Details of the Researcher

PHOTO

Shota Sasaki
Section
Graduate School of Engineering
Job title
Assistant Professor
Degree

  • 博士（工学）（東北大学）

  • 修士（工学）（東北大学）

Research History 5

  • 2024/08 - Present
    エレフォーミングテクノロジー株式会社　取締役

  • 2018/04 - Present
    Tohoku University　Graduate School of Engineering　Assistant Professor

  • 2017/10 - 2018/03
    University of Minnesota　Department of Mechanical Engineering　Visiting Researcher

  • 2017/10 - 2018/03
    Japan Society for the Promotion of Science (JSPS)　Research Fellow PD

  • 2015/04 - 2017/09
    Japan Society for the Promotion of Science (JSPS)　Research Fellow DC1

Education 3

  • Tohoku University　Graduate School of Engineering　Department of Electronic Engineering

    2014/10 - 2017/09

  • Tohoku University　Graduate School of Engineering　Department of Electronic Engineering

    2013/04 - 2014/09

  • Tohoku University　School of Engineering

    2009/04 - 2013/03

Committee Memberships 2

  • 応用物理学会 プラズマエレクトロニクス分科会　幹事

    2023/04 - 2025/03

  • プラズマ・核融合学会　「プラズマ・核融合学会誌」編集委員

    2022/07 - 2024/06

Professional Memberships 3

  • Division of Plasma Electronics, THE JAPAN SOCIETY OF APPLIED PHYSICS

    2015 - Present

  • THE JAPAN SOCIETY OF APPLIED PHYSICS

    2013 - Present

  • The Japan Society of Plasma Science and Nuclear Fusion Research

    2012 - Present

Research Interests 5

  • Dinitrogen pentoxide

  • Plasma–liquid interaction

  • gene transfer

  • plasma medicine

  • atmospheric-pressure plasma

Research Areas 6

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Electrical power engineering /

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Chemical reaction and process system engineering /

  • Energy / Applied plasma science /

  • Energy / Basic plasma science /

  • Life sciences / Physiology /

  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Electronic devices and equipment /

Awards 13

  1. 20th Plasma Electronics Award

    2022/03　Division of Plasma Electronics, The Japan Society of Applied Physics

  2. 26th Encouragement Award

    2020/12　Aoba Foundation for the Promotion of Engineering

  3. The Best Presentation Award

    2020/12　The Japan Society of Plasma Science and Nuclear Fusion Research.

  4. Encouragement Award

    2020/03　Tokin Foundation for Advancement of Science and Technology

  5. RIEC Student Award

    2018/11　Research Institute of Electrical Communication, Tohoku Univ.

  6. JSAP Young Scientist Award

    2018/09　The Japan Society of Applied Physics

  7. Presidential Prize for Excellent Students

    2018/03　Tohoku University

  8. 15th Plasma Electronics Award

    2017/03　Division of Plasma Electronics, The Japan Society of Applied Physics

  9. Young Researcher Presentation Award

    2016/09　6th International Conference on Plasma Medicine (ICPM6)

  10. Gordon Research Conferences Support Award

    2016/07　Gordon Research Conference on Plasma Processing Science

  11. ICRP Best Poster Award

    2015/10　9th International Conference on Reactive Plasmas / 68th Annual Gaseous Electronics Conference / 33rd Symposium on Plasma Processing

  12. Presidential Prize for Excellent Students

    2015/03　Tohoku University

  13. 37th Lecture award in The 75th JSAP Fall Meeting

    2015/03　The Japan Society of Applied Physics

Show all ︎Show 5

Papers 29

  1. Induction of systemic resistance through calcium signaling in Arabidopsis exposed to air plasma-generated dinitrogen pentoxide International-journal Peer-reviewed

    Shota Sasaki, Hiroto Iwamoto, Keisuke Takashima, Masatsugu Toyota, Atsushi Higashitani, Toshiro Kaneko

    PLOS ONE　20　(2)　e0318757-1-16　2025/02/06

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0318757 　

    eISSN： 1932-6203

  2. Insight into the generation network of reactive oxygen species in H2O under nonthermal atmospheric-pressure plasma irradiation using a kinetic modeling approach International-journal Peer-reviewed

    Tsutomu Chida, Shota Sasaki, Kousuke Hiromori, Naomi Shibasaki-Kitakawa, Toshiro Kaneko, Atsushi Takahashi

    Chemical Engineering Journal　501　157640-1-8　2024/11/13

    Publisher: Elsevier BV

    DOI： 10.1016/j.cej.2024.157640 　

    ISSN： 1385-8947

  3. Plasma nitrogen fixation for plant cultivation with air‐derived dinitrogen pentoxide International-journal Peer-reviewed

    Shouki Takeshi, Keisuke Takashima, Shota Sasaki, Atsushi Higashitani, Toshiro Kaneko

    Plasma Processes and Polymers　21　(10)　e2400096-1-16　2024/07/11

    Publisher: Wiley

    DOI： 10.1002/ppap.202400096 　

    ISSN： 1612-8850

    eISSN： 1612-8869

    More details Close

    Abstract The development of a nonconventional nitrogen fertilizer, which can be fixed in agricultural fields using decentralized renewable energy sources, presents a feasible solution for sustainable on‐site nitrogen fixation and fertilization. This study focuses on plasma‐generated dinitrogen pentoxide (N2O5) as a prospective mediator for the on‐site nitrogen fertilization, allowing nitrogen fertilization directly into culture media. Basal dinitrogen pentoxide fertilization demonstrated almost 100% dinitrogen pentoxide dissolution efficiency as nitrate in a culture medium and nitrogen fertilization effect on plant growth without explicit symptoms of damage. Top‐dressing of dinitrogen pentoxide was also an efficient method for transferring nitrogen into the soil as nitrate, which improved plant growth and suppressed nitrogen deficiency symptoms, while overdose caused adverse effects.

