Details of the Researcher

PHOTO

Kazuki Watanabe
Section
Institute of Development, Aging and Cancer
Job title
Assistant Professor
Degree
e-Rad No.
10908073

Research History 6

  • 2024/04 - Present
    Tohoku University

  • 2022/04 - 2024/03
    KOMATSU UNIVERSITY

  • 2021/05 - 2024/03
    Tokyo Medical and Dental University　College of Liberal Arts and Sciences Natural Sciences Biology　Visiting Lecturer

  • 2021/04 - 2022/03
    Tokyo Medical and Dental University　College of Liberal Arts and Sciences Natural Sciences Biology

  • 2020/04 - 2021/03
    Tokyo Medical and Dental University　Graduate School of Medical and Dental Sciences

  • 2017/04 - 2021/03
    Tokyo Medical and Dental University　Graduate School of Medical and Dental Sciences　Graduate Student

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Education 2

  • 東京医科歯科大学 大学院　医歯学総合研究科 博士課程

    2017/04 - 2021/03

  • Tokyo Medical and Dental University　Faculty of Dentistry

    2009/04 - 2015/03

Professional Memberships 5

  • 日本認知症学会

  • 日本比較内分泌学会

  • 日本歯科保存学会

  • 日本抗加齢医学会

  • 日本歯周病学会

Research Interests 4

  • 抗加齢医学

  • 分子内分泌学

  • 歯周医学

  • メラトニン

Research Areas 2

  • Life sciences / Molecular biology /

  • Life sciences / Molecular biology /

Awards 8

  1. 2024年度日本抗加齢医学会研究奨励賞（渡辺数基）

    2025/06　日本抗加齢医学会

  2. 2021年度若手研究賞（渡辺数基）

    2022/06　日本抗加齢医学会

  3. 2021年度若手研究者最優秀発表賞（渡辺数基）

    2021/11　日本比較内分泌学会

  4. 2020年度日本歯周病学会奨励賞（渡辺数基）

    2021/05　日本歯周病学会

  5. 博士課程総代(渡辺数基)

    2021/03　東京医科歯科大学大学院医歯学総合研究科

  6. 2020年度 日本歯周病学会Sunstar Young Investigator Award（渡辺数基）

    2020/10　日本歯周病学会　Porphyromonas gingivalisは腸内細菌叢を変化させ、骨格筋における糖取り込みを阻害する

  7. 2018年度日本歯周病学会教育賞

    2019/05　日本歯周病学会　東京医科歯科大学歯学部学生の歯周治療臨床実習の改革とその現状

  8. 第20回SCRP 日本代表選抜大会 入賞

    2015/08　日本歯科医師会

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Papers 34

  1. Melatonin suppresses the plasma calcium level in female goldfish during the late and post-reproductive stages. International-journal

    Yusuke Maruyama, Kazuki Watanabe, Risa Matsuoka, Kohei Kuroda, Hajime Matsubara, Nobuo Suzuki, Atsuhiko Hattori, Jun Hirayama

    Scientific reports　15　(1)　31480-31480　2025/08/26

    DOI： 10.1038/s41598-025-14026-8 　

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    In vertebrate females, plasma calcium concentrations decrease after the reproductive period to prevent calcium from leaking from the body. Goldfish scales store calcium internally, which is released into the blood by osteoclast resorption. Previously, we found that melatonin increases calcitonin (CT), an osteoclast inhibitor, through melatonin receptors in goldfish scales, and inhibits osteoclast activity. However, the physiological function of the melatonin-dependent suppression of osteoclast activity is unclear. In this study, we found that plasma calcium levels increased during the reproductive stage in female goldfish and decreased during the post-reproductive stage. Histological and mRNA expression analyses of osteoclast marker molecules revealed that osteoclasts in the scales were inactivated during the late and post-reproduction stages when the expression of CT and its receptor increased in female goldfish scales. Moreover, exogenous melatonin suppressed plasma calcium levels in female goldfish during their late reproductive stage in cases of increased melatonin receptor expression. Taken together, these results suggest that melatonin inactivates scale osteoclast resorption by increasing CT levels in the scales and prevents calcium leakage from the body during the late and post-reproductive stages of female goldfish.

  2. Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity Peer-reviewed

    Nobuo Suzuki, Kouhei Kuroda, Mika Ikegame, Harumi Takino, Keito Tsunoda, Riku Izumi, Yoshiaki Tabuchi, Yukihiro Furusawa, Koji Yachiguchi, Masato Endo, Hajime Matsubara, Sachiko Yano, Toru Shimazu, Masato Honda, Yusuke Maruyama, Kazuki Watanabe, Akihisa Takahashi, Jun Hirayama, Atsuhiko Hattori

    Life Sciences in Space Research　46　128-136　2025/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.lssr.2025.04.004 　

    ISSN： 2214-5524

  3. Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine, a melatonin metabolite, in the hippocampus: a potential prophylactic agent for dementia Invited Peer-reviewed

    Kazuki Watanabe, Atsuhiko Hattori

    Neural Regeneration Research　20　(6)　1705-1706　2025/06

    Publisher: Medknow

    DOI： 10.4103/nrr.nrr-d-24-00379 　

    ISSN： 1673-5374

    eISSN： 1876-7958

  4. Bone regeneration-enhancing effects by an extremely low frequency electromagnetic fields: Analysis using fish scales as a bone model. Peer-reviewed

    Suzuki, N, Kakikawa, M, Oda, Y, Kobayashi-Sun, J, Yamada, S, Kuroda, K, Kobayashi, I, Honda, M, Matsubara, H, Tabuchi, Y, Shimizu, N, Watanabe, K, Hirayama, J, Hattori, A

    Biomed. Res　45　(5)　187-195　2024/09

  5. Highly purified hypochlorous acid water facilitates glucose metabolism and memory formation in type 2 diabetic mice associated with altered-gut microbiota Peer-reviewed

    Kazuki Watanabe, Yusuke Maruyama, Risako Mikami, Keiji Komatsu, Kenji Kikuchi, Kunimoto Hotta, Toshikazu Yoshikawa, Kouetsu Ogasawara, Atsuhiko Hattori, Shinichi Arakawa

    Scientific Reports　14　(1)　2024/07/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-67129-z 　

    eISSN： 2045-2322

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    Abstract Hypochlorous acid (HOCl) is an endogenous oxidant and chlorinating agent in mammals that is effective against a broad range of microorganisms. However, the effects of exogenous HOCl on biological processes have not been reported. In this study, the effects of highly purified slightly acidic hypochlorous acid water (HP-HAW) were investigated. After the safety of oral administration of HP-HAW was confirmed, the effects of HP-HAW on glucose homeostasis were assessed in mice. HP-HAW treatment significantly improved blood glucose levels in hyperglycemic condition. Based on the 16S rRNA sequencing, HP-HAW treatment significantly increased the diversity and changed the composition of gut microbiota by decreasing the abundance of genus Romboutsia in mice fed normal chow. In obese mice, HP-HAW administration tended to improve glucose tolerance. HP-HAW also attenuated memory impairments and changes N-methyl-d-aspartate (NMDA) receptor mRNA expression in obese mice. HP-HAW treatment suppressed Il-6 mRNA expression in the hippocampus in type 2 diabetic mice. Overall, these results support HP-HAW as a potential therapeutic agent to improve or prevent glucose tolerance and memory decline via gut microbiota alteration.

