TOHOKU UNIVERSITY Researchers - Kiyotaka Nakagawa

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Kiyotaka Nakagawa

Section

Graduate School of Agricultural Science

Job title

Professor

Degree

博士（農学）（東北大学）
修士（農学）（東北大学）

researchmap

https://researchmap.jp/read0103828

J-GLOBAL ID

200901037026434814

e-Rad No.

80361145

Profile

脂質をはじめとする食品や生体成分の複雑な酸化情報の精緻化、そしてその理論に基づく制御が研究ライフワークになります。ここから導かれ、基礎と応用が表裏一体となった研究テーマを追求し、食品の未来品質・ヒト健康社会の実現を目指しています。

Research History 8

2016/04 - Present

東北大学大学院農学研究科　教授
2007/04 - 2016/03

東北大学大学院農学研究科　准教授
2013/04 - 2013/10

米国タフツ大学Jean-Mayerヒトの老化と栄養に関する研究所　客員研究員
2004/11 - 2007/03

東北大学大学院農学研究科　助教授
2003/04 - 2004/03

東北大学大学院農学研究科　助手
2000/01 - 2002/12

科学技術振興事業団科学技術特別研究員
1999/04 - 2000/12

日本学術振興会特別研究員（PD）
1998/04 - 1999/03

日本学術振興会特別研究員（DC）

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Education 3

Tohoku University　Graduate School of Agricultural Science

- 1999/03
Tohoku University　Graduate School of Agricultural Science

- 1996/03
Tohoku University　Faculty of Agriculture

- 1994/03

Professional Memberships 20

日本栄養学学術連合
American Oil Chemists' Society
レドックスR&D戦略委員会
日本カロテノイド研究会
油脂・コレステロール研究会
日本酸化ストレス学会
日本脂質栄養学会
日本フードファクター学会
日本食品分析学会
日本分析化学会
日本生化学会
ビタミンE研究会
日本メイラード学会
日本ビタミン学会
日本過酸化脂質・抗酸化物質学会
日本油化学会
日本食品科学工学会
日本脂質生化学会
日本栄養・食糧学会
日本農芸化学会

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Research Interests 5

酸化ストレス
抗酸化
脂質酸化
分析化学
食品化学

Research Areas 2

Life sciences / Food sciences /
Life sciences / Applied biochemistry /

Papers 294

Synthesis of Citrifurans A and D through Assembly of the Natural Products Citrinin and Gregatin A

Yuto Goto, Ayaka Machiya, Taichi Okumura, Yusuke Oka, Junya Ito, Osamu Ishibashi, Yoshihito Shiono, Yasuhiro Meguro, Kiyotaka Nakagawa, Shigefumi Kuwahara, Masaru Enomoto

Organic Letters　2025/07/22

DOI： 10.1021/acs.orglett.5c02665 　
Effects of sodium chloride on the formation of 3-Monochloropropanediol esters in various meats and health risk assessment. International-journal

Hao-Ting Chen, Chui Xuan Tan, Jiun-Rong Chen, Kiyotaka Nakagawa, Shunji Kato, Wei-Ju Lee

Food chemistry: X　29　102754-102754　2025/07

DOI： 10.1016/j.fochx.2025.102754 　

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3-Monochloropropanediol esters (3-MCPDEs) are contaminants formed during high-temperature cooking and oil refining. While meat products are a source of 3-MCPDE exposure, related risk assessments remain limited. This study analyzed 3-MCPDE levels in pan-fried marinated meats (pork, chicken, beef, and salmon, with 0-10 % NaCl) using gas chromatography-mass spectrometry (GC-MS) following American Oil Chemists' Society (AOCS) Cd 29a-13 and assessed exposure in the Taiwanese population. Salt addition and higher unsaturation promoted lipid oxidation, increasing 3-MCPDE formation. Strong correlations (R > 0.9) were found between 3-MCPDE contents and total oxidation (totox) values across different meat types. Pork, with the highest fat content, had the highest 3-MCPDE levels, followed by salmon. Exposure assessments showed 3-MCPDE intake remained below the tolerable daily intake (TDI), with pork being the largest contributor. The highest P95 exposure from four meat types with 10 % NaCl reached 41.35 % of the TDI, suggesting potential risk when combined with other dietary sources.
Dietary Ethanolamine Plasmalogen from Ascidian Alleviates Chronic Hepatic Injury in Mice Treated with Continuous Acetaminophen

Ryosuke Sogame, Yuki Tominaga, Momoka Echigoya, Kiyotaka Nakagawa, Michihiro Fukushima, Teruo Miyazawa, Mikio Kinoshita, Shinji Yamashita

Applied Sciences　2025/05/26

DOI： 10.3390/app15115968 　
MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4. International-journal

Eikan Mishima, Thomas J O'Neill, Kai P Hoefig, Deng Chen, Gesine Behrens, Bernhard Henkelmann, Junya Ito, Kiyotaka Nakagawa, Vigo Heissmeyer, Marcus Conrad, Daniel Krappmann

Proceedings of the National Academy of Sciences of the United States of America　122　(20)　e2507997122　2025/05/20

DOI： 10.1073/pnas.2507997122 　
Effect of microemulsion system on water dispersibility and bioavailability of γ-oryzanol. International-journal

Junya Ito, Naoko Kumagai, Ayaka Suzuki, Naoki Shoji, Isabella Supardi Parida, Mamoru Takahashi, Kiyotaka Nakagawa

Bioscience, biotechnology, and biochemistry　89　(4)　633-637　2025/01/15

DOI： 10.1093/bbb/zbaf002 　

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This study developed water-dispersible γ-oryzanol (WD-OZ) using microemulsion system and assessed their absorption in rats. While γ-oryzanol itself is hardly soluble in water, WD-OZ exhibited high water dispersibility, and γ-oryzanol, along with its metabolites, was detected in rat plasma. These findings provide a solid basis for future application of the microemulsion-based approach to enhance the bioavailability of γ-oryzanol in food.
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis. International-journal

Mike Lange, Michele Wölk, Cody E Doubravsky, Joseph M Hendricks, Shunji Kato, Yurika Otoki, Benjamin Styler, Kiyotaka Nakagawa, Maria Fedorova, James A Olzmann

bioRxiv : the preprint server for biology　2025/01/06

DOI： 10.1101/2025.01.06.631537 　

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Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of LD neutral lipids to peroxidation and protective mechanisms are unknown. Here, we identify LD-localized Ferroptosis Suppressor Protein 1 (FSP1) as a critical regulator that prevents neutral lipid peroxidation by recycling coenzyme Q10 (CoQ10) to its lipophilic antioxidant form. Lipidomics reveal that FSP1 loss leads to the accumulation of oxidized triacylglycerols and cholesteryl esters, and biochemical reconstitution of FSP1 with CoQ10 and NADH suppresses triacylglycerol peroxidation in vitro. Notably, polyunsaturated fatty acid (PUFA)-rich triacylglycerols enhance cancer cell sensitivity to FSP1 loss and inducing PUFA-rich LDs triggers triacylglycerol peroxidation and LD-initiated ferroptosis when FSP1 activity is impaired. These findings uncover the first LD lipid quality control pathway, wherein LD-localized FSP1 maintains neutral lipid integrity to prevent the buildup of oxidized lipids and induction of ferroptosis.
The therapeutic potential of plant-derived flavonoids in neurological disorders through modulation of brain insulin signaling

Isabella Supardi Parida, Halida Rahmania, Kiyotaka Nakagawa

Food Science and Technology Research　31　(2)　75-89　2025
Publisher: Japanese Society for Food Science and Technology
DOI： 10.3136/fstr.fstr-d-24-00202 　

ISSN： 1344-6606

eISSN： 1881-3984
Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria. International-journal

Yusuke Hirata, Yuto Yamada, Soma Taguchi, Ryota Kojima, Haruka Masumoto, Shinnosuke Kimura, Takuya Niijima, Takashi Toyama, Ryoji Kise, Emiko Sato, Yasunori Uchida, Junya Ito, Kiyotaka Nakagawa, Tomohiko Taguchi, Asuka Inoue, Yoshiro Saito, Takuya Noguchi, Atsushi Matsuzawa

Cell death & disease　15　(12)　884-884　2024/12/06

DOI： 10.1038/s41419-024-07237-w 　

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Conjugated fatty acids (CFAs) have been known for their anti-tumor activity. However, the mechanism of action remains unclear. Here, we identify CFAs as inducers of glutathione peroxidase 4 (GPX4) degradation through chaperone-mediated autophagy (CMA). CFAs, such as (10E,12Z)-octadecadienoic acid and α-eleostearic acid (ESA), induced GPX4 degradation, generation of mitochondrial reactive oxygen species (ROS) and lipid peroxides, and ultimately ferroptosis in cancer cell lines, including HT1080 and A549 cells, which were suppressed by either pharmacological blockade of CMA or genetic deletion of LAMP2A, a crucial molecule for CMA. Mitochondrial ROS were sufficient and necessary for CMA-dependent GPX4 degradation. Oral administration of an ESA-rich oil attenuated xenograft tumor growth of wild-type, but not that of LAMP2A-deficient HT1080 cells, accompanied by increased lipid peroxidation, GPX4 degradation and cell death. Our study establishes mitochondria as the key target of CFAs to trigger lipid peroxidation and GPX4 degradation, providing insight into ferroptosis-based cancer therapy.
Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomers. International-journal

Yurika Otoki, Daitaro Ishikawa, Shunji Kato, Ibuki Kusumoto, Yukihiro Ozaki, Kiyotaka Nakagawa

Food chemistry　467　142143-142143　2024/11/27

DOI： 10.1016/j.foodchem.2024.142143 　

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Monitoring oxidation causes (i.e. radical and/or photo-oxidation) of vegetable oil gives very important information for its quality control. This study aimed to develop a rapid and simple near infrared (NIR) spectroscopy method to explore the oxidation causes in vegetable oil by quantifying triacylglycerol hydroperoxide (TGOOH) positional isomers proceeded by different oxidation causes. First, the concentrations of TGOOH isomers were determined by liquid chromatography-mass spectrometry. Partial least square regression for concentrations of TGOOH isomers (R2: 0.994-0.998) using NIR spectra in the regions of 7500-6000 cm-1 and 5500-4500 cm-1 as explanatory variables. Principal component analysis revealed that those models were created because NIR spectra capture trace changes of the peak around 6980 cm-1(-CH2-) and 5260 cm-1 (H2O) derived by different oxidation causes (i.e. radical and/or photo-oxidation). The application of this method to various kinds of vegetable oil is expected to lead to a simple and rapid quality evaluation of vegetable oil.
Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation.

Tokuko Takajo, Koichi Saito, Kazunori Tsuchida, Shunji Kato, Kiyotaka Nakagawa, Akitoshi Okino, Kazunori Anzai

Journal of clinical biochemistry and nutrition　75　(3)　183-189　2024/11

DOI： 10.3164/jcbn.24-72 　

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Liposome lipid peroxidation induced by cold atmospheric pressure plasma jet (CAPPJ) irradiation was investigated. The formation of thiobarbituric acid reactive substances (TBARS), an indicator of lipid peroxidation final products, as a function of irradiation was observed. Lipid radicals, peroxidation reaction intermediates generated by CAPPJ irradiation, were confirmed by increased NBD-pen fluorescence intensity. Additionally, lipid peroxidation products, liposomal phosphatidylcholine (PC) isomers, were analyzed by LC-MS/MS. Products specific to singlet oxygen (1O2) oxidation, 16:0/10-hydroperoxy-8E,12Z-octadecanoic acid (10-8E,12Z-HpODE) PC and 16:0/12-9E,13E-HpODE PC, were not detected, but radical oxidation specific products 16:0/13-9E,11E-HpODE PC and 16:0/9-10E,12E-HpODE PC were. This suggests that during CAPPJ irradiation, radicals, rather than 1O2, are the primary reactive species of lipid peroxidation. This is also supported by the β-carotene quenching of 1O2 not suppressing TBARS and lipid radical generation. Also, neither TBARS formation nor lipid radical generation were suppressed by SOD, indicating that the superoxide radical (O2 •-) is not responsible for the lipid peroxidation reaction. As the CAPPJ irradiation of water produces large quantities of hydroxyl radical (•OH) and •OH scavengers decreased the amount of TBARS produced by CAPPJ irradiation, it is highly plausible that •OH is the primary species involved in CAPPJ-induced liposome lipid peroxidation.
PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

Junya Ito, Toshitaka Nakamura, Takashi Toyama, Deng Chen, Carsten Berndt, Gereon Poschmann, André Santos Dias Mourão, Sebastian Doll, Mirai Suzuki, Weijia Zhang, Jiashuo Zheng, Dietrich Trümbach, Naoya Yamada, Koya Ono, Masana Yazaki, Yasutaka Kawai, Mieko Arisawa, Yusuke Ohsaki, Hitoshi Shirakawa, Adam Wahida, Bettina Proneth, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad

Molecular Cell　2024/11
Publisher: Elsevier BV
DOI： 10.1016/j.molcel.2024.10.028 　

ISSN： 1097-2765
Effects of Different Manufacturing Processes on Thermal and Photo-oxidative Stability of Sesame Oil.

Halida Rahmania, Tomomi Nakanishi, Satomi Oi, Rika Onishi, Eiichiro Yamagami, Kazuyuki Yamane, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

Journal of oleo science　2024/09/20

DOI： 10.5650/jos.ess24084 　

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The roasting process of sesame oil is expected to alter its internal composition and stability under oxidation condition. Presumably, the effect of roasting may differ with oxidation conditions (i.e., thermal and photo-oxidation), but such studies have not been undertaken. To further evaluate this notion, several type of sesame oils (raw and refined as unroasted oil, and roasted oil) and rapeseed oils as comparison were subjected to thermal oxidation (120℃) and photo-oxidation (50,000 lx) for 5 and 10 hours. The result revealed that the roasting sesame oil exhibited good stability under thermal oxidation, possibly due to the change on antioxidant agents such as sesamol and Maillard products during the roasting process. In contrast, the refined sesame oil (unroasted) demonstrated high stability under photo-oxidation, indicating that the refining process has a more significant impact on the oxidative stability in sesame oil compared to the alterations in its components caused by the roasting process. Taken together, this study is the first to show that the roasting and refining processes of sesame oil alter its internal composition and show different variations in sesame oils' oxidative stability under thermal and photo-oxidation, which holds significance considering its global consumption.
Optimisation of acid hydrolysis conditions of choline esters and mass spectrometric determination of total choline in various foods. International-journal

Yoshinari Hirakawa, Kazuhiro Fujita, Masako Katayama, Toshiaki Yokozeki, Yushi Takahashi, Izumi Yoshida, Kiyotaka Nakagawa

Scientific reports　14　(1)　17960-17960　2024/08/02

DOI： 10.1038/s41598-024-69008-z 　

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Determining the content of the nutrient choline in foods and obtaining the required amount from the diet are crucial. One way to measure choline in foods is by converting choline esters to free choline via acid hydrolysis, followed by quantifying the total choline, as adopted by the AOAC method (AOAC-Choline); however, certain choline esters are difficult to hydrolyse. Here, we investigated various acid hydrolysis conditions to establish a reliable method for determining the total choline in foods by detecting free choline using highly sensitive and selective mass spectrometry. Hydrolysis in 0.055 mol/L HCl for 8 h in an autoclave (121 °C) was found to be optimal for the hydrolysis of choline esters in various foods. Twenty-four foods, including grains, seed, vegetables, fruits, mushroom, algae, fish, meats, beverage, processed foods, and egg, were measured. The trends in the total choline content were consistent with previous reports; however, the choline content was 10-20% higher than that measured using AOAC-Choline. Therefore, re-evaluation of the total choline content in foods using our constructed method is recommended. This reassessment will allow for a more reliable determination of choline intake for maintaining health.
1‐Deoxynojirimycin attenuates pathological markers of Alzheimer's disease in the in vitro model of neuronal insulin resistance

Isabella Supardi Parida, Soo Takasu, Junya Ito, Takahiro Eitsuka, Kiyotaka Nakagawa

The FASEB Journal　38　(13)　2024/07/09
Publisher: Wiley
DOI： 10.1096/fj.202302600r 　

ISSN： 0892-6638

eISSN： 1530-6860

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Abstract Insulin resistance, the hallmark of type 2 diabetes mellitus (T2DM), has emerged as a pathological feature in Alzheimer's disease (AD). Given the shared role of insulin resistance in T2DM and AD, repurposing peripheral insulin sensitizers is a promising strategy to preserve neuronal insulin sensitivity and prevent AD. 1‐Deoxynojirimycin (DNJ), a bioactive iminosugar, exhibited insulin‐sensitizing effects in metabolic tissues and was detected in brain tissue post‐oral intake. However, its impact on brain and neuronal insulin signaling has not been described. Here, we investigated the effect of DNJ treatment on insulin signaling and AD markers in insulin‐resistant human SK‐N‐SH neuroblastoma, a cellular model of neuronal insulin resistance. Our findings show that DNJ increased the expression of insulin signaling genes and the phosphorylation status of key molecules implicated in insulin resistance (Y1146‐pIRβ, S473‐pAKT, S9‐GSK3B) while also elevating the expression of glucose transporters Glut3 and Glut4, resulting in higher glucose uptake upon insulin stimuli. DNJ appeared to mitigate the insulin resistance‐driven increase in phosphorylated tau and Aβ_1‐42 levels by promoting insulin‐induced phosphorylation of GSK3B (a major tau kinase) and enhancing mRNA expression of the insulin‐degrading enzyme (IDE) pivotal for insulin and Aβ clearance. Overall, our study unveils probable mechanisms underlying the potential benefits of DNJ for AD, wherein DNJ attenuates tau and amyloid pathologies by reversing neuronal insulin resistance. This provides a scientific basis for expanding the use of DNJ‐containing products for neuroprotective purposes and prompts further research into compounds with similar mechanisms of action.
Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products - 2-alkanones and lactones. International-journal

Kanji Aoyagi, Shunji Kato, Daisuke Isaka, Yoshinori Sekiguchi, Yurika Otoki, Hidetaka Uehara, Kiyotaka Nakagawa

Food chemistry: X　21　101074-101074　2024/03/30

DOI： 10.1016/j.fochx.2023.101074 　

eISSN： 2590-1575
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis. International-journal

Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-Ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi

Nature communications　15　(1)　2195-2195　2024/03/12

DOI： 10.1038/s41467-024-46386-6 　

eISSN： 2041-1723
Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts. International-journal

Chikara Kato, Ibuki Kusumoto, Shunji Kato, Yurika Otoki, Junya Ito, Hirono Totsuka, Arun Rajgopal, Jina Hong, Kiyotaka Nakagawa

Biochemical and biophysical research communications　698　149553-149553　2024/02/26

DOI： 10.1016/j.bbrc.2024.149553 　

ISSN： 0006-291X

eISSN： 1090-2104
A tangible method to assess native ferroptosis suppressor activity. International-journal

Toshitaka Nakamura, Junya Ito, André Santos Dias Mourão, Adam Wahida, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad

Cell reports methods　4　(3)　100710-100710　2024/02/24

DOI： 10.1016/j.crmeth.2024.100710 　

eISSN： 2667-2375
Identification of Genes Associated with Resistance to Persulcatusin, a Tick Defensin from Ixodes persulcatus. International-journal

So Shimoda, Junya Ito, Tasuke Ando, Ryuta Tobe, Kiyotaka Nakagawa, Hiroshi Yoneyama

Microorganisms　12　(2)　2024/02/19

DOI： 10.3390/microorganisms12020412 　

eISSN： 2076-2607
LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation International-journal

Hirotada Saito, Shunji Kato, Naoki Shimizu, Takumi Takahashi, Mirinthorn Jutanom, Junya Ito, Satoshi Kasatani, Kiyotaka Nakagawa

Food Research International　178　113913-113913　2024/02

DOI： 10.1016/j.foodres.2023.113913 　

ISSN： 0963-9969

eISSN： 1873-7145
Higher Cholesterol Absorption Marker at Baseline Predicts Fewer Cardiovascular Events in Elderly Patients Receiving Hypercholesterolemia Treatment: The KEEP Study. International-journal

Masanari Kuwabara, Jun Sasaki, Yasuyoshi Ouchi, Shinichi Oikawa, Kiyotaka Nakagawa, Masao Sato, Shinji Koba, Suminori Kono, Tetsunori Saikawa, Hidenori Arai

Journal of the American Heart Association　13　(3)　e031865　2024/01/19

DOI： 10.1161/JAHA.123.031865 　

eISSN： 2047-9980
Comparison of the Catabolic Rates of Linoleic and Oleic Acid Hydroperoxides Using 13CO2 Expired from Mice.

