Details of the Researcher

PHOTO

Tatsuma Okazaki
Section
Graduate School of Medicine
Job title
Associate Professor
Degree
Profile

リンパ管、血管、筋肉の視点から癌や高齢者肺炎を研究しています。

Research History 4

  • 2008 - 2011
    カナダ McGill 大学 Meakins Christies 研究所　Basil Petrof 研究室

  • 2006 - 2008
    米国 University of California San Francisco (UCSF)　解剖学教室 Donald McDonald 研究室

  • 2001 - 2006
    東北大学医学部老年・呼吸器内科

  • 1994 - 1997
    青森県八戸市八戸市民病院

Research Interests 5

  • 咳嗽力・咳反射

  • 味覚医療

  • 呼吸筋

  • 嚥下障害

  • 腫瘍免疫

Research Areas 1

  • Life sciences / Rehabilitation science /

Papers 122

  1. Combining Geriatric Nutritional Risk Index with Total Cholesterol to Predict Pneumonia Mortality Risks in a Cohort of General Older Adults. International-journal

    Rui Yu, Tatsuma Okazaki, Yilin Du, Naoki Suzuki, Takahiro Miura, Midori Miyagi, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara

    Nutrients　18　(3)　2026/01/30

    DOI： 10.3390/nu18030465 　

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    Background/Objectives: To examine the importance of a composite measure incorporating the Geriatric Nutritional Risk Index (GNRI) and total cholesterol (TC), termed TC-GNRI, in predicting pneumonia mortality in community-dwelling aged individuals. Methods: A longitudinal analysis of the Tsurugaya cohort in Japan, including 1124 participants aged 70 years or older, was used for tracking pneumonia-related deaths for an 11-year period. Total cholesterol thresholds were set at 171 mg/dL (males) and 192 mg/dL (females), classified into higher- and lower-groups. GNRI was divided into higher (≥100.64) and lower (<100.64) groups. A combined index (TC-GNRI) was then created by integrating these indices into three levels: high (both values at or above the thresholds), intermediate (one value above and one below), and low (both below). Cox proportional hazards models estimated hazard ratios (HRs) for pneumonia mortality, adjusting for age, gender, smoking, the Timed Up and Go test, %FVC, and tuberculosis, using high groups as references. Results: Kaplan-Meier curves showed that lower total cholesterol and lower GNRI were associated with higher pneumonia mortality than in the respective higher groups. The intermediate- and low-TC-GNRI groups had poorer survival rates than the high group. After adjustment, lower total cholesterol (HR = 3.03, 95% CI 1.41-6.52) and lower GNRI (HR = 2.69, 95% CI 1.21-5.99) were each associated with greater pneumonia mortality than the higher groups. The intermediate- (HR = 2.81, 95% CI 1.18-6.70) and low-TC-GNRI (HR = 6.17, 95% CI 2.15-17.74) groups showed greater pneumonia mortality than the high group. Conclusions: TC-GNRI may provide additional value in indicating pneumonia mortality risk than total cholesterol or GNRI alone. TC-GNRI may be a valuable tool for identifying older adults at particularly high risk of pneumonia mortality.

  2. Respiratory Muscle Force, Body Position, and Sarcopenic Indices: Correlations and Clinical Implications in Older Women. International-journal

    Rui Yu, Tatsuma Okazaki, Takahiro Miura, Midori Miyagi, Naoki Suzuki, Satoru Ebihara

    Journal of oral rehabilitation　2026/01/14

    DOI： 10.1111/joor.70148 　

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    BACKGROUND: Risk factors for aspiration pneumonia in aged adults include respiratory muscle weakness and ineffective coughing, which might be influenced by physical position and be associated with sarcopenia. OBJECTIVES: This investigation sought to elucidate the optimal physical position for maximising respiratory muscle force and cough effectiveness, to investigate correlations between respiratory muscle force and other sarcopenia-related parameters in older people, which remain largely unclear, and to search for a novel pneumonia prevention approach. METHODS: Twenty-six healthy older women were evaluated in six positions: supine (0°), 30° semi-recumbent, 60° semi-recumbent, 90° sitting, and 60° semi-recumbent with left/right trunk rotation. Maximum inspiratory and expiratory pressures, cough peak flow, respiratory function, tongue pressure, and self-assessed cough ease were measured. We analysed correlations between respiratory muscle force and other parameters. RESULTS: The 60° semi-recumbent position demonstrated significantly greater maximum inspiratory pressure, expiratory pressure, cough peak flow, and peak expiratory flow than supine and rotated positions. This position was rated subjectively easiest for coughing. Respiratory muscle strength showed moderate correlations with sarcopenia-related indices. Inspiratory muscle strength correlated with % predicted value forced vital capacity (%FVC; r = 0.509), quadriceps strength (r = 0.502), cough peak flow (r = 0.420), and handgrip strength (r = 0.371). CONCLUSIONS: The 60° semi-recumbent position optimised respiratory muscle force and cough effectiveness in older women, suggesting clinical implications for aspiration pneumonia prevention strategies. The link between respiratory and limb muscle indices possibly supported the concept of sarcopenia in respiratory muscles, suggesting its integration into approaches to pneumonia prevention and management.

  3. Bilateral Upper-Extremity Hybrid Assistive Limb Treatment for GNE Myopathy.

    Naoki Suzuki, Toshiaki Takahashi, Yoshihito Furusawa, Midori Miyagi, Takahiro Miura, Shun Takanaka, Shunta Yokouchi, Kota Ataka, Shota Soma, Yusuke Sekiguchi, Hiromitsu Oya, Kensuke Ikeda, Rumiko Izumi, Naoko Nakamura, Tomomi Shijo, Masaaki Kato, Chihiro Nakazawa, Keisuke Obata, Tatsuma Okazaki, Masashi Aoki, Satoru Ebihara

    The Tohoku journal of experimental medicine　2025/10/16

    DOI： 10.1620/tjem.2025.J108 　

  4. 下肢切断者の歩行獲得と骨格筋量および質との関連に関する後方視的観察研究

    小畑 景祐, 宮城 翠, 中澤 ちひろ, 芝崎 真人, 大屋 博充, 古澤 義人, 三浦 平寛, 鈴木 直輝, 岡崎 達馬, 海老原 覚

    日本筋学会学術集会プログラム・抄録集　11回　82-82　2025/08

    Publisher: (一社)日本筋学会

    ISSN： 2433-975X

  5. 遠位型ミオパチーに対する両上肢装着型サイボーグを用いたリハビリテーション治療

    鈴木 直輝, 古澤 義人, 宮城 翠, 三浦 平寛, 高橋 珠緒, 岡崎 達馬, 海老原 覚

    The Japanese Journal of Rehabilitation Medicine　62　(特別号)　S317-S317　2025/04

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  6. Impacts of High-Intensity One-Year Respiratory Muscle Exercise on Respiratory Muscle Force and Dyspnea at Various Body Trunk Angles in a Tetraplegic Patient.

    Tatsuma Okazaki, Ryo Takahashi, Taruhi Matsui, Midori Miyagi, Takahiro Miura, Naoki Suzuki, Satoru Ebihara

    The Tohoku journal of experimental medicine　2025/03/13

    DOI： 10.1620/tjem.2025.J037 　

  7. Nrf2 Deficiency Exacerbates the Decline in Swallowing and Respiratory Muscle Mass and Function in Mice with Aspiration Pneumonia. International-journal

    Hikaru Hashimoto, Tatsuma Okazaki, Yohei Honkura, Yuzhuo Ren, Peerada Ngamsnae, Takuma Hisaoka, Yasutoshi Koshiba, Jun Suzuki, Satoru Ebihara, Yukio Katori

    International journal of molecular sciences　25　(21)　2024/11/04

    DOI： 10.3390/ijms252111829 　

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    Aspiration pneumonia exacerbates swallowing and respiratory muscle atrophy. It induces respiratory muscle atrophy through three steps: proinflammatory cytokine production, caspase-3 and calpain, and then ubiquitin-proteasome activations. In addition, autophagy induces swallowing muscle atrophy. Nrf2 is the central detoxifying and antioxidant gene whose function in aspiration pneumonia is unclear. We explored the role of Nrf2 in aspiration pneumonia by examining swallowing and respiratory muscle mass and function using wild-type and Nrf2-knockout mice. Pepsin and lipopolysaccharide aspiration challenges caused aspiration pneumonia. The swallowing (digastric muscles) and respiratory (diaphragm) muscles were isolated. Quantitative RT-PCR and Western blotting were used to assess their proteolysis cascade. Pathological and videofluoroscopic examinations evaluated atrophy and swallowing function, respectively. Nrf2-knockouts showed exacerbated aspiration pneumonia compared with wild-types. Nrf2-knockouts exhibited more persistent and intense proinflammatory cytokine elevation than wild-types. In both mice, the challenge activated calpains and caspase-3 in the diaphragm but not in the digastric muscles. The digastric muscles showed extended autophagy activation in Nrf2-knockouts compared to wild-types. The diaphragms exhibited autophagy activation only in Nrf2-knockouts. Nrf2-knockouts showed worsened muscle atrophies and swallowing function compared with wild-types. Thus, activation of Nrf2 may alleviate inflammation, muscle atrophy, and function in aspiration pneumonia, a major health problem for the aging population, and may become a therapeutic target.

  8. Digital support for female students in physical education universities in Japan Peer-reviewed

    Junko Okuyama, Shuji Seto, Tomonori Motokawa, Tomomi Kato, Aya Miyamoto, Maki Maekawa, Shunichi Funakoshi, Tatsuma Okazaki, Satoru Ebihara

    2024/10/03

    Publisher: Springer Science and Business Media LLC

    DOI： 10.21203/rs.3.rs-4968008/v1 　

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    Abstract <p>At the age of university students, it is important to accomplish the developmental tasks of adolescents. Furthermore, in addition to acquiring specialized knowledge and accomplishing developmental tasks, athletic colleges also require young athletes to be active. Therefore, we decided to investigate the use of a smartphone application, me-fullness® as an unprecedented method of support for female college students currently enrolled in athletic colleges. We conducted a psychological survey of female university students at the International Pacific University in Okayama, Japan, before and after one month of use of a me-fullness® app (N = 125) and a group of non-users (N = 85). The app-using group showed significant improvement in depressive symptoms, anxiety symptoms and stress scores as indicated by the Depression, Anxiety and Stress Scale − 21 Items (DASS-21), as well as insomnia, Premenstrual Syndrome (PMS) and resilience scores, while the non-app-using group showed improvement in anxiety and resilience (by Wilcoxon signed-rank test). This study suggests that use of the me-fullness app may have improved depression, stress, insomnia, and resilience. We hope that this study will lead to better college life and sports performance for female students in athletic universities and colleges.</p>

  9. High‐intensity intermittent inspiratory and abdominal muscle combined training in respiratory, swallowing and systemic muscles of healthy adults

    Linlin Zhang, Tatsuma Okazaki, Satoru Ebihara, Shin‐Ichi Izumi

    Journal of Oral Rehabilitation　51　(9)　1805-1812　2024/05/30

    Publisher: Wiley

    DOI： 10.1111/joor.13761 　

    ISSN： 0305-182X

    eISSN： 1365-2842

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    Abstract Background Low‐intensity continuous inspiratory muscle training improves its strength. The abdominal muscles are the main expiratory muscles, and their training may improve expiratory muscle strength. Respiratory muscle strength regulates coughing effectiveness, which is critical for pneumonia management. In older people, risk factors for the development of pneumonia were respiratory muscle weakness and swallowing impairment. Currently, the impact of high‐intensity intermittent inspiratory and abdominal muscle combined training on the respiratory, swallowing, and systemic muscles is unclear. Objective We aimed to explore the effects of high‐intensity inspiratory muscle training combined with or without abdominal muscle training on respiratory muscle strength as well as the strength, mass, and performance of swallowing and systemic muscles. Methods Twenty‐eight healthy adults were divided into two groups. Participants performed high‐intensity intermittent inspiratory muscle single or its combination with abdominal muscle training for 4 weeks. Respiratory muscle strength, swallowing muscle strength and mass, systemic muscle strength, mass and performance were measured at baseline, Week 2 and Week 4. Results Both groups showed greater maximal respiratory pressures at Week 2 and Week 4 than baseline. Both groups showed improved tongue pressure and geniohyoid muscle thickness at Week 4. In addition, the combined training group improved body trunk muscle mass, handgrip strength and five‐time chair stand test, whereas the single training group did not. Conclusion This study revealed that high‐intensity inspiratory muscle training improved inspiratory muscle strength and swallowing muscle strength and mass. Moreover, inspiratory and abdominal muscle combined training showed an additional benefit of improving systemic muscle strength, mass and performance. Clinical Trial Registration Number UMIN000046724; https://upload.umin.ac.jp/cgi‐open‐bin/ctr/index.cgi?ctrno=UMIN000046724.

  10. Gait Acquisition with a Quadrilateral Socket after Ultra-short Transfemoral Amputation because of Staphylococcal Toxic Shock Syndrome.

    Naoki Suzuki, Midori Miyagi, Yoshihito Furusawa, Takahiro Miura, Takumi Agarie, Yuki Imaizumi, Chihiro Nakazawa, Tamao Takahashi, Keisuke Obata, Yumi Izumiyama, Kazunori Nishijima, Hiroyuki Miyauchi, Naoya Iwata, Tomoe Sobu, Yusuke Sekiguchi, Kota Ataka, Kumiko Takahashi, Masashi Takeuchi, Tatsuma Okazaki, Satoru Ebihara

    Progress in rehabilitation medicine　9　20240036-20240036　2024

    DOI： 10.2490/prm.20240036 　

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    BACKGROUND: Streptococcal toxic shock syndrome (STSS) is a notifiable disease under Japan's Infectious Disease Control Law and has become a pandemic following COVID-19. STSS often leads to necrotizing fasciitis, with a mortality rate exceeding 30%. Even in surviving patients, limb amputations are common. CASE: A 39-year-old woman developed STSS. She underwent 18 surgeries and vacuum-assisted closure therapy, which resulted in ultra-short right transfemoral amputation. With a strong desire to walk again, she began fitting for a provisional prosthesis 3 months post-amputation. Given the preserved hip muscle strength, an ultra-short transfemoral prosthesis was selected over a hip disarticulation prosthesis. The key components included a plug-in quadrilateral socket, a belt used to suspend the transfemoral prosthesis, a hydraulic knee joint, and an energy-storing foot. She regained walking ability using crutches. To address pain and skin issues in the stump load-bearing area, compression and adhesion were improved using thick fabric spats. Muscle mass, including that of the paraspinal muscles, was maintained during follow-up evaluations using computed tomography, dual-energy X-ray absorptiometry, and bioelectrical impedance analysis. The phantom limb pain in the right leg diminished with medication and prosthetic training. Her quality-of-life scores measured using the 36-item Short Form Questionnaire and the Prosthesis Evaluation Questionnaire also showed improvement. She was discharged home 5 months post-amputation. DISCUSSION: This case highlights the importance of high motivation, multidisciplinary collaboration, preservation of the trunk muscle reserve from pre-illness exercise habits, and early trunk rehabilitation to achieve successful gait acquisition with a customized transfemoral prosthesis.

  11. Effects of body postures on respiratory muscle force and coughing in healthy people

    Rui Yu, Tatsuma Okazaki, Yuzhuo Ren, Junko Okuyama, Satoru Ebihara, Shin-Ichi Izumi

    Respiratory Physiology &amp; Neurobiology　319　104181-104181　2024/01

    Publisher: Elsevier BV

    DOI： 10.1016/j.resp.2023.104181 　

    ISSN： 1569-9048

  12. Geriatric Nutritional Risk Index Predicts High Activities of Daily Living at Discharge in Older Patients with Heart Failure after Cardiac Rehabilitation. International-journal

    Yuta Muraoka, Takahiro Miura, Midori Miyagi, Tatsuma Okazaki, Taiki Katsumata, Keisuke Obata, Satoru Ebihara

    Journal of clinical medicine　12　(24)　2023/12/13

    DOI： 10.3390/jcm12247662 　

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    BACKGROUND: Hospitalization often leads to a decline in activities of daily living (ADL) in older patients with heart failure. Although cardiac rehabilitation (CR) improves ADL, it can be difficult to perform CR due to the deconditioning of these patients. This study aimed to examine the factors associated with ADL at discharge in older patients with heart failure who underwent CR. METHODS: A total of 86 of 110 older heart failure patients aged ≥ 75 years (average age, 86.9 ± 5.7 years) transferred to our institution for CR were enrolled and classified into high ADL at discharge (n = 54) and low ADL at discharge (n = 32) groups. Physical characteristics, comorbidities, medications, blood test data, echocardiographic data, and nutritional status (Geriatric Nutritional Risk Index [GNRI]) were retrospectively examined from medical records. ADL were assessed using the Barthel Index (BI) at admission and discharge. Considering multicollinearity, the relationship between high ADL (BI ≥ 60) at discharge and these assessments at admission was analyzed using multiple logistic regression analysis. The receiver operating characteristic curve was analyzed to calculate the cutoff values for the parameters identified by the multiple logistic regression analysis. RESULTS: The GNRI was the only independent factor predicting high ADL at discharge (p = 0.041; odds ratio [OR], 1.125; 95% confidence interval [CI], 1.005-1.260). The area under the receiver operating characteristic curve for the GNRI was 0.770 (95% CI, 0.664-0.876). The cutoff value for the GNRI was 83.4 (sensitivity, 85.2%; specificity, 62.5%). CONCLUSION: These findings suggest that the GNRI score at admission predicts high ADL at discharge in older patients with heart failure who underwent CR.