  6. Theoretical Evaluation of Simultaneous Optical Measurement Method for Hemoglobin Concentration, Oxygen Saturation, and Water Percentage in Blood Based on Multi-parameter Optimization Peer-reviewed

    Masamichi Nogawa, Ikuto Suzuki, Hisashi Naito, Ryotaro Kawashima, Kazuki Watanabe, Shinobu Tanaka, Jun Hirayama

    Journal of Science and Technology in Lighting　2024/05/23

    Publisher: Illuminating Engineering Society of Japan

    DOI： 10.2150/jstl.ieij230000663 　

    ISSN： 2432-3225

    eISSN： 2432-3233

  7. Genetic analysis of impaired healing responses after periodontal therapy in type 2 diabetes: Clinical and in vivo studies Peer-reviewed

    Keita Nakagawa, Kazuki Watanabe, Koji Mizutani, Kohei Takeda, Shu Takemura, Eri Sakaniwa, Risako Mikami, Daisuke Kido, Natsumi Saito, Hiromi Kominato, Atsuhiko Hattori, Takanori Iwata

    Journal of Periodontal Research　59　(4)　712-727　2024/03/19

    Publisher: Wiley

    DOI： 10.1111/jre.13249 　

    ISSN： 0022-3484

    eISSN： 1600-0765

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    Abstract Objective This study aims to investigate the mechanisms underlying the impaired healing response by diabetes after periodontal therapy. Background Outcomes of periodontal therapy in patients with diabetes are impaired compared with those in patients without diabetes. However, the mechanisms underlying impaired healing response to periodontal therapy have not been sufficiently investigated. Materials and Methods Zucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis by ligating the mandibular molars for one week. The gingiva at the ligated sites was harvested one day after ligature removal, and gene expression was comprehensively analyzed using RNA‐Seq. In patients with and without type 2 diabetes (T2D), the corresponding gene expression was quantified in the gingiva of the shallow sulcus and residual periodontal pocket after non‐surgical periodontal therapy. Results Ligation‐induced bone resorption and its recovery after ligature removal were significantly impaired in the ZDF group than in the ZL group. The RNA‐Seq analysis revealed 252 differentially expressed genes. Pathway analysis demonstrated the enrichment of downregulated genes involved in the peroxisome proliferator‐activated receptor (PPAR) signaling pathway. PPARα and PPARγ were decreased in mRNA level and immunohistochemistry in the ZDF group than in the ZL group. In clinical, probing depth reduction was significantly less in the T2D group than control. Significantly downregulated expression of PPARα and PPARγ were detected in the residual periodontal pocket of the T2D group compared with those of the control group, but not in the shallow sulcus between the groups. Conclusions Downregulated PPAR subtypes expression may involve the impaired healing of periodontal tissues by diabetes.

  8. N1‐Acetyl‐5‐methoxykynuramine, which decreases in the hippocampus with aging, improves long‐term memory via CaMKII/CREB phosphorylation Peer-reviewed

    Kazuki Watanabe, Yusuke Maruyama, Hikaru Iwashita, Haruyasu Kato, Jun Hirayama, Atsuhiko Hattori

    Journal of Pineal Research　76　(1)　2024/01

    Publisher: Wiley

    DOI： 10.1111/jpi.12934 　

    ISSN： 0742-3098

    eISSN： 1600-079X

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    Abstract Melatonin is a molecule ubiquitous in nature and involved in several physiological functions. In the brain, melatonin is converted to N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and then to N1‐acetyl‐5‐methoxykynuramine (AMK), which has been reported to strongly enhance long‐term object memory formation. However, the synthesis of AMK in brain tissues and the underlying mechanisms regarding memory formation remain largely unknown. In the present study, young and old individuals from a melatonin‐producing strain, C3H/He mice, were employed. The amount of AMK in the pineal gland and plasma was very low compared with those of melatonin at night; conversely, in the hippocampus, the amount of AMK was higher than that of melatonin. Indoleamine 2, 3‐dioxygenase (Ido) mRNA was expressed in multiple brain tissues, whereas tryptophan 2,3‐dioxygenase (Tdo) mRNA was expressed only in the hippocampus, and its lysate had melatonin to AFMK conversion activity, which was blocked by the TDO inhibitor. The expression levels of phosphorylated cAMP response element binding protein (CREB) and PSD‐95 in whole hippocampal tissue were significantly increased with AMK treatment. Before increasing in the whole tissue, CREB phosphorylation was significantly enhanced in the nuclear fraction. In the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, we found that downregulated genes in hippocampus of old C3H/He mice were more enriched for long‐term potentiation (LTP) pathway. Gene set enrichment analysis showed that LTP and neuroactive receptor interaction gene sets were enriched in hippocampus of old mice. In addition, Ido1 and Tdo mRNA expression was significantly decreased in the hippocampus of old mice compared with young mice, and the decrease in Tdo mRNA was more pronounced than Ido1. Furthermore, there was a higher decrease in AMK levels, which was less than 1/10 that of young mice, than in melatonin levels in the hippocampus of old mice. In conclusion, we first demonstrated the Tdo‐related melatonin to AMK metabolism in the hippocampus and suggest a novel mechanism of AMK involved in LTP and memory formation. These results support AMK as a potential therapeutic agent to prevent memory decline.

  9. Stanniocalcin in the Corpuscles of Stannius Inhibits the Osteoclastic Activation by Regulating the Rankl/Opg Expression Peer-reviewed

    Kouhei Kuroda, Ajai K. Srivastav, Akiko Suzuki, Muhammad Ahya Rafiuddin, Kenji Toyota, Masato Endo, Masato Honda, Kazuki Watanabe, Yusuke Maruyama, Yoshiaki Tabuchi, Atsuhiko Hattori, Makoto Urata, Hajime Matsubara, Nobuo Suzuki

    Journal of Biological Regulators and Homeostatic Agents　37　(10)　5141-5149　2023/10

    DOI： 10.23812/j.biol.regul.homeost.agents.20233710.498 　

  10. Inhabiting Tubes of Beard Worms Discovered in the Deep Sea of Toyama Bay, Japan Peer-reviewed

    Ogiso S, Ohshima S, Mishima H, Hatano K, Takahashi T, Tsutsui H, Morii Y, Yamawaki N, Srivastav AK, Matsubara H, Watanabe K, Hirayama J, Hattori A, Suzuki N

    Int. J. Zoolog. Investig.　9　(2)　486-491　2023/09

  11. Analysis of Seawater Toxicity at Five Concentrated Seawater Discharge Sites in Korea Using a Goldfish Scale-Based In Vitro Bioassay System Peer-reviewed

    Chun-Sang H, Kuroda K, Sato M, Hatano K, Watanabe K, Hirayama J, Sakatoku A, Toyota K, Rafiuddin MA, Matsubara H, Honda M, Srivastav AK, Sungjong L, Suzuki N

    Intern. J. Biol. Environ. Invest.　3　1-8　2023/08

  12. Data on plasma cortisol levels in nibbler fish Girella punctata reared under high-density conditions in either surface seawater or deep ocean water Peer-reviewed

    Takahiro Ikari, Jun Hirayama, Muhammad Ahya Rafiuddin, Yukihiro Furusawa, Yoshiaki Tabuchi, Kazuki Watanabe, Atsuhiko Hattori, Ryotaro Kawashima, Kitaro Nakamura, Ajai K. Srivastav, Kenji Toyota, Hajime Matsubara, Nobuo Suzuki

    Data in Brief　49　109361-109361　2023/08

    Publisher: Elsevier BV

    DOI： 10.1016/j.dib.2023.109361 　

    ISSN： 2352-3409

  13. Melatonin is more effective on bone metabolism when given at early night than during the day in ovariectomized rats Peer-reviewed