  4. Integrated Transport Model for Controlled Delivery of Short-Lived Reactive Species via Plasma-Activated Liquid with Practical Applications in Plant Disease Control International-journal Invited Peer-reviewed

    Toshiro Kaneko, Keisuke Takashima, Shota Sasaki

    Plasma Chemistry and Plasma Processing　44　1165-1201　2024/06/08

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s11090-024-10461-z 　

    ISSN： 0272-4324

    eISSN： 1572-8986

    More details Close

    Abstract Gas–liquid interfacial plasmas (GLIPs), specifically atmospheric-pressure plasmas (APPs) interacting with liquids, have garnered global interest for potential applications across various fields where reactive oxygen and nitrogen species (RONS) in both the gas and liquid phases could play a key role. However, APP-induced gas- and liquid-phase chemical reactions display spatially nonuniform features and involve a number of species; thus, they are extremely complicated and have not been fully understood and controlled. Herein, our primary focus is centered on elucidating RONS transport processes in GLIPs without direct plasma-liquid contact to reduce the complexity of this mechanism. Firstly, this review delineates the simplified transport models commonly found in general GLIP systems, including: (1) the transport of remotely generated gas-phase RONS to the liquid phase; (2) liquid-phase diffusion governing dissolution into the liquid phase and volatilization loss to the gas phase; and (3) chemical reactions in the liquid phase governing the generation and loss of short-lived RONS. Second, we delve into RONS transport using our laboratory-built plasma devices, aimed at sterilizing plant pathogens, interpreting results in line with the relevant transport models to aid the comprehension of the heterogeneous transport of RONS. Third, we discussed the innovative control of the plasma reaction process in the gas phase required to selectively synthesize N2O5, which is highly reactive at the gas–liquid interface. Finally, future prospects for the efficient utilization of unique reactions at the plasma/gas–liquid interface are discussed.

  5. Increase of secondary metabolites in sweet basil (Ocimum basilicum L.) leaves by exposure to N2O5 with plasma technology International-journal Peer-reviewed

    Rie Tateishi, Natsumi Ogawa-Kishida, Nobuharu Fujii, Yuji Nagata, Yoshiyuki Ohtsubo, Shota Sasaki, Keisuke Takashima, Toshiro Kaneko, Atsushi Higashitani

    Scientific Reports　14　(1)　12759-1-11　2024/06/04

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-63508-8 　

    eISSN： 2045-2322

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    Abstract Exposure to N2O5 generated by plasma technology activates immunity in Arabidopsis through tryptophan metabolites. However, little is known about the effects of N2O5 exposure on other plant species. Sweet basil synthesizes many valuable secondary metabolites in its leaves. Therefore, metabolomic analyses were performed at three different exposure levels [9.7 (Ex1), 19.4 (Ex2) and 29.1 (Ex3) μmol] to assess the effects of N2O5 on basil leaves. As a result, cinnamaldehyde and phenolic acids increased with increasing doses. Certain flavonoids, columbianetin, and caryophyllene oxide increased with lower Ex1 exposure, cineole and methyl eugenol increased with moderate Ex2 exposure and l-glutathione GSH also increased with higher Ex3 exposure. Furthermore, gene expression analysis by quantitative RT-PCR showed that certain genes involved in the syntheses of secondary metabolites and jasmonic acid were significantly up-regulated early after N2O5 exposure. These results suggest that N2O5 exposure increases several valuable secondary metabolites in sweet basil leaves via plant defense responses in a controllable system.

  6. Utilizing plasma-generated N2O5 gas from atmospheric air as a novel gaseous nitrogen source for plants. International-journal Peer-reviewed

    Taro Yamanashi, Shouki Takeshi, Shota Sasaki, Keisuke Takashima, Toshiro Kaneko, Yasuhiro Ishimaru, Nobuyuki Uozumi

    Plant molecular biology　114　(2)　35-1-10　2024/04/08

    DOI： 10.1007/s11103-024-01438-9 　

    More details Close

    Fixing atmospheric nitrogen for use as fertilizer is a crucial process in promoting plant growth and enhancing crop yields in agricultural production. Currently, the chemical production of nitrogen fertilizer from atmospheric N2 relies on the energy-intensive Haber-Bosch process. Therefore, developing a low-cost and easily applicable method for fixing nitrogen from the air would provide a beneficial alternative. In this study, we tested the utilization of dinitrogen pentoxide (N2O5) gas, generated from oxygen and nitrogen present in ambient air with the help of a portable plasma device, as a nitrogen source for the model plant Arabidopsis thaliana. Nitrogen-deficient plants supplied with medium treated with N2O5, were able to overcome nitrogen deficiency, similar to those provided with medium containing a conventional nitrogen source. However, prolonged direct exposure of plants to N2O5 gas adversely affected their growth. Short-time exposure of plants to N2O5 gas mitigated its toxicity and was able to support growth. Moreover, when the exposure of N2O5 and the contact with plants were physically separated, plants cultured under nitrogen deficiency were able to grow. This study shows that N2O5 gas generated from atmospheric nitrogen can be used as an effective nutrient for plants, indicating its potential to serve as an alternative nitrogen fertilization method for promoting plant growth.

  7. Human coronavirus inactivation by atmospheric pressure helium plasma International-journal Peer-reviewed

    Shota Sasaki, Shion Osana, Takahiro Kubota, Mutsuo Yamaya, Hidekazu Nishimura, Ryoichi Nagatomi, Toshiro Kaneko

    Journal of Physics D: Applied Physics　55　(29)　295203-1-10　2022/05/11

    DOI： 10.1088/1361-6463/ac6a8c 　

    ISSN： 0022-3727

    eISSN： 1361-6463

  8. Experimental detection of liquid-phase OH radical decay originating from atmospheric-pressure plasma exposure International-journal Peer-reviewed

    Kazuki Takeda, Shota Sasaki, Wencheng Luo, Keisuke Takashima, Toshiro Kaneko

    Applied Physics Express　14　(5)　056001-1-5　2021/04/29

    Publisher: IOP Publishing

    DOI： 10.35848/1882-0786/abf80e 　

    ISSN： 1882-0778

    eISSN： 1882-0786

  9. Portable Plasma Device for Electric N2O5 Production from Air International-journal Peer-reviewed

    Shota Sasaki, Keisuke Takashima, Toshiro Kaneko

    Industrial & Engineering Chemistry Research　60　(1)　798-801　2020/12/22

    Publisher: American Chemical Society (ACS)

    DOI： 10.1021/acs.iecr.0c04915 　

    ISSN： 0888-5885

    eISSN： 1520-5045

  10. Continuous release of O2−/ONOO− in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation International-journal Peer-reviewed

    Shota Sasaki, Yuexing Zheng, Takayuki Mokudai, Hiroyasu Kanetaka, Masanori Tachikawa, Makoto Kanzaki, Toshiro Kaneko

    Plasma Processes and Polymers　17　(10)　e1900257-1-10　2020/05/25

    DOI： 10.1002/ppap.201900257 　

    ISSN： 1612-8850

    eISSN： 1612-8869

  11. Direct plasma stimuli including electrostimulation and OH radical induce transient increase in intracellular Ca2+ and uptake of a middle-size membrane-impermeable molecule International-journal Peer-reviewed

