Details of the Researcher

PHOTO

Katsunori Nonogaki
Section
Research Center for Accelerator and Radioisotope Science
Job title
Professor
Degree

  • 博士（医学）（名古屋大学）

Profile

Dr. Nonogaki has worked as a Postdoc Research Fellow at the University of California, San Francisco and the Scripps Research Institute, La Jolla. He has studied central serotonin network in the regulation of appetite and energy homeostasis. Lorcaserin (Belviq), a selective 5-HT2C receptor agonist, which is used for the treatment of obesity, is based on the original research works by Dr. Nonogaki et al. Current studies are to determine the network of gut-derived hormones and liver-derived hormones in the regulation of obesity and type 2 diabetes. Dr. Nonogaki also has a novel ultrasound irradiation device for hypertension and diabetes.

Committee Memberships 6

  • 日本心身医学会　代議員

    - Present

  • 日本糖尿病協会　糖尿病認定医

    - Present

  • 日本内分泌学会　評議員

    - Present

  • 日本糖尿病学会　研修指導医・専門医

    - Present

  • 日本内科学会　総合内科専門医

    - Present

  • 日本老年医学会　評議員

    - 2014

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Professional Memberships 8

  • American Diabetes Association

  • Society for Neuroscience

  • THE JAPAN GERIATRICS SOCIETY

  • JAPAN SOCIETY FOR THE STUDY OF OBESITY

  • JAPANESE SOCIETY OF PSYCHOSOMATIC MEDICINE

  • The Japan Endocrine Society

  • THE JAPAN DIABETES SOCIETY

  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

︎Show all ︎Show first 5

Research Interests 43

  • MAFLD、MASH

  • glucagon

  • GIP

  • TPH

  • Tryptophan

  • FGF15

  • whey protein

  • 5-HT receptor

  • GLP-1 receptor

  • autonomic nervous system

  • eating behavior

  • appetite

  • Hypertension

  • ultrasound

  • Diet

  • Type 2 diabetes

  • obesity

  • serotonin

  • 臨床栄養

  • 分子栄養

  • 食行動

  • 神経ペプチド

  • 神経薬理

  • 食事療法

  • ストレス

  • 臓器間ネットワーク

  • GLP-1受容体

  • セロトニン

  • グレリン

  • へパトカイン

  • 中枢神経系

  • EPA

  • 超音波治療

  • 高血圧

  • 2型糖尿病

  • 脂質代謝

  • エネルギー代謝

  • 肥満

  • 自律神経系

  • FGF21

  • セロトニン受容体

  • GLP-1

  • 食欲調節

Research Areas 12

  • Life sciences / Pharmacology /

  • Other / Other / Laboratory medicine

  • Life sciences / Clinical pharmacy /

  • Life sciences / Physiology /

  • Life sciences / Internal medicine - General /

  • Humanities & social sciences / Home economics, lifestyle science /

  • Life sciences / Metabolism and endocrinology /

  • Life sciences / Cardiology / Hypertension, Atherosclerosis

  • Life sciences / Neuroscience - general / Appetite、Autonomic nervous system

  • Life sciences / Biomaterials / Ultrasound irradiation device

  • Life sciences / Biomedical engineering / Ultrasound irradiation device

  • Life sciences / Metabolism and endocrinology / Diabetes, Metabolism, Endocrinology, Neuroscience

Awards 2

  1. Best Researcher Award/International Cognitive Scientist Awards

    2024/09　International Cognitive Scientist Awards　a renowned neuroscientist and clinical specialist in diabetes and internal medicine,

  2. 東北地方発明表彰（宮城県発明協会）「発明奨励賞」

    2023/10

Papers 93

  1. Tryptophan Hydroxylase 1 Regulates Tryptophan and Its Metabolites Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    International Journal of Molecular Sciences　26　(9)　3978-3978　2025/04/23

    Publisher: MDPI AG

    DOI： 10.3390/ijms26093978 　

    eISSN： 1422-0067

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    Tryptophan hydroxylase (Tph), the rate-limiting enzyme of serotonin (5-hydroxytryptophan; 5-HT) synthesis, exists in two isoforms, Tph1 and Tph2. Tph1 upregulates peripheral 5-HT synthesis and blood 5-HT levels, whereas Tph2 upregulates brain 5-HT synthesis. Here, we show that plasma and brain levels of tryptophan and its metabolites, including 5-HT, 5-hydroxy indoleacetic acid, indolepropionic acid, indole-3-acetic acid, kynurenine, and xanthurenic acid, are decreased in young (8-week-old) Tph1-mutant mice compared with age-matched wild-type mice. In older (7-month-old) Tph1-mutants, the decreases in tryptophan and its metabolites outside the 5-HT pathway were diminished. Although single-housed Tph1 mutants displayed age-related alterations in food intake, body weight, and plasma FGF21 levels, blood glucose levels were lower in both young and older Tph1 mutants compared with age-matched wild-type mice. These findings suggest that Tph1 regulates tryptophan and its metabolites in the plasma and brain, as well as blood glucose homeostasis.

  2. Editorial: Insights in obesity: 2023. Invited Peer-reviewed

    Katsunori Nonogaki

    Front Endocrinol (Lausanne)　15　1489087　2024/11/13

    DOI： 10.3389/fendo.2024.1489087 　

  3. "The GLP-1 Receptor Agonist Liraglutide Decreases Primary Bile Acids and Serotonin in the Colon Independently of Feeding in Mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    International Journal of Molecular Sciences　25　(14)　7784　2024/07/16

    DOI： 10.3390/ijms25147784 　

  4. Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    Frontiers in Endocrinology　14　1080790.　2023/01/27

    Publisher: Frontiers Media SA

    DOI： 10.3389/fendo.2023.1080790. 　

