Details of the Researcher

PHOTO

Yuka Sakuma
Section
Graduate School of Science
Job title
Associate Professor
Degree

  • 博士（理学）

Committee Memberships 4

  • 日本物理学会領域１２運営委員　国内外学会役員等

    2025/09 - Present

  • 日本生物物理学会東北支部・会計　国内外学会役員等

    2025/05 - Present

  • 理学研究科男女共同参画推進委員　学内委員

    2025/04 - Present

  • 日本物理学会東北支部・出前授業　国内外学会役員等

    2022/04 - Present

Professional Memberships 3

  • Biophysical Society

  • 日本中性子科学会

  • 日本物理学会

Research Interests 5

  • C. elegans

  • biophysics

  • membrane viscosity

  • lipid vesicle

  • ソフトマター物理学

Research Areas 1

  • Natural sciences / Bio-, chemical, and soft-matter physics /

Awards 1

  1. 東北大理学部物理系同窓会「泉萩会」第６回泉萩会奨励賞受賞

    2014/10/25　東北大理学部物理系同窓会「泉萩会」

Papers 32

  1. Long-range viscosity of the plasma membrane of a living cell measured by a shear-driven flow method Peer-reviewed

    Yuka Sakuma, Kazunori Yamamoto, Saya Ichihara, Toshihiro Kawakatsu, Kenya Haga, Masayuki Imai, Akatsuki Kimura

    Biophysical Journal　124　(19)　3304-3318　2025/09

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2025.09.005 　

    ISSN： 0006-3495

  2. Temperature dependence of membrane viscosity of ternary lipid GUV with Lo domains Peer-reviewed

    Julia Tanaka, Kenya Haga, Naohito Urakami, Masayuki Imai, Yuka Sakuma

    Biophysical Journal　124　(5)　818-828　2025/03

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2025.01.024 　

    ISSN： 0006-3495

  3. Translocation of a daughter vesicle in a model system of self-reproducing vesicles Peer-reviewed

    Manit Klawtanong, Yuka Sakuma, Masayuki Imai, Toshihiro Kawakatsu, Petch Khunpetch

    Physics of Fluids　36　(2)　027112-1-9　2024/02/01

    Publisher: AIP Publishing

    DOI： 10.1063/5.0186977 　

    ISSN： 1070-6631

    eISSN： 1089-7666

    More details Close

    Translocation of a daughter vesicle from a mother vesicle through a pore is experimentally studied by many groups using a model system of self-reproducing vesicles. However, the theoretical formulation of the problem is not fully understood. In the present study, we present a theoretical formulation of the process based on our previous work [P. Khunpetch et al., Phys. Fluids 33, 077103 (2021)]. In our previous work, we considered the daughter vesicle as a rigid body. In the present work, however, we allow the daughter vesicle to deform during the expulsion process. We thus derive the free energy constituting of the elastic moduli of both the mother and daughter vesicles, and of pressure-driven contribution. The minimum energy path of the translocation is searched by using the string method. With use of experimentally reasonable values of the elastic moduli, our improved model successfully reproduced the progress of the birthing process where there is no free energy barrier between the initial and the final states. The equations of motion of the daughter vesicle have been derived within the framework of the Onsager principle. We found that the translocation time of the daughter vesicle can be reduced when the pressure inside the mother vesicle increases, or the initial size of the daughter vesicle decreases.

  4. Effects of grafted polymers on the lipid membrane fluidity Peer-reviewed

    Yuka Sakuma, Nana Kayamori, Julia Tanaka, Kenya Haga, Masayuki Imai, Toshihiro Kawakatsu

    Biophysical Journal　123　(4)　489-501　2024/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2024.01.014 　

    ISSN： 0006-3495

  5. Morphology of vesicle triplets: shape transformation at weak and strong adhesion limits Peer-reviewed

    Toshikaze Chiba, Yuka Sakuma, Masayuki Imai, Primož Ziherl

    Soft Matter　19　(23)　4286-4296　2023/05

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d3sm00308f 　

    ISSN： 1744-683X

    eISSN： 1744-6848

    More details Close

    We investigate the morphologies of adhering vesicle triplets (triangular and linear topologies) in strong and weak adhesion regimes.

  6. Synthesising a minimal cell with artificial metabolic pathways Peer-reviewed

    Minoru Kurisu, Ryosuke Katayama, Yuka Sakuma, Toshihiro Kawakatsu, Peter Walde, Masayuki Imai

    Communications Chemistry　6　(1)　56-1-14　2023/03/28

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42004-023-00856-y 　

    eISSN： 2399-3669

    More details Close

    Abstract A “synthetic minimal cell” is considered here as a cell-like artificial vesicle reproduction system in which a chemical and physico-chemical transformation network is regulated by information polymers. Here we synthesise such a minimal cell consisting of three units: energy production, information polymer synthesis, and vesicle reproduction. Supplied ingredients are converted to energy currencies which trigger the synthesis of an information polymer, where the vesicle membrane plays the role of a template. The information polymer promotes membrane growth. By tuning the membrane composition and permeability to osmolytes, the growing vesicles show recursive reproduction over several generations. Our “synthetic minimal cell” greatly simplifies the scheme of contemporary living cells while keeping their essence. The chemical pathways and the vesicle reproduction pathways are well described by kinetic equations and by applying the membrane elasticity model, respectively. This study provides new insights to better understand the differences and similarities between non-living forms of matter and life.

  7. From Vesicles toward Protocells and Minimal Cells

    Masayuki Imai, Yuka Sakuma, Minoru Kurisu, Peter Walde

    Soft Matter　2022

    Publisher: Royal Society of Chemistry (RSC)

    DOI： 10.1039/d1sm01695d 　

    ISSN： 1744-683X

    eISSN： 1744-6848

    More details Close

    In contrast to ordinary condensed matter systems, “living systems” are unique. They are based on molecular compartments that reproduce themselves through (i) an uptake of ingredients and energy from the...