    Shota Sasaki, Yutaro Hokari, Akiko Kumada, Makoto Kanzaki, Toshiro Kaneko

    Plasma Processes and Polymers　15　(1)　e1700077-1-9　2017/08/25

    Publisher: Wiley-VCH Verlag

    DOI： 10.1002/ppap.201700077 　

    ISSN： 1612-8869 1612-8850

  12. Characterization of plasma-induced cell membrane permeabilization: focus on OH radical distribution International-journal Peer-reviewed

    Shota Sasaki, Ryosuke Honda, Yutaro Hokari, Keisuke Takashima, Makoto Kanzaki, Toshiro Kaneko

    Journal of Physics D: Applied Physics　49　(33)　334002-1-8　2016/07/21

    DOI： 10.1088/0022-3727/49/33/334002 　

    ISSN： 1361-6463 0022-3727

    eISSN： 1361-6463

  13. Calcium influx through TRP channels induced by short-lived reactive species in plasma-irradiated solution International-journal Peer-reviewed

    Shota Sasaki, Makoto Kanzaki, Toshiro Kaneko

    Scientific Reports　6　25728-1-11　2016/05/12

    DOI： 10.1038/srep25728 　

    ISSN： 2045-2322

  14. Highly Efficient and Minimally Invasive Transfection Using Time-Controlled Irradiation of Atmospheric-Pressure Plasma International-journal Peer-reviewed

    Shota Sasaki, Makoto Kanzaki, Toshiro Kaneko

    Applied Physics Express　7　(2)　026202-1-4　2014/01/30

    DOI： 10.7567/APEX.7.026202 　

    ISSN： 1882-0778 1882-0786

    eISSN： 1882-0786

  15. Managing the Microbiome on the Surface of Tomato Fruit by Treatment of Tomato Plants with Non-Thermal Atmospheric-Pressure Plasma During Cultivation Peer-reviewed

    Hideki Takahashi, Keisuke Takashima, Shuhei Miyashita, Shota Sasaki, Derib Alemu ABEBE, Kazuhisa Kato, Yoshinori, Toshiro Kaneko

    Horticulturae　11　(3)　276-1-20　2025/03/04

    DOI： 10.3390/horticulturae11030276 　

  16. Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides International-journal Peer-reviewed

    Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida

    Redox Biology　79　103445-1-14　2024/11/28

    Publisher: Elsevier BV

    DOI： 10.1016/j.redox.2024.103445 　

    ISSN： 2213-2317

  17. Evaluating homologous recombination activity in tissues to predict the risk of hereditary breast and ovarian cancer and olaparib sensitivity International-journal Peer-reviewed

    Tokiwa Motonari, Yuki Yoshino, Moe Haruta, Shino Endo, Shota Sasaki, Minoru Miyashita, Hiroshi Tada, Gou Watanabe, Toshiro Kaneko, Takanori Ishida, Natsuko Chiba

    Scientific Reports　14　(1)　7519-1-13　2024/04/08

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-024-57367-6 　

    eISSN： 2045-2322

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    Abstract Homologous recombination (HR) repairs DNA damage including DNA double-stranded breaks and alterations in HR-related genes results in HR deficiency. Germline alteration of HR-related genes, such as BRCA1 and BRCA2, causes hereditary breast and ovarian cancer (HBOC). Cancer cells with HR deficiency are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors and DNA-damaging agents. Thus, accurately evaluating HR activity is useful for diagnosing HBOC and predicting the therapeutic effects of anti-cancer agents. Previously, we developed an assay for site-specific HR activity (ASHRA) that can quantitatively evaluate HR activity and detect moderate HR deficiency. HR activity in cells measured by ASHRA correlates with sensitivity to the PARP inhibitor, olaparib. In this study, we applied ASHRA to lymphoblastoid cells and xenograft tumor tissues, which simulate peripheral blood lymphocytes and tumor tissues, respectively, as clinically available samples. We showed that ASHRA could be used to detect HR deficiency in lymphoblastoid cells derived from a BRCA1 pathogenic variant carrier. Furthermore, ASHRA could quantitatively measure the HR activity in xenograft tumor tissues with HR activity that was gradually suppressed by inducible BRCA1 knockdown. The HR activity of xenograft tumor tissues quantitatively correlated with the effect of olaparib. Our data suggest that ASHRA could be a useful assay for diagnosing HBOC and predicting the efficacy of PARP inhibitors.

  18. Application of nonthermal atmospheric‐pressure plasma irradiation as a new method for noncatalytic liquid‐phase selective oxidation of polyhydric alcohols International-journal Peer-reviewed

    Tsutomu Chida, Kousuke Hiromori, Naomi Shibasaki‐Kitakawa, Shota Sasaki, Toshiro Kaneko, Atsushi Takahashi

    Plasma Processes and Polymers　21　(4)　e2300163-1-8　2023/11/16

    Publisher: Wiley

    DOI： 10.1002/ppap.202300163 　

    ISSN： 1612-8850

    eISSN： 1612-8869

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    Abstract We have developed a new liquid‐phase noncatalytic selective oxidation of polyhydric alcohols such as glycerol. This method involves the use of a nonthermal atmospheric‐pressure plasma instead of precious‐metal catalysts. We found that noncatalytic selective oxidation of glycerol achieved a conversion comparable to that achieved by gold‐catalyzed oxidation, and the desired glyceric acid, which is a pharmaceutical raw material, was obtained. When the solution pH was changed from strongly alkaline to neutral, the main reaction switched from the one that occurs in the presence of gold catalysts to the one that occurs in the presence of platinum catalysts. These results suggest that the reactive oxygen species generated by nonthermal atmospheric‐pressure plasma irradiation vary depending on the solution pH.