  13. Importance of Skeletal Muscle and Interdisciplinary Team Approach in Managing Pneumonia in Older People

    Satoru Ebihara, Tatsuma Okazaki, Keisuke Obata, Takae Ebihara

    Journal of Clinical Medicine　12　(15)　5093-5093　2023/08/03

    Publisher: MDPI AG

    DOI： 10.3390/jcm12155093 　

    eISSN： 2077-0383

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    Pneumonia is the most frequent lower respiratory tract disease and a major cause of morbidity and mortality globally [...]

  14. Impacts of body positions on the geniohyoid muscle contraction and swallowing difficulty in healthy adults. International-journal

    Fuwen Lu, Tatsuma Okazaki, Junko Okuyama, Shin-Ichi Izumi

    Clinical and experimental dental research　2023/07/05

    DOI： 10.1002/cre2.760 　

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    BACKGROUND: Body positions affect swallowing and gastroesophageal reflux. Swallowing impairment is one of the main causes of aspiration pneumonia. To prevent pneumonia, evaluation of body positions on gastroesophageal reflux recommended 30 degrees or higher semi-recumbent positions. The geniohypoid muscle and tongue play central roles in swallowing. However, the effects of body positions on contracting rates in the geniohyoid muscle and tongue pressure are unclear. Moreover, correlations between geniohyoid muscle contracting rates and subjective swallowing difficulties are unclear. AIMS: This study aimed to identify the proper body positions on contracting rates in the geniohyoid muscle, tongue pressure, and subjective swallowing difficulties. MATERIALS & METHODS: Twenty healthy adults swallowed 15- or 50 ml of water at 90 degrees sitting, 60- and 30 degrees semi-recumbent, and 0 degrees supine positions. We scored the subjective swallowing difficulties and measured the tongue pressure and the number of swallows. An ultrasound evaluated the geniohyoid muscle size and contracting rates. RESULTS: At sitting and 60 degrees semi-recumbent positions, the geniohyoid muscle showed greter contracting rates than at 30 degrees semi-recumbent and supine postions (P < 0.05), which resulted in easier swalloiwng. Greater tongue pressure was weakly correlated with fewer swallows (r = -0.339, P = 0.002), whereas the body positions did not affect. CONCLUSION: Considering swallowing and gastroesophageal reflux together, a trunk angle of 60 degrees or more might be beneficial for reducing the risk of aspiration.

  15. Anatomy and function of the lymphatic vessels in the parietal pleura and their plasticity under inflammation in mice. International-journal

    Yuzhuo Ren, Tatsuma Okazaki, Peerada Ngamsnae, Hikaru Hashimoto, Ryoukichi Ikeda, Yohei Honkura, Jun Suzuki, Shin-Ichi Izumi

    Microvascular research　148　104546-104546　2023/07

    DOI： 10.1016/j.mvr.2023.104546 　

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    Inflammatory pleuritis often causes pleural effusions, which are drained through lymphatic vessels (lymphatics) in the parietal pleura. The distribution of button- and zipper-like endothelial junctions can identify the subtypes of lymphatics, the initial, pre-collecting, and collecting lymphatics. Vascular endothelial growth factor receptor (VEGFR)-3 and its ligands VEGF-C/D are crucial lymphangiogenic factors. Currently, in the pleura covering the chest walls, the anatomy of the lymphatics and connecting networks of blood vessels are incompletely understood. Moreover, their pathological and functional plasticity under inflammation and the effects of VEGFR inhibition are unclear. This study aimed to learn the above-unanswered questions and immunostained mouse chest walls as whole-mount specimens. Confocal microscopic images and their 3-dimensional reconstruction analyzed the vasculatures. Repeated intra-pleural cavity lipopolysaccharide challenge induced pleuritis, which was also treated with VEGFR inhibition. Levels of vascular-related factors were evaluated by quantitative real-time polymerase chain reaction. We observed the initial lymphatics in the intercostals, collecting lymphatics under the ribs, and pre-collecting lymphatics connecting both. Arteries branched into capillaries and gathered into veins from the cranial to the caudal side. Lymphatics and blood vessels were in different layers with an adjacent distribution of the lymphatic layer to the pleural cavity. Inflammatory pleuritis elevated expression levels of VEGF-C/D and angiopoietin-2, induced lymphangiogenesis and blood vessel remodeling, and disorganized the lymphatic structures and subtypes. The disorganized lymphatics showed large sheet-like structures with many branches and holes inside. Such lymphatics were abundant in zipper-like endothelial junctions with some button-like junctions. The blood vessels were tortuous and had various diameters and complex networks. Stratified layers of lymphatics and blood vessels were disorganized, with impaired drainage function. VEGFR inhibition partially maintained their structures and drainage function. These findings demonstrate anatomy and pathological changes of the vasculatures in the parietal pleura and their potential as a novel therapeutic target.

  16. Association between Low Forced Vital Capacity and High Pneumonia Mortality, and Impact of Muscle Power. International-journal

    Nanako Shiokawa, Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Mana Kogure, Naoki Nakaya, Atsushi Hozawa, Satoru Ebihara, Shin-Ichi Izumi

    Journal of clinical medicine　12　(9)　2023/05/04

    DOI： 10.3390/jcm12093272 　

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    Impaired % predicted value forced vital capacity (% FVC) is related to higher all-cause mortality in aged adults, and strong muscle force may improve this relationship. A muscle disease, sarcopenia, causes higher mortality. We aimed to identify the unknown disease that relates impaired % FVC with higher mortality in aged adults among the three major leading causes of death, and the effect of strong leg force on this relationship. Cox proportional hazard model analyzed the longitudinal Tsurugaya cohort that registered 1048 aged Japanese for 11 years. The primary outcome was the relationship between % FVC and mortality by cancer, cardiovascular disease, or pneumonia. Exposure variables were % FVC or leg force divided by 80% or median values, respectively. The secondary outcome was the effects of leg force on the relationship. Among the diseases, % FVC < 80% was related only to higher pneumonia mortality (hazard ratio [HR], 4.09; 95% CI, 1.90-8.83) relative to the % FVC ≥ 80% group before adjustment. Adding the leg force as an explanatory variable reduced the HR to 3.34 (1.54-7.25). Weak leg force might indicate sarcopenia, and its prevention may improve higher pneumonia mortality risk related to impaired % FVC, which we may advise people in clinical settings.

  17. For establishment of the healthcare information booklet after Turkey-Syrian earthquake based on the past disaster

    Junko Okuyama, Shuji Seto, Yu Fukuda, Yoshimi Suzukamo, Tatsuma Okazaki, Yoshihito Furusawa, Shin-Ichi Izumi, Kiyoshi Ito, Fumihiko Imamura

    2023/04/06

    Publisher: Research Square Platform LLC

    DOI： 10.21203/rs.3.rs-2742385/v1 　

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    Abstract After a natural disaster, it is important to maintain the health of the victims, but after the Turkey-Syria earthquake, this information has not yet been provided. Tohoku University has compiled information on maintaining health care after the Great East Japan Earthquake of March 2011 into a booklet, which is available to the public. The purpose of this study is to investigate user satisfaction with this booklet. A total of 505 organizations participated in this study by completing questionnaires and evaluating the booklet. Quantitative responses were analyzed and coded by theme. Open-ended responses indicated that it was difficult for the general public to understand the data in the booklet. This study shows the need to keep in mind the ease of understanding for the general public when providing information on post-disaster care. We hope that this study will lead to better health care information for the victims of the Turkey-Syria earthquake.

  18. [Secondary Publication] 本邦の嚥下障害患者における,咽喉頭感覚評価法に関するアンケート調査

    神林 友紀, 加藤 健吾, 池田 怜吉, 鈴木 淳, 本藏 陽平, 平野 愛, 太田 淳, 加賀谷 斉, 井上 誠, 兵頭 政光, 大森 孝一, 末廣 篤, 岡崎 達馬, 出江 紳一, 小山 重人, 佐々木 啓一, 熊井 良彦, 二藤 隆春, 栗山 進一, 小川 武則, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　126　(3)　243-244　2023/03

    Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN： 2436-5793

    eISSN： 2436-5866

  19. Who treats older patients with aspiration pneumonia?

    Satoru Ebihara, Tatsuma Okazaki, Hisako Miura, Xinze Wu, Takae Ebihara

    Geriatrics & gerontology international　23　(3)　256-257　2023/03

    DOI： 10.1111/ggi.14547 　

  20. 地域在住高齢者における予測努力肺活量、死亡率および筋力の関連 鶴ヶ谷プロジェクト

    宮武 ミドリ, 岡崎 達馬, 鈴鴨 よしみ, 辻 一郎, 出江 紳一

    Journal of Epidemiology　33　(Suppl.1)　149-149　2023/02

    Publisher: (一社)日本疫学会

    ISSN： 0917-5040

    eISSN： 1349-9092

  21. 地域在住高齢者の予測努力肺活量と肺炎死の関連および筋力と血清総コレステロール値の影響

    汐川 菜々子, 岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 海老原 覚, 小暮 真奈, 中谷 直樹, 寳澤 篤, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　59　(秋季特別号)　S444-S444　2022/10

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  22. Anatomy and pathology of lymphatic vessels under physiological and inflammatory conditions in the mouse diaphragm. International-journal

    Peerada Ngamsnae, Tatsuma Okazaki, Yuzhou Ren, Yunxiang Xia, Hikaru Hashimoto, Ryoukichi Ikeda, Yohei Honkura, Yukio Katori, Shin-Ichi Izumi

    Microvascular research　145　104438-104438　2022/09/16

    DOI： 10.1016/j.mvr.2022.104438 　

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    The lymphatic vessels in the parietal pleura drain fluids. Impaired drainage function and excessive fluid entry in the pleural cavity accumulate effusion. The rat diaphragmatic lymphatics drain fluids from the pleura to the muscle layer. Lymphatic subtypes are characterized by the major distribution of discontinuous button-like endothelial junctions (buttons) in initial lymphatics and continuous zipper-like junctions (zippers) in the collecting lymphatics. Inflammation replaced buttons with zippers in tracheal lymphatics. In the mouse diaphragm, the structural relationship between the lymphatics and blood vessels, the presence of lymphatics in the muscle layer, and the distributions of initial and collecting lymphatics are unclear. Moreover, the endothelial junctional alterations and effects of vascular endothelial growth factor receptor (VEGFR) inhibition under pleural inflammation are unclear. We subjected the whole-mount mouse diaphragms to immunohistochemistry. The lymphatics and blood vessels were distributed in different layers of the pleural membrane. Major lymphatic subtypes were initial lymphatics in the pleura and collecting lymphatics in the muscle layer. Chronic pleural inflammation disorganized the stratified layers of the lymphatics and blood vessels and replaced buttons with zippers in the pleural lymphatics, which impaired drainage function. VEGFR inhibition under inflammation maintained the vascular structures and drainage function. In addition, VEGFR inhibition maintained the lymphatic endothelial junctions and reduced the blood vessel permeability under inflammation. These findings may provide new targets for managing pleural effusions caused by inflammation, such as pleuritis and empyema, which are common pneumonia comorbidities.

  23. High Mortality in an Older Japanese Population with Low Forced Vital Capacity and Gender-Dependent Potential Impact of Muscle Strength: Longitudinal Cohort Study. International-journal

    Midori Miyatake, Tatsuma Okazaki, Yoshimi Suzukamo, Sanae Matsuyama, Ichiro Tsuji, Shin-Ichi Izumi

    Journal of clinical medicine　11　(18)　2022/09/06

    DOI： 10.3390/jcm11185264 　

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    Generally, weak muscle power is associated with high mortality. We aimed to evaluate the unknown association between % predicted value forced vital capacity (FVC% predicted) and mortality in asymptomatic older people, and the impact of muscle power on this association. We analyzed the Tsurugaya cohort that enrolled Japanese people aged ≥70 for 15 years with Cox proportional hazards model. Exposure variables were FVC% predicted and leg power. The outcome was all-cause mortality. The subjects were divided into quartiles by FVC% predicted or leg power, or into two groups by 80% for FVC% predicted or by the strongest 25% for leg power. Across 985 subjects, 262 died. The males with lower FVC% predicted exhibited higher mortality risks. The hazard ratio (HR) was 2.03 (95% CI 1.30-3.18) at the lowest relative to the highest groups. The addition of leg power reduced the HR to 1.78 (95% CI 1.12-2.80). In females, FVC% predicted under 80% was a risk factor and the HR was 1.67 (95% CI 1.05-2.64) without the effect of leg power. In FVC% predicted &lt;80% males HRs were 2.44 (95% CI 1.48-4.02) in weak and 1.38 (95% CI 0.52-3.64) in strong leg power males, relative to ≥80% and strong leg power males. Low FVC% predicted was associated with high mortality with potential unfavorable effects of weak leg power in males.

  24. Implicit Body Representation of the Hand Enlarged by Repetitive Peripheral Magnetic Stimulation within the Boundary of a Real Hand

    Yunxiang Xia, Tatsuma Okazaki, Kenya Uemura, Shinichi Izumi

    Applied Sciences　12　(10)　5250-5250　2022/05/23

    Publisher: MDPI AG

    DOI： 10.3390/app12105250 　

    eISSN： 2076-3417

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    Deafferentation induced by local anesthesia causes a larger perceived area than the real area of the mouth, which, in the perspective of body representation, belongs to implicit body representation. In this study, we applied repetitive peripheral magnetic stimulation (rPMS) on the motor branch of the radial nerve of participants’ non-dominant-side forearm to induce extension movements of wrist and fingers. This intervention was supposed to increase proprioception to the brain and had an enlargement effect on implicit body representation of the hand in our hypothesis. A total of 39 participants were randomly allocated to the real rPMS group (n = 19) or the sham rPMS group (n = 20). Implicit representation of the hand was measured by a simplified paradigm based on the proposal of Longo and Haggard that depicted perceived locations of fingertips and metacarpophalangeal joints of participants’ occluded hand, in which they showed that implicit body representation of the hand was smaller than the real hand. We compare the main effect of real rPMS vs. sham rPMS and its interaction effect with time by setting four timepoints—before stimulation, right after stimulation, 10 min after stimulation and 20 min after stimulation—to demonstrate the possible short-lasting effect. Results showed that real rPMS had a short-lasting enlargement effect on implicit representation of the hand in general, which was significant especially on the ulnar side of fingers. What is more, the enlarged implicit body representation of the hand was still within the boundary of a real hand, which might indicate the identification role of a real body part.

  25. Frequent Onsets of Cellulitis in Lower Limbs with Lymphedema Following COVID-19 mRNA Vaccination. International-journal

    Tatsuma Okazaki, Momoko Matashiro, Gaku Kodama, Takeshi Tshubota, Yoshihito Furusawa, Shin-Ichi Izumi

    Vaccines　10　(4)　2022/03/26

    DOI： 10.3390/vaccines10040517 　

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    Four patients with secondary lower limb lymphedema developed cellulitis at their lymphedema lesion following COVID-19 mRNA vaccinations. They did not develop adverse effects at their vaccination site. All the patients were Japanese females aged &lt;60 years. Three patients developed cellulitis following the first vaccination. The date of onset of cellulitis following the first vaccination varied from 0 to 21 days. Two received BNT162b2 mRNA vaccines and the others received mRNA-1273 vaccines. All the patients were treated with oral antibiotics and recovered. Two patients had repeated cellulitis. The patients with the repeated development of cellulitis could not perform good skincare. One patient had joint contractures in their lower limbs and could not reach her lymphedema lesions, and the other patient could not master the skincare. According to previous studies, the development of cellulitis following vaccination was rare. In this study, four patients aged &lt;60 years developed cellulitis among the eight patients that regularly visited our hospital for rehabilitation for their lower limb lymphedema. In patients with lymphedema, prolonged inflammation may impair lymphatic functions and worsen edema. Therefore, at the time of vaccination, we should keep in mind the prevention and immediate management of cellulitis using intensive skincare and antibiotic treatment.