Aya Yoshinaga-Kiriake, Kazuaki Yoshinaga, Sae Miyagawa, Kanako Yoshino, Seiya Tanaka, Takumi Takahashi, Shunji Kato, Junya Ito, Yurika Otoki, Kiyotaka Nakagawa, Naohiro Gotoh

Journal of oleo science　73　(6)　847-855　2024

DOI： 10.5650/jos.ess23236 　

ISSN： 1345-8957

eISSN： 1347-3352
Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models. International-journal

Mirinthorn Jutanom, Shunji Kato, Shinji Yamashita, Masako Toda, Mikio Kinoshita, Kiyotaka Nakagawa

Scientific reports　13　(1)　22537-22537　2023/12/18

DOI： 10.1038/s41598-023-49521-3 　

eISSN： 2045-2322
Unveiling an unexpected superoxide-mediated photooxidation mechanism of squalene monohydroperoxides to squalene hydroperoxy cyclic peroxides through ESR and LC–MS/MS analyses International-journal

Saoussane Khalifa, Masaru Enomoto, Kiyotaka Nakagawa

Scientific Reports　13　(1)　19525-19525　2023/11/09
Publisher: Springer Science and Business Media LLC
DOI： 10.1038/s41598-023-46044-9 　

eISSN： 2045-2322
Sheep-derived cell immortalization through the expression of cell cycle regulators and biological characterization using transcriptomes. International-journal

Noe Kikuchi, Himari Matsusaka, Lanlan Bai, Hiroaki Sano, Takahiro Eitsuka, Kiyotaka Nakagawa, Eriko Sugano, Taku Ozaki, Hiroshi Tomita, Tohru Kiyono, Tomokazu Fukuda

Cell biology international　47　(9)　1491-1501　2023/09

DOI： 10.1002/cbin.12034 　

ISSN： 1065-6995

eISSN： 1095-8355
The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin. International-journal

Takashi Nakatomi, Mayuko Itaya-Takahashi, Yosuke Horikoshi, Naoki Shimizu, Isabella Supardi Parida, Mirinthorn Jutanom, Takahiro Eitsuka, Yoshikazu Tanaka, Jean-Marc Zingg, Tatsuya Matsura, Kiyotaka Nakagawa

Scientific reports　13　(1)　7392-7392　2023/05/06

DOI： 10.1038/s41598-023-34584-z 　

eISSN： 2045-2322
Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease. International-journal

Yurika Otoki, Di Yu, Qing Shen, Demetrios J Sahlas, Joel Ramirez, Fuqiang Gao, Mario Masellis, Richard H Swartz, Pak Cheung Chan, Jacqueline A Pettersen, Shunji Kato, Kiyotaka Nakagawa, Sandra E Black, Walter Swardfager, Ameer Y Taha

Journal of Alzheimer's disease : JAD　93　(2)　665-682　2023/04/17

DOI： 10.3233/JAD-220795 　

eISSN： 1875-8908
Immortalization of primary cells derived from the endangered Ryukyu long-furred rat International-journal

Lanlan Bai, Noe Kikuchi, Takahiro Eitsuka, Himari Matsusaka, Kiyotaka Nakagawa, Masafumi Katayama, Keiko Ito, Miho Inoue-Murayama, Tohru Kiyono, Tomkazu Fukuda

In Vitro Cellular & Developmental Biology - Animal　59　(3)　234-234　2023/03/27
Publisher: Springer Science and Business Media LLC
DOI： 10.1007/s11626-023-00757-3 　

ISSN： 1071-2690

eISSN： 1543-706X

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The Ryukyu long-furred rat is an endangered species confined to the southernmost three small islands of Japan (Amami-Oshima, Tokunoshima, and Okinawa). Its population is rapidly decreasing because of roadkill, deforestation, and feral animals. To date, its genomic and biological information are poorly understood. In this study, we successfully immortalized Ryukyu long-furred rat cells by expressing a combination of cell cycle regulators, mutant cyclin-dependent kinase 4 (CDK4R24C) and cyclin D1, together with telomerase reverse transcriptase or an oncogenic protein, the Simian Virus large T antigen. The cell cycle distribution, telomerase enzymatic activity, and karyotype of these two immortalized cell lines were analyzed. The karyotype of the former cell line immortalized with cell cycle regulators and telomerase reverse transcriptase retained the nature of the primary cells, while that of the latter cell line immortalized with the Simian Virus large T antigen had many aberrant chromosomes. These immortalized cells would be valuable for studying the genomics and biology of Ryukyu long-furred rats.
Effects of Particle Size of Curcumin Solid Dispersions on Bioavailability and Anti-Inflammatory Activities. International-journal

Chihiro Kato, Mayuko Itaya-Takahashi, Taiki Miyazawa, Junya Ito, Isabella Supardi Parida, Hiroki Yamada, Akari Abe, Mika Shibata, Keita Someya, Kiyotaka Nakagawa

Antioxidants (Basel, Switzerland)　12　(3)　2023/03/15

DOI： 10.3390/antiox12030724 　

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The delivery of curcumin (CUR) using the solid dispersion system (CUR solid dispersions; C-SDs) has been shown to improve CUR bioavailability. However, it is unclear how different particle sizes of C-SDs affect the bioavailability and biological activities of CUR. Hence, we prepared C-SDs in different sizes using food-grade excipients and evaluated their bioavailability and biological activities. By pulverizing large particle sizes of C-SDs using zirconia beads, we successfully prepared C-SDs I-IV (particle size: (I) 120, (II) 447, (III) 987, (IV) 1910 nm). When administrated orally in rats, the bioavailability of CUR was increased with decreasing C-SDs size, most likely by improving its solubility in micelles. When administrated intravenously in rats, blood concentrations of CUR were increased with increasing particle size, suggesting that larger C-SDs presumably control the metabolic conversion of CUR. In RAW264 cells, more CUR was taken up by cells as their sizes reduced, and the more potent their anti-inflammatory activities were, suggesting that smaller C-SDs were taken up through a number of cellular uptake pathways. Altogether, the present study showed an evident effect of C-SDs size on their bioavailability and anti-inflammatory activities-information that serves as a basis for improving the functionality of CUR.
コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響

渡辺章夫, 加藤毅, 衛藤未侑, 小林亘, 倉若美咲樹, 三嶋隆, 仲川清隆

十文字学園女子大学紀要　53　29-36　2023/03
Immortalization of primary cells derived from the endangered Ryukyu long-furred rat

Lanlan Bai, Noe Kikuchi, Takahiro Eitsuka, Himari Matsusaka, Kiyotaka Nakagawa, Masafumi Katayama, Keiko Ito, Miho Inoue-Murayama, Tohru Kiyono, Tomokazu Fukuda

In Vitro Cellular and Developmental Biology - Animal　59　(3)　224-233　2023/03

DOI： 10.1007/s11626-023-00757-3 　

ISSN： 1071-2690

eISSN： 1543-706X
ホヤ由来エタノールアミン型プラズマローゲンの認知機能に対する有効性及び安全性評価プラセボ対照ランダム化二重盲検並行群間比較

山本采佳, 相澤光輝, 久保村大樹, 赤堀雄介, 山下慎司, 仲川清隆, 宮澤陽夫

応用薬理　104　(1-2)　17-24　2023/03
Publisher: 応用薬理研究会
ISSN： 0300-8533
Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity. International-journal

Yuki Taya, Mari Mizunaga, Shunsuke Nakao, Mirinthorn Jutanom, Naoki Shimizu, Yukihiro Nomura, Kiyotaka Nakagawa

Molecules (Basel, Switzerland)　28　(4)　2023/02/07

DOI： 10.3390/molecules28041576 　

eISSN： 1420-3049
Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography-mass spectrometry. International-journal

Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

Scientific reports　13　(1)　1325-1325　2023/01/24

DOI： 10.1038/s41598-023-28514-2 　

eISSN： 2045-2322
Cellular Uptake of Pyrroloquinoline Quinone in Its Intact and Derivatized Forms from the Cell Culture Medium of 3T3-L1.

Chikara Kato, Isabella Supardi Parida, Satoshi Maeda, Tsuyoshi Mikekado, Shunji Kato, Susumu Takekoshi, Kiyotaka Nakagawa

Journal of oleo science　71　(12)　1761-1767　2022/12/03

DOI： 10.5650/jos.ess22284 　

ISSN： 1345-8957

eISSN： 1347-3352
Elucidation of decomposition pathways of linoleic acid hydroperoxide isomers by GC-MS and LC-MS/MS. International-journal

Ruriko Miyazaki, Shunji Kato, Yurika Otoki, Halida Rahmania, Masayoshi Sakaino, Shigeo Takeuchi, Toshiro Sato, Jun Imagi, Kiyotaka Nakagawa

Bioscience, biotechnology, and biochemistry　87　(2)　179-190　2022/11/23

DOI： 10.1093/bbb/zbac189 　

ISSN： 0916-8451

eISSN： 1347-6947
Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to Ferroptosis.

Chikara Kato, Yuuri Suzuki, Isabella Supardi Parida, Shunji Kato, Hiroyuki Yamasaki, Susumu Takekoshi, Kiyotaka Nakagawa

Journal of oleo science　71　(11)　1689-1694　2022/10/28

DOI： 10.5650/jos.ess22281 　

ISSN： 1345-8957

eISSN： 1347-3352
Structural Analysis and Anti-Inflammatory Effect of a Digalactosyldiacylglycerol-Monoestolide, a Characteristic Glycolipid in Oats. International-journal

Hiroki Yamada, Junya Ito, Naoki Shimizu, Takumi Takahashi, Chikara Kato, Isabella Supardi Parida, Mirinthorn Jutanom, Katsuyuki Ishihara, Kiyotaka Nakagawa

Nutrients　14　(19)　2022/10/06

DOI： 10.3390/nu14194153 　

eISSN： 2072-6643
Coprinopsis cinerea dioxygenase is an oxygenase forming 10(S)-hydroperoxide of linoleic acid, essential for mushroom alcohol, 1-octen-3-ol synthesis. International-journal

Takuya Teshima, Risa Funai, Takehito Nakazawa, Junya Ito, Toshihiko Utsumi, Pattana Kakumyan, Hiromi Mukai, Toyoshi Yoshiga, Ryutaro Murakami, Kiyotaka Nakagawa, Yoichi Honda, Kenji Matsui

The Journal of biological chemistry　298　(11)　102507-102507　2022/09/16

DOI： 10.1016/j.jbc.2022.102507 　

ISSN： 0021-9258

eISSN： 1083-351X
Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract. International-journal

Takumi Takahashi, Shunji Kato, Junya Ito, Naoki Shimizu, Isabella Supardi Parida, Mayuko Itaya-Takahashi, Masayoshi Sakaino, Jun Imagi, Kazuaki Yoshinaga, Aya Yoshinaga-Kiriake, Naohiro Gotoh, Ikuo Ikeda, Kiyotaka Nakagawa

Redox biology　57　102471-102471　2022/09/14

DOI： 10.1016/j.redox.2022.102471 　

ISSN： 2213-2317
Elucidation of Olive Oil Oxidation Mechanisms by Analysis of Triacylglycerol Hydroperoxide Isomers Using LC-MS/MS. International-journal

Hayato Takahashi, Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Jun Imagi, Kiyotaka Nakagawa

Molecules (Basel, Switzerland)　27　(16)　2022/08/18

DOI： 10.3390/molecules27165282 　

eISSN： 1420-3049
A non-canonical vitamin K cycle is a potent ferroptosis suppressor. International-journal

Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A Pratt, Marcus Conrad

Nature　608　(7924)　778-783　2022/08/03

DOI： 10.1038/s41586-022-05022-3 　

ISSN： 0028-0836

eISSN： 1476-4687
Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils. International-journal

Masayoshi Sakaino, Takashi Sano, Shunji Kato, Naoki Shimizu, Junya Ito, Halida Rahmania, Jun Imagi, Kiyotaka Nakagawa

Scientific reports　12　(1)　12460-12460　2022/07/21

DOI： 10.1038/s41598-022-15627-3 　

eISSN： 2045-2322
Improving water dispersibility and bioavailability of luteolin using microemulsion system. International-journal

Ayaka Miyashita, Junya Ito, Isabella Supardi Parida, Naoki Syoji, Tomoyuki Fujii, Hidehiro Takahashi, Kiyotaka Nakagawa

Scientific reports　12　(1)　11949-11949　2022/07/13

DOI： 10.1038/s41598-022-16220-4 　

eISSN： 2045-2322
Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon. International-journal

Ai Orimoto, Haruka Shinohara, Takahiro Eitsuka, Kiyotaka Nakagawa, Erika Sasaki, Tohru Kiyono, Tomokazu Fukuda

Tissue & cell　77　101848-101848　2022/06/02

DOI： 10.1016/j.tice.2022.101848 　

ISSN： 0040-8166

eISSN： 1532-3072
Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells. International-journal

Keiko Tamiya-Koizumi, Yurika Otoki, Kiyotaka Nakagawa, Reiji Kannagi, Naoki Mizutani, Motoshi Suzuki, Mamoru Kyogashima, Soichiro Iwaki, Mineyoshi Aoyama, Takashi Murate, Kazuyuki Kitatani, Takahisa Kuga, Yasuyoshi Mizutani, Akira Tokumura

Biochemical and biophysical research communications　611　1-7　2022/04/15

DOI： 10.1016/j.bbrc.2022.04.061 　

ISSN： 0006-291X

eISSN： 1090-2104
Determination of acrolein generation pathways from linoleic acid and linolenic acid: increment by photo irradiation. International-journal

Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Shigeo Takeuchi, Jun Imagi, Kiyotaka Nakagawa

NPJ science of food　6　(1)　21-21　2022/04/12

DOI： 10.1038/s41538-022-00138-2 　

eISSN： 2396-8370
Total Synthesis of the Broad-Spectrum Antibiotic Amycolamicin. International-journal

Yasuhiro Meguro, Junya Ito, Kiyotaka Nakagawa, Shigefumi Kuwahara

Journal of the American Chemical Society　144　(12)　5253-5257　2022/03/30

DOI： 10.1021/jacs.2c00647 　

ISSN： 0002-7863

eISSN： 1520-5126
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage. International-journal Peer-reviewed

Jeremy P Koelmel, Wan Y Tan, Yang Li, John A Bowden, Atiye Ahmadireskety, Andrew C Patt, David J Orlicky, Ewy Mathé, Nicholas M Kroeger, David C Thompson, Jason A Cochran, Jaya Prakash Golla, Aikaterini Kandyliari, Ying Chen, Georgia Charkoftaki, Joy D Guingab-Cagmat, Hiroshi Tsugawa, Anmol Arora, Kirill Veselkov, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Richard A Yost, Timothy J Garrett, Vasilis Vasiliou

Hepatology communications　6　(3)　513-525　2022/03

DOI： 10.1002/hep4.1825 　

eISSN： 2471-254X
The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake International-journal Peer-reviewed

Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa

Food and Function　13　(2)　639-648　2022/01/21

DOI： 10.1039/d1fo03234h 　

ISSN： 2042-6496

eISSN： 2042-650X
Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity: Via enzymatic degradation of GAL-DNJ to DNJ International-journal Peer-reviewed

Soo Takasu, Isabella Supardi Parida, Yoshihiro Kojima, Toshiyuki Kimura, Kiyotaka Nakagawa

Food and Function　12　(24)　12250-12255　2021/12/21

DOI： 10.1039/d1fo02307a 　

ISSN： 2042-6496

eISSN： 2042-650X
Dietary Ethanolamine Plasmalogen Alleviates DSS-Induced Colitis by Enhancing Colon Mucosa Integrity, Antioxidative Stress, and Anti-inflammatory Responses via Increased Ethanolamine Plasmalogen Molecular Species: Protective Role of Vinyl Ether Linkages International-journal Peer-reviewed

Ephantus Nguma, Shinji Yamashita, Kyu Ho Han, Yurika Otoki, Ayaka Yamamoto, Kiyotaka Nakagawa, Michihiro Fukushima, Teruo Miyazawa, Mikio Kinoshita

Journal of Agricultural and Food Chemistry　69　(44)　13034-13044　2021/11/10

DOI： 10.1021/acs.jafc.1c04420 　

ISSN： 0021-8561

eISSN： 1520-5118
Differences in bioavailability and tissue accumulation efficiency of (all-E)- and (Z)-carotenoids: A comparative study International-journal Peer-reviewed

Masaki Honda, Soo Takasu, Kiyotaka Nakagawa, Takanori Tsuda

Food Chemistry　361　130119-130119　2021/11/01

DOI： 10.1016/j.foodchem.2021.130119 　

ISSN： 0308-8146

eISSN： 1873-7072
Novel photoinduced squalene cyclic peroxide identified, detected, and quantified in human skin surface lipids International-journal Peer-reviewed

Saoussane Khalifa, Masaru Enomoto, Shunji Kato, Kiyotaka Nakagawa

Antioxidants　10　(11)　2021/11

DOI： 10.3390/antiox10111760 　

eISSN： 2076-3921
A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ. International-journal Peer-reviewed

Isabella Supardi Parida, Soo Takasu, Kiyotaka Nakagawa

Critical reviews in food science and nutrition　63　(19)　1-29　2021/10/16

DOI： 10.1080/10408398.2021.1989660 　

ISSN： 1040-8398

eISSN： 1549-7852
Investigation of lipoproteins oxidation mechanisms by the analysis of lipid hydroperoxide isomers International-journal Peer-reviewed

Shunji Kato, Yusuke Osuka, Saoussane Khalifa, Takashi Obama, Hiroyuki Itabe, Kiyotaka Nakagawa

Antioxidants　10　(10)　2021/10

DOI： 10.3390/antiox10101598 　

eISSN： 2076-3921
Linoleic acid and squalene are oxidized by discrete oxidation mechanisms in human sebum. International-journal Peer-reviewed

Ayano Ishikawa, Junya Ito, Naoki Shimizu, Shunji Kato, Eri Kobayashi, Hiroki Ohnari, Osamu Sakata, Eiji Naru, Kiyotaka Nakagawa

Annals of the New York Academy of Sciences　1500　(1)　112-121　2021/09

DOI： 10.1111/nyas.14615 　

ISSN： 0077-8923

eISSN： 1749-6632
Structural Analysis of Lipid Hydroperoxides Using Mass Spectrometry with Alkali Metals. International-journal Peer-reviewed

Shunji Kato, Naoki Shimizu, Yusuke Ogura, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Shigefumi Kuwahara, Susumu Takekoshi, Jun Imagi, Kiyotaka Nakagawa

Journal of the American Society for Mass Spectrometry　32　(9)　2399-2409　2021/09/01

DOI： 10.1021/jasms.1c00039 　

ISSN： 1044-0305

eISSN： 1879-1123
A Novel Technique for Redox Lipidomics Using Mass Spectrometry: Application on Vegetable Oils Used to Fry Potatoes. International-journal Peer-reviewed

Jeremy P Koelmel, Juan J Aristizabal-Henao, Zhixu Ni, Maria Fedorova, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa, Elizabeth Z Lin, Krystal J Godri Pollitt, Vasilis Vasiliou, Joy D Guingab, Timothy J Garrett, Traycie L Williams, John A Bowden, Meera Penumetcha

Journal of the American Society for Mass Spectrometry　32　(7)　1798-1809　2021/07/07

DOI： 10.1021/jasms.1c00150 　

ISSN： 1044-0305

eISSN： 1879-1123
Synthesis of a plasmenylethanolamine. International-journal Peer-reviewed

Satoshi Maeda, Tomoyo Mohri, Tsubasa Inoue, Yoshio Asano, Yurika Otoki, Masaru Enomoto, Kiyotaka Nakagawa, Shigefumi Kuwahara, Yusuke Ogura

Bioscience, biotechnology, and biochemistry　85　(6)　1383-1389　2021/03/11

DOI： 10.1093/bbb/zbab037 　

ISSN： 0916-8451

eISSN： 1347-6947
Differences in the Compositions of Vitamin E Tocochromanol (Tocopherol and Tocotrienol) in Rice Bran Oils Produced in Japan and Other Countries. Peer-reviewed

Yasushi Endo, Kiyotaka Nakagawa

Journal of oleo science　70　(4)　503-507　2021/03/10

DOI： 10.5650/jos.ess20277 　

ISSN： 1345-8957

eISSN： 1347-3352
Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage. International-journal Peer-reviewed

Ephantus Nguma, Yuki Tominaga, Shinji Yamashita, Yurika Otoki, Ayaka Yamamoto, Kiyotaka Nakagawa, Teruo Miyazawa, Mikio Kinoshita

Lipids　56　(2)　167-180　2021/03

DOI： 10.1002/lipd.12283 　

ISSN： 0024-4201

eISSN： 1558-9307
Lipidomic Analysis of Postmortem Prefrontal Cortex Phospholipids Reveals Changes in Choline Plasmalogen Containing Docosahexaenoic Acid and Stearic Acid Between Cases With and Without Alzheimer's Disease. International-journal Peer-reviewed

Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa, Danielle J Harvey, Lee-Way Jin, Britany N Dugger, Ameer Y Taha

Neuromolecular medicine　23　(1)　161-175　2021/03

DOI： 10.1007/s12017-020-08636-w 　

ISSN： 1535-1084

eISSN： 1559-1174
Ethanolamine Plasmalogen Suppresses Apoptosis in Human Intestinal Tract Cells in Vitro by Attenuating Induced Inflammatory Stress. International-journal Peer-reviewed

Ephantus Nguma, Shinji Yamashita, Kei Kumagai, Yurika Otoki, Ayaka Yamamoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Teruo Miyazawa, Mikio Kinoshita

ACS omega　6　(4)　3140-3148　2021/02/02

DOI： 10.1021/acsomega.0c05545 　

eISSN： 2470-1343
Isolation and structural elucidation of unique γ-oryzanol species in rice bran oil. International-journal Peer-reviewed

Kazue Sawada, Takuya Nakagami, Halida Rahmania, Midori Matsuki, Junya Ito, Tomoyo Mohri, Yusuke Ogura, Shigefumi Kuwahara, Hiroyuki Hashimoto, Kiyotaka Nakagawa

Food chemistry　337　127956-127956　2021/02/01

DOI： 10.1016/j.foodchem.2020.127956 　

ISSN： 0308-8146

eISSN： 1873-7072
Absorption Kinetics of Ethanolamine Plasmalogen and Its Hydrolysate in Mice. Peer-reviewed

Shinji Yamashita, Kazufumi Fujiwara, Yuki Tominaga, Ephantus Nguma, Takumi Takahashi, Yurika Otoki, Ayaka Yamamoto, Ohki Higuchi, Kiyotaka Nakagawa, Mikio Kinoshita, Teruo Miyazawa

Journal of oleo science　70　(2)　263-273　2021/02/01

DOI： 10.5650/jos.ess20223 　

ISSN： 1345-8957

eISSN： 1347-3352
A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology. International-journal Peer-reviewed

Taiki Miyazawa, Mayuko Itaya, Gregor C Burdeos, Kiyotaka Nakagawa, Teruo Miyazawa

International journal of nanomedicine　16　3937-3999　2021

DOI： 10.2147/IJN.S298606 　

ISSN： 1176-9114

eISSN： 1178-2013
Structural changes of ethanolamine plasmalogen during intestinal absorption. International-journal

Takumi Takahashi, Reina Kamiyoshihara, Yurika Otoki, Junya Ito, Shunji Kato, Takuji Suzuki, Shinji Yamashita, Takahiro Eitsuka, Ikuo Ikeda, Kiyotaka Nakagawa

Food & function　11　(9)　8068-8076　2020/09/23

DOI： 10.1039/d0fo01666g 　

ISSN： 2042-6496

eISSN： 2042-650X
Effects of Sphingolipid Fractions from Golden Oyster Mushroom (Pleurotus citrinopileatus) on Apoptosis Induced by Inflammatory Stress in an Intestinal Tract in vitro Model.