    Miki Y, Seki A, Mishima H, Maruyama Y, Watanabe K, Kobayashi-Sun J, Kobayashi I, Kuroda K, Oshima S, Okamoto T, Matsubara H, Srivastav AK, Tabuchi Y, Hirayama J, Hattori A, Suzuki N

    Melatonin Research　6　(2)　161-172　2023/07

  14. Use of biosignal measurements for circadian clock evaluation Peer-reviewed

    Kawashima R, Suzuki I, Watanabe K, Fukuda T, Nogawa M, Hirayama J

    Advances in Health and Disease. (Edited by Lowell T. Duncan) Nova Science Publishers.　66　2023/07

  15. Kynurenine promotes Calcitonin secretion and reduces cortisol in the Japanese flounder Paralichthys olivaceus Peer-reviewed

    Takahiro Ikari, Yukihiro Furusawa, Yoshiaki Tabuchi, Yusuke Maruyama, Atsuhiko Hattori, Yoichiro Kitani, Kenji Toyota, Arata Nagami, Jun Hirayama, Kazuki Watanabe, Atsushi Shigematsu, Muhammad Ahya Rafiuddin, Shouzo Ogiso, Keisuke Fukushi, Kohei Kuroda, Kaito Hatano, Toshio Sekiguchi, Ryotaro Kawashima, Ajai K. Srivastav, Takumi Nishiuchi, Akihiro Sakatoku, Masa-aki Yoshida, Hajime Matsubara, Nobuo Suzuki

    Scientific Reports　13　(1)　2023/05/29

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-023-35222-4 　

    eISSN： 2045-2322

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    Abstract Deep ocean water (DOW) exerts positive effects on the growth of marine organisms, suggesting the presence of unknown component(s) that facilitate their aquaculture. We observed that DOW suppressed plasma cortisol (i.e., a stress marker) concentration in Japanese flounder (Paralichthys olivaceus) reared under high-density condition. RNA-sequencing analysis of flounder brains showed that when compared to surface seawater (SSW)-reared fish, DOW-reared fish had lower expression of hypothalamic (i.e., corticotropin-releasing hormone) and pituitary (i.e., proopiomelanocortin, including adrenocorticotropic hormone) hormone-encoding genes. Moreover, DOW-mediated regulation of gene expression was linked to decreased blood cortisol concentration in DOW-reared fish. Our results indicate that DOW activated osteoblasts in fish scales and facilitated the production of Calcitonin, a hypocalcemic hormone that acts as an analgesic. We then provide evidence that the Calcitonin produced is involved in the regulatory network of genes controlling cortisol secretion. In addition, the indole component kynurenine was identified as the component responsible for osteoblast activation in DOW. Furthermore, kynurenine increased plasma Calcitonin concentrations in flounders reared under high-density condition, while it decreased plasma cortisol concentration. Taken together, we propose that kynurenine in DOW exerts a cortisol-reducing effect in flounders by facilitating Calcitonin production by osteoblasts in the scales.

  16. Nocturnal melatonin increases glucose uptake via insulin-independent action in the goldfish brain Peer-reviewed

    Kazuki Watanabe, Masaki Nakano, Yusuke Maruyama, Jun Hirayama, Nobuo Suzuki, Atsuhiko Hattori

    Frontiers in Endocrinology　14　2023/05/23

    Publisher: Frontiers Media SA

    DOI： 10.3389/fendo.2023.1173113 　

    eISSN： 1664-2392

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    Melatonin, a neurohormone nocturnally produced by the pineal gland, is known to regulate the circadian rhythm. It has been recently reported that variants of melatonin receptors are associated with an increased risk of hyperglycemia and type 2 diabetes, suggesting that melatonin may be involved in the regulation of glucose homeostasis. Insulin is a key hormone that regulates circulating glucose levels and cellular metabolism after food intake in many tissues, including the brain. Although cells actively uptake glucose even during sleep and without food, little is known regarding the physiological effects of nocturnal melatonin on glucose homeostasis. Therefore, we presume the involvement of melatonin in the diurnal rhythm of glucose metabolism, independent of insulin action after food intake. In the present study, goldfish (Carassius auratus) was used as an animal model, since this species has no insulin-dependent glucose transporter type 4 (GLUT4). We found that in fasted individuals, plasma melatonin levels were significantly higher and insulin levels were significantly lower during the night. Furthermore, glucose uptake in the brain, liver, and muscle tissues also significantly increased at night. After intraperitoneal administration of melatonin, glucose uptake by the brain and liver showed significantly greater increases than in the control group. The administration of melatonin also significantly decreased plasma glucose levels in hyperglycemic goldfish, but failed to alter insulin mRNA expression in Brockmann body and plasma insulin levels. Using an insulin-free medium, we demonstrated that melatonin treatment increased glucose uptake in a dose-dependent manner in primary cell cultures of goldfish brain and liver cells. Moreover, the addition of a melatonin receptor antagonist decreased glucose uptake in hepatocytes, but not in brain cells. Next, treatment with N1-acetyl-5-methoxykynuramine (AMK), a melatonin metabolite in the brain, directly increased glucose uptake in cultured brain cells. Taken together, these findings suggest that melatonin is a possible circadian regulator of glucose homeostasis, whereas insulin acquires its effect on glucose metabolism following food intake.

  17. Adaptation to the shallow sea floor environment of a species of marine worms, Oligobrachia mashikoi, generally inhabiting deep-sea water

    Shouzo Ogiso, Kazuki Watanabe, Yusuke Maruyama, Hiroshi Miyake, Kaito Hatano, Jun Hirayama, Atsuhiko Hattori, Yukina Watabe, Toshio Sekiguchi, Yoichiro Kitani, Yukihiro Furusawa, Yoshiaki Tabuchi, Hajime Matsubara, Mana Nakagiri, Kenji Toyota, Yuichi Sasayama, Nobuo Suzuki

    Scientific Reports　13　(1)　2023/04/18

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-023-33309-6 　

    eISSN： 2045-2322

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    Abstract Beard worms from the family Siboglinidae, are peculiar animals and are known for their symbiotic relationships with sulfur bacteria. Most Siboglinids inhabit the deep-sea floor, thus making difficult to make any observations in situ. One species, Oligobrachia mashikoi, occurs in the shallow depths (24.5 m) of the Sea of Japan. Taking advantage of its shallow-water habitat, the first ecological survey of O. mashikoi was performed over a course of 7 years, which revealed that its tentacle-expanding behavior was dependent on the temperature and illuminance of the sea water. Furthermore, there were significantly more O. mashikoi with expanding tentacles during the nighttime than during the daytime, and the prevention of light eliminated these differences in the number of expending tentacles. These results confirmed that the tentacle-expanding behavior is controlled by environmental light signals. Consistent with this, we identified a gene encoding a photoreceptor molecule, neuropsin, in O. mashikoi, and the expression thereof is dependent on the time of day. We assume that the described behavioral response of O. mashikoi to light signals represent an adaptation to a shallow-water environment within the predominantly deep-sea taxon.

