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Shinichiro Osawa

Section

Tohoku University Hospital

Job title

Senior Assistant Professor

Degree

researchmap

https://researchmap.jp/handtalk

J-GLOBAL ID

201101057098407209

Profile

専門：（臨床）てんかん外科脳卒中脳血管内治療
（研究）オプトジェネティクス電気神経生理学脳機能

趣味は囲碁で、いつか研究テーマにしてみたいと思っています。

Research History 14

2018/04 - Present

東北大学大学院　医学系研究科神経外科学分野　助教
2017/04 - 2018/03

東北大学病院　高度救命救急センター　助教
2015/04 - 2017/03

八戸市立市民病院　脳神経外科
2014/04 - 2015/03

広南病院　脳神経外科
2013/04 - 2014/03

仙台医療センター　脳神経外科
2012/10 - 2013/03

Tohoku University hospital　University Hospital Neurosurgery
2009/04 - 2013/03

東北大学医学部脳神経外科　大学院生博士課程（指導・岩崎真樹）
2012/04 - 2012/09

大崎市民病院　脳神経外科
2012/01 - 2012/03

仙台医療センター　脳神経外科
2009/12 - 2011/12

東北大学大学院医学系研究科　神経外科学分野　大学院博士課程
2009/03 - 2009/11

さいたま赤十字病院　脳神経外科
2008/10 - 2009/02

東北大学病院　脳神経外科
2008/04 - 2008/09

広南病院　脳神経外科
2006/04 - 2008/03

十和田市立中央病院　初期研修医

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Education 3

東北大学大学院　医学系研究科　博士課程

2009/04 - 2013/03
Tohoku University　Faculty of Medicine　School of Medicine

- 2006/03
宮城県立気仙沼高等学校　普通科

- 1998/03

Committee Memberships 2

日本てんかん学会　評議員

2017/08 - Present
八戸市立市民病院　臨床研修センター委員

2016/01 - 2017/03

Professional Memberships 3

日本てんかん学会
臨床神経生理学会
日本脳神経外科学会

Research Interests 9

disaster medicine
neurological emergency
stroke
endovascular neurosurgery
包括脳ネットワーク
Functional brain mapping
optogenetics
neurosurgery
epilepsy

Research Areas 4

Life sciences / Neurosurgery / epilepsy
Life sciences / Clinical pharmacy / optogenetics
Life sciences / Physiology / optogenetics
Life sciences / Neuroscience - general / optogenetics

Awards 6

Oral Presentation Award

2021/01　The 44th Annual Meeting of Epilepsy Surgery Society of Japan　Surgical indication and treatment strategy for the patients with epileptic foci in sensory-motor cortex
JES UCB & Otsuka Sponcered Award

2018　Japan Epilepsy Society
The Japanese Society for Kampo Medicine and Neurological Surgery President's award

2016/12　The Japanese Society for Kampo Medicine and Neurological Surgery　Safety and efficacy of Keishi-Bukuryo-Gan in the patients of spontaneous intracerebral hemorrhage within acute period
JES UCB & Otsuka Sponcered Award

2016　Japan Epilepsy Society
Juhn and Mary Wada Prize

2015/10　Japan Epilepsy Society　Optogenetically Induced Seizure and the Longitudinal Hippocampal Network Dynamics
鈴木二郎賞

2013/10

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Papers 159

Complete Corpus Callosotomy Brings Worthwhile Seizure Reduction in Both Pediatric and Adult Patients. International-journal

Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

Neurosurgery　96　(2)　410-415　2024/07/02

DOI： 10.1227/neu.0000000000003092 　

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BACKGROUND AND OBJECTIVES: The influence of the age at which complete corpus callosotomy (CC) surgery is performed on seizure outcomes remains unclear. This study aimed to evaluate the age-dependent aspects of long-term seizure outcomes after complete CC. METHODS: We reviewed 41 patients who underwent one-stage complete CC. Seizure outcomes were analyzed for age at epilepsy onset and at complete CC, focal MRI abnormality, and etiology. RESULTS: The median age was 7 months at epilepsy onset and 93 months at complete CC. The median follow-up duration was 67 months. Sixteen patients had focal MRI lesions and 4 had only general atrophy. Etiology was identified in 20 patients. For overall seizure outcomes (N = 41), complete seizure freedom was achieved in 5 patients, excellent seizure reduction (>80%) in 11, good (50%-80%) in 5, and poor (<50%) in 20. Freedom was correlated with younger age at complete CC and unknown etiology (P ≤ .05). Freedom was only achieved in patients aged younger than 7 years. Worthwhile (≥50%, freedom, excellent, and good) and not worthwhile (<50%, poor) overall seizure reduction showed no statistical difference in age at complete CC. No related factor was found for worthwhile overall seizure reduction. For drop attack outcomes (N = 31), freedom was achieved in 22 cases, excellent in 5, and poor in 4. Freedom was correlated with younger age at complete CC (P < .05) although freedom was achieved in 4 of 7 patients older than 20 years. Age at complete CC showed no statistical difference between worthwhile (≥50%) and not worthwhile (<50%) drop attack reduction. Worthwhile drop attack reduction was correlated with unknown etiology (P < .05). Complications were mild and transient. CONCLUSION: Complete CC is an excellent surgical option based on favorable seizure outcomes and acceptable complications in our present study.
Super-selective injection of propofol into the intracranial arteries enables Patient's self-evaluation of expected neurological deficit. International-journal

Shin-Ichiro Osawa, Kyoko Suzuki, Kazushi Ukishiro, Kazuo Kakinuma, Makoto Ishida, Kuniyasu Niizuma, Yoshiteru Shimoda, Hana Kikuchi, Ryuzaburo Kochi, Kazutaka Jin, Yasushi Matsumoto, Mitsugu Uematsu, Nobukazu Nakasato, Hidenori Endo, Teiji Tominaga

Cortex; a journal devoted to the study of the nervous system and behavior　176　209-220　2024/05/19

DOI： 10.1016/j.cortex.2024.04.016 　

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INTRODUCTION: It is hard to realize the extent of the expected postoperative neurological deficit for patients themselves. The provision of appropriate information can contribute not only to examining surgical indications but also to filling the gap between patient and expert expectations. We hypothesized that propofol infusion into the intracranial arteries (ssWada) could induce focal neurological symptoms with preserved wakefulness, enabling the patients to evaluate the postsurgical risk subjectively. METHODS: Presurgical evaluation using ssWada was performed in 28 patients with drug-resistant epilepsy. Based on anatomical knowledge, propofol was super-selectively infused into the intracranial arteries including the M1, M2, and M3 segments of the middle cerebral artery (MCA), A2 segment of the anterior cerebral artery, and P2 segment of the posterior cerebral artery to evaluate the neurological and cognitive symptoms. We retrospectively analyzed a total of 107 infusion trials, including their target vessels, and elicited symptoms of motor weakness, sensory disturbance, language, unilateral hemispatial neglect (UHN), and hemianopsia. We evaluated preserved wakefulness which enabled subjective evaluations of the symptoms and comparison of the subjective experience to the objective findings, besides adverse effects during the procedure. RESULTS: Preserved wakefulness was found in 97.2% of all trials. Changes in neurological symptoms were positively evaluated for motor weakness in 51.4%, sensory disturbance in 5.6%, language in 48.6%, UHN in 22.4%, and hemianopsia in 32.7%. Six trials elicited seizures. Multivariate analysis showed significant correlations between symptom and infusion site of language and left side, language and MCA branches, motor weakness and A2 or M2 superior division, and hemianopsia and P2. Transient adverse effect was observed in 8 cases with 12 infusion trials (11.2 %). CONCLUSION: The ssWada could elicit focal neurological symptoms with preserved wakefulness. The methodology enables specific evaluation of risk for cortical resection and subjective evaluation of the expected outcome by the patients.
Assessment of language lateralization in epilepsy patients using the super-selective Wada test. International-journal

Kazuo Kakinuma, Shin-Ichiro Osawa, Kazuto Katsuse, Hiroaki Hosokawa, Kazushi Ukishiro, Kazutaka Jin, Kuniyasu Niizuma, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Acta neurochirurgica　166　(1)　77-77　2024/02/10

DOI： 10.1007/s00701-024-05957-8 　

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BACKGROUND: The classical Wada test (cWada), performed by injecting a short-acting anesthetic through the intracarotid route, helps determine language dominance. In the cWada, adverse effects are observed in 10-30% of trials, hindering accurate assessments. In this study, we assessed the effectiveness of the super-selective Wada test (ssWada), a more selective approach for anesthetic infusion into the middle cerebral artery (MCA). METHODS: We retrospectively examined the data of 17 patients with epilepsy who underwent ssWada via anesthetic injection into one M1 segment of the MCA and at least one contralateral trial. RESULTS: The ssWada identified 12 patients with left language dominance, 3 with right language dominance, and 2 with bilateral language distribution. Nine trials on the language dominant side resulted in global aphasia for patients with left- or right language dominance. Of the 13 trials conducted on the non-dominant language side, 12 revealed intact language function and one resulted in confusion. Among these, the outcomes of global aphasia or no language impairment were confirmed in the contralateral trials. Among the 22 trials of unilateral M1 injections in patients with unilateral language dominance, 21 (95.5%) showed either global aphasia or no language impairment, indicating language dominance. CONCLUSIONS: The ssWada yields clear results, with a high rate of over 90% in determining the language dominant hemisphere with few side effects.
Bilateral and asymmetrical localization of language function identified by the superselective infusion of propofol in an epilepsy patient with a mild malformation of cortical development: illustrative case. International-journal

Mayuko Otomo, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Hiroyoshi Suzuki, Kuniyasu Niizuma, Norio Narita, Nobukazu Nakasato, Teiji Tominaga

Journal of neurosurgery. Case lessons　6　(26)　2023/12/25

DOI： 10.3171/CASE23451 　

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BACKGROUND: Atypical localization of language function can result in unexpected postsurgical deficits after cortical resection, but it is difficult to predict the risk in the presurgical evaluation. The authors experienced a rare case of the bilateral and independent existence of different components of language function identified by segmented evaluation of anatomical anterior and posterior language areas using the superselective infusion of propofol. OBSERVATIONS: A 32-year-old right-handed female presented with drug-resistant epilepsy. Comprehensive epilepsy evaluation suggested that the epileptic foci involved the whole left frontal lobe but provided less evidence of structural abnormality. To estimate the extent of functional deterioration likely to be caused by an extended left frontal lobectomy, the authors evaluated segmented cortical function in the ipsi- and contralateral hemispheres by the superselective infusion of propofol into the branches of the intracranial artery. The results revealed bilateral and asymmetrical localization of language function because the patient presented with different components of aphasia in each hemisphere. Based on the authors' assessment of her functional tolerance, an extended left frontal lobectomy was performed and resulted in neurological deficits within the anticipated range. LESSONS: An accurate understanding of the correlations between vascular and functional anatomy and the highly specific evaluation of language function provides more advanced presurgical assessment, allowing more tailored planning of cortical resection.
Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy International-journal

Ryuzaburo Kochi, Shin-ichiro Osawa, Kazutaka Jin, Makoto Ishida, Akitake Kanno, Masaki Iwasaki, Kyoko Suzuki, Ryuta Kawashima, Teiji Tominaga, Nobukazu Nakasato

Clinical Neurophysiology　156　69-75　2023/10
Publisher: Elsevier BV
DOI： 10.1016/j.clinph.2023.09.010 　

ISSN： 1388-2457

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OBJECTIVE: To clarify whether preoperative language magnetoencephalography (MEG) predicts postoperative verbal memory (VM) changes in left mesial temporal lobe epilepsy (LMTLE). METHODS: We reviewed 18 right-handed patients with LMTLE who underwent anterior temporal lobectomy or selective amygdala hippocampectomy, 12 with (HS+) and 6 without hippocampal sclerosis (HS-). Patients underwent neuropsychological assessment before and after surgery. MEG was measured with an auditory verbal learning task in patients preoperatively and in 15 right-handed controls. Dynamic statistical parametric mapping (dSPM) was used for source imaging of task-related activity. Language laterality index (LI) was calculated by z-score of dSPM in language-related regions. LI in the region of HS+ and HS- was compared to controls. The correlation between LI and postoperative VM change was assessed in HS+ and HS-. RESULTS: Preoperative LI in supramarginal gyrus showed greater right-shifted lateralization in both HS+ and HS- than in controls. Right-shifted LI in supramarginal gyrus was correlated with postoperative VM increase in HS+ (p = 0.019), but not in HS-. CONCLUSIONS: Right-shifted language lateralization in dSPM of MEG signals may predict favorable VM outcome in HS+ of LMTLE. SIGNIFICANCE: Findings warrant further investigation of the relation between regional language laterality index and postoperative verbal memory changes.
Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke. International-journal

Kuniyasu Niizuma, Shin-Ichiro Osawa, Hidenori Endo, Shin-Ichi Izumi, Kota Ataka, Akihiro Hirakawa, Masao Iwano, Teiji Tominaga

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism　43　(12)　271678X231202594-2039　2023/09/27

DOI： 10.1177/0271678X231202594 　

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Effective treatments for stroke after the acute phase remain elusive. Muse cells are endogenous, pluripotent, immune-privileged stem cells capable of selectively homing to damaged tissue after intravenous injection and replacing damaged/lost cells via differentiation. This randomized, double-blind, placebo-controlled trial enrolled ischemic stroke patients with modified Rankin Scale (mRS) ≥3. Randomized patients received a single intravenous injection of an allogenic Muse cell-based product, CL2020 (n = 25), or placebo (n = 10), without immunosuppressant, 14-28 days after stroke onset. Safety (primary endpoint: week 12) and efficacy (mRS, other stroke-specific measures) were assessed up to 52 weeks. Key efficacy endpoint was response rate (percentage of patients with mRS ≤2 at week 12). To week 12, 96% of patients in the CL2020 group experienced adverse events and 28% experienced adverse reactions (including one Grade 4 status epilepticus), compared with 100% and 10%, respectively, in the placebo group. Response rate was 40.0% (95% CI, 21.1-61.3) in the CL2020 group and 10.0% (0.3-44.5) in the placebo group; the lower CI in the CL2020 group exceeded the preset efficacy threshold (8.7% from registry data). This randomized placebo-controlled trial demonstrated CL2020 is a possible effective treatment for subacute ischemic stroke.Registry information: JAPIC Clinical Trials Information site (JapicCTI-184103, URL: https://www.clinicaltrials.jp/cti-user/trial/ShowDirect.jsp?japicId=JapicCTI-184103).
Visualization of the lenticulostriate arteries, long insular arteries, and long medullary arteries on intra-arterial computed tomography angiography with ultrahigh resolution in patients with glioma. International-journal

Yoshinari Osada, Masayuki Kanamori, Shin-Ichiro Osawa, Shingo Kayano, Hiroki Uchida, Yoshiteru Shimoda, Shunji Mugikura, Teiji Tominaga, Hidenori Endo

Acta neurochirurgica　165　(12)　4213-4219　2023/09/20

DOI： 10.1007/s00701-023-05794-1 　

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PURPOSE: The anatomical association between the lesion and the perforating arteries supplying the pyramidal tract in insulo-opercular glioma resection should be evaluated. This study reported a novel method combining the intra-arterial administration of contrast medium and ultrahigh-resolution computed tomography angiography (UHR-IA-CTA) for visualizing the lenticulostriate arteries (LSAs), long insular arteries (LIAs), and long medullary arteries (LMAs) that supply the pyramidal tract in two patients with insulo-opercular glioma. METHODS: This method was performed by introducing a catheter to the cervical segment of the internal carotid artery. The infusion rate was set at 3 mL/s for 3 s, and the delay time from injection to scanning was determined based on the time-to-peak on angiography. On 2- and 20-mm-thick UHR-IA-CTA slab images and fusion with magnetic resonance images, the anatomical associations between the perforating arteries and the tumor and pyramidal tract were evaluated. RESULTS: This novel method clearly showed the relationship between the perforators that supply the pyramidal tract and tumor. It showed that LIAs and LMAs were far from the lesion but that the proximal LSAs were involved in both cases. Based on these results, subtotal resection was achieved without complications caused by injury of perforators. CONCLUSION: UHR-IA-CTA can be used to visualize the LSAs, LIAs, and LMAs clearly and provide useful preoperative information for insulo-opercular glioma resection.
Causal involvement of medial inferior frontal gyrus of non-dominant hemisphere in higher order auditory perception: A single case study. International-journal

Shin-Ichiro Osawa, Kyoko Suzuki, Eishi Asano, Kazushi Ukishiro, Dai Agari, Kazuo Kakinuma, Ryuzaburo Kochi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Cortex; a journal devoted to the study of the nervous system and behavior　163　57-65　2023/03/29

DOI： 10.1016/j.cortex.2023.02.007 　

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The medial side of the operculum is invisible from the lateral surface of cerebral cortex, and its functions remain largely unexplored using direct evidence. Non-invasive and invasive studies have proved functions on peri-sylvian area including the inferior frontal gyrus (IFG) and superior temporal gyrus within the language-dominant hemisphere for semantic processing during verbal communication. However, within the non-dominant hemisphere, there was less evidence of its functions except for pitch or prosody processing. Here we add direct evidence for the functions of the non-dominant hemisphere, the causal involvement of the medial IFG for subjective auditory perception, which is affected by the context of the condition, regarded as a contribution in higher order auditory perception. The phenomenon was clearly distinguished from absolute and invariant pitch perception which is regarded as lower order auditory perception. Electrical stimulation of the medial surface of pars triangularis of IFG in non-dominant hemisphere via depth electrode in an epilepsy patient rapidly and reproducibly elicited perception of pitch changes of auditory input. Pitches were perceived as either higher or lower than those given without stimulation and there was no selectivity for sound type. The patient perceived sounds as higher when she had greater control over the situation when her eyes were open and there were self-cues, and as lower when her eyes were closed and there were investigator-cues. Time-frequency analysis of electrocorticography signals during auditory naming demonstrated medial IFG activation, characterized by low-gamma band augmentation during her own vocal response. The overall evidence provides a neural substrate for altered perception of other vocal tones according to the condition context.
Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation. International-journal

Daigo Terutsuki, Hayato Yoroizuka, Shin-Ichiro Osawa, Yuka Ogihara, Hiroya Abe, Atsuhiro Nakagawa, Masaki Iwasaki, Matsuhiko Nishizawa

Advanced healthcare materials　11　(23)　e2201627　2022/12

DOI： 10.1002/adhm.202201627 　

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An intrinsically soft organic electrode consisting of poly(3,4-ethylenedioxythiophene)-modified polyurethane (PEDOT-PU) is embedded into a bilayer film of polyvinyl alcohol (PVA) hydrogels for developing a self-closing cuff electrode for neuromodulation. The curled form of the PVA hydrogel is prepared by releasing internal stress in the bilayer structure. The inner diameter of the cuff electrode is set to less than 2 mm for immobilization to the vagus nerve (VN) of humans and pigs. The stability of the immobilization is examined, while the pressure applied to a nerve bundle is at a harmless level (≈200 Pa). Since the electrode is totally organic, MRI measurements can be conducted without image artifacts. The large electric capacitance of the PEDOT-PU (≈27 mF cm-2 ) ensures a safe stimulation of living tissues without Faradaic reactions. The practical performance of the cuff electrode for VN stimulation is demonstrated by observation of bradycardia induction in a pig.
Determination of language areas in patients with epilepsy using the super-selective Wada test. International-journal

Kazuo Kakinuma, Shin-Ichiro Osawa, Hiroaki Hosokawa, Marie Oyafuso, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Takafumi Sato, Mika Sakamoto, Kuniyasu Niizuma, Teiji Tominaga, Nobukazu Nakasato, Kyoko Suzuki

IBRO neuroscience reports　13　156-163　2022/12

DOI： 10.1016/j.ibneur.2022.08.002 　

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The Wada test is the gold standard for determining language-dominant hemisphere. However, the precise determination of language areas in each patient requires more invasive methods, such as electrocortical stimulation. Some studies have reported the use of anesthetic injection into selective cerebral arteries to predict postoperative function. To assess the function of the anterior and posterior language areas separately, we developed an advanced test named the "super-selective Wada test" (ssWada). The ssWada procedure is as follows: an endovascular neurosurgeon identifies the arterial branches of the middle cerebral artery (MCA) perfusing the anterior language area of the inferior frontal gyrus and the posterior language area of the posterior part of the superior temporal gyrus using angiography. Behavioral neurologists assess language symptoms before and after propofol administration using a microcatheter tip in the selected arterial branch. From 30 serial patients with epilepsy who underwent ssWada test at Tohoku University Hospital, we retrospectively reviewed patients in whom multiple areas in the bilateral MCA region was examined. Eight cases were identified in this study. All eight cases had been considered for resection of the area overlapping the classical language area. Three of the eight cases were left-dominant, and the within-hemisphere distribution was also considered typical. One case was determined to be left-dominant but atypical in the intra-hemispheric functional distribution. Two cases were right-dominant, and the intra-hemispheric functional distribution was considered a mirror image of the typical pattern. The remaining two cases were considered atypical, not only in terms of bilateral language function, but also in terms of anterior-posterior functional distribution. This case series demonstrates the potential utility of ssWada in revealing separate function of the anterior and posterior language areas. The ssWada allows simulation of local surgical brain resection and detailed investigation of language function, which potentially contributes to planning the resection area. Although indications for ssWada are quite limited, it could play a complementary role to noninvasive testing because it provides information related to resection using a different approach.
A Super-selective Wada Test Successfully Detected an Artery That Supplied Broca's Area in a Case of Left Frontal Lobe Glioblastoma: Technical Case Report.

Shota Yamashita, Ryuta Saito, Shin-Ichiro Osawa, Kuniyasu Niizuma, Kazushi Ukishiro, Masayuki Kanamori, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga

Neurologia medico-chirurgica　61　(11)　661-666　2021/08/26

DOI： 10.2176/nmc.tn.2021-0054 　

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In cases of malignant gliomas located at language eloquent area, it is often difficult to preoperatively detect those area with functional MRI. Awake surgery is often used to spare the language eloquent area during surgery for such tumors; it is not available for a patient whose intracranial pressure is elevated due to the malignant tumor. The Wada test involves infusing anesthetic agents into the internal carotid artery to determine language dominancy before surgery for epilepsy or brain tumor. The super-selective Wada test is a technique to detect more detailed functional localization by infusing anesthetics into far distal middle cerebral artery branches. We present a 37-year-old man suffering from a left frontal lobe glioblastoma, in whom detection of an artery supplying Broca's area was attempted by a super-selective Wada test. The super-selective Wada test successfully detected the branch of middle cerebral artery supplying Broca's area. Total resection of the contrast-enhancing area was achieved without damaging the artery supplying Broca's area without any neurological sequelae. This is the first report describing the usefulness of the super-selective Wada test in glioblastoma treatment. Our findings suggest that the super-selective Wada test is a powerful and useful means to distinguish the artery that supplies the language area from the tumor feeding artery in cases of tumors in the language eloquent area.
Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners. International-journal

Hirotaka Iwaki, Masaki Sonoda, Shin-Ichiro Osawa, Brian H Silverstein, Takumi Mitsuhashi, Kazushi Ukishiro, Yutaro Takayama, Toshimune Kambara, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

Scientific reports　11　(1)　5257-5257　2021/03/04

DOI： 10.1038/s41598-021-84610-1 　

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The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.
Application of Optogenetics in Epilepsy Research. International-journal

Shin-Ichiro Osawa, Teiji Tominaga

Advances in experimental medicine and biology　1293　557-562　2021

DOI： 10.1007/978-981-15-8763-4_39 　

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Epilepsy is a disease characterized by seizures arising from paroxysmal and self-limited hypersynchrony of neurons. However, the mechanism by which the normal brain develops epilepsy, which involves a chronic process of structural and morphological changes known as epileptogenesis, is not fully understood. Optogenetics involves the use of genetic engineering and optics to monitor or control nerve cell activity. Compared to classical electrophysiological experiments, the application of optogenetics in epilepsy research has many advantages because it allows selective photic stimulation of cell types and electrical observation without introducing artifacts.
Multimodal Functional Analysis Platform: 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits. International-journal

Hajime Mushiake, Tomokazu Ohshiro, Shin-Ichiro Osawa, Ryosuke Hosaka, Norihiro Katayama, Tetsu Tanaka, Hiromu Yawo, Makoto Osanai

Advances in experimental medicine and biology　1293　501-509　2021

DOI： 10.1007/978-981-15-8763-4_34 　

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To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.
Totally transparent hydrogel-based subdural electrode with patterned salt bridge. International-journal

Ayaka Nishimura, Ryota Suwabe, Yuka Ogihara, Shotaro Yoshida, Hiroya Abe, Shin-Ichiro Osawa, Atsuhiro Nakagawa, Teiji Tominaga, Matsuhiko Nishizawa

Biomedical microdevices　22　(3)　57-57　2020/08/22

DOI： 10.1007/s10544-020-00517-0 　

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A totally transparent subdural electrode was developed by embedding a conductive poly (vinyl alcohol) (PVA)-filled microchannel made of poly(dimethylsiloxane) (PDMS) into an another PVA hydrogel substrate. Tight bonding between the PVA substrate and the PDMS microchannel (salt bridge) was achieved by mechanical interlocking utilizing the microprotrusions formed on the microchannel. This simple method of bonding without the use of any additives such as silane molecules or nanofibers is very suitable for constructing biomedical devices. The salt bridge electrode (total thickness, ca. 1.5 mm) was sufficiently soft, and showed superior shape conformability that makes it an excellent choice as a subdural electrode used on the brain surface. In vivo measurement proved that the salt bridge electrode makes close contact to the exposed porcine brain and can record brain wave signals of frequencies 1 ~ 15 Hz. In addition, the high transparency of the electrode provided a clear view of the brain surface that would assist the effective surgical operation and optogenetic research.
Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface. International-journal Peer-reviewed