  19. Activation of plant immunity by exposure to dinitrogen pentoxide gas generated from air using plasma technology International-journal Peer-reviewed

    Daiki Tsukidate, Keisuke Takashima, Shota Sasaki, Shuhei Miyashita, Toshiro Kaneko, Hideki Takahashi, Sugihiro Ando

    PLOS ONE　17　(6)　e0269863-1-21　2022/06/24

    Publisher: Public Library of Science (PLoS)

    DOI： 10.1371/journal.pone.0269863 　

    ISSN： 1932-6203

    eISSN： 1932-6203

  20. Liquid Spray Transport of Air Plasma Generated Reactive Species toward Plant Disease Management International-journal Peer-reviewed

    Keisuke Takashima, Yue Hu, Tsubasa Goto, Shota Sasaki, Toshiro Kaneko

    Journal of Physics D: Applied Physics　53　(35)　354004-1-10　2020/06/18

    DOI： 10.1088/1361-6463/ab87bd 　

    ISSN： 0022-3727

    eISSN： 1361-6463

  21. TRPA1 and TRPV1 channels participate in atmospheric-pressure plasma-induced [Ca2+]i response International-journal Peer-reviewed

    Masayoshi Kawase, Weijian Chen, Kota Kawaguchi, Mazvita R. Nyasha, Shota Sasaki, Hiroyasu Hatakeyama, Toshiro Kaneko, Makoto Kanzaki

    Scientific Reports　10　(1)　9687-1-11　2020/06/16

    DOI： 10.1038/s41598-020-66510-y 　

    More details Close

    Despite successful clinical application of non-equilibrium atmospheric pressure plasma (APP), the details of the molecular mechanisms underlying APP-inducible biological responses remain ill-defined. We previously reported that exposure of 3T3L1 cells to APP-irradiated buffer raised the cytoplasmic free Ca2+ ([Ca2+]i) concentration by eliciting Ca2+ influx in a manner sensitive to transient receptor potential (TRP) channel inhibitors. However, the precise identity of the APP-responsive channel molecule(s) remains unclear. In the present study, we aimed to clarify channel molecule(s) responsible for indirect APP-responsive [Ca2+]i rises. siRNA-mediated silencing experiments revealed that TRPA1 and TRPV1 serve as the major APP-responsive Ca2+ channels in 3T3L1 cells. Conversely, ectopic expression of either TRPA1 or TRPV1 in APP-unresponsive C2C12 cells actually triggered [Ca2+]i elevation in response to indirect APP exposure. Desensitization experiments using 3T3L1 cells revealed APP responsiveness to be markedly suppressed after pretreatment with allyl isothiocyanate or capsaicin, TRPA1 and TRPV1 agonists, respectively. APP exposure also desensitized the cells to these chemical agonists, indicating the existence of a bi-directional heterologous desensitization property of APP-responsive [Ca2+]i transients mediated through these TRP channels. Mutational analyses of key cysteine residues in TRPA1 (Cys421, Cys621, Cys641, and Cys665) and in TRPV1 (Cys258, Cys363, and Cys742) have suggested that multiple reactive oxygen and nitrogen species are intricately involved in activation of the channels via a broad range of modifications involving these cysteine residues. Taken together, these observations allow us to conclude that both TRPA1 and TRPV1 channels play a pivotal role in evoking indirect APP-dependent [Ca2+]i responses.

  22. Characterization of middle-molecule introduction into cells using mm-scale discharge in saline International-journal Peer-reviewed

    Ryosuke Honda, Shota Sasaki, Keisuke Takashima, Makoto Kanzaki, Takehiko Sato, Toshiro Kaneko

    Japanese Journal of Applied Physics　59　(4)　040904-1-4　2020/03/30

    DOI： 10.35848/1347-4065/ab7d7e 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  23. Quantitative evaluation of reactive oxygen and chlorine species generated by discharge in PBS International-journal Peer-reviewed

    Ryosuke Honda, Shota Sasaki, Keisuke Takashima, Takehiko Sato, Toshiro Kaneko

    Japanese Journal of Applied Physics　58　(10)　106002-1-6　2019/10/02

    DOI： 10.7567/1347-4065/ab4571 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  24. Investigation on dinitrogen pentoxide roles on air plasma effluent exposure to liquid water solution International-journal Peer-reviewed

    Yutaka Kimura, Keisuke Takashima, Shota Sasaki, Toshiro Kaneko

    Journal of Physics D: Applied Physics　52　(6)　064003-1-10　2018/12/10

    DOI： 10.1088/1361-6463/aaf15a 　

  25. Cold atmospheric plasma enhances osteoblast differentiation International-journal Peer-reviewed

    Kanako Tominami, Hiroyasu Kanetaka, Shota Sasaki, Takayuki Mokudai, Toshiro Kaneko, Yoshimi Niwano

    PLOS ONE　12　(7)　e0180507-1-15　2017/07/06

    DOI： 10.1371/journal.pone.0180507 　

    ISSN： 1932-6203

  26. Gas-liquid interfacial plasmas producing reactive species for cell membrane permeabilization International-journal Peer-reviewed

    Toshiro Kaneko, Shota Sasaki, Keisuke Takashima, Makoto Kanzaki

    Journal of Clinical Biochemistry and Nutrition　60　(1)　3-11　2016/12/17

    DOI： 10.3164/jcbn.16-73 　

    ISSN： 0912-0009 1880-5086

    eISSN： 1880-5086

  27. Roles of charged particles and reactive species on cell membrane permeabilization induced by atmospheric-pressure plasma irradiation International-journal Peer-reviewed

    Shota Sasaki, Makoto Kanzaki, Yutaro Hokari, Kanako Tominami, Takayuki Mokudai, Hiroyasu Kanetaka, Toshiro Kaneko

    Japanese Journal of Applied Physics　55　(7S2)　07LG04-1-5　2016/06/22

    DOI： 10.7567/JJAP.55.07LG04 　

    ISSN： 0021-4922

    eISSN： 1347-4065

  28. Apoptotic effects on cultured cells of atmospheric-pressure plasma produced using various gases International-journal Peer-reviewed

    Kanako Tominami, Hiroyasu Kanetaka, Tada-aki Kudo, Shota Sasaki, Toshiro Kaneko

    Japanese Journal of Applied Physics　55　(1)　01AF03-1-6　2015/12/11

    DOI： 10.7567/JJAP.55.01AF03 　

    ISSN： 0021-4922 1347-4065

    eISSN： 1347-4065

  29. Improvement of Cell Membrane Permeability Using a Cell-Solution Electrode for Generating Atmospheric-Pressure Plasma International-journal Peer-reviewed

    Toshiro Kaneko, Shota Sasaki, Yutaro Hokari, Shinichi Horiuchi, Ryosuke Honda, Makoto Kanzaki

