of maternal morbidity and mortality. In this study, we developed, applied, and validated rule-based phenotyping algorithms of HDP. Two phenotyping algorithms, algorithms 1 and 2, were developed according to American and Japanese guidelines, and applied into 22,452 pregnant women in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank project. To precise cohort identification, we analyzed both structured data (e.g., laboratory and physiological tests) and unstructured clinical notes. The identified subtypes of HDP were validated against reference standards. Algorithms 1 and 2 identified 7.93% and 8.08% of the subjects as having HDP, respectively, along with their HDP subtypes. Our algorithms were high performing with high positive predictive values (0.96 and 0.90 for algorithms 1 and 2, respectively). Overcoming the hurdle of precise cohort identification from large-scale cohort data collection, we achieved both developed and implemented phenotyping algorithms, and precisely identified HDP patients and their subtypes from large-scale cohort data collection.
Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Geng Chen, Mami Ishikuro, Hisashi Ohseto, Keiko Murakami, Aoi Noda, Genki Shinoda, Masatsugu Orui, Taku Obara, Shinichi Kuriyama

Acta obstetricia et gynecologica Scandinavica　2024/03/07

DOI： 10.1111/aogs.14820 　

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INTRODUCTION: Developmental delay at an early age indicates the probability of continued problems after school age. Hypertensive disorders of pregnancy (HDP) are associated with developmental delays in offspring, with inconsistent outcomes. Neonatal outcomes vary according to HDP exposure and are relevant to development in later years. Here we aimed to clarify the relationship between HDP and developmental delay in offspring and whether neonatal outcomes mediate this association. MATERIAL AND METHODS: We used data from 5934 mother-child pairs from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study conducted in Japan between July 2013 and March 2017. The Ages and Stages Questionnaires, third edition, at 24 and 42 months of age, measured developmental delay in five areas. We performed multivariate quasi-Poisson regression and causal mediation analysis by neonatal outcomes. RESULTS: At 24 months of age, compared to offspring born from normotensive mothers, offspring born from HDP-affected mothers were more likely to experience developmental delay (risk ratio [RR] 1.29, 95% confidence interval [CI]: 1.09-1.52) in the areas of communication (RR 1.21, 95% CI: 1.00-1.45) and personal-social (RR 1.15, 95% CI: 1.03-1.28). This association was mediated by neonatal outcomes: preterm birth, neonatal asphyxia, NICU admission, and neonatal small head circumference. No association was observed between HDP and developmental delay at 42 months of age. CONCLUSIONS: Exposure to HDP during fetal life is associated with offspring developmental delay. This association is partly mediated by neonatal outcomes.
Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. International-journal

Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Tomohiro Nakamura, Naho Tsuchiya, Haruki Momma, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Ryoichi Nagatomi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

BMC public health　24　(1)　714-714　2024/03/05

DOI： 10.1186/s12889-024-18244-z 　

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BACKGROUND: Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. METHODS: We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. RESULTS: Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. CONCLUSIONS: Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.
Dietary habits and plasma lipid concentrations in a general Japanese population. International-journal

Mitsuharu Sato, Eiji Hishinuma, Naomi Matsukawa, Yoshiko Shima, Daisuke Saigusa, Ikuko N Motoike, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Masayuki Yamamoto, Seizo Koshiba, Kengo Kinoshita

Metabolomics : Official journal of the Metabolomic Society　20　(2)　34-34　2024/03/05

DOI： 10.1007/s11306-024-02087-1 　

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INTRODUCTION: Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health. OBJECTIVES: As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population. METHODS: We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan. RESULTS: Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption. CONCLUSION: This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.
Role of Genetic Risk in the Association Between Screen Time and Child Development. International-journal

Ippei Takahashi, Taku Obara, Shinichi Kuriyama

JAMA pediatrics　178　(3)　317-318　2024/03/01

DOI： 10.1001/jamapediatrics.2023.6106 　
Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study

Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Taku Obara, Mami Ishikuro, Yuka Kotozaki, Akira Uruno, Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Hideki Ohmomo, Nobuo Fuse, Junichi Sugawara, Atsushi Shimizu, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Hypertension Research　2024/02/29
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41440-024-01582-1 　

ISSN： 0916-9636

eISSN： 1348-4214

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Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines for the Management of Hypertension. However, large-scale studies on the association of smoking, potassium excretion, and gamma-glutamyl transferase level with BP in the Japanese population are limited. We conducted a cross-sectional study to examine the association between hypertension risk factors and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study (23,446 men and 38,921 women aged ≥20 years). A model adjusted for age, body mass index, smoking status, drinking status, estimated daily salt intake, potassium excretion, (or urinary sodium-to-potassium ratio), gamma-glutamyl transferase, physical activity, education level, status of damage to homes during the Great East Japan Earthquake, and residential areas was used. The average age and systolic blood pressure were 62.5 (10.3) years for men and 59.6 (11.3) years for women, 128.9 (16.7) mmHg for men and 124.7 (17.5) mmHg for women, respectively. Body mass index estimated daily salt intake, urinary sodium-to-potassium ratio and gamma-glutamyl transferase levels were positively associated with systolic blood pressure. Compared with never-drinkers, current drinkers who consumed 23–45 g/day and ≥46.0 g/day had significantly increased systolic blood pressure. Conversely, current smokers (1-10 cigarettes/day and 11-20 cigarettes/day) were inversely associated with systolic blood pressure compared to never-smokers. Overall, systolic blood pressure was associated with gamma-glutamyl transferase and hypertension risk factors, including body mass index, alcohol consumption, estimated daily salt intake, urinary sodium-to-potassium ratio, and potassium excretion. Our findings support the notion that lifestyle modifications should be attempted to prevent hypertension.
Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Junichi Sugawara, Eiichi Kodama, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Naho Tsuchiya, Takumi Hirata, Akira Narita, Akito Tsuboi, Toru Tamahara, Akihito Otsuki, Maki Goto, Makiko Taira, Ritsuko Shimizu, Kichiya Suzuki, Taku Obara, Masahiro Kikuya, Hirohito Metoki, Mami Ishikuro, Inaho Danjoh, Soichi Ogishima, Satoshi Nagaie, Naoko Minegishi, Masahiro Hiratsuka, Kazuki Kumada, Ichiko Nishijima, Takahiro Nobukuni, Yumi Yamaguchi-Kabata, Fuji Nagami, Shigeo Kure, Nobuo Fuse, Kengo Kinoshita, Yoko Izumi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　2024/02/24

DOI： 10.2188/jea.JE20230241 　

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BACKGROUND: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. METHODS: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). RESULTS: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. CONCLUSIONS: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.
Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

Journal of diabetes investigation　2024/02/23

DOI： 10.1111/jdi.14159 　

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AIMS: This study aimed to investigate the association of maternal birth weight (MBW) with early and late gestational diabetes mellitus (GDM). METHODS: A total of 69318 pregnant Japanese women were included in this birth cohort study. The associations between maternal birth weight and early gestational diabetes mellitus (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were investigated using a multinomial logistic regression model, with an maternal birth weight of 3000-3499 g as the reference category. RESULTS: Lower maternal birth weight was associated with higher odds of developing early and late gestational diabetes mellitus (P < 0.0001 and P < 0.0001, respectively). The adjusted odds ratios (aORs) for early gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were 1.345 (95% confidence interval [CI]: 0.912-1.984) and 1.338 (95% CI: 1.098-1.629), respectively. The aORs for late gestational diabetes mellitus in participants with a MBW of <2500 g and 2500-2999 g were, 1.657 (95% CI: 1.298-2.115) and 1.218 (95% CI: 1.058-1.402), respectively. CONCLUSIONS: Regardless of the gestational age when gestational diabetes mellitus was diagnosed, a lower maternal birth weight was associated with an increased risk of gestational diabetes mellitus. Furthermore, the association of a MBW <2500 g with late gestational diabetes mellitus tended to be stronger than that with early gestational diabetes mellitus.
Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2024/02/06

DOI： 10.5551/jat.64535 　

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AIMS: Although fat mass (FM) and fat-free mass (FFM) have an impact on lipid metabolism, the relationship between different body composition phenotypes and lipid profiles is still unclear. By dividing the FM and FFM by the square of the height, respectively, the f at mass index (FMI) and fat-free mass index (FFMI) can be used to determine the variations in body composition. This study aimed to investigate the relationship of combined FMI and FFMI with low-density lipoprotein cholesterol (LDL-C) levels. METHODS: This cross-sectional study comprised 5,116 men and 13,630 women without cardiovascular disease and without treatment for hypertension, and diabetes. Following sex-specific quartile classification, FMI and FFMI were combined into 16 groups. Elevated LDL-C levels were defined as LDL-C ≥ 140 mg/dL and/or dyslipidemia treatment. Multivariable logistic regression models were used to examine the relationships between combined FMI and FFMI and elevated LDL-C levels. RESULTS: Overall, elevated LDL-C levels were found in 1,538 (30.1%) men and 5,434 (39.9%) women. In all FFMI subgroups, a higher FMI was associated with elevated LDL-C levels. Conversely, FFMI was inversely associated with elevated LDL-C levels in most FMI subgroups. Furthermore, the groups with the highest FMI and lowest FFMI had higher odds ratios for elevated LDL-C levels than those with the lowest FMI and highest FFMI. CONCLUSIONS: Regardless of FFMI, FMI was positively associated with elevated LDL-C levels. Conversely, in the majority of FMI subgroups, FFMI was inversely associated with elevated LDL-C levels.
Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study

Hirotaka Hamada, Noriyuki Iwama, Hasumi Tomita, Kazuma Tagami, Natsumi Kumagai, Rie Kudo, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hirohito Metoki, Masatoshi Saito, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Nutrients　16　(4)　2024/02

DOI： 10.3390/nu16040531 　

eISSN： 2072-6643
The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children's study. International-journal

Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Rie Kudo, Kazuma Tagami, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Journal of developmental origins of health and disease　1-12　2024/01/22

DOI： 10.1017/S2040174423000387 　

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This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43-1.58) and 1.31 (95% CI, 1.25-1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47-1.60) and 1.41 (95% CI, 1.35-1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40-1.55) and 1.25 (95% CI, 1.19-1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41-1.79) and 1.40 (95% CI, 1.23-1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.
Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. International-journal

Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, Ryutaro Arita, Minoru Ohsawa, Ryo Obara, Kei Morishita, Fumihiko Ueno, Genki Shinoda, Masatsugu Orui, Keiko Murakami, Mami Ishikuro, Akiko Kikuchi, Shin Takayama, Tadashi Ishii, Hiroshi Kawame, Shigeo Kure, Shinichi Kuriyama

Drugs - real world outcomes　2024/01/19

DOI： 10.1007/s40801-023-00411-0 　

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BACKGROUND: Japanese traditional (Kampo) medicines containing ephedra may be used to treat colds during pregnancy. There are reports that ephedrine, a component of ephedra, has a risk of teratogenicity; however, the evidence remains equivocal. OBJECTIVE: This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with exposure to Kampo medicines containing ephedra during the first trimester of pregnancy using the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). METHODS: To 23,730 mother-infant pairs who participated in the TMM BirThree Cohort Study from July 2013 to March 2017, questionnaires in early and middle pregnancy were distributed approximately at weeks 12 and 26 of pregnancy, respectively. Infants' risk of MCMs in women who used Kampo medicines containing ephedra or acetaminophen during the first trimester was assessed, and the odds ratios (ORs) were estimated with unadjusted and adjusted analyses. RESULTS: Among 20,879 women, acetaminophen and Kampo medicines containing ephedra were used in 665 (3.19%) and 376 (1.80%) women, respectively, in the first trimester. Among the infants born to the mothers who used acetaminophen or Kampo medicine containing ephedra during the first trimester, 11 (1.65%) and 8 (2.13%), respectively, had overall MCMs. OR of overall MCMs was higher in women who used Kampo medicines containing ephedra than in those who used acetaminophen in the first trimester (adjusted OR, 1.45; 95% confidence interval (CIs), 0.57-3.71); however, the difference was not statistically significant. CONCLUSIONS: In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.
Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. International-journal

Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, Taku Obara, Noriyuki Iwama, Keiko Murakami, Md Shafiur Rahman, Maki Tojo, Sumitaka Kobayashi, Chihiro Miyashita, Keiko Tanaka, Yoshihiro Miyake, Kazue Ishitsuka, Reiko Horikawa, Naho Morisaki, Midori Yamamoto, Kenichi Sakurai, Chisato Mori, Atsushi Shimizu, Fumihiro Sata, Kenji J Tsuchiya, Reiko Kishi, Shinichi Kuriyama

Journal of human hypertension　2024/01/10

DOI： 10.1038/s41371-023-00890-2 　
Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community‐based cohort study

Hongxin Wang, Noriyuki Iwama, Keiichi Yuwaki, You Nakamichi, Hirotaka Hamada, Hasumi Tomita, Kazuma Tagami, Rie Kudo, Natsumi Kumagai, Hirohito Metoki, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Masatoshi Saito

The Journal of Clinical Hypertension　2024/01/08

DOI： 10.1111/jch.14756 　
The 2024 Noto Peninsula Earthquake and the Strategy of Medical Assistance from the Tohoku University Hospital.

Shinichi Egawa, Tadashi Ishii, Hajime Furukawa, Motoo Fujita, Yoshiko Abe, Aisa Sakamoto, Yohei Inaba, Katsunori Ono, Hideo Harigae, Motohiro Tsuboi, Shinichi Kuriyama, Hiroyuki Sasaki

The Tohoku journal of experimental medicine　262　(1)　45-49　2024

DOI： 10.1620/tjem.2024.J010 　

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A moment magnitude (Mw) 7.5 earthquake (the Global IDentifire (GLIDE) number: # Q-2024-000001-JPN) struck the Noto Peninsula of Ishikawa Prefecture on 1 January 2024 at 16:10 (Japan Standard Time). The reversed fault, 150 km in length and subducting beneath the peninsula, resulted in maximum seismic intensity 7 shaking, triggered the tsunami, destroyed over 43 thousand buildings, and disrupted roads and lifelines. The disaster claimed 236 deaths, including 15 indirect disaster deaths as of Jan. 28, 2024. There were Disaster Base Hospitals (DBHs) in the region, which survived structurally but suffered from impaired functions and the surge of medical needs of affected people. The disaster medical system of Japan immediately responded and coordinated the hundreds of emergency medical teams (EMTs), i.e., the Japan Disaster Medical Assistance Team (DMAT), from all over the country. Tohoku University Hospital, which had the experience of the 2011 Great East Japan Earthquake (GEJE), joined the coordinated response, dispatching a chain of DMATs, which helped the medical and public health coordination in Wajima City. The medical and public health needs included injuries, non-communicable diseases, infectious diseases, mental health issues, and maternal and child health issues, which were similar in the affected communities in GEJE. Although the actual damage far exceeded expectations, the structural retrofitting and business continuity plans of DBHs and the coordinated response of the national disaster medical system enhanced the effectiveness of medical and public health response.
遺伝要因、生活習慣の組み合わせと糖尿病発症の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 中村智洋, 後岡広太郎, 土屋菜歩, 平田匠, 松田浩一, 栗山進一, 木下賢吾, 田宮元, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　176-176　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
尿中Na、K、Na/K比と胃がん罹患との関連東北メディカル・メガバンク計画地域住民コホート調査

小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 小原拓, 永家聖, 布施昇男, 泉陽子, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　100-100　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 小原拓, 宇留野晃, 布施昇男, 泉陽子, 栗山進一, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　133-133　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
ToMMo地域住民コホート調査におけるPreserved ratio impairment spirometryの有病と関連する要因の検討

岩崎史, 中谷久美, 山田充啓, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類真嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 杉浦久敏, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　139-139　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Alcohol Flushingと悪性腫瘍有病の関連 TMM計画地域住民コホート調査(宮城)

土谷祐馬, 中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 石黒真美, 大類正嗣, 永家聖, 中村智洋, 荻島創一, 布施昇男, 泉陽子, 栗山進一, 亀井尚, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　154-154　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
産後うつ・自殺問題の縦断的リスクと関連要因の検討東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 岩間憲之, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 目時弘仁, 菊谷昌浩, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　34　(Suppl.)　158-158　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
震災による自宅損壊および心的外傷後ストレス反応と修正可能な認知症の危険因子の関連

千葉一平, 小暮真奈, 中谷久美, 畑中里衣子, 小原拓, 丹野高三, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　34　(Suppl.)　174-174　2024/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, Takahiro Nobukuni, Soichi Ogishima, Satoshi Mizuno, Seizo Koshiba, Shinichi Kuriyama, Kinuko Ohneda, Masashi Morifuji

Nutrients　16　(1)　2023/12/31

DOI： 10.3390/nu16010145 　

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(1) Background: Breast milk is the only source of nutrition for breastfed infants, but few studies have examined the relationship between breast milk micronutrients and infant neurodevelopmental outcome in exclusively breastfed infants. The aim of this study was to characterize the association between nicotinamide adenine dinucleotide (NAD)-related compounds in the breast milk of Japanese subjects and infant neurodevelopmental outcome. (2) Methods: A total of 150 mother-child pairs were randomly selected from the three-generation cohort of the Tohoku Medical Megabank in Japan. Infants were exclusively breastfed for up to 6 months. Breast milk was collected at 1 month postpartum, and the quantity of NAD-related substances in the breast milk was quantified. The mothers also completed developmental questionnaires at 6, 12, and 24 months. The relationship between the concentration of NAD-related substances in breast milk and developmental indicators was evaluated via ordinal logistic regression analysis. (3) Results: Nicotinamide mononucleotide (NMN) was quantified as the major NAD precursor in breast milk. The median amount of NMN in the breast milk was 9.2 μM. The NMN concentration in breast milk was the only NAD-related substance in breast milk that showed a significant positive correlation with neurodevelopmental outcome in infants at 24 months. (4) Conclusions: The results suggest that NMN in human milk may be an important nutrient for early childhood development.
Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, Aoi Noda, Genki Shinoda, Masatsugu Orui, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama

Nutrition journal　22　(1)　66-66　2023/12/06

DOI： 10.1186/s12937-023-00901-5 　

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BACKGROUND: Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association of the timing of meal intake and development delays remains unclear. We examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7491 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5-6, 3-4, and 0-2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years. RESULTS: The proportion of pregnant women who had breakfast daily was 78.1% in pre- to early pregnancy, and 82.2% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0-2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.30, (95% confidence interval [CI], 1.02-1.66). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0-2 times/week in early to mid- pregnancy: OR 1.75 (95% CI, 1.32-2.32). The risk of developmental delays at age 3.5 years did not increase in the children of women who had breakfast 0-2 times/week from pre- to early and early to mid-pregnancy: OR 1.06 (95% CI, 0.81-1.39 and OR 1.15 (95% CI 0.84-1.57), respectively. CONCLUSION: For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.
Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study. International-journal

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Naoto Sato, Seiya Izumi, Kasumi Sakurai, Zen Watanabe, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Tetsuro Hoshiai, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi

Pregnancy hypertension　34　159-168　2023/11/21

DOI： 10.1016/j.preghy.2023.11.002 　

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OBJECTIVES: This study aimed to investigate the association between maternal birth weight (MBW) and hypertensive disorders of pregnancy (HDP) according to the gestational age when HDP develops. STUDY DESIGN: A total of 77,345 subjects were included in this prospective birth cohort study. The association between MBW and HDP was investigated by a multinomial logistic regression model. MAIN OUTCOME MEASURES: Early-onset HDP (EO-HDP), preterm late-onset HDP (preterm LO-HDP), and term late-onset HDP (term LO-HDP). RESULTS: Lower MBW was associated with higher odds of preterm and term LO-HDP (p-values for trend < 0.0001 and = 0.0005, respectively). A linear association between MBW and EO-HDP was observed (p-values for trend = 0.0496). The shape of the association between MBW and preterm LO-HDP was a combination of the associations between MBW with EO-HDP or LO-HDP. The effect size of the association between MBW < 2,500 g and EO-HDP was lower than that of MBW < 2,500 g with preterm or term LO-HDP. The adjusted odds ratios for EO-HDP, preterm LO-HDP, and term LO-HDP in subjects with MBW < 2,500 g were 1.052 (95 % confidence interval [CI]: 0.665-1.664), 1.745 (95 % CI: 1.220-2.496), and 1.496 (95 % CI: 1.154-1.939), respectively. CONCLUSIONS: MBW was associated with HDP, regardless of gestational age when HDP developed. Furthermore, the association of MBW < 2,500 g with preterm or term LO-HDP was stronger than that with EO-HDP.
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. International-journal

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Yohei Hamanaka, Masatsugu Orui, Tomoko Kobayashi, Akira Uruno, Eiichi N Kodama, Satoshi Nagaie, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　2023/10/31

DOI： 10.1038/s41440-023-01484-8 　

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Masked hypertension is a risk factor for cardiovascular diseases. However, masked hypertension is sometimes overlooked owing to the requirement for home blood pressure measurements for diagnosing. Mental status influences blood pressure. To reduce undiagnosed masked hypertension, this study assessed the association between depressive symptoms and masked hypertension. This cross-sectional study used data from the Tohoku Medical Megabank Project Community-Based Cohort Study (conducted in Miyagi Prefecture, Japan, from 2013) and included participants with normotension measured at the research center (systolic blood pressure<140 mmHg and diastolic blood pressure <90 mmHg). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (Japanese version). Masked hypertension was defined as normotension measured at the research center and home hypertension (home systolic blood pressure ≥135 mmHg or home diastolic blood pressure ≥85 mmHg). The study comprised 6705 participants (mean age: 55.7 ± 13.7 years). Of these participants, 1106 (22.1%) without depressive symptoms and 393 (23.2%) with depressive symptoms were categorized to have masked hypertension. Sex-specific and age-adjusted least mean squares for home blood pressure, not for research blood pressure were significantly higher in the group with depressive symptoms in both sex categories. The multivariate odds ratio for masked hypertension in the patients with depressive symptoms was 1.72 (95% confidence interval: 1.26-2.34) in male participants and 1.30 (95% confidence interval: 1.06-1.59) in female ones. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at the research center. Depressive symptoms may be one of the risk factors for masked hypertension. Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.
The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study

Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Hideaki Hashimoto, Tomohiro Nakamura, Kotaro Nochioka, Taku Obara, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Akira Uruno, Eiichi N. Kodama, Nobuo Fuse, Shinichi Kuriyama, Atsushi Hozawa

Hypertension Research　2023/10/13
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41440-023-01454-0 　

ISSN： 0916-9636

eISSN： 1348-4214

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Abstract This study aimed to examine whether risk of withdrawal from HTTx was higher in coastal areas that were severely damaged by tsunami than in inland areas. We conducted a cross-sectional study of 9218 participants aged ≥20 years in Miyagi, Japan. The odds ratios (ORs) and confidence interval (CI) for withdrawal from HTTx in coastal and inland groups were compared using multivariate logistic regression analysis, adjusting for potential confounders. In total, 194 of 5860 and 146 of 3358 participants in the inland and coastal groups, respectively, withdrew from HTTx treatment. OR (95%CI) of withdrawal from HTTx in the coastal group was 1.46 (1.14–1.86) compared to the inland group. According to housing damage, ORs (95% CI) in the no damage, partially destroyed, and more than half destroyed coastal groups compared with the no damage inland group were 1.62 (1.04–2.50), 1.69 (1.17–2.45), and 1.08 (0.71–1.65), respectively. In conclusion, the risk of HTTx withdrawal for participants whose homes in coastal areas were relatively less damaged was significantly higher compared with those in inland areas, while the risk of HTTx withdrawal for participants whose homes were more than half destroyed was not. Post-disaster administrative support for disaster victims is considered vital for continuation of their treatment.
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Akira Narita, Taku Obara, Mami Ishikuro, Akira Uruno, Tomoko Kobayashi, Eiichi N Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto

Journal of atherosclerosis and thrombosis　2023/10/06

DOI： 10.5551/jat.64425 　

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AIM: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. METHODS: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. RESULTS: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92-7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73-6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65-3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. CONCLUSIONS: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.
脂肪量指数と除脂肪量指数の組み合わせと高LDLコレステロール血症の関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 後岡広太郎, 土屋菜歩, 平田匠, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　272-272　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災による家屋損壊の程度と要支援・要介護認定・死亡リスクとの関連

滑川千慧, 小暮真奈, 菅野郁美, 畑中里衣子, 中谷久美, 千葉一平, 平田匠, 宇留野晃, 布施昇男, 中谷直樹, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　286-286　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画三世代コホート調査これまでの進捗

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寶澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画三世代コホート調査における追加リクルート

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 村上慶子, 菅野郁美, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　370-370　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
コホート調査データの連係・活用推進のための基盤整備マイToMMoの開発と実装

野田あおい, 篠田元気, 石黒真美, 千葉一平, 大類真嗣, 村上慶子, 小原拓, 菅野郁美, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　82回　371-371　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査(宮城) これまでの進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 石黒真美, 大類真嗣, 野田あおい, 篠田元気, 村上慶子, 小原拓, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　82回　398-398　2023/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. International-journal Peer-reviewed

Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, Ippei Chiba, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Ryosuke Ishiwata, Tomohiro Nakamura, Ikuko N Motoike, Naoki Nakaya, Seizo Koshiba, Kengo Kinoshita, Shinichi Kuriyama, Soichi Ogishima, Fuji Nagami, Nobuo Fuse, Atsushi Hozawa

Journal of Alzheimer's disease : JAD　2023/09/11

DOI： 10.3233/JAD-230318 　

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BACKGROUND: Olfactory function decline has recently been reported to be associated with a risk of cognitive impairment. Few population-based studies have included younger adults when examining the association between olfactory test data with multiple odor intensities and suspected cognitive impairment. OBJECTIVE: We investigated the association between high-resolution olfactory test data with fewer odors and suspected cognitive impairments. We also examined the differences between older and younger adults in this association. METHODS: The Japanese version of the Montreal Cognitive Assessment (MoCA-J) was administered to 1,450 participants, with three odor-intensity-level olfactometry using six different odors. Logistic regressions to discriminate suspected cognitive impairment were conducted to examine the association, adjusted for age, sex, education duration, and smoking history. Data were collected from the Program by Tohoku University Tohoku Medical Megabank Organization, with an additional olfactory test conducted between 2019 and 2021. RESULTS: We generally observed that the lower the limit of distinguishable odor intensity was, the higher the MoCA-J score was. The combination of spearmint and stuffy socks contributed most to the distinction between suspected and unsuspected cognitive impairment. Furthermore, the association was significant in women aged 60-74 years (adjusted odds ratio 0.881, 95% confidence interval [0.790, 0.983], p = 0.024). CONCLUSIONS: The results indicate an association between the limit of distinguishable odor intensity and cognitive function. The olfactory test with multiple odor intensity levels using fewer odors may be applicable for the early detection of mild cognitive impairment, especially in older women aged 60-74 years.
分娩回数と高血圧との関連東北メディカル・メガバンク機構地域住民コホート調査

内堀洪欣, 岩間憲之, 湯脇恵一, 中道洋, 濱田裕貴, 富田芙弥, 田上和磨, 工藤理永, 熊谷奈津美, 目時弘仁, 中谷直樹, 寳澤篤, 栗山進一, 八重樫伸生, 齋藤昌利

日本妊娠高血圧学会雑誌　29　G-06　2023/09
Publisher: (一社)日本妊娠高血圧学会
ISSN： 1880-3172
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09
Publisher: (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09
Publisher: (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　261-261　2023/09
Publisher: (NPO)日本高血圧学会
高血圧の家族歴、遺伝要因、生活習慣の組み合わせと家庭高血圧の関連東北メディカル・メガバンク地域住民コホート調査

高瀬雅仁, 平田匠, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 目時弘仁, 佐藤倫広, 小原拓, 栗山進一, 田宮元, 寳澤篤

日本高血圧学会総会プログラム・抄録集　45回　358-358　2023/09
Publisher: (NPO)日本高血圧学会
Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. International-journal

Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, Taku Obara, Mami Ishikuro, Hiroshi Tanaka, Kengo Kinoshita, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Soichi Ogishima

BMC pregnancy and childbirth　23　(1)　628-628　2023/08/31

DOI： 10.1186/s12884-023-05919-5 　

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BACKGROUND: Low birth weight (LBW) is a leading cause of neonatal morbidity and mortality, and increases various disease risks across life stages. Prediction models of LBW have been developed before, but have limitations including small sample sizes, absence of genetic factors and no stratification of neonate into preterm and term birth groups. In this study, we challenged the development of early prediction models of LBW based on environmental and genetic factors in preterm and term birth groups, and clarified influential variables for LBW prediction. METHODS: We selected 22,711 neonates, their 21,581 mothers and 8,593 fathers from the Tohoku Medical Megabank Project Birth and Three-Generation cohort study. To establish early prediction models of LBW for preterm birth and term birth groups, we trained AI-based models using genetic and environmental factors of lifestyles. We then clarified influential environmental and genetic factors for predicting LBW in the term and preterm groups. RESULTS: We identified 2,327 (10.22%) LBW neonates consisting of 1,077 preterm births and 1,248 term births. Our early prediction models archived the area under curve 0.96 and 0.95 for term LBW and preterm LBW models, respectively. We revealed that environmental factors regarding eating habits and genetic features related to fetal growth were influential for predicting LBW in the term LBW model. On the other hand, we identified that genomic features related to toll-like receptor regulations and infection reactions are influential genetic factors for prediction in the preterm LBW model. CONCLUSIONS: We developed precise early prediction models of LBW based on lifestyle factors in the term birth group and genetic factors in the preterm birth group. Because of its accuracy and generalisability, our prediction model could contribute to risk assessment of LBW in the early stage of pregnancy and control LBW risk in the term birth group. Our prediction model could also contribute to precise prediction of LBW based on genetic factors in the preterm birth group. We then identified parental genetic and maternal environmental factors during pregnancy influencing LBW prediction, which are major targets for understanding the LBW to address serious burdens on newborns' health throughout life.
Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years. International-journal

Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Genki Shinoda, Tomoko Nishimura, Kenji J Tsuchiya, Shinichi Kuriyama

JAMA pediatrics　2023/08/21

DOI： 10.1001/jamapediatrics.2023.3057 　

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IMPORTANCE: Whether some domains of child development are specifically associated with screen time and whether the association continues with age remain unknown. OBJECTIVE: To examine the association between screen time exposure among children aged 1 year and 5 domains of developmental delay (communication, gross motor, fine motor, problem-solving, and personal and social skills) at age 2 and 4 years. DESIGN, PARTICIPANTS, AND SETTING: This cohort study was conducted under the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Pregnant women at 50 obstetric clinics and hospitals in the Miyagi and Iwate prefectures in Japan were recruited into the study between July 2013 and March 2017. The information was collected prospectively, and 7097 mother-child pairs were included in the analysis. Data analysis was performed on March 20, 2023. EXPOSURE: Four categories of screen time exposure were identified for children aged 1 year (<1, 1 to <2, 2 to <4, or ≥4 h/d). MAIN OUTCOMES AND MEASURES: Developmental delays in the 5 domains for children aged 2 and 4 years were assessed using the Japanese version of the Ages & Stages Questionnaires, Third Edition. Each domain ranged from 0 to 60 points. Developmental delay was defined if the total score for each domain was less than 2 SDs from its mean score. RESULTS: Of the 7097 children in this study, 3674 were boys (51.8%) and 3423 were girls (48.2%). With regard to screen time exposure per day, 3440 children (48.5%) had less than 1 hour, 2095 (29.5%) had 1 to less than 2 hours, 1272 (17.9%) had 2 to less than 4 hours, and 290 (4.1%) had 4 or more hours. Children's screen time was associated with a higher risk of developmental delay at age 2 years in the communication (odds ratio [OR], 1.61 [95% CI, 1.23-2.10] for 1 to <2 h/d; 2.04 [1.52-2.74] for 2 to <4 h/d; 4.78 [3.24-7.06] for ≥4 vs <1 h/d), fine motor (1.74 [1.09-2.79] for ≥4 vs <1 h/d), problem-solving (1.40 [1.02-1.92] for 2 to <4 h/d; 2.67 [1.72-4.14] for ≥4 vs <1 h/d), and personal and social skills (2.10 [1.39-3.18] for ≥4 vs <1 h/d) domains. Regarding risk of developmental delay at age 4 years, associations were identified in the communication (OR, 1.64 [95% CI, 1.20-2.25] for 2 to <4 h/d; 2.68 [1.68-4.27] for ≥4 vs <1 h/d) and problem-solving (1.91 [1.17-3.14] for ≥4 vs <1 h/d) domains. CONCLUSIONS AND RELEVANCE: In this study, greater screen time for children aged 1 year was associated with developmental delays in communication and problem-solving at ages 2 and 4 years. These findings suggest that domains of developmental delay should be considered separately in future discussions on screen time and child development.
母親の妊娠中と産後の心理的苦痛と4歳時点における児の発達との関連三世代コホート調査

高橋一平, 小原拓, 菊地紗耶, 小林美佳, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 小林奈津子, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 富田博秋, 呉繁夫, 八重樫伸生, 栗山進一

DOHaD研究　11　(3)　29-29　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
出生コホート連携における年齢別の不妊治療と妊娠高血圧症候群との関連

石黒真美, 小原拓, 西村倫子, 岩田啓芳, 目時弘仁, 岩間憲之, 村上慶子, Shafiur Rahman, 小林澄貴, 宮下ちひろ, 石塚一枝, 田中景子, 三宅吉博, 堀川玲子, 森崎菜穂, 土屋賢治, 岸玲子, 栗山進一

DOHaD研究　11　(3)　36-36　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
妊娠初期の消化管運動改善薬の大奇形リスク大規模レセプトデータベースを用いた評価

小原拓, 石川智史, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

DOHaD研究　11　(3)　38-39　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
新生児臍帯血の網羅的エピゲノム解析による妊娠初期までの喫煙経験が次世代に及ぼす影響

美辺詩織, 小巻翔平, 大桃秀樹, 高嶋聰, 小野加奈子, 山崎弥生, 須藤洋一, 田高周, 水野聖士, 石黒真美, 工藤久智, 小原拓, 熊田和貴, 勝岡史城, 荻島創一, 木下賢吾, 菅原準一, 栗山進一, 清水厚志

DOHaD研究　11　(3)　37-37　2023/08
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. International-journal

Takashi Ohe, Mitsuhiro Yamada, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, Mana Kogure, Nobuo Fuse, Shinichi Kuriyama, Ayumi Mitsune, Ayumi Suzuki, Shuichiro Matsumoto, Tetsuya Hatakeyama, Chikashi Iwasaki, Manami Suzuki, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Akira Koarai, Tsutomu Tamada, Masayuki Yamamoto, Masakazu Ichinose, Hisatoshi Sugiura

Respiratory investigation　61　(5)　588-600　2023/07/08

DOI： 10.1016/j.resinv.2023.06.004 　

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BACKGROUND: Birth weight, as a measure of intrauterine growth, is commonly used in epidemiological studies and is reported to be associated with adult lung function. However, findings regarding this association in previous studies have been inconsistent. Furthermore, no studies have reported associations stratified by age or smoking status, or adjusted for eosinophil count or other parameters related to type 2 airway inflammation. METHODS: This cross-sectional study included 2632 men and 7237 women aged ≥20 years living in Miyagi Prefecture, Japan. Lung function was assessed based on spirometry. Birth weight data were obtained through a questionnaire survey. Analysis of covariance was used to evaluate the associations between birth weight and lung function, adjusting for potential confounders. Stratified analyses by age and smoking status were also conducted, together with a sub-analysis for low birth-weight participants. RESULTS: Birth weight was positively associated with forced expiratory volume in 1 s (FEV1) for both sexes and with vital capacity in women, after adjusting for height, age, smoking status, and parameters related to type 2 airway inflammation. The stratified analysis for smoking status revealed associations in never-smokers and ex-smokers. When stratified by age, the associations were confirmed in middle-aged participants. The effect of smoking status on the FEV1 of low birth-weight participants was not significant. CONCLUSIONS: Our analysis of a large, Japanese adult population showed that birth weight was independently and positively associated with adult lung function, even after adjustment for age, height, smoking status, and parameters related to type 2 airway inflammation.
Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure.

Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, Mana Kogure, Rieko Hatanaka, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Hirohito Metoki, Takahisa Murakami, Michihiro Satoh, Tomohiro Nakamura, Taku Obara, Yohei Hamanaka, Tomoko Kobayashi, Akira Uruno, Junichi Sugawara, Eiichi N Kodama, Soichi Ogishima, Yoko Izumi, Nobuo Fuse, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2023/07/05

DOI： 10.5551/jat.64151 　

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AIM: People with high normal blood pressure (BP) have a higher risk of cardiovascular events than those with normal BP; therefore, progression to hypertension (HT) should be prevented. We aimed to assess the HT risk using central BP and carotid intima media thickness (CIMT) in people with high normal BP. METHODS: This prospective cohort study used the Tohoku Medical Megabank Community-Based Project Cohort Study (conducted from 2013 in Miyagi Prefecture in Japan). The participants had a high normal BP, defined as a systolic BP of 120-139 mmHg and diastolic BP ＜90 mmHg using brachial BP measurement during the baseline survey. The outcome was new-onset HT during the secondary survey, conducted four years after the baseline survey. RESULTS: Overall, 4,021 participants with high normal BP during the baseline survey, with an average age of 58.7 years, were included; 1,030 (26%) were diagnosed with new-onset HT during the secondary survey, 3.5± 0.7 years after the baseline survey. The multivariable odds ratio (95% confidence interval) for HT in the highest versus lowest quartile of central BP was 1.7 (1.2-2.4, p=0.0030), and that of CIMT was 1.8 (1.4-2.4, p＜0.001). Subgroup analysis according to age (＜60 and ≥ 60 years) and sex revealed that the central BP was influential in groups with younger age and female individuals; CIMT was influential in all groups. CONCLUSIONS: Higher central BP and thicker CIMT at the baseline were correlated with new-onset HT in individuals with high normal BP, independent of brachial systolic BP and other cardiovascular risk factors.
産後女性のうつ・自殺関連問題の縦断的リスク評価の記述的分析東北メディカル・メガバンク計画三世代コホート調査

大類真嗣, 小原拓, 石黒真美, 野田あおい, 篠田元気, 千葉一平, 中谷久美, 畑中里衣子, 小暮真奈, 中谷直樹, 寳澤篤, 栗山進一

東北公衆衛生学会誌　(72)　25-25　2023/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Peer-reviewed

Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N. Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto

JMA Journal　6　(3)　246-264　2023/07
Publisher: Japan Medical Association
DOI： 10.31662/jmaj.2022-0220 　

ISSN： 2433-328X

eISSN： 2433-3298
On the Mental Health Needs Under the Russian Invasion in Ternopil, Ukraine: A Preliminary Report on the Provision of Mental Health Service

Mizuki Hino, Yasuto Kunii, Bogdan I. Gerashchenko, Yumiko Hamaie, Shinichi Egawa, Shinichi Kuriyama, Oksana O. Shevchuk, Mykhaylo M. Korda, Olena P. Venher, Hiroaki Tomita

Annals of Global Health　89　(1)　2023/06/08
Publisher: Ubiquity Press, Ltd.
DOI： 10.5334/aogh.4076 　

ISSN： 2214-9996
Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability International-journal

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Ryoko Kimura, Yumiko Hamaie, Mizuki Hino, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Susumu Fujii, Masaharu Nakayama, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in Psychiatry　14　1104222-1104222　2023/06/06
Publisher: Frontiers Media SA
DOI： 10.3389/fpsyt.2023.1104222 　

eISSN： 1664-0640
Factors associated with new onset of father-to-infant bonding failure from 1 to 6 months postpartum: an adjunct study of the Japan environment and children's study. International-journal

Taeko Suzuki, Toshie Nishigori, Taku Obara, Miyuki Mori, Kasumi Sakurai, Mami Ishikuro, Hirotaka Hamada, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Hirohito Metoki, Shinichi Kuriyama, Aya Goto, Nobuo Yaegashi, Hidekazu Nishigori

Social psychiatry and psychiatric epidemiology　58　(11)　1603-1624　2023/06/04

DOI： 10.1007/s00127-023-02505-0 　

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PURPOSE: This study aimed to determine the factors associated with new onset father-to-infant (paternal) bonding failure from 1 to 6 months postpartum. METHODS: This was a prospective birth-cohort study. Paternal bonding failure was evaluated using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) at 1 and 6 months postpartum. For cut-off scores, overall bonding failure, MIBS-J total scores ≥ 5; subscale for lack of affection, MIBS-J_LA scores ≥ 3; and subscale for anger/rejection, MIBS-J_AR scores ≥ 3 were used in this study. Multivariate regression analysis was performed to analyze relative variables. RESULTS: We analyzed 872 fathers. The frequency of new-onset overall bonding failure, lack of affection, and anger/rejection was 5.6%, 4.9%, and 6.3%, respectively. For new-onset overall bonding failure, significant associated factors were paternal childcare leave (adjusted odds ratio [AOR] 3.192; 95% confidence interval [CI] 1.203-8.469), paternal new-onset depression symptoms (AOR 3.181; 95% Cl 1.311-7.716), and maternal new-onset overall bonding failure (AOR 4.595; 95% Cl 1.119-18.866). For new-onset lack of affection, significant associated factors were preterm birth (AOR 4.189; 95% Cl 1.473-11.913) and paternal new-onset depression symptoms (AOR 3.290; 95% Cl 1.294-8.362). For new-onset anger and rejection, significant associated factors were paternal childcare leave (AOR 3.142; 95% Cl 1.138-8.676), paternal new-onset depression symptoms (AOR 2.829; 95% Cl 1.133-7.068), and maternal new-onset anger/rejection (AOR 7.064; 95% Cl 2.300-21.700). CONCLUSIONS: The factors associated with new-onset paternal bonding failure from 1 to 6 months postpartum were paternal childcare leave, preterm birth, paternal postpartum depression symptoms, and maternal bonding failure.
Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Social psychiatry and psychiatric epidemiology　58　(11)　1593-1601　2023/06/03

DOI： 10.1007/s00127-023-02498-w 　

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PURPOSE: Studies examining the associations between maternal social relationships and early childhood development have mainly focused on social relationships after childbirth. We aimed to prospectively examine the associations between the transition of maternal social isolation from the prenatal to postnatal period and early childhood development. METHODS: We analyzed data for 6692 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social isolation in the prenatal and postnatal periods was assessed by the Lubben Social Network Scale-abbreviated version and categorized into four groups: none, prenatal only, postnatal only, and both. The Ages and Stages Questionnaire, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between maternal social isolation and developmental delays. RESULTS: The prevalence of social isolation in both the prenatal and postnatal periods was 13.1%. Social isolation in both the prenatal and postnatal periods was associated with developmental delays in children at 2 and 3.5 years of age: the multivariate-adjusted odds ratios (95% confidence intervals) were 1.68 (1.39-2.04) and 1.43 (1.17-1.76), respectively. Social isolation in the prenatal period only and social isolation in the postnatal period only were not associated with developmental delays in children at 2 and 3.5 years of age. CONCLUSION: Maternal social isolation in both the prenatal and postnatal periods was associated with an increased risk of developmental delays in early childhood.
妊婦における精神神経用剤服薬および心理的苦痛の有無と2歳時点の児の行動特性との関連

高橋一平, 小原拓, 菊地紗耶, 小林奈津子, 小原竜, 野田あおい, 上野史彦, 大沼ともみ, 村上慶子, 石黒真美, 富田博秋, 栗山進一

精神神経学雑誌　(2023特別号)　S584-S584　2023/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
出生三世代コホートにおける7人家族のエピゲノム研究基盤構築

美辺詩織, 小巻翔平, 大桃秀樹, 高嶋聰, 小野加奈子, 山崎弥生, 須藤洋一, 田高周, 水野聖士, 石黒真美, 工藤久智, 小原拓, 熊田和貴, 勝岡史城, 荻島創一, 木下賢吾, 菅原準一, 栗山進一, 清水厚志

日本抗加齢医学会総会プログラム・抄録集　23回　252-252　2023/06
Publisher: (一社)日本抗加齢医学会
Associations between sugar-sweetened beverages before and during pregnancy and offspring overweight/obesity in Japanese women: the TMM BirThree Cohort Study. International-journal

Misato Aizawa, Keiko Murakami, Yudai Yonezawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Public health nutrition　26　(6)　1222-1229　2023/06

DOI： 10.1017/S1368980023000307 　

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OBJECTIVE: The association between high sugar-sweetened beverages (SSB) intake during pregnancy and offspring overweight/obesity has been reported only from Western countries. The objective of this study was to examine the association between SSB intake before and during pregnancy and offspring overweight/obesity among Japanese women. DESIGN: Japanese prospective birth cohort study. SETTING: We analysed mother-offspring pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SSB intake during pregnancy was evaluated using the FFQ and classified into three groups: none (0 g/d), medium (<195 g/d) and high (>195 g/d). Overweight or obesity at 1 year of age in offspring was defined as having a BMI Z-score greater than 2 sd, calculated based on the BMI reference data for Japanese children. Multiple logistic regression analyses were performed to examine the associations between SSB intake before and during pregnancy and offspring overweight/obesity, after adjusting for covariates. PARTICIPANTS: Japanese mother-offspring pairs (n 7114). RESULTS: The overweight/obesity rate of the offspring was 8·8 %. Pregnant women with a high intake of SSB in early to mid-pregnancy had a higher risk of overweight/obesity in their offspring compared with those who did not; the OR was 1·52 (95 % CI (1·09, 2·12)). CONCLUSIONS: High SSB intake in early to mid-pregnancy was associated with an increased risk of offspring overweight/obesity at 1 year of age.
Association between being Overweight in Young Childhood and during School Age and Puberty. International-journal

Genki Shinoda, Yudai Nagaoka, Fumihiko Ueno, Naoyuki Kurokawa, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Keiko Murakami, Mami Ishikuro, Taku Obara, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

Children (Basel, Switzerland)　10　(5)　2023/05/22

DOI： 10.3390/children10050909 　

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To examine whether body type at birth, body weight, and obesity in early childhood are associated with overweight/obesity during school age and puberty. Data from maternal and child health handbooks, baby health checkup information, and school physical examination information of participants at birth and three-generation cohort studies were linked. Association between body type and body weight at different time intervals (at birth and at 1.5, 3.5, 6, 11, and 14 years of age) were comprehensively analyzed using a multivariate regression model adjusted for gender, maternal age at childbirth, maternal parity, and maternal body mass index, and drinking and smoking statuses at pregnancy confirmation. Children who are overweight in young childhood had a greater risk of being overweight. Particularly, overweight at one year of age during checkup was associated with overweight at 3.5 years (adjusted odds ratio (aOR), 13.42; 95% confidence interval (CI), 4.46-45.42), 6 years (aOR, 6.94; 95% CI, 1.64-33.46), and 11 years (aOR, 5.22; 95% CI, 1.25-24.79) of age. Therefore, being overweight in young childhood could increase the risk of being overweight and obese during school age and puberty. Early intervention in young childhood may be warranted to prevent obesity during school age and puberty.
Association between low levels of anti-inflammatory cytokines during pregnancy and postpartum depression. International-journal

Chiaki T Ono, Zhiqian Yu, Taku Obara, Mami Ishikuro, Keiko Murakami, Masahiro Kikuya, Saya Kikuchi, Natsuko Kobayashi, Hisaaki Kudo, Soichi Ogishima, Naoko Minegishi, Junichi Sugawara, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Hiroaki Tomita

Psychiatry and clinical neurosciences　77　(8)　434-441　2023/05/13

DOI： 10.1111/pcn.13566 　

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AIM: Previous studies based on a relatively limited number of subjects have indicated potential associations between plasma cytokine concentrations in perinatal women and postpartum depression (PPD). This report aimed to examine alterations in cytokine levels during pregnancy and after delivery by measuring nine cytokines in prenatal and postnatal plasma samples in a large cohort. METHODS: A nested, case-control study was conducted using plasma samples from 247 women with PPD (Edinburgh Postnatal Depression Scale: EPDS ≥9) and 243 age-matched control (EPDS ≤2) women from among perinatal women who participated in the Tohoku Medical Megabank three-generation cohort. Concentrations of nine plasma cytokines (IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, and TNF-α) in plasma collected at the time of enrollment during pregnancy and one month after delivery were determined using an immunoassay kit. RESULTS: Cross-sectional comparisons of cytokine levels during pregnancy and after delivery indicated that the PPD group maintained significantly lower plasma IL-4 levels during pregnancy and after delivery than the control group, and that plasma IL-4 levels decreased significantly during pregnancy regardless of PPD status. Plasma IL-10 levels were significantly higher during pregnancy than after delivery only among healthy controls, and plasma IL-10 levels were significantly higher in the control group than in the PPD group. Moreover, IFN-γ, IL-6, IL-12p40, and TNF-α levels were significantly lower during pregnancy compared with after delivery regardless of PPD status. CONCLUSIONS AND RELEVANCE: These results suggest a potential protective effect of the anti-inflammatory cytokines IL-4 and IL-10 during pregnancy against the development of PPD. This article is protected by copyright. All rights reserved.
Relationship between age-related hearing loss and consumption of coffee and tea.

Gosuke Watarai, Jun Suzuki, Ikuko N Motoike, Miyuki Sakurai, Ryoukichi Ikeda, Tetsuaki Kawase, Kengo Kinoshita, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Masayuki Yamamoto, Yukio Katori

Geriatrics & gerontology international　2023/05/03

DOI： 10.1111/ggi.14589 　
高齢者における尿Na/K比の血圧への影響は非高齢者より大きい

平田匠, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 丹野高三, 寳澤篤

日本老年医学会雑誌　60　(Suppl.)　178-178　2023/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
抑うつ症状と家庭高血圧発症リスクの関連東北メディカル・メガバンク計画地域住民コホート調査

時岡紗由理, 中谷直樹, 中谷久美, 小暮真奈, 千葉一平, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 寳澤篤

日本循環器病予防学会誌　58　(2)　146-146　2023/05
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

BMC pregnancy and childbirth　23　(1)　268-268　2023/04/19

DOI： 10.1186/s12884-023-05603-8 　

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BACKGROUND: Low birth weight is associated with an increased risk of developing chronic diseases in adulthood, with a particularly high incidence in Japan among developed countries. Maternal undernutrition is a risk factor for low birth weight, but the association between the timing of food intake and infant birth weight has not been investigated. This study aimed to examine the association between breakfast intake frequency among Japanese pregnant women and infant birth weight. METHODS: Of all pregnant women who participated in the Tohoku Medical Megabank Project Three Generation Cohort Study, 16,820 who answered the required questions were included in the analysis. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: every day and 5-6, 3-4, and 0-2 times/week. Multivariate linear regression models were constructed to examine the association between breakfast intake frequency among pregnant women and infant birth weight. RESULTS: The percentage of pregnant women who consumed breakfast daily was 74% in the pre- to early pregnancy period and 79% in the early to mid-pregnancy period. The average infant birth weight was 3,071 g. Compared to women who had breakfast daily from pre- to early pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -38.2, 95% confidence interval [CI]: -56.5, -20.0). Similarly, compared to women who had breakfast daily from early to mid-pregnancy, those who had breakfast 0-2 times/week had lower infant birth weight (β = -41.5, 95% CI: -63.3, -19.6). CONCLUSIONS: Less frequent breakfast intake before and mid-pregnancy was associated with lower infant birth weight.
Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of epidemiology　2023/04/08

DOI： 10.2188/jea.JE20220355 　

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BACKGROUND: Although fat mass index (FMI) and fat-free mass index (FFMI) affect lung function, FMI and FFMI are not independent of each other since FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. We aimed to examine the association of combined FMI and FFMI with lung function. METHODS: In this cross-sectional study, lung function was evaluated using forced expiratory volume at 1 s and forced vital capacity was measured using spirometry. Both FMI and FFMI were classified into sex-specific quartiles (16 groups). Analysis of covariance was used to assess the associations of combined FMI and FFMI with lung function. The trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1-4 (lowest-highest), and entering the number as a continuous term in the regression model. RESULTS: This study included 3,736 men and 8,821 women aged ≥20 years living in Miyagi Prefecture, Japan. The mean FEV1 (standard deviation) was 3.0 (0.7) L for men and 2.3 (0.5) L for women. The mean FVC was 3.8 (0.7) L for men and 2.8 (0.5) L for women. The FMI was inversely associated with lung function among all FFMI subgroups in both sexes. Conversely, FFMI was positively associated with lung function in all FMI subgroups in both sexes. CONCLUSIONS: Higher FMI was associated with lower lung function independent of FFMI; higher FFMI was associated with higher lung function independent of FMI. Reducing FMI and maintaining FFMI might be important for respiratory health.
Difficulties in Accessing Medication Records at the Time of a Large-Scale Disaster. International-journal

Fumihiko Ueno, Keiko Murakami, Masato Nagai, Hiroko Matsubara, Tomomi Oonuma, Fumiko Matsuzaki, Aoi Noda, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Disaster medicine and public health preparedness　17　e370　2023/04/05

DOI： 10.1017/dmp.2022.301 　

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OBJECTIVE: In a large-scale disaster, medical professionals need to access medication records and provide medicines to people who cannot return home to take their daily medicines. We investigated the proportion of carrying the paper notebook or availability of the smartphone application of the medication record among people who are assumed to have difficulty in taking their medicines during large-scale disasters. METHODS: In Japan, a web-based survey was conducted in 2018 by randomly selecting adults ≥ 20 years of age. RESULTS: There were 2286 medication record owners in 3082 participants. Of the medication record owners, 784 (34.3%) took medicines that could not be missed for even a day. Among them, 724 used paper notebooks alone, 26 used smartphone applications alone, and 34 used both. Among the 724, 208 (28.8%) always carried a paper notebook. Among the 26, 16 (61.5%) could use their applications anytime. Therefore, among the 784, at least 560 (71.4%) could not always access their medication information. CONCLUSIONS: An awareness campaign to carry paper notebooks and install applications for medication records should be held, since only a limited number of people carry their medication records and always have access to their medication information.
Combination of genetic and environmental factors for childhood hypertension: a simple indicator of family history remains useful. International-journal

Hirohito Metoki, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　1061-1063　2023/04

DOI： 10.1038/s41440-022-01165-y 　
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta Paediatrica, International Journal of Paediatrics　112　(4)　776-778　2023/04

DOI： 10.1111/apa.16662 　

ISSN： 0803-5253

eISSN： 1651-2227
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

ACTA PAEDIATRICA　112　(4)　776-778　2023/04

DOI： 10.1111/apa.16662 　

ISSN： 0803-5253

eISSN： 1651-2227
Weight-for-age z-scores of Japanese children using the World Health Organization Child Growth Standards. International-journal

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta paediatrica (Oslo, Norway : 1992)　112　(4)　776-778　2023/04

DOI： 10.1111/apa.16662 　
Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

European child & adolescent psychiatry　2023/03/30

DOI： 10.1007/s00787-023-02199-4 　

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It is essential to clarify factors associated with mental health and behavioral problems in early childhood, because children are critical stages of life for mental health. We aimed to prospectively examine the associations between maternal social isolation and behavioral problems in preschool children. We analyzed data from 5842 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores < 12) one year after delivery. The Child Behavior Checklist 1½-5 was used to assess behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations between social isolation and behavioral problems, after adjustment for age, education, income, work status, marital status, extraversion, neuroticism, depressive symptoms, child sex, and number of siblings. Multiple logistic regression analyses were also conducted for internalizing problems and externalizing problems. The prevalence of maternal social isolation was 25.4%. Maternal social isolation was associated with an increased risk of behavioral problems in children: the odds ratio (OR) was 1.37 (95% confidence interval [CI] 1.14-1.64). Maternal social isolation was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.33 (95% CI, 1.12-1.59) and 1.40 (95% CI, 1.18-1.66), respectively. In conclusion, maternal social isolation one year after delivery was associated with behavioral problems in children at 4 years of age.
母親における出産前後の社会的孤立と児の発達との関連三世代コホート調査

村上慶子, 野田あおい, 石黒真美, 小原拓, 上野史彦, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

日本衛生学雑誌　78　(Suppl.)　S173-S173　2023/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of women's mental health　26　(2)　219-226　2023/02/21

DOI： 10.1007/s00737-023-01298-0 　

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Although there is some evidence regarding an association between maternal bonding disorder and child development, studies have mainly focused on development during the period of infancy. We aimed to examine the associations between maternal postnatal bonding disorder and developmental delays in children beyond 2 years of age. We analyzed data from 8380 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score of ≥5 at 1 month after delivery. The Ages & Stages Questionnaires, Third Edition, which consists of five developmental areas, was used to assess developmental delays in children at 2 and 3.5 years of age. Multiple logistic regression analyses were conducted to examine the associations between postnatal bonding disorder and developmental delays after adjustment for age, education, income, parity, feelings toward pregnancy, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. Bonding disorder was associated with developmental delays in children at 2 and 3.5 years of age: the odds ratios (95% confidence intervals) were 1.55 (1.32-1.83) and 1.60 (1.34-1.90), respectively. Bonding disorder was associated with delay in communication only at 3.5 years of age. Bonding disorder was associated with delay in gross motor, fine motor, and problem solving, but not delay in the personal-social domain, at 2 and 3.5 years of age. In conclusion, maternal bonding disorder 1 month after delivery was associated with an increased risk of developmental delays in children beyond 2 years of age.
Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2023/02/11

DOI： 10.5551/jat.64039 　

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AIM: We examined the association between the carotid intima medica thickness (cIMT) and risk factors for atherosclerosis based on the Japan Atherosclerosis Society 2022 Atherosclerosis Prevention Guideline. METHODS: Using data from the Tohoku Medical Megabank Community-based Cohort Study, we performed a cross-sectional study that enrolled 13,366 participants (age ≥ 20 years) with an analysis of covariance to assess associations between cIMT and risk factors for atherosclerosis. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. Analysis was conducted in the model adjusted for age, sex, smoking status, drinking status, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), high-density lipoprotein-cholesterol (HDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), and height. RESULTS: In this study cohort, the average age and cIMT were 57.3 (13.8) years and 0.61 (0.13) mm, respectively, which included 3,988 males (29.8%). Males had a higher cIMT than did the females. Age, height, BMI, SBP, HbA1c, and non-HDL-C were positively associated with cIMT. HDL-C was inversely associated with cIMT. Compared with never drinkers, current drinkers (≥ 46.0 g/day) had a significantly decreased cIMT. CONCLUSIONS: The cIMT was associated with atherosclerosis risk factors including age, sex, BMI, SBP, HbA1c, non-HDL-C, and HDL-C, and adequate control of risks in high-risk individuals might be required to prevent atherosclerotic cardiovascular diseases.
Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Journal of paediatrics and child health　59　(3)　548-554　2023/02/08

DOI： 10.1111/jpc.16353 　

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AIM: An association between maternal psychological distress and children's development has been reported, but reports from Japan are limited. This study aimed to examine the association of maternal psychological distress with children's neurodevelopment in Japan. METHODS: The study assessed data of 7646 mother-infant pairs in the Japanese population. We used Kessler Psychological Distress Scale, a screening tool for psychological distress, to assess maternal psychological distress in early pregnancy and 2 years postpartum and divided it into four categories: none in both the pre-natal and post-natal periods, only the pre-natal period, only the post-natal period and both the pre-natal and post-natal periods. Children's neurodevelopment was assessed using the Ages & Stages Questionnaires Third Edition (ASQ-3) at 4 years of age. ASQ-3 comprises five domains (communication, gross motor, fine motor, problem solving and personal-social), and the score of less than -2 standard deviation relative to the mean in reference was defined as having developmental delay. We conducted multivariate logistic regression analysis to examine the association between maternal psychological distress and children's neurodevelopment. RESULTS: The prevalence of developmental delay of communication, gross motor, fine motor, problem solving and personal-social were 4.0%, 4.3%, 4.9%, 3.8% and 4.6%, respectively. Maternal psychological distress in only the postpartum period and both pre-natal and postpartum periods were associated with risks of developmental delay in all domains. Maternal psychological distress in only the pre-natal period was associated with developmental delay in communication. CONCLUSIONS: Maternal psychological distress is associated with risks of children's developmental delay.
Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children's Study. International-journal

Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Kaoh Tanoue, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　46　(4)　834-844　2023/02/03

DOI： 10.1038/s41440-022-01144-3 　

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Hypertensive disorders of pregnancy (HDP) are associated with poor maternal and neonatal prognoses. Although several studies have indicated an effect of secondhand smoke (SHS) exposure on HDP, such evidence is lacking in Japan. Therefore, we analyzed data from the Japan Environment and Children's Study, a large-scale epidemiological investigation, to elucidate a possible link between SHS exposure and HDP risk. Data were obtained from the all-birth fixed datasets and included information on 104,062 fetuses and their parents. SHS exposure was assessed in terms of the frequency (rarely, 1-3, or 4-7 days/week) and the daily duration of exposure (<1, 1-2, or ≥2 h(s)/day). Modified Poisson regression model analyses were performed with adjustment for known risk factors for HDP. Additionally, the population attributable fractions (PAFs) of SHS exposure and maternal smoking to HDP prevalence were estimated. The relative risks of developing HDP among individuals with SHS exposures of 4-7 days/week and ≥2 h/day were 1.18 and 1.27 (95% confidence interval: 1.02-1.36 and 0.96-1.67), respectively, compared to the reference groups (rare exposure and <1 h/day). The PAFs for the risk of HDP due to SHS exposure and perinatal smoking were 3.8% and 1.8%, respectively. Japanese women with greater exposure to SHS have a higher risk of HDP after adjustment for possible confounding factors; thus, relevant measures are required to reduce SHS exposure to alleviate HDP risk. The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4-7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.
乳幼児期のRSウイルス感染の重症化と喘鳴との関連東北メディカル・メガバンク計画三世代コホート調査

上野史彦, 松崎芙美子, 中山慶一, 百瀬敦, 落合秀和, 石黒真美, 村上慶子, 野田あおい, 大沼ともみ, 小原拓, 菅原準一, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　136-136　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
妊婦の朝食摂取頻度と児の出生体重との関連東北メディカル・メガバンク計画三世代コホート調査

相澤美里, 村上慶子, 高橋一平, 大沼ともみ, 野田あおい, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 濱田裕貴, 岩間憲之, 齋藤昌利, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　100-100　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
診察室非高血圧者における抑うつ気分と仮面高血圧の関連性の検討

時岡紗由理, 中谷直樹, 千葉一平, 中谷久美, 小暮真奈, 畑中里衣子, 菅野郁美, 小原拓, 栗山進一, 辻一郎

Journal of Epidemiology　33　(Suppl.1)　141-141　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
BMI・飲酒・尿Na/K比と高血圧の関連における両親の高血圧既往の影響

平田匠, 小暮真奈, 畑中里衣子, 千葉一平, 中谷久美, 菅野郁美, 中村智洋, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　155-155　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
脂肪量指数と除脂肪量指数の組み合わせと呼吸機能検査指標の関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　155-155　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
糖尿病指標と嗅覚機能の関連

佐竹芽久美, 菅野郁美, 佐藤守一, 今枝孝夫, 高梨昌樹, 早川和美, 中谷久美, 千葉一平, 小暮真奈, 畑中里衣子, 斉藤智, 中村智洋, 長神風二, 荻島創一, 布施昇男, 麦倉俊司, 栗山進一, 中谷直樹, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　156-156　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画地域住民コホート調査(宮城)詳細二次調査の概要

中谷久美, 中谷直樹, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 中村智洋, 小原拓, 宇留野晃, 布施昇男, 辻一郎, 栗山進一, 寳澤篤

Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
母親の社会的孤立と児の問題行動の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 石黒真美, 小原拓, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 高橋一平, 菊地紗耶, 小林奈津子, 濱田裕貴, 岩間憲之, 目時弘仁, 菊谷昌浩, 齋藤昌利, 菅原準一, 富田博秋, 八重樫伸生, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　92-92　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
一般成人における24時間思い出しWeb食事調査による栄養素等摂取量推定の妥当性

中舘美佐子, 石原淳子, 高地リベカ, 菅原詩緒理, 保科由智恵, 鬼頭久美子, 小手森綾香, 丸谷幸子, 荻野麻子, 鈴木碧, 小原拓, 石黒真美, 野田あおい, 相澤美里, 高橋一平, 米沢祐大, 山下貴宏, 鈴木重徳, 村上慶子, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　100-100　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
複数回のFFQによる栄養素等摂取量推定の妥当性東北メディカル・メガバンク計画コホート調査妥当性研究

荻野麻子, 高地リベカ, 石原淳子, 菅原詩緒理, 保科由智恵, 鬼頭久美子, 中舘美佐子, 丸谷幸子, 鈴木碧, 小原拓, 石黒真美, 上野史彦, 野田あおい, 相澤美里, 高橋一平, 米沢祐大, 山下貴宏, 鈴木重徳, 村上慶子, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　101-101　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Weight‐for‐age z ‐scores of Japanese children using the World Health Organization Child Growth Standards

Masayuki Kobayashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama

Acta Paediatrica　112　(4)　776-778　2023/01/17
Publisher: Wiley
DOI： 10.1111/apa.16662 　

ISSN： 0803-5253

eISSN： 1651-2227
Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Fumiko Matsuzaki, Ippei Takahashi, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　325　582-587　2023/01/12

DOI： 10.1016/j.jad.2023.01.044 　

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BACKGROUND: Although there is some evidence that maternal perinatal mental disorders are associated with emotional/behavioral problems in children, the long-term impacts of postnatal bonding disorder remain unclear. We aimed to examine the associations between maternal postnatal bonding disorder and emotional/behavioral problems in preschool children. METHODS: We analyzed data from 7220 mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Maternal bonding disorder was defined as Mother-to-Infant Bonding Scale score ≥5 at 1 month after delivery. The Child Behavior Checklist 1½-5 was used to assess emotional/behavioral problems, and its subscales were used to assess internalizing and externalizing problems in children at 4 years of age. Multiple logistic regression analyses were conducted to examine the associations of postnatal bonding disorder with emotional/behavioral, internalizing, and externalizing problems after adjustment for age, education, income, parity, prenatal psychological distress, postnatal depressive symptoms, child's sex, preterm birth, and birth defects. RESULTS: The prevalence of postnatal bonding disorder was 14.8 %. Postnatal bonding disorder was associated with an increased risk of emotional/behavioral problems in children: the odds ratio (OR) was 2.06 (95 % confidence interval [CI], 1.72-2.46). Postnatal bonding disorder was also associated with increased risks of internalizing problems and externalizing problems in children: the ORs were 1.69 (95 % CI, 1.42-2.02) and 1.90 (95 % CI, 1.59-2.26), respectively. LIMITATIONS: Bonding and problems were self-reported. CONCLUSIONS: Bonding disorder at 1 month after delivery was associated with an increased risk of emotional/behavioral problems in children at 4 years of age.
Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019. International-journal

Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

Pregnancy hypertension　31　73-83　2023/01/09

DOI： 10.1016/j.preghy.2023.01.001 　

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OBJECTIVES: To evaluate the major congenital malformation (MCM) risk of first-trimester antihypertensive exposure, specifically of amlodipine and methyldopa. STUDY DESIGN: A large administrative claims database was used. MAIN OUTCOME MEASURES: The prevalence of antihypertensive prescriptions during pregnancy was described in 91,390 women giving birth between 2010 and 2019. The MCM risk of first-trimester antihypertensives was evaluated in 1,185 women diagnosed with hypertensive disorders in the first trimester. The MCM risk of first-trimester amlodipine and methyldopa was evaluated in 178 women who were prescribed antihypertensives in the first trimester. RESULTS: Antihypertensives were prescribed to 278 (0.30%) women during their first trimester. The prescription prevalence in the first trimester was highest for methyldopa (115, 0.13%), followed by amlodipine (55, 0.06%). Antihypertensives were prescribed to 2,955 (3.23%) women during pregnancy. Nifedipine (903, 0.99%) and nicardipine (758, 0.83%) were the most frequently prescribed oral and injectable antihypertensives during pregnancy, both with a significant increase in annual prevalence. Of the 1,185 women diagnosed with hypertensive disorders in the first trimester, antihypertensives were prescribed to 178 women. The adjusted odds ratio (aOR) of MCMs in the first-trimester prescription of any antihypertensive medication was 1.124 (95% confidence interval [CI], 0.618-2.045). Amlodipine and methyldopa were prescribed to 44 and 93 of the 178 women, respectively. The aORs of MCMs in the first-trimester prescription of amlodipine and methyldopa were 1.219 (95% CI, 0.400-3.721) and 0.921 (0.331-2.564), respectively. CONCLUSIONS: The MCM risk of first-trimester exposure to antihypertensives, including amlodipine and methyldopa, was not suggested.
Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. International-journal

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of hypertension　41　(3)　443-52　2023/01/04

DOI： 10.1097/HJH.0000000000003356 　

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BACKGROUND: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home hypertension. We investigated the associations between lung function and hypertension in a Japanese population. INDIVIDUALS AND METHODS: We conducted a cross-sectional study of 3728 men and 8795 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was assessed using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC), measured by spirometry. Hypertension was defined as a casual blood pressure at least 140/90 mmHg and/or self-reported treatment for hypertension. Home hypertension was defined as morning home blood pressure at least 135/85 mmHg and/or self-reported treatment for hypertension. Multivariate logistic regression models adjusted for potential confounders were used to assess the association between lung function and hypertension. RESULTS: The mean ages (±SD) of men and women were 60.1 (±14.0) years and 56.2 (±13.4) years, respectively, and 1994 (53.5%) men and 2992 (34.0%) women had hypertension. In the multivariable models, FEV1 and FVC were inversely associated with hypertension. Inverse associations between lung function and hypertension were observed even among never-smokers. Furthermore, reduced lung function was associated with higher prevalence of home hypertension in men and women. CONCLUSION: Reduced lung function was associated with higher prevalence of hypertension, independent of smoking status. Assessment of the lung function or blood pressure may be required in individuals with reduced lung function or hypertension.
Factors associated with postpartum smoking relapse at early postpartum period of Japanese women in the Japan Environmental and Children's Study.