Mirinthorn Jutanom, Chisato Higaki, Shinji Yamashita, Kiyotaka Nakagawa, Satoshi Matsumoto, Mikio Kinoshita

Journal of oleo science　69　(9)　1087-1093　2020/09/02

DOI： 10.5650/jos.ess20105 　

ISSN： 1345-8957

eISSN： 1347-3352
Characterization of newly developed pepper cultivars (Capsicum chinense) 'Dieta0011-0301', 'Dieta0011-0602', 'Dieta0041-0401', and 'Dieta0041-0601' containing high capsinoid concentrations and a strong fruity aroma. International-journal

Tetsuya Seki, Masafumi Ota, Hiroto Hirano, Kiyotaka Nakagawa

Bioscience, biotechnology, and biochemistry　84　(9)　1870-1885　2020/09

DOI： 10.1080/09168451.2020.1771168 　

ISSN： 0916-8451

eISSN： 1347-6947
Revealing the thermal oxidation stability and its mechanism of rice bran oil International-journal

Halida Rahmania, Shunji Kato, Kazue Sawada, Chieko Hayashi, Hiroyuki Hashimoto, Shigeo Nakajima, Yurika Otoki, Junya Ito, Kiyotaka Nakagawa

SCIENTIFIC REPORTS　10　(1)　14091-14091　2020/08

DOI： 10.1038/s41598-020-71020-y 　

ISSN： 2045-2322

eISSN： 2045-2322
Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters. International-journal

Soo Takasu, Isabella S Parida, Junya Ito, Yoshihiro Kojima, Takahiro Eitsuka, Toshiyuki Kimura, Kiyotaka Nakagawa

Journal of agricultural and food chemistry　68　(24)　6656-6663　2020/06/17

DOI： 10.1021/acs.jafc.0c03005 　

ISSN： 0021-8561

eISSN： 1520-5118
Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1. International-journal Peer-reviewed

Ai Orimoto, Masafumi Katayama, Tetsuya Tani, Keiko Ito, Takahiro Eitsuka, Kiyotaka Nakagawa, Miho Inoue-Murayama, Manabu Onuma, Tohru Kiyono, Tomokazu Fukuda

Biochemical and biophysical research communications　525　(4)　1046-1053　2020/05/14

DOI： 10.1016/j.bbrc.2020.03.036 　

ISSN： 0006-291X

eISSN： 1090-2104
Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue. International-journal

Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka, Kiyotaka Nakagawa

Food & function　11　(5)　3926-3940　2020/05/01

DOI： 10.1039/d0fo00271b 　

ISSN： 2042-6496

eISSN： 2042-650X
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. International-journal Peer-reviewed

Naoya Yamada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata, Shuntaro Hara, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata, Masafumi Takahashi

Cell death & disease　11　(2)　144-144　2020/02/24

DOI： 10.1038/s41419-020-2334-2 　

eISSN： 2041-4889
Analysis of oxidation products of α-tocopherol in extra virgin olive oil using liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

Rena Tanno, Shunji Kato, Naoki Shimizu, Junya Ito, Shuntaro Sato, Yusuke Ogura, Masayoshi Sakaino, Takashi Sano, Takahiro Eitsuka, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

Food chemistry　306　125582-125582　2020/02/15

DOI： 10.1016/j.foodchem.2019.125582 　

ISSN： 0308-8146

eISSN： 1873-7072
Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers. International-journal Peer-reviewed

Eikan Mishima, Emiko Sato, Junya Ito, Ken-Ichi Yamada, Chitose Suzuki, Yoshitsugu Oikawa, Tetsuro Matsuhashi, Koichi Kikuchi, Takafumi Toyohara, Takehiro Suzuki, Sadayoshi Ito, Kiyotaka Nakagawa, Takaaki Abe

Journal of the American Society of Nephrology : JASN　31　(2)　280-296　2020/02

DOI： 10.1681/ASN.2019060570 　

ISSN： 1046-6673

eISSN： 1533-3450
Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice International-journal Peer-reviewed

Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure

PLOS GENETICS　16　(2)　e1008628　2020/02

DOI： 10.1371/journal.pgen.1008628 　

ISSN： 1553-7404

eISSN： 1553-7404
Direct Separation of the Diastereomers of Cholesterol Ester Hydroperoxide Using LC-MS/MS to Evaluate Enzymatic Lipid Oxidation.

Junya Ito, Naoki Shimizu, Shunji Kato, Yusuke Ogura, Kiyotaka Nakagawa

Symmetry　12　(7)　1127-1127　2020

DOI： 10.3390/sym12071127 　

eISSN： 2073-8994
Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor. International-journal

Tomokazu Fukuda, Kouhei Takahashi, Shin Takase, Ai Orimoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Tohru Kiyono

Frontiers in cell and developmental biology　8　157-157　2020

DOI： 10.3389/fcell.2020.00157 　

eISSN： 2296-634X
Oxytocin Ameliorates Impaired Behaviors of High Fat Diet-Induced Obese Mice. International-journal

Ryotaro Hayashi, Yoshiyuki Kasahara, Shizu Hidema, Satoshi Fukumitsu, Kiyotaka Nakagawa, Katsuhiko Nishimori

Frontiers in endocrinology　11　379-379　2020

DOI： 10.3389/fendo.2020.00379 　

eISSN： 1664-2392
Kinetic Study of Singlet-Oxygen Quenching and Aroxyl-Radical Scavenging Activities of Vitamin E Homologs and Fatty Acids Present in Vegetable Oils. Peer-reviewed

Kazuo Mukai, Masayuki Hirata, Junya Ito, Taiki Shiomi, Kiyotaka Nakagawa, Shin-Ichi Nagaoka

Journal of oleo science　69　(1)　7-22　2020

DOI： 10.5650/jos.ess19217 　

ISSN： 1345-8957

eISSN： 1347-3352
Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition. International-journal Peer-reviewed

Ai Orimoto, Seiko Kyakumoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda

PloS one　15　(3)　e0229996　2020

DOI： 10.1371/journal.pone.0229996 　

eISSN： 1932-6203
Randomized controlled trial of a water-soluble formulation of lutein in humans. International-journal Peer-reviewed

Junya Kobayashi, Etsuko Tominaga, Makoto Ozeki, Tsutomu Okubo, Kiyotaka Nakagawa, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　83　(12)　2372-2374　2019/12

DOI： 10.1080/09168451.2019.1649977 　

ISSN： 0916-8451

eISSN： 1347-6947
Evaluation of squalene oxidation mechanisms in human skin surface lipids and shark liver oil supplements. International-journal Peer-reviewed

Naoki Shimizu, Junya Ito, Shunji Kato, Takahiro Eitsuka, Tetsuo Saito, Hiroshi Nishida, Teruo Miyazawa, Kiyotaka Nakagawa

Annals of the New York Academy of Sciences　1457　(1)　158-165　2019/12

DOI： 10.1111/nyas.14219 　

ISSN： 0077-8923

eISSN： 1749-6632
Definitive evidence of the presence of 24-methylenecycloartanyl ferulate and 24-methylenecycloartanyl caffeate in barley. International-journal Peer-reviewed

Junya Ito, Kazue Sawada, Yusuke Ogura, Fan Xinyi, Halida Rahmania, Tomoyo Mohri, Noriko Kohyama, Eunsang Kwon, Takahiro Eitsuka, Hiroyuki Hashimoto, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　9　(1)　12572-12572　2019/08/29

DOI： 10.1038/s41598-019-48985-6 　

eISSN： 2045-2322
The differential cellular uptake of curcuminoids in vitro depends dominantly on albumin interaction. International-journal Peer-reviewed

Mayuko Itaya, Taiki Miyazawa, Jean-Marc Zingg, Takahiro Eitsuka, Angelo Azzi, Mohsen Meydani, Teruo Miyazawa, Kiyotaka Nakagawa

Phytomedicine : international journal of phytotherapy and phytopharmacology　59　152902-152902　2019/06

DOI： 10.1016/j.phymed.2019.152902 　

ISSN： 0944-7113

eISSN： 1618-095X
Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol. International-journal Peer-reviewed

Takumi Kokumai, Junya Ito, Eri Kobayashi, Naoki Shimizu, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

Nutrients　11　(5)　2019/05/25

DOI： 10.3390/nu11051174 　

eISSN： 2072-6643
Evaluation of lipid oxidation mechanisms in beverages and cosmetics via analysis of lipid hydroperoxide isomers. International-journal Peer-reviewed

Junya Ito, Marina Komuro, Isabella Supardi Parida, Naoki Shimizu, Shunji Kato, Yasuhiro Meguro, Yusuke Ogura, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　9　(1)　7387-7387　2019/05/14

DOI： 10.1038/s41598-019-43645-1 　

eISSN： 2045-2322
Decrease in Intramuscular Levels of Phosphatidylethanolamine Bearing Arachidonic Acid During Postmortem Aging Depends on Meat Cuts and Breed Peer-reviewed

Shinji Yamashita, Kenichiro Shimada, Riho Sakurai, Nohara Yasuda, Nayoko Oikawa, Reina Kamiyoshihara, Yurika Otoki, Kiyotaka Nakagawa, Teruo Miyazawa, Mikio Kinoshita

European Journal of Lipid Science and Technology　121　(5)　2019/05

DOI： 10.1002/ejlt.201800370 　

ISSN： 1438-7697

eISSN： 1438-9312
Vitamin E: Regulatory Redox Interactions. International-journal Peer-reviewed

Taiki Miyazawa, Gregor C Burdeos, Mayuko Itaya, Kiyotaka Nakagawa, Teruo Miyazawa

IUBMB life　71　(4)　430-441　2019/04

DOI： 10.1002/iub.2008 　

ISSN： 1521-6543

eISSN： 1521-6551
Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol. International-journal Peer-reviewed

Eri Kobayashi, Junya Ito, Naoki Shimizu, Takumi Kokumai, Shunji Kato, Kazue Sawada, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

Nutrients　11　(1)　104　2019/01/06

DOI： 10.3390/nu11010104 　

eISSN： 2072-6643
Physiological Effects and Organ Distribution of Bacillus amyloliquefaciens AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice. Peer-reviewed

Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Teruo Miyazawa, Takahiro Eitsuka, Kiyotaka Nakagawa

Journal of nutritional science and vitaminology　65　(2)　157-163　2019

DOI： 10.3177/jnsv.65.157 　

ISSN： 0301-4800

eISSN： 1881-7742
Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. International-journal Peer-reviewed

Tomokazu Fukuda, Ryo Gouko, Takahiro Eitsuka, Ryusei Suzuki, Kohei Takahashi, Kiyotaka Nakagawa, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono

Frontiers in genetics　10　(JUN)　587-587　2019

DOI： 10.3389/fgene.2019.00587 　

eISSN： 1664-8021
Establishment of immortalized primary cell from the critically endangered Bonin flying fox (Pteropus pselaphon). International-journal Peer-reviewed

Tetsuya Tani, Takahiro Eitsuka, Masafumi Katayama, Takashi Nagamine, Yumiko Nakaya, Hajime Suzuki, Tohru Kiyono, Kiyotaka Nakagawa, Miho Inoue-Murayama, Manabu Onuma, Tomokazu Fukuda

PloS one　14　(8)　e0221364　2019

DOI： 10.1371/journal.pone.0221364 　

eISSN： 1932-6203
Kinetic Study of the Quenching Reaction of Singlet Oxygen by Eight Vegetable Oils in Solution. Peer-reviewed

Kazuo Mukai, Ayaka Ohara, Junya Ito, Masayuki Hirata, Eri Kobayashi, Kiyotaka Nakagawa, Shin-Ichi Nagaoka

Journal of oleo science　68　(1)　21-31　2019/01/01

DOI： 10.5650/jos.ess18179 　

ISSN： 1345-8957

eISSN： 1347-3352
Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. International-journal Peer-reviewed

Ryo Gouko, Manabu Onuma, Takahiro Eitsuka, Masafumi Katayama, Kouhei Takahashi, Kiyotaka Nakagawa, Miho Inoue-Murayama, Tohru Kiyono, Tomokazu Fukuda

Cytotechnology　70　(6)　1619-1630　2018/12

DOI： 10.1007/s10616-018-0254-0 　

ISSN： 0920-9069

eISSN： 1573-0778
Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. International-journal Peer-reviewed

Natsumi Hayasaka, Naoki Shimizu, Toshikazu Komoda, Satoshi Mohri, Tojiro Tsushida, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of agricultural and food chemistry　66　(43)　11320-11329　2018/10/31

DOI： 10.1021/acs.jafc.8b03273 　

ISSN： 0021-8561

eISSN： 1520-5118
Oxidation of squalene by singlet oxygen and free radicals results in different compositions of squalene monohydroperoxide isomers. International-journal Peer-reviewed

Naoki Shimizu, Junya Ito, Shunji Kato, Yurika Otoki, Masashi Goto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　8　(1)　9116-9116　2018/06/14

DOI： 10.1038/s41598-018-27455-5 　

eISSN： 2045-2322
Development of quantitation method for glycated aminophospholipids at the molecular species level in powdered milk and powdered buttermilk. International-journal Peer-reviewed

Ai Kodate, Yurika Otoki, Naoki Shimizu, Junya Ito, Shunji Kato, Naoki Umetsu, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　8　(1)　8729-8729　2018/06/07

DOI： 10.1038/s41598-018-27010-2 　

eISSN： 2045-2322
Kinetic Study of the Scavenging Reaction of the Aroxyl Radical by Eight Kinds of Vegetable Oils in Solution Peer-reviewed

Kazuo Mukai, Yuki Bandoh, Junya Ito, Eri Kobayashi, Kiyotaka Nakagawa, Shin ichi Nagaoka

JAOCS, Journal of the American Oil Chemists' Society　95　(6)　731-742　2018/06

DOI： 10.1002/aocs.12076 　

ISSN： 0003-021X

eISSN： 1558-9331
Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. International-journal Peer-reviewed

Ayano Imai, Yuriko Oda, Naoki Ito, Shinobu Seki, Kiyotaka Nakagawa, Teruo Miyazawa, Fumitaka Ueda

Nutrients　10　(3)　E281-E281　2018/02/28

DOI： 10.3390/nu10030281 　

eISSN： 2072-6643
Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review. International-journal Peer-reviewed

Takahiro Eitsuka, Kiyotaka Nakagawa, Shunji Kato, Junya Ito, Yurika Otoki, Soo Takasu, Naoki Shimizu, Takumi Takahashi, Teruo Miyazawa

International journal of molecular sciences　19　(2)　478-478　2018/02/06

DOI： 10.3390/ijms19020478 　

ISSN： 1661-6596

eISSN： 1422-0067
Effects of Extraction Methods on Phytochemicals of Rice Bran Oils Produced from Colored Rice. Peer-reviewed

Sukanya Mingyai, Khongsak Srikaeo, Aikkarach Kettawan, Riantong Singanusong, Kiyotaka Nakagawa, Fumiko Kimura, Junya Ito

Journal of oleo science　67　(2)　135-142　2018/02/01

DOI： 10.5650/jos.ess17122 　

ISSN： 1345-8957

eISSN： 1347-3352
Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. International-journal Peer-reviewed

Taiki Miyazawa, Reina Kamiyoshihara, Naoki Shimizu, Takahiro Harigae, Yurika Otoki, Junya Ito, Shunji Kato, Teruo Miyazawa, Kiyotaka Nakagawa

Royal Society open science　5　(2)　171249-171249　2018/02

DOI： 10.1098/rsos.171249 　

eISSN： 2054-5703
HPLC-MS/MS: A potential method to track the in vivo degradation of zein-based biomaterial. International-journal Peer-reviewed

Hua-Jie Wang, Yue Zhang, Shunji Kato, Kiyotaka Nakagawa, Fumiko Kimura, Teruo Miyazawa, Jin-Ye Wang

Journal of biomedical materials research. Part A　106　(2)　606-613　2018/02

DOI： 10.1002/jbm.a.36252 　

ISSN： 1549-3296

eISSN： 1552-4965
Identification of OsGGR2, a second geranylgeranyl reductase involved in α-tocopherol synthesis in rice. International-journal Peer-reviewed

Eiichi Kimura, Takumi Abe, Kazumasa Murata, Toshiyuki Kimura, Yurika Otoki, Taiji Yoshida, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　8　(1)　1870-1870　2018/01/30

DOI： 10.1038/s41598-018-19527-3 　

eISSN： 2045-2322
Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin. International-journal Peer-reviewed

Soo Takasu, Isabella Supardi Parida, Shinji Onose, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Oki Higuchi, Fukuyo Tanaka, Toshiyuki Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

PloS one　13　(6)　e0199057　2018

DOI： 10.1371/journal.pone.0199057 　

eISSN： 1932-6203
Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β. International-journal Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Sharon H Kim, Michael J Thomas, Ligi Paul, Jean-Marc Zingg, Gregory G Dolnikowski, Susan B Roberts, Fumiko Kimura, Teruo Miyazawa, Angelo Azzi, Mohsen Meydani

Nutrition & metabolism　15　(1)　12-12　2018

DOI： 10.1186/s12986-018-0250-6 　

eISSN： 1743-7075
Determination of triacylglycerol oxidation mechanisms in canola oil using liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

Shunji Kato, Naoki Shimizu, Yasuhiko Hanzawa, Yurika Otoki, Junya Ito, Fumiko Kimura, Susumu Takekoshi, Masayoshi Sakaino, Takashi Sano, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

NPJ science of food　2　(1)　1-1　2018

DOI： 10.1038/s41538-017-0009-x 　

eISSN： 2396-8370
Determination of pyrroloquinoline quinone by enzymatic and LC-MS/MS methods to clarify its levels in foods. International-journal Peer-reviewed

Chikara Kato, Emiko Kawai, Naoki Shimizu, Tsuyoshi Mikekado, Fumiko Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

PloS one　13　(12)　e0209700　2018

DOI： 10.1371/journal.pone.0209700 　

eISSN： 1932-6203
Analysis of Lutein in Mugwort (Artemisia princeps Pamp.) Paste and Evaluation of Manufacturing Processes. Peer-reviewed

Marina Komuro, Naoki Shimizu, Ryo Onuma, Yurika Otoki, Junya Ito, Shunji Kato, Ohki Higuchi, Keiichi Sudo, Seiichiro Suzuki, Teruo Miyazawa, Takahiro Eitsuka, Kiyotaka Nakagawa

Journal of oleo science　66　(11)　1257-1262　2017/11/01

DOI： 10.5650/jos.ess17117 　

ISSN： 1345-8957

eISSN： 1347-3352
High purity tocotrienols attenuate atherosclerotic lesion formation in apoE-KO mice. International-journal Peer-reviewed

Akira Shibata, Teiko Kobayashi, Akira Asai, Takahiro Eitsuka, Shinichi Oikawa, Teruo Miyazawa, Kiyotaka Nakagawa

The Journal of nutritional biochemistry　48　44-50　2017/10

DOI： 10.1016/j.jnutbio.2017.06.009 　

ISSN： 0955-2863

eISSN： 1873-4847
A novel chiral stationary phase LC-MS/MS method to evaluate oxidation mechanisms of edible oils. International-journal Peer-reviewed

Junya Ito, Naoki Shimizu, Eri Kobayashi, Yasuhiko Hanzawa, Yurika Otoki, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

Scientific reports　7　(1)　10026-10026　2017/08/30

DOI： 10.1038/s41598-017-10536-2 　

eISSN： 2045-2322
Oral Administration of Ethanolamine Glycerophospholipid Containing a High Level of Plasmalogen Improves Memory Impairment in Amyloid β-Infused Rats. International-journal Peer-reviewed

Shinji Yamashita, Michio Hashimoto, Abdul Md Haque, Kiyotaka Nakagawa, Mikio Kinoshita, Osamu Shido, Teruo Miyazawa

Lipids　52　(7)　575-585　2017/07

DOI： 10.1007/s11745-017-4260-3 　

ISSN： 0024-4201

eISSN： 1558-9307
Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. Peer-reviewed

Shuang E, Kazushi Yamamoto, Yu Sakamoto, Yui Mizowaki, Yui Iwagaki, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa, Tsuyoshi Tsuduki

Journal of clinical biochemistry and nutrition　61　(1)　47-52　2017/07

DOI： 10.3164/jcbn.16-94 　

ISSN： 0912-0009
Oral administration of ethanolamine glycerophospholipid from ascidian viscera improves memory impairment in amyloid β-infused rats Peer-reviewed

Yamashita, S, Hashimoto, M, Haque, Md.A, Nakagawa, K, Kinoshita, M, Shido, O, Miyazawa, T

Lipids　52　575-585　2017/07

DOI： 10.1007/s11745-017-4260-3 　

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High-fat Diet Increases Phospholipid Peroxidation in the Liver of Mature Fischer 344 Rats. Peer-reviewed

Saki Hayasaka, Fumiko Kimura, Shunji Kato, Naoki Shimizu, Junya Ito, Oki Higuchi, Katsuhiro Izumisawa, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of oleo science　66　(6)　607-614　2017/06/01

DOI： 10.5650/jos.ess16225 　

ISSN： 1345-8957

eISSN： 1347-3352
Plasma Phosphatidylethanolamine and Triacylglycerol Fatty Acid Concentrations are Altered in Major Depressive Disorder Patients with Seasonal Pattern. International-journal Peer-reviewed

Yurika Otoki, Marie Hennebelle, Anthony J Levitt, Kiyotaka Nakagawa, Walter Swardfager, Ameer Y Taha

Lipids　52　(6)　559-571　2017/06

DOI： 10.1007/s11745-017-4254-1 　

ISSN： 0024-4201

eISSN： 1558-9307
Evaluation of the Mechanisms of Mayonnaise Phospholipid Oxidation. Peer-reviewed

Shunji Kato, Tatsuya Iseki, Yasuhiko Hanzawa, Yurika Otoki, Junya Ito, Fumiko Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of oleo science　66　(4)　369-374　2017/04/03

DOI： 10.5650/jos.ess16187 　

ISSN： 1345-8957

eISSN： 1347-3352
Mass Spectrometric Discrimination of Squalene Monohydroperoxide Isomers. Peer-reviewed

Naoki Shimizu, Hannah Bersabe, Junya Ito, Shunji Kato, Ryo Towada, Takahiro Eitsuka, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of oleo science　66　(3)　227-234　2017/03/01

DOI： 10.5650/jos.ess16159 　

ISSN： 1345-8957

eISSN： 1347-3352
Lactose Increases the Production of 1-deoxynojirimycin in Bacillus amyloliquefaciens Peer-reviewed

Kenji Yamagishi, Shinji Onose, So Takasu, Junya Ito, Ryoichi Ikeda, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa

FOOD SCIENCE AND TECHNOLOGY RESEARCH　23　(2)　349-353　2017/03

DOI： 10.3136/fstr.23.349 　

ISSN： 1344-6606
Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography-tandem mass spectrometry. International-journal Peer-reviewed

Yurika Otoki, Shunji Kato, Fumiko Kimura, Katsutoshi Furukawa, Shinji Yamashita, Hiroyuki Arai, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of pharmaceutical and biomedical analysis　134　77-85　2017/02/05

DOI： 10.1016/j.jpba.2016.11.019 　

ISSN： 0731-7085

eISSN： 1873-264X
Modulation of cAMP levels by high-fat diet and curcumin and regulatory effects on CD36/FAT scavenger receptor/fatty acids transporter gene expression. International-journal Peer-reviewed

Jean-Marc Zingg, Syeda T Hasan, Kiyotaka Nakagawa, Elisa Canepa, Roberta Ricciarelli, Luis Villacorta, Angelo Azzi, Mohsen Meydani