    Biointerphases　10　(2)　029521-1-6　2015/05/21

    DOI： 10.1116/1.4921278 　

    ISSN： 1559-4106 1934-8630

    eISSN： 1559-4106

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Misc. 52

  1. On-Site Generation of N2O5 Using Atmospheric Pressure Plasma and Its Application Development

    Shota Sasaki, Toshiro Kaneko

    化学工学　89　(4)　209-212　2025/04/05

    Publisher: The Society of Chemical Engineers, Japan

  2. Control of Cell Function Using Gas-Liquid Interfacial Plasmas -Toward Minimally-Invasive and Highly-Efficient Plasma Drug Molecule Transfer- Peer-reviewed

    金子俊郎, 佐々木渉太, 本田竜介, 佐藤岳彦, 神崎展

    Vacuum and Surface Science　61　(3)　143-149　2018

    DOI： 10.1380/vss.61.143 　

    ISSN： 2433-5835

  3. 気液界面大気圧プラズマによる殺菌法と医療応用

    金子俊郎, 高島圭介, 佐々木渉太

    工業材料　65　(10)　40-44　2017

    Publisher: 日刊工業出版プロダクション ; 1955-

    ISSN： 0452-2834

  4. Nitrogen Fertilization Effect and Damage by Plasma Generated Dinitrogen Pentoxide

    武士将熙, 高島圭介, 佐々木渉太, 東谷篤志, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　70th　2023

    ISSN： 2436-7613

  5. Generation of Plasma-activated Water Mist Continuously Producing Peroxynitrous Acid (HOONO)

    佐々木渉太, 丸子高志, 西牧真木夫, 河合伸典, 北川清太郎, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　70th　2023

    ISSN： 2436-7613

  6. Experimental Detection of Short-Lived Reactive Nitrogen Species Decay Using Plasma-Exposed High-Speed Water Flow

    武田一希, 佐々木渉太, 高島圭介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　70th　2023

    ISSN： 2436-7613

  7. Activation of Plant Immune by Short Time Exposure of Plasma-generated N2O5 Gas

    岩本拡仁, 佐々木渉太, 高島圭介, 築舘大輝, 安藤杉尋, 高橋英樹, 東谷篤志, 豊田正嗣, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　70th　2023

    ISSN： 2436-7613

  8. Growth analysis and influence on tomato fruit preservation in cultivated tomato plant irradiated with atmospheric pressure plasma.

    高橋英樹, 安藤杉尋, 宮下脩平, 高島圭介, 佐々木渉太, 金子俊郎

    日本植物病理学会報　89　(1)　2023

    ISSN： 0031-9473

  9. Highly Efficient Gene Transfer in Cells by Combined Plasma and Pulsed Electric Field Treatment in Liquid

    本田竜介, 佐々木渉太, 高島圭介, 神崎展, 佐藤岳彦, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

    ISSN： 2436-7613

  10. Experimental Detection of Short-Lived Reactive Nitrogen Species Using Plasma-Exposed High-Speed Liquid Flow

    武田一希, 佐々木渉太, 高島圭介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

    ISSN： 2436-7613

  11. Activation Mechanism of Systemic Acquired Resistance in Plant Exposed to Plasma-generated N2O5 Gas

    岩本拡仁, 佐々木渉太, 高島圭介, 東谷篤志, 豊田正嗣, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

    ISSN： 2436-7613

  12. Analysis of Reaction Path in Cysteine Solution Modified by Atmospheric-pressure Plasma

    MING Shuaichen, 佐々木渉太, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　69th　2022

    ISSN： 2436-7613

  13. Activating plant immune system irradiated with novel reactive nitrogen species generated by atmospheric-pressure plasma device.

    築舘大輝, 高島圭介, 佐々木渉太, 宮下脩平, 金子俊郎, 高橋英樹, 安藤杉尋

    日本植物病理学会報　88　(1)　2022

    ISSN： 0031-9473

  14. Exploring action mechanism of plasma-synthesized dinitrogen pentoxide on living organisms using Schizosaccharomyces pombe

    岩本拡仁, 大学保一, 大学保一, 佐々木渉太, 高島圭介, 東谷篤志, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　83rd　2022

    ISSN： 2436-7613

  15. On-site Generation of Dinitrogen Pentoxide Using Atmospheric-pressure Plasma and Development of Its Applications

    佐々木渉太, 高島圭介, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　83rd　2022

    ISSN： 2436-7613

  16. Development of Air Plasma Device for On-site Production of Dinitrogen Pentoxide and Its Bio-applications

    佐々木渉太, 高島圭介, 金子俊郎

    プラズマ・核融合学会年会(Web)　39th　2022

  17. 空気を気体窒素肥料として応用する新規植物生育技術

    山梨太郎, 山梨太郎, 武士将熙, 佐々木渉太, 高島圭介, 金子俊郎, 山上睦, TANUDJAJA Ellen, 石丸泰寛, 魚住信之

    日本土壌肥料学会講演要旨集(Web)　68　2022

    ISSN： 2424-0575

  18. Precise Measurement of Plasma-Generated Liquid-Phase OH Radicals by a High Speed Species Advection System

    武田一希, 佐々木渉太, 高島圭介, 金子俊郎

    プラズマ・核融合学会年会(Web)　38th　2021

  19. Experimental Detection of Liquid-Phase OH Radical Decay Using Advection System with Atmospheric-Pressure Plasma

    武田一希, 佐々木渉太, 高島圭介, 金子俊郎

    日本物理学会講演概要集(CD-ROM)　76　(2)　2021

    ISSN： 2189-079X

  20. Study on Gene Transfer Method Using In-Liquid Plasma

    本田竜介, 佐々木渉太, 高島圭介, 神崎展, 佐藤岳彦, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　68th　2021

    ISSN： 2436-7613

  21. Roles of Dinitrogen Pentoxide in Amino-acid Modifications Using Atmospheric-pressure Air Plasma

    佐々木渉太, 高島圭介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　68th　2021

    ISSN： 2436-7613

  22. Selective Dinitrogen Pentoxide Production with Air Dielectric Barrier Discharge Plasma

    高島圭介, 佐々木渉太, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　68th　2021

    ISSN： 2436-7613

  23. Growth inhibitory effect of plasma generated dinitrogen pentoxide in Schizosaccharomyces pombe

    岩本拡仁, 大学保一, 大学保一, 佐々木渉太, 高島圭介, 東谷篤志, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　82nd　2021

