Details of the Researcher

PHOTO

Masanobu Kamitakahara
Section
Graduate School of Environmental Studies
Job title
Professor
Degree

  • 博士（工学）（京都大学）

  • 修士（工学）（京都大学）

Committee Memberships 2

  • ニューセラミックス懇話会　ニュースレター委員

    2006/04 - 2007/03

  • ニューセラミックス懇話会　ニュースレター委員

    2006/04 - 2007/03

Professional Memberships 7

  • 日本歯科理工学会

  • 日本無機リン化学会

  • ニューセラミックス懇話会

  • 整形外科セラミック・インプラント研究会

  • 高分子学会

  • 日本バイオマテリアル学会

  • 日本セラミックス協会

︎Show all ︎Show first 5

Research Interests 4

  • ハイブリッド

  • 水酸アパタイト

  • 骨修復材料

  • 生体材料

Research Areas 3

  • Nanotechnology/Materials / Inorganic materials /

  • Life sciences / Biomaterials /

  • Life sciences / Biomedical engineering /

Awards 4

  1. 第64回（平成21年度）日本セラミックス協会賞 進歩賞

    2010/06/04　日本セラミックス協会　リン酸カルシウムの特性を活用した高機能人工骨の創製

  2. Award for Encouragement of Research in Materials Science

    2008/12/13　The IUMRS International Conference in Asia 2008　Preparation of Hydroxyapatite/Anatase Composite Granules by Hydrothermal Process

  3. 環境科学研究科研究奨励賞

    2008/09/05　東北大学大学院環境科学研究科

  4. World Young Fellow Meeting 2005 Presentation Award

    2005/01/20　43rd Symposium on Basic Science of Ceramics

Papers 214

  1. Design of bioresorbable calcium phosphate cement with high porosity via the addition of bioresorbable polymers Peer-reviewed

    Masanobu Kamitakahara, Kakeru Kato, Masaki Umetsu, Kumiko Yoshihara, Yasuhiro Yoshida

    Journal of Biomaterials Applications　39　557-565　2025/01

    Publisher: SAGE Publications

    DOI： 10.1177/08853282241277477 　

    ISSN： 0885-3282

    eISSN： 1530-8022

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    Novel calcium phosphate cements (CPCs) that can be resorbed into the human body need to be developed. One approach for improving bioresorbability is reducing the content of calcium phosphate in CPCs; however, this may induces difficulties in setting the cement and increases the risk of decay. Adding bioresorbable polymers to a liquid solution can shorten the setting time and inhibit decay during setting. A novel bioresorbable polymer, phosphorylated pullulan (PPL), was recently reported. The effect of adding PPL to α-tricalcium phosphate (α-TCP)-based CPCs was examined and compared to that of adding bioresorbable polymers such as collagen, chitosan, and alginate. Collagen did not significantly inhibit the conversion of α-TCP to hydroxyapatite (HA), and its combination with calcium phosphate decreased the setting time and suppressed decay; chitosan decreased the setting time when combined with calcium phosphate; and alginate inhibited the conversion of α-TCP to HA and contributed to suppressing the decay. In contrast, PPL slightly inhibited the conversion of α-TCP to HA; however, its combination with calcium phosphate decreased the setting time. Thus, selecting bioresorbable polymers can help effectively control the properties of CPCs.

  2. Effective selenate removal using pH modulated synthesis of biogenic jarosite: Comparative insight with non-biogenic jarosite and biogenic schwertmannite Peer-reviewed

    Upasana Jhariya, Mei-Fang Chien, Masaki Umetsu, Masanobu Kamitakahara

    Journal of Hazardous Materials　480　136256-136256　2024/12

    Publisher: Elsevier BV

    DOI： 10.1016/j.jhazmat.2024.136256 　

    ISSN： 0304-3894

  3. MC/FEM Combined Simulation of Co-firing Double Layers Compacts and Constrained Compacts Peer-reviewed

    Shuji MATSUMOTO, Hideaki MATSUBARA, Souta TERASAKA, Hidehiko AOKI, Masayoshi SHIMIZU, Hiroshi NOMURA, Masanobu KAMITAKAHARA

    Journal of the Japan Society of Powder and Powder Metallurgy　71　(9)　439-446　2024/09/15

    Publisher: Japan Society of Powder and Powder Metallurgy

    DOI： 10.2497/jjspm.24-00020 　

    ISSN： 0532-8799

    eISSN： 1880-9014

  4. Design of porous calcium phosphate cement composed of spherical porous granules based on precipitation of octacalcium phosphate

    Masanobu Kamitakahara, Hiromu Kato, Masaki Umetsu

    Journal of the Ceramic Society of Japan　132　(9)　560-562　2024/09/01

    Publisher: Ceramic Society of Japan

    DOI： 10.2109/jcersj2.24063 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  5. Preparation and Evaluation of Cements Using Spherical Porous β-Tricalcium Phosphate Granules

    Yuichiro Ito, Hiromu Kato, Masaki Umetsu, Masanobu Kamitakahara

    MATERIALS TRANSACTIONS　65　(2)　212-217　2024/02/01

    Publisher: Japan Institute of Metals

    DOI： 10.2320/matertrans.mt-y2023006 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  6. Preparation and Evaluation of Cement using Spherical Porous β-Tricalcium Phosphate Granules Peer-reviewed

    Yuichiro ITO, Hiromu KATO, Masaki UMETSU, Masanobu KAMITAKAHARA

    Journal of the Japan Society of Powder and Powder Metallurgy　70　(5)　242-247　2023/05

    DOI： 10.2497/jjspm.70.242 　

  7. Calcium phosphate cements comprising spherical porous calcium phosphate granules: synthesis, structure, and properties Peer-reviewed

    Masanobu Kamitakahara, Kanau Asahara, Hideaki Matsubara

    Journal of Asian Ceramic Societies　10　(4)　731-738　2022/10/02

    Publisher: Informa UK Limited

    DOI： 10.1080/21870764.2022.2123514 　

    eISSN： 2187-0764

  8. Experiment and DEM Simulation on Bending Fracture of Ultra-fine Grained Cemented Carbide

    Hiromu KATO, Hideaki MATSUBARA, Sota TERASAKA, Masayuki TAKADA, Masanobu KAMITAKAHARA

    Journal of the Japan Society of Powder and Powder Metallurgy　69　(6)　249-256　2022/06/15

    Publisher: Japan Society of Powder and Powder Metallurgy

    DOI： 10.2497/jjspm.69.249 　

    ISSN： 0532-8799

    eISSN： 1880-9014

  9. Sustainable process for enhanced CO2 mineralization of calcium silicates using a recyclable chelating agent under alkaline conditions Peer-reviewed

    Jiajie Wang, Noriaki Watanabe, Kosuke Inomoto, Masanobu Kamitakahara, Kengo Nakamura, Takeshi Komai, Noriyoshi Tsuchiya

    Journal of Environmental Chemical Engineering　10　(1)　107055-107055　2022/02

    Publisher: Elsevier BV

    DOI： 10.1016/j.jece.2021.107055 　

    ISSN： 2213-3437

  10. Preparing dense Yb<sub>2</sub>SiO<sub>5</sub> sintered bodies from Yb–Si–O powder synthesized by the polymerizable complex method and appropriate calcination

    Taishi YOKOI, Hideaki MATSUBARA, Takuto KAMITANI, Sota TERASAKA, Masanobu KAMITAKAHARA

    Journal of the Ceramic Society of Japan　130　(1)　118-122　2022/01/01

    Publisher: Ceramic Society of Japan

    DOI： 10.2109/jcersj2.21083 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  11. Enhancement of aragonite mineralization with a chelating agent for CO2 storage and utilization at low to moderate temperatures

    Jiajie Wang, Noriaki Watanabe, Kosuke Inomoto, Masanobu Kamitakahara, Kengo Nakamura, Takeshi Komai, Noriyoshi Tsuchiya

    Scientific Reports　11　(1)　2021/12

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s41598-021-93550-9 　

    eISSN： 2045-2322

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    <title>Abstract</title>Among the CaCO3 polymorphs, aragonite demonstrates a better performance as a filler material in the paper and plastic industries. Despite being ideal from the environmental protection perspective, the production of aragonite particles via CO2 mineralization of rocks is hindered by the difficulty in achieving high production efficiencies and purities, which, however, can be mitigated by exploiting the potential ability of chelating agents on metal ions extraction and carbonation controlling. Herein, chelating agent <italic>N,N</italic>-dicarboxymethyl glutamic acid (GLDA) was used to enhance the extraction of Ca from calcium silicate and facilitate the production of aragonite particles during the subsequent Ca carbonation. CO2 mineralization was promoted in the presence of 0.01–0.1 M GLDA at ≤ 80 °C, with the maximal CaCO3 production efficiency reached 308 g/kg of calcium silicate in 60 min using 0.03 M GLDA, which is 15.5 times higher than that without GLDA. In addition, GLDA showed excellent effects on promoting aragonite precipitation, e.g., the content of aragonite was only 5.1% in the absence of GLDA at 50 °C, whereas highly pure (&gt; 90%, increased by a factor of 18) and morphologically uniform aragonite was obtained using ≥ 0.05 M GLDA under identical conditions. Aragonite particle morphologies could also be controlled by varying the GLDA concentration and carbonation temperature. This study proposed a carbon-negative aragonite production method, demonstrated the possibility of enhanced and controlled aragonite particle production during the CO2 mineralization of calcium silicates in the presence of chelating agents.

  12. Monte Carlo Simulation and Experimental Study for Sintering and Grain Growth of Alumina Peer-reviewed

    Sota TERASAKA, Hideaki MATSUBARA, Hidehiko AOKI, Hiroshi NOMURA, Teiichi KIMURA, Masanobu KAMITAKAHARA

    Journal of the Japan Society of Powder and Powder Metallurgy　68　(7)　271-277　2021/07/15

    Publisher: Japan Society of Powder and Powder Metallurgy

    DOI： 10.2497/jjspm.68.271 　

    ISSN： 0532-8799

    eISSN： 1880-9014

  13. Incorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials Peer-reviewed

    Taishi Yokoi, Tomoyo Goto, Mitsuo Hara, Tohru Sekino, Takahiro Seki, Masanobu Kamitakahara, Chikara Ohtsuki, Satoshi Kitaoka, Seiji Takahashi, Masakazu Kawashita

    Communications Chemistry　4　(1)　2021/01

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1038/s42004-020-00443-5 　

    eISSN： 2399-3669

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    <title>Abstract</title>Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4 ∙ 5H2O) is a precursor of hydroxyapatite found in human bones and teeth, and is among the inorganic substances critical for hard tissue formation and regeneration in the human body. OCP has a layered structure and can incorporate carboxylate ions into its interlayers. However, studies involving the incorporation of tetracarboxylic and multivalent (pentavalent and above) carboxylic acids into OCP have not yet been reported. In this study, we investigate the incorporation of pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid), a type of tetracarboxylic acid, into OCP. We established that pyromellitate ions could be incorporated into OCP by a wet chemical method using an acetate buffer solution containing pyromellitic acid. The derived OCP showed a brilliant blue emission under UV light owing to the incorporated pyromellitate ions. Incorporation of a carboxylic acid into OCP imparted new functions, which could enable the development of novel functional materials for biomedical applications.

  14. Fabrication and evaluation of ascorbic acid phosphate-loaded spherical porous hydroxyapatite/octacalcium phosphate granules Peer-reviewed

    Masanobu KAMITAKAHARA, Airi ISHII, Hideaki MATSUBARA, Masakazu KAWASHITA, Maiko FURUYA, Hiroyasu KANETAKA

    Journal of the Ceramic Society of Japan　129　(1)　60-65　2021/01/01

    Publisher: Ceramic Society of Japan

    DOI： 10.2109/jcersj2.20170 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  15. Experimental and computational study on sintering of ceramic coating layers with complex porous structures Peer-reviewed

    Sota Terasaka, Hideaki Matsubara, Takashi Shirato, Masanobu Kamitakahara, Taishi Yokoi, Norio Yamaguchi, Byung‐Nam Kim

    Journal of the American Ceramic Society　103　(3)　2035-2047　2020/03

    Publisher: Wiley

    DOI： 10.1111/jace.16822 　

    ISSN： 0002-7820

    eISSN： 1551-2916

  16. Adhesion behavior of microorganisms isolated from soil on hydroxyapatite and other materials Peer-reviewed

    Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    Appl. Biochem. Biotechnol.　187　984-993　2019/03

  17. Preparation of spherical porous hydroxyapatite granules as support materials for microorganisms Peer-reviewed

    Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    J. Ceram. Soc. Japan　126　732-735　2018/09

    DOI： 10.2109/jcersj2.18089 　

  18. Formation Process of Hydroxyapatite Granules in Agarose Hydrogel by Electrophoresis Peer-reviewed

    Kenshiro Kimura, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku

    Crystal Growth and Design　18　(4)　1961-1966　2018/04/04

    Publisher: American Chemical Society

    DOI： 10.1021/acs.cgd.7b01154 　

    ISSN： 1528-7505 1528-7483

  19. Effect of silicate incorporation in alpha-tricalcium phosphate on behaviors of osteoblast-like cells Peer-reviewed

    Masanobu Kamitakahara, Takashi Shirato, Taishi Yokoi, Hideaki Matsubara, Yasuaki Shibata, Tohru Ikeda

    Key Engineering Materials　720　90-94　2017

    Publisher: Trans Tech Publications Ltd

    DOI： 10.4028/www.scientific.net/KEM.720.90 　

    ISSN： 1013-9826

  20. Effects of carbonate inclusion on fluoride ion removal by hydroxyapatite: A discussion from the viewpoint of hydroxyapatite dissolution Peer-reviewed

    Sota Terasaka, Masanobu Kamitakahara, Taishi Yokoi, Hideaki Matsubara

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　124　(12)　1211-1216　2016/12

    DOI： 10.2109/jcersj2.16186 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  21. Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model Peer-reviewed

    Kota Morishita, Eri Tatsukawa, Yasuaki Shibata, Fumio Suehiro, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku, Masahiro Umeda, Masahiro Nishimura, Tohru Ikeda

    ACTA BIOMATERIALIA　39　180-191　2016/07

    DOI： 10.1016/j.actbio.2016.05.002 　

    ISSN： 1742-7061

    eISSN： 1878-7568

  22. Spherical porous hydroxyapatite granules containing composites of magnetic and hydroxyapatite nanoparticles for the hyperthermia treatment of bone tumor Peer-reviewed

    Masanobu Kamitakahara, Naohiro Ohtoshi, Masakazu Kawashita, Koji Ioku

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　27　(5)　2016/05

    DOI： 10.1007/s10856-016-5704-7 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  23. Adhesion behaviors of Escherichia coli on hydroxyapatite Peer-reviewed

    Masanobu Kamitakahara, Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　61　169-179　2016/04

    DOI： 10.1016/j.msec.2015.12.026 　

    ISSN： 0928-4931

    eISSN： 1873-0191

  24. Effect of silicate incorporation on in vivo responses of α-tricalcium phosphate ceramics Peer-reviewed

    Masanobu Kamitakahara, Eri Tatsukawa, Yasuaki Shibata, Shota Umemoto, Taishi Yokoi, Koji Ioku, Tohru Ikeda

    Journal of Materials Science: Materials in Medicine　27　(5)　2016/03/22

    DOI： 10.1007/s10856-016-5706-5 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  25. Synthesis of layered double hydroxide coatings with an oriented structure and controllable thickness on aluminium substrates Peer-reviewed

    Taishi Yokoi, Mitsuo Hara, Takahiro Seki, Sota Terasaka, Masanobu Kamitakahara, Hideaki Matsubara

    CRYSTENGCOMM　18　(7)　1207-1214　2016

    DOI： 10.1039/c5ce02292d 　

    ISSN： 1466-8033

  26. Regulation and Biological Significance of Formation of Osteoclasts and Foreign Body Giant Cells in an Extraskeletal Implantation Model Peer-reviewed

    Gazi Jased Ahmed, Eri Tatsukawa, Kota Morishita, Yasuaki Shibata, Fumio Suehiro, Masanobu Kamitakahara, Taishi Yokoi, Takehiko Koji, Masahiro Umeda, Tohru Ikeda

    ACTA HISTOCHEMICA ET CYTOCHEMICA　49　(3)　97-107　2016

    DOI： 10.1267/ahc.16007 　

    ISSN： 0044-5991

    eISSN： 1347-5800

  27. Carbonate-containing hydroxyapatite synthesized by the hydrothermal treatment of different calcium carbonates in a phosphate-containing solution Peer-reviewed

    Masanobu Kamitakahara, Takuya Nagamori, Taishi Yokoi, Koji Ioku

    Journal of Asian Ceramic Societies　3　(3)　287-291　2015/09/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.jascer.2015.05.002 　

    ISSN： 2187-0764

  28. Morphological control of layered double hydroxide through a biomimetic approach using carboxylic and sulfonic acids Peer-reviewed

    Taishi Yokoi, Kei Tsukada, Sota Terasaka, Masanobu Kamitakahara, Hideaki Matsubara

    Journal of Asian Ceramic Societies　3　(3)　230-233　2015/09/01

    Publisher: Elsevier B.V.