    eISSN： 1664-2392

    More details Close

    Farnesoid X receptor (FXR) and Takeda G protein-coupled Receptor 5 (TGR5), the intestinal bile acid (BA) receptors, regulate the gut-derived hormones including fibroblast growth factor 15/19 (FGF15/19) and serotonin (5-hydrooxytryptamine, 5-HT). Here we show that ingestion of whey protein isolate, a milk protein, significantly decreased expression of heteromeric organic solute transporter Ostα and Ostβ, which is the basolateral BA transporter in the enterocyte, and increased the expression of FXR and FGF15 in C57BL6J mouse ileum and plasma FGF15 levels. In addition, the ingestion of whey protein isolate significantly suppressed expression of hepatic cholesterol-7α hydroxylase (CYP7A1), which induces the primary BA synthesis, bile salt export pump (BSEP) and sodium-taurocholate cotransporting polypeptide (NTCP), which are the key transporters for the BA excretion and uptake in the liver, and genes involved in gluconeogenesis, and decreased the primary BAs including cholic acid, taurocholic acid, glycocholic acid, and taurochenodeoxycholic acid in the liver compared with controls. Moreover, ingestion of whey protein isolate significantly decreased the expression of TGR5, glucagon-like peptide 1 (GLP-1), and tryptophan hydroxylase1 (Tph1) in the small intestine, leading to decreases in plasma 5-HT and insulin levels. On the other hand, ingestion of the soy protein β-conglycinin significantly increased the expression of Ostα and Ostβ, and decreased the expression of FGF15 in the ileum and plasma FGF15 levels, leading to the increases in expression of hepatic CYP7A1, BSEP, NTCP, and genes involved in gluconeogenesis, and the primary BAs in the liver. Moreover, ingestion of β-conglycinin significantly increased the expression of intestinal TGR5, GLP-1, and Tph1, leading to increases in plasma 5-HT and insulin levels. These findings suggest that whey protein and β-conglycinin have opposite effects on intestinal FGF15 and 5-HT secretion in mice.

  5. The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases. International-journal Peer-reviewed

    Katsunori Nonogaki

    International journal of molecular sciences　23　(3)　2022/01/29

    DOI： 10.3390/ijms23031600 　

    More details Close

    Central and peripheral serotonin (5-hydroxytryptamine, 5-HT) regulate feeding signals for energy metabolism. Disruption of central 5-HT signaling via 5-HT2C receptors (5-HT2CRs) induces leptin-independent hyperphagia in mice, leading to late-onset obesity, insulin resistance, and impaired glucose tolerance. 5-HT2CR mutant mice are more responsive than wild-type mice to a high-fat diet, exhibiting earlier-onset obesity and type 2 diabetes. High-fat and high-carbohydrate diets increase plasma 5-HT and fibroblast growth factor-21 (FGF21) levels. Plasma 5-HT and FGF21 levels are increased in rodents and humans with obesity, type 2 diabetes, and non-alcohol fatty liver diseases (NAFLD). The increases in plasma FGF21 and hepatic FGF21 expression precede hyperinsulinemia, insulin resistance, hyperglycemia, and weight gain in mice fed a high-fat diet. Nutritional, pharmacologic, or genetic inhibition of peripheral 5-HT synthesis via tryptophan hydroxylase 1 (Tph1) decreases hepatic FGF21 expression and plasma FGF21 levels in mice. Thus, perturbing central 5-HT signaling via 5-HT2CRs alters feeding behavior. Increased energy intake via a high-fat diet and/or high-carbohydrate diet can upregulate gut-derived 5-HT synthesis via Tph1. Peripheral 5-HT upregulates hepatic FGF21 expression and plasma FGF21 levels, leading to metabolic diseases such as obesity, insulin resistance, type 2 diabetes, and NAFLD. The 5-HT network in the brain-gut-liver axis regulates feeding signals and may be involved in the development and/or prevention of metabolic diseases.

  6. Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    Heliyon　6　(12)　e05774-e05774　2020/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.heliyon.2020.e05774 　

    ISSN： 2405-8440

  7. Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    Scientific Reports　(10)　15784　2020/09/25

  8. Low-frequency and low-intensity ultrasound increases cardiac parasympathetic neural activity and decreases clinic hypertension in elderly hypertensive subjects with type 2 diabetes Peer-reviewed

    Katsunori Nonogaki, Mari Murakami, Tomoe Yamazaki, Naohiko Nonogaki

    IJC Heart and Vasculature　19　34-36　2018/06/01

    Publisher: Elsevier Ireland Ltd

    DOI： 10.1016/j.ijcha.2018.04.002 　

    ISSN： 2352-9067

  9. Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    Journal of Diabetes Research　2018　6482958　2018

    Publisher: Hindawi Limited

    DOI： 10.1155/2018/6482958 　

    ISSN： 2314-6753 2314-6745

  10. A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice Peer-reviewed

    Nonogaki K, Kaji T, Murakami M

    Neuropsychiatry　8　(4)　1476-1481　2018

  11. A Tryptophan Hydroxylase Inhibitor Decreases Hepatic FGF21 Expression and Circulating FGF21 in Mice Fed A High-Fat Diet Peer-reviewed

    Nonogaki K, Kaji T, Murakami M

    Neuropsychiatry　8　(1)　372-377　2018

  12. Low-frequency and low-intensity ultrasound irradiation to the forearm improves an index of arterial stiffness in subjects with type 2 diabetes and hypertension Peer-reviewed

    Katsunori Nonogaki, Mari Murakami, Tomoe Yamazaki, Naohiko Nonogaki

    IJC Heart and Vasculature　16　4-6　2017/09/01

    Publisher: Elsevier Ireland Ltd

    DOI： 10.1016/j.ijcha.2017.08.001 　

    ISSN： 2352-9067

  13. alpha 1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    NEUROSCIENCE LETTERS　638　35-38　2017/01

    DOI： 10.1016/j.neulet.2016.12.008 　

    ISSN： 0304-3940

    eISSN： 1872-7972

  14. Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKA(y) mice Peer-reviewed

    K. Nonogaki, T. Kaji, T. Yamazaki, Mari Murakami

    NUTRITION & DIABETES　6　2016/11

    DOI： 10.1038/nutd.2016.41 　

    ISSN： 2044-4052

  15. The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    DIABETES RESEARCH AND CLINICAL PRACTICE　120　186-189　2016/10

    DOI： 10.1016/j.diabres.2016.08.009 　

    ISSN： 0168-8227

    eISSN： 1872-8227

  16. Low-frequency and very low-intensity ultrasound decreases blood pressure in hypertensive subjects with type 2 diabetes Peer-reviewed

    Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Noriko Satoh, Miki Hazama, Kouji Takeda, Nobuyuki Tsujita, Shuichi Katoh, Nariki Kubota

    INTERNATIONAL JOURNAL OF CARDIOLOGY　215　147-149　2016/07

    DOI： 10.1016/j.ijcard.2016.04.062 　

    ISSN： 0167-5273

    eISSN： 1874-1754

  17. Decreased energy intake versus increased lipolysis in the prevention of type 2 diabetes. Peer-reviewed

    Nonogaki K

    Integr Obesity Diabetes.　2　(5)　1-1　2016

  18. Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting Peer-reviewed

    Katsunori Nonogaki, Takao Kaji, Tomoe Yamazaki, Mari Murakami

    NEUROSCIENCE LETTERS　612　14-17　2016/01

    DOI： 10.1016/j.neulet.2015.12.011 　

    ISSN： 0304-3940

    eISSN： 1872-7972

  19. Gut microbiota-induced 5-HT synthesis and obesity. Peer-reviewed

    Nonogaki K

    J. Endocrinology and Diabetes　1-1　2015/12

  20. Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    DIABETES RESEARCH AND CLINICAL PRACTICE　110　(3)　E18-E21　2015/12

