TOHOKU UNIVERSITY Researchers - Takahiro Shintani

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Takahiro Shintani

Section

Graduate School of Agricultural Science

Job title

Professor

Degree

博士（農学）（東北大学）
修士（農学）（東北大学）

researchmap

https://researchmap.jp/read0116692

J-GLOBAL ID

200901017852789814

Research History 6

2004/06 - Present

東北大学大学院農学研究科
2006/09 - 2007/03

Life Sciences Institute, University of Michigan
2001/06 - 2004/05

Department of Molecular, Cellular and Developmental Biology, University of Michigan　Postdoctoral research fellow
2001/04 - 2001/05

National Institute for Basic Biology　Research associate
1998/04 - 2001/03

National Institute for Basic Biology　Research Fellow of the Japan Society for the Promotion of Science
1996/04 - 1998/03

Fuculty of Agriculture, Tohoku University　Research Fellow of the Japan Society for the Promotion of Science

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Education 2

Tohoku University　Graduate School of Agricultural Science　Agricultural Chemistry

- 1997/03
Tohoku University　Faculty of Agriculture　Agricultural Chemistry

- 1991/03/25

Committee Memberships 19

糸状菌分子生物学研究会　運営委員（庶務担当）

2021/07 - Present
日本農芸化学会東北支部　代議員（宮城県）

2024/04 - 2026/03
公益財団法人翠生農学振興会　理事

2023/06 - 2025/05
文部科学省科学技術・学術政策研究所科学技術予測・政策基盤調査研究センター　令和6年度専門調査員

2024/04 - 2025/03
公益財団法人翠生農学振興会　理事

2021/06 - 2023/05
国立大学法人東北大学ビジネス・インキュベーション・プログラム/国際出願審査委員会　審査委員

2021/04 - 2022/03
日本農芸化学会2021年度大会実行委員会　委員

2020/03 - 2022/02
糸状菌分子生物学研究会　運営委員

2017/07 - 2021/06
日本農芸化学会　和文誌編集委員

2017/03 - 2019/02
科学研究費委員会　専門委員

2016/12 - 2017/11
日本農芸化学会　和文誌編集委員

2015/03 - 2017/02
糸状菌分子生物学コンファレンス　実行委員

2014/09 - 2014/11
日本農芸化学会　東北支部選挙管理委員会委員

2013/09 - 2014/11
酵母遺伝学フォーラム　第46回研究報告会実行委員

2013/04 - 2013/09
日本農芸化学会2013年度仙台大会　大会実行委員

2012/04 - 2013/03
日本生物工学会北日本支部　庶務幹事

2011/04 - 2013/03
日本農芸化学会東北支部　幹事（会員）

2009/04 - 2011/03
日本農芸化学会　第二期産学官若手交流会メンバー

2005/06 - 2007/03
日本農芸化学会東北支部　会員幹事

2005/04 - 2007/03

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Professional Memberships 5

日本生物工学会
酵母遺伝学フォーラム
糸状菌分子生物学研究会
The Molecular Biology Society of Japan
Japan Society for Bioscience, Biotechnology, and Agrochemistry

Research Interests 6

transporter
koji mold
protein production
yeast
eukaryotic microbe
intracellular trafficking

Research Areas 4

Life sciences / Applied molecular and cellular biology /
Life sciences / Cell biology /
Life sciences / Molecular biology /
Life sciences / Applied microbiology /

Papers 62

Glucose-induced endocytic degradation of the maltose transporter MalP is mediated through ubiquitination by the HECT-ubiquitin ligase HulA and its adaptor CreD in Aspergillus oryzae Peer-reviewed

Shoki Fujita, Hinako Tada, Yuka Matsuura, Tetsuya Hiramoto, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

Fungal Genetics and Biology　173　103909　2024/08
Publisher: Elsevier BV
DOI： 10.1016/j.fgb.2024.103909 　

ISSN： 1087-1845
Ykt6 functionally overlaps with vacuolar and exocytic R-SNAREs in the yeast Saccharomyces cerevisiae Peer-reviewed

Hayate Watanabe, Shingo Urano, Nozomi Kikuchi, Yurika Kubo, Ayumi Kikuchi, Katsuya Gomi, Takahiro Shintani

Journal of Biological Chemistry　107274-107274　2024/04
Publisher: Elsevier BV
DOI： 10.1016/j.jbc.2024.107274 　

ISSN： 0021-9258
Construction of self-cloning Aspergillus oryzae strains with high production of multiple biomass-degrading enzymes on solid-state culture Peer-reviewed

Satoko Senoo, Tomoko Shintani, Shoko Nieda, Takahiro Shintani, Masahiro Kariyama, Katsuya Gomi

Journal of Bioscience and Bioengineering　137　(3)　204-210　2024/03
Publisher: Elsevier BV
DOI： 10.1016/j.jbiosc.2023.12.005 　

ISSN： 1389-1723
Physiological ER stress caused by amylase production induces regulated Ire1-dependent mRNA decay in Aspergillus oryzae. International-journal Peer-reviewed

Mizuki Tanaka, Silai Zhang, Shun Sato, Jun-Ichi Yokota, Yuko Sugiyama, Yasuaki Kawarasaki, Youhei Yamagata, Katsuya Gomi, Takahiro Shintani

Communications biology　6　(1)　1009　2023/10/04

DOI： 10.1038/s42003-023-05386-w 　

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Regulated Ire1-dependent decay (RIDD) is a feedback mechanism in which the endoribonuclease Ire1 cleaves endoplasmic reticulum (ER)-localized mRNAs encoding secretory and membrane proteins in eukaryotic cells under ER stress. RIDD is artificially induced by chemicals that generate ER stress; however, its importance under physiological conditions remains unclear. Here, we demonstrate the occurrence of RIDD in filamentous fungus using Aspergillus oryzae as a model, which secretes copious amounts of amylases. α-Amylase mRNA was rapidly degraded by IreA, an Ire1 ortholog, depending on its ER-associated translation when mycelia were treated with dithiothreitol, an ER-stress inducer. The mRNA encoding maltose permease MalP, a prerequisite for the induction of amylolytic genes, was also identified as an RIDD target. Importantly, RIDD of malP mRNA is triggered by inducing amylase production without any artificial ER stress inducer. Our data provide the evidence that RIDD occurs in eukaryotic microorganisms under physiological ER stress.
Improved recombinant protein production in Aspergillus oryzae lacking both α-1,3-glucan and galactosaminogalactan in batch culture with a lab-scale bioreactor Peer-reviewed

Hikaru Ichikawa, Ken Miyazawa, Keisuke Komeiji, Shunya Susukida, Silai Zhang, Kiyoaki Muto, Ryutaro Orita, Ayumu Takeuchi, Yuka Kamachi, Masahiro Hitosugi, Akira Yoshimi, Takahiro Shintani, Yoshikazu Kato, Keietsu Abe

Journal of Bioscience and Bioengineering　85　39-45　2022/01
Publisher: Elsevier BV
DOI： 10.1016/j.jbiosc.2021.09.010 　

ISSN： 1389-1723
Crucial role of the intracellular α-glucosidase MalT in the activation of the transcription factor AmyR essential for amylolytic gene expression in Aspergillus oryzae. International-journal Peer-reviewed

Takanori Ichikawa, Mizuki Tanaka, Takayasu Watanabe, Sitong Zhan, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

Bioscience, Biotechnology, and Biochemistry　85　(9)　2076-2083　2021/07/10

DOI： 10.1093/bbb/zbab125 　

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We examined the role of the intracellular α-glucosidase gene malT, which is part of the maltose-utilizing cluster (MAL cluster) together with malR and malP, in amylolytic gene expression in Aspergillus oryzae. malT disruption severely affected fungal growth on medium containing maltose or starch. Furthermore, the transcription level of the α-amylase gene was significantly reduced by malT disruption. Given that the transcription factor AmyR responsible for amylolytic gene expression is activated by isomaltose converted from maltose incorporated into the cells, MalT may have transglycosylation activity that converts maltose to isomaltose. Indeed, transglycosylated products such as isomaltose/maltotriose and panose were generated from the substrate maltose by MalT purified from a malT-overexpressing strain. The results of this study, taken together, suggests that MalT plays a pivotal role in AmyR activation via its transglycosylation activity that converts maltose to the physiological inducer isomaltose.
Expression profiles of amylolytic genes in AmyR and CreA transcription factor deletion mutants of the black koji mold Aspergillus luchuensis. Peer-reviewed

Wataru Hashimoto, Hiraku Arai, Osamu Mizutani, Osamu Yamada, Takahiro Shintani, Katsuya Gomi

Journal of bioscience and bioengineering　132　(4)　321-326　2021/06/24

DOI： 10.1016/j.jbiosc.2021.06.003 　

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The black koji mold, Aspergillus luchuensis, which belongs to Aspergillus section Nigri, is used for the production of traditional Japanese spirits (shochu) mainly in the southern districts of Japan. This mold is known to produce amylolytic enzymes essential for shochu production; however, mechanisms regulating amylolytic gene expression in A. luchuensis have not been studied in as much detail as those in the yellow koji mold, Aspergillus oryzae. Here, we examined the gene expression profiles of deletion mutants of transcription factors orthologous to A. oryzae AmyR and CreA in A. luchuensis. A. luchuensis produces acid-unstable (AmyA) and acid-stable (AsaA) α-amylases. AmyA production and amyA gene expression were not influenced by amyR or creA deletion, indicating that amyA was constitutively expressed. In contrast, asaA gene expression was significantly down- and upregulated upon deletion of amyR and creA, respectively. Furthermore, the glaA and agdA genes (encoding glucoamylase and α-glucosidase, respectively) showed expression profiles similar to those of asaA. Thus, genes that play pivotal roles in starch saccharification, asaA, glaA, and agdA, were found to be regulated by AmyR and CreA. Moreover, despite previous reports on AsaA being only produced in solid-state culture, deletion of the ortholog of A. oryzae flbC, which is involved in the expression of the solid-state culture-specific genes, did not affect AsaA α-amylase activity, suggesting that FlbC was not associated with asaA expression.
Enzymatic degradation of xyloglucans by Aspergillus species: a comparative view of this genus. International-journal

Tomohiko Matsuzawa, Akira Watanabe, Takahiro Shintani, Katsuya Gomi, Katsuro Yaoi

Applied microbiology and biotechnology　105　(7)　2701-2711　2021/04

DOI： 10.1007/s00253-021-11236-8 　

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Aspergillus species are closely associated with humanity through fermentation, infectious disease, and mycotoxin contamination of food. Members of this genus produce various enzymes to degrade plant polysaccharides, including starch, cellulose, xylan, and xyloglucan. This review focus on the machinery of the xyloglucan degradation using glycoside hydrolases, such as xyloglucanases, isoprimeverose-producing oligoxyloglucan hydrolases, and α-xylosidases, in Aspergillus species. Some xyloglucan degradation-related glycoside hydrolases are well conserved in this genus; however, other enzymes are not. Cooperative actions of these glycoside hydrolases are crucial for xyloglucan degradation in Aspergillus species. KEY POINTS: •Xyloglucan degradation-related enzymes of Aspergillus species are reviewed. •Each Aspergillus species possesses a different set of glycoside hydrolases. •The machinery of xyloglucan degradation of A. oryzae is overviewed.
Alternative transcription start sites of the enolase-encoding gene enoA are stringently used in glycolytic/gluconeogenic conditions in Aspergillus oryzae. International-journal Peer-reviewed

Taishi Inoue, Hiroki Toji, Mizuki Tanaka, Mitsuru Takama, Sachiko Hasegawa-Shiro, Yuichi Yamaki, Takahiro Shintani, Katsuya Gomi

Current genetics　66　(4)　729-747　2020/02/18

DOI： 10.1007/s00294-020-01053-3 　

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Gene expression using alternative transcription start sites (TSSs) is an important transcriptional regulatory mechanism for environmental responses in eukaryotes. Here, we identify two alternative TSSs in the enolase-encoding gene (enoA) in Aspergillus oryzae, an industrially important filamentous fungus. TSS use in enoA is strictly dependent on the difference in glycolytic and gluconeogenic carbon sources. Transcription from the upstream TSS (uTSS) or downstream TSS (dTSS) predominantly occurs under gluconeogenic or glycolytic conditions, respectively. In addition to enoA, most glycolytic genes involved in reversible reactions possess alternative TSSs. The fbaA gene, which encodes fructose-bisphosphate aldolase, also shows stringent alternative TSS selection, similar to enoA. Alignment of promoter sequences of enolase-encoding genes in Aspergillus predicted two conserved regions that contain a putative cis-element required for enoA transcription from each TSS. However, uTSS-mediated transcription of the acuN gene, an enoA ortholog in Aspergillus nidulans, is not strictly dependent on carbon source, unlike enoA. Furthermore, enoA transcript levels in glycolytic conditions are higher than in gluconeogenic conditions. Conversely, acuN is more highly transcribed in gluconeogenic conditions. This suggests that the stringent usage of alternative TSSs and higher transcription in glycolytic conditions in enoA may reflect that the A. oryzae evolutionary genetic background was domesticated by exclusive growth in starch-rich environments. These findings provide novel insights into the complexity and diversity of transcriptional regulation of glycolytic/gluconeogenic genes among Aspergilli.
Nuclear export-dependent degradation of the carbon catabolite repressor CreA is regulated by a region located near the C-terminus in Aspergillus oryzae. International-journal Peer-reviewed

Tanaka M, Ichinose S, Shintani T, Gomi K

Molecular Microbiology　110　(2)　176-190　2018/10

DOI： 10.1111/mmi.14072 　

ISSN： 0950-382X

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Carbon catabolite repression (CCR) is regulated by the C2 H2 -type transcription factor CreA/Cre1 in filamentous fungi including Aspergillus oryzae. We investigated the stability and subcellular localization of CreA in A. oryzae. The abundance of FLAG-tagged CreA (FLAG-CreA) was dramatically reduced after incubation in maltose and xylose, which stimulated the export of CreA from the nucleus to the cytoplasm. Mutation of a putative nuclear export signal resulted in nuclear retention and significant stabilization of CreA. These results suggest that CreA is rapidly degraded in the cytoplasm after export from the nucleus. The FLAG-CreA protein level was reduced by disruption of creB and creC, which encode the deubiquitinating enzyme complex involved in CCR. In contrast, FLAG-CreA stability was not affected by disruption of creD which encodes an arrestin-like protein required for CCR relief. Deletion of the last 40 C-terminal amino acids resulted in remarkable stabilization and increased abundance of FLAG-CreA, whereas deletion of the last 20 C-terminal amino acids had no apparent effect on CreA stability. This result suggests that the 20 amino acid region located between positions 390 and 409 of CreA is critical for the rapid degradation of CreA.
The PDR-type ABC transporters AtrA and AtrG are involved in azole drug resistance in Aspergillus oryzae. International-journal Peer-reviewed

Miura D, Sugiyama K, Ito A, Ohba-Tanaka A, Tanaka M, Shintani T, Gomi K

Bioscience, Biotechnology, and Biochemistry　82　(10)　1840-1848　2018/10

DOI： 10.1080/09168451.2018.1497941 　

ISSN： 0916-8451

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For strain improvement of Aspergillus oryzae, development of the transformation system is essential, wherein dominant selectable markers, including drug-resistant genes, are available. However, A. oryzae generally has a relatively high resistance to many antifungal drugs effective against yeasts and other filamentous fungi. In the course of the study, while investigating azole drug resistance in A. oryzae, we isolated a spontaneous mutant that exhibited high resistance to azole fungicides and found that pleiotropic drug resistance (PDR)-type ATP-binding cassette (ABC) transporter genes were upregulated in the mutant; their overexpression in the wild-type strain increased azole drug resistance. While deletion of the gene designated atrG resulted in increased azole susceptibility, double deletion of atrG and another gene (atrA) resulted in further azole hypersensitivity. Overall, these results indicate that the ABC transporters AtrA and AtrG are involved in azole drug resistance in A. oryzae.
The C-terminal region of the yeast monocarboxylate transporter Jen1 acts as a glucose signal-responding degron recognized by the α-arrestin Rod1. Peer-reviewed

Fujita S, Sato D, Kasai H, Ohashi M, Tsukue S, Takekoshi Y, Gomi K, Shintani T

The Journal of Biological Chemistry　293　10926-10936　2018/07

DOI： 10.1074/jbc.RA117.001062 　

ISSN： 0021-9258
Increased production of biomass-degrading enzymes by double deletion of creA and creB genes involved in carbon catabolite repression in Aspergillus oryzae Peer-reviewed

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

Journal of Bioscience and Bioengineering　125　(2)　141-147　2018/02/01
Publisher: Elsevier B.V.
DOI： 10.1016/j.jbiosc.2017.08.019 　

ISSN： 1347-4421 1389-1723
Chaperone complex formation of the transcription factor MalR involved in maltose utilization and amylolytic enzyme production in Aspergillus oryzae Peer-reviewed

Yui Konno, Kuta Suzuki, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

Bioscience, Biotechnology and Biochemistry　82　(5)　827-835　2018
Publisher: Japan Society for Bioscience Biotechnology and Agrochemistry
DOI： 10.1080/09168451.2018.1447359 　

ISSN： 1347-6947 0916-8451
Subcellular localization of aphidicolin biosynthetic enzymes heterologously expressed in Aspergillus oryzae Peer-reviewed

Akihiko Ban, Mizuki Tanaka, Ryuya Fujii, Atsushi Minami, Hideaki Oikawa, Takahiro Shintani, Katsuya Gomi

Bioscience, Biotechnology and Biochemistry　82　(1)　139-147　2018
Publisher: Japan Society for Bioscience Biotechnology and Agrochemistry
DOI： 10.1080/09168451.2017.1399789 　

ISSN： 1347-6947 0916-8451
Cell wall alpha-1,3-glucan prevents alpha-amylase adsorption onto fungal cell in submerged culture of Aspergillus oryzae Peer-reviewed

Silai Zhang, Hiroki Sato, Sakurako Ichinose, Mizuki Tanaka, Ken Miyazawa, Akira Yoshimi, Keietsu Abe, Takahiro Shintani, Katsuya Gomi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　124　(1)　47-53　2017/07

DOI： 10.1016/j.jbiosc.2017.02.013 　

ISSN： 1389-1723

eISSN： 1347-4421
Improved alpha-Amylase Production by Dephosphorylation Mutation of CreD, an Arrestin-Like Protein Required for Glucose-Induced Endocytosis of Maltose Permease and Carbon Catabolite Derepression in Aspergillus oryzae Peer-reviewed

Mizuki Tanaka, Tetsuya Hiramoto, Hinako Tada, Takahiro Shintani, Katsuya Gomi

APPLIED AND ENVIRONMENTAL MICROBIOLOGY　83　(13)　UNSP e00592　2017/07

DOI： 10.1128/AEM.00592-17 　

ISSN： 0099-2240

eISSN： 1098-5336
Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae Peer-reviewed

Silai Zhang, Akihiko Ban, Naoki Ebara, Osamu Mizutani, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　123　(4)　403-411　2017/04

DOI： 10.1016/j.jbiosc.2016.11.001 　

ISSN： 1389-1723

eISSN： 1347-4421
Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae Peer-reviewed

Jun-ichi Yokota, Daisuke Shiro, Mizuki Tanaka, Yasumichi Onozaki, Osamu Mizutani, Dararat Kakizono, Sakurako Ichinose, Tomoko Shintani, Katsuya Gomi, Takahiro Shintani

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　101　(6)　2437-2446　2017/03

DOI： 10.1007/s00253-016-8086-3 　

ISSN： 0175-7598

eISSN： 1432-0614
Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases Peer-reviewed

Daisuke Takahashi, Yuki Orihara, Saho Kitagawa, Masayuki Kusakabe, Takahiro Shintani, Yukako Oma, Masahiko Harata

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　81　(8)　1557-1560　2017

DOI： 10.1080/09168451.2017.1326087 　

ISSN： 0916-8451

eISSN： 1347-6947
A Novel Zn-2-Cys(6) Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Coregulating cyp51A and cdr1B Expressions Peer-reviewed

Daisuke Hagiwara, Daisuke Miura, Kiminori Shimizu, Sanjoy Paul, Ayumi Ohba, Tohru Gonoi, Akira Watanabe, Katsuhiko Kamei, Takahiro Shintani, W. Scott Moye-Rowley, Susumu Kawamoto, Katsuya Gomi

PLOS PATHOGENS　13　(1)　e1006096　2017/01

DOI： 10.1371/journal.ppat.1006096 　

ISSN： 1553-7366

eISSN： 1553-7374
Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae Peer-reviewed

Hiroto Yokota, Katsuya Gomi, Takahiro Shintani

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　483　(1)　522-527　2017/01

DOI： 10.1016/j.bbrc.2016.12.112 　

ISSN： 0006-291X

eISSN： 1090-2104
The C2H2-type transcription factor, FlbC, is involved in the transcriptional regulation of Aspergillus oryzae glucoamylase and protease genes specifically expressed in solid-state culture Peer-reviewed