  8. Birthing of a daughter vesicle in a model system for self-reproduction vesicles Peer-reviewed

    Petch Khunpetch, Yuka Sakuma, Masayuki Imai, Toshihiro Kawakatsu

    Physics of Fluids　33　(7)　077103-077103　2021/07

    Publisher: AIP Publishing

    DOI： 10.1063/5.0052248 　

    ISSN： 1070-6631

    eISSN： 1089-7666

  9. Vesicle deformation and division induced by flip-flop of lipid molecules Peer-reviewed

    Naohito Urakami, Yuka Sakuma, Toshikaze Chiba, Masayuki Imai

    Soft Matter　17　(37)　8434-8445　2021

    DOI： 10.1039/d1sm00847a 　

    ISSN： 1744-683X

    eISSN： 1744-6848

  10. Viscosity of multicomponent liposome Invited Peer-reviewed

    Yuka Sakuma

    MEMBRANE　46　(2)　58-64　2021

    Publisher: The Membrane Society of Japan

    DOI： 10.5360/membrane.46.58 　

    ISSN： 0385-1036

    eISSN： 1884-6440

  11. Morphologies of Vesicle Doublets: Competition among Bending Elasticity, Surface Tension, and Adhesion Peer-reviewed

    Kei Murakami, Ryuta Ebihara, Takuma Kono, Toshikaze Chiba, Yuka Sakuma, Primož Ziherl, Masayuki Imai

    Biophysical Journal　119　(9)　1735-1748　2020/11

    Publisher: Elsevier BV

    DOI： 10.1016/j.bpj.2020.09.030 　

    ISSN： 0006-3495

  12. Viscosity Landscape of Phase-Separated Lipid Membrane Estimated from Fluid Velocity Field Peer-reviewed

    Yuka Sakuma, Toshihiro Kawakatsu, Takashi Taniguchi, Masayuki Imai

    Biophysical Journal　2020/04

  13. Reproduction of vesicles coupled with a vesicle surface-confined enzymatic polymerisation Peer-reviewed

    Minoru Kurisu, Harutaka Aoki, Takehiro Jimbo, Yuka Sakuma, Masayuki Imai, Sandra Serrano-Luginbühl, Peter Walde

    communications chemistry　2　2019/11

    DOI： 10.1038/s42004-019-0218-0 　

  14. Migration of Deformable Vesicles Induced by Ionic Stimuli Peer-reviewed

    Atsuji Kodama, Mattia Morandi, Ryuta Ebihara, Takehiro Jimbo, Masayuki Toyoda, Yuka Sakuma, Masayuki Imai, Nicolas Puff, Miglena I. Angelova

    Langmuir　34　11484-11494　2018/08

    DOI： 10.1021/acs.langmuir.8b02105 　

  15. Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures Peer-reviewed

    Naohito Urakami, Takehiro Jimbo, Yuka Sakuma, Masayuki Imai

    Soft Matter　14　(16)　3018-3027　2018

    Publisher: Royal Society of Chemistry

    DOI： 10.1039/c7sm02188g 　

    ISSN： 1744-6848 1744-683X

  16. Migration of Phospholipid Vesicles Can Be Selectively Driven by Concentration Gradients of Metal Chloride Solutions Peer-reviewed

    Atsuji Kodama, Yuka Sakuma, Masayuki Imai, Toshihiro Kawakatsu, Nicolas Puff, Miglena I. Angelova

    LANGMUIR　33　(40)　10698-10706　2017/10

    DOI： 10.1021/acs.langmuir.7b02617 　

    ISSN： 0743-7463

  17. Role of Inverse-Cone-Shape Lipids in Temperature-Controlled Self-Reproduction of Binary Vesicles Peer-reviewed

    Takehiro Jimbo, Yuka Sakuma, Naohito Urakami, Primoz Ziherl, Masayuki Imai

    BIOPHYSICAL JOURNAL　110　(7)　1551-1562　2016/04

    DOI： 10.1016/j.bpj.2016.02.028 　

    ISSN： 0006-3495

    eISSN： 1542-0086

  18. 22aBW-8 Pore Formation on the Vesicle Induced by Chemical Stimuli

    Sakuma Y., Kodama A., Imai M.

    Meeting Abstracts of the Physical Society of Japan　71　3268-3268　2016

    Publisher: The Physical Society of Japan (JPS)

    DOI： 10.11316/jpsgaiyo.71.1.0_3268 　

    ISSN： 2189-079X

  19. Migration of phospholipid vesicles in response to OH- stimuli Peer-reviewed

    Atsuji Kodama, Yuka Sakuma, Masayuki Imai, Yutaka Oya, Toshihiro Kawakatsu, Nicolas Puff, Miglena I. Angelova

    SOFT MATTER　12　(11)　2877-2886　2016

    DOI： 10.1039/c5sm02220g 　

    ISSN： 1744-683X

    eISSN： 1744-6848

  20. 18pCT-6 Migration of phospholipid vesicles in response to chemical stimuli

    Kodama A., Sakuma Y., Imai M., Oya Y., Kawakatsu T., Puff Nicolas, Angelova Miglena I.

    Meeting Abstracts of the Physical Society of Japan　70　2995-2995　2015

    Publisher: The Physical Society of Japan (JPS)

    DOI： 10.11316/jpsgaiyo.70.2.0_2995 　

    ISSN： 2189-079X

  21. 21pAQ-3 Response of Fatty Acid Vesicles to pH Stimuli

    Ikari K., Sakuma Y., Imai M., Monnard P.-A., Rasmussen S.