    DOI： 10.1016/j.diabres.2015.10.011 　

    ISSN： 0168-8227

    eISSN： 1872-8227

  21. Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice Peer-reviewed

    K. Nonogaki, T. Kaji

    DIABETES & METABOLISM　41　(5)　425-428　2015/11

    DOI： 10.1016/j.diabet.2015.06.005 　

    ISSN： 1262-3636

    eISSN： 1878-1780

  22. Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKA(y) mice Peer-reviewed

    Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Takao Kaji

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　464　(2)　674-677　2015/08

    DOI： 10.1016/j.bbrc.2015.07.058 　

    ISSN： 0006-291X

    eISSN： 1090-2104

  23. Neural Control of Energy Balance: Translating Circuits to Therapies Peer-reviewed

    Laurent Gautron, Joel K. Elmquist, Kevin W. Williams

    CELL　161　(1)　133-145　2015/03

    DOI： 10.1016/j.cell.2015.02.023 　

    ISSN： 0092-8674

    eISSN： 1097-4172

  24. Gut microbiota and glucose homeostasis. Peer-reviewed

    Nonogaki K

    J. Diabetes and Obesity.　2　(4)　1-2　2015

  25. Liraglutide Suppresses Obesity and Hyperglycemia Associated with Increases in Hepatic Fibroblast Growth Factor 21 Production in KKA(y) Mice Peer-reviewed

    Katsunori Nonogaki, Miki Hazama, Noriko Satoh

    BIOMED RESEARCH INTERNATIONAL　2014　751930　2014

    DOI： 10.1155/2014/751930 　

    ISSN： 2314-6133

    eISSN： 2314-6141

  26. Bach1 deficiency protects pancreatic beta-cells from oxidative stress injury Peer-reviewed

    Keiichi Kondo, Yasushi Ishigaki, Junhong Gao, Tetsuya Yamada, Junta Imai, Shojiro Sawada, Akihiko Muto, Yoshitomo Oka, Kazuhiko Igarashi, Hideki Katagiri

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM　305　(5)　E641-E648　2013/09

    DOI： 10.1152/ajpendo.00120.2013 　

    ISSN： 0193-1849

  27. Low-frequency and very low-intensity ultrasound decreases blood pressure in subjects with hypertension Peer-reviewed

    Katsunori Nonogaki, Marina Suzuki, Marin Sanuki, Naohiko Nonogaki, Kouji Takeda, Nobuyuki Tsujita, Shuichi Katoh, Nariki Kubota

    INTERNATIONAL JOURNAL OF CARDIOLOGY　168　(2)　1585-1586　2013/09

    DOI： 10.1016/j.ijcard.2013.01.045 　

    ISSN： 0167-5273

    eISSN： 1874-1754

  28. Response to comment on: Satoh-Asahara et al. Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia. Diabetes Care 2012;35:2631-2639 Peer-reviewed

    Noriko Satoh-Asahara, Akira Shimatsu, Hiromichi Wada, Takayoshi Suganami, Koji Hasegawa, Yoshihiro Ogawa

    DIABETES CARE　36　(7)　E110-E110　2013/07

    DOI： 10.2337/dc13-0376 　

    ISSN： 0149-5992

    eISSN： 1935-5548

  29. Role of homeobox genes in the hypothalamic development and energy balance Peer-reviewed

    Takao Kaji, Katsunori Nonogaki

    Frontiers in Bioscience　18　(2)　740-747　2013/01/01

    DOI： 10.2741/4136 　

    ISSN： 1093-9946

  30. Liraglutide suppresses the plasma levels of active and des-acyl ghrelin independently of active glucagon-like Peptide-1 levels in mice. Peer-reviewed

    Nonogaki K, Suzuki M

    ISRN endocrinology　2013　184753　2013

    DOI： 10.1155/2013/184753 　

    ISSN： 2090-4630

  31. Dysglycemia and Cardiovascular Risk Peer-reviewed

    Katsunori Nonogaki

    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　60　(12)　1121-1121　2012/09

    DOI： 10.1016/j.jacc.2012.03.078 　

    ISSN： 0735-1097

  32. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake Peer-reviewed

    Hongxia Ren, Ian J. Orozco, Ya Su, Shigetomo Suyama, Roger Gutierrez-Juarez, Tamas L. Horvath, Sharon L. Wardlaw, Leona Plum, Ottavio Arancio, Domenico Accili

    CELL　149　(6)　1314-1326　2012/06

    DOI： 10.1016/j.cell.2012.04.032 　

    ISSN： 0092-8674

    eISSN： 1097-4172

  33. Hepatic peroxisome proliferator-activated receptor-gamma-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals Peer-reviewed

    Kenji Uno, Tetsuya Yamada, Yasushi Ishigaki, Junta Imai, Yutaka Hasegawa, Junhong Gao, Keizo Kaneko, Kimihiko Matsusue, Tomomi Yamazaki, Yoshitomo Oka, Hideki Katagiri

    EUROPEAN HEART JOURNAL　33　(10)　1279-1289　2012/05

    DOI： 10.1093/eurheartj/ehr265 　

    ISSN： 0195-668X

  34. A Case of Slowly Progressive Type 1 Diabetes with Insulin Independence Maintained for 10 Years with alpha-glucosidase Inhibitor Monotherapy Peer-reviewed

    Yuichiro Munakata, Tetsuya Yamada, Kazuma Takahashi, Sohei Tsukita, Kei Takahashi, Shojiro Sawada, Junta Imai, Yasushi Ishigaki, Yoshitomo Oka, Hideki Katagiri

    INTERNAL MEDICINE　51　(24)　3391-3394　2012

    DOI： 10.2169/internalmedicine.51.8123 　

    ISSN： 0918-2918

  35. SEROTONIN CONFLICT IN SLEEP-FEEDING Peer-reviewed

    Katsunori Nonogaki

    VITAMINS AND HORMONES: SLEEP HORMONES, VOL 89　89　223-239　2012

    DOI： 10.1016/B978-0-12-394623-2.00012-3 　

    ISSN： 0083-6729

  36. Genetics of Sleep and Sleep Disorders Peer-reviewed

    Amita Sehgal, Emmanuel Mignot

    CELL　146　(2)　194-207　2011/07

    DOI： 10.1016/j.cell.2011.07.004 　

    ISSN： 0092-8674

  37. Short-term effect of pitavastatin on the reactive hyperemic index in post-menopausal women with high levels in serum LDL-cholesterol Peer-reviewed