Akane Anai, Kaname Asato, Nozomi Tatsuta, Kasumi Sakurai, Chiharu Ota, Shinichi Kuriyama, Junichi Sugawara, Takahiro Arima, Nobuo Yaegashi, Kunihiko Nakai

Environmental health and preventive medicine　28　56-56　2023

DOI： 10.1265/ehpm.23-00059 　

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BACKGROUND: Postpartum smoking relapse is a serious public health concern. Previous studies have identified several risk factors for postpartum smoking relapse; however, very little is known about the predictors of early postpartum smoking relapse. This study aimed to determine postpartum smoking relapse status and its associated risk factors at 1 month postpartum among Japanese women. METHODS: Data were obtained from 93,851 mothers with live births in an ongoing birth cohort study, the Japan Environment and Children's Study. Data on smoking status and confounding variables were collected using self-administered questionnaires and medical record transcripts. Self-administered questionnaires were administered during the first trimester, second/third trimester, and 1 month after delivery. A multiple logistic regression analysis was performed. RESULTS: Among the 14,326 mothers who smoked during pregnancy, 10,917 (76.2%) quit smoking during pregnancy. Subsequently, 617 (5.7%) of the mothers who had quit relapsed smoking at 1 month postpartum. Maternal age (≤24, ≥35), maternal education (≤12 years), parity (≥Second), feeding method (Formula milk), partner smoking status during pregnancy (Smoker), number of cigarettes per day before the cessation of smoking (≥11), maternal alcohol consumption at 1-month postpartum (Drinker), postpartum depression (EPDS score ≥9), and spending time at the parents' home after delivery (≥14 days) were associated with smoking relapse. CONCLUSIONS: A certain number of mothers relapsed even 1 month postpartum. Besides mother's alcohol and smoking habit before pregnancy, breastfeeding and partner smoking are important factors in early postpartum smoking relapse in Japan.
A knowledge representation model for family relationship to three generation Peer-reviewed

Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, Satoshi Mizuno, Satoshi Nagaie, Masato Nagai, Chizuru Yamanaka, Hiroko Matsubara, Mayumi Kato, Yuki Sato, Soichi Ogishima, Takako Takai, Masahiro Kikuya, Atsushi Hozawa, Fuji Nagami, Shinichi Kuriyama, Takashi Suzuki, Kengo Kinoshita, Masayuki Yamamoto, Hiroshi Tanaka

Bioinformation　18　(12)　1166-1172　2022/12/31
Publisher: Biomedical Informatics
DOI： 10.6026/973206300181166 　

ISSN： 0973-8894

eISSN： 0973-2063

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A system for inputting and storing family information, named “BirThree Enrollment,” was developed to promote a birth and three-generation cohort study (BirThree Cohort Study). In this cohort study, it was necessary to satisfy many operational demands while constantly overwriting and changing input information. Complex kinship information must be quickly and accurately inputed and corrected, and information on those families not yet recruited must be retrieved. For these purposes, many devices are needed, from an input interface to the internal data structure. In the field of genetic statistics, a simple standard expressive form (describe father-child relation and mother-child relation) is used for describing family structure. However, this form doesn't have sufficient information. So we developed a new form in conducting the BirThree Cohort Study. Hence, we expanded the data structure, and constructed the Input control system. Family pedigree information is stored along with initial clinical information, and this enabled the input of all self-reported information to the data base. Operators are able to input this family information before the day is out. As a result, when recruitment is completed, family information will be completed concurrently. Therefore, operators can immediately know certain person's family structure. In this model data correction was improved dramatically, and the system was operated successfully. This study is the first report of the method for storing three generations of family data.
Dietary calcium intake was related to the onset of pre-eclampsia: The TMM BirThree Cohort Study. International-journal

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Ippei Takahashi, Fumiko Matsuzaki, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

Journal of clinical hypertension (Greenwich, Conn.)　25　(1)　61-70　2022/12/28

DOI： 10.1111/jch.14606 　

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This study aimed to explore the relationship between dietary electrolyte intake and the prevalence of hypertensive disorders of pregnancy (HDP) subtypes. Our analysis included 19 914 pregnant women from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. A food frequency questionnaire was used to estimate dietary calcium, potassium, sodium, and magnesium intakes. HDP was determined based on the medical records during regular antenatal care. Logistic regression analysis assessed the relationship between dietary electrolytes intake quintiles, and HDP subtypes with adjustment for basic characteristics. Dietary electrolyte intakes were applied for the prediction model. Of the cohort, 547 participants delivered with pre-eclampsia (PE), 278 with superimposed PE (SP), and 896 with gestational hypertension (GH). PE was associated with low crude calcium intake (odds ratio of the first quintile [<251 mg/day] to the fifth quintile [>623 mg/day] and 95% confidence interval, 1.31 [1.00-1.70]) and P for trend was .02. SP was not associated with any nutritional intake; however, the combined outcome of PE and SP was related to low crude calcium and potassium and energy-adjusted calcium, potassium, and magnesium intakes (P for trend, .01, .048, .02, .04, and .02, respectively). The same tendency was observed for GH. A prediction model that included crude calcium and potassium intakes performed better than a model without them. In conclusion, low dietary calcium, potassium, and magnesium were associated with higher HDP subtypes prevalence. The prediction model implied that crude calcium and potassium intakes might play a critical role in PE and SP pathogenesis.
Plasma metabolic disturbances during pregnancy and postpartum in women with depression. International-journal Peer-reviewed

Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N Motoike, Chiaki Ono, Yasunobu Okamura, Tomomi Onuma, Yuta Takahashi, Mai Sakai, Hisaaki Kudo, Taku Obara, Keiko Murakami, Matusyuki Shirota, Saya Kikuchi, Natsuko Kobayashi, Yoshie Kikuchi, Junichi Sugawara, Naoko Minegishi, Soichi Ogishima, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Seizo Koshiba, Hiroaki Tomita

iScience　25　(12)　105666-105666　2022/12/22

DOI： 10.1016/j.isci.2022.105666 　

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Examining plasma metabolic profiling during pregnancy and postpartum could help clinicians understand the risk factors for postpartum depression (PPD) development. This analysis targeted paired plasma metabolites in mid-late gestational and 1 month postpartum periods in women with (n = 209) or without (n = 222) PPD. Gas chromatogram-mass spectrometry was used to analyze plasma metabolites at these two time points. Among the 170 objected plasma metabolites, principal component analysis distinguished pregnancy and postpartum metabolites but failed to discriminate women with and without PPD. Compared to women without PPD, those with PPD exhibited 37 metabolites with disparate changes during pregnancy and the 1-month postpartum period and an enriched citrate cycle. Machine learning and multivariate statistical analysis identified two or three compounds that could be potential biomarkers for PPD prediction during pregnancy. Our findings suggest metabolic disturbances in women with depression and may help to elucidate metabolic processes associated with PPD development.
Antihypertensive drug use during pregnancy in Japan. International-journal

Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Keiko Murakami, Shinichi Kuriyama

Hypertension research : official journal of the Japanese Society of Hypertension　46　(2)　548-549　2022/12/02

DOI： 10.1038/s41440-022-01101-0 　
Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project.

Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Tomomi Onuma, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Akira Uruno, Junichi Sugawara, Kichiya Suzuki, Eiichi N Kodama, Yohei Hamanaka, Naho Tsuchiya, Mana Kogure, Naoki Nakaya, Makiko Taira, Mika Sakurai-Yageta, Toru Tamahara, Junko Kawashima, Maki Goto, Akihito Otsuki, Ritsuko Shimizu, Soichi Ogishima, Hiroaki Hashizume, Fuji Nagami, Tomohiro Nakamura, Atsushi Hozawa, Tadao Kobayashi, Nobuo Fuse, Shinichi Kuriyama, Shigeo Kure, Masayuki Yamamoto

The Tohoku journal of experimental medicine　259　(2)　93-105　2022/12/01

DOI： 10.1620/tjem.2022.J103 　

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The Tohoku Medical Megabank Project (TMM) has been conducting a birth and three-generation cohort study (the BirThree Cohort Study). We recruited 73,529 pregnant women and their family members for this cohort study, which included 23,143 newborns and 9,459 of their siblings. We designed and are in the process of conducting three-step health assessments for each newborn at approximately ages of 5, 10 and 16. These health assessments are administered at seven community support centers. Trained genome medical research coordinators conduct physical examinations of and collect biological specimens from each participant. The Sendai Children's Health Square has been established as the headquarters for these child health assessments and is utilized to accumulate knowledge that can facilitate the proper practice of child health assessments. We designed all the relevant health assessments facilities to allow parents and their children to participate in the health assessments concomitantly. Our centers serve as places where child participants and their parents can feel at ease as a result of the implementation of safety measures and child hospitality measures. The TMM BirThree Cohort Study is in the process of conducting strategically detailed health assessments and genome analysis, which can facilitate studies concerning the gene-environment interactions relevant to noncommunicable diseases. Through these operations, our study allows for a significant depth of data to be collected in terms of the number of biospecimens under study and the comprehensiveness of both basic and clinical data alongside relevant family information.
Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study. International-journal Peer-reviewed

Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Fumiko Matsuzaki, Mami Ishikuro, Taku Obara, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

Nutrition journal　21　(1)　71-71　2022/11/17

DOI： 10.1186/s12937-022-00822-9 　

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BACKGROUND: Hypertensive disorders of pregnancy (HDP) adversely affect the prognosis of mother and child, and the prognosis depends on the subtype of HDP. Skipping breakfast may be associated with increased blood pressure due to disruption of the circadian clock, but the association with the development of HDP has not been studied. The purpose of this study was to examine the association between skipping breakfast and the development of HDP and HDP subtypes in Japanese pregnant women. METHODS: Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 18,839 who answered the required questions were included in the analysis. This study had a cross-sectional design. The breakfast intake frequency from pre-pregnancy to early pregnancy was classified into four groups: daily, 5-6 times per week, 3-4 times per week, and 0-2 times per week. HDP was classified into gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and severe preeclampsia (SuPE). Multiple logistic regression analysis and multinomial logistic analysis were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for breakfast intake frequency and development of HDP or HDP subtypes. We performed a stratified analysis based on energy intake. RESULTS: Of the participants, 74.3% consumed breakfast daily, and 11.1% developed HDP. Women who consumed breakfast 0-2 times per week had a higher risk of HDP (OR: 1.33, 95% CI: 1.14-1.56), CH (OR: 1.63, 95% CI: 1.21-2.19), and PE (OR: 1.68, 95% CI: 1.27-2.21) than those who consumed breakfast daily. No association was found between skipping breakfast and the risk of developing GH (OR: 1.26, 95% CI: 0.99-1.61) and SuPE (OR: 0.91, 95% CI: 0.55-1.49). Stratified analysis showed that the risk of developing HDP due to skipping breakfast was highest in the group with the highest daily energy intake. CONCLUSIONS: Skipping breakfast during pre-to early pregnancy is associated with the development of HDP. Further longitudinal studies are required to clarify the causal association between skipping breakfast and HDP.
Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal Peer-reviewed

Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, Ayaka Igarashi, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama

BMC psychiatry　22　(1)　693-693　2022/11/11

DOI： 10.1186/s12888-022-04330-2 　

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BACKGROUND: Childcare facilities are a factor that lowers the established association of mother's postnatal psychiatric symptoms with children's behavioral problems. However, no studies have considered the prenatal psychiatric symptoms yet. This study examined whether the use of childcare facilities moderates the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years. METHODS: The present study was based on the data from 23,130 mother-child pairs participating in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. K6 was used to classify maternal psychological distress in early pregnancy and at two years postpartum into four categories: none in both prenatal and postnatal periods (none), only the prenatal period (prenatal only); only the postnatal period (postnatal only); both prenatal and postnatal periods (both). The children's behavioral problems were assessed using the Child Behavior Checklist for Ages 1½-5 (CBCL) aged four years. The clinical range of the externalizing, internalizing, and total problem scales of the CBCL was defined as having behavioral problems. To examine whether availing childcare facilities moderates the association between maternal psychological distress and children's behavioral problems, we conducted a stratified analysis based on the use of childcare facilities or not, at two years of age. The interaction term between maternal psychological distress and use of childcare facilities was included as a covariate in the multivariate logistic regression analysis to confirm the p-value for the interaction. RESULTS: The prevalence of the clinical ranges of externalizing problems, internalizing problems, and clinical range of total problems were 13.7%, 15.4%, and 5.8%, respectively. The association of maternal psychological distress with a high risk of children's behavioral problems was significant; however, the association between prenatal only psychological distress and externalizing problems in the group that did not use childcare facilities was not significant. Interactions between the use of childcare facilities and maternal psychological distress on behavioral problems in children were not significant. CONCLUSIONS: Use of childcare facilities did not moderate the association of maternal psychological distress in early pregnancy and at two years postpartum with behavioral problems in children aged four years.
The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Tomoko Kobayashi, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　2022/11/04

DOI： 10.5551/jat.63826 　

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AIM: Impaired lung function is associated with atherosclerotic vascular events. Carotid intima-media thickness (cIMT) is a marker for subclinical atherosclerosis. However, few studies have examined the association between lung function and cIMT among never smokers or individuals stratified by age. We investigated the association between lung function and cIMT in the Japanese population. METHODS: We conducted a cross-sectional study of 3,716 men and 8,765 women aged 20 years or older living in Miyagi Prefecture, Japan. Lung function was evaluated using forced expiratory volume at 1 s (FEV1) and forced vital capacity (FVC) was measured using spirometry. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between lung function and cIMT and adjusted for potential confounders. A linear trend test was conducted by scoring the categories from 1 (lowest) to 4 (highest) and entering the score as a continuous term in the regression model. RESULTS: After adjusting for potential confounders including passive smoking, lower FEV1 and FVC were associated with higher cIMT in both men and women (P＜0.001 for linear trend). This association was confirmed even when we restricted our study to never smokers. Furthermore, even when we stratified by age, an inverse association between lung function and cIMT was confirmed in middle-aged (40-64 years) and elderly participants (65-74 years). CONCLUSIONS: Lower lung function was associated with higher cIMT in the Japanese population independent of age and smoking. Assessment of atherosclerosis or lung function may be required for individuals with lower lung function or atherosclerosis.
Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan. International-journal

Naoki Nakaya, Kumi Nakaya, Naho Tsuchiya, Toshimasa Sone, Mana Kogure, Rieko Hatanaka, Ikumi Kanno, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Shinichi Kuriyama

BMC public health　22　(1)　1978-1978　2022/10/28

DOI： 10.1186/s12889-022-14348-6 　

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BACKGROUND: Previous observational studies have shown similarities in cardiometabolic risk factors between spouses. It is still possible that this result reflects the age similarity of spouses rather than environmental factors of spouses (e.g. cohabitation effect). To clarify the importance of mate cardiometabolic risk factors for similarity of environmental factors, it is necessary to examine whether they are observed in random male-female pairs while maintaining the age of the spousal pairs. This study aimed to determine whether the similarities found between spousal pairs for cardiometabolic risks were also observed between random male-female pairs. METHODS: This cross-sectional study included 5,391 spouse pairs from Japan; data were obtained from a large biobank study. For pairings, women of the same age were randomly shuffled to create new male-female pairs of the same age as that of the original spouse pairs. Similarities in cardiometabolic risk factors between the random male-female pairs were analysed using Pearson's correlation or age-adjusted logistic regression analyses. RESULTS: The mean ages of the men and women were 63.2 and 60.4 years, respectively. Almost all cardiometabolic risk factors similarities were not noted in cardiometabolic risk factors, including the continuous risk factors (anthropometric traits, blood pressure, glycated haemoglobin level, and lipid traits); lifestyle habits (smoking, drinking, and physical activity); or diseases (hypertension, type 2 diabetes mellitus, and metabolic syndrome) between the random male-female pairs. The age-adjusted correlation coefficients ranged from - 0.007 for body mass index to 0.071 for total cholesterol. The age-adjusted odds ratio (95% confidence interval) for current drinkers was 0.94 (0.81 - 1.09); hypertension, 1.07 (0.93 - 1.23); and type 2 diabetes mellitus, 1.08 (0.77 - 1.50). CONCLUSION: In this study, few similarities in cardiometabolic risk factors were noted among the random male-female pairs. As spouse pairs may share environmental factors, intervention strategies targeting lifestyle habits and preventing lifestyle-related diseases may be effective.
Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Sleep health　8　(6)　714-720　2022/10/10

DOI： 10.1016/j.sleh.2022.08.007 　

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OBJECTIVES: To estimate the prevalence of insomnia and examine the association between social isolation and insomnia among pregnant women. METHODS: This cross-sectional study was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Pregnant women were recruited at obstetric clinics and hospitals in Miyagi Prefecture, Japan. We analyzed 17,586 women who completed the questionnaires and were allowed to transcribe medical records. Insomnia was defined as the Athens Insomnia Scale score of ≥6. The Lubben Social Network Scale-abbreviated version was used to assess social isolation (defined as scores <12), and its subscales were used to assess marginal family ties and marginal friendship ties. Multiple logistic regression analyses were conducted to examine the association between social isolation and insomnia during pregnancy, adjusting for age, parity, prepregnancy body mass index, feelings toward pregnancy, education, income, work status, morning sickness, and psychological distress. Multiple logistic regression analyses were also conducted for marginal family ties and marginal friendship ties. RESULTS: The prevalence of insomnia in the second trimester was 37.3%. Women who were socially isolated were more likely to have insomnia than women who were socially integrated: the multivariate-adjusted odds ratio (OR) was 1.26 (95% confidence interval [CI], 1.16-1.36). Marginal family ties and marginal friendship ties were also associated with increased risks of insomnia: the multivariate-adjusted ORs were 1.40 (95% CI, 1.25-1.56) and 1.15 (95% CI, 1.07-1.24), respectively. CONCLUSIONS: Social isolation from family and friends was associated with increased risks of insomnia among pregnant women.
妊娠中の降圧薬使用による血圧管理状況と児のSGAとの関連

石黒真美, 小原拓, 野田あおい, 上野史彦, 松崎芙実子, 大沼ともみ, 村上慶子, 菊谷昌浩, 目時弘仁, 菅原準一, 栗山進一

DOHaD研究　10　(2)　68-68　2022/10
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
東北メディカル・メガバンク計画三世代コホート調査概要と進捗

小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 中谷直樹, 寳澤篤, 菅原準一, 栗山進一

DOHaD研究　10　(2)　80-80　2022/10
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
妊婦に対する抗菌薬処方の実態レセプトデータベースに基づく検討

森下啓, 石川智史, 小原竜, 野田あおい, 松崎芙実子, 石黒真美, 眞野成康, 栗山進一, 小原拓

DOHaD研究　10　(2)　79-79　2022/10
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
魚の摂取頻度と月経痛の有病率の長期的検討エコチル調査における宮城ユニットセンター追加調査

横山絵美, 武田卓, 渡邉善, 岩間憲之, 佐藤倫広, 村上任尚, 櫻井香澄, 志賀尚美, 龍田希, 齋藤昌利, 立花眞仁, 有馬隆博, 栗山進一, 目時弘仁, 八重樫伸生

日本女性医学学会雑誌　30　(1)　125-125　2022/10
Publisher: (一社)日本女性医学学会
ISSN： 2185-8861
Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Journal of affective disorders　320　461-467　2022/09/30

DOI： 10.1016/j.jad.2022.09.139 　

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BACKGROUND: Natural disasters can have serious mental health consequences. We aimed to examine the long-term effects of the 2011 Great East Japan Earthquake (GEJE) on postpartum depressive symptoms (PDS). METHODS: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women in Miyagi Prefecture from 2013 to 2016. Data from 11,403 participants were used in this study. Women were asked about their traumatic experiences of the GEJE with questions addressing threat, witness, and loss. PDS were defined as Edinburgh Postnatal Depression Scale score ≥9 at 1 month after delivery. Multiple logistic regression analyses were conducted to examine the associations of different traumatic experiences of the GEJE and number of traumatic experiences with PDS, after adjustment for age, parity, feelings toward pregnancy, education, income, social isolation, house damage caused by the GEJE, and survey year. RESULTS: About two-fifths of women had at least one traumatic experience of the GEJE. The prevalence of PDS at 1 month after delivery was 13.3 %. Life-threatening experience and witnessing another person's actual or threatened death were associated with PDS: the odds ratios (ORs) were 1.40 (95 % confidence interval [CI], 1.24-1.59) and 1.28 (95 % CI, 1.08-1.53), respectively. Loss of close person was not associated with PDS: the OR was 1.13 (95 % CI, 0.99-1.30). Larger number of traumatic experiences of the GEJE was associated with increased risk of PDS (p for trend <0.001). LIMITATIONS: PDS was self-reported. CONCLUSIONS: Traumatic experiences of the GEJE prior to pregnancy were associated with increased risks of PDS.
Liver steatosis and fibrosis markers' association with cardiovascular and renal damage in Japanese adults: the TMM BirThree cohort study. International-journal

Toshiya Machida, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Jun Inoue, Shinichi Kuriyama, Nariyasu Mano

Annals of hepatology　28　(1)　100761-100761　2022/09/27

DOI： 10.1016/j.aohep.2022.100761 　

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INTRODUCTION AND OBJECTIVES: Patients with non-alcoholic fatty liver disease (NAFLD) are at risk for cardiovascular and chronic kidney diseases. Liver steatosis and fibrosis were assessed using the fatty liver index and fibrosis-4 index, respectively. This study aimed to examine the association between these two parameters in patients with atherosclerosis and chronic kidney disease. METHODS: The two parameters were calculated for 11,867 adults who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Intima-media thickness and estimated glomerular filtration rate were also measured. Logistic regression models were used to estimate the odds ratios (OR). RESULTS: Overall, 4,257 (35.9%) and 4,733 (39.9%) participants had a higher probability of liver steatosis and fibrosis, respectively. The adjusted OR of higher fatty liver index compared to lower fatty liver index for atherosclerosis and chronic kidney disease were 0.98 (95% confidence interval [CI], 0.77-1.24) and 1.79 (95% CI, 1.19-2.69), and those of higher FIB-4 compared to lower FIB-4 were 1.03 (95% CI, 0.82-1.30) and 0.79 (95% CI, 0.52-1.19) for atherosclerosis and chronic kidney disease, respectively. CONCLUSIONS: A higher FLI was associated with CKD independent of other risk factors. Further research is required to identify the causal relationship between liver fat accumulation and CKD.
Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology. International-journal

Akihito Otsuki, Yasunobu Okamura, Noriko Ishida, Shu Tadaka, Jun Takayama, Kazuki Kumada, Junko Kawashima, Keiko Taguchi, Naoko Minegishi, Shinichi Kuriyama, Gen Tamiya, Kengo Kinoshita, Fumiki Katsuoka, Masayuki Yamamoto

Communications biology　5　(1)　991-991　2022/09/20

DOI： 10.1038/s42003-022-03953-1 　

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Long-read sequencing technology enable better characterization of structural variants (SVs). To adapt the technology to population-scale analyses, one critical issue is to obtain sufficient amount of high-molecular-weight genomic DNA. Here, we propose utilizing activated T lymphocytes, which can be established efficiently in a biobank to stably supply high-grade genomic DNA sufficiently. We conducted nanopore sequencing of 333 individuals constituting 111 trios with high-coverage long-read sequencing data (depth 22.2x, N50 of 25.8 kb) and identified 74,201 SVs. Our trio-based analysis revealed that more than 95% of the SVs were concordant with Mendelian inheritance. We also identified SVs associated with clinical phenotypes, all of which appear to be stably transmitted from parents to offspring. Our data provide a catalog of SVs in the general Japanese population, and the applied approach using the activated T-lymphocyte resource will contribute to biobank-based human genetic studies focusing on SVs at the population scale.
Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masahiro Kikuya, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Archives of Women's Mental Health　2022/09/17
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s00737-022-01266-0 　

ISSN： 1434-1816

eISSN： 1435-1102
Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study

Takahiro Yamashita, Taku Obara, Yudai Yonezawa, Ippei Takahashi, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Noriyuki Iwama, Hirotaka Hamada, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Masatoshi Saito, Nobuo Yaegashi, Shinichi Kuriyama

Nutrition Journal　21　(1)　2022/09/16
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12937-022-00808-7 　

eISSN： 1475-2891

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Abstract Background Although small for gestational age (SGA) is a serious problem worldwide, the association of dietary patterns before and during pregnancy with SGA risk is unclear. We evaluated this association among Japanese pregnant women using three methods: reduced rank regression (RRR) and partial least squares (PLS), methods for extracting dietary patterns that can explain the variation of response variables, and principal component analysis (PCA), a method for extracting dietary patterns of the population. Methods Between July 2013 and March 2017, 22,493 pregnant women were recruited to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a population-based prospective birth cohort study in Japan. Information on dietary intake was obtained using food frequency questionnaires, and dietary patterns were extracted using RRR, PLS, and PCA. Information on birth weight was obtained from obstetric records, and the birth weight SD score and SGA were defined by the method of the Japan Pediatric Society. The associations of dietary patterns with birth weight SD score and SGA risk were investigated using multiple linear regression and multiple logistic regression, respectively. Results A total of 17,728 mother-child pairs were included. The birth weight SD score was 0.15 ± 0.96, and the prevalence of SGA was 6.3%. The dietary patterns extracted by RRR and PLS were similar and characterized by a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages in both pre- to early pregnancy and from early to mid-pregnancy. Higher adoption of the RRR and PLS patterns in both periods was associated with an increased birth weight SD score and lower risk of SGA. In contrast, the PCA1 pattern was not associated with birth weight SD score or SGA risk in either period. Although the PCA2 pattern was associated with increased birth weight SD score from early to mid-pregnancy, no other associations with birth weight SD score or SGA risk were observed. Conclusions The dietary pattern with a high intake of cereals and fruits and a low intake of alcoholic and non-alcoholic beverages before and during pregnancy was associated with a decreased SGA risk in Japan.
過敏性腸症候群の有病に関連する要因の検討 TMM計画地域住民コホート調査

中谷久美, 中谷直樹, 永家聖, 小暮真奈, 畑中里衣子, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 金澤素, 荻島創一, 栗山進一, 辻一郎, 寳澤篤, 福土審

日本公衆衛生学会総会抄録集　81回　201-201　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災による自宅の被害状況と高血圧治療中断との関連

畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中村智洋, 後岡広太郎, 小原拓, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　196-196　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
呼吸機能検査指標と高血圧有病との関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 土屋菜歩, 平田匠, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　202-202　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
被災後住居形態と肝機能指標に関する横断研究

相場繁, 中谷直樹, 小暮真奈, 中谷久美, 畑中里衣子, 千葉一平, 菅野郁美, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　237-237　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
生活習慣病の既往がない者における食事パターンと受診行動および医療費の関連

五十嵐有香, 小暮真奈, 鈴木寿則, 畑中里衣子, 中谷久美, 菅野郁美, 千葉一平, 中村智洋, 荻島創一, 中谷直樹, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　246-246　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
握力および脚伸展力で測定した各筋力と生理学的データの関連

野路慶明, 畑中里衣子, 中谷直樹, 小暮真奈, 中谷久美, 千葉一平, 菅野郁美, 中村智洋, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　431-431　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
呼吸機能検査指標と高血圧有病との関連

高瀬雅仁, 山田充啓, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 土屋菜歩, 平田匠, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　202-202　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Deep embedded clustering by relevant scales and genome-wide association study in autism

Fumihiko Ueno, Tomomi Onuma, Ippei Takahashi, Hisashi Ohseto, Akira Narita, Taku Obara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumiko Matsuzaki, Hirohito Metoki, Gen Tamiya, Shigeo Kure, Shinichi Kuriyama

2022/07/25

DOI： 10.1101/2022.07.25.500917 　
Validation of the Mother-to-Infant Bonding Scale for Infant Maltreatment by Mothers at One Month Postpartum: An Adjunct Study of the Japan Environment and Children's Study.

Toshie Nishigori, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Miyuki Mori, Taeko Suzuki, Mami Ishikuro, Nozomi Tatsuta, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi, Hidekazu Nishigori

JMA journal　5　(3)　366-369　2022/07/15

DOI： 10.31662/jmaj.2022-0041 　
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. International-journal

I Kanno, K Hasegawa, T Nakamura, M Kogure, F Itabashi, A Narita, N Tsuchiya, T Hirata, N Nakaya, J Sugawara, S Kuriyama, I Tsuji, S Kure, A Hozawa

Public health　208　98-104　2022/07

DOI： 10.1016/j.puhe.2022.05.003 　

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OBJECTIVES: Previous studies have reported the relationship between housing environment and health, although due to cost and effort, it was difficult to conduct housing condition surveys on a large scale. The CASBEE Housing Health Checklist (the Checklist) made it possible to easily evaluate the housing condition from the resident's perspective. This study examined the relationship between housing coldness/warmth evaluation using the Checklist and psychological distress in a large-scale general Japanese population. STUDY DESIGN: A cross-sectional study. METHODS: We analysed data from 29,380 people aged ≥20 years who lived in Miyagi Prefecture, Japan. As an assessment of housing coldness/warmth, we used the Checklist. We classified participants' total scores on the Checklist related to coldness/warmth into quartiles. The Kessler 6 scale was used as an indicator of psychological distress. Multivariable logistic regression models were used to estimate the adjusted odds ratio (OR) and 95% confidence intervals (CIs). Adjusted OR and P-values for linear trends were calculated using the quartiles of the Checklists' score. RESULTS: Among participants in Q1 (i.e., poorer subjective house condition), the percentage of people with psychological distress was high. Compared to the highest quartile, Q1 showed poorer evaluation of housing coldness/warmth, and higher OR for psychological distress. The OR (95% CI) of psychological distress for Q3, Q2, and Q1 compared with Q4 were 1.93 (1.74-2.14), 2.82 (2.55-3.12), and 5.78 (5.25-6.35), respectively. CONCLUSIONS: Housing coldness/warmth evaluation was significantly related to psychological distress. This finding suggests that maintaining a comfortable thermal environment at home could be important for residents' mental health.
Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. International-journal

Aoi Noda, Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Tatsui Otsuka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito, Junichi Sugawara, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

BMJ open　12　(6)　e060944　2022/06/07

DOI： 10.1136/bmjopen-2022-060944 　

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OBJECTIVES: This study aimed to examine the association between infertility treatment and neurodevelopment in children at 2 and 3.5 years of age. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: The study population consisted of mother-child pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire. OUTCOME MEASURES: The children's neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. We performed a multivariate logistic regression analysis of the association between infertility treatment (including ovulation induction (OI), artificial insemination with husband's sperm (AIH) and assisted reproductive technology (ART)) and the clinical range of ASQ-3. RESULTS: Of 9655 mother-child pairs, 273 (2.8%) and 487 (5.0%) were conceived through OI/AIH and ART, respectively. The odds of having developmental delays at 2 years of age were higher in children conceived through OI/AIH (OR, 1.36; 95% CI 1.00 to 1.85) and ART (OR, 1.36; 95% CI 1.07 to 1.72) than in those conceived naturally. Additionally, OI/AIH and ART were significantly associated with communication (OR, 1.93; 95% CI 1.25 to 2.98) and gross motor (OR, 1.50; 95% CI 1.08 to 2.09) delays, respectively. There were no statistically significant differences in the odds of having developmental delays at 3.5 years of age in children conceived through OI/AIH (OR, 1.13; 95% CI 0.79 to 1.61) and ART (OR, 1.03; 95% CI 0.78 to 1.37). CONCLUSION: In this study, we found a significant association between infertility treatment and children's neurodevelopment at 2 years of age, whereas no statistically significant differences were found at 3.5 years of age.
Review of Mental Health Consequences of the Great East Japan Earthquake through Long-Term Epidemiological Studies: The Shichigahama Health Promotion Project.

Yasuto Kunii, Hitomi Usukura, Yusuke Utsumi, Moe Seto, Yumiko Hamaie, Yumi Sugawara, Naoki Nakaya, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji, Hiroaki Tomita

The Tohoku journal of experimental medicine　257　(2)　85-95　2022/06/04

DOI： 10.1620/tjem.2022.J039 　

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After the Great East Japan Earthquake, Tohoku University began to provide mental health services during the acute phase of the disaster in cooperation with Shichigahama Town, one of the municipalities located in the coastal area of the Miyagi Prefecture that was severely damaged by the earthquake and tsunami; it continued to be providing long-term mental health activities, incorporating annual surveys for affected residents in the town for 10 years. Ten years of combination of surveys and outreach activities first depicted detailed longitudinal alterations in the mental health conditions of communities affected by a catastrophe. While posttraumatic stress reaction had recovered year by year after the year following the Great East Japan Earthquake, recovery from psychological distress retreated between 2014 and 2017, probably due to the relocation from temporal to eternal housing conditions. The annual cycles of assessment and provision of mental health support and promotion activities continued for 10 years can be an initial model for evidence-based, long-term post-disaster mental health and psychosocial support for the affected communities. Data regarding subsequent disasters should be collected in comparable ways, in order to improve the accuracy and usefulness of the accumulated data for planning and providing evidence-based post-disaster mental health and psychosocial support.
妊娠初期の消化管運動改善薬の大奇形リスク大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　24回　98-98　2022/06
Publisher: (一社)日本医薬品情報学会
2010-2019年の妊婦に対する降圧薬処方状況大規模レセプトデータベースを用いた評価

石川智史, 西郡秀和, 赤沢学, 都田桂子, 野田あおい, 石黒真美, 目時弘仁, 八重樫伸生, 栗山進一, 眞野成康, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　24回　99-99　2022/06
Publisher: (一社)日本医薬品情報学会
妊婦に対する抗精神病薬処方の実態レセプトデータベースに基づく検討

小原竜, 石川智史, 森下啓, 野田あおい, 松崎芙実子, 石黒真美, 栗山進一, 小原拓

日本医薬品情報学会総会・学術大会講演要旨集　24回　108-108　2022/06
Publisher: (一社)日本医薬品情報学会
Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.

Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ikumi Kanno, Kotaro Nochioka, Naho Tsuchiya, Takumi Hirata, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of atherosclerosis and thrombosis　30　(3)　255-273　2022/05/26

DOI： 10.5551/jat.63523 　

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AIM: Although many epidemiological studies have shown that obesity assessed by body mass index is associated with carotid intima-media thickness (cIMT), few studies have evaluated fat-free mass, which is a component of body composition. We investigated the associations between the combined fat mass index (FMI) and fat-free mass index (FFMI) with cIMT. METHODS: We conducted a cross-sectional study of 3,873 men and 9,112 women aged 20 years or older who lived in Miyagi prefecture, Japan. The FMI and FFMI were calculated as fat mass and fat-free mass divided by height squared, respectively. The indices were classified into sex-specific quartiles and were combined into 16 groups. The maximum common carotid artery was measured using high-resolution B-mode ultrasound. An analysis of covariance was used to assess associations between the combined FMI and FFMI with cIMT adjusted for age and smoking status. The linear trend test was conducted by stratifying the FMI and FFMI, scoring the categories from 1 (lowest) to 4 (highest), and entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher FMI was not related to higher cIMT in men and women in most FFMI subgroups. Conversely, a higher FFMI was related to higher cIMT in all FMI subgroups (p＜0.001 for linear trend). CONCLUSIONS: FMI was not associated with cIMT in most FFMI subgroups. Conversely, FFMI was positively associated with cIMT independently of FMI.
Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study. International-journal

Noriyuki Iwama, Taku Obara, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Tetsuro Hoshiai, Masatoshi Saito, Hirohito Metoki, Junichi Sugawara, Nobuo Yaegashi, Shinichi Kuriyama

Scientific reports　12　(1)　8921-8921　2022/05/26

DOI： 10.1038/s41598-022-12892-0 　

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This study aimed to construct a prediction model for small-for-gestational-age (SGA) infants in Japan by creating a risk score during pregnancy. A total of 17,073 subjects were included in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study, a prospective cohort study. A multiple logistic regression model was used to construct risk scores during early and mid-gestational periods (11-17 and 18-21 weeks of gestation, respectively). The risk score during early gestation comprised the maternal age, height, body mass index (BMI) during early gestation, parity, assisted reproductive technology (ART) with frozen-thawed embryo transfer (FET), smoking status, blood pressure (BP) during early gestation, and maternal birth weight. The risk score during mid-gestation also consisted of the maternal age, height, BMI during mid-gestation, weight gain, parity, ART with FET, smoking status, BP level during mid-gestation, maternal birth weight, and estimated fetal weight during mid-gestation. The C-statistics of the risk scores during early- and mid-gestation were 0.658 (95% confidence interval [CI]: 0.642-0.675) and 0.725 (95% CI: 0.710-0.740), respectively. In conclusion, the predictive ability of the risk scores during mid-gestation for SGA infants was acceptable and better than that of the risk score during early gestation.
Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of diabetes investigation　13　(5)　858-867　2022/05

DOI： 10.1111/jdi.13729 　

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AIMS/INTRODUCTION: Fat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between the fat mass index and fat-free mass index with HbA1c. MATERIALS AND METHODS: We carried out a cross-sectional study that included 3,731 men and 9,191 women aged ≥20 years, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An analysis of covariance was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounders. The linear trend test was carried out by stratifying the fat mass index and fat-free mass index, entering the number as a continuous term in the regression model. RESULTS: In multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P < 0.001 for linear trend). When we excluded the participants who had been identified as having diabetes, the fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P < 0.05 for linear trend). CONCLUSIONS: Fat mass index was positively related to HbA1c levels. The fat-free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Saya Kikuchi, Natsuko Kobayashi, Hirotaka Hamada, Noriyuki Iwama, Hirohito Metoki, Masatoshi Saito, Junichi Sugawara, Hiroaki Tomita, Nobuo Yaegashi, Shinichi Kuriyama

Scientific reports　12　(1)　6400-6400　2022/04/16

DOI： 10.1038/s41598-022-09944-w 　

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Personality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants.

Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, Yoichi Suzuki, Kichiya Suzuki, Akira Uruno, Mika Sakurai-Yageta, Yohei Hamanaka, Makiko Taira, Soichi Ogishima, Shinichi Kuriyama, Atsushi Hozawa, Hiroaki Tomita, Naoko Minegishi, Junichi Sugawara, Inaho Danjoh, Tomohiro Nakamura, Tomoko Kobayashi, Yumi Yamaguchi-Kabata, Shu Tadaka, Taku Obara, Eiji Hishimuma, Nariyasu Mano, Masaki Matsuura, Yuji Sato, Masateru Nakasone, Yohei Honkura, Jun Suzuki, Yukio Katori, Yoichi Kakuta, Atsushi Masamune, Yoko Aoki, Masaharu Nakayama, Shigeo Kure, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto

JMA journal　5　(2)　177-189　2022/04/15

DOI： 10.31662/jmaj.2021-0156 　

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Introduction: Pharmacogenomic (PGx) testing results provide valuable information on drug selection and appropriate dosing, maximization of efficacy, and minimization of adverse effects. Although the number of large-scale, next-generation-sequencing-based PGx studies has recently increased, little is known about the risks and benefits of returning PGx results to ostensibly healthy individuals in research settings. Methods: Single-nucleotide variants of three actionable PGx genes, namely, MT-RNR1, CYP2C19, and NUDT15, were returned to 161 participants in a population-based Tohoku Medical Megabank project. Informed consent was obtained from the participants after a seminar on the outline of this study. The results were sent by mail alongside sealed information letter intended for clinicians. As an exception, genetic counseling was performed for the MT-RNR1 m.1555A > G variant carriers by a medical geneticist, and consultation with an otolaryngologist was encouraged. Questionnaire surveys (QSs) were conducted five times to evaluate the participants' understanding of the topic, psychological impact, and attitude toward the study. Results: Whereas the majority of participants were unfamiliar with the term PGx, and none had undergone PGx testing before the study, more than 80% of the participants felt that they could acquire basic PGx knowledge sufficient to understand their genomic results and were satisfied with their potential benefit and use in future prescriptions. On the other hand, some felt that the PGx concepts or terminology was difficult to fully understand and suggested that in-person return of the results was desirable. Conclusions: These results collectively suggest possible benefits of returning preemptive PGx information to ostensibly healthy cohort participants in a research setting.
Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children's study. International-journal

Nozomi Tatsuta, Miyuki Iwai-Shimada, Shoji F Nakayama, Noriyuki Iwama, Hirohito Metoki, Takahiro Arima, Kasumi Sakurai, Akane Anai, Kaname Asato, Shinichi Kuriyama, Junichi Sugawara, Kichiya Suzuki, Nobuo Yaegashi, Michihiro Kamijima, Kunihiko Nakai

Environmental research　212　(Pt B)　113231-113231　2022/04/09

DOI： 10.1016/j.envres.2022.113231 　

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BACKGROUND: Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have been reported. This study aimed to examine the association between the maternal whole blood concentration of metallic elements (Hg, Pb, Cd, Mn, and Se) and GDM using the dataset of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study, which was designed to examine the adverse effects of pre/post-natal exposure to hazardous environment. METHODS: The data of 78,964 pregnant women who were participants of JECS were used. Blood samples were collected from the pregnant women at second/third trimester of gestation. We employed logistic regression analysis, quantile g-computation (QGC) and a distributed lag nonlinear model (DLNM) to examine the association between the blood concentration of metallic elements and the risk of GDM. RESULTS: The prevalence of GDM was 2.1%. In the logistic regression analyses, maternal blood Hg was associated with an increased risk of GDM. In QGC analysis, although metallic elements mixtures were not related to an increased risk of GDM, Hg (52.6%) may be the main contributor. According to the results of DLNM, for maternal exposure to Hg, 4.99 ng/g was identified as its susceptible minimum window for elevated risk of GDM. CONCLUSIONS: Our findings highlighted an association between Hg exposure and an increased risk of GDM. Studies of the underlying mechanisms and potential contributing factors, including fish intake, of this association are warranted.
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study. International-journal

Chikana Kawaguchi, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Shinichi Kuriyama, Taku Obara

BMC pregnancy and childbirth　22　(1)　242-242　2022/03/24

DOI： 10.1186/s12884-022-04556-8 　

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BACKGROUND: Maternal mental health problems in each of the prenatal period and postnatal period have been demonstrated as possible risk factors for atopic dermatitis (AD) in children. However, the cumulative impacts of maternal psychological distress in the prenatal and postnatal periods on AD in children remain unclear. This study examined the association between cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and the development of AD in children. METHODS: Data were derived from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. In total, 8377 mother-child pairs in which the child had no AD at the age of 1 year were analyzed. Maternal psychological distress in early pregnancy and 1 year after delivery was defined as a K6 score ≥ 5, and the participants were categorized into four groups: no psychological distress in both the prenatal and postnatal periods; only the prenatal period; only the postnatal period; and both periods. The development of AD was defined as the presence of AD in a 2-year-old child without AD reported at the age of 1 year using the International Study of Asthma and Allergies in Childhood questionnaire. Generalized linear model analyses were conducted to examine the association between maternal psychological distress and the development of AD in children adjusted for age at delivery, educational attainment, smoking status in pregnancy, maternal history of AD, paternal history of AD, parity, maternal body mass index, and child sex. RESULTS: Between the ages of 1 and 2 years, 14.0% of children developed AD. Maternal psychological distress in both prenatal and postnatal periods was associated with an increased risk of AD in children compared to no psychological distress in both periods (relative risk (RR), 95% confidence interval (CI): 1.34, 1.20-1.47). Maternal psychological distress in only the postnatal period was associated with an increased risk of AD in children (RR, 95% CI: 1.23, 1.07-1.39), but not in only the prenatal period (RR, 95% CI: 1.14, 0.98-1.30). CONCLUSIONS: Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods was associated with the development of AD in children.
Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. International-journal

Nobuo Fuse, Miyuki Sakurai, Ikuko N Motoike, Kaname Kojima, Takako Takai-Igarashi, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Mami Ishikuro, Taku Obara, Akiko Miyazawa, Kei Homma, Keisuke Ido, Makiko Taira, Tomoko Kobayashi, Ritsuko Shimizu, Akira Uruno, Eiichi N Kodama, Kichiya Suzuki, Yohei Hamanaka, Hiroaki Tomita, Junichi Sugawara, Yoichi Suzuki, Fuji Nagami, Soichi Ogishima, Fumiki Katsuoka, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Yaegashi, Shigeo Kure, Kengo Kinoshita, Masayuki Yamamoto

Ophthalmology science　2　(1)　100113-100113　2022/03
Publisher: Elsevier BV
DOI： 10.1016/j.xops.2022.100113 　

ISSN： 2666-9145

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Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data. Design: We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs). Participants: In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined. Methods: Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (discovery stage) and 11 104 participants in the BirThree Cohort (replication stage). We evaluated the associations of single nucleotide polymorphisms (SNPs) with AL using a genome-wide significance threshold (5 × 10-8) in each stage of the study and in the subsequent meta-analysis. Main Outcome Measures: We identified the association of SNPs with AL and distributions of AL in right and left eyes and individuals of different sexes and ages. Results: In the discovery stage, the mean AL of the right eye (23.99 mm) was significantly greater than that of the left eye (23.95 mm). This difference was reproducible across sexes and ages. The GWASs revealed 703 and 215 AL-associated SNPs with genome-wide significance in the discovery and validation stages, respectively, and many of the SNPs in the discovery stage were replicated in the validation stage. Validated SNPs and their associated loci were meta-analyzed for statistical significance (P < 5 × 10-8). This study identified 1478 SNPs spread over 31 loci. Of the 31 loci, 5 are known AL loci, 15 are known refractive-error loci, 4 are known corneal-curvature loci, and 7 loci are newly identified loci that are not known to be associated with AL. Of note, some of them shared functional relationships with previously identified loci. Conclusions: Our large-scale GWASs exploiting ToMMo Eye Study data identified 31 loci linked to variations in AL, 7 of which are newly reported in this article. The results revealed genetic heterogeneity and similarity in SNPs related to ethnic variations in AL.
東北メディカル・メガバンク計画健康調査における眼軸長のゲノムワイド関連解析

布施昇男, 櫻井美由紀, 元池育子, 小島要, 平良摩紀子, 宇留野晃, 濱中洋平, 中村智洋, 荻島創一, 寳澤篤, 栗山進一, 呉繁夫, 木下賢吾, 山本雅之

日本眼科学会雑誌　126　(臨増)　216-216　2022/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
Families' Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Mami Ishikuro, Aoii Noda, Keiko Murakami, Tomomi Onuma, Fumiko Matsuzaki, Fumihiko Ueno, Masahiro Kikuya, Hirohito Metoki, Hiroaki Tomita, Taku Obara, Nobuo Yaegashi, Shinichi Kuriyama

The Tohoku journal of experimental medicine　256　(2)　93-101　2022/02

DOI： 10.1620/tjem.256.93 　

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Infectious diseases, chronic diseases, and mental disorders in both adults and children are reported after disasters occur. The correlation between chronic diseases and mental disorders has also been reported. Moreover, disasters may affect perinatal outcomes. Thus, both adult and child health should be carefully monitored in disaster aftermath. A prospective cohort study of pregnant women and their families, the Tohoku Medical Megabank Project (TMM) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), has been conducted since 2013. A total of 73,529 family members participated in the TMM BirThree Cohort Study. Among siblings, the proportion of "small for gestational age" was the same in the pre- and post-disaster periods. Among parents and grandparents who answered the baseline questionnaire, 5.6% in the inland area and 19.8% in the coastal area had their houses totally/mostly destroyed by the Great East Japan Earthquake. Although a depression trend due to house damage was not observed in mothers, the proportion of psychological distress was high according to house damage (P for trend = 0.04). Among parents, there was an increase in overweight persons (P for trend = 0.004 in mothers and < 0.0001 in fathers) and in the number of smokers based on the severity of house damage (P for trend = 0.002 in mothers and < 0.0001 in fathers), whereas no such trend was observed in grandparents. Continuous monitoring and support for those who need are essential. Moreover, utilizing existing cohort studies to investigate health status when we face a new disaster is desirable.
乳児期の体重変化と幼児期過体重・肥満との関連東北メディカル・メガバンク計画三世代コホート調査

小林雅幸, 石黒真美, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 村上慶子, 小原拓, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　100-100　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Association between Recurrence or Exacerbation at Time of Disaster and Allergic Symptoms Several Years Later in Schoolchildren with Asthma or Atopic Dermatitis: The ToMMo Child Health Study

Masako Miyashita, Taku Obara, Mami Ishikuro, Masahiro Kikuya, Shinichi Kuriyama

The Tohoku Journal of Experimental Medicine　257　(1)　23-32　2022
Publisher: Tohoku University Medical Press
DOI： 10.1620/tjem.2022.j018 　

ISSN： 0040-8727

eISSN： 1349-3329
妊娠初期の消化管運動改善薬処方と児の大奇形との関連大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

Journal of Epidemiology　32　(Suppl.1)　141-141　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
日本人妊婦の食事パターンとSGAとの関連三世代コホート調査

山下貴宏, 小原拓, 米沢祐大, 高橋一平, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 岩間憲之, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　162-162　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 土屋菜歩, 平田匠, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　126-126　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Association of fish intake with menstrual pain: A cross-sectional study of the Japan Environment and Children's Study. International-journal

Emi Yokoyama, Takashi Takeda, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kasumi Sakurai, Naomi Shiga, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

PloS one　17　(7)　e0269042　2022

DOI： 10.1371/journal.pone.0269042 　

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The relationship between fish eating habits and menstrual pain is unknown. Elucidating this relationship can inform dietary guidance for reproductive age women with menstrual pain. The aim of this study was to clarify the relationship between fish intake frequency/preference and menstrual pain. This cross-sectional study was conducted at the Miyagi Regional Center as an adjunct study of the Japan Environment and Children's Study, and 2060 eligible women (mean age, 31.9 years) participated. Fish intake frequency ("< 1 time/week," "1 time/week," "2-3 times/week," or "≥ 4 times/week"), preference ("like," "neutral," or "dislike"), and menstrual pain (no/mild or moderate-to-severe) were assessed at 1.5 years after the last delivery through self-administered questionnaires. The association between fish intake frequency/preference and prevalence of moderate-to-severe menstrual pain was evaluated through logistic regression analyses. Our results show that, compared with the "< 1 time/week" (38.0%) group, the "1 time/week" (26.9%), "2-3 times/week" (27.8%), and "≥ 4 times/week" (23.9%) groups showed a lower prevalence of moderate-to-severe menstrual pain (p < 0.01). The prevalence of moderate-to-severe menstrual pain was 27.7%, 27.6%, and 34.4% in the "like," "neutral," and "dislike" groups, respectively. Multivariate logistic regression showed that frequent fish intake was associated with a lower prevalence of moderate-to-severe menstrual pain ("1 time/week": odds ratio [OR] = 0.59; 95% confidence interval [CI], 0.41-0.86, "2-3 times/week": OR = 0.64; 95% CI, 0.45-0.90 and "≥ 4 times/week": OR = 0.52; 95% CI, 0.34-0.80; trend p = 0.004). Multivariate logistic regression showed no association between fish preference and moderate-to-severe menstrual pain ("dislike" vs "like": OR = 1.16; 95% CI, 0.78-1.73). There was a significant negative association between fish intake frequency and menstrual pain. It is suggested that fish intake can reduce or prevent menstrual pain.
妊娠高血圧症候群と産後約3年の血圧値との関連東北メディカル・メガバンク計画三世代コホート調査

石黒真美, 長谷川茉柚, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　100-100　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
脂肪量指数および除脂肪量指数の組み合わせと頸動脈内膜中膜複合体厚(IMT)の肥厚との関連

高瀬雅仁, 中村智洋, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 菅野郁美, 土屋菜歩, 平田匠, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　32　(Suppl.1)　126-126　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
日本人妊婦の食事パターンとSGAとの関連三世代コホート調査

山下貴宏, 小原拓, 米沢祐大, 高橋一平, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 岩間憲之, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　132-132　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
母親の妊娠中と産後の心理的ストレス反応と児の問題行動との関連三世代コホート調査

高橋一平, 村上慶子, 五十嵐彩華, 小林美佳, 菊地紗耶, 大柳元, 野田あおい, 大沼ともみ, 松崎芙実子, 上野史彦, 石黒真美, 小原拓, 菅原準一, 富田博秋, 栗山進一

Journal of Epidemiology　32　(Suppl.1)　143-143　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
妊娠初期の消化管運動改善薬処方と児の大奇形との関連大規模レセプトデータベースを用いた評価

石川智史, 小原拓, 赤沢学, 野田あおい, 大柳元, 森下啓, 都田桂子, 西郡秀和, 川目裕, 八重樫伸生, 栗山進一, 眞野成康

Journal of Epidemiology　32　(Suppl.1)　141-141　2022/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study

Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Kotaro Nochioka, Akira Narita, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Taku Obara, Michihiro Satoh, Hirohito Metoki, Ken Miyagawa, Hiroshi Koshimizu, Sho Nagayoshi, Akira Uruno, Masahiro Kikuya, Kichiya Suzuki, Naoki Nakaya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension Research　2022

DOI： 10.1038/s41440-021-00843-7 　

ISSN： 0916-9636

eISSN： 1348-4214
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. International-journal

Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, Keita Iida, Kazuro Shimokawa, Takako Takai-Igarashi, Naoki Nakamura, Sachiko Nagase, Tomohiro Nakamura, Naho Tsuchiya, Naoki Nakaya, Keiko Murakami, Fumihiko Ueno, Tomomi Onuma, Mami Ishikuro, Taku Obara, Shunji Mugikura, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Akito Tsuboi, Shu Tadaka, Fumiki Katsuoka, Akira Narita, Mika Sakurai, Satoshi Makino, Gen Tamiya, Yuichi Aoki, Ritsuko Shimizu, Ikuko N Motoike, Seizo Koshiba, Naoko Minegishi, Kazuki Kumada, Takahiro Nobukuni, Kichiya Suzuki, Inaho Danjoh, Fuji Nagami, Kozo Tanno, Hideki Ohmomo, Koichi Asahi, Atsushi Shimizu, Atsushi Hozawa, Shinichi Kuriyama, Nobuo Fuse, Teiji Tominaga, Shigeo Kure, Nobuo Yaegashi, Kengo Kinoshita, Makoto Sasaki, Hiroshi Tanaka, Masayuki Yamamoto

Human genome variation　8　(1)　44-44　2021/12/10

DOI： 10.1038/s41439-021-00175-5 　

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To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
Prenatal folic acid supplementation and autism spectrum disorder in 3-year-old offspring: the Japan environment and children's study. International-journal

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Nozomi Tatsuta, Kasumi Sakurai, Masatoshi Saito, Junichi Sugawara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(25)　1-10　2021/12/02

DOI： 10.1080/14767058.2021.2007238 　

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OBJECTIVE: We evaluated the relationship between prenatal folic acid supplementation and autism spectrum disorder (ASD) in 3-year-old offspring. METHODS: We used data from the Japan Environment and Children's Study, a nationwide prospective birth cohort study. We analyzed the data to determine the association between folic acid supplement use and the incidence of ASD in offspring, and classified participants into three groups based on the time of initiation of folic acid supplementation, as follows: (1) preconception users of folic acid supplements and (2) post-conception users, and (3) non-users. The dietary folate intake of study participants was also classified into three groups (<200 µg, 200 µg to <400 µg, ≥400 µg). RESULTS: Overall, 361 offspring of 96,931 participants with single pregnancies were diagnosed with ASD (0.37%). A total of 7,046 participants (7.3%) used folic acid supplements before conception, 29,984 (30.9%) took them after detection of pregnancy, and 59,901 (61.8%) never received them. Multivariate logistic regression analyses demonstrated no association between prenatal folic acid supplementation and ASD in offspring (preconception use: adjusted odds ratio [AOR], 1.189; 95% confidence interval [CI], 0.819-1.727 and post-conception use: AOR, 1.072; 95% CI, 0.840-1.368); additionally, no association was observed with the use of folic acid supplements and/or multivitamin supplements (preconception use: AOR, 1.273; 95% CI, 0.921-1.760 and post-conception use: AOR, 1.132; 95% CI, 0.885-1.449). Moreover, no significant association was observed in participants with combined prenatal supplement use and dietary folate intake. CONCLUSIONS: Maternal use of folic acid supplements from the pre- or post-conception period was not significantly associated with ASD in 3-year-old offspring in Japan. Evaluation of the dietary folate intake from preconception also showed no significant association.
The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries. International-journal

Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, Fumi Itabashi, Naho Tsuchiya, Naoki Nakaya, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Shigeo Kure, Ichiro Tsuji, Atsushi Hozawa

Cancer medicine　10　(24)　9000-9011　2021/12

DOI： 10.1002/cam4.4364 　

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BACKGROUND: We determined the prevalence of current cigarette smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer in Japan and compared the findings with nationally representative studies in other countries. METHODS: We conducted a cross-sectional study of baseline data from a prospective cohort study. A self-administered questionnaire was surveyed during 2013-2015 with residents aged ≥20 years attending a community-based cardiometabolic screening program in Miyagi prefecture in north-eastern Japan. Subjects with past cancer histories were classified as cancer survivors. Sex-specific, age-standardized prevalence of current smokers, and drinkers were calculated. Age-adjusted prevalence ratios (PRs: the cancer survivors' rate divided by the rate of subjects with no history of cancer) and 95% confidence intervals (CIs) were estimated with log-binomial regressions. RESULTS: 36,786 subjects, including 2760 cancer survivors, responded and provided usable information (58.9% of recruited subjects). For men, the age-standardized prevalence of current smokers and drinkers among survivors was 18.8% and 74.4%, respectively, with an age-adjusted PR (95%CI) of 0.76 (0.66-0.86, p < 0.001) and 0.95 (0.91-0.98, p = 0.002), respectively. For women, the figures were 6.1%, 37.9%, 0.84 (0.67-1.06, p = 0.138) and 0.96 (0.90-1.03, p = 0.313), respectively. The U.S., the U.K, and Australian studies generally showed no substantially lower prevalence of current smokers or drinkers in survivors than in subjects with no history of cancer (PR ≥ 0.75), while Korean studies did (PR < 0.75). CONCLUSIONS: A considerable proportion of Japanese cancer survivors, especially men, remained currently smoking and drinking. Consistent with Western studies, the rates were not substantially lower than those among subjects with no history of cancer.
Living environments long-term after the Great East Japan Earthquake and nutritional intake among recent mothers. International-journal

Takahiro Yamashita, Keiko Murakami, Taku Obara, Yudai Yonezawa, Mami Ishikuro, Aoi Noda, Fumihiko Ueno, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

Asia Pacific journal of clinical nutrition　30　(4)　651-661　2021/12

DOI： 10.6133/apjcn.202112_30(4).0012 　

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BACKGROUND AND OBJECTIVES: Although large-scale natural disasters and the resultant changes in living environments worsen dietary habits among adults immediately after the disasters, whether this association remains for a long period is unclear. This is particularly important for recent mothers because lactating women require additional nutrition for milk production. Thus, we investigated the association of living environments with dietary habits and nutritional intake of recent mothers between four and seven years after the Great East Japan Earthquake (11th March, 2011). METHODS AND STUDY DESIGN: We analyzed 8,551 mothers who participated to the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Living environments were characterized into four categories: "same home before the earthquake", "rental housing", "reconstructed home", and "acquaintance's home". Dietary habits and nutritional intake were evaluated using a food frequency questionnaire answered 12 months after their deliveries (the questionnaire was answered between March 2015 and July 2018). RESULTS: Multiple linear regression analyses demonstrated that mothers in 'rental housing' or 'reconstructed home' had a significantly lower intake of almost all nutrients or certain nutrients, respectively, compared with those residing in 'same home before the earthquake'. However, fewer significant differences were detected between the nutritional intake of the mothers lodging in an 'acquaintance's home' and that of those living in 'same home before the earthquake'. CONCLUSIONS: Our findings indicate that living environments long-term after largescale disasters are associated with dietary habits and nutritional intake among recent mothers.
Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator

Mitsuhiro Yamada, Ikuko N. Motoike, Kaname Kojima, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Fumiki Katsuoka, Shu Tadaka, Matsuyuki Shirota, Miyuki Sakurai, Tomohiro Nakamura, Yohei Hamanaka, Kichiya Suzuki, Junichi Sugawara, Soichi Ogishima, Akira Uruno, Eiichi N. Kodama, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Mitsune, Takashi Ohe, Kengo Kinoshita, Masakazu Ichinose, Hisatoshi Sugiura, Masayuki Yamamoto

Communications Biology　4　(1)　2021/12
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s42003-021-02813-8 　

eISSN： 2399-3642

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<title>Abstract</title>Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be improved by adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese populations. Our GWAS with genotype imputations revealed that the <italic>RNF5/AGER</italic> locus including <italic>AGER</italic> rs2070600 SNP, which introduces a G82S substitution of AGER, was the most significantly associated with FEV₁/FVC. Three other rare missense variants of AGER were further identified. We also found genetic loci with three candidate genes (<italic>NOS2, SPSB2</italic> and <italic>RIPOR2</italic>) associated with FeNO levels. Analyses with the BioBank-Japan GWAS resource revealed genetic links of FeNO and asthma-related traits, and existence of common genetic background for allergic diseases and their biomarkers. Our study identified the genetic locus most strongly associated with airway obstruction in the Japanese population and three genetic loci associated with FeNO, an indicator of type 2 airway inflammation in adults.
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
パーソナリティと産後のメンタルヘルスとの関連三世代コホート調査

村上慶子, 目時弘仁, 栗山進一

日本公衆衛生学会総会抄録集　80回　381-381　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Risk of major congenital malformations associated with first-trimester exposure to propulsives: A health administrative database study in Japan. International-journal

Tomofumi Ishikawa, Taku Obara, Manabu Akazawa, Aoi Noda, Gen Oyanagi, Kei Morishita, Keiko Miyakoda, Hidekazu Nishigori, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　31　(2)　196-205　2021/10/10

DOI： 10.1002/pds.5370 　

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PURPOSE: To evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to propulsives with a special focus on domperidone using a large administrative database in Japan. METHODS: A large claims database was used from January 2005 to August 2016. The dates of pregnancy onset and delivery were estimated using the developed algorithms. Major congenital malformations were defined according to the International Classification of Diseases, 10th revision codes. We compared the infants' risk of overall MCMs between women with or without first-trimester prescriptions of propulsives and estimated the odds ratios (ORs) with unadjusted and adjusted analyses. We also compared the risk of overall MCMs between women with domperidone prescriptions and those with other propulsive prescriptions during the first trimester. RESULTS: Among 38 270 women, propulsives were prescribed to 3197 women (8.4%) in the first trimester, including domperidone to 371 women (1.0%). Propulsive prescriptions in the first trimester were not significantly associated with an increased risk of overall MCMs (adjusted OR [aOR] 1.030, 95% confidence interval [CI] 0.843-1.257). Compared to the prescription of other propulsives in the first trimester, the prescription of domperidone in the first trimester was not associated with an increased risk of overall MCMs (aOR 0.724, 95% CI 0.363-1.447). CONCLUSIONS: The first-trimester prescription of propulsives, including domperidone, was not associated with an increased risk of overall MCMs. This article is protected by copyright. All rights reserved.
Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. International-journal

Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, Akira Narita, Tomohiro Nakamura, Hirohito Metoki, Taku Obara, Mami Ishikuro, Atsushi Hozawa, Harold Snieder, Shinichi Kuriyama

Atherosclerosis　334　85-92　2021/10

DOI： 10.1016/j.atherosclerosis.2021.08.037 　

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BACKGROUND AND AIMS: Few studies have examined and compared spousal concordance in different populations. This study aimed to quantify and compare spousal similarities in cardiometabolic risk factors and diseases between Dutch and Japanese populations. METHODS: This cross-sectional study included 28,265 Dutch Lifelines Cohort Study spouse pairs (2006-2013) and 5,391 Japanese Tohoku Medical Megabank Organization (ToMMo) Cohort Study pairs (2013-2016). Spousal similarities in cardiometabolic risk factors were evaluated using Pearson's correlation or logistic regression analyses adjusted for spousal age. RESULTS: The husbands' and wives' average ages in the Lifelines and ToMMo cohorts were 50.0 and 47.7 years and 63.2 and 60.4 years, respectively. Significant spousal similarities occurred with all cardiometabolic risk factors and diseases of interest in both cohorts. The age-adjusted correlation coefficients ranged from 0.032 to 0.263, with the strongest correlations observed in anthropometric traits. Spousal odds ratios [95% confidence interval] for the Lifelines vs. ToMMo cohort ranged from 1.45 (1.36-1.55) vs. 1.20 (1.05-1.38) for hypertension to 6.86 (6.30-7.48) vs. 4.60 (3.52-6.02) for current smoking. An increasing trend in spousal concordance with age was observed for sufficient physical activity in both cohorts. For current smoking, those aged 20-39 years showed the strongest concordance between pairs in both cohorts. The Dutch pairs showed stronger similarities in anthropometric traits and lifestyle habits (smoking and drinking) than their Japanese counterparts. CONCLUSIONS: Spouses showed similarities in several cardiometabolic risk factors among Dutch and Japanese populations, with regional and cultural influences on spousal similarities.
Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Noriyuki Iwama, Masahiro Kikuya, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama

2021/09/15
Publisher: Research Square Platform LLC
DOI： 10.21203/rs.3.rs-887730/v1 　

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<title>Abstract</title> ObjectiveThe aim of our study was to develop prediction model for preeclampsia (PE) using routinely examined items in early pregnancy especially dipstick test for proteinuria.MethodThe Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women and we included 9,086 of them in analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test of proteinuria were obtained by medical record at regular antenatal care. The outcome was defined as PE including superimposed preeclampsia. We developed prediction model without dipstick test of proteinuria (model 1) and model with it (model 2), and we compared them by the mean of area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation.ResultsmAUROC of model 1 was 0.769 (95% CI; 0.741 to 0.797) and that of model 2 was 0.785 (95% CI; 0.758 to 0.812). The difference of two mAUROCs was 0.016 (95% CI; 0.004 to 0.028). In model 2, detection rates at false-positive rate of 5%, 10% and 20% were 40%, 49% and 64%, respectively.ConclusionsWe could develop prediction model for PE using routine antenatal care items and it was improved by including dipstick test for proteinuria.
Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. International-journal

Takafumi Yamauchi, Daisuke Ochi, Naomi Matsukawa, Daisuke Saigusa, Mami Ishikuro, Taku Obara, Yoshiki Tsunemoto, Satsuki Kumatani, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Seizo Koshiba, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Masao Nagasaki, Satoshi Hiyama, Junichi Sugawara

Scientific reports　11　(1)　17777-17777　2021/09/07

DOI： 10.1038/s41598-021-97342-z 　

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The elucidation of dynamic metabolomic changes during gestation is particularly important for the development of methods to evaluate pregnancy status or achieve earlier detection of pregnancy-related complications. Some studies have constructed models to evaluate pregnancy status and predict gestational age using omics data from blood biospecimens; however, less invasive methods are desired. Here we propose a model to predict gestational age, using urinary metabolite information. In our prospective cohort study, we collected 2741 urine samples from 187 healthy pregnant women, 23 patients with hypertensive disorders of pregnancy, and 14 patients with spontaneous preterm birth. Using gas chromatography-tandem mass spectrometry, we identified 184 urinary metabolites that showed dynamic systematic changes in healthy pregnant women according to gestational age. A model to predict gestational age during normal pregnancy progression was constructed; the correlation coefficient between actual and predicted weeks of gestation was 0.86. The predicted gestational ages of cases with hypertensive disorders of pregnancy exhibited significant progression, compared with actual gestational ages. This is the first study to predict gestational age in normal and complicated pregnancies by using urinary metabolite information. Minimally invasive urinary metabolomics might facilitate changes in the prediction of gestational age in various clinical settings.
One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Natsuko Kobayashi, Junichi Sugawara, Masayuki Yamamoto, Nobuo Yaegashi, Shinichi Kuriyama, Hiroaki Tomita