    Meeting Abstracts of the Physical Society of Japan　70　3264-3264　2015

    Publisher: The Physical Society of Japan (JPS)

    DOI： 10.11316/jpsgaiyo.70.1.0_3264 　

    ISSN： 2189-079X

  22. Dynamics of fatty acid vesicles in response to pH stimuli Peer-reviewed

    Keita Ikari, Yuka Sakuma, Takehiro Jimbo, Atsuji Kodama, Masayuki Imai, Pierre-Alain Monnard, Steen Rasmussen

    SOFT MATTER　11　(31)　6327-6334　2015

    DOI： 10.1039/c5sm01248a 　

    ISSN： 1744-683X

    eISSN： 1744-6848

  23. Tubular Membrane Formation of Binary Giant Unilamellar Vesicles Composed of Cylinder and Inverse-Cone-Shaped Lipids Peer-reviewed

    Yuka Sakuma, Takashi Taniguchi, Toshihiro Kawakatsu, Masayuki Imai

    BIOPHYSICAL JOURNAL　105　(9)　2074-2081　2013/11

    DOI： 10.1016/j.bpj.2013.09.021 　

    ISSN： 0006-3495

    eISSN： 1542-0086

  24. Slow Dynamics of Surfactant Micelles in Fluid and Crystal Phases Peer-reviewed

    M. Imai, M. Kurimoto, F. Matsuura, Y. Sakuma, T. Kawakatsu

    4TH INTERNATIONAL SYMPOSIUM ON SLOW DYNAMICS IN COMPLEX SYSTEMS: KEEP GOING TOHOKU　1518　758-765　2013

    DOI： 10.1063/1.4794675 　

    ISSN： 0094-243X

  25. Lipid membrane deformation in response to a local pH modification: theory and experiments Peer-reviewed

    Anne-Florence Bitbol, Nicolas Puff, Yuka Sakuma, Masayuki Imai, Jean-Baptiste Fournier, Miglena I. Angelova

    SOFT MATTER　8　(22)　6073-6082　2012

    DOI： 10.1039/c2sm25519g 　

    ISSN： 1744-683X

  26. Diffusion of surfactant micelles in fluid and crystal phases Peer-reviewed

    M. Imai, M. Kurimoto, F. Matsuura, Y. Sakuma, T. Kawakatsu

    SOFT MATTER　8　(38)　9892-9905　2012

    DOI： 10.1039/c2sm07122c 　

    ISSN： 1744-683X

    eISSN： 1744-6848

  27. Model System of Self-Reproducing Vesicles Peer-reviewed

    Yuka Sakuma, Masayuki Imai

    PHYSICAL REVIEW LETTERS　107　(19)　198101-1-198101-5　2011/10

    DOI： 10.1103/PhysRevLett.107.198101 　

    ISSN： 0031-9007

  28. Asymmetric distribution of cone-shaped lipids in a highly curved bilayer revealed by a small angle neutron scattering technique Peer-reviewed

    Y. Sakuma, N. Urakami, T. Taniguchi, M. Imai

    JOURNAL OF PHYSICS-CONDENSED MATTER　23　(28)　284104-1-284104-6　2011/07

    DOI： 10.1088/0953-8984/23/28/284104 　

    ISSN： 0953-8984

  29. Pore Formation in a Binary Giant Vesicle Induced by Cone-Shaped Lipids Peer-reviewed

    Yuka Sakuma, Takashi Taniguchi, Masayuki Imai

    BIOPHYSICAL JOURNAL　99　(2)　472-479　2010/07

    DOI： 10.1016/j.bpj.2010.03.064 　

    ISSN： 0006-3495

  30. Diffusion of domains on nanometer sized vesicle Peer-reviewed

    Y. Sakuma, N. Urakami, Y. Ogata, M. Nagao, S. Komura, T. Kawakatsu, M. Imai

    INTERNATIONAL CONFERENCE ON NEUTRON SCATTERING 2009　251　012036-1-012036-4　2010

    DOI： 10.1088/1742-6596/251/1/012036 　

    ISSN： 1742-6588

  31. Adhesion of binary giant vesicles containing negative spontaneous curvature lipids induced by phase separation Peer-reviewed

    Y. Sakuma, M. Imai, M. Yanagisawa, S. Komura

    EUROPEAN PHYSICAL JOURNAL E　25　(4)　403-413　2008/04

    DOI： 10.1140/epje/i2007-10307-0 　

    ISSN： 1292-8941

  32. Dynamics of nano-meter-sized domains on a vesicle Peer-reviewed

    Y. Sakuma, N. Urakami, Y. Ogata, M. Nagao, S. Komura, M. Imai

    COMPLEX SYSTEMS-BOOK 1　982　717-+　2008

    DOI： 10.1063/1.2897885 　

    ISSN： 0094-243X

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Misc. 28

  1. 膜グラフト高分子のコンフォメーション転移による拡散係数への影響

    高田翔太郎, 村島隆浩, 浦上直人, 川勝年洋, 今井正幸, 佐久間由香

    分子シミュレーション討論会講演要旨集　38th　2024

  2. pH sensing by lipids in membranes: The fundamentals of pH-driven migration, polarization and deformations of lipid bilayer assemblies Invited Peer-reviewed

    Miglena I. Angelova, Anne-Florence Bitbol, Michel Seigneuret, Galya Staneva, Atsuji Kodama, Yuka Sakuma, Toshihiro Kawakatsu, Masayuki Imai, Nicolas Puff

    Biochimica et Biophysica Acta - Biomembranes　2018

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.bbamem.2018.02.026 　

    ISSN： 1879-2642 0005-2736

  3. From vesicles to protocells: The roles of amphiphilic molecules

    Yuka Sakuma, Masayuki Imai

    Life　5　(1)　651-675　2015/03/02

    Publisher: MDPI AG

    DOI： 10.3390/life5010651 　

    ISSN： 2075-1729

  4. 30pAC-8 Three-Dimensional Analysis of Self-reproducing Vesicles

    Jimbo T., Sakuma Y., Urakami N., Ziherl Primoz, Imai M.

    Meeting abstracts of the Physical Society of Japan　69　(1)　440-440　2014/03/05

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  5. ベシクルからプロトセルへのアプローチ Invited Peer-reviewed

    佐久間 由香, 今井 正幸

    膜学会誌　39　316-321　2014

    DOI： 10.5360/membrane.39. 　