    Katsunori Nonogaki, Marina Suzuki, Naomi Kanai, Makiko Sumii, Takao Kaji

    INTERNATIONAL JOURNAL OF CARDIOLOGY　150　(2)　227-228　2011/07

    DOI： 10.1016/j.ijcard.2011.05.019 　

    ISSN： 0167-5273

  38. The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice Peer-reviewed

    Katsunori Nonogaki, Marina Suzuki, Mann Sanuki, Mamoru Wakameda, Tomohiro Tamari

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　411　(2)　445-448　2011/07

    DOI： 10.1016/j.bbrc.2011.06.175 　

    ISSN： 0006-291X

  39. Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　13　(9)　1261-1267　2010/10

    DOI： 10.1017/S1461145710000672 　

    ISSN： 1461-1457

  40. The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions Peer-reviewed

    Ryu Tominaga, Suguru Yamaguchi, Chihiro Satake, Masahiro Usui, Yasuhiro Tanji, Keiichi Kondo, Hideki Katagiri, Yoshitomo Oka, Hisamitsu Ishihara

    CELL BIOCHEMISTRY AND FUNCTION　28　(5)　387-393　2010/07

    DOI： 10.1002/cbf.1667 　

    ISSN： 0263-6484

  41. Contribution of central SGK-1 to the acute phase responses of mice to social isolation Peer-reviewed

    Takao Kaji, Katsunori Nonogaki

    Frontiers in Bioscience - Elite　2　(4)　1355-1361　2010/01/06

    ISSN： 1945-0494 1945-0508

  42. Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice Peer-reviewed

    Katsunori Nonogaki, Takao Kaji, Yukie Ohba, Makiko Sumii, Mamoru Wakameda, Tomohiro Tamari

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　386　(2)　311-315　2009/08

    DOI： 10.1016/j.bbrc.2009.06.023 　

    ISSN： 0006-291X

  43. Fluvoxamine exerts anorexic effect in 5-HT(2C) receptor mutant mice with heterozygous mutation of beta-endorphin gene Peer-reviewed

    Katsunori Nonogaki, Yukie Ohba, Mamoru Wakameda, Tomohiro Tamari

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　12　(4)　547-552　2009/05

    DOI： 10.1017/S1461145708009619 　

    ISSN： 1461-1457

  44. Novel modulators for body weight changes induced by fasting and re-feeding in mice Peer-reviewed

    Katsunori Nonogaki, Yukie Ohba, Makiko Sumii, Mamoru Wakameda, Tomohiro Tamari

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　378　(2)　249-254　2009/01

    DOI： 10.1016/j.bbrc.2008.11.031 　

    ISSN： 0006-291X

  45. Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice Peer-reviewed

    Katsunori Nonogaki, Yukie Ohba, Makiko Sumii, Yoshitomo Oka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　372　(1)　186-190　2008/07

    DOI： 10.1016/j.bbrc.2008.05.010 　

    ISSN： 0006-291X

  46. Eating attitudes and body dissatisfaction in adolescents: Cross-cultural study Peer-reviewed

    Mami Kayano, Kazuhiro Yoshiuchi, Samir Al-Adawi, Nonna Viernes, Atsu S. S. Dorvlo, Hiroaki Kumano, Tomifusa Kuboki, Akira Akabayashi

    PSYCHIATRY AND CLINICAL NEUROSCIENCES　62　(1)　17-25　2008/02

    DOI： 10.1111/j.1440-1819.2007.01772.x 　

    ISSN： 1323-1316

  47. Ghrelin and feedback systems Peer-reviewed

    Katsunori Nonogaki

    VITAMINS AND HORMONES, GHRELIN　77　149-170　2008

    DOI： 10.1016/S0083-6729(06)77007-8 　

    ISSN： 0083-6729

  48. A real-time assessment of the effect of exercise in chronic fatigue syndrome Peer-reviewed

    Kazuhiro Yoshiuchi, Dane B. Cook, Kyoko Ohashi, Hiroaki Kumano, Tomifusa Kuboki, Yoshiharu Yamamoto, Beniamin H. Natelson

    PHYSIOLOGY & BEHAVIOR　92　(5)　963-968　2007/12

    DOI： 10.1016/j.physbeh.2007.07.001 　

    ISSN： 0031-9384

  49. Social isolation affects the development of obesity and type 2 diabetes in mice Peer-reviewed

    Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka

    ENDOCRINOLOGY　148　(10)　4658-4666　2007/10

    DOI： 10.1210/en.2007-0296 　

    ISSN： 0013-7227

  50. Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT(2C) receptor inactivation induce appetite-sup pressing effects in mice via 5-HT(1B) receptors Peer-reviewed

    Katsunori Nonogaki, Kana Nozue, Yukiko Takahashi, Nobuyuki Yamashita, Shuichi Hiraoka, Hiroaki Kumano, Tomifusa Kuboki, Yohsitomo Oka

    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY　10　(5)　675-681　2007/10

    DOI： 10.1017/S1461145706007206 　

    ISSN： 1461-1457

  51. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation Peer-reviewed

    Lora K. Heisler, Nina Pronchuk, Katsunori Nonogaki, Ligang Zhou, Jacob Raber, Loraine Tung, Giles S. H. Yeo, Stephen O'Rahilly, William F. Colmers, Joel K. Elmquist, Laurence H. Tecott

    JOURNAL OF NEUROSCIENCE　27　(26)　6956-6964　2007/06

    DOI： 10.1523/JNEUROSCI.2584-06.2007 　

    ISSN： 0270-6474

  52. Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice Peer-reviewed

    Katsunori Nonogaki, Kana Nozue, Tornifusa Kuboki, Yoshitomo Oka

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY　292　(5)　R1775-R1781　2007/05

    DOI： 10.1152/ajpregu.00527.2006 　

    ISSN： 0363-6119

  53. Isn't this just snacking? The potential adverse effects of night-eating symptoms on treatment adherence and outcomes in patients with diabetes: Response to Morse et al. [8] Peer-reviewed

    Katsunori Nonogaki, Kyoko Tateishi, Naohiko Nonogaki

    Diabetes Care　30　(5)　e38　2007/05

    DOI： 10.2337/dc06-2628 　

    ISSN： 0149-5992

  54. Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese A(y) mice Peer-reviewed

    Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　351　(4)　1078-1082　2006/12

    DOI： 10.1016/j.bbrc.2006.10.173 　

    ISSN： 0006-291X

  55. Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in A(y) mice Peer-reviewed

    Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka

    ENDOCRINOLOGY　147　(12)　5893-5900　2006/12

    DOI： 10.1210/en.2006-0418 　

    ISSN： 0013-7227

  56. Changes in heart rate with refeeding in anorexia nervosa: A pilot study Peer-reviewed

    Nahoko (Miyasaka) Yoshida, Kazuhiro Yoshiuchi, Hiroaki Kumano, Tadashi Sasaki, Tomifusa Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH　61　(4)　571-575　2006/10