  18. Osteoclastic and Osteoblastic Responses to Hypergravity and Microgravity: Analysis Using Goldfish Scales as a Bone Model Peer-reviewed

    Tatsuki Yamamoto, Mika Ikegame, Yukihiro Furusawa, Yoshiaki Tabuchi, Kaito Hatano, Kazuki Watanabe, Umi Kawago, Jun Hirayama, Sachiko Yano, Toshio Sekiguchi, Kei-ichiro Kitamura, Masato Endo, Arata Nagami, Hajime Matsubara, Yusuke Maruyama, Atsuhiko Hattori, Nobuo Suzuki

    Zoological Science　39　(4)　2022/04/05

    Publisher: Zoological Society of Japan

    DOI： 10.2108/zs210107 　

    ISSN： 0289-0003

  19. Effects of Antioxidant in Adjunct with Periodontal Therapy in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Peer-reviewed

    Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata

    Antioxidants　10　(8)　2021/08

    DOI： 10.3390/antiox10081304 　

    ISSN： 2076-3921

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    This review investigated whether the adjunctive use of antioxidants with periodontal therapy improves periodontal parameters in patients with type 2 diabetes. A systematic and extensive literature search for randomized controlled trials (RCTs) conducted before April 2021 was performed on the PubMed, Cochrane Library, and Web of Science databases. The risk of bias was assessed using the Cochrane risk-of-bias tool. A meta-analysis was performed to quantitatively evaluate the clinical outcomes following periodontal therapy. After independent screening of 137 initial records, nine records from eight RCTs were included. The risk-of-bias assessment revealed that all RCTs had methodological weaknesses regarding selective bias, although other risk factors for bias were not evident. This meta-analysis of two RCTs showed that periodontal pocket depths were significantly reduced in the groups treated with combined non-surgical periodontal therapy and melatonin than in those treated with non-surgical periodontal therapy alone. The present systematic review and meta-analysis suggest that the adjunctive use of melatonin, resveratrol, omega-3 fatty acids with cranberry juice, propolis, and aloe vera gel with periodontal therapy significantly improves periodontal disease parameters in patients with type 2 diabetes, and melatonin application combined with non-surgical periodontal therapy might significantly reduce periodontal pocket depth. However, there are still limited studies of melatonin in combination with non-surgical periodontal therapy in Type 2 diabetic patients, and more well-designed RCTs are required to be further investigated.

  20. Associations of homocysteine metabolism with the risk of spinal osteoarthritis progression in postmenopausal women. Peer-reviewed

    Nakano M, Nakamura Y, Urano T, Miyazaki A, Suzuki T, Watanabe K, Takahashi J, Shiraki M

    The Journal of clinical endocrinology and metabolism　2021/08

    DOI： 10.1210/clinem/dgab591 　

    ISSN： 0021-972X

  21. The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice Peer-reviewed

    Iwashita Hikaru, Matsumoto Yukihisa, Maruyama Yusuke, Watanabe Kazuki, Chiba Atsuhiko, Hattori Atsuhiko

    JOURNAL OF PINEAL RESEARCH　70　(1)　e12703　2021/01

    Publisher: Wiley

    DOI： 10.1111/jpi.12703 　

    ISSN： 0742-3098

    eISSN： 1600-079X

  22. Comprehensive and Sequential Gene Expression Analysis of Bone Healing Process Following Er:YAG Laser Ablation International-journal Peer-reviewed

    Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Hatasa M, Mizutani K, Watanabe K, Niimi H, Iwata T, Aoki A

    Photobiomodulation, Photobiomedicine, and Laser Surgery　39　(2)　100-112　2020/12

    DOI： 10.1089/photob.2020.4833 　

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    Objective: This study evaluated the comprehensive and sequential gene expression in laser-ablated bone compared with that in nontreated control bone. Background: Bone ablation by Er:YAG laser has shown positive effects on bone healing; however, the gene expression responses that occur during bone healing remain unclear. Materials and methods: The calvarial bone of male, 10-week-old Wistar rats was ablated by Er:YAG laser. Gene expression in the laser-ablated bone and nontreated control bone was evaluated at 6, 24, and 72 h using microarray analysis. Messenger RNA (mRNA) expression levels were validated by quantitative reverse transcription-polymerase chain reaction. Results: Gene expression of BCAR1/p130Cas (breast cancer anti-estrogen resistance 1/p130 Crk-associated substrate), a mechanotransducer, was gradually increased. Additionally, upstream of the Hippo signaling pathway was enriched according to Kyoto Encyclopedia of Genes and Genomes pathway analysis at 6 h. F-actin mRNA expression was also gradually increased, whereas the Hippo signaling pathway was downregulated from 6 to 24 h. Enrichment of bone formation-related Gene Ontology (GO) terms was observed from an early stage, whereas inflammation-related GO terms, gene sets, and mRNA expression of Nfkb1, Tnf, and Il1b were gradually enriched after 24 h. Conclusions: Bone ablation by Er:YAG laser regulated the expression of Bcar1 and Actg1, the main regulators of mechanotransduction in the bone tissue. Additionally, inflammation was gradually increased up to 72 h following bone ablation with Er:YAG laser. Laser influences the expression of genes associated with bone formation immediately after irradiation. Therefore, mechanical stress and the biological effects caused by Er:YAG laser irradiation potentially contribute to wound healing in the laser-ablated bone tissue.

  23. Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota International-journal Peer-reviewed

    Watanabe K, Katagiri S, Takahashi H, Sasaki N, Maekawa S, Komazaki R, Hatasa M, Kitajima Y, Maruyama Y, Shiba T, Komatsu K, Ohsugi Y, Tanaka K, Matsuzawa A, Hirota T, Tohara H, Eguchi Y, Anzai K, Hattori A, Iwata T

    The FASEB Journal, Tokyo Medical and Dental University　35　(2)　e21171　2020/11

    DOI： 10.1096/fj.202001158R 　

    ISSN： 0892-6638

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    Skeletal muscles have a high metabolic capacity, which play key roles in glucose metabolism. Although periodontal disease increases the risk of metabolic syndrome, the relationship between periodontal bacterial infection and skeletal muscle metabolic dysfunction is unclear. We found that anti-Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue content (IMAC), fasting blood glucose, and HOMA-IR in metabolic syndrome patients. In C57BL/6J mice fed a high-fat diet, recipients of oral Pg (HFPg) had impaired glucose tolerance, insulin resistance, and higher IMAC compared to recipients of saline (HFco). The soleus muscle in HFPg mice exhibited fat infiltration and lower glucose uptake with higher Tnfa expression and lower insulin signaling than in HFco mice. Gene set enrichment analysis showed that TNFα signaling via NFκB gene set was enriched in the soleus muscle of HFPg mice. Moreover, TNF-α also decreased glucose uptake in C2C12 myoblast cells in vitro. Based on 16S rRNA sequencing, Pg administration altered the gut microbiome, particularly by decreasing the abundance of genus Turicibacter. Microbial network of the gut microbiome was dramatically changed by Pg administration. Our findings suggest that infection with Pg is a risk factor for metabolic syndrome and skeletal muscle metabolic dysfunction via gut microbiome alteration.

  24. Laser irradiation decreases sclerostin expression in bone and osteogenic cells. Peer-reviewed

    Ohsugi Y, Katagiri S, Hirota T, Niimi N, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A

    The FASEB Journal　34　(9)　12877-12893　2020/08

    Publisher: John Wiley & Sons

    ISSN： 0892-6638

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    Anti-sclerostin monoclonal antibody romosozumab, a treatment for osteoporosis, reduced vertebral fracture risk and clinical fracture. Laser irradiation triggers various effects, including bio-stimulation, which can induce beneficial therapeutic effects and biological responses. Originally, we performed in vivo experiments to clarify the mechanism of better bone healing in laser-ablated bone. Here, we evaluated comprehensive and sequential gene expression in Er:YAG laser-ablated, bur-drilled, and nontreated control bones, and found laser irradiation suppressed Sost (coding protein: sclerostin) expression in the bone, possibly via stimulation of mechanotransducers. Surprisingly, bio-stimulation effect of laser suppressed Sost expression in the primary osteogenic cells. Decreased sclerostin expression after laser irradiation was also validated both in vivo and in vitro. In addition, sequential microarray analysis revealed that the gene expression pattern was clearly different at 24 hours after bone ablation between bur-drilled and laser-ablated bones. The Hippo signaling pathway was significantly enriched, whereas inflammation-related pathways were not affected at 6 hours after the laser ablation, indicating that laser irradiation caused mechanical stimulation. Only bur-drilled bone showed enriched inflammation-related gene sets and pathways at 24 hours, not in the laser-ablated bone. Our study suggests that laser irradiation may become a new treatment modality for osteoporosis, by inhibiting sclerostin expression without inducing inflammation.