  6. Tubular formation of lipid vesicles induced by coupling of spontaneous curvature and phase separation

    Sakuma Yuka, Taniguchi Takashi, Kawakatsu Toshihiro, Imai Masayuki

    Meeting abstracts of the Physical Society of Japan　68　(2)　308-308　2013/08/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  7. Drastic deformation of phospholipid vesicles coupled with chemophoresis

    Kodama Atsuji, Sakuma Yuka, Imai Masayuki, Kawakatsu Toshihiro

    Meeting abstracts of the Physical Society of Japan　68　(2)　308-308　2013/08/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  8. Three-Dimensional Analysis of Self-reproducing Vesicles

    Jimbo T., Sakuma Y., Urakami N., Ziherl P., Imai M.

    Meeting abstracts of the Physical Society of Japan　68　(2)　307-307　2013/08/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  9. From vesicle to protocell

    Yuka Sakuma, Masayuki Imai

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　245　2013/04

    ISSN： 0065-7727

  10. 28pXC-4 Chemophoresis of neutral phospholipid vesicles

    Kodama Atsuji, Sakuma Yuka, Imai Masayuki, Kawakatsu Toshihiro

    Meeting abstracts of the Physical Society of Japan　68　(1)　440-440　2013/03/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  11. 28pXC-7 Lipid membrane deformation triggered by chemical stimulation

    Sakuma Yuka, Bitbol Anne-Florence, Puff Nicolas, Imai Masayuki, Fournier Jean-Baptiste, Angelova Miglena I.

    Meeting abstracts of the Physical Society of Japan　68　(1)　440-440　2013/03/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  12. 28pXC-3 Slow Dynamics of Soft Spherical Particles

    Imai Masayuki, Sakuma Yuka, Kawakatsu Toshihiro

    Meeting abstracts of the Physical Society of Japan　68　(1)　439-439　2013/03/26

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  13. 中性子小角散乱で見たLipid Sorting

    佐久間由香, 今井正幸

    波紋（日本中性子科学会）　23　(1)　56-61　2013/02

    Publisher: 「波紋」編集委員会

    ISSN： 1349-046X

  14. Model of Self Reproducing Vesicles

    Yuka Sakuma, Masayuki Imai

    BIOPHYSICAL JOURNAL　102　(3)　33A-33A　2012/01

    ISSN： 0006-3495

  15. Lipid Membrane Deformation in Response to a Local pH Modification

    Anne-Florence Bitbol, Nicolas Puff, Yuka Sakuma, Masayuki Imai, Jean-Baptiste Fournier, Miglena I. Angelova

    BIOPHYSICAL JOURNAL　102　(3)　33A-33A　2012/01

    ISSN： 0006-3495

  16. 22pJF-6 Asymmetric Distribution of Lipids Induced by Membrane Curvature

    Sakuma Yuka, Imai Masayuki

    Meeting abstracts of the Physical Society of Japan　66　(2)　320-320　2011/08/24

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  17. 25pTB-12 Birthing Dynamics of Vesicles

    Sakuma Yuka, Imai Masayuki

    Meeting abstracts of the Physical Society of Japan　65　(2)　336-336　2010/08/18

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  18. 23aPS-102 Deformation of vesicles controlled by spontaneous curvatures of lipids

    Sakuma Yuka, Taniguchi Takashi, Kawakatsu Toshihiro, Imai Masayuki

    Meeting abstracts of the Physical Society of Japan　65　(1)　402-402　2010/03/01

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  19. Shape deformations of multicomponent vesicles

    Masayuki Imai, Yuka Sakuma

    Advances in Planar Lipid Bilayers and Liposomes　12　(C)　41-78　2010

    DOI： 10.1016/B978-0-12-381266-7.00003-1 　

    ISSN： 1554-4516

  20. Diffusion of Nano-Meter-Sized Domains on A Vesicle

    Yuka Sakuma, Masayuki Imai, Naohito Urakami, Michihiro Nagao, Shigeyuki Komura, Toshihiro Kawakatsu

    BIOPHYSICAL JOURNAL　98　(3)　220A-220A　2010/01

    ISSN： 0006-3495

  21. Deformation of Vesicles Controlled by Local Spontaneous Curvatures of Membrane

    Yuka Sakuma, Masayuki Imai, Takashi Taniguchi, Toshihiro Kawakatsu

    BIOPHYSICAL JOURNAL　98　(3)　665A-666A　2010/01

    ISSN： 0006-3495

  22. ベシクル膜面上でのナノドメインダイナミクス

    佐久間由香, 浦上直人, 緒方祐介, 長尾道弘, 好村滋行, 川勝年洋, 今井正幸

    日本物理学会講演概要集　64　(2)　248-248　2009/08/18

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  23. 30aPS-114 Deformation of vesicles controlled by spontaneous curvatures of lipids

    Sakuma Yuka, Taniguchi Takashi, Kawakatsu Toshihiro, Imai Masayuki

    Meeting abstracts of the Physical Society of Japan　64　(1)　390-390　2009/03/03

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  24. ナノスケールにおける脂質ドメインの拡散

    佐久間由香, 今井正幸, 浦上直人, 長尾道弘, 好村滋行, 川勝年洋

    日本中性子科学会年会講演概要集　9th　58　2009

  25. 21pWE-5 Deformation of vesicles controlled by spontaneous curvatures of lipids

    Sakuma Yuka, Imai Masayuki, Kawakatsu Toshihiro, Taniguchi Takashi

    Meeting abstracts of the Physical Society of Japan　63　(2)　317-317　2008/08/25

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

  26. Dynamical Structure of Nano-Meter-Sized Domains on a Vesicle(Poster session 1, New Frontiers in Colloidal Physics : A Bridge between Micro- and Macroscopic Concepts in Soft Matter) :

    Sakuma Yuka, Masui Tomomi, Imai Masayuki, Urakami Naohito, Nagao Michihiro, Komura Shigeyuki

    89　(1)　45-45　2007

    Publisher: 物性研究刊行会

    ISSN： 0525-2997

  27. Adhesion of Binary Vesicles Induced by Phase Separation(Poster session 2, New Frontiers in Colloidal Physics : A Bridge between Micro- and Macroscopic Concepts in Soft Matter) :

    Sakuma Yuka, Imai Masayuki, Komura Shigeyuki

    89　(1)　116-116　2007

    Publisher: 物性研究刊行会

    ISSN： 0525-2997

  28. 25aWG-3 Binding transition of vesicles induced by lateral phase separation

    Sakuma Y., Imai M., Yanagisawa M., Komura S.