BioFactors (Oxford, England)　43　(1)　42-53　2017/01/02

DOI： 10.1002/biof.1307 　

ISSN： 0951-6433

eISSN： 1872-8081
Identification of a Genetic Factor Required for High γ-Isoform Concentration in Rice Vitamin E. International-journal Peer-reviewed

Daisuke Sekine, Kazumasa Murata, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of agricultural and food chemistry　64　(49)　9368-9373　2016/12/14

DOI： 10.1021/acs.jafc.6b04801 　

ISSN： 0021-8561

eISSN： 1520-5118
Presence of orally administered rice bran oil γ-oryzanol in its intact form in mouse plasma. International-journal Peer-reviewed

Eri Kobayashi, Junya Ito, Shunji Kato, Kazue Sawada, Midori Matsuki, Hiroyuki Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa

Food & function　7　(12)　4816-4822　2016/12/07

DOI： 10.1039/c6fo01552b 　

ISSN： 2042-6496

eISSN： 2042-650X
A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. International-journal Peer-reviewed

Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Toshiharu Nagai, Teruo Miyazawa

Analytical and bioanalytical chemistry　408　(27)　7785-7793　2016/11

DOI： 10.1007/s00216-016-9882-4 　

ISSN： 1618-2642

eISSN： 1618-2650
δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling. International-journal Peer-reviewed

Gregor Carpentero Burdeos, Junya Ito, Takahiro Eitsuka, Kiyotaka Nakagawa, Fumiko Kimura, Teruo Miyazawa

Food & function　7　(10)　4170-4174　2016/10/12

DOI： 10.1039/c6fo00826g 　

ISSN： 2042-6496

eISSN： 2042-650X
Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review. International-journal Peer-reviewed

Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Kiyotaka Nakagawa, Teruo Miyazawa

International journal of molecular sciences　17　(10)　1605　2016/09/22

DOI： 10.3390/ijms17101605 　

ISSN： 1661-6596

eISSN： 1422-0067
α-Tocopherol Attenuates the Triglyceride- and Cholesterol-Lowering Effects of Rice Bran Tocotrienol in Rats Fed a Western Diet. International-journal Peer-reviewed

Akira Shibata, Yuki Kawakami, Toshiyuki Kimura, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of agricultural and food chemistry　64　(26)　5361-6　2016/07/06

DOI： 10.1021/acs.jafc.6b02228 　

ISSN： 0021-8561

eISSN： 1520-5118
Metabolic Fate of Luteolin in Rats: Its Relationship to Anti-inflammatory Effect. International-journal Peer-reviewed

Ayako Kure, Kiyotaka Nakagawa, Momoko Kondo, Shunji Kato, Fumiko Kimura, Akio Watanabe, Naoki Shoji, Sakiko Hatanaka, Tojiro Tsushida, Teruo Miyazawa

Journal of agricultural and food chemistry　64　(21)　4246-54　2016/06/01

DOI： 10.1021/acs.jafc.6b00964 　

ISSN： 0021-8561

eISSN： 1520-5118
The combination of maternal and offspring high-fat diets causes marked oxidative stress and development of metabolic syndrome in mouse offspring. International-journal Peer-reviewed

Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

Life sciences　151　70-75　2016/04/15

DOI： 10.1016/j.lfs.2016.02.089 　

ISSN： 0024-3205

eISSN： 1879-0631
Analysis of Plasmalogen Species in Foodstuffs. International-journal Peer-reviewed

Shinji Yamashita, Susumu Kanno, Ayako Honjo, Yurika Otoki, Kiyotaka Nakagawa, Mikio Kinoshita, Teruo Miyazawa

Lipids　51　(2)　199-210　2016/02

DOI： 10.1007/s11745-015-4112-y 　

ISSN： 0024-4201

eISSN： 1558-9307
Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids. International-journal Peer-reviewed

Shinji Yamashita, Takehiro Kiko, Hironori Fujiwara, Michio Hashimoto, Kiyotaka Nakagawa, Mikio Kinoshita, Katsutoshi Furukawa, Hiroyuki Arai, Teruo Miyazawa

Journal of Alzheimer's disease : JAD　50　(2)　527-37　2016

DOI： 10.3233/JAD-150640 　

ISSN： 1387-2877

eISSN： 1875-8908
Effect of Gelatin Cross-linking on the Characteristics of Fish Oil Powder Peer-reviewed

Yasuhiko Hanzawa, Kiyotaka Nakagawa, Shigeta Aoki, Junya Ito, Shunsuke Matsumoto, Mitsuaki Akutsu, Makoto Kanauchi, Teruo Miyazawa

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI　63　(5)　209-216　2016

DOI： 10.3136/nskkk.63.209 　

ISSN： 1341-027X
A Combination of δ-Tocotrienol and Ferulic Acid Synergistically Inhibits Telomerase Activity in DLD-1 Human Colorectal Adenocarcinoma Cells. Peer-reviewed

Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of nutritional science and vitaminology　62　(5)　281-287　2016

DOI： 10.3177/jnsv.62.281 　

ISSN： 0301-4800

eISSN： 1881-7742
Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration. International-journal Peer-reviewed

Takahiro Harigae, Kiyotaka Nakagawa, Taiki Miyazawa, Nao Inoue, Fumiko Kimura, Ikuo Ikeda, Teruo Miyazawa

International journal of nanomedicine　11　3009-22　2016

DOI： 10.2147/IJN.S107442 　

ISSN： 1176-9114

eISSN： 1178-2013
MS/MS and LC-MS/MS analysis of choline/ethanolamine plasmalogens via promotion of alkali metal adduct formation. International-journal Peer-reviewed

Yurika Otoki, Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences　1004　85-92　2015/11/01

DOI： 10.1016/j.jchromb.2015.09.012 　

ISSN： 1570-0232

eISSN： 1873-376X
δ-Tocotrienol treatment is more effective against hypoxic tumor cells than normoxic cells: potential implications for cancer therapy. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Tsuyoshi Tsuduki, Teruo Miyazawa

The Journal of nutritional biochemistry　26　(8)　832-40　2015/08

DOI： 10.1016/j.jnutbio.2015.02.011 　

ISSN： 0955-2863

eISSN： 1873-4847
α-Tocopherol suppresses antiangiogenic effect of δ-tocotrienol in human umbilical vein endothelial cells. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Tsuyoshi Tsuduki, Teruo Miyazawa

The Journal of nutritional biochemistry　26　(4)　345-50　2015/04

DOI： 10.1016/j.jnutbio.2014.11.010 　

ISSN： 0955-2863

eISSN： 1873-4847
Direct separation of the diastereomers of phosphatidylcholine hydroperoxide bearing 13-hydroperoxy-9Z,11E-octadecadienoic acid using chiral stationary phase high-performance liquid chromatography. International-journal Peer-reviewed

Junya Ito, Kiyotaka Nakagawa, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Toshiharu Nagai, Teruo Miyazawa

Journal of chromatography. A　1386　53-61　2015/03/20

DOI： 10.1016/j.chroma.2015.01.080 　

ISSN： 0021-9673

eISSN： 1873-3778
Metabolism and cytotoxic effects of phosphatidylcholine hydroperoxide in human hepatoma HepG2 cells. International-journal Peer-reviewed

Yuuri Suzuki, Kiyotaka Nakagawa, Shunji Kato, Naoto Tatewaki, Shunsuke Mizuochi, Junya Ito, Takahiro Eitsuka, Hiroshi Nishida, Teruo Miyazawa

Biochemical and biophysical research communications　458　(4)　920-7　2015/03/20

DOI： 10.1016/j.bbrc.2015.02.063 　

ISSN： 0006-291X

eISSN： 1090-2104
Liquid chromatography-tandem mass spectrometry determination of human plasma 1-palmitoyl-2-hydroperoxyoctadecadienoyl-phosphatidylcholine isomers via promotion of sodium adduct formation. International-journal Peer-reviewed

Shunji Kato, Kiyotaka Nakagawa, Yuuri Suzuki, Akira Asai, Mototsugu Nagao, Kazuyuki Nagashima, Shinichi Oikawa, Teruo Miyazawa

Analytical biochemistry　471　51-60　2015/02/15

DOI： 10.1016/j.ab.2014.10.017 　

ISSN： 0003-2697

eISSN： 1096-0309
Effect of a Traditional Japanese Dish Consisting of Boiled Fish Paste on Lipid Metabolism in Rats Peer-reviewed

Yausna Kitano, Yumiko Nakamura, Shuang E. Yu Hatakeyama, Kazushi Yamamoto, Yu Sakamoto, Tsuyoshi Tsuduki, Kiyotaka Nakagawa, Teruo Miyazawa

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI　62　(4)　182-190　2015

DOI： 10.3136/nskkk.62.182 　

ISSN： 1341-027X
Determination of Phosphatidylcholine Hydroperoxide (PCOOH) as a Marker of Membrane Lipid Peroxidation. Peer-reviewed

Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

Journal of nutritional science and vitaminology　61 Suppl　S78-80-S80　2015

DOI： 10.3177/jnsv.61.S78 　

ISSN： 0301-4800

eISSN： 1881-7742
Tandem mass spectrometry analysis of linoleic and arachidonic acid hydroperoxides via promotion of alkali metal adduct formation. International-journal Peer-reviewed

Junya Ito, Shunsuke Mizuochi, Kiyotaka Nakagawa, Shunji Kato, Teruo Miyazawa

Analytical chemistry　87　(9)　4980-7　2015

DOI： 10.1021/acs.analchem.5b00851 　

ISSN： 0003-2700

eISSN： 1520-6882
Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. International-journal Peer-reviewed

Akio Watanabe, Momochika Kumagai, Takashi Mishima, Junya Ito, Yurika Otoki, Teppei Harada, Tsuyoshi Kato, Mikihiko Yoshida, Misora Suzuki, Izumi Yoshida, Kazuhiro Fujita, Masatoshi Watai, Kiyotaka Nakagawa, Teruo Miyazawa

PloS one　10　(5)　e0127158　2015

DOI： 10.1371/journal.pone.0127158 　

eISSN： 1932-6203
Carbon tetrachloride-induced hepatic and renal damages in rat: inhibitory effects of cacao polyphenol. International-journal Peer-reviewed

Koichiro Suzuki, Kiyotaka Nakagawa, Takayuki Yamamoto, Taiki Miyazawa, Fumiko Kimura, Masanori Kamei, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　79　(10)　1669-75　2015

DOI： 10.1080/09168451.2015.1039481 　

ISSN： 0916-8451

eISSN： 1347-6947
Young persimmon ingestion suppresses lipid oxidation in rats. Peer-reviewed

Saki Fushimi, Fumiko Myazawa, Kiyotaka Nakagawa, Gregor Carpentero Burdeos, Teruo Miyazawa

Journal of nutritional science and vitaminology　61　(1)　90-5　2015

DOI： 10.3177/jnsv.61.90 　

ISSN： 0301-4800

eISSN： 1881-7742
Extrinsic plasmalogens suppress neuronal apoptosis in mouse neuroblastoma Neuro-2A cells: importance of plasmalogen molecular species Peer-reviewed

Shinji Yamashita, Susumu Kanno, Kiyotaka Nakagawa, Mikio Kinoshita, Teruo Miyazawa

RSC ADVANCES　5　(75)　61012-61020　2015

DOI： 10.1039/c5ra00632e 　

ISSN： 2046-2069

eISSN： 2046-2069
Kinetic study of the quenching reaction of singlet oxygen by seven rice bran extracts in ethanol solution. Development of a singlet oxygen absorption capacity (SOAC) assay method. International-journal Peer-reviewed

Kazuo Mukai, Eri Ishikawa, Takumi Abe, Aya Ouchi, Shin-Ichi Nagaoka, Kazumasa Murata, Teruo Miyazawa, Kiyotaka Nakagawa

Bioscience, biotechnology, and biochemistry　79　(12)　2063-72　2015

DOI： 10.1080/09168451.2015.1069701 　

ISSN： 0916-8451

eISSN： 1347-6947
Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study. Peer-reviewed

Isao Yamazaki, Fumiko Kimura, Kiyotaka Nakagawa, Kunihiko Nakai, Takahiro Arima, Terue Kawabata, Yasuo Kagawa, Shoji Saitoh, Satoshi Mizuno, Nobuo Yaegashi, Teruo Miyazawa

Journal of oleo science　64　(8)　905-14　2015

DOI： 10.5650/jos.ess15071 　

ISSN： 1345-8957

eISSN： 1347-3352
Distribution of β-carotene-encapsulated polysorbate 80-coated poly(D, L-lactide-co-glycolide) nanoparticles in rodent tissues following intravenous administration. International-journal Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Takahiro Harigae, Ryo Onuma, Fumiko Kimura, Tomoyuki Fujii, Teruo Miyazawa

International journal of nanomedicine　10　7223-30　2015

DOI： 10.2147/IJN.S94336 　

ISSN： 1176-9114

eISSN： 1178-2013
Kinetic study of the scavenging reaction of the aroxyl radical by seven kinds of rice bran extracts in ethanol solution. Development of an aroxyl radical absorption capacity (ARAC) assay method. International-journal Peer-reviewed

Kazuo Mukai, Aya Ouchi, Takumi Abe, Kazumasa Murata, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of agricultural and food chemistry　62　(49)　11901-9　2014/12/10

DOI： 10.1021/jf503996z 　

ISSN： 0021-8561

eISSN： 1520-5118
Separation and detection of plasmalogen in marine invertebrates by high-performance liquid chromatography with evaporative light-scattering detection. International-journal Peer-reviewed

Shinji Yamashita, Akihiro Abe, Kiyotaka Nakagawa, Mikio Kinoshita, Teruo Miyazawa

Lipids　49　(12)　1261-73　2014/12

DOI： 10.1007/s11745-014-3957-9 　

ISSN： 0024-4201

eISSN： 1558-9307
ピロロキノリンキノン（PQQ）のLC-MS/MS分析 Peer-reviewed

安藤篤正, 武田光峰, 加藤俊治, 木村ふみ子, 仲川清隆, 中野昌彦, 宮澤陽夫

ビタミン　88　(12)　601-609　2014/12
Publisher: THE VITAMIN SOCIETY OF JAPAN
DOI： 10.20632/vso.88.12_601 　

ISSN： 0006-386X

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Pyrroloquinoline quinone (PQQ) is a water-soluble, vitamin-like compound discovered in bacteria as the third redox coenzyme. PQQ is reportedly present especially in natto (fermented soybeans) and tea, and the compound has been reported to have physiological activities such as antioxidant effect and nerve protection. However, the distribution and physiological function of PQQ have been still unclear, probably due to limitation of its analytical method. In this study, we tried to develop a LC-MS/MS method of PQQ. By using a reverse-phase column with an ion-pair reagent (dibutylammonium acetate), PQQ standard could be analyzed at the sensitive order of picogram level. Furthermore, since PQQ could easily react with amino acids including Arg, Gln, Gly, His, Lys, and Phe, a LC-MS/MS method for analysis of PQQ-amino acid adducts was also developed. The developed method could be useful for not only investigation of distribution of PQQ and PQQ-amino acid adducts in nature, but also evaluation of their absorption, metabolism and physiological activities in vivo.
Comparisons of accumulation and excretion of iminosugars among mulberry-feeding specialist Bombyx larvae and non-specialist larvae Peer-reviewed

Masatoshi Hori, Shigeto Komatsubara, Kiyotaka Nakagawa, Oki Higuchi, Shinji Onose, Teruo Miyazawa

APPLIED ENTOMOLOGY AND ZOOLOGY　49　(4)　571-578　2014/11

DOI： 10.1007/s13355-014-0288-5 　

ISSN： 0003-6862

eISSN： 1347-605X
Aculeatin, a coumarin derived from Toddalia asiatica (L.) Lam., enhances differentiation and lipolysis of 3T3-L1 adipocytes. International-journal Peer-reviewed

Akio Watanabe, Tsuyoshi Kato, Yusuke Ito, Izumi Yoshida, Teppei Harada, Takashi Mishima, Kazuhiro Fujita, Masatoshi Watai, Kiyotaka Nakagawa, Teruo Miyazawa

Biochemical and biophysical research communications　453　(4)　787-92　2014/10/31

DOI： 10.1016/j.bbrc.2014.10.027 　

ISSN： 0006-291X

eISSN： 1090-2104
Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid. International-journal Peer-reviewed

Takahiro Eitsuka, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Kiyotaka Nakagawa, Teruo Miyazawa

Biochemical and biophysical research communications　453　(3)　606-11　2014/10/24

DOI： 10.1016/j.bbrc.2014.09.126 　

ISSN： 0006-291X

eISSN： 1090-2104
Tocotrienol modulates crucial lipid metabolism-related genes in differentiated 3T3-L1 preadipocytes. International-journal Peer-reviewed

Gregor Carpentero Burdeos, Kiyotaka Nakagawa, Takumi Abe, Fumiko Kimura, Teruo Miyazawa

Food & function　5　(9)　2221-7　2014/09

DOI： 10.1039/c4fo00463a 　

ISSN： 2042-6496

eISSN： 2042-650X
Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation. International-journal Peer-reviewed

Kiyotaka Nakagawa, Jean-Marc Zingg, Sharon H Kim, Michael J Thomas, Gregory G Dolnikowski, Angelo Azzi, Teruo Miyazawa, Mohsen Meydani

The British journal of nutrition　112　(1)　8-14　2014/07/14

DOI： 10.1017/S0007114514000567 　

ISSN： 0007-1145

eISSN： 1475-2662
1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. International-journal Peer-reviewed

Shuang E, Ryo Kijima, Taro Honma, Kazushi Yamamoto, Yu Hatakeyama, Yasuna Kitano, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa, Tsuyoshi Tsuduki

Experimental gerontology　55　63-9　2014/07

DOI： 10.1016/j.exger.2014.03.025 　

ISSN： 0531-5565

eISSN： 1873-6815
トコトリエノールはアレルギー反応による肝臓の脂質代謝異常を改善する Peer-reviewed

木島遼, 都築毅, 清野慧至, 栗山慶子, 仲川清隆, 宮澤陽夫

ビタミン　88　(5)　275-282　2014/07
Publisher: THE VITAMIN SOCIETY OF JAPAN
DOI： 10.20632/vso.88.5-6_275 　

ISSN： 0006-386X

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We recently reported that allergic reaction induced disruption of liver lipid metabolism and that tocotrienol (T3) had a potential to improve allergic reaction. The goal of this study was to examine the influence of T3 administration on liver lipid metabolism in allergia-induced mice. A model of atopic dermatitis was caused in NC/Nga mice treated with picryl chloride to induce allergic reaction. Allergia-induced mice caused lipid accumulation in the liver. On the other hand, T3 administration attenuated the liver lipid accumulation. The expression levels of the genes related to the liver lipid metabolism in the allergic mice was examined using DNA microarray analysis and quantitative RT-PCR. Allergic reaction caused upregulation of Cdkn1a, which is strongly associated with lipid accumulation, and downregulation of Acox1, which is associated with fatty acid β-oxidation, in the liver of allergic mice. In the liver of T3-administered allergic mice, the changes in the expression levels of Cdkn1a and Acox1 were not observed. These results suggest that T3 administration can improve the disturbance of liver lipid metabolism induced by allergic reaction.
Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells. International-journal Peer-reviewed

Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa

Food chemistry　151　126-32　2014/05/15

DOI： 10.1016/j.foodchem.2013.11.021 　

ISSN： 0308-8146

eISSN： 1873-7072
時代とともに変化した日本食がマウスの肥満発症リスクに与える影響 Peer-reviewed

北野泰奈, 本間太郎, 畠山雄有, 治部祐里, 川上祐生, 都築毅, 仲川清隆, 宮澤陽夫

日本栄養・食糧学会誌　67　(2)　73-85　2014/02
Publisher: Japan Society of Nutrition and Food Science
DOI： 10.4327/jsnfs.67.73 　

ISSN： 0287-3516

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Since the Japanese are known for their long life span, it has been theorized that a Japanese-style diet has potential for health promotion. To identify the health effects of components of the Japanese diet that have changed over the last five decades, we conducted a study to examine their influence on obesity in mice. Based on National Nutrition Survey data, one-week menus of Japanese foods representative of those that used to be consumed in 2005, 1990, 1975 and 1960 were prepared, cooked, and powderized. Each of these diets was given to ICR mice for four weeks. It was found that Japanese food representative of 1975 suppressed lipid accumulation in white adipose tissue and expansion of adipocytes. To examine the underlying mechanisms responsible, we conducted DNA microarray analysis of the liver, which is responsible for lipid energy metabolism, and found that Japanese food representative of 1975 promoted the expression of genes related to high-energy expenditure. We then prepared purified diets mimicking Japanese foods from each period based on their energy balance of protein, fat and carbohydrate, and fed them to mice for four weeks. No significant differences in white adipose tissue weight were evident among the four groups. Overall, our findings suggested that Japanese foods typical of the period around 1975 are more effective than modern Japanese foods for preventing obesity, and that this effect is not dependent on energy balance.
Kinetic study of the scavenging reaction of the aroxyl radical by seven kinds of rice bran extracts in ethanol solution. Development of an aroxyl radical absorption capacity (ARAC) assay method. Peer-reviewed

Mukai, K, Ouchi, A, Abe, T, Murata, K, Nakagawa, K, Miyazawa, T

J. Agric. Food Chem.　62　(42)　10054-10062　2014
Publisher: American Chemical Society (ACS)
DOI： 10.1021/jf402811m 　

ISSN： 0021-8561

eISSN： 1520-5118
MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. International-journal Peer-reviewed

Takehiro Kiko, Kiyotaka Nakagawa, Tsuyoshi Tsuduki, Katsutoshi Furukawa, Hiroyuki Arai, Teruo Miyazawa

Journal of Alzheimer's disease : JAD　39　(2)　253-9　2014

DOI： 10.3233/JAD-130932 　

ISSN： 1387-2877

eISSN： 1875-8908
Organ fusion and defective shoot development in oni3 mutants of rice. Peer-reviewed

Takafumi Akiba, Ken-Ichiro Hibara, Fumiko Kimura, Katsutoshi Tsuda, Kiko Shibata, Mayu Ishibashi, Chihiro Moriya, Kiyotaka Nakagawa, Nori Kurata, Jun-Ichi Itoh, Yukihiro Ito

Plant & cell physiology　55　(1)　42-51　2014/01

DOI： 10.1093/pcp/pct154 　

ISSN： 0032-0781

eISSN： 1471-9053
Elevation of HDL-C in Response to Statin Treatment is Involved in the Regression of Carotid Atherosclerosis Peer-reviewed

Yasushi Ishigaki, Suminori Kono, Hideki Katagiri, Yoshitomo Oka, Shinichi Oikawa

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　21　(10)　1055-1065　2014

DOI： 10.5551/jat.22095 　

ISSN： 1340-3478

eISSN： 1880-3873
Augmentation of blood lipid glycation and lipid oxidation in diabetic patients. International-journal Peer-reviewed