  25. Combined effect of canagliflozin and exercise training on high-fat diet-fed mice Peer-reviewed

    Kenichi Tanaka, Hirokazu Takahashi, Sayaka Katagiri, Kazuyo Sasaki, Yujin Ohsugi, Kazuki Watanabe, Islam M. D. Rasadul, Keiichiro Mine, Seiho Nagafuchi, Takanori Iwata, Yuichiro Eguchi, Keizo Anzai

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM　318　(4)　E492-E503　2020/04

    DOI： 10.1152/ajpendo.00401.2019 　

    ISSN： 0193-1849

    eISSN： 1522-1555

  26. Melatonin and glucose metabolism. Peer-reviewed

    Kazuki Watanabe, Sayaka Katagiri, Atsuhiko Hattori

    Glycative Stress Research　7　(1)　105-109　2020/03

  27. Effects of Low-Level Er:YAG Laser Irradiation on Proliferation and Calcification of Primary Osteoblast-Like Cells Isolated From Rat Calvaria. International-journal Peer-reviewed

    Hiromi Niimi, Yujin Ohsugi, Sayaka Katagiri, Kazuki Watanabe, Masahiro Hatasa, Tsuyoshi Shimohira, Yosuke Tsuchiya, Shogo Maekawa, Tomomitsu Hirota, Hiroshi Kadokura, Satoshi Yokose, Takanori Iwata, Akira Aoki

    Frontiers in cell and developmental biology　8　459-459　2020

    DOI： 10.3389/fcell.2020.00459 　

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    Several reports have shown that the photo-bio-modulation of cells by various lasers has favorable biological effects. However, the effects of low-level Er:YAG laser irradiation on osteoblasts remain unclear. The purpose of this study was to evaluate the effects of low-level Er:YAG laser irradiation on proliferation and osteogenic differentiation of primary osteoblast-like cells isolated from the calvariae of 3-5-day-old Wistar rats. Cells were irradiated by Er:YAG laser at energy fluences of 2.2, 3.3, and 4.3 J/cm2, respectively. After irradiation, cell surface temperatures were measured and cell proliferation was evaluated by flow cytometry and CCK-8. Calcification was evaluated by measuring areas of Alizarin red S staining after 7, 14, and 21 days culture in osteoinductive medium. Gene expression in non-irradiated and laser-irradiated cells was evaluated by qPCR at 3, 6, and 12 h, as well as 1, 3, 7, and 14 days after irradiation. Microarray analysis was performed to comprehensively evaluate the gene expression of non-irradiated and irradiated cells at 3.3 J/cm2 at 6 h after irradiation. No pronounced increase of cell surface temperature was induced by irradiation. Irradiation did not affect osteoblast-like cell proliferation. Osteoblast-like cell calcification was significantly increased 7 days after Er:YAG laser irradiation at 3.3 J/cm2. Bglap expression was significantly increased in cells irradiated at 3.3 J/cm2 6 h post-irradiation. Microarray analysis showed that irradiation at 3.3 J/cm2 caused an upregulation of inflammation-related genes and downregulation of Wisp2. Gene set enrichment analysis also clarified enrichment of inflammation-related and Notch signaling gene sets. In conclusion, low-level Er:YAG laser irradiation at 3.3 J/cm2 enhanced calcification of primary osteoblast-like cells via enhanced Bglap expression and enriched Notch signaling.

  28. Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities Peer-reviewed

    Sayaka Katagiri, Takahiko Shiba, Haruka Tohara, Kohei Yamaguchi, Koji Hara, Kazuharu Nakagawa, Keiji Komatsu, Kazuki Watanabe, Yujin Ohsugi, Shogo Maekawa, Takanori Iwata

    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY　9　2019/12

    DOI： 10.3389/fcimb.2019.00434 　

    ISSN： 2235-2988

  29. RNA sequencing for ligature induced periodontitis in mice revealed important role of S100A8 and S100A9 for periodontal destruction Peer-reviewed

    Shogo Maekawa, Satoru Onizuka, Sayaka Katagiri, Masahiro Hatasa, Yujin Ohsugi, Naoki Sasaki, Kazuki Watanabe, Anri Ohtsu, Rina Komazaki, Kohei Ogura, Tohru Miyoshi-Akiyama, Takanori Iwata, Hiroshi Nitta, Yuichi Izumi

    SCIENTIFIC REPORTS　9　2019/10

    DOI： 10.1038/s41598-019-50959-7 　

    ISSN： 2045-2322

  30. Ozone Ultrafine Bubble Water improves wound healing via modification of inflammation Peer-reviewed

    Watanabe K, Ohsugi Y, Maekawa S, Sasaki N, Shiba T, Katagiri S, Arakawa S

    The Journal of the Stomatological Society　86　(2)　25-34　2019/07

  31. Gadolinium at Low Concentration Suppresses both Osteoclastic and Osteoblastic Activities in the Scales of Goldfish Peer-reviewed

    Nobuo Suzuki, Kazuki Watanabe, Aika Sekimoto, Makoto Urata, Mohamed Ibrahim Zanaty, Toshio Sekiguchi, Yoichiro Kitani, Hajime Matsubara, Ajai Kumar Srivastav, Atsuhiko Hattori

    American Journal of Environmental Sciences　15　(4)　137-144　2019/04/01

    Publisher: Science Publications

    DOI： 10.3844/ajessp.2019.137.144 　

    ISSN： 1553-345X

  32. Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice Peer-reviewed

    Naoki Sasaki, Sayaka Katagiri, Rina Komazaki, Kazuki Watanabe, Shogo Maekawa, Takahiko Shiba, Sayuri Udagawa, Yasuo Takeuchi, Ann Ohtsu, Takashi Kohda, Haruka Tohara, Naoyuki Miyasaka, Tomomitsu Hirota, Mayumi Tamari, Yuichi Izumi

    FRONTIERS IN MICROBIOLOGY　9　2018/10

    DOI： 10.3389/fmicb.2018.02470 　

    ISSN： 1664-302X

  33. Effect of Porphyromonas gingivalis infection in the placenta and umbilical cord in pregnant mice with low birth weight. International-journal Peer-reviewed

    Sayuri Udagawa, Sayaka Katagiri, Shogo Maekawa, Yasuo Takeuchi, Rina Komazaki, Anri Ohtsu, Naoki Sasaki, Takahiko Shiba, Kazuki Watanabe, Kazuyuki Ishihara, Noriko Sato, Naoyuki Miyasaka, Yuichi Izumi

    Acta odontologica Scandinavica　76　(6)　433-441　2018/08

    DOI： 10.1080/00016357.2018.1426876 　

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    OBJECTIVE: Growing evidence indicates an association between periodontitis and delivery outcome; however, the mechanism is unclear. This study aimed to investigate the influence of Porphyromonas gingivalis (Pg) infection on delivery outcome in mice. MATERIALS AND METHODS: Bacteremia was induced in pregnant Slc:ICR mice (8 weeks old) by intravenous injection of Pg. Mice were randomly divided into a control group (CO), and those receiving Pg injection at gestational day 1 (GD1), gestational day 15 (GD15) or every day (ED). Delivery outcome, Pg infection, and gene expression in the placenta and umbilical cord were evaluated. RESULTS: Birth weight was lower in the ED and GD15 groups than in the CO group. A remarkable increase in anti-Pg IgG antibody was observed in the ED and GD1 groups, although Pg was not detected in the placenta or umbilical cord. mRNA expression of Tnfα and Il6 in the placenta, and Hif1α in the umbilical cord, was significantly increased in the ED group. Microarray analysis of the umbilical cord revealed increased expression of several genes including Orm1, Mgl2, Rps6ka3 and Trim15 in the ED group. CONCLUSIONS: Pg infection during the third trimester caused low birth weight and inflammation in the placenta and umbilical cord.