Mizuki Tanaka, Midori Yoshimura, Masahiro Ogawa, Yasuji Koyama, Takahiro Shintani, Katsuya Gomi

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　100　(13)　5859-5868　2016/07

DOI： 10.1007/s00253-016-7419-6 　

ISSN： 0175-7598

eISSN： 1432-0614
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). International-journal Peer-reviewed

Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu-Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong-Hun Bae, Jae-Sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R Beck Jr, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrends, Georg Mn Behrens, Kevin E Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie-Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania Mm Braga, Claudio Brancolini, Gerhard H Braus, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brookes, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, 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Xu Dong Zhang, Yan Zhang, Yang Zhang, Yanjin Zhang, Yingmei Zhang, Yunjiao Zhang, Mei Zhao, Wei-Li Zhao, Xiaonan Zhao, Yan G Zhao, Ying Zhao, Yongchao Zhao, Yu-Xia Zhao, Zhendong Zhao, Zhizhuang J Zhao, Dexian Zheng, Xi-Long Zheng, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Guang-Zhou Zhou, Guofei Zhou, Huiping Zhou, Shu-Feng Zhou, Xu-Jie Zhou, Hongxin Zhu, Hua Zhu, Wei-Guo Zhu, Wenhua Zhu, Xiao-Feng Zhu, Yuhua Zhu, Shi-Mei Zhuang, Xiaohong Zhuang, Elio Ziparo, Christos E Zois, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Susu M Zughaier

Autophagy　12　(1)　1-222　2016

DOI： 10.1080/15548627.2015.1100356 　
Purification and enzymatic characterization of secretory glycoside hydrolase family 3 (GH3) aryl beta-glucosidases screened from Aspergillus oryzae genome Peer-reviewed

Kanako Kudo, Akira Watanabe, Seiryu Ujiie, Takahiro Shintani, Katsuya Gomi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　120　(6)　614-623　2015/12

DOI： 10.1016/j.jbiosc.2015.03.019 　

ISSN： 1389-1723

eISSN： 1347-4421
Unfolded protein response is required for Aspergillus oryzae growth under conditions inducing secretory hydrolytic enzyme production Peer-reviewed

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

FUNGAL GENETICS AND BIOLOGY　85　1-6　2015/12

DOI： 10.1016/j.fgb.2015.10.003 　

ISSN： 1087-1845

eISSN： 1096-0937
Endocytosis of a maltose permease is induced when amylolytic enzyme production is repressed in Aspergillus oryzae Peer-reviewed

Tetsuya Hiramoto, Mizuki Tanaka, Takanori Ichikawa, Yuka Matsuura, Sachiko Hasegawa-Shiro, Takahiro Shintani, Katsuya Gomi

FUNGAL GENETICS AND BIOLOGY　82　136-144　2015/09

DOI： 10.1016/j.fgb.2015.05.015 　

ISSN： 1087-1845

eISSN： 1096-0937
Non-selective autophagy induced by phosphate starvation requires Atg11 and Is regulated by TORC1 signaling pathway in Saccharomyces cerevisiae Peer-reviewed

Hiroto Yokota, Katsuya Gomi, Takahiro Shintani

YEAST　32　S203-S203　2015/09

ISSN： 0749-503X

eISSN： 1097-0061
Identification of regions in monocarboxylic acid transporter Jen1 requisite for its glucose-induced degradation and recognition by arrestin-related protein Rod1 Peer-reviewed

Takahiro Shintani, Shoki Fujita, Katsuya Gomi

YEAST　32　(1)　S201-S201　2015/09

ISSN： 0749-503X

eISSN： 1097-0061
Distinct mechanism of activation of two transcription factors, AmyR and MalR, involved in amylolytic enzyme production in Aspergillus oryzae Peer-reviewed

Kuta Suzuki, Mizuki Tanaka, Yui Konno, Takanori Ichikawa, Sakurako Ichinose, Sachiko Hasegawa-Shiro, Takahiro Shintani, Katsuya Gomi

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　99　(4)　1805-1815　2015/02

DOI： 10.1007/s00253-014-6264-8 　

ISSN： 0175-7598

eISSN： 1432-0614
Evaluation of baker's yeast strains exhibiting significant growth on Japanese beet molasses and compound analysis of the molasses types Peer-reviewed

Hiroaki Nakata, Masahiko Tamura, Takahiro Shintani, Katsuya Gomi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　117　(6)　715-719　2014/06

DOI： 10.1016/j.jbiosc.2013.11.009 　

ISSN： 1389-1723

eISSN： 1347-4421
Assays for autophagy I: the cvt pathway and nonselective autophagy Peer-reviewed

Huang, W, P. Shintani, T. Xie

Methods in Molecular Biology　1163　153-164　2014/05/21

DOI： 10.1007/978-1-4939-0799-1_10 　
Improved alpha-amylase production by Aspergillus oryzae after a double deletion of genes involved in carbon catabolite repression Peer-reviewed

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　98　(1)　335-343　2014/01

DOI： 10.1007/s00253-013-5353-4 　

ISSN： 0175-7598

eISSN： 1432-0614
Fusion of an intact secretory protein permits a misfolded protein to exit from the endoplasmic reticulum in yeast Peer-reviewed

Kengo Suyama, Mizue Hori, Katsuya Gomi, Takahiro Shintani

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　78　(1)　49-59　2014/01

DOI： 10.1080/09168451.2014.877185 　

ISSN： 0916-8451

eISSN： 1347-6947
Transcripts of a heterologous gene encoding mite allergen Der f 7 are stabilized by codon optimization in Aspergillus oryzae Peer-reviewed

Mizuki Tanaka, Masafumi Tokuoka, Takahiro Shintani, Katsuya Gomi

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY　96　(5)　1275-1282　2012/12

DOI： 10.1007/s00253-012-4169-y 　

ISSN： 0175-7598
Functional analysis of FarA transcription factor in the regulation of the genes encoding lipolytic enzymes and hydrophobic surface binding protein for the degradation of biodegradable plastics in Aspergillus oryzae Peer-reviewed

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

JOURNAL OF BIOSCIENCE AND BIOENGINEERING　113　(5)　549-555　2012/05

DOI： 10.1016/j.jbiosc.2011.12.014 　

ISSN： 1389-1723
Guidelines for the use and interpretation of assays for monitoring autophagy. International-journal Peer-reviewed

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Autophagy　8　(4)　445-544　2012/04

DOI： 10.4161/auto.19496 　

eISSN： 1554-8635

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In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Identification of potential cell wall component that allows Taka-amylase A adsorption in submerged cultures of Aspergillus oryzae Peer-reviewed

Hiroki Sato, Yoshiyuki Toyoshima, Takahiro Shintani, Katsuya Gomi

Applied Microbiology and Biotechnology　92　(5)　961-969　2011/12

DOI： 10.1007/s00253-011-3422-0 　

ISSN： 0175-7598 1432-0614
In silico Analysis of 3 '-End-Processing Signals in Aspergillus oryzae Using Expressed Sequence Tags and Genomic Sequencing Data Peer-reviewed

Mizuki Tanaka, Yoshifumi Sakai, Osamu Yamada, Takahiro Shintani, Katsuya Gomi

DNA RESEARCH　18　(3)　189-200　2011/06

DOI： 10.1093/dnares/dsr011 　

ISSN： 1340-2838
Aspartyl Aminopeptidase Is Imported from the Cytoplasm to the Vacuole by Selective Autophagy in Saccharomyces cerevisiae Peer-reviewed

Masaki Yuga, Katsuya Gomi, Daniel J. Klionsky, Takahiro Shintani

JOURNAL OF BIOLOGICAL CHEMISTRY　286　(15)　13704-13713　2011/04

DOI： 10.1074/jbc.M110.173906 　

ISSN： 0021-9258
Heterologous Expression of Aspergillus oryzae Xylose Reductase and Xylitol Dehydrogenase Genes Facilitated Xylose Utilization in the Yeast Saccharomyces cerevisiae Peer-reviewed

Jitsuro Kaneda, Kenji Sasaki, Katsuya Gomi, Takahiro Shintani

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　75　(1)　168-170　2011/01

DOI： 10.1271/bbb.100639 　

ISSN： 0916-8451

eISSN： 1347-6947
Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae Peer-reviewed

Sachiko Hasegawa, Masahiro Takizawa, Haruhiko Suyama, Takahiro Shintani, Katsuya Gomi

FUNGAL GENETICS AND BIOLOGY　47　(1)　1-9　2010/01

DOI： 10.1016/j.fgb.2009.10.005 　

ISSN： 1087-1845

eISSN： 1096-0937
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy Peer-reviewed

Wei-Lien Yen, Takahiro Shintani, Usha Nair, Yang Cao, Brian C. Richardson, Zhijian Li, Frederick M. Hughson, Misuzu Baba, Daniel J. Klionsky

JOURNAL OF CELL BIOLOGY　188　(1)　101-114　2010/01

DOI： 10.1083/jcb.200904075 　

ISSN： 0021-9525
Codon Optimization Increases Steady-State mRNA Levels in Aspergillus oryzae Heterologous Gene Expression Peer-reviewed

Masafumi Tokuoka, Mizuki Tanaka, Kazuhisa Ono, Shinobu Takagi, Takahiro Shintani, Katsuya Gomi

APPLIED AND ENVIRONMENTAL MICROBIOLOGY　74　(21)　6538-6546　2008/11

DOI： 10.1128/AEM.01354-08 　

ISSN： 0099-2240

eISSN： 1098-5336
Cellular Response to the expression of an aberrant secretory protein in Aspergillus oryzae Invited Peer-reviewed

Takahiro Shintani, Daisuke Shiro, Jun-ichi Yokota, Katsuya Gomi

5th International Aspergillus Meeting　4　2008/04/04
Cellular Responses to the expression of aberrant secretory proteins in Aspergillus oryzae Invited Peer-reviewed

Takahiro Shintani, Daisuke Shiro, Jun-ichi Yokota, Katsuya Gomi

9th European Conference on Fungal Genetics　37　2008/04
FLUORESCENCE MICROSCOPY-BASED ASSAYS FOR MONITORING YEAST ATG PROTEIN TRAFFICKING Invited Peer-reviewed

Takahiro Shintani, Fulvio Reggiori

AUTOPHAGY: LOWER EUKARYOTES AND NON-MAMMALIAN SYSTEMS, PT A　451　43-56　2008

DOI： 10.1016/S0076-6879(08)03204-7 　

ISSN： 0076-6879
Atg11 directs autophagosome cargoes to the PAS along actin cables Peer-reviewed

Monastyrska, I, T Shintani, DJ Klionsky, F Reggiori

AUTOPHAGY　2　(2)　119-121　2006/04

ISSN： 1554-8627
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae Peer-reviewed

F Reggiori, L Monastyrska, T Shintani, DJ Klionsky

MOLECULAR BIOLOGY OF THE CELL　16　(12)　5843-5856　2005/12

DOI： 10.1091/mbc.E05-07-0629 　

ISSN： 1059-1524
Atg9 cycles between mitochondria and the pre-autophagosomal structure in yeasts Peer-reviewed

F Reggiori, T Shintani, U Nair, DJ Klionsky

AUTOPHAGY　1　(2)　101-109　2005/07

ISSN： 1554-8627
Atg9 and Atg23 cycle during autophagosome formation Peer-reviewed

DJ Klionsky, F Reggiori, T Shintani, KA Tucker

MOLECULAR BIOLOGY OF THE CELL　15　241A-241A　2004/11

ISSN： 1059-1524
Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway Peer-reviewed

T Shintani, DJ Klionsky

JOURNAL OF BIOLOGICAL CHEMISTRY　279　(29)　29889-29894　2004/07

DOI： 10.1074/jbc.M404399200 　

ISSN： 0021-9258
Early stages of the secretory pathway, but not endosomes, are required for cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae Peer-reviewed

F Reggiori, CW Wang, U Nair, T Shintani, H Abeliovich, DJ Klionsky

MOLECULAR BIOLOGY OF THE CELL　15　(5)　2189-2204　2004/05

DOI： 10.1091/mbc.E03-07-0479 　

ISSN： 1059-1524
Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion Peer-reviewed

F Reggiori, CW Wang, PE Stromhaug, T Shintani, DJ Klionsky

JOURNAL OF BIOLOGICAL CHEMISTRY　278　(7)　5009-5020　2003/02

DOI： 10.1074/jbc.M210436200 　

ISSN： 0021-9258
Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway Peer-reviewed

T Shintani, WP Huang, PE Stromhaug, DJ Klionsky

DEVELOPMENTAL CELL　3　(6)　825-837　2002/12

DOI： 10.1016/S1534-5807(02)00373-8 　

ISSN： 1534-5807
Apg2p functions in autophagosome formation on the perivacuolar structure Peer-reviewed

T Shintani, K Suzuki, Y Kamada, T Noda, Y Ohsumi

JOURNAL OF BIOLOGICAL CHEMISTRY　276　(32)　30452-30460　2001/08

DOI： 10.1074/jbc.M102346200 　

ISSN： 0021-9258
Tor-mediated induction of autophagy via an Apg1 protein kinase complex Peer-reviewed

Y Kamada, T Funakoshi, T Shintani, K Nagano, M Ohsumi, Y Ohsumi

JOURNAL OF CELL BIOLOGY　150　(6)　1507-1513　2000/09

DOI： 10.1083/jcb.150.6.1507 　

ISSN： 0021-9525
The Apg12 conjugation system essential for autophagy. Invited Peer-reviewed

N Mizushima, T Shintani, T Noda, T Yoshimori, M Ohsumi, Y Ohsumi

MOLECULAR BIOLOGY OF THE CELL　10　232A-232A　1999/11

ISSN： 1059-1524
Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast Peer-reviewed

T Shintani, N Mizushima, Y Ogawa, A Matsuura, T Noda, Y Ohsumi

EMBO JOURNAL　18　(19)　5234-5241　1999/10

DOI： 10.1093/emboj/18.19.5234 　

ISSN： 0261-4189
Engineering of porcine pepsin - Alteration of S-1 substrate specificity of pepsin to those of fungal aspartic proteinases by site-directed mutagenesis Peer-reviewed

T Shintani, K Nomura, E Ichishima

JOURNAL OF BIOLOGICAL CHEMISTRY　272　(30)　18855-18861　1997/07

DOI： 10.1074/jbc.272.30.18855 　

ISSN： 0021-9258
Characterization of the S 1 subsite specificity of aspergillopepsin I by site-directed mutagenesis Peer-reviewed

Takahiro Shintani, Mizue Kobayashi, Eiji Ichishima

Journal of Biochemistry　120　(5)　974-981　1996

ISSN： 0021-924X
PRIMARY STRUCTURE OF ASPERGILLOPEPSIN-I DEDUCED FROM NUCLEOTIDE-SEQUENCE OF THE GENE AND ASPARTIC ACID-76 IS AN ESSENTIAL ACTIVE-SITE OF THE ENZYME FOR TRYPSINOGEN ACTIVATION Peer-reviewed

T SHINTANI, E ICHISHIMA

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY　1204　(2)　257-264　1994/02

DOI： 10.1016/0005-2728(94)90240-2 　

ISSN： 0167-4838

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Misc. 49

The cis-element analysis of the transcription factor FlbC involved in solid-state culture-specific gene expression in Aspergillus oryzae

大沼司, 荒井啓, 小嶋慧, 藤田翔貴, 日高將文, 新谷尚弘, 五味勝也

日本農芸化学会大会講演要旨集(Web)　2022　2022

ISSN： 2186-7976
Elucidation of physiological function and substrate search of Saccharomyces cerevisiae rhomboid Pcp1p

角田俊揮, 日高將文, 小川智久, 新谷尚弘, 二井勇人

日本農芸化学会大会講演要旨集(Web)　2021　2021

ISSN： 2186-7976
出芽酵母ロンボイドPcp1pの生理機能解明と基質探索

角田俊揮, 日高將文, 小川智久, 新谷尚弘, 二井勇人

日本農芸化学会東北支部大会プログラム・講演要旨集　155th (CD-ROM)　2020
SUMO依存性ユビキチンライゲースによるヒストンバリアントH2A.Zの量的制御

高橋大輔, 日下部将之, 折原行希, 北川紗帆, 新谷尚弘, 尾間由佳子, 原田昌彦

日本分子生物学会年会プログラム・要旨集(Web)　39th　ROMBUNNO.2P‐0166 (WEB ONLY)　2016
1P-010 Effect of carbon sources on the subcellular localization and stability of carbon catabolite repression regulating factor CreA in Aspergillus oryzae

Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

67　91-91　2015
Publisher: 日本生物工学会
1P-008 The important role of an intracellular α-glucosidase, MalT, in inducible production of amylolytic enzymes in Aspergillus oryzae

Watanabe Takayasu, Ichikawa Takanori, Hasegawa-Shiro Sachiko, Tanaka Mizuki, Watanabe Akira, Shintani Takahiro, Gomi Katsuya

67　90-90　2015
Publisher: 日本生物工学会
1P-006 Mycelial morphology change during submerged culture by disruption of genes involved in carbon catabolite repression in Aspergillus oryzae

Ichinose Sakurako, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

67　90-90　2015
Publisher: 日本生物工学会
1P-007 Analyses of alternative transcription initiation event and introns within 5' untranslated region in glycolytic genes of Aspergilus oryzae

Inoue Taishi, Toji Hiroki, Takama Mitsuru, Tnaka Mizuki, Shintani Takahiro, Gomi Katsuya

67　90-90　2015
Publisher: 日本生物工学会
1P-014 Effect of overexpression of alpha-1,3-glucan synthase genes on the mycelial morphology and Taka-amylase adsorption on the cell wall in Aspergillus oryzae

Zhang Silai, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

67　92-92　2015
Publisher: 日本生物工学会
学会見聞記日本農芸化学会大会

大坪嘉行, 此木敬一, 榎本賢, 後藤知子, 新谷尚弘, 米山裕, 木村ふみ子, 高橋征司, 井上奈穂, 二井勇人

バイオサイエンスとインダストリー　72　(4)　317-326　2014/07/01
1P-030 Overexpression of heterologous genes in deletion strains of genes involved in carbon catabolite repression in Aspergillus oryzae

Ichinose Sakurako, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

66　24-24　2014
Publisher: 日本生物工学会
1P-020 An Aspergillus oryzae transcription factor involved in the expression of the gene, glaB, specifically expressed in solid-state culture

Yoshimura Midori, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

66　22-22　2014
Publisher: 日本生物工学会
1P-031 Intracellular localization of transcription factors involved in amylase production in Aspergillus oryzae

Konno Yui, Suzuki Kuta, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

66　25-25　2014
Publisher: 日本生物工学会
1P-022 Involvement of carbon sources and ubiquitinating/deubiquitinating factors in stability of Aspergillus oryzae CreA protein

Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

66　22-22　2014
Publisher: 日本生物工学会
1P-021 Morphology and enzyme production of multiple gene deletion mutants for alpha-glucan biosynthesis obtained by means of self-excising marker recycling system in Aspergillus oryzae

Zhang Silai, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

66　22-22　2014
Publisher: 日本生物工学会
2012年度日本生物工学会技術セミナー「食品加工技術と食のメタボロミクスの最前線」

新谷尚弘, 矢田恵美子

バイオサイエンスとインダストリー　71　(4)　377-379　2013/07/01
Publisher: バイオインダストリー協会
ISSN： 0914-8981
2012年度日本生物工学会技術セミナー報告

新谷尚弘

生物工学会誌　91　(5)　287-287　2013/05/25
1P-031 Involvement of arrestin-like protein CreD in regulation of glucose repression in Aspergillus oryzae

Tanaka Mizuki, Hiramoto Tetsuya, Shintani Takahiro, Gomi Katsuya

65　25-25　2013
Publisher: 日本生物工学会
1P-035 Development of a self-excising marker recycling system with a modified intron-containing Cre recombinase in Aspergillus oryzae

Zhang silai, Ban Akihiko, Ebara Naoki, Mizutani Osamu, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

65　26-26　2013
Publisher: 日本生物工学会
1P-032 Post-translational modification of transcription factors involved in amylase production in Aspergillus oryzae

Suzuki Kuta, Tanaka Mizuki, Shinitani Takahiro, Gomi Katsuya

65　25-25　2013
Publisher: 日本生物工学会
1P-034 Hyperproduction of amylases by disruption of genes involved in carbon catabolite repression in Aspergillus oryzae

Ichinose Sakurako, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

65　26-26　2013
Publisher: 日本生物工学会
出芽酵母における選択オートファジーの新規輸送基質の発見一粒で二度おいしい酵素たちの話

柚賀正樹, 新谷尚弘

化学と生物　50　(10)　771-772　2012/10

DOI： 10.1271/kagakutoseibutsu.50.708 　
Guidelines for the use and interpretation of assays for monitoring autophagy. International-journal