Koichiro Suzuki, Kiyotaka Nakagawa, Teruo Miyazawa

Clinical chemistry and laboratory medicine　52　(1)　47-52　2014/01/01

DOI： 10.1515/cclm-2012-0886 　

ISSN： 1434-6621

eISSN： 1437-4331
Preparation of marine plasmalogen and selective identification of molecular species by LC-MS/MS. Peer-reviewed

Shinji Yamashita, Ayako Honjo, Mizue Aruga, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of oleo science　63　(5)　423-30　2014

DOI： 10.5650/jos.ess13188 　

ISSN： 1345-8957

eISSN： 1347-3352
Preparation of 13 or 9-hydroperoxy-9Z,11E (9E,11E) or 10E,12Z (10E,12E)-octadecadienoic phosphatidylcholine hydroperoxide. Peer-reviewed

Shunji Kato, Kiyotaka Nakagawa, Yuuri Suzuki, Koichiro Suzuki, Shunsuke Mizuochi, Teruo Miyazawa

Journal of oleo science　63　(5)　431-7　2014

DOI： 10.5650/jos.ess13225 　

ISSN： 1345-8957

eISSN： 1347-3352
徐放性粉末魚油の調製 Peer-reviewed

青木茂太, 仲川清隆, 半澤康彦, 松本俊介, 阿久津光紹, 君塚道史, 下山田真, 西川正純, 宮澤陽夫

日本食品科学工学会誌　61　(10)　467-474　2014

DOI： 10.3136/nskkk.61.467 　

ISSN： 1341-027X
脂質・糖質代謝系に焦点を当てた年代別日本食の健康有益性の比較 Peer-reviewed

本間太郎, 北野泰奈, 木島遼, 治部祐里, 川上祐生, 都築毅, 仲川清隆, 宮澤陽夫

日本食品科学工学会誌　60　(10)　541-553　2013/10/15
Publisher: Japanese Society for Food Science and Technology
DOI： 10.3136/nskkk.60.541 　

ISSN： 1341-027X

eISSN： 1881-6681
Investigation of tocotrienol biosynthesis in rice (Oryza sativa L.). International-journal Peer-reviewed

Kentaro Matsuzuka, Eiichi Kimura, Kiyotaka Nakagawa, Kazumasa Murata, Toshiyuki Kimura, Teruo Miyazawa

Food chemistry　140　(1-2)　91-8　2013/09/01

DOI： 10.1016/j.foodchem.2013.02.058 　

ISSN： 0308-8146

eISSN： 1873-7072
Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice. International-journal Peer-reviewed

Tsuyoshi Tsuduki, Ikuko Kikuchi, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa

Food chemistry　139　(1-4)　16-23　2013/08/15

DOI： 10.1016/j.foodchem.2013.02.025 　

ISSN： 0308-8146

eISSN： 1873-7072
Aging decreases antioxidant effects and increases lipid peroxidation in the Apolipoprotein E deficient mouse. Peer-reviewed

Taro Honma, Tsuyoshi Tsuduki, Soko Sugawara, Yasuna Kitano, Junya Ito, Ryo Kijima, Mari Tsubata, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of clinical biochemistry and nutrition　52　(3)　234-40　2013/05

DOI： 10.3164/jcbn.12-85 　

ISSN： 0912-0009
Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species. International-journal Peer-reviewed

Shinji Onose, Ryoichi Ikeda, Kiyotaka Nakagawa, Toshiyuki Kimura, Kenji Yamagishi, Ohki Higuchi, Teruo Miyazawa

Food chemistry　138　(1)　516-23　2013/05/01

DOI： 10.1016/j.foodchem.2012.11.012 　

ISSN： 0308-8146

eISSN： 1873-7072
ONION2 fatty acid elongase is required for shoot development in rice. Peer-reviewed

Katsutoshi Tsuda, Takafumi Akiba, Fumiko Kimura, Mayu Ishibashi, Chihiro Moriya, Kiyotaka Nakagawa, Nori Kurata, Yukihiro Ito

Plant & cell physiology　54　(2)　209-17　2013/02

DOI： 10.1093/pcp/pcs169 　

ISSN： 0032-0781

eISSN： 1471-9053
Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice. Peer-reviewed

Tsuyoshi Tsuduki, Keiko Kuriyama, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of oleo science　62　(10)　825-34　2013

DOI： 10.5650/jos.62.825 　

ISSN： 1345-8957

eISSN： 1347-3352
Chlorella is an effective dietary source of lutein for human erythrocytes. Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Fumiko Kimura, Yuya Nakashima, Isao Maruyama, Ohki Higuchi, Teruo Miyazawa

Journal of oleo science　62　(10)　773-9　2013

DOI： 10.5650/jos.62.773 　

ISSN： 1345-8957

eISSN： 1347-3352
Studies targeting α-glucosidase inhibition, antiangiogenic effects, and lipid modification regulation: background, evaluation, and challenges in the development of food ingredients for therapeutic purposes. International-journal Peer-reviewed

Kiyotaka Nakagawa

Bioscience, biotechnology, and biochemistry　77　(5)　900-8　2013

DOI： 10.1271/bbb.120908 　

ISSN： 0916-8451

eISSN： 1347-6947
Ingestion of Chlorella reduced the oxidation of erythrocyte membrane lipids in senior Japanese subjects. Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Hideo Takekoshi, Ohki Higuchi, Shunji Kato, Momoko Kondo, Fumiko Kimura, Teruo Miyazawa

Journal of oleo science　62　(11)　873-81　2013

DOI： 10.5650/jos.62.873 　

ISSN： 1345-8957

eISSN： 1347-3352
γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. Peer-reviewed

Gregor Carpentero Burdeos, Kiyotaka Nakagawa, Akio Watanabe, Fumiko Kimura, Teruo Miyazawa

Journal of nutritional science and vitaminology　59　(2)　148-51　2013

DOI： 10.3177/jnsv.59.148 　

ISSN： 0301-4800

eISSN： 1881-7742
Oxidative stress during development of alcoholic fatty liver: therapeutic potential of cacao polyphenol. International-journal Peer-reviewed

Koichiro Suzuki, Kiyotaka Nakagawa, Taiki Miyazawa, Shunji Kato, Fumiko Kimura, Masanori Kamei, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　77　(8)　1792-4　2013

DOI： 10.1271/bbb.130380 　

ISSN： 0916-8451

eISSN： 1347-6947
A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect. International-journal Peer-reviewed

Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Ohki Higuchi, Fumiko Kimura, Teruo Miyazawa

Food chemistry　134　(4)　1823-30　2012/10/15

DOI： 10.1016/j.foodchem.2012.03.086 　

ISSN： 0308-8146

eISSN： 1873-7072
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells. International-journal Peer-reviewed

Takahiro Eitsuka, Kiyotaka Nakagawa, Yuichi Ono, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Naoki Shoji, Teruo Miyazawa

FEBS letters　586　(16)　2542-7　2012/07/30

DOI： 10.1016/j.febslet.2012.06.027 　

ISSN： 0014-5793

eISSN： 1873-3468
Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. International-journal Peer-reviewed

Nahoko Shinohara, Tsuyoshi Tsuduki, Junya Ito, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Ikeda

Biochimica et biophysica acta　1821　(7)　980-8　2012/07

DOI： 10.1016/j.bbalip.2012.04.001 　

ISSN： 1388-1981

eISSN： 1879-2618
Tocotrienol attenuates triglyceride accumulation in HepG2 cells and F344 rats. International-journal Peer-reviewed

Gregor Carpentero Burdeos, Kiyotaka Nakagawa, Fumiko Kimura, Teruo Miyazawa

Lipids　47　(5)　471-81　2012/05

DOI： 10.1007/s11745-012-3659-0 　

ISSN： 0024-4201

eISSN： 1558-9307
Lipid glycation and protein glycation in diabetes and atherosclerosis. International-journal Peer-reviewed

Teruo Miyazawa, Kiyotaka Nakagawa, Satoko Shimasaki, Ryoji Nagai

Amino acids　42　(4)　1163-70　2012/04

DOI： 10.1007/s00726-010-0772-3 　

ISSN： 0939-4451

eISSN： 1438-2199
Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse. Peer-reviewed

Satoshi Seino, Yurie Tanaka, Taro Honma, Miyuki Yanaka, Kenta Sato, Nahoko Shinohara, Junya Ito, Tsuyoshi Tsuduki, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Ikeda

Journal of clinical biochemistry and nutrition　50　(2)　152-7　2012/03

DOI： 10.3164/jcbn.11-29 　

ISSN： 0912-0009
Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction Peer-reviewed

Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Ohki Higuchi, Somchai Luemunkong, Teruo Miyazawa

LWT-FOOD SCIENCE AND TECHNOLOGY　45　(2)　226-232　2012/03

DOI： 10.1016/j.lwt.2011.09.008 　

ISSN： 0023-6438
Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment. International-journal Peer-reviewed

Tomokazu Fukuda, Masafumi Katayama, Takayuki Yoshizawa, Takahiro Eitsuka, Hiroaki Mizukami, Kiyotaka Nakagawa, Hisao Ito, Homika Komagata, Sanghoun Song, Sanggun Roh, Yumi Hoshino, Eimei Sato, Hirofumi Hanada, Katsuhiko Nishimori, Teruo Miyazawa, Takafumi Uchida

Bioscience, biotechnology, and biochemistry　76　(7)　1372-7　2012

DOI： 10.1271/bbb.120155 　

ISSN： 0916-8451

eISSN： 1347-6947
Significance of lutein in red blood cells of Alzheimer's disease patients. International-journal Peer-reviewed

Takehiro Kiko, Kiyotaka Nakagawa, Tsuyoshi Tsuduki, Toshihide Suzuki, Hiroyuki Arai, Teruo Miyazawa

Journal of Alzheimer's disease : JAD　28　(3)　593-600　2012

DOI： 10.3233/JAD-2011-111493 　

ISSN： 1387-2877

eISSN： 1875-8908
jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. Peer-reviewed

Nahoko Shinohara, Junya Ito, Tsuyoshi Tsuduki, Taro Honma, Ryo Kijima, Soko Sugawara, Tatsuya Arai, Masao Yamasaki, Aya Ikezaki, Marino Yokoyama, Kazuo Nishiyama, Kiyotaka Nakagawa, Teruo Miyazawa, Ikuo Ikeda

Journal of oleo science　61　(8)　433-41　2012

DOI： 10.5650/jos.61.433 　

ISSN： 1345-8957

eISSN： 1347-3352
Physiological effects and tissue distribution from large doses of tocotrienol in rats. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Hitoshi Shirakawa, Teiko Kobayashi, Yuki Kawakami, Rie Takashima, Ai Ohashi, Shoko Sato, Yusuke Ohsaki, Fumiko Kimura, Toshiyuki Kimura, Tsuyoshi Tsuduki, Michio Komai, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　76　(9)　1805-8　2012

DOI： 10.1271/bbb.120387 　

ISSN： 0916-8451

eISSN： 1347-6947
Amyloid β levels in human red blood cells. International-journal Peer-reviewed

Takehiro Kiko, Kiyotaka Nakagawa, Akira Satoh, Tsuyoshi Tsuduki, Katsutoshi Furukawa, Hiroyuki Arai, Teruo Miyazawa

PloS one　7　(11)　e49620　2012

DOI： 10.1371/journal.pone.0049620 　

eISSN： 1932-6203
Health benefits of vitamin E in grains, cereals and green vegetables Invited Peer-reviewed

Teruo Miyazawa, Kiyotaka Nakagawa, Phumon Sookwong

TRENDS IN FOOD SCIENCE & TECHNOLOGY　22　(12)　651-654　2011/12

DOI： 10.1016/j.tifs.2011.07.004 　

ISSN： 0924-2244
Phosphatidylcholine hydroperoxide promotes VEGF-induced angiogenesis in endothelial cells and rat aorta ring cultures. International-journal Peer-reviewed

Kiyotaka Nakagawa, Akira Shibata, Tatsuya Saito, Phumon Sookwong, Shunji Kato, Tsuyoshi Tsuduki, Kiminori Matsubara, Teruo Miyazawa

Biochimica et biophysica acta　1810　(12)　1205-11　2011/12

DOI： 10.1016/j.bbagen.2011.08.018 　

ISSN： 0304-4165

eISSN： 1872-8006
Amadori-glycated phosphatidylethanolamine, a potential marker for hyperglycemia, in streptozotocin-induced diabetic rats. International-journal Peer-reviewed

Phumon Sookwong, Kiyotaka Nakagawa, Ikuko Fujita, Naoki Shoji, Teruo Miyazawa

Lipids　46　(10)　943-52　2011/10

DOI： 10.1007/s11745-011-3588-3 　

ISSN： 0024-4201

eISSN： 1558-9307
Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. Peer-reviewed

Akira Asai, Kiyotaka Nakagawa, Ohki Higuchi, Toshiyuki Kimura, Yoshihiro Kojima, Jun Kariya, Teruo Miyazawa, Shinichi Oikawa

Journal of diabetes investigation　2　(4)　318-23　2011/08/02

DOI： 10.1111/j.2040-1124.2011.00101.x 　

ISSN： 2040-1116

eISSN： 2040-1124
Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. International-journal Peer-reviewed

Kiyotaka Nakagawa, Takehiro Kiko, Taiki Miyazawa, Gregor Carpentero Burdeos, Fumiko Kimura, Akira Satoh, Teruo Miyazawa

The British journal of nutrition　105　(11)　1563-71　2011/06

DOI： 10.1017/S0007114510005398 　

ISSN： 0007-1145

eISSN： 1475-2662
Fatty acid elongase is required for shoot development in rice. International-journal Peer-reviewed

Yukihiro Ito, Fumiko Kimura, Kazuma Hirakata, Katsutoshi Tsuda, Tomoaki Takasugi, Mitsugu Eiguchi, Kiyotaka Nakagawa, Nori Kurata

The Plant journal : for cell and molecular biology　66　(4)　680-8　2011/05

DOI： 10.1111/j.1365-313X.2011.04530.x 　

ISSN： 0960-7412

eISSN： 1365-313X
Amyloid β-induced erythrocytic damage and its attenuation by carotenoids. International-journal Peer-reviewed

Kiyotaka Nakagawa, Takehiro Kiko, Taiki Miyazawa, Phumon Sookwong, Tsuyoshi Tsuduki, Akira Satoh, Teruo Miyazawa

FEBS letters　585　(8)　1249-54　2011/04/20

DOI： 10.1016/j.febslet.2011.03.060 　

ISSN： 0014-5793
Involvement of Rac GTPase activation in phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to ICAM-1. International-journal Peer-reviewed

Akira Asai, Fumitaka Okajima, Yasushi Nakajima, Mototsugu Nagao, Kiyotaka Nakagawa, Teruo Miyazawa, Shinichi Oikawa

Biochemical and biophysical research communications　406　(2)　273-7　2011/03/11

DOI： 10.1016/j.bbrc.2011.02.032 　

ISSN： 0006-291X

eISSN： 1090-2104
Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice. International-journal Peer-reviewed

Tsuyoshi Tsuduki, Taro Honma, Kiyotaka Nakagawa, Ikuo Ikeda, Teruo Miyazawa

Nutrition (Burbank, Los Angeles County, Calif.)　27　(3)　334-7　2011/03

DOI： 10.1016/j.nut.2010.05.017 　

ISSN： 0899-9007
Plasma carotenoid concentrations before and after supplementation with astaxanthin in middle-aged and senior subjects. International-journal Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Fumiko Kimura, Akira Satoh, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　75　(9)　1856-8　2011

DOI： 10.1271/bbb.110368 　

ISSN： 0916-8451

eISSN： 1347-6947
Erythrocytes carotenoids after astaxanthin supplementation in middle-aged and senior Japanese subjects. Peer-reviewed

Taiki Miyazawa, Kiyotaka Nakagawa, Fumiko Kimura, Akira Satoh, Teruo Miyazawa

Journal of oleo science　60　(10)　495-9　2011

DOI： 10.5650/jos.60.495 　

ISSN： 1345-8957

eISSN： 1347-3352
Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality. International-journal Peer-reviewed

Kiyotaka Nakagawa, Takehiro Kiko, Satoko Kuriwada, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　75　(10)　2030-3　2011

DOI： 10.1271/bbb.110318 　

ISSN： 0916-8451

eISSN： 1347-6947
Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry. International-journal Peer-reviewed

Kiyotaka Nakagawa, Kenta Ogawa, Ohki Higuchi, Toshiyuki Kimura, Teruo Miyazawa, Masatoshi Hori

Analytical biochemistry　404　(2)　217-22　2010/09/15

DOI： 10.1016/j.ab.2010.05.007 　

ISSN： 0003-2697

eISSN： 1096-0309
Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans. Peer-reviewed

Yoshihiro Kojima, Toshiyuki Kimura, Kiyotaka Nakagawa, Akira Asai, Keiji Hasumi, Shinichi Oikawa, Teruo Miyazawa

Journal of clinical biochemistry and nutrition　47　(2)　155-61　2010/09

DOI： 10.3164/jcbn.10-53 　

ISSN： 0912-0009
gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. International-journal Peer-reviewed

Kiyotaka Nakagawa, Akira Shibata, Toru Maruko, Phumon Sookwong, Tsuyoshi Tsuduki, Kayoko Kawakami, Hiroshi Nishida, Teruo Miyazawa

Lipids　45　(9)　833-41　2010/09

DOI： 10.1007/s11745-010-3458-4 　

ISSN： 0024-4201

eISSN： 1558-9307
Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Hiroko Yamanoi, Tsuyoshi Tsuduki, Phumon Sookwong, Ohki Higuchi, Fumiko Kimura, Teruo Miyazawa

The Journal of nutritional biochemistry　21　(8)　702-9　2010/08

DOI： 10.1016/j.jnutbio.2009.04.007 　

ISSN： 0955-2863
LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma. International-journal Peer-reviewed

Naoki Shoji, Kiyotaka Nakagawa, Akira Asai, Ikuko Fujita, Aya Hashiura, Yasushi Nakajima, Shinichi Oikawa, Teruo Miyazawa

Journal of lipid research　51　(8)　2445-53　2010/08

DOI： 10.1194/jlr.D004564 　

ISSN： 0022-2275

eISSN： 1539-7262
alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Phumon Sookwong, Tsuyoshi Tsuduki, Akira Asai, Teruo Miyazawa

Biochemical and biophysical research communications　397　(2)　214-9　2010/06/25

DOI： 10.1016/j.bbrc.2010.05.087 　

ISSN： 0006-291X

eISSN： 1090-2104
Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Yuki Kawakami, Tsuyoshi Tsuzuki, Teruo Miyazawa

Journal of agricultural and food chemistry　58　(11)　7013-20　2010/06/09

DOI： 10.1021/jf100691g 　

ISSN： 0021-8561

eISSN： 1520-5118
Tocotrienol distribution in foods: estimation of daily tocotrienol intake of Japanese population. International-journal Peer-reviewed

Phumon Sookwong, Kiyotaka Nakagawa, Yasuhiro Yamaguchi, Taiki Miyazawa, Shunji Kato, Fumiko Kimura, Teruo Miyazawa

Journal of agricultural and food chemistry　58　(6)　3350-5　2010/03/24

DOI： 10.1021/jf903663k 　

ISSN： 0021-8561

eISSN： 1520-5118
Effects of a high-protein diet on host resistance to Paracoccidioides brasiliensis in mice. International-journal Peer-reviewed

Motoko Oarada, Miki Igarashi, Tsuyoshi Tsuzuki, Katsuhiko Kamei, Katsuya Hirasaka, Takeshi Nikawa, Teruo Miyazawa, Kiyotaka Nakagawa, Tohru Gonoi

Bioscience, biotechnology, and biochemistry　74　(3)　620-6　2010

DOI： 10.1271/bbb.90829 　

ISSN： 0916-8451

eISSN： 1347-6947
Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology. International-journal Peer-reviewed

Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Yasuyo Suzuki, Fumiko Kimura, Ohki Higuchi, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　73　(12)　2684-9　2009/12

DOI： 10.1271/bbb.90543 　

ISSN： 0916-8451

eISSN： 1347-6947
栽培管理の相違がコシヒカリの米糠ビタミンE含量に及ぼす影響 Peer-reviewed

村田和優, 木村俊之, 仲川清隆, 宮澤陽夫

北陸作物学会報　44　8-10　2009/12
Publisher: Society for Crop Science and Plant Breeding of Hokuriku
DOI： 10.19016/hokurikucs.44.0_8 　

ISSN： 0388-8061
Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver. International-journal Peer-reviewed

Tsuyoshi Tsuduki, Yumiko Nakamura, Taro Honma, Kiyotaka Nakagawa, Toshiyuki Kimura, Ikuo Ikeda, Teruo Miyazawa

Journal of agricultural and food chemistry　57　(22)　11024-9　2009/11/25

DOI： 10.1021/jf903132r 　

ISSN： 0021-8561
Antioxidant effect of lutein towards phospholipid hydroperoxidation in human erythrocytes. International-journal Peer-reviewed

Kiyotaka Nakagawa, Takehiro Kiko, Keijiro Hatade, Phumon Sookwong, Hiroyuki Arai, Teruo Miyazawa

The British journal of nutrition　102　(9)　1280-4　2009/11

DOI： 10.1017/S0007114509990316 　

ISSN： 0007-1145

eISSN： 1475-2662
delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Phumon Sookwong, Tsuyoshi Tsuduki, Shinichi Oikawa, Teruo Miyazawa

Journal of agricultural and food chemistry　57　(18)　8696-704　2009/09/23

DOI： 10.1021/jf9012899 　

ISSN： 0021-8561
Effects of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in humans. International-journal Peer-reviewed

Kiyotaka Nakagawa, Kayoko Nakayama, Miho Nakamura, Phumon Sookwong, Tsuyoshi Tsuduki, Hitoshi Niino, Fumiko Kimura, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　73　(9)　2014-7　2009/09

DOI： 10.1271/bbb.90195 　

ISSN： 0916-8451

eISSN： 1347-6947
Effect of dietary oils on host resistance to fungal infection in psychologically stressed mice. International-journal Peer-reviewed

Motoko Oarada, Miki Igarashi, Tsuyoshi Tsuzuki, Nobuyuki Kurita, Tohru Gonoi, Takeshi Nikawa, Katsuya Hirasaka, Teruo Miyazawa, Kiyotaka Nakagawa, Katsuhiko Kamei

Bioscience, biotechnology, and biochemistry　73　(9)　1994-8　2009/09

DOI： 10.1271/bbb.90184 　

ISSN： 0916-8451

eISSN： 1347-6947
Cross-fertilization for enhancing tocotrienol biosynthesis in rice plants and QTL analysis of their F2 progenies. International-journal Peer-reviewed