  26. 高齢者診療Up To Date(No.7) サルコペニアとフレイル診療

    岡崎 達馬, 出江 紳一

    新薬と臨牀　70　(12)　1519-1524　2021/12

    Publisher: (株)医薬情報研究所

    ISSN： 0559-8672

  27. 【呼吸リハビリテーションの新しい展開】誤嚥性肺炎

    岡崎 達馬, 出江 紳一

    総合リハビリテーション　49　(11)　1053-1057　2021/11

    Publisher: (株)医学書院

    ISSN： 0386-9822

    eISSN： 1882-1340

  28. 嚥下サルコペニア-栄養障害と誤嚥性肺炎 誤嚥性肺炎とサルコペニア

    岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 出江 紳一

    日本老年医学会雑誌　58　(Suppl.)　86-86　2021/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  29. 高齢者リハビリテーションの進歩 末梢神経磁気刺激装置による機能回復リハビリテーションの開拓とリンパ管を対象とした新規リハビリテーション開発の探索

    岡崎 達馬, ピーラダガサムネ, 任 雨卓, 出江 紳一

    日本老年医学会雑誌　58　(Suppl.)　108-108　2021/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  30. サルコペニア、嚥下障害、誤嚥性肺炎をめぐる最新の知見 誤嚥性肺炎とサルコペニア

    岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　58　(特別号)　JSY27-2　2021/05

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  31. 【ますます増える誤嚥性肺炎診療の最前線】誤嚥性肺炎とサルコペニア・フレイル・栄養

    岡崎 達馬, 出江 紳一

    日本医師会雑誌　149　(12)　2157-2160　2021/03

    Publisher: (公社)日本医師会

    ISSN： 0021-4493

  32. Respiratory Muscle Weakness as a Risk Factor for Pneumonia in Older People

    Tatsuma Okazaki, Yoshimi Suzukamo, Midori Miyatake, Riyo Komatsu, Masahiro Yaekashiwa, Mayumi Nihei, Shinichi Izumi, Takae Ebihara

    Gerontology　1-10　2021/02/23

    Publisher: S. Karger AG

    DOI： 10.1159/000514007 　

    ISSN： 0304-324X

    eISSN： 1423-0003

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    Introduction: The respiratory muscle strength regulates the effectiveness of coughing, which clears the airways and protects people from pneumonia. Sarcopenia is an aging-related loss of muscle mass and function, the worsening of which is associated with malnutrition. The loss of respiratory and swallowing muscle strength occurs with aging, but its effect on pneumonia is unclear. This study aimed to determine the risks of respiratory muscle weakness on the onset and relapse of pneumonia in older people in conjunction with other muscle-related factors such as malnutrition. Methods: We conducted a longitudinal study with 47 pneumonia inpatients and 35 non-pneumonia controls aged 70 years and older. We evaluated the strength of respiratory and swallowing muscles, muscle mass, and malnutrition (assessed by serum albumin levels and somatic fat) during admission and confirmed pneumonia relapse within 6 months. The maximal inspiratory and expiratory pressures determined the respiratory muscle strength. Swallowing muscle strength was evaluated by tongue pressure. Bioelectrical impedance analysis was used to evaluate the muscle and fat mass. Results: The respiratory muscle strength, body trunk muscle mass, serum albumin level, somatic fat mass, and tongue pressure were significantly lower in pneumonia patients than in controls. Risk factors for the onset of pneumonia were low inspiratory respiratory muscle strength (odds ratio [OR], 6.85; 95% confidence interval [CI], 1.56–30.11), low body trunk muscle mass divided by height2 (OR, 6.86; 95% CI, 1.49–31.65), and low serum albumin level (OR, 5.46; 95% CI, 1.51–19.79). For the relapse of pneumonia, low somatic fat mass divided by height2 was a risk factor (OR, 20.10; 95% CI, 2.10–192.42). Discussion/Conclusions: Respiratory muscle weakness, lower body trunk muscle mass, and malnutrition were risk factors for the onset of pneumonia in older people. For the relapse of pneumonia, malnutrition was a risk factor.

  33. リハビリテーション医学研究のこれから 障害の多面的理解

    森 隆行, 岡崎 達馬, 鈴鴨 よしみ, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　58　(2)　192-194　2021/02

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  34. Questionnaire survey on pharyngolaryngeal sensation evaluation regarding dysphagia in Japan

    Tomonori Kambayashi, Kengo Kato, Ryoukichi Ikeda, Jun Suzuki, Yohei Honkura, Ai Hirano-Kawamoto, Jun Ohta, Hitoshi Kagaya, Makoto Inoue, Masamitsu Hyodo, Koichi Omori, Atsushi Suehiro, Tatsuma Okazaki, Shin-Ichi Izumi, Shigeto Koyama, Keiichi Sasaki, Yoshihiko Kumai, Takaharu Nito, Shinichi Kuriyama, Takenori Ogawa, Yukio Katori

    Auris Nasus Larynx　2021/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.anl.2021.01.022 　

    ISSN： 0385-8146

  35. 【嚥下障害パンデミックに挑む最新リハビリテーション医学・医療】嚥下障害とサルコペニアの最新知見

    岡崎 達馬, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　58　(1)　19-23　2021/01

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  36. Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan. International-journal

    Jun Suzuki, Ryoukichi Ikeda, Kengo Kato, Risako Kakuta, Yuta Kobayashi, Akira Ohkoshi, Ryo Ishii, Ai Hirano-Kawamoto, Jun Ohta, Rei Kawata, Tomonori Kanbayashi, Masaki Hatano, Tadahisa Shishido, Yuya Miyakura, Kento Ishigaki, Yasunari Yamauchi, Miho Nakazumi, Takuya Endo, Hiroki Tozuka, Shiori Kitaya, Yuki Numano, Shotaro Koizumi, Yutaro Saito, Mutsuki Unuma, Ken Hashimoto, Eiichi Ishida, Toshiaki Kikuchi, Takayuki Kudo, Kenichi Watanabe, Masaki Ogura, Masaru Tateda, Takatsuna Sasaki, Nobuo Ohta, Tatsuma Okazaki, Yukio Katori

    PloS one　16　(7)　e0254261　2021

    DOI： 10.1371/journal.pone.0254261 　

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    BACKGROUND: Pneumonia is a common cause of illness and death of the elderly in Japan. Its prevalence is escalating globally with the aging of population. To describe the latest trends in pneumonia hospitalizations, especially aspiration pneumonia (AP) cases, we assessed the clinical records of pneumonia patients admitted to core acute care hospitals in Miyagi prefecture, Japan. METHODS: A retrospective multi-institutional joint research was conducted for hospitalized pneumonia patients aged ≥20 years from January 2019 to December 2019. Clinical data of patients were collected from the medical records of eight acute care hospitals. RESULTS: Out of the 1,800 patients included in this study, 79% of the hospitalized pneumonia patients were aged above 70 years. The most common age group was in the 80s. The ratio of AP to total pneumonia cases increased with age, and 692 out of 1,800 patients had AP. In univariate analysis, these patients had significantly older ages, lower body mass index (BMI), a lower ratio of normal diet intake and homestay before hospitalization, along with more AP recurrences and comorbidities. During hospitalization, AP patients had extended fasting periods, more swallowing assessments and interventions, longer hospitalization, and higher in-hospital mortality rate than non-AP patients. A total of 7% and 2% AP patients underwent video endoscopy and video fluorography respectively. In multivariate analysis, lower BMI, lower C-reactive protein, a lower ratio of homestay before hospitalization, a higher complication rate of cerebrovascular disease, dementia, and neuromuscular disease were noted as a characteristic of AP patients. Swallowing interventions were performed for 51% of the AP patients who had been hospitalized for more than two weeks. In univariate analysis, swallowing intervention improved in-hospital mortality. Lower AP recurrence before hospitalization and a lower ratio of homestay before hospitalization were indicated as characteristics of AP patients of the swallowing intervention group from multivariate analysis. Change in dietary pattern from normal to modified diet was observed more frequently in the swallowing intervention group. CONCLUSION: AP accounts for 38.4% of all pneumonia cases in acute care hospitals in Northern Japan. The use of swallowing evaluations and interventions, which may reduce the risk of dysphagia and may associate with lowering mortality in AP patients, is still not widespread.

  37. 呼吸筋のサルコペニアと低栄養は高齢者肺炎発症と再発の危険因子である 横断コホート研究

    岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 八重柏 政宏, 二瓶 真由美, 出江 紳一, 海老原 孝枝

    日本呼吸器学会誌　9　(増刊)　242-242　2020/08

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  38. 呼吸筋力低下と低栄養は高齢者肺炎発症と再発の危険因子である

    岡崎 達馬, 海老原 孝枝, 鈴鴨 よしみ, 宮武 ミドリ, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　57　(特別号)　2-1　2020/07

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  39. 呼吸筋のサルコペニアと低栄養は高齢者肺炎発症と再発の危険因子である 横断コホート研究

    岡崎 達馬, 鈴鴨 よしみ, 宮武 ミドリ, 永井 久美子, 庄司 真美, 小松 理世, 神崎 恒一, 出江 紳一, 海老原 孝枝

    日本老年医学会雑誌　57　(Suppl.)　80-80　2020/07

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  40. 高齢者の嚥下機能低下と栄養不良の相互関係 高齢者誤嚥性肺炎と栄養

    海老原 孝枝, 岡崎 達馬, 唐帆 健吾, 道脇 幸博, 大石 雅子, 神崎 恒一

    日本老年医学会雑誌　57　(Suppl.)　34-34　2020/07

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  41. 【ポリファーマシー対策の実践法】嚥下障害におけるポリファーマシー対策 Peer-reviewed

    岡崎 達馬, 出江 紳一

    老年内科　1　(2)　155-159　2020/02

    Publisher: (有)科学評論社

    ISSN： 2435-1881

  42. Association between sarcopenia and pneumonia in older people. Peer-reviewed

    Tatsuma Okazaki, Satoru Ebihara, Takashi Mori, Shinichi Izumi, Takae Ebihara

    Geriatrics & gerontology international　20　(1)　7-13　2020/01

    DOI： 10.1111/ggi.13839 　

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    Pneumonia is a major cause of death in older people, and the number of such deaths is increasing. Present guidelines for pneumonia management are based on a pathogen-oriented strategy that relies on the optimal application of antibiotics. Older pneumonia inpatients show the high incidence of aspiration pneumonia. The main cause of aspiration pneumonia is an impairment in the swallowing and cough reflexes. These facts suggest a limitation of present management strategies and a requirement for new strategies for aspiration pneumonia. Sarcopenia is the loss of muscle strength and mass, and declining physical function with aging. Recently, a decrease in the mass or strength of the swallowing muscles was suggested to be associated with reduced swallowing function. Accordingly, dysphagia caused by sarcopenia of the systemic and swallowing-related muscles was named sarcopenic dysphagia. Presently, few studies have shown associations between aspiration pneumonia and sarcopenic dysphagia. As for the cough reflex, strong cough prevents aspiration pneumonia, and its strength is regulated by respiratory muscles. A few studies have reported a relationship between muscles and pneumonia in older people. Sarcopenia is a risk factor for pneumonia in older people, and aspiration pneumonia inpatients with low muscle mass show high mortality rates. Aspiration pneumonia induced muscle atrophy in respiratory, swallowing, and skeletal muscles in an animal model and humans. Associations between respiratory muscle strength and pneumonia are currently under investigation. Evaluation and management of sarcopenia could potentially become a new strategy to prevent and treat pneumonia in older patients, and research has only recently been launched. Geriatr Gerontol Int 2020; 20: 7-13.

  43. 超高齢化社会におけるsarcopenic dysphagiaについて 嚥下関連肺炎との関係

    岡崎 達馬, 海老原 孝枝, 森 隆志, 出江 紳一

    日本摂食・嚥下リハビリテーション学会雑誌　23　(3)　S8-S9　2019/12

    Publisher: (一社)日本摂食嚥下リハビリテーション学会

    ISSN： 1343-8441

    eISSN： 2434-2254

  44. 超高齢化社会におけるsarcopenic dysphagiaについて 嚥下関連肺炎との関係

    岡崎 達馬, 海老原 孝枝, 森 隆志, 出江 紳一

    日本摂食・嚥下リハビリテーション学会雑誌　23　(3)　S8-S9　2019/12

    Publisher: (一社)日本摂食嚥下リハビリテーション学会

    ISSN： 1343-8441

    eISSN： 2434-2254

  45. Ultrasonography to detect age-related changes in swallowing muscles Peer-reviewed

    Takashi Mori, Shinichi Izumi, Yoshimi Suzukamo, Tatsuma Okazaki, Susumu Iketani

    European Geriatric Medicine　10　(5)　753-760　2019/10/01

    DOI： 10.1007/s41999-019-00223-y 　

    ISSN： 1878-7649

    eISSN： 1878-7657

  46. Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas Peer-reviewed

    Yoko Tsukita, Naoya Fujino, Eisaku Miyauchi, Ryoko Saito, Fumiyoshi Fujishima, Koji Itakura, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Tatsuma Okazaki, Hisatoshi Sugiura, Akira Inoue, Yoshinori Okada, Masakazu Ichinose

    Molecular Cancer　18　(1)　24-1885　2019/02/11

    Publisher: (一社)日本癌学会

    DOI： 10.1186/s12943-019-0953-y 　

    ISSN： 0546-0476

    eISSN： 1476-4598

  47. Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5. International-journal Peer-reviewed

    Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose

    Oncoimmunology　8　(2)　e1543526　2019

    DOI： 10.1080/2162402X.2018.1543526 　

    ISSN： 2162-4011

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    Tumor-associated blood vessels and lymphatics are abnormal and dysfunctional. These are hallmarks of the tumor microenvironment, which has an immunosuppressive nature, such as through hypoxia. Treatment with anti-death receptor5 (DR5) monoclonal antibody MD5-1, which induces tumor cell death, is a potent anti-tumor immunotherapy. Generally, MD5-1 induces cell death mainly via antigen presenting cells (APCs) and generates tumor-specific effector T cells. To date, the effects of a simultaneous functional improvement of abnormal blood vessels and lymphatics on the immune microenvironment are largely unknown. A combination therapy using sunitinib, vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor inhibitor, and MD5-1 substantially inhibited tumor growth. Sunitinib improved pericyte coverage on endothelial cells and the expression levels of regulator of G-protein signaling 5, suggesting blood vessel normalization. Sunitinib also increased lymph flow from tumors to central lymph nodes, suggesting improved lymphatic function. In concordance with improved vasculature functions, sunitinib alleviated the tumor hypoxia, suggesting an improved tumor microenvironment. Indeed, the combination therapy induced strong activation of CD8+ T cells and dendritic cells in draining lymph nodes. The combination therapy reduced the ratio of immune-suppressive T regulatory cells in the tumors and draining lymph nodes. The combination therapy enhanced the numbers and activation of tumor-infiltrating CD8+ T cells. CD4 and/or CD8 depletion, or APC inhibiting experiments showed the contribution of CD8+ T cells and APCs to the combination therapy. These findings suggest that targeting blood vessels and lymphatics may have potential benefits for immunotherapy mediated by CD8+ T cells and APCs.

  48. TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells. International-journal Peer-reviewed

    Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M

    Experimental physiology　103　(11)　1543-1559　2018/11

    DOI： 10.1113/EP087221 　

    ISSN： 0958-0670

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    NEW FINDINGS: What is the central question of this study? Does Toll-like receptor 7 (TLR7) have any direct effects on Ca2+ -dependent physiological function of tracheal submucosal gland cells? What is the main finding and its importance? TLR7 is co-localized with SERCA2 in tracheal submucosal gland cells and causes a rapid attenuation of acetylcholine (ACh)-induced, Ca2+ -dependent ionic currents through the activation of SERCA2-dependent Ca2+ clearance. TLR7 is abundantly expressed in the airways of both swine and healthy human subjects, but is significantly downregulated in chronic obstructive pulmonary disease (COPD) airways. These findings suggest that a dysfunction of TLR7 in COPD removes the brake on ACh-induced serous secretion during viral infections, resulting in prolonged airway hypersecretion, and that it is one of the triggers of COPD exacerbations. ABSTRACT: Airway surface fluids are mainly secreted from submucosal glands (SMGs) and play important roles in the defence of airways via the activation of mucociliary transport. Toll-like receptor 7 (TLR7) recognizes and eliminates single stranded RNA (ssRNA) viruses through the induction of innate immunity. However, there is no obvious connection between TLR7 and mucus secretion, aside from TLR7 recognizing ssRNA viruses, which are often associated with airway hypersecretion in chronic obstructive pulmonary disease (COPD). Here, we investigated whether TLR7 has any direct effects on the Ca2+ -dependent physiological function of tracheal SMG cells. Patch-clamp analyses revealed that TLR7 ligand inhibited the acetylcholine (ACh)-induced ionic currents in isolated tracheal SMG cells. Intracellular calcium assays and pharmacological analyses revealed that TLR7 attenuated the transient rises in the intracellular calcium concentration evoked by ACh by activating sarco/endoplasmic reticulum Ca2+ -ATPase 2 (SERCA2). Immunofluorescence staining and immunohistochemical staining revealed that TLR7 was co-localized with SERCA2. These findings suggest that the activation of TLR7 during viral infections contributes to the rapid attenuation of ACh-induced ionic currents through an increase in SERCA2-dependent Ca2+ clearance in healthy airway SMG cells. Our study also revealed that TLR7 expression was significantly downregulated in COPD airways. Based on these findings, we speculate that a dysfunction of TLR7 may not only have an adverse effect on the elimination of these viruses but also remove the brake on ACh-induced serous secretion, resulting in prolonged hypersecretion and acting as one of the triggers of COPD exacerbations.

  49. Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. International-journal Peer-reviewed

    Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose

    Journal of cachexia, sarcopenia and muscle　9　(4)　643-653　2018/08

    DOI： 10.1002/jcsm.12297 　

    ISSN： 2190-5991

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    BACKGROUND: Repetition of the onset of aspiration pneumonia in aged patients is common and causes chronic inflammation. The inflammation induces proinflammatory cytokine production and atrophy in the muscles. The proinflammatory cytokines induce muscle proteolysis by activating calpains and caspase-3, followed by further degradation by the ubiquitin-proteasome system. Autophagy is another pathway of muscle atrophy. However, little is known about the relationship between aspiration pneumonia and muscle. For swallowing muscles, it is not clear whether they produce cytokines. The main objective of this study was to determine whether aspiration pneumonia induces muscle atrophy in the respiratory (the diaphragm), skeletal (the tibialis anterior, TA), and swallowing (the tongue) systems, and their possible mechanisms. METHODS: We employed a mouse aspiration pneumonia model and computed tomography (CT) scans of aged pneumonia patients. To induce aspiration pneumonia, mice were inoculated with low dose pepsin and lipopolysaccharide solution intra-nasally 5 days a week. The diaphragm, TA, and tongue were isolated, and total RNA, proteins, and frozen sections were stored. Quantitative real-time polymerase chain reaction determined the expression levels of proinflammatory cytokines, muscle E3 ubiquitin ligases, and autophagy related genes. Western blot analysis determined the activation of the muscle proteolysis pathway. Frozen sections determined the presence of muscle atrophy. CT scans were used to evaluate the muscle atrophy in aged aspiration pneumonia patients. RESULTS: The aspiration challenge enhanced the expression levels of proinflammatory cytokines in the diaphragm, TA, and tongue. Among muscle proteolysis pathways, the aspiration challenge activated caspase-3 in all the three muscles examined, whereas calpains were activated in the diaphragm and the TA but not in the tongue. Activation of the ubiquitin-proteasome system was detected in all the three muscles examined. The aspiration challenge activated autophagy in the TA and the tongue, whereas weak or little activation was detected in the diaphragm. The aspiration challenge resulted in a greater proportion of smaller myofibers than in controls in the diaphragm, TA, and tongue, suggesting muscle atrophy. CT scans clearly showed that aspiration pneumonia was followed by muscle atrophy in aged patients. CONCLUSIONS: Aspiration pneumonia induced muscle atrophy in the respiratory, skeletal, and swallowing systems in a preclinical animal model and in human patients. Diaphragmatic atrophy may weaken the force of cough to expectorate sputum or mis-swallowed contents. Skeletal muscle atrophy may cause secondary sarcopenia. The atrophy of swallowing muscles may weaken the swallowing function. Thus, muscle atrophy could become a new therapeutic target of aspiration pneumonia.