Shuntaro Oribe, Shotaro Yoshida, Shinya Kusama, Shin-Ichiro Osawa, Atsuhiro Nakagawa, Masaki Iwasaki, Teiji Tominaga, Matsuhiko Nishizawa

Scientific reports　9　(1)　13379-13379　2019/09/16

DOI： 10.1038/s41598-019-49772-z 　

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A totally soft organic subdural electrode has been developed by embedding an array of poly(3,4-ethylenedioxythiophene)-modified carbon fabric (PEDOT-CF) into the polyvinyl alcohol (PVA) hydrogel substrate. The mesh structure of the stretchable PEDOT-CF allowed stable structural integration with the PVA substrate. The electrode performance for monitoring electrocorticography (ECoG) was evaluated in saline solution, on ex vivo brains, and in vivo animal experiments using rats and porcines. It was demonstrated that the large double-layer capacitance of the PEDOT-CF brings low impedance at the frequency of brain wave including epileptic seizures, and PVA hydrogel substrate minimized the contact impedance on the brain. The most important unique feature of the hydrogel-based ECoG electrode was its shape conformability to enable tight adhesion even to curved, grooved surface of brains by just being placed. In addition, since the hydrogel-based electrode is totally organic, the simultaneous ECoG-fMRI measurements could be conducted without image artifacts, avoiding problems induced by conventional metallic electrodes.
[Safety and Efficacy of Keishi-Bukuryo-Gan in Patients with Spontaneous Intracerebral Hemorrhage during the Acute Period:CT Image-Based Analysis of the Clearance of Hematoma]. Peer-reviewed

Shin-Ichiro Osawa, Hidenori Endo, Tsuyoshi Kawamura, Teiji Tominaga

No shinkei geka. Neurological surgery　46　(9)　763-770　2018/09

DOI： 10.11477/mf.1436203810 　

ISSN： 0301-2603

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BACKGROUND: Keishi-Bukuryo-Gan(KBG)is a traditional Japanese(Kampo)formula used to improve microcirculation and a congestive condition called "Oketsu". KBG is also used to prevent the development of atherosclerosis. Many patients with intracerebral hemorrhage(ICH)have comorbid diseases related to atherosclerosis;thus, KBG may be a treatment option for ICH. OBJECTIVE: The aim of this study was to investigate whether the administration of KBG in patients with ICH during the acute phase affects the course of absorption of ICH, detected using computed tomography(CT). MATERIAL AND METHODS: We identified 308 patients with ICH who were diagnosed and treated at our institution from April 2013 to June 2016. Among them, 53 patients were chosen based on the accessibility of CT images, patient background, and past history. The volume and CT value of the hematoma were analyzed at admission, one week(six to eight days)after admission, and two weeks(thirteen to sixteen days)after admission. RESULTS: There were no significant differences between KBG and non-KBG patients in terms of the background parameters, hematoma volume, or CT value at admission. However, there were significant differences in both the volume reduction ratio(non-KBG=64.3±8.4%, KBG=48.5±14.5%, p=0.03)and CT value(non-KBG=48.5±4.6HU, KBG=44.0±7.0HU, p=0.04)two weeks after admission. CONCLUSION: Significant improvement in the absorption of ICH was observed in KBG patients. To our knowledge, this is the first report that shows the facilitative effect of KBG on intracranial hematoma clearance during the acute phase.
Embolization of ruptured arteriovenous malformations in the cerebellopontine angle cistern. International-journal Peer-reviewed

Hidenori Endo, Shin-Ichiro Osawa, Yasushi Matsumoto, Toshiki Endo, Kenichi Sato, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga

Neurosurgical review　41　(1)　173-182　2018/01
Publisher: Springer Verlag
DOI： 10.1007/s10143-017-0832-1 　

ISSN： 1437-2320 0344-5607
Clinical profiles for seizure remission and developmental gains after total corpus callosotomy. International-journal Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Naomi Hino-Fukuyo, Shin-ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Brain & development　38　(1)　47-53　2016/01

DOI： 10.1016/j.braindev.2015.04.010 　

ISSN： 0387-7604

eISSN： 1872-7131
Occult dual pathology in mesial temporal lobe epilepsy. International-journal Peer-reviewed

Shin-Ichiro Osawa, Masaki Iwasaki, Hiroyoshi Suzuki, Nobukazu Nakasato, Teiji Tominaga

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology　36　(9)　1743-5　2015/09

DOI： 10.1007/s10072-015-2268-0 　

ISSN： 1590-1874

eISSN： 1590-3478
Increase in the number of patients with seizures following the Great East-Japan Earthquake. International-journal Peer-reviewed

Ichiyo Shibahara, Shin-Ichiro Osawa, Hiroyuki Kon, Takahiro Morita, Nobukazu Nakasato, Teiji Tominaga, Norio Narita

Epilepsia　54　(4)　e49-52-52　2013/04

DOI： 10.1111/epi.12070 　

ISSN： 0013-9580

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In the afternoon of March 11, 2011, Kesennuma City was hit by the Great East-Japan Earthquake and a devastating tsunami. The purpose of this retrospective study is to document possible changes in the number of patients with distinct neurologic diseases seeking treatment following this disaster. Because of Kesennuma's unique geographical location, the city was isolated by the disaster, allowing for a study with relatively limited population selection bias. Patients admitted for neurologic emergencies from January 14 to May 5 in 2011 (n = 117) were compared with patients in the corresponding 16-week periods in 2008-2010 (n = 323). The number of patients with unprovoked seizures was significantly higher during the 8-week period after the earthquake (n = 13) than during the same periods in 2008 (n = 6), 2009 (n = 3), and 2010 (no patients) (p = 0.0062). In contrast, the number of patients treated for other neurologic diseases such as stroke, trauma, and tumors remained unchanged. To our knowledge, this is the first report of an increase in the number of patients with seizures following a life-threatening natural disaster. We suggest that stress associated with life-threatening situations may enhance seizure generation.
Optogenetically induced seizure and the longitudinal hippocampal network dynamics. International-journal Peer-reviewed

Shin-Ichiro Osawa, Masaki Iwasaki, Ryosuke Hosaka, Yoshiya Matsuzaka, Hiroshi Tomita, Toru Ishizuka, Eriko Sugano, Eiichi Okumura, Hiromu Yawo, Nobukazu Nakasato, Teiji Tominaga, Hajime Mushiake

PloS one　8　(4)　e60928　2013

DOI： 10.1371/journal.pone.0060928 　

ISSN： 1932-6203
A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm. International-journal Peer-reviewed

Shin-Ichiro Osawa, Atsushi Saito, Hiroaki Shimizu, Takenori Ogawa, Mika Watanabe, Teiji Tominaga

Journal of vascular surgery　55　(1)　230-3　2012/01

DOI： 10.1016/j.jvs.2011.06.108 　

ISSN： 0741-5214
Hypophysitis presenting with atypical rapid deterioration: with special reference to immunoglobulin G4-related disease-case report-. Peer-reviewed

Shinichiro Osawa, Yoshikazu Ogawa, Mika Watanabe, Teiji Tominaga

Neurologia medico-chirurgica　49　(12)　622-5　2009/12

DOI： 10.2176/nmc.49.622 　

ISSN： 0470-8105

eISSN： 1349-8029
Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT. Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Hiroshi Watabe, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shigeo Kinomura, Shinichiro Osawa, Yoshimi Onishi, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

Annals of nuclear medicine　20　(9)　605-13　2006/11

DOI： 10.1007/BF02984658 　

ISSN： 0914-7187
Clinical profile of idiopathic normal pressure hydrocephalus with reduced myocardial sympathetic nerve function

Shiho Matsubara, Shigenori Kanno, Toru Baba, Yoshiyuki Nishio, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Hayato Odagiri, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Kyoko Suzuki

Parkinsonism & Related Disorders　108213-108213　2026/01
Publisher: Elsevier BV
DOI： 10.1016/j.parkreldis.2026.108213 　

ISSN： 1353-8020
Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery. International-journal

Keisuke Hatano, Naoto Kuroda, Hiroshi Uda, Kazuki Sakakura, Michael J Cools, Aimee F Luat, Shin-Ichiro Osawa, Hitoshi Nemoto, Kazushi Ukishiro, Hidenori Endo, Nobukazu Nakasato, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Eishi Asano

medRxiv : the preprint server for health sciences　2025/12/19

DOI： 10.64898/2025.12.17.25342490 　

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Although epilepsy surgery studies have proposed intracranial EEG-derived biomarkers for localizing seizure onset and anticipating postoperative outcomes, evaluation has often been limited to derivation cohorts using internal cross-validation. An influential notion holds that neurons distributed within the seizure onset zone (SOZ) frequently generate high-frequency activity (HFA) and that resection of such sites is associated with favorable postoperative seizure control. However, the extent to which these prediction models generalize to independent patient populations-and across diverse underlying etiologies-has remained largely untested. In this international, multi-center study of drug-resistant focal epilepsy, we retrospectively quantified HFA occurrence rates together with a comprehensive set of morphological features and integrated these metrics into predictive models for SOZ localization and postoperative seizure outcome. We then assessed model performance in fully independent datasets-a temporal external cohort and two geographical external cohorts-each entirely separate from the derivation cohort. In total, 5,142,891 HFA events observed across 22,939 electrodes from 233 patients were analyzed. Among the model inputs, HFA rate, spectral entropy, and power emerged as the most influential features for accurate SOZ classification. The model reliably identified clinician-defined SOZ sites across centers, achieving areas under the curve (AUCs) of up to 0.85 in the derivation cohort using 10-fold cross-validation, up to 0.86 in the temporal external cohort, and up to 0.75 in the geographical external cohorts. Within the derivation cohort, the model predicted postoperative seizure freedom with an AUC of up to 0.70. In contrast, postoperative seizure outcomes could not be predicted reliably across the external cohorts. Specifically, among external-cohort patients with MRI non-lesional epilepsy, postoperative seizure freedom was predicted with an AUC of up to 0.73, whereas performance declined to 0.46 or below among patients with encephalomalacia, an etiology characterized by chronic parenchymal damage and marked neuronal loss. Together, integration of HFA occurrence rates with morphological features yields an SOZ-localization biomarker with cross-center generalizability, whereas postoperative outcome prediction remains highly dependent on underlying etiology. Notably, a surgical strategy that prioritizes resection of HFA-involved areas does not appear to be applicable to patients with encephalomalacia and may be ineffective or even counterproductive in this population. A total of 97.86 GB of iEEG data are publicly available to facilitate external validation by the epilepsy surgery research community and the development of improved biomarkers for epileptogenic zone localization.
Preoperative assessment of perforating arteries around amygdala glioblastoma using intra-arterial CT angiography with ultra-high-resolution CT and MR tractography: a case report. International-journal

Gaku Inoue, Masayuki Kanamori, Shin-Ichiro Osawa, Yoshiteru Shimoda, Kazuki Shimada, Shingo Kayano, Yoshinari Osada, Shota Yamashita, Shunji Mugikura, Hidenori Endo

Acta neurochirurgica　167　(1)　320-320　2025/12/11

DOI： 10.1007/s00701-025-06741-y 　

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Preservation of the perforating arteries (PAs) supplying the pyramidal tract (PT-PAs) is essential during glioblastoma resection. A 60-year-old man presented with sensory aphasia caused by a left medial temporal glioblastoma. To determine the surgical indication and strategy, we assessed the tumor's location and its relationship with the PT-PAs using intra-arterial computed tomography (CT) angiography combined with ultra-high-resolution CT (UHR-IA-CTA), gadolinium-enhanced T1-weighted magnetic resonance imaging, and tractography. Imaging revealed an amygdala glioblastoma without the involvement of PT-PAs. Total tumor resection was achieved without neurological deficits. This case highlights how integrating UHR-IA-CTA can guide surgical planning and enable safe, complete glioblastoma resection.
White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus

Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

Fluids and Barriers of the CNS　22　(1)　2025/10/27
Publisher: Springer Science and Business Media LLC
DOI： 10.1186/s12987-025-00718-w 　

eISSN： 2045-8118
Postsurgical psychogenic non-epileptic seizure: a treatment-related functional neurological disorder

Shin-ichiro Osawa, Maimi Ogawa, Hirotaka Iwaki, Yuko Akitsuki, Mayu Fujikawa, Kazushi Ukishiro, Kazutaka Jin, Atsushi Sakuma, Hiroaki Tomita, Kyoko Suzuki, Nobukazu Nakasato, Hidenori Endo

Journal of Neurology, Neurosurgery & Psychiatry　2025/10/05

DOI： 10.1136/jnnp-2025-336913 　
Water-triggered self-wrapping and immobilization of an all-organic hydrogel-based cuff electrode

Shin-ichiro Osawa, Fumiya Imamura, Natsuki Nozaki, Tenyo Ko, Shuto Osaki, Soichiro Tottori, Atsuhiro Nakagawa, Matsuhiko Nishizawa

Materials Today Bio　2025/10

DOI： 10.1016/j.mtbio.2025.102248 　
Improvement of Functional Brain Mapping Through Selective Anesthesia by the Combination of Super-selective Infusion and Customized Neurocognitive Tests. International-journal

Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Hana Kikuchi, Nobukazu Nakasato, Hidenori Endo

World neurosurgery　124482-124482　2025/09/11

DOI： 10.1016/j.wneu.2025.124482 　
Retrospective interviews reveal unawareness of weakness following reversible hemispheric suppression: An exploratory study using selective anesthesia for functional evaluation. International-journal

Hiroaki Hosokawa, Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Shoko Ota, Erena Kobayashi, Nobuko Kawakami, Marie Oyafuso, Kazushi Ukishiro, Kazutaka Jin, Makoto Ishida, Kuniyasu Niizuma, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Cortex; a journal devoted to the study of the nervous system and behavior　190　146-154　2025/09

DOI： 10.1016/j.cortex.2025.06.015 　

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Unawareness of weakness-defined as an explicit failure to recognize one's own limb paresis after brain damage-has long been considered predominantly linked to right-hemisphere dysfunction, yet its laterality remains controversial. We retrospectively analyzed 86 sessions of Selective Anesthesia for Functional Evaluation (SAFE) conducted in 53 patients with surgical epilepsy. SAFE involves delivering a short-acting anesthetic into a single cortical artery branch, resulting in reversible cortical suppression. Contralateral weakness was defined as a positive Barré sign in the upper limb, corresponding to a Manual Muscle Test score of <3. Following the anesthetic effect, patients were asked whether they had experienced any motor impairment. Explicit unawareness was probed using two standardized questions, followed by a limb-specific inquiry. Interviews were conducted in real-time during 28 infusions and repeated within 30 sec of motor recovery in the remaining 58 sessions. Unawareness occurred in 41 of 52 left-hemisphere infusions (78.8%) and in 26 of 34 right-hemisphere infusions (76.5%). Real-time and immediate post hoc ratings were concordant in 26 of 28 paired assessments (93%). Infusions into the M2-superior division were associated with higher rates of unawareness than those into the M2-inferior division (odds ratio = 2.3, 95% confidence interval: 1.1-5.1). Within this reversible perfusion-suppression model, the frequency of unawareness of weakness was hemispherically balanced, promoting a cautious re-evaluation of the presumed right-hemisphere dominance. SAFE provides a practical tool for isolating transient awareness deficits without structural injury and may help bridge pharmacological and lesion-based approaches to brain-behavior mapping.
Localization of the Epileptogenic Zone Using Neural Spatial Volatility in Epilepsy Surgery. International-journal

Naoto Kuroda, Hiroshi Uda, Keiki Inoue, Yu Kitazawa, Shin-Ichiro Osawa, Hitoshi Nemoto, Makoto Ishida, Kazushi Ukishiro, Aimee F Luat, Hidenori Endo, Nobukazu Nakasato, Eishi Asano

Neurology　105　(4)　e213906　2025/08/26

DOI： 10.1212/WNL.0000000000213906 　

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BACKGROUND AND OBJECTIVES: Diseased tissues in the human brain frequently exhibit marked alterations in structural and functional properties compared with adjacent, unaffected regions, whereas healthy tissues display intrinsic, milder topographical variability in these properties. We hypothesized that the epileptogenic zone responsible for drug-resistant focal seizures would be characterized by pronounced alterations in electrographic properties relative to adjacent regions. METHODS: This international, multicenter observational study aimed to test this hypothesis by studying patients with drug-resistant focal epilepsy who underwent curative epilepsy surgery following intracranial EEG (iEEG) recording, with at least 1 year of postoperative follow-up. In this study, "neural spatial volatility" was defined as differences in interictal high-frequency electrographic measures compared with adjacent areas. We tested whether greater neural spatial volatility in resected compared to preserved sites predicts postoperative seizure freedom, independently of clinical, neuroimaging, and ictal iEEG data. In addition, we examined whether incorporating neural spatial volatility into an outcome prediction model, based on the standard-care presurgical evaluation, would improve its performance. RESULTS: In a derivation cohort of 140 patients with 14,933 samples of iEEG electrodes (mean age 13.1 years; female 68 [48.6%]; postoperative seizure freedom 98 [70.0%]), greater neural spatial volatility in resected compared with preserved sites was an independent predictor of postoperative seizure freedom. The outcome prediction model considering the neural spatial volatility improved the classification performance, showing the area under the curve up to 0.825 (95% CI 0.747-0.902; p < 1.0 × 10-15). This result was validated in an independent test dataset of 26 patients with 1,626 samples of iEEG electrodes (mean age 25.7 years; female 14 [53.8%]; postoperative seizure freedom 16 [61.5%]) at a different institution, showing the improvement of prediction performance up to 0.819 (95% CI 0.653-0.985; p < 0.0005). DISCUSSION: Despite the limitations of the retrospective study and the relatively small validation cohort, our findings suggest that increased heterogeneity in the mesoscale distribution of interictal high-frequency activity is a distinguishing feature of the epileptogenic zone in drug-resistant focal epilepsy, potentially offering a novel marker for its localization.
Visualization of functional and effective connectivity underlying auditory descriptive naming. International-journal

Yu Kitazawa, Kazuki Sakakura, Hiroshi Uda, Naoto Kuroda, Riyo Ueda, Ethan Firestone, Min-Hee Lee, Jeong-Won Jeong, Masaki Sonoda, Shin-Ichiro Osawa, Kazushi Ukishiro, Makoto Ishida, Kazuo Kakinuma, Shoko Ota, Yutaro Takayama, Keiya Iijima, Toshimune Kambara, Hidenori Endo, Kyoko Suzuki, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　175　2010729-2010729　2025/07

DOI： 10.1016/j.clinph.2025.04.008 　

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OBJECTIVE: We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions. METHODS: We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography. RESULTS: Hearing a wh-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with what, compared to where, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus. CONCLUSIONS: Visualization of directional neural interactions within white matter networks during overt naming is feasible. SIGNIFICANCE: Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.
Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation. International-journal

Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

Journal of neurosurgery　1-8　2025/06/13

DOI： 10.3171/2025.2.JNS242534 　

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OBJECTIVE: The Wada test, an intracarotid amobarbital procedure, is the gold standard for the preoperative evaluation of postoperative memory decline in patients with drug-resistant epilepsy. However, because the anesthetic perfuses the language areas, infusion into the language-dominant hemisphere also causes aphasia. Although it has been noted that aphasia may affect verbal memory scores in the Wada test, the extent of the effects has not been verified. This study aimed to examine the extent to which verbal memory is affected by aphasia induced by selective anesthetization of the proximal middle cerebral artery (M1) area (which does not affect the hippocampus) in patients with drug-resistant epilepsy. METHODS: This single-center retrospective analysis included patients with drug-resistant epilepsy who underwent the Selective Anesthesia for Functional Evaluation (SAFE) as a preoperative evaluation between May 2018 and December 2023. SAFE includes cognitive tasks of equal difficulty administered before and immediately after anesthetic infusion. The preinfusion assessments confirmed the baseline, whereas the postinfusion assessments evaluated brain function under selective anesthesia. The patients were required to memorize 8 words and 8 pictures. After the anesthetic effects subsided, recognition tasks were performed for both words and pictures. The number of words and pictures successfully recognized were counted as verbal and visual memory scores, respectively. Memory scores were compared between the left and right M1 infusions. RESULTS: Of the 180 SAFE trials conducted during the study period, 38 trials (25 left and 13 right M1 infusions) in 29 patients with confirmed left language dominance and propofol infusion into the M1 were included. All left M1 infusions induced aphasia without causing significant disturbances in consciousness that could have interfered with task completion. The results indicated significantly lower verbal memory scores during left M1 infusions than during right M1 infusions, whereas the visual memory scores were comparable. CONCLUSIONS: The verbal memory score was significantly lower after infusion into the M1 of the language-dominant hemisphere than into the nondominant hemisphere, suggesting that aphasia during stimulus encoding may impair verbal memory. Thus, the Wada test with intracarotid anesthetic infusion may not accurately assess memory function due to aphasia. This study highlights the utility of SAFE in reducing aphasic interference in verbal memory, leading to a more accurate evaluation of surgical candidacy in patients with epilepsy.
Serum Lactate–Based Stratification for Seizure Diagnosis in Resource-Limited Neurologic Emergency Settings

Shin-ichiro Osawa, Satoshi Miyata, Kensuke Fujita, Tsuyoshi Kawamura, Ichiro Suzuki, Kensuke Kimura, Toshimi Okushima, Akihide Konn, Hidenori Endo

2025/05/04

DOI： 10.1101/2025.05.01.25326838 　
Perforating artery injury as a critical factor besides cortical dysfunction in motor deficit after peri-rolandic epilepsy surgery. International-journal

Atsuhiko Ninomiya, Shin-Ichiro Osawa, Kyoko Suzuki, Kazuo Kakinuma, Kazushi Ukishiro, Yoshiteru Shimoda, Kazutaka Jin, Mitsugu Uematsu, Shiho Sato, Shunji Mugikura, Hiroyoshi Suzuki, Hajime Miyata, Shingo Kayano, Nobukazu Nakasato, Hidenori Endo

Journal of neurosurgery　142　(6)　1-13　2025/02/14

DOI： 10.3171/2024.10.JNS24878 　

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OBJECTIVE: Surgery for peri-rolandic epilepsy requires appropriate consideration to balance the functional risk of postoperative motor deficit and seizure outcome. Based on voxel-based morphometric analysis, the authors hypothesized that cortical damage and ischemic subcortical damage related to surgery could affect postoperative motor deterioration. METHODS: Sixteen patients with peri-rolandic epilepsy who underwent resective surgery at a single institution were retrospectively investigated. Their imaging findings, postoperative seizure outcomes, and postoperative neurological deteriorations in motor function, as well as duration, were analyzed. Using the standardized MRI data of each case, the authors examined the surgically resected area on high-resolution 3D MR images and the high-intensity area on diffusion-weighted images, which were converted to voxel data. These voxel data were superimposed on a standard brain image for neuroimaging assessment. Postoperative motor deterioration of the orofacial region, upper limb, or lower limb was noted as no, transient, or permanent deterioration and analyzed in relation to the surgically resected area and subcortical damage. Univariate analysis of the clinical factors was conducted between cases with permanent upper- and/or lower-limb motor deterioration and those with no or transient deterioration. RESULTS: The mean follow-up period was 28 months. Ten patients (62.5%) achieved Engel class I. Fourteen patients (87.5%) experienced postoperative motor deteriorations in the following areas (no/transient/permanent): orofacial (11/5/0), upper limb (9/5/2), and lower limb (9/3/4). All cases with orofacial motor deterioration underwent cortical resection of the inferior third of the peri-rolandic cortex. Cortical resection of the precentral gyrus only, in contrast to both the precentral and postcentral gyri, was not associated with permanent upper- and/or lower-limb motor deterioration. Cortical resection involving the postcentral gyrus was significantly associated with permanent upper- and/or lower-limb motor deterioration in 4 cases (25.0%). Surgically related perforating artery injury caused ischemic subcortical damage, which was significantly associated with postoperative transient or permanent motor deterioration by extending to the corticospinal tract (CST). CONCLUSIONS: Postoperative motor deterioration for peri-rolandic epilepsy was related to both the resected cortex and ischemic subcortical damage. In peri-rolandic epilepsy, cortical resection of the precentral gyrus might not necessarily cause permanent upper- and/or lower-limb motor deterioration because of the functional reserve in other peri-rolandic areas outside the epileptic focus. On the other hand, cortical resection of the postcentral gyrus could cause permanent upper- and/or lower-limb motor deterioration because of injury to the vasculature, which is crucial for the descending motor pathway in the CST.
Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms). International-journal

Kazuto Katsuse, Kazuo Kakinuma, Shin-Ichiro Osawa, Shoko Ota, Hana Kikuchi, Ai Kawamura, Kazushi Ukishiro, Kazuyo Tanji, Nobuko Kawakami, Chifumi Iseki, Shigenori Kanno, Yuichiro Shirota, Masashi Hamada, Tatsushi Toda, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

NeuroImage　317　121316-121316　2025

DOI： 10.1016/j.neuroimage.2025.121316 　

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Reading engages complex neural networks integrating visual, phonological, and semantic information. The dual-stream model posits ventral and dorsal pathways for lexical and sublexical processing in the left hemisphere and is well-supported in alphabetic languages. However, its applicability to non-alphabetic scripts remains unclear. The Japanese writing system, comprising Kana (syllabograms) and Kanji (morphograms) with distinct orthographic, phonological, and semantic properties, provides a unique framework to investigate neural dissociation between phonological and orthographic-semantic processing. Previous studies suggest that Kanji relies on the ventral route for whole-word recognition and semantic processing, whereas Kana depends mainly on the dorsal route for phonological decoding via grapheme-to-phoneme conversion; however, their spatiotemporal dynamics remain unknown. Using high-gamma power analysis from electrocorticography recordings in 14 patients with epilepsy and subdural implants, we examined the spatiotemporal neural dynamics of Kana and Kanji reading. Participants completed a visual lexical decision task with Kana and Kanji words and pseudowords. Across 912 electrodes, differential high-gamma power analysis showed that Kanji activated bilateral occipitotemporal fusiform regions early (120-550 ms) and the left inferior temporal gyrus (150-240 ms). Conversely, Kana showed prolonged late activation (270-750 ms) in the left-lateralised superior temporal, supramarginal, and inferior frontal gyri, especially during pseudoword processing. These findings indicate that Kanji relies on bilateral ventral stream earlier, while Kana depends on the left dorsal stream, with slower processing reflecting the extra grapheme-to-phoneme conversion. This underscores the value of non-alphabetic languages in elucidating both universal and script-specific neural mechanisms, advancing a cross-linguistic understanding of the reading network.
選択的麻酔薬動注と認知神経学的評価を組み合わせた精密な脳機能評価

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

てんかん研究　42　(3)　664-665　2025/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Verbal Memory Localized in Non-language-dominant Hemisphere: Atypical Lateralization Revealed by Material-specific Memory Evaluation Using Super-selective Wada Test.