    ISSN： 2436-7613

  24. プラズマ照射による新規レドックスシグナル形成とその生理学的意義の解明

    田中智弘, 佐々木渉太, 金子俊郎, 井田智章, 赤池孝章, 西田基宏, 西田基宏, 西田基宏

    日本酸化ストレス学会学術集会プログラム・抄録集　73rd　2020

  25. Utilization of In-Liquid Plasma in Highly Efficient Transfection into Cells

    本田竜介, 佐々木渉太, 高島圭介, 神崎展, 佐藤岳彦, 金子俊郎

    プラズマ・核融合学会年会(Web)　37th　2020

  26. Chemical modification of amino acids using plasma device precisely controlling reactive nitrogen species

    佐々木渉太, 高島圭介, 金子俊郎

    プラズマ・核融合学会年会(Web)　37th　2020

  27. Generation and Transport of Short-lived Reactive Species through Interface of Plasma and High-speed Liquid Flow

    金子俊郎, 武田一希, 高島圭介, 佐々木渉太

    プラズマ・核融合学会年会(Web)　37th　2020

  28. Transport Model of Short-lived Reactive Species near Interface of Plasma and High-speed Liquid Flow

    金子俊郎, LUO Wencheng, 高島圭介, 佐々木渉太

    日本物理学会講演概要集(CD-ROM)　75　(2)　2020

    ISSN： 2189-079X

  29. Analytical Evaluation of Localized Domain of Liquid Phase Reactive Species in High-speed Liquid Flow Passing through Atmospheric Pressure Plasma

    高島圭介, 佐々木渉太, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

    ISSN： 2436-7613

  30. Analysis of tyrosine derivatives generated by atmospheric-pressure plasma treatment

    柳澤真穂, 佐々木渉太, 赤澤拓斗, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

    ISSN： 2436-7613

  31. Study on Mechanism of Drug Simulated Molecule Introduction by Direct In-liquid Plasma Treatment

    本田竜介, 佐々木渉太, 高島圭介, 神崎展, 佐藤岳彦, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

    ISSN： 2436-7613

  32. Investigation of key agent and activated ion channel in plasma-induced Ca2+ response

    赤澤拓斗, 佐々木渉太, 本田竜介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

    ISSN： 2436-7613

  33. Measurement of Time-Space Distribution of OH Radical in High-speed Liquid Flow Passing through Atmospheric-pressure Plasma

    佐々木渉太, LUO Wencheng, 本田竜介, 高島圭介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　67th　2020

    ISSN： 2436-7613

  34. Surface-localized Liquid-phase OH Radical Revealed by High-speed Liquid Flow Passing through Atmospheric-pressure Plasma

    武田一希, 佐々木渉太, 本田竜介, 高島圭介, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　81st　2020

    ISSN： 2436-7613

  35. Highly Efficient Introduction of Medium Molecules and Genes Using In-Liquid Plasma

    本田竜介, 佐々木渉太, 高島圭介, 神崎展, 佐藤岳彦, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　81st　2020

    ISSN： 2436-7613

  36. Component analysis of amino acid solution treated by atmospheric-pressure helium plasma

    柳澤真穂, 佐々木渉太, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　81st　2020

    ISSN： 2436-7613

  37. Integrated Values on Liquid Phase OH Localized Domain at the Interface of High-speed Liquid Flow through Atmospheric Pressure Plasma

    高島圭介, 佐々木渉太, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　81st　2020

    ISSN： 2436-7613

  38. Novel redox signaling by plasma irradiation regulates cardiac homeostasis

    田中智弘, 田中智弘, 田中智弘, 佐々木渉太, 金子俊郎, 井田智章, 赤池孝章, 西田基宏, 西田基宏, 西田基宏

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　81st　2020

    ISSN： 2436-7613

  39. 高速液流を用いた気液界面プラズマ生成短寿命活性種濃度の時間発展計測

    LUO Wencheng, 佐々木渉太, 本田竜介, 金子俊郎

    日本物理学会講演概要集(CD-ROM)　74　(1)　2019

    ISSN： 2189-079X

  40. プラズマ処理高速液流中短寿命活性種の生成・消滅機構解明

    LUO Wencheng, 佐々木渉太, 本田竜介, 金子俊郎

    日本物理学会講演概要集(CD-ROM)　74　(2)　2019

    ISSN： 2189-079X

  41. 大気圧加湿ヘリウムプラズマ照射によって液底へ供給されるOHラジカルの径方向分布測定

    赤澤拓斗, 佐々木渉太, 本田竜介, 金子俊郎

    応用物理学会春季学術講演会講演予稿集(CD-ROM)　66th　2019

    ISSN： 2436-7613

  42. プラズマ直接照射による短寿命活性種の供給とがん細胞Ca2+応答への影響

    赤澤拓斗, 佐々木渉太, 本田竜介, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　80th　2019

    ISSN： 2436-7613

  43. プラズマ修飾反応前駆体の生成制御と生物応答

    高島圭介, 佐々木渉太, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　80th　2019

    ISSN： 2436-7613

  44. 高速液流導入大気圧プラズマを用いた液相OHラジカルの高時間分解測定

    佐々木渉太, LUO Wencheng, 本田竜介, 高島圭介, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　80th　2019

    ISSN： 2436-7613

  45. 加湿ヘリウムプラズマプルームと空気プラズマ活性ガスによって生成されるチロシン誘導体

    柳澤真穂, 佐々木渉太, 赤澤拓斗, 金子俊郎

    応用物理学会秋季学術講演会講演予稿集(CD-ROM)　80th　2019

    ISSN： 2436-7613

  46. 大気圧加湿ヘリウムプラズマによって生成される液相OHラジカルの空間分布測定

    赤澤拓斗, 本田竜介, 佐々木渉太, 金子俊郎

    プラズマ・核融合学会年会(Web)　35th　2018

  47. 気液界面プラズマ生成複合刺激による細胞膜輸送促進の機構解明

    金子俊郎, 佐々木渉太, 神崎展

    日本光医学・光生物学会　40th (Web)　2018

  48. Identification of Effective Reactive Species Generated by In-Liquid Plasma in Cell Membrane Permeability Enhancement

    保苅雄太郎, 佐々木渉太, 神崎展, 佐藤岳彦, 金子俊郎

    プラズマ・核融合学会年会(Web)　33rd　2016

  49. Measurements of Time-dependent Change in Uptake of Pharmacon-simulated Molecules into Cells Using Plasma Irradiated Solution