  50. Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease Peer-reviewed

    Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose

    International Journal of COPD　13　1333-1342　2018/04

    DOI： 10.2147/COPD.S157035 　

    ISSN： 1176-9106

    eISSN： 1178-2005

  51. Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease Peer-reviewed

    Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose

    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE　13　1333-1342　2018

    DOI： 10.2147/COPD.S157035 　

    ISSN： 1178-2005

  52. Production of reactive persulfide species in chronic obstructive pulmonary disease Peer-reviewed

    Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

    THORAX　72　(12)　1074-1083　2017/12

    DOI： 10.1136/thoraxjnl-2016-209359 　

    ISSN： 0040-6376

    eISSN： 1468-3296

  53. Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease Peer-reviewed

    Katsuhiro Onodera, Hisatoshi Sugiura, Mitsuhiro Yamada, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Rie Tanaka, Tadahisa Numakura, Shinsaku Togo, Kei Sato, Yorihiko Kyogoku, Yuichiro Hashimoto, Tatsuma Okazaki, Tsutomu Tamada, Seiichi Kobayashi, Masaru Yanai, Motohiko Miura, Yasushi Hoshikawa, Yoshinori Okada, Satoshi Suzuki, Masakazu Ichinose

    THORAX　72　(10)　893-904　2017/10

    DOI： 10.1136/thoraxjnl-2016-209352 　

    ISSN： 0040-6376

    eISSN： 1468-3296

  54. Effects of protease-treated royal jelly on muscle strength in elderly nursing home residents: A randomized, double-blind, placebo-controlled, dose-response study Peer-reviewed

    Ge Meng, Honglei Wang, Yinghua Pei, Yanmei Li, Hongmei Wu, Yanqi Song, Qi Guo, Hui Guo, Shinobu Fukushima, Tomoki Tatefuji, Jiazhong Wang, Huanmin Du, Qian Su, Wen Zhang, Suxing Shen, Xiuyang Wang, Renwei Dong, Peipei Han, Tatsuma Okazaki, Ryoichi Nagatomi, Jianhua Wang, Guowei Huang, Zhong Sun, Kun Song, Kaijun Niu

    SCIENTIFIC REPORTS　7　(1)　11416　2017/09

    DOI： 10.1038/s41598-017-11415-6 　

    ISSN： 2045-2322

  55. Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer Peer-reviewed

    Naoki Tode, Toshiaki Kikuchi, Tomohiro Sakakibara, Taizou Hirano, Akira Inoue, Shinya Ohkouchi, Tsutomu Tamada, Tatsuma Okazaki, Akira Koarai, Hisatoshi Sugiura, Tetsuya Niihori, Yoko Aoki, Keiko Nakayama, Kunio Matsumoto, Yoichi Matsubara, Masayuki Yamamoto, Akira Watanabe, Toshihiro Nukiwa, Masakazu Ichinose

    CANCER SCIENCE　108　(6)　1263-1270　2017/06

    DOI： 10.1111/cas.13233 　

    ISSN： 1349-7006

  56. Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer. International-journal Peer-reviewed

    Naoki Tode, Toshiaki Kikuchi, Tomohiro Sakakibara, Taizou Hirano, Akira Inoue, Shinya Ohkouchi, Tsutomu Tamada, Tatsuma Okazaki, Akira Koarai, Hisatoshi Sugiura, Tetsuya Niihori, Yoko Aoki, Keiko Nakayama, Kunio Matsumoto, Yoichi Matsubara, Masayuki Yamamoto, Akira Watanabe, Toshihiro Nukiwa, Masakazu Ichinose

    Cancer science　108　(6)　1263-1270　2017/06

    DOI： 10.1111/cas.13233 　

    ISSN： 1347-9032

    More details Close

    Lung cancer accompanied by somatic activating mutations in the epidermal growth factor receptor (EGFR) gene, which is associated with a significant clinical response to the targeted therapy, is frequently found in never-smoking Asian women with adenocarcinoma. Although this implies genetic factors underlying the carcinogenesis, the etiology remains unclear. To gain insight into the pathogenic mechanisms, we sequenced the exomes in the peripheral-blood DNA from six siblings, four affected and two unaffected siblings, of a family with familial EGFR-mutant lung adenocarcinoma. We identified a heterozygous missense mutation in MET proto-oncogene, p.Asn375Lys, in all four affected siblings. Combined with somatic loss of heterozygosity for MET, the higher allele frequency in a Japanese sequencing database supports a causative role of the MET mutation in EGFR-mutant lung cancer. Functional assays showed that the mutation reduces the binding affinity of MET for its ligand, hepatocyte growth factor, and damages the subsequent cellular processes, including proliferation, clonogenicity, motility and tumorigenicity. The MET mutation was further observed to abrogate the ERBB3-mediated AKT signal transduction, which is shared downstream by EGFR. These findings provide an etiological view that the MET mutation is involved in the pathogenesis of EGFR-mutant lung cancer because it generates oncogenic stress that induces compensatory EGFR activation. The identification of MET in a family with familial EGFR-mutant lung cancer is insightful to explore the pathogenic mechanism of not only familial, but also sporadic EGFR-mutant lung cancer by underscoring MET-related signaling molecules.

  57. [A Case of Pneumomycosis with Paraplegia]. Peer-reviewed

    Sato K, Yamada M, Hirano T, Mitsuhashi Y, Okazaki T, Tamada T, Sugiura H, Ichinose M

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　106　(3)　591-597　2017/03

    ISSN： 0021-5384

  58. 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells Peer-reviewed

    Yuichiro Hashimoto, Hisatoshi Sugiura, Shinsaku Togo, Akira Koarai, Kyoko Abe, Mitsuhiro Yamada, Tomohiro Ichikawa, Takashi Kikuchi, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY　310　(11)　L1028-L1041　2016/06

    DOI： 10.1152/ajplung.00351.2015 　

    ISSN： 1040-0605

    eISSN： 1522-1504

  59. Dysphagia, dystussia, and aspiration pneumonia in elderly people Peer-reviewed

    Satoru Ebihara, Hideki Sekiya, Midori Miyagi, Takae Ebihara, Tatsuma Okazaki

    JOURNAL OF THORACIC DISEASE　8　(3)　632-639　2016/03

    DOI： 10.21037/jtd.2016.02.60 　

    ISSN： 2072-1439

    eISSN： 2077-6624

  60. Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy Peer-reviewed

    Tadahisa Numakura, Tsutomu Tamada, Masayuki Nara, Soshi Muramatsu, Koji Murakami, Toshiaki Kikuchi, Makoto Kobayashi, Miho Muroi, Tatsuma Okazaki, Sho Takagi, Yoshinobu Eishi, Masakazu Ichinose

    BMC PULMONARY MEDICINE　16　30　2016/02

    DOI： 10.1186/s12890-016-0193-5 　

    ISSN： 1471-2466

  61. Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease Peer-reviewed

    Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose

    Respiratory Research　17　(1)　7　2016/01/20

    DOI： 10.1186/s12931-016-0322-y 　

    ISSN： 1465-9921

    eISSN： 1465-993X

  62. Possible role of Kruppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease Peer-reviewed

    Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose

    RESPIRATORY RESEARCH　17　2016/01

    DOI： 10.1186/s12931-016-0322-y 　

    ISSN： 1465-993X

    eISSN： 1465-9921

  63. Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia Peer-reviewed

    Mayumi Nihei, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Kaijun Niu, Peijun Gui, Tokiwa Tamai, Toshihiro Nukiwa, Mutsuo Yamaya, Toshiaki Kikuchi, Ryoichi Nagatomi, Takae Ebihara, Masakazu Ichinose

    JOURNAL OF PATHOLOGY　235　(4)　632-645　2015/03

    DOI： 10.1002/path.4473 　

    ISSN： 0022-3417

    eISSN： 1096-9896

  64. Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2 Peer-reviewed

    Kamalika Mojumdar, Feng Liang, Christian Giordano, Christian Lemaire, Gawiyou Danialou, Tatsuma Okazaki, Johanne Bourdon, Moutih Rafei, Jacques Galipeau, Maziar Divangahi, Basil J. Petrof

    EMBO MOLECULAR MEDICINE　6　(11)　1476-1492　2014/11

    DOI： 10.15252/emmm.201403967 　

    ISSN： 1757-4676

    eISSN： 1757-4684

  65. Muscle-Specific Inhibition of the Classical Nuclear Factor-kappa B Pathway Is Protective Against Diaphragmatic Weakness in Murine Endotoxemia Peer-reviewed

    Tatsuma Okazaki, Feng Liang, Tong Li, Christian Lemaire, Gawiyou Danialou, Steven E. Shoelson, Basil J. Petrof

    CRITICAL CARE MEDICINE　42　(7)　E501-E509　2014/07

    DOI： 10.1097/CCM.0000000000000407 　

    ISSN： 0090-3493

    eISSN： 1530-0293

  66. Coffee treatment prevents the progression of sarcopenia in aged mice in vivo and in vitro Peer-reviewed

    Yinting Guo, Kaijun Niu, Tatsuma Okazaki, Hongmei Wu, Takeo Yoshikawa, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose, Kazuhiko Yanai, Hiroyuki Arai, Guowei Huang, Ryoichi Nagatomi

    EXPERIMENTAL GERONTOLOGY　50　1-8　2014/02

    DOI： 10.1016/j.exger.2013.11.005 　

    ISSN： 0531-5565

    eISSN： 1873-6815

  67. Chronic Inflammation And Exaggerated Lymphangiogenesis In A Mouse Model And Human Patients Of Aspiration Pneumonia

    M. Kobayashi, T. Okazaki, M. Nihei, S. Ebihara, K. Niu, P. Gui, T. Nukiwa, M. Yamaya, R. Nagatomi, T. Ebihara, M. Ichinose

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　189　2014

    ISSN： 1073-449X

    eISSN： 1535-4970

  68. Royal Jelly Prevents the Progression of Sarcopenia in Aged Mice In Vivo and In Vitro Peer-reviewed

    Kaijun Niu, Hui Guo, Yinting Guo, Satoru Ebihara, Masanori Asada, Takashi Ohrui, Katsutoshi Furukawa, Masakazu Ichinose, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai, Tatsuma Okazaki, Ryoichi Nagatomi

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES　68　(12)　1482-1492　2013/12

    DOI： 10.1093/gerona/glt041 　

    ISSN： 1079-5006

    eISSN： 1758-535X

  69. Exaggerated Lymphangiogensis And Remodeled Blood Vessels In A Newly Developed Mouse Model Of Aspiration Pneumonia

    M. Kobayashi, T. Okazaki, M. Nihei, T. Kikuchi, K. Niu, R. Nagatomi, S. Ebihara, M. Ichinose

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　187　2013

    ISSN： 1073-449X

    eISSN： 1535-4970

  70. EGFR遺伝子変異を伴う家族性肺腺癌患者におけるエクソーム解析(Whole-exome sequencing of familial non-small cell lung cancer patients with the EGFR gene mutations)

    東出 直樹, 菊地 利明, 榊原 智博, 福原 達朗, 大河内 眞也, 岡崎 達馬, 井上 彰, 貫和 敏博

    日本癌学会総会記事　71回　545-546　2012/08

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  71. Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth Peer-reviewed

    Kaijun Niu, Masanori Asada, Tatsuma Okazaki, Shinsuke Yamanda, Takae Ebihara, Hui Guo, Dongying Zhang, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, Satoru Ebihara

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY　46　(4)　515-523　2012/04

    DOI： 10.1165/rcmb.2011-0068OC 　

    ISSN： 1044-1549

  72. Impact of physical activity and performance on medical care costs among the Japanese elderly Peer-reviewed

    Guang Yang, Kaijun Niu, Kazuki Fujita, Atsushi Hozawa, Kaori Ohmori-Matsuda, Shinichi Kuriyama, Naoki Nakaya, Satoru Ebihara, Tatsuma Okazaki, Hiu Guo, Chihaya Miura, Hideko Takahashi, Hiroyuki Arai, Ichiro Tsuji, Ryoichi Nagatomi

    GERIATRICS & GERONTOLOGY INTERNATIONAL　11　(2)　157-165　2011/04

    DOI： 10.1111/j.1447-0594.2010.00651.x 　

    ISSN： 1444-1586

  73. Capillary Defects and Exaggerated Inflammatory Response in the Airways of EphA2-Deficient Mice Peer-reviewed

    Tatsuma Okazaki, Amy Ni, Peter Baluk, Oluwasheyi A. Ayei, Jennifer Kearley, Anthony J. Coyle, Alison Humbles, Donald M. McDonald

    AMERICAN JOURNAL OF PATHOLOGY　174　(6)　2388-2399　2009/06

    DOI： 10.2353/ajpath.2009.080949 　

    ISSN： 0002-9440

  74. alpha 5 beta 1 Integrin Blockade Inhibits Lymphangiogenesis in Airway Inflammation Peer-reviewed

    Tatsuma Okazaki, Amy Ni, Oluwasheyi A. Ayeni, Peter Baluk, Li-Chin Yao, Doerle Vossmeyer, Gunther Zischinsky, Grit Zahn, Jochen Knolle, Claudia Christner, Donald M. McDonald

    AMERICAN JOURNAL OF PATHOLOGY　174　(6)　2378-2387　2009/06

    DOI： 10.2353/ajpath.2009.080942 　

    ISSN： 0002-9440

  75. 固形腫瘍に対するエリスロポエチン製剤の効果 Invited Peer-reviewed

    海老原覚, 岡崎達馬, 浅田成紀, 矢満田慎介, 海老原孝枝, 荒井啓行

    日本呼吸器学会雑誌　47　(増刊)　206-206　2009/05

    Publisher:

    ISSN： 1343-3490

  76. Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade Peer-reviewed

    Shinsuke Yamanda, Satoru Ebihara, Masanori Asada, Tatsuma Okazaki, Kaijun Niu, Takae Ebihara, Akemi Koyanagi, Noriko Yamaguchi, Hideo Yagita, Hiroyuki Arai

    BLOOD　113　(15)　3631-3639　2009/04

    DOI： 10.1182/blood-2008-07-170381 　

    ISSN： 0006-4971

    eISSN： 1528-0020

  77. Depletion of Serotonin and Selective Inhibition of 2B Receptor Suppressed Tumor Angiogenesis by Inhibiting Endothelial Nitric Oxide Synthase and Extracellular Signal-Regulated Kinase 1/2 Phosphorylation Peer-reviewed

    Masanori Asada, Satoru Ebihara, Shinsuke Yamanda, Kaijun Niu, Tatsuma Okazaki, Ichiro Sora, Hiroyuki Arai

    NEOPLASIA　11　(4)　408-U117　2009/04

    DOI： 10.1593/neo.81630 　

    ISSN： 1522-8002

  78. Erythropoietin promotes the growth of tumors lacking its receptor and decreases survival of tumor-bearing mice by enhancing angiogenesis. International-journal Peer-reviewed

    Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Kaijun Niu, Hiroyuki Arai

    Neoplasia (New York, N.Y.)　10　(9)　932-9　2008/09

    DOI： 10.1593/neo.08140 　

    ISSN： 1522-8002

    eISSN： 1476-5586

    More details Close

    Erythropoietin (Epo), a known hematopoietic growth factor, has been reported to promote tumor growth and angiogenesis in Epo receptor (EpoR)-positive tumors, but its effects on EpoR-negative tumors have not been clearly shown. Here, we show that Epo accelerates the growth of EpoR-negative tumors by promoting tumor angiogenesis. Mice were inoculated with Lewis lung carcinoma cells and treated with Epo. Erythropoietin accelerated tumor growth and increased intratumoral microvessel density, although it did not accelerate Lewis lung carcinoma cell tumor proliferation in vitro. To observe the direct effect of Epo on endothelial cells, we examined human dermal microvascular endothelial cells (HMVECs) that expressed EpoR. Erythropoietin induced the proliferation of HMVECs and protected them from H2O2-induced cell death. Erythropoietin activated the extracellular signal-regulated kinase signaling pathway and up-regulated the expression of the downstream antiapoptotic protein Bcl-xL in HMVECs. Moreover, in both the absence and presence of tumors, in vivo treatment of mice with Epo increased circulating endothelial progenitor cells. To investigate the role of Epo in a primary tumor model, we inoculated the chemical carcinogen methylcholanthrene (MCA) subcutaneously into mice at two doses, a high or a low dose, which induced fibrosarcoma, and treated them with Epo. Erythropoietin promoted tumor growth after MCA inoculation at both doses and decreased the overall survival of the mice inoculated with the high-dose MCA. However, Epo did not increase the incidence of fibrosarcoma at either dose. Lewis lung carcinoma cells and MCA-induced fibrosarcomas did not express EpoR. These results suggest that Epo accelerates the growth of tumors that lack EpoR expression by promoting tumor angiogenesis.