    DOI： 10.1016/j.jascer.2015.05.004 　

    ISSN： 2187-0764

  29. Ability of Hydroxyapatite Synthesized from Waste Oyster Shells to Remove Fluoride Ions Peer-reviewed

    Sota Terasaka, Masanobu Kamitakahara, Taishi Yokoi, Hideaki Matsubara

    MATERIALS TRANSACTIONS　56　(9)　1509-1512　2015/09

    DOI： 10.2320/matertrans.M2015149 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  30. Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain Peer-reviewed

    Taishi Yokoi, Masanobu Kamitakahara, Chikara Ohtsuki

    DALTON TRANSACTIONS　44　(17)　7943-7950　2015

    DOI： 10.1039/c4dt03943b 　

    ISSN： 1477-9226

    eISSN： 1477-9234

  31. Effect of preparation temperature on the ability of bone char to remove fluoride ion and organic contaminants Peer-reviewed

    Sota Terasaka, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　122　(1432)　995-999　2014/12

    DOI： 10.2109/jcersj2.122.995 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  32. Importance of nucleation in transformation of octacalcium phosphate to hydroxyapatite Peer-reviewed

    Natsuko Ito, Masanobu Kamitakahara, Masahiro Yoshimura, Koji Ioku

    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS　40　121-126　2014/07

    DOI： 10.1016/j.msec.2014.03.034 　

    ISSN： 0928-4931

    eISSN： 1873-0191

  33. Preparation and evaluation of spherical porous granules of octacalcium phosphate/hydroxyapatite as drug carriers in bone cancer treatment Peer-reviewed

    Natsuko Ito, Masanobu Kamitakahara, Koji Ioku

    MATERIALS LETTERS　120　94-96　2014/04

    DOI： 10.1016/j.matlet.2014.01.040 　

    ISSN： 0167-577X

    eISSN： 1873-4979

  34. Promotion of Normal Healing of Bone Defects under Estrogen Deficiency by Implantation of Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles Peer-reviewed

    Eri Tatsukawa, Yoshinori Gonda, Masanobu Kamitakahara, Masaaki Matsuura, Masaru Ushijima, Yasuaki Shibata, Ikuho Yonezawa, Mutsunori Fujiwara, Koji Ioku, Tohru Ikeda

    JOURNAL OF ORTHOPAEDIC RESEARCH　32　(2)　189-196　2014/02

    DOI： 10.1002/jor.22514 　

    ISSN： 0736-0266

    eISSN： 1554-527X

  35. Formation of Stacked Disc-shaped Layered Double Hydroxides by Homogeneous Precipitation Method Peer-reviewed

    Taishi Yokoi, Masanobu Kamitakahara

    CHEMISTRY LETTERS　43　(2)　234-236　2014/02

    DOI： 10.1246/cl.130969 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  36. Behavior of osteoblast-like cells on calcium-deficient hydroxyapatite ceramics composed of particles with different shapes and sizes Peer-reviewed

    Masanobu Kamitakahara, Yuika Uno, Koji Ioku

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　25　(1)　239-245　2014/01

    DOI： 10.1007/s10856-013-5063-6 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  37. A bone substitute with high affinity for vitamin D-binding protein-relationship with niche of osteoclasts Peer-reviewed

    Tohru Ikeda, Michiyuki Kasai, Eri Tatsukawa, Masanobu Kamitakahara, Yasuaki Shibata, Taishi Yokoi, Takayuki K. Nemoto, Koji Ioku

    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE　18　(1)　170-180　2014/01

    DOI： 10.1111/jcmm.12180 　

    ISSN： 1582-4934

  38. Preparation and evaluation of spherical Ca-deficient hydroxyapatite granules with controlled surface microstructure as drug carriers Peer-reviewed

    Masanobu Kamitakahara, Ryohei Imai, Koji Ioku

    Materials Science and Engineering C　33　(4)　2446-2450　2013/05/01

    DOI： 10.1016/j.msec.2013.01.017 　

    ISSN： 0928-4931

  39. Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids Peer-reviewed

    Taishi Yokoi, Masanobu Kamitakahara, Masakazu Kawashita, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　121　(1410)　219-225　2013/02

    DOI： 10.2109/jcersj2.121.219 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  40. Characterization and In Vitro Evaluation of Silicate-Containing Tricalcium Phosphate Prepared through Wet Chemical Process Peer-reviewed

    Masanobu Kamitakahara, Shota Umemoto, Koji Ioku

    Key Engineering Materials　529-530　105-+　2013

    DOI： 10.4028/www.scientific.net/KEM.529-530.105 　

    ISSN： 1013-9826

  41. Observation of Transformation Behavior of Octacalcium Phosphate to Hydroxyapatite Peer-reviewed

    Natsuko Ito, Masanobu Kamitakahara, Koji Ioku

    Key Engineering Materials　529-530　11-+　2013

    DOI： 10.4028/www.scientific.net/KEM.529-530.11 　

    ISSN： 1013-9826

  42. Production of tubular porous hydroxyapatite using electrophoretic deposition Peer-reviewed

    Cem Bulent Ustundag, Figen Kaya, Masanobu Kamitakahara, Cengiz Kaya, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　120　(1408)　569-573　2012/12

    DOI： 10.2109/jcersj2.120.569 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  43. Synthesis of nanosized porous hydroxyapatite granules in hydrogel by electrophoresis Peer-reviewed

    Masanobu Kamitakahara, Kenshiro Kimura, Koji Ioku

    COLLOIDS AND SURFACES B-BIOINTERFACES　97　236-239　2012/09

    DOI： 10.1016/j.colsurfb.2012.03.033 　

    ISSN： 0927-7765

  44. COMPARISON OF ADSORPTION BEHAVIOR OF BOVINE SERUM ALBUMIN AND OSTEOPONTIN ON HYDROXYAPATITE AND ALUMINA Peer-reviewed

    Jumpei Hayashi, Masakazu Kawashita, Toshiki Miyazaki, Masanobu Kamitakahara, Koji Ioku, Hiroyasu Kanetaka

    Phosphorus Research Bulletin　26　23-28　2012/09

    Publisher: Japanese Association of Inorganic Phosphorus Chemistry

    DOI： 10.3363/prb.26.23 　

    ISSN： 0918-4783

    eISSN： 1882-2363

  45. TECHNIQUES FOR PREPARING PURE β-TRICALCIUM PHOSPHATE GRANULES COMPOSED OF ROD-SHAPED PARTICLES Peer-reviewed

    Masanobu Kamitakahara, Ryosuke Fujii, Koji Ioku

    Phosphorus Research Bulletin　26　29-32　2012/09

    DOI： 10.3363/prb.26.29 　

  46. PREPARATION OF SPHERICAL GRANULES OF OCTACALCIUM PHOSPHATE FOR MEDICAL APPLICATION Peer-reviewed

    Natsuko Ito, Masanobu Kamitakahara, Koji Ioku

    FUNCTIONAL MATERIALS LETTERS　5　(2)　1260009 (3 pages)　2012/06

    DOI： 10.1142/S1793604712600090 　

    ISSN： 1793-6047

    eISSN： 1793-7213

  47. Tubular hydroxyapatite formation through a hydrothermal process from alpha-tricalcium phosphate with anatase Peer-reviewed

    Masanobu Kamitakahara, Hiroko Takahashi, Koji Ioku

    JOURNAL OF MATERIALS SCIENCE　47　(9)　4194-4199　2012/05

    DOI： 10.1007/s10853-012-6274-9 　

    ISSN： 0022-2461

  48. Hydrothermal synthesis of porous hydroxyapatite ceramics composed of rod-shaped particles and evaluation of their fracture behavior Peer-reviewed

    Setsuaki Murakami, Katsuya Kato, Yuki Enari, Masanobu Kamitakahara, Noriaki Watanabe, Koji Ioku

    CERAMICS INTERNATIONAL　38　(2)　1649-1654　2012/03

    DOI： 10.1016/j.ceramint.2011.09.056 　

    ISSN： 0272-8842

  49. Synthesis and in vitro evaluation of hydroxyapatite with controlled morphology Peer-reviewed

    M. Kamitakahara, T. Saito, K. Ioku

    4TH INTERNATIONAL SYMPOSIUM ON FUNCTIONAL MATERIALS (ISFM2011)　339　012002-1-4　2012

    DOI： 10.1088/1742-6596/339/1/012002 　

    ISSN： 1742-6588

  50. Formation of octacalcium phosphates with co-incorporated succinate and suberate ions Peer-reviewed

    Taishi Yokoi, Hidetaka Kato, Ill Yong Kim, Koichi Kikuta, Masanobu Kamitakahara, Masakazu Kawashita, Chikara Ohtsuki

    DALTON TRANSACTIONS　41　(9)　2732-2737　2012

    DOI： 10.1039/c2dt11580h 　

    ISSN： 1477-9226

    eISSN： 1477-9234

  51. Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading Peer-reviewed

    Tohru Ikeda, Yoshinori Gonda, Eri Tatsukawa, Yasuaki Shibata, Masanobu Kamitakahara, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa, Koji Ioku

    ACTA HISTOCHEMICA ET CYTOCHEMICA　45　(5)　283-292　2012

    DOI： 10.1267/ahc.12012 　

    ISSN： 0044-5991

    eISSN： 1347-5800

  52. Characterisation and photocatalytic activity of structure-controlled spherical granules of an anatase/hydroxyapatite composite Peer-reviewed

    Masanobu Kamitakahara, Osamu Kawaguchi, Noriaki Watanabe, Koji Ioku

    MATERIALS RESEARCH BULLETIN　46　(12)　2283-2287　2011/12

    DOI： 10.1016/j.materresbull.2011.08.059 　

    ISSN： 0025-5408

  53. Morphology and Composition of Hydroxyapatite Particles Synthesized Hydrothermally from Tricalcium Phosphates Peer-reviewed

    Masanobu Kamitakahara, Yuki Enari, Noriaki Watanabe, Koji Ioku

    Trans. Mater. Res. Soc. Japan　36　(3)　405-408　2011/09

    Publisher: The Materials Research Society of Japan

    DOI： 10.14723/tmrsj.36.405 　

    ISSN： 1382-3469

    More details Close

    Hydroxyapatite (HA) ceramics are used as artificial bones and adsorbents. The properties of HA particles are dependent on their morphology and composition. To reveal the effects of these factors, tailored HA particles are required. In the present study, HA particles with a controlled morphology and composition were prepared using the hydrothermal treatment of α- or β-tricalcium phosphate (α- or β-TCP) particles in an acidic or basic solutions at 120−240 °C. Plate-like HA particles were obtained when α-TCP was treated with the acidic solution. Rod-like HA particles were obtained when α-TCP was treated with the basic solution or when β-TCP was treated with the acidic solution. Rice-like HA particles were obtained when β-TCP was treated with the basic solution. The HA particles that were obtained under these conditions had a calcium-deficient composition, and the Ca/P molar ratio approached the stoichiometric value when the treatment temperature was increased. The morphology and composition of HA particles were controlled by selecting the starting materials and hydrothermal conditions.

  54. Effect of preparative conditions on crystallinity of apatite particles obtained from simulated body fluids Peer-reviewed

    Mineo Hashizume, Yuka Nagasawa, Tomohiko Suzuki, Shin Kawashima, Masanobu Kamitakahara

    COLLOIDS AND SURFACES B-BIOINTERFACES　84　(2)　545-549　2011/06

    DOI： 10.1016/j.colsurfb.2011.02.014 　

    ISSN： 0927-7765

    eISSN： 1873-4367

  55. Behavior of beta-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia Peer-reviewed

    Teruhito Okumura, Yoshinori Gonda, Koji Ioku, Masanobu Kamitakahara, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa, Izumi Asahina, Tohru Ikeda

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　119　(1386)　101-104　2011/02

    DOI： 10.2109/jcersj2.119.101 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  56. Preparation of Granules of Calcium Deficient Hydroxyapatite Composed of Rod-Shaped Particles and Evaluation of their Potential for Drug Carrier Peer-reviewed

    Masanobu Kamitakahara, Kiyoko Sato, Ryosuke Fujii, Ryohei Imai, Koji Ioku

    JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY　47　(1)　28-31　2011

    ISSN： 0004-881X

  57. EFFECT OF SYNTHETIC CONDITIONS ON MORPHOLOGY AND COMPOSITION OF CARBONATE-CONTAINING HYDROXYAPATITE HYDROTHERMALLY SYNTHESIZED FROM CALCIUM CARBONATE Peer-reviewed

    Woonkyoung Park, Masanobu Kamitakahara, Takuya Nagamori, Koji Ioku

    Phosphorus Research Bulletin　25　72-77　2011

    Publisher: Japanese Association of Inorganic Phosphorus Chemistry

    DOI： 10.3363/prb.25.72 　

    ISSN： 0918-4783

    More details Close

    Carbonate-containing hydroxyapatite (CHA) particles were synthesized by the hydrothermal treatment of calcium carbonates with phosphate-containing solutions. The influence of synthesis conditions in the hydrothermal synthesis of CHA from calcium carbonate on the morphology and composition has been investigated. Morphological changes in CHA particles were observed depending on the crystal phase and size of starting materials and the pH of solutions. The character of the starting material and pH of the treatment solution were highly important factors to control the morphology and composition of the synthesized CHA.