Hana Kikuchi, Shin-Ichiro Osawa, Kazuo Kakinuma, Shoko Ota, Kazuto Katsuse, Kazushi Ukishiro, Kazutaka Jin, Hidenori Endo, Nobukazu Nakasato, Kyoko Suzuki

NMC case report journal　12　65-71　2025

DOI： 10.2176/jns-nmc.2024-0217 　

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Hippocampectomy is effective for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis. However, multiple studies have reported high risks associated with hippocampectomy in patients with mesial temporal lobe epilepsy without hippocampal sclerosis on magnetic resonance imaging and in those with preserved memory function. Verbal memory and language functions are believed to coexist in the same hemisphere. We present a case of left mesial temporal lobe epilepsy with atypical memory function lateralization revealed by super-selective infusion of propofol to the intracranial artery (super-selective Wada test). A 24-year-old right-handed man with drug-resistant focal impaired awareness seizures was diagnosed with left mesial temporal lobe epilepsy without hippocampal sclerosis, but he showed preserved verbal intelligence quotient and memory, suggesting a high risk of severe memory decline after hippocampectomy. We performed super-selective Wada test to the posterior cerebral artery to assess the lateralization of verbal and visual memory separately, and to the middle cerebral artery to assess language function. The results revealed right-sided dominance for both verbal and visual memory, although the language was left-dominant. Hippocampectomy was performed and resulted in freedom from seizures. Memory assessments 1 year postoperatively showed no decline in all subtests. In patients with drug-resistant epilepsy exhibiting atypical neuropsychological profiles, the memory-dominant, and language-dominant hemispheres may not align; detailed evaluations of function lateralization are necessary for tailored treatment.
超選択的Wadaテストによって言語優位半球と言語性記憶の優位半球が異なることが明らかになった内側側頭葉てんかんの1症例

菊地花, 大沢伸一郎, 柿沼一雄, 太田祥子, 勝瀬一登, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(3)　665-666　2025/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Successful Total Callosotomy in a Patient with Lennox-Gastaut Syndrome and Cardio-Facio-Cutaneous Syndrome.

Aritomo Kawashima, Haruhiko Nakamura, Kaori Kodama, Yukimune Okubo, Wakaba Endo, Takehiko Inui, Noriko Togashi, Saki Uneoka, Moriei Shibuya, Yoshitsugu Oikawa, Yu Katata, Yurika Numata-Uematsu, Mitsugu Uematsu, Hiroshi Kawame, Shin-Ichiro Osawa, Daiju Oba, Tetsuya Niihori, Yoko Aoki, Kazuhiro Haginoya

The Tohoku journal of experimental medicine　2024/12/19

DOI： 10.1620/tjem.2024.J146 　
Recurring utterances induced by local anesthetic administration to the left frontal lobe. International-journal

Kazuo Kakinuma, Shin-Ichiro Osawa, Hana Kikuchi, Kazuto Katsuse, Makoto Ishida, Kazushi Ukishiro, Kazutaka Jin, Shingo Kayano, Shunji Mugikura, Hidenori Endo, Nobukazu Nakasato, Minoru Matsuda, Kyoko Suzuki

Cortex; a journal devoted to the study of the nervous system and behavior　183　15-20　2024/11/19

DOI： 10.1016/j.cortex.2024.10.019 　

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Recurring utterances (RUs) are a distinct language symptom observed in severe aphasia, known to be associated with global or Broca's aphasia, though their neural basis remains unclear. We present a case of RU induced by selective left frontal suppression using a novel technique named the super-selective Wada test (ssWada), which involves temporary anesthetization of specific brain regions through super-selective catheterization of cerebral arteries. This method allows for precise simulation of localized brain dysfunction. We applied this technique on a 49-year-old right-handed man with drug-resistant epilepsy as a preoperative examination. Propofol administration to the superior branch of the left middle cerebral artery (MCA), supplying the pars triangularis, pars opercularis, middle frontal gyrus, and part of the precentral gyrus, induced Broca's aphasia with RUs. The RU content was the phrase uttered at anesthesia administration. Notably, the anesthetic did not affect the temporal language area or basal ganglia. The patient showed minimal awareness of his abnormal speech despite preserved receptive language function and memory, aligning with previous observations of anosognosia in patients with RU. Contrastingly, anesthetic infusion into the inferior branch of the left MCA resulted in mixed aphasia, while right MCA infusion induced no language impairments. This case demonstrates that RUs can arise without deficits in the posterior language area or basal ganglia. It illustrates the potential of ssWada in investigating neural substrates of neuropsychological symptoms through temporary, localized brain disruption. This approach offers novel insights into brain-behavior relationships in language processing and cognition.
麻酔薬の頭蓋内選択的動注と認知神経学的評価を融合した任意脳領域の機能局在診断法

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 浮城一司, 金森政之, 下田由輝, 新妻邦泰, 松本康史, 神一敬, 中里信和, 遠藤英徳

日本脳神経血管内治療学会学術集会抄録集　40回　330-330　2024/11
Publisher: (一社)日本脳神経血管内治療学会
eISSN： 2759-6907
左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

臨床神経生理学　52　(5)　622-622　2024/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
Spatiotemporal neural dynamics in kanji vs. kana reading: An electroencephalography(ECoG) study(タイトル和訳中)

Katsuse Kazuto, Kakinuma Kazuo, Osawa Shinichiro, Ota Shoko, Kikuchi Hana, Kawamura Ai, Ukishiro Kazushi, Tanji Kazuyo, Iseki Chifumi, Kanno Shigenori, Hamada Masashi, Toda Tatsushi, Endo Hidenori, Nakasato Nobukazu, Suzuki Kyoko

臨床神経学　64　(Suppl.)　S237-S237　2024/10
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Levodopa-resistant parkinsonism developing after ventriculoperitoneal shunting for obstructive hydrocephalus and improving after endoscopic third ventriculostomy, with specific consideration of brainstem morphology: illustrative case. International-journal

Yoshihiko Morisue, Shin-Ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Kyoko Suzuki, Hidenori Endo

Journal of neurosurgery. Case lessons　8　(11)　2024/09/09

DOI： 10.3171/CASE2429 　

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BACKGROUND: Parkinsonism has been reported in patients with obstructive hydrocephalus (OH) following ventriculoperitoneal shunting (VPS). While levodopa works well, some cases are drug resistant. A few case series have reported that endoscopic third ventriculostomy (ETV) is beneficial, though its mechanism remains unclear. The use of a pathophysiology-reflected marker can aid in the diagnosis and treatment strategy. The authors report a case of parkinsonism due to OH after VPS that improved after ETV in a patient taking levodopa, which was subsequently discontinued. OBSERVATIONS: A 52-year-old man who had undergone VPS for OH caused by aqueductal stenosis with a tectal tumor presented with severe consciousness disturbance due to acute hydrocephalus and levodopa-refractory parkinsonism after multiple episodes of shunt malfunction. Magnetic resonance imaging showed an elevation of the floor of the third ventricle. ETV was performed to stabilize the pressure imbalance across the stenosis, and his parkinsonism symptoms improved after long-term rehabilitation, resulting in levodopa discontinuation. His pontomesencephalic angle, the angle between the anterior surface of the midbrain and upper surface of the pons in the midline of the sagittal plane, was significantly decreased. LESSONS: The focus in such cases should be on the essence of the pathophysiology for improving the symptoms rather than on easy-to-understand indicators such as ventricle size. https://thejns.org/doi/10.3171/CASE2429.
てんかん発作症候学ビデオケースセッション脳外科・救急領域でみる心因性非てんかん発作

大沢伸一郎, 岩城弘隆, 小川舞美, 中里信和, 遠藤英徳

てんかん研究　42　(2)　315-315　2024/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Discrepancies in hemispheric dominance of language and memory: A case report using the super-selective Wada test

Kakinuma Kazuo, Osawa Shin-Ichiro, Kikuchi Hana, Ota Shoko, Katsuse Kazuto, Tsuchiya Mario, Ukishiro Kazushi, Jin Kazutaka, Endo Hidenori, Nakasato Nobukazu, Suzuki Kyoko

Japanese Journal of Neuropsychology　40　(3)　231-241　2024/09
Publisher: Neuropsychology Association of Japan
DOI： 10.20584/neuropsychology.17228 　 10.2176/jns-nmc.2024-0217_references_DOI_9O4rNqlLE5vjUgr8oMTt50EK61H 　

ISSN： 0911-1085

eISSN： 2189-9401

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The Wada test is a standard examination protocol for determining hemispheric dominance of language and memory functions. In the Wada test, a short-acting anesthetic is injected into the internal carotid artery, temporarily suppressing brain function on one side. In this study, we performed more precise estimations of memory lateralization using the super-selective Wada test (ssWada), which relies on region-selective short-acting anesthetic administration via a microcatheter. The patient is a 16-year-old right-handed woman who has experienced focal impaired awareness seizures since the age of 6. Imaging studies and electroencephalography indicated right medial temporal lobe epilepsy with right hippocampal sclerosis. As the functional magnetic resonance imaging suggested an atypical hemispheric dominance of language function, we tried directly evaluating her memory lateralization via deactivation study. During the ssWada test of the middle cerebral artery, administering the anesthetic to the right side caused global aphasia, whereas the left infusion produced no language symptoms. During ssWada testing of the posterior cerebral artery, left anesthetic injection significantly impaired encoding of verbal and nonverbal items, whereas right anesthetic injection minimally decreased encoding for both types of items. Following a right anterior temporal lobectomy, the seizures ceased, with no significant postoperative memory loss or decline in daily living activities. In this case, anesthetic injected into the right side of the middle cerebral artery caused language impairment, whereas anesthetic administration into the left posterior cerebral artery caused more severe impairment in verbal and nonverbal memory compared to the contralateral trial. The super-selective Wada test may reveal atypical lateralization of verbal and nonverbal memory and language distribution.
後大脳動脈で灌流される海馬周囲構造への超選択的麻酔は記憶機能のモダリティ別評価を可能にする

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝瀬一登, 菊地花, 浮城一司, 石田誠, 下田由輝, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

てんかん研究　42　(2)　514-514　2024/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
超選択的Wadaテストによる脳領域別の言語機能推定

柿沼一雄, 大沢伸一郎, 勝瀬一登, 菊地花, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(2)　521-521　2024/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Wadaテストにおける記憶スコアは言語機能領域への薬剤注入で低下しうる

菊地花, 大沢伸一郎, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

てんかん研究　42　(2)　522-522　2024/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
右大脳半球への超選択的Wadaテストによる半側空間無視の評価法の開発

勝瀬一登, 柿沼一雄, 大沢伸一郎, 浮城一司, 菊地花, 川村藍, 齋藤治仁, 太田祥子, 伊関千書, 菅野重範, 戸田達史, 遠藤英徳, 中里信和, 鈴木匡子

日本神経心理学会総会プログラム・予稿集　48回　104-104　2024/08
Publisher: 日本神経心理学会
Remission of startle epilepsy provoked by acoustic stimuli following complete callosotomy: A case study. International-journal

Kazushi Ukishiro, Shin-Ichiro Osawa, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Hidenori Endo, Nobukazu Nakasato

Epileptic disorders : international epilepsy journal with videotape　26　(4)　510-513　2024/05/07

DOI： 10.1002/epd2.20238 　

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Herein, we present the case of a 21-year-old man with a history of generalized tonic seizures since the age of 4 years. These seizures occurred either spontaneously or could be provoked by auditory stimuli such as the sounds of a vacuum cleaner or an electric shaver. Despite trials with 10 different anti-seizure medications, his seizures remained refractory. Interictal electroencephalography (EEG) revealed generalized epileptiform activity, whereas ictal EEG showed a generalized attenuation pattern. Magnetic resonance imaging revealed extensive chronic infarctions, predominantly in the bilateral cerebral watershed areas. At the age of 17, the patient underwent a one-stage complete callosotomy, which only achieved remission of auditory-provoked seizures. Based on this experience and published reports, we propose that the posterior corpus callosum, particularly the isthmus and anterior splenium, may be involved in seizures caused by unexpected sound stimuli.
The grasp reflex in patients with idiopathic normal pressure hydrocephalus. International-journal

Junyan Liu, Shigenori Kanno, Chifumi Iseki, Nobuko Kawakami, Kazuo Kakinuma, Kazuto Katsuse, Shiho Matsubara, Shoko Ota, Keiko Endo, Kentaro Takanami, Shin-Ichiro Osawa, Tomohiro Kawaguchi, Hidenori Endo, Shunji Mugikura, Kyoko Suzuki

Journal of neurology　271　(7)　4191-4202　2024/04/08

DOI： 10.1007/s00415-024-12341-0 　

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OBJECTIVE: To investigate the prevalence and intensity of grasp reflexes and to examine changes in these reflexes after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: We enrolled 147 patients with probable iNPH. A standard procedure was used to determine the presence of grasp reflexes, and the intensity of these reflexes was assessed using a four-category classification. Clinical rating scales and their correlation with grasp reflexes were also evaluated. Grasp reflexes were reassessed in 72 patients 1 year after surgery. RESULTS: We found that approximately 50.3% of patients with iNPH exhibited a positive grasp reflex. Among these patients, 69% exhibited bilateral positivity, while the remaining patients showed unilateral positivity. Furthermore, the intensity of the grasp reflex was significantly correlated with the severity of gait and with cognitive, urinary, motor, and behavioural symptoms. Surgical interventions led to a reduction (41.7%) or maintenance (30.6%) of the reflex intensity in 72.3% of iNPH patients. The changes in reflex intensity showed significant positive correlations with changes in the number of steps of the Timed Up and Go test and Trail Making Test-A scores but not with changes in total scores on the iNPH Grading Scale. CONCLUSION: This retrospective study identified grasp reflexes as a highly prevalent phenomenon in patients with iNPH. These reflexes can assist in evaluating the severity of various symptoms, including cognitive, gait, urinary, motor and emotional symptoms.
超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　78-79　2024/03
Publisher: (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　79-79　2024/03
Publisher: (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wadaテストで外側皮質言語機能と言語性記銘力の側方性不一致が示された側頭葉てんかんの一例

柿沼一雄, 大沢伸一郎, 浮城一司, 土屋真理夫, 太田祥子, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　78-79　2024/03
Publisher: (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wadaテストにより非典型的側性化が明らかになった難治性てんかん患者の1例

菊地花, 大沢伸一郎, 浮城一司, 柿沼一雄, 勝瀬一登, 太田祥子, 川村藍, 劉軍艶, 遠藤英徳, 中里信和, 鈴木匡子

高次脳機能研究　44　(1)　79-79　2024/03
Publisher: (一社)日本高次脳機能学会
ISSN： 1348-4818

eISSN： 1880-6554
Distant recurrence in the cerebellar dentate nucleus through the dentato-rubro-thalamo-cortical pathway in supratentorial glioma cases. International-journal

Masayuki Kanamori, Yohei Morishita, Yoshiteru Shimoda, Eiko Yamamori, Shiho Sato, Yoshinari Osada, Shin-Ichiro Osawa, Ichiyo Shibahara, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Hidenori Endo

Acta neurochirurgica　166　(1)　83-83　2024/02/14

DOI： 10.1007/s00701-024-05981-8 　

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BACKGROUND: Distant recurrence can occur by infiltration along white matter tracts or dissemination through the cerebrospinal fluid (CSF). This study aimed to clarify the clinical features and mechanisms of recurrence in the dentate nucleus (DN) in patients with supratentorial gliomas. Based on the review of our patients, we verified the hypothesis that distant DN recurrence from a supratentorial lesion occurs through the dentato-rubro-thalamo-cortical (DRTC) pathway. METHODS: A total of 380 patients with supratentorial astrocytoma, isocitrate dehydrogenase (IDH)-mutant (astrocytoma), oligodendroglioma, IDH mutant and 1p/19q-codeleted (oligodendroglioma), glioblastoma, IDH-wild type (GB), and thalamic diffuse midline glioma, H3 K27-altered (DMG), who underwent tumor resection at our department from 2009 to 2022 were included in this study. Recurrence patterns were reviewed. Additionally, clinical features and magnetic resonance imaging findings before treatment, at the appearance of an abnormal signal, and at further progression due to delayed diagnosis or after salvage treatment of cases with recurrence in the DN were reviewed. RESULTS: Of the 380 patients, 8 (2.1%) had first recurrence in the DN, 3 were asymptomatic when abnormal signals appeared, and 5 were diagnosed within one month after the onset of symptoms. Recurrence in the DN developed in 8 (7.4%) of 108 cases of astrocytoma, GB, or DMG at the frontal lobe or thalamus, whereas no other histological types or sites showed recurrence in the DN. At the time of the appearance of abnormal signals, a diffuse lesion developed at the hilus of the DN. The patterns of further progression showed that the lesions extended to the superior cerebellar peduncle, tectum, tegmentum, red nucleus, thalamus, and internal capsule along the DRTC pathway. CONCLUSION: Distant recurrence along the DRTC pathway is not rare in astrocytomas, GB, or DMG at the frontal lobe or thalamus. Recurrence in the DN developed as a result of the infiltration of tumor cells through the DRTC pathway, not dissemination through the CSF.
海馬硬化を伴う内側側頭葉てんかん患者における側頭葉深部の脳磁図棘波信号源の臨床的意義

大村花薫子, 石田誠, 柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

日本生体磁気学会誌　37　(1)　140-141　2024
Publisher: 日本生体磁気学会
ISSN： 0915-0374
海馬硬化を伴う内側側頭葉てんかん患者における側頭葉深部の脳磁図棘波信号源の臨床的意義

大村花薫子, 石田誠, 柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

日本生体磁気学会誌　37　(1)　140-141　2024
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis International-journal

Shunji Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, Kazutaka Jin, Shin-Ichiro Osawa, Nobukazu Nakasato, Kei Takase

Journal of Clinical Imaging Science　13　38-38　2023/12/22
Publisher: Scientific Scholar
DOI： 10.25259/jcis_77_2023 　

ISSN： 2156-7514

eISSN： 2156-5597

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Objectives: To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Material and Methods: Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Results: Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. Conclusion: By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.
MCSにおける脳合併症を本気で考える脳合併症に対する外科的治療、開頭術の基準とは

大沢伸一郎, 斎木佳克, 遠藤英徳

日本胸部外科学会定期学術集会　76回　CPD4-6　2023/10
Publisher: (一社)日本胸部外科学会
Referral odyssey plot to visualize causes of surgical delay in mesial temporal lobe epilepsy with hippocampal sclerosis. International-journal

Kazutoshi Konomatsu, Yosuke Kakisaka, Makoto Ishida, Temma Soga, Kazushi Ukishiro, Shin-Ichiro Osawa, Kazutaka Jin, Masashi Aoki, Nobukazu Nakasato

Epilepsy & behavior : E&B　147　109434-109434　2023/09/14

DOI： 10.1016/j.yebeh.2023.109434 　

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The "odyssey plot" was used to visualize referral delays in epilepsy surgery. Participants were 36 patients (19 males; 13-67 years, median 27 years) with mesial temporal lobe epilepsy with hippocampal sclerosis (HS) who underwent resection surgery. The "referral odyssey plot" included five clinical episodes: seizure onset (T1), first visits to a non-epileptologist (T2) and to an epileptologist (T3), first admission to our epilepsy monitoring unit (EMU) (T4), and resection surgery (T5). For each patient, we identified the first seizure type: the physician who first diagnosed focal aware seizure (FAS), focal impaired awareness seizure (FIAS), focal to bilateral tonic-clonic seizure (FBTCS), and radiologically suspected HS. Within the overall delay (T1-T5, median 18 years; interquartile range [IQR] 14), non-epileptologist's delay (T2-T3, 11.5 years; IQR 12.25) was far (p < 0.0001) longer than patient's (T1-T2, 0 year; IQR 2.25), epileptologist's (T3-T4, 1 year; IQR 4), or after-EMU delay (T4-T5, 1 year; IQR 1). FAS onset cases had significantly longer T1-T2 (N = 5, median 7 years; IQR 6) than FIAS (N = 22, 0 year; IQR 1, p < 0.005) or FBTCS onset cases (N = 9, 0 year; IQR 0, p < 0.001). FAS was correctly diagnosed first by non-epileptologists in 17.9%, by out-patient epileptologists in 35.7%, and at the EMU in 46.4%. FIAS was correctly diagnosed first by non-epileptologists in 94.4% and by out-patient epileptologists in 5.6%. Non-epileptologists diagnosed FBTCS in all cases. HS was diagnosed by non-epileptologists in 13.9%, by out-patient epileptologists in 47.2%, and at the EMU in 38.9%. Early referral to epileptologists is most critical for early surgery. Early utilization of the EMU is highly recommended because FAS is often overlooked by outpatient epileptologists. The odyssey plot will be useful to improve the healthcare system for other types of epilepsy.
海馬硬化を伴う内側側頭葉てんかんの術後発作転帰予測因子

曽我天馬, 神一敬, 柿坂庸介, 此松和俊, 大沢伸一郎, 岩崎真樹, 鈴木博義, 青木正志, 中里信和

臨床神経学　63　(Suppl.)　S227-S227　2023/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
海馬硬化を伴う内側側頭葉てんかんの術後発作転帰予測因子

曽我天馬, 神一敬, 柿坂庸介, 此松和俊, 大沢伸一郎, 岩崎真樹, 鈴木博義, 青木正志, 中里信和

臨床神経学　63　(Suppl.)　S227-S227　2023/09
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
超選択的頭蓋内麻酔薬注入により、患者は焦点切除後の神経症状を主観的に評価できる

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 石田誠, 新妻邦泰, 神一敬, 植松貢, 中里信和, 遠藤英徳

てんかん研究　41　(2)　358-358　2023/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
MRI陰性側頭葉てんかんの術後発作転帰と発作時心拍数上昇の関係

曽我天馬, 神一敬, 柿坂庸介, 浮城一司, 此松和俊, 久保田隆文, 大沢伸一郎, 岩崎真樹, 鈴木博義, 青木正志, 中里信和

てんかん研究　41　(2)　449-449　2023/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
中大脳動脈上行枝へのプロポフォール注入によって生じた再帰性発話

柿沼一雄, 大沢伸一郎, 浮城一司, 菅野彰剛, 神一敬, 石田誠, 冨永悌二, 中里信和, 松田実, 鈴木匡子

日本神経心理学会総会プログラム・予稿集　47回　99-99　2023/08
Publisher: 日本神経心理学会
Web会議システムを用いた遠隔外来による迷走神経刺激療法の外来刺激調整

古知龍三郎, 大沢伸一郎, 成田徳雄, 柴田憲一, 森田隆弘, 村上謙介, 柿坂庸介, 中里信和, 冨永悌二

てんかん研究　41　(1)　11-16　2023/06
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Stimulation Adjustment of VNS by Telemedicine Using Web Conference System

Kochi Ryuzaburo, Osawa Shin-ichiro, Narita Norio, Shibata Kenichi, Morita Takahiro, Murakami Kensuke, Kakisaka Yousuke, Nakasato Nobukazu, Tominaga Teiji

Journal of the Japan Epilepsy Society　41　(1)　11-16　2023/06
Publisher: JAPAN EPILEPSY SOCIETY
DOI： 10.3805/jjes.41.11 　

ISSN： 0912-0890

eISSN： 1347-5509

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Vagus nerve stimulation is an effective treatment for drug-resistant epilepsy and the number of implants is increasing year by year in Japan. However, it is difficult to adapt VNS for patients living far away from the epilepsy center because stimulus adjustment is required to be done by a committee-certified physician. To overcome this difficulty, we attempted to perform stimulus adjustment by telemedicine using a video conferencing system. Stimulus adjustment was performed by local physician under the guidance of certified epileptologist through a web conference. To clarify the efficacy, we retrospectively investigated surveys we took on local physician regarding feasibility of the adjustment, system trouble, and handling of adverse effect, urgent contact. Twelve VNS stimulus adjustment procedures by telemedicine on 3 patients were included. In all procedure, adjustment and handling of adverse effect were successful with no system trouble and no urgent contact from patient were reported. Stimulus Adjustment by telemedicine using a video conference is feasible, safe and to be considered as a clinical choice to improve the problem of difficulties in accessing epilepsy center or certified epileptologist.
Olfactory Dysfunction, an Often Neglected Symptom of Hydrocephalus: Experience from a Case of Late-Onset Idiopathic Aqueductal Stenosis International-journal

Naoya Yamazaki, Takafumi Hasegawa, Kensuke Ikeda, Ako Miyata, Shin-ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Teiji Tominaga, Masashi Aoki

Case Reports in Neurology　15　(1)　41-47　2023/03/01
Publisher: S. Karger AG
DOI： 10.1159/000529532 　

eISSN： 1662-680X

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Disturbance of smell is often accompanied with common neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. In addition, patients with head trauma, intracranial tumors, and hydrocephalus can also develop olfactory dysfunction, and some of which can improve with treatment of the underlying disease. In clinical practice, few patients complain of smell disturbances, thus olfactory dysfunction is often overshadowed by visible motor symptoms. Herein, we report a case of late-onset idiopathic aqueductal stenosis, a rare form of adult-onset hydrocephalus in which olfactory dysfunction and gait disturbance was markedly improved after endoscopic ventriculostomy. This case report is expected to make more physicians aware that hydrocephalus can cause olfactory dysfunction and that it can be corrected postoperatively. Furthermore, in addition to motor and neuropsychological function, olfactory function test might be useful for functional assessment before and after surgical treatment of hydrocephalus.
側頭葉てんかん患者において深部に推定される発作間欠時棘波信号源の臨床的意義

石田誠, 大村花薫子, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 安藤康夫, 中里信和

日本生体磁気学会誌　36　(1)　160-161　2023
Publisher: 日本生体磁気学会
ISSN： 0915-0374
[COLUMN: How We Get Along the New ILAE Classification of Epilepsy and Epileptic Seizure].