    DOI： 10.1016/j.jpsychores.2006.02.009 　

    ISSN： 0022-3999

    eISSN： 1879-1360

  57. Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice Peer-reviewed

    K Nonogaki, K Ohashi-Nozue, Y Oka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　344　(2)　696-699　2006/06

    DOI： 10.1016/j.bbrc.2006.03-196 　

    ISSN： 0006-291X

  58. A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice Peer-reviewed

    K Nonogaki, K Ohashi-Nozue, Y Oka

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　341　(3)　703-707　2006/03

    DOI： 10.1016/j.bbrc.2006.01.021 　

    ISSN： 0006-291X

  59. Clinical worth of adiponectin levels in obesity and glycemic control of Japanese type 2 diabetic patients Peer-reviewed

    K Nonogaki, H Kumano, Y Ootsuka, A Takeuchi, N Nonogaki

    DIABETES CARE　26　(11)　3198-3198　2003/11

    ISSN： 0149-5992

  60. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2c receptor mutant mice Peer-reviewed

    K Nonogaki, L Abdallah, EH Goulding, SJ Bonasera, LH Tecott

    DIABETES　52　(2)　315-320　2003/02

    ISSN： 0012-1797

  61. Altered gene expressions involved in energy expenditure in 5-HT2C receptor mutant mice Peer-reviewed

    K Nonogaki, RA Memon, C Grunfeld, KR Feingold, LH Tecott

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　295　(2)　249-254　2002/07

    ISSN： 0006-291X

  62. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: Troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice Peer-reviewed

    RA Memon, LH Tecott, K Nonogaki, A Beigneux, AH Moser, C Grunfeld, KR Feingold

    ENDOCRINOLOGY　141　(11)　4021-4031　2000/11

    ISSN： 0013-7227

    eISSN： 1945-7170

  63. New insights into sympathetic regulation of glucose and fat metabolism Peer-reviewed

    K Nonogaki

    DIABETOLOGIA　43　(5)　533-549　2000/05

    ISSN： 0012-186X

    eISSN： 1432-0428

  64. Obesity: Autonomic circuits versus feeding Peer-reviewed

    K Nonogaki

    NATURE MEDICINE　5　(7)　742-743　1999/07

    ISSN： 1078-8956

  65. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene Peer-reviewed

    K Nonogaki, AM Strack, MF Dallman, LH Tecott

    NATURE MEDICINE　4　(10)　1152-1156　1998/10

    ISSN： 1078-8956

  66. Stress, acute hyperglycemia, and hyperlipidemia - Role of the autonomic nervous system and cytokines Peer-reviewed

    K Nonogaki, A Iguchi

    TRENDS IN ENDOCRINOLOGY AND METABOLISM　8　(5)　192-197　1997/07

    ISSN： 1043-2760

  67. Role of central neural mechanisms in the regulation of hepatic glucose metabolism Peer-reviewed

    K Nonogaki, A Iguchi

    LIFE SCIENCES　60　(11)　797-807　1997/02

    ISSN： 0024-3205

  68. LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats Peer-reviewed

    K Nonogaki, XM Pan, AH Moser, J Shigenaga, Staprans, I, N Sakamoto, C Grunfeld, KR Feingold

    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM　271　(3)　E521-E528　1996/09

    ISSN： 0193-1849

  69. beta-Nerve growth factor as a mediator of the acute phase response in vivo Peer-reviewed

    K Nonogaki, AH Moser, J Shigenaga, KR Feingold, C Grunfeld

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　219　(3)　956-961　1996/02

    ISSN： 0006-291X

  70. Increase in insulin release from rat pancreatic islets by quinolone antibiotics Peer-reviewed

    N Maeda, T Tamagawa, Niki, I, H Miura, K Ozawa, G Watanabe, K Nonogaki, K Uemura, A Iguchi

    BRITISH JOURNAL OF PHARMACOLOGY　117　(2)　372-376　1996/01

    ISSN： 0007-1188

  71. KERATINOCYTE GROWTH-FACTOR INCREASES FATTY-ACID MOBILIZATION AND HEPATIC TRIGLYCERIDE SECRETION IN RATS Peer-reviewed

    K NONOGAKI, XM PAN, AH MOSER, STAPRANS, I, KR FEINGOLD, C GRUNFELD

    ENDOCRINOLOGY　136　(10)　4278-4284　1995/10

    ISSN： 0013-7227

  72. LIPOTEICHOIC ACID STIMULATES LIPOLYSIS AND HEPATIC TRIGLYCERIDE SECRETION IN RATS IN-VIVO Peer-reviewed

    K NONOGAKI, AH MOSER, XM PAN, STAPRANS, I, C GRUNFELD, KR FEINGOLD

    JOURNAL OF LIPID RESEARCH　36　(9)　1987-1995　1995/09

    ISSN： 0022-2275

  73. NEUROPEPTIDE-Y INHIBITS IN-VIVO SPECIFIC ANTIBODY-PRODUCTION IN RATS Peer-reviewed

    EM FRIEDMAN, MR IRWIN, K NONOGAKI

    BRAIN BEHAVIOR AND IMMUNITY　9　(3)　182-189　1995/09

    ISSN： 0889-1591

  74. INTERLEUKIN-6 STIMULATES HEPATIC TRIGLYCERIDE SECRETION IN RATS Peer-reviewed

    K NONOGAKI, GM FULLER, NL FUENTES, AH MOSER, STAPRANS, I, C GRUNFELD, KR FEINGOLD

    ENDOCRINOLOGY　136　(5)　2143-2149　1995/05

    ISSN： 0013-7227

  75. ALPHA-ADRENERGIC RECEPTORS MEDIATE THE HYPERTRIGLYCERIDEMIA INDUCED BY ENDOTOXIN, BUT NOT TUMOR-NECROSIS-FACTOR, IN RATS Peer-reviewed

    K NONOGAKI, AH MOSER, KR FEINGOLD, C GRUNFELD

    ENDOCRINOLOGY　135　(6)　2644-2650　1994/12

    ISSN： 0013-7227

    eISSN： 1945-7170

  76. EFFECTS OF ADRENOCEPTOR ANTAGONISTS ON THE HYPERTHERMIA AND HYPERGLYCEMIA-INDUCED BY PROSTAGLANDIN-F2-ALPHA IN RATS Peer-reviewed