    Meeting abstracts of the Physical Society of Japan　61　(2)　273-273　2006/08/18

    Publisher: The Physical Society of Japan (JPS)

    ISSN： 1342-8349

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Books and Other Publications 3

  1. Encyclopedia of Polymeric Nanomaterials

    Yuka Sakuma, Masayuki Imai

    2015

  2. 生体膜の分子機構−リピッドワールドが先導する生命科学

    今井正幸, 佐久間由香

    化学同人　2014

    ISBN: 9784759815160

  3. Advances in Planar Lipid Bilayers and Liposomes

    M. Imai, Y. Sakuma

    2010

    ISBN: 9780123812667

Presentations 74

  1. Long-range viscosity of C. elegans plasma membrane

    Yuka Sakuma

    2025/10/01

  2. Long-Range Membrane Viscosity of Living Cell

    Yuka Sakuma

    Biophysical Society Thematic Meeting Beyond Simple Models: The Consequences of Membrane Complexity in Living Systems Meeting, Copenhagen, Denmark　2025/07/08

  3. Membrane viscosity of phase-separated ternary GUVs having Lo domains as the basis for lipid rafts

    Julia Tanaka, Yuka Sakuma

    2024/06/26

  4. Viscosity landscape of phase-separated ternary vesicles in composition-temperature space

    Julia Tanaka, Kenya Haga, Masayuki Imai, Yuka Sakuma

    2023/11/16

  5. Effect of polymer chains grafted on the phase-separated ternary GUVs on the membrane fluidity

    Yuka Sakuma

    2023/11/15

  6. Effect of polymer chains grafted to the lipid GUV on the membrane fluidity Invited

    Yuka Sakuma

    Advanced core-to-core network for the physics of self-organizing active matter kick off meeting, Kyoto, Japan　2023/09/11

  7. Membrane viscosity of ternary vesicles in a wide composition-temperature space

    Juria Tanaka, Kenya Haga, Masayuki Imai, Yuka Sakuma

    The 7th International Soft Matter Conference, Osaka, Japan　2023/09/06

  8. Effect of polymer chains grafted to the lipid GUV on the membrane fluidity

    Yuka Sakuma

    The 7th International Soft Matter Conference, Osaka, Japan　2023/09/05

  9. Membrane viscosity of polymer-grafted GUVs: Toward understanding the cell membrane fluidity Invited

    Yuka Sakuma

    9th International Discussion Meeting on Relaxations in Complex Systems, Chiba, Japan　2023/08/17

  10. Effect of grafted polymer chains on the membrane fluidity

    Yuka Sakuma

    Statphys28, Tokyo, Japan　2023/08/08

  11. 三価イオンによる膜張力制御が誘起するベシクルの接着・融合

    佐久間由香

    第９回ソフトマター研究会　2019/11/26

  12. 脂質三成分ベシクルの膜粘度マップ

    佐久間由香, 川勝年洋, 谷口貴志, 今井正幸

    第９回ソフトマター研究会　2019/11/26

  13. 化学刺激によるモデル生体膜の形態制御

    豊田真之, 佐久間由香, Nicolas Puff, Miglena Angela, 今井正幸

    ２０１９年日本物理学会秋季大会　2019/09/10

  14. 化学刺激によるベシクルの形態制御

    豊田真之, 佐久間由香, 今井正幸

    第８回ソフトマター研究会　2018/12/07

  15. 脂質の分子形状と相分離の結合によるベシクル膜変形 Invited

    佐久間 由香

    「ベシクルの変形の物理と数理」勉強会　2018/10/25

  16. 接着したベシクルの形態転移

    村上圭, 海老原隆太, 河野拓馬, 佐久間由香, 今井正幸, Primoz Ziherl

    日本物理学会2018年秋季大会　2018/09/10

  17. ベシクルと情報高分子の連携による自己複製システム

    栗栖実, 青木春隆, 佐久間由香, 今井正幸, Sandra Luginbhl, Peter Walde

    日本物理学会2018年春季大会　2018/03/23

  18. 鋳型重合と連携したベシクルの成長

    栗栖実, 青木春隆, 今井正幸, 佐久間由香, Peter Walde

    日本物理学会2017年秋季大会　2017/09/24

  19. ベシクルの自己生成過程の非平衡熱統計力学的アプローチ

    川勝年洋, 佐久間由香, 今井正幸

    日本物理学会2017年秋季大会　2017/09/23

  20. 接着したベシクルの変形解析

    海老原隆太, 河野拓馬, 佐久間由香, 今井正幸, Primoz Ziherl

    日本物理学会2017年秋季大会　2017/09/23

  21. Control of vesicle deformation toward protocell International-presentation

    Yuka SAKUMA

    International Conference THE ORIGIN OF LIFE　2017/05/29

  22. 膜状での鋳型高分子合成が誘起するベシクルダイナミクス

    青木春隆, 今井正幸, 佐久間由香, Peter Walde

    日本物理学会第７２回年次大会　2017/03/17

  23. 自己生産するベシクルの機構

    神保岳大, 佐久間由香, 今井正幸, 浦上直人, Primoz Ziherl, 菅原正

    日本物理学会第７２回年次大会　2017/03/17

  24. 金属イオンにより駆動されるリン脂質ベシクルの拡散泳動

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    日本物理学会第７２回年次大会　2017/03/17