  58. Preparation and biological evaluation of a fibroblast growth factor-2-apatite composite layer on polymeric material Peer-reviewed

    Kenkichi Sasaki, Ayako Oyane, Koji Hyodo, Atsuo Ito, Yu Sogo, Masanobu Kamitakahara, Koji Ioku

    BIOMEDICAL MATERIALS　5　(6)　065008　2010/12

    DOI： 10.1088/1748-6041/5/6/065008 　

    ISSN： 1748-6041

    eISSN： 1748-605X

  59. Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate Peer-reviewed

    Natsuko Ito, Masanobu Kamitakahara, Setsuaki Murakami, Noriaki Watanabe, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　118　(1380)　762-766　2010/08

    DOI： 10.2109/jcersj2.118.762 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  60. Formation of Hydroxyapatite Microtubes Assisted with Anatase under Hydrothermal Conditions Peer-reviewed

    Masanobu Kamitakahara, Setsuaki Murakami, Hiroko Takahashi, Noriaki Watanabe, Koji Ioku

    CHEMISTRY LETTERS　39　(8)　854-855　2010/08

    DOI： 10.1246/cl.2010.854 　

    ISSN： 0366-7022

    eISSN： 1348-0715

  61. Fabrication of porous blocks of calcium phosphate through hydrothermal processing under glycine coexistence Peer-reviewed

    Giichiro Kawachi, Hidetoshi Misumi, Hirotaka Fujimori, Seishi Goto, Chikara Ohtsuki, Masanobu Kamitakahara, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　118　(1379)　559-563　2010/07

    DOI： 10.2109/jcersj2.118.559 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  62. Formation of octacalcium phosphate with incorporated succinic acid through gel-mediated processing Peer-reviewed

    Taishi Yokoi, Hidetaka Kato, Masanobu Kamitakahara, Masakazu Kawashita, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　118　(1378)　491-497　2010/06

    DOI： 10.2109/jcersj2.118.491 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  63. Hydroxyapatite formation on porous ceramics of alpha-tricalcium phosphate in a simulated body fluid Peer-reviewed

    Tomohiro Uchino, Kohei Yamaguchi, Ichiro Suzuki, Masanobu Kamitakahara, Makoto Otsuka, Chikara Ohtsuki

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　21　(6)　1921-1926　2010/06

    DOI： 10.1007/s10856-010-4042-4 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  64. In vitro apatite formation on organic-inorganic hybrids in the CaO-SiO2-PO5/2-poly(tetramethylene oxide) system Peer-reviewed

    Mi-Young Koh, Masanobu Kamitakahara, Ill Yong Kim, Koichi Kikuta, Chikara Ohtsuki

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　21　(2)　385-392　2010/02

    DOI： 10.1007/s10856-009-3868-0 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  65. Calcium Deficient Hydroxyapatite for Medical Application Prepared by Hydrothermal Method Peer-reviewed

    Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda

    AIP Conf. Proc.　1251　304-+　2010

    DOI： 10.1063/1.3456339 　

    ISSN： 0094-243X

  66. ELECTROPHORETIC DEPOSITION FORMATION OF MACROPOROUS HYDROXYAPATITE CERAMIC TUBES Peer-reviewed

    Cem Bulent USTUNDAG, Cengiz KAYA, Koji IOKU, Masanobu KAMITAKAHARA

    Proceedings of Proceedings of 15th International Metallurgy & Materials Congress　589-596　2010

  67. CARBONATE HYDROXYAPATITE PREPARED BY HYDROTHERMAL TREATMENT OF CALCIUM CARBONATE Peer-reviewed

    Woonkyoung PARK, Zulhusmi bin MOHAMAD, Masanobu KAMITAKAHARA, Noriaki WATANABE, Cem Bulent USTUNDAG, Koji IOKU

    Proceedings of Proceedings of 15th International Metallurgy & Materials Congress　623-630　2010

  68. SYNTHESIS OF DESIGNED HYDROXYAPATITE PARTICLES USING HYDROTHERMAL PROCESS Peer-reviewed

    Masanobu KAMITAKAHARA, Natsuko ITO, Yuki ENARI, Noriaki WATANABE, Koji IOKU, Cem Bulent, USTUNDAG

    Proceedings of Proceedings of 15th International Metallurgy & Materials Congress　631-636　2010

  69. PREPARATION AND CHARACTERIZATION OF GRANULES COMPOSED OF ROD-SHAPED β-TRICALCIUM PHOSPHATE PARTICLES Peer-reviewed

    Ryosuke FUJII, Masanobu KAMITAKAHARA, Noriaki WATANABE, Tohru IKEDA, Koji IOKU

    Proceedings of Proceedings of 15th International Metallurgy & Materials Congress　637-643　2010

  70. PREPARATION OF HYDROXYAPATITE MICROTUBE USING HYDROTHERMAL PROCESS IN THE PRESENCE OF TITANIA Peer-reviewed

    Hiroko TAKAHASHI, Masanobu KAMITAKAHARA, Setsuaki MURAKAMI, Noriaki WATANABE, Koji IOKU

    Proceedings of Proceedings of 15th International Metallurgy & Materials Congress　637-643　2010

  71. Hydroxyapatite-forming capability and mechanical properties of organic-inorganic hybrids and alpha-tricalcium phosphate porous bodies Peer-reviewed

    Tomohiro Uchino, Masanobu Kamitakahara, Makoto Otsuka, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　118　(1373)　57-61　2010/01

    DOI： 10.2109/jcersj2.118.57 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  72. Effects of surface carboxylic acid groups of cerasomes, morphologically stable vesicles having a silica surface, on biomimetic deposition of hydroxyapatite in body fluid conditions Peer-reviewed

    Mineo Hashizume, Hiroyuki Horii, Jun-ichi Kikuchi, Masanobu Kamitakahara, Chikara Ohtsuki, Masao Tanihara

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　21　(1)　11-19　2010/01

    DOI： 10.1007/s10856-009-3829-7 　

    ISSN： 0957-4530

  73. Preparation of Globular Hydroxyapatite Composed of Platelike Particles Peer-reviewed

    K. Sasaki, M. Kamitakahara, N. Watanabe, K. Ioku

    Processing and Fabrication of Advanced Materials XVIII　3　1385-1392　2009/12

  74. The resorption with bone replacement of calcium-deficient hydroxyapatite with unique microstructure Invited Peer-reviewed

    K. Ioku, Masanobu Kamitakahara, Tohru Ikeda

    Processing and Fabrication of Advanced Materials XVIII　3　1113-1122　2009/12

  75. Effect of preparation conditions on the properties of bioactive glasses for testing SBF Peer-reviewed

    Masanobu Kamitakahara, Tasuku Yagi, Chikara Ohtsuki

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　20　(12)　2419-2426　2009/12

    DOI： 10.1007/s10856-009-3820-3 　

    ISSN： 0957-4530

    eISSN： 1573-4838

  76. Characterization of Hydroxyapatite Synthesized by Hydrothermal Treatment of Octacalcium Phosphate

    Natsuko Ito, Masanobu Kamitakahara, Setsuaki Murakami, Noriaki Watanabe, Koji Ioku

    Archives of BioCeramics Research Vol. 9　67-70　2009/12

  77. Effect of Ethanol Addition on Hydrothermal Synthesis of Hydroxyapatite

    Tomoyo Goto, Masanobu Kamitakahara, Koichi Kikuta, Chikara Ohtsuki

    Archives of BioCeramics Research Vol. 9　71-74　2009/12

  78. Hydrothermal Synthesis of Hydroxyapatite/Titania Granules Using Water-soluble Titanium Complex

    Masanobu Kamitakahara, Osamu Kawaguchi, Noriaki Watanabe, Koji Ioku

    Archives of BioCeramics Research Vol. 9　187-190　2009/12

  79. Preparation of Colloidal Apatite Particles under Body Fluid Conditions

    Mineo Hashizume, Yuka Nagasawa, Shin Kawashima, Tomohiko Suzuki, Masanobu Kamitakahara

    Archives of BioCeramics Research Vol. 9　223-226　2009/12

  80. Mechanical properties of porous hydroxyapatite ceramics composed of rod-shaped particles with controlled aspect ratio

    S. Murakami, K. Kato, Y. Enari, M. Kamitakahara, N. Watanabe, K. Ioku

    Archives of BioCeramics Research Vol. 9　263-266　2009/12

  81. Process of Organic Modification of Octacalcium Phosphates

    Hidetaka Kato, Taishi Yokoi, Masanobu Kamitakahara, Koichi Kikuta, Chikara Ohtsuki

    Archives of BioCeramics Research Vol. 9　371-374　2009/12

  82. Evaluation of photocatalytic activity of anatase/hydroxyapatite composite granules for environmental purification Peer-reviewed

    Masanobu Kamitakahara, Setsuaki Murakami, Noriaki Watanabe, Shidong Ji, Harumitsu Nishikawa, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1371)　1172-1174　2009/11

    DOI： 10.2109/jcersj2.117.1172 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  83. 過熱水蒸気によるスギの葉からの有機物質の抽出および抽出物の抗菌活性の評価 Peer-reviewed

    李 志霞, 林 宏飛, 山崎 仲道, 上高原 理暢, 井奥 洪二

    廃棄物資源循環学会論文誌　20　(6)　361-370　2009/11

    Publisher: Japan Society of Material Cycles and Waste Management

    DOI： 10.3985/jjsmcwm.20.361 　

    ISSN： 1883-5856

    More details Close

    For the development of effective utilization techniques for sugi (Cryptomeria Japonica) resources, as a novel reaction medium, superheated steam was used to extract organic substances from sugi leaves in a pressure range below saturated vapor pressure at 100~200°C. The yield with superheated steam at 170°C was about five times as high as that obtained at 100°C, and the yield also increased as extraction time and steam pressure increased. Steam with higher temperature and higher pressure contributed to enhancing the oil yield and extracting more high-molecular-weight compounds such as sesquiterpenes and diterpenes. In addition, to examine the effectiveness of the extracts obtained by superheated steam, their antimicrobial activities against 18 soil microorganisms were examined using the disk-diffusion method. Extracts obtained by superheated steam exhibited significant antimicrobial activity, especially against fungi and actinomycetes. The analysis of the chemical compositions of the extracts by GC-MS and GC-FID suggested that one or more of the monoterpenes and sesquiterpenes were the substances that were potentially responsible for such antimicrobial activity. Superheated steam exhibited some advantages in selectively extracting active antifungal ingredients from natural materials.

  84. Evaluation of Octacalcium Phosphate for Application to Drug Carrier Peer-reviewed

    N. Ito, M. Kamitakahara, N. Watanabe, K. Ioku

    Bioceramics 22　27-30　2009/10

  85. Synthesis of Silicon-doped Tricalcium Phosphate through Wet Chemical Process Peer-reviewed

    M. Kamitakahara, H. Kamura, N. Watanabe, K. Ioku, C. Ohtsuki

    Bioceramics 22　31-34　2009/10

  86. Preparation of Hydroxyapatite Spheres Composed of Plate-like Particles by Hydrothermal Treatment of Supersaturated Calcium Phosphate Solution Peer-reviewed

    K. Sasaki, M. Kamitakahara, N. Watanabe, K. Ioku

    Bioceramics 22　39-42　2009/10

  87. Surface Characterization of Hydroxyapatite with Specific Crystal Face Tailored by Hydrothermal Process Peer-reviewed

    Y. Enari, M. Kamitakahara, N. Watanabe, K. Ioku

    Bioceramics 22　55-58　2009/10

  88. Synthesis of Hydroxyapatite-Poly(vinyl alcohol) Composite through Hydrothermal Treatment of Dicalcium Phosphate Dihydrate Peer-reviewed

    T. Goto, M. Kamitakahara, G. Kawachi, K. Kikuta, C. Ohtsuki

    Bioceramics 22　595-598　2009/10

  89. Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts Peer-reviewed

    Yoshinori Gonda, Koji Ioku, Yasuaki Shibata, Takatoshi Okuda, Giichiro Kawachi, Masanobu Kamitakahara, Hisashi Murayama, Katsumi Hideshima, Shimeru Kamihira, Ikuho Yonezawa, Hisashi Kurosawa, Tohru Ikeda

    BIOMATERIALS　30　(26)　4390-4400　2009/09

    DOI： 10.1016/j.biomaterials.2009.05.002 　

    ISSN： 0142-9612

    eISSN： 1878-5905

  90. Protein adsorption on needle-shaped hydroxyapatite prepared by hydrothermal treatment of mixture composed of CaHPO4 center dot 2H(2)O and beta-Ca-3(PO4)(2) Peer-reviewed

    Giichiro Kawachi, Tomoko Watanabe, Shin-ichi Ogata, Masanobu Kamitakahara, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1367)　847-850　2009/07

    DOI： 10.2109/jcersj2.117.847 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  91. Formation of needle-like hydroxyapatite by hydrothermal treatment of CaHPO4 center dot 2H(2)O combined with beta-Ca-3(PO4)(2) Peer-reviewed

    Tomoko Watanabe, Giichiro Kawachi, Masanobu Kamitakahara, Koichi Kikuta, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1366)　759-764　2009/06

    DOI： 10.2109/jcersj2.117.759 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  92. Synthesis of Bioactive HEMA-MPS-CaCl2 Hybrid Gels: Effects of Catalysts in the Sol-Gel Processing on Mechanical Properties and in vitro Hydroxyapatite Formation in a Simulated Body Fluid Peer-reviewed

    Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki, Satoshi Hayakawa, Akiyoshi Osaka

    JOURNAL OF BIOMATERIALS APPLICATIONS　23　(6)　519-532　2009/05

    DOI： 10.1177/0885328208094262 　

    ISSN： 0885-3282

    eISSN： 1530-8022

  93. Fabrication of titania/hydroxyapatite composite granules for photo-catalyst Peer-reviewed

    Shidong Ji, Setsuaki Murakami, Masanobu Kamitakahara, Koji Ioku

    MATERIALS RESEARCH BULLETIN　44　(4)　768-774　2009/04

    DOI： 10.1016/j.materresbull.2008.09.047 　

    ISSN： 0025-5408

  94. Preparation and characterization of periodic porous frame of hydroxyapatite Peer-reviewed

    Liyun Zhou, Deping Wang, Wenhai Huang, Aihua Yao, Masanobu Kamitakahara, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1364)　521-524　2009/04

    DOI： 10.2109/jcersj2.117.521 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  95. Hydrothermal synthesis of hydroxyapatite from octacalcium phosphate: effect of hydrothermal temperature Peer-reviewed

    Masanobu Kamitakahara, Natsuko Ito, Setsuaki Murakami, Noriaki Watanabe, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　117　(1363)　385-387　2009/03

    DOI： 10.2109/jcersj2.117.385 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  96. HYDROTHERMAL TREATMENT OF ALPHA TRICALCIUM PHOSPHATE POROUS CERAMICS IN VARIOUS AQUEOUS SOLUTIONS Peer-reviewed

    Masanobu Kamitakahara, Koji Ioku, Giichiro Kawachi, Chikara Ohtsuki

    ADVANCES IN BIOCERAMICS AND POROUS CERAMICS　29　(7)　103-+　2009

    ISSN： 0196-6219

  97. FORMATION OF BONE-LIKE APATITE ON TRICALCIUM PHOSPHATE CERAMICS IN A SOLUTION MIMICKING BODY FLUID Peer-reviewed

    Chikara Ohtsuki, Kohei Yamaguchi, Tomohiro Uchino, Giichiro Kawachi, Koichi Kikuta, Masanobu Kamitakahara

    ADVANCES IN BIOCERAMICS AND POROUS CERAMICS　29　(7)　189-+　2009

    ISSN： 0196-6219

  98. Osteoconductivity of hydrothermally synthesized beta-tricalcium phosphate composed of rod-shaped particles under mechanical unloading Peer-reviewed

    Yoshinori Gonda, Koji loku, Takatoshi Okuda, Yasuaki Shibata, Masanobu Kamitakahara, Giichiro Kawachi, Ikuho Yonezawa, Hisashi Kurosawa, Tohru Ikeda

    BIOCERAMICS 21　396-398　253-256　2009

    DOI： 10.4028/0-87849-353-0.253 　

    ISSN： 1013-9826

  99. Calcium Phosphate Porous Materials with Unique Microstructures Peer-reviewed

    Koji Ioku, Masanobu Kamitakahara, Noriaki Watanabe, Osamu Kawaguchi, Setsuaki Murakami, Tohru Ikeda

    BIOCERAMICS 21　396-398　645-648　2009

    DOI： 10.4028/0-87849-353-0.645 　

    ISSN： 1013-9826

  100. Preparation of Calcium Phosphate Porous Materials with Unique Microstructures

    Koji Ioku, Masanobu Kamitakahara, Noriaki Watanabe, Toshiharu Takahashi, Setsuaki Murakami, Tohru Ikeda

    Archives of BioCeramics Research Vol. 8　28-31　2008/11

  101. Hydrothermal synthesis of magnetite/hydroxyapatite composite material for hyperthermia therapy for bone cancer Peer-reviewed

    Setsuaki Murakami, Toshiaki Hosono, Balachandran Jeyadevan, Masanobu Kamitakahara, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　116　(1357)　950-954　2008/09

    DOI： 10.2109/jcersj2.116.950 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  102. Synthesis of spherical granules composed of rod-shaped hydroxyapatite particles utilizing a hydrothermal process

    Masanobu Kamitakahara, Toshiharu Takahashi, Giichiro Kawachi, Noriaki Watanabe, Koji Ioku

    Proceedings of The 4th International Symposium on Apatites and Correlative Biomaterials (ISACB2008)　26-28　2008/09

  103. The slow resorption with replacement by bone of a hydrothermally synthesized pure calcium-deficient hydroxyapatite Peer-reviewed

    Takatoshi Okuda, Koji Ioku, Ikuho Yonezawa, Hideyuki Minagi, Yoshinori Gonda, Giichiro Kawachi, Masanobu Kamitakahara, Yasuaki Shibata, Hisashi Murayama, Hisashi Kurosawa, Tohru Ikeda