    K NONOGAKI, A IGUCHI, N SAKAMOTO

    EUROPEAN JOURNAL OF PHARMACOLOGY　262　(1-2)　177-180　1994/09

    ISSN： 0014-2999

  77. BICUCULLINE METHIODIDE INFLUENCES THE CENTRAL-NERVOUS-SYSTEM TO PRODUCE HYPERGLYCEMIA IN RATS Peer-reviewed

    K NONOGAKI, A IGUCHI, N SAKAMOTO

    JOURNAL OF NEUROENDOCRINOLOGY　6　(4)　443-446　1994/08

    ISSN： 0953-8194

  78. CNS REGULATION OF BLOOD LACTATE CONCENTRATION IN ANESTHETIZED RATS Peer-reviewed

    G WATANABE, T ISHIGURO, H MIURA, K UEMURA, Y HIYOSHI, K OZAWA, K NONOGAKI, T TAMAGAWA, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　54　(20)　1491-1499　1994

    ISSN： 0024-3205

  79. ACTIVATION OF CENTRAL GABA(A) RECEPTORS SUPPRESSES THE ALTERATION OF PLASMA-CATECHOLAMINE LEVELS INDUCED BY NEOSTIGMINE OR HISTAMINE IN RATS Peer-reviewed

    K NONOGAKI, K MIZUNO, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　55　(21)　PL409-PL413　1994

    ISSN： 0024-3205

    eISSN： 1879-0631

  80. EFFECTS OF CENTRAL GABA RECEPTORS ACTIVATION ON CATECHOLAMINE SECRETION IN RATS Peer-reviewed

    K NONOGAKI, K MIZUNO, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　55　(12)　PL239-PL243　1994

    ISSN： 0024-3205

    eISSN： 1879-0631

  81. Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in vivo. Peer-reviewed

    Nonogaki K, Moser AH, Pan XM, Staprans I, Grunfeld C, Feingold KR

    J Lipid Res.　136　(5)　2143-2149　1994

  82. ACTIVATION OF GABA-A RECEPTORS IN HYPOTHALAMUS MODULATES PGF2-ALPHA-INDUCED OR PGE2-INDUCED CATECHOLAMINE SECRETION IN RATS Peer-reviewed

    K NONOGAKI, S MIZUNO, T TAMAGAWA, G WATANABE, N SAKAMOTO, A IGUCHI

    PROSTAGLANDINS　45　(2)　111-119　1993/02

    ISSN： 0090-6980

  83. INVOLVEMENT OF CENTRAL CHOLINERGIC MUSCARINIC RECEPTORS AND HISTAMINE-H1 RECEPTORS IN HYPERGLYCEMIA INDUCED BY PROSTAGLANDIN-F2-ALPHA IN RATS Peer-reviewed

    K NONOGAKI, A IGUCHI, LX ZHU, Y KUNOH, T TAMAGAWA, N SAKAMOTO

    NEUROENDOCRINOLOGY　57　(1)　146-151　1993/01

    ISSN： 0028-3835

  84. HISTAMINE-INDUCED, CENTRAL NERVOUS SYSTEM-MEDIATED HYPERGLYCEMIA IS SUPPRESSED BY ATROPINE IN THE BRAIN Peer-reviewed

    K NONOGAKI, XZ LI, T TAMAGAWA, G WATANABE, Y HIYOSHI, K OZAWA, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　52　(15)　PL107-PL110　1993

    ISSN： 0024-3205

    eISSN： 1879-0631

  85. INTRAHYPOTHALAMIC, BUT NOT HIPPOCAMPAL, ADMINISTRATION OF MUSCIMOL SUPPRESSES HYPERGLYCEMIA-INDUCED BY HIPPOCAMPAL NEOSTIGMINE IN ANESTHETIZED RATS Peer-reviewed

    K OZAWA, H MIURA, T TAMAGAWA, Y HIYOSHI, K NONOGAKI, N MAEDA, G WATANABE, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　53　(25)　1903-1909　1993

    ISSN： 0024-3205

  86. ACTIVATION OF GABA-A RECEPTOR IN THE BRAIN SUPPRESSES NEOSTIGMINE OR HISTAMINE-INDUCED CENTRAL NERVOUS SYSTEM-MEDIATED HYPERGLYCEMIA Peer-reviewed

    K NONOGAKI, XZ LI, K OZAWA, H MIURA, G WATANABE, Y HIYOSHI, T TAMAGAWA, N SAKAMOTO, A IGUCHI

    LIFE SCIENCES　53　(9)　PL159-PL163　1993

    ISSN： 0024-3205

  87. EFFECTS OF THE PROTEIN PHOSPHATASE INHIBITORS OKADAIC ACID AND CALYCULIN-A ON INSULIN RELEASE FROM RAT PANCREATIC-ISLETS Peer-reviewed

    T TAMAGAWA, A IGUCHI, K UEMURA, H MIURA, K NONOGAKI, T ISHIGURO, N SAKAMOTO

    ENDOCRINOLOGIA JAPONICA　39　(3)　325-329　1992/06

    ISSN： 0013-7219

  88. EFFECTS OF ADRENERGIC BLOCKERS ON CENTRAL NERVOUS SYSTEM-MEDIATED HYPERGLYCEMIA IN FED RATS Peer-reviewed

    Y KUNOH, A IGUCHI, K UEMURA, H MIURA, T TAMAGAWA, T MANO, K NONOGAKI, M GOTOH, N SAKAMOTO

    METABOLISM-CLINICAL AND EXPERIMENTAL　41　(5)　471-475　1992/05

    ISSN： 0026-0495

  89. ROLE OF BRAIN HISTAMINE H1-RECEPTORS AND H2-RECEPTORS IN NEOSTIGMINE-INDUCED HYPERGLYCEMIA IN RATS Peer-reviewed

    K NONOGAKI, A IGUCHI, XZ LI, T TAMAGAWA, G WATANABE, Y HIYOSHI, N SAKAMOTO

    LIFE SCIENCES　51　(12)　PL131-PL134　1992

    ISSN： 0024-3205

    eISSN： 1879-0631

  90. MECHANISM OF INTRAHIPPOCAMPAL NEOSTIGMINE-INDUCED HYPERGLYCEMIA IN FED RATS Peer-reviewed

    A IGUCHI, K UEMURA, H MIURA, T ISHIGURO, K NONOGAKI, T TAMAGAWA, K GOSHIMA, N SAKAMOTO

    NEUROENDOCRINOLOGY　55　(1)　44-50　1992/01

    ISSN： 0028-3835

  91. HYPERGLYCEMIA INDUCED BY HIPPOCAMPAL ADMINISTRATION OF NEOSTIGMINE IS SUPPRESSED BY INTRAHYPOTHALAMIC ATROPINE Peer-reviewed