  25. 化学刺激による脂質ベシクル膜面上での孔開閉の制御

    佐久間由香, 兒玉篤治, 今井正幸

    日本物理学会第７２回年次大会　2017/03/17

  26. MECHANISM OF SELF-REPRODUCING VESICLES International-presentation

    Takehiro Jimbo, Yuka Sakuma, Masayuki Imai, Naohito Urakami, Primoz Ziherl

    Biophysical Society 61st Annual Meeting　2017/02/11

  27. 1) 金属イオンにより駆動されるリン脂質ベシクルの拡散泳動

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    第６回ソフトマター研究会　2016/10/25

  28. Morphology of Multi-Cellular Model

    R. Ebihara, T. Kono, Y. Sakuma, M. Imai, P.Ziherl

    新学術領域「ゆらぎと構造の協奏」第３回領域研究会　2016/06/17

  29. Pore Formation in Vesicle Membranes Induced by Chemical Stimuli

    Y. Sakuma, A. Kodama, M. Imai

    新学術領域「ゆらぎと構造の協奏」第３回領域研究会　2016/06/17

  30. 化学刺激によるベシクル膜面上での孔形成

    佐久間由香, 兒玉篤治, 今井正幸

    日本物理学会第７１回年次大会　2016/03/19

  31. 接着したベシクルの形態形成

    河野拓馬, 海老原隆太, 佐久間由香, 今井正幸, Primoz Ziherl

    日本物理学会第７１回年次大会　2016/03/19

  32. 二価の陽イオンによるリン脂質ベシクルの駆動

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    第５回ソフトマター研究会　2015/12/17

  33. 自己生産ベシクルにおけるPE脂質の役割について

    神保岳大, 佐久間由香, 今井正幸, 浦上直人, Primož Ziherl

    第５回ソフトマター研究会　2015/12/17

  34. 多細胞モデルの形態形成

    河野拓馬, 海老原隆太, 佐久間由香, 今井正幸, Primoz Ziherl

    第５回ソフトマター研究会　2015/12/17

  35. 化学刺激によるリン脂質ベシクルの駆動

    兒玉篤治, 佐久間由香, 今井正幸, 大矢豊大, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    日本物理学会第２０１５年秋季大会　2015/09/16

  36. 二成分脂質ベシクルで探る生命と分子集合体の境界

    第５３回日本生物物理学会年会　2015/09/14

  37. Approach to Minimal Cell based on Membrane Physics International-presentation

    International Workshop on Challenge to Synthesizing Life　2015/08/25

  38. Physics of self-reproduction of vesicle reveal by 3D analysis International-presentation

    T. Jimbo, Y. Sakuma, P. Ziherl, M. Imai

    International Workshop on Challenge to Synthesizing Life　2015/08/25

  39. Migration of phospholipid vesicles in response to chemical stimuli International-presentation

    A. Kodama, Y. Sakuma, M. Imai, Y. Oya, T. Kawakatsu, N. Puff, M. I. Angelova

    International Symposium on Fluctuation and Structure out of Equilibrium 2015　2015/08/20

  40. A Key for self-reproduction of vesicles International-presentation

    T. Jimbo, Y. Sakuma, P. Ziherl, M. Imai

    International Symposium on Fluctuation and Structure out of Equilibrium 2015　2015/08/20

  41. pH刺激に対する脂肪酸ベシクルの応答

    五十里慶太, 佐久間由香, 今井正幸, P.-A.Monnard, S.Rasmussen

    日本物理学会第７０回年次大会　2015/03/21

  42. リン脂質ベシクルの化学駆動

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    新学術領域研究「ゆらぎと構造」領域横断の研究会「アクティブ・マター研究の過去・現在・未来」　2015/03/14

  43. リン脂質ベシクルの化学駆動とそれに伴う変形と破裂

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋, Nicolas Puff, Miglena I. Angelova