Phumon Sookwong, Kazumasa Murata, Kiyotaka Nakagawa, Akira Shibata, Toshiyuki Kimura, Masayuki Yamaguchi, Yoichiro Kojima, Teruo Miyazawa

Journal of agricultural and food chemistry　57　(11)　4620-5　2009/06/10

DOI： 10.1021/jf900394t 　

ISSN： 0021-8561
Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1. International-journal Peer-reviewed

Akira Asai, Fumitaka Okajima, Kiyotaka Nakagawa, Daigo Ibusuki, Kyoko Tanimura, Yasushi Nakajima, Mototsugu Nagao, Mariko Sudo, Taro Harada, Teruo Miyazawa, Shinichi Oikawa

Journal of lipid research　50　(5)　957-65　2009/05

DOI： 10.1194/jlr.M800582-JLR200 　

ISSN： 0022-2275

eISSN： 1539-7262
Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). International-journal Peer-reviewed

Teruo Miyazawa, Akira Shibata, Phumon Sookwong, Yuki Kawakami, Takahiro Eitsuka, Akira Asai, Shinichi Oikawa, Kiyotaka Nakagawa

The Journal of nutritional biochemistry　20　(2)　79-86　2009/02

DOI： 10.1016/j.jnutbio.2008.09.003 　

ISSN： 0955-2863
現代日本食と現代米国食を給与したラットの肝臓における網羅的遺伝子発現解析 Peer-reviewed

都築毅, 武鹿直樹, 中村祐美子, 仲川清隆, 五十嵐美樹, 宮澤陽夫

日本栄養・食糧学会誌　61　(6)　255-264　2008/12/10
Publisher: Japan Society of Nutrition and Food Science
DOI： 10.4327/jsnfs.61.255 　

ISSN： 0287-3516

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Japanese food is of interest worldwide as healthy food. However, comparison of Japanese food with European and American food has not been performed using DNA microarray analysis. In this study, we examined differences in gene expression levels in the liver of rats fed "Japanese food" or "American food" using a DNA microarray. Two meals were cooked based on a menu of Japanese food and American food. The cooked meals were prepared to a freeze-dried powder and given to rats for three weeks as test diets. Total RNA was then extracted from rat liver and used in DNA microarray analysis. The expression levels of stress response genes were lower in rats fed Japanese food compared to those fed American food, and expression of genes of the sugar and lipid metabolism system was higher in rats fed Japanese food. Expression of genes associated with cholesterol catabolism increased markedly in rats fed Japanese food, although the ingested lipid content was low, and cholesterol accumulation in rat liver was prevented. Therefore, the results suggest that Japanese food is healthy and profitable compared with American food due to activation of metabolism and reduction of stress.
Preparation of pure lipid hydroperoxides. International-journal Peer-reviewed

Daigo Ibusuki, Kiyotaka Nakagawa, Akira Asai, Shinichi Oikawa, Yuichi Masuda, Toshihide Suzuki, Teruo Miyazawa

Journal of lipid research　49　(12)　2668-77　2008/12

DOI： 10.1194/jlr.D800034-JLR200 　

ISSN： 0022-2275

eISSN： 1539-7262
Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Phumon Sookwong, Tsuyoshi Tsuduki, Shuhei Tomita, Hitoshi Shirakawa, Michio Komai, Teruo Miyazawa

The Journal of nutrition　138　(11)　2136-42　2008/11

DOI： 10.3945/jn.108.093237 　

ISSN： 0022-3166

eISSN： 1541-6100
Tocotrienol content in hen eggs: its fortification by supplementing the feed with rice bran scum oil. International-journal Peer-reviewed

Phumon Sookwong, Kiyotaka Nakagawa, Shin-Ichi Nakajima, Yoshikazu Amano, Masaaki Toyomizu, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　72　(11)　3044-7　2008/11

DOI： 10.1271/bbb.80432 　

ISSN： 0916-8451

eISSN： 1347-6947
Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: application to clinical studies. International-journal Peer-reviewed

Kiyotaka Nakagawa, Takehiro Kiko, Keijiro Hatade, Akira Asai, Fumiko Kimura, Phumon Sookwong, Tsuyoshi Tsuduki, Hiroyuki Arai, Teruo Miyazawa

Analytical biochemistry　381　(1)　129-34　2008/10/01

DOI： 10.1016/j.ab.2008.06.038 　

ISSN： 0003-2697

eISSN： 1096-0309
Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies. International-journal Peer-reviewed

Kiyotaka Nakagawa, Hiroyuki Kubota, Tsuyoshi Tsuzuki, Jun Kariya, Toshiyuki Kimura, Shinichi Oikawa, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　72　(8)　2210-3　2008/08

DOI： 10.1271/bbb.80200 　

ISSN： 0916-8451

eISSN： 1347-6947
Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol. International-journal Peer-reviewed

Akira Shibata, Kiyotaka Nakagawa, Phumon Sookwong, Tsuyoshi Tsuzuki, Shinichi Oikawa, Teruo Miyazawa

Biochemical pharmacology　76　(3)　330-9　2008/08/01

DOI： 10.1016/j.bcp.2008.05.017 　

ISSN： 0006-2952
Long term effect of DNJ-enriched mulberry leaf product Peer-reviewed

T. Kimura, K. Nakagawa, H. Kubota, Y. Kojima, K. Yamagishi, S. Oikawa, T. Miyazawa

J. Clin. Biochem. Nutr.　1　387-389　2008/06

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IF値 0.824
Elongation of anti-hypertensive effect of tea catechin by co-administration with milk protein in spontaneously hypertensive rats Peer-reviewed

K. Ohinata, Z. Hui, H. Fujita, T. Yamagami, K. Nakagawa, T. Miyazawa, M. Yoshikawa

J. Clin. Biochem. Nutr.　1　481-484　2008/06

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IF値 0.824
Cryptococcus neoformans inhibits nitric oxide synthesis caused by CpG-oligodeoxynucleotide-stimulated macrophages in a fashion independent of capsular polysaccharides International-journal

Gang Xiao, Akiko Miyazato, Ken Inden, Kiwamu Nakamura, Kohei Shiratori, Kiyotaka Nakagawa, Teruo Miyazawa, Kazuo Suzuki, Mitsuo Kaku, Kazuyoshi Kawakami

Microbiology and Immunology　52　(3)　171-179　2008/03

DOI： 10.1111/j.1348-0421.2008.00019.x 　

ISSN： 0385-5600

eISSN： 1348-0421
Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice. International-journal Peer-reviewed

Motoko Oarada, Tsuyoshi Tsuzuki, Tohru Gonoi, Miki Igarashi, Katsuhiko Kamei, Takeshi Nikawa, Katsuya Hirasaka, Takayuki Ogawa, Teruo Miyazawa, Kiyotaka Nakagawa, Nobuyuki Kurita

Nutrition (Burbank, Los Angeles County, Calif.)　24　(1)　67-75　2008/01

DOI： 10.1016/j.nut.2007.10.006 　

ISSN： 0899-9007
Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin. International-journal Peer-reviewed

Kiyotaka Nakagawa, Daigo Ibusuki, Yoshihiro Suzuki, Shinji Yamashita, Ohki Higuchi, Shinichi Oikawa, Teruo Miyazawa

Journal of lipid research　48　(12)　2779-87　2007/12

DOI： 10.1194/jlr.D700016-JLR200 　

ISSN： 0022-2275

eISSN： 1539-7262
Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. International-journal Peer-reviewed

Kiyotaka Nakagawa, Hiroyuki Kubota, Toshiyuki Kimura, Shinji Yamashita, Tsuyoshi Tsuzuki, Shinichi Oikawa, Teruo Miyazawa

Journal of agricultural and food chemistry　55　(22)　8928-33　2007/10/31

DOI： 10.1021/jf071559m 　

ISSN： 0021-8561
In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. International-journal Peer-reviewed

Kiyotaka Nakagawa, Akira Shibata, Shinji Yamashita, Tsuyoshi Tsuzuki, Jun Kariya, Shinichi Oikawa, Teruo Miyazawa

The Journal of nutrition　137　(8)　1938-43　2007/08

DOI： 10.1093/jn/137.8.1938 　

ISSN： 0022-3166

eISSN： 1541-6100
Anti-angiogenic effects of conjugated docosahexaenoic acid in vitro and in vivo Peer-reviewed

Tsuyoshi Tsuzuki, Akira Shibata, Yuki Kawakami, Kiyotaka Nakagaya, Teruo Miyazawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　71　(8)　1902-1910　2007/08

DOI： 10.1271/bbb.70114 　

ISSN： 0916-8451

eISSN： 1347-6947
Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. International-journal Peer-reviewed

Toshiyuki Kimura, Kiyotaka Nakagawa, Hiroyuki Kubota, Yoshihiro Kojima, Yuko Goto, Kenji Yamagishi, Shigeru Oita, Shinichi Oikawa, Teruo Miyazawa

Journal of agricultural and food chemistry　55　(14)　5869-74　2007/07/11

DOI： 10.1021/jf062680g 　

ISSN： 0021-8561
Mechanism of cell cycle arrest and apoptosis induction by conjugated eicosapentaenoic acid, which is a mammalian DNA polymerase and topoisomerase inhibitor. International-journal Peer-reviewed

Yuko Yonezawa, Takahiko Hada, Keisuke Uryu, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Teruo Miyazawa, Hiromi Yoshida, Yoshiyuki Mizushina

International journal of oncology　30　(5)　1197-204　2007/05

DOI： 10.3892/ijo.30.5.1197 　

ISSN： 1019-6439

eISSN： 1791-2423
Conjugated eicosapentaenoic acid inhibits vascular endothelial growth factor-induced angiogenesis by suppressing the migration of human umbilical vein endothelial cells. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Akira Shibata, Yuki Kawakami, Kiyotaka Nakagawa, Teruo Miyazawa

The Journal of nutrition　137　(3)　641-6　2007/03

DOI： 10.1093/jn/137.3.641 　

ISSN： 0022-3166

eISSN： 1541-6100
Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate. International-journal Peer-reviewed

Yuki Kawakami, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　71　(2)　464-71　2007/02

DOI： 10.1271/bbb.60524 　

ISSN： 0916-8451

eISSN： 1347-6947
Quantitation of tocotrienol and tocopherol in various rice brans. International-journal Peer-reviewed

Phumon Sookwong, Kiyotaka Nakagawa, Kazamasa Murata, Yoichiro Kojima, Teruo Miyazawa

Journal of agricultural and food chemistry　55　(2)　461-6　2007/01/24

DOI： 10.1021/jf0621572 　

ISSN： 0021-8561
Mitochondrial oxidative damage in chicken skeletal muscle induced by acute heat stress Peer-reviewed

Ahmad Mujahid, Neil R. Pumford, Walter Bottje, Kiyotaka Nakagawa, Teruo Miyazawa, Yukio Akiba, Masaaki Toyomizu

Journal of Poultry Science　44　(4)　439-445　2007

DOI： 10.2141/jpsa.44.439 　

ISSN： 1346-7395 1349-0486

eISSN： 1349-0486
Conjugated EPA activates mutant p53 via lipid peroxidation and induces p53-dependent apoptosis in DLD-1 colorectal adenocarcinoma human cells. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Tomoko Kambe, Akira Shibata, Yuki Kawakami, Kiyotaka Nakagawa, Teruo Miyazawa

Biochimica et biophysica acta　1771　(1)　20-30　2007/01

DOI： 10.1016/j.bbalip.2006.11.006 　

ISSN： 0006-3002
Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice. International-journal Peer-reviewed

Motoko Oarada, Tohru Gonoi, Tsuyoshi Tsuzuki, Miki Igarashi, Katsuya Hirasaka, Takeshi Nikawa, Yuko Onishi, Takahito Toyotome, Katsuhiko Kamei, Teruo Miyazawa, Kiyotaka Nakagawa, Minoru Kashima, Nobuyuki Kurita

Bioscience, biotechnology, and biochemistry　71　(1)　174-82　2007/01

DOI： 10.1271/bbb.60425 　

ISSN： 0916-8451

eISSN： 1347-6947
Evidence of biomembrane lipid glycation Peer-reviewed

Teruo Miyazawa, Naoki Shoji, Kiyotaka Nakagawa

BUNSEKI KAGAKU　55　(12)　907-917　2006/12

DOI： 10.2116/bunsekikagaku.55.907 　

ISSN： 0525-1931
Effects of green tea (Camellia sinensis) waste silage and polyethylene glycol on ruminal fermentation and blood components in cattle

Takehiro Nishida, B. Eruden, K. Hosoda, H. Matsuyama, K. Nakagawa, T. Miyazawa, S. Shioya

Asian-Australasian Journal of Animal Sciences　19　(12)　1728-1736　2006/12

DOI： 10.5713/ajas.2006.1728 　

ISSN： 1011-2367
Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol. International-journal Peer-reviewed

Takahiro Eitsuka, Kiyotaka Nakagawa, Teruo Miyazawa

Biochemical and biophysical research communications　348　(1)　170-5　2006/09/15

DOI： 10.1016/j.bbrc.2006.07.029 　

ISSN： 0006-291X

eISSN： 1090-2104
Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Yuki Kawakami, Kiyotaka Nakagawa, Teruo Miyazawa

The Journal of nutritional biochemistry　17　(8)　518-24　2006/08

DOI： 10.1016/j.jnutbio.2005.09.006 　

ISSN： 0955-2863
Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Yuki Kawakami, Renpei Abe, Kiyotaka Nakagawa, Kazunori Koba, Jun Imamura, Toshio Iwata, Ikuo Ikeda, Teruo Miyazawa

The Journal of nutrition　136　(8)　2153-9　2006/08

DOI： 10.1093/jn/136.8.2153 　

ISSN： 0022-3166

eISSN： 1541-6100
Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5 '-phosphate as the inhibitor International-journal Peer-reviewed

O Higuchi, K Nakagawa, T Tsuzuki, T Suzuki, S Oikawa, T Miyazawa

JOURNAL OF LIPID RESEARCH　47　(5)　964-974　2006/05

DOI： 10.1194/jlr.M500348-JLR200 　

ISSN： 0022-2275

eISSN： 1539-7262
Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents. International-journal Peer-reviewed

Kiyotaka Nakagawa, Toshiko Umeda, Ohki Higuchi, Tsuyoshi Tsuzuki, Toshihide Suzuki, Teruo Miyazawa

Journal of agricultural and food chemistry　54　(7)　2479-83　2006/04/05

DOI： 10.1021/jf051823g 　

ISSN： 0021-8561
Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis. International-journal Peer-reviewed

Yoshiyuki Mizushina, Kiyotaka Nakagawa, Akira Shibata, Yasutoshi Awata, Isoko Kuriyama, Noriko Shimazaki, Osamu Koiwai, Yukinobu Uchiyama, Kengo Sakaguchi, Teruo Miyazawa, Hiromi Yoshida

Biochemical and biophysical research communications　339　(3)　949-55　2006/01/20

DOI： 10.1016/j.bbrc.2005.11.085 　

ISSN： 0006-291X

eISSN： 1090-2104
親水性相互クロマトグラフィーによる桑葉1-デオキシノジリマイシンの新規分析法の開発と展開 Peer-reviewed

仲川清隆, 木村俊之

ぶんせき　9　437-440　2006
Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. International-journal Peer-reviewed

Kiyotaka Nakagawa, Jeong-Ho Oak, Ohki Higuchi, Tsuyoshi Tsuzuki, Shinichi Oikawa, Haruhisa Otani, Masatoshi Mune, Hua Cai, Teruo Miyazawa

Journal of lipid research　46　(11)　2514-24　2005/11

DOI： 10.1194/jlr.D500025-JLR200 　

ISSN： 0022-2275
Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Yuki Kawakami, Yoshihiro Suzuki, Renpei Abe, Kiyotaka Nakagawa, Teruo Miyazawa

Lipids　40　(11)　1117-23　2005/11

DOI： 10.1007/s11745-005-1475-0 　

ISSN： 0024-4201
Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach. International-journal Peer-reviewed

Takahiro Eitsuka, Kiyotaka Nakagawa, Toshihide Suzuki, Teruo Miyazawa

Biochimica et biophysica acta　1737　(1)　1-10　2005/10/15

DOI： 10.1016/j.bbalip.2005.08.017 　

ISSN： 0006-3002
Fatty acids with conjugated unsaturation: relationship between oxidative stability and physiological activities (a review)

T. Miyazawa, T. Tsuzuki, K. Nakagawa, M. Igarashi

Lipid Technol.　17　221-225　2005/10
Oxidized but not acetylated low-density lipoprotein reduces preproinsulin mRNA expression and secretion of insulin from HIT-T15 cells. International-journal Peer-reviewed

Fumitaka Okajima, Mikiko Kurihara, Chihaya Ono, Yasushi Nakajima, Kyoko Tanimura, Hitoshi Sugihara, Atsushi Tatsuguchi, Kiyotaka Nakagawa, Teruo Miyazawa, Shinichi Oikawa

Biochimica et biophysica acta　1687　(1-3)　173-80　2005/02/21

DOI： 10.1016/j.bbalip.2004.11.018 　

ISSN： 0006-3002
Green tea reverses endothelial dysfunction in healthy smokers Peer-reviewed

N Nagaya, H Yamamoto, M Uematsu, T Itoh, K Nakagawa, T Miyazawa, K Kangawa, K Miyatake

HEART　90　(12)　1485-1486　2004/12

DOI： 10.1136/hrt.2003.026740 　

ISSN： 1355-6037
Alpha-eleostearic acid (9Z11E13E-18:3) is quickly converted to conjugated linoleic acid (9Z11E-18:2) in rats. International-journal Peer-reviewed

Tsuyoshi Tsuzuki, Yoshiko Tokuyama, Miki Igarashi, Kiyotaka Nakagawa, Yusuke Ohsaki, Michio Komai, Teruo Miyazawa

The Journal of nutrition　134　(10)　2634-9　2004/10

DOI： 10.1093/jn/134.10.2634 　

ISSN： 0022-3166
Telomerase inhibition by sulfoquinovosyldiacylglycerol from edible purple laver (Porphyra yezoensis). International-journal Peer-reviewed

Takahiro Eitsuka, Kiyotaka Nakagawa, Miki Igarashi, Teruo Miyazawa

Cancer letters　212　(1)　15-20　2004/08/20

DOI： 10.1016/j.canlet.2004.03.019 　

ISSN： 0304-3835
Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. International-journal Peer-reviewed

Toshiyuki Kimura, Kiyotaka Nakagawa, Yuko Saito, Kenji Yamagishi, Masahiro Suzuki, Kohji Yamaki, Hiroshi Shinmoto, Teruo Miyazawa

Journal of agricultural and food chemistry　52　(6)　1415-8　2004/03/24

DOI： 10.1021/jf0306901 　

ISSN： 0021-8561
Ozonation of cholesterol in the presence of ethanol: identification of a cytotoxic ethoxyhydroperoxide molecule. International-journal Peer-reviewed

Misako Tagiri-Endo, Kiyotaka Nakagawa, Tatsuya Sugawara, Kaori Ono, Teruo Miyazawa

Lipids　39　(3)　259-64　2004/03

DOI： 10.1007/s11745-004-1228-0 　

ISSN： 0024-4201
Amadori-glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells. International-journal Peer-reviewed

Jeong-Ho Oak, Kiyotaka Nakagawa, Shinichi Oikawa, Teruo Miyazawa

FEBS letters　555　(2)　419-23　2003/12/04

DOI： 10.1016/S0014-5793(03)01237-7 　

ISSN： 0014-5793
Anti-angiogenic activity of tocotrienol. International-journal Peer-reviewed

Hitoshi Inokuchi, Hisako Hirokane, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Miki Igarashi, Teruo Miyazawa

Bioscience, biotechnology, and biochemistry　67　(7)　1623-7　2003/07

DOI： 10.1271/bbb.67.1623 　

ISSN： 0916-8451

eISSN： 1347-6947
Anthocyanin administration elevates plasma homocysteine in rats. Peer-reviewed

Kiyotaka Nakagawa, Yumiko Maruyama, Teruo Miyazawa

Journal of nutritional science and vitaminology　48　(6)　530-5　2002/12

DOI： 10.3177/jnsv.48.530 　

ISSN： 0301-4800

eISSN： 1881-7742
Measurement of phosphatidylcholine hydroperoxide in mild ischemia-reperfusion injury in rat intestine. Peer-reviewed

Tsuyoshi Masuko, Yuji Funayama, Hiroo Naito, Kohei Fukushima, Chikashi Shibata, Ken-ichi Takahashi, Hitoshi Ogawa, Tatsuya Ueno, Akihiko Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa, Seiki Matsuno, Iwao Sasaki

The Tohoku journal of experimental medicine　198　(4)　223-32　2002/12

DOI： 10.1620/tjem.198.223 　

ISSN： 0040-8727
The occurrence of a novel hydrophilic hydroperoxide, 3-hydroxy-5-hydroperoxy-2-methyl-5,6-dihydropyran-4-one, as a reactive glycation product in human plasma. International-journal

Sittiwat Lertsiri, Jeong-Ho Oak, Kiyotaka Nakagawa, Teruo Miyazawa

Biochimica et biophysica acta　1573　(1)　48-54　2002/10/10

ISSN： 0006-3002

More details Close

This study describes the occurrence of 3-hydroxy-5-hydroperoxy-2-methyl-5,6-dihydropyran-4-one (HMDP) in plasma obtained from normal subjects and patients with type 2 diabetes. We have shown previously that HMDP is a novel hydrophilic hydroperoxide formed in the in vitro Maillard reaction that could be analyzed using ultrasensitive chemiluminescence detection-high-performance liquid chromatography (CL-HPLC). The HMDP concentration was 273+/-227 nmol/l in normal subjects and 656+/-535 nmol/l in patients with diabetes. The HMDP concentration was proportional to the plasma glucose concentration level (r=0.640; P<0.01) but not with the glycated hemoglobin level. To investigate the in vivo effects of HMDP, a range of concentrations of the compound was incubated for different time periods with human serum albumin and lipoproteins. HMDP was found to induce denaturation of these macromolecules by modifying lysine residues and causing cross-linking and polymerization of proteins. In the presence of metal ions such as iron and copper, HMDP induced peroxidative degradation of lipoprotein lipids as measured by an elevation in thiobarbituric acid reactive substances (TBARS) concentration. These results suggested that HMDP is produced as a consequence of both hyperglycemia and increased oxidative stress, and may have the potential to contribute to the pathogenesis of arterial complications in diabetes mellitus.
Ozonation of PC in ethanol: separation and identification of a novel ethoxyhydroperoxide. International-journal Peer-reviewed

Misako Tagiri-Endo, Kaori Ono, Kiyotaka Nakagawa, Mari Yotsu-Yamashita, Teruo Miyazawa