Daniel J Klionsky, Fabio C Abdalla, Hagai Abeliovich, Robert T Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A Aguirre-Ghiso, Hyung Jun Ahn, Ouardia Ait-Mohamed, Slimane Ait-Si-Ali, Takahiko Akematsu, Shizuo Akira, Hesham M Al-Younes, Munir A Al-Zeer, Matthew L Albert, Roger L Albin, Javier Alegre-Abarrategui, Maria Francesca Aleo, Mehrdad Alirezaei, Alexandru Almasan, Maylin Almonte-Becerril, Atsuo Amano, Ravi Amaravadi, Shoba Amarnath, Amal O Amer, Nathalie Andrieu-Abadie, Vellareddy Anantharam, David K Ann, Shailendra Anoopkumar-Dukie, Hiroshi Aoki, Nadezda Apostolova, Giuseppe Arancia, John P Aris, Katsuhiko Asanuma, Nana Y O Asare, Hisashi Ashida, Valerie Askanas, David S Askew, Patrick Auberger, Misuzu Baba, Steven K Backues, Eric H Baehrecke, Ben A Bahr, Xue-Yuan Bai, Yannick Bailly, Robert Baiocchi, Giulia Baldini, Walter Balduini, Andrea Ballabio, Bruce A Bamber, Edward T W Bampton, Gábor Bánhegyi, Clinton R Bartholomew, Diane C Bassham, Robert C Bast Jr, Henri Batoko, Boon-Huat Bay, Isabelle Beau, Daniel M Béchet, Thomas J Begley, Christian Behl, Christian Behrends, Soumeya Bekri, Bryan Bellaire, Linda J Bendall, Luca Benetti, Laura Berliocchi, Henri Bernardi, Francesca Bernassola, Sébastien Besteiro, Ingrid Bhatia-Kissova, Xiaoning Bi, Martine Biard-Piechaczyk, Janice S Blum, Lawrence H Boise, Paolo Bonaldo, David L Boone, Beat C Bornhauser, Karina R Bortoluci, Ioannis Bossis, Frédéric Bost, Jean-Pierre Bourquin, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan R Brady, Claudio Brancolini, Andreas Brech, Jay E Brenman, Ana Brennand, Emery H Bresnick, Patrick Brest, Dave Bridges, Molly L Bristol, Paul S Brookes, Eric J Brown, John H Brumell, Nicola Brunetti-Pierri, Ulf T Brunk, Dennis E Bulman, Scott J Bultman, Geert Bultynck, Lena F Burbulla, Wilfried Bursch, Jonathan P Butchar, Wanda Buzgariu, Sergio P Bydlowski, Ken Cadwell, Monika Cahová, Dongsheng Cai, Jiyang Cai, Qian Cai, Bruno Calabretta, Javier Calvo-Garrido, Nadine Camougrand, Michelangelo Campanella, Jenny Campos-Salinas, Eleonora Candi, Lizhi Cao, Allan B Caplan, Simon R Carding, Sandra M Cardoso, Jennifer S Carew, Cathleen R Carlin, Virginie Carmignac, Leticia A M Carneiro, Serena Carra, Rosario A Caruso, Giorgio Casari, Caty Casas, Roberta Castino, Eduardo Cebollero, Francesco Cecconi, Jean Celli, Hassan Chaachouay, Han-Jung Chae, Chee-Yin Chai, David C Chan, Edmond Y Chan, Raymond Chuen-Chung Chang, Chi-Ming Che, Ching-Chow Chen, Guang-Chao Chen, Guo-Qiang Chen, Min Chen, Quan Chen, Steve S-L Chen, WenLi Chen, Xi Chen, Xiangmei Chen, Xiequn Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Zhixiang Chen, Alan Cheng, Christopher H K Cheng, Yan Cheng, Heesun Cheong, Jae-Ho Cheong, Sara Cherry, Russ Chess-Williams, Zelda H Cheung, Eric Chevet, Hui-Ling Chiang, Roberto Chiarelli, Tomoki Chiba, Lih-Shen Chin, Shih-Hwa Chiou, Francis V Chisari, Chi Hin Cho, Dong-Hyung Cho, Augustine M K Choi, DooSeok Choi, Kyeong Sook Choi, Mary E Choi, Salem Chouaib, Divaker Choubey, Vinay Choubey, Charleen T Chu, Tsung-Hsien Chuang, Sheau-Huei Chueh, Taehoon Chun, Yong-Joon Chwae, Mee-Len Chye, Roberto Ciarcia, Maria R Ciriolo, Michael J Clague, Robert S B Clark, Peter G H Clarke, Robert Clarke, Patrice Codogno, Hilary A Coller, María I Colombo, Sergio Comincini, Maria Condello, Fabrizio Condorelli, Mark R Cookson, Graham H Coombs, Isabelle Coppens, Ramon Corbalan, Pascale Cossart, Paola Costelli, Safia Costes, Ana Coto-Montes, Eduardo Couve, Fraser P Coxon, James M Cregg, José L Crespo, Marianne J Cronjé, Ana Maria Cuervo, Joseph J Cullen, Mark J Czaja, Marcello D'Amelio, Arlette Darfeuille-Michaud, Lester M Davids, Faith E Davies, Massimo De Felici, John F de Groot, Cornelis A M de Haan, Luisa De Martino, Angelo De Milito, Vincenzo De Tata, Jayanta Debnath, Alexei Degterev, Benjamin Dehay, Lea M D Delbridge, Francesca Demarchi, Yi Zhen Deng, Jörn Dengjel, Paul Dent, Donna Denton, Vojo Deretic, Shyamal D Desai, Rodney J Devenish, Mario Di Gioacchino, Gilbert Di Paolo, Chiara Di Pietro, Guillermo Díaz-Araya, Inés Díaz-Laviada, Maria T Diaz-Meco, Javier Diaz-Nido, Ivan Dikic, Savithramma P Dinesh-Kumar, Wen-Xing Ding, Clark W Distelhorst, Abhinav Diwan, Mojgan Djavaheri-Mergny, Svetlana Dokudovskaya, Zheng Dong, Frank C Dorsey, Victor Dosenko, James J Dowling, Stephen Doxsey, Marlène Dreux, Mark E Drew, Qiuhong Duan, Michel A Duchosal, Karen Duff, Isabelle Dugail, Madeleine Durbeej, Michael Duszenko, Charles L Edelstein, Aimee L Edinger, Gustavo Egea, Ludwig Eichinger, N Tony Eissa, Suhendan Ekmekcioglu, Wafik S El-Deiry, Zvulun Elazar, Mohamed Elgendy, Lisa M Ellerby, Kai Er Eng, Anna-Mart Engelbrecht, Simone Engelender, Jekaterina Erenpreisa, Ricardo Escalante, Audrey Esclatine, Eeva-Liisa Eskelinen, Lucile Espert, Virginia Espina, Huizhou Fan, Jia Fan, Qi-Wen Fan, Zhen Fan, Shengyun Fang, Yongqi Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Jean-Claude Farré, Mathias Faure, Marcus Fechheimer, Carl G Feng, Jian Feng, Qili Feng, Youji Feng, László Fésüs, Ralph Feuer, Maria E Figueiredo-Pereira, Gian Maria Fimia, Diane C Fingar, Steven Finkbeiner, Toren Finkel, Kim D Finley, Filomena Fiorito, Edward A Fisher, Paul B Fisher, Marc Flajolet, Maria L Florez-McClure, Salvatore Florio, Edward A Fon, Francesco Fornai, Franco Fortunato, Rati Fotedar, Daniel H Fowler, Howard S Fox, Rodrigo Franco, Lisa B Frankel, Marc Fransen, José M Fuentes, Juan Fueyo, Jun Fujii, Kozo Fujisaki, Eriko Fujita, Mitsunori Fukuda, Ruth H Furukawa, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Brigitte Galliot, Vincent Galy, Subramaniam Ganesh, Barry Ganetzky, Ian G Ganley, Fen-Biao Gao, George F Gao, Jinming Gao, Lorena Garcia, Guillermo Garcia-Manero, Mikel Garcia-Marcos, Marjan Garmyn, Andrei L Gartel, Evelina Gatti, Mathias Gautel, Thomas R Gawriluk, Matthew E Gegg, Jiefei Geng, Marc Germain, Jason E Gestwicki, David A Gewirtz, Saeid Ghavami, Pradipta Ghosh, Anna M Giammarioli, Alexandra N Giatromanolaki, Spencer B Gibson, Robert W Gilkerson, Michael L Ginger, Henry N Ginsberg, Jakub Golab, Michael S Goligorsky, Pierre Golstein, Candelaria Gomez-Manzano, Ebru Goncu, Céline Gongora, Claudio D Gonzalez, Ramon Gonzalez, Cristina González-Estévez, Rosa Ana González-Polo, Elena Gonzalez-Rey, Nikolai V Gorbunov, Sharon Gorski, Sandro Goruppi, Roberta A Gottlieb, Devrim Gozuacik, Giovanna Elvira Granato, Gary D Grant, Kim N Green, Aleš Gregorc, Frédéric Gros, Charles Grose, Thomas W Grunt, Philippe Gual, Jun-Lin Guan, Kun-Liang Guan, Sylvie M Guichard, Anna S Gukovskaya, Ilya Gukovsky, Jan Gunst, Asa B Gustafsson, Andrew J Halayko, Amber N Hale, Sandra K Halonen, Maho Hamasaki, Feng Han, Ting Han, Michael K Hancock, Malene Hansen, Hisashi Harada, Masaru Harada, Stefan E Hardt, J Wade Harper, Adrian L Harris, James Harris, Steven D Harris, Makoto Hashimoto, Jeffrey A Haspel, Shin-ichiro Hayashi, Lori A Hazelhurst, Congcong He, You-Wen He, Marie-Joseé Hébert, Kim A Heidenreich, Miep H Helfrich, Gudmundur V Helgason, Elizabeth P Henske, Brian Herman, Paul K Herman, Claudio Hetz, Sabine Hilfiker, Joseph A Hill, Lynne J Hocking, Paul Hofman, Thomas G Hofmann, Jörg Höhfeld, Tessa L Holyoake, Ming-Huang Hong, David A Hood, Gökhan S Hotamisligil, Ewout J Houwerzijl, Maria Høyer-Hansen, Bingren Hu, Chien-An A Hu, Hong-Ming Hu, Ya Hua, Canhua Huang, Ju Huang, Shengbing Huang, Wei-Pang Huang, Tobias B Huber, Won-Ki Huh, Tai-Ho Hung, Ted R Hupp, Gang Min Hur, James B Hurley, Sabah N A Hussain, Patrick J Hussey, Jung Jin Hwang, Seungmin Hwang, Atsuhiro Ichihara, Shirin Ilkhanizadeh, Ken Inoki, Takeshi Into, Valentina Iovane, Juan L Iovanna, Nancy Y Ip, Yoshitaka Isaka, Hiroyuki Ishida, Ciro Isidoro, Ken-ichi Isobe, Akiko Iwasaki, Marta Izquierdo, Yotaro Izumi, Panu M Jaakkola, Marja Jäättelä, George R Jackson, William T Jackson, Bassam Janji, Marina Jendrach, Ju-Hong Jeon, Eui-Bae Jeung, Hong Jiang, Hongchi Jiang, Jean X Jiang, Ming Jiang, Qing Jiang, Xuejun Jiang, Xuejun Jiang, Alberto Jiménez, Meiyan Jin, Shengkan Jin, Cheol O Joe, Terje Johansen, Daniel E Johnson, Gail V W Johnson, Nicola L Jones, Bertrand Joseph, Suresh K Joseph, Annie M Joubert, Gábor Juhász, Lucienne Juillerat-Jeanneret, Chang Hwa Jung, Yong-Keun Jung, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Motoni Kadowaki, Katarina Kagedal, Yoshiaki Kamada, Vitaliy O Kaminskyy, Harm H Kampinga, Hiromitsu Kanamori, Chanhee Kang, Khong Bee Kang, Kwang Il Kang, Rui Kang, Yoon-A Kang, Tomotake Kanki, Thirumala-Devi Kanneganti, Haruo Kanno, Anumantha G Kanthasamy, Arthi Kanthasamy, Vassiliki Karantza, Gur P Kaushal, Susmita Kaushik, Yoshinori Kawazoe, Po-Yuan Ke, John H Kehrl, Ameeta Kelekar, Claus Kerkhoff, David H Kessel, Hany Khalil, Jan A K W Kiel, Amy A Kiger, Akio Kihara, Deok Ryong Kim, Do-Hyung Kim, Dong-Hou Kim, Eun-Kyoung Kim, Hyung-Ryong Kim, Jae-Sung Kim, Jeong Hun Kim, Jin Cheon Kim, John K Kim, Peter K Kim, Seong Who Kim, Yong-Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C Kimmelman, Jason S King, Timothy J Kinsella, Vladimir Kirkin, Lorrie A Kirshenbaum, Katsuhiko Kitamoto, Kaio Kitazato, Ludger Klein, Walter T Klimecki, Jochen Klucken, Erwin Knecht, Ben C B Ko, Jan C Koch, Hiroshi Koga, Jae-Young Koh, Young Ho Koh, Masato Koike, Masaaki Komatsu, Eiki Kominami, Hee Jeong Kong, Wei-Jia Kong, Viktor I Korolchuk, Yaichiro Kotake, Michael I Koukourakis, Juan B Kouri Flores, Attila L Kovács, Claudine Kraft, Dimitri Krainc, Helmut Krämer, Carole Kretz-Remy, Anna M Krichevsky, Guido Kroemer, Rejko Krüger, Oleg Krut, Nicholas T Ktistakis, Chia-Yi Kuan, Roza Kucharczyk, Ashok Kumar, Raj Kumar, Sharad Kumar, Mondira Kundu, Hsing-Jien Kung, Tino Kurz, Ho Jeong Kwon, Albert R La Spada, Frank Lafont, Trond Lamark, Jacques Landry, Jon D Lane, Pierre Lapaquette, Jocelyn F Laporte, Lajos László, Sergio Lavandero, Josée N Lavoie, Robert Layfield, Pedro A Lazo, Weidong Le, Laurent Le Cam, Daniel J Ledbetter, Alvin J X Lee, Byung-Wan Lee, Gyun Min Lee, Jongdae Lee, Ju-Hyun Lee, Michael Lee, Myung-Shik Lee, Sug Hyung Lee, Christiaan Leeuwenburgh, Patrick Legembre, Renaud Legouis, Michael Lehmann, Huan-Yao Lei, Qun-Ying Lei, David A Leib, José Leiro, John J Lemasters, Antoinette Lemoine, Maciej S Lesniak, Dina Lev, Victor V Levenson, Beth Levine, Efrat Levy, Faqiang Li, Jun-Lin Li, Lian Li, Sheng Li, Weijie Li, Xue-Jun Li, Yan-bo Li, Yi-Ping Li, Chengyu Liang, Qiangrong Liang, Yung-Feng Liao, Pawel P Liberski, Andrew Lieberman, Hyunjung J Lim, Kah-Leong Lim, Kyu Lim, Chiou-Feng Lin, Fu-Cheng Lin, Jian Lin, Jiandie D Lin, Kui Lin, Wan-Wan Lin, Weei-Chin Lin, Yi-Ling Lin, Rafael Linden, Paul Lingor, Jennifer Lippincott-Schwartz, Michael P Lisanti, Paloma B Liton, Bo Liu, Chun-Feng Liu, Kaiyu Liu, Leyuan Liu, Qiong A Liu, Wei Liu, Young-Chau Liu, Yule Liu, Richard A Lockshin, Chun-Nam Lok, Sagar Lonial, Benjamin Loos, Gabriel Lopez-Berestein, Carlos López-Otín, Laura Lossi, Michael T Lotze, Peter Lőw, Binfeng Lu, Bingwei Lu, Bo Lu, Zhen Lu, Frédéric Luciano, Nicholas W Lukacs, Anders H Lund, Melinda A Lynch-Day, Yong Ma, Fernando Macian, Jeff P MacKeigan, Kay F Macleod, Frank Madeo, Luigi Maiuri, Maria Chiara Maiuri, Davide Malagoli, May Christine V Malicdan, Walter Malorni, Na Man, Eva-Maria Mandelkow, Stéphen Manon, Irena Manov, Kai Mao, Xiang Mao, Zixu Mao, Philippe Marambaud, Daniela Marazziti, Yves L Marcel, Katie Marchbank, Piero Marchetti, Stefan J Marciniak, Mateus Marcondes, Mohsen Mardi, Gabriella Marfe, Guillermo Mariño, Maria Markaki, Mark R Marten, Seamus J Martin, Camille Martinand-Mari, Wim Martinet, Marta Martinez-Vicente, Matilde Masini, Paola Matarrese, Saburo Matsuo, Raffaele Matteoni, Andreas Mayer, Nathalie M Mazure, David J McConkey, Melanie J McConnell, Catherine McDermott, Christine McDonald, Gerald M McInerney, Sharon L McKenna, BethAnn McLaughlin, Pamela J McLean, Christopher R McMaster, G Angus McQuibban, Alfred J Meijer, Miriam H Meisler, Alicia Meléndez, Thomas J Melia, Gerry Melino, Maria A Mena, Javier A Menendez, Rubem F S Menna-Barreto, Manoj B Menon, Fiona M Menzies, Carol A Mercer, Adalberto Merighi, Diane E Merry, Stefania Meschini, Christian G Meyer, Thomas F Meyer, Chao-Yu Miao, Jun-Ying Miao, Paul A M Michels, Carine Michiels, Dalibor Mijaljica, Ana Milojkovic, Saverio Minucci, Clelia Miracco, Cindy K Miranti, Ioannis Mitroulis, Keisuke Miyazawa, Noboru Mizushima, Baharia Mograbi, Simin Mohseni, Xavier Molero, Bertrand Mollereau, Faustino Mollinedo, Takashi Momoi, Iryna Monastyrska, Martha M Monick, Mervyn J Monteiro, Michael N Moore, Rodrigo Mora, Kevin Moreau, Paula I Moreira, Yuji Moriyasu, Jorge Moscat, Serge Mostowy, Jeremy C Mottram, Tomasz Motyl, Charbel E-H Moussa, Sylke Müller, Sylviane Muller, Karl Münger, Christian Münz, Leon O Murphy, Maureen E Murphy, Antonio Musarò, Indira Mysorekar, Eiichiro Nagata, Kazuhiro Nagata, Aimable Nahimana, Usha Nair, Toshiyuki Nakagawa, Kiichi Nakahira, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Naweed I Naqvi, Derek P Narendra, Masashi Narita, Miguel Navarro, Steffan T Nawrocki, Taras Y Nazarko, Andriy Nemchenko, Mihai G Netea, Thomas P Neufeld, Paul A Ney, Ioannis P Nezis, Huu Phuc Nguyen, Daotai Nie, Ichizo Nishino, Corey Nislow, Ralph A Nixon, Takeshi Noda, Angelika A Noegel, Anna Nogalska, Satoru Noguchi, Lucia Notterpek, Ivana Novak, Tomoyoshi Nozaki, Nobuyuki Nukina, Thorsten Nürnberger, Beat Nyfeler, Keisuke Obara, Terry D Oberley, Salvatore Oddo, Michinaga Ogawa, Toya Ohashi, Koji Okamoto, Nancy L Oleinick, F Javier Oliver, Laura J Olsen, Stefan Olsson, Onya Opota, Timothy F Osborne, Gary K Ostrander, Kinya Otsu, Jing-hsiung James Ou, Mireille Ouimet, Michael Overholtzer, Bulent Ozpolat, Paolo Paganetti, Ugo Pagnini, Nicolas Pallet, Glen E Palmer, Camilla Palumbo, Tianhong Pan, Theocharis Panaretakis, Udai Bhan Pandey, Zuzana Papackova, Issidora Papassideri, Irmgard Paris, Junsoo Park, Ohkmae K Park, Jan B Parys, Katherine R Parzych, Susann Patschan, Cam Patterson, Sophie Pattingre, John M Pawelek, Jianxin Peng, David H Perlmutter, Ida Perrotta, George Perry, Shazib Pervaiz, Matthias Peter, Godefridus J Peters, Morten Petersen, Goran Petrovski, James M Phang, Mauro Piacentini, Philippe Pierre, Valérie Pierrefite-Carle, Gérard Pierron, Ronit Pinkas-Kramarski, Antonio Piras, Natik Piri, Leonidas C Platanias, Stefanie Pöggeler, Marc Poirot, Angelo Poletti, Christian Poüs, Mercedes Pozuelo-Rubio, Mette Prætorius-Ibba, Anil Prasad, Mark Prescott, Muriel Priault, Nathalie Produit-Zengaffinen, Ann Progulske-Fox, Tassula Proikas-Cezanne, Serge Przedborski, Karin Przyklenk, Rosa Puertollano, Julien Puyal, Shu-Bing Qian, Liang Qin, Zheng-Hong Qin, Susan E Quaggin, Nina Raben, Hannah Rabinowich, Simon W Rabkin, Irfan Rahman, Abdelhaq Rami, Georg Ramm, Glenn Randall, Felix Randow, V Ashutosh Rao, Jeffrey C Rathmell, Brinda Ravikumar, Swapan K Ray, Bruce H Reed, John C Reed, Fulvio Reggiori, Anne Régnier-Vigouroux, Andreas S Reichert, John J Reiners Jr, Russel J Reiter, Jun Ren, José L Revuelta, Christopher J Rhodes, Konstantinos Ritis, Elizete Rizzo, Jeffrey Robbins, Michel Roberge, Hernan Roca, Maria C Roccheri, Stephane Rocchi, H Peter Rodemann, Santiago Rodríguez de Córdoba, Bärbel Rohrer, Igor B Roninson, Kirill Rosen, Magdalena M Rost-Roszkowska, Mustapha Rouis, Kasper M A Rouschop, Francesca Rovetta, Brian P Rubin, David C Rubinsztein, Klaus Ruckdeschel, Edmund B Rucker 3rd, Assaf Rudich, Emil Rudolf, Nelson Ruiz-Opazo, Rossella Russo, Tor Erik Rusten, Kevin M Ryan, Stefan W Ryter, David M Sabatini, Junichi Sadoshima, Tapas Saha, Tatsuya Saitoh, Hiroshi Sakagami, Yasuyoshi Sakai, Ghasem Hoseini Salekdeh, Paolo Salomoni, Paul M Salvaterra, Guy Salvesen, Rosa Salvioli, Anthony M J Sanchez, José A Sánchez-Alcázar, Ricardo Sánchez-Prieto, Marco Sandri, Uma Sankar, Poonam Sansanwal, Laura Santambrogio, Shweta Saran, Sovan Sarkar, Minnie Sarwal, Chihiro Sasakawa, Ausra Sasnauskiene, Miklós Sass, Ken Sato, Miyuki Sato, Anthony H V Schapira, Michael Scharl, Hermann M Schätzl, Wiep Scheper, Stefano Schiaffino, Claudio Schneider, Marion E Schneider, Regine Schneider-Stock, Patricia V Schoenlein, Daniel F Schorderet, Christoph Schüller, Gary K Schwartz, Luca Scorrano, Linda Sealy, Per O Seglen, Juan Segura-Aguilar, Iban Seiliez, Oleksandr Seleverstov, Christian Sell, Jong Bok Seo, Duska Separovic, Vijayasaradhi Setaluri, Takao Setoguchi, Carmine Settembre, John J Shacka, Mala Shanmugam, Irving M Shapiro, Eitan Shaulian, Reuben J Shaw, James H Shelhamer, Han-Ming Shen, Wei-Chiang Shen, Zu-Hang Sheng, Yang Shi, Kenichi Shibuya, Yoshihiro Shidoji, Jeng-Jer Shieh, Chwen-Ming Shih, Yohta Shimada, Shigeomi Shimizu, Takahiro Shintani, Orian S Shirihai, Gordon C Shore, Andriy A Sibirny, Stan B Sidhu, Beata Sikorska, Elaine C M Silva-Zacarin, Alison Simmons, Anna Katharina Simon, Hans-Uwe Simon, Cristiano Simone, Anne Simonsen, David A Sinclair, Rajat Singh, Debasish Sinha, Frank A Sinicrope, Agnieszka Sirko, Parco M Siu, Efthimios Sivridis, Vojtech Skop, Vladimir P Skulachev, Ruth S Slack, Soraya S Smaili, Duncan R Smith, Maria S Soengas, Thierry Soldati, Xueqin Song, Anil K Sood, Tuck Wah Soong, Federica Sotgia, Stephen A Spector, Claudia D Spies, Wolfdieter Springer, Srinivasa M Srinivasula, Leonidas Stefanis, Joan S Steffan, Ruediger Stendel, Harald Stenmark, Anastasis Stephanou, Stephan T Stern, Cinthya Sternberg, Björn Stork, Peter Strålfors, Carlos S Subauste, Xinbing Sui, David Sulzer, Jiaren Sun, Shi-Yong Sun, Zhi-Jun Sun, Joseph J Y Sung, Kuninori Suzuki, Toshihiko Suzuki, Michele S Swanson, Charles Swanton, Sean T Sweeney, Lai-King Sy, Gyorgy Szabadkai, Ira Tabas, Heinrich Taegtmeyer, Marco Tafani, Krisztina Takács-Vellai, Yoshitaka Takano, Kaoru Takegawa, Genzou Takemura, Fumihiko Takeshita, Nicholas J Talbot, Kevin S W Tan, Keiji Tanaka, Kozo Tanaka, Daolin Tang, Dingzhong Tang, Isei Tanida, Bakhos A Tannous, Nektarios Tavernarakis, Graham S Taylor, Gregory A Taylor, J Paul Taylor, Lance S Terada, Alexei Terman, Gianluca Tettamanti, Karin Thevissen, Craig B Thompson, Andrew Thorburn, Michael Thumm, FengFeng Tian, Yuan Tian, Glauco Tocchini-Valentini, Aviva M Tolkovsky, Yasuhiko Tomino, Lars Tönges, Sharon A Tooze, Cathy Tournier, John Tower, Roberto Towns, Vladimir Trajkovic, Leonardo H Travassos, Ting-Fen Tsai, Mario P Tschan, Takeshi Tsubata, Allan Tsung, Boris Turk, Lorianne S Turner, Suresh C Tyagi, Yasuo Uchiyama, Takashi Ueno, Midori Umekawa, Rika Umemiya-Shirafuji, Vivek K Unni, Maria I Vaccaro, Enza Maria Valente, Greet Van den Berghe, Ida J van der Klei, Wouter van Doorn, Linda F van Dyk, Marjolein van Egmond, Leo A van Grunsven, Peter Vandenabeele, Wim P Vandenberghe, Ilse Vanhorebeek, Eva C Vaquero, Guillermo Velasco, Tibor Vellai, Jose Miguel Vicencio, Richard D Vierstra, Miquel Vila, Cécile Vindis, Giampietro Viola, Maria Teresa Viscomi, Olga V Voitsekhovskaja, Clarissa von Haefen, Marcela Votruba, Keiji Wada, Richard Wade-Martins, Cheryl L Walker, Craig M Walsh, Jochen Walter, Xiang-Bo Wan, Aimin Wang, Chenguang Wang, Dawei Wang, Fan Wang, Fen Wang, Guanghui Wang, Haichao Wang, Hong-Gang Wang, Horng-Dar Wang, Jin Wang, Ke Wang, Mei Wang, Richard C Wang, Xinglong Wang, Xuejun Wang, Ying-Jan Wang, Yipeng Wang, Zhen Wang, Zhigang Charles Wang, Zhinong Wang, Derick G Wansink, Diane M Ward, Hirotaka Watada, Sarah L Waters, Paul Webster, Lixin Wei, Conrad C Weihl, William A Weiss, Scott M Welford, Long-Ping Wen, Caroline A Whitehouse, J Lindsay Whitton, Alexander J Whitworth, Tom Wileman, John W Wiley, Simon Wilkinson, Dieter Willbold, Roger L Williams, Peter R Williamson, Bradly G Wouters, Chenghan Wu, Dao-Cheng Wu, William K K Wu, Andreas Wyttenbach, Ramnik J Xavier, Zhijun Xi, Pu Xia, Gengfu Xiao, Zhiping Xie, Zhonglin Xie, Da-zhi Xu, Jianzhen Xu, Liang Xu, Xiaolei Xu, Ai Yamamoto, Akitsugu Yamamoto, Shunhei Yamashina, Michiaki Yamashita, Xianghua Yan, Mitsuhiro Yanagida, Dun-Sheng Yang, Elizabeth Yang, Jin-Ming Yang, Shi Yu Yang, Wannian Yang, Wei Yuan Yang, Zhifen Yang, Meng-Chao Yao, Tso-Pang Yao, Behzad Yeganeh, Wei-Lien Yen, Jia-jing Yin, Xiao-Ming Yin, Ook-Joon Yoo, Gyesoon Yoon, Seung-Yong Yoon, Tomohiro Yorimitsu, Yuko Yoshikawa, Tamotsu Yoshimori, Kohki Yoshimoto, Ho Jin You, Richard J Youle, Anas Younes, Li Yu, Long Yu, Seong-Woon Yu, Wai Haung Yu, Zhi-Min Yuan, Zhenyu Yue, Cheol-Heui Yun, Michisuke Yuzaki, Olga Zabirnyk, Elaine Silva-Zacarin, David Zacks, Eldad Zacksenhaus, Nadia Zaffaroni, Zahra Zakeri, Herbert J Zeh 3rd, Scott O Zeitlin, Hong Zhang, Hui-Ling Zhang, Jianhua Zhang, Jing-Pu Zhang, Lin Zhang, Long Zhang, Ming-Yong Zhang, Xu Dong Zhang, Mantong Zhao, Yi-Fang Zhao, Ying Zhao, Zhizhuang J Zhao, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Cong-Zhao Zhou, Changlian Zhu, Wei-Guo Zhu, Xiao-Feng Zhu, Xiongwei Zhu, Yuangang Zhu, Teresa Zoladek, Wei-Xing Zong, Antonio Zorzano, Jürgen Zschocke, Brian Zuckerbraun