  34. Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism (vol 7, 2017) Peer-reviewed

    Rina Komazaki, Sayaka Katagiri, Hirokazu Takahashi, Shogo Maekawa, Takahiko Shiba, Yasuo Takeuchi, Yoichiro Kitajima, Anri Ohtsu, Sayuri Udagawa, Naoki Sasaki, Kazuki Watanabe, Noriko Sato, Naoyuki Miyasaka, Yuichiro Eguchi, Keizo Anzai, Yuichi Izumi

    SCIENTIFIC REPORTS　8　2018/03

    DOI： 10.1038/s41598-018-23000-6 　

    ISSN： 2045-2322

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Misc. 7

  1. 東京医科歯科大学歯学部歯学科学生の歯周治療臨床実習の改革とその現状 2018年卒業生の実習内容とその実績から

    青木 章, 竹内 康雄, 秋月 達也, 水谷 幸嗣, 片桐 さやか, 池田 裕一, 前川 祥吾, 渡辺 数基, 海老原 新, 秀島 雅之, 二階堂 徹, 小田 茂, 荒木 孝二, 岩田 隆紀, 和泉 雄一

    日本歯周病学会会誌　62　(1)　38-46　2020/03

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  2. 炎症・感染と脳卒中(臨床研究) 歯周病と脳卒中

    片桐 さやか, 大杉 勇人, 渡辺 数基, 前川 祥吾, 芝 多佳彦

    The Mt. Fuji Workshop on CVD　37　123-128　2019/07

    Publisher: (株)にゅーろん社

    ISSN： 0289-8438

    More details Close

    脳卒中後の経管栄養患者5例を対象に、口腔内および腸内細菌叢の評価を行った。口腔内細菌叢の解析は唾液、腸内細菌叢の解析は便を試料とし、細菌のDNAを調査した。その結果、operational taxonomic unit数、Shannon index、Chaol indexともに口腔内サンプルの方が腸内サンプルより有意に低値を示し、口腔内と腸内では細菌叢の多様性が有意に異なることが示唆された。Principal coordinate analysisでは、細菌叢は腸内および口腔内で近い細菌叢であることが示された。口腔内および腸内の細菌叢組成を門レベルで示すと、口腔内細菌叢はFirmicutes門が腸内細菌叢より高い傾向にあり、Proteobacteria門が腸内細菌叢より低い傾向にあった。口腔内および腸内での細菌叢の機能予測解析の結果、Level 1での機能予測解析でhuman diseaseおよびgenetic information processingに関する機能遺伝子の発現が有意に異なることが予測された。

  3. 結紮誘導歯周炎マウスの炎症歯周組織におけるRNAシーケンスを用いた発現変動遺伝子の解析

    前川 祥吾, 鬼塚 理, 片桐 さやか, 佐々木 直樹, 渡辺 数基, 大津 杏理, 駒崎 利奈, 小倉 康平, 秋山 徹, 新田 浩, 和泉 雄一, 岩田 隆紀

    日本歯周病学会会誌　61　(春季特別)　124-124　2019/05

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

  4. 歯周病と全身の健康との関わり

    和泉 雄一, 佐々木 直樹, 渡辺 数基, 前川 祥吾, 片桐 さやか

    有病者歯科医療　27　(5)　325-338　2018/11

    Publisher: (一社)日本有病者歯科医療学会

    ISSN： 0918-8150

    eISSN： 1884-667X

  5. Porphyromonas gingivalisによる内毒素血症が引き起こす、非アルコール性脂肪性肝疾患への影響と、糖・脂質代謝、腸内細菌叢の変化

    佐々木 直樹, 片桐 さやか, 駒崎 利奈, 渡辺 数基, 前川 祥吾, 芝 多佳彦, 竹内 康雄, 大津 杏理, 和泉 雄一

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集　149回　50-50　2018/10

    Publisher: (NPO)日本歯科保存学会

  6. 在宅における摂食嚥下を考える 課題に気づきアセスメントしよう(第6回) 口腔内細菌と全身疾患とのかかわり

    渡辺 数基, 片桐 さやか

    在宅新療0→100　3　(6)　504-505　2018/06

    Publisher: (株)へるす出版

  7. 東京医科歯科大学歯学部第5・第6学年の歯周治療臨床実習の現状

    青木 章, 竹内 康雄, 秋月 達也, 水谷 幸嗣, 片桐 さやか, 池田 裕一, 前川 祥吾, 渡辺 数基, 松浦 孝典, 大津 杏理, 柿崎 翔, 駒崎 利奈, 三上 理沙子, 秀島 雅之, 二階堂 徹, 荒木 孝二, 和泉 雄一

    日本歯周病学会会誌　60　(春季特別)　134-134　2018/05

    Publisher: (NPO)日本歯周病学会

    ISSN： 0385-0110

    eISSN： 1880-408X

Show all ︎Show first 5

Books and Other Publications 1

  1. 快眠研究と製品開発、社会実装;高齢者のメラトニン産生と睡眠の質

    渡辺数基、服部淳彦.

    エヌ・ティー・エス　2022/06

Presentations 50

  1. Porphyromonas gingivalis 由来 LPS は神経細胞のグルコース代謝障害を引き起こす

    渡辺 数基, 小笠原 康悦

    第67回歯科基礎医学会学術大会　2025/09/07

  2. 歯周病原細菌Porphyromonas gingivalis由来LPSがミクログリアのアルツハイマ ー型認知症関連因子に与える影響の解明

    渡辺数基, JAW Xinyi, 西屋敷 駿, 加藤かれん, 徳川裕久, 和知祐太朗, 平山 順, 小笠原康悦

    第77回日本細菌学会東北支部学術集会　2025/08/21

  3. がんを攻撃するキラーT細胞のトロゴサイトーシス

    加藤かれん, 渡辺数基, 小笠原康悦

    第77回日本細菌学会東北支部学術集会　2025/08/21

  4. A melatonin metabolite N1-acetyl-5-methoxykynuramine regulates memory-related factors on SH-SY5Y human neuroblastoma cells; the mechanisms on facilitating memory formation