Shin-Ichiro Osawa, Teiji Tominaga

No shinkei geka. Neurological surgery　51　(1)　29-32　2023/01
Publisher:
DOI： 10.11477/mf.1436204712 　

ISSN： 0301-2603

eISSN： 1882-1251
側頭葉てんかん患者において深部に推定される発作間欠時棘波信号源の臨床的意義

石田誠, 大村花薫子, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 安藤康夫, 中里信和

日本生体磁気学会誌　36　(1)　160-161　2023
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Distribution of postictal slowing has an additional yield to interictal epileptiform discharge in predicting surgical outcomes in temporal lobe epilepsy. International-journal

Sally Shaaban, Yosuke Kakisaka, Tamer Belal, Kazutaka Jin, Shin-Ichiro Osawa, Teiji Tominaga, Ibrahim Elmenshawi, Nobukazu Nakasato

Epilepsia open　7　(4)　802-809　2022/10/12

DOI： 10.1002/epi4.12660 　

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OBJECTIVE: To investigate whether the slowing of bilateral postictal scalp electroencephalography (EEG) after focal impaired awareness seizures is associated with poor seizure outcomes after temporal lobe epilepsy (TLE) surgery. METHODS: This retrospective cohort study was conducted in the Department of Epileptology, Tohoku University Hospital from 2010 to 2020. The study included 42 patients with TLE who underwent a detailed presurgical evaluation and sequential resective surgery for the unilateral probable epileptogenic temporal lobe with one year or more of follow-up. We reviewed the interictal epileptiform distribution and those of the ictal and postictal epochs of the first focal impaired awareness seizure recorded in presurgical scalp EEG. We classified patients either with postoperative seizure-free status (Engel I) as group A or those with seizure persistence (Engel II-IV) as group B. RESULTS: Of 42 patients, 29 (69 %) were classified into group A. Compared with group B, group A had a lower number of bilateral postictal polymorphic delta activity (PPDA) (10.3%: 61.5%) and bilateral interictal epileptiform discharges (IEDs) (13.8%: 69.2%) (p=0.003, p=0.001, respectively). A combined analysis of bilateral PPDA and IEDs per individual patient showed significantly more frequent seizure persistence after surgery (p <0.0001) than a single analysis of bilateral IEDs or PPDA alone (p=0.001). The regression analysis revealed that bilaterally distributed PPDA or IEDs had 13.50 or 13.72 times higher odds of persisting seizures within 1 year of surgery (95% confidence interval: 1.90-95.88; 2.12-88.87, respectively) (p=0.009, 0.006). SIGNIFICANCE: The results of this study revealed that the bilateral distribution of PPDA was associated with poor postoperative seizure outcomes in patients with TLE, as well as bilateral IEDs. Additionally, the concomitant bilateral distribution of interictal and postictal changes is a strong indicator of poor surgical outcomes.
問題症例のMEG 海馬硬化症を伴う左内側側頭葉てんかんにおけるMEGとfMRIによる言語左右差の不一致(Left mesial temporal epilepsy with hippocampal sclerosis showing discordance of language laterality between MEG and fMRI)

古知龍三郎, 神一敬, 石田誠, 菅野彰剛, 大沢伸一郎, 岩崎真樹, 冨永悌二, 中里信和

臨床神経生理学　50　(5)　344-344　2022/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
発作間欠期spike関連ripple解析を用いたてんかん原性部位の推定について

植松貢, 植松有里佳, 平田理絵, 大沢伸一郎, 神一敬, 岩崎真樹, 中里信和

臨床神経生理学　50　(5)　427-427　2022/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
Correction to: Methodological assessment of the reduction of dissemination risk and quantification of debris dispersion during dissection with a surgical aspirator. International-journal

Sosuke Kageyama, Atsuhiro Nakagawa, Tomohiro Kawaguchi, Kiyonobu Ohtani, Toshiki Endo, Manabu Kyan, Tetsuya Kusunoki, Yoshiteru Shimoda, Shin-Ichiro Osawa, Masayuki Kanamori, Kuniyasu Niizuma, Teiji Tominaga

BMC research notes　15　(1)　279-279　2022/08/15

DOI： 10.1186/s13104-022-06167-0 　
てんかん原性病変の切除範囲〜取り切ることの意義を考える〜てんかん原性病変の切除範囲Focal cortical dysplasiaについて

大沢伸一郎, 浮城一司, 下田由輝, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

てんかん研究　40　(2)　273-274　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
混乱するlow-grade epilepsy-associated neuroepithelial tumors(LEAT)の概念切除外科の視点からLEAT概念を考える

大沢伸一郎, 浮城一司, 下田由輝, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

てんかん研究　40　(2)　282-283　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
てんかん診療の近未来〜デバイスと医薬品開発の最前線〜ハイドロゲル-有機物を基材とする新規頭蓋内電極の開発

大沢伸一郎, 西澤松彦, 中川敦寛, 岩崎真樹, 鈴木泰汎, 下田由輝, 中里信和, 冨永悌二

てんかん研究　40　(2)　309-309　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
外科治療を行った小児期発症の島回・弁蓋部てんかん3例の検討

植松有里佳, 大沢伸一郎, 堅田有宇, 神一敬, 中里信和, 植松貢

てんかん研究　40　(2)　379-379　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
海馬硬化を伴う内側側頭葉てんかんの臨床脳波的特徴

曽我天馬, 神一敬, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 鈴木博義, 青木正志, 冨永悌二, 中里信和

てんかん研究　40　(2)　397-397　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
呼称関連スペクトル応答を組み込んだAI予測モデルによるてんかん術後の認知機能の転帰予測

園田真樹, 林貴啓, 池谷直樹, 高山裕太郎, 東島威史, 飯村圭哉, 大沢伸一郎, 岩崎真樹, 中里信和, 山本哲哉, 浅野英司

てんかん研究　40　(2)　414-414　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Web会議システムを用いた遠隔外来による迷走神経刺激療法の外来刺激調整

古知龍三郎, 大沢伸一郎, 成田徳雄, 柴田憲一, 村上謙介, 柿坂庸介, 神一敬, 中里信和, 冨永悌二

てんかん研究　40　(2)　448-448　2022/08
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
限局性皮質異形成に伴う難治性てんかんに対し弁蓋部皮質を含む焦点切除術を行った1例

宇根岡紗希, 植松貢, 西條直也, 相原悠, 渋谷守栄, 宮副貴光, 堅田有宇, 及川善嗣, 植松有里佳, 浮城一司, 大沢伸一郎, 中里信和, 冨永悌二, 呉繁夫

脳と発達　54　(4)　286-286　2022/07
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
限局性皮質異形成に伴う難治性てんかんに対し弁蓋部皮質を含む焦点切除術を行った1例

宇根岡紗希, 植松貢, 西條直也, 相原悠, 渋谷守栄, 宮副貴光, 堅田有宇, 及川善嗣, 植松有里佳, 浮城一司, 大沢伸一郎, 中里信和, 冨永悌二, 呉繁夫

脳と発達　54　(4)　286-286　2022/07
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
Age-Related Recovery of Daily Living Activity After 1-Stage Complete Corpus Callosotomy: A Retrospective Analysis of 41 Cases. International-journal

Kazushi Ukishiro, Shin-Ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin, Mitsugu Uematsu, Tetsuya Yamamoto, Teiji Tominaga, Nobukazu Nakasato

Neurosurgery　90　(5)　547-551　2022/05/01

DOI： 10.1227/neu.0000000000001871 　

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BACKGROUND: Recovery time after corpus callosotomy (CC) is known to be longer in elderly than in younger patients. OBJECTIVE: To evaluate the relationship between patient age and recovery time of activities of daily living (ADL) after 1-stage complete CC. METHODS: This study included 41 patients (22 women; aged 13 months-34 years, median 7 years) who underwent 1-stage complete CC for medically intractable seizures with drop attacks, infantile spasms, and/or bilaterally synchronized electroencephalographic discharges between August 2009 and April 2019. The timing of restart of competence in 5 ADL categories and surgical outcomes were recorded. RESULTS: Patients (1) restarted speech at 2.2 ± 1.3 (mean ± 2 standard deviations; range 1-5) days, (2) restarted replying with their own name on request at 5.5 ± 8.6 (2-33) days, (3) restarted oral intake at 1.6 ± 1.7 (1-11) days, (5) discontinued intravenous feeding at 6.0 ± 3.0 (2-16) days, and (5) restarted ambulation or wheelchair movement at 5.8 ± 3.4 (2-10) days. Younger patients showed significantly (P < .0223) earlier recovery of ambulation or wheelchair movement, but no age difference was found in the other 4 ADL categories. Overall seizure freedom was achieved in 5 patients, excellent (>80%) seizure reduction in 11, good (50%-80%) seizure reduction in 5, and poor (<50%) seizure reduction in 20. CONCLUSION: Early ADL recovery after 1-stage complete CC is favorable in both young and adult patients. These findings, with good surgical outcomes, will encourage more positive consideration of 1-stage complete CC in both pediatric and adult patients.
Methodological assessment of the reduction of dissemination risk and quantification of debris dispersion during dissection with a surgical aspirator. International-journal

Sosuke Kageyama, Atsuhiro Nakagawa, Tomohiro Kawaguchi, Kiyonobu Ohtani, Toshiki Endo, Manabu Kyan, Tetsuya Kusunoki, Yoshiteru Shimoda, Shin-Ichiro Osawa, Masayuki Kanamori, Niizuma Kuniyasu, Teiji Tominaga

BMC research notes　15　(1)　85-85　2022/03/02

DOI： 10.1186/s13104-022-05947-y 　

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OBJECTIVE: We developed an actuator-driven pulsed water jet (ADPJ) device to achieve maximal lesion dissection with minimal risk of normal structural damage. Despite the unique dissection characteristics, there is a risk of dissemination of tissue dispersion; however, there is no established method to quantify the dispersion. Hence, this study aimed to assess the factors associated with dispersion and propose a simple experimental method using spectrophotometry to evaluate the degree of dispersion in a wet field. RESULTS: Methylene blue-stained brain phantom gelatin was immersed in a chamber with distilled water solution and dissected with an ADPJ. The dispersed gelatin solution was stirred and warmed to dissolve. The absorbance of the solution was measured spectrophotometrically. First, a reference standard curve was constructed to confirm the relationship between the absorbance and the amount of the dispersed gelatin. A clear proportional correlation was observed, which indicated that absorbance measurements can help evaluate the amount of dispersion. Using this method, we revealed that a high dissection force, insufficient suction, and inappropriate long distance between the nozzle tip and the target were associated with increased dispersion. This method might constitute a versatile and reliable approach to evaluate dispersion and aid in the development of surgical devices.
超選択的Wada Testにおける片麻痺に対する病態失認の検討

細川大瑛, 大沢伸一郎, 柿沼一雄, 太田祥子, 親富祖まりえ, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

高次脳機能研究　42　(1)　71-72　2022/03
Publisher: (一社)日本高次脳機能障害学会
ISSN： 1348-4818

eISSN： 1880-6554
言語症状に対する内観と失語型との対応超選択的Wadaテストによる検討

柿沼一雄, 大沢伸一郎, 細川大瑛, 親富祖まりえ, 太田祥子, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

高次脳機能研究　42　(1)　97-97　2022/03
Publisher: (一社)日本高次脳機能障害学会
ISSN： 1348-4818

eISSN： 1880-6554
超選択的Wada Testにおける片麻痺に対する病態失認の検討

細川大瑛, 大沢伸一郎, 柿沼一雄, 太田祥子, 親富祖まりえ, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

高次脳機能研究　42　(1)　71-72　2022/03
Publisher: (一社)日本高次脳機能障害学会
ISSN： 1348-4818

eISSN： 1880-6554
言語症状に対する内観と失語型との対応超選択的Wadaテストによる検討

柿沼一雄, 大沢伸一郎, 細川大瑛, 親富祖まりえ, 太田祥子, 浮城一司, 石田誠, 神一敬, 中里信和, 新妻邦泰, 冨永悌二, 鈴木匡子

高次脳機能研究　42　(1)　97-97　2022/03
Publisher: (一社)日本高次脳機能障害学会
ISSN： 1348-4818

eISSN： 1880-6554
Rescue of distally placed stents in the setting of internal carotid artery dissection: A report of 2 cases with mechanistic insights. International-journal

Tomohisa Ishida, Hiroyuki Sakata, Masayuki Ezura, Shinichiro Osawa, Atsushi Saito, Teiji Tominaga

Clinical neurology and neurosurgery　214　107174-107174　2022/02/11

DOI： 10.1016/j.clineuro.2022.107174 　

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Potential procedural complications of endovascular therapy for carotid artery dissection have not been clarified. Herein, we present the cases of a 46-year-old woman and a 59-year-old man who underwent carotid artery stenting for left cervical internal carotid artery dissection. During the procedure, intramural hematoma was squeezed out by stent placement, causing further extension of the pseudolumen and a prominent stenosis proximal to the stent. Additional stent deployment was subsequently performed to fully cover the newly arising stenosis, resulting in good recanalization. In cases with a long-affected lesion, we should consider the potential risk of dissection advancement following stent deployment. Using longer stents or additional rescue stenting would be efficient in counteracting this rare complication.
The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone

Yurika Numata-Uematsu, Mitsugu Uematsu, Rie Sakuraba, Masaki Iwasaki, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Shigeo Kure

Frontiers in Neurology　12　2021/11/04
Publisher: Frontiers Media SA
DOI： 10.3389/fneur.2021.724417 　

eISSN： 1664-2295

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<bold>Objective:</bold> Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ. <bold>Methods:</bold> The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80–200 Hz) and investigated whether they are within the resection area. <bold>Results:</bold> We retrospectively examined 12 serial patients who achieved seizure-free status after focal resection surgery. Using the method that we developed, we determined the onset channels of interictal spike-related ripples and found that for all 12 patients, they were among the resection channels. The onset frequencies of ripples were in the range of 80–150 Hz. However, the ictal onset channels (evaluated based on ictal ECoG patterns) and ripple onset channels coincided in only 3 of 12 patients. <bold>Conclusions:</bold> Determining the onset area of interictal spike-related ripples could facilitate EZ estimation. This simple method that utilizes interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.
開頭術後に生じた心因性非てんかん発作に心理社会的アプローチが著効した1例

小川舞美, 大沢伸一郎, 上利大, 柿坂庸介, 神一敬, 冨永悌二, 中里信和

脳神経外科速報　31　(6)　e1-e11　2021/11
Publisher: (株)メディカ出版
ISSN： 0917-1495

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16歳女性。前医にて脳動静脈奇形摘出術を受けたが、術後14日目より意識消失発作が出現した。症候性てんかんとして治療されるも、意識消失発作を繰り返すため、術後2ヵ月で当院へ紹介となった。入院後、長時間ビデオ脳波モニタリング検査(VEEG)を実施したところ、心因性非てんかん発作(PNES)と診断された。以後、心理社会的評価を行った結果、PNESの発症や慢性化の背景が明確となり、本人へ病態説明を行うことでPNESの消失が得られた。
麻酔薬の超選択的頭蓋内動脈による神経症状誘発は脳実質切除後の機能転帰を予測する

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

脳血管内治療　6　(Suppl.)　S337-S337　2021/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
麻酔薬の超選択的頭蓋内動脈による神経症状誘発は脳実質切除後の機能転帰を予測する

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

脳血管内治療　6　(Suppl.)　S337-S337　2021/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Aphasic status epilepticus after glioma resection: two case reports. International-journal

Yoshiteru Shimoda, Masayuki Kanamori, Ryuta Saito, Shinichiro Osawa, Shunji Mugikura, Teiji Tominaga

Acta neurochirurgica　163　(11)　3109-3113　2021/11

DOI： 10.1007/s00701-021-04984-z 　

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Aphasic status epilepticus (ASE) is a subtype of focal nonconvulsive status epilepticus, in which language disturbance is the only objective clinical manifestation. We present two cases of patients who experienced delayed onset of temporal aphasia after the removal of glioma at the language-dominant hemisphere. In both cases, arterial spin labeling was useful for diagnosis and antiepileptic drug was effective. ASE should be considered a cause of persistent aphasia after glioma resection at or near the language area.
Psychogenic non-epileptic seizures after craniotomy cured by;psychosocial intervention;a case report Peer-reviewed

Maimi Ogawa, Shin-ichiro Osawa, Dai Agari, Yosuke Kakisaka, Kazutaka Jin, Teiji Tominaga, Nobukazu Nakasato

Current Practical Neurosurgery　31　(6)　e20213106a-e11　2021/11
Publisher:
ISSN： 0917-1495
遠隔医療D to D:ひとりで悩まないためにオンライン医学教育の意義と運用の実際遠隔てんかん症例検討会の経験から

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

臨床神経生理学　49　(5)　320-320　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
頭蓋内動脈への超選択的麻酔薬注入による詳細な神経症状評価と手術適応への寄与

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

臨床神経生理学　49　(5)　449-449　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
てんかん脳磁図:当院のベスト・オブ・ザ・ベスト脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

石田誠, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 浮城一司, 冨永悌二, 中里信和

臨床神経生理学　49　(5)　350-350　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
遠隔医療D to D:ひとりで悩まないためにオンライン医学教育の意義と運用の実際遠隔てんかん症例検討会の経験から

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

臨床神経生理学　49　(5)　320-320　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
てんかん脳磁図:当院のベスト・オブ・ザ・ベスト脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

石田誠, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 浮城一司, 冨永悌二, 中里信和

臨床神経生理学　49　(5)　350-350　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
頭蓋内動脈への超選択的麻酔薬注入による詳細な神経症状評価と手術適応への寄与

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

臨床神経生理学　49　(5)　449-449　2021/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
Computational hemodynamic analysis of the offending vertebral artery at the site of neurovascular contact in a case of hemifacial spasm associated with subclavian steal syndrome: illustrative case. International-journal

Keita Tominaga, Hidenori Endo, Shin-Ichiro Sugiyama, Shin-Ichiro Osawa, Kuniyasu Niizuma, Teiji Tominaga

Journal of neurosurgery. Case lessons　2　(12)　CASE21447　2021/09/20

DOI： 10.3171/CASE21447 　

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BACKGROUND: Hemifacial spasm (HFS) is caused by neurovascular contact along the facial nerve's root exit zone (REZ). The authors report a rare HFS case that was associated with ipsilateral subclavian steal syndrome (SSS). OBSERVATIONS: A 42-year-old man with right-sided aortic arch presented with progressing left HFS, which was associated with ipsilateral SSS due to severe stenosis of the left brachiocephalic trunk. Magnetic resonance imaging showed contact between the left REZ and vertebral artery (VA), which had shifted to the left. The authors speculated that the severe stenosis at the left brachiocephalic trunk resulted in the left VA's deviation, which was the underlying cause of the HFS. The authors performed percutaneous angioplasty (PTA) to dilate the left brachiocephalic trunk. Ischemic symptoms of the left arm improved after PTA, but the HFS remained unchanged. A computational fluid dynamics study showed that the high wall shear stress (WSS) around the site of neurovascular contact decreased after PTA. In contrast, pressure at the point of neurovascular contact increased after PTA. LESSONS: SSS is rarely associated with HFS. Endovascular treatment for SSS reduced WSS of the neurovascular contact but increased theoretical pressure of the neurovascular contact. Physical release of the neurovascular contact is the best treatment option for HFS.
MRI陰性・FDG-PET陽性側頭葉てんかんの前部側頭葉切除術後の発作転帰を頭皮脳波所見で予測できるか?

曽我天馬, 神一敬, 大沢伸一郎, 岩崎真樹, 青木正志, 中里信和

てんかん研究　39　(2)　317-317　2021/07
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
一期的全脳梁離断術における手術時年齢と術後転帰の検討

浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 植松貢, 山本哲哉, 冨永悌二, 中里信和

てんかん研究　39　(2)　341-341　2021/07
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
青森県の地方医療におけるてんかん外科外来の役割

大沢伸一郎, 柿坂庸介, 浮城一司, 神一敬, 村上謙介, 川村強, 中里信和, 冨永悌二

てんかん研究　39　(2)　363-363　2021/07
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
A Case of Cavernous Sinus Dural Arteriovenous Fistula Successfully Treated by Transarterial Embolization with Embosphere

CHEN Mengge, OSAWA Shin-ichiro, NIIZUMA Kuniyasu, ENDO Hidenori, TOMINAGA Teiji

No Kekkannai Chiryo　6　(1)　38-43　2021/05
Publisher: The Japanese Society for Neuroendovascular Therapy
DOI： 10.20626/nkc.cr.2020-0021 　

ISSN： 2423-9119

eISSN： 2424-1709

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Objective: To show the case of cavernous sinus dural arteriovenous fistula (CS-dAVF) difficult for transvenous embolization treated by transarterial embolization (TAE) from the artery that fed cranial nerve with tris-acryl gelatin microspheres (embosphere) successfully. Case Presentation: A 74-year-old woman presented with left conjunctival hyperemia, chemosis, exophthalmos and abducens nerve palsy. Magnetic resonance imaging showed signal void sign and dilation of the left superior ophthalmic vein. Cerebral angiography from the left external carotid artery showed the fistula between the cavernous sinus branch of middle meningeal artery and the lateral wall of left cavernous sinus, and she was diagnosed with left CS-dAVF. We tried transvenous embolization (TVE) but failed because of the complete occlusion of internal jugular vein as an access route to shunting point. Consequently, we tried transarterial embolization (TAE) using Embosphere to obstruct the proximal of cavernous sinus branch of MMA and the shunt disappeared. All the symptoms have been disappearing without recurrence in two years after TAE. Conclusion: It is worth to try TAE with Embosphere in the case of dAVF as an alternative treatment of TVE.
エンボスフィアを用いた経動脈的塞栓で根治し得た海綿静脈洞部硬膜動静脈瘻の1例

陳梦格, 大沢伸一郎, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療　6　(1)　38-43　2021/05
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
Effect of endoscope flexibility on tissue dissection profile assessed with pulsed water jet device: ensuring safety, efficacy, and handling of thin devices for neuroendoscopic surgery. International-journal

Tetsuya Kusunoki, Tomohiro Kawaguchi, Atsuhiro Nakagawa, Yuta Noguchi, Shin-Ichiro Osawa, Hidenori Endo, Toshiki Endo, Ryuta Saito, Masayuki Kanamori, Kuniyasu Niizuma, Teiji Tominaga

BMC research notes　14　(1)　64-64　2021/02/17

DOI： 10.1186/s13104-021-05475-1 　

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OBJECTIVE: We developed an actuator-driven pulsed water jet device (ADPJ) for flexible neuroendoscopy to achieve effective tissue dissection with vasculature preservation. Although flexibility is a strong advantage for minimally invasiveness, the effect of the ductile curvature on the dissection profiles remains unknown. The purpose of this study was to clarify the impact of the curvature change of the ADPJ connecting tube on the dissection safety and efficacy. RESULTS: Three ADPJ connecting tubes with different inner diameters (1.0, 0.75, 0.5 mm) were used to dissect the brain phantom. They were bent at 3 angles: 0°, 60°, and 120°. The dissection profiles were evaluated using the mean depth and coefficient of variation (CV) for efficacy and safety, respectively.The larger inner diameter connecting tube dissected more deeply. The dissection depth was not changed regardless of the curvature degree in each tube. There was no significant difference in CVs regardless of inner diameter and curvature. The ductile curvature of the flexible neuroendoscope did not affect the efficacy and safety of the ADPJ dissection profile. Among the numerous instruments, tube-formed devices, including suction and injecting devices such as ADPJ, can be used safely and effectively without flexibility-related limitations.
オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

日本遠隔医療学会学術大会プログラム・抄録集　24回　161-161　2021/02
Publisher: (一社)日本遠隔医療学会
Utility of short-living finger marker function during online education presentations

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和, 中里信和

JTTA Spring Conference抄録集　24回　161-161　2021/02
Publisher:
External validation of the Epilepsy Surgery Grading Scale in a Japanese cohort of patients with epilepsy. International-journal

Franchesca Gabriel, Yosuke Kakisaka, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Teiji Tominaga, Nobukazu Nakasato

Epileptic disorders : international epilepsy journal with videotape　23　(1)　104-110　2021/02/01

DOI： 10.1684/epd.2021.1238 　

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The Epilepsy Surgery Grading Scale (ESGS) is a simple method to predict the likelihood of a patient with epilepsy proceeding to surgery and achieving seizure freedom. Usefulness of the ESGS has been confirmed in established epilepsy centres in the United States and Belgium for adult patients with drug-resistant focal epilepsy undergoing presurgical evaluation. However, the applicability of the ESGS has not yet been evaluated in a wider range of epilepsy patients that may reflect the general spectrum of epilepsy. The present study validated the ESGS in a Japanese epilepsy centre in which admission-based comprehensive epilepsy studies were indicated beyond presurgical evaluation. This single-centre retrospective study included adult patients with epilepsy admitted to the Epilepsy Monitoring Unit from 2010 to June 2019. Patients were classified as ESGS Grade 1 (most favorable), Grade 2 (intermediate), and Grade 3 (least favourable). Patients were grouped into three cohorts: all patients, patients with drug-resistant focal epilepsy, and patients who underwent resective epilepsy surgery. We assessed progression to surgery and seizure freedom at one year after surgery. Of the 1,158 total admissions, 670 patients met the inclusion criteria and formed the total cohort. Of these, 435 (64.9%) had drug-resistant focal epilepsy and 78 (11.6%) proceeded to resective surgery. Overall, progression to surgery was observed in 41.3%, 16.6%, and 4.8% of patients with Grade 1, 2, and 3, respectively. In the surgical cohort, seizure freedom was observed in 85.2%, 65.2%, and 31.3% of patients with Grade 1, 2, and 3, respectively. Our results indicate that the ESGS is effective in predicting whether a patient proceeds to epilepsy surgery and achieves seizure freedom even in the general population of epilepsy patients, regardless of type or resistance to antiepileptic drugs.
Double-lumen Carotid Plaque Associated with Severe Stenosis Treated with Staged Angioplasty: A Case Report.