Autophagy　8　(4)　445-544　2012/04

DOI： 10.4161/auto.19496 　

eISSN： 1554-8635

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In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
3Da11 Depression of carbon catabolite repression by disruption of ubiquitin C-terminal hydrolase, CreB, in Aspergillus oryzae

Tanaka Mizuki, Shintani Takahiro, Gomi katsuya

64　131-131　2012
Publisher: 日本生物工学会
3Fa04 Effect of carbon source species on the endocytosis of Aspergillus maltose permease

Hiramoto Tetsuya, Daidoguchi Ryoko, Tanaka Mizuki, Shintani Takahiro, Gomi Katsuya

63　230-230　2011
Publisher: 日本生物工学会
農芸化学会大会

七谷圭, 新谷尚弘, 後藤知子, 白川仁, 都築毅, 榎本賢, 此木敬一, 小関卓也, 日出間志寿, 稲葉靖子, 宮内啓介, 矢部富雄

バイオサイエンスとインダストリー = Bioscience & industry　68　(4)　259-268　2010/07/01
Publisher: バイオインダストリー協会
ISSN： 0914-8981
日本農芸化学会大会学会見聞録

七谷圭, 新谷尚弘, 後藤知子, 白川仁, 都築毅, 榎本賢, 此木敬一, 小関卓也, 日出間志寿, 稲葉靖子, 宮内啓介, 矢部富雄

バイオサイエンスとインダストリー　68　(4)　263-264　2010/07
Publisher: 一般財団法人バイオインダストリー協会
学会見聞記 2010年度日本農芸化学会大会

七谷圭, 新谷尚弘, 後藤知子, 白川仁, 都築毅, 榎本賢, 此木敬一, 小関卓也, 日出間志寿, 稲葉靖子, 宮内啓介, 矢部富雄

バイオサイエンスとインダストリー　68　(4)　259-268　2010/07/01
Characterization and expression analysis of a maltose-utilizing (MAL) cluster in Aspergillus oryzae (vol 47, pg 1, 2010)

Sachiko Hasegawa, Masahiro Takizawa, Haruhiko Suyama, Takahiro Shintani, Katsuya Gomi

FUNGAL GENETICS AND BIOLOGY　47　(5)　497-497　2010/05

DOI： 10.1016/j.fgb.2009.12.002 　

ISSN： 1087-1845
3P-1101 Adsorption of Taka-amylase onto cell wall by disruption of an alpha-1,3-glucan synthase gene in Aspergillus oryzae

SATO Hiroki, SHINTANI Takahiro, GOMI Katsuya

22　83-83　2010
Publisher: 日本生物工学会
Current Topics in Molecular Biotechnology of a Koji Mold, Aspergillus oryzae(Recent Topics of the Agricultunal Biological Science in Tohoku University)

Katsuya GOMI, Takahiro SHINTANI, Laboratory of Bioindustrial Genomics Graduate School of Agricultural Science Tohoku University, Laboratory of Bioindustrial Genomics Graduate School of Agricultural Science Tohoku University

Tohoku journal of agricultural research　58　(3)　175-181　2008/03/01

ISSN： 0040-8719
3S1a04 Recent advances in heterologous protein production in Aspergillus oryzae

GOMI Katsuya, SHINTANI Takahiro

20　12-12　2008
Publisher: 日本生物工学会
2Gp12 Purification and characterization of novel endo-β-1,4-glucanase from Aspergillus oryzae.

Ujiie Seiryu, Ohashi Masataka, Watanabe Akira, Shintani Takahiro, Gomi Katsuya

20　182-182　2008
Publisher: 日本生物工学会
2Dp07 Construction of yeast expression libraries for cellulolytic enzyme genes from A. oryzae

OHASHI Masataka, GOMI Katsuya, SHINTANI Takahiro

20　123-123　2008
Publisher: 日本生物工学会
2Da05 Production of proteases and recombinant protein in prtR disruptants of Aspergillus oryzae

ONOZAKI Yasumichi, MATSUURA Tomomi, SHINTANI Takahiro, GOMI Katsuya

20　119-119　2008
Publisher: 日本生物工学会
学会見聞記 2007年度日本農芸学会大会(1)

清田洋正, 中嶋正敏, 金子淳, 新谷尚弘, 山形洋平, 山下まり

バイオサイエンスとインダストリー / バイオサイエンスとインダストリー編集委員会編　65　(6)　300-304　2007/06
Publisher: バイオインダストリー協会
ISSN： 0914-8981

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記事種別: 特集 ; 会議・学会報告・シンポジウム
学会見聞記 2007年度日本農芸化学会大会

清田洋正, 中嶋正敏, 金子淳, 新谷尚弘, 山形洋平, 山下まり

Bioscience & Industry　65　(6)　34-38　2007/06/01
Publisher: バイオインダストリー協会
Cytoplasm to vacuole targeting pathway in yeast.

Takahiro Shintani

Tanpakusitsu Kakusan Koso　51　(10)　1480-1483　2006/08/10
Publisher: Kyoritsu Shuppan
出芽酵母のオートファジーに必須な遺伝子群酵母Cvt経路 (ユビキチン-プロテアソーム系とオートファジー--作動機構と病態生理) -- (オートファジー-リソソーム/液胞系)

新谷尚弘

蛋白質核酸酵素　51　(10)　1480-1483　2006/08
Publisher: 共立出版
ISSN： 0039-9450
Recycle and disposal in the cell.

Takahiro Shintani

Seibutsu-kougaku Kaishi　84　(7)　289-289　2006/07/25
Publisher: The Society for Biotechnology, Japan
ISSN： 0919-3758
1H12-2 Cellular response to the expression of the unfolded secretory protein in Aspergillus oryzae

YOKOTA Junichi, SHIRO Daisuke, TATARA Yota, ICHISHIMA Eiji, SHINTANI Takahiro, GOMI Katuya

18　132-132　2006
Publisher: 日本生物工学会
1H14-1 Improvement of heterologous protein production in Aspergillus oryzae strain with decreased protease activity

MATSUURA Tomomi, SHIRO Daisuke, TOKUOKA Masafumi, SHINTANI Takahiro, GOMI Katsuya

18　132-132　2006
Publisher: 日本生物工学会
Autophagy in health and disease: A double-edged sword

T Shintani, DJ Klionsky

SCIENCE　306　(5698)　990-995　2004/11

DOI： 10.1126/science.1099993 　

ISSN： 0036-8075
Autophagy and Apg12 conjugation system

Noboru Mizushima, Takahiro Shintani, Yoshinori Ohsumi

Cell Technology　19　(2)　286-294　2000/02
Publisher: Shujunsha
ISSN： 0287-3796
A novel protein conjugation system essential for autophagy

MIZUSHIMA Noboru, SUGITA Hisao, SHINTANI Takahiro, NODA Takeshi, YOSHIMORI Tamotsu, OHSUMI Mariko, OHSUMI Yoshinori

21　459-459　1998/12/01
蛋白質工学的手法によるブタ・ペプシンの基質特異性の変換

新谷尚弘, 野村耕司, 一島英治

日本分子生物学会年会プログラム・講演要旨集　19　716-716　1996/08/01
アスペルギロペプシンIのSer-78の役割 : タンパク質工学

新谷尚弘, 一島英治

日本農藝化學會誌　69　88-88　1995/07/05
Publisher: 社団法人日本農芸化学会
ISSN： 0002-1407
Aspergillopepsin 1のAsp-76変異酵素の酵素化学 : タンパク質工学

小林瑞枝, 新谷尚弘, 一島英治

日本農藝化學會誌　69　88-88　1995/07/05
Publisher: 社団法人日本農芸化学会
ISSN： 0002-1407
アスペルギロペプシンIのAsp-30の分子機能 : タンパク質工学

新谷尚弘, 藤田晃子, 一島英治

日本農藝化學會誌　69　87-87　1995/07/05
Publisher: 社団法人日本農芸化学会
ISSN： 0002-1407

Show all ︎Show first 5

Books and Other Publications 2

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Takahiro Shintani

Academic Press　2016

ISBN: 9780128029367
酵素ハンドブック

新谷尚弘ほか

朝倉書店　2008/05/30

ISBN: 9784254171136

Presentations 300

麹菌における異種タンパク質の高生産を目指した小胞体ストレスセンサーIreA の機能解析

横山将己, 五味勝也, 新谷尚弘

日本農芸化学会東北支部第159 回大会　2024/09/28
出芽酵母における輸送体のグルコース不活性化機構の解析

中聖亜, 藤田翔貴, 五味勝也, 新谷尚弘

日本農芸化学会東北支部第159 回大会　2024/09/28
Saccharomyces cerevisiaeにおける偏ったアミノ酸摂取による細胞毒性

三浦佑太, 伊勢大輝, 菊池万由子, 五味勝也, 新谷尚弘

酵母遺伝学フォーラム第57回研究報告会　2024/09/09
出芽酵母におけるα-アレスチンタンパク質Rod1による輸送体分解制御機構の解析

中聖亜, 藤田翔貴, 五味勝也, 新谷尚弘

酵母遺伝学フォーラム第57回研究報告会　2024/09/09
Response to the production of foreign proteins in Aspergilli

2024/03/27
Establishment of a method for introducing multiple copies of genes into the genome with CRISPR/Cas9 in Aspergillus oryzae

2024/03/25
Mannanase activity newly found in endoglucanases from Aspergillus oryzae obtained by genome mining

2024/03/25
A novel isomaltose sensor/transporter identification involved in the activation of the transcription factor AmyR in Aspergillus oryzae and A. nidulans.

Da Min Jeong, Jikian Tokashiki, Tomoko Shintani, Takahiro Shintani, Katsuya Gomi

32nd Fungal Genetics Conference (March 12-17, 2024 Asilomar, California)
Localization and functional domain analysis of AmyR in the black koji mold Aspergillus luchuensis and its closely related species.

Jikian Tokashiki, Taichi Morise, Wataru Hashimoto, Shoki Fujita, Takashiro Shintani, Katsuya Gomi

32nd Fungal Genetics Conference (Asilomar, California)
A novel isomaltose sensor/transporter identification involved in the activation of the transcription factor AmyR in Aspergillus oryzae and A. nidulans.

Da Min Jeong, Jikian Tokashiki, Tomoko Shintani, Takahiro Shintani, Katsuya Gomi

The 20th International Aspergillus Meeting Asperfest 20 (Asilomar, California)　2024/03/11
Localization and functional domain analysis of AmyR in the black koji mold Aspergillus luchuensis and its closely related species.