  79. Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter Peer-reviewed

    Masanori Asada, Satoru Ebihara, Yohtaro Numachi, Tatsuma Okazaki, Shinsuke Yamanda, Kazutaka Ikeda, Hiroyasu Yasuda, Ichiro Sora, Hiroyuki Arai

    INTERNATIONAL JOURNAL OF CANCER　123　(3)　511-518　2008/08

    DOI： 10.1002/ijc.23562 　

    ISSN： 0020-7136

    eISSN： 1097-0215

  80. 固形腫瘍に対するM-CSF製剤の効果とその機序 (日本呼吸器学会雑誌)

    海老原覚, 岡崎達馬, 浅田成紀, 矢満田慎介, 山崎都, 大類孝, 山谷睦雄

    日本呼吸器学会雑誌　46　(増刊)　326-326　2008

  81. Delta-like 4阻害剤によるマウス肺扁平上皮癌に対する分子標的治療 (日本呼吸器学会雑誌)

    矢満田慎介, 浅田成紀, 牛凱軍, 岡崎達馬, 浅村孝昭, 山崎都, 山口典子, 八木田秀雄, 海老原覚, 山谷睦雄

    日本呼吸器学会雑誌　46　(増刊)　326-326　2008

  82. Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes Peer-reviewed

    Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Yamanda, Yoshifumi Saijo, Yasuyuki Shiraishi, Takae Ebihara, Kaijun Niu, He Mei, Hiroyuki Arai, Tomoyuki Yambe

    AMERICAN JOURNAL OF PATHOLOGY　171　(4)　1093-1103　2007/10

    DOI： 10.2353/ajpath.2007.061191 　

    ISSN： 0002-9440

  83. Paralytic ileus after discontinuation of cholinesterase inhibitor Peer-reviewed

    Tatsuma Okazaki, Katsutoshi Furukawa, Hiroshi Kubo, Miho Tsutsui, Emi Furukawa, Masanori Asada, Mutsuo Yamaya, Takashi Seki, Koh Iwaski, Hiroyuki Arai

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　54　(10)　1620-1621　2006/10

    DOI： 10.1111/j.1532-5415.2006.00896.x 　

    ISSN： 0002-8614

    eISSN： 1532-5415

  84. Effects of menthol on the triggering of the swallowing reflex in elderly patients with dysphagia Peer-reviewed

    Takae Ebihara, Satoru Ebihara, Aya Watando, Tatsuma Okazaki, Masanori Asada, Takashi Ohrui, Mutsuo Yamaya, Hiroyuki Arai

    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY　62　(3)　369-371　2006/09

    DOI： 10.1111/j.1365-2125.2006.02666.x 　

    ISSN： 0306-5251

  85. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer Peer-reviewed

    H Yasuda, M Yamaya, K Nakayama, T Sasaki, S Ebihara, A Kanda, M Asada, D Inoue, T Suzuki, T Okazaki, H Takahashi, M Yoshida, T Kaneta, K Ishizawa, S Yamanda, N Tomita, M Yamasaki, A Kikuchi, H Kubo, H Sasaki

    JOURNAL OF CLINICAL ONCOLOGY　24　(4)　688-694　2006/02

    DOI： 10.1200/JCO.2005.04.0436 　

    ISSN： 0732-183X

  86. Macrophage Colony Stimulating Factor (M-CSF)による骨格筋の細胞死抑制作用 (日本老年医学会雑誌)

    矢満田慎介, 岡崎達馬, 海老原覚, 大類孝, 山谷睦雄

    日本老年医学会雑誌　43　(Suppl.)　140-140　2006

  87. 健常高齢ex-smokerにおける咳反射の検討 (日本老年医学会雑誌)

    海老原覚, 海老原孝枝, 岡崎達馬, 大類孝, 山谷睦雄

    日本老年医学会雑誌　43　(Suppl.)　131-131　2006

    Publisher:

    ISSN： 0300-9173

  88. 化学放射線療法後に軽度放射線肺臓炎を発症した肺癌患者における予後に関する研究 (日本呼吸器学会雑誌)

    吉田元樹, 安田浩康, 中山勝敏, 神田暁郎, 佐々木陽彦, 海老原覚, 浅田成紀, 鈴木朋子, 岡崎達馬, 山崎都, 矢満田慎介, 山谷睦雄

    日本呼吸器学会雑誌　44　(増刊)　265-265　2006

  89. Granulocyte colony-stimulating factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1+CD11b+cells in cancer animal models Peer-reviewed

    T Okazaki, S Ebihara, M Asada, A Kanda, H Sasaki, M Yamaya

    INTERNATIONAL IMMUNOLOGY　18　(1)　1-9　2006/01

    DOI： 10.1093/intimm/dxh334 　

    ISSN： 0953-8178

  90. A comparison of the effects of unfractionated heparin, dalteparin and danaparoid on vascular endothelial growth factor-induced tumour angiogenesis and heparanase activity Peer-reviewed

    H Takahashi, S Ebihara, T Okazaki, M Asada, H Sasaki, M Yamaya

    BRITISH JOURNAL OF PHARMACOLOGY　146　(3)　333-343　2005/10

    DOI： 10.1038/sj.bjp.0706344 　

    ISSN： 0007-1188

  91. Macrophage colony-stimulating factor induces vascular endothelial growth factor production in skeletal muscle and promotes tumor angiogenesis Peer-reviewed

    T Okazaki, S Ebihara, H Takahashi, M Asada, A Kanda, H Sasaki

    JOURNAL OF IMMUNOLOGY　174　(12)　7531-7538　2005/06

    DOI： 10.4049/jimmunol.174.12.7531 　

    ISSN： 0022-1767

  92. Capsaicin troche for swallowing dysfunction in older people Peer-reviewed

    T Ebihara, H Takahashi, S Ebihara, T Okazaki, T Sasaki, A Watando, M Nemoto, H Sasaki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　53　(5)　824-828　2005/05

    DOI： 10.1111/j.1532-5415.2005.53261.x 　

    ISSN： 0002-8614

  93. Tiapride may accelerate lung cancer in older people: a case report Peer-reviewed

    M Asada, S Ebihara, T Okazaki, H Takahashi, H Yasuda, H Sasaki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　53　(4)　731-732　2005/04

    DOI： 10.1111/j.1532-5415.2005.53228_4.x 　

    ISSN： 0002-8614

  94. Cigarette smoking, cough reflex, and respiratory tract infection Peer-reviewed

    S Ebihara, T Ebihara, T Okazaki, H Sasaki

    ARCHIVES OF INTERNAL MEDICINE　165　(7)　814-814　2005/04

    DOI： 10.1001/archinte.165.7.814-a 　

    ISSN： 0003-9926

  95. 高齢者誤嚥性肺炎リスクファクターに対するカプサイシントローチの効果 (日本呼吸器学会雑誌)

    海老原孝枝, 海老原覚, 高橋秀徳, 岡崎達馬, 佐々木英忠

    日本呼吸器学会雑誌　43　(増刊)　227-227　2005

    Publisher:

    ISSN： 1343-3490

  96. BCG接種後の皮膚結核をMultiplex PCR法により同定しえた一例 (日本呼吸器学会雑誌)

    岡崎達馬, 海老原覚, 高橋秀徳, 浅田成紀, 佐々木英忠

    日本呼吸器学会雑誌　43　(増刊)　207-207　2005

  97. 高齢施設入所者におけるテオフィリンの嚥下反射に対する影響 (日本呼吸器学会雑誌)

    海老原覚, 海老原孝枝, 岡崎達馬, 佐々木英忠

    日本呼吸器学会雑誌　43　(増刊)　173-173　2005

    Publisher:

    ISSN： 1343-3490

  98. 高齢者誤嚥性肺炎リスクファクターに対するカプサイシントローチの効果 (日本老年医学会雑誌)

    海老原孝枝, 高橋秀徳, 海老原覚, 渡戸亜矢, 岡崎達馬, 佐々木陽彦, 根本都, 山谷睦雄, 荒井啓行, 佐々木英忠

    日本老年医学会雑誌　42　(Suppl.)　58-58　2005

    Publisher:

    ISSN： 0300-9173

  99. Multiplex PCR-identified cutaneous tuberculosis evoked by Mycobacterium bovis BGG vaccination in a healthy baby Peer-reviewed

    T Okazaki, S Ebihara, H Takahashi, M Asada, A Sato, M Seki, H Ohto, H Sasaki

    JOURNAL OF CLINICAL MICROBIOLOGY　43　(1)　523-525　2005/01

    DOI： 10.1128/JCM.43.1.523-525.2005 　

    ISSN： 0095-1137

  100. Effect of temperature on swallowing reflex in elderly patients with aspiration pneumonia Peer-reviewed

    A Watando, S Ebihara, T Ebihara, T Okazaki, H Takahashi, M Asada, H Sasaki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　52　(12)　2143-2144　2004/12

    DOI： 10.1111/j.1532-5415.2004.52579_3.x 　

    ISSN： 0002-8614

  101. Theophylline-improved swallowing reflex in elderly nursing home patients Peer-reviewed

    T Ebihara, S Ebihara, T Okazaki, H Takahashi, A Watando, H Yasuda, H Sasaki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　52　(10)　1787-1788　2004/10

    DOI： 10.1111/j.1532-5415.2004.52479_10.x 　

    ISSN： 0002-8614

  102. Daily oral care and cough reflex sensitivity in elderly nursing home patients Peer-reviewed

    A Watando, S Ebihara, T Ebihara, T Okazaki, H Takahashi, M Asada, H Sasaki

    CHEST　126　(4)　1066-1070　2004/10

    DOI： 10.1378/chest.126.4.1066 　

    ISSN： 0012-3692

  103. Clinical significance of heparanase activity in primary resected non-small cell lung cancer Peer-reviewed

    H Takahashi, S Ebihara, T Okazaki, S Suzuki, M Asada, H Kubo, H Sasaki

    LUNG CANCER　45　(2)　207-214　2004/08

    DOI： 10.1016/j.lungcan.2004.02.007 　

    ISSN： 0169-5002

  104. Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS Peer-reviewed

    T Sasazuki, T Okazaki, K Tada, S Sakon-Komazawa, M Katano, M Tanaka, H Yagita, K Okumura, N Tominaga, Y Hayashizaki, Y Okazaki, H Nakano

    MOLECULAR IMMUNOLOGY　41　(5)　547-551　2004/07

    DOI： 10.1016/j.molimm.2004.03.030 　

    ISSN： 0161-5890

  105. Loxoprofen sodium and survival in older people with advanced non-small cell lung cancer Peer-reviewed

    A Kanda, S Ebihara, T Okazaki, H Yasuda, H Sasaki

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY　52　(3)　471-472　2004/03

    DOI： 10.1111/j.1532-5415.2004.52125_6.x 　

    ISSN： 0002-8614

  106. Significance of three-dimensional computed tomography in a very old patient with sigmoid volvulus

    Ebihara Satoru, Okazaki Tatsuma, Takahashi Hidenori, Kanda Akio, Tsuboi Masahiro, Sasaki Hidetada

    Geriatrics and Gerontolofy International　4　(3)　181-183　2004

  107. 喀痰喀出困難高齢患者に対するmechanical insufflation-exsufflation(MI-E)とフラッターの組み合わせの効果 (日本老年医学会雑誌)

    佐々木陽彦, 海老原覚, 山谷睦雄, 岡崎達馬, 神田暁郎, 根本都, 渡戸亜矢, 佐々木英忠

    日本老年医学会雑誌　41　(Suppl.)　163-163　2004

  108. マクロファージコロニー刺激因子は末梢血中の血管内皮前駆細胞を増加させ血管新生を促進する (炎症・再生)

    岡崎達馬, 海老原覚, 高橋秀徳, 浅田成紀, 神田暁郎, 佐々木秀忠

    炎症・再生　24　(4)　513-513　2004

  109. BCG接種後,他の部位に結核性皮下膿瘍をきたした1例 (結核)

    岡崎達馬, 海老原覚, 高橋秀徳, 浅田成紀, 山谷睦雄, 佐々木英忠, 大戸秀恭, 佐藤明正, 関昌明

    結核　79　(4)　321-321　2004

  110. 施設入所高齢者における口腔ケアによる咳反射の改善 (日本老年医学会雑誌)

    海老原覚, 海老原孝枝, 中條瑞枝, 渡戸亜矢, 岡崎達馬, 高橋秀徳, 佐々木英忠

    日本老年医学会雑誌　41　(Suppl.)　137-137　2004

    Publisher:

    ISSN： 0300-9173

  111. Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappa B p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway Peer-reviewed

    H Sakurai, S Suzuki, N Kawasaki, H Nakano, T Okazaki, A Chino, T Doi, Saiki, I

    JOURNAL OF BIOLOGICAL CHEMISTRY　278　(38)　36916-36923　2003/09

    DOI： 10.1074/jbc.M301598200 　

    ISSN： 0021-9258

  112. NF-kappa B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death Peer-reviewed

    S Sakon, Xue, X, M Takekawa, T Sasazuki, T Okazaki, Y Kojima, JH Piao, H Yagita, K Okumura, T Doi, H Nakano

    EMBO JOURNAL　22　(15)　3898-3909　2003/08

    DOI： 10.1093/emboj/cdg379 　

    ISSN： 0261-4189

  113. 健常人における塩酸ドキサプラム投与の吸気抵抗負荷時呼吸困難感に及ぼす影響

    海老原覚, 海老原孝枝, 神田暁郎, 高橋秀徳, 岡崎達馬, 安田浩康, 佐々木陽彦, 佐々木英忠

    日本呼吸器学会雑誌　41　(増刊)　119-119　2003

    Publisher:

    ISSN： 1343-3490

  114. ロキソプロフェンによる腫瘍制御 (日本老年医学会雑誌)

    神田暁郎, 海老原覚, 高橋秀徳, 岡崎達馬, 安田浩康, 山谷睦雄, 佐々木英忠

    日本老年医学会雑誌　40　(Suppl.)　118-118　2003

  115. 非小細胞肺癌におけるHeparan degrading enzyme(Heparanase)活性とその病理学的因子及び予後との関連の検討

    高橋秀徳, 海老原覚, 神田暁郎, 岡崎達馬, 久保裕司, 山田充啓, 鈴木聡, 佐々木英忠

    日本呼吸器学会雑誌　41　(増刊)　142-142　2003

    Publisher:

    ISSN： 1343-3490

  116. エンドトキシンによるマウス肺におけるVEGF receptor 2の変化

    神田暁郎, 海老原覚, 岡崎達馬, 佐々木英忠

    日本呼吸器学会雑誌　41　(増刊)　123-123　2003

  117. Phosphorylation of serine 276 is essential for p65 NF-kappa B subunit-dependent cellular responses Peer-reviewed

    T Okazaki, S Sakon, T Sasazuki, H Sakurai, T Doi, H Yagita, K Okumura, H Nakano

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　300　(4)　807-812　2003/01

    DOI： 10.1016/S0006-291X(02)02932-7 　

    ISSN： 0006-291X

  118. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death Peer-reviewed

    T Sasazuki, T Sawada, S Sakon, T Kitamura, T Kishi, T Okazaki, M Katano, M Tanaka, M Watanabe, H Yagita, K Okumura, H Nakano

    JOURNAL OF BIOLOGICAL CHEMISTRY　277　(32)　28853-28860　2002/08

    DOI： 10.1074/jbc.M203190200 　

    ISSN： 0021-9258

  119. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death Peer-reviewed

    K Tada, T Okazaki, S Sakon, T Kobarai, K Kurosawa, S Yamaoka, H Hashimoto, TW Mak, H Yagita, K Okumura, WC Yeh, H Nakano

    JOURNAL OF BIOLOGICAL CHEMISTRY　276　(39)　36530-36534　2001/09

    ISSN： 0021-9258

  120. Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice Peer-reviewed

    T Okazaki, A Nakao, H Nakano, F Takahashi, K Takahashi, O Shimozato, K Takeda, H Yagita, K Okumura

    JOURNAL OF IMMUNOLOGY　167　(4)　1977-1981　2001/08

    ISSN： 0022-1767

  121. Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis Peer-reviewed

    F Takahashi, K Takahashi, T Okazaki, K Maeda, H Ienaga, M Maeda, S Kon, T Uede, Y Fukuchi

    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY　24　(3)　264-271　2001/03

    ISSN： 1044-1549

  122. 16.当院における小児熱傷症例の検討(第59回日本小児外科学会東北地方会)

    岡崎 達馬, 澤 直哉, 三浦 一章, 岡本 道孝, 高橋 秀禎, 今野 文博, 小柳 雅是, 井上 国彦, 堀 義生, 佐々木 英之, 千葉 和史, 二瓶 義博, 平宇 健治, 平野 孝幸