    ZHENG Yuexing, 佐々木渉太, 神崎展, 金子俊郎

    プラズマ・核融合学会年会(Web)　33rd　2016

  50. Optimization of Micro-Plasma in Liquid for Drug-Molecules Transfer into Adherent Cell

    保苅雄太郎, 佐々木渉太, 神埼展, 佐藤岳彦, 金子俊郎

    プラズマ・核融合学会年会(Web)　32nd　2015

  51. 遺伝子導入効率に対する大気圧プラズマ照射距離の影響

    佐々木渉太, 神崎展, 金子俊郎

    プラズマ・核融合学会年会(Web)　30th　2013

  52. 大気圧プラズマジェットによる水酸基ラジカルの生成・制御

    佐々木渉太, 高橋祥平, 石田裕康, 金子俊郎

    プラズマ・核融合学会年会(Web)　29th　2012

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Books and Other Publications 3

  1. Plasma Medical Science

    T. Kaneko, S. Sasaki, K. Takashima, M. Kanzaki, M. Tachikawa, H. Kanetaka, T. Sato, M.G. Kong

    Elsevier　2018

    ISBN: 9780128150054

  2. 高度物理刺激と生体応答 プラズマ刺激による細胞膜輸送制御

    金子俊郎, 佐々木渉太, 神崎展

    養賢堂　2017

    ISBN: 9784842505626

  3. プラズマ産業応用技術–表面処理から環境,医療,バイオ,農業 用途まで-

    金子俊郎, 佐々木渉太, 神崎展

    シ ーエムシー出版　2017

    ISBN: 9784781312569

Presentations 16

  1. Controlled generation of N2O5 and NO3 radical using air plasmas and its agricultural applications International-presentation Invited

    S. Sasaki, K. Takashima, T. Kaneko

    The 77th Gaseous Electronics Conference　2024/10/03

  2. Measurement and Numerical Calculation for Plasma-Induced Liquid Phase Chemistry Invited

    S. Sasaki, K. Takashima, T. Kaneko

    The 33rd Annual Meeting of Materials Research Society of Japan　2023/11/15

  3. Calcium Response and Large Cation Uptake Induced by Atmospheric Pressure Plasma International-presentation Invited

    S. Sasaki, R. Honda, M. Kanzaki, T. Kaneko

    Twentieth International Conference on Flow Dynamics　2023/11/06

  4. Development of Air Plasma Device for On-site Production of Dinitrogen Pentoxide and Its Bio-application Invited

    S. Sasaki, K. Takashima, T. Kaneko

    39th JSPF Annual Meeting　2022/11/24

  5. On-site Generation of Dinitrogen Pentoxide Using Atmospheric-pressure Plasma and Development of Its Applications Invited

    S. Sasaki, K. Takashima, T. Kaneko

    83rd JSAP Autumn Meeting　2022/09/21

  6. Activation of Sensory Channels in Cell Membrane Using Plasma-Generated Reactive Species International-presentation Invited

    S. Sasaki, M. Kanzaki, T. Kaneko

    Gordon Research Seminar on Plasma Processing Science　2016/07/23

  7. プラズマ活性種の計測・反応理解・制御と植物応答 Invited

    S. Sasaki, K. Takashima, T. Kaneko

    第二回プラズマ種子科学研究会　2024/01/07

  8. Development of Air Plasma Device for Selective N2O5 Supply and Future Perspectives for Its Applications Invited

    S. Sasaki, K. Takashima, H. Takahashi, T. Kaneko

    The 31st Annual Meeting of Materials Research Society of Japan　2021/12/13

  9. Selective synthesis of dinitrogen pentoxide using plasma and its biological effects Invited

    S. Sasaki, K. Takashima, H. Takahashi, T. Kaneko

    7th Global Plasma Forum　2021/08/30

  10. 大気圧空気プラズマを用いた五酸化二窒素の選択合成とその応用展望 Invited

    佐々木 渉太

    第32回 自然科学研究機構シンポジウム　2021/08/21

  11. Investigation on Interaction of N2O5-rich Plasma Effluent Gas with Tyrosine International-presentation Invited

    S. Sasaki, K. Takashima, T. Kaneko

    13th International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials 14th International Conference on Plasma-Nano Technology & Sciense　2021/03/09

  12. Roles of charged particles and reactive species on cell membrane permeabilization induced by atmospheric-pressure plasma irradiation Invited

    佐々木 渉太, 神崎 展, 保苅 雄太郎, 冨並 香菜子, 目代 貴之, 金高 弘恭, 金子 俊郎

    79th JSAP Autumn Meeting　2018/09/21

  13. Active Control of Cell Membrane Transport Using Plasma-derived Multiple Stimuli Invited

    佐々木渉太, 鄭悦星, 本田竜介, 高島圭介, 神崎展, 金子俊郎

    78th JSAP Autumn Meeting　2017/09/06

  14. プラズマによる遺伝子導入を若手が語る Invited

    佐々木 渉太, 本村 英樹, 池田 善久

    2017/05/19

  15. Effects of Plasma-produced Reactive Species on Cell Membrane Permeabilization International-presentation Invited

    S. Sasaki, Y. Hokari, M. Kanzaki, T. Kaneko

    International Workshop on Plasma Medical Science Innovation　2016/03/05

  16. "Cell Membrane Permeability of Water-soluble Macromolecules Enhanced by Atmospheric Pressure Plasma Irradiation" Invited

    佐々木 渉太, 保苅 雄太郎, 神崎 展, 金子 俊郎

    62nd JSAP Spring Meeting　2015/03/13

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Industrial Property Rights 7

  1. 植物の病害抵抗性誘導方法および植物の病害抵抗性誘導装置、ならびに、植物の病害抵抗性誘導剤

    金子 俊郎, 高島 圭介, 佐々木 渉太, 高橋 英樹, 安藤 杉尋, 東谷 篤志, 大学 保一

    特許第7660861号

    Property Type: Patent

    Holder: 国立大学法人東北大学

  2. 噴霧装置及び噴霧方法

    佐々木 渉太, 金子 俊郎, 北川 清太郎, 丸子 高志

    特許第7361324号

    Property Type: Patent

    Holder: ナルックス株式会社，国立大学法人東北大学

  3. 遺伝子または薬剤導入方法、および、遺伝子または薬剤導入剤

    金子 俊郎, 佐々木 渉太

    特許第6950938号

    Property Type: Patent

    Holder: 国立大学法人東北大学

  4. 遺伝子導入装置及び遺伝子導入方法

    金子 俊郎, 佐々木 渉太, 神崎 展, 加藤 俊顕

    特許第6432945号

    Property Type: Patent

    Holder: 国立大学法人東北大学

  5. 噴霧方法

    佐々木 渉太, 金子 俊郎, 北川 清太郎, 河合 伸典, 丸子 高志, 西牧 真木夫

    Property Type: Patent

  6. 体内用プラズマ発生装置，遺伝子導入装置，薬剤導入装置および内視鏡

    金子 俊郎, 佐々木 渉太, 佐藤 岳彦

    Property Type: Patent

  7. DINITROGEN PENTOXIDE GENERATING DEVICE AND METHOD FOR GENERATING DINTROGEN PENTOXIDE

    Toshiro KANEKO, Keisuke TAKASHIMA, Shota SASAKI

    Property Type: Patent

    Holder: TOHOKU UNIVERSITY

Show all Show first 5

Research Projects 16

  1. Innovative technology for controlled synthesis of reactive species by elucidating spatio-temporal dynamics of plasma gas-liquid interfacial reactions Competitive