Jikian Tokashiki, Taichi Morise, Wataru Hashimoto, Shoki Fujita, Takashiro Shintani, Katsuya Gomi

The 20th International Aspergillus Meeting Asperfest 20 (Asilomar, California)　2024/03
固体培養特異的に発現する麹菌glaB遺伝子プロモーターの AmyRのシスエレメント

青西洋平, 大沼司, 渡部昭, 新谷尚弘, 五味勝也

第22回糸状菌分子生物学コンファレンス　2023/11/22
転写因子AmyRの活性化に関わるコウジカビの新規イソマルトースセンサー遺伝子の同定 Invited

ジョンダミン, 渡嘉敷直杏, 新谷智子, 新谷尚弘, 五味勝也

第22回糸状菌分子生物学コンファレンス　2023/11/22
Identification of an isomaltose sensor involved in amylolytic enzyme production in Aspergillus

Da Min Jeong, Jikian Tokashiki, Takahiro Shintani, Katsuya Gomi

第75回日本生物工学会大会　2023/09/04
麴菌の固体培養特異的発現を示すグルコアミラーゼ遺伝子glaBプロモーターに存在するAmyRのシスエレメントの同定

青西洋平, 大沼司, 渡部昭, 新谷尚弘, 五味勝也

第75回日本生物工学会大会　2023/09/04
出芽酵母におけるR-SNAREの機能重複に対する遺伝学的洞察

渡部颯, 浦野真吾, 菊地のぞみ, 久保優里花, 菊地あゆみ, 五味勝也, 新谷尚弘

酵母遺伝学フォーラム第56回研究報告会　2023/08/30
醤油麹菌Aspergillus sojaeにおける転写因子AsFlbCおよびAsPrtRの固体培養特異的な酵素生産への影響

藤田翔貴, 新谷尚弘, 五味勝也

日本農芸化学会2023年度（令和5年度）大会　2023/03/15
出芽酵母の液胞同型融合におけるYkt6とNyv1の機能重複に対する遺伝学的洞察

渡部颯, 久保優里花, 浦野真吾, 五味勝也, 新谷尚弘

日本農芸化学会2023年度（令和5年度）大会　2023/03/15
出芽酵母のアミノ酸ストレスに対する応答

三浦佑太, 安藝萌, 五味勝也, 新谷尚弘

日本農芸化学会2023年度（令和5年度）大会　2023/03/15
Distinct amylase gene expression profiles in the black koji-mold Aspergillus luchuensis and its closely related species

Morise T, Hashimoto W, Tokashiki J, Fujita S, Shintani T, Gomi K

The 16th European Conference on Fungal Genetics　2023/03/06
DNA-binding sequences of the transcription factor FlbC involved in the regulation of Aspergillus oryzae genes specifically expressed in solid-state culture

Ohnuma T, Arai H, Kojima K, Hidaka M, Shintani T, Gomi K

The 16th European Conference on Fungal Genetics　2023/03/06
Effect of the transcription factor AsFlbC deletion on enzyme production in solid state culture in Aspergillus sojae

Fujita S, Katayama T, Maruyama J, Shintani T, Gomi K

The 16th European Conference on Fungal Genetics　2023/03/06
Distinct amylase gene expression profiles in the black koji-mold Aspergillus luchuensis and its closely related species.

Morise T, Hashimoto W, Tokashiki J, Fujita S, Shintani T, Gomi K

The 19th International Aspergillus Meeting Asperfest 19　2023/03/04
DNA-binding sequences of the transcription factor FlbC involved in the regulation of Aspergillus oryzae genes specifically expressed in solid-state culture

Ohnuma T, Arai H, Kojima K, Hidaka M, Shintani T, Gomi K

The 19th International Aspergillus Meeting Asperfest 19　2023/03/04
Effect of the transcription factor AsFlbC deletion on enzyme production in solid state culture in Aspergillus sojae

Fujita S, Katayama T, Maruyama J, Shintani T, Gomi K

The 19th International Aspergillus Meeting Asperfest 19　2023/03/04
黒麹菌Aspergillus luchuensis とその近縁種におけるAmyRの特性解明

森瀬太一, 橋本渉, 塚原正俊, 水谷治, 山田修, 渡部昭, 藤田翔貴, 新谷尚弘, 五味勝也

日本農芸化学会2023年度（令和5年度）大会　2023
醤油麹菌Aspergillus sojaeにおける転写因子AsFlbCの固体培養特異的な酵素生産への影響

藤田翔貴, 片山琢也, 丸山潤一, 新谷尚弘, 五味勝也

第21回糸状菌分子生物学コンファレンス　2022/11/24
異種分泌タンパク質遺伝子導入による麹菌の生育ストレスの解析

開田有紗, 三澤恒汰, 五味勝也, 新谷尚弘

第21回糸状菌分子生物学コンファレンス　2022/11/24
麹菌におけるRIDD低減株造成を目指したIreAの機能解析

横山将己, 五味勝也, 新谷尚弘

第21回糸状菌分子生物学コンファレンス　2022/11/24
The cis-element analysis of the transcription factor FlbC involved in solid-state culture-specific gene expression in Aspergillus oryzae

2022/03/18
The deubiquitinating enzyme CreB regulates gene expression and protein stability of CreD in Aspergillus oryzae

2022/03/18
Difference in amylase production regulatory fashions in Aspergillus luchuensis and its closely related species

2022/03/18
Accumulation and assimilation process of maltose that inhibits the growth of the malT deletion mutant in Aspergillus oryzae .

Yahong Zou, Silai Zhang, Akira Watanabe, Shoki Fujita, Takahiro Shintani, Katsuya Gomi

2022/03/15
麹菌においてカーボンカタボライト抑制を制御する脱ユビキチン化酵素CreBはユビキチンリガーゼアダプターCreDの転写誘導とタンパク質安定性を制御する Invited

田中瑞己, 藤田翔貴, 河原崎泰昌, 山形洋平, 新谷尚弘, 五味勝也

第20回糸状菌分子生物学コンファレンス　2021/11/11
黒麹菌Aspergillus luchuensisとその近縁種におけるアミラーゼ生産制御機構の解析 Invited

森瀬太一, 橋本渉, 渡部昭, 水谷治, 山田修, 新谷尚弘, 五味勝也

第20回糸状菌分子生物学コンファレンス　2021/11/11
出芽酵母ロンボイドPcp1pの生理機能解明と基質探索

角田俊揮, 日高將文, 小川智久, 新谷尚弘, 二井勇人

日本農芸化学会2021年度大会　2021/03/20
Functional analysis of maltose utilization related genes in Aspergillus oryzae

Zou Yahong, Zhan Sitong, Shintani Takahiro, Gomi Katsuya

2021/03/19
出芽酵母グリセロール輸送体Stl1のグルコース不活性化に必要なα-アレスチンRod1によるStl1認識領域の探索

藤田翔貴, 五味勝也, 新谷尚弘

日本農芸化学会2021年度大会　2021/03/19
「天狗の麦飯」から分離されたクテドノバクテリア Dictyobacter alpinus Uno16 からの抗菌化合物の探索

齋藤彩菜, 白石太郎, 葛山智久, 新谷尚弘, 工藤雄大, 山下まり, 阿部敬悦, 横田明, 矢部修平

日本農芸化学会2021年度大会　2021/03/19
麹菌におけるカーボンカタボライト抑制を制御する脱ユビキチン化酵素CreB によるアレスチン様タンパク CreD の発現制御

田中瑞己, 藤田翔貴, 河原崎, 泰昌, 新谷, 尚弘, 五味勝也

日本農芸化学会2021年度大会　2021/03/20
5'CAGEデータに基づくAspergillus属真菌間の解糖系酵素遺伝子群における転写開始点の比較解析

井上大志, 新谷尚弘, 五味勝也

第19回糸状菌分子生物学コンファレンス　2019/11/06
麹菌における小胞体ターゲティングに依存した分泌タンパク質mRNAの品質管理

佐藤駿, 杉山優子, 田中瑞己, 五味勝也, 新谷尚弘

第19回糸状菌分子生物学コンファレンス　2019/11/06
麹菌のGH1に属するグルコース耐性を有した新規β-グルコシダーゼの酵素学的諸性質

渡部昭, 新谷尚弘, 五味勝也

第19回糸状菌分子生物学コンファレンス　2019/11/06
麹菌マルトース輸送体MalPのエンドサイトーシスにはアレスチン様因子CreDのユビキチン化が必要である

藤田翔貴, 多田日菜子, 田中瑞己, 新谷尚弘, 五味勝也

第19回糸状菌分子生物学コンファレンス　2019/11/06
黒麹菌 Aspergillus luchuensis における転写因子 AmyRの活性化機構の解析

橋本渉, 渡部昭, 水谷治, 山田修, 新谷尚弘, 五味勝也

第19回糸状菌分子生物学コンファレンス　2019/11/06
出芽酵母におけるYkt6とNyv1の液胞輸送経路における機能重複

久保優里花, 浦野真吾, 五味勝也, 新谷尚弘

第12回オートファジー研究会　2019/10/25
出芽酵母のリン酸飢餓誘導性オートファジーにおけるAtg11とSlt2の役割の解析

奥村俊, 横田浩人, 五味勝也, 新谷尚弘

第12回オートファジー研究会　2019/10/25
Ykt6とNyv1の液胞輸送経路における機能重複

浦野真吾, 久保優里花, 五味勝也, 新谷尚弘

酵母遺伝学フォーラム第52回研究報告会　2019/09/04
Enzymatic properties of a novel β-glucosidase (BglU/Bgl5) from Aspergillus oryzae overexpressed in Escherichia coli

2019/03/27
Different usage of alternative TSSs in enolase-encoding gene between Aspergillus oryzae and Aspergillus nidulans

2019/03/27
Subcellular localization and post-transcriptional modification of transcription factor FlbC involved in the transcriptional regulation of Aspergillus oryzae genes specifically expressed in solid-state culture

2019/03/24
Analysis of how transcription of secretory protein gene is repressed under endoplasmic reticulm stress in Aspergillus oryzae

2019/03/24
出芽酵母のリン酸飢餓誘導性オートファジーにおけるAtg11の役割の解析と特異的因子の発見

奥村俊, 横田浩人, 五味勝也, 新谷尚弘

日本農芸化学会2019年度大会　2019/03/24
黒麹菌Aspergillus luchuensisにおけるアミラーゼ遺伝子の発現制御機構解析

橋本渉, 荒井啓, 水谷治, 山田修, 新谷尚弘, 五味勝也

第70回日本生物工学会大会　2018/09/10
小胞体から漏出し、高マンノース型外糖鎖が付加される出芽酵母カルボキシペプチターゼY (CPY) 変異体の解析

高橋俊貴, 堀瑞枝, 須山研吾, 五味勝也, 新谷尚弘

第51回酵母遺伝学研究会フォーラム　2018/09/10
麹菌における環境応答性MAPキナーゼ転写因子経路のGlaB遺伝子発現制御への関与

荒井啓, 田中瑞己, 吉村緑, 新谷尚弘, 五味勝也

第70回日本生物工学会大会　2018/09/05
Role of the C-terminal region of yeast monocarboxylate transporter Jen1 in its glucoseinduced and ubiquitination-dependent inactivation by α-arrestin Rod1 International-presentation

Shoki Fujta, Katsuya Gomi, Takahiro Shintani

2018 Yeast Genetic Meeting　2018/08/23
Functional analysis of Ykt6 in autophagic process International-presentation

Shingo Urano, Nozomi Kikuchi, Katsuya Gomi, oTakahiro Shintani

2018 Yeast Genetic Meeting　2018/08/23
出芽酵母モノカルボン酸輸送体Jen1のグルコース不活性化におけるαーアレスチンRod1による認識とユビキチン化制御機構の解析

藤田翔貴, 五味勝也, 新谷尚弘

日本農芸化学会2018年度大会　2018/03/16
出芽酵母オートファジーにおけるYkt6のオートファゴソームと液胞の融合への関与

浦野真吾, 菊地のぞみ, 五味勝也, 新谷尚弘

日本農芸化学会2018年度大会　2018/03/16
麹菌のカーボンカタボライト抑制転写因子CreAによる液体培養時の菌糸形態の制御

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2018年度大会　2018/03/16
ゲノムマイニングによって取得した麹菌由来の新規キシラナーゼ(XynB)の酵素学的諸性質

渡部昭, 小幡公平, 太田夏野子, 氏家成隆, 新谷尚弘, 五味勝也

日本農芸化学会2018年度大会　2018/03/16
Comparative analysis for transcription start sites of enolase gene in Aspergillus oryzae and Aspergillus nidualns International-presentation Invited

○Taishi Inoue, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

14th European conference on Fungal Genetics　2018/02/26
麹菌における環境ストレス応答性MAPキナーゼのglaB遺伝子発現への関与

荒井啓, 田中瑞己, 吉村緑, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16
麹菌マルトーストランスポーターMalP分解時のユビキチン化リジン残基の同定

多田日菜子, 田中瑞己, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-16
麹菌におけるアレスチン様タンパク質CreDによるグルコース誘導性エンドサイトーシスとカーボンカタボライト抑制の制御

田中瑞己, 平本哲也, 多田日菜子, 一瀬桜子, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-38
麹菌クチナーゼ様エステラーゼCutCの示す特徴的な酵素学的諸性質

小幡公平, 山岸純也, 新谷智子, 渡部昭, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-46
麹菌 Aspergillus oryzae とその近縁種のエノラーゼ遺伝子における転写開始点の比較解析

井上大志, 田中瑞己, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-53
麹菌におけるカーボンカタボライト抑制因子 CreA の有機酸生産制御への関与

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-54
麹菌アゾール系薬剤耐性に関与する転写因子 AtrR の cis-element 解析

長野晋雄, 大場歩, 萩原大祐, 田中瑞己, 新谷尚弘, 川本進, 五味勝也

第17回糸状菌分子生物学コンファレンス　2017/11/16

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P-63
麹菌の固体培養における転写因子 FlbC のプロテアーゼ遺伝子の発現制御への関与

荒井啓, 田中瑞己, 吉村緑, 新谷尚弘, 五味勝也

第69回日本生物工学会大会　2017/09/11
麹菌におけるカーボンカタボライト抑制転写因子 CreA による有機酸生産制御

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第69回日本生物工学会大会　2017/09/11
麹菌のクチナーゼ様エステラーゼ CutC が示す特徴的な酵素学諸性質

小幡公平, 山岸純也, 竹内俊輔, 新谷智子, 渡部昭, 新谷尚弘, 阿部敬悦, 五味勝也

第69回日本生物工学会大会　2017/09/11
出芽酵母モノカルボン酸輸送体をコードする JEN1 遺伝子 mRNA のグルコースに応答した翻訳抑制における 3’ 非翻訳領域の寄与

高橋俊貴, 竹腰祐太郎, 五味勝也, 新谷尚弘

第50回酵母遺伝学研究会フォーラム　2017/09/11
Rsp5 アダプタータンパク質 Art4 によるモノカルボン酸輸送体 Jen1 C-tail 認識と標的のユビキチン化制御機構の解析

藤田翔貴, 五味勝也, 新谷尚弘

第50回酵母遺伝学研究会フォーラム　2017/09/11
オートファゴソームと液胞の融合における Ykt6 の関与

浦野真吾, 菊地のぞみ, 五味勝也, 新谷尚弘

第50回酵母遺伝学研究会フォーラム　2017/09/11
Expression of an AT -biased Rhizopus glucoamylase gene in Aspergillus oryzae using codon optimization International-presentation

Dalia Zawil, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

29th Fungal Genetics Conference　2017/03/14
Intron within 5′ untranslated region enhances transcription of the enolase-encoding gene (enoA) in Aspergillus oryzae International-presentation

Taishi Inoue, Hiroki Toji, Mitsuru Takama, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

29th Fungal Genetics Conference　2017/03/14
Subcellular localization and stability of deubiquitinase CreB involved in carbon catabolite repression in Aspergillus oryzae International-presentation

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

14th International Aspergillus Meeting (Asperfest14)　2017/03/13
Intron within 5′ untranslated region enhances transcription of the enolase-encoding gene (enoA) in Aspergillus oryzae International-presentation

Taishi Inoue, Hiroki Toji, Mitsuru Takama, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

14th International Aspergillus Meeting (Asperfest14)　2017/03/13
Functional and subcellular localization analyses of transcription factors, AtrR and SrbA, involved in azole drug resistance in Aspergillus oryzae International-presentation

Kohei Sugiyama, Ayumi Ohba-Tanaka, Daisuke Hagiwara, Susumu Kawamoto, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

14th International Aspergillus Meeting (Asperfest14)　2017/03/13
Functional and subcellular localization analyses of transcription factors, AtrR and SrbA, involved in azole drug resistance in Aspergillus oryzae International-presentation

Kohei Sugiyama, Ayumi Ohba-Tanaka, Daisuke Hagiwara, Susumu Kawamoto, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

29th Fungal Genetics Conference　2017/03/13
Relationship between stability and subcellular localization of carbon catabolite repression regulator, CreA, in Aspergillus oryzae International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

29th Fungal Genetics Conference　2017/03/13
Identification of regions of plasma membrane transporter Jen1 recognized by Rsp5 adopter proteins in its vacuolar trafficking pathways International-presentation

Shoki Fujita, Katsuya Gomi, Takahiro Shintani

14th International Congress on yeast　2016/09/11
膜輸送体Jen1の分解に関与するRsp5アダプターのJen1認識領域の探索

藤田翔貴, 五味勝也, 新谷尚弘

第49酵母遺伝学フォーラム　2016/09/09
SUMO依存性ユビキチンライゲースによるヒストンバリアントH2A.Zの量的制御

高橋大輔, 日下部将之, 折原行希, 北川紗帆, 新谷尚弘, 小間由佳子, 原田昌彦

第49酵母遺伝学フォーラム　2016/09/09
Polysaccharides composition of the cell wall of Aspergillus oryzae disruptants of genes involved in carbon catabolite repression International-presentation

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

13th European Conference on Fungal Genetics (ECFG13)　2016/04/03
FlbC is involved in transcriptional regulation of Aspergillus oryzae glucoamylase and protease genes specifically expressed in solid-state culture International-presentation

Mizuki Tanaka, Midori Yoshimura, Masahiro Ogawa, Yasuji Koyama, Takahiro Shintani, Katsuya Gomi

13th European Conference on Fungal Genetics (ECFG13)　2016/04/03
Polysaccharides composition of the cell wall of Aspergillus oryzae disruptants of genes involved in carbon catabolite repression International-presentation

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

13th International Aspergillus Meeting (Asperfest13)　2016/04/02
FlbC is involved in transcriptional regulation of Aspergillus oryzae glucoamylase and protease genes specifically expressed in solid-state culture International-presentation

Mizuki Tanaka, Midori Yoshimura, Masahiro Ogawa, Yasuji Koyama, Takahiro Shintani, Katsuya Gomi

13th International Aspergillus Meeting (Asperfest13)　2016/04/02
麹菌カーボンカタボライト抑制制御因子CreAの炭素源異存的なリン酸化と細胞内局在変化

田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2016年度大会　2016/03/27
麴菌のグルコース抑制関連因子遺伝子破壊株における二次代謝産物生産性

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2016年度大会　2016/03/27
麹菌における選択的転写開始機構を有する解糖系遺伝子プロモーターのシスエレメント解析

井上大志, 田路洋紀, 高間充, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2016年度大会　2016/03/27
麹菌細胞壁成分のコウジ酸生産への影響

張斯来, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2016年度大会　2016/03/27
グルコースにより不活性化される酵母膜輸送体Jen1のアレスチン様タンパク質Art4による認識領域の解析

藤田翔貴, 五味勝也, 新谷尚弘

第38回日本分子生物学会年会・第88回日本生物学会大会合同大会　2015/12/01
出芽酵母の選択的オートファジーに必要なアダプタータンパク質Atg11はリン酸飢餓で起こるバルクオートファジーにも関与する

横田浩人, 五味勝也, 新谷尚弘

第38回日本分子生物学会年会・第88回日本生物学会大会合同大会　2015/12/01
麹菌における炭素源依存的な選択的転写開始機構えお有する解糖系遺伝子の同定

井上大志, 田路洋紀, 高間充, 田中瑞己, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
麹菌カーボンカタボライト抑制関連遺伝子破壊株の細胞壁構成多糖の成分解析

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
麹菌細胞壁のα-1,3-グルカンは液体培養におけるタカアミラーゼの細胞壁吸着性に関与する

張斯来, 田中瑞己, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
麴菌のアミラーゼ遺伝子を制御する転写因子AmyRの各種炭素源における細胞内局在解析

今野友維, 鈴木空太, 田中瑞己, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
麹菌カーボンカタボライト抑制制御因子CreAの細胞内局在と安定性

田中瑞己, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
麴菌における菌体内α=グルコシダーゼMalTのアミラーゼ誘導生産への関与

渡邊崇健, 市川昂典, 長谷川-城祥子, 田中瑞己, 渡部昭, 新谷尚弘, 五味勝也

第15回糸状菌分子生物学コンファレンス　2015/11/19
出芽酵母の選択的オートファジーに必要なアダプタータンパク質Atg11はリン酸飢餓で起こるバルクオートファジーにも関与する

第9回オートファジー研究会　2015/11/15

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発表日 2015年11月16日
麹菌におけるグルコース抑制関連因子遺伝子破壊株による液体培養時の形態変化

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第67回日本生物工学会大会　2015/10/26
麹菌解糖系遺伝子における選択的転写開始と5'非翻訳領域のイントロン機能の解析