Journal of affective disorders　295　632-638　2021/09/04

DOI： 10.1016/j.jad.2021.08.118 　

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BACKGROUND: Trajectories of postpartum depressive symptoms up to 1 year after childbirth and the related risk factors remain unclear. Accordingly, this study aimed to examine the 1-year trajectories of postpartum depressive symptoms and their associated risk factors. METHODS: A total of 22,493 pregnant women were recruited between July 2013 and September 2016 in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Among them, 11,668 women with no missing data were included in the analyses. Depressive symptoms were assessed at 1 month and 1 year postpartum using the Edinburgh Postnatal Depression Scale. Multinominal logistic regression analysis was conducted after adjusting for covariates. RESULTS: The prevalence of depression was 13.9% at 1 month and 12.9% at 1 year postpartum. We identified four depression trajectories, i.e., "persistent (depressed throughout the 1 year postpartum)" (6.0%), "recovered (depressed at 1 month postpartum and recovered within a year)" (7.9%), "late-onset (became depressed after 1 month postpartum)" (6.8%), and "resilient (not depressed throughout 1 year postpartum)" (79.2%). Psychological distress during pregnancy was significantly associated with all trajectories (persistent: odds ratio [OR]=10.24, 95% confidence interval (CI)=8.40-12.48; recovered: OR=3.78, 95%CI=3.28-4.36; and late-onset: OR=3.96, 95%CI=3.40-4.62). LIMITATIONS: Postpartum depression was evaluated only by a self-administered questionnaire and the dropout rate was not neglectable. CONCLUSIONS: This study highlighted the high prevalence of depressive symptoms at 1 year postpartum and found that half of the depressive symptoms at 1 year were late-onset. The findings suggest the necessity of long-term follow-up (up to 1 year) for perinatal mental health.
東北メディカル・メガバンク計画三世代コホート調査の進捗報告

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 菅原準一, 栗山進一

DOHaD研究　9　(1)　28-28　2021/09
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
出生コホート連携に基づく胎児期から乳幼児期の環境と母児の予後との関連に関する研究

小原拓, 岸玲子, 佐田文宏, 清水厚志, 菅原準一, 土屋賢治, 堀川玲子, 目時弘仁, 森崎菜穂, 森千里, 栗山進一

DOHaD研究　9　(1)　77-77　2021/09
Publisher: (一社)日本DOHaD学会
ISSN： 2187-2562

eISSN： 2187-2597
662Factors associated with smoking continuation and indoor smoking among pregnant women’s partners

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

International Journal of Epidemiology　50　(Supplement_1)　2021/09/01
Publisher: Oxford University Press (OUP)
DOI： 10.1093/ije/dyab168.464 　

ISSN： 0300-5771

eISSN： 1464-3685

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<title>Abstract</title> <sec> <title>Background</title> Secondhand smoke by partners is a major source of exposure for non-smoking women. However, factors associated with smoking continuation and indoor smoking among pregnant women’s partners remain unknown. </sec> <sec> <title>Methods</title> We used data from 6348 partners of non-smoking pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan from 2013 to 2017. Partners’ age, educational attainment, equivalent household income, and pregnant women’s smoking history (never, quitting before pregnancy awareness, quitting after pregnancy awareness) were used as explanatory variables. Multivariate logistic regression analyses were conducted to examine the associations between these variables and smoking continuation/indoor smoking of partners. </sec> <sec> <title>Results</title> Among 6348 partners, 2506 partners had been smokers at pregnancy awareness. Among them, the prevalence of smoking continuation after pregnancy awareness was 92.0%. Partners whose wives had quitted smoking after pregnancy awareness were less likely to continue smoking than partners whose wives had never smoked; the odds ratio was 0.57 (95% confidence interval, 0.41–0.80). Among partners who continued smoking, the prevalence of indoor smoking was 30.7%. Partners with ≤high school education were more likely to smoke indoors than partners with ≥university education; the odds ratio was 1.60 (95% confidence interval, 1.23–2.07). </sec> <sec> <title>Conclusions</title> Women’s smoking cessation after pregnancy awareness was associated with decreased risk of partners’ smoking continuation, and lower level of partners’ education was associated with increased risk of partners’ indoor smoking. </sec> <sec> <title>Key messages</title> Interventions for both women and their partners may be effective in reducing secondhand smoke exposure during pregnancy. </sec>
Associations of education and work status with alcohol use and cessation among pregnant women in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

BMC public health　21　(1)　1400-1400　2021/07/15

DOI： 10.1186/s12889-021-11461-w 　

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BACKGROUND: There is inconsistent evidence on the associations of education and work status with alcohol use during pregnancy. Our aim was to examine the associations of education and work status with alcohol use and alcohol cessation during pregnancy in Japan. METHODS: Data were analyzed from 11,839 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017 in Japan. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Alcohol cessation was defined as alcohol use in early pregnancy, but not in middle pregnancy. Multivariable log-binomial regression analyses were conducted to examine associations of education and work status with alcohol use in early and middle pregnancy and alcohol cessation, adjusted for age and income. The prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated by work status and education. RESULTS: The prevalence of alcohol use in early and middle pregnancy was 20.9 and 6.4%, respectively. Higher education was associated with alcohol use in early pregnancy both among working and non-working women; the PRs of university education or higher compared with high school education or lower were 1.62 (95% CI, 1.34-1.96) and 1.29 (95% CI, 1.16-1.45), respectively. Higher education was associated with alcohol cessation during pregnancy among working women; the corresponding PR was 1.09 (95% CI, 1.01-1.17). Working was associated with alcohol use in early and middle pregnancy. Working was associated with a decreased probability of alcohol cessation among women with lower education but with an increased probability of alcohol cessation among women with higher education; the PRs of working compared with not working were 0.91 (95% CI, 0.82-1.00) and 1.10 (95% CI, 1.00-1.20), respectively. CONCLUSIONS: Women with higher education were more likely to consume alcohol in early pregnancy and to cease alcohol use between early and middle pregnancy, especially working women. Working women were more likely to consume alcohol throughout pregnancy. Working women with lower education were less likely to cease alcohol use, whereas working women with higher education were more likely to cease alcohol use between early and middle pregnancy.
The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. International-journal

Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Jun Yasuda, Yumi Yamaguchi-Kabata, Kengo Kinoshita, Soichi Ogishima, Takako Takai, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Tomohiro Nakamura, Naoko Minegishi, Junichi Sugawara, Kichiya Suzuki, Hiroaki Tomita, Akira Uruno, Tomoko Kobayashi, Yayoi Aizawa, Tomoharu Tokutomi, Kayono Yamamoto, Kinuko Ohneda, Shigeo Kure, Yoko Aoki, Hideki Katagiri, Yasushi Ishigaki, Shojiro Sawada, Makoto Sasaki, Masayuki Yamamoto

Journal of human genetics　67　(1)　9-17　2021/07/08

DOI： 10.1038/s10038-021-00952-8 　

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Certain large genome cohort studies attempt to return the individual genomic results to the participants; however, the implementation process and psychosocial impacts remain largely unknown. The Tohoku Medical Megabank Project has conducted large genome cohort studies of general residents. To implement the disclosure of individual genomic results, we extracted the potential challenges and obstacles. Major challenges include the determination of genes/disorders based on the current medical system in Japan, the storage of results, prevention of misunderstanding, and collaboration of medical professionals. To overcome these challenges, we plan to conduct multilayer pilot studies, which deal with different disorders/genes. We finally chose familial hypercholesterolemia (FH) as a target disease for the first pilot study. Of the 665 eligible candidates, 33.5% were interested in the pilot study and provided consent after an educational "genetics workshop" on the basic genetics and medical facts of FH. The genetics professionals disclosed the results to the participants. All positive participants were referred to medical care, and a serial questionnaire revealed no significant psychosocial distress after the disclosure. Return of genomic results to research participants was implemented using a well-prepared protocol. To further elucidate the impact of different disorders, we will perform multilayer pilot studies with different disorders, including actionable pharmacogenomics and hereditary tumor syndromes.
Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. International-journal

Masato Takase, Tomohiro Nakamura, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Akira Narita, Takumi Hirata, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki, Nobuo Fuse, Akira Uruno, Eiichi N Kodama, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Clinical and experimental hypertension (New York, N.Y. : 1993)　43　(7)　1-12　2021/07/06

DOI： 10.1080/10641963.2021.1925681 　

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BACKGROUND: A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. METHODS: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. RESULTS: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. CONCLUSIONS: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.
Associations of education and income with hazardous drinking among postpartum women in Japan: results from the TMM BirThree Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Environmental health and preventive medicine　26　(1)　70-70　2021/07/03

DOI： 10.1186/s12199-021-00991-9 　

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BACKGROUND: Although the postpartum period is suggested to provide an ideal opportunity for interventions to prevent hazardous drinking, evidence on the associations of education and income with hazardous drinking during this period is limited, including in Japan. METHODS: We analyzed data from 11,031 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Japan. Hazardous drinking was defined as ethanol intake of ≥20 g/day 1 year after delivery. We conducted multiple logistic regression analyses to examine whether educational attainment or equivalent household income was associated with hazardous drinking, adjusting for age, parity, drinking status during pregnancy, work status, postpartum depression, breastfeeding, and income/education. We also conducted stratified analyses by income and education groups. RESULTS: The prevalence of hazardous drinking 1 year after delivery was 3.6%. Lower education was associated with hazardous drinking; the odds ratio (95% confidence interval) of high school education or lower compared with university education or higher was 2.17 (1.59-2.98). Lower income was also associated with hazardous drinking, but this association disappeared after further adjustments for education; the odds ratios (95% confidence intervals) of the lowest compared with highest level of income were 1.42 (1.04-1.94) and 1.12 (0.81-1.54), respectively. A significant interaction was detected; lower education and lower income were associated with increased risks of hazardous drinking only in a lower income group and lower education group, respectively. CONCLUSIONS: Postpartum women with lower education and lower income had higher risks of hazardous drinking in Japan.
Relation between disaster exposure, maternal characteristics, and obstetric outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Masahiro Kikuya, Junichi Sugawara, Hirohito Metoki, Shinichi Kuriyama

Journal of epidemiology　33　(3)　127-135　2021/07/03

DOI： 10.2188/jea.JE20210052 　

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BACKGROUND: The study analyzed the relation between disaster exposure prior to pregnancy, maternal characteristics, and obstetric outcomes. METHODS: The participants were 13,148 pregnant women recruited from 2013 to 2017. The women were classified into three groups by the severity of housing damage caused by the Great East Japan Earthquake of 2011: group A, house was not destroyed/did not live in the disaster area; group B, half/part of the house was destroyed; and group C, house was totally/mostly destroyed. Maternal characteristics, hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and gestational weeks were obtained by questionnaires and medical records. Multiple logistic regression analyses were performed to investigate the relation between disaster exposure and maternal characteristics, HDP, and GDM. A structural equation model was applied to investigate the relation between disaster exposure, and HDP and gestational weeks. RESULTS: The homes of about 11% of the women were totally/mostly destroyed. For groups B and C compared with those in group A, the adjusted ORs for HDP were 1.04 and 1.26 (P for trend = 0.01), and for GDM were 0.89 and 1.14 (P for trend = 0.9), respectively. Pre-pregnancy body mass index (BMI) mediated 23.2% of the relation between disaster exposure and HDP. Disaster exposure was associated with gestational weeks. CONCLUSION: Disaster exposure at least 2.5 years before pregnancy was found to be associated with maternal characteristics and the prevalence of HDP. Pre-pregnancy BMI mediated the relation between disaster exposure and the prevalence of HDP, and gestational weeks were reduced through HDP.
Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. International-journal

Takumi Hirata, Mana Kogure, Naho Tsuchiya, Ken Miyagawa, Akira Narita, Kotaro Nochioka, Akira Uruno, Taku Obara, Tomohiro Nakamura, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　44　(7)　858-865　2021/07

DOI： 10.1038/s41440-021-00628-y 　

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Recently, a high urinary sodium-to-potassium (Na/K) ratio and reduced sleep efficiency, in addition to conventional risk factors (obesity and excess alcohol intake), have been identified as risk factors for hypertension. We estimated the population attributable fraction (PAF) for home hypertension due to these risk factors in a general Japanese population. We conducted a cross-sectional study including 1384 participants (393 men and 991 women) to estimate the odds ratio (OR) and 95% confidence interval (CI) for the presence of any of the conventional risk factors using multivariable logistic regression analyses. The models were adjusted for sex, age, smoking status, and log-transformed average daily steps. We also estimated the OR and 95% CI for the presence of any of the overall risk factors. Furthermore, we calculated the PAF due to these risk factors. The results showed that the prevalence of home hypertension was 39.0% (540/1384). The presence of any of the conventional risk factors, as well as any of the overall risk factors, was significantly associated with an increased prevalence of hypertension (OR 2.80, 95% CI 2.15-3.65; OR 2.50, 95% CI 1.93-3.22, respectively). The PAF for hypertension due to the presence of any of the conventional risk factors and the PAF due to the presence of any of the overall risk factors were 30.2% and 39.0%, respectively. In conclusion, the impact of the overall risk factors, including the urinary Na/K ratio and sleep efficiency, on home hypertension was higher than that of conventional risk factors alone. The management of the urinary Na/K ratio and sleep efficiency as well as conventional risk factors might be important in the management of blood pressure.
Maternal personality and alcohol use during pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Hirohito Metoki, Taku Obara, Shinichi Kuriyama

Addictive behaviors　122　107020-107020　2021/06/16

DOI： 10.1016/j.addbeh.2021.107020 　

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BACKGROUND: Studies on associations between maternal personality and alcohol use have examined only one time point during pregnancy in Western countries. We aimed to examine the association between maternal personality and alcohol use in early and middle pregnancy in Japan. METHODS: We analyzed data from 17,144 pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. Personality was assessed using the short-form Eysenck Personality Questionnaire-Revised. Women were dichotomized as current drinkers or non-drinkers in both early and middle pregnancy. Odds ratios (ORs) and 95% confidence intervals (CIs) for alcohol use in early and middle pregnancy and continued alcohol use between early and middle pregnancy were calculated for 1 standard deviation increase in each personality scale, adjusted for age, as well as education, work status, fertility treatment, and parity. RESULTS: Higher extraversion scores were associated with alcohol use in early (OR, 1.16; 95% CI, 1.12-1.20) and middle pregnancy (OR, 1.17; 95% CI, 1.10-1.25). Higher psychoticism scores were associated with continued alcohol use into middle pregnancy (OR, 1.07; 95% CI, 1.01-1.14) and alcohol use in middle pregnancy (OR, 1.07; 95% CI, 1.02-1.13). Neuroticism was not associated with alcohol use in early or middle pregnancy. Lower lie was associated with alcohol use in early (OR, 0.95; 95% CI, 0.91-0.98), but not in middle pregnancy. CONCLUSIONS: Different personality scales are associated with alcohol use at different points during pregnancy.
Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

European journal of clinical nutrition　76　(2)　261-269　2021/06/15

DOI： 10.1038/s41430-021-00939-w 　

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BACKGROUND/OBJECTIVES: Studies have reported the effects of grain consumption on human health, but the association between maternal grain consumption before and during pregnancy and birth weight remains unclear. We evaluated the association between maternal grain consumption before and during pregnancy and birth weight/low birth weight (LBW). SUBJECTS/METHODS: Grain consumption was calculated using two semi-quantitative food frequency questionnaires (FFQs). The two FFQs evaluated consumption from pre- to early pregnancy and then from early to mid-pregnancy, respectively. Information concerning birth weight was obtained from birth records, and multivariable analyses for birth weight and LBW risk were conducted after adjusting for potential confounders. RESULTS: In total, 17,610 pregnant women (age, 31.8 ± 4.9 years; smoked during pregnancy, 16.1%; gestation period, 38.5 ± 2.5 weeks; first childbirth, 45.5%) and their singleton and term new-borns (birth weight, 3061.8 ± 354.1 g; LBW, 5.4%) were included in the analysis. Women in the highest quartile of grain consumption from pre- to early pregnancy had heavier new-borns (β = 22.3; 95% confidence interval (CI): 5.8-38.9) but did not have a significantly lower LBW risk (odds ratio [OR]: 0.87; 95% CI: 0.71-1.07) than women in the lowest quartile. Women in the highest quartile of grain consumption from early to mid-pregnancy also had heavier new-borns (β = 24.1; 95% CI: 7.1-41.1) but did not have a significantly lower LBW risk (OR: 0.85; 95% CI: 0.69-1.05) than women in the lowest quartile. CONCLUSIONS: Grain consumption before and during pregnancy was positively associated with birth weight.
Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan. International-journal

Yudai Yonezawa, Fumihiko Ueno, Taku Obara, Takahiro Yamashita, Mami Ishikuro, Keiko Murakami, Aoi Noda, Tomomi Onuma, Junichi Sugawara, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

The British journal of nutrition　127　(8)　1-9　2021/06/14

DOI： 10.1017/S0007114521002154 　

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The association between fruit and vegetable consumption before and during pregnancy and offspring's physical growth has been well reported, but no study has focused on offspring's neurological development. We aimed to explore the association between maternal fruit and vegetable consumption before and during pregnancy and developmental delays in their offspring aged 2 years. Between July 2013 and March 2017, 23 406 women were recruited for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Fruit and vegetable consumption was calculated using FFQ, and offspring's developmental delays were evaluated by the Ages & Stages Questionnaires, Third Edition (ASQ-3) for infants aged 2 years. Finally, 10 420 women and 10 543 infants were included in the analysis. Totally, 14·9 % of children had developmental delay when screened using the ASQ-3. Women in the highest quartile of vegetable consumption from pre-pregnancy to early pregnancy and from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·74; 95 % CI 0·63, 0·89 and OR 0·70; 95 % CI 0·59, 0·84, respectively) than women in the lowest quartile. Women in the highest quartile of fruit consumption from early to mid-pregnancy had lower odds of offspring's developmental delays (OR 0·78; 95 % CI 0·66, 0·92) than women in the lowest quartile. In conclusion, high fruit and vegetable consumption before and during pregnancy was associated with a lower risk of developmental delays in offspring aged 2 years.
Changes in height standard deviation scores during early life are affected by nutrition. International-journal

Toshiaki Tanaka, Noriko Kato, Susumu Yokoya, Atsushi Ono, Tsuyoshi Isojima, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Shoichi Chida, Mitsuaki Hosoya, Shinichi Kuriyama, Shigeo Kure

Pediatrics international : official journal of the Japan Pediatric Society　63　(6)　710-715　2021/06

DOI： 10.1111/ped.14577 　

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BACKGROUND: Large changes in height standard deviation score (SDS) have been reported from birth to 3 years of age. We analyzed how early these changes start and whether they are affected by nutrition. METHODS: The longitudinal growth of 1,849 children born between March 1 2007 and August 31 2007 or between March 1, 2009 and August 31 2009 with five records from birth to 3 years of age was analyzed. RESULTS: The height SDS at birth was positively correlated with body mass index (BMI) SDS at birth (r = 0.224, P < 0.0001). The height SDS at birth decreased among children with a positive height SDS and increased among children with a negative height SDS. The changes occurred immediately after birth and became more modest as children aged. Regarding the change in the height SDS from birth to 3 years of age, 33.4% of children increased more than 0.5 SDs, 39.8% of children decreased more than 0.5 SDs, and 34.4% of children remained within ±0.5 SDs. The change in height SDS displayed a strong positive correlation with the change in weight during the four periods. From birth till 3 months, from 3 months till 6 months, from 6 months till 1.5 years, and from 1.5 years till 3 years. CONCLUSIONS: The significant positive correlation between height SDS and BMI SDS suggests an effect of children's nutrition status in utero. The height SDS change started immediately after birth and the change was largest from birth to 3 months. A positive correlation between changes in height SDS and weight suggest that growth during early childhood depends on nutritional status.
Hypertension in pregnancy as a possible factor for child autistic behavior at two years old. International-journal

Mami Ishikuro, Keiko Murakami, Fumiya Yokozeki, Tomomi Onuma, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

Pregnancy hypertension　25　88-90　2021/05/28

DOI： 10.1016/j.preghy.2021.05.020 　

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We investigated the association between hypertensive disorders of pregnancy (HDP) subtypes and child autistic behavior to accumulate the evidence. We found the association between superimposed preeclampsia and autistic behavior in children aged two years old by investigating 6794 mother-child pairs in the birth cohort study. Since early intervention for autism-spectrum disorder might be effective, it suggests that early prediction is necessary for children born of mothers who developed particularly superimposed preeclampsia to support their development. Not only for introducing early prediction, but also research for establishing effective intervention is necessary.
Factors associated with postpartum smoking relapse among women who quit in early pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of epidemiology　33　(1)　8-14　2021/04/28

DOI： 10.2188/jea.JE20200609 　

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BACKGROUND: While a wide range of predictors of postpartum smoking relapse have been suggested, population-based studies have rarely examined these factors exclusively among women who quit in early pregnancy. Furthermore, workplace secondhand smoke (SHS) exposure has never been examined. METHODS: We analyzed data from 10,466 pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Age, education, parity, breastfeeding, postpartum depression, SHS exposure at home, and SHS exposure at work (not working, working without SHS exposure, working with SHS exposure) were evaluated as possible predictors. Multiple logistic regression analyses were conducted to examine the associations between these factors and smoking relapse by 1 year postpartum among women who quit in early pregnancy. Analyses stratified by SHS exposure at home were also conducted. RESULTS: About one-fourth of early-pregnancy quitters had relapsed into smoking by 1 year postpartum. Lower education, multiparity, not breastfeeding, postpartum depression, and SHS exposure at home were associated with increased risks of smoking relapse. Working with SHS exposure was associated with an increased risk of smoking relapse; the multivariate-adjusted odds ratios (95% confidence intervals) of working without SHS exposure and working with SHS exposure compared with not working were 1.14 (0.82-1.59) and 2.18 (1.37-3.46), respectively. The significant association of workplace SHS exposure was observed only among women without SHS exposure at home. CONCLUSIONS: SHS exposure at work, as well as education, multiparity, breastfeeding, postpartum depression, and SHS exposure at home were associated with postpartum smoking relapse among early-pregnancy quitters.
Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan

Kengo Kato, Ryoukichi Ikeda, Jun Suzuki, Ai Hirano-Kawamoto, Yayoi Kamakura, Masako Fujiu-Kurachi, Masamitsu Hyodo, Shin-Ichi Izumi, Shigeto Koyama, Keiichi Sasaki, Junko Nakajima, Takahiro Karaho, Yurika Kimura, Yoshihiko Kumai, Yasushi Fujimoto, Takaharu Nito, Yoshitaka Oku, Hajime Kurosawa, Shinichi Kuriyama, Yukio Katori

Auris Nasus Larynx　48　(2)　241-247　2021/04
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2020.08.004 　

ISSN： 0385-8146
Maternal personality and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. International-journal

Keiko Murakami, Fumihiko Ueno, Ibuki Nakamura, Mami Ishikuro, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of affective disorders　282　580-586　2021/03/01

DOI： 10.1016/j.jad.2020.12.187 　

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BACKGROUND: Despite much knowledge of the effects of maternal psychopathology on bonding, the effects of personality have received less attention. We aimed to examine the association between maternal personality and postnatal bonding disorder. METHODS: We analyzed data from 15,654 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised, with the score for each subscale categorized into four levels. Bonding disorder was defined as the Mother-to-Infant Bonding Scale score of ≥5 one month after delivery. Multiple logistic regression analyses were conducted to examine the association between personality and bonding disorder after adjusting for age, education, parity, feelings towards pregnancy, social isolation, as well as the Edinburgh Postpartum Depression Scale (EPDS) score. RESULTS: Higher extraversion was associated with a decreased risk of bonding disorder (p for trend <0.001). Higher neuroticism was associated with an increased risk of bonding disorder (p for trend <0.001), and this association disappeared after further adjustment for EPDS score (p for trend 0.39). No association between psychoticism and bonding disorder was observed (p for trend 0.83), and the association appeared after further adjustment for EPDS score (p for trend 0.0017). Higher lie was associated with a decreased risk of bonding disorder (p for trend <0.001). LIMITATIONS: Maternal personality and bonding were self-reported. CONCLUSIONS: Lower extraversion, higher psychoticism, and lower lie were associated with bonding disorder. The association between higher neuroticism and bonding disorder was explained by postnatal depressive symptoms.
The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. International-journal

Kaou Tanoue, Zen Watanabe, Hidekazu Nishigori, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kousuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Environmental health and preventive medicine　26　(1)　27-27　2021/02/26

DOI： 10.1186/s12199-021-00944-2 　

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BACKGROUND: To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan. METHODS: This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined 76,152 pregnant women including 8270 in Miyagi Regional Center and 67,882 in 13 other regional centers from the all-birth fixed data of the Japan Environment and Children's Study. We then compared the prevalence and risk of distress in women in Miyagi Regional Center and women in the 13 regional centers for 3 years after the disaster. RESULTS: Women in the Miyagi Regional Center suffered more psychological distress than those in the 13 regional centers: OR 1.38 (95% CI, 1.03-1.87) to 1.92 (95% CI, 1.42-2.60). Additionally, women in the inland area had a consistently higher prevalence of psychological distress compared to those from the 13 regional centers: OR 1.67 (95% CI, 1.18-2.38) to 2.19 (95% CI, 1.60-2.99). CONCLUSIONS: The lack of pre-disaster data in the Japan Environment and Children's Study made it impossible to compare the incidence of psychological distress before and after the March 2011 Great East Japan Earthquake. However, 3 years after the Great East Japan Earthquake, the prevalence of pregnant women with psychological distress did not improve in Miyagi Regional Center. Further, the prevalence of mental illness in inland areas was consistently higher than that in the 13 regional centers after the disaster.
Questionnaire survey on pharyngolaryngeal sensation evaluation regarding dysphagia in Japan

Tomonori Kambayashi, Kengo Kato, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Ai Hirano-Kawamoto, Jun Ohta, Hitoshi Kagaya, Makoto Inoue, Masamitsu Hyodo, Koichi Omori, Atsushi Suehiro, Tatsuma Okazaki, Shin-Ichi Izumi, Shigeto Koyama, Keiichi Sasaki, Yoshihiko Kumai, Takaharu Nito, Shinichi Kuriyama, Takenori Ogawa, Yukio Katori

Auris Nasus Larynx　2021/02
Publisher: Elsevier BV
DOI： 10.1016/j.anl.2021.01.022 　

ISSN： 0385-8146
Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study. Peer-reviewed

Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto

Journal of epidemiology　31　(1)　65-76　2021/01/05

DOI： 10.2188/jea.JE20190271 　

ISSN： 0917-5040

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BACKGROUND: We established a community-based cohort study to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on the incidence of major diseases, such as cancer and cardiovascular diseases. METHODS: We asked participants to join our cohort in the health check-up settings and assessment center based settings. Inclusion criteria were aged 20 years or over and living in Miyagi or Iwate Prefecture. We obtained information on lifestyle, effect of disaster, blood, and urine information (Type 1 survey), and some detailed measurements (Type 2 survey), such as carotid echography and calcaneal ultrasound bone mineral density. All participants agreed to measure genome information and to distribute their information widely. RESULTS: As a result, 87,865 gave their informed consent to join our study. Participation rate at health check-up site was about 70%. The participants in the Type 1 survey were more likely to have psychological distress than those in the Type 2 survey, and women were more likely to have psychological distress than men. Additionally, coastal residents were more likely to have higher degrees of psychological distress than inland residents, regardless of sex. CONCLUSION: This cohort comprised a large sample size and it contains information on the natural disaster, genome information, and metabolome information. This cohort also had several detailed measurements. Using this cohort enabled us to clarify the long-term effect of the disaster and also to establish personalized prevention based on genome, metabolome, and other omics information.
Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. International-journal

Xue Li, Chiaki Ono, Noriko Warita, Tomoka Shoji, Takashi Nakagawa, Hitomi Usukura, Zhiqian Yu, Yuta Takahashi, Kei Ichiji, Norihiro Sugita, Natsuko Kobayashi, Saya Kikuchi, Yasuto Kunii, Keiko Murakami, Mami Ishikuro, Taku Obara, Tomohiro Nakamura, Fuji Nagami, Takako Takai, Soichi Ogishima, Junichi Sugawara, Tetsuro Hoshiai, Masatoshi Saito, Gen Tamiya, Nobuo Fuse, Shinichi Kuriyama, Masayuki Yamamoto, Nobuo Yaegashi, Noriyasu Homma, Hiroaki Tomita

Frontiers in psychiatry　12　799029-799029　2021

DOI： 10.3389/fpsyt.2021.799029 　

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In this study, the extent to which different emotions of pregnant women can be predicted based on heart rate-relevant information as indicators of autonomic nervous system functioning was explored using various machine learning algorithms. Nine heart rate-relevant autonomic system indicators, including the coefficient of variation R-R interval (CVRR), standard deviation of all NN intervals (SDNN), and square root of the mean squared differences of successive NN intervals (RMSSD), were measured using a heart rate monitor (MyBeat) and four different emotions including "happy," as a positive emotion and "anxiety," "sad," "frustrated," as negative emotions were self-recorded on a smartphone application, during 1 week starting from 23rd to 32nd weeks of pregnancy from 85 pregnant women. The k-nearest neighbor (k-NN), support vector machine (SVM), logistic regression (LR), random forest (RF), naïve bayes (NB), decision tree (DT), gradient boosting trees (GBT), stochastic gradient descent (SGD), extreme gradient boosting (XGBoost), and artificial neural network (ANN) machine learning methods were applied to predict the four different emotions based on the heart rate-relevant information. To predict four different emotions, RF also showed a modest area under the receiver operating characteristic curve (AUC-ROC) of 0.70. CVRR, RMSSD, SDNN, high frequency (HF), and low frequency (LF) mostly contributed to the predictions. GBT displayed the second highest AUC (0.69). Comprehensive analyses revealed the benefits of the prediction accuracy of the RF and GBT methods and were beneficial to establish models to predict emotions based on autonomic nervous system indicators. The results implicated SDNN, RMSSD, CVRR, LF, and HF as important parameters for the predictions.
両親と児の血圧値の関連についての横断的検討三世代コホート調査

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 目時弘仁, 菊谷昌浩, 栗山進一

Journal of Epidemiology　31　(Suppl.)　101-101　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画三世代コホート調査の進捗

小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 菊谷昌浩, 目時弘仁, 栗山進一

Journal of Epidemiology　31　(Suppl.)　105-105　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重三世代コホート調査

米沢祐大, 小原拓, 山下貴宏, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　31　(Suppl.)　95-95　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

高瀬雅仁, 中村智洋, 平田匠, 小暮真奈, 板橋芙美, 土屋菜歩, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　101-101　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Small for gestational age児を予測するリスクスコアの検討三世代コホート調査

岩間憲之, 小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 星合哲郎, 齋藤昌利, 目時弘仁, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　31　(Suppl.)　130-130　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画三世代コホート調査母子のベースライン調査プロファイル

菅原準一, 石黒真美, 大沼ともみ, 村上慶子, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　31　(Suppl.)　131-131　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
住環境の主観的評価と心理的苦痛との関連

菅野郁美, 長谷川兼一, 中村智洋, 土屋菜歩, 小暮真奈, 板橋芙美, 成田暁, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　143-143　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
妊娠前および妊娠中の穀物摂取量と出生時体重・低出生体重三世代コホート調査

米沢祐大, 小原拓, 山下貴宏, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 菅原準一, 鈴木重徳, 菅沼大行, 栗山進一

Journal of Epidemiology　31　(Suppl.)　95-95　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
脂肪量指数および除脂肪量指数の組み合わせとHbA1cとの関連

高瀬雅仁, 中村智洋, 平田匠, 小暮真奈, 板橋芙美, 土屋菜歩, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　101-101　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画地域住民コホート特定健診共同参加型対象者の基礎特性とがん罹患の関連

寳澤篤, 小原拓, 中村智洋, 板橋芙美, 小暮真奈, 成田暁, 土屋菜歩, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 布施昇男, 辻一郎, 呉繁夫

Journal of Epidemiology　31　(Suppl.)　116-116　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Small for gestational age児を予測するリスクスコアの検討三世代コホート調査

岩間憲之, 小原拓, 石黒真美, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 星合哲郎, 齋藤昌利, 目時弘仁, 菅原準一, 八重樫伸生, 栗山進一

Journal of Epidemiology　31　(Suppl.)　130-130　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
東北メディカル・メガバンク計画三世代コホート調査母子のベースライン調査プロファイル

菅原準一, 石黒真美, 大沼ともみ, 村上慶子, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 小原拓, 栗山進一

Journal of Epidemiology　31　(Suppl.)　131-131　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
住環境の主観的評価と心理的苦痛との関連

菅野郁美, 長谷川兼一, 中村智洋, 土屋菜歩, 小暮真奈, 板橋芙美, 成田暁, 平田匠, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology　31　(Suppl.)　143-143　2021/01
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia.

Yasuo Uchida, Tomoya Higuchi, Matsuyuki Shirota, Satoshi Kagami, Daisuke Saigusa, Seizo Koshiba, Jun Yasuda, Gen Tamiya, Shinichi Kuriyama, Kengo Kinoshita, Nobuo Yaegashi, Masayuki Yamamoto, Tetsuya Terasaki, Junichi Sugawara

Biological & pharmaceutical bulletin　44　(6)　804-815　2021

DOI： 10.1248/bpb.b20-01043 　

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The purpose of the present study was to identify a plasma protein biomarker able to predict pre-eclampsia (PE). Comprehensive quantitative proteomics using mass spectrometry with sequential window acquisition of all theoretical fragment ion spectra (SWATH-MS) was applied to plasma samples of 7 PE and 14 healthy pregnant women (for PE subjects, plasma samples were taken before onset of PE), and 11 proteins were selected as candidates potentially able to differentiate the two groups. Plasmas collected at gestational weeks 14-24 from 36 PE and 120 healthy pregnant women (for PE subjects, plasma samples were taken before onset of PE) were used to conduct selected reaction monitoring quantification analysis, optimize protein combinations and conduct internal validation, which consisted of 30 iterations of 10-fold cross-validation using multivariate logistic regression and receiver operating characteristic (ROC) analysis. The combination of afamin, fibronectin, and sex-hormone-binding globulin was selected as the best candidate. The 3-protein combination predictive model (predictive equation and cut-off value) generated using the internal validation subjects was successfully validated in another group of validation subjects (36 PE and 54 healthy (for PE subjects, plasma samples were taken before onset of PE)) and showed good predictive performance, with the area under the curve (AUC) 0.835 and odds ratio 13.43. In conclusion, we newly identified a 3-protein combination biomarker and established a predictive equation and cut-off value that can predict the onset of PE based on analysis of plasma samples collected during gestational weeks 14-24.
Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study.

Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, Naoki Nakaya, Ryohei Sasaki, Nobuyuki Takanashi, Kiyomi Sakata, Kozo Tanno, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Journal of epidemiology　32　(5)　221-227　2020/12/26

DOI： 10.2188/jea.JE20200384 　

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BACKGROUND: Alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) are enzymes associated with diabetes mellitus (DM) prevalence. However, limited information is available regarding the association of liver enzymes and DM consistently present in obese and non-obese individuals. We examined whether the combination of ALT and GGT enzymes is associated with the prevalence of DM regardless of obesity in a general Japanese population. METHODS: We conducted a cross-sectional study of 62,786 participants aged ≥20 years who lived in Miyagi and Iwate, Japan. We divided all the participants into eight groups according to the ALT level (low: <30 IU/L and high: ≥30 IU/L), GGT level (low: <50 IU/L and high: ≥50 IU/L), and the presence of obesity. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression analysis, adjusting for potential confounders, to determine associations of the combination of ALT and GGT levels and obesity with DM prevalence. RESULTS: Overall, 6,008 participants (9.6%) had DM. Compared to non-obese individuals with low ALT and GGT levels, the participants with high ALT and GGT levels had high ORs for DM in both obese (OR 4.06; 95% CI, 3.61-4.56) and non-obese groups (OR 2.19; 95% CI, 1.89-2.52). The obese group had high ORs for DM, even at low ALT and GGT levels. CONCLUSION: High ALT and GGT levels are associated with DM prevalence in obese and non-obese participants. This finding suggests that correcting ALT and GGT levels and controlling obesity are important for the prevention of DM.
東北メディカル・メガバンク計画(宮城)における頸動脈エコーについて

寳澤篤, 土屋菜歩, 中村智洋, 宇留野晃, 栗山進一, 菅原準一, 呉繁夫, 布施昇男, 山本雅之

超音波医学　47　(Suppl.)　S532-S532　2020/11
Publisher: (公社)日本超音波医学会
ISSN： 1346-1176

eISSN： 1881-9311
Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children's Study (JECS). International-journal

Noriyuki Iwama, Takashi Sugiyama, Hirohito Metoki, Masatoshi Saito, Tetsuro Hoshiai, Zen Watanabe, Kosuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Hidekazu Nishigori, Shin-Ichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Diabetes research and clinical practice　169　108377-108377　2020/11

DOI： 10.1016/j.diabres.2020.108377 　

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AIMS: To investigate the associations between glycosylated hemoglobin (HbA1c) levels at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan. METHODS: This was a prospective nationwide birth cohort study of 77,526 subjects with an HbA1c level of <6.5% (<48 mmol/mol) at less than 24 weeks of gestation. Associations of HbA1c level with adverse pregnancy outcomes were evaluated using multivariate analyses. RESULTS: The adjusted odds ratios per 1% (11 mmol/mol) increase in HbA1c level were 1.77 (95% confidence interval [CI]: 1.48-2.12) for hypertensive disorders of pregnancy; 1.78 (95% CI: 1.12-2.83) for placental abruption; 1.30 (95% CI: 1.12-1.50) for preterm birth; 2.11 (95% CI: 1.41-3.16) for very preterm birth; 1.49 (95% CI: 1.33-1.68) for low birth weight infants; 1.95 (95% CI: 1.42-2.70) for macrosomia; 1.23 (95% CI: 1.09-1.39) for small for gestational age; 1.15 (95% CI: 1.04-1.28) for large for gestational age; and 1.29 (95% CI: 1.20-1.39) for the composite adverse pregnancy outcome. CONCLUSIONS: The higher the HbA1c level, the higher the risk of adverse pregnancy outcomes in Japan. Further studies will be needed to determine prenatal management based on the HbA1c level in pregnant women with HbA1c <6.5% (<48 mmol/mol) at less than 24 weeks of gestation.
Comparison among research, home, and office blood pressure measurements for pregnant women: The TMM BirThree Cohort Study. International-journal

Takuma Usuzaki, Mami Ishikuro, Hirohito Metoki, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Masahiro Kikuya, Taku Obara, Shinichi Kuriyama

Journal of clinical hypertension (Greenwich, Conn.)　22　(11)　2004-2013　2020/11

DOI： 10.1111/jch.14050 　

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Blood pressure (BP) measurements of pregnant women have been collected in offices and at home for previous research. However, it remains uncertain whether there is difference between research BP, defined as BP measured for the purpose of epidemiological research and BP measured at home or in an office. Therefore, the present study aimed to compare research BP with home and unstandardized office BP. Research, home, and office BP were measured among pregnant women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Research BP was measured twice at our research center while the participant was seated and after resting for 1-2 minutes. Research, home, and office BP were compared and agreement among the values was assessed. Differences among research, home, and office BP values and possible factors affecting differences were analyzed. Among 656 pregnant women, the mean (± standard deviations) research systolic (S), diastolic (D) BP, home SBP, home DBP office SBP, and office DBP were 103.8 ± 8.5, 61.8 ± 7.3, 104.4 ± 9.2, 61.2 ± 6.8, 110.5 ± 10.8, and 63.8 ± 8.7mmHg, respectively. Research SBP value was lower than home value (P = .0072; difference between mean research and home BP: -0.61 ± 7.8 mmHg). Research SBP and DBP values were lower than office values (P < .0001 for both SBP and DBP; means ± standard deviations of differences between research and office BP: 6.7 ± 10.1 and 2.0 ± 8.5 mmHg for SBP and DBP, respectively). In conclusion, when research BP is measured under conditions controlled, research BP can give close values to home BP for pregnant women.
Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. International-journal Peer-reviewed

Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Takumi Hirata, Akira Narita, Hirohito Metoki, Mami Ishikuro, Masahiro Kikuya, Kozo Tanno, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Masayuki Yamamoto, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

Hypertension research : official journal of the Japanese Society of Hypertension　43　(11)　1277-1283　2020/11

DOI： 10.1038/s41440-020-0463-8 　

ISSN： 0916-9636

eISSN： 1348-4214
Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, Keiko Murakami, Masahiro Kikuya, Fumihiko Ueno, Aoi Noda, Satoshi Mizuno, Tomoko Kobayashi, Yohei Hamanaka, Kichiya Suzuki, Eiichi Kodama, Naho Tsuchiya, Akira Uruno, Yoichi Suzuki, Osamu Tanabe, Hideyasu Kiyomoto, Akito Tsuboi, Atsushi Shimizu, Seizo Koshiba, Naoko Minegishi, Soichi Ogishima, Gen Tamiya, Hirohito Metoki, Atsushi Hozawa, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama, Masayuki Yamamoto

Journal of epidemiology　32　(2)　69-79　2020/10/10

DOI： 10.2188/jea.JE20200338 　

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BACKGROUND: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. METHODS: Expectant mothers living in Miyagi prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. RESULTS: A total of 23 406 pregnancies involving 23 730 fetuses resulted in 23 143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes and hypertensive disorders of pregnancy. CONCLUSIONS: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.
Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Birth defects research　112　(16)　1224-1233　2020/10

DOI： 10.1002/bdr2.1748 　

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BACKGROUND: The aim of this study was to evaluate the prevalence of folic acid (FA) prescription to prenatal and postpartum women who have also been prescribed antiepileptic drugs (AED) in Japan. METHODS: The data set used in this study included women covered by health insurance between 2005 and 2016. The prevalence of FA prescriptions between 180 days before pregnancy and 180 days postpartum was determined from a large administrative database, with the FA prescription classified according to dose and timing. RESULTS: For 33,941 women meeting our eligibility criteria, the mean maternal age at delivery was 32.3 years. At least one AED was prescribed to 225 of 33,941 women between 180 days before pregnancy and 180 days postpartum. FA was prescribed to 32 of 225 women (14.2%) during the same period. FA was prescribed to 8.8% of women with AED within 90 days before pregnancy and to 19.8% during the first trimester. FA was prescribed to 10.9% during the first 30 days after conception, all of whom were prescribed FA before the pregnancy. The maximum FA dose prescribed within 90 days before pregnancy was 5 mg/day for 5 of 12 women (41.7%) and >5 mg/day for 4 of 12 women (33.3%). The maximum FA dose prescribed during the first trimester was 5 mg/day for 14 of 22 women (63.6%) and >5 mg/day for 8 of 22 women (36.4%). CONCLUSIONS: The concurrent prescription of FA with AEDs in Japan was an uncommon therapeutic approach both before and during pregnancy.
Social predictors of continued and indoor smoking among partners of non-smoking pregnant women: the TMM BirThree Cohort Study.

Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Taku Obara, Shinichi Kuriyama

Journal of epidemiology　31　(12)　635-641　2020/09/19

DOI： 10.2188/jea.JE20200313 　

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BACKGROUND: Secondhand smoke (SHS) from partners is a major source of exposure for non-smoking women. However, epidemiological studies have rarely examined social factors associated with continued and indoor smoking among pregnant women's partners. METHODS: We analyzed data on 6091 partners of non-smoking pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Partners' age, education, income, workplace SHS exposure (almost never or sometimes, almost every day), and pregnant women's smoking history (never, quit before pregnancy awareness, quit after pregnancy awareness) were used as social factors. Multivariate logistic regression analyses were conducted to examine the associations of social factors with partners' continued smoking and indoor smoking. RESULTS: Among 2432 smoking partners, 2237 continued to smoke after pregnancy awareness. Workplace SHS exposure was associated with increased risk of partners' continued smoking: the odds ratio of workplace SHS exposure almost every day compared with almost never or sometimes was 2.08 (95% confidence interval, 1.52-2.83). Women's quitting smoking after-but not before-pregnancy awareness was associated with decreased risk of partners' continued smoking: the odds ratio of women's quitting after pregnancy awareness compared with never smoking was 0.57 (95% confidence interval, 0.40-0.80). About one-third of partners who continued to smoke did so indoors. Older age, lower education, workplace SHS exposure, and women's quitting smoking after pregnancy awareness were associated with increased risk of partners' indoor smoking. CONCLUSIONS: Workplace SHS exposure and pregnant women's smoking history were associated with continued smoking and indoor smoking among partners of non-smoking pregnant women.
Associations of Education and Income With Secondhand Smoke Exposure Among Non-Smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, Shinichi Kuriyama

2020/09/03
Publisher: Research Square
DOI： 10.21203/rs.3.rs-64032/v1 　

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<title>Abstract</title> <bold>Background:</bold> Associations of education and income with secondhand smoke (SHS) exposure have been well documented in the general population. However, evidence among non-smoking pregnant women is limited, including in Japan. The purpose of the study was to examine the associations of education and income with SHS exposure among non-smoking pregnant women in Japan.<bold>Methods:</bold> We analyzed data from 17815 non-smoking pregnant women in Japan who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SHS exposure was defined as indoor exposure to someone else’s cigarette smoke ≥1 day/week during pregnancy. Multiple logistic regression analyses were conducted to examine whether pregnant women’s educational attainment or equivalent household income was associated with SHS exposure, adjusting for age, work status, smoking history, partners’ education, and income/education. Stratified analyses by work status were also conducted.<bold>Results:</bold> The prevalence of SHS exposure during pregnancy was 34.0%; 29.4% among non-working women and 37.1% among working women. Lower educational attainment was associated with an increased risk of SHS exposure; the odds ratio of high school education or lower compared with university education or higher was 1.78 (95% confidence interval, 1.59–1.99). Lower equivalent household income was associated with an increased risk of SHS exposure; the odds ratio of the lowest compared with the highest level of income was 1.67 (95% confidence interval, 1.51–1.84). These associations did not differ between non-working women and working women.<bold>Conclusions:</bold> Pregnant women with lower education and/or lower household income had higher risks of SHS exposure in Japan. These findings imply that educational interventions and financial incentives are needed for pregnant women and their household smokers in helping to reduce SHS exposure among non-smoking pregnant women.
【周産期メンタルヘルスの今】東北メディカル・メガバンク事業出生コホートを起点とした産後うつ病研究

菊地紗耶, 小林奈津子, 小野千晶, 割田紀子, 村上慶子, 小原拓, 長神風二, 栗山進一, 富田博秋

精神医学　62　(9)　1245-1251　2020/09
Publisher: (株)医学書院
ISSN： 0488-1281

eISSN： 1882-126X
How can we evaluate whether an association is truly inter-generational? International-journal

Takuma Usuzaki, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Taku Obara, Shinichi Kuriyama

Journal of hypertension　38　(9)　1866-1868　2020/09

DOI： 10.1097/HJH.0000000000002507 　
Clustering by phenotype and genome-wide association study in autism. International-journal Peer-reviewed

Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, Gen Tamiya, Masao Ueki, Rieko Sakurai, Satoshi Makino, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Hiroko Matsubara, Yasutaka Kuniyoshi, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomoko Kobayashi, Mika Kobayashi, Takuma Usuzaki, Hisashi Ohseto, Atsushi Hozawa, Masahiro Kikuya, Hirohito Metoki, Shigeo Kure, Shinichi Kuriyama

Translational psychiatry　10　(1)　290-290　2020/08/17
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41398-020-00951-x 　

ISSN： 2158-3188

eISSN： 2158-3188

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Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex Collection (SSC). As a preliminary study, we conducted a conventional genome-wide association study (GWAS) with a data set of 597 ASD cases and 370 controls. In the second step, we divided cases based on the clustering results and conducted GWAS in each of the subgroups vs controls (cluster-based GWAS). We also conducted cluster-based GWAS on another SSC data set of 712 probands and 354 controls in the replication stage. In the preliminary study, which was conducted in conventional GWAS design, we observed no significant associations. In the second step of cluster-based GWASs, we identified 65 chromosomal loci, which included 30 intragenic loci located in 21 genes and 35 intergenic loci that satisfied the threshold of P < 5.0 × 10-8. Some of these loci were located within or near previously reported candidate genes for ASD: CDH5, CNTN5, CNTNAP5, DNAH17, DPP10, DSCAM, FOXK1, GABBR2, GRIN2A5, ITPR1, NTM, SDK1, SNCA, and SRRM4. Of these 65 significant chromosomal loci, rs11064685 located within the SRRM4 gene had a significantly different distribution in the cases vs controls in the replication cohort. These findings suggest that clustering may successfully identify subgroups with relatively homogeneous disease etiologies. Further cluster validation and replication studies are warranted in larger cohorts.
Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. International-journal Peer-reviewed

Maiko Wagata, Mami Ishikuro, Taku Obara, Masato Nagai, Satoshi Mizuno, Naoki Nakaya, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Hirohito Metoki, Soichi Ogishima, Atsushi Hozawa, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama, Junichi Sugawara

Pregnancy hypertension　22　119-125　2020/08/05

DOI： 10.1016/j.preghy.2020.08.001 　

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Low birth weight is known to be associated with hypertension, cardiovascular disease and hypertensive disorders of pregnancy (HDP); however, this association might vary by race/ethnicity. This study aimed to clarify the association between women's own birth weight and their subsequent risk for HDP in a Japanese population, in combination with pre-pregnancy body mass index (BMI). We conducted a cohort study as part of the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Miyagi, Japan. Our study's population included 4810 women. A multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (aOR) and the 95% confidence interval (CI) of the women's own birth weight for HDP, in the combination categories of birth weight and pre-pregnancy BMI. As a result, the group with a low birth weight of <2500 g had a significant association with HDP (the aOR, 1.50; 95% CI, 1.02-2.21). In the subtype analysis, the odds ratio for only preeclampsia was significantly increased in the low birth weight group (aOR, 3.37; 95% CI, 1.84-6.16). In the group with a low birth weight, the prevalence of HDP was higher in both the underweight and overweight groups. In conclusion, there was a significant association between low birth weight and subsequent HDP in Japanese women. Furthermore, a significant association with HDP was found for women born with a low birth weight who were underweight or overweight as adults. Maintaining a normal weight may be effective for preventing HDP even if a woman was born small.
Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study. International-journal Peer-reviewed

Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Junichi Sugawara, Mami Ishikuro, Keiko Murakami, Aoi Noda, Fumihiko Ueno, Shigenori Suzuki, Hiroyuki Suganuma, Shinichi Kuriyama

Nutrition journal　19　(1)　80-80　2020/08/03

DOI： 10.1186/s12937-020-00595-z 　

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BACKGROUND: Associations of fruit and vegetable consumption before and during pregnancy with birth weight of new-borns and the risk of low birth weight (LBW) remain unclear. METHODS: Between July 2013 and March 2017, we recruited 23,406 pregnant women in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). Fruit and vegetable consumption before and during pregnancy was calculated using food frequency questionnaires. Information regarding birth weight was obtained from medical records, and LBW was defined as < 2500 g. We used a multivariable linear regression model and a multivariate logistic regression model to assess associations between fruit and vegetable consumption and birth weight/risk of LBW. RESULTS: In total, 17,610 women were included in the analysis. Mean birth weight was 3061.8 ± 354.1 g, and 5.4% of the new-borns had LBW. Compared to women in the lowest quartile of fruit consumption between pre- and early pregnancy, women in the highest quartile had heavier new-borns (β = 49.4; 95% CI: 34.1-64.7) and lower risk of LBW (OR: 0.79; 95% CI: 0.65-0.95). Women in the highest quartile of fruit consumption from early to mid-pregnancy also had heavier new-borns (β = 32.3; 95% CI: 17.1-47.6), and they tended to have lower risk of LBW (OR: 0.83; 95% CI: 0.69-1.01). Results of analysing the association between changes in fruit consumption from pre- to mid-pregnancy and birth outcomes revealed that women with continuous high fruit consumption from pre- to mid-pregnancy had heavier new-borns (β = 37.6; 95% CI: 25.0-50.3), but they did not have lower risk of LBW (OR: 0.90; 95% CI: 0.77-1.06). Associations involving vegetable consumption and birth weight/risk of LBW were not observed. CONCLUSIONS: Fruit consumption before and during pregnancy was positively associated with birth weight of new-borns and negatively associated with risk of LBW.
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
宮城県初の5歳児発達健診東北メディカル・メガバンク計画における三世代コホート調査参加児を対象とする予備的調査

小林朋子, 小林美佳, 栗山進一, 呉繁夫

脳と発達　52　(Suppl.)　S297-S297　2020/08
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
非喫煙者における家庭での受動喫煙と高血圧の関連東北メディカル・メガバンク計画地域住民コホート調査より

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

厚生の指標　67　(8)　1-8　2020/08
Publisher: (一財)厚生労働統計協会
ISSN： 0452-6104
産後うつ病の予測と予防のための血漿サイトカインレベルの検証

兪志前, 小野千晶, 小原拓, 菊地沙耶, 小林奈津子, 菅原準一, 栗山進一, 山本雅之, 八重樫伸生, 富田博秋

日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集　50回・42回・4回　195-195　2020/08
Publisher: 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会
Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children's Study. International-journal Peer-reviewed

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　2789-2796　2020/08

DOI： 10.1080/14767058.2018.1560414 　

ISSN： 1476-7058

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Objective: To survey the frequency and risk factors for father-to-infant lack of affection (LA) and anger/rejection (AR) bonding failure at 1 month postpartum.Material and methods: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment & Children's Study. Bonding failure, psychological distress during pregnancy and postnatal depression symptoms were evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J), the Kessler 6-item (K6) psychological distress scale and the Edinburgh Postnatal Depression Scale (EPDS-J). This study extracted relative factors based on approximately 10% occupancy of the total high scores in MIBS-J subscales as a cut-off for bonding failure. The cut-off scores on the paternal EPDS-J were eight, on maternal EPDS-J was 9, and on the K6 psychological distress scale score was 13.Results: A total of 1008 couples who had single delivery were assessed at 1 month postpartum, respectively. The prevalence of paternal MIBS-J_LA scores ≥4 was 8.3%, MIBS-J_AR scores ≥3 was 7.9%, and EPDS-J scores ≥8 was 11.2%, respectively. In the multiple logistics analysis, paternal MIBS-J_LA scores ≥4 were significantly associated with maternal MIBS-J_LA score ≥3 (adjusted odds ratio (AOR) 2.814; 95% confidence interval (CI): 1.377-5.747), mental intimate partner violence (IPV) against the mother during pregnancy (AOR 2.176; 95% CI: 1.185-3.997), maternal K6 psychological distress scale score ≥13 (AOR 2.980; 95% CI: 1.317-6.745), paternal EPDS-J score ≥8 (AOR 3.227; 95% CI: 1.767-5.892), and a history of mental health disorder (AOR 4.125; 95% CI: 1.423-11.963). Paternal MIBS-J_AR scores ≥3 were significantly associated with maternal MIBS-J_AR scores ≥3 (AOR 5.082; 95% CI: 2.453-10.529), a history of physical IPV against the mother during pregnancy (AOR 5.230; 95% CI: 1.016-26.920), paternal K6 psychological distress scale score ≥13 (AOR 4.145; 95% CI: 1.311-13.107), and paternal EPDS-J scores ≥8 (AOR 4.479; 95% CI: 2.503-8.013). In Pearson's product moment correlation coefficient analyses between paternal and maternal MIBS-J score, MIBS-J_LA score was r = 0.2112, p < .0001, and MIBS-J_AR score was r = 0.3281, p < .0001.Conclusion: Father-to-infant lack of affection bonding failure was associated with mother-to-infant lack of affection bonding failure, mental IPV against mother during pregnancy, maternal psychological distress during pregnancy, paternal postpartum depression symptoms, and history of paternal mental health disorders. Father-to-infant anger/rejection bonding failure was associated with mother-to-infant anger/rejection bonding failure, physical IPV against mother during pregnancy, paternal psychological distress during pregnancy, and paternal postpartum depression symptoms. Since bonding failure is a risk factor for infant maltreatment, further investigations are recommended to fully assess these associations to resolve parent perinatal mental health issues for preventing father-to-infant bonding failure.
The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study. International-journal Peer-reviewed

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Satoshi Mizuno, Mami Ishikuro, Kasumi Sakurai, Hirotaka Hamada, Zen Watanabe, Tetsuro Hoshiai, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nobuo Yaegashi

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(16)　2797-2804　2020/08

DOI： 10.1080/14767058.2018.1560415 　

ISSN： 1476-7058

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Objective: To survey prevalence and risk factors for paternal postpartum depression symptoms at one and 6 months postpartum in Japan.Material and methods: The study participants enrolled in the prospective birth cohort study of an adjunct study of the Japan Environment and Children's Study. Postpartum depression symptoms were evaluated using the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS-J). The cut-off scores on the paternal EPDS-J were eight and on maternal EPDS-J was nine, respectively. The multivariate logistic regression included an adjustment for paternal age, maternal age, the number of children in the family, family structure, paternal employment, paternal academic history, household income, paternal smoking status, paternal history of mental health disorders, the Kessler 6-item psychological distress scale (K6) score during pregnancy, infertility treatment, paternal mental intimate partner violence (IPV) during pregnancy, paternal physical IPV during pregnancy, the sex of the newborn, congenital anomalies of the newborn, infant disease under medical treatment, returning to the maternal parent's house to give birth or take care of infant, the father's history of disease or injury that required medical treatment, paternity leave, and the EPDS-J for mothers.Results: A total of 1023 and 1330 fathers and their spouse who had a single delivery were assessed at one and 6 months postpartum, respectively. The prevalence of paternal EPDS-J scores ≥8 was 11.2 and 12.0% at one and 6 months postpartum, respectively. In the multiple logistics analysis, paternal EPDS-J scores ≥8 at 1 month postpartum was significantly associated with history of mental health disorders (adjusted odds ratio (AOR) 2.825; 95% confidence interval (CI): 1.047-7.623), K6 score ≥13 during pregnancy (AOR 4.116; 95% CI: 1.598-10.599), household income <4000 × 103 yen (AOR 1.799; 95% CI: 1.072-3.021), and infant disease under medical treatment (AOR 1.720; 95% CI: 1.015-2.915). Paternal EPDS-J scores ≥8 at 6 months postpartum was significantly associated with K6 scores ≥13 during pregnancy (AOR 4.621; 95% CI: 2.113-10.107), unemployment (AOR 3.751; 95% CI: 1.739-8.091) and maternal EPDS-J scores ≥9 (AOR 2.460; 95% CI: 1.514-3.996).Conclusion: The prevalence of paternal postpartum depression symptoms were 11.2 and 12.0% at one and 6 months postpartum. Paternal postpartum depression symptoms at 1 month postpartum were associated with the history of mental health disorders, psychological distress during pregnancy, low income, and infant disease under medical treatment. Paternal postpartum depression symptoms at 6 months postpartum were associated with psychological distress during pregnancy, unemployment, and maternal postpartum depression. It is important to consider the paternal postpartum depression symptoms, and further enlightenment regarding these issues is recommended in Japan.
Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3. International-journal

Ren Yoshitomi, Kai Nakayama, Shuya Yamashita, Motofumi Kumazoe, Ting-An Lin, Chen-Yi Mei, Yuki Marugame, Yoshinori Fujimura, Mari Maeda-Yamamoto, Shinichi Kuriyama, Hirofumi Tachibana

Scientific reports　10　(1)　10283-10283　2020/06/24

DOI： 10.1038/s41598-020-67288-9 　

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Folic acid and folate receptors (FOLRs) play an important role in the downregulation of homocysteine (Hcy), a risk factor of Alzheimer's disease, thrombosis, neuropsychiatric illness and fractures. While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown. In this study, we evaluated the impact of FOLR3 on the metabolism of Hcy alongside its protective effect against homocysteine-induced neurotoxicity. To reveal the role of FOLR3, we constructed FOLR3-overexpressed HEK293 cells (FOLR3+ cells) and evaluated cell growth, folic acid intake and Hcy-induced neurotoxicity. Subjects with a high expression of FOLR3 exhibited low levels of plasma homocysteine. The ectopic expression of FOLR3 enhanced cell growth, and the enhanced effect was neutralised by folic acid-deficient media. The Western blot analysis revealed that FOLR3 is secreted into cell supernatant. The folic acid intake of FOLR3+ cells was higher than that of wild-type cells. Supernatant from FOLR3+ cells showed a protective effect on Hcy-induced cytotoxicity. FOLR3 expression in plasma is negatively correlated with plasma homocysteine. Our study emphasizes the role of FOLR3 in the intake of folic acid into cells on the one hand and its protective role in Hcy-induced cytotoxicity on the other.
Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project.

Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, Akihito Otsuki, Junko Kawashima, Tomomi Kiyama, Toru Tamahara, Maki Goto, Shihoko Koyama, Junichi Sugawara, Eiichi N Kodama, Hirohito Metoki, Atsushi Hozawa, Shinichi Kuriyama, Hiroaki Tomita, Masahiro Kikuya, Naoko Minegishi, Kichiya Suzuki, Seizo Koshiba, Gen Tamiya, Nobuo Fuse, Yuichi Aoki, Takako Takai-Igarashi, Soichi Ogishima, Tomohiro Nakamura, Mika Sakurai-Yageta, Fuji Nagami, Kengo Kinoshita, Shigeo Kure, Ritsuko Shimizu, Keiichi Sasaki, Masayuki Yamamoto

The Tohoku journal of experimental medicine　251　(2)　97-115　2020/06

DOI： 10.1620/tjem.251.97 　

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In order to assess the long-term impact of the Great East Japan Earthquake on the oral health of disaster victims and to evaluate gene-environmental interactions in the development of major oral diseases and oral-systemic associations, the oral part of two large-scale genome cohort studies by the Tohoku Medical Megabank Organization (ToMMo), including the Community-based cohort (CommCohort) study and the Birth and Three-Generation cohort (BirThree) study, have been conducted. The study population comprised 32,185 subjects, including 16,886 participants in the CommCohort study and 15,299 participants in the BirThree cohort study, recruited from 2013 to 2017. The oral studies consist of a questionnaire regarding oral hygiene behavior, clinical examinations by dentists, and oral plaque and saliva sampling for microbiome analyses, which were carried out at seven community support centers in Miyagi prefecture. The median age of all participants was 55.0 years, and 66.1% of participants were women. Almost all participants reported that they brushed their teeth more than once a day. The median number of present teeth was 27.0, and the decayed, missing and filled tooth number was 16.0, with a significant difference according to age and sex. The median periodontal pocket and clinical attachment level was 2.48 mm and 4.00 mm, respectively. Periodontal parameters increased significantly according to age, except for the accumulation of dental calculus. The oral part of these extensive cross-sectional studies provides a unique and important platform for future studies on oral health and diseases that elicit through interactions with systemic diseases, lifestyles, life events and genetic backgrounds, and contributes to researches clarifying the long-term effects of disasters on oral health.
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. International-journal Peer-reviewed

Noriyuki Iwama, Mari S Oba, Michihiro Satoh, Takayoshi Ohkubo, Mami Ishikuro, Taku Obara, Satomi Sasaki, Masatoshi Saito, Yoshitaka Murakami, Shin-Ichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　43　(6)　550-559　2020/06

DOI： 10.1038/s41440-020-0416-2 　

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This study investigated the association between maternal home blood pressure (HBP) trajectory during pregnancy and infant birth weight. A total of 755 pregnant women were included in this prospective cohort study. A group-based trajectory model identified six trajectory groups for home systolic blood pressure (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Next, the association of HBP trajectory groups with infant birth weight was evaluated using a general linear model considering potential confounding factors. For home SBP and MAP, the trajectory groups with a low-steep J-curve, moderate J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the low-J-curve group. Among the trajectory groups for home DBP, the moderate-steep J-curve, little high J-curve, and high J-curve were significantly associated with lower infant birth weight than the group with low-J-curve. The effect sizes of the trajectory groups varied in infant birth weight from -0.21 standard deviations (SDs) (95% confidence interval (CI): -0.42 to -0.01 SD) to -1.13 SD (95% CI: -1.54 to -0.72 SD). In the analyses of infant birth weight in grams, effect sizes that were significantly associated with infant birth weight varied from -84 g (95% CI: -167 to -1 g) to -567 g (95% CI: -732 to -402 g). Trajectory groups with a moderate-reverse J-curve for home SBP, DBP, and MAP were not significantly associated with infant birth weight. Maternal HBP trajectory during pregnancy was an indicator of infant birth weight. Further studies evaluating the associations between HBP during pregnancy and other perinatal outcomes are needed.
Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy International-journal Peer-reviewed

Matsuyuki Shirota, Daisuke Saigusa, Riu Yamashita, Yasutake Kato, Mitsuyo Matsumoto, Junya Yamagishi, Noriko Ishida, Kazuki Kumada, Yuji Oe, Hisaaki Kudo, Junji Yokozawa, Yoko Kuroki, Ikuko Motoike, Fumiki Katsuoka, Masao Nagasaki, Seizo Koshiba, Keiko Nakayama, Osamu Tanabe, Jun Yasuda, Shigeo Kure, Kengo Kinoshita, Hirohito Metoki, Shinichi Kuriyama, Nobuo Yaegashi, Masayuki Yamamoto, Junichi Sugawara

Medical Mass Spectrometry　4　(1)　36-49　2020/04/16

DOI： 10.24508/mms.2020.06.001 　
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020/04
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
非喫煙妊婦における教育歴と受動喫煙の関連東北メディカル・メガバンク計画三世代コホート調査

村上慶子, 小原拓, 石黒真美, 上野史彦, 野田あおい, 大柳元, 菊谷昌浩, 目時弘仁, 栗山進一

宮城県公衆衛生学会会誌　(52)　22-22　2020/04
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク機構-地域住民コホート調査の進捗について

寳澤篤, 土屋菜歩, 平田匠, 小暮真奈, 成田暁, 中村智洋, 中谷直樹, 小原拓, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(52)　20-20　2020/04
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project.