    Toshiro Kaneko, Keisuke Takashima, Shota Sasaki, Masaya Shigata, Makoto Sugimoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (S)

    Institution: Tohoku University

    2022/04/27 - 2027/03/31

  2. 低次元界面液体におけるプラズマ電荷・活性種の時空間ダイナミクスの体系的解明 Competitive

    Toshiro Kaneko, Keisuke Takashima, Shota Sasaki, Masaya Shigata

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2022/04/01 - 2026/03/31

  3. Development of on-site synthesis of functional reactive species composed of hydrogen Competitive

    Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04 - 2026/03

  4. Research and development on inactivation of airborne substances such as virus particles using plasma micro mist Competitive

    Toshiro Kaneko, Shota Sasaki

    Offer Organization: Japan Science and Technology Agency

    System: A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R&D)

    Institution: Tohoku University

    2021/10 - 2024/03

  5. Novel Cell Function Control Using Plasma Selective Transport and Radical Reaction Delay under Tesla-class Strong Magnetic Field Competitive

    Toshiro Kaneko, Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grant-in-Aid for Challenging Research (Exploratory)

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2021/07 - 2024/03

  6. プラズマ照射システイン溶液における過硫化物の同定とその生成機構解明 Competitive

    Shota Sasaki, Motohiro Nishida, Tomoyuki Nishimura, Kakeru Shimoda

    Offer Organization: National Institutes of Natural Sciences

    System: 2022 Plasma-Bio Consortium Project

    Institution: Tohoku University

    2022/09 - 2023/03

  7. Investigation on chemical reactions induced by discharge with historical atmospheric composition and application for controlled synthesis of bioactive molecules Competitive

    Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grant-in-Aid for Young Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2021/04 - 2023/03

  8. 活性種精密制御プラズマ源を用いた活性種―生体分子ネットワークの解析と生理活性分子の探索 Competitive

    Shota Sasaki, Toshiro Kaneko, Keisuke Takashima, Motohiro Nishida, Tomohiro Tanaka

    Offer Organization: National Institutes of Natural Sciences

    System: 2021 Plasma-Bio Consortium Project

    Institution: Tohoku University

    2021/06 - 2022/03

  9. 遍在型プラズマ装置を活用したカゼコロナウイルスの高効率不活化技術の確立 Competitive

    Shota Sasaki, Shion Osana

    Offer Organization: Center of Innovation (COI) Tohoku Site

    System: Site young researcher fund

    Institution: Tohoku University

    2021/05 - 2022/03

  10. 遍在型五酸化二窒素供給源による飛沫中ウイルスの広範囲・高効率不活化の実証 Competitive

    Toshiro Kaneko, Shota Sasaki

    Offer Organization: Japan Science and Technology Agency

    System: A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R&D)

    Category: Tryout (2021)

    Institution: Tohoku University

    2021/03 - 2022/03

  11. プラズマ照射に起因する細胞内・細胞外活性硫黄種動態とその制御機構解明 Competitive

    Shota Sasaki, Toshiro Kaneko, Keisuke Takashima, Motohiro Nishida, Tomohiro Tanaka

    Offer Organization: National Institutes of Natural Sciences

    System: 2020 Plasma-Bio Consortium Project

    Institution: Tohoku University

    2020/06 - 2021/03

  12. プラズマ合成機能性窒素を用いたカゼコロナウイルス感染対策に 関する基礎研究 Competitive

    Shota Sasaki, Shion Osana

    Offer Organization: Center of Innovation (COI) Tohoku Site

    System: Site young researcher fund

    Institution: Tohoku University

    2020/05 - 2021/03

  13. Screening of biologically-sensitive reactive species and membrane receptors using discharge under the Proterozoic environment Competitive

    Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grant-in-Aid for Young Scientists

    Category: Grant-in-Aid for Early-Career Scientists

    Institution: Tohoku University

    2019/04 - 2021/03

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    This study aims to identify atmospherically-derived reactive species which effectively induce cellular responses and clarify the sensing mechanism. The highlight of the results/conclusions is that continuously-generated liquid-phase O2-/ONOO- over a few minutes, which is triggered by irradiation of a nonequilibrium atmospheric pressure plasma, activated TRPA1/TRPV1 channels via key cysteine residues roles.

  14. Challenge to simultaneous measuring of infinitesimal heterogeneous plasma stimuli using ultrasensitive cell-based sensor array Competitive

    KANEKO Toshiro, SASAKI shota

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    We have challenged to create “ultrasensitive cell-based sensor array” which can detect the temporal-spatial distribution of infinitesimal heterogeneous stimuli generated by the atmospheric pressure non-equilibrium plasmas. We measured the 2-dimensional distribution of oxidation stimulus (reactive species), electric stimulus (charged particles), pressure stimulus (shock wave) which were generated in the solution irradiated with atmospheric pressure plasma jet or in-liquid micro plasma. Furthermore, we arrayed the cells which have overexpressing channels responding with each stimulus, and measured the 2-dimentional distribution of fluorescence intensity proportional to the concentration of calcium ion or gene-simulated fluorescent molecule in the cells. As a result, we have demonstrated that the cells can act as the sensor arrays for oxidation stimulus, electric stimulus, and pressure stimulus.

  15. Time and spatially resolved measurement of reactive species distribution toward development of plasma-induced drug delivery system Competitive

    Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Overseas Challenge Program for Young Researchers

    Institution: Tohoku University

    2017/10 - 2018/03

  16. 帯電液滴重畳反応性プラズマジェットによる高分子薬剤の高効率細胞内導入 Competitive

    Shota Sasaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grant-in-Aid for JSPS Fellows

    Institution: Tohoku University

    2015/04 - 2018/03

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