    日本小児外科学会雑誌　33　(4)　790-790　1997

    Publisher: 特定非営利活動法人 日本小児外科学会

    DOI： 10.11164/jjsps.33.4_790_2 　

Show all ︎Show first 5

Misc. 123

  1. 両上肢単関節HALを用いた遠位型ミオパチーに対するリハビリテーション治療

    鈴木 直輝, 大屋 博充, 井泉 瑠美子, 池田 謙輔, 岡崎 達馬, 青木 正志, 海老原 覚

    日本難病医療ネットワーク学会機関誌　13　(1)　133-133　2025/11

    Publisher: (一社)日本難病医療ネットワーク学会

    ISSN： 2188-1006

  2. 両上肢単関節HALを用いた遠位型ミオパチーに対するリハビリテーション治療

    鈴木 直輝, 大屋 博充, 井泉 瑠美子, 池田 謙輔, 岡崎 達馬, 青木 正志, 海老原 覚

    日本難病看護学会誌　30　(2)　133-133　2025/10

    Publisher: (一社)日本難病看護学会

    ISSN： 1343-1692

  3. 地域在住高齢者の総コレステロール値と死因別死亡の関連 鶴ヶ谷プロジェクト

    兪 睿, 岡崎 達馬, 宮城 翠, 鈴木 直輝, 海老原 覚

    日本老年医学会雑誌　62　(4)　446-446　2025/10

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  4. 遠位型ミオパチーに対する両上肢装着型サイボーグを用いたリハビリテーション治療

    鈴木直輝, 古澤義人, 宮城翠, 三浦平寛, 高橋珠緒, 岡崎達馬, 海老原覚

    Japanese Journal of Rehabilitation Medicine (Web)　62　(Supplement)　2025

    ISSN： 1881-8560

  5. ヨガの咳嗽に与える影響の検討 ランダム化クロスオーバー研究

    三浦久子, 岡崎達馬, 三浦平寛, 宮城翠, 海老原覚

    日本咳嗽学会学術大会プログラム・抄録集　26th　2024

  6. 労作時呼吸困難の原因検索にCPXが役立った間質性肺炎の1例

    三浦平寛, 中澤ちひろ, 古澤義人, 宮城翠, 高橋珠緒, 岡崎達馬, 海老原覚

    Japanese Journal of Rehabilitation Medicine (Web)　61　(Autumn)　2024

    ISSN： 1881-8560

  7. [Secondary Publication] 本邦の嚥下障害患者における,咽喉頭感覚評価法に関するアンケート調査

    神林 友紀, 加藤 健吾, 池田 怜吉, 鈴木 淳, 本藏 陽平, 平野 愛, 太田 淳, 加賀谷 斉, 井上 誠, 兵頭 政光, 大森 孝一, 末廣 篤, 岡崎 達馬, 出江 紳一, 小山 重人, 佐々木 啓一, 熊井 良彦, 二藤 隆春, 栗山 進一, 小川 武則, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　126　(3)　243-244　2023/03

    Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN： 2436-5793

    eISSN： 2436-5866

  8. 【摂食嚥下障害に対するリハビリテーション医学・医療The Cutting Edge】慢性肺疾患と摂食嚥下障害

    岡崎 達馬, 出江 紳一, 海老原 覚

    The Japanese Journal of Rehabilitation Medicine　59　(9)　884-887　2022/09

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  9. 【咀嚼と嚥下と誤嚥性肺炎】咀嚼、嚥下、誤嚥性肺炎に関わる基礎知識 フレイル、サルコペニアと嚥下障害、誤嚥性肺炎

    岡崎 達馬, 出江 紳一

    JOHNS　38　(5)　500-502　2022/05

    Publisher: (株)東京医学社

    ISSN： 0910-6820

  10. 嚥下性肺炎の重症化予防における、転写因子Nrf2の機能の解析

    橋本 光, 岡崎 達馬, 本蔵 陽平, 香取 幸夫

    日本耳鼻咽喉科頭頸部外科学会会報　125　(4)　725-725　2022/04

    Publisher: (一社)日本耳鼻咽喉科頭頸部外科学会

    ISSN： 2436-5793

    eISSN： 2436-5866

  11. 高齢者肺炎のサルコペニアとリハビリテーション医療

    岡崎達馬, 出江紳一

    Japanese Journal of Rehabilitation Medicine　58　(Autumn)　S236-S236　2021

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  12. 誤嚥性肺炎とサルコペニア

    岡崎達馬, 鈴鴨よしみ, 宮武ミドリ, 出江紳一, 出江紳一, 出江紳一

    Japanese Journal of Rehabilitation Medicine　58　(Supplement)　2021

    ISSN： 1881-3526

  13. 高齢者診療Up To Date No.7)サルコペニアとフレイル診療

    岡崎達馬, 出江紳一, 出江紳一

    新薬と臨床　70　(12)　2021

    ISSN： 0559-8672

  14. New development in pulmonary rehabilitation Aspiration pneumonia

    岡崎達馬, 出江紳一, 出江紳一

    総合リハビリテーション　49　(11)　2021

    ISSN： 0386-9822

  15. 炎症とサルコペニア 高齢者肺炎との関係を中心に

    岡崎 達馬

    リハビリテーション栄養　4　(2)　226-226　2020/10

    Publisher: (一社)日本リハビリテーション栄養学会

  16. 【ポリファーマシー対策の実践法】嚥下障害におけるポリファーマシー対策

    岡崎 達馬, 出江 紳一

    老年内科　1　(2)　155-159　2020/02

    Publisher: (有)科学評論社

    ISSN： 2435-1881

  17. 誤嚥性肺炎発症へのサルコペニアの関与

    岡崎 達馬, 海老原 孝枝, 永井 久美子, 庄司 真美, 小松 理世, 二瓶 真由美, 八重柏 政宏, 出江 紳一

    日本老年医学会雑誌　56　(Suppl.)　137-137　2019/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  18. 誤嚥性肺炎発症へのサルコペニアの関与

    岡崎 達馬, 海老原 孝枝, 出江 紳一

    The Japanese Journal of Rehabilitation Medicine　56　(特別号)　2-6　2019/05

    Publisher: (公社)日本リハビリテーション医学会

    ISSN： 1881-3526

    eISSN： 1881-8560

  19. 【外来における嚥下のみかた】外来で行う摂食嚥下指導・訓練 嚥下障害症例における呼吸機能訓練の役割

    岡崎 達馬, 黒澤 一, 出江 伸一

    JOHNS　35　(3)　365-367　2019/03

    Publisher: (株)東京医学社

    ISSN： 0910-6820

  20. サルコペニアの科学と臨床 呼吸器疾患とサルコペニア・フレイル

    海老原 覚, 岡崎 達馬

    日本内科学会雑誌　107　(9)　1708-1712　2018/09

    Publisher: (一社)日本内科学会

    ISSN： 0021-5384

    eISSN： 1883-2083

  21. EGFR遺伝子変異陽性肺腺癌においてAXLキナーゼは免疫抑制分子を促進する(Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas)

    突田 容子, 宮内 栄作, 齊藤 涼子, 岡崎 達馬, 井上 彰, 岡田 克典, 一ノ瀬 正和

    日本癌学会総会記事　77回　1885-1885　2018/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  22. EGFR遺伝子変異陽性肺腺癌においてAXLキナーゼは免疫抑制分子を促進する(Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas)

    突田 容子, 宮内 栄作, 齊藤 涼子, 岡崎 達馬, 井上 彰, 岡田 克典, 一ノ瀬 正和

    日本癌学会総会記事　77回　1885-1885　2018/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  23. 基礎研究がリハビリテーション医療を変える 誤嚥性肺炎の基礎研究

    海老原 覚, 岡崎 達馬

    Journal of Clinical Rehabilitation　27　(9)　892-896　2018/08

    Publisher: 医歯薬出版(株)

    ISSN： 0918-5259

  24. 基礎研究がリハビリテーション医療を変える 誤嚥性肺炎の基礎研究

    海老原 覚, 岡崎 達馬

    Journal of Clinical Rehabilitation　27　(9)　892-896　2018/08

    Publisher: 医歯薬出版(株)

    ISSN： 0918-5259

  25. リンパ管を標的とした新規胸膜炎治療の検討

    小林誠, 岡崎達馬, 突田容子, 小松理世, 杉浦久敏, 海老原覚, 一ノ瀬正和

    日本呼吸器学会誌(Web)　7　209　2018/03/10

    ISSN： 2186-5884

  26. EGFR遺伝子変異陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する

    突田容子, 藤野直也, 宮内栄作, 井上彰, 板倉康司, 山田充啓, 岡崎達馬, 桜田晃, 杉浦久敏, 岡田克典, 一ノ瀬正和

    日本呼吸器学会誌(Web)　7　(増刊)　267-267　2018/03/10

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5884

  27. リンパ管を標的とした新規胸膜炎治療の検討

    小林 誠, 岡崎 達馬, 突田 容子, 小松 理世, 杉浦 久敏, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　209-209　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  28. EGFR遺伝子変異陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する

    突田 容子, 藤野 直也, 宮内 栄作, 井上 彰, 板倉 康司, 山田 充啓, 岡崎 達馬, 桜田 晃, 杉浦 久敏, 岡田 克典, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　267-267　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

  29. リンパ管を標的とした新規胸膜炎治療の検討

    小林 誠, 岡崎 達馬, 突田 容子, 小松 理世, 杉浦 久敏, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　209-209　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  30. EGFR遺伝子変異陽性肺腺癌においてAXLキナーゼは免疫抑制分子を制御する

    突田 容子, 藤野 直也, 宮内 栄作, 井上 彰, 板倉 康司, 山田 充啓, 岡崎 達馬, 桜田 晃, 杉浦 久敏, 岡田 克典, 一ノ瀬 正和

    日本呼吸器学会誌　7　(増刊)　267-267　2018/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  31. Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5 Peer-reviewed

    Tsukita Yoko, Okazaki Tatsuma, Sato Yasufumi, Yagita Hideo, Ichinose Masakazu

    CANCER SCIENCE　109　120　2018/01

    ISSN： 1349-7006

  32. 3) Sarcopenia and Frailty in Patients with Respiratory Diseases

    Ebihara Satoru, Okazaki Tatsuma

    Nihon Naika Gakkai Zasshi　107　(9)　1708-1712　2018

    Publisher: The Japanese Society of Internal Medicine

    DOI： 10.2169/naika.107.1708 　

    ISSN： 0021-5384

  33. 【高齢者の誤嚥・肺炎予防up-to-date】サルコペニアと誤嚥性肺炎の関係

    岡崎 達馬, 小松 理世, 突田 容子, 小林 誠, 二瓶 真由美, 海老原 孝枝, 一ノ瀬 正和

    Geriatric Medicine　55　(11)　1221-1224　2017/11

    Publisher: (株)ライフ・サイエンス

    ISSN： 0387-1088

  34. 【高齢者の誤嚥・肺炎予防up-to-date】 サルコペニアと誤嚥性肺炎の関係

    岡崎 達馬, 小松 理世, 突田 容子, 小林 誠, 二瓶 真由美, 海老原 孝枝, 一ノ瀬 正和

    Geriatric Medicine　55　(11)　1221-1224　2017/11

    Publisher: (株)ライフ・サイエンス

    ISSN： 0387-1088

  35. スニチニブは腫瘍の微小環境を改善してエフェクターT細胞を浸潤させDR-5を介した抗腫瘍免疫療法の効果を増強する

    突田 容子, 岡崎 達馬, 佐藤 靖史, 八木田 秀雄, 一ノ瀬 正和

    日本癌学会総会記事　76回　E-1057　2017/09

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  36. UHPLC-UVによるエルロチニブ及び代謝物の同時測定法と非小細胞肺がん患者血中濃度測定への応用

    須賀 隆浩, 島田 美樹, 前川 正充, 鈴木 裕之, 森 大, 岡崎 達馬, 井上 彰, 山口 浩明, 眞野 成康

    臨床化学　46　(Suppl.1)　291-291　2017/09

    Publisher: (一社)日本臨床化学会

    ISSN： 0370-5633

    eISSN： 2187-4077

  37. スニチニブは腫瘍の微小環境を改善してエフェクターT細胞を浸潤させDR-5を介した抗腫瘍免疫療法の効果を増強する

    突田 容子, 岡崎 達馬, 佐藤 靖史, 八木田 秀雄, 一ノ瀬 正和

    日本癌学会総会記事　76回　E-1057　2017/09

    Publisher: 日本癌学会

    ISSN： 0546-0476

  38. UHPLC-UVによるエルロチニブ及び代謝物の同時測定法と非小細胞肺がん患者血中濃度測定への応用

    須賀 隆浩, 島田 美樹, 前川 正充, 鈴木 裕之, 森 大, 岡崎 達馬, 井上 彰, 山口 浩明, 眞野 成康

    臨床化学　46　(Suppl.1)　291-291　2017/09

    Publisher: (一社)日本臨床化学会

    ISSN： 0370-5633

  39. 誤嚥性肺炎の新規治療標的としてのリンパ管と筋肉:サルコペニアを含めた実験モデルと症例の解析

    岡崎達馬, 小松理世, 小林誠, 突田容子, 二瓶真由美, 海老原覚, 海老原孝枝, 一ノ瀬正和

    日本老年医学会雑誌　54　(Suppl.)　110-110　2017/05/25

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  40. 誤嚥性肺炎up to date 誤嚥性肺炎の新規治療標的としてのリンパ管と筋肉 サルコペニアを含めた実験モデルと症例の解析

    岡崎 達馬, 小松 理世, 小林 誠, 突田 容子, 二瓶 真由美, 海老原 覚, 海老原 孝枝, 一ノ瀬 正和

    日本老年医学会雑誌　54　(Suppl.)　110-110　2017/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  41. 好酸球性肺炎の像を呈した肺接合菌症の1例

    平野 泰三, 山田 充啓, 村上 康司, 佐藤 慶, 玉井 ときわ, 高橋 秀徳, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本内科学会雑誌　106　(5)　1006-1011　2017/05

    Publisher: (一社)日本内科学会

    DOI： 10.2169/naika.106.1006 　

    ISSN： 0021-5384

    eISSN： 1883-2083

    More details Close

    74歳男。発熱、呼吸困難を主訴とした。10日前に腹部大動脈破裂に対しY-graft置換術を施行されていた。胸部CTにて左上葉の浸潤影の悪化を認め、喀痰培養にてメチシリン耐性黄色ブドウ球菌を検出したため、院内肺炎を疑った。メロペネム・テイコプラニンの抗菌薬にて加療したが改善を認めず、気管支鏡検査を施行した結果、気管支肺胞洗浄液にて好酸球比率が82%と増加し、検鏡にて真菌(糸状菌)を認めた。真菌培養にて接合菌が培養陽性となり、遺伝子検査からCunninghamellla bertholletiaeと同定され、好酸球性肺炎と診断した。抗真菌薬とプレドニゾロンにて治療を開始したが敗血症性ショックの病像を呈し、第39病日に死亡した。病理解剖では両肺の上葉を主体として広く壊死巣が観察され、病巣内には糸状菌を多数認めた。また、心筋、甲状腺、腎臓、脾臓においても同様に糸状菌塊と炎症性細胞浸潤を認め、播種性浸潤性接合菌症と最終診断した。

  42. Effects of a combination of antiangiogenic and antilymphangiogenic therapies on a death receptor-5 mediated antitumor immunotherapy in mice. Peer-reviewed

    Yoko Tsukita, Tatsuma Okazaki, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose

    JOURNAL OF CLINICAL ONCOLOGY　35　2017/05

    DOI： 10.1200/JCO.2017.35.15_suppl.e23001 　

    ISSN： 0732-183X

    eISSN： 1527-7755

  43. 誤嚥性肺炎はマイオカインを誘導しサルコペニアを悪化させる

    小松 理世, 岡崎 達馬, 突田 容子, 小林 誠, 二瓶 真由美, 杉浦 久敏, 海老原 孝枝, 海老原 覚, 一ノ瀬 正和

    日本老年医学会雑誌　54　(Suppl.)　149-149　2017/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  44. 誤嚥性肺炎はマイオカインを誘導し筋肉を萎縮させる

    小松理世, 岡崎達馬, 突田容子, 小林誠, 二瓶真由美, 杉浦久敏, 海老原覚, 一ノ瀬正和

    日本呼吸器学会誌(Web)　6　116　2017/03/10

    ISSN： 2186-5884

  45. 誤嚥性肺炎はマイオカインを誘導し筋肉を萎縮させる

    小松 理世, 岡崎 達馬, 突田 容子, 小林 誠, 二瓶 真由美, 杉浦 久敏, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　6　(増刊)　116-116　2017/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  46. 誤嚥性肺炎はマイオカインを誘導し筋肉を萎縮させる

    小松 理世, 岡崎 達馬, 突田 容子, 小林 誠, 二瓶 真由美, 杉浦 久敏, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　6　(増刊)　116-116　2017/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  47. 両下肢麻痺を来たした肺真菌症の1例

    佐藤 慶, 山田 充啓, 平野 泰三, 三橋 善哉, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本内科学会雑誌　106　(3)　591-595　2017/03

    Publisher: (一社)日本内科学会

    DOI： 10.2169/naika.106.591 　

    ISSN： 0021-5384

    eISSN： 1883-2083

    More details Close

    症例は51歳男性で、以前より左上葉に空洞性病変を指摘されていた。タイヤを持ち上げた際に腰痛を自覚し、その後、徐々に歩行困難となった。CT、MRIで脊椎への浸潤を伴う左上葉空洞影を認めた。両下肢に不全麻痺および深部感覚低下、腱反射低下を認めた。軽度閉塞性換気障害を認めた。両下肢の麻痺が進行し、排尿障害などの症状も出現したため、確定診断および除圧を目的として胸椎(Th2〜Th4)椎弓切除術を施行した。検体の病理組織学的検査により酵母様真菌を検出し、肺真菌症・脊椎浸潤(硬膜内髄外膿瘍)と診断した。術後よりアムホテリシンBを開始したが、腎機能障害のためホスフルコナゾールに変更した。治療開始後30日目に施行したCTでは脊椎へ浸潤する左上葉空洞影は縮小し、両下肢麻痺も徐々に改善した。フルコナゾールに変更し、杖歩行可能な状態まで改善し、排尿も自己導尿で対応可能となった。治療開始後56日目にリハビリ目的に転院した。