Fuji Nagami, Miho Kuriki, Sachie Koreeda, Maiko Kageyama, Osamu Shimizu, Soichiro Toda, Atsushi Hozawa, Shinichi Kuriyama, Noriko Osumi, Masayuki Yamamoto

The Tohoku journal of experimental medicine　250　(4)　253-262　2020/04

DOI： 10.1620/tjem.250.253 　

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The Tohoku Medical Megabank Project was designed as part of the national reconstruction project for addressing the damage from the 2011 Great East Japan Earthquake. It is an integrated project involving the genome cohort study of 150,000 participants, integrated biobank construction, and multi-omics analyses. Public relations and communication activities emerged to be extremely important in the successful development of this project. To gain insights into the contributions of these activities, we divided the public relations and communication activities for the project into three phases based on the situations surrounding the project. Prior to the start of the cohort study (Phase I), a cooperative relationship was established with a focus on concluding cooperation agreements with local governments. Until the participants reached the target number (Phase II), we actively communicated with the media to publicize the project. During the phase in which use of the constructed biobank is promoted (Phase III), for ensuring the industrial utilization of the biobank, visits from the industry are promoted. Throughout the execution of these activities, we explored the best strategies for building relationships with multiple stakeholders like local government, media and industry. By paying attention to these phases that have been changing according to the project's progress, we were able to adapt the strategies and methods of public relations and communication. The success of these activities has enabled the overall project to progress smoothly. We hope that the process of designing our project's public relations and communication activities will be useful for other similar initiatives.
Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 µg per day: results from TMM BirThree Cohort Study. International-journal Peer-reviewed

Daisuke Kikuchi, Taku Obara, Takuma Usuzaki, Yudai Yonezawa, Takahiro Yamashita, Gen Oyanagi, Aoi Noda, Fumihiko Ueno, Keiko Murakami, Hiroko Matsubara, Mami Ishikuro, Hirohito Metoki, Masahiro Kikuya, Shinichi Kuriyama

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　35　(5)　1-6　2020/03/13

DOI： 10.1080/14767058.2020.1739020 　

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Objective: In Japan, supplementation with 400 µg of folic acid per day is recommended for women who are planning to get pregnant to decrease the risk of their babies getting neural tube defects (NTD). However, the proportion of women who have taken folic acid supplements before conception is low among Japanese pregnant women. In addition, the dietary intake of folic acid has not yet reached the government recommended dietary intake levels (480 µg per day). This study aimed to clarify the prevalence and determinants of adequate folic acid supplements among Japanese pregnant women with dietary folic acid intake lower than 480 µg per day.Methods: This cross-sectional study was a part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We collected information on folic acid supplements before conception, sociological/lifestyle characteristics, and food consumption. The primary outcome was the use of folic acid supplements (adequate or inadequate, based on the timing of initiation of folic acid supplements). Multiple logistic regression analysis was used to examine the association between sociological/lifestyle characteristics and the adequate intake of folic acid supplements.Results: Among the 11,562 pregnant women who took lower than 480 µg per day of folic acid from food, the prevalence of adequate users was 18.0%. Pregnant women who reported adequate use of folic acid supplements were more likely to be older and educated; and reported higher household income, and history of fertility treatment. Conversely, they were less likely to be ever or current smokers and multipara.Conclusion: This study found that the prevalence of folic acid supplements use for the prevention of NTD among Japanese pregnant women was still low.
Bootstrap法およびPermutation法の応用による三世代家族の身長、体重、BMIの世代間関連の評価三世代コホート調査

臼崎琢磨, 石黒真美, 村上慶子, 野田あおい, 上野史彦, 目時弘仁, 菊谷昌浩, 小原拓, 栗山進一

日本衛生学雑誌　75　(Suppl.)　S158-S158　2020/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
家系情報付き出生三世代コホートの構築に基づく成果の還元と試料・情報の分譲

小原拓, 村上慶子, 石黒真美, 上野史彦, 野田あおい, 菊谷昌浩, 目時弘仁, 栗山進一

日本衛生学雑誌　75　(Suppl.)　S158-S158　2020/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082

eISSN： 1882-6482
Antidepressant prescriptions for prenatal and postpartum women in Japan: A health administrative database study. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Saya Kikuchi, Natsuko Kobayashi, Keiko Miyakoda, Hidekazu Nishigori, Hiroaki Tomita, Manabu Akazawa, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Journal of affective disorders　264　295-303　2020/03/01

DOI： 10.1016/j.jad.2020.01.016 　

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BACKGROUND: The prevalence and pattern of perinatal antidepressant prescriptions in Japan are unknown. METHODS: The prevalence of antidepressant prescriptions between 180 days before pregnancy onset and 180 days postpartum was evaluated using a large administrative database. The dates of pregnancy onset and delivery were estimated using developed algorithms. RESULTS: Of 33,941 women, at least one antidepressant was prescribed to 451 (133/10,000 deliveries) between 180 days before pregnancy and 180 days postpartum and to 241 (71/10,000 deliveries) during pregnancy. The prevalence of antidepressant prescriptions decreased during the first and second trimesters and increased in the postpartum period. Of 339 women with antidepressant prescriptions before pregnancy, 151 (44.5%) discontinued it during pregnancy. Selective serotonin-reuptake inhibitors were the most frequently prescribed class of antidepressants in the time period studied (356 women, 105/10,000 deliveries), followed by tricyclic/non-tricyclic antidepressants (101 women, 30/10,000 deliveries). Of the 57 women who had at least one record of paroxetine prescription in the first trimester, 13 (22.8%) were prescribed >25 mg/day. Fifty-seven women (17/10,000 deliveries) were concurrently prescribed two or more classes of antidepressants between 180 days before pregnancy and 180 days postpartum. LIMITATIONS: It may not always have been the case that the prescribed antidepressants were used. Women whose pregnancy ended in an abortion or stillbirth were not included. CONCLUSIONS: Various antidepressants were prescribed to prenatal and postpartum women in Japan. Approximately half of pregnant women discontinued treatment with antidepressants after becoming pregnant. Women of childbearing age should select an appropriate antidepressant considering the risk/benefit profile.
糖尿病による推定糸球体濾過量(eGFR)の季節差

良知弘務, 土屋菜歩, 平田匠, 中村智洋, 栗山進一, 菅原準一, 辻一郎, 呉繁夫, 宮崎真理子, 寳澤篤

日本内分泌学会雑誌　95　(4)　1606-1606　2020/02
Publisher: (一社)日本内分泌学会
ISSN： 0029-0661

eISSN： 2186-506X
Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians　33　(3)　427-436　2020/02

DOI： 10.1080/14767058.2018.1494712 　

ISSN： 1476-7058

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Objective: To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions.Materials and methods: The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators.Results: Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions.Conclusions: Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International-journal Peer-reviewed

Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

International journal of epidemiology　49　(1)　18-19　2020/02/01

DOI： 10.1093/ije/dyz169 　

ISSN： 0300-5771
Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. International-journal

Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, Hiroyuki Matsui, Junko Kawashima, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Nobuo Fuse, Shigeo Kure, Riu Yamashita, Osamu Tanabe, Naoko Minegishi, Kengo Kinoshita, Akito Tsuboi, Ritsuko Shimizu, Masayuki Yamamoto

Frontiers in cellular and infection microbiology　10　604596-604596　2020

DOI： 10.3389/fcimb.2020.604596 　

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A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes Actinobacteria and Bacilli, including oral health-associated bacterial species, showed a positive correlation in saliva. These results revealed differences in microbial composition and community structure between saliva and plaque and a correlation between microbial species and the severity of periodontal disease. We expect that the large database of the oral microbiome in the TMM biobank will help in the discovery of novel targets for the treatment and prevention of oral diseases, as well as for the discovery of therapeutic and/or preventive targets of systemic diseases.
Effectiveness of seasonal inactivated influenza vaccination in Japanese schoolchildren: an epidemiologic study at the community level. International-journal Peer-reviewed

Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Masato Nagai, Keiko Murakami, Aoi Noda, Masahiro Kikuya, Shigeo Kure, Shinichi Kuriyama

Human vaccines & immunotherapeutics　16　(2)　295-300　2020

DOI： 10.1080/21645515.2019.1655833 　

ISSN： 2164-5515

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Influenza vaccination is the most effective method for preventing influenza virus infection. The incidence of influenza is higher in schoolchildren than other age groups. This study evaluated the effectiveness of seasonal inactivated influenza vaccination (IIV) in a community population of schoolchildren during two seasons. This study was a cross-sectional survey of public schoolchildren based on data collected in the 2012/2013 and 2014/2015 seasons. The questionnaire was distributed to all public schoolchildren of target grade in a survey area, and 7945 respondents were included in the analysis. The vaccination status and influenza onset were defined based on the self-reported questionnaire by parents or guardians. Generalized linear mixed models were used to adjust clustering within schools and individual covariates and calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between vaccination status and influenza onset. The influenza incidence was higher in the 2015 than the 2013 survey (25% versus 17%), although the vaccination rates were comparable between the two seasons. Receiving one- or two-dose vaccination was more protective against influenza than non-vaccination in both the 2013 (OR, 0.77; 95%CI, 0.65-0.92) and 2015 (OR, 0.88; 95%CI, 0.75-1.02) surveys. Full vaccination was also more protective in both the 2013 (OR, 0.75; 95%CI, 0.62-0.89) and 2015 (OR, 0.86; 95%CI, 0.74-1.00) surveys. Seasonal IIV was protective against influenza for Japanese schoolchildren in a community-based real-world setting. The difference in clinical effectiveness of IIV between the two seasons was likely due to the antigenic mismatch between the circulating and vaccine strains.
Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. International-journal Peer-reviewed

Takumi Hirata, Tomohiro Nakamura, Mana Kogure, Naho Tsuchiya, Akira Narita, Ken Miyagawa, Kotaro Nochioka, Akira Uruno, Taku Obara, Naoki Nakaya, Hirohito Metoki, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　23-29　2020/01

DOI： 10.1038/s41440-019-0329-0 　

ISSN： 0916-9636

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Few studies have reported the relationship between reduced sleep efficiency and the prevalence of hypertension independent of sleep duration in Japan. This study aimed to evaluate whether reduced sleep efficiency, measured using an objective device for >1 week, was related to an increased prevalence of hypertension independent of sleep duration in the general Japanese population. We conducted a cross-sectional study of 904 participants aged ≥20 years who lived in Miyagi Prefecture, Japan. Sleep efficiency was measured using a contactless biomotion sleep sensor for 10 continuous days. The participants were classified into two groups according to their sleep efficiency: reduced (<90%) or not reduced (≥90%). Hypertension was defined as morning home blood pressure ≥135/85 mmHg or self-reported treatment for hypertension. Multivariable logistic regression models were used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) to assess the relationship between sleep efficiency and hypertension adjusted for potential confounders. The results showed that two hundred and ninety-four individuals (32.5%) had reduced sleep efficiency, and 331 (36.6%) had hypertension. Individuals with reduced sleep efficiency had a higher body mass index and shorter sleep duration. In the multivariable analysis, reduced sleep efficiency was significantly related to an increased prevalence of hypertension (OR, 1.62; 95% CI, 1.15-2.28). In conclusion, reduced sleep efficiency was significantly related to an increased prevalence of hypertension in Japanese adults. Improvements in sleep efficiency may be important to reduce blood pressure in Japanese adults.
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. International-journal Peer-reviewed

Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Ichiro Tsuji, Shigeo Kure, Atsushi Hozawa

Hypertension research : official journal of the Japanese Society of Hypertension　43　(1)　62-71　2020/01

DOI： 10.1038/s41440-019-0335-2 　

ISSN： 0916-9636

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Previous studies have reported a positive association between the urinary sodium-to-potassium (Na/K) ratio and hypertension, and multiple measurements of the casual urinary Na/K ratio are more strongly correlated with the 24-h urinary Na/K ratio than a single measurement. Multiple measurements of the urinary Na/K ratio might be more strongly associated with hypertension. We aimed to determine the association between multiple measurements of the casual urinary Na/K ratio and home hypertension compared with a single measurement. A population-based cross-sectional study was performed in Miyagi Prefecture, Japan. Subjects were over 20 years old and participated in the Tohoku Medical Megabank Project Cohort Study. We targeted 3273 subjects who borrowed home blood pressure (HBP) monitors and urinary Na/K ratio monitors for 10 consecutive days. The association between the urinary Na/K ratio and home hypertension (HBP ≥ 135/85 mmHg or under treatment for hypertension) was examined using multiple logistic regression models. To compare the prediction of home hypertension using multiple measurements with that using a single measurement, we calculated the area under the receiver operating characteristic curve (AUROC). Multiple measurements of the urinary Na/K ratio strongly related to home hypertension were better than 1 or 2 days of measurement (adjusted odds ratio of home hypertension per unit increase in urinary Na/K ratio over 6 days: 1.13-1.15). The AUROC of the urinary Na/K ratio measurement for home hypertension was stable after 5 days (AUROC = 0.779). In conclusion, multiple measurements of the urinary Na/K ratio are strongly related to home hypertension. This finding suggests that multiple measurements of the urinary Na/K ratio are useful for evaluating home hypertension.
Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Peer-reviewed

Atsushi Hozawa, Takumi Hirata, Hiroshi Yatsuya, Yoshitaka Murakami, Shinichi Kuriyama, Ichiro Tsuji, Daisuke Sugiyama, Atsushi Satoh, Sachiko Tanaka-Mizuno, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura

Journal of epidemiology　29　(12)　457-463　2019/12/05

DOI： 10.2188/jea.JE20180124 　

ISSN： 0917-5040

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BACKGROUND: We sought to investigate the optimal values of BMI for the lowest risk of all-cause death and whether the optimal BMI differs according to smoking status in large-scale pooled analysis of 13 Japanese cohorts. METHODS: Data from 179,987 participants of 13 well-qualified cohort studies conducted throughout Japan were used for our analysis. A cohort-stratified Cox proportional hazard model was used. P values for interactions were calculated based on the cross product of BMI and age, sex, or smoking status. RESULTS: In the entire study population, all-cause mortality risk was lowest when the BMI was 22.0-24.9 kg/m2. This was also the case for selected healthy participants (never smoked, baseline total cholesterol level ≥4.1 mmol/L; the first 5 years of follow-up data were excluded). No effect modification of age, sex, or smoking status was observed. Regardless of their BMI, never smokers always had a lower all-cause mortality risk than did current smokers even with an ideal BMI in terms of mortality risk. CONCLUSION: A BMI of 22-24.9 kg/m2 correlated with the lowest risk of mortality, regardless of whether all participants or selected healthy participants were analyzed. The fact that smoking was more strongly associated with mortality than obesity emphasizes the urgency for effective anti-smoking programs.
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. International-journal Peer-reviewed

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Shinichi Kuriyama

Disaster medicine and public health preparedness　13　(5-6)　905-911　2019/12

DOI： 10.1017/dmp.2019.8 　

ISSN： 1935-7893

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OBJECTIVE: We aimed to investigate the association between types of housing and allergic symptoms at 3-4 years following the Great East Japan Earthquake. METHODS: Our study was based on the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey of public school children in Miyagi Prefecture, Japan. Of the 46 648 invited schoolchildren in the 2nd to 8th grades, 9884 were included. Presence of eczema, wheezing, and mental health symptoms was defined with questionnaires. To calculate odds ratios (ORs) and 95% CIs for the associations between types of housing and eczema or respiratory symptoms, we fitted generalized linear mixed models, included a random effect for municipality of residence, and adjusted for sex, school grade, survey year, and mental health symptoms. RESULTS: Prefabricated temporary housing was significantly associated with eczema symptoms (OR, 1.46; 95% CI, 1.06-2.02). Even after adjusting for the presence of mental health symptoms, our analysis produced similar results (OR, 1.42; 95% CI, 1.03-1.96). Conversely, it was not significantly associated with respiratory symptoms (OR, 0.97; 95% CI, 0.61-1.54). CONCLUSIONS: Children living in prefabricated temporary housing had a higher prevalence of eczema symptoms; however, prevalence of respiratory symptoms was not significantly higher.
Maternal dietary patterns during early pregnancy and birth weight in Japan

Taku Obara, Hiroyuki Suganuma, Mami Ishikuro, Takuma Usuzaki, Takahiro Yamashita, Fumihiko Ueno, Yudai Yonezawa, Shinichi Kuriyama, Aoi Noda, Keiko Murakami

European Journal of Public Health　29　2019/11/01
Publisher: Oxford University Press (OUP)
DOI： 10.1093/eurpub/ckz187.128 　

ISSN： 1101-1262

eISSN： 1464-360X

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<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The average birth weight in Japan has decreased by 200 g in the last 40 years. Only three studies were reported for the association between maternal dietary patterns and birth weight in East Asia, whose results were inconsistent. We examined what maternal dietary patterns were associated with the birth weight in Japan.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Totally 22,493 pregnant women were recruited between July 2013 and September 2016 into the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. We included 17,287 women who had a full-term single healthy baby into the analysis. Consumption of food and beverage items was evaluated based on food frequency questionnaire at the first-trimester. Dietary patterns were analyzed using a machine learning method of k-means clustering algorithm. Birth weight was obtained from the medical record. The association between dietary patterns and birth weight was analyzed using multiple liner regression model adjusted for potential confounders with multiple imputation method for missing values.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Dietary patterns were classified into seven groups by cluster analysis: “high in rice (reference) (n = 8046)”, “middle in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 4842)”, “high in fruits (n = 1176)”, “high in bread, dairy and alcohol (n = 1091)”, “high in meat and fish (n = 1049)”, “high in coffee, black tea, soft drinks and confections (high in coffee) (n = 585)”, and “high in vegetables, beans, mushrooms, seaweeds and miso-soup (n = 498)” groups. In multiple liner regression models, birth weight was 22.6 g (95%CI: 0.1 to 45.2 g) heavier in “high in fruits” group than in reference group and 39.4 g (95%CI: 8.6 to 70.3 g) lighter in “high in coffee” group than in reference group. The other groups were not statistically significant.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>High consumption of fruits and high consumption of coffee, black tea, soft drinks and confections during early pregnancy were associated with increased and decreased birth weight, respectively.</jats:p> </jats:sec> <jats:sec> <jats:title>Key messages</jats:title> <jats:p>We found maternal dietary patterns during early pregnancy using a machine learning method of k-means clustering algorithm. We found maternal dietary patterns which associated with the birth weight in Japan.</jats:p> </jats:sec>
Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children's Study. International-journal Peer-reviewed

Kaou Tanoue, Hidekazu Nishigori, Zen Watanabe, Kosuke Tanaka, Kasumi Sakurai, Satoshi Mizuno, Mami Ishikuro, Taku Obara, Masahito Tachibana, Tetsuro Hoshiai, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Journal of interpersonal violence　36　(21-22)　886260519881517-886260519881517　2019/10/16

DOI： 10.1177/0886260519881517 　

ISSN： 0886-2605

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This study aimed to clarify the interannual changes in intimate partner violence against pregnant women after the March 11, 2011 Great East Japan Earthquake in target areas of Miyagi Prefecture that were damaged by the earthquake and tsunami. Because of this disaster, in Miyagi Prefecture, approximately 12,000 people died or went missing, and approximately 238,000 buildings were destroyed. According to the U.S. Geological Survey, the Great East Japan Earthquake is the fourth largest earthquake in the world and the largest in Japan since 1900. The present study was part of the Japan Environment and Children's Study. Data from June 2011 to May 2014 of 79,222 pregnant women were analyzed, calculating the prevalence of physical and mental intimate partner violence in the inland, north coastal, and south coastal areas of Miyagi. These prevalence rates were compared with nationwide rates of intimate partner violence in 2011 using univariate and logistic regression analyses. After the disaster, the incidence of mental intimate partner violence increased in the south coastal area and then improved later (19.4%, 13.1%, and 13.3% for south coastal area, and 13.8%, 13.8%, and 13.1% for nationwide in 2011, 2012, and 2013, respectively). However, in the north coastal area, the incidence of physical intimate partner violence increased after the disaster and then improved later (2.7%, 1.5%, and 1.3% for north coastal area, and 1.4%, 1.3%, and 1.1% for nationwide in 2011, 2012, and 2013, respectively). In the inland area, however, the prevalence of both mental and physical intimate partner violence was consistently higher than nationwide rates after the disaster.
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
遺伝因子と飲酒量の交互作用と随時血圧値の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 清水厚志, 菅原準一, 栗山進一, 辻一郎, 木下賢吾, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　216-216　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
睡眠の測定機器から得られた睡眠状況と心理的苦痛との関連

五十嵐有香, 小暮真奈, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 宮川健, 宇留野晃, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討東北メディカル・メガバンク計画コホート調査の成果から

小暮真奈, 平田匠, 土屋菜歩, 中村智洋, 宮川健, 小清水宏, 小原拓, 目時弘仁, 宇留野晃, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10
Publisher: (NPO)日本高血圧学会
非喫煙者における受動喫煙の有無と家庭高血圧の関連

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10
Publisher: (NPO)日本高血圧学会
血漿メタボロームと頸動脈内膜中膜肥厚の関連

寳澤篤, 小柴生造, 平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 元池育子, 三枝大輔, 峯岸直子, 栗山進一, 田宮元, 辻一郎, 木下賢吾, 呉繁夫

日本高血圧学会総会プログラム・抄録集　42回　304-304　2019/10
Publisher: (NPO)日本高血圧学会
配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査 Peer-reviewed

中谷直樹, 土屋菜歩, 成田暁, 石黒真美, 目時弘仁, 平田匠, 小暮真奈, 中村智洋, 後岡広太郎, 中谷久美, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　78回　224-224　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク機構三世代コホート調査実施から開発された遺伝教育ツール Peer-reviewed

小林朋子, 山中千鶴, 永井雅人, 菊谷昌浩, 栗山進一

日本公衆衛生学会総会抄録集　78回　365-365　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
TMM計画地域住民コホート調査(宮城)調査票項目と総死亡の関連 Peer-reviewed

寳澤篤, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 中村智洋, 小原拓, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 布施昇男, 山本雅之

日本公衆衛生学会総会抄録集　78回　212-212　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
6.3万人データ分譲に向けて東北メディカル・メガバンク計画地域住民コホート調査 Peer-reviewed

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 村上慶子, 小原拓, 中谷直樹, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　78回　212-212　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高血圧有病率からみた尿ナトカリ比の目標値と必要測定回数の検討東北メディカル・メガバンク計画コホート調査の成果から Peer-reviewed

小暮真奈, 平田匠, 土屋菜歩, 中村智洋, 宮川健, 小清水宏, 小原拓, 目時弘仁, 宇留野晃, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　287-287　2019/10
Publisher: (NPO)日本高血圧学会
非喫煙者における受動喫煙の有無と家庭高血圧の関連 Peer-reviewed

平田匠, 小暮真奈, 成田暁, 佐藤倫広, 土屋菜歩, 中村智洋, 宇留野晃, 小原拓, 目時弘仁, 中谷直樹, 菅原準一, 栗山進一, 呉繁夫, 寳澤篤

日本高血圧学会総会プログラム・抄録集　42回　288-288　2019/10
Publisher: (NPO)日本高血圧学会
Psychological Characteristics of Children at Two Years after the Great East Japan Earthquake: Analyses of Telephone Consultation Records. Peer-reviewed

Sakama R, Yokokawa H, Fujibayashi K, Naito T, Sato Y, Yamanaka C, Kikuya M, Miyashita M, Kuriyama S

The Tohoku journal of experimental medicine　249　(2)　85-92　2019/10

DOI： 10.1620/tjem.249.85 　

ISSN： 0040-8727

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The 2011 Great East Japan Earthquake was the largest and most catastrophic earthquake and tsunami in Japanese history. The aim of the present study was to evaluate the burden and psychological characteristics of children at 2 years after this catastrophe to allow a better understanding of the situation and the provision of appropriate support. We investigated a cross-sectional study carried out in 2013 by sending a questionnaire to schools located in Miyagi Prefecture to be answered by parents or guardians. The questionnaire included the Strengths and Difficulties Questionnaire (SDQ) to estimate the psychological adaptation of children. Telephone consultations were provided for children with SDQ scores > 16 whose parents or guardians had given consent. From the target population of 12,742, a total of 4,074 responses were received (response rate: 32%), among which, 720 had an SDQ score > 16 and received a telephone consultation. At the time of the telephone consultation, 301 (42%) of the 720 children and parents or guardians showed some type of psychological reaction and were thus classified as "Insufficient recovery". Among these, 230 had not received social support at any point in time, suggesting the need for long-term psychological support. Those who resided in a coastal area tended to show a higher rate of psychological reactions than those in an inland area (27.1% vs. 12.9%, respectively). In conclusion, catastrophic disasters have a long-lasting psychological impact on children, and thus, long-term psychological support may be needed.
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. International-journal Peer-reviewed

Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Fuji Nagami, Naoko Minegishi, Soichi Ogishima, Takako Takai-Igarashi, Inaho Danjoh, Taku Obara, Mami Ishikuro, Tomoko Kobayashi, Yayoi Aizawa, Rino Ishihara, Masayuki Yamamoto, Yoichi Suzuki

BMC medical education　19　(1)　297-297　2019/08/02

DOI： 10.1186/s12909-019-1725-5 　

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BACKGROUND: Genome cohort studies are used to analyze interactions between genetic and environmental factors, providing valuable information for personalized healthcare. Large-scale and long-term cohort studies require a number of specially trained personnel, of whom those involved in obtaining informed consent play a vital role, especially during the initial phase of such studies. The Japanese Society of Human Genetics (JSHG) previously established a certification system for genome medical research coordinators (GMRCs) responsible for obtaining written consent via face-to-face explanation. Meanwhile, in the Tohoku Medical Megabank Organization (ToMMo), GMRCs are expected to play important roles not only in obtaining informed consent and conducting various assessments, but also in communicating with participants throughout the long-term follow-up. Based on the JSHG program, we therefore developed a specific education and training program for ToMMo GMRCs consisting of 17 lectures, one practical training session on the informed consent procedure, and written and interview examinations. Re-education workshops aimed at self-improvement are also carried out following certification. In this study, we evaluated the education and training program in terms of overall understanding, usefulness, and satisfaction using an anonymous questionnaire. METHODS: An anonymous questionnaire addressing each aspect of the education and training program (understanding, usefulness, and satisfaction) was distributed among 152 qualified ToMMo GMRCs. Responses were received from 94 participants (61.8%). RESULTS: There was a significant association between the level of overall understanding of lectures and medical qualification (nurse or clinical laboratory technologist), but not with age or educational background. The level of understanding and overall usefulness were lower in sessions related to genetics and epidemiology than those dealing with ToMMo practices. In the re-education workshops, GMRCs showed a preference for and hoped to learn more about both background knowledge and research progress in the ToMMo. CONCLUSIONS: The results of our questionnaire suggest that not all ToMMo GMRCs are able to understand everything during the initial education and training program, especially in terms of genomic medicine. Continuous re-education is therefore vital in improving knowledge, skills and motivation, and preparing GMRCs for a specialist role in community-based personalized healthcare.
三世代コホート調査参加児に対する発達評価方法の検討 Peer-reviewed

小林美佳, 小林朋子, 山中千鶴, 峯岸直子, 栗山進一, 呉繁夫

日本小児科学会雑誌　123　(8)　1330-1330　2019/08
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Outlier detection for questionnaire data in biobanks. Peer-reviewed

Sakurai R, Ueki M, Makino S, Hozawa A, Kuriyama S, Takai-Igarashi T, Kinoshita K, Yamamoto M, Tamiya G

International journal of epidemiology　48　(4)　1305-1315　2019/08
Publisher: Oxford University Press (OUP)
DOI： 10.1093/ije/dyz012 　

ISSN： 0300-5771

eISSN： 1464-3685

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<title>Abstract</title> <sec> <title>Background</title> Biobanks increasingly collect, process and store omics with more conventional epidemiologic information necessitating considerable effort in data cleaning. An efficient outlier detection method that reduces manual labour is highly desirable. </sec> <sec> <title>Method</title> We develop an unsupervised machine-learning method for outlier detection, namely kurPCA, that uses principal component analysis combined with kurtosis to ascertain the existence of outliers. In addition, we propose a novel regression adjustment approach to improve detection, namely the regression adjustment for data by systematic missing patterns (RAMP). </sec> <sec> <title>Result</title> Application to epidemiological record data in a large-scale biobank (Tohoku Medical Megabank Organization, Japan) shows that a combination of kurPCA and RAMP effectively detects known errors or inconsistent patterns. </sec> <sec> <title>Conclusions</title> We confirm through the results of the simulation and the application that our methods showed good performance. The proposed methods are useful for many practical analysis scenarios. </sec>
母子保健情報と学校保健情報の連係に基づく発育指標の関連

上野史彦, 小原拓, 村上慶子, 野田あおい, 大柳元, 石黒真美, 目時弘仁, 黒川修行, 栗山進一

東北公衆衛生学会誌　(68)　20-20　2019/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. International-journal Peer-reviewed

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Kasumi Sakurai, Tetsuro Hoshiai, Masatoshi Saito, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nariyasu Mano, Hirohito Metoki, Nobuo Yaegashi

Congenital anomalies　59　(4)　110-117　2019/07

DOI： 10.1111/cga.12293 　

ISSN： 0914-3505

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We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0.67%) also took in dietary folic acid at ≥480 μg/day. Multivariate logistic regression analyses demonstrated no association between preconception folic acid supplementation and NTDs in offspring or fetuses (odds ratio [OR] 0.622; 95% confidence interval [CI]: 0.226-1.713). Moreover, the participants who combined preconception folic acid supplement use with dietary folic acid intake ≥480 μg/day demonstrated no incidence of NTDs in offspring or fetuses. Our analysis is limited by the absence of the data on the daily amount of supplementary folic acid intake, requiring careful attention to the interpretation. Additional surveys are required in Japan to resolve those limitations for further comprehensive assessment.
Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake. Peer-reviewed

Kuniyoshi Y, Kikuya M, Matsubara H, Ishikuro M, Obara T, Kure S, Kuriyama S

Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine　14　(6)　382-389　2019/07
Publisher: Mary Ann Liebert Inc
DOI： 10.1089/bfm.2018.0254 　

ISSN： 1556-8253

eISSN： 1556-8342
Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, Keiko Miyakoda, Masato Suzuka, Yasuko Ikeda-Sakai, Manabu Akazawa, Nobukazu Nakasato, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　28　(6)　804-811　2019/06

DOI： 10.1002/pds.4749 　

ISSN： 1053-8569

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PURPOSE: To evaluate the prevalence and patterns of prescriptions of antiepileptic drugs (AEDs) to prenatal and postpartum women in Japan using a large administrative database. METHODS: The dates of pregnancy onset and delivery were estimated using published algorithms and infant birth months. The prevalence of prescribed AEDs, the maximum dose of some AEDs, and the frequency of potential combination therapy with AEDs were evaluated for the 180 days before pregnancy onset, during pregnancy, and at 180-day postpartum. RESULTS: In total, 33 941 pregnant women were eligible for analysis. At least one AED was prescribed to 225 women (66 per 10 000 deliveries) between 180 days before pregnancy and 180-day postpartum and for 135 women (40 per 10 000 deliveries) during pregnancy. The prevalence of AED prescription declined during the first and second trimesters and increased in the third trimester and postpartum. Valproate was the most frequently prescribed drug, followed by clonazepam, lamotrigine, and carbamazepine. Nine (18.4%) of the 49 women with at least one prescription record of valproate in the first trimester were prescribed more than 600 mg/day of valproate. Concerning potential combination therapy, 40 (12 per 10 000 deliveries) concurrently received two or more AEDs between 180 days before pregnancy and 180-day postpartum, respectively, 31 (9 per 10 000 deliveries) women received these drugs during pregnancy. CONCLUSIONS: Various AEDs were prescribed to pregnant Japanese women. Women of reproductive age should select the appropriate AED before becoming pregnant, depending on the risk benefit profile.
一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 宮崎真理子, 寳澤篤

日本腎臓学会誌　61　(3)　332-332　2019/05
Publisher: (一社)日本腎臓学会
ISSN： 0385-2385

eISSN： 1884-0728
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
自閉スペクトラム症研究東北メディカル・メガバンク計画における三世代コホート調査参加児に対する試み Peer-reviewed

小林朋子, 小林美佳, 山中千鶴, 栗山進一, 呉繁夫

脳と発達　51　(Suppl.)　S249-S249　2019/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
Respiratory resistance among adults in a population-based cohort study in Northern Japan. International-journal Peer-reviewed

Miura E, Tsuchiya N, Igarashi Y, Arakawa R, Nikkuni E, Tamai T, Tabata M, Ohkouchi S, Irokawa T, Ogawa H, Takai-Igarashi T, Suzuki Y, Kuriyama S, Tamiya G, Hozawa A, Yamamoto M, Kurosawa H

Respiratory investigation　57　(3)　274-281　2019/05

DOI： 10.1016/j.resinv.2018.12.008 　

ISSN： 2212-5345

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BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data. METHODS: We reviewed FOT data and relevant patient clinical and biological information collected from the Community-Based Cohort Study (CommCohort Study), carried out between 2013 to 2016 as a part of the Tohoku Medical Megabank project (TMM). In total, 16,231 adults were enrolled in the study (Male/Female: 4886/11,345). RESULTS: Significant gender differences were observed in distributions of Rrs and Xrs values at 5 Hz (termed R5 and X5, respectively). R5 values in males were lower than those in females, while X5 values in males were slightly less negative. High R5 values were strongly associated with high BMI, short height, smoking status in males, high serum IgE level, and high peripheral blood eosinophil count. CONCLUSION: The present distribution values and their relation to clinical and biological data should provide useful insights for clinical settings and serve as a helpful guide in implementing FOT. Forced oscillation technique, respiratory system resistance, respiratory system reactance, gender difference, obesity.
Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing Peer-reviewed

Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, Fumiki Katsuoka, Sakae Saito, Naoki Nariai, Akira Ono, Naomi Nakai-Inagaki, Kazuharu Misawa, Keiko Tateno, Yosuke Kawai, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Kichiya Suzuki, Kengo Kinoshita, Masao Nagasaki, Masayuki Yamamoto

The Pharmacogenomics Journal　19　(2)　136-146　2019/04/19
Publisher: Springer Nature
DOI： 10.1038/s41397-017-0010-4 　

ISSN： 1470-269X
東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

平田匠, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐藤衛, 菊谷昌浩, 石垣泰, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

糖尿病　62　(Suppl.1)　S-304　2019/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X

eISSN： 1881-588X
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. International-journal Peer-reviewed

Kosuke Tanaka, Hidekazu Nishigori, Zen Watanabe, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Hirotaka Hamada, Tetsuro Hoshiai, Masatoshi Saito, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Hypertension research : official journal of the Japanese Society of Hypertension　42　(4)　558-566　2019/04

DOI： 10.1038/s41440-019-0206-x 　

ISSN： 0916-9636

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Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the association of maternal smoking with the risk of hypertensive disorders of pregnancy (HDP) in a low-risk population-based cohort of 76,303 pregnant women. This study was a part of the Japan Environment and Children's Study. Smoking status was assessed using questionnaires completed by participants. Information about HDP was assessed using questionnaires completed by doctors. Compared with that for women who did not smoke, women who continued smoking >10 cigarettes per day during pregnancy had a significantly higher risk of developing HDP (odds ratio: 1.58, 95% confidence interval: 1.11-2.25). In multivariate analyses with adjustment for possible confounding factors, the association still remained (odds ratio: 1.51, 95% confidence interval: 1.04-2.19). When we regarded the number of cigarettes as a continuous variable, there was a linear association between the number of cigarettes and risk of HDP, with an odds ratio of 1.02 per cigarette per day (95% confidence interval: 1.00-1.04). Smoking a greater number of cigarettes was associated with a higher risk of HDP after adjustment for possible confounding factors. Cigarette smoking cessation may avoid the complications of HDP. Our findings suggest that, in addition to the risk of small-for-gestational-age children, an increased risk of HDP should be considered in the management of pregnant women who smoke cigarettes.
成人における客観的睡眠効率と高血圧有病率との関連(Association of Objective Sleep Efficiency with Prevalence of Hypertension in Adults) Peer-reviewed

平田匠, 中村智洋, 小暮真奈, 成田暁, 宮川健, 後岡広太郎, 土屋菜歩, 小原拓, 中谷直樹, 栗山進一, 寳澤篤

日本循環器学会学術集会抄録集　83回　OJ22-4　2019/03
Publisher: (一社)日本循環器学会
The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. International-journal Peer-reviewed

Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima

Reproductive biology and endocrinology : RB&E　17　(1)　27-27　2019/02/22

DOI： 10.1186/s12958-019-0471-1 　

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BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001-1.198; MZT: AOR 4.229, 95% CI 2.614-6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT.
Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. International-journal Peer-reviewed

Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauchi, Daisuke Saigusa, Maiko Wagata, Taku Obara, Mami Ishikuro, Yoshiki Tsunemoto, Yuki Harada, Tomoko Shibata, Takahiro Mimori, Junko Kawashima, Fumiki Katsuoka, Takako Igarashi-Takai, Soichi Ogishima, Hirohito Metoki, Hiroaki Hashizume, Nobuo Fuse, Naoko Minegishi, Seizo Koshiba, Osamu Tanabe, Shinichi Kuriyama, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Satoshi Hiyama, Masao Nagasaki

BMJ open　9　(2)　e025939　2019/02/19

DOI： 10.1136/bmjopen-2018-025939 　

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PURPOSE: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome. PARTICIPANTS: Pregnant women were recruited at the timing of first routine antenatal visits at Tohoku University Hospital, Sendai, Japan, between September 2015 and November 2016. Of the eligible women who were invited, 65.4% agreed to participate, and a total of 302 women were enrolled. The inclusion criteria were age ≥20 years and the ability to access the internet using a smartphone in the Japanese language. FINDINGS TO DATE: Study participants uploaded daily general health information including quality of sleep, condition of bowel movements and the presence of nausea, pain and uterine contractions. Participants also collected physiological data, such as body weight, blood pressure, heart rate and body temperature, using multiple home healthcare devices. The mean upload rate for each lifelog item was ranging from 67.4% (fetal movement) to 85.3% (physical activity), and the total number of data points was over 6 million. Biospecimens, including maternal plasma, serum, urine, saliva, dental plaque and cord blood, were collected for multiomics analysis. FUTURE PLANS: Lifelog and multiomics data will be used to construct a time-course high-resolution reference catalogue of pregnancy. The reference catalogue will allow us to discover relationships among multidimensional phenotypes and novel risk markers in pregnancy for the future personalised early prediction of pregnancy complications.
Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. International-journal Peer-reviewed

Zen Watanabe, Hidekazu Nishigori, Kaou Tanoue, Kosuke Tanaka, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Masatoshi Saito, Masahito Tachibana, Ikuma Fujiwara, Takahiro Arima, Takashi Takeda, Shinichi Kuriyama, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki

Journal of affective disorders　245　475-483　2019/02/15

DOI： 10.1016/j.jad.2018.11.061 　

ISSN： 0165-0327

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BACKGROUND: Dysmenorrhea influences emotional distress as well as physical suffering in young non-pregnant women. The aim of this study was to assess the potential association between preconception dysmenorrhea and the development of psychological distress during pregnancy. METHODS: This study was a part of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study conducted between 2011 and 2014 in Japan. A total of 87,102 pregnant Japanese women with no psychological distress (Kessler 6-item psychological distress scale [K6] score ≤ 12) in early pregnancy were eligible. Among these, 7626 had mild and 1638 had severe preconception dysmenorrhea. The prevalence and risk of maternal psychological distress (K6 scores ≥ 13) in the second or third trimester were compared among preconception dysmenorrhea severity groups. RESULTS: A higher percentage of women with mild (2.6%) or severe preconception dysmenorrhea (3.6%) suffered psychological distress during pregnancy compared to that in women without dysmenorrhea (2.1%). A multilevel logistic regression model, adjusting for baseline characteristics and the K6 score at enrollment, showed that the severity of dysmenorrhea was associated with psychological distress (mild dysmenorrhea: adjusted odds ratio [aOR], 1.154; 95% confidence interval [95% CI], 0.980-1.359; and severe dysmenorrhea: aOR, 1.457; 95% CI, 1.087-1.951). LIMITATIONS: Information about dysmenorrhea was obtained during early pregnancy. The JECS did not have clear diagnostic criteria for dysmenorrhea. CONCLUSIONS: Preconception dysmenorrhea is associated with an elevated incidence of psychological distress during pregnancy. Additionally, expectant mothers with a history of severe dysmenorrhea symptoms before pregnancy have a higher risk of developing psychological distress.
Paternal height has an impact on birth weight of their offspring in a Japanese population: The Japan Environment and Children’s Study Peer-reviewed

Takagi K, Iwama N, Metoki H, Uchikura Y, Matsubara Y, Matsubara K, Nishigori H, Saito M, Fujiwara I, Sakurai K, Kuriyama S, Arima T, Nakai K, Yaegashi N, Sugiyama T, Japan Environment, Children’s Study Group

Journal of Developmental Origins of Health and Disease　2019/02
Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. International-journal Peer-reviewed

Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto

Journal of biochemistry　165　(2)　139-158　2019/02/01

DOI： 10.1093/jb/mvy096 　

ISSN： 0021-924X

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Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms of medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, medical genetics and prospective cohort studies to develop a critical infrastructure for the establishment of PHC. To date, a TMM CommCohort (adult general population) and a TMM BirThree Cohort (birth+three-generation families) have conducted recruitments and baseline surveys. Genome analyses as part of the TMM Project will aid in the development of a high-fidelity whole-genome Japanese reference panel, in designing custom single-nucleotide polymorphism (SNP) arrays specific to Japanese, and in estimation of the biological significance of genetic variations through linked investigations of the cohorts. Whole-genome sequencing from >3,500 unrelated Japanese and establishment of a Japanese reference genome sequence from long-read data have been done. We next aim to obtain genotype data for all TMM cohort participants (>150,000) using our custom SNP arrays. These data will help identify disease-associated genomic signatures in the Japanese population, while genomic data from TMM BirThree Cohort participants will be used to improve the reference genome panel. Follow-up of the cohort participants will allow us to test the genetic markers and, consequently, contribute to the realization of PHC.
Significant Association of House Collapse With High Urine Na/K Ratios Among 24,580 Coastal Residents Who Survived the Great East Japan Earthquake Peer-reviewed

Mikami Takahiro, Tanno Kozo, Sasaki Ryohei, Takanashi Nobuyuki, Kotozaki Yuka, Hozawa Atsushi, Kogure Mana, Kuriyama Shinichi, Tsuji Ichiro, Sato Mamoru, Hitomi Jiro, Sakata Kiyomi, Sasaki Makoto

CIRCULATION　139　2019

DOI： 10.1161/circ.139.suppl_1.P086 　

ISSN： 0009-7322
Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. International-journal Peer-reviewed

Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Journal of hypertension　37　(1)　206-215　2019/01

DOI： 10.1097/HJH.0000000000001846 　

ISSN： 0263-6352

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OBJECTIVES: Although a twin pregnancy is a risk factor for hypertensive disorders of pregnancy, studies investigating longitudinal blood pressure changes during twin pregnancies are uncommon. The aims of this study were to evaluate the longitudinal blood pressure changes during twin pregnancies and to compare blood pressure levels between twin and singleton pregnancies. METHODS: Five hundred dichorionic diamniotic twin, 240 monochorionic diamniotic twin, and 80 775 singleton pregnancies were included in this Japanese prospective birth cohort study. A marginal model was applied to evaluate the SBP, DBP, and mean arterial pressure levels during early gestation, mid-gestation, and late gestation. RESULTS: The blood pressure levels fell from early-to-mid-gestation and rose after mid-gestation in the dichorionic and monochorionic diamniotic twin pregnancies. The SBP and mean arterial pressure levels during early gestation and the DBP and mean arterial pressure levels during late gestation were higher in the dichorionic diamniotic twin pregnancies than those in the singleton pregnancies. The blood pressure levels in the monochorionic diamniotic twin pregnancies were higher than those in the singleton pregnancies at each gestational stage, except for the SBP during late gestation. CONCLUSION: Although the longitudinal blood pressure changes during twin pregnancies were similar to those during singleton pregnancies, the blood pressure levels during twin pregnancies were higher. Further studies that examine the associations between the longitudinal blood pressure changes during pregnancy and the perinatal outcomes in twin pregnancies are necessary.
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. International-journal Peer-reviewed

Noriyuki Iwama, Hirohito Metoki, Hidekazu Nishigori, Satoshi Mizuno, Fumiaki Takahashi, Kosuke Tanaka, Zen Watanabe, Masatoshi Saito, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Takashi Sugiyama, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

Hypertension research : official journal of the Japanese Society of Hypertension　42　(1)　85-94　2019/01

DOI： 10.1038/s41440-018-0124-3 　

ISSN： 0916-9636

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This study examined the association between maternal alcohol consumption during pregnancy and hypertensive disorders of pregnancy in the Japan Environment and Children's Study, a nationwide birth cohort study. A total of 76 940 pregnant women were included in the analysis. Information about alcohol consumption during pregnancy was obtained using two questionnaires: T1 and T2. The mean (standard deviation) gestational age in the T1 and T2 questionnaires were 16.5 (5.8) and 27.9 (3.7) weeks, respectively. Alcohol consumption was considered as an exposure, hypertensive disorders of pregnancy as an outcome, and possible confounding factors were included in a generalized linear mixed-effects model with a logit link function. Among the study subjects, 2 348 (3.1%) women developed hypertensive disorders of pregnancy. Compared with 25 300 women who never drank alcohol, 43 women who drank alcohol according to the T1 questionnaire and continued to drink ≥150 g ethanol/week according to the T2 questionnaire had significantly higher odds of hypertensive disorders of pregnancy. The adjusted odds ratio was 3.98 (95% confidence interval [CI], 1.33-11.9). In conclusion, alcohol consumption of ≥150 g ethanol/week during pregnancy is better avoided because of the high odds of developing hypertensive disorders of pregnancy. It may be meaningful that healthcare providers confirm information about alcohol consumption during pregnancy. Moreover, discontinuation of alcohol consumption is recommended to prevent the onset of hypertensive disorders of pregnancy in Japan.
Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. International-journal Peer-reviewed

Masao Nagasaki, Yoko Kuroki, Tomoko F Shibata, Fumiki Katsuoka, Takahiro Mimori, Yosuke Kawai, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Yoichi Suzuki, Hiroshi Kawame, Fuji Nagami, Takako Takai-Igarashi, Soichi Ogishima, Kaname Kojima, Kazuharu Misawa, Osamu Tanabe, Nobuo Fuse, Hiroshi Tanaka, Nobuo Yaegashi, Kengo Kinoshita, Shiego Kure, Jun Yasuda, Masayuki Yamamoto

Human genome variation　6　27-27　2019

DOI： 10.1038/s41439-019-0057-7 　

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In recent genome analyses, population-specific reference panels have indicated important. However, reference panels based on short-read sequencing data do not sufficiently cover long insertions. Therefore, the nature of long insertions has not been well documented. Here, we assembled a Japanese genome using single-molecule real-time sequencing data and characterized insertions found in the assembled genome. We identified 3691 insertions ranging from 100 bps to ~10,000 bps in the assembled genome relative to the international reference sequence (GRCh38). To validate and characterize these insertions, we mapped short-reads from 1070 Japanese individuals and 728 individuals from eight other populations to insertions integrated into GRCh38. With this result, we constructed JRGv1 (Japanese Reference Genome version 1) by integrating the 903 verified insertions, totaling 1,086,173 bases, shared by at least two Japanese individuals into GRCh38. We also constructed decoyJRGv1 by concatenating 3559 verified insertions, totaling 2,536,870 bases, shared by at least two Japanese individuals or by six other assemblies. This assembly improved the alignment ratio by 0.4% on average. These results demonstrate the importance of refining the reference assembly and creating a population-specific reference genome. JRGv1 and decoyJRGv1 are available at the JRG website.
3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. International-journal Peer-reviewed

Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, Satoshi Makino, Sakae Saito, Akihito Otsuki, Chinatsu Gocho, Mika Sakurai-Yageta, Inaho Danjoh, Ikuko N Motoike, Yumi Yamaguchi-Kabata, Matsuyuki Shirota, Seizo Koshiba, Masao Nagasaki, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Atsushi Shimizu, Jun Yasuda, Nobuo Fuse, Gen Tamiya, Masayuki Yamamoto, Kengo Kinoshita

Human genome variation　6　28-28　2019

DOI： 10.1038/s41439-019-0059-5 　

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The first step towards realizing personalized healthcare is to catalog the genetic variations in a population. Since the dissemination of individual-level genomic information is strictly controlled, it will be useful to construct population-level allele frequency panels with easy-to-use interfaces. In the Tohoku Medical Megabank Project, we sequenced nearly 4000 individuals from a Japanese population and constructed an allele frequency panel of 3552 individuals after removing related samples. The panel is called the 3.5KJPNv2. It was constructed by using a standard pipeline including the 1KGP and gnomAD algorithms to reduce technical biases and to allow comparisons to other populations. Our database is the first large-scale panel providing the frequencies of variants present on the X chromosome and on the mitochondria in the Japanese population. All the data are available on our original database at https://jmorp.megabank.tohoku.ac.jp.
Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. International-journal Peer-reviewed

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

Pharmacoepidemiology and drug safety　27　(12)　1325-1334　2018/12

DOI： 10.1002/pds.4654 　

ISSN： 1053-8569

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PURPOSE: The purpose of the study is to evaluate the status of prescribed antihypertensives primarily during pregnancy, but also before pregnancy and after delivery, using a large claims database in Japan. METHODS: The dates of pregnancy onset and delivery were identified using reported algorithms and the birth months of infants. The prevalence and timing of prescribed antihypertensives during pregnancy were descriptively evaluated. Time trends in prescriptions were evaluated using multivariate logistic regression analyses. We also evaluated the prevalence of antihypertensives prescribed within 180 days before pregnancy and 180 days after delivery among women who were covered by health insurers during the entire period. RESULTS: At least one antihypertensive agent was prescribed for 1144 (2.74%) of 41 693 pregnant women. The most frequently prescribed oral antihypertensive during pregnancy was nifedipine, followed by methyldopa, hydralazine, and furosemide. Drugs targeting the renin-angiotensin system were prescribed for 21 pregnant women (0.05%), including angiotensin II receptor blockers that were prescribed for 19 (0.05%) of them. Nicardipine was the most frequently prescribed injectable antihypertensive during pregnancy, followed by furosemide, hydralazine, and nitroglycerin. Annual prescription trends remained similar except for a significant decrease in those for oral and injectable furosemide and an annual increase in those for organic nitrate. Based on an evaluation of 33 941 pregnant women, the number of prescriptions for antihypertensives increased particularly during the third trimester, then decreased from 91 to 180 days after delivery. CONCLUSIONS: Various types of antihypertensives are prescribed for Japanese pregnant women. The effects of exposing pregnant Japanese women to these agents should be evaluated.
Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. International-journal Peer-reviewed

Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, Chizuru Yamanaka, Satoshi Mizuno, Masahiro Kikuya, Hirohito Metoki, Hiroko Matsubara, Masato Nagai, Tomoko Kobayashi, Machiko Kamiyama, Mikako Watanabe, Kazuhiko Kakuta, Minami Ouchi, Aki Kurihara, Naru Fukuchi, Akihiro Yasuhara, Masumi Inagaki, Makiko Kaga, Shigeo Kure, Shinichi Kuriyama

Scientific reports　8　(1)　14840-14840　2018/10/04

DOI： 10.1038/s41598-018-33110-w 　

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We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. First, we focused on signs and biomarkers that have been identified as candidates for vitamin B6 responsiveness indicators. Second, we conducted hypothesis testing among these selected variables and their combinations. Finally, we further investigated the results by conducting cluster analyses with two different algorithms, affinity propagation and k-medoids. Statistically significant variables for vitamin B6 responsiveness, including combination of hypersensitivity to sound and clumsiness, and plasma glutamine level, were included. As an a priori variable, the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) scores was also included. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. To our knowledge, this is the first study to attempt to identify subgroup of persons with ASD who show specific treatment responsiveness using selected phenotype variables. We applied machine learning methods to further investigate these variables' ability to identify this subgroup of ASD, even when only a small sample size was available.
260. The Great East Japan Earthquake and hypertensive disorders of pregnancy: The TMM BirThree Cohort Study

Taku Obara, Takuma Usuzaki, Chizuru Yamanaka, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Masahiro Kikuya, Hirohito Metoki, Shinichi Kuriyama

Pregnancy Hypertension　13　S112-S113　2018/10/01
Publisher: Elsevier BV
DOI： 10.1016/j.preghy.2018.08.332 　

ISSN： 2210-7789

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Introduction We experienced a devastating disaster, the Great East Japan Earthquake, in 2011. Some previous studies showed that disasters affected maternal blood pressure and their health. Its longer effect on pregnant women is necessary to investigate. Objective The purpose of this present study was to investigate if maternal disaster exposure affected their blood pressure. Methods The relationship between disaster exposure and maternal outcomes was retrospectively analyzed using the data of 4426 women who were recruited to the Tohoku Medical Megabank Birth and Three-generation Cohort Study, which was conducted in the years 2013–2017. Women were classified into three groups by the severity of the destruction of their house: group A, no destruction/did not live in the disaster-hit area; group B, half/a part of the house was destroyed; and group C, house totally/mostly destroyed. Multiple logistic regression analysis was performed to investigate the relationship between disaster exposure and hypertensive disorders of pregnancy, adjusting for body mass index, age, smoking, drinking, income, parity, and multiple pregnancy. Results Of 4,426 women eligible for the analyses, the houses of 489 women (11.0%) were totally or mostly destroyed, and the houses of 1706 women (38.5%) were half or partly destroyed. Those whose houses were not destroyed or did not live in the area affected by the disaster included 2,231 women (50.4%). The prevalence of hypertensive disorders of pregnancy in groups B and C were 0.82 and 1.47 times higher than in group A, but there was no statistical significance. Discussion Involvement in a disaster event about three to six years before pregnancy was not related to a higher prevalence of hypertensive disorders of pregnancy.
Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. International-journal Peer-reviewed

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Atsushi Hozawa, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

Allergology international : official journal of the Japanese Society of Allergology　67　(4)　481-486　2018/10

DOI： 10.1016/j.alit.2018.02.009 　

ISSN： 1323-8930

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BACKGROUND: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires. METHODS: Of 46,648 invited children, we analyzed 9954 (21.3%) in the 2nd to the 8th grades from the ToMMo Child Health Study conducted in 2014 and 2015, a cross-sectional survey in Miyagi Prefecture, Japan. We defined eczema status as "normal," "mild/moderate," or "severe," based on the presence of persistent flexural eczema and sleep disturbance, according to the International Study of Asthma and Allergies in Childhood (ISAAC) Eczema Symptom Questionnaire. Clinical ranges of Strengths and Difficulties Questionnaire (SDQ) total difficulties scores and four SDQ subcategories of emotional symptoms, conduct problems, hyperactivity/inattention, and peer problems were defined as scores ≥16, ≥5, ≥5, ≥7, and ≥5, respectively. RESULTS: The mean SDQ total difficulties score significantly increased as eczema status worsened (all P ≤ 0.004 for trend). The OR of scores in the clinical range for SDQ total difficulties were 1.51 (95% CI, 1.31-1.74) for mild/moderate eczema and 2.63 (95% CI, 1.91-3.63) for severe eczema (P < 0.001 for trend), adjusted for sex, school grade, current wheeze, and disaster-related factors, using normal eczema as a reference. The association between severity of eczema and four SDQ subcategories showed a similar trend (all P ≤ 0.017 for trend). CONCLUSIONS: We found a significant association between severity of eczema and mental health problems. The presence of eczema was associated with four SDQ subcategories.
Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Peer-reviewed

Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, Yuki Sato, Satoshi Mizuno, Masako Miyashita, Masahiro Kikuya, Kasumi Sakurai, Atsushi Hozawa, Hiroaki Tomita, Yasuyuki Taki, Fuji Nagami, Hirohito Metoki, Shinichi Kuriyama

The Tohoku journal of experimental medicine　246　(2)　97-105　2018/10

DOI： 10.1620/tjem.246.97 　

ISSN： 0040-8727

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Involvement of family members, especially grandparents, in genome epidemiological research is important to investigate both genetic and environmental factors of common diseases. The aim of the present study was to establish strategies to obtain enough number of family recruitment, especially focusing on grandparents, for the Tohoku Medical Megabank Birth and Three-Generation Cohort Study. Our main strategies are summarized below. 1) We standardized informed consent process with reference materials to help people understand the consent form, 2) we created an invitation letter to contact family members, and 3) we recruited family members in several settings. To obtain informed consent, we were careful of explaining clearly the complex reasons as well as drawing people's attention. By the end of March 2017, the number of invitation letters distributed to family members through the pregnant women was 23,806, including 18,702 grandparents. Among the grandparents who received invitation letters, 2,935 (15.7%) responded to us. Furthermore, some grandparents were asked to provide informed consent with other family members by staff at maternal clinics or Community Support Centers, and others directly booked Community Support Centers without responding to the invitation letter. Grandparents joined the study anytime during mother's maternal check-ups or delivery. Overall, 8,054 grandparents participated in our birth cohort study. The setting in which most grandparents were recruited was our own facilities. Importantly, both paternal and maternal grandparents more frequently participated in the study if the father also participated. In conclusion, we are able to recruit not only pregnant women but also fathers and grandparents.
子どもコホート調査参加児の来所センターと住所との関連

小林朋子, 栗山進一

東北公衆衛生学会誌　(67)　32-32　2018/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
Early excessive growth with distinct seasonality in preschool obesity Peer-reviewed

Tsuyoshi Isojima, Noriko Kato, Susumu Yokoya, Atsushi Ono, Toshiaki Tanaka, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Shoichi Chida, Mitsuaki Hosoya, Shinichi Kuriyama, Shigeo Kure

Archives of Disease in Childhood　104　(1)　53-57　2018/06/05
Publisher: BMJ Publishing Group
DOI： 10.1136/archdischild-2018-314862 　

ISSN： 1468-2044 0003-9888
Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake Peer-reviewed

Nakaya Naoki, Nemoto Harumi, Yi Carine, Sato Ayako, Shingu Kotomi, Shoji Tomoka, Sato Shosuke, Tsuchiya Naho, Nakamura Tomohiro, Narita Akira, Kogure Mana, Sugawara Yumi, Yu Zhiqian, Gunawansa Nicole, Kuriyama Shinichi, Murao Osamu, Sato Takeshi, Imamura Fumihiko, Tsuji Ichiro, Hozawa Atsushi, Tomita Hiroaki

INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION　28　206-213　2018/06

DOI： 10.1016/j.ijdrr.2018.02.037 　

ISSN： 2212-4209
Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. International-journal Peer-reviewed

Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto

Genes to cells : devoted to molecular & cellular mechanisms　23　(6)　406-417　2018/06

DOI： 10.1111/gtc.12588 　

ISSN： 1356-9597

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Population-based prospective cohort studies are indispensable for modern medical research as they provide important knowledge on the influences of many kinds of genetic and environmental factors on the cause of disease. Although traditional cohort studies are mainly conducted using questionnaires and physical examinations, modern cohort studies incorporate omics and genomic approaches to obtain comprehensive physical information, including genetic information. Here, we report the design and midterm results of multi-omics analysis on population-based prospective cohort studies from the Tohoku Medical Megabank (TMM) Project. We have incorporated genomic and metabolomic studies in the TMM cohort study as both metabolome and genome analyses are suitable for high-throughput analysis of large-scale cohort samples. Moreover, an association study between the metabolome and genome show that metabolites are an important intermediate phenotype connecting genetic and lifestyle factors to physical and pathologic phenotypes. We apply our metabolome and genome analyses to large-scale cohort samples in the following studies.
Impact of the Great East Japan Earthquake on Body Mass Index, Weight, and Height of Infants and Toddlers: An Infant Survey. Peer-reviewed

Yokomichi H, Matsubara H, Ishikuro M, Kikuya M, Isojima T, Yokoya S, Kato N, Tanaka T, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S, Kure S, Yamagata Z

Journal of epidemiology　28　(5)　237-244　2018/05

DOI： 10.2188/jea.JE20170006 　

ISSN： 0917-5040

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BACKGROUND: The body mass index (BMI) of preschool children from 4 years of age through primary school has increased since the Great East Japan Earthquake, but that of children aged under 3 years has not been studied. This study evaluated how the anthropometrics of younger children changed following the earthquake. METHODS: Height and weight data of children living in northeast Japan were collected from 3-, 6-, 18-, and 42-month child health examinations. We compared the changes in BMI, weight, and height among infants affected by the earthquake between their 3- and 6-month health examinations, toddlers affected at 21-30 months of age (affected groups), and children who experienced the earthquake after their 42-month child health examination (unaffected group). A multilevel model was used to calculate the BMI at corresponding ages and to adjust for the actual age at the 3-month health examination, health examination interval, and gestational age. RESULTS: We recruited 8,479 boys and 8,218 girls living in Fukushima, Miyagi, and Iwate Prefectures. In the infants affected between their 3- and 6-month health examinations in Fukushima, the change in BMI at 42 months of age was greater than among the unaffected children. In the toddlers affected at 21-30 months of age in Fukushima, the change in BMI was greater, but changes in weight and height were less. CONCLUSIONS: Affected infants and toddlers in Fukushima suggested some growth disturbances and early adiposity rebound, which can cause obesity. The future growth of children affected by disasters should be followed carefully.
Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: The Kakegawa cohort study. International-journal Peer-reviewed

Hisashi Ohseto, Mami Ishikuro, Masahiro Kikuya, Taku Obara, Yuko Igarashi, Satomi Takahashi, Daisuke Kikuchi, Michiko Shigihara, Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Journal of psychosomatic research　107　20-25　2018/04

DOI： 10.1016/j.jpsychores.2018.01.013 　

ISSN： 0022-3999

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OBJECTIVE: Metabolic syndrome and the presence of metabolic syndrome components are risk factors for cardiovascular disease (CVD). However, the association between personality traits and metabolic syndrome remains controversial, and few studies have been conducted in East Asian populations. METHODS: We measured personality traits using the Japanese version of the Eysenck Personality Questionnaire (Revised Short Form) and five metabolic syndrome components-elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose-in 1322 participants aged 51.1±12.7years old from Kakegawa city, Japan. Metabolic syndrome score (MS score) was defined as the number of metabolic syndrome components present, and metabolic syndrome as having the MS score of 3 or higher. We performed multiple logistic regression analyses to examine the relationship between personality traits and metabolic syndrome components and multiple regression analyses to examine the relationship between personality traits and MS scores adjusted for age, sex, education, income, smoking status, alcohol use, and family history of CVD and diabetes mellitus. We also examine the relationship between personality traits and metabolic syndrome presence by multiple logistic regression analyses. RESULTS: "Extraversion" scores were higher in those with metabolic syndrome components (elevated waist circumference: P=0.001; elevated triglycerides: P=0.01; elevated blood pressure: P=0.004; elevated fasting glucose: P=0.002). "Extraversion" was associated with the MS score (coefficient=0.12, P=0.0003). No personality trait was significantly associated with the presence of metabolic syndrome. CONCLUSIONS: Higher "extraversion" scores were related to higher MS scores, but no personality trait was significantly associated with the presence of metabolic syndrome.
東北メディカル・メガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析(中間報告) Peer-reviewed

山田充啓, 杉浦久敏, 布施昇男, 寳澤篤, 高井貴子, 土屋奈歩, 光根歩, 栗山進一, 山本雅之, 一ノ瀬正和

日本呼吸器学会誌　7　(増刊)　213-213　2018/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876

eISSN： 2186-5884
The Association between Woman's Own Birth Weight and Her Subsequent Risk for Hypertensive Disorders of Pregnancy. Peer-reviewed

Wagata Maiko, Tsuchiya Naho, Nakaya Naoki, Ishikuro Mami, Metoki Hirohito, Hozawa Atsushi, Kuriyama Shinichi, Yaegashi Nobuo, Sugawara Junichi

REPRODUCTIVE SCIENCES　25　240A　2018/03

ISSN： 1933-7191
Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. International-journal Peer-reviewed

Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

Journal of human genetics　63　(2)　213-230　2018/02

DOI： 10.1038/s10038-017-0347-1 　

ISSN： 1434-5161

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Clarifying allele frequencies of disease-related genetic variants in a population is important in genomic medicine; however, such data is not yet available for the Japanese population. To estimate frequencies of actionable pathogenic variants in the Japanese population, we examined the reported pathological variants in genes recommended by the American College of Medical Genetics and Genomics (ACMG) in our reference panel of genomic variations, 2KJPN, which was created by whole-genome sequencing of 2049 individuals of the resident cohort of the Tohoku Medical Megabank Project. We searched for pathogenic variants in 2KJPN for 57 autosomal ACMG-recommended genes responsible for 26 diseases and then examined their frequencies. By referring to public databases of pathogenic variations, we identified 143 reported pathogenic variants in 2KJPN for the 57 ACMG recommended genes based on a classification system. At the individual level, 21% of the individuals were found to have at least one reported pathogenic allele. We then conducted a literature survey to review the variants and to check for evidence of pathogenicity. Our results suggest that a substantial number of people have reported pathogenic alleles for the ACMG genes, and reviewing variants is indispensable for constructing the information infrastructure of genomic medicine for the Japanese population.
Earlier BMI rebound and lower pre-rebound BMI as risk of obesity among Japanese preschool children. International-journal Peer-reviewed

Kato N, Isojima T, Yokoya S, Tanaka T, Ono A, Yokomichi H, Yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikuya M, Chida S, Hosoya M, Kuriyama S, Kure S

International journal of obesity (2005)　42　(1)　52-58　2018/01

DOI： 10.1038/ijo.2017.242 　

ISSN： 0307-0565

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OBJECTIVES: Longitudinal growth data of children were analyzed to clarify the relationship between the timing of body mass index (BMI) rebound and obesity risk in later ages. SUBJECTS/METHODS: Of 54 558 children born between April 2004 and March 2005 and longitudinally measured in April and October every year in the preschool period, 15 255 children were analyzed wherein no longitudinal measurement is missing after 1 year of age. BMI rebound age was determined as the age with smallest BMI value across longitudinal individual data after 1 year of age. Rebound age was compared between overweight and non-overweight groups. The subjects were divided into groups based on the timing of rebound. The sex- and age-adjusted mean of the BMI, height and weight s.d. scores for age group, along with 6 months weight and height gain, were compared among groups using analysis of covariance. RESULTS: Among those who were overweight at 66-71 months of age, BMI rebound age obtained at approximately 3 years of age was compared with the non-overweight group, whose BMI rebound age was utmost 66 months or later (P<0.001). The comparison among BMI age group showed that earlier BMI rebound results in larger BMI (P<0.001) and larger weight and height gain after the rebound (P<0.001). Among the group with BMI rebound earlier than 30 months of age, low BMI was observed (P<0.001). Slight elevation of height and weight gain was observed before the BMI rebound among groups with rebound age earlier than 60 months of age (P<0.001). CONCLUSION: Earlier BMI rebound timing with pre-rebound low BMI leads to greater childhood obesity risk; hence, early detection and prevention is necessary for such cases.
Effect of the Fukushima earthquake on weight in early childhood: a retrospective analysis. International-journal Peer-reviewed

Ono A, Isojima T, Yokoya S, Kato N, Tanaka T, Yamagata Z, Chida S, Matsubara H, Tanaka S, Ishikuro M, Kikuya M, Kuriyama S, Kure S, Hosoya M

BMJ paediatrics open　2　(1)　e000229　2018

DOI： 10.1136/bmjpo-2017-000229 　

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Objective: There have been no reports evaluating the physical growth in early childhood in Fukushima Prefecture after the Great East Japan Earthquake. We retrospectively investigated the health examination data in early childhood (aged 0-3 years). Methods: We divided the affected children into respective groups according to the interval from the disaster to the time of health examination and age as follows: group I, birth to 3-4 months in boys (1.81 (range, 0-6 months)) and girls (1.79 (range, 0-7 months)); group II, 3-4 months to 6-10 months in boys (6.37 (range, 3-9 months)) and girls (6.35 (range, 3-9 months)); group III, 6-10 months and 18 months in boys (16.2 (range, 5-22 months)) and girls (16.9 (range, 5-22 months)); and group IV, 18 months to 36-42 months in boys (21.0 (range, 18-24 months)) and girls (21.0 (range, 18-24 months)). Using height and body mass index, the health status of each group was compared with that of unaffected controls (ie, children who experienced the disaster after their health examination at 36-42 months). Results: The change in body mass index between the health examinations at 18 months and 36-42 months was significantly increased in group I (95% CI: all boys, 0.192 to 0.276 vs -0.006 to 0.062, P<0.001 and all girls, 0.108 to 0.184 vs -0.109 to -0.035, P<0.001) and group II (95% CI: all boys, 0.071 to 0.141 vs -0.006 to 0.062, P=0.002 and all girls, -0.042 to 0.024 vs -0.109 to -0.035, P=0.013). Conclusions: Children who were affected by the disaster in Fukushima Prefecture in early childhood were overweight. The use of pre-existing information, such as health examination data, was beneficial for investigating the physical growth of affected children.
Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis Peer-reviewed

Hiroshi Hidaka, Daiki Ozawa, Shinichi Kuriyama, Taku Obara, Toru Nakano, Risako Kakuta, Kazuhiro Nomura, Kenichi Watanabe, Yukio Katori

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY　274　(11)　3951-3958　2017/11

DOI： 10.1007/s00405-017-4716-3 　

ISSN： 0937-4477

eISSN： 1434-4726
Alterations in physique among young children after the Great East Japan Earthquake: Results from a nationwide survey Peer-reviewed

Masahiro Kikuya, Hiroko Matsubara, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

JOURNAL OF EPIDEMIOLOGY　27　(10)　462-468　2017/10

DOI： 10.1016/j.je.2016.09.012 　

ISSN： 0917-5040
東日本大震災後の住環境変化に伴う成人気管支喘息の有症率・有病率と真菌・ダニアレルゲン量に関する検討

押方智也子, 渡辺麻衣子, 石田雅嗣, 小林誠一, 山崎朗子, 鎌田洋一, 栗山進一, 矢内勝, 釣木澤尚実

Medical Mycology Journal　58　(Suppl.1)　74-74　2017/09
Publisher: (一社)日本医真菌学会
ISSN： 2185-6486

eISSN： 2186-165X
Prolonged elevated body mass index in preschool children after the Great East Japan Earthquake Peer-reviewed

Tsuyoshi Isojima, Susumu Yokoya, Atsushi Ono, Noriko Kato, Toshiaki Tanaka, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Shoichi Chida, Mitsuaki Hosoya, Shinichi Kuriyama, Shigeo Kure

PEDIATRICS INTERNATIONAL　59　(9)　1002-1009　2017/09

DOI： 10.1111/ped.13340 　

ISSN： 1328-8067

eISSN： 1442-200X
Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women Peer-reviewed

Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　313　(1)　1007-1013　2017/07

DOI： 10.3945/jn.109.109314 　

ISSN： 1040-0605

eISSN： 1522-1504
Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren Peer-reviewed

Miyashita M, Ishikuro M, Kikuya M, Yamanaka C, Mizuno S, Nagai M, Sato Y, Obara T, Metoki H, Kikuchi A, Nakaya N, Hozawa A, Tsuji I, Yaegashi N, Yamamoto M, Kure S, Kuriyama S

Journal of Pediatrics and Congenital Disorders　4　101　2017/07
Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design Peer-reviewed

Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura, Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka, Masayuki Yamamoto

BMC MEDICAL INFORMATICS AND DECISION MAKING　17　(1)　100　2017/07

DOI： 10.1186/s12911-017-0494-5 　

ISSN： 1472-6947
東日本大震災後の住環境の変化によるアレルギー疾患の有症率・有病率調査とダニアレルゲン・真菌の関与

押方智也子, 渡辺麻衣子, 石田雅嗣, 小林誠一, 鎌田洋一, 山崎朗子, 栗山進一, 矢内勝, 釣木澤尚実

日本職業・環境アレルギー学会雑誌　25　(1)　55-55　2017/06
Publisher: 日本職業・環境アレルギー学会
ISSN： 1349-5461
Pregnant Women's Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

Hidekazu Nishigori, Toshie Nishigori, Kasumi Sakurai, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Zen Watanabe, Noriyuki Iwama, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Shinichi Kuriyama, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Fumiaki Takahashi, Nobuo Yaegashi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(3)　355-364　2017/06

DOI： 10.1017/dmp.2016.150 　

ISSN： 1935-7893

eISSN： 1938-744X
Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study Peer-reviewed

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Satoshi Mizuno, Hirohito Metoki, Tetsuro Hoshiai, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi

CONGENITAL ANOMALIES　57　(3)　72-78　2017/05

DOI： 10.1111/cga.12202 　

ISSN： 0914-3505

eISSN： 1741-4520
Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. International-journal Peer-reviewed

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi

Pharmacy (Basel, Switzerland)　5　(2)　2017/04/10

DOI： 10.3390/pharmacy5020021 　

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Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.
Longitudinal changes in body mass index of children affected by the Great East Japan Earthquake. International-journal Peer-reviewed

Zheng W, Yokomichi H, Matsubara H, Ishikuro M, Kikuya M, Isojima T, Yokoya S, Tanaka T, Kato N, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S, Kure S, Yamagata Z

International journal of obesity (2005)　41　(4)　606-612　2017/04

DOI： 10.1038/ijo.2017.6 　

ISSN： 0307-0565

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BACKGROUND: The evacuation and disruption in housing caused by the 2011 Great East Japan Earthquake and following nuclear radiation may have influenced child health in many respects. However, studies regarding longitudinal childhood growth are limited. Therefore, in this study we aimed to explore the influence of the earthquake on longitudinal changes in body mass index in preschool children. METHODS: Participants were children from nursery schools who cooperated with the study in the Iwate, Miyagi and Fukushima prefectures. The exposed group consisted of children who experienced the earthquake during their preschool-age period (4-5 years old). The historical control group included children who were born 2 years earlier than the exposed children in the same prefectures. Trajectories regarding body mass index and prevalence of overweight/obesity were compared between the two groups using multilevel analysis. Differences in the changes in BMI between before and after the earthquake, and proportion of overweight/obesity was compared between the two groups. We also conducted subgroup analysis by defining children with specific personal disaster experiences within the exposed group. RESULTS: A total of 9722 children were included in the study. Children in the exposed group had higher body mass indices and a higher proportion of overweight after the earthquake than the control group. These differences were more obvious when confined to exposed children with specific personal disaster experiences. CONCLUSIONS: Children's growth and development-related health issues such as increased BMI after natural disasters should evoke great attention.
Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children's Study Peer-reviewed

Kasumi Sakurai, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Noriyuki Iwama, Zen Watanabe, Mami Ishikuro, Nozomi Tatsuta, Ichiko Nishijima, Junichi Sugawara, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Fumiaki Takahashi, Kunihiko Nakai, Nobuo Yaegashi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　11　(2)　216-226　2017/04

DOI： 10.1017/dmp.2016.109 　

ISSN： 1935-7893

eISSN： 1938-744X
The Association Between the History of Hypertensive Disorders of Pregnancy, Obesity and Hypertension in Later Life by Age Group: A Cross-Sectional Analysis. Peer-reviewed

Maiko Wagata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Hirohito Metoki, Akimune Fukushima, Nobuo Yaegashi, Shigeo Kure, Shinichi Kuriyama, Atsushi Hozawa, Junichi Sugawara

REPRODUCTIVE SCIENCES　24　63A-63A　2017/03

ISSN： 1933-7191

eISSN： 1933-7205
Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children's Study (JECS) Peer-reviewed

Taku Obara, Hidekazu Nishigori, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Nozomi Tatsuta, Satoshi Mizuno, Kasumi Sakurai, Ichiko Nishijima, Yuriko Murai, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE　30　(5)　588-593　2017/03

DOI： 10.1080/14767058.2016.1179273 　

ISSN： 1476-7058

eISSN： 1476-4954
Design of the health examination survey on early childhood physical growth in the Great East Japan Earthquake affected areas Peer-reviewed

Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Shoichi Chida, Mitsuaki Hosoya, Atsushi Ono, Noriko Kato, Susumu Yokoya, Toshiaki Tanaka, Tsuyoshi Isojima, Zentaro Yamagata, Soichiro Tanaka, Shinichi Kuriyama, Shigeo Kure

JOURNAL OF EPIDEMIOLOGY　27　(3)　135-142　2017/03

DOI： 10.1016/j.je.2016.03.001 　

ISSN： 0917-5040
Longitudinal changes in body mass index of children affected by the Great East Japan Earthquake International-journal Peer-reviewed

Zheng W, Yokomichi H, Matsubara H, Ishikuro M, Kikuya K, Isojima T, Yokoya S, Tanaka T, Kato N, Chida S, Ono A, Hosoya M, Tanaka S, Kuriyama S

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　41　(4)　606-612　2017/01/17

DOI： 10.1038/ijo.2017.6 　

ISSN： 0300-5771

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BACKGROUND: The evacuation and disruption in housing caused by the 2011 Great East Japan Earthquake and following nuclear radiation may have influenced child health in many respects. However, studies regarding longitudinal childhood growth are limited. Therefore, in this study we aimed to explore the influence of the earthquake on longitudinal changes in body mass index in preschool children. METHODS: Participants were children from nursery schools who cooperated with the study in the Iwate, Miyagi and Fukushima prefectures. The exposed group consisted of children who experienced the earthquake during their preschool-age period (4-5 years old). The historical control group included children who were born 2 years earlier than the exposed children in the same prefectures. Trajectories regarding body mass index and prevalence of overweight/obesity were compared between the two groups using multilevel analysis. Differences in the changes in BMI between before and after the earthquake, and proportion of overweight/obesity was compared between the two groups. We also conducted subgroup analysis by defining children with specific personal disaster experiences within the exposed group. RESULTS: A total of 9722 children were included in the study. Children in the exposed group had higher body mass indices and a higher proportion of overweight after the earthquake than the control group. These differences were more obvious when confined to exposed children with specific personal disaster experiences. CONCLUSIONS: Children's growth and development-related health issues such as increased BMI after natural disasters should evoke great attention.
Impact of the great east Japan earthquake on the body mass index of milk-fed infants and toddlers: a nationwide infant survey Peer-reviewed

Yokomichi H, Matsubara H, Ishikuro M, Kikuya M, Isojima G, Yokoya S, Kato N, Tanaka T, Ono A, Hosoya M, Chida S, Tanaka S, Kuriyama S, Kure S, Yamagata Z

International Journal of Pediatric Endocrinology　Suppl1　113-114　2017
Publisher: Springer Nature
DOI： 10.1186/s13633-017-0054-x 　
Growth seasonality during preschool childhood in nursery school children International-journal Peer-reviewed

Isojima G, Kato N, Yokoya S, Tanaka T, Ono A, Yokomichi H, Yamagata Z, Tanaka S, Matsubara H, Ishikuro M, Kikuya M, Chida S, Hosoya M, Kuriyama S, Kure S

International Journal of Pediatric Endocrinology　Suppl1　32-32　2017
Publisher: Springer Nature
DOI： 10.1186/s13633-017-0054-x 　
Disease prevalence among nursery school children after the Great East Japan earthquake. International-journal Peer-reviewed

Mami Ishikuro, Hiroko Matsubara, Masahiro Kikuya, Taku Obara, Yuki Sato, Hirohito Metoki, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Hiroshi Yokomichi, Zentaro Yamagata, Soichiro Tanaka, Shigeo Kure, Shinichi Kuriyama

BMJ global health　2　(2)　e000127　2017

DOI： 10.1136/bmjgh-2016-000127 　

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OBJECTIVE: To investigate the relationship between personal experience of the Great East Japan Earthquake and various disease types among nursery school children. DESIGN: We conducted a nationwide survey of nursery school children born between 2 April 2006 and 1 April 2007. Nursery school teachers completed questionnaires if they agreed to join the study. Questionnaire items for children consisted of their birth year and month, sex, any history of moving into or out of the current nursery school, presence of diseases diagnosed by a physician at the age of 66-78 months and type of disaster experience. The survey was conducted from September 2012 to December 2012. SETTING: Japan, nationwide. PARTICIPANTS: A total of 60 270 nursery school children were included in the analysis, 840 of whom experienced the disaster on 11 March 2011. MAIN OUTCOME MEASURES: The health status of children 1.5 years after the disaster based on nursery school records. RESULTS: Experiencing the disaster significantly affected the prevalence of overall and individual diseases. Furthermore, there was a difference in disease prevalence between boys and girls. In boys, experiencing the tsunami (OR 2.53, 95% CI 1.22 to 5.24) and living in an evacuation centre (OR 2.92, 95% CI 1.46 to 5.83) were remarkably associated with a higher prevalence of atopic dermatitis, but these trends were not observed among girls. Instead, the home being destroyed (OR 3.50, 95% CI 2.02 to 6.07) and moving house (OR 4.19, 95% CI 2.01 to 8.71) were positively associated with a higher prevalence of asthma among girls. CONCLUSIONS: Our study indicates that experiencing the disaster may have affected the health status of nursery school children at least up to 1.5 years after the disaster. Continuous monitoring of the health status of children is necessary to develop strategic plans for child health.
Randomized controlled trial of the effects of consumption of 'Yabukita' or 'Benifuuki' encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight. International-journal Peer-reviewed

Yuko Igarashi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, Michiko Shigihara, Hirohito Metoki, Masahiro Kikuya, Yoichi Sameshima, Hirofumi Tachibana, Mari Maeda-Yamamoto, Shinichi Kuriyama

Food & nutrition research　61　(1)　1334484-1334484　2017

DOI： 10.1080/16546628.2017.1334484 　

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Background: Previous studies have reported controversial results for the association between green tea consumption and low-density lipoprotein (LDL)-cholesterol and body weight. Objective: The objective of this trial was to determine the effects of two kinds of green tea on LDL-cholesterol and body weight. Methods: We randomly assigned 151 participants (98 men, 53 women) aged 30-70 years into three groups: Yabukita green tea group, Benifuuki green tea group, or placebo group. Participants consumed 1.8 g/day of green tea extract powder or placebo for 12 weeks. The primary outcomes were LDL-cholesterol level and body weight, and the secondary outcomes were risk factors for cardiovascular disease. Results: Both Yabukita and Benifuuki green tea significantly lowered LDL-cholesterol. The magnitudes of the lipid-lowering effect of both types of tea were significantly larger than that of placebo. No differences with respect to changes in LDL-cholesterol were observed between the Yabukita and Benifuuki green tea groups. Neither Yabukita nor Benifuuki green tea had any effect on body weight and no difference was observed among groups regarding changes in body weight. Conclusion: Both Yabukita and Benifuuki green tea lowered LDL-cholesterol, and the lipid-lowering effects of these two green teas were not different. Neither tea lowered body weight.
Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children's Study Peer-reviewed

Fumiaki Takahashi, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Taku Obara, Hirohito Metoki, Kasumi Sakurai, Mami Ishikuro, Noriyuki Iwama, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Takashi Sugiyama, Shinichi Kuriyama, Nobuo Yaegashi

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　240　(4)　309-321　2016/12

DOI： 10.1620/tjem.240.309 　

ISSN： 0040-8727

eISSN： 1349-3329
Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study Peer-reviewed

Satoshi Mizuno, Hidekazu Nishigori, Takashi Sugiyama, Fumiaki Takahashi, Noriyuki Iwama, Zen Watanabe, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Shinichi Kuriyama, Hirohito Metoki, Kunihiko Nakai, Hidekuni Inadera, Nobuo Yaegashi

DIABETES RESEARCH AND CLINICAL PRACTICE　120　132-141　2016/10

DOI： 10.1016/j.diabres.2016.07.020 　

ISSN： 0168-8227

eISSN： 1872-8227
The Tohoku Medical Megabank Project: Design and Mission Peer-reviewed

Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, Masayuki Yamamoto

JOURNAL OF EPIDEMIOLOGY　26　(9)　493-511　2016/09

DOI： 10.2188/jea.JE20150268 　

ISSN： 0917-5040
The structural origin of metabolic quantitative diversity Peer-reviewed

Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, Matsuyuki Shirota, Tomo Saito, Daisuke Saigusa, Inaho Danjoh, Fumiki Katsuoka, Soichi Ogishima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Miyuki Sakurai, Sachiko Hirano, Junichi Nakata, Hozumi Motohashi, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Yoichi Suzuki, Shigeo Kure, Nobuo Yaegashi, Osamu Tanabe, Kengo Kinoshita, Jun Yasuda, Masayuki Yamamoto

SCIENTIFIC REPORTS　6　31463　2016/08

DOI： 10.1038/srep31463 　

ISSN： 2045-2322
Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area Peer-reviewed

Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, Hirohito Metoki, Masahiro Kikuya, Naho Tsuchiya, Tomohiro Nakamura, Fuji Nagami, Shinichi Kuriyama, Atsushi Hozawa

PREHOSPITAL AND DISASTER MEDICINE　31　(3)　330-334　2016/06

DOI： 10.1017/S1049023X16000182 　

ISSN： 1049-023X

eISSN： 1945-1938
Adjunctive ultrasonography for breast cancer screening Reply Peer-reviewed

Noriaki Ohuchi, Akihiko Suzuki, Seiichiro Yamamoto, Shinichi Kuriyama, Takanori Ishida

LANCET　387　(10036)　2381-2382　2016/06

DOI： 10.1016/S0140-6736(16)30670-5 　

ISSN： 0140-6736

eISSN： 1474-547X
Knowledge, Attitude, and Practices Toward Blood Pressure Measurement at Home Among Japanese Nurses. International-journal Peer-reviewed

Ishikuro M, Ubeda SR, Obara T, Watanabe I, Metoki H, Kikuya M, Kuriyama S, Maruyama R, Ohkubo T, Imai Y

Home healthcare now　34　(4)　210-217　2016/04

DOI： 10.1097/NHH.0000000000000357 　

ISSN： 2374-4529

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The self-measurement of blood pressure (BP) at home is useful in predicting the level of target organ damage and in managing hypertension. Nurses are essential practitioners for managing hypertension; however, it is unclear whether they have adequate knowledge of home BP management. This study assessed the knowledge, attitudes, and practices of home BP measurement among Japanese nurses. A questionnaire regarding home BP measurement was distributed among nurses and collected by mail. A total of 6,002 (61.8%) responses were eligible for the study. The proportion of participants who correctly recognized the reference values for clinic BP and home BP was 9.9% and 2.8%. Midwives and those working for the government had the highest proportion of correct responses of reference values among all nursing subgroups. Participants who thought that home BP gave the most important BP information were 62.7%. About 60% of the participants who recommended home BP measurement to hypertensive patients preferred to recommend an upper-arm cuff device. Our findings suggested that more knowledge of home BP measurement among nurses is warranted.
Pregnant Women Had the Risk of Psychological Distress in Miyagi After the Great East Japan Earthquake: The Japan Environment and Children's Study (JECS). Peer-reviewed

Zen Watanabe, Hirohito Metoki, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Nobuo Yaegashi

REPRODUCTIVE SCIENCES　23　186A-186A　2016/03

ISSN： 1933-7191

eISSN： 1933-7205
Design of the Nationwide Nursery School Survey on Child Health Throughout the Great East Japan Earthquake Peer-reviewed

Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Shoichi Chida, Mitsuaki Hosoya, Atsushi Ono, Noriko Kato, Susumu Yokoya, Toshiaki Tanaka, Tsuyoshi Isojima, Zentaro Yamagata, Soichiro Tanaka, Shinichi Kuriyama, Shigeo Kure

JOURNAL OF EPIDEMIOLOGY　26　(2)　98-104　2016/02

DOI： 10.2188/jea.JE20150073 　

ISSN： 0917-5040

eISSN： 1349-9092
Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial Peer-reviewed

Ohuchi N, Suzuki A, Sobue T, Kawai M, Yamamoto S, Zheng YF, Shiono YN, Saito H, Kuriyama S, Tohno E, Endo T, Fukao A, Tsuji I, Yamaguchi T, Ohashi Y, Fukuda M, Ishida T, J-START investigator groups

LANCET　387　(10016)　341-348　2016/01/23

DOI： 10.1016/S0140-6736(15)00774-6 　

ISSN： 0140-6736

eISSN： 1474-547X
Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study Peer-reviewed

Zen Watanabe, Noriyuki Iwama, Hidekazu Nishigori, Toshie Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Kunihiko Nakai, Takahiro Arima, Takashi Takeda, Junichi Sugawara, Shinichi Kuriyama, Hirohito Metoki, Nobuo Yaegashi

JOURNAL OF AFFECTIVE DISORDERS　190　341-348　2016/01

DOI： 10.1016/j.jad.2015.10.024 　

ISSN： 0165-0327

eISSN： 1573-2517
Impact of the great east Japan earthquake on the body mass index of preschool children: a nationwide nursery school survey Peer-reviewed

Hiroshi Yokomichi, Wei Zheng, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Tsuyoshi Isojima, Susumu Yokoya, Toshiaki Tanaka, Noriko Kato, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Soichiro Tanaka, Shinichi Kuriyama, Shigeo Kure, Zentaro Yamagata

BMJ OPEN　6　(4)　e010978　2016

DOI： 10.1136/bmjopen-2015-010978 　

ISSN： 2044-6055
Whole-genome Japanese Reference Panel and future directions Peer-reviewed

Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, Nariai Naoki, Kojima Kaname, Kawai Yosuke, Yamaguchi-Kabata Yumi, Yokozawa Junji, Danjoh Inaho, Saito Sakae, Sato Yukuto, Mimori Takahiro, Tsuda Kaoru, Saito Rumiko, Pan Xiaoqing, Nishikawa Satoshi, Ito Shin, Kuroki Yoko, Tanabe Osamu, Fuse Nobuo, Kuriyama Shinichi, Kiyomoto Hideyasu, Hozawa Atsushi, Minegishi Naoko, Kinoshita Kengo, Kure Shigeo, Yaegashi Nobuo, Yamamoto Masayuki

GENES & GENETIC SYSTEMS　90　(6)　377　2015/12

ISSN： 1341-7568
Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study Peer-reviewed

Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, Taku Obara, Yuki Sato, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　237　(4)　297-305　2015/12

DOI： 10.1620/tjem.237.297 　

ISSN： 0040-8727

eISSN： 1349-3329
Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. International-journal Peer-reviewed

Ishikuro M, Obara T, Metoki H, Ohkubo T, Iwama N, Katagiri M, Nishigori H, Narikawa Y, Yagihashi K, Kikuya M, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y

Hypertension research : official journal of the Japanese Society of Hypertension　38　(11)　770-775　2015/11

DOI： 10.1038/hr.2015.97 　

ISSN： 0916-9636
Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. International-journal Peer-reviewed

Iwama N, Metoki H, Ohkubo T, Ishikuro M, Obara T, Kikuya M, Yagihashi K, Nishigori H, Sugiyama T, Sugawara J, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y, BOSHI Study Group

Hypertension research : official journal of the Japanese Society of Hypertension　39　(3)　151-7　2015/10

DOI： 10.1038/hr.2015.108 　

ISSN： 0916-9636

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This prospective cohort study compared measurements of maternal home blood pressure (HBP) with clinic blood pressure (CBP) before 20 weeks' gestation to determine associations with the risk of delivering a lower birth weight infant. A total of 605 Japanese women were included. Exposures were initial CBP, made between 10 weeks 0 days and 19 weeks 0 days, and HBP for comparison made within 1 week of CBP. Outcome was infant's birth weight, categorized and ranked as follows: ⩾3500 g, 3000-3499 g, 2500-2999 g and <2500 g. The proportional odds model with possible confounding factors was applied to compare the associations between CBP and HBP on infant birth weight. When both CBP and HBP were included simultaneously, the adjusted odds ratios (ORs) per 1 standard deviation (1s.d.) increase in clinic and home diastolic BP (DBP) were 1.06 (95% confidence interval (CI): 0.87-1.30) and 1.28 (95% CI: 1.04-1.58), respectively. The adjusted ORs per 1s.d. increase in clinic and home mean arterial pressure (MAP) were 1.02 (95% CI: 0.83-1.24) and 1.29 (95% CI: 1.04-1.59), respectively. Systolic BP measurement was not associated with infant birth weight. In conclusion, high maternal home DBP and MAP before 20 weeks' gestation was associated with a higher risk of lower infant birth weight than clinic DBP and MAP. Therefore, in addition to CBP, it may be worth having pregnant women measure HBP to determine the risk of lower infant birth weight.
Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals Peer-reviewed

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto

NATURE COMMUNICATIONS　6　8018　2015/08

DOI： 10.1038/ncomms9018 　

ISSN： 2041-1723
Differences between clinic and home blood pressure measurements during pregnancy. International-journal Peer-reviewed

Ishikuro M, Obara T, Metoki H, Ohkubo T, Kikuya M, Yaegashi N, Kuriyama S, Imai Y

Journal of hypertension　33　(7)　1492-1493　2015/07

DOI： 10.1097/HJH.0000000000000608 　

ISSN： 0263-6352
Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan Peer-reviewed

Hidekazu Nishigori, Michiho Sasaki, Taku Obara, Toshie Nishigori, Mami Ishikuro, Hirohito Metoki, Junichi Sugawara, Shinichi Kuriyama, Akira Hosoyachi, Nobuo Yaegashi, Takashi Kobayashi, Noboru Yoshizumi

DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS　9　(3)　307-312　2015/06

DOI： 10.1017/dmp.2015.51 　

ISSN： 1935-7893

eISSN： 1938-744X
Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake Peer-reviewed

Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, Yuki Sato, Taku Obara, Hirohito Metoki, Naoki Nakaya, Fuji Nagami, Hiroaki Tomita, Hideyasu Kiyomoto, Junichi Sugawara, Atsushi Hozawa, Nobuo Fuse, Yoichi Suzuki, Ichiro Tsuji, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Shinichi Kuriyama

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　236　(2)　123-130　2015/06

DOI： 10.1620/tjem.236.123 　

ISSN： 0040-8727

eISSN： 1349-3329
Change in and long-term investigation of neuro-otologic disorders in disaster-stricken Fukushima prefecture: retrospective cohort study before and after the Great East Japan Earthquake. International-journal Peer-reviewed

Hasegawa J, Hidaka H, Kuriyama S, Obara T, Hashimoto K, Tateda Y, Okumura Y, Kobayashi T, Katori Y

PloS one　10　(4)　e0122631　2015

DOI： 10.1371/journal.pone.0122631 　

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On March 11, 2011, Japan's northeast Pacific coast was hit by a gigantic earthquake and subsequent tsunami. Soma City in Fukushima Prefecture is situated approximately 44 km north of Fukushima Daiichi Nuclear Power Plant. Soma General Hospital is the only hospital in Soma City that provides full-time otolaryngological medical care. We investigated the changes in new patients from one year before to three years after the disaster. We investigated 18,167 new patients treated at our department during the four years from April 1, 2010 to March 31, 2014. Of the new patients, we categorized the diagnoses into Meniere's disease, acute low-tone sensorineural hearing loss, vertigo, sudden deafness, tinnitus, and facial palsy as neuro-otologic symptoms. We also investigated the changes in the numbers of patients whom we examined at that time concerning other otolaryngological disorders, including epistaxis, infectious diseases of the laryngopharynx, and allergic rhinitis. The total number of new patients did not change remarkably on a year-to-year basis. Conversely, cases of vertigo, Meniere's disease, and acute low-tone sensorineural hearing loss increased in number immediately after the disaster, reaching a plateau in the second year and slightly decreasing in the third year. Specifically, 4.8% of patients suffering from these neuro-otologic diseases had complications from depression and other mental diseases. With regard to new patients in our department, there was no apparent increase in the number of patients suffering from diseases other than neuro-otologic diseases, including epistaxis, and allergic rhinitis. Patients suffering from vertigo and/or dizziness increased during the first few years after the disaster. These results are attributed to the continuing stress and tension of the inhabitants. This investigation of those living in the disaster area highlights the need for long-term support.
Participants’ understanding of a randomized controlled trial (RCT) through informed consent procedures in the RCT for breast cancer screening, J-START International-journal Peer-reviewed

Narikawa Shiono Y, Zheng YF, Kikuya M, Kawai M, Ishida T, Kuriyama S, Ohuchi N

Trials　15　(1)　375-375　2014/09/25

DOI： 10.1186/1745-6215-15-375 　

ISSN： 1745-6215
Consumption of fruits, vegetables, and seaweeds (sea vegetables) and pancreatic cancer risk: The Ohsaki Cohort Study Peer-reviewed

Michiko Shigihara, Taku Obara, Masato Nagai, Yumi Sugawara, Takashi Watanabe, Masako Kakizaki, Yoshikazu Nishino, Shinichi Kuriyama, Ichiro Tsuji

CANCER EPIDEMIOLOGY　38　(2)　129-136　2014/04

DOI： 10.1016/j.canep.2014.01.001 　

ISSN： 1877-7821

eISSN： 1877-783X
Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis Peer-reviewed

Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen, K. Asayama, T. Ohkubo, M. Kikuya, R. Inoue, M. Satoh, M. Hosaka, M. T. Utsugi, T. Hirose, A. Hara, N. Fukushima, T. Obara, H. Metoki, Y. Imai, J. Johansson, A. Reunanen, A. Jula, K. Ohmori-Matsuda, S. Kuriyama, M. Kakizaki, A. Hozawa, I. Tsuji, T. Mountokalakis, A. Kollias, G. Thomopoulou, P. Kalogeropoulos, I. Skeva, E. Nasothimiou, N. Pantazis, N. Baibas, J. Boggia, E. Sandoya, J. A. Staessen, L. Thijs, N. Cauwenberghs, Z. Zhang, F. Wei, J. Knez, A. Odili, Y. Gu, Y. Liu, Y. Jin, L. Jacobs, T. Kuznetzova

PLoS Medicine　11　(1)　e1001591　2014/01/01

DOI： 10.1371/journal.pmed.1001591 　

ISSN： 1549-1676 1549-1277
Logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body Peer-reviewed

Hiroshi Hidaka, Taku Obara, Shinichi Kuriyama, Shin Kurosawa, Yukio Katori, Toshimitsu Kobayashi

International Journal of Pediatric Otorhinolaryngology　77　(10)　1677-1682　2013/10

DOI： 10.1016/j.ijporl.2013.07.024 　

ISSN： 0165-5876 1872-8464
Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya project. Peer-reviewed

Hozawa A, Sugawara Y, Tomata Y, Kakizaki M, Tsuboya T, Ohmori-Matsuda K, Nakaya N, Kuriyama S, Fukao A, Tsuji I

The journals of gerontology. Series A, Biological sciences and medical sciences　68　465-472　2013/04
Publisher: 4
DOI： 10.1093/gerona/gls198 　

ISSN： 1079-5006
Long sleep duration and cause-specific mortality according to physical function and self-rated health: the Ohsaki Cohort Study Peer-reviewed

Masako Kakizaki, Shinichi Kuriyama, Naoki Nakaya, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Shin Fukudo, Ichiro Tsuji

JOURNAL OF SLEEP RESEARCH　22　(2)　209-216　2013/04

DOI： 10.1111/j.1365-2869.2012.01053.x 　

ISSN： 0962-1105
Impact of Weight Change Since Age 20 and Cardiovascular Disease Mortality Risk - The Ohsaki Cohort Study Peer-reviewed

Wan-Ting Chou, Masako Kakizaki, Yasutake Tomata, Masato Nagai, Yumi Sugawara, Shinichi Kuriyama, Ichiro Tsuji

CIRCULATION JOURNAL　77　(3)　679-686　2013/03

DOI： 10.1253/circj.CJ-12-0745 　

ISSN： 1346-9843
Lactation pattern and the risk for hormone-related female cancer in Japan: the Ohsaki Cohort Study Peer-reviewed

Yumi Sugawara, Masako Kakizaki, Masato Nagai, Yasutake Tomata, Rena Hoshi, Ikue Watanabe, Yoshikazu Nishino, Shinichi Kuriyama, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER PREVENTION　22　(2)　187-192　2013/03

DOI： 10.1097/CEJ.0b013e3283564610 　

ISSN： 0959-8278
Green Tea (Cv: Benifuuki) Powder and Catechins Availability Peer-reviewed

Mari Maeda-Yamamoto, Hirofumi Tachibana, Yoichi Sameshima, Shinichi Kuriyama

Tea in Health and Disease Prevention　115-125　2013
Publisher: Elsevier Inc.
DOI： 10.1016/B978-0-12-384937-3.00010-0 　
土-11-O20-10 小児の広汎性発達障害患者における処方推移 : レセプトデータに基づく検討(精神科領域2,一般演題(口頭)20,再興、再考、創ろう最高の医療の未来) Peer-reviewed

佐藤倫広, 栗山進一, 小原拓, 大場延浩, 森川和彦, 石黒真美, 目時弘仁, 西郡秀和, 菊谷昌浩, 眞野成康

日本医療薬学会年会講演要旨集　23　(0)　225-225　2013
Publisher: 一般社団法人日本医療薬学会
DOI： 10.20825/amjsphcs.23.0_225_5 　
Associations Between Visit-to-visit Variability in Blood Pressure Measured in the Office and Antihypertensive Drugs: The J-HOME-Morning Study Peer-reviewed

Taku Obara, Masahiro Kikuya, Yuka Kobayashi, Kazuki Ishikura, Urara Ikeda, Mami Ishikuro, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　35　(4)　285-290　2013

DOI： 10.3109/10641963.2013.780070 　

ISSN： 1064-1963
Change of the Management of Treated Hypertensive Patients with or without Diabetes in Japan Peer-reviewed

Taku Obara, Takayoshi Ohkubo, Kazuki Ishikura, Taku Shibamiya, Urara Ikeda, Hirohito Metoki, Masahiro Kikuya, Nariyasu Mano, Shinichi Kuriyama, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　35　(2)　79-86　2013

DOI： 10.3109/10641963.2012.732640 　

ISSN： 1064-1963

eISSN： 1525-6006
Blood Pressure Measured in the Clinic and at Home During Pregnancy Among Nulliparous and Multiparous Women: The BOSHI Study Peer-reviewed

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Mami Yamamoto, Konomi Akutsu, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Katsuyo Yagihashi, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

AMERICAN JOURNAL OF HYPERTENSION　26　(1)　141-148　2013/01

DOI： 10.1093/ajh/hps002 　

ISSN： 0895-7061
Compliance to the recommendations on blood pressure measurements in the clinical settings Peer-reviewed

Taku Obara, Takayoshi Ohkubo, Nariyasu Mano, Shinichi Kuriyama, Yutaka Imai

JOURNAL OF HYPERTENSION　31　(1)　213-213　2013/01

DOI： 10.1097/HJH.0b013e32835aaffd 　

ISSN： 0263-6352
A tomato-rich diet is related to depressive symptoms among an elderly population aged 70 years and over: A population-based, cross-sectional analysis Peer-reviewed

Kaijun Niu, Hui Guo, Masako Kakizaki, Yufei Cui, Kaori Ohmori-Matsuda, Lei Guan, Atsushi Hozawa, Shinichi Kuriyama, Toru Tsuboya, Takashi Ohrui, Katsutoshi Furukawa, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

JOURNAL OF AFFECTIVE DISORDERS　144　(1-2)　165-170　2013/01

DOI： 10.1016/j.jad.2012.04.040 　

ISSN： 0165-0327
Nationwide Epidemiological Survey of Autoimmune Pancreatitis in Japan Peer-reviewed

Atsushi Kanno, Isao Nishimori, Atsushi Masamune, Kazuhiro Kikuta, Morihisa Hirota, Shinichi Kuriyama, Ichiro Tsuji, Tooru Shimosegawa

PANCREAS　41　(6)　835-839　2012/08

DOI： 10.1097/MPA.0b013e3182480c99 　

ISSN： 0885-3177

eISSN： 1536-4828
The predictive power of physical function assessed by questionnaire and physical performance measures for subsequent disability Peer-reviewed

Masayuki Hoshi, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Kaijun Niu, Kazuki Fujita, Shouzoh Ueki, Hiroshi Haga, Ryoichi Nagatomi, Ichiro Tsuji

Aging Clinical and Experimental Research　24　(4)　345-353　2012/08

DOI： 10.3275/8104 　

ISSN： 1594-0667 1720-8319

eISSN： 1720-8319
Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan: findings from a nationwide epidemiological survey. International-journal Peer-reviewed

Yu Abe, Yoko Aoki, Shinichi Kuriyama, Hiroshi Kawame, Nobuhiko Okamoto, Kenji Kurosawa, Hirofumi Ohashi, Seiji Mizuno, Tsutomu Ogata, Shigeo Kure, Tetsuya Niihori, Yoichi Matsubara

American journal of medical genetics. Part A　158A　(5)　1083-94　2012/05

DOI： 10.1002/ajmg.a.35292 　

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Costello syndrome and cardio-facio-cutaneous (CFC) syndrome are congenital anomaly syndromes characterized by a distinctive facial appearance, heart defects, and intellectual disability. Germline mutations in HRAS cause Costello syndrome, and mutations in KRAS, BRAF, and MAP2K1/2 (MEK1/2) cause CFC syndrome. Since the discovery of the causative genes, approximately 150 new patients with each syndrome have been reported. However, the clinico-epidemiological features of these disorders remain to be identified. In order to assess the prevalence, natural history, prognosis, and tumor incidence associated with these diseases, we conducted a nationwide prevalence study of patients with Costello and CFC syndromes in Japan. Based on the result of our survey, we estimated a total number of patients with either Costello syndrome or CFC syndrome in Japan of 99 (95% confidence interval, 77-120) and 157 (95% confidence interval, 86-229), respectively. The prevalences of Costello and CFC syndromes are estimated to be 1 in 1,290,000 and 1 in 810,000 individuals, respectively. An evaluation of 15 adult patients 18-32 years of age revealed that 12 had moderate to severe intellectual disability and most live at home without constant medical care. These results suggested that the number of adult patients is likely underestimated and our results represent a minimum prevalence. This is the first epidemiological study of Costello syndrome and CFC syndrome. Identifying patients older than 32 years of age and following up on the patients reported here is important to estimate the precise prevalence and the natural history of these disorders.
Blood pressure changes during pregnancy Peer-reviewed

Mami Ishikuro, Taku Obara, Hirohito Metoki, Takayoshi Ohkubo, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

HYPERTENSION RESEARCH　35　(5)　563-564　2012/05

DOI： 10.1038/hr.2012.33 　

ISSN： 0916-9636
Relationship Between Serum Adiponectin Levels and Disability-Free Survival Among Community-Dwelling Elderly Individuals: The Tsurugaya Project Peer-reviewed

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　67　(5)　530-536　2012/05

DOI： 10.1093/gerona/glr191 　

ISSN： 1079-5006
C-reactive protein (CRP) is a predictor of high medical-care expenditures in a community-based elderly population aged 70 years and over: The Tsurugaya project Peer-reviewed

Kaijun Niu, Atsushi Hozawa, Hui Guo, Kaori Ohmori-Matsuda, Yufei Cui, Satoru Ebihara, Naoki Nakaya, Shinichi Kuriyama, Toru Tsuboya, Masako Kakizaki, Takashi Ohrui, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

ARCHIVES OF GERONTOLOGY AND GERIATRICS　54　(3)　E392-E397　2012/05

DOI： 10.1016/j.archger.2012.01.014 　

ISSN： 0167-4943
妊娠と医薬品使用に関する問い合わせ内容の調査 Peer-reviewed

小原拓, 尾崎, 芙実, 吉中, 千佳, 前川, 麻央, 草場, 美津江, 石黒, 真美, 飯田, 優太郎, 鈴木, 文子, 松浦, 正樹, 佐賀, 利英, 佐藤, 真由美, 久道, 周彦, 島田, 美樹, 栗山, 栗山進一, 八重樫, 伸生, 眞野成康

医薬品相互作用研究　35　(3)　129-133　2012/04
Publisher:
ISSN： 0385-5015
Gamma-Glutamyltransferase and Cancer Incidence: The Ohsaki Cohort Study Peer-reviewed

Toru Tsuboya, Shinichi Kuriyama, Masato Nagai, Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Yoshikazu Nishino, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　22　(2)　144-150　2012/03

DOI： 10.2188/jea.JE20110071 　

ISSN： 0917-5040
The sixth nationwide epidemiological survey of chronic pancreatitis in Japan Peer-reviewed

Morihisa Hirota, Tooru Shimosegawa, Atsushi Masamune, Kazuhiro Kikuta, Kiyoshi Kume, Shin Hamada, Yasuyuki Kihara, Akihiko Satoh, Kenji Kimura, Ichiro Tsuji, Shinichi Kuriyama

PANCREATOLOGY　12　(2)　79-84　2012/03

DOI： 10.1016/j.pan.2012.02.005 　

ISSN： 1424-3903
Green tea consumption and the risk of incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 Study Peer-reviewed

Yasutake Tomata, Masako Kakizaki, Naoki Nakaya, Toru Tsuboya, Toshimasa Sone, Shinichi Kuriyama, Atsushi Hozawa, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　95　(3)　732-739　2012/03

DOI： 10.3945/ajcn.111.023200 　

ISSN： 0002-9165
Coffee Consumption and Mortality Risk Peer-reviewed

Kemmyo Sugiyama, Shinichi Kuriyama, Ichiro Tsuji

Coffee: Emerging Health Effects and Disease Prevention　211-226　2012/02/06
Publisher: Wiley-Blackwell
DOI： 10.1002/9781119949893.ch11 　
[Perceived stress and cardiovascular disease mortality. The Ohsaki Cohort Study]. Peer-reviewed

Emi Kowata, Atsushi Hozawa, Masako Kakizaki, Yasutake Tomata, Masato Nagai, Yumi Sugawara, Shinichi Kuriyama, Ichiro Tsuji

[Nihon koshu eisei zasshi] Japanese journal of public health　59　(2)　82-91　2012/02

DOI： 10.11236/jph.59.2_82 　

ISSN： 0546-1766

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OBJECTIVES: Previous studies have indicated that stress can affect the circulatory system. Although prospective studies have examined the association between perceived stress and cardiovascular disease (CVD) mortality, the results are still controversial. The purpose of the present study was to elucidate the relationship with stratified analyses by alcohol intake category and smoking status. METHODS: The prospective Ohsaki Cohort Study covered all National Health Insurance beneficiaries aged 40 to 79 years living in the precinct of Ohsaki Public Health Center, Miyagi, Japan. A total of 45,293 Japanese (21,552 men and 23,741 women), without a history of cancer, ischemic heart disease or stroke, and who answered all items related to stress level at the baseline in 1994, were followed prospectively. Over 12 years of follow-up, 1,751 deaths from CVD occurred (994 men and 757 women). We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) for CVD mortality according to the perceived stress categories. The low stress category was used as the reference in all analyses. RESULTS: Perceived stress demonstrated a significant positive association with CVD mortality for men; the multivariate adjusted HR for high versus low stress was 1.43 (95% CI: 1.19, 1.87, P = 0.006). No significant relationship was noted for women. With current smokers, perceived high stress versus low had a pronounced association for both men (HR = 1.76, 95% CI: 1.28, 2.41, P = 0.001) and women (HR = 1.61, 95% CI: 1.20, 2.16, P = 0.004), and a similar tendency was noted for current drinking (HR = 1.56, 95% CI: 1.16, 2.09, P = 0.006, HR = 1.42, 95% CI: 1.08, 1.87, P = 0.001). Additionally, for both smoking and drinking men, those reporting high stress had 2 times the risk of CVD mortality of their low stress counterparts (P for trend < 0.001). The interaction of perceived stress with smoking for CVD mortality was of borderline statistical significance only for men (P for interaction = 0.04). CONCLUSION: The results suggest that the percentage of current smoking and drinking are factors that distinguish between sexes with regard to the effects of perceived stress on the incidence of CVD mortality. Furthermore our present findings indicate that smoking and drinking habit are not the way to relieve one's stress. A review of these should be conducted and we need to enhance support for stress management as well as control over smoking and drinking habits.
自覚ストレスと循環器疾患死亡との関連大崎国保コホート研究 Peer-reviewed

木幡映美, 寳澤, 篤柿崎, 真沙子, 遠又, 靖丈, 永井, 雅人, 菅原, 由美, 栗山進一, 進一辻一郎

日本公衆衛生雑誌　59　(2)　82-91　2012/02
Publisher:
DOI： 10.11236/jph.59.2_82 　

ISSN： 0546-1766

eISSN： 2187-8986
Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people Peer-reviewed

Satoru Ebihara, Kaijun Niu, Takae Ebihara, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori-Matsuda, Naoki Nakaya, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, Ichiro Tsuji

FRONTIERS IN PHYSIOLOGY　3　238-238　2012

DOI： 10.3389/fphys.2012.00238 　

ISSN： 1664-042X
Impact of obesity, overweight and underweight on life expectancy and lifetime medical expenditures: the Ohsaki Cohort Study Peer-reviewed

Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Atsushi Hozawa, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji

BMJ OPEN　2　(3)　2012

DOI： 10.1136/bmjopen-2012-000940 　

ISSN： 2044-6055
Associations Between Day-by-Day Variability in Blood Pressure Measured at Home and Antihypertensive Drugs: The J-HOME-Morning Study Peer-reviewed

Kazuki Ishikura, Taku Obara, Tetsuo Kato, Masahiro Kikuya, Taku Shibamiya, Takahiro Shinki, Urara Ikeda, Yuka Kobayashi, Hirohito Metoki, Nariyasu Mano, Shinichi Kuriyama, Takayoshi Ohkubo, Yutaka Imai

CLINICAL AND EXPERIMENTAL HYPERTENSION　34　(4)　297-304　2012

DOI： 10.3109/10641963.2012.681087 　

ISSN： 1064-1963
PIHと脳血管障害をめぐる諸問題 24時間自由行動下血圧・家庭血圧と脳血管障害 Peer-reviewed

目時弘仁, 大久保, 孝義, 小原, 拓, 阿久津, 好美, 山本, 真実, 石黒, 真美, 櫻井, 香澄, 岩間, 憲之, 片桐, 未希子, 菊谷, 昌浩, 八木橋, 香津代, 森滋, 鈴木, 雅洲, 栗山, 栗山進一, 八重樫, 伸生, 今井潤

日本妊娠高血圧学会雑誌　19　49-53　2012/01
[Evidence based on epidemiological studies]. Peer-reviewed

Kuriyama, Shinichi

Nihon Rinsho　69 Suppl 8　575-580　2011/10
Subtypes of Resistant Hypertension Based on Out-of-Office Blood Pressure Measurement Peer-reviewed

Taku Obara, Takayoshi Ohkubo, Nariyasu Mano, Nobuo Yaegashi, Shinichi Kuriyama, Yutaka Imai

HYPERTENSION　58　(4)　E28-E28　2011/10

DOI： 10.1161/HYPERTENSIONAHA.111.178996 　

ISSN： 0194-911X
Body Mass Index and Diabetes in Asia: A Cross-Sectional Pooled Analysis of 900,000 Individuals in the Asia Cohort Consortium Peer-reviewed

Paolo Boffetta, Dale McLerran, Yu Chen, Manami Inoue, Rashmi Sinha, Jiang He, Prakash Chandra Gupta, Shoichiro Tsugane, Fujiko Irie, Akiko Tamakoshi, Yu-Tang Gao, Xiao-Ou Shu, Renwei Wang, Ichiro Tsuji, Shinichi Kuriyama, Keitaro Matsuo, Hiroshi Satoh, Chien-Jen Chen, Jian-Min Yuan, Keun-Young Yoo, Habibul Ahsan, Wen-Harn Pan, Dongfeng Gu, Mangesh Suryakant Pednekar, Shizuka Sasazuki, Toshimi Sairenchi, Gong Yang, Yong-Bing Xiang, Masato Nagai, Hideo Tanaka, Yoshikazu Nishino, San-Lin You, Woon-Puay Koh, Sue K. Park, Chen-Yang Shen, Mark Thornquist, Daehee Kang, Betsy Rolland, Ziding Feng, Wei Zheng, John D. Potter

PLOS ONE　6　(6)　e19930-e19930　2011/06

DOI： 10.1371/journal.pone.0019930 　

ISSN： 1932-6203
自閉症におけるビタミンB6反応性を予測する徴候・バイオマーカーの解明

栗山進一, 大内美南, 稲垣真澄, 角田和彦, 栗原亞紀, 安原昭博, 渡辺瑞香子, 上山真知子, 福地成, 加我牧子

脳と発達　43　(Suppl.)　S183-S183　2011/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
Nationwide Epidemiological Survey of Acute Pancreatitis in Japan Peer-reviewed

Kennichi Satoh, Tooru Shimosegawa, Atsushi Masamune, Morihisa Hirota, Kazuhiro Kikuta, Yasuyuki Kihara, Shinichi Kuriyama, Ichiro Tsuji, Akihiko Satoh, Shin Hamada

PANCREAS　40　(4)　503-507　2011/05

DOI： 10.1097/MPA.0b013e318214812b 　

ISSN： 0885-3177

eISSN： 1536-4828
Impact of physical activity and performance on medical care costs among the Japanese elderly Peer-reviewed

Guang Yang, Kaijun Niu, Kazuki Fujita, Atsushi Hozawa, Kaori Ohmori-Matsuda, Shinichi Kuriyama, Naoki Nakaya, Satoru Ebihara, Tatsuma Okazaki, Hiu Guo, Chihaya Miura, Hideko Takahashi, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

GERIATRICS & GERONTOLOGY INTERNATIONAL　11　(2)　157-165　2011/04

DOI： 10.1111/j.1447-0594.2010.00651.x 　

ISSN： 1444-1586
Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study Peer-reviewed

Mari Maeda-Yamamoto, Kaori Ema, Yoshiko Tokuda, Manami Monobe, Hirofumi Tachibana, Yoichi Sameshima, Shinichi Kuriyama

CYTOTECHNOLOGY　63　(2)　171-179　2011/03

DOI： 10.1007/s10616-010-9331-8 　

ISSN： 0920-9069

eISSN： 1573-0778
Risk factors for overactive bladder in the elderly population: A community-based study with face-to-face interview Peer-reviewed

Yoshihiro Ikeda, Haruo Nakagawa, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yayoi Masamune, Yoshikazu Nishino, Shinichi Kuriyama, Tetsutaro Ohnuma, Ichiro Tsuji, Yoichi Arai

INTERNATIONAL JOURNAL OF UROLOGY　18　(3)　212-218　2011/03

DOI： 10.1111/j.1442-2042.2010.02696.x 　

ISSN： 0919-8172
がん検診受診率モニタリングのための新しい調査票

渋谷大助, 栗山進一, 島田剛延, 加藤勝章, 菊地亮介, 猪股芳文

日本がん検診・診断学会誌　18　(3)　246-256　2011/02
Publisher:
ISSN： 1881-8846
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians Peer-reviewed

Wei Zheng, Dale F. McLerran, Betsy Rolland, Xianglan Zhang, Manami Inoue, Keitaro Matsuo, Jiang He, Prakash Chandra Gupta, Kunnambath Ramadas, Shoichiro Tsugane, Fujiko Irie, Akiko Tamakoshi, Yu-Tang Gao, Renwei Wang, Xiao-Ou Shu, Ichiro Tsuji, Shinichi Kuriyama, Hideo Tanaka, Hiroshi Satoh, Chien-Jen Chen, Jian-Min Yuan, Keun-Young Yoo, Habibul Ahsan, Wen-Harn Pan, Dongfeng Gu, Mangesh Suryakant Pednekar, Catherine Sauvaget, Shizuka Sasazuki, Toshimi Sairenchi, Gong Yang, Yong-Bing Xiang, Masato Nagai, Takeshi Suzuki, Yoshikazu Nishino, San-Lin You, Woon-Puay Koh, Sue K. Park, Yu Chen, Chen-Yang Shen, Mark Thornquist, Ziding Feng, Daehee Kang, Paolo Boffetta, John D. Potter

NEW ENGLAND JOURNAL OF MEDICINE　364　(8)　719-729　2011/02

DOI： 10.1056/NEJMoa1010679 　

ISSN： 0028-4793
Reliability and validity of the Western Ontario Shoulder Instability Index (WOSI) in the Japanese population Peer-reviewed

Taku Hatta, Nobuhisa Shinozaki, Rei Omi, Hirotaka Sano, Nobuyuki Yamamoto, Akira Ando, Hiroyuki Sugaya, Toshitake Aizawa, Shinichi Kuriyama, Eiji Itoi

Journal of Orthopaedic Science　16　(6)　732-736　2011
Publisher: Springer Tokyo
DOI： 10.1007/s00776-011-0141-4 　

ISSN： 1436-2023 0949-2658
Precipitating factors in the pathogenesis of peritonsillar abscess and bacteriological significance of the Streptococcus milleri group Peer-reviewed

Hidaka H, Kuriyama S, Yano H, Tsuji I, Kobayashi T

European Journal of Clinical Microbiology and Infectious Diseases　30　(4)　527-532　2011

DOI： 10.1007/s10096-010-1114-9 　
Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors Peer-reviewed

Toshimasa Sone, Shinichi Kuriyama, Naoki Nakaya, Atsushi Hozawa, Taichi Shimazu, Kozue Nomura, Shouzo Rikimaru, Ichiro Tsuji

FOOD & NUTRITION RESEARCH　55　2011

DOI： 10.3402/fnr.v55i0.8326 　

ISSN： 1654-6628

eISSN： 1654-661X
Seasonal Variation in Home Blood Pressure Measurements and Relation to Outside Temperature in Japan Peer-reviewed

Atsushi Hozawa, Shinichi Kuriyama, Taichi Shimazu, Kaori Ohmori-Matsuda, Ichiro Tsuji

CLINICAL AND EXPERIMENTAL HYPERTENSION　33　(3)　153-158　2011

DOI： 10.3109/10641963.2010.531841 　

ISSN： 1064-1963
1年間の要介護認定発生に対する基本チェックリストの予測妥当性の検証大崎コホート2006研究

遠又靖丈, 寳澤篤, 大森芳, 松田, 永井雅人, 菅原由美, 新田明美, 栗山進一, 辻一郎

日本公衆衛生雑誌　58　(1)　3-13　2011/01
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.58.1_3 　

ISSN： 0546-1766

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Objective The "Kihon Checklist" (a frailty checklist), consisting of 25 items, is used for screening frail elderly, based on the Japanese long-term care insurance system. However, few reports have investigated predictive ability of incident long-term care insurance certification in the Kihon Checklist. The purpose of this study was to investigate inter-relationships and accuracy as a screening test of individual items and criteria in the Kihon Checklist for incident long-term care insurance certification. Methods In December 2006, we distributed a questionnaire including the Kihon Checklist to individuals older than 65 years living in Ohsaki City, Japan. Among the valid respondents, we followed those who gave informed consent to follow-up, had more than 1 item of response on the Kihon Checklist, and were not qualified for long-term care insurance certification at the baseline. We further excluded individuals who died or moved away in the one year follow-up, analyzing 14,636 elderly. The age- and sex-adjusted odds ratio (OR) and 95% confidence interval (95%CI) for newly incident long-term care insurance certification were estimated by logistic regression analysis. Independent variables were each of the items and criteria in the Kihon Checklist used for screening of "frail elderly". In addition, we estimated the sensitivity and specificity, and conducted receiver operating characteristic (ROC) analysis for each criteria domain. Results 5,560 (38.0%) matched the criteria of "frail elderly". During the one year of follow-up, 483 (3.3%) required newly incident long-term care insurance certification. All of the items in the Kihon Checklist were significantly associated with incident long-term care insurance certification (range of ORs: 1.45–4.67). In addition, all of the criteria also significantly predicted the risk of incident long-term care insurance certification (range of OR: 1.93–6.54). The OR (95%CI) for "frail elderly" was 3.80 (3.02–4.78). Among the various domains, "20 items other than five related to prevention and support for depression" had the largest area under the ROC curve. Conclusion All items and criteria used for screening frail elderly in the Kihon Checklist are useful for predicting the risk of incident long-term care insurance certification during a one-year period. However, the strength of the relation and accuracy for screening test were variable among items or domains, and criteria values could be improved.
[Validation of the Kihon Checklist for predicting the risk of 1-year incident long-term care insurance certification: the Ohsaki Cohort 2006 Study]. Peer-reviewed

Yasutake Tomata, Atsushi Hozawa, Kaori Ohmori-Matsuda, Masato Nagai, Yumi Sugawara, Akemi Nitta, Shinichi Kuriyama, Ichiro Tsuji

[Nihon koshu eisei zasshi] Japanese journal of public health　58　(1)　3-13　2011/01

DOI： 10.11236/jph.58.1_3 　

ISSN： 0546-1766

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OBJECTIVE: The "Kihon Checklist" (a frailty checklist), consisting of 25 items, is used for screening frail elderly, based on the Japanese long-term care insurance system. However, few reports have investigated predictive ability of incident long-term care insurance certification in the Kihon Checklist. The purpose of this study was to investigate inter-relationships and accuracy as a screening test of individual items and criteria in the Kihon Checklist for incident long-term care insurance certification. METHODS: In December 2006, we distributed a questionnaire including the Kihon Checklist to individuals older than 65 years living in Ohsaki City, Japan. Among the valid respondents, we followed those who gave informed consent to follow-up, had more than 1 item of response on the Kihon Checklist, and were not qualified for long-term care insurance certification at the baseline. We further excluded individuals who died or moved away in the one year follow-up, analyzing 14,636 elderly. The age- and sex-adjusted odds ratio (OR) and 95% confidence interval (95%CI) for newly incident long-term care insurance certification were estimated by logistic regression analysis. Independent variables were each of the items and criteria in the Kihon Checklist used for screening of "frail elderly". In addition, we estimated the sensitivity and specificity, and conducted receiver operating characteristic (ROC) analysis for each criteria domain. RESULTS: 5,560 (38.0%) matched the criteria of "frail elderly". During the one year of follow-up, 483 (3.3%) required newly incident long-term care insurance certification. All of the items in the Kihon Checklist were significantly associated with incident long-term care insurance certification (range of ORs: 1.45-4.67). In addition, all of the criteria also significantly predicted the risk of incident long-term care insurance certification (range of OR: 1.93-6.54). The OR (95%CI) for "frail elderly" was 3.80 (3.02-4.78). Among the various domains, "20 items other than five related to prevention and support for depression" had the largest area under the ROC curve. CONCLUSION: All items and criteria used for screening frail elderly in the Kihon Checklist are useful for predicting the risk of incident long-term care insurance certification during a one-year period. However, the strength of the relation and accuracy for screening test were variable among items or domains, and criteria values could be improved.
History of cholelithiasis and the risk of prostate cancer: the Ohsaki Cohort Study Peer-reviewed

Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Hong Yan, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

INTERNATIONAL JOURNAL OF CANCER　128　(1)　185-191　2011/01

DOI： 10.1002/ijc.25303 　

ISSN： 0020-7136
Impact of walking on life expectancy and lifetime medical expenditure: the Ohsaki Cohort Study Peer-reviewed

Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Atsushi Hozawa, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji

BMJ OPEN　1　(2)　e000240-e000240　2011

DOI： 10.1136/bmjopen-2011-000240 　

ISSN： 2044-6055
RELATIONSHIPS BETWEEN N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE AND INCIDENT DISABILITY AND MORTALITY IN OLDER COMMUNITY-DWELLING ADULTS: THE TSURUGAYA STUDY Peer-reviewed

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　58　(12)　2439-2441　2010/12

DOI： 10.1111/j.1532-5415.2010.03190.x 　

ISSN： 0002-8614
Participation in health check-ups and mortality using propensity score matched cohort analyses Peer-reviewed

Atsushi Hozawa, Shinichi Kuriyama, Ikue Watanabe, Masako Kakizaki, Kaori Ohmori-Matsuda, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Qiang Li, Takayoshi Ohkubo, Yoshitaka Murakami, Ichiro Tsuji

PREVENTIVE MEDICINE　51　(5)　397-402　2010/11

DOI： 10.1016/j.ypmed.2010.08.017 　

ISSN： 0091-7435
Impact of Nocturia on Bone Fracture and Mortality in Older Individuals: A Japanese Longitudinal Cohort Study Peer-reviewed

Haruo Nakagawa, Kaijun Niu, Atsushi Hozawa, Yoshihiro Ikeda, Yasuhiro Kaiho, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Satoru Ebihara, Ryoichi Nagatomi, Ichiro Tsuji, Yoichi Arai

JOURNAL OF UROLOGY　184　(4)　1413-1418　2010/10

DOI： 10.1016/j.juro.2010.05.093 　

ISSN： 0022-5347
緑茶摂取と要介護認定・死亡リスクに関する研究大崎コホート2006研究 Peer-reviewed

遠又靖丈, 寳澤篤, 大森芳, 永井雅人, 菅原由美, 星玲奈, 曽根稔雅, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　69回　367-367　2010/10
Citrus consumption and cancer incidence: the Ohsaki cohort study Peer-reviewed

Wen-Qing Li, Shinichi Kuriyama, Qiang Li, Masato Nagai, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

INTERNATIONAL JOURNAL OF CANCER　127　(8)　1913-1922　2010/10

DOI： 10.1002/ijc.25203 　

ISSN： 0020-7136
Effect of Age on the Association between Body Mass Index and All-Cause Mortality: The Ohsaki Cohort Study Peer-reviewed

Masato Nagai, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Yumi Sugawara, Toshimasa Sone, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　20　(5)　398-407　2010/09

DOI： 10.2188/jea.JE20090204 　

ISSN： 0917-5040
【嗜好品と高血圧・循環器病】緑茶と高血圧・循環器病 Peer-reviewed

寳澤篤, 栗山進一

血圧　17　(8)　688-691　2010/08
History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study Peer-reviewed

Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Hong Yan, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

CANCER CAUSES & CONTROL　21　(7)　1025-1032　2010/07

DOI： 10.1007/s10552-010-9530-9 　

ISSN： 0957-5243
[Depression and the risk of long-term care insurance certification: the Tsurugaya project]. Peer-reviewed

Ohmori-Matsuda Kaori, Hozawa Atsushi, Sone Toshimasa, Koizumi-Masamune Yayoi, Nakaya Naoki, Kuriyama Shinichi, Suzuki Syuji, Awata Shuichi, Tsuji Ichiro

Nippon Koshu Eisei Zasshi　57　(7)　538-549　2010/07
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.57.7_538 　

ISSN： 0546-1766

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Objective The purpose of this study was to examine the relationship between depressive status and subsequent certification of long-term care insurance use, and to investigate sex differences in this relationship in an elderly Japanese population. Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in the Tsurugaya area, Sendai, Japan (N=2,925). Of those who participated (N=958), the 841 who gave informed consent and were not qualified for certification of long-term care insurance use at the baseline survey were analyzed. Depression was assessed using the 30-item Geriatric Depression Scale (GDS). We classified the subjects into three categories: normal (GDS less than 10), mild depression (GDS between 10 and 13), and moderate to severe depression (GDS more than 13 and/or taking antidepressive medication). The hazard ratio of incident certification of long-term care insurance use by depressive status was calculated using the Cox proportional hazards model. Results During 4 years of follow-up, a total of 151 subjects were certificated for long-term care insurance and 46 subjects died. Particularly in men, the depressive status was related to subsequent incident certification of long-term care insurance use. In men, the age-adjusted hazard ratios (HRs) were 1.77 (95% confidence interval (CI): 0.91-3.48) for mild depression, and 2.26 (1.11-4.64) for moderate to severe depression (P for trend=0.023). The relationship between depressive status and subsequent certification of long-term care insurance use in men was significant even after adjustment for age, comorbid conditions, social factors and lifestyle (multivariate-adjusted HR: 1.31 (95% CI: 0.65-2.65); mild depression 2.19 (1.06-4.54); moderate to severe depression: P for trend=0.034). In women, there was no significant association between depressive status and certification of long-term care insurance use. In both sexes, there was no significant association between depressive status and death. Conclusion The relationship between depressive status and subsequent certification of long-term care insurance use was significant only in men. In men, the relationship was significant even after adjustment for age, comorbid conditions, social factors and lifestyle. These results suggest a sex difference in the relationship between depressive status and subsequent certification of long-term care insurance use in elderly Japanese.
うつ状態と介護保険要支援・要介護認定リスクとの関連鶴ヶ谷プロジェクト Peer-reviewed

大森芳, 松田, 寳澤篤, 曽根稔雅, 小泉弥生, 正宗, 中谷直樹, 栗山進一, 鈴木修治, 粟田主一, 辻一郎

日本公衆衛生雑誌　57　(7)　538-549　2010/07
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.57.7_538 　

ISSN： 0546-1766

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Objective The purpose of this study was to examine the relationship between depressive status and subsequent certification of long-term care insurance use, and to investigate sex differences in this relationship in an elderly Japanese population. Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in the Tsurugaya area, Sendai, Japan (N=2,925). Of those who participated (N=958), the 841 who gave informed consent and were not qualified for certification of long-term care insurance use at the baseline survey were analyzed. Depression was assessed using the 30-item Geriatric Depression Scale (GDS). We classified the subjects into three categories: normal (GDS less than 10), mild depression (GDS between 10 and 13), and moderate to severe depression (GDS more than 13 and/or taking antidepressive medication). The hazard ratio of incident certification of long-term care insurance use by depressive status was calculated using the Cox proportional hazards model. Results During 4 years of follow-up, a total of 151 subjects were certificated for long-term care insurance and 46 subjects died. Particularly in men, the depressive status was related to subsequent incident certification of long-term care insurance use. In men, the age-adjusted hazard ratios (HRs) were 1.77 (95% confidence interval (CI): 0.91-3.48) for mild depression, and 2.26 (1.11-4.64) for moderate to severe depression (P for trend=0.023). The relationship between depressive status and subsequent certification of long-term care insurance use in men was significant even after adjustment for age, comorbid conditions, social factors and lifestyle (multivariate-adjusted HR: 1.31 (95% CI: 0.65-2.65); mild depression 2.19 (1.06-4.54); moderate to severe depression: P for trend=0.034). In women, there was no significant association between depressive status and certification of long-term care insurance use. In both sexes, there was no significant association between depressive status and death. Conclusion The relationship between depressive status and subsequent certification of long-term care insurance use was significant only in men. In men, the relationship was significant even after adjustment for age, comorbid conditions, social factors and lifestyle. These results suggest a sex difference in the relationship between depressive status and subsequent certification of long-term care insurance use in elderly Japanese.
【肥満とやせ】肥満の健康影響 Invited

栗山進一

公衆衛生　74　(6)　462-468　2010/06

DOI： 10.11477/mf.1401101817 　
The Ohsaki Cohort 2006 Study: Design of Study and Profile of Participants at Baseline Peer-reviewed

Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Yasutake Tomata, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　20　(3)　253-258　2010/05

DOI： 10.2188/jea.JE20090093 　

ISSN： 0917-5040
Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women Peer-reviewed

Kemmyo Sugiyama, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Masato Nagai, Yumi Sugawara, Atsushi Hozawa, Akira Fukao, Ichiro Tsuji

JOURNAL OF NUTRITION　140　(5)　1007-1013　2010/05

DOI： 10.3945/jn.109.109314 　

ISSN： 0022-3166
Association between green tea consumption and tooth loss: Cross-sectional results from the Ohsaki Cohort 2006 Study Peer-reviewed

Yasushi Koyama, Shinichi Kuriyama, Jun Aida, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Ichiro Tsuji

PREVENTIVE MEDICINE　50　(4)　173-179　2010/04

DOI： 10.1016/j.ypmed.2010.01.010 　

ISSN： 0091-7435
Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris Peer-reviewed

Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa

CIRCULATION JOURNAL　74　(3)　589-591　2010/03

DOI： 10.1253/circj.CJ-09-1028 　

ISSN： 1346-9843
Green Tea Consumption and Prevention of Coronary Artery Disease Peer-reviewed

Shinichi Kuriyama

CIRCULATION JOURNAL　74　(2)　248-249　2010/02

DOI： 10.1253/circj.CJ-09-1004 　

ISSN： 1346-9843
Difference in lifetime medical expenditures between male smokers and non-smokers Peer-reviewed

Kenshi Hayashida, Yuichi Imanaka, Genki Murakami, Yuko Takahashi, Masato Nagai, Shinichi Kuriyama, Ichiro Tsuji

HEALTH POLICY　94　(1)　84-89　2010/01

DOI： 10.1016/j.healthpol.2009.08.007 　

ISSN： 0168-8510
Reproductive factors, exogenous female hormone use and breast cancer risk in Japanese: the Miyagi Cohort Study Peer-reviewed

Masaaki Kawai, Yuko Minami, Shinichi Kuriyama, Masako Kakizaki, Yoichiro Kakugawa, Yoshikazu Nishino, Takanori Ishida, Akira Fukao, Ichiro Tsuji, Noriaki Ohuchi

CANCER CAUSES & CONTROL　21　(1)　135-145　2010/01

DOI： 10.1007/s10552-009-9443-7 　

ISSN： 0957-5243
Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study Peer-reviewed

Yasutake Monma, Kaijun Niu, Koh Iwasaki, Naoki Tomita, Naoki Nakaya, Atsushi Hozawa, Shinichi Kuriyama, Shin Takayama, Takashi Seki, Takashi Takeda, Nobuo Yaegashi, Satoru Ebihara, Hiroyuki Arai, Ryoichi Nagatomi, Ichiro Tsuji

BMC GERIATRICS　10　31-31　2010

DOI： 10.1186/1471-2318-10-31 　

ISSN： 1471-2318
Relationship between Peripheral Arterial Disease and Incident Disability among Elderly Japanese: the Tsurugaya Project Peer-reviewed

Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　17　(12)　1290-1296　2010

DOI： 10.5551/jat.5389 　

ISSN： 1340-3478

eISSN： 1880-3873
Green tea consumption is associated with depressive symptoms in the elderly Peer-reviewed

Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Satoru Ebihara, Hui Guo, Naoki Nakaya, Kaori Ohmori-Matsuda, Hideko Takahashi, Yayoi Masamune, Masanori Asada, Satoshi Sasaki, Hiroyuki Arai, Shuichi Awata, Ryoichi Nagatomi, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(6)　1615-1622　2009/12

DOI： 10.3945/ajcn.2009.28216 　

ISSN： 0002-9165
Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study Peer-reviewed

Akane Ui, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

CANCER CAUSES & CONTROL　20　(10)　1939-1945　2009/12

DOI： 10.1007/s10552-009-9388-x 　

ISSN： 0957-5243
Factors Associated With Psychological Distress in a Community-Dwelling Japanese Population: The Ohsaki Cohort 2006 Study Peer-reviewed

Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Taichi Shimazu, Nobutaka Kikuchi, Masako Kakizaki, Toshimasa Sone, Fumi Sato, Masato Nagai, Yumi Sugawara, Munira Akhter, Mizuka Higashiguchi, Naru Fukuchi, Hideko Takahashi, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　19　(6)　294-302　2009/11

DOI： 10.2188/jea.JE20080076 　

ISSN： 0917-5040
Green tea consumption is associated with lower psychological distress in a general population: the Ohsaki Cohort 2006 Study Peer-reviewed

Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Masako Kakizaki, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Akemi Nitta, Yasutake Tomata, Kaijun Niu, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(5)　1390-1396　2009/11

DOI： 10.3945/ajcn.2009.28214 　

ISSN： 0002-9165
Mental Vulnerability and Survival After Cancer Peer-reviewed

Naoki Nakaya, Pernille E. Bidstrup, Lene F. Eplov, Kumi Saito-Nakaya, Shinichi Kuriyama, Ichiro Tsuji, Yosuke Uchitomi, Christoffer Johansen

EPIDEMIOLOGY　20　(6)　916-920　2009/11

DOI： 10.1097/EDE.0b013e3181b5f3b0 　

ISSN： 1044-3983
体格と生涯医療費の関連大崎国保コホート研究

永井雅人, 栗山進一, 柿崎真沙子, 大森芳, 寳澤篤, 橋本修二, 辻一郎

日本公衆衛生学会総会抄録集　68回　279-279　2009/10
要介護認定に対する基本チェックリストの予測妥当性の検証大崎コホート2006研究 Peer-reviewed

遠又靖丈, 寳澤篤, 大森芳, 永井雅人, 菅原由美, 新田明美, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　68回　216-216　2009/10
Green tea and death from pneumonia in Japan: the Ohsaki cohort study Peer-reviewed

Ikue Watanabe, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Kaori Ohmori-Matsuda, Naoki Nakaya, Atsushi Hozawa, Ichiro Tsuji

AMERICAN JOURNAL OF CLINICAL NUTRITION　90　(3)　672-679　2009/09

DOI： 10.3945/ajcn.2009.27599 　

ISSN： 0002-9165

eISSN： 1938-3207
体格が平均余命に及ぼす影響大崎国保コホート研究 Peer-reviewed

永井雅人, 栗山進一, 寳澤篤, 辻一郎

肥満研究　15　(Suppl.)　200-200　2009/09
Green Tea Consumption and Hematologic Malignancies in Japan Peer-reviewed

Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

AMERICAN JOURNAL OF EPIDEMIOLOGY　170　(6)　730-738　2009/09

DOI： 10.1093/aje/kwp187 　

ISSN： 0002-9262
Effect of screening mammography on breast cancer survival in comparison to other detection methods: A retrospective cohort study Peer-reviewed

Masaaki Kawai, Shinichi Kuriyama, Akihiko Suzuki, Yoshikazu Nishino, Takanori Ishida, Koji Ohnuki, Masakazu Amari, Ichiro Tsuji, Noriaki Ohuchi

CANCER SCIENCE　100　(8)　1479-1484　2009/08

DOI： 10.1111/j.1349-7006.2009.01212.x 　

ISSN： 1347-9032
Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma Peer-reviewed