井上大志, 田路洋紀, 高間充, 田中瑞己, 新谷尚弘, 五味勝也

第67回日本生物工学会大会　2015/10/26
麹菌のアミラーゼ誘導生産における菌体内α-グルコシダーゼMalTの重要性

渡辺崇健, 市川昂典, 長谷川-城祥子, 田中瑞己, 渡部昭, 新谷尚弘, 五味勝也

第67回日本生物工学会大会　2015/10/26
炭素源が麹菌のカーボンカタボライト抑制制御因子 CreA の細胞内局在と安定性に与える影響

田中瑞己, 新谷尚弘, 五味勝也

第67回日本生物工学会大会　2015/10/26
麹菌のalpha-1,3-グルカン生合成酵素遺伝子の高発現による形態及びタカアミラーゼ細胞壁吸着への影響

張斯来, 田中瑞己, 新谷尚弘, 五味勝也

第67回日本生物工学会大会　2015/10/26
Identification of Regions in Monocarboxylic Acid Transporter Jen1 Requisite for Its Glucose-Induced Degradation and Recognition by Rsp5 Adaptor Rod1 International-presentation

Takahiro Shintani, Shoki Fujita, Katsuya Gomi

27th International Conference on Yeast Genetics and Molecular Biology　2015/09/06
Non-selective Autophagy Induced by Phosphate Starvation Requires Atg11 and Is Regulated by TORC1 Signaling Pathway in Saccharomyces cerevisiae International-presentation

Hiroto Yokota, Katsuya Gomi, Takahiro Shintani

27th International Conference on Yeast Genetics and Molecular Biology　2015/09/06
Rsp5アダプタータンパク質Art4のモノカルボン酸輸送体Jen1認識ドメインの探索

藤田翔貴, 五味勝也

酵母遺伝学フォーラム第48回研究報告会　2015/08/31
グルコース抑制における3'UTRが担う役割の解析

竹越祐太郎, 五味勝也

酵母遺伝学フォーラム第48回研究報告会　2015/08/31
出芽酵母のリン酸飢餓応答におけるオートファジー誘導の役割とその制御機構の解析

横田浩人, 五味勝也, 新谷尚弘

日本農芸化学会2015年度大会　2015/03/26
出芽酵母オートファジーにおけるSNAREタンパク質の役割

菊地のぞみ, 柚賀正樹, 源田博, 五味勝也, 新谷尚弘

日本農芸化学会2015年度大会　2015/03/26
小胞体ストレス応答は麴菌のアミラーゼ高生産条件下での生育に必須である

田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
麹菌マルトースパーミアーゼ分解におけるアレスチン様タンパク質CreDの脱リン酸化の関与

松浦優佳, 田中瑞己, 平本哲也, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
転写産物の安定化によるモノカルボン酸輸送体遺伝子JEN1のグルコース抑制の遅延

竹越祐太郎, 松本耕助, 五味勝也, 新谷尚弘

日本農芸化学会2015年度大会　2015/03/26
出芽酵母モノカルボン酸輸送体Jen1のグルコース不活性化に必要なアレスチン様タンパク質Art4によるJen1認識領域の探索

藤田翔貴, 五味勝也, 新谷尚弘

日本農芸化学会2015年度大会　2015/03/26
麹菌解糖系遺伝子の選択的転写開始に関わるプロモーターと5′非翻訳領域の解析

井上大志, 田路洋紀, 高間充, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
固体培養特異的発現を示す麹菌のグルコアミラーゼ遺伝子（glaB）の発現を制御する転写因子FlbCの機能

吉村緑, 田中瑞己, 小川真弘, 小山泰二, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
麹菌の転写因子AtrRとSrbAのアゾール系薬剤耐性への関与と細胞内局在解析

杉山航平, 大場歩, 萩原大祐, 田中瑞己, 新谷尚弘, 川本進, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
麹菌のアミラーゼ誘導生産におけるマルトース資化遺伝子 (MAL) クラスターの役割

市川昂典, 長谷川-城祥子, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
麹菌のカーボンカタボライト抑制関連因子 CreA・CreB 二重破壊株はセルロース系バイオマス分解酵素も高生産する

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2015年度大会　2015/03/26
Activation mechanisms of two transcription factors, AmyR and MalR, involved in amylolytic enzyme production in Aspergillus oryzae International-presentation

◯Mizuki Tanaka, Kuta Suzuki, Takanori Ichikawa, Yui Konno, Sakurako Ichinose, Sachiko Hasegawa-Shiro, Takahiro Shintani, Katsuya Gomi

28th Fungal Genetics Conference　2015/03/17
Hyperproduction of biomass-degrading enzymes by double deletion of CreA and CreB involved in carbon catabolite repression in Aspergillus oryzae International-presentation

Sakurako Ichinose, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

12th International Aspergillus Meeting (Asperfest12)　2015/03/16
Stabilization of carbon catabolite repression regulator CreA under the activation condition in Aspergillus oryzae International-presentation

◯Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

12th International Aspergillus Meeting (Asperfest12)　2015/03/16
Effects of α-1,3-glucan synthase gene knockout on α-amylase adsorption onto the cell wall and productivity of enzymes and metabolites in Aspergillus oryzae International-presentation

◯Silai Zhang, Mizuki Tanaka, Hiroki Sato, Takahiro Shintani, Katsuya Gomi

12th International Aspergillus Meeting (Asperfest12)　2015/03/16
麹菌の転写因子 FlbC は固体培養特異的発現を示すグルコアミラーゼ遺伝子 (glaB) の発現を制御する

吉村緑, 田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
カーボンカタボライト抑制制御因子 CreA は活性化条件において安定化する

田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
麹菌のアミラーゼ生産に関与する転写因子の各種炭素源における細胞内局在解析

今野友維, 鈴木空太, 田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
麹菌におけるグルコース抑制関連因子遺伝子破壊株を宿主とした異種遺伝子高発現

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15

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キッコーマン特別賞受賞
麹菌細胞壁の α-グルカン合成に関わる多重遺伝子破壊株の形態および物質生産特性

張斯来, 田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
麹菌マルトース資化遺伝子クラスターのアミラーゼ誘導生産への関与

市川昂典, 長谷川-城祥子, 田中瑞己, 新谷尚弘, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
麹菌のエルゴステロール生合成を制御する転写因子 AtrR と SrbA の機能および細胞内局在解析

杉山航平, 大場歩, 萩原大祐, 田中瑞己, 新谷尚弘, 川本進, 五味勝也

第14回糸状菌分子生物学コンファレンス　2014/11/15
麹菌マルトース資化遺伝子クラスターのアミラーゼ誘導生産への関与

市川昂典, 長谷川-城幸子, 田中瑞己, 新谷尚弘, 五味勝也

平成26年度日本農芸化学会北海道支部・東北支部合同支部大会　2014/09/22
麹菌の固体培養特異的発現を示すグルコアミラーゼ遺伝子（ glaB ）の発現制御に関与する転写因子

吉村緑, 田中瑞己, 新谷尚弘, 五味勝也

第66回日本生物工学会大会　2014/09
選択マーカーリサイクリングシステムにより得られた麹菌 alpha-グルカン合成に関わる多重遺伝子破壊株の特性

張斯来, 田中瑞己, 新谷尚弘, 五味勝也

第66回日本生物工学会大会　2014/09
炭素源およびユビキチン／脱ユビキチン化因子の麹菌 CreA タンパク質安定性への関与

田中瑞己, 新谷尚弘, 五味勝也

第66回日本生物工学会大会　2014/09
麹菌におけるグルコース抑制関連因子遺伝子破壊株を宿主とした異種遺伝子高発現

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第66回日本生物工学会大会　2014/09
麹菌のアミラーゼ生産に関与する転写因子の細胞内局在解析

今野友維, 鈴木空太, 田中瑞己, 新谷尚弘, 五味勝也

第66回日本生物工学会大会　2014/09
リン酸飢餓におけるオートファジーの役割と誘導メカニズムの解析

横田浩人, 五味勝也

酵母遺伝学フォーラム第47回研究報告会　2014/09/01
グルコースに応答したモノカルボン酸輸送体Jen1の減少におけるCcr4-Not複合体の役割

竹越祐太郎, 五味勝也

酵母遺伝学フォーラム第47回研究報告会　2014/09/01
モノカルボン酸輸送体Jen1のエンドサイトーシスにおけるRsp5アダプタータンパク質Art4によるJen1認識機構の解析

藤田翔貴, 五味勝也

酵母遺伝学フォーラム第47回研究報告会　2014/09/01
麹菌マルトースパーミアーゼ分解におけるユビキチン化マシナリーの作用機構

松浦優佳, 田中瑞己, 平本哲也, 五味勝也

日本農芸化学会2014年度大会　2014/03/27
麹菌における自己切断型Cre/loxP選択マーカーリサイクリングカセットを利用した多重遺伝子導入・破壊システム

張, 伴暁彦, 江原直樹, 水谷治, 田中瑞己, 五味勝也

日本農芸化学会2014年度大会　2014/03/27
麹菌アレスチン様タンパク質CreDの翻訳後修飾の解析とカーボンカタボライト脱抑制への関与

田中瑞己, 平本哲也, 五味勝也

日本農芸化学会2014年度大会　2014/03/27
麴菌の固体培養特異的遺伝子発現制御に関わる転写因子の探索

吉村緑, 田中瑞己, 五味勝也

日本農芸化学会2014年度大会　2014/03/27
麹菌でアフィディコリンを異種高発現させるための生合成酵素の細胞内局在解析

伴暁彦, 田中瑞己, 藤居, 南篤志, 及川英秋, 五味勝也

日本農芸化学会2014年度大会　2014/03/27
Involvement of ubiquitination machinery in endocytic degradation of maltose transporter (MalP) in Aspergillus oryzae International-presentation

Yuka Matsuura, Mizuki Tanaka, Tetsuya Hiramoto, Takahiro Shintani, ○Katsuya Gomi

12th European Conference on Fungal Genetics (ECFG12)　2014/03/23
Effect of single and double deletion of genes involved in carbon catabolite repression on amylase production in Aspergillus oryzae, International-presentation

○Mizuki Tanaka, Sakurako Ichinose, Takahiro Shintani, Katsuya Gomi

12th European Conference on Fungal Genetics (ECFG12)　2014/03/23
Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae International-presentation

Silai Zhang, Akihiko Ban, Osamu Mizutani, Mizuki Tanaka, Takahiro Shintani, ○Katsuya Gomi

11th International Aspergillus Meeting (Asperfest11)　2014/03/22
Regulation of carbon catabolite derepression through dephosphorylation of arrestin-like protein CreD in Aspergillus oryzae International-presentation

Mizuki Tanaka, Tetsuya Hiramoto, Takahiro Shintani, Katsuya Gomi

11th International Aspergillus Meeting (Asperfest11)　2014/03/22
麹菌アレスチン様タンパク質 CreD の脱リン酸化によるグルコース抑制の制御

田中瑞己, 平本哲也, 新谷尚弘, 五味勝也

第13回糸状菌分子生物学コンファレンス　2013/11/20
麹菌における自己切断型 Cle/loxP 選択マーカーリサイクリングシステムの確立

張斯来, 伴曉彦, 江原直樹, 水谷治, 田中瑞己, 五味勝也

第13回糸状菌分子生物学コンファレンス　2013/11/20
麹菌で異種発現させたアフィディコリン生合成酵素の細胞内局在解析

第13回糸状菌分子生物学コンファレンス　2013/11/20
麹菌マルトースパーミアーゼ分解における HECT ユビキチンリガーゼ HulA の関与

第13回糸状菌分子生物学コンファレンス　2013/11/20
麹菌のカーボンカタボライト抑制関連因子 CreA・CreB 二重破壊によるアミラーゼ高生産

一瀬桜子, 田中瑞己, 五味勝也

第13回糸状菌分子生物学コンファレンス　2013/11/20
麹菌の転写因子 AmyR と MalR の翻訳後修飾と安定性

鈴木空太, 田中瑞己, 五味勝也

第13回糸状菌分子生物学コンファレンス　2013/11/20
Improved amylase production by Aspergillus oryzae after a double deletion of genes involved in carbon catabolite repression International-presentation

◯Mizuki Tanaka, Sakurako Ichinose, Takahiro Shintani, Katsuya Gomi

iBioB2013　2013/10/20
Unconventional splicing of hacA intron is essential for growth of Aspergillus oryzae under induction condition of amylolytic gene expression International-presentation

◯Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

XI International Fungal Biology Conference　2013/09/29
麹菌におけるアレスチン様タンパク質 CreD のグルコース抑制への関与

田中瑞己, 平本哲也, 五味勝也

第65回日本生物工学会大会　2013/09/18
麹菌のアミラーゼ生産に関与する転写因子の翻訳後修飾

鈴木空太, 田中瑞己, 五味勝也

第65回日本生物工学会大会　2013/09/18
麹菌のグルコース抑制関連因子遺伝子破壊株におけるアミラーゼ高生産

一瀬桜子, 田中瑞己, 五味勝也

第65回日本生物工学会大会　2013/09/18
麹菌におけるイントロン導入 Cre を用いた自己切断型選択マーカーリサイクリングシステムの構築

張斯来, 伴曉彦, 水谷治, 田中瑞己, 新谷尚弘, 五味勝也

第65回日本生物工学会大会　2013/09/18
出芽酵母におけるリン酸飢餓誘導性オートファジーの解析

横田浩人, 五味勝也

酵母遺伝学フォーラム第46回研究報告会　2013/09/08
The expression of ABC transporter genes and ergosterol biosynthetic genes is regulated by the Zn2Cys6 transcription factor AtrR in Aspergillus fungi International-presentation

Ayumi Ohba, Daisuke Hagiwara, Kiminori Shimizu, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

5th Congress of European Microbiologists (FEMS 2013)　2013/07/21
THE EXPRESSION OF ABC TRANSPORTER GENES AND ERGOSTEROL BIOSYNTHETIC GENES IS REGULATED BY THE ZN2CYS6 TRANSCRIPTION FACTOR ATRR IN ASPERGILLUS FUNGI. International-presentation

A.Ohba, D. Hagiwara, K. Shimizu, T. Shintani, K. Kawamoto, K. Gomi

FEMS2013　2013/07/21
出芽酵母モノカルボン酸輸送体Jen1のグルコース誘導性分解制御因子の探索と解析

松本耕助, 葛西寛一, 大橋優隆, 机伸太郎, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
出芽酵母におけるリン酸飢餓誘導性オートファジーの解析：液胞内リン酸プールとオートファジー誘導の関係

横田浩人, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
麹菌アレスチン様タンパク質CreDのマルトースパーミアーゼのエンドサイトーシスへの影響

平本哲也, 田中瑞己, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
麹菌における自己切断型選択マーカーカセットを用いた多重遺伝子導入システムの構築

張斯来, 江原直樹, 水谷治, 田中瑞己, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
麹菌で異種発現させたアフィディコリン生合成酵素の細胞内局在解析

伴暁彦, 田中瑞己, 藤居, 及川英秋, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
麹菌における炭素源依存的なCreAタンパク質量の制御

田中瑞己, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
Aspergillusの転写因子AtrRは薬剤排出ABCトランスポーター遺伝子とエルゴステロール生合成酵素遺伝子の発現を制御する

大場歩, 清水公徳, 萩原大祐, 川本進, 五味勝也

日本農芸化学会2013年度大会　2013/03/24
麴菌のカタボライト抑制制御マシナリーの機能制御によるアミラーゼ生産向上

五味勝也, 田中瑞己, 一瀬桜子

日本農芸化学会2013年度大会　2013/03/24
Maltose permease-encoding mRNA is cleaved under induction condition of amylolytic gene expression in Aspergillus oryzae International-presentation

○Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

27th Fungal Genetics Conference　2013/03/12
Subcellular localization of aphidicolin biosynthesis enzymes from Phoma betae expressed heterologously in Aspergillus oryzae International-presentation

Akihiko Ban, Mizuki Tanaka, Ryuya Fujii, Atsushi Minami, Hideaki Oikawa, Takahiro Shintani, ○Katsuya Gomi

27th Fungal Genetics Conference　2013/03/12
The transcription factor, AtrR, regulates the expression of ABC transporter genes and ergosterol biosynthesis genes in aspergilli International-presentation

○Ayumi Ohba, Kiminori Shimizu, Daisuke Hagiwara, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

27th Fungal Genetics Conference　2013/03/12
Multiple gene integration system using a self-excisable marker cassette in Aspergillus oryzae International-presentation

Silai Zhang, Naoki Ebara, Osamu Mizutani, Mizuki Tanaka, Takahiro Shintani, ○Katsuya Gomi

10th International Aspergillus Meeting (Asperfest10)　2013/03/11
The transcription factor, AtrR, regulates the expression of ABC transporter genes and ergosterol biosynthesis genes in aspergilla International-presentation

○Ayumi Ohba, Kiminori Shimizu, Daisuke Hagiwara, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

10th International Aspergillus Meeting (Asperfest10)　2013/03/11
Effect of carbon sources on CreA protein level in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

10th International Aspergillus Meeting (Asperfest10)　2013/03/11
麹菌のカーボン化タボライト抑制マシナリーの機能制御によるアミラーゼ生産性向上

五味勝也, 田中瑞己, 一瀬桜子, 新谷尚弘

日本農芸化学会2013年度大会　2013/03
糸状菌の二次代謝産物生合成酵素の細胞内局在解析

伴曉彦, 田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
麹菌における CreA タンパク質量の翻訳後過程における制御

田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
麹菌における CreA 及び脱ユビキチン化酵素 CreB 破壊によるグルコース抑制の解除

一瀬桜子, 田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
麹菌 A. oryzae のデンプン分解酵素生産に関与する転写因子の細胞内局在解析

鈴木空太, 田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
麹菌グルコース抑制関連遺伝子 creD の MalP のエンドサイトーシスへの関与

平本哲也, 田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11

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学生ポスター賞受賞
麹菌における Cre-loxP 選択マーカーリサイクリングシステムの改良

張斯来, 江原直樹, 水谷治, 田中瑞己, 新谷尚弘, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
AtrR は Aspergillus fumigatus においてエルゴステロール合成系遺伝子発現を制御する

大場歩, 清水公徳, 萩原大祐, 新谷尚弘, 川本進, 五味勝也

第12回糸状菌分子生物学コンファレンス　2012/11
麹菌における脱ユビキチン化酵素 CreB 破壊によるグルコース抑制の解除

田中瑞己, 新谷尚弘, 五味勝也

第64回日本生物工学会大会　2012/10
麹菌の AmyR と MalR の細胞内局在と制御下遺伝子の発現解析

鈴木空太, 田中瑞己, 新谷尚弘, 五味勝也

第147回日本農芸化学会東北支部大会　2012/10
麹菌のエノラーゼ遺伝子における選択的転写開始に関与する配列の探索

田路洋紀, 高間充, 新谷尚弘, 五味勝也

第147回日本農芸化学会東北支部大会　2012/10
出芽酵母におけるリン酸代謝とオートファジーの関連性

横田浩人, 五味勝也, 新谷尚弘

第147回日本農芸化学会東北支部大会　2012/10
出芽酵母におけるリン酸代謝とオートファジーの関連性

酵母遺伝学フォーラム第45回研究報告会　2012/09/04
ESCRT変異によるオートファジー非依存的な液胞分解経路の活性化

一迫直也, 松浦優佳, 五味勝也

酵母遺伝学フォーラム第45回研究報告会　2012/09/04
Transcripts of a heterologous gene are stabilized by codon optimization in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Masafumi Tokuoka, Takahiro Shintani, Katsuya Gomi

The 6th Japan-Finland Biotechnology Symposium　2012/06/04
Subcellular localization of maltose permease (MalP) in response to carbon sources in Aspergillus oryzae. International-presentation

Tetsuya Hiramoto, Mizuki Tanaka, Ryoko Daidoguchi, Takahiro Shintani, Katsuya Gomi

11th European Conference on Fungal Genetics (ECFG11)　2012/03/30
Functional analysis of Hsp70 family protein SsaA in Aspergillus oryzae. International-presentation

Ayumi Ohba, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

11th European Conference on Fungal Genetics (ECFG11)　2012/03/30
Effect of conditional expression of CreA and HECT ubiquitin ligase HulA on glucose repression in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

11th European Conference on Fungal Genetics (ECFG11)　2012/03/30
Characterization of farA and other zinc finger transcription factor genes for fatty acid metabolism in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

11th European Conference on Fungal Genetics (ECFG11)　2012/03/30
Pleiotropic effects of farA disruption in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

9th International Aspergillus Meeting (Asperfest9)　2012/03/29
Transcript of heterologous gene is stabilized by codon optimization of premature polyadenylated region in A. oryzae. International-presentation

Mizuki Tanaka, Masafumi Tokuoka, Takahiro Shintani, Katsuya Gomi

9th International Aspergillus Meeting (Asperfest9)　2012/03/29
Functional analysis of Hsp70 family protein SsaA in A. oryzae. International-presentation

Ayumi Ohba, Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

9th International Aspergillus Meeting (Asperfest9)　2012/03/29
Multiple gene expression system by means of Cre/loxP-mediated marker recycling with mutated loxP sites in Aspergillus oryzae. International-presentation