  48. トシリズマブ(抗IL-6R抗体)による加療中に発症した肺結核の1例

    山田 充啓, 三橋 善哉, 京極 自彦, 三浦 絵美里, 東條 裕, 藤野 直也, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    結核　92　(1)　51-51　2017/01

    Publisher: (一社)日本結核・非結核性抗酸菌症学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  49. トシリズマブ(抗IL-6R抗体)による加療中に発症した肺結核の1例

    山田 充啓, 三橋 善哉, 京極 自彦, 三浦 絵美里, 東條 裕, 藤野 直也, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    結核　92　(1)　51-51　2017/01

    Publisher: (一社)日本結核病学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  50. 好酸球性肺炎を合併したIgG4関連疾患の1例

    東條 裕, 岡崎 達馬, 三浦 絵美里, 京極 自彦, 三橋 善哉, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　36　(1-2)　92-93　2016/10

    Publisher: 日本サルコイドーシス

    ISSN： 1883-1273

  51. 肺及び骨病変を伴う成人発症の多臓器型ランゲルハンス細胞組織球症の1例

    丹野 篤, 岡崎 達馬, 三浦 絵美里, 村松 聡士, 佐藤 輝幸, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　36　(1-2)　93-93　2016/10

    Publisher: 日本サルコイドーシス

    ISSN： 1883-1273

  52. 抗血管新生と抗リンパ管新生療法の組み合わせは抗腫瘍免疫療法の効果を増強する

    突田 容子, 岡崎 達馬, 八木田 秀雄, 一ノ瀬 正和

    日本癌学会総会記事　75回　P-2126　2016/10

    Publisher: (一社)日本癌学会

    ISSN： 0546-0476

  53. EBUS-TBNAで診断に至った肺原発血管肉腫の1例

    京極 自彦, 岡崎 達馬, 三浦 絵美里, 突田 容子, 田中 里江, 東條 裕, 三橋 善哉, 宮内 栄作, 杉浦 久敏, 一ノ瀬 正和, 高橋 信

    肺癌　56　(5)　406-406　2016/10

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  54. 尺骨動脈閉塞症を合併した肺腺癌の1例

    山中 駿, 宮内 栄作, 平野 泰三, 佐藤 慶, 高橋 秀徳, 村上 康司, 玉井 ときわ, 山田 充啓, 岡崎 達馬, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和, 井上 彰

    肺癌　56　(5)　404-404　2016/10

    Publisher: (NPO)日本肺癌学会

    ISSN： 0386-9628

    eISSN： 1348-9992

  55. 好酸球性肺炎を合併したIgG4関連疾患の1例

    東條 裕, 岡崎 達馬, 三浦 絵美里, 京極 自彦, 三橋 善哉, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　36　(1-2)　92-93　2016/10

    Publisher: 日本サルコイドーシス

    ISSN： 1883-1273

  56. 肺及び骨病変を伴う成人発症の多臓器型ランゲルハンス細胞組織球症の1例

    丹野 篤, 岡崎 達馬, 三浦 絵美里, 村松 聡士, 佐藤 輝幸, 玉田 勉, 杉浦 久敏, 一ノ瀬 正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　36　(1-2)　93-93　2016/10

    Publisher: 日本サルコイドーシス

    ISSN： 1883-1273

  57. 抗血管新生と抗リンパ管新生療法の組み合わせは抗腫瘍免疫療法の効果を増強する

    突田 容子, 岡崎 達馬, 八木田 秀雄, 一ノ瀬 正和

    日本癌学会総会記事　75回　P-2126　2016/10

    ISSN： 0546-0476

  58. EBUS-TBNAで診断に至った肺原発血管肉腫の1例

    京極 自彦, 岡崎 達馬, 三浦 絵美里, 突田 容子, 田中 里江, 東條 裕, 三橋 善哉, 宮内 栄作, 杉浦 久敏, 一ノ瀬 正和, 高橋 信

    気管支学　38　(5)　445-446　2016/09

    Publisher: (NPO)日本呼吸器内視鏡学会

    ISSN： 0287-2137

    eISSN： 2186-0149

  59. 誤嚥性肺炎はマイオカイン及び筋萎縮を誘導する~動物モデルを用いた解析~

    岡崎達馬, 小松理世, 小林誠, 二瓶真由美, 突田容子, 海老原覚, 一ノ瀬正和

    日本老年医学会雑誌　53　143　2016/05/18

    ISSN： 0300-9173

  60. 誤嚥性肺炎はマイオカイン及び筋萎縮を誘導する 動物モデルを用いた解析

    岡崎 達馬, 小松 理世, 小林 誠, 二瓶 真由美, 突田 容子, 海老原 覚, 一ノ瀬 正和

    日本老年医学会雑誌　53　(Suppl.)　143-143　2016/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  61. 誤嚥性肺炎は呼吸筋,骨格筋,嚥下筋の萎縮を誘導する

    小松理世, 岡崎達馬, 二瓶真由美, 小林誠, 突田容子, 杉浦久敏, 海老原覚, 一ノ瀬正和

    日本呼吸器学会誌　5　(増刊)　175-175　2016/03/10

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  62. 正常及び敗血症モデルマウスの胸膜(横隔膜)のリンパ管の解析

    小林誠, 岡崎達馬, 二瓶真由美, 突田容子, 小松理世, 玉井ときわ, 杉浦久敏, 一ノ瀬正和

    日本呼吸器学会誌　5　(増刊)　304-304　2016/03/10

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  63. 誤嚥性肺炎は呼吸筋、骨格筋、嚥下筋の萎縮を誘導する

    小松 理世, 岡崎 達馬, 二瓶 真由美, 小林 誠, 突田 容子, 杉浦 久敏, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　5　(増刊)　175-175　2016/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  64. 正常及び敗血症モデルマウスの胸膜(横隔膜)のリンパ管の解析

    小林 誠, 岡崎 達馬, 二瓶 真由美, 突田 容子, 小松 理世, 玉井 ときわ, 杉浦 久敏, 一ノ瀬 正和

    日本呼吸器学会誌　5　(増刊)　304-304　2016/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  65. 呼吸器疾患解析・治療応用が期待されるテクノロジー 脈管、免疫系をターゲットとした呼吸器疾患解析と治療応用

    岡崎 達馬, 一ノ瀬 正和

    日本呼吸器学会誌　5　(増刊)　31-31　2016/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  66. 【GERD】病態に及ぼすGERDの影響 嚥下性肺炎との関係

    岡崎 達馬, 一ノ瀬 正和

    JOHNS　32　(2)　227-230　2016/02

    Publisher: (株)東京医学社

    ISSN： 0910-6820

  67. 誤嚥性肺炎における脈管系の解析及びサルコペニア誘導の可能性

    岡崎 達馬, 二瓶 真由美, 海老原 覚, 小林 誠, 一ノ瀬 正和

    日本老年医学会雑誌　52　(Suppl.)　47-47　2015/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  68. 東北大学病院呼吸器バイオバンクの現状と課題

    宮内 栄作, 光石 陽一郎, 東出 直樹, 椎原 淳, 三橋 善哉, 村松 聡士, 小林 誠, 佐藤 輝幸, 玉井 ときわ, 山田 充啓, 小荒井 晃, 井上 彰, 岡崎 達馬, 大河内 眞也, 玉田 勉, 杉浦 久敏, 菊地 利明, 一ノ瀬 正和

    日本呼吸器学会誌　4　(増刊)　151-151　2015/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  69. 【嚥下障害と誤嚥性肺炎】誤嚥性肺炎の治療 内科の立場から

    岡崎 達馬, 一ノ瀬 正和

    ENTONI　(175)　31-37　2015/01

    Publisher: (株)全日本病院出版会

    ISSN： 1346-2067

  70. 誤嚥性肺炎症例とマウスモデルにおける慢性炎症、リンパ管新生とその阻害効果

    岡崎 達馬, 海老原 覚, 海老原 孝枝, 一ノ瀬 正和

    日本老年医学会雑誌　51　(Suppl.)　81-81　2014/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  71. 誤嚥性肺炎マウスモデルにおけるリンパ管新生の意義の検討

    小林 誠, 岡崎 達馬, 二瓶 真由美, 菊地 利明, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　3　(増刊)　276-276　2014/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  72. 誤嚥性肺炎マウスモデルにおけるリンパ管新生の意義の検討

    小林 誠, 岡崎 達馬, 二瓶 真由美, 菊地 利明, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　3　(増刊)　276-276　2014/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  73. クローン病に対する長期抗TNF抗体療法中に発症したサルコイドーシスの1例

    沼倉 忠久, 玉田 勉, 奈良 正之, 菊地 利明, 岡崎 達馬, 小林 誠, 室井 美穂, 高木 承, 江石 義信, 一ノ瀬 正和

    日本サルコイドーシス/肉芽腫性疾患学会雑誌　33　(サプリメント号)　50-50　2013/10

    Publisher: 日本サルコイドーシス

    ISSN： 1883-1273

  74. 新規通常型誤嚥性肺炎マウルモデルの確立とその脈管系の解析

    岡崎 達馬, 海老原 覚, 海老原 孝枝, 一ノ瀬 正和

    日本老年医学会雑誌　50　(Suppl.)　55-56　2013/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  75. 新規通常型誤嚥性肺炎マウスモデルの確立とその脈管系の解析

    二瓶 真由美, 岡崎 達馬, 小林 誠, 菊地 利明, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　2　(増刊)　249-249　2013/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  76. 新規通常型誤嚥性肺炎マウスモデルの確立とその脈管系の解析

    二瓶 真由美, 岡崎 達馬, 小林 誠, 菊地 利明, 海老原 覚, 一ノ瀬 正和

    日本呼吸器学会誌　2　(増刊)　249-249　2013/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 2186-5876

    eISSN： 2186-5884

  77. AMP活性化プロテインキナーゼ活性化と悪性中皮腫

    牛 凱軍, 海老原 覚, 浅田 成紀, 矢満田 慎介, 岡崎 達馬, 永富 良一, 荒井 啓行

    日本呼吸器学会雑誌　48　(増刊)　251-251　2010/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  78. AMP活性化プロテインキナーゼ活性化と悪性中皮腫

    牛 凱軍, 海老原 覚, 浅田 成紀, 矢満田 慎介, 岡崎 達馬, 永富 良一, 荒井 啓行

    日本呼吸器学会雑誌　48　(増刊)　251-251　2010/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  79. Impact of physical activity and performance on medical care costs among the Japanese elderly

    Yang G, Niu K, Fujita K, Hozawa A, Ohmori-Matsuda K, Kuriyama S, Nakaya N, Ebihara S, Okazaki T, Guo H, Miura C, Takahashi H, Arai H, Tsuji I, Nagatomi R

    Geriatr Gerontol Int　00　(00)　000-000　2010

    DOI： 10.1111/j.1447-0594.2010.00651.x. 　

  80. 固形腫瘍に対するエリスロポエチン製剤の効果

    海老原 覚, 岡崎 達馬, 浅田 成紀, 矢満田 慎介, 海老原 孝枝, 荒井 啓行

    日本呼吸器学会雑誌　47　(増刊)　206-206　2009/05

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  81. Erythropoietin promotes the growth of tumors lacking its receptor and decreases survival of tumor-bearing mice by enhancing angiogenesis

    Tatsuma Okazaki, Satoru Ebihara, Masanori Asada, Shinsuke Ymanda, Kaijun Niu, Hiroyuki Arai

    NEOPLASIA　10　(9)　932-939　2008/09

    DOI： 10.1593/neo.08140 　

    ISSN： 1476-5586

  82. Delta-like 4阻害剤によるマウス肺扁平上皮癌に対する分子標的治療

    矢満田 慎介, 浅田 成紀, 牛 凱軍, 岡崎 達馬, 浅村 孝昭, 山崎 都, 山口 典子, 八木田 秀雄, 海老原 覚, 山谷 睦雄

    日本呼吸器学会雑誌　46　(増刊)　326-326　2008/05

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  83. 固形腫瘍に対するM-CSF製剤の効果とその機序

    海老原 覚, 岡崎 達馬, 浅田 成紀, 矢満田 慎介, 山崎 都, 大類 孝, 山谷 睦雄

    日本呼吸器学会雑誌　46　(増刊)　326-326　2008/05

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  84. アセチルコリンエステラーゼ阻害剤の中止により麻痺性イレウスを呈した1例

    古川 勝敏, 岡崎 達馬, 山谷 睦雄, 荒井 啓行

    日本老年医学会雑誌　44　(1)　137-137　2007/01

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  85. 化学放射線療法後に軽度放射線肺臓炎を発症した肺癌患者における予後に関する研究

    吉田 元樹, 安田 浩康, 中山 勝敏, 神田 暁郎, 佐々木 陽彦, 海老原 覚, 浅田 成紀, 鈴木 朋子, 岡崎 達馬, 山崎 都, 矢満田 慎介, 山谷 睦雄

    日本呼吸器学会雑誌　44　(増刊)　265-265　2006/06

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  86. 健常高齢ex-smokerにおける咳反射の検討

    海老原 覚, 海老原 孝枝, 岡崎 達馬, 大類 孝, 山谷 睦雄

    日本老年医学会雑誌　43　(Suppl.)　131-131　2006/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  87. Macrophage Colony Stimulating Factor (M-CSF)による骨格筋の細胞死抑制作用

    矢満田 慎介, 岡崎 達馬, 海老原 覚, 大類 孝, 山谷 睦雄

    日本老年医学会雑誌　43　(Suppl.)　140-140　2006/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  88. アンチエイジングの最前線 サイトカインによる筋肉の分子標的アンチエイジング

    岡崎 達馬

    日本老年医学会雑誌　43　(Suppl.)　33-33　2006/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  89. 高齢者誤嚥性肺炎リスクファクターに対するカプサイシントローチの効果

    海老原 孝枝, 高橋 秀徳, 海老原 覚, 渡戸 亜矢, 岡崎 達馬, 佐々木 陽彦, 根本 都, 山谷 睦雄, 荒井 啓行, 佐々木 英忠

    日本老年医学会雑誌　42　(Suppl.)　58-58　2005/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  90. 高齢施設入所者におけるテオフィリンの嚥下反射に対する影響

    海老原 覚, 海老原 孝枝, 岡崎 達馬, 佐々木 英忠

    日本呼吸器学会雑誌　43　(増刊)　173-173　2005/04

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  91. BCG接種後の皮膚結核をMultiplex PCR法により同定しえた一例

    岡崎 達馬, 海老原 覚, 高橋 秀徳, 浅田 成紀, 佐々木 英忠

    日本呼吸器学会雑誌　43　(増刊)　207-207　2005/04

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  92. Molecular differentiation of Mycobacterium Tuberculosis complex on the basis of genomic deletions

    Ebihara S, Okazaki T, Ebihara T, Ohrui T, Yamaya M, Asada M, Yasuda H, Yamazaki M, Seki M, Toida I

    Res. Adv. In Microbiology　5　35-45　2005

  93. マクロファージコロニー刺激因子は末梢血中の血管内皮前駆細胞を増加させ血管新生を促進する

    岡崎 達馬, 海老原 覚, 高橋 秀徳, 浅田 成紀, 神田 暁郎, 佐々木 秀忠

    炎症・再生　24　(4)　513-513　2004/07

    Publisher: (一社)日本炎症・再生医学会

    ISSN： 1346-8022

    eISSN： 1880-5795

  94. 施設入所高齢者における口腔ケアによる咳反射の改善

    海老原 覚, 海老原 孝枝, 中條 瑞枝, 渡戸 亜矢, 岡崎 達馬, 高橋 秀徳, 佐々木 英忠

    日本老年医学会雑誌　41　(Suppl.)　137-137　2004/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  95. 喀痰喀出困難高齢患者に対するmechanical insufflation-exsufflation(MI-E)とフラッターの組み合わせの効果

    佐々木 陽彦, 海老原 覚, 山谷 睦雄, 岡崎 達馬, 神田 暁郎, 根本 都, 渡戸 亜矢, 佐々木 英忠

    日本老年医学会雑誌　41　(Suppl.)　163-163　2004/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  96. BCG接種後,他の部位に結核性皮下膿瘍をきたした1例

    岡崎 達馬, 海老原 覚, 高橋 秀徳, 浅田 成紀, 山谷 睦雄, 佐々木 英忠, 大戸 秀恭, 佐藤 明正, 関 昌明

    結核　79　(4)　321-321　2004/04

    Publisher: (一社)日本結核・非結核性抗酸菌症学会

    ISSN： 0022-9776

    eISSN： 1884-2410

  97. ドーパミンレセプターと肺癌増殖の関係

    浅田 成紀, 海老原 覚, 岡崎 達馬, 高橋 秀徳, 佐々木 英忠

    日本呼吸器学会雑誌　42　(増刊)　91-91　2004/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  98. 第Xa因子阻害薬のマウス肺癌移植皮下腫瘍に対する効果

    高橋 秀徳, 海老原 覚, 神田 暁郎, 岡崎 達馬, 浅田 成紀, 佐々木 英忠

    日本呼吸器学会雑誌　42　(増刊)　180-180　2004/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  99. 高齢施設入所者における口腔ケアの咳反射に対する影響

    海老原 覚, 渡戸 綾, 海老原 孝枝, 高橋 秀徳, 岡崎 達馬, 浅田 成紀, 中條 瑞枝, 佐々木 英忠

    日本呼吸器学会雑誌　42　(増刊)　138-138　2004/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  100. NF‐κBの活性化はTNFにより誘導されるROSの蓄積を抑制する