Yoshimichi Sato, Shinichiro Osawa, Norio Narita, Teiji Tominaga

NMC case report journal　8　(1)　359-365　2021

DOI： 10.2176/nmccrj.cr.2020-0205 　

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Double-lumen carotid plaque is a rare pathological condition, and only few reports about this condition have been recorded in the literature. However, no study has used endovascular therapy (EVT) for the treatment of double-lumen carotid plaque. Herein, we present a unique case of double-lumen carotid plaque associated with severe stenosis that was successfully treated with staged angioplasty (SAP). Moreover, a literature review of its pathology and other treatment options has been conducted. SAP is a two-stage carotid artery stenting (CAS) that can prevent hyperperfusion syndrome after revascularization. In this study, a 62-year-old man developed walking disturbance and left hemiparesis. Magnetic resonance imaging (MRI) revealed ischemic lesions in the watershed area of the right hemisphere and an irregular plaque in the right cervical internal carotid artery (ICA). Ultrasonography showed 84% stenosis in the area and a double lumen distal to the stenosis in the right ICA. Digital subtraction angiography (DSA) revealed a double-lumen plaque with 70% stenosis based on the North American Symptomatic Carotid Endarterectomy Trial criteria. SAP was performed after medication therapy and rehabilitation, and the surgery was uneventful. A double-lumen carotid plaque associated with severe stenosis is a rare condition with a high risk of emboli and stroke. In an unstable lesion, carotid endarterectomy is the first option. However, since the patient in this case was at high risk for general anesthesia, SAP was performed. Hence, if an appropriate device is used, EVT can be a safe treatment strategy for unstable and atypical plaques as in this case.
Epilepsy in Five Long-term Survivors of Pineal Region Tumors.

Yutaro Takayama, Kazutaka Jin, Shin-Ichiro Osawa, Masaki Iwasaki, Kazushi Ukishiro, Yosuke Kakisaka, Teiji Tominaga, Tetsuya Yamamoto, Nobukazu Nakasato

NMC case report journal　8　(1)　773-780　2021

DOI： 10.2176/nmccrj.cr.2021-0093 　

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Cognitive decline is a well-known chronic side effect of multidisciplinary treatment of pineal region tumors, whereas epilepsy is an under-reported chronic consequence caused by multiple potential factors including radiotherapy, surgery, or chemotherapy. Some long-term survivors have suffered drug-resistant epilepsy after treatment, which impaired the quality of life. We report five consecutive patients with drug-resistant epilepsy after combined treatment of pineal region tumor (5 men, aged 21-42 years) among 1201 epilepsy patients who underwent comprehensive evaluation in our tertiary epilepsy center from 2011 to 2018. The comprehensive epilepsy evaluation included medical interview, long-term video electroencephalography (EEG) monitoring (VEM), and magnetic resonance (MR) imaging. The patients started to have seizures at 2-22 years after initial treatment for the tumor. Four of the five patients had focal impaired awareness seizures, whereas one patient had only visual aura. All patients had EEG seizures during VEM, which confirmed the diagnosis of focal epilepsy, but three patients had no interictal epileptiform discharges (IEDs). Two patients had diagnoses of focal epilepsy arising from the left occipital region based on ictal EEG findings. Both patients had MR imaging lesion in the left occipital lobe, radiation-induced cavernoma, or surgical injury. The remaining three patients showed poor localization of epileptogenic foci based on VEM and MR imaging. Drug-resistant epilepsy after multidisciplinary treatment of pineal region tumor is characterized by focal impaired awareness seizures with poorly localized EEG onset or rare interictal spikes.
The Onset of Interictal Spike-Related Ripples Facilitates Detection of the Epileptogenic Zone. International-journal

Yurika Numata-Uematsu, Mitsugu Uematsu, Rie Sakuraba, Masaki Iwasaki, Shinichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Shigeo Kure

Frontiers in neurology　12　724417-724417　2021

DOI： 10.3389/fneur.2021.724417 　

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Objective: Accurate estimation of the epileptogenic zone (EZ) is essential for favorable outcomes in epilepsy surgery. Conventional ictal electrocorticography (ECoG) onset is generally used to detect the EZ but is insufficient in achieving seizure-free outcomes. By contrast, high-frequency oscillations (HFOs) could be useful markers of the EZ. Hence, we aimed to detect the EZ using interictal spikes and investigated whether the onset area of interictal spike-related HFOs was within the EZ. Methods: The EZ is considered to be included in the resection area among patients with seizure-free outcomes after surgery. Using a complex demodulation technique, we developed a method to determine the onset channels of interictal spike-related ripples (HFOs of 80-200 Hz) and investigated whether they are within the resection area. Results: We retrospectively examined 12 serial patients who achieved seizure-free status after focal resection surgery. Using the method that we developed, we determined the onset channels of interictal spike-related ripples and found that for all 12 patients, they were among the resection channels. The onset frequencies of ripples were in the range of 80-150 Hz. However, the ictal onset channels (evaluated based on ictal ECoG patterns) and ripple onset channels coincided in only 3 of 12 patients. Conclusions: Determining the onset area of interictal spike-related ripples could facilitate EZ estimation. This simple method that utilizes interictal ECoG may aid in preoperative evaluation and improve epilepsy surgery outcomes.
Ocular neuromyotonia caused by a recurrent sphenoidal ridge meningioma. International-journal

Yuto Shingai, Hidenori Endo, Toshiki Endo, Shin-Ichiro Osawa, Kuniyasu Nizuma, Teiji Tominaga

Surgical neurology international　12　219-219　2021

DOI： 10.25259/SNI_38_2021 　

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Background: Ocular neuromyotonia (ONM) is a rare ocular motility disorder characterized by involuntary paroxysmal extraocular muscle contraction and is caused by radiation therapy, vascular compression, and inflammatory disease. This study includes a rare case of ONM caused by a recurrent meningioma. Case Description: A 56-year-old man presented with diplopia due to the right oculomotor nerve palsy caused by a sphenoidal atypical meningioma, with improved symptoms after initial surgery. During the next 7 years, he underwent local radiation therapy, second surgery, and Gamma Knife radiosurgery to control the tumor's repetitive recurrence around the right anterior clinoid process. After these treatments, residual tumor was controlled for the next 3 years. However, 3 months after his last visit, he started to suffer from the right ONM and visual disturbance. The magnetic resonance imaging results revealed a rapid growth of the posterior part of the residual tumor, involving the right oculomotor nerve. The third tumor resection was performed to prevent further aggravation of the symptoms. Decompression of the right oculomotor nerve was achieved, and ONM disappeared immediately after surgery. Conclusion: If nerve compression by the tumor is clearly indicated with the neuroradiological assessment, surgical intervention is the treatment of choice to improve ONM.
オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

日本遠隔医療学会雑誌　16　(2)　145-147　2020/12
Publisher: (一社)日本遠隔医療学会
ISSN： 1880-800X
オンライン教育のプレゼンテーションにおける残像効果のある「指マーカー機能」の有用性

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

日本遠隔医療学会雑誌　16　(2)　145-147　2020/12
Publisher: (一社)日本遠隔医療学会
ISSN： 1880-800X
てんかん診療における遠隔外来と包括的入院精査の相補的利用

柿坂庸介, 大沢伸一郎, 成田徳雄, 神一敬, 冨永悌二, 中里信和

脳神経外科速報　30　(11)　1254-1261　2020/11
Publisher: (株)メディカ出版
ISSN： 0917-1495

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てんかんに対する遠隔外来と包括的入院精査の相補的利用の有用性について検討した。テレビ会議システムによる遠隔てんかん外来を初診した患者32名(男性24例、女性8例、13〜75歳)を対象とした。32例中23例において遠隔てんかん外来で診断精度が向上し、具体的にはてんかんか否かの診断の確定が9例、てんかんという診断で焦点性か全般性かが鑑別できたものが9例、焦点てんかんでさらなる部位診断が確定したのが5例であった。遠隔てんかん外来で診断精度が向上した23例中5例で包括的精査入院が行われ、3例でさらに診断精度が向上した。遠隔てんかん外来で診断精度が向上しなかった9例中5例で包括的精査入院が行われ、遠隔てんかん外来の診断が包括的精査入院で変更された。遠隔てんかん外来で診断精度が向上しており、有用性があらためて確認された。
超選択的Wada testによるオーダーメイド的局所脳機能評価

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 浅黄優, 中里信和, 冨永悌二

臨床神経生理学　48　(5)　363-363　2020/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
拡大するてんかんの遠隔医療てんかん診療における遠隔外来と包括的入院精査の相補的利用

柿坂庸介, 大沢伸一郎, 成田徳雄, 神一敬, 冨永悌二, 中里信和

臨床神経生理学　48　(5)　491-491　2020/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
Revisional Analysis of Electroencephalography and Magnetoencephalography Based on Comprehensive Epilepsy Conference

Nobukazu Nakasato, Akitake Kanno, Makoto Ishida, Shin-ichiro Osawa, Masaki Iwasaki, Yosuke Kakisaka, Kazutaka Jin

Fifty Years of Magnetoencephalography　191-197　2020/09/11
Publisher: Oxford University Press
DOI： 10.1093/oso/9780190935689.003.0013 　

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This chapter highlights the importance of the revised analysis of electroencephalography (EEG) and magnetoencephalography (MEG) spike source estimation based on comprehensive case conference discussion. It discusses two typical cases of localization-related epilepsy: case 1 as a simple situation and case 2 as a complicated situation. No “gold standard” for epileptic spike analysis in EEG or MEG has been established, so several methods must be adopted to achieve the most reasonable interpretation. However, such intense and revisional analyses may be too time-consuming in clinical settings and result in arbitrary conclusions. Therefore, the authors currently use a simple method first, that is, a single dipole model for the peak or preceding upward slope of unaveraged single spikes. In the following case conference, EEG and MEG data are reviewed with seizure semiology, anatomical magnetic resonance imaging (MRI), and ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET). If all the findings almost agree, the clinical decision can be easily made. If not, revisional analysis of EEG/MEG is recommended using averaged spikes and principal component analysis models as well as distributed source models. In addition to EEG/MEG, the authors often order revisional analysis and additional MRI and FDG-PET studies after the conference. Even further history taking will be recommended if necessary.
左側頭後頭葉底面の皮質電気刺激により顔の幻視とパレイドリアを呈した1例 Peer-reviewed

細川大瑛, 柿沼一雄, 上利大, 浮城一司, 佐藤貴文, 大沢伸一郎, 神一敬, 中里信和, 富永悌二, 鈴木匡子

高次脳機能研究　40　(1)　63-64　2020/03
Publisher: (一社)日本高次脳機能障害学会
ISSN： 1348-4818

eISSN： 1880-6554
Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy. Peer-reviewed

Masashi Chonan, Ryuta Saito, Masayuki Kanamori, Shin-Ichiro Osawa, Mika Watanabe, Hiroyoshi Suzuki, Nobukazu Nakasato, Teiji Tominaga

Neurologia medico-chirurgica　60　(1)　37-44　2020/01/15

DOI： 10.2176/nmc.oa.2018-0245 　

ISSN： 0470-8105

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After introduction of levetiracetam (LEV), treatment of seizures in patients with malignant brain tumors has prominently improved. On the other hand, we still experience some cases with LEV-uncontrollable epilepsy. Perampanel (PER) is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoaxazolepropionate acid receptor antagonist that has recently been approved for treating focal epilepsy as a secondary drug of choice. Available literature reporting PER medication in patients with gliomas is still sparse. Here, we report our initial experience with glioma patients and report efficacy of adding low dose 2-4 mg PER to LEV in patients whose seizure were uncontrollable with LEV monotherapy. Clinical outcome data of 18 consecutive patients were reviewed. This included nine males and nine females aged 24-76 years (median, 48.5 years), treated for glioma between June 2009 to December 2018. We added PER to patients with LEV-uncontrollable epilepsy. Adverse effects, irritability occurred in two patients, but continuous administration was possible in all cases. Though epileptic seizures occurred in four cases receiving 2 mg PER, 17 cases achieved seizure freedom by dose increments; final dose, 2-4 mg PER added to LEV 500-3000 mg. Our study revealed anti-epileptic efficacy of low dose PER 2-4 mg as first add-on therapy to LEV in glioma patients who have failed or intolerable to LEV monotherapy. Low dose PER added on to LEV may have favorable efficacy with tolerable adverse effects in glioma patients with LEV-uncontrollable epilepsy.
発作時に気分高揚を示唆する言動を呈した右内側側頭葉てんかんの一例 Peer-reviewed

土屋真理夫, 神一敬, 柿坂庸介, 大沢伸一郎, 上利大, 浮城一司, 中里信和

てんかん研究　37　(3)　844-844　2020/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Efficacy of intra-arterial indocyanine green angiography for the microsurgical treatment of dural arteriovenous fistula: A case report. International-journal Peer-reviewed

Keisuke Sasaki, Hidenori Endo, Kuniyasu Niizuma, Yasuo Nishijima, Shinichiro Osawa, Miki Fujimura, Teiji Tominaga

Surgical neurology international　11　46-46　2020

DOI： 10.25259/SNI_588_2019 　

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Background: In this study, we report a case of dural arteriovenous fistula (dAVF) that was successfully treated using intra-arterial indocyanine green (IA-ICG) videoangiography during open surgery. Moreover, the findings of IA-ICG videoangiography were compared with those of intraoperative digital subtraction angiography (DSA). Case Description: A 72-year-old male patient with a history of hypertension, hyperlipidemia, and thrombocytosis presented with generalized seizure. DSA revealed Cognard Type III dAVF in the superior wall of the left transverse sinus, which was fed by a single artery (the left occipital artery [OA]) and drained into a single vein (the left temporal cortical vein), without drainage into a venous sinus. Since transarterial embolization was considered challenging due to the tortuosity of the left OA, surgical interruption of the shunt was performed by craniotomy. After excising the feeding artery, we were unable to observed dAVF on intraoperative DSA. However, IA-ICG videoangiography revealed the remaining shunt, which was fed by the collateral route from the feeding artery. The shunting point and draining vein were then surgically resected to eliminate the shunt. The shunt was not observed during the second IA-ICG videoangiography conducted after resection. Conclusion: ICG videoangiography is a better method compared with DSA in terms of visualizing fine vascular lesions. In contrast to the typical intravenous administration, selective IA-ICG can be repeatedly injected at a minimal dose. IA-ICG is a useful intraoperative tool that can be used to evaluate the elimination of the dAVF.
超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価 Peer-reviewed

大沢伸一郎, 鈴木匡子, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 斎藤竜太, 金森政之, 中里信和, 冨永悌二

脳血管内治療　4　(Suppl.)　S383-S383　2019/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
てんかん外科に必要な術中マッピング超選択的Wada testによるオーダーメイド的脳機能評価 Peer-reviewed

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 浅黄優, 新妻邦泰, 三木俊, 神一敬, 中里信和, 冨永悌二

臨床神経生理学　47　(5)　358-358　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例 Peer-reviewed

菅野彰剛, 神一敬, 大沢伸一郎, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 佐藤志帆, 麦倉俊司, 中里信和

臨床神経生理学　47　(5)　436-436　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
持続脳波モニタリングを用いた非けいれん性てんかん重積の診断過程 Peer-reviewed

上利大, 神一敬, 大沢伸一郎, 川副友, 浅黄優, 中里信和

臨床神経生理学　47　(5)　457-457　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
てんかん関連脳磁図東北大学における最新の知見 Peer-reviewed

菅野彰剛, 神一敬, 柿坂庸介, 上利大, 石田誠, 大沢伸一郎, 中里信和

てんかん研究　37　(2)　462-462　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
高齢症例の脳梁離断術における術式選択と術後転帰の検討 Peer-reviewed

浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 山本哲哉, 冨永悌二, 中里信和

てんかん研究　37　(2)　656-656　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
超選択的Wada testによるオーダーメイド的脳機能評価 Peer-reviewed

大沢伸一郎, 鈴木匡子, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 中里信和, 冨永悌二

てんかん研究　37　(2)　693-693　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
脳磁図の再評価とさらなる発展を目指して電流双極子によるてんかん波形の解釈てんかん診療における脳磁図の役割と電流双極子モデルの意味 Peer-reviewed

柿坂庸介, 神一敬, 北澤悠, 上利大, 高山裕太郎, 大沢伸一郎, 菅野彰剛, 中里信和

日本生体磁気学会誌　31　(1)　42-43　2018/06
Publisher: 日本生体磁気学会
ISSN： 0915-0374
[A Case of Hypertrophic Pachymeningitis with Symptomatic Venous Congestion due to Sinus Stenosis]. Peer-reviewed

Sho Umegaki, Shin-Ichiro Osawa, Kensuke Kimura, Toshimi Okushima, Nobuhisa Yajima, Tsuyoshi Kawamura, Teiji Tominaga

No shinkei geka. Neurological surgery　46　(2)　147-152　2018/02
Publisher:
DOI： 10.11477/mf.1436203691 　

ISSN： 0301-2603

eISSN： 1882-1251

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We report a patient with hypertrophic pachymeningitis and symptomatic stenosis of the superior sagittal sinus. A 71-year-old man presented with right hemiparesis, sensory-dominant aphasia, and right hemispatial neglect that had been worsening over 2 weeks. Computed tomography showed isodense crescent-shaped lesions deforming the surface of the left cerebral hemisphere, mimicking a subdural hematoma with atypical perifocal edema in the left parietal lobe. Magnetic resonance imaging showed diffuse thickening of the dura mater with contrast enhancement of his left cerebral hemisphere. Histopathological examination of the dural specimen obtained by burr-hole surgery revealed mononuclear inflammatory cell infiltration, and he was diagnosed with hypertrophic pachymeningitis. Dynamic cerebral angiography showed superior sagittal sinus stenosis with reduced venous flow through the left parietal lobe. Administration of high-dose steroid therapy led to neurological improvement. In the case of a subdural mass with atypical parenchymal edema such as a chronic subdural hematoma, other etiology should be taken into consideration.
Surgical treatment of intractable epilepsy presenting with hyperkinetic seizures originating in the frontal lobe

Shin-Ichiro Osawa, Masaki Iwasaki, Yutaro Takayama, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Japanese Journal of Neurosurgery　27　(10)　764-772　2018
Publisher: Japanese Congress of Neurological Surgeons
DOI： 10.7887/jcns.27.764 　

ISSN： 0917-950X

eISSN： 2187-3100
Current Status of Epilepsy Surgery in Adults Peer-reviewed

Shin-Ichiro Osawa, Masaki Iwasaki, Teiji Tominaga

Brain and nerve　69　(10)　1105-1113　2017/10
Publisher:
DOI： 10.11477/mf.1416200878 　

ISSN： 1881-6096

eISSN： 1344-8129

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Epilepsy surgery is an effective way to control seizures in patients with refractory epilepsy, even in patients in whom drug therapy has not resulted in adequate seizure control. Many studies support the efficacy and safety of resective and non-resective surgeries for the treatment of refractory epilepsy in appropriately selected individuals. However, it is sometimes argued that epilepsy surgery is underutilized despite the evidence and guidelines supporting its use. Among the causes cited for underutilization of this treatment are numerous barriers to epilepsy surgery. Further strategies are needed to increase access to surgery and to improve communication about the effectiveness of this potentially life-changing procedure. In addition, epilepsy surgery is only one part of the multimodal treatment of refractory epilepsy. A comprehensive approach is required to address the medical, surgical, psychosocial, rehabilitation and moral needs of patients with epilepsy in order to improve their quality of life.
Subcortical band heterotopiaを伴う難治てんかんに対し脳梁離断術を行った3例

大沢伸一郎, 岩崎真樹, 下田由輝, 神一敬, 柿坂庸介, 植松貢, 萩野谷和裕, 中里信和, 冨永悌二

てんかん研究　34　(2)　466-466　2016/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
東日本大震災後のてんかんの発症状況

柴原一陽, 大沢伸一郎, 中里信和, 冨永悌二, 成田徳雄

臨床神経学　55　(Suppl.)　S40-S40　2015/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
定位放射線治療後の薬剤難治性てんかんに対する外科治療

大沢伸一郎, 岩崎真樹, 下田由輝, 神一敬, 柿坂庸介, 中里信和, 川岸潤, 城倉英史, 冨永悌二

てんかん研究　33　(2)　494-494　2015/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Outflow Occlusion with Occipital Artery-Posterior Inferior Cerebellar Artery Bypass for Growing Vertebral Artery Fusiform Aneurysm with Ischemic Onset: A Case Report. International-journal Peer-reviewed

Ryuzaburo Kochi, Hidenori Endo, Miki Fujimura, Kenichi Sato, Shin-ichiro Sugiyama, Shin-ichiro Osawa, Teiji Tominaga

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　24　(8)　e223-6-E226　2015/08

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.020 　

ISSN： 1052-3057

eISSN： 1532-8511
Ruptured Cerebral Microaneurysm Diagnosed by 3-Dimensional Fast Spin-Echo T1 Imaging with Variable Flip Angles. International-journal Peer-reviewed

Hidenori Endo, Kuniyasu Niizuma, Miki Fujimura, Kenichi Sato, Takashi Inoue, Shin-Ichiro Osawa, Teiji Tominaga

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association　24　(8)　e231-5-E235　2015/08

DOI： 10.1016/j.jstrokecerebrovasdis.2015.04.031 　

ISSN： 1052-3057

eISSN： 1532-8511
Interhemispheric Vertical Hemispherotomy: A Single Center Experience. International-journal Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Shin-Ichiro Osawa, Yoshiteru Shimoda, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Pediatric neurosurgery　50　(5)　295-300　2015

DOI： 10.1159/000437145 　

ISSN： 1016-2291

eISSN： 1423-0305
[Efficacy of halo-vest fixation in the assessment and prediction of the effectiveness of permanent fixation in a patient with basilar invagination with ambiguous vertebral instability]. Peer-reviewed

Shin-ichiro Osawa, Shinsuke Suzuki, Toru Sasaki, Masayuki Kanamori, Hiroshi Uenohara

No shinkei geka. Neurological surgery　42　(10)　931-5　2014/10
Publisher: Igaku-Shoin Ltd
DOI： 10.11477/mf.1436200007 　

ISSN： 1882-1251 0301-2603

eISSN： 1882-1251
Time-varying inter-hemispheric coherence during corpus callosotomy. International-journal Peer-reviewed

Eiichi Okumura, Masaki Iwasaki, Rie Sakuraba, Izumi Itabashi, Shin-ichiro Osawa, Kazutaka Jin, Hisashi Itabashi, Kazuhiro Kato, Akitake Kanno, Teiji Tominaga, Nobukazu Nakasato

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology　124　(11)　2091-100　2013/11

DOI： 10.1016/j.clinph.2013.05.004 　

ISSN： 1388-2457

eISSN： 1872-8952
Parental satisfaction and seizure outcome after corpus callosotomy in patients with infantile or early childhood onset epilepsy. International-journal Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Tojo Nakayama, Naomi Hino-Fukuyo, Yuko Sato, Tomoko Kobayashi, Kazuhiro Haginoya, Shin-Ichiro Osawa, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Seizure　22　(4)　303-5　2013/05

DOI： 10.1016/j.seizure.2013.01.005 　

ISSN： 1059-1311
Intra-operative Monitoring of Inter-hemispheric EEG Connectivity During Corpus Callosotomy Peer-reviewed

Iwasaki Masaki, Okumura Eiichi, Sakuraba Rie, Itabashi Izumi, Osawa Shin-ichiro, Jin Kazutaka, Nakasato Nobukazu, Tominaga Teiji

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY　91　43　2013

ISSN： 1011-6125
Complete remission of seizures after corpus callosotomy. International-journal Peer-reviewed