    第4回ソフトマター研究会　2015/01/06

  44. 三次元画像解析による二成分ベシクル自己生産機構の研究

    神保岳大, 佐久間由香, Primoz Ziherl, 今井正幸

    第4回ソフトマター研究会　2015/01/06

  45. 多細胞系モデルの形態変化

    河野拓馬, 佐久間由香, 今井正幸, Primoz Ziherl

    第4回ソフトマター研究会　2015/01/06

  46. 化学刺激に対するイオン性リン脂質の振る舞い

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋

    新学術領域「ゆらぎと構造の協奏」第2回領域研究会　2014/08/29

  47. ベシクルの自己生産の三次元画像解析

    神保岳大, 佐久間由香, Primoz Ziherl, 今井正幸

    新学術領域「ゆらぎと構造の協奏」第2回領域研究会　2014/08/29

  48. 4) 化学刺激に対する脂肪酸ベシクルの応答

    五十里慶太, 佐久間由香, 今井正幸, P.-A.Monnard, S.Rasmussen

    新学術領域「ゆらぎと構造の協奏」第2回領域研究会　2014/08/29

  49. Physical background of self-reproduction of vesicles International-presentation

    T. Jimbo, Y. Sakuma, P. Ziherl, M. Imai

    Open Questions on the Origin of Life 2014　2014/07/12

  50. ベシクルからプロトセルへのアプローチ

    佐久間由香, 今井正幸

    日本膜学会第36回年会　2014/05/12

  51. Binary Vesucles Having Functions of Protocell International-presentation

    Y. Sakuma, T. Jimbo, M. Imai

    International Workshop From Soft Matter to Protocell　2013/09/18

  52. Chemophoresis of Neutral Phospholipid Vesicle International-presentation

    A. Kodama, Y. Sakuma, M. Imai, T. Kawakatsu, N. Puff, M. I. Angelova

    International Workshop From Soft Matter to Protocell　2013/09/18

  53. From Vesicle to Protocell International-presentation

    Y. Sakuma, M. Imai

    245th ACS National Meeting and Exposition　2013/04/07

  54. 1) 化学刺激によるベシクル膜変形

    佐久間由香, A.-F. Bitbol, N. Puff, 今井正幸, J.-B. Fournier, M. I. Angelova

    日本物理学会第６８回年次大会　2013/03/26

  55. ソフトな球状粒子の結晶化ダイナミクス

    今井正幸, 佐久間由香

    日本物理学会第６８回年次大会　2013/03/26

  56. 中性リン脂質ベシクルの化学駆動

    兒玉篤治, 佐久間由香, 今井正幸, 川勝年洋

    日本物理学会第６８回年次大会　2013/03/26

  57. Vesicle deformation triggered by chemical stimulation International-presentation

    Y. Sakuma, M. Imai

    Self-organization and Emergent Dynamics in Active Soft Matter　2013/02/18

  58. Vesicle Dynamics Triggered by Chemical Stimuli International-presentation

    M. Imai, A. Kodama, Y. Sakuma, T. Kawakatsu

    German-Japan Workshop Soft Matter in Nonequilibrium　2013/02/16

  59. Molecular Assembly to Protocell International-presentation

    Y. Sakuma, ○M. Imai

    Japanese-German-French workshop “Physics of Active Soft Matter”　2012/09/24

  60. Self-Reproduction of Lipid Vesicles International-presentation

    Y. Sakuma, M. Imai

    Biomembrane Days in Potsdam　2012/09/19

  61. Self-Reproduction of Lipid Vesicles International-presentation

    Y. Sakuma, M. Imai

    Association in Solutions III Self-Assembly: From Bio-Colloids to Nano-Engineering　2012/07/23

  62. Molecular assembly to protocell International-presentation

    M. Imai, Y. Sakuma

    ECI conference:Association in Solutions III　2012/07/23

  63. Model Self-Reproducing Binary Vesicle International-presentation

    Y. Sakuma, M. Imai

    International Association of Colloid and Interface Scientists, Conference IACIS 2012　2012/05/13

  64. Slow Dynamics of Soft Spheres International-presentation

    M. Imai, M. Kurimoto, F. Matsuura, T. Kawakatsu, Y.Sakuma

    International Association of Colloid and Interface Scientists, Conference IACIS 2012　2012/05/13

  65. Model of Self Reproducing Vesicles International-presentation

    Y. Sakuma, M. Imai

    Biophysical Society 56th Annual Meeting　2012/02/25

  66. Asymmetric Distribution of Lipids Induced by Membrane Curvature International-presentation

    Y. Sakuma, M. Imai

    1st Asia-Oceania Conference on Neutron Scattering　2011/11/20

  67. 膜の曲率に応じた脂質分布の非対称性

    佐久間由香, 今井正幸

    日本物理学会第６６回年次大会　2011/09/21

  68. 脂質二成分ベシクルで再現する自己生産系

    佐久間由香, 今井正幸

    第１回ソフトマター研究会　2011/08/03

  69. Dynamics of Nanometer Sized Vesicles International-presentation

    Y. Sakuma, N. Urakami, M. Nagao, M. Imai

    4th Discussion Meeting on Glass Transition　2011/02/28

  70. 中性子小角散乱でみたベシクルの構造

    佐久間由香, 今井正幸

    東京大学物性研究所短期研究会「小角・反射率・高分解能装置研究会」　2011/02/07

  71. ベシクルのバーシングダイナミクス

    佐久間由香, 今井正幸

    日本物理学会第６５回年次大会　2010/09/23

  72. Cascade Birthing Dynamics of Vesicles International-presentation

    Y. Sakuma, M. Imai

    ISSP International Workshop on Soft Matter Physics　2010/08/23

  73. Diffusion of Domains on Nano-meter Sized Vesicle International-presentation

    Y. Sakuma, M. Imai, N. Urakami, Y. Ogata, M. Nagao, S. Komura, T. Kawakatsu

    International Conference of Neutron Scattering 2009　2009/05/03

  74. Adhesion of Binary Vesicles Containing Negative Spontaneous Curvature Lipids International-presentation

    Y. Sakuma, M. Imai, S. Komura, T. Kawakatsu

    International Workshop on "Physical Phenomena in Multi-Component Membranes　2008/03/17

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Industrial Property Rights 1

  1. ベシクル型キャリアー

    佐久間由香, 今井正幸

    特許第5423043号

    Property Type: Patent

Research Projects 10

  1. Boundary between non-living and living matter revealed by measuring the fluidity of "living" cell membranes

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2023/04/01 - 2027/03/31

  2. 「生きている」細胞膜の流動性測定から解明する非生命と生命の境界

    佐久間 由香

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2023/04/01 - 2027/03/31

  3. Evolvable Self-Reproducing Minimal Cells: Toward Artificial Living Systems

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2023/04/01 - 2026/03/31

  4. モデル系から生体系へのシステムアップデートによる生体膜の流動特性の解明

    佐久間 由香

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2020/04/01 - 2023/03/31

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    生体膜における代謝や信号伝達などの生体機能はタンパク質の膜内流動によって制御されている。このため、モデル生体膜（ベシクル）を用いた膜の流動特性の解明が行われてきたが、理論モデルにおける測定可能な膜粘度範囲の制限などから、その流動性の全景については未だ明らかになっていなかった。最近、研究代表者はベシクル膜面上にマイクロインジェクションにより局所的な力を加えることで引き起こされる膜流動パターンを、球面上での流体力学理論[Henle and Levine, Phys. Rev. E (2010)]と比較することにより膜粘度を計測する手法を開発した。この手法を用いて生体膜の主要構成成分である３種類の脂質分子(飽和リン脂質DPPC, 不飽和リン脂質DOPC, コレステロール CHOL)から成るベシクルの流動パターンを、相分離によってできるドメインの動きによって可視化し、組成と膜粘度の関係を測定した。その結果、膜粘度は組成により３桁に渡る広範囲で変化することが明らかになった[Sakuma et al., Biophys. J. (2020)]。 本研究では、モデル生体膜の非対称性などの条件を段階的に生体膜に近づけ、最終的には生体膜の粘度測定を行うことで流動特性を支配する要因の解明を目指す。2020年度は糖鎖に見立てた高分子(polyethyrene glycol：PEG)でベシクル表面を装飾した場合には装飾しないベシクルと比較して膜粘度が1桁程度高くなることを発見した。2021年度はベシクルを用いたボトムアップの立場からのアプローチに対して, 実際の生物の細胞を使ったトップダウンの立場から, 線虫の初期胚にベシクルと同様にマイクロインジェクションによって水流を与え, 膜流動の様子を観察した. この結果, 細胞骨格と細胞膜の間に強固な相互作用がはたらいていることがわかってきた.