    Kazuki Watanabe, Atsuhiko Hattori, Kouetsu Ogasawara

    19th International Congress of Comparative Endocrinology　2025/07/09

  5. メラトニン代謝産物AMK による認知機能増強作用とグルコース代謝制御に着目した認知症予防法の開発 Invited

    渡辺数基

    第25回日本抗加齢医学会総会　2025/06/15

  6. Porphyromonas gingivalis 由来 LPS が神経芽細胞に与える直接的影響の解析

    渡辺数基, 小笠原康悦

    第66回歯科基礎医学会総会　2024/11

  7. 歯周病原細菌Porphyromonas gingivalis由来LPSが神経細胞に与える影響の網羅的解析

    渡辺数基, 加藤かれん, 西屋敷駿, Louisa Yokebed, Bruel, 平山順, 小笠原康悦

    第７６回日本細菌学会東北支部会 総会・学術集会　2024/08/19

  8. メラトニン代謝産物AMKがアストロサイト―マ細胞株のグルコース取り込みに与える影響の解明

    渡辺数基, 丸山雄介, 平山順, 服部淳彦

    第24回日本抗加齢医学会総会　2024/05

  9. 高血糖を引き起こしたキンギョの骨代謝に及ぼす影響

    黒田康平, 丸山雄介, 渡辺数基, 遠藤雅人, 松原 創, 田渕圭章, 平山 順, 服部淳彦, 鈴, 木信雄

    令和 6 年度公益社団法人日本水産学会春季大会　2024/03/27

  10. 宇宙飛行士の様々な疾患の治療薬として有効なメラトニンに関する研究

    鈴木信雄, 平山 順, 高橋昭久, 黒田康平, 保田夏野, 田渕圭章, 古澤之裕, 池亀美華, 渡辺数基, 丸山雄介, 松原 創, 中野貴由, 木村廣美, 河島遼太郎, 三島弘幸, 加藤晴康, 関 あずさ, 服部淳彦

    第 38 回宇宙環境利用シンポジウム　2024/01/16

  11. 海洋深層水に含まれる有機成分（キヌレニン）は海 産魚のストレスを軽減する

    鈴木信雄, 五十里雄大, 黒田康平, 端野開都, 平山 順, 渡辺数基, 古澤之裕, 田渕圭章, 丸, 山雄介, 服部淳彦, 豊田賢治, 松原 創

    第 27 回海洋深層水利用学会全国大会　2023/12/06

  12. Effects of staniocalcin, a blood calcium-regulating hormone, on osteoblasts and osteoclasts in goldfish scales.

    Kuroda, K, Srivastav, A.K, Suzuki, A, Rafiuddin, M.A, Toyota, K, Endo, M, Honda, M, Watanabe, K, Maruyama, Y, Tabuchi, Y, Hattori, A, Urata, M, Matsubara, H, Suzuki, N

    International Symposium: Environmental Issues in a Post-Covid 19 Society　2023/12/06

  13. 宇宙空間における新規メラトニン誘導体のウロコ（骨モデル）に対する効果と地上にお ける骨疾患モデルラットを用いた解析

    鈴木信雄, 古澤之裕, 田渕圭章, 豊田賢治, 関 あずさ, 高垣裕子, 染井正徳, 江尻貞一, 池亀美華, 黒田康平, 丸山雄介, 渡辺数基, 関口俊男, 松原 創, 高橋昭久, 平山 順, 服部淳彦

    令和 5 年度日本動物学会中部支部大会　2023/12/02

  14. 高血糖により引き起こされる骨疾患を解析するための高血糖モデル魚の開発

    黒田康平, 丸山雄介, 渡辺数基, 豊田賢治, 松原創, 平山順, 服部淳彦, 鈴木信雄

    第47回日本比較内分泌学会大会　2023/11/18

  15. 高血 糖により引き起こされる骨疾患を解析するための高血糖モデル魚の開発

    黒田康平, 丸山雄介, 渡辺数基, 豊田賢治, 松原 創, 平山 順, 服部淳彦, 鈴木信雄

    第 47 回日本比較内分泌学会大会　2023/11/17

  16. キヌレニンはアオゴカイの夜間での行動に関与する

    大嶋詩響, 小木曽正造, 豊田賢治, 渡辺数基, 平山 順, 丸山雄介, 服部淳彦, 松原 創, 鈴木信雄

    第 1 回環日本海生命科学研 究会　2023/09/19

  17. スタニオカルシンは、 Rankl/Opg の発現を制御することにより破骨細胞の活性を抑制する

    黒田康平, Srivastav AK, 鈴木晶子, Rafiuddin MA, 豊田賢治, 本田匡人, 遠藤雅人, 渡辺数基, 丸山雄介, 服部淳彦, 田渕圭章, 浦田 慎, 松原 創, 鈴木信雄

    第 1 回環日本海生命科 学研究会　2023/09/19

  18. Social contexts mediate reward systems in a cricket Gryllus bimaculatus

    Terao K, Kosaki Y, Maruyama Y, Watanabe K, Kataoka K, Hattori A, Matsumoto Y

    Non-Traditional Arthropod Model Systems: Studying Form and Function　2023/08

  19. メラトニン関連インドール化合物による最終糖化産物（AGEs）の架橋切断及び架橋形成阻害効果

    丸山 雄介, 渡辺 数基, 加藤 晴康, 服部 淳彦

    第23回日本抗加齢医学会総会　2023/06/10

  20. 記憶増強作用を持つメラトニン代謝産物AMKの低用量長期投与が記憶形成能と血中生化学パラメーターに与える影響

    渡辺数基, 丸山雄介, 平山順, 服部淳彦

    第23回日本抗加齢医学会総会　2023/06/09

  21. 糖尿病モデルラットにおける実験的歯周炎の治癒期の網羅的遺伝子発現解析

    中川佳太, 水谷幸嗣, 渡辺数基, 齋藤夏実, 竹村修, 坂庭愛理, 三上理沙子, 城戸大輔, 武田浩平, 小湊広美, 服部淳彦, 岩田隆紀

    第66回春季日本歯周病学会学術大会　2023/05/26

  22. ⻑期記憶誘導作用を持つメラトニン代謝産物AMKの加齢変化と記憶関連因子に与える影響

    渡辺数基, 丸山雄介, 服部淳彦

    第41回日本認知症学会学術集会 第37回日本老年精神医学会［合同開催］　2022/11/26

  23. がんの骨浸潤時に上昇する低酸素誘導因子 HIF による破骨細胞の調節機構－キン ギョの再生鱗を用いて

    飯田穀, 福井宏明, 丸山雄介, 渡辺数基, 鈴木信雄, 服部淳彦

    第 46 回日本比較内分泌学会大会及びシンポジウム　2022/10/29

  24. メラトニン代謝産物 N-acetyl-5-methoxykynuramine（AMK）はキンギョの脳におけ る記憶形成関連因子を促進する

    榊原和眞, 渡辺数基, 丸山雄介, 服部淳彦

    第 46 回日本比較内分泌学会大会及びシンポジウム　2022/10/29

  25. キンギョにおける学習・記憶試験 Object Recognition Test（ORT）の確立

    毛利有沙, 田中美咲妃, 渡辺数基, 丸山雄介, 服部淳彦

    第 46 回日本比較内分泌学会大会及びシンポジウム　2022/10/29

  26. 高純度次亜塩素酸水がマウスの糖代謝に与える影響の解明

    渡辺数基, 丸山雄介, 三上理沙子, 駒津匡二, 服部淳彦, 荒川真一

    日本機能水学会第20回学術大会　2022/10/22

  27. 特異的に浅海に棲むマシコヒゲム シ Oligobrachia mashikoi の生 息状況及び光環境への適応

    小木曽正造,渡辺数基,三宅裕志,丸山雄介,平山順,服部淳彦,関口俊男,端野開都,木谷洋一郎,渡部雪菜,松原創,笹山雄一,鈴木信雄

    第93回日本動物学会　2022/09/10

  28. 加齢性記憶障害におけるメラトニン代謝産物による学習記憶増強作用 Invited

    渡辺数基

    第22回日本抗加齢医学会総会　2022/06/19

  29. 長期記憶を誘導するメラトニン代謝産物 AMK はキンギョの脳における 記憶形成関連因子を促進する

    榊原和眞, 野田武志, 久世拓希, 渡辺数基, 服部淳彦

    日本動物学会関東支部第74回大会　2022/03/04

  30. マウスにおけるメラトニン代謝産物 AMK の加齢変化と長期記憶誘導作用のメカニズムの解明

    渡辺数基, 丸山雄介, 服部淳彦

    第45回日本比較内分泌学会大会　2021/11/13

  31. Sequential microarray analysis of Er:YAG laser ablated bone tissue International-presentation

    Ohsugi Y, Katagiri S, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kadokura H, Yokose S, Iwata T, Aoki A