Masaki Iwasaki, Mitsugu Uematsu, Yuko Sato, Tojo Nakayama, Kazuhiro Haginoya, Shin-ichiro Osawa, Hisashi Itabashi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga

Journal of neurosurgery. Pediatrics　10　(1)　7-13　2012/07

DOI： 10.3171/2012.3.PEDS11544 　

ISSN： 1933-0707
Infratentorial brain metastases of pediatric non-epithelial malignant tumors: three case reports. Peer-reviewed

Shin-ichiro Osawa, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Hidetaka Niizuma, Mika Watanabe, Teiji Tominaga

Brain tumor pathology　28　(2)　167-74　2011/04

DOI： 10.1007/s10014-010-0014-0 　

ISSN： 1433-7398

eISSN： 1861-387X
稀な小児頭蓋外発生肉腫の頭蓋内転移2症例 Peer-reviewed

大沢伸一郎, 隈部俊宏, 齋藤竜太, 園田順彦, 冨永悌二, 渡辺みか, 新妻秀剛

小児がん　48　(1)　34-35　2011
Publisher:
ISSN： 0389-4525
稀な小児頭蓋外発生肉腫の頭蓋内転移2症例 Peer-reviewed

大沢伸一郎, 隈部俊宏, 齋藤竜太, 園田順彦, 渡辺みか, 新妻秀剛, 冨永悌二

Brain Tumor Pathology　27　(Suppl.)　118-118　2010/05
Publisher:
ISSN： 1433-7398

eISSN： 1861-387X
A comparison of human observers and a channelized hotelling observer in discriminating between Alzheimer's dementia and controls using brain perfusion SPECT Peer-reviewed

Miho Shidahara, Kentaro Inoue, Masahiro Maruyama, Yasuyuki Taki, Ryoi Goto, Ken Okada, Shinichiro Osawa, Shigeo Kinomura, Hiroshi Ito, Hiroyuki Arai, Hiroshi Fukuda

2005 IEEE Nuclear Science Symposium Conference Record, Vols 1-5　2148-2149　2005

ISSN： 1082-3654

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Misc. 198

選択的脳領域麻酔による新規機能マッピング法の確立

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 新妻邦泰, 新妻邦泰, 新妻邦泰, 神一敬, 遠藤英徳

臨床神経生理学(Web)　53　(5)　2025

ISSN： 2188-031X
Surgical approach to insulo-opercular epilepsy: insights from functional risk assessment

大沢伸一郎, 浮城一司, 柿沼一雄, 石田誠, 菊地花, 下田由輝, 神一敬, 植松貢, 鈴木匡子, 遠藤英徳

てんかん研究　43　(2)　2025

ISSN： 0912-0890
Selectvie Anesthesia for Functional Evaluation (SAFE) with application of endovascular treatment techniques in epilepsy surgery

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 太田祥子, 下田由輝, 金森政之, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 神一敬, 遠藤英徳

てんかん研究　43　(2)　2025

ISSN： 0912-0890
Effects of remimazolam on electrocorticography and motor evoked potential in patients with temporal lobe epilepsy

浮城一司, 大沢伸一郎, 鎌田ことえ, 佐藤貴文, 山内正憲, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025
Bilateral and asymmetrical localization of language function identified by the superselective infusion of propofol in an occipitotemporal epilepsy patient successfully treated by resection of two remote area

二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 鈴木博義, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　48th　2025
Multimodal brain function risk assessment with application of endovascular treatment techniques in epilepsy surgery

大沢伸一郎, 鈴木匡子, 柿沼一雄, 菊地花, 浮城一司, 石田誠, 勝瀬一登, 金森政之, 下田由輝, 二宮敦彦, 太田祥子, 新妻邦泰, 新妻邦泰, 新妻邦泰, 松本康史, 松本康史, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　48th　2025
Assessment of memory lateralization by PCA selective anesthesia can predict postoperative verbal memory decline

菊地花, 大沢伸一郎, 柿沼一雄, 勝瀬一登, 勝瀬一登, 太田祥子, 浮城一司, 神一敬, 遠藤英徳, 中里信和, 鈴木匡子

日本てんかん外科学会プログラム・抄録集　48th　2025
Diagnostic value of relationship between epileptogenic zone and the frequency change of epileptic spike during selective anesthesia by super-selective infusion of propofol to intracranial artery

石田誠, 大沢伸一郎, 菊地花, 浮城一司, 神一敬, 鈴木匡子, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025
Clinical presentation of new-onset psychogenic nonepileptic seizures after epilepsy surgery

小川舞美, 大沢伸一郎, 岩城弘隆, 秋月祐子, 藤川真由, 浮城一司, 下田由輝, 神一敬, 富田博秋, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　48th　2025
10-10電極配置法に則った追加脳波電極が発作時脳波変化の検出に有用であった一例

坂本美佳, 神一敬, 此松和俊, 此松和俊, 大沢伸一郎, 浮城一司, 浅黄優, 三木俊, 中里信和

全国てんかんセンター協議会総会プログラム・抄録集　12th　2025
てんかん焦点切除後に書字への関心が顕著となった自閉症スペクトラムの一例

柿沼一雄, 大沢伸一郎, 曽我天馬, 浮城一司, 神一敬, 勝瀬一登, 勝瀬一登, 森田亜由美, 遠藤佳子, 遠藤英徳, 中里信和, 鈴木匡子

日本神経精神医学会学術集会プログラム・抄録集　29th (CD-ROM)　2024
左側頭葉新皮質病変を伴うてんかんにおける発作時心拍上昇率の比較

高野歩有, 浮城一司, 曽我天馬, 神一敬, 板橋泉, 大沢伸一郎, 大沢伸一郎, 岩崎真樹, 遠藤英徳, 中里信和

臨床神経生理学(Web)　52　(5)　2024

ISSN： 2188-031X
後大脳動脈への超選択的麻酔薬注入による記憶機能のカテゴリ別評価

大沢伸一郎, 鈴木匡子, 柿沼一雄, 勝頼一登, 菊地花, 浮城一司, 石田誠, 新妻邦泰, 新妻邦泰, 神一敬, 中里信和, 遠藤英徳

日本ヒト脳機能マッピング学会プログラム・抄録集　26th　2024
Verification for safety and efficacy of hydrogel-based organic electrode by physician-initiated clinical trial

大沢伸一郎, 新妻邦泰, 中川敦寛, 新妻邦泰, 中川敦寛, 浮城一司, 下田由輝, 神一敬, 植松貢, 岩崎真樹, 西澤松彦, 中里信和, 冨永悌二, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　47th　2024
Association between postoperative neuroimaging and motor dysfunction in peri-rolandic epilepsy after focal cortical resection

二宮敦彦, 大沢伸一郎, 鈴木匡子, 柿沼一雄, 浮城一司, 下田由輝, 鈴木博義, 宮田元, 神一敬, 植松貢, 中里信和, 遠藤英徳

日本てんかん外科学会プログラム・抄録集　47th　2024
Efficacy of complete callosotomy in a case of sound-induced generalized tonic seizures

浮城一司, 大沢伸一郎, 柿坂庸介, 神一敬, 冨永悌二, 遠藤英徳, 中里信和

日本てんかん外科学会プログラム・抄録集　47th　2024
視覚関連領域および聴覚関連領域におけるつなぎ言葉関連皮質高ガンマ変調

木村りり, 北澤悠, 北澤悠, 比企野理咲, 山岸菖, 宇田裕史, 黒田直生人, 宇田裕史, 黒田直生人, 飯島圭哉, 大沢伸一郎, 大沢伸一郎, 鈴木匡子, 中里信和, 岩崎真樹, 浅野英司, 浅野英司

高次脳機能研究　44　(1)　2024

ISSN： 1348-4818
運動感覚皮質領域で認められるつなぎ言葉関連高ガンマ変調

比企野理咲, 北澤悠, 北澤悠, 木村りり, 山岸菖, 宇田裕史, 黒田直生人, 宇田裕史, 黒田直生人, 飯島圭哉, 大沢伸一郎, 大沢伸一郎, 鈴木匡子, 中里信和, 岩崎真樹, 浅野英司, 浅野英司

高次脳機能研究　44　(1)　2024

ISSN： 1348-4818
左下前頭回におけるつなぎ言葉関連皮質高ガンマ変調

山岸菖, 北澤悠, 北澤悠, 木村りり, 比企野理咲, 宇田裕史, 黒田直生人, 宇田裕史, 黒田直生人, 飯島圭哉, 大沢伸一郎, 大沢伸一郎, 鈴木匡子, 中里信和, 岩崎真樹, 浅野英司, 浅野英司

高次脳機能研究　44　(1)　2024

ISSN： 1348-4818
Decision-making assessment for epilepsy surgery using MacArthur Competence Assessment Tools by a Certified Psychologist

藤川真由, 藤川真由, 大沢伸一郎, 曽我天馬, 小川舞美, 高橋健人, 大友風佳, 本庄谷奈央, 柿坂庸介, 柿坂庸介, 神一敬, 神一敬, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　46th　2023
Development of hydrogel-based organic electrode for better bio-compatibility

大沢伸一郎, 西澤松彦, 中川敦寛, 岩崎真樹, 鈴木泰汎, 下田由輝, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　46th　2023
The Role of the Clinical Laboratory Technician in Epilepsy Surgery

石田誠, 大沢伸一郎, 神一敬, 柿坂庸介, 菅野彰剛, 浅黄優, 冨永悌二, 中里信和, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　46th　2023
問題症例のMEG 海馬硬化症を伴う左内側側頭葉てんかんにおけるMEGとfMRIによる言語左右差の不一致(Left mesial temporal epilepsy with hippocampal sclerosis showing discordance of language laterality between MEG and fMRI)

古知龍三郎, 神一敬, 石田誠, 菅野彰剛, 大沢伸一郎, 岩崎真樹, 冨永悌二, 中里信和

臨床神経生理学　50　(5)　344-344　2022/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
発作間欠期spike関連ripple解析を用いたてんかん原性部位の推定について

植松貢, 植松有里佳, 平田理絵, 大沢伸一郎, 神一敬, 岩崎真樹, 中里信和

臨床神経生理学　50　(5)　427-427　2022/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
脳波の読み方-up to date B.疾患別の脳波内側側頭葉てんかん

浮城一司, 大沢伸一郎

Clinical Neuroscience　40　(4)　2022

ISSN： 0289-0585
Respective contribution of depth and subdural electrode by craniotomy in epilepsy surgery

大沢伸一郎, 浮城一司, 鈴木匡子, 石田誠, 柿沼一雄, 植松貢, 下田由輝, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　45th　2022
Should we consider the indication of complete corpus callosotomy in cases with more than 10 years’ epilepsy duration?

浮城一司, 浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 山本哲哉, 冨永悌二, 中里信和

日本てんかん外科学会プログラム・抄録集　45th　2022
Concept of resective surgery for LEAT

大沢伸一郎, 浮城一司, 下田由輝, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

てんかん研究　40　(2)　2022

ISSN： 0912-0890
発作間欠期spike関連ripple解析を用いたてんかん原性部位の推定について

植松貢, 植松有里佳, 平田理絵, 大沢伸一郎, 神一敬, 岩崎真樹, 中里信和

臨床神経生理学(Web)　50　(5)　2022

ISSN： 2188-031X
皮質電気刺激によって誘発されたキネトプシア:側頭葉てんかん症例における検討

柿沼一雄, 大沢伸一郎, 浮城一司, 篠田元気, 細川大瑛, 親富祖まりえ, 太田祥子, 石田誠, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

日本神経化学会大会抄録集(Web)　65th　2022
Left mesial temporal epilepsy with hippocampal sclerosis showing discordance of language laterality between MEG and fMRI

古知龍三郎, 古知龍三郎, 神一敬, 石田誠, 菅野彰剛, 大沢伸一郎, 岩崎真樹, 冨永悌二, 中里信和

臨床神経生理学(Web)　50　(5)　2022

ISSN： 2188-031X
Utility of AI-based magnetoencephalography analysis in a case of frontal lobe epilepsy

菅野彰剛, 菅野彰剛, 大沢伸一郎, 神一敬, 柿坂庸介, 石田誠, 石田誠, 浮城一司, 曽我天馬, 此松和俊, 植松貢, 中田乙一, 長谷川史裕, 平田雅之, 冨永悌二, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　45th　2022
Magnetoencephalography for the preoperative diagnosis of insulo-opercular epilepsy: report of 2 cases

石田誠, 大沢伸一郎, 菅野彰剛, 柿坂庸介, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　45th　2022
頭蓋内動脈への超選択的麻酔薬注入による詳細な神経症状評価と手術適応への寄与

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
オンライン医学教育の意義と運用の実際-遠隔てんかん症例検討会の経験から-

柿坂庸介, 神一敬, 大沢伸一郎, 中里信和

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
Provocation test by super-selective infusion of propofol predicts post-surgical functional outcome.

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 新妻邦泰, 新妻邦泰, 下田由輝, 神一敬, 中里信和, 冨永悌二

脳血管内治療(Web)　6　(Supplement)　2021

ISSN： 2424-1709
脳磁図局在診断が有用であった弁蓋部と島の焦点てんかん2例

石田誠, 神一敬, 菅野彰剛, 大沢伸一郎, 柿坂庸介, 浮城一司, 冨永悌二, 中里信和, 中里信和

臨床神経生理学(Web)　49　(5)　2021

ISSN： 2188-031X
急性硬膜外血腫の術後に,硬膜外での被膜形成を伴う血腫再貯留を来した1例

三野正樹, 大沢伸一郎, 佐藤加奈子, ジャウェンティン, 下田由輝, 鹿毛淳史, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　44th　2021
高齢者脳実質内腫瘍における非痙攣性てんかん重積

金森政之, 大沢伸一郎, 下田由輝, 斎藤竜太, 冨永悌二

日本老年脳神経外科学会プログラム・抄録集　34th (CD-ROM)　2021
A Case of Cavernous Sinus Dural Arteriovenous Fistula Successfully Treated by Transarterial Embolization with Embosphere

CHEN Mengge, 大沢伸一郎, 新妻邦泰, 遠藤英徳, 冨永悌二

脳血管内治療(Web)　6　(1)　2021

ISSN： 2424-1709
Muse細胞を用いたてんかん原性治癒手法の確立

大沢伸一郎, 新妻邦泰, 新妻邦泰, 冨永悌二

てんかん治療研究振興財団研究年報　32　65-68　2021
Publisher: 大阪 : てんかん治療研究振興財団
ISSN： 0915-5902
左頭頂葉切除後に非典型的言語野分布を呈した脳腫瘍例:超選択的Wada testによる検討

柿沼一雄, 大沢伸一郎, 下田由輝, 金森政之, 浮城一司, 太田祥子, 親富祖まりえ, 川村藍, 冨永悌二, 中里信和, 鈴木匡子

日本神経心理学会学術集会プログラム予稿集　45th　2021
Development of Epilepsy after treating Germ cell tumor

下田由輝, 金森政之, 大沢伸一郎, 齋藤竜太, 園田順彦, 隈部俊宏, 中里信和, 冨永悌二

てんかん研究　39　(2)　2021

ISSN： 0912-0890
A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

日本生体医工学会大会プログラム・抄録集(Web)　60th　2021
Frontal lobe epilepsy with eye/head version in which MEG was useful to localize epileptic focus

土屋真理夫, 石田誠, 石田誠, 大沢伸一郎, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

日本生体医工学会大会プログラム・抄録集(Web)　60th　2021
Can scalp EEG findings predict seizure outcome after anterior temporal lobectomy in patients with MRI-negative FDG-PET-positive temporal lobe epilepsy?

曽我天馬, 曽我天馬, 神一敬, 大沢伸一郎, 岩崎真樹, 青木正志, 中里信和

てんかん研究　39　(2)　317-317　2021
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

日本生体医工学会大会プログラム・抄録集(Web)　60th　2021
A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

日本生体医工学会大会プログラム・抄録集(Web)　60th　2021
PENETRATING VERTEBRAL ARTERY INJURY TREATED BY ANGIOEMBOLIZATION UNDER MANUAL DIRECT PRESSURE HEMOSTASIS : A CASE REPORT

横川京子, 久志本成樹, 久志本成樹, 川副友, 川副友, 大沢伸一郎, 西嶌泰生, 冨永悌二

日本外傷学会雑誌(Web)　35　(3)　2021

ISSN： 2188-0190
Dispersion of debris during under water application of pulsed water jet device

影山宗祐, 中川敦寛, 中川敦寛, 川口奉洋, 大谷清伸, 大沢伸一郎, 遠藤俊毅, 冨永悌二

日本生体医工学会大会プログラム・抄録集(Web)　60th　(Abstract)　326-326　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.326 　

ISSN： 1347-443X

eISSN： 1881-4379

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Object. Pulsed water jet surgical instrumentation is intended to achieve both maximal lesion resection and functional maintenance through preservation of fine vessels and minimal surrounding damage. To proceed to clinical application in neuroendoscopic surgery, the aim of the present study was to develop the experimental set up to quantify the amount of debris dispersion under water application and to reduce the amount of debris.Methods. Brain phantom stained by methylene blue dye was dissected with ADPJ in the water. The net weight of brain phantom was calculated by spectrophotometer. The relationship between jet strength, suction rate, structure distance between suction tube and target, the effect of adding outer suction tube, and amount of dispersion was evaluated.Results. The net weight of dispersed debris could be measured by absorbance of methylene blue dye. The amount of dispersion decreased adding outer suction tube and increased the suction rate.
Efficacy of medical cooperation system in epilepsy-surgery clinic in Aomori

大沢伸一郎, 柿坂庸介, 浮城一司, 神一敬, 村上謙介, 川村強, 中里信和, 冨永悌二

てんかん研究　39　(2)　363-363　2021
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Age-related seizure outcome after one-stage complete corpus callosotomy

浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 植松貢, 山本哲哉, 冨永悌二, 中里信和

てんかん研究　39　(2)　341-341　2021
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
A case of frontal lobe epilepsy with focal aware seizures with eye and head version in which MEG was useful to localize epileptic focus.

土屋真理夫, 石田誠, 大沢伸一郎, 浮城一司, 柿坂庸介, 菅野彰剛, 菅野彰剛, 神一敬, 張替宗介, 中里信和, 中里信和

日本生体磁気学会誌　34　(1)　667-669　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.667 　

ISSN： 0915-0374

eISSN： 1881-4379

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AbstractWe present a case with left frontal lobe epilepsy with focal aware seizure with eyes and head version to the right. MRI suggested a focal cortical dysplasia (FCD) in the left pre-central sulcus. EEG showed no interictal spikes nor EEG change during habitual seizures. MEG detected interictal spikes without concurrent EEG spikes. Source of MEG spikes was estimated near the left frontal lesion. After resection of the left frontal lesion, the patient became seizure free. Histopathological diagnosis was FCD type II. In this case, MEG was helpful to construct a unitary hypothesis of the left frontal lobe epilepsy due to FCD.
A case of atypical somatotopy due to a peri-rolandic lesion predicted by evoked magnetic fields

石田誠, 柿坂庸介, 菅野彰剛, 大沢伸一郎, 浮城一司, 神一敬, 冨永悌二, 中里信和, 中里信和

日本生体磁気学会誌　34　(1)　670-671　2021
Publisher: Japanese Society for Medical and Biological Engineering
DOI： 10.11239/jsmbe.annual59.670 　

ISSN： 0915-0374

eISSN： 1881-4379

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Atypical somatosensory localization is often found in a case of focal cortical dysplasia (FCD). Here we report a 14-year-old female patient medically intractable epilepsy of right sensorimotor seizures and right hemiplegia. MRI revealed a peri-rolandic FCD in the left parietal lobe. Somatosensory evoked magnetic fields (SEFs) for posterior tibial nerve stimuli indicated normal somatotopy of the foot area. However, SEFs for the right median nerve indicated marked reduction of the early components. Equivalent current dipole of the first peak at around 25 ms was localized on the central sulcus. However, this hand area localization was adjacent to the foot area. After implantation of subdural electrodes, somatosensory evoked potentials for the right median nerve stimulus confirmed the abnormal somatotopy predicted by pre-operative SEFs.
Muse細胞を用いたてんかん原性治癒手法の確立

大沢伸一郎, 新妻邦泰, 冨永悌二

Medical Science Digest　46　(2)　124-126　2020/02
Publisher: (株)ニュー・サイエンス社
ISSN： 1347-4340
Muse細胞を用いたてんかん原性治癒手法の確立

大沢伸一郎, 新妻邦泰, 冨永悌二

Medical Science Digest　46　(2)　124-126　2020/02
Publisher: (株)ニュー・サイエンス社
ISSN： 1347-4340
目でみるてんかん Optogeneticsとてんかん研究 Peer-reviewed

大沢伸一郎, 大沢伸一郎, 冨永悌二, 冨永悌二

Epilepsy　14　(2)　76-79　2020
Publisher: 東京 : メディカルレビュー社
ISSN： 1882-1480
てんかん診療における遠隔外来と包括的入院精査の相補的利用

柿坂庸介, 大沢伸一郎, 成田徳雄, 神一敬, 冨永悌二, 中里信和

臨床神経生理学(Web)　48　(5)　2020

ISSN： 2188-031X
2 cases of prepontine cistern-3rd ventricle epidermoid cyst resected under endoscope with manual jet technique

新妻邦泰, 新妻邦泰, 新妻邦泰, 石田朋久, 大沢伸一郎, 遠藤英徳, 冨永悌二

日本神経内視鏡学会プログラム・抄録集　27th　2020
An adolescent case with intractable generalized epilepsy successfully treated with two-stage complete corpus callosotomy

浮城一司, 大沢伸一郎, 岩崎真樹, 山本哲哉, 冨永悌二, 中里信和

日本てんかん外科学会プログラム・抄録集　44th　2020
Epilepsy after treating Germ cell tumor

下田由輝, 金森政之, 大沢伸一郎, 大沢伸一郎, 齋藤竜太, 園田順彦, 隈部俊宏, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　44th　2020
Surgical indication and treatment strategy for the patients with epileptic foci in sensory-motor cortex

大沢伸一郎, 鈴木匡子, 浮城一司, 神一敬, 植松貢, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　44th　2020
Super-selective infusion of propofol to posterior cerebral artery predict post-operative macular sparing in the case of occipital lobe epilepsy with bilateral occipital injury

古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 金森政之, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　44th　2020
超選択的Wada testによるオーダーメイド的局所脳機能評価

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 新妻邦泰, 神一敬, 浅黄優, 中里信和, 冨永悌二

臨床神経生理学(Web)　48　(5)　2020

ISSN： 2188-031X
オーダーメイド的脳機能評価における超選択的Wada testの有用性

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　43rd　2020
放線方向を主たる活動とした“bottom of sulcus”を呈する皮質形成異常前頭葉てんかん1症例への脳磁図を用いた解析

菅野彰剛, 神一敬, 大沢伸一郎, 石田誠, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 冨永悌二, 中里信和

日本てんかん外科学会プログラム・抄録集　43rd　2020
15歳以上の難治てんかんに対する全脳梁離断術の有効性について

浮城一司, 大沢伸一郎, 岩崎真樹, 山本哲哉, 冨永悌二, 中里信和

日本てんかん外科学会プログラム・抄録集　43rd　2020
超選択的Wada test時に発作と同様の症状を呈した2例

古知龍三郎, 大沢伸一郎, 鈴木匡子, 浮城一司, 上利大, 柿沼一雄, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　43rd　2020
深部電極による機能マッピングで証明された中心溝深部の運動機能局在

下田由輝, 下田由輝, 大沢伸一郎, 浮城一司, 上利大, 柿沼一雄, 古知龍三郎, 神一敬, 鈴木匡子, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　43rd　2020
左側中側頭回後方の皮質電気刺激により特徴的な幻聴を呈した1例

浮城一司, 大沢伸一郎, 柿沼一雄, 細川大瑛, 佐藤貴文, 冨永悌二, 鈴木匡子, 中里信和

日本ヒト脳機能マッピング学会プログラム・抄録集　22nd　2020
Order-made evaluation of brain function by super-selective Wada test in the candidate patients of epilepsy surgery

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 新妻邦泰, 神一敬, 中里信和, 冨永悌二

日本ヒト脳機能マッピング学会プログラム・抄録集　22nd　2020
頭蓋内脳波を用いた発作間欠時spike関連ガンマ活動潜時の検討

植松貢, 植松有里佳, 大沢伸一郎

てんかん研究　37　(3)　842-842　2020/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Utility of somatosensory evoked magnetic fields for lip stimulation: An epilepsy case with right paracentral lobule focal cortical dysplasia

菅野彰剛, 神一敬, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 石田誠, 大沢伸一郎, 冨永悌二, 中里信和, 中里信和

日本生体磁気学会誌　33　(1)　108-110　2020
Publisher: 日本生体磁気学会
ISSN： 0915-0374
発作時に気分高揚を示唆する言動を呈した右内側側頭葉てんかんの一例

土屋真理夫, 神一敬, 柿坂庸介, 大沢伸一郎, 上利大, 浮城一司, 中里信和

てんかん研究　37　(3)　844-844　2020/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
軽症頭部外傷の睡眠障害東北大学病院TBIクリニックの受傷から1年間の後方視的調査

佐久間篤, 八木橋真央, 中川敦寛, 麦倉俊司, 内海裕介, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

総合病院精神医学　31　(Suppl.)　S-195　2019/11
Publisher: (一社)日本総合病院精神医学会
ISSN： 0915-5872
三叉神経根近傍の脳幹脳動静脈奇形に対する塞栓術の治療成績

遠藤英徳, 松本康史, 佐藤健一, 大沢伸一郎, 藤村幹, 新妻邦泰, 冨永悌二

脳血管内治療　4　(Suppl.)　S199-S199　2019/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価