    BIOMATERIALS　29　(18)　2719-2728　2008/06

    DOI： 10.1016/j.biomaterials.2008.03.028 　

    ISSN： 0142-9612

  104. The biodegradability of poly(Pro-Hyp-Gly) synthetic polypeptide and the promotion of a dermal wound epithelialization using a poly(Pro-Hyp-Gly) sponge Peer-reviewed

    Masao Tanihara, Kazumi Kajiwara, Keiko Ida, Yoshihisa Suzuki, Masanobu Kamitakahara, Shin-ichi Ogata

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　85A　(1)　133-139　2008/04

    DOI： 10.1002/jbm.a.31496 　

    ISSN： 1549-3296

  105. Synthesis of octacalcium phosphate intercalated with dicarboxylate ions from calcium carbonate and phosphoric acid Peer-reviewed

    Masanobu Kamitakahara, Hiroaki Okano, Masao Tanihara, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　116　(1351)　481-485　2008/03

    DOI： 10.2109/jcersj2.116.481 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  106. Hydrothermal Synthesis of Hydroxyapatite Ceramics for Medical Application Peer-reviewed

    Koji Ioku, Masanobu Kamitakahara

    BIOMATERIALS IN ASIA: IN COMMEMORATION OF THE 1ST ASIAN BIOMATERIALS CONGRESS　317-326　2008

  107. Formation of FGF-2-apatite composite layer on ethylene-vinyl alcohol copolymer Peer-reviewed

    Kenkichi Sasaki, Ayako Oyane, Koji Hyodo, Atsuo Ito, Yu Sogo, Masanobu Kamitakahara, Koji Ioku

    BIOCERAMICS, VOL 20, PTS 1 AND 2　361-363　455-+　2008

    DOI： 10.4028/www.scientific.net/KEM.361-363.455 　

    ISSN： 1013-9826

  108. Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties Peer-reviewed

    Toshiharu Takahashai, Masanobu Kamitakahara, Giichiro Kawachi, Koji Ioku

    BIOCERAMICS, VOL 20, PTS 1 AND 2　361-363　83-+　2008

    ISSN： 1013-9826

  109. Synthesis of Si-containing tricalcium phosphate and its sintering behavior Peer-reviewed

    Masanobu Kamitakahara, Takashi Kurauchi, Masao Tanihara, Koji Ioku, Chikara Ohtsuki

    BIOCERAMICS, VOL 20, PTS 1 AND 2　361-363　59-+　2008

    ISSN： 1013-9826

  110. Microstructure designing of porous beta-tricalcium phosphate for control of reactions in the bone Peer-reviewed

    Koji Loku, Masanobu Kamitakahara, Giichiro Kawachi, Yoshinori Gonda, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa, Tohru Ikeda

    BIOCERAMICS, VOL 20, PTS 1 AND 2　361-363　989-+　2008

    ISSN： 1013-9826

  111. Preparation of bioactive spherical particles in the CaO-SiO2 system through sol-gel processing under coexistence of poly(ethylene glycol) Peer-reviewed

    Ill Yong Kim, Giichiro Kawachi, Koichi Kikutaa, Sung Baek Cho, Masanobu Kamitakahara, Chikara Ohtsuki

    JOURNAL OF THE EUROPEAN CERAMIC SOCIETY　28　(8)　1595-1602　2008

    DOI： 10.1016/j.jeurceramsoc.2007.11.006 　

    ISSN： 0955-2219

    eISSN： 1873-619X

  112. Synthesis of ceramics in MOn/2-SiO2 systems through sol-gel processing under coexistence of polyethylene glycol and in vitro evaluation of their bioactivity Peer-reviewed

    Ill-Yong Kim, Masanobu Kamitakahara, Giichiro Kawachi, Koichi Kikuta, Sung-Baek Cho, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　116　(1349)　56-62　2008/01

    DOI： 10.2109/jcersj2.116.56 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  113. Formation of hydroxyapatite on ceramics consisting of tricalcium phosphate in a simulated body fluid Peer-reviewed

    Tomohiro Uchino, Kohei Yamaguchi, Giichiro Kawachi, Koichi Kikuta, Masanobu Kamitakahara, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　116　(1349)　96-99　2008/01

    DOI： 10.2109/jcersj2.116.96 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  114. Preparation of bioactive microspheres of organic modified calcium silicates through sol-gel processing Peer-reviewed

    Ill Yong Kim, Chikara Ohtsuki, Giichiro Kawachi, Masanobu Kamitakahara, Sung-Baek Cho

    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY　45　(1)　43-49　2008/01

    DOI： 10.1007/s10971-007-1634-7 　

    ISSN： 0928-0707

    eISSN： 1573-4846

  115. Biomimetic deposition of hydroxyapatite on a synthetic polypeptide with beta sheet structure in a solution mimicking body fluid Peer-reviewed

    Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Toshiki Miyazaki, Masao Tanihara

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　19　(1)　387-393　2008/01

    DOI： 10.1007/s10856-007-3179-2 　

    ISSN： 0957-4530

  116. Preparation of hydroxyapatite porous ceramics with different porous structures using a hydrothermal treatment with different aqueous solutions Peer-reviewed

    Masanobu Kamitakahara, Chikara Ohtsuki, Giiehiro Kawachi, Deping Wang, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　116　(1349)　6-9　2008/01

    DOI： 10.2109/jcersj2.116.6 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  117. Preparation of magnetite nanoparticles coated with silica via a sol-gel approach Peer-reviewed

    Bing Liu, Deping Wang, Wenhai Huang, Aihua Yao, Masanobu Kamitakahara, Koji Ioku

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　115　(1348)　877-881　2007/12

    DOI： 10.2109/jcersj2.115.877 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  118. Synthesis of organic-inorganic hybrids of poly (Tetramethylene oxide)-calcium silicate and in vitro evaluation of their bioactivity Peer-reviewed

    Mi-Young Koh, Giichiro Kawachi, Koichi Kikuta, Masanobu Kamitakahara, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　115　(1347)　732-737　2007/11

    DOI： 10.2109/jcersj2.115.732 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  119. Preparation of hydroxyapatite porous ceramics by hydrothermal treatment of alpha tricalcium phosphate porous ceramics

    M. Kamitakahara, K. Ioku, G. Kawachi, C. Ohtsuki

    Archives of BioCeramics Research Volume 7　23-26　2007/09

  120. Formation of hydroxyapatite on ceramic body consisting of tricalcium phosphate in a simulated body fluid

    T. Uchino, K. Yamaguchi, G. Kawachi, K. Kikuta, M. Kamitakahara, C. Ohtsuki

    Archives of BioCeramics Research Volume 7　39-42　2007/09

  121. Control of particle size of CaO-SiO2 gel through a sol-gel processing under coexistence of polyethylene glycol

    I. Y. Kim, G. Kawachi, K. Kikuta, M. Kamitakahara, S. B. Cho, C. Ohtsuki

    Archives of BioCeramics Research Volume 7　59-62　2007/09

  122. Effect of microstructures of porous α-tricalcium phosphate ceramics on hydroxyapatite formation in a simulated body fluid

    K. Yamaguchi, G. Kawachi, T. Uchino, K. Kikuta, M. Kamitakahara, C. Ohtsuki

    Archives of BioCeramics Research Volume 7　67-70　2007/09

  123. Synthesis of calcium phosphates containing metal ions and evaluation of their catalytic activity for the decomposition of hydrogen peroxide Peer-reviewed

    Masanobu Kamitakahara, Akio Takahashi, Masao Tanihara, Giichiro Kawachi, Chikara Ohtsuki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　115　(1343)　425-428　2007/07

    DOI： 10.2109/jcersj.115.425 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  124. In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups Peer-reviewed

    Takahiro Kawai, Chikara Ohtsuki, Masanobu Kamitakahara, Kayo Hosoya, Masao Tanihara, Toshiki Miyazaki, Yoshimitsu Sakaguchi, Shigeji Konagaya

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　18　(6)　1037-1042　2007/06

    DOI： 10.1007/s10856-006-0081-2 　

    ISSN： 0957-4530

  125. Preparation of bioactive flexible poly(tetramethylene oxide) (PTMO)-CaO-Ta2O5 hybrids Peer-reviewed

    Masanobu Kamitakahara, Masakazu Kawashita, Noboru Miyata, Tadashi Kokubo, Takashi Nakamura

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　18　(6)　1117-1124　2007/06

    DOI： 10.1007/s10856-007-0147-9 　

    ISSN： 0957-4530

  126. Design of novel bioactive materials through organic modification of calcium silicate

    Ohtsuki Chikara, Miyazaki Toshiki, Kamitakahara Masanobu, Tanihara Masao

    Journal of the European Ceramic Society　27　(2)　1527-1533　2007/04/01

    Publisher: Elsevier

    DOI： 10.1016/j.msec.2011.05.015 　

    ISSN： 0928-4931

  127. Apatite-forming ability of micro-arc plasma oxidized layer of titanium in simulated body fluids Peer-reviewed

    Eungsun Byon, Yongsoo Jeong, Akari Takeuchi, Masanobu Kamitakahara, Chikara Ohtsuki

    SURFACE & COATINGS TECHNOLOGY　201　(9-11)　5651-5654　2007/02

    DOI： 10.1016/j.surfcoat.2006.07.051 　

    ISSN： 0257-8972

  128. Optical oxygen-sensing properties of porphyrin derivatives anchored on ordered porous aluminium oxide plates Peer-reviewed

    Naoko Araki, Yutaka Amao, Takuzo Funabiki, Masanobu Kamitakahara, Chikara Ohtsuki, Kazunori Mitsuo, Keisuke Asai, Makoto Obata, Shigenobu Yano

    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES　6　(7)　794-803　2007

    DOI： 10.1039/b618030b 　

    ISSN： 1474-905X

    eISSN： 1474-9092

  129. Control of calcium phosphate precipitation in hydrogel Peer-reviewed

    Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Chikara Ohtsuki

    BIOCERAMICS, VOL 19, PTS 1 AND 2　330-332　79-+　2007

    ISSN： 1013-9826

  130. Effects of polyethylene glycol on morphology of bioactive CaO-SiO2 gel Peer-reviewed

    I. Y. Kim, C. Ohtsuki, M. Kamitakahara, S. B. Cho

    BIOCERAMICS, VOL 19, PTS 1 AND 2　330-332　177-+　2007

    ISSN： 1013-9826

  131. Design of novel bioactive materials through organic modification of calcium silicate Peer-reviewed

    Chikara Ohtsuki, Toshiki Miyazaki, Masanobu Kamitakahara, Masao Tanihara

    JOURNAL OF THE EUROPEAN CERAMIC SOCIETY　27　(2-3)　1527-1533　2007

    DOI： 10.1016/j.jeurceramsoc.2006.04.018 　

    ISSN： 0955-2219

  132. Microstructure and Mechanical Properties of Organic-Inorganic Hybrids Prepared from Hema and MPS

    T. Uchino, C. Ohtsuki, K. Kikuta, M. Kamitakahara, M. Tanihara, S. Hayakawa, A. Osaka

    Proceedings of The 6th Asian BioCeramics Symposium　138-141　2006/11

  133. Preparation of Bioactive CaO-SiO2 Particles Modified with Silane Coupling Agents

    I. Y. Kim, C. Ohtsuki, K. Kikuta, M. Kamitakahara, S. B. Cho

    Proceedings of The 6th Asian BioCeramics Symposium　208-211　2006/11

  134. Effect of silane-coupling treatment on thermal decomposition of octacalcium phosphate Peer-reviewed

    Masanobu Kamitakahara, Chikara Ohtsuki, Akio Takahashi, Masao Tanihara

    Zairyo/Journal of the Society of Materials Science, Japan　55　(9)　881-884　2006/09

    DOI： 10.2472/jsms.55.881 　

    ISSN： 0514-5163

  135. Hydroxyapatite-forming ability and mechanical properties of organic-inorganic hybrids reinforced by calcium phosphates Peer-reviewed

    Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　114　(1332)　692-696　2006/08

    DOI： 10.2109/jcersj.114.692 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  136. Effect of ZnO addition on bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics containing apatite and wollastonite Peer-reviewed

    M Kamitakahara, C Ohtsuki, H Inada, M Tanihara, T Miyazaki

    ACTA BIOMATERIALIA　2　(4)　467-471　2006/07

    DOI： 10.1016/j.actbio.2006.03.001 　

    ISSN： 1742-7061

  137. Removal of formaldehyde by hydroxyapatite layer biomimetically deposited on polyamide film Peer-reviewed

    T Kawai, C Ohtsuki, M Kamitakahara, M Tanihara, T Miyazaki, Y Sakaguchi, S Konagaya

    ENVIRONMENTAL SCIENCE & TECHNOLOGY　40　(13)　4281-4285　2006/07

    DOI： 10.1021/es050098n 　

    ISSN： 0013-936X

  138. Apatite formation behavior on tricalcium phosphate (TCP) porous body in a simulated body fluid Peer-reviewed

    T Uchino, C Ohtsuki, M Kamitakahara, M Tanihara, T Miyazaki

    BIOCERAMICS 18, PTS 1 AND 2　309-311　251-254　2006

    ISSN： 1013-9826

  139. Fabrication of bioactive glass-ceramics by selective laser sintering Peer-reviewed

    RD Goodridge, C Ohtsuki, M Kamitakahara, DJ Wood, KW Dalgarno

    BIOCERAMICS 18, PTS 1 AND 2　309-311　289-292　2006

    ISSN： 1013-9826

  140. Effects of polyethylene glycol and methacryloxypropyltrimethoxysilane on morphology and bioactivity of CaO-SiO2 gel prepared by sol-gel method Peer-reviewed

    IY Kim, C Ohtsuki, M Kamitakahara, M Tanihara, SB Cho

    BIOCERAMICS 18, PTS 1 AND 2　309-311　317-320　2006

    ISSN： 1013-9826

  141. Apatite-forming ability of glass-ceramics containing whitlockite and diopside in a simulated body fluid Peer-reviewed

    M Kamitakahara, C Ohtsuki, Y Kozaka, M Tanihara, T Miyazaki

    BIOCERAMICS 18, PTS 1 AND 2　309-311　341-344　2006

    ISSN： 1013-9826

  142. Comparison of apatite formation on polyamide films containing carboxyl and sulfonic groups in a solution mimicking body fluid Peer-reviewed

    C Ohtsuki, T Kawai, M Kamitakahara, M Tanihara, T Miyazaki, Y Sakaguchi, S Konagaya

    BIOCERAMICS 18, PTS 1 AND 2　309-311　477-480　2006

    ISSN： 1013-9826

  143. Apatite formation on synthetic polypeptide with beta sheet structure in a solution mimicking body environment Peer-reviewed

    A Takeuchi, C Ohtsuki, M Kamitakahara, S Ogata, M Tanihara, T Miyazaki

    BIOCERAMICS 18, PTS 1 AND 2　309-311　489-492　2006

    ISSN： 1013-9826

  144. Development of novel bioactive PMMA-based bone cement and its in vitro and in vivo evaluation Peer-reviewed

    SB Cho, A Takeuchi, IY Kim, SB Kim, C Ohtsuki, M Kamitakahara

    BIOCERAMICS 18, PTS 1 AND 2　309-311　801-804　2006

    ISSN： 1013-9826

  145. Preparation of porous glass-ceramics containing whitlockite and diopside for bone repair Peer-reviewed

    M Kamitakahara, C Ohtsuki, Y Kozaka, S Ogata, M Tanihara, T Miyazaki

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　114　(1325)　82-86　2006/01

    DOI： 10.2109/jcersj.114.82 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  146. Thermosensitive gel formation of novel polypeptides containing a collagen-derived pro-hyp-gly sequence and an elastin-derived val-pro-uy-val-gly sequence Peer-reviewed

    Y Morihara, S Ogata, M Kamitakahara, C Ohtsuki, M Tanihara

    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY　43　(23)　6048-6056　2005/12

    DOI： 10.1002/pola.21097 　

    ISSN： 0887-624X

  147. Synthesis of poly(Pro-Hyp-Gly)(n) by direct polycondensation of (Pro-Hyp-Gly)(n), where n = 1, 5, and 10, and stability of the triple-helical structure Peer-reviewed

    T Kishimoto, Y Morihara, M Osanai, S Ogata, M Kamitakahara, C Ohtsuki, M Tanihara