Lipids　37　(10)　1007-12　2002/10

DOI： 10.1007/s11745-006-0993-0 　

ISSN： 0024-4201
UV analysis of Amadori-glycated phosphatidylethanolamine in foods and biological samples. International-journal Peer-reviewed

Jeong-Ho Oak, Kiyotaka Nakagawa, Teruo Miyazawa

Journal of lipid research　43　(3)　523-9　2002/03

ISSN： 0022-2275
Method for Quantitative Determination of Cerebroside in “Plant Ceramide” Foodstuffs by High Performance Liquid Chromatography with Evaporative Light Scattering Detection Peer-reviewed

Minoru Kashima, Kiyotaka Nakagawa, Tatsuya Sugawara, Teruo Miyazawa, Chiaki Murakami, Rumiko Miyashita, Jisaburo Ono, F. S. Deschamps, P. Chaminade

Journal of Oleo Science　51　(5)　347-354　2002

DOI： 10.5650/jos.51.347 　

ISSN： 1347-3352 1345-8957

eISSN： 1347-3352
Preventive effect of onion extract on the formation and cytotoxicity of glycated Amadori-phosphatidylethanolamine Peer-reviewed

Jeong-Ho Oak, Kiyotaka Nakagawa, Kouhei Miyao, Mitsuo Namiki, Teruo Miyazawa

Nippon Shokuhin Kagaku Kogaku Kaishi　49　(10)　646-651　2002
Publisher: Japanese Society for Food Science and Technology
DOI： 10.3136/nskkk.49.646 　

ISSN： 1341-027X
Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis Peer-reviewed

K Moriya, K Nakagawa, T Santa, Y Shintani, H Fujie, H Miyoshi, T Tsutsumi, T Miyazawa, K Ishibashi, T Horie, K Imai, T Todoroki, S Kimura, K Koike

CANCER RESEARCH　61　(11)　4365-4370　2001/06

ISSN： 0008-5472
Synthetically prepared Amadori-glycated phosphatidylethanolamine call trigger lipid peroxidation via free radical reactions Peer-reviewed

JH Oak, K Nakagawa, T Miyazawa

FEBS LETTERS　481　(1)　26-30　2000/09

DOI： 10.1016/S0014-5793(00)01966-9 　

ISSN： 0014-5793
Effect of green tea extracts and green tea grounds as dietary supplements on cultured Yellowtail and Ayu Peer-reviewed

Michiko Kono, Kiyoshi Furukawa, Yuko M. Sagesaka, Kiyotaka Nakagawa, Kenshiro Fujimoto

Nippon Shokuhin Kagaku Kogaku Kaishi　47　(12)　932-937　2000
Publisher: Japanese Society for Food Science and Technology
DOI： 10.3136/nskkk.47.932 　

ISSN： 1341-027X
Antioxidative effect of concentrated plastids of tomato fruit in rats Peer-reviewed

Akira Asai, Yumi Yamada, Kiyotaka Nakagawa, Norihisa Takada, Teruo Miyazawa

Nippon Shokuhin Kagaku Kogaku Kaishi　47　(9)　716-721　2000
Publisher: Japanese Society for Food Science and Technology
DOI： 10.3136/nskkk.47.716 　

ISSN： 1341-027X
Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice Peer-reviewed

A Asai, K Nakagawa, T Miyazawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　63　(12)　2118-2122　1999/12

DOI： 10.1271/bbb.63.2118 　

ISSN： 0916-8451

eISSN： 1347-6947
Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans Peer-reviewed

K Nakagawa, M Ninomiya, T Okubo, N Aoi, LR Juneja, M Kim, K Yamanaka, T Miyazawa

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY　47　(10)　3967-3973　1999/10

DOI： 10.1021/jf981195l 　

ISSN： 0021-8561
Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans Peer-reviewed

T Miyazawa, K Nakagawa, M Kudo, K Muraishi, K Someya

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY　47　(3)　1083-1091　1999/03

DOI： 10.1021/jf9809582 　

ISSN： 0021-8561
Lipid hydroperoxidation in DMH-induced rat colonic carcinogenesis and inhibition by green tea. Peer-reviewed

H. Matsumoto, T. Yamane, K. Nakagawa, H. Nakatani, Y. Iwata, H. Nishino

J. Jpn. Res. Soc. Gastroenterol. Carcinogenesis　10　133-136　1998/05
Structure-related emission spectrometric analysis of the chemiluminescence of catechins, theaflavins and anthocyanins Peer-reviewed

T Miyazawa, K Nakagawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　62　(4)　829-832　1998/04

DOI： 10.1271/bbb.62.829 　

ISSN： 0916-8451

eISSN： 1347-6947
Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma Peer-reviewed

K Nakagawa, S Okuda, T Miyazawa

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY　61　(12)　1981-1985　1997/12

DOI： 10.1271/bbb.61.1981 　

ISSN： 0916-8451

eISSN： 1347-6947
Absorption and distribution of tea catechin, (-)-epigallocatechin-3-gallate, in the rat Peer-reviewed

K Nakagawa, T Miyazawa

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　43　(6)　679-684　1997/12

DOI： 10.3177/jnsv.43.679 　

ISSN： 0301-4800

eISSN： 1881-7742
Inhibition by beta-carotene and astaxanthin of NADPH-dependent microsomal phospholipid peroxidation Peer-reviewed

K Nakagawa, SD Kang, DK Park, GJ Handelman, T Miyazawa

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY　43　(3)　345-355　1997/06

DOI： 10.3177/jnsv.43.345 　

ISSN： 0301-4800

eISSN： 1881-7742
Chemiluminescence high-performance liquid chromatographic determination of tea catechin, (-)-epigallocatechin 3-gallate, at picomole levels in rat and human plasma Peer-reviewed

K Nakagawa, T Miyazawa

ANALYTICAL BIOCHEMISTRY　248　(1)　41-49　1997/05

DOI： 10.1006/abio.1997.2098 　

ISSN： 0003-2697
Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis Peer-reviewed

H Matsumoto, T Yamane, M Inagake, H Nakatani, Y Iwata, T Takahashi, H Nishimura, H Nishino, K Nakagawa, T Miyazawa

CANCER LETTERS　104　(2)　205-209　1996/07

DOI： 10.1016/0304-3835(96)04248-6 　

ISSN： 0304-3835
beta-Carotene as a high-potency antioxidant to prevent the formation of phospholipid hydroperoxides in red blood cells of mice Peer-reviewed

K Nakagawa, K Fujimoto, T Miyazawa

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM　1299　(1)　110-116　1996/01

DOI： 10.1016/0005-2760(95)00203-0 　

ISSN： 0005-2760

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Emerging Roles of Carboxyl-Terminus Lipid Oxidation Products in Advanced Glycation End Product Formation: Insights from Adductome

Miu Yamamoto, Shunji Kato, Kiyotaka Nakagawa

IMARS Highlights　2025/05
巻頭言：食品成分表の食用油のカロリーへの想いと道のり

オレオサイエンス　25　179-180　2025
γ-オリザノールの分子種についての最新の知見

澤田一恵, 松木翠, 橋本博之, 小林由輝, 伊藤隼哉, 仲川清隆

オレオサイエンス　25　191-197　2025
「酸化」のメカニズムがわかると、世界が変わる!? 食品機能分析で目指す豊かな"未来"

仲川清隆

MICHINOOKメールマガジン東北大学偏愛"研究室訪問第5回"　2024
ビタミンEの生理作用解明に向けたタンパク質との結合に関する研究動向

中冨毅, 堀越洋輔, 松浦達也, 仲川清隆

ビタミン　98　2024
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加藤主税, 加藤俊治, 三毛門毅, 仲川清隆

Vitamins　98　353-357　2024
年会に参加して：Session 2 Science on lipids, fats, and oils, nutrition, health function and foods

青柳寛司, 楠本惟吹, 仲川清隆

オレオサイエンス　12　35　2024
オーツ麦に特徴的なジガラクトシルジアシルグリセロール-モノエストリドによる抗炎症作用

伊藤隼哉, 山田皓輝, 石原克之, 仲川清隆

日本栄養・食糧学会誌　77　97-102　2024
酸化脂質の吸収・代謝を紐解く

高橋巧, 仲川清隆

化学と生物　62　2024
ビタミンE類の細胞への取り込み量は大きく異なり、その機構を紐解く

中冨毅, 仲川清隆

一般財団法人食品分析開発センターSUNATEC メールマガジン　210　2023
ビタミンKによるフェロトーシス抑制作用とビタミンK還元酵素の発見－50年来の謎を解き明かす－

伊藤隼哉, 三島英換, 仲川清隆

バイオサイエンスとインダストリー　81　100-103　2023
22nd IUNS-ICN International Congress of Nutrition in Tokyo に参加して

Isabella Supardi Parida, 伊藤隼哉, 仲川清隆

JMARS News letter　22　13-14　2023
金属イオン付加体を用いた質量分析による脂質構造解析

加藤俊治, 乙木百合香, 仲川清隆

オレオサイエンス　22　287-295　2022
「スペクトロメトリーによる脂質分析の今」の企画と編集にあたって

渡邊慎平, 仲川清隆

オレオサイエンス　22　264　2022
Importance of Nutrition in Japan and the World.

Hisanori Kato, Kiyotaka Nakagawa

The Nutrition Society Gazette, Summer 2022　20　2022
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仲川清隆

オレオサイエンス　22　4　2022/01
東京栄養サミット2021に向けた日本栄養学学術連合の取組について

真鍋祐樹, 瀧本秀美, 仲川清隆

明日の食品産業　12　2021
Foreword Special Issue: International Sympsium on Lipids and Food Ingredients for HEalth Promoton

Kiyotaka Nakagawa

J. Oleo Sci.　21　1529　2021
巻頭言食品成分表勉強会を企画した経緯と思い

仲川清隆

オレオサイエンス　21　443　2021
Revealing the Oxidation Stability and its Mechanism of Rice Bran Oil

加藤俊治, 乙木百合香, RAHMANIA Halida, 仲川清隆

食品と開発　56　(1)　2021

ISSN： 0911-3932
Determination of pyrroloquinoline quinone by Enzymatic and LC-MS/MS methods to clarify its levels in foods

94　(5)　328-332　2020/05
Publisher: 日本ビタミン学会
ISSN： 0006-386X
研究室紹介

加藤俊治, 仲川清隆

ビタミン　94　33-37　2020/02
認知症とプラズマローゲン

乙木百合香, 高橋巧, 加藤俊治, 仲川清隆

日本食品安全協会会誌　15　219-225　2020
Identification of the factor that cause the differential cellular uptake of curcuminoids

板谷麻由子, 宮澤大樹, 仲川清隆

機能性食品と薬理栄養　13　(5)　2020

ISSN： 1348-2564
Evaluating the absorption and metabolism of flavonoids (luteolin): what is required for in vitro tests

仲川清隆, 清水直紀, 加藤俊治

アンチ・エイジング医学　16　(4)　2020

ISSN： 1880-1579
紫外線を浴びたら何を食べる？酸化ストレスと抗酸化食品

加藤俊治, 仲川清隆

現代科学　1　34-37　2020/01
食後高血糖改善成分を含む新規食材の活用桑葉・微生物によるDNJの生産と機能性・安全性の評価

高須蒼生, 木村俊之, 伊藤隼哉, 仲川清隆

化学と生物　58　(1)　13-19　2020/01
Publisher: (公社)日本農芸化学会
ISSN： 0453-073X

eISSN： 1883-6852
健康食品スクアレンの機能性と品質管理

仲川清隆, 清水直紀

アンチエイジング医学　15　572-576　2019/11
Absorption and metabolism of γ-oryzanol, a characteristic functional ingredient in rice bran

Kazue Sawada, Halida Rahmania, Midori Matsuki, Hiroyuki Hashimoto, Junya Ito, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of Nutritional Science and Vitaminology　65　(Supplement)　S180-S184　2019/10

DOI： 10.3177/jnsv.65.S180 　

ISSN： 0301-4800

eISSN： 1881-7742
Significance of squalene in rice bran oil and perspectives on squalene oxidation

Naoki Shimizu, Junya Ito, Shunji Kato, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa

Journal of Nutritional Science and Vitaminology　65　(Supplement)　S62-S66　2019/10

DOI： 10.3177/jnsv.65.S62 　

ISSN： 0301-4800

eISSN： 1881-7742
こめ油と含有されるγ-オリザノールの魅力：機能性表示化の動き

伊藤隼哉, 永塚貴弘, 仲川清隆

アグリバイオ　3　865-867　2019/08
巻頭言

仲川清隆

オレオサイエンス　19　313-313　2019/07
過酸化脂質の構造解析を通じた酸化機構推定：スクアレンの酸化を例にして

清水直紀, 仲川清隆

脂質栄養学　28　40-49　2019/03
「脂質・関連成分分析の新たな潮流」の企画と編集にあたって

白井展也, 仲川清隆

オレオサイエンス　19　42　2019/03
酸化脂質の構造と生体への影響

加藤俊治, 伊藤隼哉, 竹腰進, 仲川清隆

基礎老化研究　43　13-20　2019/02
食用油, 保存に気をつけていますか？ -油脂酸化の化学

加藤俊治, 仲川清隆

化学　74　30-34　2019/01
Potential usability of Amadori-glycated phosphatidylethanolamine as a glycoconjugated biomaterial

Miyazawa, T, Kamiyoshihara, R, Miyazawa, T, Nakagawa, K

IMARS Highlights　13　5-10　2018/04
「最近話題の油脂関連素材」の企画と編集にあたって

白井展也, 仲川清隆

オレオサイエンス　18　90　2018/03
プラズマローゲンの役割と機能: 分子種レベルでの特異的解析が望まれる理由

乙木百合香, 山下慎司, 仲川清隆

機能性食品と薬理栄養　11　(2)　62-68　2017/08
Publisher: (株)インフォノーツパブリッシング
ISSN： 1348-2564
被災地農産物パプリカの機能性の担保に向けてパプリカに含まれるルテオリンの吸収動態の評価

仲川清隆, 早坂夏実, 永塚貴弘, 庄子真樹, 畑中咲子, 津志田藤二郎, 毛利哲

農耕と園藝　9　(9)　18-21　2017/08
Publisher: 誠文堂新光社
ISSN： 1345-8833
New insights into the absorption and metabolism of γ-oryzanol

Kobayashi, E, Ito, J, Shimizu, N, Kato, S, Sawada, K, Matsuki, M, Hashimoto, H, Ikeda, I, Miyazawa, T, Nakagawa, K

The 4th International Conference on Rice Bran Oil 2017 (ICRBO 2017) Proceedings　27-33　2017/08
書評「健康寿命を延ばそう！機能性脂肪酸入門－アルツハイマー病, がん, 糖尿病, 記憶力回復への効果－」

永塚貴弘, 仲川清隆

オレオサイエンス　17　340　2017/07
「こめ油に関する最新の知見」の企画と編集にあたって

仲川清隆

オレオサイエンス　17　252　2017/06
Utilizing phytonutrients for public health and establishing Global Phytonutrient Society (GPS)

Harunobu Amagase, Teruo Miyazawa, Kiyotaka Nakagawa, Shunji Kato

FASEB JOURNAL　31　2017/04

ISSN： 0892-6638

eISSN： 1530-6860
これまでの私の脂質研究（過酸化脂質研究）.

仲川清隆

日本脂質生化学研究サーキュラー 2017　27-28　2017/03
こめ油成分を活用した相乗的ながん抑制効果

永塚貴弘, 西田浩志, 仲川清隆, 宮澤陽夫

オレオサイエンス　17　(6)　261-268　2017
Publisher: 日本油化学会
ISSN： 1345-8949
粉末魚油の開発：過酸化脂質・食品機能性の研究者の視点から.

仲川清隆

第28回水産油脂技術懇話会記録　1-15　2017/01
7種の米糠抽出物によるAroxylラジカル消去反応の速度論的研究：Aroxyl Radical Absorption Capacity (ARAC) Assay法の開発

向井和男, 大内綾, 阿部伎, 村田和優, 仲川清隆, 宮澤陽夫

ビタミンE研究の進歩　17　57-62　2016/12
アルツハイマー型認知症におけるプラズマローゲンの意義

山下慎司, 木下幹朗, 仲川清隆

化学と生物　54　(10)　701-703　2016/09
Publisher: 公益社団法人日本農芸化学会
DOI： 10.1271/kagakutoseibutsu.54.701 　
高吸収化クルクミン製剤の肝機能への作用

小澤瞳, 鷲見芳彦, 仲川清隆, 今泉厚

医学と薬学　73　1047-1055　2016/08
クルクミンの吸収代謝と生理作用発現の関係性

宮澤大樹, 張替敬裕, 仲川清隆

化学と生物　54　500-507　2016/06

DOI： 10.1271/kagakutoseibutsu.54.500 　
ヒト肝癌細胞HepG2細胞におけるホスファチジルコリンヒドロペルオキシドの代謝と毒性

鈴木優里, 仲川清隆, 加藤俊治, 舘脇直人, 水落俊介, 伊藤隼哉, 永塚貴弘, 西田浩志, 宮澤陽夫

ビタミン　90　274-280　2016/05
「脂質分析の新展開」の企画と編集にあたって

仲川清隆

オレオサイエンス　16　212　2016/05
MS/MS, HPLC-MS/MS, キラルHPLC-MS/MSを活用した脂質過酸化機構の評価

伊藤隼哉, 仲川清隆, 加藤俊治, 宮澤陽夫

オレオサイエンス　16　(5)　233-242　2016/05
Publisher: (公社)日本油化学会
ISSN： 1345-8949
生体膜脂質過酸化と細胞老化

加藤俊治, 仲川清隆, 宮澤陽夫

脂質栄養学　25　(1)　25-34　2016/04
Publisher: Japan Society of Lipid Nutrition
DOI： 10.4010/jln.25.25 　

ISSN： 1343-4594

eISSN： 1883-2237
動物試験での絶食, 大丈夫ですか？

伊藤隼哉, 仲川清隆

生物工学会誌　94　(2)　83-83　2016/02
Publisher: (公社)日本生物工学会
ISSN： 0919-3758
Functional analysis of novel rice gene on vitamin E biosynthesis and tocotrienol production

32　283-286　2016
Publisher: 飯島藤十郎記念食品科学振興財団
ISSN： 2188-0662
日本油化学会第54回年会に参加して：博士を目指す女学生の視点から

乙木百合香, 仲川清隆

オレオサイエンス　15　585　2015/12
赤血球キサントフィルの生理的意義 : アルツハイマー病の早期発見と食品成分による予防を目指して

喜古健敬, 仲川清隆, 宮澤陽夫

ニューフードインダストリー　57　(1)　47-55　2015/01
Publisher: 食品資材研究会
ISSN： 0547-0277
「様々な側面からみた脂質・糖代謝」の企画と編集にあたって

仲川清隆

オレオサイエンス　15　4　2015
第87回日本生化学会大会に参加して

伊藤隼哉, 乙木百合香, 仲川清隆

JMARS News Letter　15　6　2015
17th Journal of Oleo Science Editors' Award受賞によせて

都築毅, 栗山慶子, 仲川清隆, 宮澤陽夫

オレオサイエス　14　(8)　349-349　2014/07/01
Publisher: 日本油化学会
Biological roles of Amadori-glycated phosphatidylethanolamine: involvement of lipid glycation in the development of diabetic complications (short review)

K. Nakagawa, F. Kimura, T. Miyazawa

IMARS Highlights　9　5-8　2014/04
タフツ大学半年留学記：クルクミン研究とその後に仙台で半年過ごして

仲川清隆

オレオサイエンス　14　223-224　2014/04
酸化安定性に優れ徐放性が期待できる粉末魚油の開発と展開

青木茂太, 仲川清隆, 半澤康彦, 松本俊介, 阿久津光紹, 宮澤陽夫

冷凍　89　(1041)　483-487　2014
Publisher: 日本冷凍空調学会
ISSN： 0034-3714
「脂溶性ビタミン」の企画と編集にあたって

野上竜一郎, 仲川清隆

オレオサイエンス　14　522　2014
日本油化学会第53回年会に参加して：同時開催された第1回アジアオレオサイエンス会議での研鑽も含めて

加藤俊治, 仲川清隆

オレオサイエンス　14　587　2014
徐放性粉末魚油の製造

青木茂太, 仲川清隆, 宮澤陽夫

FFIジャーナル　218　(4)　325-330　2013/08
Publisher: FFIジャーナル編集委員会
ISSN： 0919-9772
「油脂に関わる新評価法」の企画と編集にあたって

仲川清隆, 白井展也

オレオサイエンス　13　353　2013/08
日本農芸化学会2013年度仙台大会に参加して

上野茂明, 仲川清隆

オレオサイエンス　13　(6)　277-277　2013/06/01
Amadori-glycated phosphatidylethanolamineincreases cellular telomerase activity: A link between diabetes and cancer

T. Eitsuka, K. Nakagawa, H. Nishida

IMARS Highlights　8　24-25　2013
日本過酸化脂質・抗酸化物質学会（旧生体パーオキサイド研究会）第20回年会に参加して

仲川清隆, 木村ふみ子

JMARS News Letter　12　3-4　2012/12
脂質グリケーション産物のLC-MS/MS分析：臨床サンプル測定の必要性

仲川清隆, 澤根健人, 宮澤陽夫

JMARS News Letter　11　5-7　2012/11
特集序言：「カロテノイド研究の最近の話題」の企画と編集にあたって

仲川清隆, 白井展也

オレオサイエンス　12　(10)　482-483　2012/10/01
第103回アメリカ油化学会ポスター発表に参加して

仲川清隆, 井上奈穂

オレオサイエンス　12　(7)　293-294　2012/07/01
特集序言：「油脂・コレステロール研究に関する今日的話題」の企画と編集にあたって

仲川清隆

オレオサイエンス　12　98　2012/02
International Conference and Exhibition on Nutraceuticals and Functional Foods 2011に参加して

仲川清隆, 野坂直久, 山本幸弘

オレオサイエンス　12　38-39　2011/12
特集序言：「過酸化リン脂質の生理的意義」の企画と編集にあたって

仲川清隆

オレオサイエンス　11　11　2011/09
研究室便り：地震と私達

仲川清隆

オレオサイエンス　11　34　2011/07
トコトリエノールによる中性脂肪の改善: 米糠トコトリエノールを利用した肥満になりたくない健康食品の開発に向けて

仲川清隆, Burdeos Gregor Carpentero, 加藤俊治, 小野瀬晋司, 明石直美, 木村ふみ子, 宮澤陽夫

New Food Industry　54　35-43　2011/07
第49回年会第10回油脂優秀論文賞受賞講演会に参加して

仲川清隆

オレオサイエンス　10　479　2010/11
食品キサントフィルによるヒト赤血球脂質酸化の抑制.