大沢伸一郎, 鈴木匡子, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 斎藤竜太, 金森政之, 中里信和, 冨永悌二

脳血管内治療　4　(Suppl.)　S383-S383　2019/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
遠隔てんかん症例検討会いかにテレビ会議システムの教育的効果を最大化させるか

柿坂庸介, 神一敬, 上利大, 土屋真理夫, 浮城一司, 大沢伸一郎, 中里信和

日本遠隔医療学会学術大会プログラム・抄録集　23回　84-84　2019/10
Publisher: (一社)日本遠隔医療学会
てんかん外科に必要な術中マッピング超選択的Wada testによるオーダーメイド的脳機能評価

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 浅黄優, 新妻邦泰, 三木俊, 神一敬, 中里信和, 冨永悌二

臨床神経生理学　47　(5)　358-358　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

菅野彰剛, 神一敬, 大沢伸一郎, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 佐藤志帆, 麦倉俊司, 中里信和

臨床神経生理学　47　(5)　436-436　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
持続脳波モニタリングを用いた非けいれん性てんかん重積の診断過程

上利大, 神一敬, 大沢伸一郎, 川副友, 浅黄優, 中里信和

臨床神経生理学　47　(5)　457-457　2019/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
高齢症例の脳梁離断術における術式選択と術後転帰の検討

浮城一司, 大沢伸一郎, 岩崎真樹, 柿坂庸介, 神一敬, 山本哲哉, 冨永悌二, 中里信和

てんかん研究　37　(2)　656-656　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
超選択的Wada testによるオーダーメイド的脳機能評価

大沢伸一郎, 鈴木匡子, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 中里信和, 冨永悌二

てんかん研究　37　(2)　693-693　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
てんかん関連脳磁図東北大学における最新の知見

菅野彰剛, 神一敬, 柿坂庸介, 上利大, 石田誠, 大沢伸一郎, 中里信和

てんかん研究　37　(2)　462-462　2019/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890
Tele-epilepsy conference : How we can maximize an educational effect of teleconference system Peer-reviewed

15　(2)　127-129　2019/09
Publisher: 日本遠隔医療学会
ISSN： 1880-800X
頭部外傷受傷者に対する東北大学病院精神科リエゾンチームの取り組み

佐久間篤, 八木橋真央, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

精神神経学雑誌　(2019特別号)　S764-S764　2019/06
Publisher: (公社)日本精神神経学会
ISSN： 0033-2658
椎骨動脈損傷を伴う頸部切創に対して、椎骨動脈塞栓術を実施して救命し得た1症例

横川京子, 川副友, 大沢伸一郎, 西嶌泰生, 藤田基生, 久志本成樹

日本外傷学会雑誌　33　(2)　239-239　2019/05
Publisher: (一社)日本外傷学会
ISSN： 1340-6264
スポーツ神経外傷の課題と対応学校における脳振盪教育現場の実情と課題

中川敦寛, 刈部博, 荻野雅宏, 八木橋真央, 中山晴雄, 望月浩一郎, 佐久間篤, 大沢伸一郎, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　66-66　2019/02
Publisher: (一社)日本脳神経外傷学会
頭部外傷後の患者への精神科介入判断に関する考察質と量的データの関連から

八木橋真央, 佐久間篤, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02
Publisher: (一社)日本脳神経外傷学会
脳神経外傷の画像診断びまん性軸索損傷の診断に関する来院時CTの意義

中川敦寛, 麦倉俊司, 今井啓道, 八木橋真央, 佐久間篤, 大沢伸一郎, 工藤大介, 刈部博, 近田祐介, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02
Publisher: (一社)日本脳神経外傷学会
スポーツ神経外傷の課題と対応学校における脳振盪教育現場の実情と課題

中川敦寛, 刈部博, 荻野雅宏, 八木橋真央, 中山晴雄, 望月浩一郎, 佐久間篤, 大沢伸一郎, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　66-66　2019/02
Publisher: (一社)日本脳神経外傷学会
頭部外傷後の患者への精神科介入判断に関する考察質と量的データの関連から

八木橋真央, 佐久間篤, 中川敦寛, 麦倉俊司, 古谷桂子, 工藤大介, 大沢伸一郎, 久志本成樹, 冨永悌二, 富田博秋

日本脳神経外傷学会プログラム・抄録集　42回　115-115　2019/02
Publisher: (一社)日本脳神経外傷学会
脳神経外傷の画像診断びまん性軸索損傷の診断に関する来院時CTの意義

中川敦寛, 麦倉俊司, 今井啓道, 八木橋真央, 佐久間篤, 大沢伸一郎, 工藤大介, 刈部博, 近田祐介, 冨田博秋, 久志本成樹, 冨永悌二

日本脳神経外傷学会プログラム・抄録集　42回　61-61　2019/02
Publisher: (一社)日本脳神経外傷学会
持続脳波モニタリングを用いた非けいれん性てんかん重積の診断過程

上利大, 神一敬, 神一敬, 大沢伸一郎, 川副友, 浅黄優, 中里信和, 中里信和, 中里信和

臨床神経生理学(Web)　47　(5)　2019

ISSN： 2188-031X
言語優位半球下前頭回深部の電気刺激による音認知の変容

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 古知龍三郎, 神一敬, 中里信和, 冨永悌二

日本ヒト脳機能マッピング学会プログラム・抄録集　21st　2019
超選択的Wada testによるオーダーメイド的脳機能評価

大沢伸一郎, 鈴木匡子, 浮城一司, 柿沼一雄, 上利大, 浅黄優, 新妻邦泰, 三木俊, 神一敬, 中里信和, 中里信和, 冨永悌二

臨床神経生理学(Web)　47　(5)　2019

ISSN： 2188-031X
MR画像異常指摘できず脳磁図信号源推定後に異常を指摘できた頭頂葉弁蓋部てんかん例

菅野彰剛, 神一敬, 大沢伸一郎, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 佐藤志帆, 麦倉俊司, 中里信和, 中里信和

臨床神経生理学(Web)　47　(5)　2019

ISSN： 2188-031X
超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価

大沢伸一郎, 鈴木匡子, 新妻邦泰, 新妻邦泰, 浮城一司, 柿沼一雄, 上利大, 神一敬, 斎藤竜太, 金森政之, 中里信和, 冨永悌二

脳血管内治療(Web)　4　(Supplement)　2019

ISSN： 2424-1709
Usefulness of Goreisan in Acute Phase Management of Intracerebral Hemorrhage Patients during Hemodialysis

KAWAMURA Tsuyoshi, OSAWA Shin-ichiro, SUZUKI Ichiro, HARA Kazushi

Surgery for Cerebral Stroke　47　(6)　439-443　2019
Publisher: The Japanese Society on Surgery for Cerebral Stroke
DOI： 10.2335/scs.47.439 　

ISSN： 0914-5508

eISSN： 1880-4683

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Hemodialysis in patients with intracerebral hemorrhage may cause dialysis disequilibrium syndrome, in which severe brain edema occurs due to the osmotic gradient resulting in a sudden rise in brain pressure. Based on our recent findings, we report the utility of Goreisan administration for the management of these conditions, i.e., prevention of increased brain pressure and exacerbation of brain edema during hemodialysis.Goreisan was administered 30 minutes prior to dialysis. The dose was adjusted according to the hematoma size and the degree of brain edema. All 17 patients completed acute phase dialysis and were either transferred to other hospitals or discharged. Three representative cases are reported herein.The first patient was a 77-year-old woman admitted to the hospital for right thalamic hemorrhage and intraventricular rupture. After stereotactic hematoma aspiration had been performed, increased blood pressure, tachypnea, and anisocoria appeared at the first postoperative dialysis session. We attributed this to a sudden increase in brain pressure, but a crisis was prevented by the administration of an osmotic diuretic. Considering that her condition was disequilibrium syndrome, saireito, a combination of Goreisan and Sho-saiko-to, was administered 30 minutes prior to dialysis. This combination prevented the increase in brain pressure. The second patient was a 45-year-old man hospitalized for right brainstem hemorrhage with intraventricular hematoma. He was treated conservatively. Difficulties at the time of dialysis were prevented by administration of Goreisan prior to dialysis. The third patient was a 74-year-old man who was admitted to the hospital for right thalamus hemorrhage with intraventricular hematoma. His condition was complicated by acute hydrocephalus; therefore, ventricular drainage was performed. Pretreatment with Goreisan prevented a rise in brain pressure during dialysis. Hydrocephalus did not relapse even after drain removal.Goreisan is a representative treatment for sui disturbance and is considered to be an effective means of managing disequilibrium syndrome, which is an iatrogenic sui disturbance. Its mechanism of action is considered to involve aquaporin 4 in the cell membrane. Goreisan exerts an inhibitory effect on aquaporin 4 and thus may have inhibited the progression of brain edema by inhibiting the sudden transfer of water from the blood vessels to the brain due to the osmotic gradient induced by dialysis. Regarding the acute phase management of patients with intracerebral hemorrhage receiving hemodialysis, administration of Goreisan 30 minutes prior to dialysis is useful for preventing the exacerbation of brain edema.
Wada testの発展的手法により明らかになった非典型的な言語局在の症例

柿沼一雄, 大沢伸一郎, 菅野彰剛, 浮城一司, 上利大, 柿坂庸介, 神一敬, 冨永悌二, 中里信和, 鈴木匡子

日本ヒト脳機能マッピング学会プログラム・抄録集　21st　70　2019
海馬機能評価における選択的後大脳動脈Wada testの有用性

大沢伸一郎, 鈴木匡子, 岩崎真樹, 新妻邦泰, 佐藤健一, 松本康史, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　42nd　75　2019/01
脳梁離断術後の急性離断症状改善経過

浮城一司, 大沢伸一郎, 岩崎真樹, 神一敬, 山本哲哉, 冨永悌二, 中里信和

日本てんかん外科学会プログラム・抄録集　42nd　81　2019/01
脳磁図棘波の信号源推定に平均加算と空間フィルター法の併用が役立った前頭葉てんかんの1症例

菅野彰剛, 神一敬, 大沢伸一郎, 石田誠, 柿坂庸介, 上利大, 浮城一司, 土屋真理夫, 中里信和

日本生体磁気学会誌　32　(1)　114-115　2019
Publisher: 日本生体磁気学会
ISSN： 0915-0374
選択的後大脳動脈Wade testによる海馬機能評価

大沢伸一郎, 新妻邦泰, 鈴木匡子, 岩崎真樹, 佐藤健一, 遠藤英徳, 松本康史, 神一敬, 中里信和, 冨永悌二

脳血管内治療　3　(Suppl.)　S154-S154　2018/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
救急集中治療室における長時間ビデオ脳波モニタリングの役割

浅黄優, 大沢伸一郎, 中川敦寛, 中川敦寛, 中里信和, 中里信和, 冨永悌二, 久志本成樹

日本救急医学会雑誌　29　(10)　461-461　2018/10/15
Publisher: (一社)日本救急医学会
ISSN： 0915-924X
頭部外傷診療における救急医と脳神経外科医の役割頭部外傷クリニック脳振盪に対する対応の変化を踏まえた救急医と脳神経外科医の役割分担

中川敦寛, 富田博秋, 佐久間篤, 八木橋真央, 麦倉俊司, 大沢伸一郎, 刈部博, ジェフリー・マンレー, 久志本成樹, 冨永悌二

日本救急医学会雑誌　29　(10)　330-330　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
救急領域における医療安全の課題院内発症脳卒中の初療体制構築は早期診断・治療機会の向上に寄与する

大沢伸一郎, 西嶌泰生, 中川敦寛, 久志本成樹, 冨永悌二

日本救急医学会雑誌　29　(10)　397-397　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
救急集中治療室における長時間ビデオ脳波モニタリングの役割

浅黄優, 大沢伸一郎, 中川敦寛, 中里信和, 冨永悌二, 久志本成樹

日本救急医学会雑誌　29　(10)　461-461　2018/10
Publisher: (一社)日本救急医学会
ISSN： 0915-924X

eISSN： 1883-3772
過運動発作を呈した前頭葉てんかんに対する外科治療

大沢伸一郎, 岩崎真樹, 高山裕太郎, 神一敬, 中里信和, 冨永悌二

脳神経外科ジャーナル　27　(10)　764-772　2018/10
Publisher: 日本脳神経外科コングレス
ISSN： 0917-950X
2連電気刺激を用いた同一脳回皮質-皮質間誘発電位によるてんかん性異常の検出

佐藤貴文, 大沢伸一郎, 岩崎真樹, 神一敬, 三木俊, 冨永悌二, 中里信和

臨床神経生理学　46　(5)　433-433　2018/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
脳磁図の電流双極子モデルによる解析が不十分でてんかん切除術後に発作が残存した2症例における追加解析

菅野彰剛, 神一敬, 石田誠, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和

臨床神経生理学　46　(5)　437-437　2018/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
2連電気刺激を用いた同一脳回皮質-皮質間誘発電位によるてんかん性異常の検出

佐藤貴文, 大沢伸一郎, 岩崎真樹, 神一敬, 三木俊, 冨永悌二, 中里信和

臨床神経生理学　46　(5)　433-433　2018/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101
脳磁図の電流双極子モデルによる解析が不十分でてんかん切除術後に発作が残存した2症例における追加解析

菅野彰剛, 神一敬, 石田誠, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和

臨床神経生理学　46　(5)　437-437　2018/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101
てんかん切除術後に発作が残存した2症例における脳磁図の追加解析

菅野彰剛, 神一敬, 石田誠, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和

てんかん研究　36　(2)　497-497　2018/09/12
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890
選択的後大脳動脈Wada testによる海馬機能評価

大沢伸一郎, 岩崎真樹, 鈴木匡子, 新妻邦泰, 松本康史, 神一敬, 中里信和, 冨永悌二

てんかん研究　36　(2)　420-420　2018/09/12
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890
頭蓋内高周波振動(HFO)に対するプロポフォールの影響

櫻庭理絵, 大沢伸一郎, 奥村栄一, 岩崎真樹, 神一敬, 冨永悌二, 三木俊, 中里信和

てんかん研究　36　(2)　507-507　2018/09/12
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890
選択的後大脳動脈Wada testによる海馬機能評価

大沢伸一郎, 岩崎真樹, 鈴木匡子, 新妻邦泰, 松本康史, 神一敬, 中里信和, 冨永悌二

てんかん研究　36　(2)　420-420　2018/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
頭蓋内高周波振動(HFO)に対するプロポフォールの影響

櫻庭理絵, 大沢伸一郎, 奥村栄一, 岩崎真樹, 神一敬, 冨永悌二, 三木俊, 中里信和

てんかん研究　36　(2)　507-507　2018/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
脳内出血急性期の血腫吸収過程に対する桂枝茯苓丸の効果および安全性 CT画像を用いた検討

大沢伸一郎, 遠藤英徳, 川村強, 冨永悌二

Neurological Surgery　46　(9)　763-770　2018/09
Publisher: (株)医学書院
DOI： 10.11477/mf.1436203810 　

ISSN： 0301-2603

eISSN： 1882-1251

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桂枝茯苓丸(KBG)は、東洋医学的な病態(証)である「お血」に対して有効とされ、脳内出血患者には本証(赤ら顔、肥満、高血圧など)を示す症例が多い。また、KBGは皮下血腫に対する吸収促進作用や組織血流改善作用などが報告されている。今回、脳内出血患者においてKBGは血腫吸収を促進するという仮説を立て、検証を行った。対象は、当院で2013年4月〜2016年6月に入院加療された脳内出血患者53例とし、KBG投与群(21例)と非投与群に分けて血腫吸収経過を群間比較した。KBG投与の適応基準は、「お血」と関連する「赤ら顔」「がっしりとした体格」「腹診による腹部充実」とした。血腫のCT値は、来院時にはKBG投与群が63.0±6.0(HU)、非投与群が61.5±1.9で有意差なく、1週間後はそれぞれ59.0±6.0、59.0±5.0で有意差は認められなかったが、2週間後はそれぞれ44.0±7.0、48.5±4.6でKBG投与群が有意に低値であった。代表例としてKBG投与群の1例を提示した。
てんかん切除術後に発作が残存した2症例における脳磁図の追加解析

菅野彰剛, 神一敬, 石田誠, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和

てんかん研究　36　(2)　497-497　2018/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
多数のCD34陽性細胞の出現を伴う分類困難なlow-grade gliomaの3例

岡直美, 岩崎真樹, 大沢伸一郎, 金森政之, 神一敬, 宮田元, 渡辺みか, 中里信和, 上之原広司, 鈴木博義

Brain Tumor Pathology　35　(Suppl.)　163-163　2018/09
Publisher: 日本脳腫瘍病理学会
ISSN： 1433-7398
全脳梁離断術が有効であったLennox-Gastaut症候群の3例

植松貢, 阿部裕, 遠藤若葉, 植松有里佳, 矢尾板全子, 大沢伸一郎, 岩崎真樹, 呉繁夫

日本小児科学会雑誌　122　(7)　1241-1242　2018/07
Publisher: (公社)日本小児科学会
ISSN： 0001-6543
Surgical treatment of epilepsy in adults

76　(6)　987-993　2018/06
Publisher: 日本臨床社
ISSN： 0047-1852
【てんかん診療-すべての医師のための診断・治療のコツ-】てんかんの検査・診断遠隔てんかん症例検討会

柿坂庸介, 上利大, 大沢伸一郎, 神一敬, 中里信和

日本臨床　76　(6)　932-936　2018/06
Publisher: (株)日本臨床社
ISSN： 0047-1852
脳磁図の再評価とさらなる発展を目指して電流双極子によるてんかん波形の解釈てんかん診療における脳磁図の役割と電流双極子モデルの意味

柿坂庸介, 神一敬, 北澤悠, 上利大, 高山裕太郎, 大沢伸一郎, 菅野彰剛, 中里信和

日本生体磁気学会誌　31　(1)　42-43　2018/06
Publisher: 日本生体磁気学会
ISSN： 0915-0374
脳磁図の再評価とさらなる発展を目指して電流双極子によるてんかん波形の解釈てんかん診断における「電流双極子モデル」の長所と短所

中里信和, 菅野彰剛, 石田誠, 上利大, 大沢伸一郎, 柿坂庸介, 神一敬

日本生体磁気学会誌　31　(1)　40-41　2018/06
Publisher: 日本生体磁気学会
ISSN： 0915-0374
てんかん切除術後に主成分分析による脳磁図追加解析が残存発作を説明できた2例

菅野彰剛, 神一敬, 石田誠, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和

日本生体磁気学会誌　31　(1)　100-101　2018/06
Publisher: 日本生体磁気学会
ISSN： 0915-0374
Epilepsy tele-conferencing system

柿坂庸介, 上利大, 大沢伸一郎, 神一敬, 中里信和

日本臨床　76　(6)　932-936　2018/06
Publisher: (株)日本臨床社
ISSN： 0047-1852
てんかんモニタリングユニット(EMU)を支えるコメディカルの役割頭蓋内長時間脳波記録・判読における臨床検査技師の役割

櫻庭理絵, 大沢伸一郎, 神一敬

Epilepsy: てんかんの総合学術誌　12　(1)　39-41　2018/05
Publisher: (株)メディカルレビュー社
ISSN： 1882-1480
合併症 (特集早わかりポイントノートでかんたん学習くも膜下出血の看護)

大沢伸一郎

Brain nursing = ブレインナーシング　34　(2)　127-130　2018/02
Publisher: メディカ出版
ISSN： 0910-8459
くも膜下出血の合併症

大沢伸一郎

ブレインナーシング　34　31-34　2018
脳室腹腔シャント手術における腹部操作の工夫~Hasson変法を用いた開腹~

大沢伸一郎, 佐藤武揚, 西澤威人, 中川敦寛, 久志本成樹, 冨永悌二

日本整容脳神経外科学会プログラム・抄録集　11th　2018
選択的後大脳動脈Wada testによる海馬機能評価

大沢伸一郎, 新妻邦泰, 新妻邦泰, 鈴木匡子, 岩崎真樹, 佐藤健一, 遠藤英徳, 松本康史, 神一敬, 中里信和, 冨永悌二

脳血管内治療(Web)　3　(Supplement)　2018

ISSN： 2424-1709
2連電気刺激を用いた同一脳回皮質-皮質間誘発電位によるてんかん性異常の検出

佐藤貴文, 大沢伸一郎, 岩崎真樹, 岩崎真樹, 神一敬, 三木俊, 冨永悌二, 中里信和

臨床神経生理学(Web)　46　(5)　2018

ISSN： 2188-031X
衝撃波の医療応用:最近の動向もふまえて

中川敦寛, 遠藤俊毅, 遠藤英徳, 大沢伸一郎, 冨永悌二, 中西史, 横沢友樹, 山下慎一, 飯久保正弘, 佐藤由加, 佐久間篤, 八木橋真央, 近野敦, 辻田哲平, 大谷清伸

衝撃波シンポジウム講演論文集(CD-ROM)　2017　2018
松果体部胚細胞腫瘍に対する集学的治療後に発症したてんかん患者の臨床的特徴

高山裕太郎, 柿坂庸介, 大沢伸一郎, 神一敬, 菅野彰剛, 菅野彰剛, 岩崎真樹, 北澤悠, 上利大, 冨永悌二, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　41st　107　2018
半球間裂深部のてんかん性活動を脳磁図で検出した右前頭葉てんかん1例

石田誠, 菅野彰剛, 菅野彰剛, 柿坂庸介, 柿坂庸介, 神一敬, 神一敬, 岩崎真樹, 大沢伸一郎, 北澤悠, 冨永悌二, 中里信和, 中里信和

日本てんかん外科学会プログラム・抄録集　41st　95　2018
脳磁図の電流双極子モデルによる解析が不十分でてんかん切除術後に発作が残存した2症例における追加解析

菅野彰剛, 神一敬, 神一敬, 石田誠, 柿坂庸介, 柿坂庸介, 上利大, 大沢伸一郎, 岩崎真樹, 中里信和, 中里信和

臨床神経生理学(Web)　46　(5)　437(J‐STAGE)　2018

ISSN： 2188-031X
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療　2　(Suppl.)　S204-S204　2017/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 2423-9119

eISSN： 2424-1709
[Current Status of Epilepsy Surgery in Adults].