    A IGUCHI, K UEMURA, Y KUNOH, H MIURA, T ISHIGURO, K NONOGAKI, T TAMAGAWA, M GOTOH, N SAKAMOTO

    NEUROPHARMACOLOGY　30　(10)　1129-1131　1991/10

    ISSN： 0028-3908

  92. RELATIVE CONTRIBUTION OF NERVOUS-SYSTEM AND HORMONES TO HYPERGLYCEMIA INDUCED BY THYROTROPIN-RELEASING-HORMONE IN FED RATS Peer-reviewed

    T ISHIGURO, A IGUCHI, Y KUNOH, M GOTO, K UEMURA, H MIURA, K NONOGAKI, N SAKAMOTO

    NEUROENDOCRINOLOGY　54　(1)　1-6　1991/07

    ISSN： 0028-3835

  93. DISSOCIATION OF HYPERTHERMIC AND HYPERGLYCEMIC EFFECTS OF CENTRAL PROSTAGLANDIN-F2-ALPHA Peer-reviewed

    K NONOGAKI, A IGUCHI, A YATOMI, K UEMURA, H MIURA, T TAMAGAWA, T ISHIGURO, N SAKAMOTO

    PROSTAGLANDINS　41　(5)　451-462　1991/05

    ISSN： 0090-6980

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Misc. 8

  1. Comment on: Satoh-Asahara et al. Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia. Diabetes Care 2012;35:2631-2639

    Katsunori Nonogaki

    DIABETES CARE　36　(7)　E109-E109　2013/07

    DOI： 10.2337/dc13-0156 　

    ISSN： 0149-5992

  2. Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

    Nonogaki K, Nozue K, Takahashi Y, Yamashita N, Hiraoka S, Kumano H, Kuboki T, Oka Y

    Int J Neuropsychopharmacol　1-7　2006

  3. Role of 5-HT2C receptors in regulation of energy metabolism and the anorexic effects of SSRI and SNRI

    K Nonogaki

    JOURNAL OF PSYCHOSOMATIC RESEARCH　58　(6)　S22-S22　2005/06

    ISSN： 0022-3999

  4. Isolation stress can modulate energy homeostasis associated with alterations of plasma insulin and ghrelin levels in mice

    Y Takahashi, K Nonogaki, H Kumano, T Kuboki

    JOURNAL OF PSYCHOSOMATIC RESEARCH　58　(6)　S22-S22　2005/06

    ISSN： 0022-3999

  5. Dissociation of 5-HT2C receptor signaling and central melanocortin pathways in regulation of appetite

    K Nonogaki, Y Mooka

    DIABETES　54　A384-A384　2005

    ISSN： 0012-1797

  6. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2c receptor mutant mice

    K Nonogaki, KR Feingold, LH Tecott

    DIABETES　51　A419-A419　2002/06

    ISSN： 0012-1797

  7. Serotonin 5-HT2c receptor mutant mice develop obesity, a prediabetic state and moderate leptin insensitivity

    K Nonogaki, AM Strack, MF Dallman, LH Tecott

    DIABETES　47　A320-A320　1998/05

    ISSN： 0012-1797

  8. Effects of adrenergic blockers on 2-deoxy-D-glucose induced hyperglycemia in fed rats. Peer-reviewed

    A. Iguchi, H. Matsunaga, M. Gotoh, H. Miura, K. Uemura, T. Tamagawa, K. Nonogaki, N. Sakamoto

    Exp. Clin. Endocrinol.　9　7-12　1990

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Industrial Property Rights 16

  1. 体内FGF15/19増加用組成物

    野々垣勝則

    特許7408517

    Property Type: Patent

  2. 超音波照射装置及び診断システム

    野々垣 勝則

    特許6373647

    Property Type: Patent

  3. 超音波照射装置及び診断システム

    野々垣 勝則

    Property Type: Patent

  4. マウスの生育過程において社会的隔離に対する肥満又は糖尿病発症の感受性を解析する方法

    野々垣 勝則

    Property Type: Patent

  5. 超音波照射装置

    野々垣 勝則

    Property Type: Patent

  6. 超音波照射装置

    野々垣 勝則

    Property Type: Patent

  7. 超音波発生装置

    野々垣 勝則, 岡山 克彦

    Property Type: Patent

  8. レプチンシグナル伝達障害モデル動物

    野々垣 勝則

    Property Type: Patent

  9. 体重減少薬

    野々垣 勝則

    Property Type: Patent

  10. 被検物質の食欲抑制効果をスクリーニングする方法

    野々垣 勝則

    Property Type: Patent

  11. 超音波照射パッド、固定パッド、及び、超音波照射装置

    野々垣 勝則

    特許第6004231号

    Property Type: Patent

  12. 超音波治療システム

    野々垣勝則

    特許6775222

    Property Type: Patent

    Holder: 東北大学、（株）コスモスウエブ

  13. 超音波治療システム（特許第6775222号

    野々垣勝則

    特許第6775222号

    Property Type: Patent

  14. A Method of irradiating supersonic waves

    野々垣勝則

    特許US9649511

    Property Type: Patent

  15. 薬品決定支援システム、および薬品決定支援プログラム

    野々垣勝則

    特許第4176438号

    Property Type: Patent

  16. 生体の代謝状態を解析する装置及び記録媒介

    野々垣勝則

    特許第3848818号

    Property Type: Patent

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Research Projects 4

  1. 食事性タンパク質による摂食シグナルと代謝制御機構

    野々垣 勝則

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 東北大学

    2022/04/01 - 2025/03/31

  2. Determining GLP-1 responsive genes involved in the regulation of appetite and energy metabolism

    NONOGAKI Katsunori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Tohoku University

    2013/04/01 - 2015/03/31

    More details Close

    Here we show that systemic administration of liraglutide, a long-acting human glucagon-like peptide-1 (GLP-1) analog, significantly decreased food intake, body weight, and blood glucose levels at 24 h after its administration in individually housed KKAy mice. In addition, the systemic administration of liraglutide significantly increased plasma fibroblast growth factor (Fgf) 21 levels associated with increases in the expression of hepatic Fgf21, while having no effects on the expression of Fgf21 in white adipose tissue. Despite remarkably increased plasma active GLP-1 levels, the ingestion of alogliptin, a selective dipeptidyl peptidase-4 inhibitor, had no effects on food intake, body weight, blood glucose levels, and plasma Fgf21 levels. These findings suggest that systemic administration of liraglutide induces hepatic Fgf21 production and suppresses the social isolation-induced obesity and diabetes independently of insulin, glucagon, and active GLP-1 in KKAy mice.