    BIOPOLYMERS　79　(3)　163-172　2005/10

    DOI： 10.1002/bip.20348 　

    ISSN： 0006-3525

  148. Heterogeneous nucleation of hydroxyapatite on protein: structural effect of silk sericin Peer-reviewed

    A Takeuchi, C Ohtsuki, T Miyazaki, M Kamitakahara, S Ogata, M Yamazaki, Y Furutani, H Kinoshita, M Tanihara

    JOURNAL OF THE ROYAL SOCIETY INTERFACE　2　(4)　373-378　2005/09

    DOI： 10.1098/rsif.2005.0052 　

    ISSN： 1742-5689

  149. A comparative study of apatite deposition on polyamide films containing different functional groups under a biomimetic condition Peer-reviewed

    T Kawai, C Ohtsuki, M Kamitakahara, M Tanihara, T Miyazaki, Y Sakaguchi, S Konagaya

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　113　(1321)　588-592　2005/09

    DOI： 10.2109/jcersj.113.588 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  150. A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material Peer-reviewed

    Y Ito, H Hasuda, M Kamitakahara, C Ohtsuki, M Tanihara, IK Kang, OH Kwon

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING　100　(1)　43-49　2005/07

    DOI： 10.1263/jbb.100.43 　

    ISSN： 1389-1723

  151. Mesoporous calcium phosphate via post-treatment of alpha-TCP Peer-reviewed

    M Kitamura, C Ohtsuki, S Ogata, M Kamitakahara, M Tanihara, T Miyazaki

    JOURNAL OF THE AMERICAN CERAMIC SOCIETY　88　(4)　822-826　2005/04

    DOI： 10.1111/j.1551-2916.2005.00164.x 　

    ISSN： 0002-7820

  152. In vitro aging test for bioactive PMMA-based bone cement using simulated body fluid Peer-reviewed

    SB Cho, SB Kim, KJ Cho, IY Kim, C Ohtsuki, M Kamitakahara

    BIOCERAMICS, VOL 17　284-286　153-156　2005

    ISSN： 1013-9826

  153. Preparation of porous biphasic tricalcium phosphate and its in vivo behavior Peer-reviewed

    M Kamitakahara, C Ohtsuki, M Oishi, S Ogata, T Miyazaki, M Tanihara

    BIOCERAMICS, VOL 17　284-286　281-284　2005

    ISSN： 1013-9826

  154. Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin Peer-reviewed

    A Takeuchi, C Ohtsuki, M Kamitakahara, S Ogata, M Tanihara, T Miyazaki, M Yamazaki, Y Furutani, H Kinoshita

    BIOCERAMICS, VOL 17　284-286　329-332　2005

    ISSN： 1013-9826

  155. Apatite deposition on polyamide film containing silanol groups in simulated body environment Peer-reviewed

    T Kawai, C Ohtsuki, M Kamitakahara, M Tanihara, T Miyazaki, Y Sakaguchi, S Konagaya

    BIOCERAMICS, VOL 17　284-286　505-508　2005

    ISSN： 1013-9826

  156. Synthesis of biodegradable hybrid consisting of hydroxyapatite and alginate Peer-reviewed

    C Ohtsuki, K Hosoya, T Kawai, M Kamitakahara, S Ogata, T Miyazaki, M Tanihara

    BIOCERAMICS, VOL 17　284-286　779-782　2005

    ISSN： 1013-9826

  157. Effect of addition of tetraethoxysilane to bioactive hybrids consisting of 2-hydroxyethylmethacrylate and 3-methacryloxypropyltrimethoxysilane

    Masanobu Kamitakahara, Chikara Ohtsuki, Tomohiro Uchino, Masao Tanihara, Toshiki Miyazaki

    Abstracts of 13th International Workshop on Sol-Gel Science and Technology　307-308　2005

  158. Apatite-forming ability and mechanical properties of organic-inorganic hybrids reinforced by calcium phosphates

    Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki

    Abstracts of 13th International Workshop on Sol-Gel Science and Technology　603-604　2005

  159. Development of bioactive glass-ceramics for use with the selective laser sintering (SLS) process

    R. G. Goodridge, C. Ohtsuki, M. Kamitakahara, K. W. Dalgarno, D. J. Wood

    Archives of BioCeramics Research　5　43-46　2005

  160. Reinforcement of α-TCP porous body with organic-inorganic hybrids

    T. Uchino, C. Ohtsuki, M. Kamitakahara, M. Tanihara, T. Miyazaki

    Archives of BioCeramics Research　5　130-133　2005

  161. Hydroxyapatite deposition on Collagen-like Polypeptide Modified with Silanol Groups

    M. Kamitakahara, C. Ohtsuki, Y. Morihara, S. Ogata, M. Tanihara

    Archives of BioCeramics Research　5　210-213　2005

  162. Porous Calcium Pohspahte with Biomodal Pre Distribution by Chemical Treatment of Macroprous α-TCP

    C. Ohtsuki, M. Kitamura, S. Ogata, M. Kamitakahara, M. Tanihara, T. Miyazaki

    Archives of BioCeramics Research　5　328-331　2005

  163. Control of the microstructure of porous tricalcium phosphate: Effects of addition of Mg, Zn and Fe Peer-reviewed

    Masanobu Kamitakahara, Chikara Ohtsuki, Makoto Oishi, Shin-Ichi Ogata, Masao Tanihara, Toshiki Miyazaki

    Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　52　(5)　356-359　2005

    Publisher: Journal of the Japan Society of Powder and Powder Metallurgy

    DOI： 10.2497/jjspm.52.356 　

    ISSN： 0532-8799

  164. A novel covalently crosslinked gel of alginate and silane with the ability to form bone-like apatite Peer-reviewed

    K Hosoya, C Ohtsuki, T Kawai, M Kamitakahara, S Ogata, T Miyazaki, M Tanihara

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A　71A　(4)　596-601　2004/12

    DOI： 10.1002/jbm.a.30189 　

    ISSN： 0021-9304

  165. Precipitation of anatase in silicone and bioactivity of the products Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　112　(1311)　594-598　2004/11

    DOI： 10.2109/jcersj.112.594 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  166. Fabrication and chemical durability of porous bodies consisting of biphasic tricalcium phosphates Peer-reviewed

    Makoto Oishi, Chikara Ohtsuki, Makoto Kitamura, Masanobu Kamitakahara, Shin-ichi Ogata, Toshiki Miyazaki, Masao Tanihara

    Phosphorus Research Bulletin　17　95-100　2004/10

  167. Design of a novel bioactive calcium phosphate paste containing acetyl cellulose Peer-reviewed

    Takahiro Kawai, Chikara Ohtsuki, Hirofumi Inada, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki

    Phosphorus Research Bulletin　17　203-208　2004/10

  168. Coating of an apatite layer on polyamide films containing sulfonic groups by a biomimetic process Peer-reviewed

    T Kawai, C Ohtsuki, M Kamitakahara, T Miyazaki, M Tanihara, Y Sakaguchi, S Konagaya

    BIOMATERIALS　25　(19)　4529-4534　2004/08

    DOI： 10.1016/j.biomaterials.2003.11.039 　

    ISSN： 0142-9612

  169. Bioactivity of MgO-CaO-SiO2 Porous Glass-Ceramics Peer-reviewed

    Chikara Ohtsuki, Toshiki Miyazaki, Kikuka Kishiro, Masanobu Kamitakahara, Masao Tanihara

    J. Ceram. Soc. Japan, Suppl.　112　(5)　S809-S812　2004/05

    DOI： 10.14852/jcersjsuppl.112.0.S809.0 　

  170. Formation of Octacalcium Phosphate from an α-TCP Porous Body Peer-reviewed

    Makoto Kitamura, Chikara Ohtsuki, Shin-ichi Ogata, Masanobu Kamitakahara, Masao Tanihara

    J. Ceram. Soc. Japan, Suppl.　112　(5)　S817-S821　2004/05

    DOI： 10.14852/jcersjsuppl.112.0.S817.0 　

  171. Microstructure and bioresorbable properties of alpha-TCP ceramic porous body fabricated by direct casting method Peer-reviewed

    M Kitamura, C Ohtsuki, S Ogata, M Kamitakahara, M Tanihara

    MATERIALS TRANSACTIONS　45　(4)　983-988　2004/04

    DOI： 10.2320/matertrans.45.983 　

    ISSN： 1345-9678

    eISSN： 1347-5320

  172. Degradation of bioactive polydimethylsiloxane-CaO-SiO2-TiO2 and poly (tetramethylene oxide)-CaO-TiO2 hybrids in a simulated body fluid Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF THE AMERICAN CERAMIC SOCIETY　87　(2)　235-239　2004/02

    DOI： 10.1111/j.1551-2916.2004.00235.x 　

    ISSN： 0002-7820

  173. Precipitation of anatase in silicone and bioactivity of the products Peer-reviewed

    Masanobu Kamitakahara, Masakazu Kawashita, Noboru Miyata, Tadashi Kokubo, Takashi Nakamura

    Journal of the Ceramic Society of Japan　112　(1311)　594-598　2004

    Publisher: Ceramic Society of Japan

    DOI： 10.2109/jcersj.112.594 　

    ISSN： 0914-5400

  174. Fabrication of bioactive glass-ceramics containing zinc oxide Peer-reviewed

    C Ohtsuki, H Inada, M Kamitakahara, M Tanihara, T Miyazaki

    BIOCERAMICS, VOL 16　254-2　59-62　2004

    ISSN： 1013-9826

  175. Apatite deposition on silk sericin in a solution mimicking extracellular fluid: Effects of fabrication process of sericin film Peer-reviewed

    A Takeuchi, C Ohtsuki, M Kamitakahara, SI Ogata, M Tanihara, T Miyazaki, M Yamazaki, Y Furutani, H Kinoshita

    BIOCERAMICS, VOL 16　254-2　403-406　2004

    ISSN： 1013-9826

  176. Apatite-forming ability and mechanical properties of poly(tetramethylene oxide) (PTMO)-Ta2O5 hybrids Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, HM Kim, T Kokubo, C Ohtsuki, T Nakamura

    BIOCERAMICS, VOL 16　254-2　521-524　2004

    ISSN： 1013-9826

  177. Effect of sulfonic group and calcium content on apatite-forming ability of polyamide films in a solution mimicking body fluid Peer-reviewed

    T Kawai, C Ohtsuki, M Kamitakahara, T Miyazaki, M Tanihara, Y Sakaguchi, S Konagaya

    BIOCERAMICS, VOL 16　254-2　525-528　2004

    ISSN： 1013-9826

  178. Fabrication of alpha-tricalcium phosphate porous body having a uniform pore size distribution Peer-reviewed

    M Kitamura, C Ohtsuki, S Ogata, M Kamitakahara, M Tanihara

    BIOCERAMICS, VOL 16　254-2　965-968　2004

    ISSN： 1013-9826

  179. Control of Bioresorption of Porous alpha-Tricalcium Phosphate Peer-reviewed

    Toshiki Miyazaki, Chikara Ohtsuki, Akari Takeuchi, Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Hiromi Tanaka, Yoshiaki Furutani, Hisao Kinoshita

    Transactions of the Materials Research Society of Japan　29　(6)　2923-2926　2004

  180. Development of Bioactive Paste with Improved Handling Peer-reviewed

    Chikara Ohtsuki, Toshiki Miyazaki, Hirofumi Inada, Masanobu Kamitakahara, Masao Tanihara

    Transactions of the Materials Research Society of Japan　29　(6)　3327-3330　2004

  181. In vitro transformation of porous biphasic tricalcium phosphate into octacalcium phosphate and hydroxyapatite

    M. Oishi, C. Ohtsuki, M. Kamitakahara, S. Ogata, M. Tanihara, T. Miyazaki

    Proceedings of the Workshop on Biomechanical Engineering and Biomaterials, International Symposium on Bio-inspired Systems　24-27　2004

  182. Mechanical properties and apatite-forming ability of organic-inorganic hybrids prepared from 2-hydroxyethylmethacrylate and 3-methacryloxypropyltrimethoxysilane

    T. Uchino, C. Ohtsuki, M. Kamitakahara, M. Tanihara, T. Miyazaki

    Proceedings of the Workshop on Biomechanical Engineering and Biomaterials, International Symposium on Bio-inspired Systems　28-31　2004

  183. Apatite-Formation on Alginate Gels Modified with Silanol Groups: An Approach toward Alginate-Apatite Hybrids

    C. Ohtsuki, K. Hosoya, M. Kamitakahara, S. Ogata, M. Tanihara, T. Miyazaki

    Transactions of 7th World Biomaterials Congress　668-668　2004

  184. Fabrication of a Bioactive Calcium Phosphate Paste with Cellulose Acetate

    T. Kawai, C. Ohtsuki, T. Miyazaki, H. Inada, M. Kamitakahara, M. Tanihara

    Transactions of 7th World Biomaterials Congress　997-997　2004

  185. Compositional Dependence of Apatite Formation for PMMA-based Bone Cement

    S.B. Cho, S.B. Kim, K.J. Cho, C. Ohtsuki, M. Kamitakahara

    Transactions of 7th World Biomaterials Congress　1456-1456　2004

  186. Formation of Mesopores from Alpha-TCP Porous Bodies and their Characteristics of Protein Adsorption

    M. Kitamura, C. Ohtsuki, S. Ogata, M. Kamitakahara, M. Tanihara

    Transactions of 7th World Biomaterials Congress　1478-1478　2004

  187. Synthesis of Flexible Bioactive Materials by Modification of HEMA with Silanol Groups and Calcium Ions

    M. Kamitakahara, C. Ohtsuki, T. Uchino, M. Tanihara, T. Miyazaki

    Transactions of 7th World Biomaterials Congress　1767-1767　2004

  188. Setting behavior and mechanical properties of bioactive paste composed of calcium phosphates and acetyl cellulose

    Chikara Ohtsuki, Takahiro Kawai, Hirofumi Inada, Masanobu Kamitakahara, Toshiki Miyazaki, Masao Tanihara

    Archives of BioCeramics Research　4　39-42　2004

  189. Preparation of bioactive glass-ceramics containing tricalcium phosphate and diopside

    Masanobu Kamitakahara, Yuko Kozaka, Chikara Ohtsuki, Masao Tanihara

    Archives of BioCeramics Research　4　70-73　2004

  190. Reinforcement of α-tricalcium phosphate porous body with organic-inorganic hybrids consisting of 2-hydroxyethylmethacrylate and 3-methacryloxypropyltrimethoxysilane

    Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki

    Archives of BioCeramics Research　4　74-77　2004

  191. Effect of particle size and shape of inorganic filler on mechanical property of organic/inorganic composite

    S.B. Cho, S.B. Kim, I.Y. Kim, C. Ohtsuki, M. Kamitakahara

    Archives of BioCeramics Research　4　138-141　2004

  192. Preparation of Bioactive Glass-ceramics in ZnO-CaO-SiO2-P2O5-CaF2 System

    Masanobu Kamitakahara, Chikara Ohtsuki, Hirofumi Inada, Masao Tanihara, Toshiki Miyazaki

    XX International Congress on Glass Proceedings　2004

  193. Fabrication of Porous Bioactive Glass-ceramics in MgO-CaO-SiO2 System

    Chikara Ohtsuki, Masanobu Kamitakahara, Kikuka Kishiro, Masao Tanihara, Toshiki Miyazaki

    XX International Congress on Glass Proceedings　2004

  194. Composite of Biodegradable Nanofiber with Hydroxyapatite

    Yoshihiro Ito, Hirokazu Hasuda, Masanobu Kamitakahara, Chikara Ohtsuki, Masao Tanihara, Oh Hyeong Kwon, Inn-Kyu Kang

    Proceedings of 4th Asian International Symposium on Biomaterials (AISB4) and 2nd International Symposium on Fusion of Nano and Bio Technologies　180-180　2004

  195. Fabrication of α-tricalcium phosphate porous ceramics with controlled pore structure Peer-reviewed

    Makoto Kitamura, Chikara Ohtsuki, Shin-Ichi Ogata, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki

    Zairyo/Journal of the Society of Materials Science, Japan　53　(6)　594-598　2004

    Publisher: Society of Materials Science Japan

    DOI： 10.2472/jsms.53.594 　

    ISSN： 0514-5163

  196. Apatite formation on CaO-free polydimethylsiloxane (PDMS)-TiO2 hybrids Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　14　(12)　1067-1072　2003/12

    DOI： 10.1023/B:JMSM.0000004003.41223.36 　

    ISSN： 0957-4530

  197. Apatite-forming ability and mechanical properties of CaO-free poly(tetramethylene oxide) (PTMO)-TiO2 hybrids treated with hot water Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    BIOMATERIALS　24　(8)　1357-1363　2003/04

    DOI： 10.1016/S0142-9612(02)00513-6 　

    ISSN： 0142-9612

  198. Preparation of bioactive inorganic-organic hybrids by hot water treatment Peer-reviewed

    M Kawashita, M Kamitakahara, N Miyata, T Kokubo, T Nakamura

    27TH INTERNATIONAL COCOA BEACH CONFERENCE ON ADVANCED CERAMICS AND COMPOSITES: A　24　(3)　221-226　2003

    ISSN： 0196-6219

  199. Flexible poly(tetramethylene oxide) (PTMO)-TiO2 hybrid with apatite-forming ability Peer-reviewed

    M Kamitakahara, R Shineha, M Kawashita, N Miyata, T Kokubo, T Nakamura

    BIOCERAMICS 15　240-2　155-158　2003

    ISSN： 1013-9826

  200. Mechanical properties of bioactive PDMS-CaO-SiO2-TiO2 and PTMO-CaO-TiO2 hybrids soaked in a simulated body fluid Peer-reviewed

    N Miyata, M Kamitakahara, M Kawashita, T Kokubo, T Nakamura

    BIOCERAMICS 15　240-2　943-946　2003

    ISSN： 1013-9826

  201. Fabrication of porous ceramics consisting of biphasic tricalcium phosphate

    M. Oishi, C. Ohtsuki, M. Kamitakahara, T. Miyazaki, M. Tanihara

    Archives of BioCeramics Research　3　14-19　2003

  202. Effect of sericin coating on biodegradation of porous alpha-tricalcium phosphate

    A. Takeuchi, C. Ohtsuki, M. Kamitakahara, S. Ogata, M. Tanihara, T. Miyazaki, M. Yamazaki, Y. Furutani, H. Kinoshita

    Archives of BioCeramics Research　3　114-117　2003

  203. Preparation of Three-dimensional Alginate-Apatite Nanohybrid

    K. Hosoya, C. Ohtsuki, M. Kamitakahara, S. Ogata, T. Miyazaki, M. Tanihara

    Archives of BioCeramics Research　3　226-230　2003

  204. Preparation and Characterization of Novel PMMA-Based Bone Cement

    S.B. Cho, S.B. Kim, K.J. Cho, C. Ohtsuki, M. Kamitakahara

    Archives of BioCeramics Research　3　342-345　2003

  205. Addition of Zinc Oxide to Bioactive Glass-Ceramics

    M. Kamitakahara, H. Inada, C. Ohtsuki, M. Tanihara, T. Miyazaki

    Archives of BioCeramics Research　3　360-363　2003

  206. Bioactivity and mechanical properties of polydimethylsiloxane (PDMS)-CaO-SiO2 hybrids with different calcium contents Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE　13　(11)　1015-1020　2002/11

    DOI： 10.1023/A:1020324101682 　

    ISSN： 0957-4530

  207. Apatite-forming ability and mechanical properties of polydilmethylsiloxane (PDMS)-TiO2 hybrid treated with hot water Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    BIOCERAMICS 14　218-2　633-636　2002

    ISSN： 1013-9826

  208. Bioactive soft materials precipitating nano anatase particles

    M. Kamitakahara, M. Kawashita, N. Miyata, T. Kokubo, T. Nakamura

    Proceedings of 2nd Asian BioCereamics symposium　39-42　2002

  209. Effect of polyacrylic acid on the apatite formation of a bioactive ceramic in a simulated body fluid: fundamental examination of the possibility of obtaining bioactive glass-ionomer cements for orthopaedic use Peer-reviewed

    M Kamitakahara, M Kawashita, T Kokubo, T Nakamura

    BIOMATERIALS　22　(23)　3191-3196　2001/12

    DOI： 10.1016/S0142-9612(01)00071-0 　

    ISSN： 0142-9612

  210. Bioactivity and mechanical properties of polydimethylsiloxane (PDMS)-CaO-SiO2 hybrids with different PDMS contents Invited Peer-reviewed

    M Kamitakahara, M Kawashita, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY　21　(1-2)　75-81　2001

    DOI： 10.1023/A:1011261617377 　

    ISSN： 0928-0707

  211. Preparation of Al-free glass-ionomer cement Peer-reviewed

    M Kamitakahara, HM Kim, F Miyaji, T Kokubo, T Nakamura

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　108　(12)　1117-1118　2000/12

    DOI： 10.2109/jcersj.108.1264_1117 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  212. Preparation of bioactive PDMS-modified CaO-SiO2-TiO2 hybrids by the sol-gel method Peer-reviewed

    Q Chen, M Kamitakahara, N Miyata, T Kokubo, T Nakamura

    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY　19　(1-3)　101-105　2000/12

    DOI： 10.1023/A:1008774524468 　

    ISSN： 0928-0707

  213. Effect of PDMS content on bioactivity and mechanical properties of PDMS-CaO-SiO2 hybrids

    M. Kamitakahara, M. Kawashita, N. Miyata, T. Kokubo, T. Nakamura

    Transactions of the Sixth World Biomaterials Congress　1　262-262　2000

  214. Possibility for obtaining bioactive glass-ionomer cements Peer-reviewed

    M Kamitakahara, M Kawashita, T Kokubo, T Nakamura

    BIOCERAMICS　192-1　701-704　2000

    ISSN： 1013-9826

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Misc. 35

  1. New insights into immobilized bacterial systems for removal of heavy metals from wastewater Peer-reviewed

    U. Jhariya, M.-F. Chien, M. Umetsu, M. Kamitakahara

    International Journal of Environmental Science and Technology　2025

    Publisher: Springer Science and Business Media LLC

    DOI： 10.1007/s13762-025-06369-6 　

    ISSN： 1735-1472

    eISSN： 1735-2630

    More details Close

    Abstract Industrial and anthropogenic activities release heavy metals (HMs) from natural resources, transforming them into toxic elements. HMs can be extremely toxic, even at very low concentrations; their bioaccumulative nature damages ecosystem endurance and human health. Bacterial bioremediation of HMs is an effective, sustainable, and reliable method owing to inherent and adaptive systems of bacteria that facilitate significant HMs removal via adsorption, ion exchange, and bioaccumulation. However, the use of free cells in wastewater treatment compromises bioremediation efficiency. Bacterial immobilization emerges as a promising visionary technique for treating HMs-contaminated wastewater. Therefore, the present review elucidates the potential of various bacterial remediation mechanisms and highlights current research outcomes in the field of metal ion bioremediation. Furthermore, this review explores the importance and potential applications of bacterial immobilization in the context of metal ion bioremediation. A comprehensive literature review was conducted to demonstrate the advantages of immobilized bacterial cells in HM-contaminated wastewater treatment. The groundbreaking relationship between bacterial HM removal mechanisms and immobilization methods has been conclusively established. Future research that integrates bacterial HM removal mechanisms and bacterial immobilization methods could play an instrumental role in the effective treatment strategies and efficient recovery of HMs from wastewater.

  2. リン酸カルシウムの微構造制御による新機能創発 Invited

    上高原 理暢

    バイオマテリアル－生体材料－　42　(4)　298-303　2024/10

  3. 骨再生のためのリン酸カルシウム球状顆粒からなるセメントの作製 Invited Peer-reviewed

    梅津 将喜, 上高原理暢

    セラミックス　58　588-591　2023/09

  4. リン酸カルシウム球状多孔質顆粒の作製とその医療応用 Invited Peer-reviewed

    上高原理暢, 梅津 将喜

    PHOSPHORUS LETTER　(106)　7-17　2023/02

  5. Development of artificial bone capable of drug loading using octacalcium phosphate Invited Peer-reviewed

    Masanobu Kamitakahara

    Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy　65　(4)　197-201　2018

    Publisher: Journal of the Japan Society of Powder and Powder Metallurgy

    DOI： 10.2497/jjspm.65.197 　

    ISSN： 0532-8799

  6. 無機リン化学の基礎と応用 Invited Peer-reviewed

    井奥 洪二, 上高原理暢

    Phosphorus Letter　(88)　381-390　2017/06/01

    Publisher: 日本無機リン化学会)

    ISSN： 0917-9976

  7. Development of Composites Utilizing Bioceramics

    Phosphorus letter　(88)　410-420　2017

    Publisher: 日本無機リン化学会

    ISSN： 0917-9976

  8. バイオセラミックスとしてのリン酸カルシウム多孔体

    井奥洪二, 上高原 理暢

    Phosphorus Letter　(81)　17-26　2014/10

    Publisher: 日本無機リン化学会

    ISSN： 0917-9976

  9. バイオセラミックスを用いた複合材料の創成

    横井太史, 上高原理暢, 大槻主税

    Phosphorus Letter　(81)　58-68　2014/10

    Publisher: 日本無機リン化学会

    ISSN： 0917-9976

  10. 医療分野におけるバイオインスパイアード材料の応用

    井奥洪二, 横井太史, 上高原理暢

    セラミックス　49　(5)　397-401　2014/05

    Publisher: 日本セラミックス協会

    ISSN： 0009-031X

  11. 人工骨用リン酸カルシウム系材料の形態制御

    横井太史, 上高原理暢, 大槻主税

    機能材料　33　(9)　12-18　2013/09

    Publisher: シーエムシー出版

    ISSN： 0286-4835

  12. 骨代謝に組み込まれる水酸アパタイト多孔体

    井奥洪二, 上高原理暢, 池田通

    J. Soc. Inorg. Mater. Japan　19　(361)　396-400　2012

    Publisher: 無機マテリアル学会

    ISSN： 1345-3769

  13. Preparation of highly functional artificial bones using the properties of calcium phosphates

    Masanobu Kamitakahara

    JOURNAL OF THE CERAMIC SOCIETY OF JAPAN　119　(1388)　266-270　2011/04

    DOI： 10.2109/jcersj2.119.266 　

    ISSN： 1882-0743

    eISSN： 1348-6535

  14. Effects of ethanol addition on formation of hydroxyapatite through hydrothermal treatment of dicalcium phosphate dihydrate Peer-reviewed

    T. Goto, M. Kamitakahara, I. Y. Kim, C. Ohtsuki

    IOP Conference Series: Materials Science and Engineering　18　(13)　192014　2011

    DOI： 10.1088/1757-899X/18/19/192015 　

    ISSN： 1757-8981 1757-899X

  15. 骨代謝に組み込まれるリン酸カルシウムセラミックス

    井奥 洪二, 上高原 理暢, 米澤 郁穂

    Phosphorus letter　(65)　9-16　2009/06

    Publisher: 日本無機リン化学会

    ISSN： 0917-9976

  16. Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration

    Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki

    J. R. Soc. Interface　6　S349-S360　2009/06

    DOI： 10.1098/rsif.2008.0419.focus 　

  17. HYDROXYAPATITE CERAMICS FOR MEDICAL APPLICATION PREPARED BY HYDROTHEMAL METHOD

    Koji Ioku, Masanobu Kamitakahara

    Phosphorus Research Bulletin　23　25-30　2009/05

    DOI： 10.3363/prb.23.25 　

  18. 骨代謝に組み込まれるリン酸カルシウムセラミックス

    井奥 洪二, 上高原 理暢, 米澤 郁穂, 黒澤 尚, 池田 通

    Phosphorus Letter　(65)　8-15　2009

  19. Review Paper: Behavior of Ceramic Biomaterials Derived from Tricalcium Phosphate in Physiological Condition

    Masanobu Kamitakahara, Chikara Ohtsuki, Toshiki Miyazaki

    JOURNAL OF BIOMATERIALS APPLICATIONS　23　(3)　197-212　2008/11

    DOI： 10.1177/0885328208096798 　

    ISSN： 0885-3282

    eISSN： 1530-8022

  20. Ceramic Technology for Reducing Negative Impacts of Antibiotics on Environment

    伊藤敦夫, 大矢根綾子, 六崎裕高, 十河友, 上高原理暢, 井奥洪二

    セラミックス　43　(10)　2008/10

    ISSN： 0009-031X

  21. Coating of bone-like apatite for development of bioactive materials for bone reconstruction

    Masanobu Kamitakahara, Chikara Ohtsuki, Toshiki Miyazaki

    Biomedical Materials　2　(4)　R17-R23　2007/12/01

    DOI： 10.1088/1748-6041/2/4/R01 　

    ISSN： 1748-6041 1748-605X

  22. 生体活性セラミックスの生体内反応に基づく有機－無機ハイブリッドの創成

    上高原理暢, 宮崎敏樹

    マテリアルインテグレーション　20　(11)　73-77　2007/11

    Publisher: ティー・アイ・シィー

    ISSN： 1344-7858

  23. 生体適合性ハイブリッド材料

    谷原正夫, 上高原理暢

    高分子　56　(3)　144-149　2007/03

    Publisher: The Society of Polymer Science, Japan

    DOI： 10.1295/kobunshi.56.144 　

    ISSN： 0454-1138

  24. Coating bone-like apatite onto organic substrates using solutions mimicking body fluid

    Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki

    Journal of Tissue Engineering and Regenerative Medicine　1　(1)　33-38　2007/01

    DOI： 10.1002/term.3 　

  25. Apatite formation on CaO,SiO2-based glass ceramics

    Masanobu Kamitakahara, Chikara Ohtsuki

    Phosphorus Research Bulletin　20　101-110　2006/12

    DOI： 10.3363/prb.20.101 　

  26. セラミックスのニュープロセスとナノテクノロジー1.生体内での材料表面における反応を模倣する新しい合成プロセス

    大槻主税, 上高原理暢

    材料　55　(9)　885-890　2006/09

    Publisher: The Society of Materials Science, Japan

    DOI： 10.2472/jsms.55.885 　

    ISSN： 0514-5163

  27. α相とβ相が共存するリン酸三カルシウム多孔体の生体内における挙動のpQCT骨密度測定による評価

    上高原理暢, 大槻主税, 大石誠, 尾形信一, 谷原正夫, 宮崎敏樹

    Orthopaedic Ceramic Implants　23-24　81-84　2005

  28. リン酸三カルシウム多孔体の生体吸収性の制御

    大槻主税, 上高原理暢

    Phosphorus Letter　(53)　20-27　2005

    Publisher: 日本無機リン化学会

    ISSN： 0917-9976

  29. 骨組織の自己再生を支援するセラミックスの材料設計

    大槻主税, 上高原理暢, 宮崎敏樹

    セラミックス　40　862-864　2005

  30. 化学ベクトル制御による骨修復用ガラス材料の設計

    大槻主税, 上高原理暢, 宮崎敏樹

    マテリアルインテグレーション　18　(11)　7-11　2005

    Publisher: ティ-・アイ・シ-

    ISSN： 1344-7858

  31. Apatite Deposition on Polyamide Film Containing Silanol Groups in Simulated Body Environment

    T. Kawai, C. Ohtsuki, M. Kamitakahara, M. Tanihara, T. Miyazaki, Y. Sakaguchi, S. Konagaya

    Bioceramics 17　822-858　2004

  32. Bioactive inorganic-organic hybrids with deformability

    M Kawashita, M Kamitakahara, T Kokubo

    ANNALES DE CHIMIE-SCIENCE DES MATERIAUX　29　(1)　7-16　2004/01

    ISSN： 0151-9107

  33. Design of bioactive organic-inorganic hybrids on the basis of the bonding mechanism of calcium silicate glass with living bone

    C Ohtsuki, M Kamitakahara, T Miyazaki

    ANNALES DE CHIMIE-SCIENCE DES MATERIAUX　29　(1)　29-39　2004/01

    ISSN： 0151-9107

  34. 体液環境下における生体活性材料表面でのアパタイト析出

    大槻主税, 上高原理暢

    日本結晶成長学会誌　31　(2)　69-72　2004

    DOI： 10.19009/jjacg.31.2_69 　

  35. Control of hydroxyapatite deposition on organic polymer under biomimicking condition

    Chikara Ohtsuki, Takahiro Kawai, Masanobu Kamitakahara

    Phosphorus Research Bulletin　17　21-28　2004

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Books and Other Publications 10