    The 99th General Session of the IADR　2021/07/21

  32. Endotoxemia by Porphyromonas gingivalis aggravates inflammation in brown adipose tissue International-presentation

    Hatasa M, Ohsugi Y, Katagiri S, Hirota T, Yoshida S, Morita K, Niimi H, Shimohira T, Watanabe K, Sasaki N, Maekawa S, Nitta H, Iwata T

    AAP 106th Annual Meeting　2020/11/06

  33. The effects of Er:YAG laser irradiation on primary osteoblast-like cells International-presentation

    Niimi H, Ohsugi Y, Katagiri S, Watanabe K, Hatasa M, Shimohira T, Tsuchiya Y, Maekawa S, Hirota T, Kadokura H, Yokose S, Iwata T, Aoki A

    AAP 106th Annual Meeting　2020/11/06

  34. Laser irradiation decreases Sost expression in bone and osteogenic cells International-presentation

    Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A

    The 106th Annual meeting American Academy of Periodontology　2020/11

  35. Porphyromonas gingivalisは腸内細菌叢を変化させ、骨格筋における糖取り込みを阻害する

    渡辺数基

    第63回秋季日本歯周病学会学術大会　2020/10/16

  36. Effects of low-level Er:YAG laser irradiation on proliferation and calcification of primary osteoblast-like cells isolated from rat calvaria

    2020/10/16

  37. Er:YAG laser irradiation decreases sclerostin expression in bone and osteogenic cell

    Ohsugi Y, Katagiri S, Hirota T, Niimi H, Hatasa M, Watanabe K, Shimohira T, Mizutani K, Kitazawa M, Matsuzawa A, Kadokura H, Yokose S, Iwata T, Aoki A

    The 63th Autumn Meeting of The Japanese Society of Periodontology　2020/10

  38. メラトニンの代謝産物N-acetly-5-methoxykynuramineはマウスにおける加齢性記憶障害を改善する－海馬における糖取り込みへの関与

    渡辺数基, 岩下洸, 丸山雄介, 千葉篤彦, 片桐さやか, 岩田隆紀, 服部淳彦

    第20回日本抗加齢医学会総会　2020/09/25

  39. Comprehensive and sequential gene expression analysis during bone healing process following Er:YAG laser ablation

    Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Hatasa M, Mizutani K, Watanabe K, Niimi H, Iwata T, Aoki A

    第63回春季日本歯周病学会　2020/07/13

  40. Comprehensive and Sequential Gene expression analysis of bone healing process following Er:YAG laser ablation International-presentation

    Shimohira T, Katagiri S, Ohsugi Y, Hirota T, Mizutani K, Watanabe K, Niimi H, Hatasa M, Meinzer W, Iwata T, Aoki A

    World Federation of Laser Dentistry Dubai Congress 2020　2020/02/05

  41. Microarray analysis of comprehensive gene expression in rat calvarial bone after Er:YAG laser ablation International-presentation

    Ohsugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Hatasa M, Shimohira T, Meinzer W, Hirota T, Iwata T, Aoki A

    The first asian pacific division of the World Federation for Laser Dentistry　2019/11/10

  42. Comprehensive gene expression analysis in rat calvarial bone after ablation with Er:YAG laser and the effects of Er:YAG laser on osteocytes International-presentation

    Ohsugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Meinzer W, Hirota T, Iwata T, Aoki A

    The 105th Annual meeting American Academy of Periodontology　2019/11/03

  43. 結紮誘導歯周炎マウスの炎症歯周組織におけるRNAシーケンスを用いた発現変動遺伝子の解析

    前川祥吾, 鬼塚理, 片桐さやか, 佐々木直樹, 渡辺数基, 大津杏理, 駒崎利奈, 小倉康平, 秋山徹, 新田浩, 和泉雄一, 岩田隆紀

    第62回春季日本歯周病学会学術大会　2019/05/24

  44. 夜間のメラトニンはインスリンを介さずにキンギョの糖代謝を調節している

    渡辺数基, 中野真樹, 丸山雄介, 服部淳彦

    日本比較内分泌学会　2018/11/10

  45. Endotoxemia by Porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice

    Naoki Sasaki, Sayaka Katagiri, Rina Komazaki, Kazuki Watanabe, Shogo Maekawa, Takahiko Shiba, Yasuo Takeuchi, Anri Ohtsu, Yuichi Izumi

    日本歯科保存学会2018年秋季学術大会　2018/11/02

  46. The current state of periodontal therapy clinical practice at the 5th and 6th grades of Tokyo medical and dental university

    Aoki A, Takeuchi Y, Akizuki T, Mizutani K, Katagiri S, Ikeda Y, Maekawa S, Watanabe K, Matsuura T, Ohtsu A, Kakizaki S, Komazaki R, Mikami R, Hideshima M, Nikaidou T, Araki K, Izumi Y

    The 61th Spring Meeting of The Japanese Society of Periodontology　2018/06/01

  47. Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolis. International-presentation

    Katagiri S, Komazaki R, Takahashi H, Maekawa S, Shiba T, Takeuchi Y, Kitajima Y, Ohtsu A, Udagawa S, Sasaki N, Watanabe K, Sato N, Miyasaka N, Eguchi Y, Anzai K, Izumi Y

    The 103rd Annual Meeting of American Academy of Periodontology　2017/09/10

  48. メラトニンによるインスリンを介さない血漿グルコース濃度低下作用－キンギョを用いて

    渡辺数基, 中野真樹, 服部淳彦

    第 41 回日本比較内分泌学会大会及びシンポジウム　2016/12/11

  49. メラトニンによるキンギョの血漿グルコース濃度低下作用

    渡辺数基, 中野真樹, 服部淳彦

    日本動物学会第85回大会　2014/09/13

  50. キンギョにおけるメラトニンの血糖調節作用

    渡辺数基, 中野真樹, 山下 萌, 和田友里子, 服部淳彦

    第３７回 日本比較内分泌学会大会 及びシンポジウム　2012/11/30

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Research Projects 3

  1. 歯周病が加齢性記憶障害に与える影響とメラトニン代謝産物に着目した予防基盤の構築

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows

    Category: Grant-in-Aid for JSPS Fellows

    Institution: Komatsu University

    2022/04 - 2025/03

  2. 歯周病が骨格筋でのglucose uptakeに与える影響とそのメカニズムの解明

    渡辺 数基

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 特別研究員奨励費

    Category: 特別研究員奨励費

    Institution: 東京医科歯科大学

    2020/04/24 - 2022/03/31

  3. 歯周病が骨格筋でのglucose uptakeに与える影響とそのメカニズムの解明 Competitive

    渡辺 数基, 渡辺 数基

    Offer Organization: 文部科学省/日本学術振興会

    Category: 特別研究員奨励費

    2020 - 2021

Teaching Experience 6

  1. 解剖生理学実習　公立小松大学保健医療学部

  2. 卒業研究I・II　公立小松大学保健医療学部 臨床工学科

  3. 講義と実習のバイオサイエンス　東京医科歯科大学教養部生物学

  4. グローバル教養総合講座（GKSK）　Tokyo Medical and Dental University

  5. サイエンスPBL入門　東京医科歯科大学統合教育機構教養教育部門

  6. サイエンスPBL　東京医科歯科大学歯学部歯学科

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