    中野裕康, 左近幸子, XUE X, 武川睦寛, 笹月朋成, 岡崎達馬, 小島裕子, PIA J‐H, 土井貴裕

    日本分子生物学会年会プログラム・講演要旨集　26th　473　2003/11/25

  101. ロキソプロフェンによる腫瘍制御

    神田 暁郎, 海老原 覚, 高橋 秀徳, 岡崎 達馬, 安田 浩康, 山谷 睦雄, 佐々木 英忠

    日本老年医学会雑誌　40　(Suppl.)　118-118　2003/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  102. 健常人における塩酸ドキサプラム投与の吸気抵抗負荷時呼吸困難感に及ぼす影響

    海老原 覚, 海老原 孝枝, 神田 暁郎, 高橋 秀徳, 岡崎 達馬, 安田 浩康, 佐々木 陽彦, 佐々木 英忠

    日本呼吸器学会雑誌　41　(増刊)　119-119　2003/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  103. エンドトキシンによるマウス肺におけるVEGF receptor 2の変化

    神田 暁郎, 海老原 覚, 岡崎 達馬, 佐々木 英忠

    日本呼吸器学会雑誌　41　(増刊)　123-123　2003/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  104. 非小細胞肺癌におけるHeparan degrading enzyme(Heparanase)活性とその病理学的因子及び予後との関連の検討

    高橋 秀徳, 海老原 覚, 神田 暁郎, 岡崎 達馬, 久保 裕司, 山田 充啓, 鈴木 聡, 佐々木 英忠

    日本呼吸器学会雑誌　41　(増刊)　142-142　2003/03

    Publisher: (一社)日本呼吸器学会

    ISSN： 1343-3490

  105. cDNAマイクロアレイを用いたTNF刺激時に誘導される遺伝子群の解析

    小原井 朋成, 岡崎 達馬, 多田 久里守, 八木田 秀雄, 奥村 康, 中野 裕康

    日本免疫学会総会・学術集会記録　32　80-80　2002/10

    Publisher: (NPO)日本免疫学会

    ISSN： 0919-1984

  106. cDNAマイクロアレイを用いたTNF刺激時に誘導される遺伝子群の解析

    小原井 朋成, 岡崎 達馬, 多田 久里守, 八木田 秀雄, 奥村 康, 中野 裕康

    日本免疫学会総会・学術集会記録　32　80-80　2002/10

    ISSN： 0919-1984

  107. テオフィリン製剤のパーキンソン病発症における予防効果

    海老原 覚, 神田 暁郎, 高橋 秀徳, 岡崎 達馬, 荒井 啓行, 佐々木 英忠

    日本老年医学会雑誌　39　(Suppl.)　96-96　2002/05

    Publisher: (一社)日本老年医学会

    ISSN： 0300-9173

  108. TNF受容体を介するシグナル伝達経路

    岡崎 達馬, 中野 裕康

    最新医学　56　(8)　1843-1847　2001/08

    Publisher: (株)最新医学社

    ISSN： 0370-8241

  109. 新規抗アポトーシス遺伝子の同定及びその機能解析

    小原井朋成, 岡崎達馬, 左近幸子, 片野光男, 北村俊雄, 八木田秀雄, 奥村康, 中野裕康

    日本分子生物学会年会プログラム・講演要旨集　23rd　563　2000/11/25

  110. ブレオマイシン肺炎モデルにおけるT細胞の役割

    岡崎 達馬, 八木田 秀雄, 奥村 康, 末吉 徳芳

    順天堂医学　46　(1)　103-104　2000/06

    Publisher: 順天堂医学会

    ISSN： 0022-6769

  111. ブレオマイシン肺炎モデルにおけるT細胞の役割

    岡崎 達馬, 八木田 秀雄, 奥村 康, 末吉 徳芳

    順天堂医学　46　(1)　103-104　2000/06

    ISSN： 0022-6769

  112. 免疫系におけるCD30/CD153の生理的機能の基礎的検討

    下里 修, 中野 康裕, 服部 浩一, 岡崎 達馬

    順天堂医学　45　(3)　425-426　1999/12

    Publisher: 順天堂医学会

    ISSN： 0022-6769

  113. ブレオマイシン肺炎モデルにおけるT細胞の役割

    岡崎 達馬, 竹田 和由, 下里 修, 中野 裕康, 八木田 秀雄, 奥村 康

    日本免疫学会総会・学術集会記録　29　71-71　1999/10

    Publisher: (NPO)日本免疫学会

    ISSN： 0919-1984

  114. ブレオマイシン肺炎モデルにおけるT細胞の役割

    岡崎 達馬, 竹田 和由, 下里 修, 中野 裕康, 八木田 秀雄, 奥村 康

    日本免疫学会総会・学術集会記録　29　71-71　1999/10

    ISSN： 0919-1984

  115. 乳腺アポクリン癌の1例

    岡崎 達馬, 三浦 一章, 澤 直哉, 岡本 道孝, 高橋 秀禎, 今野 文博, 石橋 悟, 小柳 雅是, 井上 国彦, 堀 義生

    東北医学雑誌　111　(1)　38-38　1999/08

    Publisher: 東北医学会

    ISSN： 0040-8700

  116. 軟骨化生を伴った乳癌の2例

    井上 国彦, 三浦 一章, 澤 直哉, 岡本 道孝, 高橋 秀禎, 今野 文博, 石橋 悟, 小柳 雅是, 岡崎 達馬, 堀 義生

    東北医学雑誌　111　(1)　39-39　1999/08

    Publisher: 東北医学会

    ISSN： 0040-8700

  117. 当科における小児の外科的疾患 1995年,1996年の集計

    澤 直哉, 二瓶 義博, 平宇 健治, 平野 孝幸, 千葉 知史, 佐々木 英之, 井上 国彦, 岡崎 達馬, 堀 義生, 清治 和将, 任 幹夫, 山田 昌宏, 小柳 雅是, 星田 徹, 石橋 悟, 長谷川 達郎, 今野 文博, 高橋 秀禎, 岡本 道孝, 三浦 一章

    八戸市立市民病院医誌　19　(1)　19-23　1999/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

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    1)入院数は1995年が185名,1996年が151名であった. 2)手術件数は1995年が130件,1996年が110件であった.麻酔別では全麻下の手術が両年とも95%以上で殆どを示した. 3)年齢別では例年と同じで多い順に幼児,乳児,学童,新生児となった.新生児は1995年が6例で9件の手術を行った.1996年は4例,7件の手術であった. 4)疾患では鼠径ヘルニアが最も多くついで虫垂炎であり,両疾患で全手術件数の約75%を占めていた.3位は1995年が鎖肛と肥厚性幽門狭窄症で各々2件,1996年はHirschsprung病で3件あった. 5)年齢別に疾患を多い順に示した

  118. CABG術後に発症した肺動静脈瘻の1手術例

    岡本 道孝, 三浦 一章, 澤 直哉, 高橋 秀禎, 今野 文博, 堀 義生, 井上 国彦, 岡崎 達馬, 平宇 健治, 平野 孝幸

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY　47　(Suppl.)　30-30　1999/03

    Publisher: シュプリンガー・ジャパン(株)

    ISSN： 1344-4964

    eISSN： 1863-2092

  119. 当院における小児の外科的疾患 1993年1994年の集計

    澤 直哉, 井上 国彦, 岡崎 達馬

    八戸市立市民病院医誌　18　(2)　124-127　1998/05

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

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    1993年と1994年の小児の外科的疾患につきまとめた. 1)手術件数は1993年が152件,1994年が133件であった.麻酔別では全麻が1993年150件,1994年129件であった. 2)年齢別では幼児,乳児,学童,新生児の順に多かった.新生児は1993年が6件,1994年が3件であった. 3)疾患は鼠径ヘルニアが最も多く,次いで急性虫垂炎であった.他は年間数例程度であった. 4)年齢別に疾患を多い順に示し,その概要を述べた

  120. 乳腺管状癌の一例

    岡崎 達馬, 三浦 一彰, 澤 直哉

    八戸市立市民病院医誌　18　(1)　30-33　1997/06

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

  121. 当院における小児熱傷症例の検討

    岡崎 達馬, 澤 直哉, 三浦 一章

    八戸市立市民病院医誌　18　(1)　44-47　1997/06

    Publisher: 八戸市立市民病院

    ISSN： 0389-5122

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    当院で昭和61年より平成8年までに経験した25例の入院小児熱傷患児についてまとめた.年齢分布は7ヵ月から11歳で平均年齢は3.1歳だった.うち2歳以下が69%を占めた.重症度分類をBurn Indexに基づいて行うと0以上5未満が12例48%, 5以上10未満が4例16%, 10以上15未満が同じく4例16%, 15以上が5例20%であった.重症患者の受傷後24時間の輸液量をSchreinerの公式と比較すると,80%の患児でほぼ一致した値が得られたが,Burn Index 45の重症々例では2倍以上の輸液量を要した.投与コロイド量において同公式と比べ,平均で4.11倍と大きな解離を認めた

  122. A case of tubular carcinoma of the breast.

    岡崎達馬, 三浦一章, 岡本道孝, 高橋秀禎, 今野文博, 小柳雅是, 井上国彦, 堀義生, 方山揚誠

    八戸市立市民病院医誌　18　(1)　30-33　1997/06

    ISSN： 0389-5122

  123. 乳腺管状癌の1例

    岡崎 達馬

    青森県自治体医学会誌　(23)　27-27　1994/08

    Publisher: 青森県自治体病院開設者協議会

    ISSN： 0913-4581

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Research Projects 11

  1. サルコペニアと脈管を標的とする新規高齢者肺炎対策の開発

    岡崎 達馬, 海老原 孝枝, 出江 紳一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2026/03/31

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    1) 鶴ケ谷コホートで癌等の３大死因のうち低肺活量群の肺炎による死亡リスク増大を示した。本コホートは2002と2003年に呼吸機能や脚力等を調べ１１年間死因を追跡した。癌、心血管疾患、肺炎、の３大死因のうち低肺活量群の肺炎による死亡リスク増大を示し強い脚力による死亡リスク低下を示した。そして論文として報告した. Shiokawa N, Okazaki T, 他 Association between low forced vital capacity and high pneumonia mortality, and impact of muscle power. Journal of Clinical Medicine May12(9), 3272. 2023 <BR> 2) 呼吸筋力増強の肺炎再発予防効果を確認するため、高齢肺炎症例の前向き縦断介入研究を実施している。このため石巻市斉藤病院の入院肺炎症例(70歳以上)を対象としてエントリーしている。 <BR> 3) 胸膜脈管系の正常解剖や膿胸による変化を観察するためマウス胸壁胸膜可視化モデルで脈管の解剖やリンパ管の種類を各々の標識抗体群で免疫染色している。これまで共焦点顕微鏡で胸壁胸膜を撮影し３次元画像解析ソフトで立体構造を同定した。また胸膜炎を発症させリンパ管や血管の新生、リモデリングを確認した。これらを論文として報告した。 Ren Y, Okazaki T 他 Anatomy and function of the lymphatic vessels in the parietal pleura and their plasticity under inflammation in mice. Microvascular Research Jul;148:104546. 2023

  2. サルコペニアと脈管を標的とする新規高齢者肺炎対策の開発

    岡崎 達馬, 出江 紳一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(B)

    Category: 基盤研究(B)

    Institution: 東北大学

    2022/04/01 - 2026/03/31

  3. Development of a novel therapeutic strategy of dysphagia focusing on the cell-protection and anti-inflammatory effects of the transcription factor Nrf2.

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  4. Research of a novel treatment for dysphagia focusing on cell protection and anti-inflammatory effects of transcription factor Nrf2

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2022/04/01 - 2025/03/31

  5. Anti-angiogenic and lymphangiogenic therapy improves the tumor microenvironment and enhances the effectiveness of immunotherapy

    Okazaki Tatsuma

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2022/03/31

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    In this study, we identified a previously unknown normal anatomy of lymphatics and blood vessels in the pleura covering the mouse chest wall and diaphragm. We immuno-stained the chest wall and diaphragm with markers for lymphatics and blood vessels. We observed and identified and their anatomy using a microscope. Lymphatics include initial and collecting lymphatics. We identified their distribution in the pleura. We also confirmed the distribution of blood vessel networks of arteries, veins, and capillaries in the pleura. Next, we developed a disseminated metastatic mouse tumor model on the pleura of the chest wall and diaphragm. We immuno-stained this model with lymphatic and blood vessel markers. We were able to clearly observe the flowing out lymphatics and flowing in blood vessels of each tumor using a microscope. In this model, each tumor was small, and lymphangiogenesis and angiogenesis from the surrounding vasculatures to the tumor could be identified.

  6. Research on new pleurisy treatments targeting lymphatic vessels

    Kobayashi Makoto

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    Pleural effusion is produced by blood vessels in the pleura and drained from lymphatics, but when the balance is lost, it accumulates. Causes include inflammation and cancer, but current treatments are still poorly managed. There are a few reports of blood vessels such as vascular permeability for effusion, but there are few reports of lymphatics, which are the center of effusion drainage. In this study, we focused on the lymphatics of the pleura and investigated whether they could be therapeutic targets. We created a cancerous pleural effusion model in which lung cancer cells were administered into the thoracic cavity and an inflammatory pleural effusion mouse in which a bacterial toxin was administered. Evaluation of the lymphatics in the pleura of each model revealed dilation of the lymphatic vessel diameter. The cancerous pleural effusion model tended to delay pleural effusion drainage. Lymphangiogenesis inhibitors tended to reduce pleural effusion.

  7. 高齢者における二重課題歩行中の前頭前野脳血流と認知及び運動機能の関係

    森 隆行, 岡崎 達馬, 出江 紳一

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 基盤研究(C)

    Category: 基盤研究(C)

    Institution: 東北大学

    2019 - 2021

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    歩行中に計算などの課題を同時に行う二重課題歩行は、認知及び運動機能のパフォーマンスの低下を引き起こすことが知られており、前頭前野脳血流を測定することで歩行中の注意機能を評価することができる。本研究では二重課題歩行中に近赤外線分光法装置(near-infrared spectroscopy : NIRS)を用い前頭前野脳血流測定と加速度計を用いた歩行解析を行い、脳血流変化と認知及び歩行変動との関連の検討を行うこととした。 2020年度には二重課題歩行中の運動機能と認知機能の研究に関するプロトコルを作成し、東北大学医学系研究科倫理委員会承認を受け、20名の被験者に対して二重課題歩行中の脳血流測定と加速度計の歩行データの取得を完了した。そこで本年度においては、まずこれらのデータ解析を行い、その結果に基づいて新たな計測プロトコールを検討することとしていた。脳血流についての解析では、前頭前野の位置因子とコンディション因子の2元配置分散分析を用い、分散分析の事後検定としてボンフェローニ法で多重比較検定を行い、加速度については、X軸、Y軸、Z軸の値を二乗平均平方根として算出した合計値を求め、各群における平地歩行条件とウォーキングマシーン歩行条件でt検定を行うことを予定していた。

  8. Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5

    Okazaki Tatsuma, Yagita Hideo, Kobayashi Makoto, Tamai Tokiwa, Nihei Mayumi, Tsukita Yoko, Komatsu Riyo

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2014/04/01 - 2017/03/31

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    VEGFR-2 in angiogenesis and VEGFR-3 in lymphangiogenesis are the key players. An anti-DR-5 Ab, the apoptosis inducing antibody, has antitumor effects. Here, we combined anti-DR-5 Ab with VEGFR1-3 inhibitor sunitinib as anti-angiogenic and lymphangiogenic therapies. Mice were injected with 4T1 cells into the footpad and treated with sunitinib and/or anti-DR-5 Ab. The tumors and popliteal lymph nodes were isolated. The growth rate of 4T1 or CT26 tumors was measured. Sunitinib decreased the blood vessel and hypoxic area densities in the tumors, suggesting blood vessel normalization. Sunitinib decreased the amount of tumor injected evans blue and hyaluronic acid in tumors, suggesting better lymphatic flow. The combination increased the ratio of activated dendritic cells and CD8+ T cells in lymph nodes and the numbers of CD8+ and effector CD4+ T cells in tumors compared to controls. The combination decreased the tumor growth rate compared to each mono-therapy.

  9. Intracellular signal analysis of M-CSF-induced lymphangiogenesis stimulating factor VEGF-C,-D production

    KOBAYASHI Makoto, OKAZAKI Tatsuma, NIHEI Mayumi

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

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    Lymphangiogenesis occurs in binding to VEGFR3 mainly expressed in lymphatic vessels of their ligand,VEGF-C or VEGF-D. It has been reported that macrophages and skeletal muscle is source of VEGF-C,-D production. In the present study, we examined wheather M-CSF induce the VECF-C,-D production. VEGF-C, D production induced from mouse macrophages was not observed by administration M-CSF. But in skeletal muscle, diaphragm, and myocardium, we confirmed that the expression levels of VEGF-C,-D were significantly higher.

  10. Exaggerated lymphangiogenesis and remodeled blood vessels in a mouse model and human patients of aspiration pneumonia

    OKAZAKI Tatsuma

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up

    Category: Grant-in-Aid for Research Activity Start-up

    Institution: Tohoku University

    2011 - 2012

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    Previous studies did not show chronic inflammation or vascular changes in aspiration pneumonia or its animal models. We established a mouse model of aspiration pneumonia, and showed chronic inflammation, blood vessel remodeling, and lymphangiogenesis in the model and in patients.

  11. M-CSFによる肺気腫の肺及び呼吸筋再生の研究

    岡崎 達馬

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業 若手研究(B)

    Category: 若手研究(B)

    Institution: 東北大学

    2006 - 2006

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