  1. バイオマテリアル研究の最前線

    上高原理暢

    公益財団法人日本金属学会　2014/10

  2. セラミックス機能化ハンドブック

    大槻主税, 上高原理暢

    エヌ・ティー・エス　2011/01

  3. バイオマテリアルの基礎

    川下将一, 上高原理暢, 日本バイオマテリアル学会監修, 石原一彦, 塙隆夫, 前田瑞夫

    日本医学館　2010

  4. セラミックバイオマテリアル

    岡崎正之, 山下仁大, 尾坂明義, 石川邦夫, 大槻主税, 井奥洪二, 中村美穂, 上高原理暢

    コロナ社　2009

  5. Biomaterials in Asia

    Koji Ioku, Masanobu Kamitakahara

    World Scientific Publishing Co. Pte. Ltd.　2008/12

  6. Bio-inorganic Hybrid Nanomaterials

    Kamitakahara Masanobu, Toshiki Miyazaki, Chikara Ohtsuki

    WILEY-VCH Verlag GmbH & Co. KGaA　2008/02

  7. ゲノム情報による医療材料の設計と開発

    上高原理暢

    シーエムシー出版　2006/11

    More details Close

    第5章については，著者は，細谷佳代，上高原理暢である。

  8. 機能性ガラス・ナノガラスの最新技術

    上高原理暢, 大槻主税

    エヌ・ティー・エス　2006/07

  9. Ceramics and Composite Materials: New Research

    Kamitakahara Masanobu

    Nova Science Publishers　2006

  10. ゾルーゲル法のナノテクノロジーへの応用

    大槻主税, 上高原理暢, 宮崎敏樹

    シーエムシー出版　2005/11

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Presentations 17

  1. Potential of hydroxyxpatite as a scaffold material for microorganisms for water purification International-presentation

    4th Nagoya Biomimetics International Symposium　2015/10/30

  2. In vitro evaluation of calcium-deficient hydroxyapatite ceramics composed of rod-like particles International-presentation

    Takafumi Ebesu, Koji Ioku

    The 14th Asian BioCeramics Symposium (ABC2014)　2014/10/28

  3. Evaluation of Microorganism Adhesion on Hydroxyapatite as Scaffold for Microorganisms International-presentation

    Shohei Takahashi, Taishi Yokoi, Chihiro Inoue, Koji Ioku

    The 15th IUMRS-International Conference in Asia (IUMRS-ICA 2014)　2014/08/24

  4. 水酸アパタイト複合多孔体の水熱合成と評価

    村上節明, 上高原理暢, 井奥洪二

    日本セラミックス協会2007年年会　2007/03/21

  5. リン酸三カルシウムへのケイ素の導入

    倉内貴司, 上高原理暢, 谷原正夫, 大槻主税

    第45回セラミックス基礎科学討論会　2007/01/22

  6. ケイ素の添加がリン酸三カルシウムの相転移と緻密化に与える影響

    倉内貴司, 上高原理暢, 谷原正夫, 大槻主税

    第10回生体関連セラミックス討論会　2006/12/01

  7. Microstructure and Mechanical Properties of Organic-Inorganic Hybrids Prepared from Hema and MPS International-presentation

    T. Uchino, C. Ohtsuki, K. Kikuta, M. Kamitakhara, M. Tanihara, S. Hayakawa, A. Osaka

    6th Asian BioCeramics Symposium　2006/11/07

  8. Preparation of Bioactive CaO-SiO2 Particles Modified with Silane Coupling Agents International-presentation

    I. Y. Kim, C. Ohtsuki, K. Kikuta, M. Kamitakahara, S. B. Cho

    6th Asian BioCeramics Symposium　2006/11/07

  9. Control of Calcium Phosphate Precipitation in Hydrogel International-presentation

    Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Chikara Ohtsuki

    19th International Symposium on Ceramics in Medicine　2006/10/10

  10. Effects of Polyethylene Glycol on Morphology of Bioactive CaO-SiO2 Gel International-presentation

    I. Y. Kim, C. Ohtsuki, M. Kamitakahara, S.B.Cho

    19th International Symposium on Ceramics in Medicine　2006/10/10

  11. ジカルボン酸を層間に導入したリン酸八カルシウムの合成

    上高原理暢, 岡野浩明, 谷原正夫, 大槻主税

    日本セラミックス協会第19回秋季シンポジウム　2006/09/19

  12. 異なるプロセスで作製したα-TCPの水熱条件下における反応性

    川内義一郎, 大槻主税, 上高原理暢, 井奥洪二

    日本セラミックス協会第19回秋季シンポジウム　2006/09/19

  13. 体液類似水溶液中における天然および合成ポリペプチド表面での水酸アパタイト形成

    上高原理暢, 竹内あかり, 尾形信一, 谷原正夫, 宮崎敏樹, 大槻主税

    日本セラミックス協会第19回秋季シンポジウム　2006/09/19

  14. 体液類似環境を利用した水酸アパタイト-生体吸収性高分子複合体の創成

    上高原理暢, 尾形信一, 谷原正夫, 大槻主税

    日本セラミックス協会第1回関西支部学術講演会　2006/07/20

  15. 金属イオン含有リン酸カルシウムの合成とその過酸化水素の分解能

    上高原理暢, 高橋知央, 谷原正夫, 大槻主税

    日本材料学会第121回セラミック材料部門委員会　2006/07/19

  16. 電気泳動によるゲル中でのリン酸カルシウムの生成

    上高原理暢, 大槻主税, 尾形信一, 谷原正夫

    日本セラミックス協会2006年年会　2006/03/14

  17. xNa2#URO.xCaO.(100-x)SiO#D2(mol%)ガラスの結晶化挙動と擬似体液中でのアパタイト形成能

    八木扶, 大槻主税, 上高原理暢, 谷原正夫

    第29回京都窯業基礎科学懇談会　2006/03/09

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Research Projects 20

  1. 生体吸収性セラミックスに関する研究 Competitive

    2003/04 - Present

  2. 水酸アパタイトの環境浄化材料への応用に関する研究 Competitive

    2003/04 - Present

  3. 骨結合性を発現する有機-無機ハイブリッドに関する研究 Competitive

    1997/04 - Present

  4. 生物学的金属イオン回収のための外部刺激応答性担体の創製

    上高原 理暢, 梅津 将喜, 簡 梅芳

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的研究(萌芽)

    Institution: 東北大学

    2022/06/30 - 2025/03/31

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    微生物の付着・脱着の制御が可能な担体の創製に向けて、紫外線や超音波などによる外部刺激に応答する担体の創製に取り組んだ。純チタン金属を種々の条件で酸化処理することによりその表面に酸化チタン層を作製し、その表面上での微生物の挙動について調べ、陽極酸化を施すと酸化処理していない試料および大気酸化した試料よりも酵母が付着しやすいことを明らかにしている。今年度は、陽極酸化したチタン金属表面に酵母を付着させた後に紫外線を照射することで表面にラジカルを発生させて、酵母の付着に寄与する有機物を分解することで酵母の脱着を試みた。その結果、酵母の代謝活性が見られなくなったが、酵母はあまり脱着していない様子が観察された。有機分解能力が十分でなく脱着が起きなかった可能性を考え、陽極酸化したチタン金属表面の光触媒活性を高めることを考えた。陽極酸化したチタン金属を熱処理することで、紫外線を照射した際の有機物分解能を向上させることができた。しかし、その熱処理した陽極酸化チタン金属表面でも紫外線により酵母の脱着はあまり見られなかった。そこで、外部刺激として脱離に寄与する振動とラジカル生成を期待できる超音波照射を検討した。超音波照射すると、熱処理した陽極酸化チタン金属表面からの酵母の脱着が著しく促進されることが分かった。すなわち、超音波照射は酵母を脱着させるための有効な手段となることが分かった。今後、陽極酸化チタン金属表面での特異的な現象であるかどうかも検証していく予定である。一方で、酵母の付着と脱着には、酵母を付着させる際に用いる溶液の影響も大きいことが分かった。接着と脱着のメカニズム解明に重要な知見であると考えるため、溶液の影響についても今後検証していく予定である。

  5. ウィルスや環境負荷物質の高速高選択濃縮を可能とする高特性鉄ナノ粒子磁性ビーズ開発

    高橋 英志, 横山 俊, 横山 幸司, 上高原 理暢

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2021/04/01 - 2025/03/31

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    本研究では、生体材料向けに表面が清浄であり、無機被膜等により耐試薬性・耐腐食性を有し、抗体等付着と高分散性のために表面の特性制御(官能基や電位など)がなされた金属鉄ナノ粒子を開発する事で、ウィルスや環境負荷物質の高速高選択濃縮を可能とする高特性鉄ナノ粒子磁気ビーズ開発することを目的とする。 水溶液中において鉄錯体が難還元性の酸化物や水酸化物を形成せずに安定に存在しつつ還元剤で還元可能な条件を、錯生成定数を用いた計算予測とESI-TOF-MS等の機器分析を用いて予測する。表面の汚染は、反応場となる水溶液中の電位を水素ガス飽和条件と合成される鉄ナノ粒子の電気二重層／表面官能基制御により抑制する。表面官能基制御による均質被膜形成を通じて耐腐食性及び耐試薬性を付与し、その上で、目的とするウィルス等を選択的に付着可能な抗体や官能基を付与する。これらを総合的に行う事で、ウィルスや環境負荷物質の高速・高選択濃縮を可能とする高特性鉄ナノ粒子磁気ビーズを開発する。 研究期間内に4stepの研究開発を相互補完的に行い、目的を達成するために必須な要素を明らかにする事で、本研究の目的を達成する。2021年度はその第一段階を行った。液相中において合成したナノ粒子表面は、合成に使用する試薬の吸着若しくは官能基由来で進行する酸化などの腐食により汚染される。これらを原因とする汚染を抑制し清浄な表面を形成するために、(1)水素飽和等により、水反応場自体の電位を還元状態に制御するための技術を開発した、(2)合成される鉄ナノ粒子の反応場における電気二重層等表面電位制御技術開発等を行うことで、清浄表面を有する金属鉄ナノ粒子を合成する手法の基礎を開発した。

  6. 超多孔質リン酸Caセメントスペーサー再移植による新規Masquelet法の開発

    奥田 貴俊, 池田 通, 上高原 理暢

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(C)

    Institution: 順天堂大学

    2021/04/01 - 2024/03/31

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    Masquelet法においては、一期手術で挿入したセメント周囲に誘導される線維膜（induced membrane)が成功の鍵となる。我々は「induced membraneの生物学的な意義は、骨欠損部位に異物反応を起こさない骨髄線維組織を形成させ、骨外から異物反応を起こす線維組織が侵入することを防ぐ隔壁である」という仮説を立てた。本研究ではこの仮説を細胞生物学的に明らかにするとともに、一期手術で挿入する骨セメントスペーサーの代わりに、テフロン膜で覆った骨欠損部位に、材料工学研究者と共同で開発中の新規超多孔質リン酸カルシウムセメントスペーサーを移植し、骨髄線維組織および血管内皮細胞を豊富に含むスペーサーを形成させ、それを二期手術時に自家骨と混合して再移植することでMasquelet法の治療成績を上げ、かつ自家骨との混合移植における人工骨の比率をより高めることを目的とした。 先ずは我々が確立したF344ラット骨欠損モデルを用いて、テフロン膜で隔離した骨欠損部位に移植した超多孔質リン酸カルシウムセメントスペーサーを4週後に摘出し、異物反応を確認した。その結果、テフロン膜で隔離することでinduced membraneと同等の異物反応抑制効果があり、骨欠損部両端からスペーサー内に新生骨が出来てくることが分かった。 次に二期手術時に摘出後、自家骨と混合して再移植し、従来のMasquelet法との治癒過程の差を明らかにするため、1:1の混合比でモデルを作成し、現在経過観察中である。線維膜の形成が少ない場合には周囲をテフロン膜で覆う予定であったが、その必要性はないことが分かった。

  7. 骨再生を誘導する骨セメントの開発とその利用によるMasquelet法の革新的改良

    上高原 理暢, 池田 通, 奥田 貴俊

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 基盤研究(B)

    Institution: 東北大学

    2019/04/01 - 2023/03/31

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    本年度は、引き続きこれまでに創製したリン酸カルシウムセメントの評価を行うとともに、さらに新規なリン酸カルシウムセメントの創製にも取り組んだ。骨再生能力が高いと期待されているカルシウム欠損水酸アパタイト（CDHA）からなる球状多孔質顆粒に、水との反応により水酸アパタイトを形成して硬化するリン酸カルシウム粉末を結合材として水溶液と混合してペーストとし、これを硬化させることで、硬化体の気孔率は約80％と高く、気孔構造としては1マイクロメートル程度の微細な気孔（ミクロ孔）と100マイクロメートル程度の比較的な大きな気孔（マクロ孔）を有することを明らかにしてきた。このセメントの硬化体について、我々の提案する改良型Masquelet法に基づいて、動物実験を実施し、セメントの生物学的評価と改良型Masquelet法の評価を実施している。 一方で、CDHAからなる球状多孔質顆粒を用いたセメントでは、結合材として水酸アパタイトが顆粒表面を覆ってしまい、顆粒を構成するCDHAが表面に露出しないことが骨再生に不利になる可能性が考えられた。そこで、骨再生能力の高いリン酸八カルシウム（OCP）により顆粒同士を結合するセメントを創製した。α-リン酸三カルシウム（α-TCP）球状多孔質顆粒をリン酸水素カルシウム二水和物（DCPD）粉末と混合したセメントを創製した。水で練和することで、α-TCPとDCPDが反応してOCPの形成により硬化するセメントが得られた。硬化体は、ミクロ孔とマクロ孔を有した多孔構造を有し、しかも表面に骨再生能力の高いOCPが析出していた。顆粒内部にはα-TCPが残存したが、α-TCPも生体吸収性が高く骨再生能力があることも報告されていることから、骨再生能力の高いセメントが得られていると期待されるので、このセメントについても引き続き評価を続けていく予定である。

  8. Preparation of photoresponsive scaffolds that enable highly efficient biological recovery of rare metals

    Kamitakahara Masanobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Research (Exploratory)

    Institution: Tohoku University

    2019/06/28 - 2022/03/31

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    We prepared the titanium plates with titanium oxide layer on their surface by various oxidation treatments for the creation of the scaffolds that can control the attachment and detachment of microorganisms. By anodizing the titanium plate, it was possible to form a highly hydrophilic and rough titanium oxide layer. This anodized sample had higher adhesion to yeast than the unoxidized sample. When the yeast attached to the surface-oxidized titanium plate was irradiated with UV, the metabolic activity of the yeast decreased and the photocatalytic activity of titanium oxide was expressed. On the other hand, it was found that the yeast expressing the molybdenum-binding protein loaded on the porous ceramic could also recover molybdenum.

  9. Novel Finding of Masquelet technique in rat femoral critical sized bone model

    OKUDA TAKATOSHI

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (C)

    Institution: Juntendo University

    2018/04/01 - 2022/03/31

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    For a critical bone defect, as for two phases of bone reconstruction method (the Masquelet method) proposed by A.C.Masquelet, a good result is provided in clinical practice. However, there were few reports about the biological activity of the bone defect region of clinical practice, in spite of some basic researches about induced membrane. Therefore we evaluated bone defect region environment of the rat critical bone defect model. As a result, in the stroma of the bone defect region of the Masquelet method, the inflammatory granulation tissue and foreign body granuloma formation by the inflammation were controlled by induced membrane. Furthermore, promotion of the osteoclast induction by cytokine leads to bone metabolism activated. It was suggested that the environment of the bone defect region of the Masquelet method was advantageous to subsequently new bone formation.