Yukika Kakuta, Naoki Nakaya, Satoru Nagase, Megumi Fujita, Toshimitsu Koizumi, Chikako Okamura, Hitoshi Niikura, Kaori Ohmori, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yuko Minami, Nobuo Yaegashi, Ichiro Tsuji

CANCER CAUSES & CONTROL　20　(5)　617-624　2009/07

DOI： 10.1007/s10552-008-9272-0 　

ISSN： 0957-5243
家庭血圧で測定された血圧の季節変動性についての検討 Peer-reviewed

寳澤篤, 栗山進一, 島津太一, 大森芳, 辻一郎

東北公衆衛生学会誌　(58)　20-20　2009/07
音過敏を有する広汎性発達障害事例に対するピリドキシン投与の有効性評価 Peer-reviewed

上山真知子, 栗山進一, 渡辺瑞香子

脳と発達　41　(Suppl.)　S345-S345　2009/05
Increase in body mass index category since age 20 years and all-cause mortality: a prospective cohort study (the Ohsaki Study). Peer-reviewed

Shimazu T, Kuriyama S, Ohmori-Matsuda K, Kikuchi N, Nakaya N, Tsuji I

International journal of obesity (2005)　33　(4)　490-496　2009/04
Publisher: 4
DOI： 10.1038/ijo.2009.29 　

ISSN： 0307-0565
Attributable Risk Fraction of Prehypertension on Cardiovascular Disease Mortality in the Japanese Population: The Ohsaki Study Peer-reviewed

Atsushi Hozawa, Shinichi Kuriyama, Masako Kakizaki, Kaori Ohmori-Matsuda, Takayoshi Ohkubo, Ichiro Tsuji

AMERICAN JOURNAL OF HYPERTENSION　22　(3)　267-272　2009/03

DOI： 10.1038/ajh.2008.335 　

ISSN： 0895-7061
Pain and Risk of Completed Suicide in Japanese Men: A Population-Based Cohort Study in Japan (Ohsaki Cohort Study) Peer-reviewed

Nobutaka Kikuchi, Kaori Ohmori-Matsuda, Taichi Shimazu, Toshimasa Sone, Masako Kakizaki, Naoki Nakaya, Shinichi Kuriyama, Ichiro Tsuji

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT　37　(3)　316-324　2009/03

DOI： 10.1016/j.jpainsymman.2008.03.012 　

ISSN： 0885-3924
Personality and Gastric Cancer Screening Attendance: A Cross-Sectional Analysis from the Miyagi Cohort Study Peer-reviewed

Shizuha Arai, Naoki Nakaya, Masako Kakizaki, Kaori Ohmori-Matsuda, Taichi Shimazu, Shinichi Kuriyama, Akira Fukao, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　19　(1)　34-40　2009/01

DOI： 10.2188/jea.JE20080024 　

ISSN： 0917-5040
Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan The Miyagi Cohort Study Peer-reviewed

Toru Naganuma, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Naoki Nakaya, Kaori Ohmori-Matsuda, Yoshikazu Nishino, Akira Fukao, Ichiro Tsuji

AMERICAN JOURNAL OF EPIDEMIOLOGY　168　(12)　1425-1432　2008/12

DOI： 10.1093/aje/kwn282 　

ISSN： 0002-9262
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study Peer-reviewed

Iwama N, Metoki H, Nishigori H, Mizuno S, Takahashi F, Tanaka K, Watanabe Z, Saito M, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Sugiyama T, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N

Hypertens Res　2008/11
Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study. Peer-reviewed

Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N, Fukudo S, Tsuji I

British journal of cancer　99　(9)　1502-1505　2008/11
Publisher: 9
DOI： 10.1038/sj.bjc.6604684 　

ISSN： 0007-0920

eISSN： 1532-1827
Age-specific interval breast cancers in Japan: estimation of the proper sensitivity of screening using a population-based cancer registry Peer-reviewed

Akihiko Suzuki, Shinichi Kuriyama, Masaaki Kawai, Masakazu Amari, Motohiro Takeda, Takanori Ishida, Koji Ohnuki, Yoshikazu Nishino, Ichiro Tsuji, Daisuke Shibuya, Noriaki Ohuchi

CANCER SCIENCE　99　(11)　2264-2267　2008/11

DOI： 10.1111/j.1349-7006.2008.00926.x 　

ISSN： 1347-9032
No effect of the Trp64Arg variant of the beta(3)-adrenergic receptor gene on weight loss by diet and exercise intervention among Japanese adults Peer-reviewed

Shinichi Kuriyama, Taichi Shimazu, Atsushi Hozawa, Shigeo Kure, Naoyuki Kurokawa, Masako Kakizaki, Toshimasa Sone, Kaori Matsuda-Ohmori, Naoki Nakaya, Hiroshi Satoh, Ichiro Tsuji

METABOLISM-CLINICAL AND EXPERIMENTAL　57　(11)　1570-1575　2008/11

DOI： 10.1016/j.metabol.2008.06.013 　

ISSN： 0026-0495
Green tea consumption and lung cancer risk: the Ohsaki study. Peer-reviewed

Li Q, Kakizaki M, Kuriyama S, Sone T, Yan H, Nakaya N, Mastuda-Ohmori K, Tsuji I

British journal of cancer　99　(7)　1179-1184　2008/10
Publisher: 7
DOI： 10.1038/sj.bjc.6604645 　

ISSN： 0007-0920

eISSN： 1532-1827
年齢階級別のBMIと全死因死亡リスクを検討した前向きコホート研究 Peer-reviewed

永井雅人, 栗山進一, 寳澤篤, 辻一郎

肥満研究　14　(Suppl.)　139-139　2008/09
Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma Peer-reviewed

Toshimitsu Koizumi, Naoki Nakaya, Chikako Okamura, Yuki Sato, Taichi Shimazu, Satoru Nagase, Hitoshi Niikura, Shinichi Kuriyama, Toru Tase, Kiyoshi Ito, Yoshitaka Tsubono, Kunihiro Okamura, Nobuo Yaegashi, Ichiro Tsuj

EUROPEAN JOURNAL OF CANCER PREVENTION　17　(4)　358-363　2008/08

DOI： 10.1097/CEJ.0b013e3282f0c02c 　

ISSN： 0959-8278
The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies Invited

Shinichi Kuriyama

JOURNAL OF NUTRITION　138　(8)　1548-1553　2008/08

ISSN： 0022-3166

eISSN： 1541-6100
Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study. Peer-reviewed

Kakizaki M, Inoue K, Kuriyama S, Sone T, Matsuda-Ohmori K, Nakaya N, Fukudo S, Tsuji I, Ohsaki Cohort Study

British journal of cancer　99　176-178　2008/07
Publisher: 1
DOI： 10.1038/sj.bjc.6604425 　

ISSN： 0007-0920
Body mass index and cardiovascular disease mortality in Japan: The Ohsaki Study Peer-reviewed

Satoshi Funada, Taichi Shimazu, Masako Kakizaki, Shinichi Kuriyama, Yuki Sato, Kaori Matsuda-Ohmori, Yoshikazu Nishino, Ichiro Tsuji

PREVENTIVE MEDICINE　47　(1)　66-70　2008/07

DOI： 10.1016/j.ypmed.2008.03.010 　

ISSN： 0091-7435
Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study Peer-reviewed

Toshimasa Sone, Naoki Nakaya, Kaori Ohmori, Taichi Shimazu, Mizuka Higashiguchi, Masako Kakizaki, Nobutaka Kikuchi, Shinichi Kuriyama, Ichiro Tsuji

PSYCHOSOMATIC MEDICINE　70　(6)　709-715　2008/07

DOI： 10.1097/PSY.0b013e31817e7e64 　

ISSN： 0033-3174
低栄養と介護保険認定・死亡リスクに関するコホート研究鶴ヶ谷プロジェクト Peer-reviewed

東口みづか, 中谷直樹, 大森芳, 島津太一, 曽根稔雅, 寳澤篤, 栗山進一, 辻一郎

日本公衆衛生雑誌　55　(7)　433-439　2008/07
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.55.7_433 　

ISSN： 0546-1766

More details Close

Objective The purpose of this study was to propose a suitable cut-off point for the serum albumin value to predict which elderly individuals are qualified for long-term care insurance certification and those at risk of death. Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in Sendai, Japan. Of those participating, the 832 from whom consent was obtained and who were not qualified for long-term care insurance certification were adopted as subjects. Cut-off points on serum albumin levels were set every 0.1 g/dL from 3.5 g/dL to 4.0 g/dL. The risk of incident certification of long-term care insurance or death (calculated by the Cox proportional hazards model), the frequency of the subjects, the sensitivity, the specificity and the positive predictive value of the category below each cut-off point were calculated. Results During 3 years follow-up, a total of 130 subjects either became certificated for long-term care insurance or died. On multivariate analyses, the risk of incident certification of long-term care insurance or death showed significantly increase with all cut-off points. The frequencies were 1.3% at 3.5 g/dL, 9.6% at 3.8 g/dL and 29.6% at 4.0 g/dL. The sensitivities were 5.4% at 3.5 g/dL, 18.5% at 3.8 g/dL and 45.4% at 4.0 g/dL. The specificities were 99.4% at 3.5 g/dL, 92.0% at 3.8 g/dL and 73.4% at 4.0 g/dL. The positive predictive values were 63.6% at 3.5 g/dL, 30.0% at 3.8 g/dL and 24.0% at 4.0 g/dL. When the serum albumin cut-off point was set to 3.8 g/dL and the highest tertile level of the serum albumin value was used as a reference category, the sex- and age-adjusted hazard ratios (95% confidence intervals) were 2.1 (1.1-3.9) in those with serum albumin ≤3.8 g/dL, 1.5 (0.9-2.5) in those with the lowest tertile level and 1.0 (0.6-1.7) in those with the middle tertile level. Conclusion This study suggested that a serum albumin value of 3.8 g/dL is a suitable cut-off point with regard to sensitivity, specificity and positive predictive value.
[Malnutrition and the risk of long-term care insurance certification or mortality. A cohort study of the Tsurugaya project]. Peer-reviewed

Higashiguchi Mizuka, Nakaya Naoki, Ohmori Kaori, Shimazu Taichi, Sone Toshimasa, Hozawa Atsushi, Kuriyama Shinichi, Tsuji Ichiro

Nippon Koshu Eisei Zasshi　55　(7)　433-439　2008/07
Publisher: Japanese Society of Public Health
DOI： 10.11236/jph.55.7_433 　

ISSN： 0546-1766

More details Close

Objective The purpose of this study was to propose a suitable cut-off point for the serum albumin value to predict which elderly individuals are qualified for long-term care insurance certification and those at risk of death. Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly persons aged 70 years or older in Sendai, Japan. Of those participating, the 832 from whom consent was obtained and who were not qualified for long-term care insurance certification were adopted as subjects. Cut-off points on serum albumin levels were set every 0.1 g/dL from 3.5 g/dL to 4.0 g/dL. The risk of incident certification of long-term care insurance or death (calculated by the Cox proportional hazards model), the frequency of the subjects, the sensitivity, the specificity and the positive predictive value of the category below each cut-off point were calculated. Results During 3 years follow-up, a total of 130 subjects either became certificated for long-term care insurance or died. On multivariate analyses, the risk of incident certification of long-term care insurance or death showed significantly increase with all cut-off points. The frequencies were 1.3% at 3.5 g/dL, 9.6% at 3.8 g/dL and 29.6% at 4.0 g/dL. The sensitivities were 5.4% at 3.5 g/dL, 18.5% at 3.8 g/dL and 45.4% at 4.0 g/dL. The specificities were 99.4% at 3.5 g/dL, 92.0% at 3.8 g/dL and 73.4% at 4.0 g/dL. The positive predictive values were 63.6% at 3.5 g/dL, 30.0% at 3.8 g/dL and 24.0% at 4.0 g/dL. When the serum albumin cut-off point was set to 3.8 g/dL and the highest tertile level of the serum albumin value was used as a reference category, the sex- and age-adjusted hazard ratios (95% confidence intervals) were 2.1 (1.1-3.9) in those with serum albumin ≤3.8 g/dL, 1.5 (0.9-2.5) in those with the lowest tertile level and 1.0 (0.6-1.7) in those with the middle tertile level. Conclusion This study suggested that a serum albumin value of 3.8 g/dL is a suitable cut-off point with regard to sensitivity, specificity and positive predictive value.
肥満・生活習慣病の予防に関する疫学研究 Peer-reviewed

栗山進一

東北医学雑誌　120　(1)　39-41　2008/06

ISSN： 0040-8700
Negative psychological aspects and survival in lung cancer patients Peer-reviewed

Naoki Nakaya, Kumi Saito-Nakaya, Tatsuo Akechi, Shinichi Kuriyama, Masatoshi Inagaki, Nobutaka Kikuchi, Kanji Nagai, Shoichiro Tsugane, Yutaka Nishiwaki, Ichiro Tsuji, Yosuke Uchitomi

PSYCHO-ONCOLOGY　17　(5)　466-473　2008/05

DOI： 10.1002/pon.1259 　

ISSN： 1057-9249
Association between nocturia and fractures in a community-dwelling elderly population aged 70 years and over: Results of a 3-year prospective cohort study in Japan Peer-reviewed

Nakagawa Haruo, Ikeda Yoshihiro, Kaiho Yasuhiro, Nakaya Naoki, Omori Kaori, Niu Kaun, Kuriyama Shinichi, Nagatomi Ryoichi, Tsuji Ichiro, Arai Ydichi

JOURNAL OF UROLOGY　179　(4)　143　2008/04

DOI： 10.1016/S0022-5347(08)60410-3 　

ISSN： 0022-5347
Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: A population-based, cross-sectional analysis Peer-reviewed

Kaijun Niu, Atsushi Hozawa, Shuichi Awata, Hui Guo, Shinichi Kuriyama, Toru Sek, Kaori Ohmori-Matsuda, Naoki Nakaya, Satoru Ebihara, Yun Wang, Ichiro Tsuji, Ryoichi Nagatomi

HYPERTENSION RESEARCH　31　(3)　409-416　2008/03

DOI： 10.1291/hypres.31.409 　

ISSN： 0916-9636

eISSN： 1348-4214
地域高齢者の今高齢者を対象とした疫学研究より大崎国保コホート高齢者と医療費 Peer-reviewed

栗山進一

日本老年医学会雑誌　45　(2)　172-174　2008/03

DOI： 10.3143/geriatrics.45.172 　
[The Ohsaki National Health Insurance Beneficiaries Cohort Study: Medical costs in elderly Japanese]. Peer-reviewed

Kuriyama Shinichi

Nippon Ronen Igakkai Zasshi　45　(2)　172-174　2008/03

DOI： 10.3143/geriatrics.45.172 　
Personality and body mass index: A cross-sectional analysis from the Miyagi Cohort Study Peer-reviewed

Masako Kakizaki, Shinichi Kuriyarna, Yuki Sato, Taichi Shimazu, Kaori Matsuda-Ohmori, Naoki Nakaya, Akira Fukao, Shin Fukudo, Ichiro Tsuji

JOURNAL OF PSYCHOSOMATIC RESEARCH　64　(1)　71-80　2008/01

DOI： 10.1016/j.jpsychores.2007.07.008 　

ISSN： 0022-3999
Prevalence and clinicoepidemiological features of moyamoya disease in Japan - Findings from a nationwide epidemiological survey Peer-reviewed

Shinichi Kuriyama, Yasuko Kusaka, Miki Fujimura, Kenji Wakai, Akiko Tamakoshi, Shuji Hashimoto, Ichiro Tsuji, Yutaka Inaba, Takashi Yoshimoto

STROKE　39　(1)　42-47　2008/01

DOI： 10.1161/STROKEAHA.107.490714 　

ISSN： 0039-2499
Fish intake and the risk of prostate cancer in Japan: A prospective cohort study

Fumi Sato, Taichi Shimazu, Shinichi Kuriyama, Kaori Ohmori, Naoki Nakaya, Ichiro Tsuji, Yoichi Arai

Japanese Journal of Urology　99　(1)　14-21　2008
Publisher: Japanese Urological Association
DOI： 10.5980/jpnjurol1989.99.14 　

ISSN： 0021-5287
Fish intake and the risk of prostate cancer in Japan: A prospective cohort study Peer-reviewed

Fumi Sato, Taichi Shimazu, Shinichi Kuriyama, Kaori Ohmori, Naoki Nakaya, Ichiro Tsuji, Yoichi Arai

Japanese Journal of Urology　99　(1)　14-21　2008
Publisher: Japanese Urological Association
DOI： 10.5980/jpnjurol1989.99.14 　

ISSN： 0021-5287
Serum C-Reactive Protein Even at Very Low (< 1.0 mg/l) Concentration Is Associated with Physical Performance in a Community-Based Elderly Population Aged 70 Years and Over Peer-reviewed

Kaijun Niu, Atsushi Hozawa, Hui Guo, Shinichi Kuriyama, Satoru Ebihara, Guang Yang, Kaori Ohmori-Matsuda, Naoki Nakaya, Hideko Takahashi, Kazuki Fujita, Shirong Wen, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

GERONTOLOGY　54　(5)　260-267　2008

DOI： 10.1159/000134286 　

ISSN： 0304-324X
Survival prediction of patients with advanced cancer: The predictive accuracy of the model based on biological markers Peer-reviewed

Nobutaka Kikuchi, Kaori Ohmori, Shinichi Kuriyama, Akira Shimada, Toshimichi Nakaho, Makoto Yamamuro, Ichiro Tsuji

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT　34　(6)　600-606　2007/12

DOI： 10.1016/j.jpainsymman.2007.06.001 　

ISSN： 0885-3924
Alcohol consumption and suicide mortality among Japanese men: the Ohsaki Study Peer-reviewed

Naoki Nakaya, Nobutaka Kikuchi, Taichi Shimazu, Kaori Ohmori, Masako Kakizaki, Toshimasa Sone, Shuichi Awata, Shinichi Kuriyama, Ichiro Tsuji

ALCOHOL　41　(7)　503-510　2007/11

DOI： 10.1016/j.alcohol.2007.08.001 　

ISSN： 0741-8329
Time spent walking and risk of colorectal cancer in Japan: The Miyaqi Cohort Study Peer-reviewed

Hideko Takahashi, Shinichi Kuriyama, Yoshitaka Tsubono, Naoki Nakaya, Kazuki Fujita, Yoshikazu Nishino, Daisuke Shibuya, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER PREVENTION　16　(5)　403-408　2007/10

DOI： 10.1097/01.cej.0000236249.63489.05 　

ISSN： 0959-8278
潰瘍性大腸炎緩解維持療法におけるメサラジン週末注腸療法費用対効果、QOL解析

横山大, 高木承, 栗山進一, 高橋秀一郎, 高橋広喜, 岩渕正広, 高橋成一, 木内喜孝, 樋渡信夫, 辻一郎, 下瀬川徹

日本消化器病学会雑誌　104　(臨増大会)　A655-A655　2007/09
Publisher: (一財)日本消化器病学会
ISSN： 0446-6586

eISSN： 1349-7693
Effect of weekend 5-aminosalicylic acid (Mesalazine) enema as maintenance therapy for ulcerative colitis: Results from a Randomized controlled study Peer-reviewed

Hiroshi Yokoyama, Sho Takagi, Shinichi Kuriyama, Shuichiro Takahashi, Hiroki Takahashi, Masahiro Iwabuchi, Seiichi Takahashi, Yoshitaka Kinouchi, Nobuo Hiwatashi, Ichiro Tsuji, Tooru Shimosegawa

INFLAMMATORY BOWEL DISEASES　13　(9)　1115-1120　2007/09

DOI： 10.1002/ibd.20158 　

ISSN： 1078-0998
Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study Peer-reviewed

Taichi Shimazu, Shinichi Kuriyama, Atsushi Hozawa, Kaori Ohmori, Yuki Sato, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　36　(3)　600-609　2007/06

DOI： 10.1093/ije/dym005 　

ISSN： 0300-5771
シックハウス症候群が疑われる児童・生徒の心身の発達に関する調査研究 Peer-reviewed

上山真知子, 渡辺瑞香子, 栗山進一, 角田和彦

脳と発達　39　(Suppl.)　S293-S293　2007/06
地域高齢者の今:高齢者を対象とした疫学研究より大崎国保コホート研究高齢者と医療費 Peer-reviewed

栗山進一

日本老年医学会雑誌　44　(Suppl.)　27-27　2007/05
The joint impact of cardiovascular risk factors upon medical costs Peer-reviewed

Kaori Ohmori-Matsuda, Shinichi Kuriyama, Atsushi Hozawa, Naoki Nakaya, Taichi Shimazu, Ichiro Tsuji

PREVENTIVE MEDICINE　44　(4)　349-355　2007/04

DOI： 10.1016/j.ypmed.2006.11.020 　

ISSN： 0091-7435
Cigarette smoking and the risk of colorectal cancer among men: a prospective study in Japan Peer-reviewed

Munlra Akhter, Yoshikazu Nishino, Naoki Nakaya, Kayoko Kurashima, Yuki Sato, Shinichi Kuriyama, Yoshitaka Tsubono, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER PREVENTION　16　(2)　102-107　2007/04

DOI： 10.1097/01.cej.0000228412.98847.bc 　

ISSN： 0959-8278
Decrease in risk of lung cancer death in Japanese men after smoking cessation by age at quitting: Pooled analysis of three large-scale cohort studies Peer-reviewed

Kenji Wakai, Tomomi Marugame, Shinichi Kuriyama, Tomotaka Sobue, Akiko Tamakoshi, Hiroshi Satoh, Kazuo Tajima, Takaichiro Suzuki, Shoichiro Tsugane

CANCER SCIENCE　98　(4)　584-589　2007/04

DOI： 10.1111/j.1349-7006.2007.00423.x 　

ISSN： 1347-9032
Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan Peer-reviewed

Toru Naganuma, Shinichi Kuriyama, Munira Akhter, Masako Kakizaki, Naoki Nakaya, Kaori Matsuda-Ohmori, Taichi Shimazu, Akira Fukao, Ichiro Tsuji

INTERNATIONAL JOURNAL OF CANCER　120　(7)　1542-1547　2007/04

DOI： 10.1002/ijc.22505 　

ISSN： 0020-7136
超音波による乳癌検診は死亡率を減少させるかシミュレーション分析による40歳代超音波乳がん検診の救命効果および効率の検討

栗山進一, 大貫幸二, 鈴木昭彦, 市村みゆき, 森久保寛, 東野英利子, 辻一郎, 大内憲明

日本乳癌検診学会誌　16　(1)　93-98　2007/03

DOI： 10.3804/jjabcs.16.93 　
Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents Peer-reviewed

S. Awata, P. Bech, Y. Koizum, T. Seki, S. Kuriyama, A. Hozawa, K. Ohmori, N. Nakaya, H. Matsuoka, I. Tsuji

INTERNATIONAL PSYCHOGERIATRICS　19　(1)　77-88　2007/02

DOI： 10.1017/S1041610206004212 　

ISSN： 1041-6102
Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: A population-based cohort study Peer-reviewed

Akira Miyamoto, Shinichi Kuriyama, Yoshikazu Nishino, Yoshitaka Tsubono, Naoki Nakaya, Kaori Ohmori, Kayoko Kurashima, Daisuke Shibuya, Ichiro Tsuji

PREVENTIVE MEDICINE　44　(1)　12-19　2007/01

DOI： 10.1016/j.ypmed.2006.07.016 　

ISSN： 0091-7435
Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study Peer-reviewed

Munira Akhter, Shinichi Kuriyama, Naoki Nakaya, Taichi Shimazu, Kaori Ohmori, Yoshikazu Nishino, Yoshitaka Tsubono, Akira Fukao, Ichiro Tsuji

EUROPEAN JOURNAL OF CANCER　43　(2)　383-390　2007/01

DOI： 10.1016/j.ejca.2006.09.020 　

ISSN： 0959-8049
Benefit of home blood pressure measurement after a finding of high blood pressure at community screening. Peer-reviewed

Atsushi Hozawa, Taichi Shimazu, Shinichi Kuriyama, Ichiro Tsuji

JOURNAL OF HYPERTENSION　24　210-210　2006/12

ISSN： 0263-6352
Cost-effectiveness analysis of screening modalities for breast cancer in Japan with special reference to women aged 40-49 years Peer-reviewed

Koji Ohnuki, Shinichi Kuriyama, Narumi Shoji, Yoshikazu Nishino, Ichiro Tsuji, Noriaki Ohuchi

CANCER SCIENCE　97　(11)　1242-1247　2006/11

DOI： 10.1111/j.1349-7006.2006.00296.x 　

ISSN： 1347-9032
Management of the pain associated with endometriosis: An update of the painful problems Peer-reviewed

Yuka Ozawa, Takashi Murakami, Yukihiro Terada, Nobuo Yaegashi, Kunihiro Okamura, Shinichi Kuriyama, Ichiro Tsuji

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE　210　(3)　175-188　2006/11

DOI： 10.1620/tjem.210.175 　

ISSN： 0040-8727

eISSN： 1349-3329
Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: a randomized-controlled trial Peer-reviewed

S. Takagi, K. Utsunomiya, S. Kuriyama, H. Yokoyama, S. Takahashi, M. Iwabuchi, H. Takahashi, S. Takahashi, Y. Kinouchi, N. Hiwatashi, Y. Funayama, I. Sasaki, I. Tsuji, T. Shimosegawa

ALIMENTARY PHARMACOLOGY & THERAPEUTICS　24　(9)　1333-1340　2006/11

DOI： 10.1111/j.1365-2036.2006.03120.x 　

ISSN： 0269-2813
高齢者のうつカウンセリング治療によるLUTSの変化 Peer-reviewed

池田義弘, 今西里佳, 中川晴夫, 竹本淳, 松下真史, 荒井陽一, 小泉弥生, 粟田主一, 大森芳, 寶沢篤, 西野善一, 栗山進一, 辻一郎

日本排尿機能学会誌　17　(1)　171-171　2006/09
Impact of non-dietary nutrients intake on misclassification in the estimation of nutrient intake in epidemiologic study Peer-reviewed

Mikiko Ogata, Shinichi Kuriyama, Yuki Sato, Taichi Shimazu, Naoki Nakaya, Kaori Ohmori, Atsushi Hozawa, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　16　(5)　193-200　2006/09

DOI： 10.2188/jea.16.193 　

ISSN： 0917-5040
Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men Peer-reviewed

Atsunobu Ishikawa, Shinichi Kuriyama, Yoshitaka Tsubono, Akira Fukao, Haruhiko Takahashi, Hidekiyo Tachiya, Ichiro Tsuji

JOURNAL OF EPIDEMIOLOGY　16　(5)　185-192　2006/09

DOI： 10.2188/jea.16.185 　

ISSN： 0917-5040
Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan - The Ohsaki Study Peer-reviewed

Shinichi Kuriyama, Taichi Shimazu, Kaori Ohmori, Nobutaka Kikuchi, Naoki Nakaya, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　296　(10)　1255-1265　2006/09

DOI： 10.1001/jama.296.10.1255 　

ISSN： 0098-7484
No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study Peer-reviewed

N. Kikuchi, K. Ohmori, T. Shimazu, N. Nakaya, S. Kuriyama, Y. Nishino, Y. Tsubono, I. Tsuji

BRITISH JOURNAL OF CANCER　95　(3)　371-373　2006/08

DOI： 10.1038/sj.bjc.6603230 　

ISSN： 0007-0920
Impact of overweight and obesity on medical care costs, all-cause mortality, and the risk of cancer in Japan Peer-reviewed

Shinichi Kuriyama

JOURNAL OF EPIDEMIOLOGY　16　(4)　139-144　2006/07

ISSN： 0917-5040
Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products Peer-reviewed

Kaijun Niu, Atsushi Hozawa, Shinichi Kuriyama, Kaori Ohmori-Matsuda, Taichi Shimazu, Naoki Nakaya, Kazuki Fujita, Ichiro Tsuji, Ryoichi Nagatomi

AMERICAN JOURNAL OF CLINICAL NUTRITION　84　(1)　223-229　2006/07

DOI： 10.1093/ajcn/84.1.223 　

ISSN： 0002-9165
Benefit of home blood pressure measurement after a finding of high blood pressure at a community screening Peer-reviewed

Atsushi Hozawa, Taichi Shimazu, Shinichi Kuriyama, Ichiro Tsuji

JOURNAL OF HYPERTENSION　24　(7)　1265-1271　2006/07

DOI： 10.1097/01.hjh.0000234105.23615.95 　

ISSN： 0263-6352
Meat consumption and risk of colorectal cancer in Japan: The Miyagi cohort study Peer-reviewed

Y Sato, N Nakaya, S Kuriyama, Y Nishino, Y Tsubono, Tsuji, I

EUROPEAN JOURNAL OF CANCER PREVENTION　15　(3)　211-218　2006/06

DOI： 10.1097/01.cej.0000197455.87356.05 　

ISSN： 0959-8278
Obesity and depressive symptoms in elderly Japanese: The Tsurugaya Project Peer-reviewed

S Kuriyama, Y Koizumi, K Matsuda-Ohmori, T Seki, T Shimazu, A Hozawa, S Awata, Tsuji, I

JOURNAL OF PSYCHOSOMATIC RESEARCH　60　(3)　229-235　2006/03

DOI： 10.1016/j.jpsychores.2005.07.010 　

ISSN： 0022-3999
Dietary intakes and plasma 8-iso-prostaglandin F-2 alpha concentrations in community-dwelling elderly Japanese: The Tsurugaya Project Peer-reviewed

Shinichi Kuriyama, Satoru Ebihara, Atsushi Hozawa, Kaori Ohmori, Kayoko Kurashima, Naoki Nakaya, Toshifumi Matsui, Hiroyuki Arai, Yoshitaka Tsubono, Hidetada Sasaki, Ichiro Tsuji

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH　76　(2)　87-94　2006/03

DOI： 10.1024/0300-9831.76.2.87 　

ISSN： 0300-9831
[Comparison of intensive and moderate individual life-style intervention programs for overweight or obese persons with fasting glucose levels of 95-125 mg/dl in Japan] Peer-reviewed

Kuriyama Shinichi, Shimazu Taichi, Hozawa Atsushi, Yabe Mitsuko, Tasaki Mikiko, Mononaga Yoko, Sakai Michiko, Miura Chihaya, Ito Fumie, Ito Takako, Yabe Hatsue, Nitta Sachie, Suzuki Reiko, Fujita Kazuki, Nagatomi Ryoichi, Tsuji Ichiro

Nippon Koshu Eisei Zasshi　53　(2)　122-132　2006/02

DOI： 10.11236/jph.53.2_122 　

ISSN： 0546-1766

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OBJECTIVES: There are considerable differences in individual health education programs for persons at high risk of type 2 diabetes between ordinary Japanese life-style modification programs and the Diabetes Prevention Program in the US, the former being relatively moderate and the latter more intensive. We therefore compared the effectiveness of intensive and moderate intervention, focusing on the frequency of individual educational classes. METHODS: The subjects were men and women aged 44-69 years living in Nishiaizu town, Fukushima prefecture in Japan. Their fasting plasma glucose concentration was between 95 and 125 mg/dl at health examinations conducted in 2002 or 2003. They also had a body mass index (BMI) of 23.0 or higher, a fasting plasma glucose concentration of 125 mg/dl or lower and a post-load plasma glucose concentration (2 h) of 199 mg/dl or lower in the 2004 survey. We assigned the subjects according to their residences to an intensive life-style intervention group (two education classes per month; n = 11) or a moderate intervention group (one education class per month; n = 14). The main outcome measure was the change in body weight after 6 months of intervention. RESULTS: The loss of body weight was -3.5 kg (P< .0001) in the intensive intervention group and -1.8 kg (P = 0.02) in the moderate group, and the net difference in body weight loss between the groups was -2.0 kg (95% confidence interval -4.0 to -0.05; P = 0.045) after adjustment for age, sex, and baseline body weight. BMI and subcutaneous fat area showed similar results. The post-load plasma glucose concentration (2 h) and other tested values showed no significant net change between the two groups. CONCLUSIONS: Intensive and moderate intervention both reduced body weight in overweight or obese persons at high risk of type 2 diabetes. The intensive intervention, two sessions of individual education classes per month, was significantly more effective than the moderate one for reducing body weight.
Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project Peer-reviewed

S Kuriyama, A Hozawa, K Ohmori, T Shimazu, T Matsui, S Ebihara, S Awata, R Nagatomi, H Arai, Tsuji, I

AMERICAN JOURNAL OF CLINICAL NUTRITION　83　(2)　355-361　2006/02

DOI： 10.1093/ajcn/83.2.355 　

ISSN： 0002-9165
A Clinical Study of Pyridoxine Treatment for Pervasive Developmental Disorders with Hypersensitivity to Sound

Kamiyama Machiko, Kuriyama Shinichi, Watanabe Mikako

NO TO HATTATSU　38　(4)　277-282　2006
Publisher: The Japanese Society of Child Neurology
DOI： 10.11251/ojjscn1969.38.277 　

ISSN： 1884-7668

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In our earlier study we conducted a randomized, placebo-controlled, triple blind trial, and showed that pyridoxine treatment of pervasive developmental disorders with expressive verbal disorders and hypersensitivity to sound as significantly effective in improving VIQ scores. This study analyzed the long-term changes of the subjects. We confirmed that their VIQ scores improved over time. An analysis of the reports of their daily life provided by their parents and teachers showed that the children's hypersensitivity to sound was also improved. They became able to adjust to their daily life at home and school without any panic. Our results indicate there are PDD subgroups whose expressive language capabilities and hypersensitivity to sound can be improved by pyridoxine treatment.
A clinical study of pyridoxine treatment for pervasive developmental disorders with hypersensitivity to sound Peer-reviewed

Machiko Kamiyama, Shinichi Kuriyama, Mikako Watanabe

No To Hattatsu　38　(4)　277-282　2006

ISSN： 0029-0831
Association between social support and depression status in the elderly: Results of a 1-year community-based prospective cohort study in Japan Peer-reviewed

Y Koizumi, S Awata, S Kuriyama, K Ohmori, A Hozawa, T Seki, H Matsuoka, Tsuji, I

PSYCHIATRY AND CLINICAL NEUROSCIENCES　59　(5)　563-569　2005/10

DOI： 10.1111/j.1440-1819.2005.01415.x 　

ISSN： 1323-1316
Influence of leisure-time physical activity on the relationship between C-reactive protein and hypertension in a community-based elderly population of Japan: The Tsurugaya Project Peer-reviewed

K Niu, A Hozawa, K Fujita, K Ohmori, M Okutsu, S Kuriyama, Tsuji, I, R Nagatomi

HYPERTENSION RESEARCH　28　(9)　747-754　2005/09

DOI： 10.1291/hypres.28.747 　

ISSN： 0916-9636
Coffee consumption and the risk of primary liver cancer: Pooled analysis of two prospective studies in Japan Peer-reviewed

T Shimazu, Y Tsubono, S Kuriyama, K Ohmori, Y Koizumi, Y Nishino, D Shibuya, Tsuji, I

INTERNATIONAL JOURNAL OF CANCER　116　(1)　150-154　2005/08

DOI： 10.1002/ijc.20989 　

ISSN： 0020-7136
Factors associated with suicidal ideation in an elderly urban Japanese population: A community-based, cross-sectional study Peer-reviewed

S Awata, T Seki, Y Koizumi, S Sato, A Hozawa, K Omori, S Kuriyama, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

PSYCHIATRY AND CLINICAL NEUROSCIENCES　59　(3)　327-336　2005/06

DOI： 10.1111/j.1440-1819.2005.01378.x 　

ISSN： 1323-1316
Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study Peer-reviewed

Y Sato, Y Tsubono, N Nakaya, K Ogawa, K Kurashima, S Kuriyama, A Hozawa, Y Nishino, D Shibuya, Tsuji, I

PUBLIC HEALTH NUTRITION　8　(3)　309-314　2005/05

DOI： 10.1079/PHN2004681 　

ISSN： 1368-9800
Alcohol consumption and the risk of cancer in Japanese men: the Miyagi cohort study Peer-reviewed

N Nakaya, Y Tsubono, S Kuriyama, A Hozawa, T Shimazu, K Kurashima, S Fukudo, D Shibuya, Tsuji, I

EUROPEAN JOURNAL OF CANCER PREVENTION　14　(2)　169-174　2005/04

DOI： 10.1097/00008469-200504000-00013 　

ISSN： 0959-8278
Personality and mortality from ischemic heart disease and stroke Peer-reviewed

N Nakaya, Y Tsubono, T Hosokawa, A Hozawa, S Kuriyama, S Fukudo, Tsuji, I

CLINICAL AND EXPERIMENTAL HYPERTENSION　27　(2-3)　297-305　2005/02

DOI： 10.1081/CEH-200048930 　

ISSN： 1064-1963
高齢者に対する尿失禁に関するアンケート調査と関連因子の解析(第93回日本泌尿器科学会総会)

池田義弘, 中川晴夫, 海法康裕, 竹本淳, 荒井陽一, 大森芳, 西野善一, 栗山進一, 辻一郎

日本泌尿器科学会雑誌　96　(2)　179-179　2005
Publisher: 一般社団法人日本泌尿器科学会
DOI： 10.5980/jpnjurol.96.179_2 　
The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community Peer-reviewed

K Ohmori, S Ebihara, S Kuriyama, T Ugajin, M Ogata, A Hozawa, T Matsui, Y Tsubono, H Arai, H Sasaki, Tsuji, I

ANNALS OF EPIDEMIOLOGY　15　(1)　80-84　2005/01

DOI： 10.1016/j.annepidem.2004.04.001 　

ISSN： 1047-2797
Impact of alcohol consumption upon medical care utilization and costs in men: 4-year observation of National Health Insurance beneficiaries in Japan Peer-reviewed

Y Anzai, S Kuriyama, Y Nishino, K Takahashi, T Ohkubo, K Ohmori, Y Tsubono, Tsuji, I

ADDICTION　100　(1)　19-27　2005/01

DOI： 10.1111/j.1360-0443.2004.00874.x 　

ISSN： 0965-2140
Obesity and risk of cancer in Japan Peer-reviewed

S Kuriyama, Y Tsubono, A Hozawa, T Shimazu, Y Suzuki, Y Koizumi, Y Suzuki, K Ohmori, Y Nishino, Tsuji, I

INTERNATIONAL JOURNAL OF CANCER　113　(1)　148-157　2005/01

DOI： 10.1002/ijc.20529 　

ISSN： 0020-7136
Modifiable factors for the length of life with disability before death: Mortality retrospective study in Japan Peer-reviewed

K Ohmori, S Kuriyama, A Hozawa, T Ohkubo, Y Tsubono, Tsuji, I

GERONTOLOGY　51　(3)　186-191　2005

DOI： 10.1159/000083992 　

ISSN： 0304-324X
C-reactive protein and peripheral artery disease among Japanese elderly: The Tsurugaya project Peer-reviewed

A Hozawa, K Ohmori, S Kuriyama, T Shimazu, K Niu, A Watando, S Ebihara, T Matsui, M Ichiki, R Nagatomi, H Sasaki, Tsuji, I

HYPERTENSION RESEARCH　27　(12)　955-961　2004/12

DOI： 10.1291/hypres.27.955 　

ISSN： 0916-9636
Joint impact of health risks on health care charges: 7-year follow-up of National Health Insurance beneficiaries in Japan (the Ohsaki Study) Peer-reviewed

S Kuriyama, A Hozawa, K Ohmori, Y Suzuki, Y Nishino, K Fujita, Y Tsubono, Tsuji, I

PREVENTIVE MEDICINE　39　(6)　1194-1199　2004/12

DOI： 10.1016/j.ypmed.2004.04.033 　

ISSN： 0091-7435
Cigarette smoking and the risk of gastric cancer: A pooled analysis of two prospective studies in Japan Peer-reviewed

Y Koizumi, Y Tsubono, N Nakaya, S Kuriyama, D Shibuya, H Matsuoka, Tsuji, I

INTERNATIONAL JOURNAL OF CANCER　112　(6)　1049-1055　2004/12

DOI： 10.1002/ijc.20518 　

ISSN： 0020-7136
Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study Peer-reviewed

T Watanabe, N Nakaya, K Kurashima, S Kuriyama, Y Tsubono, Tsuji, I

EUROPEAN JOURNAL OF CANCER　40　(14)　2109-2115　2004/09

DOI： 10.1016/j.ejca.2004.06.014 　

ISSN： 0959-8049
Increased plasma 8-isoprostane levels in hypertensive subjects: The Tsurugaya project Peer-reviewed

A Hozawa, S Ebihara, K Ohmori, S Kuriyama, T Ugajin, Y Koizumi, Y Suzuki, T Matsui, H Arai, Y Tsubono, H Sasaki, Tsuji, I

HYPERTENSION RESEARCH　27　(8)　557-561　2004/08

DOI： 10.1291/hypres.27.557 　

ISSN： 0916-9636
[A survey regarding the implementation of cancer screening among municipalities in Japan] Peer-reviewed

Nakaya Naoki, Ohmori Kaori, Suzuki Yoshinori, Hozawa Atsushi, Kuriyama Shinichi, Tsubono Yoshitaka, Tsuji Ichiro

Nippon Koshu Eisei Zasshi　51　(7)　530-539　2004/07

DOI： 10.11236/jph.51.7_530 　
がん検診の実施状況に関する市区町村実態調査 Peer-reviewed

中谷直樹, 大森芳, 鈴木寿則, 寳澤篤, 栗山進一, 坪野吉孝, 辻一郎

日本公衆衛生雑誌　51　(7)　530-539　2004/07

DOI： 10.11236/jph.51.7_530 　
Health practices and mortality in Japan: Combined effects of smoking, drinking, walking and body mass index in the Miyagi Cohort Study Peer-reviewed

Y Tsubono, Y Koizumi, N Nakaya, K Fujita, H Takahashi, A Hozawa, Y Suzuki, S Kuriyama, Tsuji, I, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S39-S45　2004/02

DOI： 10.2188/jea.14.S39 　

ISSN： 0917-5040
Body mass index and mortality in Japan: The Miyagi Cohort Study Peer-reviewed

S Kuriyama, K Ohmori, C Miura, Y Suzuki, N Nakaya, K Fujita, Y Sato, Y Tsubono, Tsuji, I, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S33-S38　2004/02

DOI： 10.2188/jea.14.S33 　

ISSN： 0917-5040
Cancer incidence profiles in the Miyagi Cohort Study Peer-reviewed

Y Nishino, Y Suzuki, K Ohmori, A Hozawa, K Ogawa, S Kuriyama, Y Tsubono, D Shibuya, Tsuji, I, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S7-S11　2004/02

DOI： 10.2188/jea.14.S7 　

ISSN： 0917-5040
Follow-up and mortality profiles in the Miyagi Cohort Study Peer-reviewed

Tsuji, I, Y Nishino, Y Tsubono, Y Suzuki, A Hozawa, N Nakaya, K Fujita, S Kuriyama, D Shibuya, A Fukao, S Hisamichi

JOURNAL OF EPIDEMIOLOGY　14　S2-S6　2004/02

DOI： 10.2188/jea.14.S2 　

ISSN： 0917-5040
高齢者におけるビタミンサプリメント摂取者の生活習慣に関する研究鶴ヶ谷寝たきり予防健診 (日本老年医学会雑誌)

尾形美樹子, 栗山進一, 寳澤篤, 大森芳, 松井敏史, 海老原覚, 荒井啓行, 佐々木英忠, 辻一郎

日本老年医学会雑誌　41　(Suppl.)　104-104　2004
Publisher:
ISSN： 0300-9173
Association between social support and depression in the elderly Japanese population Peer-reviewed

Koizumi Yayoi, Arai Hiroyuki, Tsuji Ichiro, Awata Shuichi, Seki Toru, Nakaya Naoki, Kuriyama Shinichi, Suzuki Yoshinori, Ohmori Kaori, Hozawa Atsushi, Ebihara Satoru

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics　41　(4)　426-433　2004
Publisher: The Japan Geriatrics Society
DOI： 10.3143/geriatrics.41.426 　

ISSN： 0300-9173

More details Close

To determine the association between social support and depression in elderly Japanese, we conducted a Comprehensive Geriatric Assessment among residents aged 70 years or over. Out of 2, 730 eligible subjects, 1, 179 participated in the survey and 1, 146 (480 men and 666 women) were analyzed. The Geriatric Depression Scale (GDS) was used to estimate depression status. The subjects were divided into two groups: depressive (GDS>11 or taking antidepressant drugs) and non-depressive (GDS<11). Various levels of social support were assessed by the following questions: Do you have someone (1) whom you can consult when you are in trouble? (2) whom you can consult when your physical condition is not good? (3) who can help you in daily housework? (4) who can take you to a hospital when you don't feel well? (5) who can take care of you when you are ill in bed? In multivariate logistic regression analysis, the calculated odds ratios (95% CIs) for the lack of each type of social support for depression status were: (1) 2.5 (1.5-4.1), (2) 1.9 (1.1-3.2), (3) 2.7 (1.7-4.4), (4) 1.9 (1.1-3.2), (5) 2.8 (1.6-4.9) in men, and (1) 1.2 (0.8-1.8), (2) 1.2 (0.8-1.8), (3) 1.4 (1.0-2.0), (4) 1.6 (1.1-2.3), (5) 2.0 (1.4-2.9) in women. A significant association was found between social support and depression in this elderly population. We also found that this association was stronger in men.
Impact of walking upon medical care expenditure in Japan: the Ohsaki Cohort Study Peer-reviewed

Tsuji, I, K Takahashi, Y Nishino, T Ohkubo, S Kuriyama, Y Watanabe, Y Anzai, Y Tsubono, S Hisamichi

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY　32　(5)　809-814　2003/10

DOI： 10.1093/ije/dyg189 　

ISSN： 0300-5771
都市に在住する70歳以上の高齢者のソーシャルサポートと抑うつ症状との関連性 (老年精神医学雑誌)

小泉弥生, 粟田主一, 関徹, 松岡洋夫, 中谷直樹, 栗山進一, 大森芳, 寳澤篤, 辻一郎, 藤田和樹, 永富良一, 海老原覚, 荒井啓行

老年精神医学雑誌　14　(5)　629-629　2003
Publisher:
ISSN： 0915-6305
生体内酸化ストレスマーカーとしての血中8-イソプロスタンに関する記述疫学鶴ヶ谷寝たきり予防健診 (日本老年医学会雑誌)

栗山進一, 荒井啓行, 海老原覚, 松井敏史, 寳澤篤, 大森芳, 藤田和樹, 坪野吉孝, 佐々木英忠, 辻一郎

日本老年医学会雑誌　40　(Suppl.)　137-137　2003
Publisher:
ISSN： 0300-9173
Medical care expenditure associated with body mass index in Japan: the Ohsaki Study Peer-reviewed

S Kuriyama, Tsuji, I, T Ohkubo, Y Anzai, K Takahashi, Y Watanabe, Y Nishino, S Hisamichi

INTERNATIONAL JOURNAL OF OBESITY　26　(8)　1069-1074　2002/08

DOI： 10.1038/sj.ijo/0802021 　

ISSN： 0307-0565
'Pyridoxine treatment in a subgroup of children with pervasive developmental disorders' Peer-reviewed

S Kuriyama, M Kamiyama, MD Watanabe, S Tamahashi, Muraguchi, I, T Watanabe, A Hozawa, T Ohkubo, Y Nishino, Y Tsubono, Tsuji, I, S Hisamichi

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY　44　(4)　284-286　2002/04

ISSN： 0012-1622

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Misc. 305

DNA Methylation Reference Panel by Gestational Age in Umbilical Cord Blood.

Hirotaka Hamada, Komaki Shohei, Ohmomo Hideki, Kuriyama Shinichi, Sugawara Junichi, Saito Masatoshi, Shimizu Atsushi

REPRODUCTIVE SCIENCES　31　225A-225A　2024/03

ISSN： 1933-7191

eISSN： 1933-7205
父母と小児の眼科的検査値の関連:三世代コホート調査

石黒真美, 小原拓, 野田あおい, 篠田元気, 大類真嗣, 宇留野晃, 吉田清香, 高田菜生子, 藤岡俊亮, 西村尭幸, 中澤徹, 布施昇男, 布施昇男, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　34th　2024
[Secondary Publication] 本邦の嚥下障害患者における,咽喉頭感覚評価法に関するアンケート調査

神林友紀, 加藤健吾, 池田怜吉, 鈴木淳, 本藏陽平, 平野愛, 太田淳, 加賀谷斉, 井上誠, 兵頭政光, 大森孝一, 末廣篤, 岡崎達馬, 出江紳一, 小山重人, 佐々木啓一, 熊井良彦, 二藤隆春, 栗山進一, 小川武則, 香取幸夫

日本耳鼻咽喉科頭頸部外科学会会報　126　(3)　243-244　2023/03
Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会
ISSN： 2436-5793

eISSN： 2436-5866
東北メディカル・メガバンク計画三世代コホート調査の進捗と今後の計画

石黒真美, 小原拓, 村上慶子, 上野史彦, 野田あおい, 大沼ともみ, 松崎芙実子, 目時弘仁, 菊谷昌浩, 菅原準一, 中谷直樹, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　117-117　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
大規模観察研究におけるランダム男女ペア間の循環代謝リスク因子の類似性の検討

中谷直樹, 中谷久美, 土屋菜歩, 曽根稔雅, 小暮真奈, 畑中里衣子, 菅野郁美, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

Journal of Epidemiology　33　(Suppl.1)　173-173　2023/02
Publisher: (一社)日本疫学会
ISSN： 0917-5040

eISSN： 1349-9092
自然災害下での精神的負担と不調—Mental burden and disorders under post-disaster settings of natural disasters—特集災害・戦争と精神科

富田博秋, 國井泰人, 濱家由美子, 日野瑞城, 栗山進一

精神科 = Psychiatry / 精神科編集委員会編　42　(2)　261-268　2023/02

ISSN： 1347-4790
Mental burden and disorders under post-disaster settings of natural disasters.

富田博秋, 富田博秋, 國井泰人, 濱家由美子, 日野瑞城, 栗山進一

月刊精神科　42　(2)　2023

ISSN： 1347-4790
TERATOGENIC RISK OF FIRST TRIMESTER EXPOSURE TO ANTIHYPERTENSIVES, INCLUDING AMLODIPINE AND METHYLDOPA: AN ANALYSIS OF AN ADMINISTRATIVE DATABASE 2010-2019

Tomofumi Ishikawa, Hidekazu Nishigori, Manabu Akazawa, Keiko Miyakoda, Aoi Noda, Mami Ishikuro, Hirohito Metoki, Noriyuki Iwama, Masatoshi Saito, Junichi Sugawara, Hiroshi Kawame, Nobuo Yaegashi, Shinichi Kuriyama, Nariyasu Mano, Taku Obara

JOURNAL OF HYPERTENSION　41　E422-E422　2023/01

ISSN： 0263-6352

eISSN： 1473-5598
魚の摂取頻度と月経痛の有病率の長期的検討エコチル調査における宮城ユニットセンター追加調査

横山絵美, 武田卓, 渡邉善, 岩間憲之, 佐藤倫広, 村上任尚, 櫻井香澄, 志賀尚美, 龍田希, 齋藤昌利, 立花眞仁, 有馬隆博, 栗山進一, 目時弘仁, 八重樫伸生

日本女性医学学会雑誌　30　(1)　125-125　2022/10
Publisher: (一社)日本女性医学学会
ISSN： 2185-8861
正常高値血圧、高値血圧における中心血圧、頸動脈内膜中膜厚と新規高血圧発症の関連

時岡紗由理, 中谷直樹, 中谷久美, 高瀬雅仁, 小暮真奈, 畑中里衣子, 菅野郁美, 千葉一平, 目時弘仁, 村上任尚, 佐藤倫広, 小原拓, 栗山進一, 寳澤篤

日本高血圧学会総会プログラム・抄録集　44回　80-80　2022/10
Publisher: (NPO)日本高血圧学会
赤ちゃんに対する気持ち質問票を用いた、母親の乳児へのマルトリートメントに対するスクリーニングの有用性

森美由紀, 西郡俊絵, 小原拓, 櫻井香澄, 鈴木妙子, 石黒真美, 龍田希, 齋藤昌利, 菅原準一, 有馬隆博, 仲井邦彦, 目時弘仁, 栗山進一, 八重樫伸生, 西郡秀和

日本周産期メンタルヘルス学会学術集会抄録集　18回　54-54　2022/10
Publisher: 日本周産期メンタルヘルス学会
年齢と骨梁面積率との関連年齢階級別の検討 ToMMo地域住民コホート調査

菅野郁美, 中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 中村智洋, 小原拓, 目時弘仁, 布施昇男, 栗山進一, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　81回　203-203　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
心血管・代謝疾患リスク要因における配偶者同士の類似性 2ヵ国バイオバンク横断研究

中谷直樹, 土屋菜歩, 成田暁, 中村智洋, 目時弘仁, 小原拓, 石黒真美, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　81回　204-204　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
妊娠中の社会的孤立と産後ボンディング障害の関連三世代コホート調査

村上慶子, 小原拓, 目時弘仁, 栗山進一

日本公衆衛生学会総会抄録集　81回　330-330　2022/09
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の進捗

中谷直樹, 小暮真奈, 畑中里衣子, 中谷久美, 千葉一平, 菅野郁美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 寳澤篤

東北公衆衛生学会誌　(71)　28-28　2022/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
母子保健情報と学校保健情報を連係した情報の活用に向けた研究三世代コホートにおける情報収集の推進

栗山進一, 小原拓, 松崎芙実子, 大沼ともみ, 野田あおい, 上野史彦, 村上慶子, 石黒真美, 小林雅幸

母子保健情報と学校保健情報を連係した情報の活用に向けた研究令和3年度総括・分担研究年度終了報告書(Web)　2022
東北メディカル・メガバンク計画・地域住民コホート調査詳細三次調査(宮城)の概要

中谷直樹, 小暮真奈, 畑中里衣子, 菅野郁美, 中谷久美, 小原拓, 中村智洋, 宇留野晃, 布施昇男, 泉陽子, 丹野高三, 辻一郎, 栗山進一, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　80回　219-219　2021/11
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
Bootstrap法およびPermutation法の応用による三世代家族の身長,体重,BMIの世代間関連の評価:三世代コホート調査

臼崎琢磨, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 野田あおい, 野田あおい, 野田あおい, 上野史彦, 上野史彦, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 小原拓, 小原拓, 小原拓, 栗山進一, 栗山進一, 栗山進一

日本衛生学雑誌(Web)　75　(Supplement)　2020

ISSN： 1882-6482
青壮中年期男性におけるヘマトクリット値の親世代との関連:三世代コホート調査

臼崎琢磨, 石黒真美, 石黒真美, 村上慶子, 村上慶子, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 野田あおい, 大柳元, 大柳元, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　30th　2020
妊婦における妊娠前からの葉酸サプリメントの摂取率および関連要因の検討:三世代コホート研究

菊池大輔, 臼崎琢磨, 大柳元, 大柳元, 米沢祐大, 米沢祐大, 山下貴宏, 山下貴宏, 村上慶子, 村上慶子, 石黒真美, 石黒真美, 上野史彦, 上野史彦, 野田あおい, 野田あおい, 目時弘仁, 目時弘仁, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 小原拓, 小原拓

日本疫学会学術総会講演集(Web)　30th　2020
家庭での受動喫煙および能動喫煙の組み合わせと高血圧の関連

平田匠, 小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 目時弘仁, 中谷直樹, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　78回　223-223　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
配偶者同士の生活習慣の一致性とその年齢の影響 ToMMo 地域住民コホート調査

中谷直樹, 土屋菜歩, 成田暁, 石黒真美, 目時弘仁, 平田匠, 小暮真奈, 中村智洋, 後岡広太郎, 中谷久美, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　78回　224-224　2019/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
三世代コホート調査参加児に対する発達評価方法の検討

小林美佳, 小林朋子, 小林朋子, 山中千鶴, 峯岸直子, 栗山進一, 呉繁夫

日本小児科学会雑誌　123　(8)　1330-1330　2019/08/01
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
小児気管支喘息の病態・疫学・診断宮城県3市町村の小児の寝具ダニアレルゲン量と真菌叢の地域性の検証

押方智也子, 渡辺麻衣子, 栗山進一, 鎌田洋一, 金子猛, 矢内勝, 呉繁夫, 釣木澤尚実

アレルギー　68　(4-5)　515-515　2019/05
Publisher: (一社)日本アレルギー学会
ISSN： 0021-4884
小児気管支喘息の病態・疫学・診断宮城県3市町村の小学生を対象としたアレルギー疾患期間有症率と寝具ダニアレルゲン量の解析

釣木澤尚実, 押方智也子, 渡辺麻衣子, 栗山進一, 嶋田貴志, 鎌田洋一, 金子猛, 矢内勝, 呉繁夫

アレルギー　68　(4-5)　515-515　2019/05
Publisher: (一社)日本アレルギー学会
ISSN： 0021-4884
一般地域住民における血清クレアチニンによる推定糸球体濾過量(eGFR)の季節差

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 宮崎真理子, 寳澤篤

日本腎臓学会誌　61　(3)　332-332　2019/05
Publisher: (一社)日本腎臓学会
ISSN： 0385-2385
東北メディカル・メガバンク計画地域住民コホート進捗と今後の展望

寳澤篤, 丹野高三, 中谷直樹, 平田匠, 瀧靖之, 栗山進一, 菅原準一, 坂田清美, 辻一郎, 呉繁夫

日本老年医学会雑誌　56　(Suppl.)　106-106　2019/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
新規リスク因子(尿ナトカリ比高値・睡眠効率不良)の高血圧への集団寄与危険割合の検討

平田匠, 平田匠, 中村智洋, 中村智洋, 小暮真奈, 小暮真奈, 宮川健, 小原拓, 小原拓, 中谷直樹, 中谷直樹, 宇留野晃, 宇留野晃, 菅原準一, 菅原準一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤

日本循環器病予防学会誌　54　(2)　121　2019/04/11

ISSN： 1346-6267
非肥満者において肝機能指標の組み合わせと糖尿病の関連は飲酒により異なるか

一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

日本循環器病予防学会誌　54　(2)　115-115　2019/04
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東北メディカル・メガバンク計画地域住民コホート調査における糖尿病研究

平田匠, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐藤衛, 菊谷昌浩, 石垣泰, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

糖尿病　62　(Suppl.1)　S-304　2019/04
Publisher: (一社)日本糖尿病学会
ISSN： 0021-437X
東日本大震災による津波避難訓練の有効性

中谷直樹, 根本晴美, YI Carine J, 佐藤文子, 新宮古都美, 庄子朋香, 佐藤翔輔, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 菅原由美, 兪志前, GUNAWANSA Nicole, 栗山進一, 村尾修, 佐藤健, 今村文彦, 富田博秋

宮城県公衆衛生学会会誌　(51)　12　2019/03

ISSN： 0912-747X
東北メディカル・メガバンク機構地域住民コホート調査詳細二次調査

寳澤篤, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫

宮城県公衆衛生学会会誌　(51)　17-17　2019/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
我が国の小児を対象とした大規模バイオバンクとコホート研究東北メディカル・メガバンクの三世代コホート調査の概要と収集試料・データの利活用

栗山進一, 小原拓, 石黒真美, 呉繁夫

日本小児科学会雑誌　123　(2)　159-159　2019/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
東日本大震災による家屋損壊程度と過敏性腸症候群の関連

永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

日本疫学会学術総会講演集(Web)　29th　149 (WEB ONLY)　2019/01/30
配偶者の主観的健康観と自身の抑うつ症状との関連:東北メディカル・メガバンク計画・地域住民コホート調査

中谷直樹, 土屋菜歩, 中谷久美, 成田暁, 平田匠, 中村智洋, 小暮真奈, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019/01/30
非肥満者における肝機能指標の組み合わせと糖尿病の関連

一迫芙美, 平田匠, 土屋菜歩, 中村智洋, 成田暁, 小暮真奈, 中谷直樹, 栗山進一, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　151 (WEB ONLY)　2019/01/30
夫婦間のメタボリック症候群及び構成因子の共有度:東北メディカル・メガバンク計画―地域住民コホート調査

土屋菜歩, 橋本航, 中谷直樹, 中村智洋, 平田匠, 成田暁, 小暮真奈, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　154 (WEB ONLY)　2019/01/30
遺伝因子と飲酒量の交互作用と随時血圧値の関連―東北メディカル・メガバンク計画地域住民コホート調査―

成田暁, 中谷直樹, 小暮真奈, 田宮元, 中村智洋, 土屋菜歩, 平田匠, 丹野高三, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　29th　147 (WEB ONLY)　2019/01/30
東日本大震災後の岩手県における社会的孤立の変化とその関連要因―地域住民コホート調査―

事崎由佳, 丹野高三, 佐々木亮平, 高梨信之, 三上貴浩, 寳澤篤, 栗山進一, 辻一郎, 大塚耕太郎, 佐藤衛, 大桃秀樹, 清水厚志, 人見次郎, 坂田清美, 佐々木真理

日本疫学会学術総会講演集(Web)　29th　122 (WEB ONLY)　2019/01/30
東日本大震災後に発生した小児への健康被害への対応に関する研究震災後の肥満とアレルギー疾患への対応小児肥満への健康教育を取り入れた効果的な介入方法の確立

栗山進一, 西出朱美, 永井雅人, 松原博子, 藤原幾磨

東日本大震災後に発生した小児への健康被害への対応に関する研究平成30年度総括・分担研究報告書(Web)　2019
次世代型プロテオミクスによる妊娠高血圧腎症の診断マーカーの同定

樋口友也, 内田康雄, 内田康雄, 加賀美智史, 城田松之, 城田松之, 三枝大輔, 三枝大輔, 小柴生造, 小柴生造, 栗山進一, 栗山進一, 菅原準一, 菅原準一, 寺崎哲也, 寺崎哲也

日本薬学会東北支部大会講演要旨集　58th　2019
Antihypertensives Prescribed for Pregnant Women in Japan: Prevalence and Timing Determined from a Database of Health Insurance Claims

Tomofumi Ishikawa, Taku Obara, Hidekazu Nishigori, Keiko Miyakoda, Mami Ishikuro, Hirohito Metoki, Takayoshi Ohkubo, Junichi Sugawara, Nobuo Yaegashi, Manabu Akazawa, Shinichi Kuriyama, Nariyasu Mano

Drug Safety　41　(11)　1168-1169　2018/11
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s40264-018-0719-2 　
妊娠高血圧症候群(HDP)患者の病態分類のためのフェノタイピングアルゴリズムの開発

水野聖士, 和形麻衣子, 永家聖, 田宮元, 栗山進一, 八重樫伸生, 菅原準一, 荻島創一

日本妊娠高血圧学会雑誌　25　94-94　2018/11
Publisher: 日本妊娠高血圧学会
ISSN： 1880-3172
妊娠期間中の飲酒と妊娠高血圧症候群リスクとの関連

岩間憲之, 田中宏典, 目時弘仁, 西郡秀和, 水野聖士, 高橋史郎, 渡邉善, 齋藤昌利, 櫻井香澄, 石黒真美, 小原拓, 龍田希, 西島維知子, 杉山隆, 藤原幾磨, 栗山進一, 有馬隆博, 仲井邦彦, 八重樫伸生

日本妊娠高血圧学会雑誌　25　109-109　2018/11
Publisher: 日本妊娠高血圧学会
ISSN： 1880-3172
被災地における児童小児の心理的特徴

坂間玲子, 横川博英, 藤林和俊, 内藤俊夫, 佐藤ゆき, 山中千鶴, 菊谷昌浩, 宮下真子, 栗山進一

日本公衆衛生学会総会抄録集　77回　329-329　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
レセプトデータベースに基づく妊娠前、妊娠中、および出産後の抗てんかん薬処方状況の評価

石川智史, 小原拓, 神一敬, 西郡秀和, 都田桂子, 鈴鹿雅人, 赤沢学, 中里信和, 八重樫伸生, 栗山進一, 眞野成康

日本薬剤疫学会学術総会抄録集　24回　98-98　2018/10
Publisher: (一社)日本薬剤疫学会
レセプトデータベースに基づく妊娠前、妊娠中、および出産後の抗てんかん薬処方状況の評価

石川智史, 小原拓, 神一敬, 西郡秀和, 都田桂子, 鈴鹿雅人, 赤沢学, 中里信和, 八重樫伸生, 栗山進一, 眞野成康

日本薬剤疫学会学術総会抄録集　24回　98-98　2018/10
Publisher: (一社)日本薬剤疫学会
東日本大震災後の社会的孤立と抑うつ症状との関連 TMM CommCohort Study

事崎由佳, 丹野高三, 佐々木亮平, 高梨信之, 三上貴浩, 寳澤篤, 栗山進一, 辻一郎, 高橋宗康, 清水厚志, 人見次郎, 坂田清美

日本公衆衛生学会総会抄録集　77回　463-463　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の心理的苦痛有病割合の推移地域住民コホート調査

丹野高三, 佐々木亮平, 高梨信之, 事崎由佳, 三上貴浩, 高橋宗康, 寳澤篤, 栗山進一, 辻一郎, 清水厚志, 人見次郎, 坂田清美

日本公衆衛生学会総会抄録集　77回　506-506　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地住民における平均歩数の変化地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　209-209　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
尿中ナトリウムカリウム比値と家庭血圧値の変化地域住民コホート調査

小暮真奈, 中谷直樹, 土屋菜歩, 中村智洋, 平田匠, 成田暁, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　215-215　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災の被災地住民における家庭血圧値の変化地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 平田匠, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　218-218　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後のメンタルヘルス関連指標変化と家屋被害の関連

土屋菜歩, 中村智洋, 平田匠, 成田暁, 小暮真奈, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫, 大塚耕太郎, 富田博秋, 寳澤篤

日本公衆衛生学会総会抄録集　77回　252-252　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
家屋損壊程度と骨梁面積率の変化量の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 平田匠, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　253-253　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
家屋の損壊の程度と頸動脈エコー内膜中膜肥厚の変化地域住民コホート調査

寳澤篤, 中谷久美, 平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 栗山進一, 辻一郎, 呉繁夫

日本公衆衛生学会総会抄録集　77回　345-345　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
一般住民における尿Na/K比と腎機能障害への進行の関連住民コホート調査

良知弘務, 土屋菜歩, 平田匠, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　345-345　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災に伴う家屋被害の程度とHbA1c値の変化の関連地域住民コホート調査

平田匠, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 後岡広太郎, 丹野高三, 坂田清美, 小原拓, 中谷直樹, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　77回　358-358　2018/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
疫学研究における妊婦の随時血圧と家庭血圧に関する検討三世代コホート調査

臼崎琢磨, 石黒真美, 小原拓, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 菊谷昌浩, 目時弘仁, 栗山進一

日本高血圧学会総会プログラム・抄録集　41回　YIP-09　2018/09
Publisher: (NPO)日本高血圧学会
気管支喘息病態・治療石巻市小学校2年生を対象とした寝具ダニアレルゲン環境整備指導介入の効果の検証

釣木澤尚実, 押方智也子, 渡辺麻衣子, 松原博子, 栗山進一, 嶋田貴志, 鎌田洋一, 金子猛, 矢内勝, 呉繁夫

日本小児アレルギー学会誌　32　(3)　512-512　2018/08
Publisher: 日本小児アレルギー学会
ISSN： 0914-2649
環境整備指導における自己成長エゴグラムの活用

押方智也子, 渡辺麻衣子, 松原博子, 栗山進一, 嶋田貴志, 鎌田洋一, 金子猛, 矢内勝, 呉繁夫, 釣木澤尚実

日本小児アレルギー学会誌　32　(3)　616-616　2018/08
Publisher: 日本小児アレルギー学会
ISSN： 0914-2649
身長、体重、BMIの世代間の関連三世代コホート調査

臼崎琢磨, 石黒真美, 小原拓, 山中千鶴, 永井雅人, 松原博子, 菊谷昌浩, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(67)　35-35　2018/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
単日および複数日測定による尿ナトカリ比値と高血圧有病率との関連東北メディカル・メガバンク計画コホート調査の成果から

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 宮川健, 栗山進一, 菅原準一, 菊谷昌浩, 寳澤篤

日本循環器病予防学会誌　53　(2)　181-181　2018/05
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
胎児発育不全の母体背景因子についての検討前向きコホート調査

宮原周子, 石黒真美, 武山陽一, 吉永浩介, 目時弘仁, 八重樫伸生, 栗山進一

周産期医学　48　(5)　615-619　2018/05
Publisher: 東京医学社
ISSN： 0386-9881
頸動脈IMTの男女差はそのリスクファクターの集積数の分布で一部説明できる

木皿楓子, 高井貴子, 菊谷昌浩, 目時弘仁, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本循環器病予防学会誌　53　(2)　183-183　2018/05
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
石巻市小学校2年生を対象とした環境整備指導介入の効果

釣木澤尚実, 押方智也子, 渡辺麻衣子, 松原博子, 矢内勝, 鎌田洋一, 栗山進一, 呉繁夫

アレルギー　67　(4-5)　605-605　2018/05
Publisher: (一社)日本アレルギー学会
ISSN： 0021-4884
Estimating frequency of pathogenic variants in a Japanese population by using the whole-genome reference panel of ToMMo

Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko N. Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, Kengo Kinoshita, Masayuki Yamamoto

HUMAN GENOMICS　12　2018/03

ISSN： 1473-9542

eISSN： 1479-7364
周辺施設へのアクセシビリティと産後うつとの関連三世代コホート調査

永井雅人, 水野聖士, 石黒真美, 宮下真子, 山中千鶴, 佐藤ゆき, 松原博子, 小原拓, 菊谷昌浩, 目時弘仁, 栗山進一

宮城県公衆衛生学会会誌　(50)　30-30　2018/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク地域住民コホート調査に基づく、日本人呼気一酸化窒素濃度の分布と影響因子の解析(中間報告)

山田充啓, 杉浦久敏, 布施昇男, 寳澤篤, 高井貴子, 土屋奈歩, 光根歩, 栗山進一, 山本雅之, 一ノ瀬正和

日本呼吸器学会誌　7　(増刊)　213-213　2018/03
Publisher: (一社)日本呼吸器学会
ISSN： 2186-5876
被災地における児童小児の心理的特徴

坂間玲子, 横川博英, 藤林和俊, 福島真一, 内藤俊夫, 佐藤ゆき, 山中千鶴, 菊谷昌浩, 宮下真子, 栗山進一

宮城県公衆衛生学会会誌　(50)　29-29　2018/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
サンプル間の非独立性が関連解析に及ぼす影響の予備的検討

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 田宮元, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　134 (WEB ONLY)　2018/02/01
東日本大震災後の夫婦における生活習慣の共有度についての検討

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　77 (WEB ONLY)　2018/02/01
日本茶摂取頻度と頸動脈内膜中膜肥厚の関連

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 木皿楓子, 丹野高三, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫

日本疫学会学術総会講演集(Web)　28th　116 (WEB ONLY)　2018/02/01
東日本大震災の被災者における高い平均歩数と関連する要因:地域住民コホート調査

中谷直樹, 成田暁, 土屋菜歩, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌弘, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018/02/01
周辺環境へのアクセシビリティと産後6ヶ月時点の抑うつ症状との関連:三世代コホート調査

永井雅人, 水野聖士, 小暮真奈, 石黒真美, 山中千鶴, 松原博子, 小原拓, 小原拓, 菊谷昌浩, 目時弘仁, 目時弘仁, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一, 栗山進一

日本疫学会学術総会講演集(Web)　28th　85 (WEB ONLY)　2018/02/01
東日本大震災による家屋損壊の程度とメタボリック症候群の構成要素

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　28th　137 (WEB ONLY)　2018/02/01
妊娠高血圧症候群(HDP)フェノタイピングのためのアルゴリズムの検討

水野聖士, 永家聖, 飯田渓太, 笠原直子, 田宮元, 栗山進一, 八重樫伸生, 田中博, 菅原準一, 荻島創一

日本疫学会学術総会講演集(Web)　28th　133 (WEB ONLY)　2018/02/01
東日本大震災後に発生した小児の健康被害への対応に関する研究震災後の肥満とアレルギー疾患への対応食事摂取頻度調査票を用いた小児肥満への介入方法の検討

栗山進一, 西出朱美, 松原博子, 永井雅人

東日本大震災後に発生した小児への健康被害への対応に関する研究平成29年度総括・分担研究報告書(Web)　2018
東日本大震災後に発生した小児の健康被害への対応に関する研究震災後の肥満とアレルギー疾患への対応小児肥満への健康教育を取り入れた効果的な介入方法

栗山進一, 西出朱美, 松原博子, 永井雅人

東日本大震災後に発生した小児への健康被害への対応に関する研究平成29年度総括・分担研究報告書(Web)　2018
東北メディカル・メガバンク機構が実施したコホート調査の歯科健診

小山史穂子, 相田潤, 川嶋順子, 松井裕之, 高井貴子, 小坂健, 栗山進一, 寳澤篤, 坪井明人

日本公衆衛生学会総会抄録集　76回　569-569　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
被災地域では仮設だけでなくみなし仮設居住者も食事摂取不良のリスクとなる

坪田恵, 高梨信之, 佐々木亮平, 丹野高三, 寳澤篤, 栗山進一, 辻一郎, 坂田清美

日本公衆衛生学会総会抄録集　76回　325-325　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク機構が実施したコホート調査の歯科健診

小山史穂子, 相田潤, 川嶋順子, 松井裕之, 高井貴子, 小坂健, 栗山進一, 寳澤篤, 坪井明人

日本公衆衛生学会総会抄録集　76回　569-569　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災地における運動習慣の状況 TMM CommCohort Study

高梨信之, 丹野高三, 佐々木亮平, 坪田恵, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　76回　603-603　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災地における社会的孤立の状況 TMM CommCohort Study

佐々木亮平, 丹野高三, 高梨信之, 坪田恵, 宇津木, 坂田清美, 寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　76回　603-603　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
宮城県内における母親の出産後再喫煙の状況エコチル調査のデータから

西浜柚季子, 龍田希, 櫻井香澄, 仲井邦彦, 栗山進一, 目時弘仁, 八重樫伸生

日本公衆衛生学会総会抄録集　76回　442-442　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査における参加者のAQについて

山中千鶴, 中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 菊谷昌浩, 石黒真美, 菅原準一, 辻一郎, 呉繁夫, 寳澤篤, 栗山進一

日本公衆衛生学会総会抄録集　76回　285-285　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画における地域住民コホート調査の詳細二次調査の概要

寳澤篤, 丹野高三, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菊谷昌浩, 目時弘仁, 坂田清美, 菅原準一, 栗山進一, 辻一郎, 中村元行, 呉繁夫

日本公衆衛生学会総会抄録集　76回　287-287　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の地域住民における腎機能と関連因子

土屋菜歩, 清元秀泰, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　290-290　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
尿中ナトリウムカリウム比と高血圧有病リスクとの関連地域住民コホート調査

小暮真奈, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 清元秀泰, 菊谷昌浩, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　291-291　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の家屋損壊程度と体脂肪率の関連地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　292-292　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査における年齢別の中心血圧分布

菊谷昌浩, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 目時弘仁, 小原拓, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　293-293　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
頸動脈IMTとリスク因子の関連東北メディカル・メガバンク計画地域住民コホート調査

木皿楓子, 土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 高井貴子, 菊谷昌浩, 目時弘仁, 丹野高三, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　293-293　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
性・年齢階級別にみた家族との同居状況と心理的苦痛の関連地域住民コホート調査

及川真紀, 佐藤喜根子, 佐藤眞理, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 富田博秋, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　315-315　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
地域住民コホート調査における家屋の被害の程度と平均歩数の関連

中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　325-325　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンクにおける過敏性腸症候群の有病割合地域住民コホート調査

永家聖, 中谷直樹, 田中由佳里, 金澤素, 荻島創一, 高井貴子, 中村智洋, 土屋菜歩, 成田暁, 栗山進一, 田中博, 辻一郎, 呉繁夫, 寳澤篤, 福土審

日本公衆衛生学会総会抄録集　76回　395-395　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災による家屋の被災状況と骨密度の関連東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　76回　409-409　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク計画地域住民コホート調査における参加者の筋力について

永井雅人, 土屋菜歩, 菊谷昌浩, 中谷直樹, 成田暁, 中村智洋, 小暮真奈, 丹野高三, 坂田清美, 菅原準一, 辻一郎, 呉繁夫, 栗山進一, 寳澤篤

日本公衆衛生学会総会抄録集　76回　652-652　2017/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
石巻市小学校2年生のアレルギー疾患有症率と寝具ダニ・真菌アレルゲン調査

押方智也子, 渡辺麻衣子, 山田敦子, 松原博子, 矢内勝, 鎌田洋一, 栗山進一, 呉繁夫, 釣木澤尚実

日本小児アレルギー学会誌　31　(4)　562-562　2017/10
Publisher: 日本小児アレルギー学会
ISSN： 0914-2649
母体出生体重と妊娠高血圧症候群の関連三世代コホート調査での検討

和形麻衣子, 土屋菜歩, 中谷直樹, 目時弘仁, 寳澤篤, 栗山進一, 八重樫伸生, 菅原準一

日本妊娠高血圧学会雑誌　24　58-58　2017/09
Publisher: 日本妊娠高血圧学会
ISSN： 1880-3172
国内地方都市における緑地環境指標と幼児の既往症に関する予備的研究

大場真, 佐藤ゆき, Ng Chris Fook Sheng, 林希一郎, 栗山進一

東北公衆衛生学会誌　(66)　35-35　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

宮下真子, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 佐藤ゆき, 石黒真美, 小原拓, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(66)　31-31　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
東日本大震災後の小児の気管支喘息とアトピー性皮膚炎の再発・悪化

宮下真子, 菊谷昌浩, 山中千鶴, 水野聖士, 永井雅人, 松原博子, 佐藤ゆき, 石黒真美, 小原拓, 目時弘仁, 栗山進一

東北公衆衛生学会誌　(66)　31-31　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
母親の出産後再喫煙の状況宮城県におけるエコチル調査結果から

西浜柚季子, 龍田希, 櫻井香澄, 仲井邦彦, 栗山進一, 目時弘仁, 藤原幾磨, 有馬隆博, 八重樫伸生

東北公衆衛生学会誌　(66)　34-34　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
性・年齢階級別にみた東日本大震災後の平均歩数地域住民コホート調査

中谷直樹, 成田暁, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 坂田清美, 菊谷昌浩, 高井貴子, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

東北公衆衛生学会誌　(66)　29-29　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
性・年齢別に見た東日本大震災後の地域住民における腎機能と頸動脈内膜中膜複合体厚の関連

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 菊谷昌浩, 丹野高三, 菅原準一, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

東北公衆衛生学会誌　(66)　30-30　2017/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
石巻市小学校2年生のアレルギー疾患の期間有症率と震災後の環境および寝具ダニアレルゲン調査

釣木澤尚実, 押方智也子, 山田敦子, 松原博子, 栗山進一, 呉繁夫, 鎌田洋一, 矢内勝, 渡辺麻衣子

日本職業・環境アレルギー学会雑誌　25　(1)　56-56　2017/06
Publisher: 日本職業・環境アレルギー学会
ISSN： 1349-5461
「遺伝の仕組み」と「多様性」を学ぶための小児を対象とした遺伝教育ツール開発の取り組み

小林朋子, 菅原美智子, 石原利乃, 本郷一夫, 相澤弥生, 山口由美, 齋藤さかえ, 田中由佳里, 栗木美穂, 長神風二, 安田純, 栗山進一, 川目裕, 山本雅之, 鈴木洋一

日本遺伝カウンセリング学会誌　38　(2)　89-89　2017/05
Publisher: 日本遺伝カウンセリング学会
ISSN： 1347-9628
気管支喘息(小児) 疫学・病態石巻市小学校2年生における小児アレルギー疾患の有症率調査

釣木澤尚実, 押方智也子, 渡辺麻衣子, 山田敦子, 松原博子, 栗山進一, 呉繁夫

アレルギー　66　(4-5)　586-586　2017/05
Publisher: (一社)日本アレルギー学会
ISSN： 0021-4884
空間情報を用いた都市部緑地配置と幼児の既往症に関する研究

大場真, 佐藤ゆき, Ng Chris Fook Sheng, 林希一郎, 栗山進一

宮城県公衆衛生学会会誌　(49)　19-19　2017/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災後の宮城県における小中学生の気管支喘息と湿疹の有症率について東北大学東北メディカル・メガバンク機構地域子ども長期健康調査より

宮下真子, 菊谷昌浩, 田中彰二, 山中千鶴, 佐藤ゆき, 水野聖士, 石黒真美, 小原拓, 目時弘仁, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(49)　14-14　2017/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域住民コホート(宮城県)の進捗とこれまでの成果で見えてきたこと

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菊谷昌浩, 小原拓, 石黒真美, 佐藤ゆき, 山中千鶴, 宮下真子, 目時弘仁, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(49)　17-17　2017/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災後の保育所園児における過体重の発症被災地の子どもの発育状況等に関する全国調査

菊谷昌浩, 松原博子, 石黒真美, 佐藤ゆき, 小原拓, 目時弘仁, 磯島豪, 横谷進, 加藤則子, 田中敏章, 千田勝一, 小野敦史, 細矢光亮, 横道洋司, 山縣然太朗, 田中総一郎, 呉繁夫, 栗山進一

宮城県公衆衛生学会会誌　(49)　15-15　2017/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
自宅から最寄駅までの距離とBody Mass Indexの関連震災後の住居による層別化解析

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 栗山進一, 菅原準一, 呉繁夫, 辻一郎, 寳澤篤

宮城県公衆衛生学会会誌　(49)　18-18　2017/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東日本大震災後の沿岸部と内陸部の慢性疾患の治療中断割合の比較

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　100 (WEB ONLY)　2017/01/25
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　103 (WEB ONLY)　2017/01/25
東日本大震災後における自宅から最寄駅までの距離とBMIの関連は食事パターンで説明できるか

小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　88 (WEB ONLY)　2017/01/25
東日本大震災後の内陸部と沿岸部の胃がんリスク比較

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫

日本疫学会学術総会講演集(Web)　27th　130 (WEB ONLY)　2017/01/25
東日本大震災後のメンタルヘルスの内陸‐沿岸較差:東北メディカル・メガバンク事業

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 冨田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本疫学会学術総会講演集(Web)　27th　126 (WEB ONLY)　2017/01/25
三世代コホート調査における調査票結果回付における情報管理について

永家聖, 永家聖, 下川和郎, 佐藤ゆき, 石黒真美, 水野聖士, 宮下真子, 山中千鶴, 目時弘仁, 荻島創一, 高井貴子, 栗山進一, 田中博

日本疫学会学術総会講演集(Web)　27th　116 (WEB ONLY)　2017/01/25
「遺伝の仕組み」と「多様性」を学ぶための小児を対象とした遺伝教育ツール開発の取り組み

小林朋子, 小林朋子, 菅原美智子, 石原利乃, 本郷一夫, 相澤弥生, 山口由美, 齋藤さかえ, 田中由佳里, 栗木美穂, 長神風二, 安田純, 櫻井美佳, 栗山進一, 川目裕, 鈴木吉也, 山本雅之, 鈴木洋一, 鈴木洋一

日本人類遺伝学会大会プログラム・抄録集　62nd　324　2017
バースコホート研究から何が明らかになるのか? 三世代コホート調査の内容と目的、進捗状況について

目時弘仁, 栗山進一

日本新生児成育医学会雑誌　28　(3)　444-444　2016/11
Publisher: (一社)日本新生児成育医学会
ISSN： 2189-7549
東北メディカル・メガバンク事業地域住民コホート調査の詳細とドルーゼン解析調査

本間慶, 布施昇男, 高井貴子, 清元秀泰, 菅原純一, 鈴木洋一, 菊谷昌浩, 栗山進一, 寳澤篤, 八重樫伸生, 呉繁夫, 山本雅之

眼科臨床紀要　9　(11)　926-926　2016/11
Publisher: 眼科臨床紀要会
ISSN： 1882-5176
検体採取のタイミングによる随時尿中Na/K比の検討 TMM CommCohort Study

丹野高三, 佐々木亮平, 高梨信之, 坂田清美, 寳澤篤, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　75回　424-424　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災被災状況とうつ病及びPTSD罹患リスクとの関連

高梨信之, 丹野高三, 佐々木亮平, 大塚耕太郎, 坂田清美, 中谷直樹, 寳澤篤, 栗山進一, 辻一郎, 中村元行, 人見次郎

日本公衆衛生学会総会抄録集　75回　579-579　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の自宅から最寄駅までの距離と高血圧治療中断に関する地理疫学的検討

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　253-253　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の身体活動量とこころの健康の関連地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　288-288　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
沿岸部居住者における東日本大震災後の新規うつ病・PTSD罹患リスク

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 菊谷昌浩, 菅原準一, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

日本公衆衛生学会総会抄録集　75回　303-303　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の現在の居住地と食事パターンの関連地域住民コホート調査

小暮真奈, 成田暁, 土屋菜歩, 中村智洋, 中谷直樹, 丹野高三, 坂田清美, 島津太一, 菊谷昌浩, 菅原準一, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本公衆衛生学会総会抄録集　75回　304-304　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東北メディカル・メガバンク事業地域住民コホート調査の進捗について

寳澤篤, 丹野高三, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 佐々木亮平, 高梨信之, 坂田清美, 菅原準一, 栗山進一, 中村元行, 呉繁夫, 辻一郎

日本公衆衛生学会総会抄録集　75回　381-381　2016/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
保育園児の成長の季節性変動

磯島豪, 加藤則子, 横谷進, 田中敏章, 小野敦史, 横道洋司, 山縣然太郎, 田中総一郎, 松原博子, 石黒真美, 菊谷昌浩, 千田勝一, 細谷光亮, 栗山進一, 呉繁夫

日本成長学会雑誌　22　(2)　106-106　2016/09
Publisher: 日本成長学会
ISSN： 1880-022X
福島県における東日本大震災がもたらした乳幼児期の発育への影響

小野敦史, 細矢光亮, 磯島豪, 横谷進, 加藤則子, 田中敏章, 山縣然太朗, 千田勝一, 松原博子, 田中総一郎, 栗山進一, 菊谷昌浩, 呉繁夫

日本小児科学会雑誌　120　(5)　918-918　2016/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
肥満幼児における体重夏増加に関する検討

加藤則子, 磯島豪, 横谷進, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

小児保健研究　75　(講演集)　195-195　2016/05
Publisher: (公社)日本小児保健協会
ISSN： 0037-4113
自宅から最寄駅までの距離と歩行習慣及びBody Mass Indexの関連東北メディカル・メガバンク事業地域住民コホート調査

土屋菜歩, 中谷直樹, 中村智洋, 成田暁, 清元秀泰, 栗山進一, 呉繁夫, 辻一郎, 寳澤篤

日本循環器病予防学会誌　51　(2)　124-124　2016/05
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災後の宮城県沿岸部における治療中断東北メディカル・メガバンク事業地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 中谷純, 峯岸直子, 布施昇男, 鈴木洋一, 菅原準一, 菊谷昌浩, 富田博秋, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

宮城県公衆衛生学会会誌　(48)　11-11　2016/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
三世代コホート調査の進捗について

目時弘仁, 石黒真美, 小原拓, 佐藤ゆき, 菊谷昌浩, 栗山進一, 寳澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 冨永悌二, 布施昇男, 峯岸直子, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

宮城県公衆衛生学会会誌　(48)　10-10　2016/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域住民コホート調査における眼軸長検査

布施昇男, 本間慶, 高井貴子, 荻島創一, 清元秀泰, 菅原準一, 鈴木洋一, 菊谷昌浩, 栗山進一, 寳澤篤, 八重樫伸生, 呉繁夫, 山本雅之

日本眼科学会雑誌　120　(臨増)　200-200　2016/03
Publisher: (公財)日本眼科学会
ISSN： 0029-0203
随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016/01/21

ISSN： 1349-9092
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016/01/21

ISSN： 1349-9092
三世代コホート調査の進捗と子どもの父母の質問票

目時弘仁, 石黒真美, 石黒真美, 小原拓, 小原拓, 佐藤ゆき, 水野聖士, 水野聖士, 宮下真子, 宮下真子, 菊谷昌浩, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 寳澤篤, 寳澤篤, 大隅典子, 大隅典子, 清元秀泰, 清元秀泰, 菅原準一, 菅原準一, 鈴木洋一, 鈴木洋一, 冨永悌二, 冨永悌二, 布施昇男, 布施昇男, 峯岸直子, 峯岸直子, 辻一郎, 辻一郎, 呉繁夫, 呉繁夫, 八重樫伸生, 八重樫伸生, 山本雅之, 山本雅之

Journal of Epidemiology (Web)　26　(Supplement 1)　105　2016/01/21

ISSN： 1349-9092
随時尿Na/K比,随時尿からの推定食塩摂取量と血圧値の相関について―東北メディカル・メガバンク事業―

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小暮真奈, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 荻島創一, 高井貴子, 峯岸直子, 栗山進一, 辻一郎, 呉繁夫, 丹野高三, 佐々木亮平, 坂田清美

Journal of Epidemiology (Web)　26　(Supplement 1)　123　2016/01/21

ISSN： 0917-5040
東日本大震災後の宮城県におけるメタボリック症候群の規定要因:地域住民コホート調査

中村智洋, 中谷直樹, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 高井貴子, 荻島創一, 峯岸直子, 清元秀泰, 鈴木洋一, 菅原準一, 布施昇男, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 寳澤篤

Journal of Epidemiology (Web)　26　(Supplement 1)　124　2016/01/21

ISSN： 0917-5040
マタニティログ調査:ヘルスケアデータと多層オミックスデータによる妊娠関連疾患の予防・早期発見に向けたコホート調査

原田祐希, 越智大介, 山内隆史, 山下理宇, 高井貴子, 荻島創一, 峯岸直子, 田邉修, 田邉修, 栗山進一, 栗山進一, 布施昇男, 八重樫伸生, 八重樫伸生, 山本雅之, 山本雅之, 檜山聡, 長崎正朗, 菅原準一, 菅原準一

日本分子生物学会年会プログラム・要旨集(Web)　39th　ROMBUNNO.3LBA‐096 (WEB ONLY)　2016
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の宮城県における歯科受診状況と関連因子についての検討

土屋菜歩, 坪井明人, 白石成, 中谷直樹, 中村智洋, 成田暁, 小暮真奈, 鈴木洋一, 菊谷昌浩, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　261-261　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
保育所入所児におけるBMIリバウンド時期別の体格推移に関する検討

加藤則子, 磯島豪, 横谷進, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

日本成長学会雑誌　21　(2)　93-93　2015/10
Publisher: 日本成長学会
ISSN： 1880-022X
乳幼児期の身長SDスコアの変化

田中敏章, 磯島豪, 横谷進, 加藤則子, 山縣然太朗, 横道洋司, 田中総一郎, 呉繁夫, 松原博子, 小原拓, 石黒真美, 佐藤ゆき, 目時裕仁, 菊谷昌浩, 栗山進一, 千田勝一, 小野敦史, 細谷光亮

日本成長学会雑誌　21　(2)　94-94　2015/10
Publisher: 日本成長学会
ISSN： 1880-022X
東北メディカル・メガバンク地域住民コホート調査(宮城)における高血圧の規定要因

寳澤篤, 清元秀泰, 中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 小原拓, 目時弘仁, 丹野高三, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之

日本公衆衛生学会総会抄録集　74回　260-260　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の高血圧の治療中断と関連する要因地域住民コホート調査

中谷直樹, 中村智洋, 土屋菜歩, 成田暁, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 菊谷昌浩, 清元秀泰, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　261-261　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
宮城県地域住民における心理的苦痛と喫煙行動の関連についての検討

成田暁, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤

日本公衆衛生学会総会抄録集　74回　296-296　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
東日本大震災後の睡眠薬服用開始に関連する規定要因の検討地域住民コホート調査

中村智洋, 富田博秋, 中谷直樹, 土屋菜歩, 成田暁, 中谷純, 菊谷昌浩, 栗山進一, 辻一郎, 呉繁夫, 山本雅之, 寳澤篤, 丹野高三, 佐々木亮平, 坂田清美

日本公衆衛生学会総会抄録集　74回　296-296　2015/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
不妊症既往と妊娠中の血圧との関連

石黒真美, 小原拓, 目時弘仁, 菊谷昌浩, 栗山進一, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　38回　406-406　2015/10
Publisher: (NPO)日本高血圧学会
日本人全ゲノムファレンスパネルの構築と今後

日本遺伝学会大会プログラム・予稿集　87th　73　2015/09
東北メディカル・メガバンク事業-地域住民コホート調査のデザインと経過報告(眼圧検査)

布施昇男, 本間慶, 高井貴子, 清元秀泰, 菅原準一, 鈴木洋一, 菊谷昌浩, 栗山進一, 寳澤篤, 八重樫伸生, 山本雅之

日本緑内障学会抄録集　26回　130-130　2015/09
Publisher: 日本緑内障学会
岩手県被災地域住民の随時尿中ナトリウム/カリウム濃度比東北メディカル・メガバンク地域住民コホート研究ベースライン調査

丹野高三, 佐々木亮平, 坂田清美, 寳澤篤, 栗山進一, 辻一郎, 遠藤龍人, 小林誠一郎, 八谷剛史, 佐藤衛, 小笠原邦昭, 中村元行, 人見次郎, 祖父江憲治

日本循環器病予防学会誌　50　(2)　136-136　2015/06
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東北メディカル・メガバンク地域住民コホート宮城エリアにおける随時尿Na/K比の内陸部・沿岸部比較

寳澤篤, 中谷直樹, 中村智洋, 土屋菜歩, 小暮真奈, 丹野高三, 佐々木亮平, 坂田清美, 中谷純, 峯岸直子, 清元秀泰, 菅原準一, 布施昇男, 菊谷昌浩, 鈴木洋一, 富田博秋, 栗山進一, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

日本循環器病予防学会誌　50　(2)　126-126　2015/06
Publisher: (一社)日本循環器病予防学会
ISSN： 1346-6267
東日本大震災後の小中学生の保護者が抱く子どもの不安と悩みの特徴宮城県南部の実態調査から

佐藤ゆき, 菊谷昌浩, 宮下真子, 山中千鶴, 石黒真美, 小原拓, 目時弘仁, 土屋菜歩, 中村智洋, 中谷直樹, 寳澤篤, 辻一郎, 呉繁夫, 八重樫伸生, 栗山進一

小児保健研究　74　(講演集)　139-139　2015/05
Publisher: (公社)日本小児保健協会
ISSN： 0037-4113
全国と比較した被災3県保育所入所児童の身体発育の特徴

加藤則子, 磯島豪, 横谷進, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

小児保健研究　74　(講演集)　204-204　2015/05
Publisher: (公社)日本小児保健協会
ISSN： 0037-4113
緑茶成分摂取量と動脈硬化関連指標との関連掛川コホート研究

五十嵐祐子, 小原拓, 石黒真美, 鴫原美智子, 都田桂子, 目時弘仁, 菊谷昌浩, 栗山進一

宮城県公衆衛生学会会誌　(47)　5-5　2015/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
果物・野菜・海藻摂取とすい臓がん罹患リスク:大崎国保コホート研究

SHIGIHARA MICHIKO, OHARA TAKU, NAGAI MASATO, SUGAHARA YUMI, WATANABE TAKASHI, KAKIZAKI MASAKO, NISHINO YOSHIKAZU, KURIYAMA SHIN'ICHI, TSUJI ICHIRO

宮城県公衆衛生学会会誌　(47)　6-6　2015/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
乳がん検診ランダム化比較試験参加者によるインフォームドコンセントの評価

成川洋子, 鄭迎芳, 菊谷昌浩, 河合賢朗, 石田孝宣, 鈴木昭彦, 栗山進一, 大内憲明

宮城県公衆衛生学会会誌　(47)　8-8　2015/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
全国と比較した被災3県保育所入所児童の身体発育の特徴

加藤則子, 磯島豪, 横谷進, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

日本衛生学雑誌　70　(Suppl.)　S190-S190　2015/03
Publisher: (一社)日本衛生学会
ISSN： 0021-5082
Blood Pressure and Heart Rate Among Pregnant Women Before and After the Great East Japan Earthquake (11, March, 2011) in the BOSHI Study. Peer-reviewed

Metoki Hirohito, Iwama Noriyuki, Watanabe Zen, Ohkubo Takayoshi, Ishikuro Mami, Obara Taku, Kikuya Masahiro, Sugawara Junichi, Kuriyama Shinichi, Itoh Kiyoshi, Hoshi Kazuhiko, Suzuki Masakuni, Satoh Michihiro, Yaegashi Nobuo, Imai Yutaka

REPRODUCTIVE SCIENCES　22　385A　2015/03

ISSN： 1933-7191
Home Blood Pressure Had a Stronger Predictive Power for Infant Birth Weight Than Clinic Blood Pressure: The Boshi Study. Peer-reviewed

Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, Ishikuro Mami, Obara Taku, Kikuya Masahiro, Yagihashi Katsuyo, Nishigori Hidekazu, Sugiyama Takashi, Sugawara Junichi, Yaegashi Nobuo, Hoshi Kazuhiko, Suzuki Masakuni, Kuriyama Shinichi, Imai Yutaka

REPRODUCTIVE SCIENCES　22　383A　2015/03

ISSN： 1933-7191
東日本大震災が福島県の乳幼児の体格に与えた影響

磯島豪, 横谷進, 小野敦史, 加藤則子, 田中敏章, 山縣然太郎, 田中総一郎, 松原博子, 栗山進一, 呉繁夫, 厚労省呉班研究班乳幼児発育評価WG

日本小児科学会雑誌　119　(2)　258-258　2015/02
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
低出生体重児の予後及び保健的介入並びに妊婦及び乳幼児の体格の疫学的調査手法に関する研究〈妊婦及び乳幼児コホート研究の手法整理〉出生前コホート研究で用いる質問票データベース開発

横山徹爾, 加藤則子, 栗山進一, 佐々木敏, 佐藤昌司, 瀧本秀美, 土屋賢治, 堀川玲子, 三宅吉博, 宮坂尚幸, 吉田穂波, 頼藤貴志, 磯島豪, 石黒真美, 峯岸直子, 目時弘仁, 大久保公美, 松田義雄, 中井章人, HTUN Nay Chi, 田中景子, 佐藤憲子

低出生体重児の予後及び保健的介入並びに妊婦及び乳幼児の体格の疫学的調査手法に関する研究平成26年度総括・分担研究報告書　85-91　2015
被災地健康調査における家庭血圧計診断に基づく高血圧症の実態

清元秀泰, 寳澤篤, 田中由香利, 奥田拓史, 菅原準一, 坪井明人, 布施昇男, 栗山進一, 瀧靖之, 辻一郎, 阿部倫明, 高井貴子, 八重樫伸生, 山本雅之, 伊藤貞嘉

日本高血圧学会総会プログラム・抄録集　37回　442-442　2014/10
Publisher: (NPO)日本高血圧学会
復興への針路復興を担う子どもたちのために東日本大震災の小児保健への影響に関する調査研究

呉繁夫, 千田勝一, 細矢光亮, 山縣然太郎, 栗山進一, 奥山眞紀子, 藤原武男, 増子博文, 本間博彰, 八木淳子

日本小児科医会会報　(48)　56-59　2014/10
Publisher: (公社)日本小児科医会
ISSN： 0912-1781

eISSN： 2435-9270
乳幼児期のBMI SDスコアと肥満度の縦断的推移

磯島豪, 横谷進, 加藤則子, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

日本成長学会雑誌　20　(2)　93-93　2014/08
Publisher: 日本成長学会
ISSN： 1880-022X
東北3県における大震災前後の幼児の体格変化

田中敏章, 磯島豪, 横谷進, 加藤則子, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

日本成長学会雑誌　20　(2)　94-94　2014/08
Publisher: 日本成長学会
ISSN： 1880-022X
被災地域を中心とした全国保育所入所児童の身体発育に関する検討

加藤則子, 磯島豪, 横谷進, 田中敏章, 山縣然太朗, 田中総一郎, 呉繁夫, 松原博子, 石黒真美, 菊谷昌浩, 栗山進一

日本成長学会雑誌　20　(2)　95-95　2014/08
Publisher: 日本成長学会
ISSN： 1880-022X
乳癌検診の評価とJ-START

石田孝宣, 鈴木昭彦, 祖父江友孝, 栗山進一, 山本精一郎, 河合賢朗, 成川洋子, 鄭迎芳, 福田護, 大内憲明

日本乳癌学会総会プログラム抄録集　22回　215-215　2014/07
Publisher: (一社)日本乳癌学会
妊娠中の医薬品使用と児の先天奇形との関連:レセプトデータに基づく検討

小原拓, 佐藤倫広, 西郡秀和, 目時弘仁, 大久保孝義, 赤沢学, 八重樫伸生, 栗山進一, 眞野成康

日本医薬品情報学会総会・学術大会講演要旨集　17th　81-81　2014/07
Publisher: (一社)日本医薬品情報学会
腎疾患個別化医療実現に向けた健常人ゲノムコホートの構築

清元秀泰, 阿部倫昭, 奥田拓史, 岡村将史, 宮崎真理子, 寳澤篤, 栗山進一, 高井貴子, 長崎正朗, 峯岸直子, 安田純, 森建文, 中谷純, 菅原準一, 八重樫伸生, 佐藤博, 山本雅之, 伊藤貞嘉

日本腎臓学会誌　56　(3)　352-352　2014/05
Publisher: (一社)日本腎臓学会
ISSN： 0385-2385
地域子ども長期健康調査のこころとからだの支援

山中千鶴, 宮下真子, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 菊谷昌浩, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(46)　4-4　2014/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
子どもの発育状況に関する研究初年度調査報告

松原博子, 菊谷昌浩, 石黒真美, 田中総一郎, 細矢光亮, 千田勝一, 栗山進一, 呉繁夫

宮城県公衆衛生学会会誌　(46)　5-5　2014/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業―三世代コホート調査に関する経過報告

目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 栗山進一, 栗山進一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 中谷直樹, 寶澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 富田博秋, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生

J Epidemiol　24　(Supplement 1)　67　2014/01/23

ISSN： 0917-5040
エコチル調査・宮城ユニットセンターにおける妊婦の医薬品使用状況の評価-宮城ユニットセンター薬剤詳細調査より-

西郡秀和, 小原拓, 目時弘仁, 石黒真美, 水野聖士, 櫻井香澄, 岩間憲之, 村井ユリ子, 杉山隆, 菅原準一, 眞野成康, 栗山進一, 八重樫伸生

DOHaD研究　3　(1)　49-49　2014
Publisher: 日本DOHaD研究会
ISSN： 2187-2597

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第3回日本DOHaD研究会学術集会抄録集【ポスター発表】
レセプトデータに基づく妊娠中の医薬品使用と児の先天奇形との関連に関する検討

小原拓, 西郡秀和, 目時弘仁, 眞野成康, 八重樫伸生, 栗山進一

DOHaD研究　3　(1)　58-58　2014
Publisher: 日本DOHaD研究会
ISSN： 2187-2597

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第3回日本DOHaD研究会学術集会抄録集【ポスター発表】
東北メディカル・メガバンク事業三世代コホート調査の進捗について

目時弘仁, 石黒真美, 小原拓, 佐藤ゆき, 菊谷昌浩, 栗山進一, 寳澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 冨永悌二, 布施昇男, 峯岸直子, 辻一郎, 呉繁夫, 八重樫伸生, 山本雅之

DOHaD研究　3　(1)　46-46　2014
Publisher: 日本DOHaD研究会
ISSN： 2187-2597

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第3回日本DOHaD研究会学術集会抄録集【ポスター発表】
The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients. International-journal

Hirota, Morihisa, Shimosegawa, Tooru, Masamune, Atsushi, Kikuta, Kazuhiro, Kume, Kiyoshi, Hamada, Shin, Kanno, Atsushi, Kimura, Kenji, Tsuji, Ichiro, Kuriyama, Shinichi, Research Committee of Intractable Pancreatic Diseases

Pancreatology　14　(6)　490-496　2014

DOI： 10.1016/j.pan.2014.08.008 　

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OBJECTIVES: A nationwide survey was conducted to clarify the epidemiological features of patients with chronic pancreatitis (CP) in Japan. METHODS: In the first survey, both the prevalence and the incidence of CP in 2011 were estimated. In the second survey, the clinicoepidemiological features of the patients were clarified by mailed questionnaires. Patients were diagnosed by the Japanese diagnostic criteria for chronic pancreatitis 2009. RESULTS: The estimated annual prevalence and incidence of CP in 2011 were 52.4/100,000 and 14.0/100,000, respectively. The sex ratio (male/female) of patients was 4.6, with a mean age of 62.3 years. Alcoholic (67.5%) was the most common and idiopathic (20.0%) was the second most common cause of CP. Comorbidity with diabetes mellitus (DM) and pancreatic calcifications (PC) occurred more frequent in ever smokers independently of their drinking status. Among patients without drinking habit, the incidences of DM and PC were significantly higher in ever smokers than in never smokers. The multiple logistic regression analysis revealed smoking was an independent factor of DM and PC in CP patients: DM, Odds ratio (OR) 1.644, 95% confidence interval (CI) 1.202 to 2.247 (P = 0.002): PC, OR 2.010, 95% CI 1.458 to 2.773 (P < 0.001). On the other hand, smoking was not identified as an independent factor for the appearance of abdominal pain by this analysis. CONCLUSION: The prevalence of Japanese patients with CP has been increasing. Smoking was identified as an independent factor related to DM and PC in Japanese CP patients.
土-9-O11-21 小児におけるインフルエンザワクチン接種の有効性評価(感染制御(その他)2,一般演題(口頭)11,再興、再考、創ろう最高の医療の未来)

小原拓, 島崎信次郎, 金子健二, 福田純, 中村泰之, 眞野成康, 栗山進一, 八木直人

日本医療薬学会年会講演要旨集　23　216-216　2013/08/28
Publisher: 日本医療薬学会
レセプトデータに基づく妊娠中の抗菌薬処方状況の把握に関する研究

堀川いずみ, 小原拓, 目時弘仁, 大久保孝義, 八重樫伸生, 眞野成康, 佐藤博, 栗山進一

日本医療薬学会年会講演要旨集　23rd　217　2013/08/28
妊婦に対する気管支喘息治療薬の処方状況の把握に関する研究

保坂実樹, 小原拓, 目時弘仁, 佐藤倫広, 大久保孝義, 八重樫伸生, 眞野成康, 栗山進一

日本医療薬学会年会講演要旨集　23rd　435　2013/08/28
治療中高血圧患者の高血圧管理における保険調剤薬局の関与:J‐HOME‐Morning研究

小原拓, 小林由香, 池田うらら, 保坂実樹, 佐藤倫広, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

日本医療薬学会年会講演要旨集　23rd　405　2013/08/28
小児の注意欠陥/多動性障害患者に対する医薬品処方

小原拓, 佐藤倫広, 村井ユリ子, 眞野成康, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　16回　131-131　2013/08
Publisher: (一社)日本医薬品情報学会
睡眠時間と総死亡・死因別死亡リスク大崎国保コホート研究

柿崎真沙子, 栗山進一, 中谷直樹, 曽根稔雅, 永井雅人, 菅原由美, 寳澤篤, 辻一郎

宮城県公衆衛生学会会誌　(45)　4-4　2013/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンク事業地域コホート計画について

寳澤篤, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 栗山進一, 辻一郎

宮城県公衆衛生学会会誌　(45)　7-7　2013/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
東北メディカル・メガバンクにおける地域子どもコホート事業について

菊谷昌浩, 石黒真美, 小原拓, 目時弘仁, 寳澤篤, 辻一郎, 栗山進一

宮城県公衆衛生学会会誌　(45)　10-10　2013/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
妊婦における薬剤の使用に関する疫学調査

小原拓, 石黒真美, 目時弘仁, 菊谷昌浩, 栗山進一, 西郡秀和, 八重樫伸生, 大久保孝義, 眞野成康

宮城県公衆衛生学会会誌　(45)　6-6　2013/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
Methodology on Study Using Administrative Data of Selective Serotonin Reuptake Inhibitors during Pregnancy and the Risk of Infants

Aiko Shono, Taku Obara, Shinichi Kuriyama, Manabu Akazawa

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　389-389　2012/08

ISSN： 1053-8569
Prescription of Drugs during Pregnancy in Japan Peer-reviewed

Obara Taku, Akazawa Manabu, Ohkubo Takayoshi, Ishikuro Mami, Metoki Hirohito, Shono Aiko, Nishigori Hidekazu, Mano Nariyasu, Yaegashi Nobuo, Kuriyama Shinichi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY　21　380　2012/08

ISSN： 1053-8569
母親の妊娠期間中血圧値と娘の妊娠期間中血圧推移の関連 BOSHI研究

目時弘仁, 星川美奈子, 大久保孝義, 八木橋香津代, 櫻井香澄, 石黒真美, 小原拓, 菊谷昌浩, 松原洋一, 森滋, 鈴木雅洲, 佐藤博, 栗山進一, 八重樫伸生, 今井潤

東北公衆衛生学会誌　(61)　41-41　2012/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
妊婦コホートにおける医薬品使用状況に関する調査方法の検討

小林由香, 小原拓, 目時弘仁, 眞野成康, 佐藤博, 今井潤, 八重樫伸生, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　15回　107-107　2012/06
Publisher: (一社)日本医薬品情報学会
レセプトデータに基づく妊娠中の医薬品使用状況の把握に関する研究

小原拓, 石黒真美, 目時弘仁, 西郡秀和, 大久保孝義, 眞野成康, 八重樫伸生, 栗山進一

日本医薬品情報学会総会・学術大会講演要旨集　15回　105-105　2012/06
Publisher: (一社)日本医薬品情報学会
コステロ症候群・CFC症候群の全国実態調査とその病態の解明に関する研究

阿部裕, 青木洋子, 栗山進一, 川目裕, 岡本伸彦, 黒澤健司, 大橋博文, 水野誠司, 緒方勤, 呉繁夫, 新堀哲也, 松原洋一

日本小児科学会雑誌　116　(5)　888-888　2012/05
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
治療中高血圧患者の高血圧管理における保険調剤薬局の関与 J-HOME-Morning研究より

小原拓, 小林由香, 池田うらら, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集　1回　101-101　2012/04
Publisher: (NPO)日本高血圧学会
妊婦における医療用医薬品の安全性に関するエビデンスの構築のための薬剤疫学研究の基盤整備および実践

栗山進一, 八重樫伸生, 眞野成康, 赤沢学, 大久保孝義, 目時弘仁, 久保田潔, 佐藤嗣道, 庄野あい子, 小原拓

厚生労働科学研究費補助金医薬品・医療機器等レギュラトリーサイエンス総合研究事業妊婦における医療用医薬品の安全性に関するエビデンスの構築のための薬剤疫学研究の基盤整備および実践（H23-医薬-一般-006）平成２３年度総括・分担研究報告書　1-11　2012/03
エネルギー摂取量の違いからみた食べる速さと肥満の関連:大崎コホート2006研究

永井雅人, 高橋誠, 栗山進一, 栗山進一, 柿崎真沙子, 遠又靖丈, 渡邉崇, 寳澤篤, 寳澤篤

J Epidemiol　22　(Supplement 1)　78　2012/01/26

ISSN： 0917-5040
介護予防サービスの効果評価に関する研究血清セレン,水酸化ビタミンDと要介護認定・死亡に関する研究—鶴ケ谷コホート研究—

辻一郎, 寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 栗山進一

介護予防サービスの効果評価に関する研究平成23年度総括・分担研究報告書　22-27　2012
初産婦・経産婦における妊娠中の外来血圧及び家庭血圧推移 BOSHI研究

石黒真美, 小原拓, 目時弘仁, 大久保孝義, 山本真実, 阿久津好美, 櫻井香澄, 岩間憲之, 片桐未希子, 八木橋香津代, 鈴木雅洲, 八重樫伸生, 栗山進一, 今井潤

日本妊娠高血圧学会雑誌　19　99-100　2012/01
Publisher: 日本妊娠高血圧学会
ISSN： 1880-3172
妊娠初期の食塩摂取量と妊娠高血圧症候群発症との関連 BOSHI研究

山本真実, 小原拓, 目時弘仁, 大久保孝義, 石黒真美, 阿久津好美, 櫻井香澄, 片桐未希子, 岩間憲之, 八木橋香津, 鈴木雅洲, 栗山進一, 八重樫伸生, 今井潤

日本妊娠高血圧学会雑誌　19　202-203　2012/01
Publisher: 日本妊娠高血圧学会
ISSN： 1880-3172
レセプトデータを用いた妊娠高血圧患者に対する降圧薬処方状況の把握

小原拓, 大久保孝義, 目時弘仁, 西郡秀和, 石黒真美, 眞野成康, 赤沢学, 八重樫伸生, 栗山進一

日本薬剤疫学会学術総会抄録集　17回　76-77　2011/11
Publisher: (一社)日本薬剤疫学会
血清イソフラボン濃度と要介護認定・死亡の関連—鶴ケ谷コホート研究—

寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 大森芳, 栗山進一, 深尾彰, 辻一郎

日本公衆衛生学会総会抄録集　70th　197　2011/10/15

ISSN： 1347-8060
高齢者における心理的苦痛と要介護認定・死亡リスクの関連:大崎コホート2006研究

渡邉崇, 柿崎真沙子, 中谷直樹, 中谷直樹, 永井雅人, 遠又靖丈, 坪谷透, 栗山進一, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　70th　276　2011/10/15

ISSN： 1347-8060
妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連 BOSHI研究

目時弘仁, 星川美奈子, 大久保孝義, 阿久津好美, 小原拓, 櫻井香澄, 片桐未希子, 岩間憲之, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　437-437　2011/10
Publisher: (NPO)日本高血圧学会
降圧治療中患者における家庭血圧日間変動の規定因子 J-HOME-Morning研究

小原拓, 石倉一樹, 菊谷昌浩, 加藤哲夫, 芝宮拓, 新木貴大, 池田うらら, 小林由香, 目時弘仁, 眞野成康, 栗山進一, 大久保孝義, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　527-527　2011/10
Publisher: (NPO)日本高血圧学会
妊婦の出生体重及び妊娠前肥満度と妊娠中の家庭血圧測定 BOSHI研究

山本真実, 佐藤友里恵, 目時弘仁, 大久保孝義, 阿久津好美, 石黒真美, 櫻井香澄, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　585-585　2011/10
Publisher: (NPO)日本高血圧学会
正常妊娠における妊娠初期ヘマトクリット(Ht)と家庭血圧推移との関連 BOSHI研究

阿久津好美, 佐々木彩乃, 目時弘仁, 大久保孝義, 小原拓, 櫻井香澄, 八木橋香津代, 菊谷昌浩, 森滋, 鈴木雅洲, 佐藤博, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

日本高血圧学会総会プログラム・抄録集　34回　585-585　2011/10
Publisher: (NPO)日本高血圧学会
【認知症学(上)-その解明と治療の最新知見-】臨床編認知症をめぐる大規模疫学研究疫学研究におけるエビデンス構築概論 (日本臨床)

栗山進一

日本臨床　69　(増刊8 認知症学(上))　575-580　2011/10
Publisher: 日本臨床社
ISSN： 0047-1852
WEIGHT CHANGE SINCE AGE 20 AND CARDIOVASCULAR DISEASE (CVD) MORTALITY: THE OHSAKI STUDY

W. T. Chou, M. Kakizaki, Y. Tomata, M. Nagai, S. Kuriyama, I. Tsuji

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH　65　A98-A99　2011/08

DOI： 10.1136/jech.2011.142976d.8 　

ISSN： 0143-005X
GAMMA-GLUTAMYLTRANSFERASE AND CANCER INCIDENCE: THE OHSAKI COHORT STUDY

T. Tsuboya, S. Kuriyama, M. Nagai, A. Hozawa, Y. Sugawara, Y. Tomata, M. Kakizaki, Y. Nishino, I. Tsuji

AMERICAN JOURNAL OF EPIDEMIOLOGY　173　S165-S165　2011/06

ISSN： 0002-9262

eISSN： 1476-6256
The association between neighborhood social capital and self-reported dentate status in elderly Japanese - The Ohsaki cohort 2006 study

Jun Aida, S. Kuriyama, K. Ohmori-Matsuda, A. Hozawa, K. Osaka, I. Tsuji

Community Dentistry and Oral Epidemiology　39　(3)　239-249　2011/06/01

DOI： 10.1111/j.1600-0528.2010.00590.x 　

ISSN： 0301-5661

eISSN： 1600-0528
ソーシャルキャピタルの地域差に関する研究

坪谷透, 栗山進一, 遠又靖丈, 中谷直樹, 大森(松田)芳, 高橋英子, 寳澤篤, 福地成, 曽根稔雅, 永井雅人, 菅原由美, 星玲奈, 柿崎真沙子, 辻一郎

宮城県公衆衛生学会会誌　(43)　11　2011/06

ISSN： 0912-747X
コステロ症候群・CFC症候群の全国実態調査とその病態に関する研究

松原洋一, 阿部裕, 新堀哲也, 黒澤健司, 岡本伸彦, 水野誠司, 大橋博文, 川目裕, 緒方勤, 呉繁夫, 栗山進一, 青木洋子

日本遺伝カウンセリング学会誌　32　(2)　76-76　2011/05
Publisher: 日本遺伝カウンセリング学会
ISSN： 1347-9628
コステロ症候群・CFC症候群の全国実態調査とその病態に関する研究

松原洋一, 阿部裕, 新堀哲也, 黒澤健司, 岡本伸彦, 水野誠司, 大橋博文, 川目裕, 緒方勤, 呉繁夫, 栗山進一, 青木洋子

家族性腫瘍　11　(2)　A76-A76　2011/05
Publisher: 日本家族性腫瘍学会
ISSN： 1346-1052
Relationship between Peripheral Arterial Disease and Incident Disability among Japanese Elderly: the Tsurugaya Project.

A. Nitta, A. Hozawa, S. Kuriyama, N. Nakaya, K. Ohmori-Matsuda, T. Sone, M. Kakizaki, N. Tomita, S. Ebihara, K. Furukawa, M. Ichiki, H. Arai, I. Tsuji

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　59　S37-S37　2011/04

ISSN： 0002-8614
授乳方法と性ホルモン関連がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

菅原由美, 柿崎真沙子, 永井雅人, 遠又靖丈, 星玲奈, 渡邊生恵, 西野善一, 栗山進一, 栗山進一, 辻一郎

J Epidemiol　21　(1 Supplement)　144　2011/01/21

ISSN： 0917-5040
成人期の体重変化と前立腺がんリスク:大崎国保コホート研究

永井雅人, 菅原由美, 周婉てい, 坪谷透, 西野善一, 柿崎真沙子, 栗山進一, 栗山進一, 辻一郎

J Epidemiol　21　(1 Supplement)　83　2011/01/21

ISSN： 0917-5040
睡眠時間と要介護認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

柿崎真沙子, 上川康貴, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一, 辻一郎

J Epidemiol　21　(1 Supplement)　106　2011/01/21

ISSN： 0917-5040
健診受診と死亡率の関連Propensity Score Matched Cohort Analysisを用いた検討

寳澤篤, 寳澤篤, 栗山進一, 栗山進一, 渡邊生恵, 柿崎真沙子, 大森芳, 曽根稔雅, 永井雅人, 菅原由美, 新田明美, 新田明美, 李強, 大久保孝義, 大久保孝義, 村上義孝, 辻一郎

J Epidemiol　21　(1 Supplement)　119　2011/01/21

ISSN： 0917-5040
ガンマグルタミン酸転移酵素(GGT)とがん罹患リスクとの関連:大崎国保コホート研究

坪谷透, 栗山進一, 栗山進一, 永井雅人, 寳澤篤, 寳澤篤, 菅原由美, 柿崎真沙子, 西野善一, 辻一郎

J Epidemiol　21　(1 Supplement)　85　2011/01/21

ISSN： 0917-5040
介護予防サービスの効果評価に関する研究血清アディポネクチンと要介護認定・死亡に関する研究—鶴ケ谷コホート研究—

辻一郎, 寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 栗山進一

介護予防サービスの効果評価に関する研究平成22年度総括・分担研究報告書　51-55　2011
介護予防サービスの効果評価に関する研究 1日の総睡眠時間,夜間睡眠時間,要介護認定の関連についての前向きコホート研究—鶴ケ谷プロジェクト—

辻一郎, 柿崎真沙子, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一

介護予防サービスの効果評価に関する研究平成22年度総括・分担研究報告書　56-60　2011
高齢者におけるNT‐Pro BNPと要介護認定の関連—鶴ケ谷コホート研究—

寶澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 大森芳, 中谷直樹, 栗山進一, 深尾彰, 辻一郎

日本高血圧学会総会プログラム・抄録集　33rd　380　2010/10/15
緑茶摂取と肝がん罹患に関する前向きコホート研究

宇井あかね, 栗山進一, 柿崎真沙子, 曽根稔雅, 中谷直樹, 大森(松田)芳, 寳澤篤, 西野善一, 辻一郎

J Epidemiol　20　(Supplement 1)　S112　2010/01/09

ISSN： 0917-5040
介護予防サービスの効果評価に関する研究 Motor Fitness Scaleと要介護発生リスクに関する前向きコホート研究-鶴ケ谷プロジェクト-

辻一郎, 栗山進一, 寳澤篤, 星真行

介護予防サービスの効果評価に関する研究平成21年度総括・分担研究報告書　2010
慢性膵炎の実態に関する全国調査

下瀬川徹, 廣田衛久, 正宗淳, 濱田晋, 木原康之, 佐藤晃彦, 木村憲治, 辻一郎, 栗山進一

厚生労働科学研究費補助金難治性疾患克服研究事業難治性膵疾患に関する調査研究平成21年度総括・分担研究報告書　135-138　2010
Impact of physical activity and performance on medical care costs among the Japanese elderly

Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R

Geriatr Gerontol Int　00　(00)　000-000　2010

DOI： 10.1111/j.1447-0594.2010.00651.x. 　
介護予防サービスの効果評価に関する研究緑茶摂取と肺炎死亡リスクに関する研究

辻一郎, 渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 寳澤篤

介護予防サービスの効果評価に関する研究平成21年度総括・分担研究報告書　59-64　2010
Adiposity, adult weight change and breast cancer risk in postmenopausal Japanese women: the Miyagi Cohort Study.

Kawai M, Minami Y, Kuriyama S, Kakizaki M, Kakugawa Y, Nishino Y, Ishida T, Fukao A, Tsuji I, Ohuchi N

Br J Cancer　103　(9)　1443-1447　2010

DOI： 10.1038/sj.bjc.6605885 　
高齢者における血圧と要介護認定の関連鶴ヶ谷コホート研究

寳澤篤, 栗山進一, 大森芳, 曽根稔雅, 新田明美, 菅原由美, 中谷直樹, 牛凱軍, 粟田主一, 辻一郎

日本高血圧学会総会プログラム・抄録集　32回　304-304　2009/10
Publisher: (NPO)日本高血圧学会
Fish consumption and the risk of colorectal cancer: The ohsaki cohort study

Y. Sugawara, S. Kuriyama, M. Kakizaki, M. Nagai, K. Ohmori-Matsuda, T. Sone, A. Hozawa, Y. Nishino, I. Tsuji

British Journal of Cancer　101　849-854　2009/09/01

DOI： 10.1038/sj.bjc.6605217 　

ISSN： 0007-0920
食行動と肥満 (宮城県公衆衛生学会会誌)

栗山進一

宮城県公衆衛生学会会誌　(41)　17-17　2009/03
緑茶摂取頻度とK6得点との関連—大崎コホート2006研究—

寳澤篤, 栗山進一, 中谷直樹, 大森芳, 柿崎真沙子, 曽根稔雅, 永井雅人, 新田明美, 菅原由美, 牛凱軍, 辻一郎

J Epidemiol　19　(1 Supplement)　210　2009/01/24

ISSN： 0917-5040
性別にみたBMIと死因別死亡リスクに関する前向きコホート研究—大崎国保コホート研究—

永井雅人, 柿崎真沙子, 栗山進一, 大森芳, 菅原由美, 曽根稔雅, 寳澤篤, 辻一郎

J Epidemiol　19　(1 Supplement)　76　2009/01/24

ISSN： 0917-5040
Motor Fitness Scaleと要介護発生・死亡リスクに関する前向きコホート研究—鶴ケ谷プロジェクト—

星真行, 星真行, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 牛凱軍, 藤田和樹, 植木章三, 芳賀博, 永富良一, 辻一郎

J Epidemiol　19　(1 Supplement)　198　2009/01/24

ISSN： 0917-5040
魚摂取と大腸がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

菅原由美, 柿崎真沙子, 栗山進一, 大森芳, 曽根稔雅, 寳澤篤, 西野善一, 辻一郎

J Epidemiol　19　(1 Supplement)　63　2009/01/24

ISSN： 0917-5040
睡眠時間と乳がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

柿崎真沙子, 柿崎真沙子, 栗山進一, 曽根稔雅, 大森芳, 寳澤篤, 中谷直樹, 福土審, 辻一郎

J Epidemiol　19　(1 Supplement)　67　2009/01/24

ISSN： 0917-5040
末梢動脈疾患と要介護発生に関する前向きコホート研究〜鶴ケ谷プロジェクト〜

新田明美, 新田明美, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 海老原覚, 市来正隆, 荒井啓行, 辻一郎

J Epidemiol　19　(1 Supplement)　199　2009/01/24

ISSN： 0917-5040
要介護認定者における要介護状態区分の推移に関する研究

曽根稔雅, 中谷直樹, 大森芳, 寳澤篤, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　67回　519-519　2008/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
JNC7分類における高血圧分類と循環器疾患死亡の関連大崎国保コホート

寳澤篤, 栗山進一, 大森芳, 大久保孝義, 辻一郎

日本高血圧学会総会プログラム・抄録集　31回　322-322　2008/10
Publisher: (NPO)日本高血圧学会
健診受診と死亡リスクの関連大崎国保コホート

寳澤篤, 栗山進一, 柿崎真沙子, 大森芳, 大久保孝義, 辻一郎

日本公衆衛生学会総会抄録集　67回　411-411　2008/10
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
高感度C反応性蛋白レベルと介護保険認定・死亡リスクに関する前向きコホート研究:鶴ケ谷プロジェクト

曽根稔雅, 牛凱軍, 中谷直樹, 大森芳, 東口みづか, 柿崎真沙子, 寳澤篤, 栗山進一, 辻一郎

J Epidemiol　18　(1 Supplement)　122　2008/01/25

ISSN： 0917-5040
睡眠時間と前立腺がん罹患リスクに関する前向きコホート研究:大崎国保コホート研究

柿崎真沙子, 柿崎真沙子, 井上圭祐, 栗山進一, 中谷直樹, 曽根稔雅, 大森芳, 福土審, 辻一郎

J Epidemiol　18　(1 Supplement)　54　2008/01/25

ISSN： 0917-5040
緑茶摂取と肺炎死亡リスクに関する前向きコホート研究:大崎国保コホート研究

渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 辻一郎

J Epidemiol　18　(1 Supplement)　210　2008/01/25

ISSN： 0917-5040
初産年齢と長期的死亡リスクに関する前向きコホート研究:大崎国保コホート研究

酒井太一, 中谷直樹, 角田雪香, 柿崎真沙子, 曽根稔雅, 大森芳, 栗山進一, 辻一郎

J Epidemiol　18　(1 Supplement)　108　2008/01/25

ISSN： 0917-5040
生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が医療費に及ぼす影響に関する研究—大崎国保コホート研究—

辻一郎, 栗山進一, 渡邊生恵, 柿崎真沙子, 中谷直樹, 大森芳

生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究平成19年度研究報告書　11-20　2008
生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究生活習慣,既往歴,日常生活の状況,人生観,健診・検診受診歴が死亡リスクに及ぼす影響に関する研究—大崎国保コホート研究—

辻一郎, 渡邊生恵, 柿崎真沙子, 栗山進一, 中谷直樹, 大森芳

生活習慣・健診結果が生涯医療費に及ぼす影響に関する研究平成19年度研究報告書　21-29　2008
Quality of life of patients and medical cost of "half elemental diet" as maintenance therapy for Crohn's disease: Secondary outcomes of a randomised controlled trial.