Naoki Ebera, Osamu Mizutani, Takahiro Shintani, Katsuya Gomi

9th International Aspergillus Meeting (Asperfest9)　2012/03/29
麹菌のグルコース抑制遺伝子変異株におけるマルトースパーミアーゼのエンドサイトーシス

平本哲也, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2012年度大会　2012/03
麹菌由来β-グルコシダーゼの配糖体分解活性および発現誘導解析

工藤佳那子, 氏家成隆, 渡部昭, 新谷尚弘, 五味勝也

日本農芸化学会2012年度大会　2012/03
麹菌の薬剤排出ABCトランスポーターを制御する転写因子AtrRと相互作用するHsp70ファミリータンパク質SsaAの機能解析

大場歩, 田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2012年度大会　2012/03
麹菌の CreA および HECT ユビキチンリガーゼ HulA 条件的発現株を用いたグルコース抑制機構の解析

田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2012年度大会　2012/03
変異型loxP配列を用いた麹菌における多重遺伝子導入法の確立

江原直樹, 水谷治, 新谷尚弘, 五味勝也

日本農芸化学会2012年度大会　2012/03
薬剤排出 ABC トランスポーターを制御する転写因子 AtrR と相互作用する因子の探索

大場歩, 田中瑞己, 新谷尚弘, 五味勝也

第11回糸状菌分子生物学コンファレンス　2011/11
麹菌由来新規 β‐グルコシダーゼに特徴的な基質特異性

工藤佳那子, 氏家成隆, 渡部昭, 新谷尚弘, 五味勝也

第11回糸状菌分子生物学コンファレンス　2011/11
麹菌マルトースパーミアーゼの各種炭素源による細胞内局在変化

平本哲也, 大道口涼子, 田中瑞己, 新谷尚弘, 五味勝也

第11回糸状菌分子生物学コンファレンス　2011/11
Cre-loxP システムを用いた麹菌における多重遺伝子導入システムの開発

江原直樹, 水谷治, 新谷尚弘, 五味勝也

第11回糸状菌分子生物学コンファレンス　2011/11
麹菌における HECT ユビキチンリガーゼ (hulA) 条件的発現株の作成

田中瑞己, 新谷尚弘, 五味勝也

第11回糸状菌分子生物学コンファレンス　2011/11
麹菌における異種遺伝子由来の転写産物の安定性解析

田中瑞己, 徳岡昌文, 新谷尚弘, 五味勝也

第146回日本農芸化学会東北支部大会　2011/10
Azole drug species-dependent responses of the transcription factor AtrR in Aspergillus oryzae. International-presentation

Ayumi Ohba, Takahiro Shintani, Katsuya Gomi

IUMS2011 XIII International. Congress of Bacteriology and Applied Microbiology　2011/09/06
麹菌のマルトースパーミアーゼのエンドサイトーシスに及ぼす各種炭素源の影響

平本哲也, 大道口涼子, 田中瑞己, 新谷尚弘, 五味勝也

第63回日本生物工学会大会　2011/09
出芽酵母モノカルボン酸輸送体 Jen1 のグルコース誘導的分解に関わる研究

松本耕助, 藤田聡美, 葛西寛一, 大橋優隆, 机伸太郎, 高木博史, 五味勝也, 新谷尚弘

酵母遺伝学研究会フォーラム第44回研究報告会　2011/09
Azole drug species-dependent responses of the transcription factor AtrR in Aspergilli. International-presentation

Ayumi Ohba, Kiminori Shimizu, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

26th Fungal Genetics Conferences　2011/03/15
Expressions of genes for fatty acid metabolism and peroxisomal biogenesis and the hydrophobin production in the farA disruptants of A. oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

26th Fungal Genetics Conferences　2011/03/15
Maltose permease-encoding mRNA is cleaved in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

26th Fungal Genetics Conferences　2011/03/15
Involvement of FarA transcription factor in fatty acid utilization in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

8th International Aspergillus Meeting (Asperfest8)　2011/03/14
Azole drug species-dependent responses of the transcription factor AtrR in Aspergilli. International-presentation

Ayumi Ohba, Kiminori Shimizu, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

8th International Aspergillus Meeting (Asperfest8)　2011/03/14
Maltose permease-encoding mRNA is cleaved in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

8th International Aspergillus Meeting (Asperfest8)　2011/03/14
特徴的な基質特異性を持つ麹菌由来新規β-グルコシダーゼの酵素学的諸性質

工藤佳那子, 氏家盛隆, 渡部昭, 新谷尚弘, 五味勝也

日本農芸化学会2011年度大会　2011/03
麹菌 Ski 複合体欠損株のデンプン/マルトース培地における生育抑制機構の解析

田中瑞己, 新谷尚弘, 五味勝也

日本農芸化学会2011年度大会　2011/03
麹菌のアゾール系薬剤耐性に関与する転写因子AtrRの薬剤の種類依存的応答

大場歩, 新谷尚弘, 五味勝也

日本農芸化学会2011年度大会　2011/03
出芽酵母アスパルチルアミノペプチダーゼApe4は選択的オートファジー経路依存的に液胞へ局在化する

柚賀正樹, 五味勝也, 新谷尚弘

日本農芸化学会2011年度大会　2011/03
変異型カルボキシペプチダーゼYの小胞体シャペロンとの相互作用と小胞体エクスポートの関係

堀瑞枝, 須山研吾, 五味勝也, 新谷尚弘

日本農芸化学会2011年度大会　2011/03
グルコースによって誘導される酵母モノカルボン酸輸送体Jen1の分解に関する研究

葛西寛一, 松本耕助, 大橋優隆, 机伸太郎, 五味勝也, 新谷尚弘

日本農芸化学会2011年度大会　2011/03
酵母に学ぶ選択的オートファジーのメカニズム

新谷尚弘

第52回日本植物生理学会年会　2011/03
酵母 cytoplasm to vacuole targeting (Cvt)経路の新しい輸送基質

第６回オートファジー研究会　2011/01/12
麹菌の転写制御因子 AtrR はアゾール系薬剤により活性化する

大場歩, 新谷尚弘, 五味勝也

第10回糸状菌分子生物学コンファレンス　2010/11
Expressions of genes for fatty acid metabolism and peroxisomal biogenesis and the hydrophobin production in the farA disruptants of A. oryzae.

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

第10回糸状菌分子生物学コンファレンス　2010/11
麹菌 α-1,3 グルカン合成遺伝子 agsB 破壊による細胞壁の分泌タカアミラーゼ吸着能への影響

佐藤宏樹, 新谷尚弘, 五味勝也

第10回糸状菌分子生物学コンファレンス　2010/11
麹菌の新規 ß – グルコシダーゼ (BglA, BglF) の精製と酵素学的諸性質

工藤佳那子, 氏家成隆, 渡辺昭, 新谷尚弘, 五味勝也

第10回糸状菌分子生物学コンファレンス　2010/11
麹菌マルトースパーミアーゼ mRNA は Ire1 ヌクレアーゼにより切断される

田中瑞己, 新谷尚弘, 五味勝也

第10回糸状菌分子生物学コンファレンス　2010/11
麹菌α-1,3 グルカン合成酵素遺伝子破壊による細胞壁の分泌タカアミラーゼ吸着能

佐藤宏樹, 新谷尚弘, 五味勝也

第62回日本生物工学会大会　2010/10
出芽酵母モノカルボン酸輸送体Jen1の変異体の分解様式

佐藤大地, 五味勝也

日本農芸化学会東北支部・北海道支部合同支部大会　2010/09/27
麹菌Aspergillus oryzae由来キシロース異性化システムの出芽酵母での発現

金田実郎, 五味勝也

日本農芸化学会東北支部・北海道支部合同支部大会　2010/09/27
アスパルチルアミノペプチダーゼApe4はCvt経路によって液胞へ輸送される

柚賀正樹, 五味勝也

酵母遺伝学フォーラム第43回研究報告会　2010/09/09
出芽酵母の変異型モノカルボン酸輸送体Jen1の分解様式

佐藤大地, 机伸太郎, 大橋優隆, 葛西寛一, 五味勝也

酵母遺伝学フォーラム　2010/09/09
麹菌Aspergillus oryzae の転写制御因子AoatrR のアゾール系薬剤による活性化

大場歩, 新谷尚弘, 五味勝也

日本農芸化学会東北支部・北海道支部合同支部大会（第145回東北支部大会）　2010/09
Functional analysis of FarA transcriptional factor in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

9th International Mycological Congress (IMC9)　2010/08/01
Functional characterization of the gene clusters for maltose utilization in Aspergillus oryzae. International-presentation

Sachiko Hasegawa-Shiro, Teiko Ebata, Takahiro Shintani, Katsuya Gomi

9th International Mycological Congress (IMC9)　2010/08/01
Up-regulation of ABC transporter genes stimulated by azole drugs dependent on the transcription activator AtrR in Aspergillus oryzae. International-presentation

Ayumi Ohba, Takahiro Shintani, Katsuya Gomi

10th European Conference on Fungal Genetics (ECFG10)　2010/03/29
Deciphering the function of FarA transcriptional factor in the expression of lipolytic genes and production of enzymes for the degradation of biodegradable plastics in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

10th European Conference on Fungal Genetics (ECFG10)　2010/03/29
Identification of cell wall factor(s) adsorbing Taka-amylase in submerged culture of Aspergillus oryzae. International-presentation

Hiroki Sato, Takahiro Shintani, Katsuya Gomi

10th European Conference on Fungal Genetics (ECFG10)　2010/03/29

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Prize-winning poster
Essentiality of RNA exosome subunit encoding genes in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

10th European Conference on Fungal Genetics (ECFG10)　2010/03/29
Identification of Cell Wall Factor(s) Adsorbing Taka-amylase in Submerged Culture of Aspergillus oryzae. International-presentation

Hiroki Sato, Takahiro Shintani, Katsuya Gomi

7th International Aspergillus Meeting (Asperfest7)　2010/03/28
Essentiality of RNA exosome subunit encoding genes in Aspergillus oryzae. International-presentation

Mizuki Tanaka, Takahiro Shintani, Katsuya Gomi

7th International Aspergillus Meeting (Asperfest7)　2010/03/28
Implication of FarA transcriptional factor in the expression of lipolytic genes in Aspergillus oryzae. International-presentation

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katsuya Gomi

7th International Aspergillus Meeting (Asperfest7)　2010/03/28
The transcription activator AtrR regulates gene expression of ABC transporters and contributes to azole drug resistance in Aspergillus fumigatus. International-presentation

Ayumi Ohba, Kiminori Shimizu, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

7th International Aspergillus Meeting (Asperfest7)　2010/03/28
出芽酵母アスパルチルアミノペプチダーゼは選択的オートファジーによって液胞へ輸送される

柚賀正樹, 五味勝也

日本農芸化学会2010年度大会　2010/03/27
麹菌由来の新規β‐グルコシダーゼ(BglA)の精製と酵素学的諸性質

工藤佳那子, 氏家成隆, 渡部昭, 新谷尚弘, 五味勝也

日本農芸化学会2010年度大会　2010/03
麹菌の解糖系酵素遺伝子の選択的転写開始機構の解析

高間充, 香曽我部恵子, 戸田智美, 町田雅之, 新谷尚弘, 五味勝也

日本農芸化学会2010年度大会　2010/03
多様な熱力学的安定性を持つ変異型カルボキシペプチダーゼY(CPY)シリーズを用いたタンパク質品質管理機構の解析

堀瑞枝, 須山研吾, 五味勝也

第32回日本分子生物学会年会　2009/12/09
Construction of the disruptants for exosome subunit encoding genes in Aspergillus oryzae.

田中瑞己, 新谷尚弘, 五味勝也

第32回日本分子生物学会年会　2009/12
麹菌のタンパク質品質管理機構における hyperglycosylation の役割

小野崎保道, 城大介, 横田淳一, 五味勝也, 新谷尚弘

第9回糸状菌分子生物学コンファレンス　2009/11

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学生ポスター賞受賞
麹菌におけるエキソソーム構成サブユニット遺伝子破壊株の造成

田中瑞己, 新谷尚弘, 五味勝也

第9回糸状菌分子生物学コンファレンス　2009/11
麹菌の液体培養初期におけるタカアミラーゼ吸着阻害因子の探索

佐藤宏樹, 新谷尚弘, 五味勝也

第9回糸状菌分子生物学コンファレンス　2009/11
麹菌 atrR 高発現株及び atrR 破壊株のトランスクリプトーム解析

大場歩, 新谷尚弘, 五味勝也

第9回糸状菌分子生物学コンファレンス　2009/11
麹菌の解糖系酵素遺伝子の選択的転写開始機構の開始

高間充, 香曽我部恵子, 戸田智美, 町田雅之, 新谷尚弘, 五味勝也

第9回糸状菌分子生物学コンファレンス　2009/11
Functional analysis of FarA transcriptional factor in Aspergillus oryzae.

Sharon Marie Garrido, Noriyuki Kitamoto, Akira Watanabe, Takahiro Shintani, Katuya Gomi

第9回糸状菌分子生物学コンファレンス　2009/11
麹菌タカアミラーゼの細胞壁吸着における可溶性多糖の影響

佐藤宏樹, 新谷尚弘, 五味勝也

第144回日本農芸化学会東北支部大会　2009/10
分泌タンパク質の小胞体からのエクスポートと小胞体関連分解は競合する

須山研吾, 堀瑞枝, 五味勝也

酵母遺伝学フォーラム第42回研究報告会　2009/07/28
小胞体関連分解をバイパスした異常分泌タンパク質の液胞での分解

須山研吾, 五味勝也

酵母遺伝学フォーラム　2009/07/28
The transcription activator AtrR is involved in azole drug resistance by regulating the expression of ABC transporter genes in Aspergillus fumigatus. International-presentation

Ayumi Ohba, Kiminori Shimizu, Takahiro Shintani, Susumu Kawamoto, Katsuya Gomi

17th Congress of the International Society for Human and Animal Mycology (ISHAM2009)　2009/05/25
Identification of putative polyadenylation signals in Aspergillus oryzae using EST data. International-presentation

25th Fungal Genetics Conferences　2009/03/17
Identification of putative polyadenylation signals in Aspergillus oryzae using EST data. International-presentation

Mizuki Tanaka, Yoshifumi Sakai, Osamu Yamada, Takahiro Shintani, Katsuya Gomi

6th International Aspergillus Meeting (Asperfest6)　2009/03/15
キシロース資化性酵母の分子育種

日本農芸化学会2009年度大会　2009/03
麹菌細胞壁の分泌タカアミラーゼ吸着因子の同定

佐藤宏樹, 新谷尚弘, 五味勝也

日本農芸化学会2009年度大会　2009/03
麹菌の薬剤排出 ABC トランスポーター遺伝子の発現を制御する転写因子 AtrR のシスエレメント解析

大場歩, 三浦大介, 新谷尚弘, 五味勝也

日本農芸化学会2009年度大会　2009/03
麹菌 MAL cluster 遺伝子のプロモーター領域の解析

長谷川祥子, 新谷尚弘, 五味勝也

日本農芸化学会2009年度大会　2009/03
麹菌のセルロース系バイオマス分解関連酵素の網羅的な発現

氏家成隆, 渡辺昭, 新谷尚弘, 五味勝也

日本農芸化学会2009年度大会　2009/03
EST 配列データを用いた麹菌 (Aspergillus oryzae) における 3’-end processing signal 及び 3’-UTR 配列の解析

田中瑞己, 酒井義文, 山田修, 新谷尚弘, 五味勝也

第3回日本ゲノム微生物学会年会　2009/03
異常分泌タンパク質の小胞体関連分解(ERAD)と輸送小胞への取込みは競合している

須山研吾, 五味勝也

３１回日本分子生物学会　2008/12
EST 配列データを利用した糸状菌における poly(A) 付加シグナルの解析

田中瑞己, 酒井義文, 山田修, 新谷尚弘, 五味勝也

第31回日本分子生物学会年会　2008/12
酵母を宿主とした麹菌のセルロース分解酵素発現ライブラリーの作製

大橋優隆, 五味勝也

第60回日本生物工学会大会　2008/08/27
麹菌の転写因子PrtRのプロテアーゼ及び異種タンパク質生産への関与

小野崎保道, 松浦知巳, 新谷尚弘, 五味勝也

第60回日本生物工学会大会　2008/08
麹菌における新規エンドグルカナーゼの精製と特性解析

氏家成隆, 大橋優隆, 渡辺昭, 新谷尚弘, 五味勝也

第60回日本生物工学会大会　2008/08
A luminal misfolded protein retaining the endoplasmic reticulum exit signal bypasses the ER-associated degradation and is sorted ti the vacuole for degradation by the vacuolar sorting receptor Vps10 International-presentation

Kengo Suyama, Masaki Yuga, Katsuya Gomi, Takahiro Shintani

2008 Yeast genetics and molecular biology meeting　2008/07/22
Cellular responses to the expression of aberrant secretory proteins in Aspergillus oryzae International-presentation Invited

9th European Conference on Fungal Genetics　2008/04/05
Cellular responses to the expression of an aberrant secretory protein in Aspergillus oryzae International-presentation Invited

5th International Aspergillus Meeting (Asperfest)　2008/04/04
酵母輸送レセプターVps10による異常分泌タンパク質の認識機構の解析

柚賀正樹, 須山研吾, 五味勝也

日本農芸化学会2008年度大会　2008/03/26
出芽酵母における小胞体関連タンパク質分解の回避機構の解析

須山研吾, 五味勝也

日本農芸化学会2008年度大会　2008/03
麹菌の液体培養における分泌タカアミラーゼの細胞壁吸着因子の探索

佐藤宏樹, 豊島快幸, 新谷尚弘, 五味勝也

日本農芸化学会2008年度大会　2008/03
麹菌 A. oryzae の MAL クラスターはアミラーゼの初期誘導生産に関与する

長谷川祥子, 新谷尚弘, 五味勝也

日本農芸化学会2008年度大会　2008/03
麹菌の GlaB 高発現に関与する転写因子遺伝子

工藤洋平, 寺田りつ子, 新谷尚弘, 五味勝也

日本農芸化学会2008年度大会　2008/03
出芽酵母における異常分泌タンパク質の液胞への選別輸送の解析

須山研吾, 五味勝也

第30回日本分子生物学会年会・第80回日本生化学会大会　2007/12
出芽酵母における異常分泌タンパク質の液胞への選別輸送の解析

須山研吾, 五味勝也

日本農芸化学会2007年度大会　2007/03
オートファジーに必須な新規のタンパク質結合酵素Apg10の解析

水島昇, 野田健司, 大隅良典

日本生化学会７２回大会　1999/10
オートファジーに必須なタンパク質結合酵素Apg10p

水島昇, 野田健司, 大隅良典

酵母遺伝学フォーラム第３２回研究報告会　1999/07
Apg10p, a novel protein-conjugation enzyme essential for autophagy International-presentation

Noboru Mizushima, Takeshi Noda, Yoshinori Ohsumi

6th CGGH Symposium "Biological Role of Proteolysis in Health and Disease"　1999/05/19
蛋白質工学的手法によるブタ・ペプシンの基質特異性の変換

野村耕司, 一島英治

日本生化学会６９回大会　1996/08
アスペルギロペプシンIのSer-78の役割

一島英治

日本農芸化学会1995年度大会　1995/08
Aspergillopepsin IのAsp-76の役割

小林瑞枝, 野谷靖啓, 一島英治

日本生化学会６７回大会　1994/09
アスペルジロペプシンIのトリプシノーゲン活性化機構

小林瑞枝, 山形洋平, 一島英治

日本農芸化学会1994年度大会　1994/04
Aspergillus saitoiのaspergillopepsin I cDNAのクローニング

Takahiro Shintani, Eiji Ichishima

日本農芸化学会1993年度大会　1993/04
Aspergillus saitoi酸性プロテアーゼ遺伝子のクローニング

一島英治

日本生化学会第６５回大会　1992/10

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Research Projects 26

膜輸送体分解のメカニズム・生物学的意義の解明と物質生産への応用

新谷尚弘, 藤田翔貴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2024/04/01 - 2028/03/31
酵母の呼吸代謝から発酵への転換におけるグルコース不活性化の総合理解

新谷尚弘, 藤田翔貴

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2020/04/01 - 2024/03/31

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酵母Saccharomyces cerevisiaeでは、グルコースなどの発酵性炭素源があると、酸素が存在していてもエタノール発酵が優先的に起こり、呼吸代謝は抑制される。グルコースが枯渇すると、転写因子Cat8支配下にある糖新生関連遺伝子群の転写が一気に活性化される。しかし、環境中に再びグルコースが流入してくると、これら遺伝子群の転写が抑制されると共に、それらの翻訳産物が分解（グルコース不活性化）される例が報告されている。Cat8支配下で発現する遺伝子産物のグルコース不活性化を網羅的に観察したところ（ただし、既にグルコース不活性化を受けることが知られているFbp1、Mdh2、Icl1、Pck1は除いた）、グリセロール輸送体Stl1、酢酸輸送体Ady2、転写因子Sip4のグルコース依存的な分解が観察された。また、Cat8自身もグルコースに応答して分解されることが明らかとなった。Stl1は乳酸・ピルビン酸輸送体Jen1と同様にRsp5-Rod1ユビキチンリガーゼ複合体によってC末端領域に存在するリシン残基がユビキチン化され、エンドサイトーシスされることが明らかとなった。Cat8のグルコース不活性化はプロテアソーム阻害剤によって抑制されたことから、ユビキチンープロテアソーム系が関わっていることが示唆された。糖新生経路の鍵転写因子であるCat8タンパク質の量が、転写レベルに加え翻訳後レベルでも厳密に制御されていることが示唆された。
Analysis of immunological properties of mannose-based molecules and its action mechanisms.