  5. Non-Equilibrium Thermodynamic Conditions for Emergence of Life Revealed by Minimal Cells

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2020/04/01 - 2023/03/31

  6. Construction of Membrane Traffic Pathway by Chemical Stimuli

    Sakuma Yuka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2017/04/01 - 2020/03/31

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    Membrane traffic which is fundamental cell function shows membrane deformations such as adhesion, fusion or pore formation. The purpose of this study is to understand membrane deformations associated with cell functions from soft-matter physics point of view. Membrane deformations of lipid vesicle were reproduced by chemical stimuli using micro-injection method, and were compared with membrane elasticity model. As a result, it is revealed that membrane interactions or membrane tension can be controlled by microinjection of electrolytes to vesicles containing anionic lipid, which realize to membrane deformations relevant to cell functions(e.g. adhesion, fusion, pore formation and so on). In addition, membrane flow induced by microinjection was found in this study, which led to development of an unique technique to measure membrane viscosity for wide range of membrane compositions.

  7. Road from vesicles to protocells: metabolism, information, thermodynamics

    Imai Masayuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2016/04/01 - 2019/03/31

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    This research aims to construct minimal cell having essence of biological functions by using non-biological substances, so-called soft materials, whereby we reveal physics underlying the life. We focused on molecular assembly systems composed of synthesizing information polymer encoding vesicle membrane and growth-division vesicle coupled with the synthesis of information polymer. We succeeded to demonstrate the reproduction of vesicles coupled with an enzymatic polymerization reaction (synthesis polyaniline: PANI-ES) occurring on the surface of vesicles composed of AOT and cholesterol. An important characteristic of this reproduction system is that the AOT/cholesterol vesicles encourage the synthesis of PANI-ES and PANI-ES promotes the growth of AOT vesicles. This mutual promotion kinetics captures an essential feature of minimal cells.

  8. Physical approach from soft matter to artificial cell

    Imai Masayuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

    Institution: Tohoku University

    2013/06/28 - 2018/03/31

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    The purpose of this study is to create the molecular assembly (artificial cell) having the essential functions of cellular life (heredity using information molecules, metabolism, self-reproduction of container) and the self-propelling ability. We will reveal the physical background of the cellular life through the artificial cells. 1) We have succeeded to create two types of artificial cells. Both of them demonstrate the vesicle reproduction coupled with the information molecules. One of them shows a primitive model cell cycle comprising four discrete phases (ingestion, replication, maturity and division), i.e., repeatable cell division. Both artificial cell has a potential of heredity and evolvability through the information molecules. 2)We also succeeded to create self-propelled tubular vesicles triggered by chemical stimuli, where the migration is coupled with the wavy motion of the tube. These findings shed light on the way from the molecular assembly to the cellular life.

  9. Vesicle dynamics induced by chemical stimuli

    Sakuma Yuka

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2013/04/01 - 2017/03/31

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    To understand the response of molecular assemblies against chemical stimuli is essential for approaching cell dynamics, such as cell deformation and division, from soft matter physics point of view. In this study, I focused on the vesicle dynamics relevant to cell functions induced by chemical stimuli, especially pore formation that plays an important role in membrane traffic. I succeed to reproduce pore formation on the vesicle by injecting hydroxide ions to phospholipid vesicles containing anionic lipids. The interaction between anionic lipid and hydroxide ion decreases cross section area of lipids, which produces the surface tension and then pore formation. This chemical control of pore formation is a first step to reveal biological function non-equilibrium soft matter physics point of view.

  10. Physics of development from molecular assembly to protocell

    Imai Masayuki, SAKUMA Yuka, URAKAMI Naohito, SUZUKI Kentaro

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (A)

    Institution: Tohoku University

    2013/04/01 - 2016/03/31

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    in this research we have investigated vesicle dynamics triggered by chemical stimuli, which might be the first step of the evolution from vesicles to cellular life. By applying chemical stimuli, vesicles show unique dynamics, such as migration, deformations, relevant to biological functions. We revealed that chemical modifications of the surface tension and molecular cross section are responsible for the observed vesicle dynamics. In addition we succeeded to synthesize a new artificial lipid precursor molecule, which is hydrolyzed to produce the membrane molecule at the membrane surface. The membrane molecules are incorporated into the vesicle membrane and causes the vesicle growth.The growing vesicle produces offspring vesicles by division. The vesicle division process was investigated by a molecular dynamics simulation. the simulation revealed that the coupling of molecular shape and vesicle shape plays an important role in the vesicle division.

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Social Activities 6

  1. (公開講座) 「生きていること」を物理で理解する

    夢ナビ

    2025/08/04 - Present

  2. 第２回Keio Astrobiology Camp 2017

    2017/03/26 - 2017/03/28

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    日本全国の幅広い年代の学生（高校生，大学生，大学院生）を対象に、日本全国から集まった様々な分野を代表する新進気鋭の研究者たちとの交流やグループワークによる発表を通して、各自がアストロバイオロジーに対する理解を深めるとともに、知的好奇心を刺激し、将来の進路や研究のテーマを考える場を提供することを目的とする。

  3. （講演会等）細胞膜における相分離の役割, 一般向けの講義のライブ配信

    シリーズセミナー「相分離」第９回

    2025/05/22 -

  4. （公開講座）「生きている」を理解する, 高校生向けの講義のライブ配信

    ぶらりがくfor ハイスクール

    2025/03/22 -

  5. 微小カプセル 冷却で薬剤放出

    2012/02/28 -

  6. お茶の水女子大、冷やすと内部薬剤を放出するカプセル粒子を開発

    2011/12/05 -

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Academic Activities 1

  1. The 7th International Soft Matter Conference, Osaka, Japan

    2023/09/04 - 2023/09/08

    Activity type: Competition, symposium, etc.