  10. Synthesis of compound solar cell utilizing the printed electronics method

    Takahashi Hideyuki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2018/04/01 - 2021/03/31

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    To utilizing the solar energy, without the difference of the scale of countries and/or companies size, we should develop the effective synthesis method of compound solar cells in the liquid phase under the room temperature by using the simple equipment's only. Therefore, in this research, compound solar cell materials with well crystallized and homogenous condition were synthesized in water under room temperature and ambient pressure. The inks were formed by using these materials, and tried to make the cell plates by using these inks.

  11. Bone regeneration with bone substitute and cells in osteoclast lineage

    IKEDA Tohru, NISHIMURA Masahiro, KAMITAKAHARA Masanobu, IOKU Koji, ERI Tatsukawa

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    Institution: Nagasaki University

    2013/04/01 - 2016/03/31

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    We tried to show importance of osteoclasts for bone regeneration in the region implanted with bone substitutes and osteoblast progenitor cells. We implanted granules of biodegradable bone substitute, beta tricalcium phosphate (β-TCP) in rat subcutaneous tissue with or without bone marrow mesenchymal cells, which include osteoblast progenitor cells. Implantation of bone marrow mesenchymal cells induced not only osteogenesis, but also osteoclastogenesis. Osteoclastogenesis stimulated resorption of β-TCP. These results showed that implantation of bone marrow mesenchymal cells stimulated replacement of bone substitute to the bone. In addition, we found that hydroxyapatite composed of rod shaped particles induced osteoclast-like multinucleated giant cells without implantation of bone marrow mesenchymal cells. Furthermore, we showed divergence of multinucleated giant cells induced around hydroxyapatite granules implanted in the rat subcutaneous tissue.

  12. Studies for interaction between osteoblasts and osteoclasts with experimental systems using ceramics

    IKEDA Tohru, IOKU Koji, KAMITAKAHARA Masanobu, FUJITA Shuichi, SHIBATA Yasuaki, ISHIKAWA Yuichi, TATSUKAWA Eri

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nagasaki University

    2010/04/01 - 2014/03/31

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    We implanted granules of beta-tricalcium phosphate composed of rod-shaped particles in bone defects of ovariectomized rats. In the region, bone defects were regenerated with much amount of bone with physiological trabecular structures. Molecules involved in interferon signaling pathways were thought to induce the normal bone healing. We also found that hydroxyapatite composed of rod-shaped particles had strong interaction with vitamin D binding protein. Macrophage activating factor, an active form of vitamin D binding protein, possessed potent stimulatory effect for osteoclastogenesis and this molecule was thought to induce potent osteoconductivity of hydroxyapatite composed of rod-shaped particles.

  13. Preparation of bioresorbable bone-repairing materials which promote bone regeneration

    KAMITAKAHARA Masanobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Young Scientists (B)

    Institution: Tohoku University

    2011 - 2012

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    We aimed the preparation of bioresorbable bone-repairing materials which promote bone regeneration. We prepared silicate-containing tricalcium phosphate (TCP) and revealed that the sintered silicate-containing TCP showed higher apatite-forming ability in a simulated body fluid than the silicate-free TCP. When the compact of silicate-containingTCP powder was hydrothermally treated, the Ca-deficient HA ceramic composed of rod-shaped particles was obtained. On the other hand, we revealed that the dissolution rate of the Ca-deficient in the acidic buffer solution increased with the Ca-deficiency degree. We established the synthesis process and evaluated the basic materials.

  14. Challenge for creation of bioactivenanotubes

    IOKU Koji, KAMITAKAHARA Masanobu

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Challenging Exploratory Research

    2011 - 2012

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    Creation of bioactive hydroxyapatite（Ca_10(PO_4)_6(OH)_2）nanotubes was tried by two kinds of solution methods. First, the suspension of calcite（CaCO_3）with calcium hydroxide（Ca(OH)_2）and phosphoric acid solution were mixed under the controlled conditions

  15. Preparation of bioresorbable bone substitutes incorporated in bone metabolism

    IOKU Koji, IKEDA Tohru, KAMITAKAHARA Masanobu, WATANABE Noriaki

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Tohoku University

    2009 - 2011

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    A fabrication process of Ca-deficient HA with controlled composition and morphology of the particles which construct the HA ceramics was established by selecting the starting material and hydrothermal conditions. The possibility that the Ca-deficient composition and morphology of the particles affect the behavior of the HA ceramics in vivo was revealed. Moreover, it was revealed that the rod-shaped particles prevent the brittle fracture. From these results, we obtained the basic knowledge about the creation of bioresorbable bone substitute materials.

  16. 水酸アパタイトマイクロチューブの創製

    井奥 洪二, 上高原 理暢, 渡邉 則昭

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 挑戦的萌芽研究

    Institution: 東北大学

    2009 - 2010

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    水酸アパタイトの特徴を活かす材料として、チューブ状の水酸アパタイトを創製できれば、従来にないDrug Delivery System(DDS)や高効率の化学物質回収材料等として応用展開できる可能性がある。昨年度までに、アナターゼのナノ粒子をリン酸三カルシウム粉末と混合し、この混合粉末からなるペレットを水熱蒸気処理すると、柱状の水酸アパタイト粒子に混ざって、水酸アパタイトマイクロチューブが生成していることを発見した。本年度は、水酸アパタイトマイクロチューブの生成メカニズムの解明を目指し、まず添加するアナターゼの粒径や量の影響について調べた。その結果、ある特定の粒径でしかも特定の量のアナターゼを添加した場合にのみ、水酸アパタイトマイクロチューブが生成することを明らかにした。さらに、水酸アパタイトマイクロチューブが生成する系においてマイクロチューブ生成過程を詳細に調べたところ、まずリン酸三カルシウムと水が反応し、チューブ形状を取らない水酸アパタイトが生成し、その後結晶成長の段階でチューブ状になっていることが示唆された。すなわち、アナターゼが結晶成長に影響を与え、これにより水酸アパタイトマイクロチューブが生成している可能性を明らかにした。さらに、透過型電子顕微鏡観察により、生成した水酸アパタイトマイクロチューブは、c軸方向に成長し、a面と呼ばれる特定の結晶面を露出していることが示唆された。特定の結晶面の露出は、水酸アパタイトに吸着特性の選択性を付与する可能性がある。これらの成果は水酸アパタイトマイクロチューブの生成メカニズムの解明や大量生産につながるものと期待できる。

  17. 粒界制御による生体吸収性リン酸カルシウムセラミック人工骨の高機能化

    上高原 理暢

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 若手研究(B)

    2005 - 2006

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    骨組織の機能修復に用いる人工物のみで構築された人工骨は、提供者の倫理上の問題がなく安定した供給が可能で、保存も容易である。さらに、感染の心配もないので、移植や組織工学には無い利点を多く持つ。特に再生能力の旺盛な骨組織では、そのような体内での再構築を促進する人工材料の使用が望ましいと考えられる。リン酸三カルシウム(TCP, Ca_3(PO_4)_2)は、異物反応を起こさず、しかも生体内で骨再生に伴い吸収される材料として人工骨に使用されている。しかし、TCPには、焼結性に乏しく焼結に高温を要する、骨結合性が十分でない、生体内での吸収速度の調整が困難である、等の問題がある。そこで、粒界にシリケートが残存するようなTCPセラミックを設計すれば、その吸収速度を制御でき、しかも高い骨結合性を示すと期待される。昨年度、湿式法によるケイ素を含有するTCP粉末の合成手法を確立した。そこで、本年度は、その手法によって合成した粉末について、その焼結挙動を調べた。さらに、焼結して得られた緻密体の構造および擬似体液中での挙動について調べた。その結果、以下のことを明らかにした。 1.ケイ素を添加すると、焼結しやすくなり緻密体の相対密度が上がる。 2.ケイ素を含有するTCP緻密体において、ケイ素は粒子中よりも粒界部分に多く存在する。 3.擬似体液中においてケイ素を含有するTCP緻密体は、表面にアパタイト層を形成する。これは、高い骨結合性を示す可能性を示す。 4.ケイ素を添加すると、擬似体液中での緻密体の溶解速度が小さくなる。 これらの結果より、TCPにケイ素を添加することで、人工骨の高機能化を達成できる可能性が明らかとなった。

  18. 骨修復のための温度応答型リン酸カルシウム自己硬化性材料

    大槻 主税, 谷原 正夫, 尾形 信一, 上高原 理暢

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 奈良先端科学技術大学院大学

    2004 - 2005

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    従来のセラミックス系骨修復材料は、高い組織親和性や生体活性を示す反面、成形が困難で、手術室で成形し難い問題がある。近年、リン酸カルシウム粉末と水を反応させて硬化する骨修復用ペーストが実用化され、その有用性が認識されてきた。ただし、従来のリン酸カルシウムペーストには、手術の現場で、水と粉末を混ぜ合わせ均一な混合物を作る手間が必要であった。これに対して、温度応答性により硬化する材料が得られれば、手術室で煩雑な操作を必要としない画期的な自己硬化性骨修復材料になると期待される。本研究では、室温で流動性を示すペーストとして提供され、体温付近で自己硬化して、骨組織と結合する材料を創成するための基礎的指針を明らかにすることを目的とする。 昨年度、メチルセルロースと塩化ナトリウムを溶解した水溶液が、温度を上げるとゲル化することを明らかにした。この知見をもとに、この水溶液と骨の無機成分である水酸アパタイトの粉末を混合した。粉末の量が多くなるにつれて試料の粘度が大きくなる傾向が見られた。試料は、室温付近で流動性を示した。これを、50℃から100℃に保持すると、流動性がなくなり、硬化した。従って、水酸アパタイトなどのリン酸カルシウムと、メチルセルロースなどの温度応答性高分子水溶液を混合すれば、温度に応答して自己硬化して、骨組織と結合するペーストが得られると期待される。現段階では、体温付近でも試料の流動性は小さくなるもののその硬化は不十分であるので、今後硬化が体温付近でも十分に進行するような試料の作製条件を検討していく必要がある。

  19. 低侵襲治療のための体内硬化型有機―無機ナノハイブリッド骨修復材料

    大槻 主税, 上高原 理暢

    Offer Organization: 日本学術振興会

    System: 科学研究費助成事業

    Category: 萌芽研究

    Institution: 奈良先端科学技術大学院大学

    2002 - 2003

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    ヒトの運動機能を支持する骨組織の欠損は、生活の質(QOL)の大幅な低下をもたらす。従って、けがや病気で欠損が生じた場合には、短期でその機能を回復する医療技術が重要となる。現在、骨欠損部の機能を修復する場合に、金属やセラミックスでできたインプラント材料が使用されている。しかし、それらの埋入においては、インプラント材料に合わせて周囲の骨組織を成形する必要があり、患者への組織侵襲が大きくなってしまう。臨床の現場からは、手術室で自由に成形できる操作性、骨と直接結合する生物学的親和性(生体活性)ならびに骨と同等な力学的特性が求められている。これらの要求を満たす新素材の開発をするために、本研究課題では、流動性を示す状態で供給され、体液と接触すると有機高分子と水酸アパタイトを析出しながら硬化して、骨組織と結合できる有機-無機ハイブリッドとなる新素材を創成することを目的とする。 本年度は、酢酸セルロースを乳酸エチルに溶解させた溶液とリン酸四カルシウムとリン酸水素カルシウムの等モル混合物を練和したペーストの水溶液中における力学的特性および化学的特性を調べた。ペーストを緩衝液(pH7.25)に浸漬すると、ペーストは酢酸セルロースおよび水酸アパタイトを析出しながら硬化した。緩衝液に7日間浸漬した後の試料の圧縮強度および弾性率は、酢酸セルロース濃度または粉液比が大きくなるにつれ大きくなる傾向が見られ、ヒトの海綿骨と同等の値を示す硬化体も得られた。さらに、ペーストをヒトの体液とほぼ等しい無機イオン濃度を有する擬似体液に浸漬すると、硬化が進行すると共に試料表面にアパタイトを析出した。これは、得られたペーストが生体活性を示す可能性が高いことを示す。以上の結果より、得られたペーストは体液との反応で硬化し、ヒトの海綿骨と同等の力学的性質と生体活性を併せ示す新規骨修復材料として期待される。

  20. Control of bioactivity of organic-inorganic nanohybrids

    OHTSUKI Chikara, KAMITAKAHARA Masanobu, MIYAZAKI Toshiki, TANIHARA Masao

    Offer Organization: Japan Society for the Promotion of Science

    System: Grants-in-Aid for Scientific Research

    Category: Grant-in-Aid for Scientific Research (B)

    Institution: Nara Institute of Science and Technology

    2001 - 2003

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    A material which shows both bone-bonding ability, i.e. bioactivity, and mechanical properties similar to those of human bone is desired to be developed. In the present study, organic-inorganic hybrids were prepared through organic modification of Si-OH group and Ca^<2+>, and the factors that govern their microstructures, bioactivity and mechanical properties were fundamentally investigated, in order to fabricate a novel bone-repairing material. A type of organic-inorganic hybrids were prepared through modification of 2-hydroxyethylmethacrylate(HEMA), which gives hydrophilic polymer, with 3-methacryloxypropyltrimethoxysilane(MPS)and calcium chloride(CaCl_2), which give silanol groups and calcium ions, respectively. The bioactivity of the obtained hybrids was able to be controlled by the content of CaCl_2 or the addition of catalysts in the synthesis procedure. In this system, some of the obtained hybrids showed Young's modulus and strain at failure similar to those of human articular cartilage. On the basis of these findings, silanol groups and calcium ions were introduced to various organic polymers and their bioactivity was examined. It was found that we can induce bioactivity on the poly(methylmethacrylate) bone cement which is clinically used, if methylmethacrylate was modified with MPS and water-soluble calcium salts we revealed that bioactivity can be induce d on various organic polymers by modification with silanol groups and calcium ions, and the bioactivity and mechanical *erties of the resultant hybrids can be controlled by the kinds of polymer, the way of addition of calcium ions, synthesis conditions and so on.

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  1. 資源開発のための熱水性人工鉱床構築の可能性の探索

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    資源開発のための熱水性人工鉱床構築の可能性の探索を行う。

  2. リン酸八カルシウムの生体内反応を利用したドラッグデリバリーシステムの構築

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    リン酸八カルシウムの生体内反応を利用したドラッグデリバリーシステムの構築を行う。

  3. Synthesis of Silicon-doped Tricalcium Phosphate through Wet Chemical Process

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    ケイ素含有リン酸三カルシウムの湿式合成について研究する。

  4. イオンの電気泳動を利用したリン酸カルシウム粒子の作製

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    イオンの電気泳動を利用したリン酸カルシウム粒子の作製を行う。

  5. リン酸カルシウムが生命現象に与える影響の解明

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    リン酸カルシウムが生命現象に与える影響を解明する。

  6. 低環境負荷医療を目指した生体材料の開発に関する調査研究

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    低環境負荷医療を目指した生体材料の開発に関する調査研究を行う。

  7. Synthesis of Si-containing Tricalcium Phosphate and Its Sintering Behavior

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    ケイ素含有リン酸三カルシウムの合成と焼結挙動について調べる。

  8. 平成19年度 京都・先端ナノテクノロジー総合支援ネットワーク事業

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    高機能性リン酸カルシウム材料の開発における試料のナノスケール解析

  9. エレクトロニクスへの応用を目指したリン酸カルシウム微粒子の合成

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    本研究では、エレクトロニクスへの応用を目指し、形状および粒径を制御したリン酸カルシウム微粒子の新規合成法を開発する。

  10. 有機合成への利用を目指した基質選択性を持つチタニア光触媒の開発

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    有機合成への利用を目的とした光触媒の開発を行った。

  11. 骨修復を目指した新規リン酸カルシウムセラミックスの開発

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    リン酸三カルシウムとガラスを複合化することで、合成が容易で、しかも高い骨結合性と吸収性を併せ示す骨修復材料の開発を行う。

  12. 有機合成への利用を目指した基質選択性を持つチタニア光触媒の開発

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    有機合成への利用を目的とした光触媒の開発を行った。

  13. Apatite-forming ability and mechanical properties of poly(tetramethylene oxide)

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    国際会議に参加するための費用を援助していただいた。

  14. 化学合成コラーゲンとアパタイトナノ粒子のハイブリッドによる次世代人工骨の開発

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    化学合成コラーゲンとアパタイトナノ粒子を複合化することで、新規な人工骨を開発することを目的とする。

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