仲川清隆, 木村ふみ子, 宮澤陽夫

バイオサイエンスとインダストリー　68　415-417　2010/10
トランス脂肪酸

仲川清隆

Medical View Point　31　8　2010/09
ホヤ(海鞘)プラズマローゲンによる認知症予防に向けた基礎的取り組み

宮澤陽夫, 宮澤大樹, 仲川清隆

Sessile organisms　27　(2)　85-87　2010/08
Publisher: THE SESSILE ORGANISMS SOCIETY OF JAPAN
DOI： 10.4282/sosj.27.85 　

ISSN： 1342-4181
トコトリエノールによるHaCat皮膚角化細胞とヘアレスマウス皮膚の紫外線炎症反応の抑制

柴田央, 仲川清隆, 川上祐生, 都築毅, 宮澤陽夫

ビタミン　84　383-385　2010/06

DOI： 10.20632/vso.84.8_384 　
α-トコフェロールはδ-トコトリエノールのがん細胞増殖抑制作用を弱める

柴田央, 仲川清隆, Phumon Sookwong, 都築毅, 浅井明, 宮澤陽夫

ビタミン　84　(10)　487-489　2010/06
Publisher: THE VITAMIN SOCIETY OF JAPAN
DOI： 10.20632/vso.84.10_487 　

ISSN： 0006-386X
カロテノイドによる生体脂質過酸化の制御:赤血球膜過酸化の抑制とアルツハイマー病予防の可能性

仲川清隆, 宮澤大樹, 喜古健敬, 宮澤陽夫

機能性食品と薬理栄養　6　123-130　2010/05
海産プラスマローゲンによる認知症予防に向けた基礎的取組み

宮澤大樹, 山下慎司, 仲川清隆, 宮澤陽夫

FOOD STYLE 21　14　29-31　2010/04
認知症および血管新生病に対するビタミンＥの改善効果

Sookwong Phumon, 宮澤大樹, 仲川清隆, 宮澤陽夫

Functional Food　3　(3)　253-258　2010/03
Publisher: フジメディカル出版
ISSN： 1882-3971
The 1st International Conference on Lipid Hydroperoxide Biology and Medicine Sendai 2009 (ICLH2009) Joint Meeting of The 17th Annual Meeting of Japan Society for Lipid Hydroperoxide Biology and Medicine 2009 第1回国際生体パーオキサイド研究会に参加して

仲川清隆

JMARS News Letter　8　3-4　2010/01
食品トコトリエノールの新たな機能性について

柴田央, 仲川清隆, 宮澤陽夫

New Food Industry　9　40-51　2009/08
栄養生理作用解明のための食品と生体成分の分析法開発

仲川清隆

日本栄養・食糧学会誌　62　(3)　113-121　2009/06
Publisher: Japan Society of Nutrition and Food Science
DOI： 10.4327/jsnfs.62.115 　

ISSN： 0287-3516

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Despite an increasing number of nutritional studies on food constituents, there has been some difficulty in assessing their bioavailability in human studies. In many cases, biological evaluation has been limited by a lack of proper analytical methods. In this paper, analytical techniques for glycated lipids (newly suggested to be pathogenetic agents) and food components (e.g., tea catechins), for which micro-analysis has been shown to be difficult, were introduced, and their application to nutritional studies was discussed.
擬似移動層クロマトグラフィー適用による米油製造残渣からの高純度トコトリエノール製造技術の開発

木村俊之, 仲川清隆, 宮澤陽夫

農林水産技術研究ジャーナル　2009

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トコトリエノールの抗血管新生作用とその機構

柴田央, 仲川清隆, 宮澤陽夫

VITAMINS　83　(1)　21-23　2009/01
Publisher: THE VITAMIN SOCIETY OF JAPAN
DOI： 10.20632/vso.83.1_21 　

ISSN： 0006-386X
最近の文献紹介

仲川清隆

JMARS News Letter　7　6-7　2009/01
桑成木の移植による実験桑園造成と生育状況

大村道明, 小倉振一郎, 堀雅敏, 中野俊樹, 仲川清隆, 川島滋和, 結城眞, 佐藤伸洋, 小野隆夫, 鈴木秀人, 田中繁史, 中鉢広, 狩野広, 遊佐健司, 遊佐良一, 遊佐文博

複合生態フィールド教育研究センター報告　24　(24)　19-28　2008/12
Publisher: 東北大学大学院農学研究科附属複合生態フィールド教育研究センター
Glycation of plasma lipoprotein lipid membrane and screening for lipid glycation inhibitor International-journal

Kiyotaka Nakagawa, Daigo Ibusuki, Shinji Yamashita, Teruo Miyazawa

Annals of the New York Academy of Sciences　1126　288-290　2008/04

DOI： 10.1196/annals.1433.032 　

ISSN： 0077-8923

eISSN： 1749-6632
Analysis of Amadori-glycated phosphatidylethanolamine in the plasma of healthy subjects and diabetic patients by liquid chromatography-tandem mass spectrometry International-journal

Teruo Miyazawa, Daigo Ibusuki, Shinji Yamashita, Kiyotaka Nakagawa

Annals of the New York Academy of Sciences　1126　291-294　2008/04

DOI： 10.1196/annals.1433.033 　

ISSN： 0077-8923

eISSN： 1749-6632
血糖値改善効果を有する桑葉製品開発

宮澤陽夫, 木村俊之, 仲川清隆

FOOD STYLE 21　12　(8)　24-26　2008
Publisher: 食品化学新聞社
ISSN： 1343-9502
糖尿病の急増と桑園の遊休化対策としての桑成分の機能性食材化

宮澤陽夫, 木村俊之, 仲川清隆

New Food Industry　50　(12)　61-68　2008
Publisher: 食品資材研究会
ISSN： 0547-0277
Anti-angiogenic function of tocotrienol International-journal

Teruo Miyazawa, Akira Shibata, Kiyotaka Nakagawa, Tsuyoshi Tsuzuki

Asia Pacific Journal of Clinical Nutrition　17　(SUPPL. 1)　253-256　2008/01

ISSN： 0964-7058
血糖値改善効果を有する桑葉の製品開発 (第3報)

関澤春仁, 後藤裕子, 高久明美, 室井梨沙子, 河野圭助, 宮澤陽夫, 仲川清隆, 木村俊之, 土井則夫, 野木照修, 小島芳弘

福島県ハイテクプラザ試験研究報告　2006　33-35　2007/09

ISSN： 0919-6676
学会見聞記２００７年日本農芸化学会大会

小林厚志, 永田裕二, 大崎雄介, 白川仁, 仲川清隆, 日出間志寿

バイオサイエンスとインダストリー　65　(7)　360-363　2007/07/01
Publisher: （財）バイオインダストリー協会
ISSN： 0914-8981
抗血管新生作用を有するトコトリエノールの高生産イネの作出

仲川清隆, 柴田央, Phumon Sookwong, 宮澤陽夫, 村田和優

化学と生物　45　(1)　11-13　2007
Publisher: 日本農芸化学会
ISSN： 0453-073X
2007年度日本農芸化学会大会（学会見聞記）

小林厚志, 永田裕二, 大崎雄介, 白川仁, 仲川清隆, 日出間志寿

バイオサイエンスとインダストリー　65　34-38　2007
水産油脂由来の機能成分-その健康への役割-

仲川清隆

JMOA　1-15　2007
第15 回生体パーオキサイド研究会に参加して

仲川清隆

JMARS News Letter　4　2　2007
Current Topics in Food and Biodynamic Chemistry Research

T. Miyazawa, Y. Kawakami, T. Kimura, Y. Suzuki, S. Yamashita, R. Abe, D. Ibusuki, P. Sookwong, T. Tsuzuki, F. Kimura, K. Nakagawa

Tohoku Journal of Agricultural Research　57　(1)　33-54　2006/11

ISSN： 0040-8719
Angiogenic potency of Amadori-glycated phosphatidylethanolamine International-journal

Kiyotaka Nakagawa, Jeong Ho Oak, Teruo Miyazawa

Annals of the New York Academy of Sciences　1043　413-416　2005

DOI： 10.1196/annals.1333.048 　

ISSN： 0077-8923
Tandem mass spectrometry analysis of Amadori-glycated phosphatidylethanolamine in human plasma International-journal

Teruo Miyazawa, Jeong Ho Oak, Kiyotaka Nakagawa

Annals of the New York Academy of Sciences　1043　280-283　2005

DOI： 10.1196/annals.1333.034 　

ISSN： 0077-8923
A convenient method for preparation of high-purity, Amadori-glycated phosphatidylethanolamine and its prooxidant effect International-journal

Teruo Miyazawa, Jeong Ho Oak, Kiyotaka Nakagawa

Annals of the New York Academy of Sciences　1043　276-279　2005

DOI： 10.1196/annals.1333.033 　

ISSN： 0077-8923
Anti-angiogenic potential of tocotrienol in vitro

T. Miyazawa, H. Inokuchi, H. Hirokane, T. Tsuzuki, K. Nakagawa, M. Igarashi

Biochemistry (Moscow)　69　(1)　67-69　2004/01

DOI： 10.1023/B:BIRY.0000016353.18007.39 　

ISSN： 0006-2979
Antiangiogenic potency of vitamin E International-journal

Teruo Miyazawa, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Miki Igarashi

Annals of the New York Academy of Sciences　1031　401-404　2004

DOI： 10.1196/annals.1331.057 　

ISSN： 0077-8923
Simple and rapid determination of 1-deoxynojirimycin in mulberry leaves International-journal

Toshiyuki Kimura, Kiyotaka Nakagawa, Yuko Saito, Kenji Yamagishi, Masahiro Suzuki, Kohji Yamaki, Hiroshi Shinmoto, Teruo Miyazawa

BioFactors　22　(1-4)　341-345　2004

DOI： 10.1002/biof.5520220167 　

ISSN： 0951-6433
Dual mechanisms for telomerase inhibition in DLD-1 human colorectal adenocarcinoma cells by polyunsaturated fatty acids International-journal

Takahiro Eitsuka, Kiyotaka Nakagawa, Teruo Miyazawa

BioFactors　21　(1-4)　19-21　2004

DOI： 10.1002/biof.552210105 　

ISSN： 0951-6433
DNA chip analysis of comprehensive food function: Inhibition of angiogenesis and telomerase activity with unsaturated vitamin E, tocotrienol International-journal

Kiyotaka Nakagawa, Takahiro Eitsuka, Hitoshi Inokuchi, Teruo Miyazawa

BioFactors　21　(1-4)　5-10　2004

DOI： 10.1002/biof.552210102 　

ISSN： 0951-6433
Amadori-glycated phosphatidylethanolamine induces lipid peroxidation in membrane model

M Yamada, JH Oak, K Nakagawa, T Miyazawa

MAILLARD REACTION IN FOOD CHEMISTRY AND MEDICAL SCIENCE: UPDATE FOR THE POSTGENOMIC ERA　1245　(C)　61-64　2002

DOI： 10.1016/S0531-5131(02)01025-7 　

ISSN： 0531-5131
The Maillard Reaction in Food Chemistry and Medical Science: Update for The Postgenomic Era - International Congress series 1245(1)

T. Miyazawa, J.-H. Oak, M. Yamada, K. Nakagawa

The Maillard Reaction in Food Chemistry and Medical Science: Update for The Postgenomic Era - International Congress series 1245(1)　1245　(C)　285-288　2002/01
Publisher: Excerpta Medica
DOI： 10.1016/S0531-5131(02)00911-1 　

ISSN： 0531-5131
脂質のグリケーション産物は糖尿病診断を変えるか？

玉正浩, 仲川清隆

化学と生物　39　(5)　322-323　2001/04
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
DOI： 10.1271/kagakutoseibutsu1962.39.322 　

ISSN： 0453-073X
天然抗酸化物質の吸収と代謝

宮澤陽夫, 仲川清隆, 浅井明

化学と生物　38　(2)　104-114　2000/12
Publisher: Japan Society for Bioscience, Biotechnology, and Agrochemistry
DOI： 10.1271/kagakutoseibutsu1962.38.104 　

ISSN： 0453-073X

eISSN： 1883-6852
カテキンの抗酸化作用

仲川清隆, 宮澤陽夫

食の科学　10　(272)　44-51　2000/09
Evaluation of Autioxidant Activity of Natural Products

宮澤陽夫, 仲川清隆

J. Jpn. Oil Chem. Soc.　47　(10)　1073-1082　1998/10
Publisher: 日本油化学会
DOI： 10.5650/jos1996.47.1073 　

ISSN： 1341-8327

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The methods for evaluating antioxidant property of natural products in in vitro and in vivo lipid peroxidation systems are reviewed. Antioxidant activity of tocopherols, carotenoids, flavonoids and curcuminoids have been demonstrated against lipid peroxidation induced in microsomes, erythrocytes, plasma lipoproteins and in animal trials. Recently, in vivo antioxidant function of natural products was extensively investigated in humans together with explanation of their absorbability and metabolic fate.
Recent Advances in Gastroenterological Carcinogenesis I

H. Matsumoto, T. Yamane, N. Kikuoka, H. Nakatani, Y. Iwata, K. Oya, T. Takahashi, H. Tokuda, H. Nishino, K. Nakagawa, T. Miyazawa

1996/01
Publisher: Monduzzi Editore S. p. A., Bologna, Italy

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Books and Other Publications 45

豆類の百科事典

伊藤隼哉, 清水直紀, 仲川清隆

2024
豆類の百科事典

清水直紀, 伊藤隼哉, 仲川清隆

2024
米の機能性食品化と新規利用技術・高度加工技術の開発

伊藤隼哉, 小林エリ, 仲川清隆

2022
ビタミン・バイオファクター総合辞典

仲川清隆, 木村俊之, 木村映一

2021
医薬品/化粧品/食品分野におけるHPLC・GC分析テクニック

加藤俊治, 仲川清隆

（株）技術情報協会　2020/06
茶ポリフェノールの生理機能と応用展開

仲川清隆, 小林誠

シーエムシー出版　2019/11
宮城の医療と健康

仲川清隆

河北新報社, 84-86 (2019)　2019/10
認知症と機能性食品―最新動向とその可能性

宮澤大樹, 仲川清隆, 宮澤陽夫

フジメディカル出版　2018/11
食品機能性脂質の基礎と応用

阿久津光紹, 仲川清隆

シーエムシー出版　2018/06
食品機能性成分の吸収・代謝・作用機序

澤田一惠, 松木翠, 橋本博之, 仲川清隆

シーエムシー出版　2018/04
茶の事典

仲川清隆, 宮澤陽夫

朝倉書店　2017
メイラード反応の機構・制御・利用

伊藤隼哉, 仲川清隆

シーエムシー出版　2016/04
新版基礎食品学

仲川清隆, 宮澤陽夫

アイ・ケイコーポレーション　2015/12
栄養・食糧学用語辞典第2版

仲川清隆

建帛社　2015
栄養・食糧学用語辞典第2版

仲川清隆

建帛社　2015
食品因子による栄養機能制御

仲川清隆, 宮澤陽夫

建帛社　2015
アンチエイジングのための100の質問

木村ふみ子, 仲川清隆, 宮澤陽夫

メディカルレビュー社　2014
Handbook of Food Fortification and Health: From Concepts to Public Health Application

K. Nakagawa, P. Sookwong, T. Miyazawa

Kings College London, UK　2013/10/10
食品機能性成分の吸収・代謝機構

仲川清隆

シーエムシー出版　2013/05
ガングリオシド. 油脂・脂質・界面活性剤データブック

菅原達也, 宮澤陽夫

丸善出版株式会社　2012/12/28
Vitamin E Beyond Tocopherols, Second edition,

Takahiro Eitsuka, Kiyotaka Nakagawa, Teruo Miyazawa

CRC Press Taylor & Francis Group LLC　2012/10/10
Food and Nutritional Components in Focus No. 1. Vitamin A and Carotenoids: Chemistry, Analysis, Function and Effects

Taiki Miyazawa, Kiyotaka Nakagawa, Teruo Miyazawa

The Royal Society of Chemistry　2012/08/30
エイコサペンタエン酸 (EPA). 機能性食品の作用と安全性百科

木村ふみ子, 仲川清隆

丸善出版株式会社　2012/07/21
Q10, ユビキノン, ビタミンQ. 機能性食品の作用と安全性百科

仲川清隆

丸善出版株式会社　2012/07/21
ジアシルグリセロール. 機能性食品の作用と安全性百科

仲川清隆

丸善出版株式会社　2012/07/21
植物ステロール. 機能性食品の作用と安全性百科

井上奈穂, 仲川清隆

丸善出版株式会社　2012/07/21
ドコサヘキサエン酸 (DHA). 機能性食品の作用と安全性百科

木村ふみ子, 仲川清隆

丸善出版株式会社　2012/07/21
ビタミンC. 機能性食品の作用と安全性百科

仲川清隆

丸善出版株式会社　2012/07/21
ビタミンD. 機能性食品の作用と安全性百科

上野茂昭, 仲川清隆

丸善出版株式会社　2012/07/21
ビタミンE. 機能性食品の作用と安全性百科

永塚貴弘, 仲川清隆

丸善出版株式会社　2012/07/21
ビタミンK. 機能性食品の作用と安全性百科

白川仁, 後藤知子, 仲川清隆

丸善出版株式会社　2012/07/21
Cancer prevention by rice bran tocotrienol, “Rice Studies, Present and Future”

Miyazawa Teruo, Shibata Akira, Nakagawa Kiyotaka, Sookwong Phumon

Sankyo Publishing Co.(Tokyo)　2012

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ISBN978-4-7827-0665-7
食品の機能化学

宮澤陽夫, 五十嵐修, 分担執筆者, 仲川清隆ら

アイ・ケイコーポレーション　2010/04
食品機能性の科学

宮澤陽夫, 仲川清隆

産業技術サービスセンター　2008/12

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西川研次郎監修
Tocotrienols Vitamin E: Beyond Tocopherols.

K. Nakagawa, A. Shibata, P. Sookwong, T. Miyazawa

CRC Press　2008/09
Tocotrienols Vitamin E: Beyond Tocopherols

K. Nakagawa, A. Shibata, P. Sookwong, T. Miyazawa

CRC Press　2008/09
アンチエイジング・ヘルスフード

仲川清隆, 庄子真樹, 宮澤陽夫

サイエンスフォーラム　2008/01/21
Bromacology: Pharmacology of Foods and Their Components

A. Shibata, S. Yamashita, K. Nakagawa, T. Miyazawa

2008
食品の安全性及び機能性に関する総合研究ー機能性ー

仲川清隆, 宮澤陽夫

農林水産省農林水産技術会議事務局　2008/01
Dietary Fats and Risk of Chronic Disease

T. Miyazawa, S. Kanno, T. Eitsuka, K. Nakagawa

Amer. Oil Chem. Soc. (AOCS) Press　2006

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Ed by Y.S. Huang, T. Yanagita, H. Knapp
脂質栄養と健康

宮澤陽夫, 仲川清隆

建帛社　2005/05
Asian Functional Foods

T. Miyazawa, K. Nakagawa

CRC Press, USA　2005/01
茶の機能：生体機能の新たな可能性

仲川清隆, 宮澤陽夫

学会出版センター　2002/04

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村松、小國、伊勢村、杉山、山本編
食品機能研究法

仲川清隆, 宮澤陽夫

光琳　2000/05

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上野川、篠原、鈴木編
Food for Health in the Pacific Rim

T. Miyazawa, K. Nakagawa

Food & Nutrition Press, INC., Trumbull, Connecticut　1999/10

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ed by J.R. Whitaker et al

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Media Coverage 26

築野食品工業株式会社、東京大学との共同研究で令和6年度日本油化学会工業技術賞

東北大学農学研究科HP

2025/04
食や体に作用「酸化」研究

読売新聞オンライン

2025/02
植物油の酸化原因を瞬時に見極める手法を開発、Food Chemistryに掲載

東北大学農学研究科HP

2024/11
ドイツ・ヘルムホルツセンターミュンヘンとの国際共同研究成果「フェロトーシス感受性を制御するセレン運搬タンパク質の同定」がMolecular Cellに掲載

東北大学HP

2024/11
第62回日本油化学会年会の発表に関する紹介記事

健康産業流通新聞

2024/09
一般財団法人日本食品分析センターとの共同研究成果が、Scientific Reportsに掲載

東北大学農学研究科HP

2024/08
J-オイルミルズ食用油脂の劣化抑制東北大との共同研究が受賞

食品新聞

2024/06
2023年BBB論文賞を受賞

東北大学農学研究科HP

2024/04
ドイツ・ヘルムホルツセンターミュンヘン、東北大学大学院医学系研究科との国際共同研究成果

東北大学HP

2024/04
自治医科大学、ドイツ・ヘルムホルツミュンヘンとの国際共同研究成果がNature Communicationsに掲載

東北大HP 農学研究科HP

2024/03
株式会社 J-オイルミルズとの共同研究講座の延長が決定

東北大学HP 農学研究科HP J-オイルミルズHP

2024/03
ドイツ・ヘルムホルツセンターミュンヘン、東北大学大学院医学系研究科との国際共同研究成果がCell Reports Methodsに掲載

東北大HP 農学研究科HP

2024/02
日清オイリオグループ株式会社との共同研究成果がFood Chemistry:Xに掲載

東北大学HP 農学研究科HP 日経電子版

2024/01
お米の未来を考えるシンポジウムが紹介されました

油業報知新聞油脂版

2024/01
お米の未来を考えるシンポジウムが紹介されました

健康産業流通新聞

2024/01
研究成果がFood Research Internationalに掲載

農学研究科HP

2023/12
お米の未来を考えるシンポジウムが紹介されました

日刊油脂特報第18705

2023/12
日清オイリオグループ株式会社と「脂質酸化による美味しさ及び健康への影響」をテーマにシンポジウムを開催

プレスリリース

2023/10
横浜油脂工業株式会社との共同研究成果

ニュースリリース

2023/04
22nd IUNS-ICN International Congress of Nutrition（第22回国際栄養学会議）の運営に関する紹介記事

公益財団法人東京観光財団

2023
22nd IUNS-ICN International Congress of Nutrition（第22回国際栄養学会議）の運営に関する紹介記事

Businessevents Tokyo

2023
私たちの研究室が紹介されました

ぶんせき, 3, 115-116

2023
研究成果がRedox Biologyに掲載

農学研究科HP

2022/10
カルビー株式会社との共同研究成果

ニュースリリース

2022/10
国際共同研究成果がNatureに掲載

東北大HP 農学研究科HP

2022/08
東北大学大学院農学研究科との共同研究講座油脂の劣化指標「酸価」新たな上昇経路を証明“フライ食品のおいしさ長持ち” “環境負荷低減” 実現へ

プレスリリース

2022/07

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