  3. Age-associated changes in metabolic responses and the regulatory system.

    NONOGAKI Katunori

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2008 - 2009

    More details Close

    Social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. Under the same housing condition, genetic deletion of beta-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of beta-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of beta-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice. Despite no changes in plasma des-acyl ghrelin and the expression of hypothalamic neuropeptide Y and proopiomelanocortin, plasma active ghrelin levels and the expression of hypothalamic SGK-1 were increased in the acute-isolated C57BL6J mice. Injection of SGK-1 small interfering RNA oligonucleotide into the third cerebral ventricle suppressed the acute social isolation-induced decreases in body weight and increases in plasma active ghrelin levels. Pretreatment with phentolamine significantly suppressed the decreases in body weight. These finding suggest that hypothalamic SGK-1 contributes to the isolation stress-induced body weight reductions and increases in plasma active ghrelin levels via, at least partly, altered central autonomic outflow in mice.

  4. Role of brain serotonin systems and ghrelin in the regulation of feeding behavior

    NONOGAKI Katsunori, EZAKI Osamu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Tohoku University

    2004 - 2005

    More details Close

    Brain serotonin (5-hydroxytryptamine ; 5-HT) systems contribute to regulate eating behavior and energy homeostasis. 5-HT2C receptors and 5-HT1B receptors have been shown to mediate anorexic effects of 5-HT drugs such as d-fenfluramine, which stimulates 5-HT release and inhibits 5-HT reuptake, and m-chlorophenylpiperazine (mCPP), a 5-HT2C receptor agonist. Here we report that 24-h fasting increased the expression of hypothalamic 5-HT2C receptor and 5-HT1B receptor genes in association with increases in plasma active ghrelin levels compared with fed state in mice. Treatment with mCPP or fenfluramine significantly inhibited the increases in plasma active ghrelin levels. mCPP or fenfluramine significantly increased the expression of hypothalamic pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript genes while having no significant effects on the expression of hypothalamic neuropeptide Y, agouti- related protein and ghrelin genes. These results suggest that there is a negative feedback system between brain 5-HT systems and plasma active ghrelin levels in energy homeostasis in mice (BBRC 341:703,2006). Serum- and glucocorticoid-induced protein kinase (SGK) is a serine/threonine-specific protein kinase that is transcriptionally regulated by serum, glucorticoids, and mineral corticoids. Here, we report that fasting or obesity with hyperphagia increased hypothalamic SGK-1 gene expression. Hypothalamic SGK-1 mRNA levels were proportional to daily food intake and body weights in C57BL6J mice, KK mice, and KKA^y mice matched for age. Plasma des-acyl ghrelin, but not active ghrelin, levels were inversely proportional to daily food intake and body weights among these animals. Under conditions of increased energy usage such as fasting, hypothalamic SGK-1 gene expression and plasma des-acyl ghrelin levels were positively correlated while during conditions of increased energy storage, they were negatively correlated. These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice (BBRC 344:696,2006).

Media Coverage 7

  1. Research News: Tryptophan Hydroxylase 1 Regulates Tryptophan and its Metabolites

    TOHOKU UNIVERSITY CREATING GLOBAL EXCELLENCE　https://www.tohoku.ac.jp/en/press/tryptophan_hydroxylase_1_regulates_tryptophan_and_its_metabolites.html

    2025/05/15

    Type: Internet

  2. セロトニン産生酵素Tph1は必須アミノ酸のトリプトファンと血糖値を制御する ─糖尿病や肥満を予防・治療する健康食品開発や創薬に期待─

    東北大学 2025年 | プレスリリース・研究成果　https://www.tohoku.ac.jp/japanese/2025/05/press20250509-03-tryptophan.html

    2025/05/09

    Type: Internet

  3. https://www.youtube.com/watch?v=jd9hRcnLs3A

    https://www.youtube.com/watch?v=jd9hRcnLs3A　https://www.youtube.com/watch?v=jd9hRcnLs3A

    2024/12

    Type: Internet

  4. 野々垣勝則教授が「令和５年度 東北地方発明表彰」の発明奨励賞を受賞しました

    東北大学未来科学技術共同研究センター、東北大学サイクロトロン・RIセンター　https://www.niche.tohoku.ac.jp/?p=7514

    2023/10/23

    Type: Internet

  5. Ingestion of whey protein and bconglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice

    2023/06/05

    Type: Internet

  6. 食事性蛋白質による胆汁酸シグナルの変化を発見 -腸細胞のFGF15/19産生に着目した食事のイノベーションへ-

    東北大学未来科学技術共同研究センタープレスリリース

    2023/02/13

    Type: Internet

  7. 乳清タンパク質ホエイプロテインの新たな効能を発見 - セロトニンとFGF21の分泌抑制により、2型糖尿病の発症を抑制 -

    東北大学プレスリリース・研究成果　日本経済新聞等複数、インターネットメデイア

    2020/10/07

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Academic Activities 16

  1. Guest Editor, Special Issue: New Insights into Tryptophan Metabolism, International Journal of Molecular Sciences

    2025/06/26 - Present

  2. Brain Research Bulltein, Editorial Board

    2025/06/16 - Present

    Activity type: Peer review

  3. BBA-Molecular Basis of Disease

    2024/06 - Present

    Activity type: Peer review

  4. nt. J. Mol. Sci. Mol Endcrinology and Metabolism section, Special Issue Unveiling Metabolic Regulation Networks and Mechanisms. https://www.mdpi.com/journal/ijms/special_issues/3F2M3JW788

    2024/06/01 - Present

  5. Diabetes Res. Clin. Practce

    2024/04 - Present

    Activity type: Scientific advice/Review

  6. Diabetes

    2024/01 - Present

    Activity type: Peer review

  7. Associate Editor

    2023/06 - Present

    Activity type: Scientific advice/Review

  8. Topic Editor, Insights in Obesity 2023

    2023/05 - Present

    Activity type: Peer review

  9. Topical Advisory Panel for “Molecular Endocrinology and Metabolism”

    2023/04 - Present

    Activity type: Scientific advice/Review

  10. Guest Editor, Special Issue "New sights into the Serotonin system, Obesity and Diabetes", International Journal of Molecular Sciences.

    2023/04 - Present

    Activity type: Peer review

  11. Endocrinology

    2023 - Present

    Activity type: Peer review

  12. Associate Editor, Obesity

    2022/10 - Present

    Activity type: Peer review

  13. Obesity section, Frontiers in Endocrinology

    2022/08 - Present

    Activity type: Peer review

  14. Guest Editor, Special Issue "State-of-the-Art Molecular Neurobiology in Japan"

    2022 - Present

    Activity type: Peer review

  15. The European Journal Pharmacology-Editorial Manager

    2025/01/07 -

    Activity type: Scientific advice/Review

  16. Serotonin Network and Energy Metabolism as a Special Issue in IJMS

    Activity type: Peer review

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