Shin-Ichiro Osawa, Masaki Iwasaki, Teiji Tominaga

Brain and nerve = Shinkei kenkyu no shinpo　69　(10)　1105-1113　2017/10
Publisher: (株)医学書院
DOI： 10.11477/mf.1416200878 　

ISSN： 1881-6096

eISSN： 1344-8129

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Epilepsy surgery is an effective way to control seizures in patients with refractory epilepsy, even in patients in whom drug therapy has not resulted in adequate seizure control. Many studies support the efficacy and safety of resective and non-resective surgeries for the treatment of refractory epilepsy in appropriately selected individuals. However, it is sometimes argued that epilepsy surgery is underutilized despite the evidence and guidelines supporting its use. Among the causes cited for underutilization of this treatment are numerous barriers to epilepsy surgery. Further strategies are needed to increase access to surgery and to improve communication about the effectiveness of this potentially life-changing procedure. In addition, epilepsy surgery is only one part of the multimodal treatment of refractory epilepsy. A comprehensive approach is required to address the medical, surgical, psychosocial, rehabilitation and moral needs of patients with epilepsy in order to improve their quality of life.
ビデオ脳波モニタリングユニット(EMU)を支えるコメディカルの役割頭蓋内長時間脳波記録・判読における臨床検査技師の役割

櫻庭理絵, 大沢伸一郎, 神一敬, 岩崎真樹, 中里信和

臨床神経生理学　45　(5)　322-322　2017/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
災害とてんかん被災者になる覚悟と救援者になる覚悟被災者の視点と支援者の視点から気仙沼市の報告

大沢伸一郎, 成田徳雄, 中里信和, 久志本成樹, 冨永悌二

てんかん研究　35　(2)　397-398　2017/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
神経救急患者のけいれん性疾患の診断予測に与える乳酸値測定の有用性連続661症例の検討から

大沢伸一郎, 藤田健亮, 神一敬, 柿坂庸介, 川村強, 今明秀, 久志本成樹, 中里信和, 冨永悌二

てんかん研究　35　(2)　508-508　2017/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
胚芽異形成性神経上皮腫瘍(DNT)と神経節膠腫における脳磁図所見の観察

高山裕太郎, 神一敬, 柿坂庸介, 菅野彰剛, 菅野彰剛, 岩崎真樹, 石田誠, 大沢伸一郎, 北澤悠, 上利大, 中里信和, 中里信和

てんかん研究　35　(2)　452-452　2017/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
エンボスフィアを用いたTAEで根治し得た海綿静脈洞部硬膜動静脈瘻の一治療例

新妻邦泰, 坂田洋之, 大沢伸一郎, 遠藤英徳, 松本康史, 冨永悌二

脳血管内治療(Web)　2　(Supplement)　2017

ISSN： 2424-1709
頭葉眼窩皮質の海綿状血管腫による難治てんかんに外科治療を行った一例

大沢伸一郎, 大沢伸一郎, 岩崎真樹, 下田由輝, 神一敬, 柿坂庸介, 岩城弘隆, 西尾慶之, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　40th　2017
慢性硬膜下血腫再発予防に対する五苓散および柴苓湯の効果比較

大沢伸一郎, 川村強

脳神経外科速報　26　(12)　2016

ISSN： 0917-1495
脳室内血腫を伴う重症くも膜下出血に対しコイル塞栓術と内視鏡下血腫吸引除去術を併用した一例

大沢伸一郎, 川村強

八戸市立市民病院医誌　34　2016

ISSN： 0389-5122
各科の特性を生かした急性期脳卒中対応により脳梗塞治療成績は改善する

大沢伸一郎, 川村強, 藤田健亮, 野田頭達也, 今明秀, 木村健介, 三浦一章

青森県自治体医学会誌　44th　2016

ISSN： 0913-4581
MRIで病巣を確認できない側頭葉てんかんの外科治療

岩崎真樹, 岩崎真樹, 神一敬, 西尾慶之, 柿坂庸介, 大沢伸一郎, 下田由輝, 中里信和, 冨永悌二

てんかん研究　34　(2)　2016

ISSN： 0912-0890
急性期脳梗塞に特化した多科横断チームによりtPA治療成績は向上する

栗原祐太朗, 大沢伸一郎, 藤田健亮, 木村健介, 木村健介, 昆祐理, 川村強, 奥島敏美, 今明秀

日本救急医学会雑誌　27　(9)　2016

ISSN： 0915-924X
院内tPA投与体制の最適化により病院前医療はtPA投与時間短縮に寄与する

藤田健亮, 大沢伸一郎, 栗原祐太朗, 木村健介, 木村健介, 川村強, 奥島敏美, 今明秀

日本救急医学会雑誌　27　(9)　2016

ISSN： 0915-924X
三叉神経根近傍の脳幹脳動静脈奇形臨床的特徴と治療成績

遠藤英徳, 佐藤健一, 大沢伸一郎, 松本康史, 藤村幹, 藤原悟, 冨永悌二

東北脳血管障害研究会学術集会記録集　37回　248-266　2015/12
Publisher: サノフィ(株)仙台オフィス
ISSN： 1880-9278
T2 Relaxometryによる海馬てんかん原性の評価

岩崎真樹, 佐藤志帆, 麦倉俊司, 大沢伸一郎, 下田由輝, 神一敬, 高橋昭喜, 中里信和, 冨永悌二

てんかん研究　33　(2)　468-468　2015/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
東日本大震災のてんかんの発症状況

柴原一陽, 柴原一陽, 大沢伸一郎, 中里信和, 冨永悌二, 成田徳雄

日本神経学会学術大会プログラム・抄録集　56th　2015
経シルビウス裂的な海馬到達法と海馬切除

岩崎真樹, 大沢伸一郎, 下田由輝, 神一敬, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　39th　2015
mobile plaqueの一例

荻田庄吾, 井上敬, 木村尚人, 大沢伸一郎, 江面正幸, 上之原広司, 冨永悌二

東北脳血管障害研究会学術集会記録集　36回　151-174　2014/12
Publisher: サノフィ(株)仙台オフィス
ISSN： 1880-9278
スパズム期に来院したくも膜下出血の治療

木村尚人, 大沢伸一郎, 江面正幸, 藤村幹, 井上敬, 上之原広司, 冨永悌二

東北脳血管障害研究会学術集会記録集　36回　232-248　2014/12
Publisher: サノフィ(株)仙台オフィス
ISSN： 1880-9278
出血発症した三叉神経根近傍の脳幹部動静脈奇形4例の治療経験

大沢伸一郎, 遠藤英徳, 佐藤健一, 松本康史, 藤村幹, 藤原悟, 冨永悌二

JNET: Journal of Neuroendovascular Therapy　8　(6)　368-368　2014/12
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
小児難治てんかんに対する一期的全脳梁離断術の発作予後および発達予後

岩崎真樹, 植松貢, 中山東城, 福與なおみ, 大沢伸一郎, 下田由輝, 神一敬, 萩野谷和裕, 中里信和, 冨永悌二

てんかん研究　32　(2)　376-376　2014/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Carotid Artery Stenting直後の遠位塞栓をPenumbra Systemにて吸引した1例-CAS後の遠位塞栓とPenumbra system-

眞野唯, 江面正幸, 坪井謙, 大沢伸一郎, 井上敬, 上之原広司

仙台医療センター医学雑誌(Web)　4　(1)　2014

ISSN： 2186-3946
小児難治てんかんに対する全脳梁離断術の発作および発達予後

岩崎真樹, 植松貢, 中山東城, 福與なおみ, 大沢伸一郎, 下田由輝, 神一敬, 萩野谷和裕, 中里信和, 冨永悌二

日本てんかん外科学会プログラム・抄録集　37th　53　2014/01
False Lateralization of Seizure Onset by Scalp EEG in Non-lesional Temporal Lobe Epilepsy : A Surgical Case Report

Iwasaki Masaki, Jin Kazutaka, Kato Kazuhiro, Osawa Shin-ichiro, Shimoda Yoshiteru, Nakasato Nobukazu, Tominaga Teiji

Japanese Journal of Neurosurgery　23　(9)　744-749　2014
Publisher: The Japanese Congress of Neurological Surgeons
DOI： 10.7887/jcns.23.744 　

ISSN： 0917-950X

eISSN： 2187-3100
頭蓋内電極による脳機能検査の新展開高域ガンマ活動に着目した認知機能マッピング

岩崎真樹, 丹治和世, 川口典彦, 大沢伸一郎, 西尾慶之, 下田由輝, 奥村栄一, 鈴木匡子, 神一敬, 中里信和, 冨永悌二

臨床神経生理学　41　(5)　324-324　2013/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
脳梁離断術中の頭皮脳波半球間コヒーレンスモニタリング

奥村栄一, 岩崎真樹, 櫻庭理絵, 板橋泉, 大沢伸一郎, 神一敬, 冨永悌二, 中里信和

臨床神経生理学　41　(5)　422-422　2013/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
記憶誘導下の連続的手指運動において、ヒト補足運動野のγ帯域の活動が上昇する

川口典彦, 大沢伸一郎, 岩崎真樹, 丹治和世, 冨永悌二, 中里信和, 青木正志, 虫明元

臨床神経生理学　41　(5)　451-451　2013/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
災害時におけるけいれん患者の増加とその対応気仙沼市における対応から(Increase in the number of seizures following the Great East-Japan Earthquake)

大沢伸一郎, 柴原一陽, 昆博之, 森田隆弘, 岩崎真樹, 中里信和, 冨永悌二, 成田徳雄

てんかん研究　31　(2)　358-358　2013/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
半球間裂アプローチによる大脳半球離断術

岩崎真樹, 大沢伸一郎, 下田由輝, 植松貢, 神一敬, 中里信和, 冨永悌二

てんかん研究　31　(2)　372-372　2013/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Continuous Time Causality analysis and its application to epileptic seizure genesis

HOSAKA Ryosuke, OHSAWA Shin-ichiro, IWASAKI Masaki, MATSUZAKA Yoshiaya, TOMITA Hiroshi, IZHIZUKA Toru, SUGANO Eriko, OKUMURA Eiichi, YAWO Hiromu, NAKASATO Nobukazu, TOMINAGA Teiji, MUSHIAKE Hajime

IEICE technical report. Nonlinear problems　113　(116)　87-91　2013/07/08
Publisher: The Institute of Electronics, Information and Communication Engineers
ISSN： 0913-5685

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The causality analysis gathers attentions again recently. The Granger causality is a well known causality measure among many caulialith measures. We applied the Granger causality to the multidimensional data and the Local Field Potential recorded during epileptic seizure genesis. Granger causality analysis of the LFPs showed a bidirectional but asymmetric increase in signal flow along the ST direction. State space presentation of the causality and coherence revealed three discrete states of the seizure-like afterdischarge phenomenon: 1) resting state; 2) afterdischarge initiation with moderate coherence and dominant septal-to-temporal causality; and 3) afterdischarge termination with increased coherence and dominant temporal-to-septal causality.
Corpus callosotomy for children with intractable generalized epilepsy : factors for long-term seizure remission

IWASAKI M, UEMATSU M, NAKAYAMA T, FUKUYO N, HAGINOYA K, JIN K, OSAWA S, NAKAZATO N, TOMINAGA T

NO TO HATTATSU　45　(3)　195-198　2013/05/01
Publisher: The Japanese Society of Child Neurology
DOI： 10.11251/ojjscn.45.195 　

ISSN： 0029-0831

eISSN： 1884-7668
Convection Enhanced Delivery(CED)を用いた新しいてんかん治療システムの開発

岩崎真樹, 大沢伸一郎, 斎藤竜太, 冨永悌二

てんかん治療研究振興財団研究年報　24　2013

ISSN： 0915-5902
Super compliant balloon‘スーパー政宗’の開発と脳動脈瘤治療での臨床応用用

井上敬, 江面正幸, 荻田庄吾, 大沢伸一郎, 上之原広司, 冨永悌二

Journal of Neuroendovascular Therapy　7　(6)　2013

ISSN： 1882-4072
てんかん発作における海馬長軸方向ネットワークの重要性:オプトジェネティクスを用いた海馬けいれんモデルでの検討

大沢伸一郎, 岩崎真樹, 保坂亮介, 松坂義哉, 富田浩史, 石塚徹, 菅野江里子, 奥村栄一, 八尾寛, 中里信和, 虫明元, 冨永悌二

日本てんかん外科学会プログラム・抄録集　36th　50　2012/12/20
東日本大震災直後のてんかん患者の実態調査

神一敬, 加藤量広, 板橋尚, 大沢伸一郎, 岩崎真樹, 曾我孝志, 中村正三, 海野美千代, 大堀守一, 冨永悌二, 中里信和

臨床神経学　52　(12)　1554-1554　2012/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
光感受性イオンチャンネルを用いた新しい海馬てんかん発作モデル(A novel hippocampal seizure model using optogenetics)

大沢伸一郎, 岩崎真樹, 保坂亮介, 松坂義哉, 富田浩史, 石塚徹, 菅野江里子, 奥村栄一, 八尾寛, 中里信和, 冨永悌二, 虫明元

てんかん研究　30　(2)　328-328　2012/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
右中心前回底部皮質形成異常に伴う難治性てんかんの一例

板橋尚, 神一敬, 中里信和, 岩崎真樹, 大沢伸一郎, 冨永悌二

てんかん研究　30　(1)　82-82　2012/06
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
標準脳へのspike mapping tool てんかんMEGの多角的分析を目指して

奥村栄一, 岩崎真樹, 菅野彰剛, 神一敬, 板橋尚, 大沢伸一郎, 加藤量広, 川島隆太, 中里信和

日本生体磁気学会誌　25　(1)　104-105　2012/06
Publisher: 日本生体磁気学会
ISSN： 0915-0374
小児てんかん外科早期手術患者の発見と利点小児難治てんかんに対する脳梁離断術長期発作寛解例の特徴

岩崎真樹, 植松貢, 佐藤優子, 中山東城, 小林朋子, 福與なおみ, 萩野谷和裕, 神一敬, 大沢伸一郎, 板橋尚, 中里信和, 冨永悌二

脳と発達　44　(Suppl.)　S129-S129　2012/05
Publisher: (一社)日本小児神経学会
ISSN： 0029-0831

eISSN： 1884-7668
コイル塞栓術後早期に再開通を来たし追加治療を要した破裂前交通動脈瘤の一例

尾股慧, 大沢伸一郎, 三野正樹, 吉田昌弘

大崎市民病院誌　16　(1)　2012

ISSN： 1881-6142
脳内血腫を伴う重症くも膜下出血に対しコイル塞栓術と内視鏡下血腫吸引除去術を併用した一例

北脇優子, 大沢伸一郎, 三野正樹, 吉田昌弘

大崎市民病院誌　16　(1)　2012

ISSN： 1881-6142
海馬硬化を伴う側頭葉てんかんに対する外科治療後の残存・再発発作の特徴

神一敬, 岩崎真樹, 大沢伸一郎, 中里信和, 冨永悌二

臨床神経学　51　(12)　1308-1308　2011/12
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
下肢の感覚運動発作を主徴とする皮質形成異常における脳磁図の有用性

板橋尚, 神一敬, 岩崎真樹, 奥村栄一, 菅野彰剛, 大沢伸一郎, 冨永悌二, 中里信和

臨床神経生理学　39　(5)　420-420　2011/10
Publisher: (一社)日本臨床神経生理学会
ISSN： 1345-7101

eISSN： 2188-031X
脳梁離断術後の発作消失

岩崎真樹, 植松貢, 佐藤優子, 中山東城, 小林朋子, 福與なおみ, 萩野谷和裕, 神一敬, 大沢伸一郎, 板橋尚, 中里信和, 冨永悌二

てんかん研究　29　(2)　353-353　2011/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
感覚運動発作を呈したbottom-of-sulcus dysplasiaの3例

板橋尚, 神一敬, 岩崎真樹, 大沢伸一郎, 冨永悌二, 中里信和

てんかん研究　29　(2)　411-411　2011/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
てんかん外科におけるMEGの役割：Multimodal fusion 画像での検討 (日本生体磁気学会誌)

岩崎真樹, 神一敬, 奥村栄一, 大沢伸一郎, 菅野彰剛, 冨永悌二, 中里信和

日本生体磁気学会誌　24　62-63　2011/06
Infratentorial oligodendroglial tumor4例の臨床病理学的検討

齋藤竜太, 隈部俊宏, 柴原一陽, 大沢伸一郎, 金森政之, 山下洋二, 園田順彦, 渡辺みか, 冨永悌二

Brain Tumor Pathology　28　(Suppl.)　090-090　2011/05
Publisher: 日本脳腫瘍病理学会
ISSN： 1433-7398

eISSN： 1861-387X
内側側頭葉てんかんに対する外科治療の長期発作予後

神一敬, 岩崎真樹, 大沢伸一郎, 中里信和, 冨永悌二

臨床神経学　51　(2)　166-166　2011/02
Publisher: (一社)日本神経学会
ISSN： 0009-918X

eISSN： 1882-0654
Convection-enhanced delivery法による新しいてんかん治療の試み

大沢伸一郎, 岩崎真樹, 中里信和, 冨永悌二

てんかん研究　28　(3)　504-504　2011/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
側頭葉てんかんに対する外科治療の長期発作予後について

岩崎真樹, 神一敬, 大沢伸一郎, 中里信和, 冨永悌二

てんかん研究　28　(3)　504-505　2011/01
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
Convection-enhanced delivery法を用いたてんかん制御の試み

大沢伸一郎, 岩崎真樹, 齋藤竜太, 杉山慎一郎, 中里信和, 冨永悌二

てんかん研究　28　(2)　230-231　2010/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
海馬硬化による側頭葉てんかんに対する外科治療の長期予後治癒例の検討

岩崎真樹, 神一敬, 大沢伸一郎, 中里信和, 冨永悌二

てんかん研究　28　(2)　290-290　2010/09
Publisher: (一社)日本てんかん学会
ISSN： 0912-0890

eISSN： 1347-5509
末梢性上小脳動脈瘤破裂の一例

高橋俊栄, 遠藤英徳, 野下展生, 大沢伸一郎, 金子宇一

JNET: Journal of Neuroendovascular Therapy　3　(4)　236-236　2009/11
Publisher: (NPO)日本脳神経血管内治療学会
ISSN： 1882-4072
診断に苦慮した後頭蓋窩anaplastic oligodendrogliomaの一例

大沢伸一郎, 園田順彦, 斎藤竜太, 隈部俊宏, 渡邊みか, 冨永悌二

Brain Tumor Pathology　26　(Suppl.)　71-71　2009/05
Publisher: 日本脳腫瘍病理学会
ISSN： 1433-7398

eISSN： 1861-387X
後下小脳動脈遠位部破裂動脈瘤の治療経験~自験例6例の検討~

遠藤英徳, 高橋俊栄, 野下展生, 大沢伸一郎, 金子宇一

日本脳神経外科学会総会抄録集(CD-ROM)　68th　2009

ISSN： 1347-9040
頚部頚動脈巨大動脈瘤のコイル塞栓後15年を経て発生したepithelioid hemangioendotheliomaの一手術例

大沢伸一郎, 斉藤敦志, 清水宏明, 渡邊みか, 冨永悌二

日本脳神経外科学会総会抄録集(CD-ROM)　68th　2009

ISSN： 1347-9040
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

Radiation Medicine　25　(Suppl.I)　29-29　2007/04
Publisher: (公社)日本医学放射線学会
ISSN： 0288-2043

eISSN： 1862-5274
高齢健常人におけるbaPWVと脳の形態変化との相関

大沢伸一郎, 瀧靖之, 後藤了以, 佐藤和則, 井上健太郎, 岡田賢, 内田信也, 志田原美保, 木之村重男, 福田寛

核医学　43　(4)　340-340　2006/11
Publisher: (一社)日本核医学会
ISSN： 0022-7854

eISSN： 2189-9932
計数過程の反応時間解析とfMRIによる大脳皮質の関連活動の解析

大沢伸一郎, 高井良樹, 細田奈生, 三輪明子, 斎藤尚宏, 虫明元, 丹治順

日本生理学雑誌　65　(12)　434-434　2003/12
Publisher: (一社)日本生理学会
ISSN： 0031-9341

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Industrial Property Rights 1

ラット脳内光誘発けいれんモデル

大沢伸一郎, 岩崎真樹, 虫明元, 八尾寛, 冨永悌二, 古澤義人, 冨田浩史

Property Type: Patent

Research Projects 13

脳深部手術のための低侵襲脳深部アクセスデバイスの開発

林俊哲, 大沢伸一郎, 中川敦寛, 佐瀬一弥, 辻田哲平, 遠藤英徳, 陳暁帥, 近野敦

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(C)

Institution: 東北大学

2024/04 - 2029/03
Novel method to identify glioblastoma invasive areas using electrophysiology.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2024/04/01 - 2027/03/31
爆風損傷の初期診療におけるトリアージ法に関する基礎研究

中川敦寛, 大谷清伸, 大沢伸一郎, 園部真也, 下田由輝, 辻田哲平, 近野敦, 佐瀬一弥

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 基盤研究(B)

Institution: 東北大学

2023/04/01 - 2026/03/31
脊髄悪性腫瘍に対する光刺激インプラントデバイスを用いた新規治療法の開発

遠藤俊毅, 新妻邦泰, 田中徹, 大沢伸一郎, 中川敦寛

Offer Organization: 日本学術振興会

System: 科学研究費助成事業

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2022/06/30 - 2025/03/31
Multidisciplinary study on the neural bases of the Japanese language based on the damaged brain - from individual differences to tailored medicine.

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2021/04/01 - 2025/03/31
The neural basis of Japanese language based on brain damaged patients - From individual differences to personalized medicine

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (B)

Institution: Tohoku University

2021/04/01 - 2025/03/31
複雑閉鎖空間中の爆風による生体内衝撃波伝播防止のための衝撃波工学・医学的検討

中川敦寛, 大沢伸一郎, 大谷清伸

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的研究(萌芽)

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2020/07/30 - 2023/03/31

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爆風脳損傷は、衝撃波を先行、かつ主成分とする爆風による脳損傷で、目に見えない外力によるため、機序、予防については解明されていない点が多い。東北大学学際衝撃波研究拠点は1970年以降世界的に拠点として衝撃波の医療応用はもちろん、さまざまな領域で衝撃波の学際研究を推進してきた。本研究の目的は、第一に閉鎖空間内で爆風損傷の先行、かつ主要成分を占める衝撃波の体内伝播動態を明らかにすること、第二に衝撃波による外傷性脳損傷を防止する技術開発に向け基礎的知見を得ることである。具体的には閉鎖空間内の反射・干渉により生体内に伝播する衝撃波を空間構造と材質で損傷閾値以下に減衰することに関して非臨床（動物実験）概念実証を確立する。本研究では、衝撃波工学の観点から模擬モデル実験と動物実験を行う。 2年目の本年は、昨年度東北大学流体科学研究所で実施してきた模擬モデル実験（単純閉鎖空間内の衝撃波伝播動態解析（高速度画像装置を用いた可視化、圧測定））および理論解析を継続するとともに、模擬モデル実験では、単純閉鎖空間内で発生する衝撃波による生体内伝播衝撃波の減弱効果を材質、壁面計状の変化による効果を可視化、圧測定および理論解析で行うとともに、複雑閉鎖空間内の衝撃波伝播動態・模擬生体内衝撃波伝播動態解析（可視化、圧測定）に着手した。次年度理論解析も推進し、衝撃波の体内伝播動態の解明と外傷性脳損傷を防止手段の構築をすすめる。
緩徐な脳圧排技術を基とした脳深部手術研究と新規脳レトラクタの開発

林俊哲, 大沢伸一郎, 佐藤洋, 中川敦寛, 荒船龍彦, 近野敦, 辻田哲平, 陳暁帥, 佐瀬一弥

Offer Organization: 日本学術振興会

System: 科学研究費助成事業基盤研究(C)

Category: 基盤研究(C)

Institution: 東北大学

2018/04/01 - 2022/03/31

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共同研究者と定期的に（概ね1／月TV会議などを利用し）会議を行い新規レトラクタの構造や材料について議論を行なっている．また，共同研究者と共に試作品を設計製作し会議にて議論を重ね，数度の改変を行い暫定的なレトラクタを作成した．さらにレトラクタが直接脳組織に接する部分については一体型の構造とせず，着脱可能なディスポーザブルなシース構造とすることを模索しており，このシースに圧モニターを装着可能とする構造を工夫中である．こちらについては新たに専門的な知識と技術を持った共同研究者を加え，東京都にて共同研究者間で議論を行い，今後の方向性や必要な準備について議論を行なった．また，次年度に予定している動物実験の実施計画書を作成し動物実験に備えた．本年の研究内容関連の報告として，第27回脳神経外科手術と機器学会のシンポジウム（2018.4月）に"小児水頭症シャント手術の技と道具"，第77回日本脳神経外科学会総会の口演（2018 10月）に”局所麻酔下内視鏡下脳内血腫摘出術の有効性の検討 preliminary study”を発表した．また，Endoscopic hematoma evacuation for intracerebral hemorrhage under local anesthesia: Factors that decide removal rate of hematoma evacuationをWorld Neurosurgeryに投稿しacceptされた．
Neural bases of individual differences of human behavior and cognition

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Institution: Tohoku University

2019/04/01 - 2021/03/31
Development of a weak shock wave pulse jet scalpel that achieves both local control of infiltrating lesions and preservation of postoperative function

Nakagawa Atsuhiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (A)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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The purpose of present study was to achieve infiltration of drug delivery to brain parenchyma through neuroendoscopic procedure by applying pulsed water jet. We have hypothesized that the penetration depth and area can be modified by applying shock wave. We have measured material property of brain and measured penetration depth and area using brain phantom and animal model. Present results showed the possibility of shock wave modified pulsed water jet can be additional treatment tool for the malignant lesion without well demarcated margin.
Muse cell therapy for the cure of epileptogenesis

Osawa Shin-ichiro

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research

Category: Grant-in-Aid for Scientific Research (C)

Institution: Tohoku University

2018/04/01 - 2021/03/31

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Muse cells are naturally pluripotent stem cells that exist in living organisms, and are a promising source of cell therapy because of their characteristics of both safety and tissue repair. There are few reports of cell therapy for epilepsy, and this time we examined the possibility of Muse cell therapy for brain damage in acute seizure model. Photic stimulation using optogenetics induces acute seizure in rodent hippocampus and then Muse cells are administered 2 days after the seizure. 3 weeks later we confirmed cells with human-derived antigens: Muse cells. In the future, behavioral experiments and biochemical evaluations are expected to prove the effect of improving epileptigenicity.
頭部外傷後精神疾患:包括的な支援体制の構築と発症要因特定のための研究基盤の形成

佐久間篤, 石垣司

Offer Organization: 日本学術振興会

System: 科学研究費助成事業挑戦的研究(萌芽)

Category: 挑戦的研究(萌芽)

Institution: 東北大学

2017/06/30 - 2021/03/31

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本年度は、東北大学病院において頭部外傷の受傷者に対する面接調査を継続した。担当者の異動によるマンパワー不足などがあり、想定通りの人数が集まらなかったが、30例程度が集積された。 これまでの研究の成果をまとめ、学会報告を行った。2019年10月、第27回精神科救急学会において、「救急医療と精神科との連携：東北大学病院精神科リエゾンチームの活動」と題して発表した。症例検討を通じて、適切な心理的支援に際して障壁となる点を明らかにした。精神科のみならず、救急科や脳神経外科など複数科、職種が受傷当初からチームとして、身体面、心理面の評価と治療に従事することが重要であること、受傷後一定期間を経て精神症状が認められる症例が多いことから、当初の受け入れ期間で1年程度の定期的なフォローアップが行われることが望ましいことなど、実践的側面につき考察し発表した。2019年11月、第32回日本総合病院精神医学会学術大会において、「軽症頭部外傷の睡眠障害：東北大学病院TBIクリニックの受傷から1年間の後方視的調査」と題して発表した。本研究では、東北大学病院TBIクリニックを受傷から12カ月間のうちに受診し、睡眠障害の評価が行われた患者を集計し関連する要因を解析した。これにより、受傷者の39％において軽度以上の睡眠障害が認められ、頭部外傷後のメンタルヘルスのスクリーニングとして、睡眠障害の評価が有効である可能性が示唆された。
Development of new therapeutic for epilepsy using convection enhanced delivery

IWASAKI Masaki

Offer Organization: Japan Society for the Promotion of Science

System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

Category: Grant-in-Aid for Young Scientists (B)

Institution: Tohoku University

2010 - 2011

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This study was designed for development of new therapeutics of intractable epilepsy. Convection-enhanced delivery (CED)is the method for delivering drugs from thin catheter tip directly into brain parenchyma with slow infusion rate. We performed CED of antiepileptic drug Levetiracetam to the hippocampus of rats with acute seizures. The Levetiracetam CED significantly reduced the occurrence and the duration of seizures. The animals showed no neurological deficits after the treatment. CED may be promising as a less invasive surgical treatment of epilepsy.

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