Toda Masako

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2019/04/01 - 2022/03/31

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The aim of this study was to identify immunological function of mannose-based molecules and its action mechanisms. Among α-mannooligosaccharides, long chain molecules such as α-Man-(1→6)-Man4 inhibited lipopolysaccharide (LPS)-stimulated activation of bone marrow derived murine dendritic cells (BMDC). In contrast, among β-mannooligosaccharides, β-Man-(1→4)-Man activated BMDC via engagement of toll-like receptor 4. We also found that α-mannan from yeast promotes anti-inflammatory responses (e.g., IL-10 production) in BMDC when it was stimulated with LPS. Metabolome analysis showed that α-mannan altered levels of many metabolites in BMDC, e.g., an increased level of lactic acid, the final product of glycolysis, and a reduced level of succinic acid, an inflammatory metabolite of TCA cycle. The results suggest that α-mannan induces reprogram of cellular metabolism and thereby promotes anti-inflammatory response in BMDC.
機能性アミノ酸高含有酵母の育種技術を活用した発酵・醸造食品の高付加価値化および海外ブランド化

新谷尚弘

Offer Organization: 国立研究開発法人農業・食品産業技術総合研究機構生物系特定産業技術支援センター

System: イノベーション創出強化研究推進事業

Institution: 奈良先端科学技術大学院大学

2020/04 - 2021/03
機能性アミノ酸高含有酵母の育種技術を活用した発酵・醸造食品の高付加価値化および海外ブランド化

Offer Organization: 国立研究開発法人農業・食品産業技術総合研究機構生物系特定産業技術支援センター

System: イノベーション創出強化研究推進事業

Institution: 奈良先端科学技術大学院大学

2019/04 - 2020/03
糸状菌に特有の小胞体ストレス下における分泌タンパク質mRNAの減少

Offer Organization: 公益財団法人野田産業科学研究所

System: 野田産研研究助成

2019/04 - 2020/03
酵母オートファゴソーム形成に必要な小胞輸送関連因子の同定とその役割 Competitive

新谷尚弘

System: 科学研究費補助金

2017/04 - 2020/03
Characterization of intramembrane proteases by the yeast resonctitution system

Eugene Futai, Shintani Takahiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2016/04 - 2019/03

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γ-secretase generates amyloid β peptide (Aβ) from amyloid precursor protein (APP) through multi step cleavage, such as endoproteolysis and trimming. In the study, we reconstituted human γ-secretase complex and APP in yeast and identified activating mutations in the catalytic subunit of γ-secretase presenilin 1 (PS1), and the regulatory subunit Aph1aL. We introduced these mutants in yeast and mammalian cells and found that the mutations increase the stepwise cleavage activity (cleavage and trimming), and in particular, decrease long-chain Aβ42 by raising trimming. We also clarified the conformational changes of each subunit with activation. It has become an important finding in the development of antidementia drugs that reduce the production of highly toxic Aβ42 involved in the onset of dementia.
Molecular mechanisms for modification of carbon catabolite repressors and sugar transporters in filamentous fungi

GOMI KATSUYA, SHINTANI TAKAHIRO, TANAKA MIZUKI, ICHINOSE SAKURAKO, MATSUURA YUKA, TADA HINAKO

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2013/04/01 - 2017/03/31

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The abundance of the carbon catabolite repressor CreA was reduced after incubation in the maltose and xylose media that induce amylase and xylanase gene expression in A. oryzae. Subcellular localization analysis suggested that maltose and xylose stimulated export of CreA from the nucleus to the cytoplasm and mutation of a putative nuclear export signal resulted in nuclear retention and significant stabilization of CreA. CreA protein level was reduced by disruption of creB and creC, both of which encode the deubiquitinating enzyme complex, but not affected by disruption of creD encoding an arrestin-like protein. CreD was involved in glucose-induced endocytosis of maltose permease and carbon catabolite de-repression of amylase gene expression in A. oryzae. Dephosphorylation of CreD was required for carbon catabolite de-repression triggered by the disruption of creB; a combination of the phosphorylation-defective mutation of CreD and creB disruption improved amylolytic enzyme production.
出芽酵母のリン酸飢餓応答におけるオートファジーの役割とその誘導機構に関する研究

Offer Organization: 公益財団法人発酵研究所

System: 平成27年度（2015年度）一般研究助成

2015/04 - 2017/03
酵母膜輸送体のグルコース不活性化の分子機構とその生物学的意義 Competitive

新谷尚弘

System: 科学研究費補助金

2014/04 - 2017/03
Development of efficient gene expression systems for secondary metabolite production in filamentous fungi

GOMI Katsuya, MACHIDA Masayuki, SHINTANI Takahiro, KOIKE Hideaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tohoku University

2010/04/01 - 2015/03/31

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We developed a self-excising Cre/loxP-mediated marker recycling system with mutated lox sequences to introduce a number of biosynthetic genes into Aspergillus oryzae. By using the marker recycling system constructed, hyperproduction of kojic acid could be achieved in A. oryzae by the introduction of the two genes that each encodes oxidoreductase and transporter. Deletion of the transporter resulted in a significant decrease in the yield of kojic acid compared to the wild type strain, indicating that overexpression of the transporter gene is highly effective in improving the production yield of secondary metabolites. In addition, expression vectors with multiple expression cassettes consisting of the amyB promoter and terminator were also constructed. We examined subcellular localization of the enzyme proteins encoded by a gene cluster involved in aphidicolin biosynthesis from Phoma betae, which were expressed as GFP-fusion proteins in A. oryzae.
Comprehensive analyses of regulatory mechanisms associated with hydrolytic enzyme production and metabolic pathway involved in biomass degradation in filamentous fungi

GOMI Katsuya, KOBAYASHI Tetsuo, SHINTANI Takahiro, KATO Masashi

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2010/04/01 - 2013/03/31

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(1) Transcription factor AmyR was localized to nucleus and significantly unstable in the presence of inducer, but MalR showed constitutive nuclear localization and stability irrespective of carbon sources. AmyR was associated with chaperons Hsp70 and Hsp90. (2) Maltose transporter MalP was targeted to the vacuole after addition of glucose. Both HECT ubiquitin ligase HulA and arrestin-like protein CreD are required for glucose-induced endocytosis of MalP. In addition, pull-down analysis using CreD-3FLAG and WW domains of HulA fused to GST indicated that CreD could interact with HulA via WW domains. (3) Comprehensive screening of genes involved in pentose metabolism was performed by transcriptome analysis, and enzymatic properties of candidate gene products were analyzed, which resulted in the complete elucidation of the pentose metabolic pathway in Aspergillus oryzae.
Roles of a vesicular transport network and a membrane fusion in autophagy in Saccharomyces cerevisiae Competitive

SHINTANI Takahiro, GOMI Katsuya

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2011/04 - 2013/03

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We found that autophagy was inhibited when the secretory pathway was blocked in several SNARE (soluble NSF attachment protein receptor) mutants, suggesting that a supply of membrane lipid from the secretory pathway might be important for autophagosome formation. We also showed that some SNARE proteins directly associated with Atg9, which plays roles in autophagosome formation, at preautophagosomal structure, suggesting that these proteins might function as machinery of autophagosome formation.
次世代バイオエタノール生産高発現の開発

新谷尚弘

Offer Organization: 独立行政法人科学技術振興機構

System: 戦略的創造研究推進事業平成23年度シーズ探索プログラム

2011/07 - 2012/03
オートファジー制御剤の大規模探索法の開発

Offer Organization: 公益財団法人アステラス病態代謝研究会

System: 東日本大震災緊急研究助成金

2011 - 2012
異常分泌タンパク質のERADエスケープとその相補的分解機構の解析 Competitive

System: Grant-in-Aid for Scientific Research

2008/04 - 2010/03
Development of the tailor-made enzymes for cellulose hydrolyzation used with microbial gene sources. Competitive

System: Grant-in-Aid for Promotion of Private Scientific Research

2007/04 - 2009/03
Molecular basis of a cellular response to the environment by lysosomal/vacuolar proteolysis. Competitive

SHINTANI Takahiro, GOMI Katsuya, OHASHI Shinichi

Offer Organization: Japan Society for the Promotion of Science

System: Grant-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2007/04 - 2009/03
Molecular mechanisms for production of useful proteins in Aspergillus fungi based on genomic information

GOMI Katsuya, ABE Keietsu, KOBAYASHI Tetsuo, KITAMOTO Katsuhiko, SHINTANI Takahiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research on Priority Areas

Institution: Tohoku University

2005 - 2009

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Based on genome database of koji-mold (Aspergillus oryzae), approximately 400 genes encoding transcription factor have been found, and a library for strains that express those factor genes at high level has been constructed. By using this library, several transcription factors involved in production of industrially important enzymes such as protease, cellulase, lipase, and so on, have been found. Comprehensive analyses of genes/proteins in signal transduction pathway have revealed the novel histidine kinase involved in anaerobic response and the first direct biochemical evidence for the existence of His-Asp phosphotransfer systems in filamentous fungi. In addition, yield of heterologous protein production has been improved by using protease-low-producer strains.
出芽酵母におけるcytoplasm to vacuole targeting (Cvt)経路の輸送基質の同定

新谷尚弘

Offer Organization: サッポロ生物科学財団

System: 平成19年度(第23回)研究助成

2007/10 - 2008/09
Ethanol production from cellulosic biomass by xylose-utilizing yeast. Competitive

System: Grant-in-Aid for Promotion of Private Scientific Research

2006/11 - 2007/10
Stabilization and secretion of heterologous proteins by means of intracellular trafficking technology. Competitive

System: Grant-in-Aid for Scientific Research

2005/04 - 2007/03
Cellular response to the overexpression of mutated or exogenous secretory proteins in Aspergillus oryzae Competitive

System: Grant-in-Aid for Promotion of Private Scientific Research

2005/04 - 2006/03
真核微生物の新規非翻訳型RNA「リボスイッチ」による遺伝子発現制御の分子機構

五味勝也, 新谷尚弘

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 萌芽研究

Institution: 東北大学

2005 - 2006

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前年に引き続き、偽遺伝子と予想されたtpnAの5'非翻訳領域(5'UTR)のイントロン内に存在するチアミンリボスイッチ様配列の機能を検証するため、nmtAプロモーターの下流にtpnAの5'UTRおよびGUS遺伝子を連結し、ノーザン解析及びGUS発現解析を行ったところ、GUS活性はチアミン制御を受けていたが、転写はチアミンの有無にかかわらず同程度のレベルであった。一方、転写産物のRT-PCR解析によりチアミン存在下でもリボスイッチ様配列を含む介在配列はイントロンとしてスプライシングされていた。このことは、転写と翻訳とが独立に制御されていることを示唆しており、今後の検討が必要と考えられた。またEST解析の結果、tpnAはゲノム解析により上流に存在すると考えられる遺伝子を含んだmRNAとして転写されていることが認められたことから、真核生物ではまれなポリシストロン構造をとっている可能性が示唆された。そこで、他のAspergillus属カビのゲノム情報と比較することによって上流の遺伝子の妥当性も含めて構造を解析したが、他のカビには遺伝子に相当する配列は見出されず、i麹菌においてのみこの遺伝子が存在することが示された。興味深いことに、上流の遺伝子からの転写産物ではリボスイッチ様配列を含む介在配列はイントロンとしてスプライシングされておらず、3'UTR領域に存在するリボスイッチは機能しないことが考えられた。このことは、すでに明らかにしているように、3'UTRにリボスイッチが存在してもチアミン抑制は起こらず、5'UTRまたはN末に近いコード領域にリボスイッチを内在したイントロンが存在することがチアミン制御に必要であることと一致する。
自食作用における栄養飢餓シグナル伝達機構の解析

新谷尚弘

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 特別研究員奨励費

Institution: 岡崎国立共同研究機構

1998 - 2000

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Social Activities 3

令和6年度高大連携事業に係る地域公開講座

2024/07/25 - 2024/07/25
東京都立小松川高校出前授業

2023/10/04 -
宮城県仙台第三高等学校進路講演会

2016/05/27 -

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東北大学農学部の概要説明、本人の研究紹介、入試説明

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出芽酵母のリン酸飢餓応答におけるオートファジーの役割とその誘導機構に関する研究

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出芽酵母のリン酸飢餓応答におけるオートファジーの役割とその誘導機構に関する研究
酵母アッセイ系を用いたアミロイドβ毒性ターゲットの網羅的解析と認知症治療薬の大規模スクリーニング

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アミロイドβ産生系を酵母細胞で再構成し、この再構成系を用いたアミロイドβの毒性ターゲットとなる分子の同定や低分子化合物ライブラリーからのアミロイドβ生成阻害剤やアミロイドβ毒性を軽減する化合物の単離を行う。
次世代型バイオエタノール生産酵母株の開発

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グルコースが培養環境中に存在すると他の炭素源は消費されず、グルコースが優先的に利用される。このグルコース効果と呼ばれる現象は様々な炭素源を含むバイオマス原料を並行発酵する技術の開発にとって障害となる。現在、グルコース効果はカタボライト抑制と呼ばれる遺伝子発現制御で説明されているが、その翻訳産物(タンパク質)がグルコースに応答して速やかに分解されるカタボライト不活性化と協調して起こることが知られている。このことは、仮にグルコースと競合する炭素源を利用できるように遺伝子発現を制御できたとしても、グルコースが存在している限りその遺伝子産物は分解され続けることを意味している。このような観点から、カタボライト不活性化の制御が重要であることは想像に難くないが、その詳細な機構は不明である。バイオエタノールの原料として期待される農産廃棄物にはグルコースに次いで多くのキシロースが構成糖として含まれているが、出芽酵母はキシロースを利用できない。申請者はすでにキシロースを資化できる組換え酵母の作出に成功しているが、グルコース存在下でのキシロース資化は抑制されていた。グルコースによるキシロース代謝経路の不活性化がその原因だと考えられる。本研究では、キシロース代謝経路(トランスポーターおよび代謝酵素群)のグルコース不活性化機構について解析し、バイオマス並行発酵を可能とする出芽酵母の作出を試みる。
出芽酵母におけるcytoplasm to vacuole targeting (Cvt)経路の輸送基質の同定

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真菌や植物細胞の液胞は動物細胞のリソソームに相当するオルガネラであり、プロテアーゼやリボヌクレアーゼ、ポリリン酸分解酵素などの様々な加水分解酵素を含んでいる。このオルガネラは環境条件やストレスに応答して、タンパク質や脂質、核酸などの様々な高分子化合物を分解することにより細胞の構成成分を最適化しており、細胞の恒常性維持に重要な役割を果たしている。また、リソソームとは異なり液胞は二価イオンやアミノ酸などの低分子化合物やポリリン酸の貯蔵コンパートメントとしての機能も合わせ持つ。外界の栄養源が不足した場合には、これらの貯蔵物質が利用されるとともに、オートファジーと呼ばれる機構により自らの細胞質成分を非選択的に液胞に送り込んで分解することにより、飢餓条件下を生存するための最低限の栄養源を確保している。オートファジーの過程は①飢餓シグナルの伝達、②二重膜構造体による細胞質成分の囲い込み、③二重膜小胞と液胞膜との融合、 ④内膜小胞の液胞ルーメンへの放出と分解の４つに大別され、生体膜のダイナミックな動態を伴う。一方で、これら高分子基質を分解するための加水分解酵素群は主に初期分泌経路（小胞体、ゴルジ体）を経て液胞に輸送されるが、興味深いことにある種の液胞酵素は分泌経路を経ることなく直接細胞質から液胞へと輸送されることが出芽酵母において報告されている。この経路はcytoplasm to vacuole targeting (Cvt) 経路と呼ばれ、オートファジーとトポロジー的に類似した小胞輸送を伴う。また、遺伝学的にもオートファジーとCvt経路に必要な遺伝子の大半が重複していることが明らかとされており、Cvt経路はオートファジーの一形態だと考えられる。両経路の主たる相違点は誘導条件と積み荷の選択性の有無である。一般的にオートファジーが飢餓条件下で誘導される非選択的な分解機構であるのに対し、Cvt経路は選択的な液胞タンパク質の生合成経路である。現在までにCvt経路で輸送されるタンパク質としてアミノペプチダーゼI およびα-マンノシダーゼが報告されている。いずれもAtg19と呼ばれるレセプタータンパク質によって認識されることにより、選択的に液胞へ輸送される。Atg19によって認識される加水分解酵素が他に存在しているかどうかは検討すべき点である。そこで、当該研究ではCvt経路で輸送される新規の液胞タンパク質を同定し、その機能を明らかにする。さらにこれらタンパク質の外界栄養条件の変化に伴う発現や局在の変化を解析することにより、液胞における生体高分子の分解・代謝におけるCvt経路の役割を解明することを目的とする。
微生物遺伝子資源を利用したテーラーメイドセルロース糖化酵素の開発

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石油燃料の枯渇、二酸化炭素排出量の削減のために再生可能な植物由来のバイオマスからの燃料生産技術が求められている。現在市場に出ているバイオエタノールの生産には加工が簡単な糖類やデンプンが利用されているが、それらは穀物由来であるため食料との競合が起こっている。そこで、農産物の非食部である藁や籾殻などの木質バイオマスを利用し、エタノールの生産を行うことが求められている。そのためには木質バイオマスの主要成分であるセルロースを効率よく糖化する酵素が必要である。当研究ではゲノム解析が行われた麹菌の遺伝子資源を用い、未知のセルロース糖化酵素の探索を行う。
木質系バイオマスを発酵原料としたエタノール生産ーキシロース資化酵母の育種と木質系バイオマス分解酵素の探索ー

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現在エタノール生産に産業的に用いられている酵母はキシロースを資化出来ない。そこで、キシロースを資化出来る酵母を分子遺伝学的手法により育種する。また、この株を用いてキシロースからなる高分子ポリマーであるキシラン分解酵素を麹菌ゲノムから探索する。
木質系バイオマス成分を発酵原料としたエタノールおよび乳酸の生産

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京都議定書の発効に伴い、日本は二酸化炭素の排出量削減への対応を迫られている。石油の代替物として再生可能なバイオマスの利用が求められているが、国土面積が小さく人口密度が高い我が国では大規模なエネルギー作物の栽培は不可能であるため、廃棄物あるいは未利用バイオマスのエネルギーや化学原料への変換が注目されている。我が国では年間1,300万トンの稲わら、籾殻などの農作物非食用部が発生し、その約70％が未利用バイオマスとして廃棄されている。現在、代替エネルギーとしてのバイオエタノールの生産は、酵母を用いた発酵生産が主力である。トウモロコシやサトウキビなどの資源作物が良質な発酵原料であるデンプンや糖類を主成分としている（トウモロコシの成分中70％がデンプン）のに対し、稲わら、籾殻などの木質系バイオマスはセルロース（45％）、ヘミセルロース（30％）を主成分としている。セルロースは酵母による発酵が可能なグルコースに変換できるが、ヘミセルロースの主構成糖であるキシロースは酵母では発酵できないため、木質系バイオマスはデンプンなどを主成分とする糖質系バイオマスに対して競争力を持っていない。酵母Saccharomyces cerevisiaeはキシロース代謝の第一段階であるキシロース異性化反応を触媒するキシロースイソメラーゼを欠いているため、キシロースを資化する事ができない。そこで、キシロースイソメラーゼ遺伝子を有する種々の細菌や植物から遺伝子を単離し、それぞれを酵母に導入することにより、キシロースをエタノールへ変換できる酵母の育種を行う。また、現在当研究室にて乳酸発酵を高効率で行う酵母の分子育種を行っており、さらにキシロース資化経路を組み込むことにより、キシロースから生分解性プラスチックの原料である乳酸へ変換可能な酵母の分子育種も行う。
変異または異種分泌タンパク質の過剰発現に対する麹菌の細胞応答

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麹菌は我が国の発酵産業を支える主要な産業微生物である。そのタンパク質分泌能の高さから、異種タンパク質の分泌発現の宿主としての利用が期待されている。異種タンパク質発現による分泌ストレスに対する麹菌の細胞応答を解析する。

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