Takagi S, Utsunomiya K, Kuriyama S, Yokoyama H, Takahashi S, Umemura K, Iwabuchi M, Takahashi H, Takahashi S, Kinouchi Y, Hiwatashi N, Funayama Y, Sasaki I, Tsuji I, Shimosegawa T

Dig Liver Dis　?　2008

DOI： 10.1016/j.dld.2008.09.007 　
人間ドックの費用対効果なにがいくらでどこまでできるか基本健康診査成績と医療費との関連大崎国保コホート研究から

辻一郎, 大森芳, 島津太一, 寳澤篤, 栗山進一

日本医学会総会会誌　27回　(学術講演要旨)　140-140　2007/12
Publisher: 日本医学会
高齢者での低レベルの血清CRP濃度と体力低下との関連

牛凱軍, 寳澤篤, 郭輝, 栗山進一, 楊光, 大森芳, 中谷直樹, 高橋英子, 藤田和樹, 辻一郎, 永富良一

体力科学　56　(6)　806-806　2007/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
睡眠時間と死亡リスクに関する前向きコホート研究：大崎コホート研究 (Supplement to Journal of Epidemiology)

柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 福土審, 辻一郎

Supplement to Journal of Epidemiology　96　2007/10
In reply [4]

Shinichi Kuriyama, Yoshikazu Nishino, Yoshitaka Tsubono, Ichiro Tsuji

Journal of the American Medical Association　297　(4)　360-361　2007/01/24

ISSN： 0098-7484 1538-3598
効果的な介護予防ケアマネジメント技法の開発に関する研究生きがいと死亡リスクに関する前向きコホート研究

辻一郎, 曽根稔雅, 栗山進一, 中谷直樹, 大森芳, 島津太一, 菊地信孝, 柿崎真沙子

効果的な介護予防ケアマネジメント技法の開発に関する研究平成18年度研究報告書　34-43　2007
乳癌検診受診率向上のためにすべきことマンモグラフィ併用乳がん検診の生存率向上効果に関する研究

鈴木昭彦, 栗山進一, 大貫幸二, 武田元博, 石田孝宣, 西野善一, 辻一郎, 大内憲明

日本乳癌検診学会誌　16　(1)　37-37　2007
乳がん検診の精度及び効率の向上に関する研究 (厚生労働省がん研究助成金による研究報告書・平成18年度（総合研究報告）)

大内憲明, 内山菜智子, 東野英利子, 栗山進一, 福田護, 山田隆之

厚生労働省がん研究助成金による研究報告書・平成18年度（総合研究報告）　563-565　2007
乳がん検診の精度及び効率の向上に関する研究

大内憲明, 内山菜智子, 東野英利子, 栗山進一, 福田護

厚生労働省がん研究助成金による研究報告書・平成18年度　102-106　2007
パーソナリティと胃がん検診受診行動に関する横断研究

荒井志津葉, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 辻一郎

日本公衆衛生学会総会抄録集　65th　275　2006/10/15

ISSN： 1347-8060
コーヒー摂取と大腸がん罹患リスクに関する前向きコホート研究

長沼透, 栗山進一, ムニラアクタル, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 辻一郎

日本公衆衛生学会総会抄録集　65th　274　2006/10/15

ISSN： 1347-8060
【これからの生活習慣病対策】生活習慣病対策のエビデンス保健指導によって集団はどう変わるか? 疫学的視点からのアプローチ (保健師ジャーナル)

栗山進一

保健師ジャーナル　62　(10)　808-813　2006/10

DOI： 10.11477/mf.1664100319 　
日本人高齢者におけるC反応性蛋白と下肢閉塞性動脈硬化症の関連 (Arterial Stiffness)

寳澤篤, 大森芳, 栗山進一, 島津太一, 牛凱軍, 渡戸亜矢, 海老原覚, 松井敏史, 市来正隆, 永富良一, 佐々木英忠, 辻一郎

Arterial Stiffness　64-65　2006/10
【認知症実地診療における早期診断から介護まで】生活習慣と認知症食事健脳食はあるか (Medical Practice)

栗山進一

Medical Practice　23　(7)　1205-1209　2006/07
Epidemiologic studies on the impact of alcohol consumption upon the risk of cancer incidence : estimate of population attributable risk percent

TSUJI Ichiro, NAKAYA Naoki, KURIYAMA Shin-ichi

41　(3)　196-197　2006/06/28

ISSN： 1341-8963
Efficacy of weekend 5-ASA (mesalazine) enema as a maintenance therapy in patients with ulcerative colitis: A randomized controlled study

Hiroshi Yokoyama, Sho Takagi, Shinichi Kuriyama, Shuichiro Takahashi, Hiroki Takahashi, Masahiro Iwabuchi, Sciichi Takahashi, Yoshitaka Kinouchi, Ichiro Tsuji, Tooru Shimosegawa

GASTROENTEROLOGY　130　(4)　A480-A480　2006/04

ISSN： 0016-5085
Efficacy of "half elemental diet" as a maintenance therapy for Crohn's disease: Crohn's disease half elemental diet study in Sendai (CHESS): A randomized controlled trial

Sho Takagi, Kyoko Utsunomiya, Shinichi Kuriyama, Hiroshi Yokoyama, Shuichiro Takahashi, Masahiro Iwabuchi, Hiroki Takahashi, Seiichi Takahashi, Yoshitaka Kinouchi, Nobuo Hiwatashi, Yuji Funayama, Iwao Sasaki, Ichiro Tsuji, Tooru Shimosegawa

GASTROENTEROLOGY　130　(4)　A484-A484　2006/04

ISSN： 0016-5085
Association between depressive symptoms and cerebrovascular lesions on MRI in community-dwelling elderly individuals

SEKI Toru, AWATA Shuichi, KOIZUMI Yayoi, KINOMURA Shigeo, TAKI Yasuyuki, HOZAWA Atsushi, OHMORI Kaori, KURIYAMA Shinichi, FUKUDA Hiroshi, TSUJI Ichiro

Japanese journal of geriatrics　43　(1)　102-107　2006/01/25
Publisher: 日本老年医学会
DOI： 10.3143/geriatrics.43.102 　

ISSN： 0300-9173

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Aim: We conducted a community-based study to verify relationships between cerebrovascular lesions (CVL) on magnetic resonance imaging and depressive symptoms (DS) in elderly individuals, and the validity of Krishnan's MRI-defined vascular depression (MRI-VD). Methods: MRI was performed in 196 community-dwelling elderly individuals (mean age, 72.3±1.7 years; range, 70-75 years) with a Mini Mental State (MMS) score of 22 or more who participated in the comprehensive geriatric assessment. The DS (+) group consisted of 41 subjects with Geriatric Depression Scale (GDS) score of 15 or more. The DS (-) group consisted of 141 subjects with a GDS score of 9 or less. Hyperintensities of deep white matter and subcortical gray matter were scored according to the modified Fazekas criteria. The CVL score was defined as the higher of the two scores, and 3 grades were defined as scores of 0, 1, or 2 or more. According to Krishnan's MRI-VD, a CVL score of 2 or more was defined as CVL (+). Logistic regression analyses were used to test associations between CVL and DS, and univariate analyses were used to examine differences in clinical features between CVL (+) and CVL (-) within the DS (+) group. Results: Logistic regression analysis adjusting for age, sex, cognitive function, educational level, instrumental activities of daily life (IADL) and subjective healthiness, CVL scores of 1 and 2 or more displayed significant associations with DS compared with a score of 0. However, no significant differences in DS were found between CVL (+) and CVL (-). Within the DS (+) group, no significant differences were noted between CVL (+) and CVL (-) in MMS, IADL, subjective healthiness, sleeping symptoms, alcohol-related problem or suicidal ideation. Conclusion: CVL was associated with DS independent of various confounders. However, clarification of clinical profiles is required to define MRI-VD as an independent clinical entity.
潰瘍性大腸炎緩解維持療法におけるメサラジン週末注腸療法の有用性

横山大, 高木承, 栗山進一, 高橋秀一郎, 高橋広喜, 岩渕正広, 志賀永嗣, 松村吉史, 角田洋一, 阿部浩子, 今井豪, 土佐正規, 持田淳弘, 佐藤雄一郎, 野村栄樹, 根来健一, 高橋成一, 木内喜孝, 辻一郎, 下瀬川徹

日本消化器病学会雑誌　103　(臨増総会)　A297-A297　2006
高齢者の排尿機能に関する検討〜GDSを用いたうつ傾向との関連を中心として

池田義弘, 中川晴夫, 竹本淳, 海法康裕, 大森芳, 寶澤篤, 小泉弥生, 西野善一, 栗山進一, 辻一郎, 荒井陽一

日本泌尿器科学会雑誌　97　(2)　264-264　2006
40歳代超音波乳がん検診の救命効果の検討のためのアンケート調査結果

栗山進一, 大貫幸二, 鈴木昭彦, 宮本彰, 辻一郎, 大内憲明

日本乳癌検診学会誌　15　(1)　100-105　2006
Publisher: Japan Association of Breast Cancer Screening
DOI： 10.3804/jjabcs.15.100 　

ISSN： 0918-0729

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The objective of the present study was to collect data on the sensitivity and specificity of ultrasound mass-screening for breast cancer to investigate its effectiveness. We sent questionnaires to 31 representative institutions conducting breast cancer screening in Japan. Eighteen (58%) of these institutions returned the questionnaire and seven (23%) stated that they conducted ultrasound mass-screening for breast cancer. All seven institutions conducted annual screening, but not biennial screening, but only two reported sensitivity and specificity, in which false negativity was detected by methods other than a "population-based cancer registry". The sensitivity of annual combined mass-screening involving physical examination and ultrasound was 75. 0% and 93. 5%, respectively, and the corresponding specificity was 99.8% and 92.9%, respectively. Our results suggest that more data are needed to investigate the usefulness of ultrasound mass-screening for breast cancer in women aged 40 to 49.
超音波による乳癌検診は死亡率を減少させるかシミュレーション分析による40歳代超音波乳がん検診の救命効果及び効率の検討

栗山進一, 大貫幸二, 鈴木昭彦, 市村みゆき, 森久保寛, 東野英利子, 辻一郎, 大内憲明

日本乳癌検診学会誌　15　(3)　372-372　2006
乳癌検診受診率向上のためにすべきことマンモグラフィ併用乳がん検診の生存率向上効果に関する研究

鈴木昭彦, 栗山進一, 大貫幸二, 武田元博, 石田孝宣, 西野善一, 辻一郎, 大内憲明

日本乳癌検診学会誌　15　(3)　368-368　2006
乳がん検診の精度及び効率の向上に関する研究 (平成17年度厚生労働省がん研究助成金による研究報告書、国立がんセンター)

大内憲明, 内山菜智子, 東野英利子, 栗山進一, 福田護, 山田隆之

平成17年度厚生労働省がん研究助成金による研究報告書、国立がんセンター　191-195　2006
日本の地域社会の高齢者におけるC-反応性蛋白と高血圧の関連に及ぼす余暇の身体的活動の影響 Tsurugayaプロジェクト(Influence of Leisure-Time Physical Activity on the Relationship between C-reactive protein and Hypertension in a Community-Based Elderly Population of Japan: The Tsurugaya Project)

牛凱軍, 寶澤篤, 藤田和樹, 奥津光晴, 栗山進一, 辻一郎, 永富良一

体力科学　54　(6)　654-654　2005/12
Publisher: (一社)日本体力医学会
ISSN： 0039-906X

eISSN： 1881-4751
BMI(Body Mass Index)と循環器疾患(虚血性心疾患、脳血管疾患)による死亡

船田哲, 島津太一, 栗山進一, 佐藤ゆき, 大森芳, 西野善一, 辻一郎

日本公衆衛生学会総会抄録集　64回　601-601　2005/08
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
鉄摂取量と大腸がん罹患に関する前向きコホート研究

馬屋原孝恒, 佐藤ゆき, 栗山進一, 島津太一, 西野善一, 辻一郎

日本公衆衛生学会総会抄録集　64回　592-592　2005/08
Publisher: 日本公衆衛生学会
ISSN： 1347-8060
レセプト全傷病登録による糖尿病の合併症の医療費分析

鈴木寿則, 坪野吉孝, 栗山進一, 寳澤篤, 大森芳, 遠藤彰, 辻一郎

日本公衆衛生雑誌　52　(7)　652-663　2005/07
Publisher: 日本公衆衛生学会
DOI： 10.11236/jph.52.7_652 　

ISSN： 0546-1766
健康余命(ADL自立期間)の推移に関する性差

大森芳, 栗山進一, 島津太一, 菊地信孝, 佐藤ゆき, 宮本彰, ムニラアクタル, 柿崎真沙子, 佐藤文美, 辻一郎

東北公衆衛生学会講演集　54th　32　2005/07

ISSN： 0915-549X
Updated information on risk factors for lung cancer: Findings from the JACC study

K Wakai, M Ando, K Ozasa, Y Ito, K Suzuki, Y Nishino, S Kuriyama, N Seki, T Kondo, Y Watanabe, Y Ohno, A Tamakoshi

JOURNAL OF EPIDEMIOLOGY　15　S134-S139　2005/06

DOI： 10.2188/jea.15.S134 　

ISSN： 0917-5040
緑茶摂取と認知機能に関する横断研究鶴ヶ谷寝たきり予防健診

栗山進一, 寳澤篤, 大森芳, 島津太一, 松井敏史, 海老原覚, 粟田主一, 永富良一, 荒井啓行, 辻一郎

日本老年医学会雑誌　42　(Suppl.)　93-93　2005/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
飲酒習慣と医療費に関するコホート研究-大崎国保加入者コホート研究による成人男性の分析

安齋由貴子, 栗山進一, 西野善一, 大森芳, 辻一郎, 坪野吉孝, 大久保孝義, 瀬川香子

宮城県公衆衛生学会会誌　(37)　6-6　2005/03
Publisher: 宮城県公衆衛生学会
ISSN： 0912-747X
Effects of a comprehensive community intervention model to reduce late-life depression and suicidal ideation in an urban residential district

S Awata, T Seki, Y Koizumi, H Matsuoka, H Arai, R Nagatomi, A Hozawa, K Omori, S Kuriyama, Tsuji, I

INTERNATIONAL PSYCHOGERIATRICS　17　381-382　2005

ISSN： 1041-6102
Association between social support and depression status in the elderly: Results of a one-year community-based prospective cohort study in Japan

Y Koizumi, S Kuriyama, T Seki, K Ohmori, A Hozawa, Tsuji, I, H Matsuoka, S Awata

INTERNATIONAL PSYCHOGERIATRICS　17　355-355　2005

ISSN： 1041-6102
乳がん検診の精度及び効率の向上に関する研究 (平成16年度厚生労働省がん研究助成金による研究報告書、国立がんセンター)

大内憲明, 遠藤登喜子, 東野英利子, 栗山進一, 福田護, 藤田広志

平成16年度厚生労働省がん研究助成金による研究報告書、国立がんセンター　308-312　2005
P-254 高齢者を対象とした高血圧治療薬服用状況調査 : 鶴ヶ谷寝たきり予防健診の結果から(17.在宅医療・医薬分業,"薬剤師がつくる薬物治療"-薬・薬・学の連携-)

小林満, 大森芳, 海老原覚, 寳澤篤, 栗山進一, 尾形美樹子, 松井敏史, 辻一郎, 荒井啓行, 佐々木英忠

日本医療薬学会年会講演要旨集　14　280-280　2004/09/01
Publisher: 日本医療薬学会
DOI： 10.20825/amjsphcs.14.0_280_2 　
肉類摂取と大腸がん罹患に関する前向きコホート研究

佐藤ゆき, 中谷直樹, 栗山進一, 西野善一, 坪野吉孝, 辻一郎

東北公衆衛生学会誌　(53)　25-25　2004/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
福島県西会津町における町ぐるみ健康増進事業と10年間の変化

栗山進一, 寳澤篤, 島津太一, 藤田潤一, 渡部英樹, 新田幸恵, 辻一郎

東北公衆衛生学会誌　(53)　14-14　2004/07
Publisher: 東北公衆衛生学会
ISSN： 0915-549X
都市に在住する70歳以上の高齢者のソーシャル・サポートと抑うつ症状との関連性一年間の前向きコホート研究の結果について

小泉弥生, 粟田主一, 関徹, 大森芳, 栗山進一, 寶澤篤, 松岡洋夫, 辻一郎

老年精神医学雑誌　15　(5)　593-594　2004/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
都市の大規模住宅地域に在住する70歳以上高齢者の自殺念慮と関連要因 1年間のコホート研究

粟田主一, 関徹, 小泉弥生, 佐藤宗一郎, 大森芳, 栗山進一, 寶澤篤, 辻一郎, 松岡洋夫

老年精神医学雑誌　15　(5)　594-595　2004/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
地域在住の高齢者における頭部MRI上の脳血管性病変と抑うつ症状との関連横断的研究

関徹, 粟田主一, 小泉弥生, 木之村重男, 後藤了以, 井上健太郎, 瀧靖之, 寶澤篤, 大森芳, 栗山進一, 松岡洋夫, 福田寛, 辻一郎

老年精神医学雑誌　15　(5)　595-596　2004/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
高齢者における肥満とうつ状態に関する横断研究鶴ヶ谷寝たきり予防健診

栗山進一, 小泉弥生, 大森芳, 寳澤篤, 粟田主一, 荒井啓行, 佐々木英忠, 辻一郎

日本老年医学会雑誌　41　(Suppl.)　123-123　2004/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
地域高齢者の抑うつと医療費鶴ヶ谷寝たきり予防健診

大森芳, 鈴木寿則, 小泉弥生, 寳澤篤, 栗山進一, 粟田主一, 荒井啓行, 佐々木英忠, 辻一郎

日本老年医学会雑誌　41　(Suppl.)　138-138　2004/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
[Current controversy on the effectiveness of mammographic screening for breast cancer in western nations] (Gan To Kagaku Ryoho)

Kuriyama Shinichi, Tsuji Ichiro

Gan To Kagaku Ryoho　31　(2)　158-162　2004/02
【がん治療のControversy 乳がん】乳癌検診に関する欧米の論争 (癌と化学療法)

栗山進一, 辻一郎

癌と化学療法　31　(2)　158-162　2004/02
乳がん検診の精度及び効率の向上に関する研究 (平成15年度厚生労働省がん研究助成金による研究報告書、国立がんセンター)

大内憲明, 遠藤登喜子, 東野英利子, 栗山進一, 福田護, 藤田広志

平成15年度厚生労働省がん研究助成金による研究報告書、国立がんセンター　426-430　2004
【体質と環境】 Q.&A. 医療費に与える影響は? (Q&Aでわかる肥満と糖尿病)

栗山進一, 辻一郎

Q&Aでわかる肥満と糖尿病　2　(6)　114-115　2003/11
8-イソプロスタンは高血圧者で高値を示す

寳澤篤, 海老原覚, 大森芳, 栗山進一, 大久保孝義, 宇賀神卓嗣, 小泉弥生, 鈴木寿則, 松井敏史, 荒井啓行, 坪野吉孝, 今井潤, 佐々木英忠, 辻一郎

日本高血圧学会総会プログラム・抄録集　26回　154-154　2003/10
Publisher: (NPO)日本高血圧学会
都市部に在住する70歳以上の高齢者の抑うつ症状と脳血管性危険因子との関連

関徹, 粟田主一, 小泉弥生, 松岡洋夫, 佐藤宗一郎, 寶澤篤, 大森芳, 栗山進一, 辻一郎, 荒井啓行

老年精神医学雑誌　14　(5)　655-656　2003/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
鶴ヶ谷プロジェクト地域高齢者に対する総合機能評価の実施

大森芳, 寳澤篤, 栗山進一, 藤田和樹, 粟田主一, 荒井啓行, 永富良一, 佐々木英忠, 辻一郎

日本老年医学会雑誌　40　(Suppl.)　142-142　2003/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
都市部に在住する70歳以上高齢者の抑うつ症状,うつ病性障害,自殺念慮

粟田主一, 関徹, 小泉弥生, 松岡洋夫, 佐藤宗一郎, 寶澤篤, 大森芳, 栗山進一, 荒井啓行, 永富良一, 辻一郎

老年精神医学雑誌　14　(5)　659-659　2003/05
Publisher: (株)ワールドプランニング
ISSN： 0915-6305
家庭高血圧と8イソプロスタンの関連について鶴ヶ谷寝たきり予防健診

寳澤篤, 海老原覚, 大森芳, 宇賀神卓嗣, 栗山進一, 大久保孝義, 荒井啓行, 佐々木英忠, 今井潤, 辻一郎

日本老年医学会雑誌　40　(Suppl.)　130-130　2003/05
Publisher: (一社)日本老年医学会
ISSN： 0300-9173
健康増進の医学的・経済的効果 (体力科学)

栗山進一, 辻一郎

体力科学　52　(2)　199-205　2003/04
Publisher: 日本体力医学会
DOI： 10.7600/jspfsm1949.52.199 　

ISSN： 0039-906X
Suicidal ideation, depressive symptoms and depressive disorder in an elderly Japanese population

S Awata, T Seki, Y Koizumi, S Sato, H Matsuoka, H Arai, A Hozawa, K Omori, S Kuriyama, Tsuji, I

INTERNATIONAL PSYCHOGERIATRICS　15　296-297　2003

ISSN： 1041-6102
Association between depression and social support in the Japanese elderly population

Y Koizumi, S Awata, T Seki, N Nakaya, S Kuriyama, K Fujita, K Ohmori, A Hozawa, S Ebihara, H Arai, R Nagatomi, H Matsuoka, Tsuji, I

INTERNATIONAL PSYCHOGERIATRICS　15　272-272　2003

ISSN： 1041-6102
音への恐怖を示すタイプの広汎性発達障害児に対するピリドキシンの効果

上山真知子, 渡辺瑞香子, 玉橋征子, 村口至, 渡部徹, 栗山進一, 寶沢篤, 大久保孝義, 西野善一, 坪野吉孝, 辻一郎, 久道茂

臨床神経心理　13　55-58　2002/12
Publisher: 東北神経心理懇話会
ISSN： 1344-0292
Epidemiology of Lifestyle-related Diseases

KURIYAMA Shinichi

The journal of the Association of Life Insurance Medicine of Japan　100　(1)　27-34　2002/09/17
Publisher: The Association of Insuramce Medicine of Japan
ISSN： 0301-262X

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Our hygienic index level is highest in the world, and both the average life expectancy (male: 77.6 years old/female: 84.3 years old) and the healthy life expectancy (male: 71.9 years old/female: 77.2 years old) of the Japanese stand first in the world. As rapid aging of a population and westernization of our lifestyles is proceeding, however, the structure of diseases has changed and the incidence of life-style-related diseases is increasing. The incidence of cancer is markedly increasing among the three major diseases. Large bowel cancer is the first on the list of cancer of which incidence is increasing, in both males and females. A remarkable increase in the incidence of prostatic cancer in males and breast cancer in females is noted as well. By far the highest smoking rate of Japan among advanced countries is associated with the morbidity of lung cancer that is as high as ever. The incidence of ischemic heart diseases and cerebral infarction is increasing in heart diseases and cerebrovascular diseases respectively. A rapid increase in the incidence of diabetes mellitus is one of the most serious problems on the life insurance medicine and also for prolongation of the healthy life expectancy of the Japanese nation. Our changed lifestyles and the change in the structure of diseases with them suggest that in future we should not optimistically keep the longevity that Japan has stood first in the world.
広汎性発達障害児サブグループに対するビタミンB6の有効性に関する研究

渡辺瑞香子, 上山真知子, 玉橋征子, 村口至, 渡辺徹, 栗山進一, 寶澤篤, 大久保孝義, 西野善一, 坪野吉孝

脳と発達　34　(Suppl.)　S287-S287　2002/06
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

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Books and Other Publications 4

分子疫学入門 : 精密医療の基礎知識

栗山, 進一

東北大学出版会　2020/04

ISBN: 9784861633201
禁煙指導・支援者のための禁煙科学

日本禁煙科学会, ed. 辻一郎, 栗山進一

株式会社文光堂　2007/12
事例で学ぶ一般健診・特殊健診マニュアル

圓藤吟史, 栗山進一, 辻一郎他

宇宙堂八木書店　2006/05
子宮内膜症取扱い規約（第2部）-治療編・診療編-

石川睦男, 栗山進一

金原出版株式会社　2004/04

Presentations 90

東北メディカル・メガバンク事業－地域子ども長期健康調査事業の進捗に関する経過報告

菊谷昌浩, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 中村智洋, 中谷直樹, 寳澤篤, 長神風二, 鈴木洋一, 富田博秋, 辻一郎, 栗山進一, 山本雅之

第24回日本疫学会学術総会　2014/01/23
東北メディカル・メガバンク事業－三世代コホート調査に関する経過報告

目時弘仁, 小原拓, 石黒真美, 成川洋子, 菊谷昌浩, 栗山進一, 中谷直樹, 寳澤篤, 大隅典子, 清元秀泰, 菅原準一, 鈴木洋一, 富田博秋, 冨永悌二, 中谷純, 布施昇男, 峯岸直子, 辻一郎, 八重樫伸生, 山本雅之

第24回日本疫学会学術総会　2014/01/23
RELATIONSHIP BETWEEN MATERNAL CLINIC/HOME BLOOD PRESSURE DURING PREGNANCY AND BIRTH WEIGHT OF NEWBORNS IN NORMOTENSIVE WOMEN: THE BOSHI STUDY International-presentation

Noriyuki Iwama, Hirohito Metoki, Takayoshi Ohkubo, Mikiko Katagiri, Mami Ishikuro, Taku Obara, Katsuyo Yagihashi, Ryusuke Inoue, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Nobuo Yaegashi, Kazuhiko Hoshi, Masakuni Suzuki, Shinichi Kuriyama, Yutaka Imai

DOHad2013　2013/11/17
妊婦に対する気管支喘息治療薬の処方状況の把握に関する研究

保坂実樹, 小原拓, 目時弘仁, 佐藤倫広, 大久保孝義, 八重樫伸生, 眞野成康, 栗山進一

第23回日本医療薬学会年会　2013/09/21
小児の広汎性発達障害患者における処方推移:レセプトデータに基づく検討

佐藤倫広, 小原拓, 大場延浩, 森川和彦, 石黒真美, 目時弘仁, 西郡秀和, 菊谷昌浩, 眞野成康, 栗山進一

第23回日本医療薬学会年会　2013/09/21
治療中高血圧患者の高血圧管理における保険調剤薬局の関与：J-HOME-Morning研究

小原拓, 小林由香, 池田うらら, 保坂実樹, 佐藤倫広, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

第23回日本医療薬学会年会　2013/09/21
レセプトデータに基づく妊娠中の抗菌薬処方状況の把握に関する研究

堀川いずみ, 小原拓, 目時弘仁, 大久保孝義, 八重樫伸生, 眞野成康, 佐藤博, 栗山進一

第23回日本医療薬学会年会　2013/09/21
小児におけるインフルエンザワクチン接種の有効性評価

小原拓, 島崎信次郎, 金子健二, 福田純, 中村泰之, 眞野成康, 栗山進一, 八木直人

第23回日本医療薬学会年会　2013/09/21
地域子ども長期健康調査のこころとからだの支援

山中千鶴, 宮下真子, 成川洋子, 石黒真美, 小原拓, 目時弘仁, 菊谷昌浩, 寳澤篤, 辻一郎, 栗山進一

第49回宮城県公衆衛生学会学術総会　2013/07/12
子どもの発育状況に関する研究―初年度調査報告―

松原博子, 菊谷昌浩, 石黒真美, 田中総一郎, 細矢光亮, 千田勝一, 栗山進一, 呉繁夫

第49回宮城県公衆衛生学会学術総会　2013/07/12
児童におけるインフルエンザワクチン接種に関する検討

小原拓, 島崎信次郎, 栗山進一, 金子健二, 福田純, 中村泰之, 八木直人

第49回宮城県公衆衛生学会学術総会　2013/07/12
がんの危険を減らす確実な方法とあなたに最適ながん予防法

第52回日本消化器がん検診学会総会　2013/06/08
本邦の注意欠陥/多動性障害（ADHD)小児患者に対する併存障害別薬剤処方の現状

小原拓, 栗山進一

第55回日本小児神経学会学術集会　2013/05/30
東北メディカル・メガバンク事業：地域子どもコホート事業の進捗について

菊谷昌浩, 石黒真美, 小原拓, 目時弘仁, 中谷直樹, 寳澤篤, 辻一郎, 栗山進一

第23回日本疫学会学術総会　2013/01/24
東北メディカル・メガバンク事業（宮城）:三世代コホートの計画について

目時弘仁, 菊谷昌浩, 石黒真美, 小原拓, 中谷直樹, 西郡秀和, 杉山隆, 鈴木吉也, 鈴木洋一, 呉繁夫, 木村芳孝, 菅原準一, 八重樫伸生, 寳澤篤, 辻一郎, 栗山進一

第23回日本疫学会学術総会　2013/01/24
東北メディカル・メガバンク機構：山元町における住民意識調査

中谷直樹, 菊谷昌浩, 中谷純, 清元秀泰, 菅原準一, 富田博秋, 長神風二, 大隅典子, 栗山進一, 辻一郎, 寳澤篤

第23回日本疫学会学術総会　2013/01/24
東北メディカル・メガバンク機構：地域住民コホートの進捗について

寳澤篤, 中谷直樹, 菊谷昌浩, 目時弘仁, 小原拓, 石黒真美, 栗山進一, 辻一郎

第23回日本疫学会学術総会　2013/01/24
東北メディカル・メガバンク機構：参加促進・阻害要因に関するインタビュー調査

石黒真美, 小原拓, 櫻井香澄, 目時弘仁, 長神風二, 富田博秋, 瀧靖之, 中谷直樹, 菊谷昌浩, 寳澤篤, 辻一郎, 栗山進一

第23回日本疫学会学術総会　2013/01/24
本邦における小児の注意欠陥/多動性障害および広汎性発達障害に対する医薬品処方

小原拓, 大場延浩, 森川和彦, 石黒真美, 目時弘仁, 菊谷昌浩, 西郡秀和, 眞野成康, 栗山進一

第23回日本疫学会学術総会　2013/01/24
A Survey of Severe Allergic Symptoms Among Children In a Disaster-hit Area: Challenge of Tohoku Medical Megabank Organization International-presentation

Ishikuro M

World Allergy Organization International Scientific Conference　2012/12/06

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第2回WAO国際科学会議（WISC 2012）
東北メディカル・メガバンク事業とその目指すもの International-presentation

栗山進一

第1回NCGM国際シンポジウム　2012/11/16

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国立国際医療研究センター
Prescription of drugs for children with attention deficit/hyperactivity disorder (AD/HD) in Japan. International-presentation

Obara T, Ooba N, Morikawa Y, Ishikuro M, Metoki H, Kikuya M, Nishigori H, Mano N, Kuriyama S

The 7th Asian Conference on Pharmacoepidemiology (ACPE 7) meeting.　2012/10/26
本邦の注意欠陥/多動性障害（ADHD）小児患者に対する薬物治療の現状

小原拓, 大場延浩, 森川和彦, 石黒真美, 目時弘仁, 菊谷昌浩, 西郡秀和, 眞野成康, 栗山進一

第51回日本薬学会東北支部大会　2012/10/07

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青森大学
Prescription of Drugs during Pregnancy in Japan. International-presentation

Obara T, Akazawa M, Ohkubo T, Ishikuro M, Metoki H, Shono A, Nishigori H, Mano N, Yaegashi N, Kuriyama S

28th International Conference on Pharmacoepidemiology & Therapeutic Risk Management. (ISPE)　2012/08/23
睡眠時間と総死亡・死因別死亡リスク：大崎国保コホート研究

柿崎真沙子, 栗山進一, 中谷直樹, 曽根稔雅, 永井雅人, 菅原由美, 寳澤篤, 辻一郎

第48回宮城県公衆衛生学会学術総会　2012/07/12

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エル・パーク仙台
妊婦における薬剤の使用に関する疫学調査

小原拓, 石黒真美, 目時弘仁, 西郡秀和, 菊谷昌浩, 大久保孝義, 眞野成康, 八重樫伸生, 栗山進一

第48回宮城県公衆衛生学会学術総会　2012/07/12

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エル・パーク仙台
Clinic and out-of-clinic blood pressure change during pregnancy by parity: BOSHI Study International-presentation

Ishikuro M

ISSHP 2012　2012/07/09

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第18回国際妊娠高血圧研究会議 (ISSHP 2012) International Society for the Study of Hypertension in Pregnancy World Congress
降圧治療中患者における外来血圧変動の規定因子: J-HOME-Morning研究

小原拓, 石倉一樹, 芝宮拓, 池田うらら, 目時弘仁, 菊谷昌浩, 眞野成康, 栗山進一, 大久保孝義, 今井潤, HOME-Morning研究グループ

第14回時間循環血圧研究会　2012/07/07

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東京商工会議所
レセプトデータに基づく妊娠中の医薬品使用状況の把握に関する研究

小原拓, 石黒真美, 目時弘仁, 西郡秀和, 大久保孝義, 眞野成康, 八重樫伸生, 栗山進一

第15回日本医薬品情報学会総会・学術大会　2012/07/07

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近畿大学東大阪本部キャンパス
治療中高血圧患者の高血圧管理における保険調剤薬局の関与：J-HOME-Morning研究より

小原拓, 小林由香, 池田うらら, 菊谷昌浩, 目時弘仁, 井上隆輔, 大久保孝義, 眞野成康, 栗山進一, 今井潤

第1回臨床高血圧フォーラム　2012/05/12

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千里ライフサイエンスセンター
エネルギー摂取の違いからみた食べる早さと肥満の関連：大崎コホート2006研究

永井雅人, 高橋誠, 栗山進一, 柿崎真沙子, 遠又靖丈, 渡邉崇, 寳澤篤

第22回日本疫学会学術総会　2012/01/26
妊娠高血圧患者における降圧治療状況：レセプトデータに基づく検討

小原拓, 大久保孝義, 目時弘仁, 西郡秀和, 石黒真美, 眞野成康, 赤沢学, 八重樫伸生, 栗山進一

第22回日本疫学会学術総会　2012/01/26
レセプトデータを用いた妊娠高血圧患者に対する降圧薬処方状況の把握

小原拓, 大久保孝義, 目時弘仁, 西郡秀和, 石黒真美, 眞野成康, 赤沢学, 八重樫伸生, 栗山進一

日本薬剤疫学会第17回学術総会　2011/11/05
妊娠と医薬品使用に関する問い合わせ内容の調査

小原拓, 尾崎芙実, 吉中千佳, 前川麻央, 草場美津江, 飯田優太郎, 鈴木文子, 松浦正樹, 佐賀利英, 佐藤真由美, 久道周彦, 島田美樹, 栗山進一, 八重樫伸生, 眞野成康

第50回記念日本薬学会東北支部大会　2011/10/30
降圧治療中患者における家庭血圧日間変動の規定因子：J-HOME-Morning研究

小原拓, 石倉一樹, 菊谷昌浩, 加藤哲夫, 芝宮拓, 新木貴大, 池田うらら, 小林由香, 目時弘仁, 眞野成康, 栗山進一, 大久保孝義, 今井潤

第34回日本高血圧学会総会　2011/10/20
妊婦の出生体重及び妊娠前肥満度と妊娠中の家庭血圧測定：BOSHI研究

山本真実, 佐藤友里恵, 目時弘仁, 大久保孝義, 阿久津好美, 石黒真美, 櫻井香澄, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

第34回日本高血圧学会総会　2011/10/20
正常妊娠における妊娠初期ヘマトリット(Ht) と家庭血圧推移との関連:BPSHI研究

阿久津好美, 佐々木彩乃, 目時弘仁, 大久保孝義, 小原拓, 櫻井香澄, 八木橋香津代, 森滋, 鈴木雅洲, 佐藤博, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

第34回日本高血圧学会総会　2011/10/20
妊娠期間中血圧推移と妊婦の母親の妊娠期間中有血圧レベルとの関連：BOSHI研究

目時弘仁, 星川美奈子, 大久保孝義, 阿久津好美, 小原拓, 櫻井香澄, 片桐未希子, 岩間憲之, 八木橋香津代, 森滋, 鈴木雅洲, 栗山進一, 松原洋一, 八重樫伸生, 今井潤

第34回日本高血圧学会総会　2011/10/20
高齢者における心理的苦痛と要介護認定・死亡リスクの関連大崎コホート2006研究

渡邉崇, 柿崎真沙子, 中谷直樹, 永井雅人, 遠又靖丈, 坪谷透, 栗山進一, 辻一郎

第70回日本公衆衛生学会　2011/10/19
血清イソフラボン濃度と要介護認定・死亡の関連鶴ヶ谷コホート研究

寳澤篤, 菅原由美, 遠又靖丈, 柿崎真沙子, 坪谷透, 大森芳, 栗山進一, 深尾彰, 辻一郎

第70回日本公衆衛生学会総会　2011/10/19
自閉症におけるビタミンB6 反応性を予測する徴候・バイオマーカーの解明

栗山進一, 大内美南, 稲垣真澄, 角田和彦, 栗原亞紀, 安原昭博, 渡辺瑞香子, 上山真知子, 福地成, 加我牧子

第53回日本小児神経学会総会　2011/05/26
「やぶきた」または「べにふうき」緑茶摂取と血中コレステロール値に関するランダム化比較試験：掛川スタディ介入研究

栗山進一, 鮫島庸一, 山本(前田)万里, 立花宏文, 小原拓, 櫻井香澄, 石黒真美, 尾島俊之

第21回日本疫学会学術総会　2011/01/21
Weight change since age 20 years and cardiovascular disease mortality The Ohsaki Study

Wan-Ting Chou, Masako Kakizaki, Yasutake Tomata, Masato Nagai, Yumi Sugawara, Shinichi Kuriyama, Ichiro Thuji

第21回日本疫学会学術総会　2011/01/21
成人期の体重変化と前立腺がんリスク：大崎国保コホート研究

永井雅人, 菅原由美, 周婉婷, 坪谷透, 西野善一, 柿崎真沙子, 栗山進一, 辻一郎

第21回日本疫学会学術総会　2011/01/21
ガンマグルタミン酸転移酵素（GGT）とがん罹患リスクとの関連：大崎国保コホート研究

坪谷透, 栗山進一, 永井雅人, 寳澤篤, 菅原由美, 柿崎真沙子, 西野善一, 辻一郎

第21回日本疫学会学術総会　2011/01/21
睡眠時間と要介護認定・死亡リスクに関する前向きコホート研究：鶴ヶ谷プロジェクト

柿崎真沙子, 上川康貴, 中谷直樹, 曽根稔雅, 遠又靖丈, 坪谷透, 渡邊生恵, 寳澤篤, 栗山進一, 辻一郎

第21回日本疫学会学術総会　2011/01/21
健診受診と死亡率の関連 Propensity Score Matched Cohort Analysis を用いた検討

寳澤篤, 栗山進一, 渡邊生恵, 柿崎真沙子, 大森芳, 曽根稔雅, 永井雅人, 菅原由美, 新田明美, 李強, 大久保孝義, 村上義孝, 辻一郎

第21回日本疫学会学術総会　2011/01/21
授乳方法と性ホルモン関連がん罹患リスクに関する前向きコホート研究：大崎国保コホート研究

菅原由美, 柿崎真沙子, 永井雅人, 遠又靖丈, 星玲奈, 渡邊生恵, 西野善一, 栗山進一, 辻一郎

第21回日本疫学会学術総会　2011/01/21
Green tea consumption and the risk of long-term care insurance 緑茶摂取と要介護認定・死亡リスクに関する研究

遠又靖丈, 寳澤篤, 栗山進一, 菅原由美, 曽根稔雅, 中谷直樹, 大森芳, 辻一郎

国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会　2010/01/09
Green tea consumption and the risk of liver cancer incidence 緑茶摂取と肝がん罹患に関する前向きコホート研究

宇井あかね, 栗山進一, 柿崎真沙子, 曽根稔雅, 中谷直樹, 大森(松田)芳, 寳澤篤, 西野善一, 辻一郎

国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会　2010/01/09
Impact of walking upon life expectancy and lifetime medical expenditure 歩行時間と平均余命及び障害医療費との関連について

永井雅人, 栗山進一, 大森(松田)芳, 寳澤篤, 辻一郎, 橋本修二

国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会　2010/01/09
Adulthood weight change and the risk of colorectal cancer:the Osaki Cohot Study 成人期の体重変化と大腸がんリスク：大崎国保コホート研究

菅原由美, 栗山進一, 永井雅人, 遠又靖丈, 寳澤篤, 西野善一, 辻一郎

国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会　2010/01/09
体格と生涯医療費の関連ー大崎国保コホート研究ー

永井雅人, 栗山進一, 柿崎真沙子, 大森芳, 寳澤篤, 橋本修二, 辻一郎

第68回公衆衛生学会総会　2009/10/21
要介護認定に対する基本チェックリストの予測妥当性の検証：大崎コホート2006研究

遠又靖丈, 寳澤篤, 大森芳, 永井雅人, 菅原由美, 新田明美, 栗山進一, 辻一郎

第68回日本公衆衛生学会総会　2009/10/21
高齢者における血圧と要介護認定の関連ー鶴ヶ谷コホート研究ー

寳澤篤, 栗山進一, 大森芳, 曽根稔雅, 新田明美, 菅原由美, 中谷直樹, 牛凱軍, 粟田主一, 辻一郎

第32回日本高血圧学会総会　2009/10/01
家庭血圧で測定された血圧の季節変動性についての検討

寳澤篤, 栗山進一, 島津太一, 大森芳, 辻一郎

第58回東北公衆衛生学会　2009/07/24
音過敏を有する広汎性発達障害事例に対するピリドキシン投与の有効性評価

上山真知子, 栗山進一, 渡辺瑞香子

第51回日本小児神経学会総会　2009/05/28
緑茶摂取頻度とK６得点との関連ー大崎コホート2006研究ー

寳澤篤, 栗山進一, 中谷直樹, 大森芳, 柿崎真沙子, 曽根稔雅, 永井雅人, 新田明美, 菅原由美, 牛凱軍, 辻一郎

第19回日本疫学会　2009/01/23
抹消動脈疾患と要介護発生に関する眼向きコホート研究〜鶴ヶ谷プロジェクト〜

新田明美, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 海老原覚, 市来正隆, 荒井啓行, 辻一郎

第19回日本疫学会　2009/01/23
Motor Fitness Scale と要介護発生・死亡リスクに関する前向きコホート研究ー鶴ヶ谷プロジェクトー

星真行, 寳澤篤, 栗山進一, 中谷直樹, 大森芳, 曽根稔雅, 柿崎真沙子, 牛凱軍, 藤田和樹, 植木章三, 芳賀博, 永富良一, 辻一郎

第19回日本疫学会　2009/01/23
Green Tea consumption and the Risk of Lung Cancer:The Ohsaki Study

Qiang Li, Masako Kakizaki, Shinichi Kuriyama, Toshimasa Sone, Hong Yan, Naoki Nakaya, Kaori Matsuda-Ohmori, Ichiro Tsuji

第19回日本疫学会　2009/01/23
睡眠時間と乳癌罹患リスクに関する前向きコホート研究：大崎国保コホート研究

柿崎真沙子, 栗山進一, 曽根稔雅, 大森芳, 寳澤篤, 中谷直樹, 福土審, 辻一郎

第19回日本疫学会　2009/01/23
性別にみたBMIと死因別死亡リスクに関する前向きコホート研究ー大崎国おコホート研究ー

永井雅人, 柿崎真沙子, 栗山進一, 大森芳, 菅原由美, 曽根稔雅, 寳澤篤, 辻一郎

第19回日本疫学会　2009/01/23
魚摂取と大腸がん罹患リスクに関する前向きコホート研究：大崎国保コホート研究

菅原由美, 柿崎真沙子, 栗山進一, 大森芳, 曽根稔雅, 寳澤篤, 西野善一, 辻一郎

第19回日本疫学会　2009/01/23
要介護認定者における要介護状態区分の推移に関する研究

曽根稔雅, 中谷直樹, 大森芳, 寳澤篤, 栗山進一, 辻一郎

第67回日本公衆衛生学会総会　2008/11/05
検診受診と死亡リスクの関連ー大崎国保コホートー

寳澤篤, 栗山進一, 柿崎真沙子, 大森芳, 大久保孝義, 辻一郎

第67回日本公衆衛生学会総会　2008/11/05
年齢階級別のBMIと全死因死亡リスクとインスリン感受性

永井雅人, 栗山進一, 寳澤篤, 辻一郎

第29回日本肥満学会　2008/10/24
JNC7分類における高血圧分類と循環器疾患死亡の関連ー大崎国保コホートー

寳澤篤, 栗山進一, 大森芳, 大久保孝義, 辻一郎

第31回日本高血圧学会総会　2008/10/09
睡眠時間と前立腺がん罹患リスクに関する前向きコホート研究：大崎国保コホート研究

柿崎真沙子, 井上圭祐, 栗山進一, 中谷直樹, 曽根稔雅, 大森芳, 福土審, 辻一郎

第18回日本疫学会学術総会　2008/01/25
肺がん患者における否定的な心理状態と生命予後の関連

中谷直樹, 中谷久美, 明智龍男, 栗山進一, 稲垣正俊, 菊地信孝, 永井完治, 津金昌一郎, 西脇裕, 辻一郎, 内富庸介

第18回日本疫学会学術総会　2008/01/25
初産年齢と長期的死亡リスクに関する前向きコホート研究：大崎国保コホート研究

酒井太一, 中谷直樹, 角田雪香, 柿崎真沙子, 曽根稔雅, 大森芳, 栗山進一, 辻一郎

第18回日本疫学会学術総会　2008/01/25
全国疫学調査によるモヤモヤ病の患者数推計と臨床疫学像

栗山進一, 日下康子, 藤村幹, 若井建志, 玉腰暁子, 橋本修二, 辻一郎, 稲葉裕, 吉本高志

第18回日本疫学会学術総会　2008/01/25
緑茶摂取と子宮体がん発症リスクに関する症例対照研究

角田雪香, 中谷直樹, 藤田愛, 小泉俊光, 岡村智佳子, 永瀬智, 新倉仁, 大森芳, 栗山進一, 田勢亨, 伊藤潔, 八重樫伸生, 辻一郎

第18回日本疫学会学術総会　2008/01/25
緑茶摂取と肺炎死亡リスクに関する前向きコホート研究：大崎国保コホート研究

渡邊生恵, 栗山進一, 柿崎真沙子, 曽根稔雅, 大森芳, 中谷直樹, 辻一郎

第18回日本疫学会学術総会　2008/01/25
高感度C反応性タンパックレベルと介護保険認定・死亡リスクに関する前向きコホート研究：鶴ヶ谷プロジェクト

曽根稔雅牛, 軍, 中谷直樹, 大森芳, 東口みづか, 柿崎真沙子, 寳澤篤, 栗山進一, 辻一郎

第18回日本疫学会学術総会　2008/01/25
Green tea consumption and cognitive function: a cross-sectional study. International-presentation

Kuriyama Shinichi

3rd International Conference on Polyphenols and Health.　2007/11/26
Green tea consumption and cognitive function: Evidence from a cross-sectional study. International-presentation

Kuriyama Shinichi

The Third International Conference on O-CHA (Tea) Culture and Science.　2007/11/02
Green tea and cardiovascular disease mortality: Evidence from a prospective cohort study . International-presentation

Kuriyama Shinichi

Fourth International Scientific Symposium on Tea & Human Health　2007/09/18
生活習慣（食）と認知症-緑茶の効用-

栗山進一

第21回老年期痴呆研究会　2007/07/28
緑茶摂取と全死因死亡、循環器疾患死亡、がん死亡リスクに関する前向きコホート研究

栗山進一

第61回日本栄養・食糧学会大会　2007/05/19
緑茶摂取と全死因死亡、循環器疾患死亡、がん死亡リスクに関する前向きコホート研究

栗山進一, 島津太一, 大森芳, 菊地信孝, 中谷直樹, 西野善一, 坪野吉孝, 辻一郎

第17回日本疫学会学術総会　2007/01/26
飲酒と自殺リスクに関する前向きコホート研究：大崎コホート研究

中谷直樹, 菊地信孝, 島津太一, 大森芳, 栗山進一, 辻一郎

第17回日本疫学会学術総会　2007/01/26
体重変化と死亡リスクに関する前向きコホート研究：大崎コホート研究

島津太一, 栗山進一, 大森芳, 菊地信孝, 中谷直樹, 辻一郎

第17回日本疫学会学術総会　2007/01/26
身体の痛みと自殺完遂リスクに関する前向きコホート研究：大崎コホート研究

菊地信孝, 大森芳, 島津太一, 中谷直樹, 栗山進一, 辻一郎

第17回日本疫学会学術総会　2007/01/26
睡眠時間と死亡リスクに関する前向きコホート研究：大崎コホート研究

柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 福土審, 辻一郎

第17回日本疫学会学術総会　2007/01/26
生きがいと死亡リスクに関する前向きコホート研究：大崎コホート研究

曽根稔雅, 中谷直樹, 大森芳, 島津太一, 柿崎真沙子, 菊地信孝, 栗山進一, 辻一郎

第17回日本疫学会学術総会　2007/01/26
低栄養と介護保険認定・死亡リスクに関するコホート研究：鶴ヶ谷プロジェクト

東口みづか, 中谷直樹, 大森芳, 島津太一, 寳澤篤, 栗山進一, 辻一郎

第17回日本疫学会学術総会　2007/01/26
パーソナリティと胃がん検診受診行動に関する横断研究

荒井志津葉, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 栗山進一, 辻一郎

第65回日本公衆衛生学会　2006/10/25
コーヒー摂取と大腸がん罹患リスクに関する前向きコホート研究

長沼透, 栗山進一, アクタル・ムニラ, 柿崎真沙子, 中谷直樹, 大森芳, 島津太一, 辻一郎

第65回日本公衆衛生学会　2006/10/25
アルコール摂取の発がん影響に関する疫学研究-人口寄与危険度の推定-

辻一郎, 中谷直樹, 栗山進一

第41回日本アルコール・薬物医学会　2006/07/27

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Research Projects 22

大規模災害後の間接的死亡の検討：特定非常災害を網羅した災害後の超過死亡の一般化

大類真嗣, 岩本萌, 江川新一, 栗山進一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2025/04 - 2028/03
Development and Validation of a Combined Risk Prediction Model for Childhood Obesity Using Cord Blood Genomics and Epigenomics

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Iwate Medical University

2023/04/01 - 2026/03/31
Development and Validation of a Combined Risk Prediction Model for Childhood Obesity Using Cord Blood Genomics and Epigenomics

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Iwate Medical University

2023/04/01 - 2026/03/31
川崎病の罹患および重症化に関連する因子の解明に資する網羅的解析

松崎芙実子, 栗山進一, 上野史彦

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2022/04/01 - 2025/03/31
日米英蘭の先端ゲノムコホートと戦略的AI解析技術を用いた多因子疾患の病態解明

栗山進一, 松崎芙実子

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2022/04/01 - 2025/03/31
深層学習を用いたクラスタリングとGWAS解析による低出生体重の病態解明

大沼ともみ, 栗山進一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2021/04/01 - 2024/03/31

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低出生体重の遺伝的原因を探索するべく、今年度は以下①～③を行った。①解析パイプラインの開発②深層学習を用いたクラスタリングアルゴリズムの開発③低出生体重児の病型のクラスタリング ①解析パイプラインの開発では、パイプライン処理とは複数のプログラムにまたがり実行される解析処理を一連のプログラムにしておく処理のことで、事前にパイプライン処理の開発を行っておくことで、再現性と実行効率化を図ることができる。パイプライン処理の内容は前処理とメイン処理に分けて設計した。前処理はさらに、対象者の選定・対応する表現型データの抽出・対応する遺伝型データの抽出・使用変数のダミー化に分かれる。メイン処理は、深層学習によるクラスタリング・クラスタに分けたGWAS処理に分かれる。パイプライン処理の設計と開発には、東北大学東北メディカル・メガバンク機構内に設置してあるスーパーコンピュータを利用した。また、クラウド環境もテスト的にプログラム作成のために利用した。前処理の対象者の選定は、東北大学東北メディカル・メガバンク機構のコホート調査で収集された対象者を母集団としている。その後の、対応する表現型データの抽出には同じく東北メディカル・メガバンク機構で収集した遺伝型を使用している。 ②深層学習を用いたクラスタリングアルゴリズムの開発では、最新の深層学習手法としてDeep Embedded ClusteringやAutoEncoderなどのクラスタリング手法の文献調査を行った。妥当性の指標や適用するべき最適なデータ形態について調査した。その調査結果をもとにして、pythonを用いてアルゴリズム開発を行った。 ③低出生体重児の病型のクラスタリングでは、深層学習手法で使用されるハイパーパラメータ群を調整しクラスタリングを行っている。
Association between intestinal flora and preterm birth/low birth weight driven by detailed dietary survey

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Research (Exploratory)

Institution: Tohoku University

2020/07/30 - 2023/03/31
乳癌罹患リスク低減に向けた遺伝子多型、生活習慣、血漿メタボロームの統合解析

石田孝宣, 寳澤篤, 布施昇男, 濱中洋平, 小柴生造, 栗山進一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2020/04/01 - 2023/03/31

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乳癌死亡数を減らすためには、個々の女性の乳癌罹患リスクを的確に評価し、そのリスクを低減することは重要な課題である。本研究は、日本人女性が自分の遺伝子多型と血漿メタボローム情報をもとに、乳癌罹患リスクを低減するために生活習慣をどのように改善すればよいかを知り、その効果を血漿メタボローム変化で知る個別化予防の構築を目的とする。本研究はToMMoおよび大学病院のバイオバンクを利活用して、一般住民と乳癌患者の遺伝子多型、生活習慣、血漿メタボロームのデータを用いて解析する。乳癌罹患リスクに関連のある84の遺伝子多型、8つの血漿代謝物、改善・変更可能な身体情報・生活習慣（食習慣、住環境、睡眠、運動、嗜好、内服薬など）、および乳癌罹患の情報を用いて解析を行う。コホート参加者の生活調査は登録時に行われており、全コホート参加者の全ゲノムシークエンスもしくはアレイ解析によるゲノム解析、血漿メタボローム解析が進められている。メタボローム解析は、NMR、GC-MS、LC-MSの3法が用いられおり、標的メタボローム解析法のMXp Quant 500 Kitを用いたLC-MS解析（500代謝物）は1,000人以上の成人女性に行われる予定である。東北大学病院に通院している乳癌既往者約1,700人のうち、乳癌術後の無再発患者は約1,300人である。2021年度末には、計約800人が登録して血液検体保存がされる見込みであり、2022年度以降に、ToMMoが開発したSNPアレイであるジャポニカアレイNEOを用いたゲノム解析およびMXp Quant 500 Kitを用いたLC-MS解析を行う計画である。以上の全体の研究実施計画のうち、2021年度は、大学病院においては乳癌患者のバイオバンク登録をすすめるとともに、メタボローム解析を行うためのデータ整理を行った。
Maternal use of pharmaceuticals during pregnancy and congenital malformations in offspring.

Nishigori Hidekazu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Fukushima Medical University

2019/04/01 - 2022/03/31

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We used a large administrative claim database to examine the use of pharmaceuticals by pregnant women and the development of their offspring. The dates of pregnancy onset and delivery were estimated using the developed algorithms. More than 30,000 pregnant women were registered in the administrative claim database. We found no significant association between the major congenital malformations of the offspring and (1) early pregnancy prescriptions of propulsive with domperidone, (2) early pregnancy prescriptions of antihypertensive agents including amlodipine and methyldopa, and (3) early pregnancy prescriptions of calcineurin inhibitors, which are immunosuppressive drugs.
Strategic approach to identify etiology of atopic dermatitis and autism spectrum disorders using an add-on investigation of genome cohort

Shinichi Kuriyama

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2022/03/31

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In atopic dermatitis (AD), two dermatologists observed 1,170 patients, and 1,060 were in agreement. The prevalence of AD with concordant opinions was calculated to be 25.6%, and compared to the prevalence of 11.0% based on the questionnaire, the prevalence of original AD was found to be 2.3 times higher. In autism spectrum disorder (ASD), genome-wide association analysis (GWAS) showed that no significant associations were observed in analyses that treated the potentially heterogeneous population grouped together under the conventional disease name ASD as a lump. When the patient group was divided into more similar clusters based on symptoms and other factors, and a GWAS based on these clusters was performed, 65 significant loci were identified.
Preparation and Application of Y chromosome Panel using BirThree Cohort Men

Suzuki Kichiya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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More than 10% of the causes of infertility are considered to be male factors, and genomic abnormalities are attracting attention as one of the causes. The purpose of this study was to construct a reference panel related to fertility based on the genomic basis cultivated so far. A reference panel derived from a male with fertility was created from the whole genome data held by the Tohoku Medical Megabank Organization, and the whole genome data obtained from 17 semen samples of male infertility patients was used for the subsequent analysis. However, in the end, 180K SNPs were detected, and 11K of AF>0.8 were detected. This result will be an important platform for the genome analysis of male infertility in the future.
Elucidation of autism etiology by combination of phenotype clustering and high-dimensional variables selection method

KURIYAMA SHINICHI, Yamanaka Chizuru, Matsubara Hiroko, Nagai Masato, Obara Taku

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2016/04/01 - 2019/03/31

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We investigated whether machine learning methods could potentially identify a subgroup of persons with autism spectrum disorder (ASD) who show vitamin B6 responsiveness by selected phenotype variables. We analyzed the existing data from our intervention study with 17 persons. The affinity propagation analysis showed good classification of three potential vitamin B6-responsive persons with ASD. The k-medoids analysis also showed good classification. We show a two-step genome-wide association study (GWAS). In the first step, we observed no significant associations in a GWAS including 597 cases and 370 controls. In the second step, we conducted a cluster analysis using k-means with 15 clusters based on Autism Diagnostic Interview-Revised (ADI-R) scores and history of vitamin treatment. We then conducted GWAS by each subgroup of cases vs all controls (cluster-based GWAS) and identified significant associations with 93 chromosomal loci that satisfied the genome-wide significance threshold.
Establishment of a simple screening method for citrin deficiency and exploration on food preferences

Kuriyama Shinichi, KIKUYA Masahiro, ISHIKURO Mami, KIKUCHI Atsuo, MIYASHITA Masako

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2015/04/01 - 2018/03/31

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To detect citrin deficiency during the asymptomatic period, we distributed a parent-administered questionnaire, which focused on specific food preferences of disliking sweets and preferring high protein and high fat foods, to 62,895 children in elementary and junior high school. We obtained 16,468 responses, and 84 children had these specific food preferences. After excluding children whose parents did not want a telephone contact and those without available contact details, we asked the parents of 32 children if they would allow their child to undergo a genetic test of the SLC25A13 gene. DNA extracted from the collected saliva of these 13 children was examined for 6 prevalent mutations in the SLC25A13 gene. Although two of these 13 children were heterozygous carriers, one child with c.851_854delGTAT and one with c.1177+1G>A, no homozygous carrier was detected. This result suggested that heterozygotes might have specific food preferences similar to citrin deficiency.
Surveys of novel risk factors for perinatal depression: A large-scale cohort epidemiological research project and a claims data-based study in Japan.

NISHIGORI Hidekazu, KURIYAMA Shinichi, YOSHIDA Keiko, YAEGASHI Nobuo, OBARA Taku, NISHIGORI Toshie, SUGAWARA Junichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2012/04/01 - 2015/03/31

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In coastal areas of Miyagi and Iwate, damaged by the 2011 Great East Japan Earthquake,exposure to tsunami, the destruction of homes and dissatisfaction with living conditions were more likely to cause perinatal depression in women who delivered after the disaster.Percentage of women who gave birth and their spouses with scores ≧9 on the Edinburgh Postnatal Depression Scale 1 month post discharge were 11.8% and 8.4%, respectively, and with scores ≧7 on the Mother-Infant Bonding Scale 1 month post discharge were 3.5% and 6.3%, respectively. The study evaluated the claims data of 8020 pregnant women from the Japan Medical Data Center. Percentage of prescription rates of psychotropic drugs is 3.43% during perinatal term, 10.3% within 7 days of delivery, and 0.59% for postnatal within a year.
Elucidation of Sensory Systems for Food Factors in View of Molecular Epidemiology and Chemical Biology

TACHIBANA Hirofumi, FUJIMURA Yoshinori, TANAKA Hiroshi, KURIYAMA Shinichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (S)

Institution: Kyushu University

2010/04/01 - 2015/03/31

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We identified several genes, molecules, pathways, and networks of sensory systems for food factors to exhibit their functionality by using genetic suppressor element methodology. We succeeded to develop a novel in situ label-free mass spectrometry imaging technique for visualizing food factors and their metabolites and visualized biotransformation of food factors within mammalian tissue micro-regions after oral dosing. We also validated sensory systems for food factors in view of molecular epidemiology.
Cumulative impact of exposures for children; based on three generations cohort study

KURIYAMA SHINICHI

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2011/04/01 - 2014/03/31

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We added the additional study 'Cumulative impact of exposures for children; based on three generations cohort study' on the Japan Environment and Children's Study (JECS) to clarify the cumulative impact of exposures for children based on three generations cohort study. The JECS, a birth cohort study involving 100,000 parent-child pairs, was launched in 2011 in order to evaluate the impact of various environmental factors on children's health and development. At April 30, 2014, 6,060 and 3,657 mothers (pregnant women) and 4,118and 1,510 fathers were recruited for the JECS and the additional study, respectively. No differences on the characteristics were observed between who participated in the additional study and those who did not. It is expected that three generations cohort will be constructed by the additional recruitment of grandfathers and grandmothers.
Development of method for urine sample collection in infant

KURIYAMA Shinichi, METOKI Hirohito, INOUE Ryusuke

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Challenging Exploratory Research

Institution: Tohoku University

2011 - 2012

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Finally, 150 infants (76 boys; breastfeeding, 79 infants; mean age, 6.3+/-2.8 months;mean height, 68.0+/-8.8 cm; mean weight, 8.0+/-2.4 kg; gestational age, 39.5+/-1.9 weeks)participated in this study. Of those, we could collect urine sample from 70 infants. Mean day and time for collection of their urine sample was 5 days and 10.3 minutes, respectively. Characteristics of infants were not different between infants who could get urine sample and those who could not. We found that about a half of infants could collect their urine sample using a procedure which we proposed.
Basic study to improve the accuracy of mammography screening

SUZUKI Akihiko, OUCHI Noriaki, ISHIDA Takanori, KURIYAMA Shinichi, KAWAI Masaaki, AMARI Masakazu

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2009 - 2011

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In order to assess the accuracy of mammography screening, we investigate the clinical stage and mortality of breast cancer using a population-based cancer registry as four groups, screening detected group, interval cancer of mammography screening group, clinical breast examination detected group, and self detected group, respectively. Mammography detected group shows the lowest mortality among four groups, and screening detected group was the second. Usefulness of mammography screening was confirmed in this study.
Effects of vitamin B6 on children with autism : a randomized controlled trial

KURIYAMA Shinichi, KAGA Makiko, KURE Shiego, YASUHARA Akihiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2007 - 2009

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To investigate the factors that predict vitamin B6 responsiveness in children with autism, we conducted an intervention study and 17 children have participated. They all completed the neurological and blood tests before and after the intervention. In the first 2 weeks, vitamin B6 was given in doses of 5mg/kg. In the following 2 weeks, vitamin B6 was given in doses of 10mg/kg. Among the participants, 3 cases were judged as "effective". We compared the characteristics and biomarkers between "effective" group and "ineffective" group. We found that simultaneously having "hypersensitivity to sound" and "clumsiness" or "low plasma concentration of glutamine" predicted the vitamin B6 responsiveness.
緑茶カテキン摂取が血中アディポネクチン値に与える影響 : ランダム化比較試験

栗山進一, 藤田和樹, 中谷直樹

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 萌芽研究

Institution: 東北大学

2007 - 2008

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本研究の目的は、緑茶に含まれるカテキン摂取が血中アディポネクチン値に与える影響をランダム化比較試験により検討することである。試験参加者は20〜79歳の男女、既往歴にがん、心筋梗塞、脳血管疾患、腎疾患のない者である。平成18年6月・12月の仙台市健康増進センター減量チャレンジ講座に合わせ、講座参加者及び職員から募集を行い、51名(講座参加者31名、非参加者20名)を特定した。参加者は性(男性、女性)、減量チャレンジ講座(参加、非参加)別に無作為化され、介入群25名、対照群26名に割り付けられた。介入は介入前2週間の緑茶摂取中止を求め、その後、介入群は緑茶カテキン400mg含有飲料500mlを9週間飲用、対照群は緑茶カテキン100mg含有飲料500mlを9週間飲用した。主要効果指標として、血中アディポネクチン値を介入の前後で比較した。ベースライン時の血中アディポネクチン値は介入群より対照群で、有意ではないが高い値を示した(介入群8.23μg/ml、対照群8.79μg/ml)。9週間の介入後、血中アディポネクチン値は両群ともに有意に上昇したが(介入群1.29μg/ml上昇、対照群1.00μg/ml上昇)、群間における変化の差は有意ではなかった[0.35μg/ml(95% CI ; -1.03, 1.74)]。副次的指標において、体重、BMI、ウエスト周囲径は、介入群・対照群の両群で介入後有意に減少したが、群間における変化の差は有意ではなかった。追加解析として、血中アディポネクチン値について性別、減量チャレンジ講座別に層別化解析を実施した。血中アディポネクチン値は男性、女性ともに、群間における変化の差は有意ではなかった[男性 : 0.52μg/ml(95% Cl ; -1.71, 2.76)、女性 : 0.34μg/ml(95% Cl ; -1.55, 2.22)]。同様に、減量チャレンジ講座参加者、非参加者ともに、群間における変化の差は有意ではなかった[参加者 : 0.15 μg/ml(95% Cl ; -1.54, 1.85)、非参加者 : 1.49μg/ml(95% Cl ; -0.46, 3.43)]。以上のランダム化比較試験より、緑茶カテキン摂取による血中アディポネクチン値の有意な上昇は示されなかった。
Development of a tailor-made individual life-style intervention programs for prevention of type 2 diabetes mellitus

KURIYAMA Shiinichi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2005 - 2006

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We firstly compared the effectiveness of intensive and moderate intervention, focusing on the frequency of individual educational classes. The subjects were men and women aged 44-69 years living in Japan. We assigned the subjects according to their residences to an intensive life-style intervention group (two education classes per month; n=11) or a moderate intervention group (one education class per month; n=14). After 6 months of intervention, the loss of body weight was-3.5 kg (p<.0001) in the intensive intervention group and-1.8 kg (p=0.02) in the moderate group, and the net difference in body weight loss between the groups was-2.0 kg (95% confidence interval (CI);-4.0 to-0.05; p=0.045). Secondly, we compared the changes of body weight and plasma glucose concentration between carriers and noncarriers of the Trp64Arg polymorphism in the 83-adrenergic receptor gene before and after weight loss interventions. A total of 37 persons (12 carriers and 25 noncarriers for the Trp64Arg polymorphism) participated in the study. There were no differences in body weight or plasma glucose concentration between the two groups at baseline. There were significant reductions in body weight and plasma glucose concentration, when analyzed with the two genotypes combined, but no significant differences between carriers and noncarriers with respect to changes in these variables. The weight change was-2.5 kg (95% CI;-3.6,-1.3) among carriers and-1.9 kg (95% CI;-2.7,-1.1) among noncarriers. The corresponding figures in fasting plasma glucose concentration were-3.9 mg/dl (95% CI;-8.4, 0.6) and-0.2 mg/d1 (95% CI;-3.3, 2.9), respectively. These results suggest that the presence of the Trp64Arg polymorphism may not play a major role in a hindrance to weight reduction, while intensive intervention could produce better results even if the genetic backgrounds were not considered.
血中8-イソプロスタン値とがん罹患に関する前向きコーホート研究

栗山進一

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特定領域研究

Institution: 東北大学

2004 - 2004

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8-イソプロスタンは生体内酸化ストレス状態のバイオマーカーである。2002年に実施した仙台市鶴ヶ谷地区在住高齢者(70歳以上)を対象とする総合的心身機能評価(Comprehensive Geriatric Assessment : CGA)参加者で追跡調査可能な者(国民健康保険加入者)を対象に、研究に際して測定された血中8-イソプロスタン値とがん罹患との関連を、採録調査による追跡調査にもとづき検討した。890名を2年間追跡し、総観察人年1713.9人年で38例のがん罹患を観察した。血中8-イソプロスタン値によって対象者を3群に分け、低値群を基準とし、Cox比例ハザードモデルを用いて各群の相対危険度を算出した。性、年齢、body mass index、糖尿病、高血圧、非食事性抗酸化物質の摂取、喫煙、飲酒、自己健康感、身体機能を補正した全がん罹患に関する相対危険度(95%信頼区間)は、8-イソプロスタン低値群を基準とすると、8-イソプロスタン中間群では0.79(0.36-1.72)、8-イソプロスタン高値群では0.42(0.18-1.00)(傾向性のP値=0.049)と統計学的に有意な負の関連がみられた。以上の結果から、血中8-イソプロスタン値は、がんリスク予測バイオマーカーとしてその低値が意義を持つことになる可能性が示唆されたが、がん罹患総数38例であるためこの結果が偶然である可能性は否定できない。

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Social Activities 32

掛川市

2012/11/17 - 2012/11/18

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第66回全国お茶まつり静岡大会
東北メディカル・メガバンク機構

2014/04/26 -

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アトピー性皮膚炎の症状と治療（岩沼市中央公民館視聴覚室）プログラム１．震災後に増えた子供の疾患とその対策-「宮城健勝/中学生の健康アンケート調査」の結果より栗山進一２．アトピー性皮膚炎の症状と治療について〜家庭でできることから始めましょう〜皮膚科学分野非常勤講師小澤麻紀
石巻市

2014/02/28 -

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子どもの健康なからだづくりを考えよう〜石巻地区のメタボ予防〜（石巻市）宮城県石巻合同庁舎「子どもの健康な“からだ”づくり・“こころ”づくりを進めるために」
九州大学食品機能デザイン研究センター

2014/01/11 -

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「緑茶疫学研究の最前線と今後の展望」福岡市九州大学留学生センター国際ホール
宮城県国保連合会

2013/12/02 -

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第２回市町村国保(国保組合)・保健関係者研修会（仙台市）ホテル法華クラブ仙台「肥満と闘おう〜明日の笑顔のために〜」
東京医科歯科大学難治疾患研究所・国立環境研究所

2013/11/23 -

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東京医科歯科大学難治疾患研究所・国立環境研究所共催シンポジウム「発達障害研究の最前線」（東京都）東京医科歯科大学M&Dタワー「東北メディカル・メガバンクにおける発達障害研究」
宮城県医師会医師研修講習会

2013/07/06 -

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平成25年度「宮城県医師会医師研修講習会」（仙南地区）（角田市）仙南シンケンファクトリー「東北メディカル・メガバンク機構の活動について」
日本消化器がん検診学会

2013/06/08 -

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第52回日本消化器がん検診学会総会研修会及び市民公開講座（仙台市）仙台国際センター「がんの危険を減らす確実な方法とあなたに最適ながん予防法」
サイエンスカフェ

2013/04/26 -

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「人は分子の集合体か」
黒川地区地域医療対策委員会

2013/02/08 -

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「成人/高齢者保健医療福祉事業の推進及び産業保健との連携部会」
独）国立国際医療研究センター

2012/11/16 -

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第1回NCGM国際シンポジウム「バイオバンクの意義と国内外の動向」
生命医薬情報学連合大会

2012/10/16 -

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セッション
[日本国内] 肥満体質でもやせられる

2008/11/09 -

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遺伝子変異の有無減量に差なし
[日本国内] 平成18年度保健師研修

2007/11 -

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新たな生活習慣病対策と保健指導について〜ポピュレーション・アプローチのエビデンス〜
[日本国内] 第22回茶学術研究会講演会

2007/03 -

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緑茶摂取と認知機能に関する横断研究
[日本国内] 平成18年度調理師研修会

2006/11 -

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メタボリックシンドロームと食生活について〜氾濫する健康情報と肥満が健康に与える影響〜
[日本国内] 第12回東北老年医療シンポジウム

2006/10 -

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食事と認知症
[日本国内] 緑茶好きは長生きさん

2006/09 -
[日本国内] 動脈硬化に緑茶効果

2006/09 -
[海外・国際] Green tea may lives, researchers find

2006/09 -
[海外・国際] Green tea cuts fatal illness risk

2006/09 -
[海外・国際] Green Tea: Mixed Review As Health Aid

2006/09 -
[海外・国際] Green tea may lengthen life span

2006/09 -
[日本国内] 緑茶「長生き効果」、研究チーム確認がんは差なし

2006/09 -
[日本国内] 毎日5杯、緑茶で長寿...脳こうそく死亡率が大幅低下

2006/09 -
[日本国内] 仙台元気塾

2006/08 -

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生活習慣病の予防について〜喫煙とメタボリックシンドローム〜
[日本国内] 名取市農業者年金加入者協議会30周年記念講演

2006/07 -

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中高年、生活習慣病予防のコツ
[日本国内] 第3回カテキン学会

2006/06 -

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1日2杯の緑茶が認知症を予防する可能性
[日本国内] 栗原栄養士会総会ならびに研修会・講和

2006/05 -

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メタボリックシンドローム〜氾濫する健康情報と肥満が健康に与える影響〜
[日本国内] 緑茶で認証予防

2006/03/05 -
[日本国内] 1日２杯上飲む人週３杯以下より記憶力衰えにくい

2006/03/02 -
[海外・国際] Green tea may protect the aging brain

2006/02 -

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Media Coverage 10

NHK ラジオ第一（宮城県域）『ゴジだっちゃ！』「気になるニュース」

NHKラジオ第一

2014/01/30

Type: Other

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NHK ラジオ第一（宮城県域）『ゴジだっちゃ！』「気になるニュース」東北メディカル・メガバンク事業「地域子ども長期健康調査」の結果について解説
科学の泉

河北新報

2013/11/17

Type: Newspaper, magazine

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次世代の病気予防法⑥ 全人的医療の実現目指す
科学の泉

河北新報

2013/11/16

Type: Newspaper, magazine

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次世代の病気予防法⑤ 医師、患者、家族の協力必要
科学の泉

河北新報

2013/11/15

Type: Newspaper, magazine

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次世代の病気予防法④ 社会的要員の発病研究進む
科学の泉

河北新報

2013/11/14

Type: Newspaper, magazine

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次世代の病気予防法③ 遺伝要因の治療例徐々に蓄積
科学の泉

河北新報

2013/11/13

Type: Newspaper, magazine

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次世代の病気予防法② 体質考え生活見直そう
科学の泉

河北新報

2013/11/12

Type: Newspaper, magazine

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次世代の病気予防法①禁煙や食生活今と変わらず
河北新報・東北大東北未来プロジェクトサイエンスカフェ

河北新報

2013/05/08

Type: Newspaper, magazine

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4/26開催のサイエンスカフェ「人は分子の集合体か〜遺伝・環境・社会的要員の全てを考慮した全人的医療〜」について
[日本国内] 生涯医療費肥満の人は高い

NHK

2009/04/24

Type: TV or radio program
[日本国内] 緑茶と認知症

日経ヘルス

2006/04

Type: Newspaper, magazine

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Other 33

個人に適した効果的な摂取条件等を特定する手法の開発及び摂取条件等を普及するためのモデル体制の構築（茶）

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個人に適した効果的な摂取条件等を特定する手法の開発及び摂取条件等を普及するためのモデル体制の構築（茶）
シトリン欠損症患者における臨床像の多様性の解明と致死的脳症の発症予防法の開発

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シトリン欠損症患者における臨床像の多様性の解明と致死的脳症の発症予防法の開発
低出生体重児の予後及び保健的介入並びに妊婦及び乳幼児の体格の疫学的調査手法に関する研究

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低出生体重児の予後及び保健的介入並びに妊婦及び乳幼児の体格の疫学的調査手法に関する研究
東日本大震災被災地の小児保健に関する調査研究

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成育疾患克服等次世代育成基盤研究事業東日本大震災被災地の小児保健に関する調査研究
環境省・こどもの健康と環境に関する全国調査における血中アミノ酸測定とその解析

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環境省・こどもの健康と環境に関する全国調査における血中アミノ酸測定とその解析
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多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究
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妊婦における医療用医薬品の安全性に関するエビデンスの構築のための薬剤疫学研究の基盤整備および実践
緑茶のもつ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発（農水課題番号：21028）

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緑茶のもつ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発（農水課題番号：21028）
コホート研究における血中アミノ酸測定とその解析

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コホート研究における血中アミノ酸測定とその解析
がんの原因究明と本態解明に資する新たな分子疫学コホート研究の構築に向けた研究計画の立案

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がんの原因究明と本態解明に資する新たな分子疫学コホート研究の構築に向けた研究計画の立案
緑茶のもつ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発

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緑茶のもつ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発
コステロ症候群・CFC症候群類縁疾患の診断基準作成と治療薬

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コステロ症候群・CFC症候群類縁疾患の診断基準作成と治療薬
分子診断に基づくヌーナン症候群の診断基準の作成と新規病因遺伝子の探索

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分子診断に基づくヌーナン症候群の診断基準の作成と新規病因遺伝子の探索
緑茶の持つ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発

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緑茶の持つ生活習慣病改善効果の検証と効果的な摂取を可能にする新食品の開発
コステロ症候群・ＣＦＣ症候群類縁疾患の診断基準作成と治療法開発に関する研究

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コステロ症候群・ＣＦＣ症候群類縁疾患の診断基準作成と治療法開発に関する研究
ゲノムインプリンティング異常症５疾患の実態把握に関する全国他施設共同研究

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ゲノムインプリンティング異常症５疾患の実態把握に関する全国他施設共同研究
受診率につながるがん検診の在り方や、普及啓発の方法の開発等に関する研究

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受診率につながるがん検診の在り方や、普及啓発の方法の開発等に関する研究
飲料摂取とがんに関する研究助成金

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飲料摂取とがんに関する研究助成金
受診率向上につながるがん検診の在り方や、普及啓発の方法の開発等に関する研究

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受診率向上につながるがん検診の在り方や、普及啓発の方法の開発等に関する研究
American Journal of Clinical Nutrition の査読委員
日本衛生学雑誌の査読委員
Yonsei Medical Journal の査読委員
Tohoku Journal of Experimental Medicine の査読委員
International Journal of Obesity の査読委員
International Journal of Cancer の査読委員
JAMA の査読委員
Stroke の査読委員
European Journal of Clinical Nutrition の査読委員
British Medical Journal の査読委員
International Journal of Geriatric Psychiatry の査読委員
乳がん検診の精度及び効率の向上に関する研究

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乳がん検診の精度及び効率の向上に関する研究
Hypertension Research の査読委員
Journal of Epidemiology の査読委員

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